id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-029416-738t6rk1	Mandal, Sandip	The potential impact of preventive therapy against tuberculosis in the WHO South-East Asian Region: a modelling approach	2020-07-20		.txt	text/plain	5177	255	43	The 2018 World Health Organization (WHO) guidelines on eligibility for preventive therapy to treat latent TB infection (LTBI) include people living with human immunodeficiency virus (PLHIV), household contacts of TB patients including children, and those with clinical conditions including silicosis, dialysis, transplantation, etc. Relative to both scenarios, for each country in the region, we projected TB cases and deaths averted between 2020 and 2030, by full uptake of preventive therapy, defined as comprehensive coverage amongst eligible populations as per WHO guidelines, and assuming outcomes consistent with clinical trials. In the absence of a widely deployable test to identify who would benefit most from preventive therapy, World Health Organization (WHO) guidelines identify high-risk groups for eligibility: for example, those with human immunodeficiency virus (HIV) coinfection [10] and, in the most recently updated guidelines, all household contacts of diagnosed TB cases and those with clinical conditions including silicosis, those on anti-TNF treatment, and other country-specific groups [11] .	./cache/cord-029416-738t6rk1.txt	./txt/cord-029416-738t6rk1.txt