id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003715-deqiets2	Warren, Cody J.	Selective use of primate CD4 receptors by HIV-1	2019-06-10		.txt	text/plain	9529	457	55	We next tested HIV-1 pseudotyped with Envs from four macrophage-tropic viruses [31, [64] [65] [66] [67] [68] [69] [70] [71] [72] for their ability to infect cells bearing primate CD4 receptors ( Fig 3B) . (A, B) Cells stably expressing various primate CD4 receptors (x-axis), along with human CCR5, were infected with Q23ΔEnv-GFP pseudotyped with (A) early HIV-1 Envelopes (Envs) or (B) Envs from common macrophagetropic HIV-1 isolates. Collectively, these data suggest that most early HIV-1 isolates from the blood, which have lower affinity for human CD4 compared to macrophage-tropic viruses, do not bind well to chimpanzee and macaque CD4. In this study, we have shown that Envs from over 30 early and chronic HIV-1 isolates from human blood (mother-infant pairs, etc.) all demonstrate selective entry via only some primate CD4 receptors. (B) Dog thymocytes (Cf2Th cells) stably expressing human CCR5 and the indicated rhesus macaque CD4 alleles (x-axis) were infected with HIV-1 (Q23ΔEnv-GFP) bearing a subtype A (BG505) or subtype C (CAP210.2.00.E8) Envelope (Env).	./cache/cord-003715-deqiets2.txt	./txt/cord-003715-deqiets2.txt