id author title date pages extension mime words sentences flesch summary cache txt cord-009669-bcdjwpd1 Tsegaye, Theodros Solomon The multiple facets of HIV attachment to dendritic cell lectins 2010-09-20 .txt text/plain 4852 199 40 Trans-infection was reported to depend on DC-SIGNmediated binding and cellular uptake of HIV into dendritic cells (Geijtenbeek et al., 2000; Kwon et al., 2002) , followed by intracellular transport of virions to sites of dendritic cell-T cell contact, termed infectious synapses (McDonald et al., 2003) (Fig. 1) . Finally, signalling via TLR8 and DC-SIGN was required for NFkB-dependent recruitment of the transcription factor pTEF-b to the viral promoter, and thus for the generation of full-length HIV transcripts in dendritic cells -a prerequisite for productive infection (Gringhuis et al., 2010) (Fig. 2) . Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans-and cis-infection pathways Functionally distinct transmission of human immunodeficiency virus type 1 mediated by immature and mature dendritic cells ./cache/cord-009669-bcdjwpd1.txt ./txt/cord-009669-bcdjwpd1.txt