id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103350-jj9pc4a6	Tang, Pingtao	An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy	2020-05-08		.txt	text/plain	4041	204	46	rAd-Tat and LacZ control vectors (2 × 109) were expressed in the kidney of newborn wild type and HIV-transgenic (Tg26) FVB/N mice without significant proteinuria (n = 5 8 per group). Results HIV-Tat induced the expression of HIV-1 genes (env) and heparin binding growth factors in the kidney of HIV-Tg26 mice, and precipitated HIVAN in the first month of life. Summary statement We developed a new inducible mouse model system of childhood HIV-associated nephropathy, and demonstrated that HIV-Tat plays a critical role in this renal disease acting in synergy with other HIV-1 genes and heparin binding cytokines. Therefore, we carried out this study to determine whether the HIV-1 trans-activator (Tat) gene precipitates HIVAN in young mice, and define whether this approach could be used to generate an inducible mouse model system of childhood HIVAN. Our study showed that the activation and basic binding domains of Tat are sufficient to induce the renal expression of HIV-genes and precipitate HIVAN in young mice.	./cache/cord-103350-jj9pc4a6.txt	./txt/cord-103350-jj9pc4a6.txt