id author title date pages extension mime words sentences flesch summary cache txt cord-259624-alor7ymh Brooks, Bryan W. Toxicology Advances for 21st Century Chemical Pollution 2020-04-24 .txt text/plain 3112 141 23 Fortunately, advances in comparative and predictive toxicologyincluding research and regulatory shifts toward in vitro and in silico approaches and the increasing use of alternative animal models (e.g., zebrafish embryos)are helping to address the ethical, economic, and time constraints of traditional toxicology while also advancing mechanistic understanding. In addition, these and other toxicology advances are being leveraged for prospective evaluations of diverse substances-including ingredients in consumer products, industrial chemicals, and pesticides-for human and ecological hazards and during retrospective assessments (e.g., effectdirected analysis) for the identification of pollutants and other stressors in aquatic and terrestrial ecosystems. 15 When AOPs are conserved across species, comparative and predictive toxicology efforts promise to further develop coupled ecological and human health hazard and risk assessments. Advances in comparative and predictive toxicology are providing mechanistic insights and tools for designing less hazardous chemicals before they enter commerce, identifying problematic substances currently in production, and diagnosing causes of chemical pollution. ./cache/cord-259624-alor7ymh.txt ./txt/cord-259624-alor7ymh.txt