id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010689-d2qn1doq	Chehardoli, Gholamabbas	Synthetic strategies, SAR studies, and computer modeling of indole 2 and 3-carboxamides as the strong enzyme inhibitors: a review	2020-05-12		.txt	text/plain	6179	348	42	In this review, synthetic strategies of indole 2 and 3-carboxamide derivatives, the type, and mode of interaction of these derivatives against HLGP, HIV-1, renin enzyme, and structure–activity studies of these compounds were investigated. Based on our experiences on synthesis of various heterocycle compounds, such as: quinoxalines [15] , epoxides [16] , urazoles [17, 18] , pyrazolone [19] , benzoxazine [20] and especially the synthesis of 3H-indoles [21] , in this paper, we wish to present a comprehensive review about the synthesis, structure-activity relationship studies and computer modeling of indole 2 and 3-carboxamides as potent inhibitors of various enzymes. According to the results of docking calculations, the presences of indole ring and carboxamide moiety have a decisive role in the inhibitory activity of these compounds. According to the research conducted up to 2008, the presence of carboxamide moiety in the indole derivatives is essential for their inhibitory activity against HLGP.	./cache/cord-010689-d2qn1doq.txt	./txt/cord-010689-d2qn1doq.txt