id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017439-0c6ohmmg	Hughes-Oliver, Jacqueline M.	Pooling Experiments for Blood Screening and Drug Discovery	2006		.txt	text/plain	7874	461	51	Today, pooling experiments are driven by the potential cost savings and precision gains that can result, and they are making a substantial impact on blood screening and drug discovery. A general review of pooling experiments is given here, with additional details and discussion of issues and methods for two important application areas, namely, blood testing and drug discovery. Recognizing that developing countries can ill-afford the cost of 100% one-at-a-time screening, WHO issued recommendations for testing for HIV antibody on serum pools (WHO, 1991) in areas where seroprevalence is less than 2%. Since the late 1980s, statistical contributions to pooling for blood testing have focused on the following aspects: assessing changes in sensitivity and specificity due to pooling, designing pooling strategies to accommodate both cheap initial screens and gold-standard confirmatory screens, and estimation of covariate-dependent prevalences. On the information and accuracy of pooled testing in estimating prevalence of a rare disease: Application to HIV screening	./cache/cord-017439-0c6ohmmg.txt	./txt/cord-017439-0c6ohmmg.txt