id sid tid token lemma pos cord-273555-i1d4quos 1 1 key key NN cord-273555-i1d4quos 1 2 : : : cord-273555-i1d4quos 1 3 cord-273555-i1d4quos cord-273555-i1d4quos NN cord-273555-i1d4quos 1 4 authors author NNS cord-273555-i1d4quos 1 5 : : : cord-273555-i1d4quos 1 6 Stättermayer Stättermayer NNP cord-273555-i1d4quos 1 7 , , , cord-273555-i1d4quos 1 8 A. a. NN cord-273555-i1d4quos 1 9 F. f. NN cord-273555-i1d4quos 1 10 ; ; : cord-273555-i1d4quos 1 11 Ferenci Ferenci NNP cord-273555-i1d4quos 1 12 , , , cord-273555-i1d4quos 1 13 P. P. NNP cord-273555-i1d4quos 1 14 title title NN cord-273555-i1d4quos 1 15 : : : cord-273555-i1d4quos 2 1 Letter letter NN cord-273555-i1d4quos 2 2 : : : cord-273555-i1d4quos 2 3 does do VBZ cord-273555-i1d4quos 2 4 the the DT cord-273555-i1d4quos 2 5 IFNL4 IFNL4 NNP cord-273555-i1d4quos 2 6 gene gene NN cord-273555-i1d4quos 2 7 discovery discovery NN cord-273555-i1d4quos 2 8 really really RB cord-273555-i1d4quos 2 9 provide provide VBP cord-273555-i1d4quos 2 10 a a DT cord-273555-i1d4quos 2 11 causal causal JJ cord-273555-i1d4quos 2 12 role role NN cord-273555-i1d4quos 2 13 for for IN cord-273555-i1d4quos 2 14 the the DT cord-273555-i1d4quos 2 15 IL28B IL28B NNP cord-273555-i1d4quos 2 16 haplotype haplotype NN cord-273555-i1d4quos 2 17 blocks block NNS cord-273555-i1d4quos 2 18 ? ? . cord-273555-i1d4quos 3 1 Authors author NNS cord-273555-i1d4quos 3 2 ' ' POS cord-273555-i1d4quos 3 3 reply reply NN cord-273555-i1d4quos 3 4 date date NN cord-273555-i1d4quos 3 5 : : : cord-273555-i1d4quos 3 6 2014 2014 CD cord-273555-i1d4quos 3 7 - - HYPH cord-273555-i1d4quos 3 8 02 02 CD cord-273555-i1d4quos 3 9 - - HYPH cord-273555-i1d4quos 3 10 04 04 CD cord-273555-i1d4quos 3 11 journal journal NN cord-273555-i1d4quos 3 12 : : : cord-273555-i1d4quos 4 1 Aliment Aliment NNP cord-273555-i1d4quos 4 2 Pharmacol Pharmacol NNP cord-273555-i1d4quos 5 1 Ther ther JJ cord-273555-i1d4quos 5 2 DOI DOI NNP cord-273555-i1d4quos 5 3 : : : cord-273555-i1d4quos 6 1 10.1111 10.1111 CD cord-273555-i1d4quos 6 2 / / SYM cord-273555-i1d4quos 6 3 apt.12626 apt.12626 IN cord-273555-i1d4quos 7 1 sha sha NNP cord-273555-i1d4quos 7 2 : : : cord-273555-i1d4quos 8 1 eaf5a6543ccd555f3414c6dedc61edb79d439c27 eaf5a6543ccd555f3414c6dedc61edb79d439c27 NNP cord-273555-i1d4quos 8 2 doc_id doc_id NNP cord-273555-i1d4quos 9 1 : : : cord-273555-i1d4quos 9 2 273555 273555 CD cord-273555-i1d4quos 9 3 cord_uid cord_uid NNS cord-273555-i1d4quos 9 4 : : : cord-273555-i1d4quos 9 5 i1d4quos i1d4quos ADD cord-273555-i1d4quos 10 1 nan nan NNP cord-273555-i1d4quos 10 2 While while IN cord-273555-i1d4quos 10 3 IFNL4 IFNL4 NNP cord-273555-i1d4quos 10 4 variant variant NN cord-273555-i1d4quos 10 5 was be VBD cord-273555-i1d4quos 10 6 strongly strongly RB cord-273555-i1d4quos 10 7 associated associate VBN cord-273555-i1d4quos 10 8 with with IN cord-273555-i1d4quos 10 9 a a DT cord-273555-i1d4quos 10 10 sustained sustained JJ cord-273555-i1d4quos 10 11 virological virological JJ cord-273555-i1d4quos 10 12 response response NN cord-273555-i1d4quos 10 13 in in IN cord-273555-i1d4quos 10 14 both both CC cord-273555-i1d4quos 10 15 HCV HCV NNP cord-273555-i1d4quos 10 16 genotypes genotype NNS cord-273555-i1d4quos 10 17 1 1 CD cord-273555-i1d4quos 10 18 and and CC cord-273555-i1d4quos 10 19 4 4 CD cord-273555-i1d4quos 10 20 , , , cord-273555-i1d4quos 10 21 and and CC cord-273555-i1d4quos 10 22 thus thus RB cord-273555-i1d4quos 10 23 confirmed confirm VBD cord-273555-i1d4quos 10 24 previous previous JJ cord-273555-i1d4quos 10 25 findings finding NNS cord-273555-i1d4quos 10 26 by by IN cord-273555-i1d4quos 10 27 Prokunina Prokunina NNP cord-273555-i1d4quos 10 28 - - HYPH cord-273555-i1d4quos 10 29 Olsson Olsson NNP cord-273555-i1d4quos 10 30 et et NNP cord-273555-i1d4quos 10 31 al al NNP cord-273555-i1d4quos 10 32 . . . cord-273555-i1d4quos 11 1 2 2 CD cord-273555-i1d4quos 11 2 and and CC cord-273555-i1d4quos 11 3 Bibert Bibert NNP cord-273555-i1d4quos 11 4 et et NNP cord-273555-i1d4quos 11 5 al al NNP cord-273555-i1d4quos 11 6 . . . cord-273555-i1d4quos 12 1 , , , cord-273555-i1d4quos 12 2 3 3 CD cord-273555-i1d4quos 12 3 the the DT cord-273555-i1d4quos 12 4 study study NN cord-273555-i1d4quos 12 5 confirms confirm VBZ cord-273555-i1d4quos 12 6 a a DT cord-273555-i1d4quos 12 7 strong strong JJ cord-273555-i1d4quos 12 8 linkage linkage NN cord-273555-i1d4quos 12 9 between between IN cord-273555-i1d4quos 12 10 ss469415590 ss469415590 NNP cord-273555-i1d4quos 12 11 and and CC cord-273555-i1d4quos 12 12 rs12979860 rs12979860 NN cord-273555-i1d4quos 12 13 variants variant NNS cord-273555-i1d4quos 12 14 ( ( -LRB- cord-273555-i1d4quos 12 15 q q NNP cord-273555-i1d4quos 12 16 = = NNP cord-273555-i1d4quos 12 17 0.988 0.988 CD cord-273555-i1d4quos 12 18 ) ) -RRB- cord-273555-i1d4quos 12 19 compared compare VBN cord-273555-i1d4quos 12 20 with with IN cord-273555-i1d4quos 12 21 the the DT cord-273555-i1d4quos 12 22 modest modest JJ cord-273555-i1d4quos 12 23 correlation correlation NN cord-273555-i1d4quos 12 24 between between IN cord-273555-i1d4quos 12 25 rs8099917 rs8099917 NNP cord-273555-i1d4quos 12 26 and and CC cord-273555-i1d4quos 12 27 IFNL4 ifnl4 XX cord-273555-i1d4quos 13 1 ( ( -LRB- cord-273555-i1d4quos 13 2 q q NNP cord-273555-i1d4quos 13 3 = = NNP cord-273555-i1d4quos 13 4 0.598 0.598 CD cord-273555-i1d4quos 13 5 ) ) -RRB- cord-273555-i1d4quos 13 6 . . . cord-273555-i1d4quos 14 1 These these DT cord-273555-i1d4quos 14 2 findings finding NNS cord-273555-i1d4quos 14 3 therefore therefore RB cord-273555-i1d4quos 14 4 do do VBP cord-273555-i1d4quos 14 5 not not RB cord-273555-i1d4quos 14 6 support support VB cord-273555-i1d4quos 14 7 an an DT cord-273555-i1d4quos 14 8 additional additional JJ cord-273555-i1d4quos 14 9 clinical clinical JJ cord-273555-i1d4quos 14 10 benefit benefit NN cord-273555-i1d4quos 14 11 of of IN cord-273555-i1d4quos 14 12 IFNL4 ifnl4 NN cord-273555-i1d4quos 14 13 in in IN cord-273555-i1d4quos 14 14 the the DT cord-273555-i1d4quos 14 15 prediction prediction NN cord-273555-i1d4quos 14 16 of of IN cord-273555-i1d4quos 14 17 a a DT cord-273555-i1d4quos 14 18 response response NN cord-273555-i1d4quos 14 19 to to IN cord-273555-i1d4quos 14 20 PEG/ PEG/ NNP cord-273555-i1d4quos 14 21 RBV RBV NNP cord-273555-i1d4quos 14 22 in in IN cord-273555-i1d4quos 14 23 Caucasian caucasian JJ cord-273555-i1d4quos 14 24 patients patient NNS cord-273555-i1d4quos 14 25 . . . cord-273555-i1d4quos 15 1 Recently recently RB cord-273555-i1d4quos 15 2 , , , cord-273555-i1d4quos 15 3 the the DT cord-273555-i1d4quos 15 4 finding finding NN cord-273555-i1d4quos 15 5 that that IN cord-273555-i1d4quos 15 6 recombinant recombinant JJ cord-273555-i1d4quos 15 7 IFNL4 ifnl4 NN cord-273555-i1d4quos 15 8 protein protein NN cord-273555-i1d4quos 15 9 exerts exert VBZ cord-273555-i1d4quos 15 10 a a DT cord-273555-i1d4quos 15 11 potent potent JJ cord-273555-i1d4quos 15 12 antiviral antiviral JJ cord-273555-i1d4quos 15 13 activity activity NN cord-273555-i1d4quos 15 14 against against IN cord-273555-i1d4quos 15 15 both both CC cord-273555-i1d4quos 15 16 HCV HCV NNP cord-273555-i1d4quos 15 17 and and CC cord-273555-i1d4quos 15 18 human human JJ cord-273555-i1d4quos 15 19 coronaviruses coronaviruse NNS cord-273555-i1d4quos 15 20 4 4 CD cord-273555-i1d4quos 15 21 works work NNS cord-273555-i1d4quos 15 22 against against IN cord-273555-i1d4quos 15 23 the the DT cord-273555-i1d4quos 15 24 assumption assumption NN cord-273555-i1d4quos 15 25 that that IN cord-273555-i1d4quos 15 26 the the DT cord-273555-i1d4quos 15 27 same same JJ cord-273555-i1d4quos 15 28 protein protein NN cord-273555-i1d4quos 15 29 does do VBZ cord-273555-i1d4quos 15 30 inhibit inhibit VB cord-273555-i1d4quos 15 31 clearance clearance NN cord-273555-i1d4quos 15 32 of of IN cord-273555-i1d4quos 15 33 HCV HCV NNP cord-273555-i1d4quos 15 34 , , , cord-273555-i1d4quos 15 35 i.e. i.e. FW cord-273555-i1d4quos 15 36 negatively negatively RB cord-273555-i1d4quos 15 37 interfering interfere VBG cord-273555-i1d4quos 15 38 with with IN cord-273555-i1d4quos 15 39 HCV HCV NNP cord-273555-i1d4quos 15 40 infection infection NN cord-273555-i1d4quos 15 41 , , , cord-273555-i1d4quos 15 42 while while IN cord-273555-i1d4quos 15 43 being be VBG cord-273555-i1d4quos 15 44 endowed endow VBN cord-273555-i1d4quos 15 45 with with IN cord-273555-i1d4quos 15 46 a a DT cord-273555-i1d4quos 15 47 strong strong JJ cord-273555-i1d4quos 15 48 anti anti JJ cord-273555-i1d4quos 15 49 - - JJ cord-273555-i1d4quos 15 50 HCV hcv JJ cord-273555-i1d4quos 15 51 activity activity NN cord-273555-i1d4quos 15 52 . . . cord-273555-i1d4quos 16 1 This this DT cord-273555-i1d4quos 16 2 suggests suggest VBZ cord-273555-i1d4quos 16 3 the the DT cord-273555-i1d4quos 16 4 existence existence NN cord-273555-i1d4quos 16 5 of of IN cord-273555-i1d4quos 16 6 a a DT cord-273555-i1d4quos 16 7 complex complex JJ cord-273555-i1d4quos 16 8 relationship relationship NN cord-273555-i1d4quos 16 9 between between IN cord-273555-i1d4quos 16 10 IFNL4 IFNL4 NNP cord-273555-i1d4quos 16 11 and and CC cord-273555-i1d4quos 16 12 HCV HCV NNP cord-273555-i1d4quos 16 13 in in IN cord-273555-i1d4quos 16 14 humans human NNS cord-273555-i1d4quos 16 15 , , , cord-273555-i1d4quos 16 16 similar similar JJ cord-273555-i1d4quos 16 17 to to IN cord-273555-i1d4quos 16 18 that that DT cord-273555-i1d4quos 16 19 recently recently RB cord-273555-i1d4quos 16 20 described describe VBN cord-273555-i1d4quos 16 21 for for IN cord-273555-i1d4quos 16 22 IFN-1 IFN-1 NNP cord-273555-i1d4quos 16 23 and and CC cord-273555-i1d4quos 16 24 lymphocytic lymphocytic JJ cord-273555-i1d4quos 16 25 choriomeningitis choriomeningitis NNP cord-273555-i1d4quos 16 26 virus virus NN cord-273555-i1d4quos 16 27 in in IN cord-273555-i1d4quos 16 28 mice mouse NNS cord-273555-i1d4quos 16 29 , , , cord-273555-i1d4quos 16 30 5 5 CD cord-273555-i1d4quos 16 31 where where WRB cord-273555-i1d4quos 16 32 chronic chronic JJ cord-273555-i1d4quos 16 33 IFN IFN NNP cord-273555-i1d4quos 16 34 - - HYPH cord-273555-i1d4quos 16 35 I I NNP cord-273555-i1d4quos 16 36 signalling signal VBG cord-273555-i1d4quos 16 37 due due IN cord-273555-i1d4quos 16 38 to to IN cord-273555-i1d4quos 16 39 persistent persistent JJ cord-273555-i1d4quos 16 40 infection infection NN cord-273555-i1d4quos 16 41 drives drive VBZ cord-273555-i1d4quos 16 42 immunosuppression immunosuppression NN cord-273555-i1d4quos 16 43 and and CC cord-273555-i1d4quos 16 44 disease disease NN cord-273555-i1d4quos 16 45 progression progression NN cord-273555-i1d4quos 16 46 . . . cord-273555-i1d4quos 17 1 Although although IN cord-273555-i1d4quos 17 2 validation validation NN cord-273555-i1d4quos 17 3 studies study NNS cord-273555-i1d4quos 17 4 in in IN cord-273555-i1d4quos 17 5 large large JJ cord-273555-i1d4quos 17 6 cohorts cohort NNS cord-273555-i1d4quos 17 7 of of IN cord-273555-i1d4quos 17 8 patients patient NNS cord-273555-i1d4quos 17 9 , , , cord-273555-i1d4quos 17 10 like like IN cord-273555-i1d4quos 17 11 the the DT cord-273555-i1d4quos 17 12 one one NN cord-273555-i1d4quos 17 13 investigated investigate VBN cord-273555-i1d4quos 17 14 by by IN cord-273555-i1d4quos 17 15 St€ St€ NNP cord-273555-i1d4quos 17 16 attermayer attermayer NNP cord-273555-i1d4quos 17 17 et et NNP cord-273555-i1d4quos 17 18 al al NNP cord-273555-i1d4quos 18 1 . . . cord-273555-i1d4quos 19 1 , , , cord-273555-i1d4quos 19 2 1 1 CD cord-273555-i1d4quos 19 3 may may MD cord-273555-i1d4quos 19 4 help help VB cord-273555-i1d4quos 19 5 understand understand VB cord-273555-i1d4quos 19 6 the the DT cord-273555-i1d4quos 19 7 clinical clinical JJ cord-273555-i1d4quos 19 8 utility utility NN cord-273555-i1d4quos 19 9 of of IN cord-273555-i1d4quos 19 10 IFNL4 ifnl4 NN cord-273555-i1d4quos 19 11 , , , cord-273555-i1d4quos 19 12 these these DT cord-273555-i1d4quos 19 13 studies study NNS cord-273555-i1d4quos 19 14 have have VBP cord-273555-i1d4quos 19 15 so so RB cord-273555-i1d4quos 19 16 far far RB cord-273555-i1d4quos 19 17 failed fail VBN cord-273555-i1d4quos 19 18 to to TO cord-273555-i1d4quos 19 19 demonstrate demonstrate VB cord-273555-i1d4quos 19 20 any any DT cord-273555-i1d4quos 19 21 causal causal JJ cord-273555-i1d4quos 19 22 rela rela JJ cord-273555-i1d4quos 19 23 - - HYPH cord-273555-i1d4quos 19 24 tionship tionship NN cord-273555-i1d4quos 19 25 between between IN cord-273555-i1d4quos 19 26 IFNL4 ifnl4 NN cord-273555-i1d4quos 19 27 protein protein NN cord-273555-i1d4quos 19 28 and and CC cord-273555-i1d4quos 19 29 nonresponse nonresponse NN cord-273555-i1d4quos 19 30 to to IN cord-273555-i1d4quos 19 31 interferon interferon NN cord-273555-i1d4quos 19 32 therapy therapy NN cord-273555-i1d4quos 19 33 in in IN cord-273555-i1d4quos 19 34 chronic chronic JJ cord-273555-i1d4quos 19 35 HCV HCV NNP cord-273555-i1d4quos 19 36 patients patient NNS cord-273555-i1d4quos 19 37 . . . cord-273555-i1d4quos 20 1 Among among IN cord-273555-i1d4quos 20 2 other other JJ cord-273555-i1d4quos 20 3 approaches approach NNS cord-273555-i1d4quos 20 4 , , , cord-273555-i1d4quos 20 5 the the DT cord-273555-i1d4quos 20 6 assessment assessment NN cord-273555-i1d4quos 20 7 of of IN cord-273555-i1d4quos 20 8 the the DT cord-273555-i1d4quos 20 9 missense missense NN cord-273555-i1d4quos 20 10 variants variant NNS cord-273555-i1d4quos 20 11 previously previously RB cord-273555-i1d4quos 20 12 described describe VBN cord-273555-i1d4quos 20 13 in in IN cord-273555-i1d4quos 20 14 the the DT cord-273555-i1d4quos 20 15 IFNL4 ifnl4 NN cord-273555-i1d4quos 20 16 coding code VBG cord-273555-i1d4quos 20 17 region region NN cord-273555-i1d4quos 20 18 , , , cord-273555-i1d4quos 20 19 2 2 CD cord-273555-i1d4quos 20 20 may may MD cord-273555-i1d4quos 20 21 help help VB cord-273555-i1d4quos 20 22 unravel unravel VB cord-273555-i1d4quos 20 23 this this DT cord-273555-i1d4quos 20 24 issue issue NN cord-273555-i1d4quos 20 25 . . . cord-273555-i1d4quos 21 1 Letter letter NN cord-273555-i1d4quos 21 2 : : : cord-273555-i1d4quos 21 3 does do VBZ cord-273555-i1d4quos 21 4 the the DT cord-273555-i1d4quos 21 5 IFNL4 IFNL4 NNP cord-273555-i1d4quos 21 6 gene gene NN cord-273555-i1d4quos 21 7 discovery discovery NN cord-273555-i1d4quos 21 8 really really RB cord-273555-i1d4quos 21 9 provide provide VBP cord-273555-i1d4quos 21 10 a a DT cord-273555-i1d4quos 21 11 causal causal JJ cord-273555-i1d4quos 21 12 role role NN cord-273555-i1d4quos 21 13 for for IN cord-273555-i1d4quos 21 14 the the DT cord-273555-i1d4quos 21 15 IL28B IL28B NNP cord-273555-i1d4quos 21 16 haplotype haplotype NN cord-273555-i1d4quos 21 17 blocks block NNS cord-273555-i1d4quos 21 18 ? ? . cord-273555-i1d4quos 22 1 Authors author NNS cord-273555-i1d4quos 22 2 ' ' POS cord-273555-i1d4quos 22 3 reply reply NN cord-273555-i1d4quos 22 4 SIRS sirs UH cord-273555-i1d4quos 22 5 , , , cord-273555-i1d4quos 22 6 We -PRON- PRP cord-273555-i1d4quos 22 7 thank thank VBP cord-273555-i1d4quos 22 8 Dr Dr NNP cord-273555-i1d4quos 22 9 Galmozzi Galmozzi NNP cord-273555-i1d4quos 22 10 and and CC cord-273555-i1d4quos 22 11 Dr Dr NNP cord-273555-i1d4quos 22 12 Lampertico Lampertico NNP cord-273555-i1d4quos 22 13 for for IN cord-273555-i1d4quos 22 14 their -PRON- PRP$ cord-273555-i1d4quos 22 15 comment comment NN cord-273555-i1d4quos 22 16 on on IN cord-273555-i1d4quos 22 17 our -PRON- PRP$ cord-273555-i1d4quos 22 18 recently recently RB cord-273555-i1d4quos 22 19 published publish VBN cord-273555-i1d4quos 22 20 paper paper NN cord-273555-i1d4quos 22 21 on on IN cord-273555-i1d4quos 22 22 the the DT cord-273555-i1d4quos 22 23 effect effect NN cord-273555-i1d4quos 22 24 of of IN cord-273555-i1d4quos 22 25 the the DT cord-273555-i1d4quos 22 26 dinucleotide dinucleotide NN cord-273555-i1d4quos 22 27 frameshift frameshift NN cord-273555-i1d4quos 22 28 variant variant NN cord-273555-i1d4quos 22 29 in in IN cord-273555-i1d4quos 22 30 ss469415590 ss469415590 NNP cord-273555-i1d4quos 22 31 in in IN cord-273555-i1d4quos 22 32 the the DT cord-273555-i1d4quos 22 33 interferon interferon NN cord-273555-i1d4quos 22 34 ( ( -LRB- cord-273555-i1d4quos 22 35 IFN)-k4 IFN)-k4 NNP cord-273555-i1d4quos 22 36 gene gene NN cord-273555-i1d4quos 22 37 on on IN cord-273555-i1d4quos 22 38 interferon interferon NN cord-273555-i1d4quos 22 39 / / SYM cord-273555-i1d4quos 22 40 ribavirin ribavirin NN cord-273555-i1d4quos 22 41 treatment treatment NN cord-273555-i1d4quos 22 42 and and CC cord-273555-i1d4quos 22 43 its -PRON- PRP$ cord-273555-i1d4quos 22 44 relationship relationship NN cord-273555-i1d4quos 22 45 with with IN cord-273555-i1d4quos 22 46 the the DT cord-273555-i1d4quos 22 47 two two CD cord-273555-i1d4quos 22 48 commonly commonly RB cord-273555-i1d4quos 22 49 used use VBN cord-273555-i1d4quos 22 50 single single JJ cord-273555-i1d4quos 22 51 nucleotide nucleotide JJ cord-273555-i1d4quos 22 52 polymorphisms polymorphism NNS cord-273555-i1d4quos 22 53 ( ( -LRB- cord-273555-i1d4quos 22 54 SNP SNP NNP cord-273555-i1d4quos 22 55 ) ) -RRB- cord-273555-i1d4quos 22 56 in in IN cord-273555-i1d4quos 22 57 IL28B IL28B NNP cord-273555-i1d4quos 22 58 ( ( -LRB- cord-273555-i1d4quos 22 59 rs12979860 rs12979860 NNP cord-273555-i1d4quos 22 60 , , , cord-273555-i1d4quos 22 61 rs8099917 rs8099917 LS cord-273555-i1d4quos 22 62 ) ) -RRB- cord-273555-i1d4quos 22 63 . . . cord-273555-i1d4quos 23 1 1 1 CD cord-273555-i1d4quos 23 2 , , , cord-273555-i1d4quos 23 3 2 2 CD cord-273555-i1d4quos 23 4 We -PRON- PRP cord-273555-i1d4quos 23 5 agree agree VBP cord-273555-i1d4quos 23 6 that that IN cord-273555-i1d4quos 23 7 our -PRON- PRP$ cord-273555-i1d4quos 23 8 study study NN cord-273555-i1d4quos 23 9 does do VBZ cord-273555-i1d4quos 23 10 not not RB cord-273555-i1d4quos 23 11 provide provide VB cord-273555-i1d4quos 23 12 insights insight NNS cord-273555-i1d4quos 23 13 on on IN cord-273555-i1d4quos 23 14 the the DT cord-273555-i1d4quos 23 15 causal causal JJ cord-273555-i1d4quos 23 16 relationship relationship NN cord-273555-i1d4quos 23 17 between between IN cord-273555-i1d4quos 23 18 IFNL4 ifnl4 NN cord-273555-i1d4quos 23 19 and and CC cord-273555-i1d4quos 23 20 treatment treatment NN cord-273555-i1d4quos 23 21 response response NN cord-273555-i1d4quos 23 22 in in IN cord-273555-i1d4quos 23 23 patients patient NNS cord-273555-i1d4quos 23 24 with with IN cord-273555-i1d4quos 23 25 chronic chronic JJ cord-273555-i1d4quos 23 26 hepatitis hepatitis NN cord-273555-i1d4quos 23 27 C c NN cord-273555-i1d4quos 23 28 virus virus NN cord-273555-i1d4quos 23 29 ( ( -LRB- cord-273555-i1d4quos 23 30 HCV HCV NNP cord-273555-i1d4quos 23 31 ) ) -RRB- cord-273555-i1d4quos 23 32 infection infection NN cord-273555-i1d4quos 23 33 . . . cord-273555-i1d4quos 24 1 Nevertheless nevertheless RB cord-273555-i1d4quos 24 2 , , , cord-273555-i1d4quos 24 3 our -PRON- PRP$ cord-273555-i1d4quos 24 4 study study NN cord-273555-i1d4quos 24 5 was be VBD cord-273555-i1d4quos 24 6 designed design VBN cord-273555-i1d4quos 24 7 to to TO cord-273555-i1d4quos 24 8 investigate investigate VB cord-273555-i1d4quos 24 9 the the DT cord-273555-i1d4quos 24 10 clinical clinical JJ cord-273555-i1d4quos 24 11 usefulness usefulness NN cord-273555-i1d4quos 24 12 of of IN cord-273555-i1d4quos 24 13 the the DT cord-273555-i1d4quos 24 14 different different JJ cord-273555-i1d4quos 24 15 SNPs snp NNS cord-273555-i1d4quos 24 16 in in IN cord-273555-i1d4quos 24 17 IL28B IL28B NNP cord-273555-i1d4quos 25 1 and and CC cord-273555-i1d4quos 25 2 IFNL4 ifnl4 RB cord-273555-i1d4quos 25 3 in in IN cord-273555-i1d4quos 25 4 a a DT cord-273555-i1d4quos 25 5 large large JJ cord-273555-i1d4quos 25 6 cohort cohort NN cord-273555-i1d4quos 25 7 of of IN cord-273555-i1d4quos 25 8 Caucasian caucasian JJ cord-273555-i1d4quos 25 9 patients patient NNS cord-273555-i1d4quos 25 10 infected infect VBN cord-273555-i1d4quos 25 11 with with IN cord-273555-i1d4quos 25 12 chronic chronic JJ cord-273555-i1d4quos 25 13 HCV HCV NNP cord-273555-i1d4quos 25 14 . . . cord-273555-i1d4quos 26 1 Hamming Hamming NNP cord-273555-i1d4quos 26 2 et et FW cord-273555-i1d4quos 26 3 al al NNP cord-273555-i1d4quos 26 4 . . . cord-273555-i1d4quos 27 1 demonstrated demonstrate VBD cord-273555-i1d4quos 27 2 that that IN cord-273555-i1d4quos 27 3 IFNL4 ifnl4 PRP cord-273555-i1d4quos 27 4 encodes encode VBZ cord-273555-i1d4quos 27 5 an an DT cord-273555-i1d4quos 27 6 active active JJ cord-273555-i1d4quos 27 7 type type NN cord-273555-i1d4quos 27 8 III iii CD cord-273555-i1d4quos 27 9 interferon interferon NN cord-273555-i1d4quos 27 10 with with IN cord-273555-i1d4quos 27 11 potent potent JJ cord-273555-i1d4quos 27 12 anti anti JJ cord-273555-i1d4quos 27 13 - - JJ cord-273555-i1d4quos 27 14 viral viral JJ cord-273555-i1d4quos 27 15 activity activity NN cord-273555-i1d4quos 27 16 against against IN cord-273555-i1d4quos 27 17 both both CC cord-273555-i1d4quos 27 18 HCV HCV NNP cord-273555-i1d4quos 27 19 and and CC cord-273555-i1d4quos 27 20 coronaviruses coronaviruse NNS cord-273555-i1d4quos 27 21 . . . cord-273555-i1d4quos 28 1 3 3 CD cord-273555-i1d4quos 28 2 Galmozzi Galmozzi NNP cord-273555-i1d4quos 28 3 and and CC cord-273555-i1d4quos 28 4 Lampertico Lampertico NNP cord-273555-i1d4quos 28 5 therefore therefore RB cord-273555-i1d4quos 28 6 conclude conclude VBP cord-273555-i1d4quos 28 7 that that IN cord-273555-i1d4quos 28 8 this this DT cord-273555-i1d4quos 28 9 strong strong JJ cord-273555-i1d4quos 28 10 anti anti JJ cord-273555-i1d4quos 28 11 - - JJ cord-273555-i1d4quos 28 12 viral viral JJ cord-273555-i1d4quos 28 13 activity activity NN cord-273555-i1d4quos 28 14 works work VBZ cord-273555-i1d4quos 28 15 against against IN cord-273555-i1d4quos 28 16 the the DT cord-273555-i1d4quos 28 17 assumption assumption NN cord-273555-i1d4quos 28 18 of of IN cord-273555-i1d4quos 28 19 an an DT cord-273555-i1d4quos 28 20 inhibition inhibition NN cord-273555-i1d4quos 28 21 of of IN cord-273555-i1d4quos 28 22 the the DT cord-273555-i1d4quos 28 23 IFNL4 IFNL4 NNP cord-273555-i1d4quos 28 24 protein protein NN cord-273555-i1d4quos 28 25 of of IN cord-273555-i1d4quos 28 26 treatment treatment NN cord-273555-i1d4quos 28 27 - - HYPH cord-273555-i1d4quos 28 28 induced induce VBN cord-273555-i1d4quos 28 29 HCV HCV NNP cord-273555-i1d4quos 28 30 clearance clearance NN cord-273555-i1d4quos 28 31 . . . cord-273555-i1d4quos 29 1 We -PRON- PRP cord-273555-i1d4quos 29 2 would would MD cord-273555-i1d4quos 29 3 like like VB cord-273555-i1d4quos 29 4 to to TO cord-273555-i1d4quos 29 5 remind remind VB cord-273555-i1d4quos 29 6 them -PRON- PRP cord-273555-i1d4quos 29 7 that that IN cord-273555-i1d4quos 29 8 up up JJ cord-273555-i1d4quos 29 9 - - HYPH cord-273555-i1d4quos 29 10 regulation regulation NN cord-273555-i1d4quos 29 11 of of IN cord-273555-i1d4quos 29 12 intrahepatic intrahepatic JJ cord-273555-i1d4quos 29 13 interferon interferon NN cord-273555-i1d4quos 29 14 - - HYPH cord-273555-i1d4quos 29 15 stimulated stimulate VBN cord-273555-i1d4quos 29 16 genes gene NNS cord-273555-i1d4quos 29 17 ( ( -LRB- cord-273555-i1d4quos 29 18 ISG ISG NNP cord-273555-i1d4quos 29 19 ) ) -RRB- cord-273555-i1d4quos 29 20 is be VBZ cord-273555-i1d4quos 29 21 associated associate VBN cord-273555-i1d4quos 29 22 with with IN cord-273555-i1d4quos 29 23 treatment treatment NN cord-273555-i1d4quos 29 24 failure failure NN cord-273555-i1d4quos 29 25 in in IN cord-273555-i1d4quos 29 26 patients patient NNS cord-273555-i1d4quos 29 27 with with IN cord-273555-i1d4quos 29 28 chronic chronic JJ cord-273555-i1d4quos 29 29 HCV HCV NNP cord-273555-i1d4quos 29 30 , , , cord-273555-i1d4quos 29 31 and and CC cord-273555-i1d4quos 29 32 levels level NNS cord-273555-i1d4quos 29 33 of of IN cord-273555-i1d4quos 29 34 ISG ISG NNP cord-273555-i1d4quos 29 35 are be VBP cord-273555-i1d4quos 29 36 differently differently RB cord-273555-i1d4quos 29 37 distributed distribute VBN cord-273555-i1d4quos 29 38 according accord VBG cord-273555-i1d4quos 29 39 to to IN cord-273555-i1d4quos 29 40 different different JJ cord-273555-i1d4quos 29 41 IL28B il28b NN cord-273555-i1d4quos 29 42 genotypes genotype NNS cord-273555-i1d4quos 29 43 . . . cord-273555-i1d4quos 30 1 4 4 LS cord-273555-i1d4quos 31 1 Furthermore furthermore RB cord-273555-i1d4quos 31 2 , , , cord-273555-i1d4quos 31 3 Prokunina Prokunina NNP cord-273555-i1d4quos 31 4 - - HYPH cord-273555-i1d4quos 31 5 Olsson Olsson NNP cord-273555-i1d4quos 31 6 and and CC cord-273555-i1d4quos 31 7 her -PRON- PRP$ cord-273555-i1d4quos 31 8 collaborators collaborator NNS cord-273555-i1d4quos 31 9 demonstrated demonstrate VBD cord-273555-i1d4quos 31 10 that that IN cord-273555-i1d4quos 31 11 IFNL4 IFNL4 NNP cord-273555-i1d4quos 31 12 induces induce VBZ cord-273555-i1d4quos 31 13 ISG ISG NNP cord-273555-i1d4quos 31 14 expression expression NN cord-273555-i1d4quos 31 15 in in IN cord-273555-i1d4quos 31 16 HepG2 HepG2 NNP cord-273555-i1d4quos 31 17 hepatoma hepatoma NN cord-273555-i1d4quos 31 18 cells cell NNS cord-273555-i1d4quos 31 19 . . . cord-273555-i1d4quos 32 1 5 5 LS cord-273555-i1d4quos 33 1 Thus thus RB cord-273555-i1d4quos 33 2 , , , cord-273555-i1d4quos 33 3 high high JJ cord-273555-i1d4quos 33 4 baseline baseline NN cord-273555-i1d4quos 33 5 ISG ISG NNP cord-273555-i1d4quos 33 6 levels level NNS cord-273555-i1d4quos 33 7 might may MD cord-273555-i1d4quos 33 8 be be VB cord-273555-i1d4quos 33 9 associated associate VBN cord-273555-i1d4quos 33 10 with with IN cord-273555-i1d4quos 33 11 poor poor JJ cord-273555-i1d4quos 33 12 response response NN cord-273555-i1d4quos 33 13 to to IN cord-273555-i1d4quos 33 14 exogenous exogenous JJ cord-273555-i1d4quos 33 15 IFN IFN NNP cord-273555-i1d4quos 33 16 , , , cord-273555-i1d4quos 33 17 by by IN cord-273555-i1d4quos 33 18 exhausting exhaust VBG cord-273555-i1d4quos 33 19 the the DT cord-273555-i1d4quos 33 20 IFN IFN NNP cord-273555-i1d4quos 33 21 response response NN cord-273555-i1d4quos 33 22 pathways pathway NNS cord-273555-i1d4quos 33 23 . . . cord-273555-i1d4quos 34 1 6 6 CD cord-273555-i1d4quos 34 2 Finally finally RB cord-273555-i1d4quos 34 3 , , , cord-273555-i1d4quos 34 4 we -PRON- PRP cord-273555-i1d4quos 34 5 agree agree VBP cord-273555-i1d4quos 34 6 that that IN cord-273555-i1d4quos 34 7 the the DT cord-273555-i1d4quos 34 8 causal causal JJ cord-273555-i1d4quos 34 9 role role NN cord-273555-i1d4quos 34 10 of of IN cord-273555-i1d4quos 34 11 IFNL4 ifnl4 NN cord-273555-i1d4quos 34 12 genotypes genotype NNS cord-273555-i1d4quos 34 13 for for IN cord-273555-i1d4quos 34 14 viral viral JJ cord-273555-i1d4quos 34 15 clearance clearance NN cord-273555-i1d4quos 34 16 is be VBZ cord-273555-i1d4quos 34 17 conflicting conflict VBG cord-273555-i1d4quos 34 18 , , , cord-273555-i1d4quos 34 19 and and CC cord-273555-i1d4quos 34 20 further further JJ cord-273555-i1d4quos 34 21 studies study NNS cord-273555-i1d4quos 34 22 need need VBP cord-273555-i1d4quos 34 23 to to TO cord-273555-i1d4quos 34 24 be be VB cord-273555-i1d4quos 34 25 performed perform VBN cord-273555-i1d4quos 34 26 to to TO cord-273555-i1d4quos 34 27 elucidate elucidate VB cord-273555-i1d4quos 34 28 the the DT cord-273555-i1d4quos 34 29 molecular molecular JJ cord-273555-i1d4quos 34 30 mechanistic mechanistic JJ cord-273555-i1d4quos 34 31 relationship relationship NN cord-273555-i1d4quos 34 32 . . . cord-273555-i1d4quos 35 1 The the DT cord-273555-i1d4quos 35 2 authors author NNS cord-273555-i1d4quos 35 3 ' ' POS cord-273555-i1d4quos 35 4 declarations declaration NNS cord-273555-i1d4quos 35 5 of of IN cord-273555-i1d4quos 35 6 personal personal JJ cord-273555-i1d4quos 35 7 and and CC cord-273555-i1d4quos 35 8 financial financial JJ cord-273555-i1d4quos 35 9 interests interest NNS cord-273555-i1d4quos 35 10 are be VBP cord-273555-i1d4quos 35 11 unchanged unchanged JJ cord-273555-i1d4quos 35 12 from from IN cord-273555-i1d4quos 35 13 those those DT cord-273555-i1d4quos 35 14 in in IN cord-273555-i1d4quos 35 15 the the DT cord-273555-i1d4quos 35 16 original original JJ cord-273555-i1d4quos 35 17 article article NN cord-273555-i1d4quos 35 18 . . . cord-273555-i1d4quos 36 1 2 2 LS cord-273555-i1d4quos 36 2 SIRS sirs UH cord-273555-i1d4quos 36 3 , , , cord-273555-i1d4quos 36 4 Bager Bager NNP cord-273555-i1d4quos 36 5 et et NNP cord-273555-i1d4quos 36 6 al al NNP cord-273555-i1d4quos 36 7 . . . cord-273555-i1d4quos 37 1 1 1 CD cord-273555-i1d4quos 37 2 reported report VBD cord-273555-i1d4quos 37 3 a a DT cord-273555-i1d4quos 37 4 randomised randomised JJ cord-273555-i1d4quos 37 5 controlled control VBN cord-273555-i1d4quos 37 6 trial trial NN cord-273555-i1d4quos 37 7 comparing compare VBG cord-273555-i1d4quos 37 8 oral oral JJ cord-273555-i1d4quos 37 9 ( ( -LRB- cord-273555-i1d4quos 37 10 100 100 CD cord-273555-i1d4quos 37 11 mg mg NNS cord-273555-i1d4quos 37 12 twice twice RB cord-273555-i1d4quos 37 13 daily daily JJ cord-273555-i1d4quos 37 14 ferrous ferrous JJ cord-273555-i1d4quos 37 15 sulphate sulphate NN cord-273555-i1d4quos 37 16 for for IN cord-273555-i1d4quos 37 17 3 3 CD cord-273555-i1d4quos 37 18 months month NNS cord-273555-i1d4quos 37 19 ) ) -RRB- cord-273555-i1d4quos 37 20 or or CC cord-273555-i1d4quos 37 21 intravenous intravenous JJ cord-273555-i1d4quos 37 22 ( ( -LRB- cord-273555-i1d4quos 37 23 1000 1000 CD cord-273555-i1d4quos 37 24 mg mg NNP cord-273555-i1d4quos 37 25 ferric ferric JJ cord-273555-i1d4quos 37 26 carboxymaltose carboxymaltose NNP cord-273555-i1d4quos 37 27 , , , cord-273555-i1d4quos 37 28 single single JJ cord-273555-i1d4quos 37 29 - - HYPH cord-273555-i1d4quos 37 30 dose dose NN cord-273555-i1d4quos 37 31 infusion infusion NN cord-273555-i1d4quos 37 32 ) ) -RRB- cord-273555-i1d4quos 38 1 iron iron NN cord-273555-i1d4quos 38 2 supplementation supplementation NN cord-273555-i1d4quos 38 3 and and CC cord-273555-i1d4quos 38 4 placebo placebo NN cord-273555-i1d4quos 38 5 for for IN cord-273555-i1d4quos 38 6 anaemia anaemia NN cord-273555-i1d4quos 38 7 after after IN cord-273555-i1d4quos 38 8 nonvariceal nonvariceal JJ cord-273555-i1d4quos 38 9 upper upper JJ cord-273555-i1d4quos 38 10 gastrointestinal gastrointestinal JJ cord-273555-i1d4quos 38 11 ( ( -LRB- cord-273555-i1d4quos 38 12 GI GI NNP cord-273555-i1d4quos 38 13 ) ) -RRB- cord-273555-i1d4quos 38 14 bleeding bleed VBG cord-273555-i1d4quos 38 15 . . . cord-273555-i1d4quos 39 1 Peptic peptic JJ cord-273555-i1d4quos 39 2 ulcers ulcer NNS cord-273555-i1d4quos 39 3 were be VBD cord-273555-i1d4quos 39 4 the the DT cord-273555-i1d4quos 39 5 most most RBS cord-273555-i1d4quos 39 6 common common JJ cord-273555-i1d4quos 39 7 sources source NNS cord-273555-i1d4quos 39 8 of of IN cord-273555-i1d4quos 39 9 bleeding bleed VBG cord-273555-i1d4quos 39 10 ( ( -LRB- cord-273555-i1d4quos 39 11 70 70 CD cord-273555-i1d4quos 39 12 % % NN cord-273555-i1d4quos 39 13 ) ) -RRB- cord-273555-i1d4quos 39 14 . . . cord-273555-i1d4quos 40 1 Patients patient NNS cord-273555-i1d4quos 40 2 in in IN cord-273555-i1d4quos 40 3 the the DT cord-273555-i1d4quos 40 4 placebo placebo NN cord-273555-i1d4quos 40 5 group group NN cord-273555-i1d4quos 40 6 prematurely prematurely RB cord-273555-i1d4quos 40 7 discontinued discontinue VBD cord-273555-i1d4quos 40 8 the the DT cord-273555-i1d4quos 40 9 study study NN cord-273555-i1d4quos 40 10 medication medication NN cord-273555-i1d4quos 40 11 because because IN cord-273555-i1d4quos 40 12 25 25 CD cord-273555-i1d4quos 40 13 % % NN cord-273555-i1d4quos 40 14 of of IN cord-273555-i1d4quos 40 15 patients patient NNS cord-273555-i1d4quos 40 16 were be VBD cord-273555-i1d4quos 40 17 still still RB cord-273555-i1d4quos 40 18 anaemic anaemic JJ cord-273555-i1d4quos 40 19 at at IN cord-273555-i1d4quos 40 20 the the DT cord-273555-i1d4quos 40 21 end end NN cord-273555-i1d4quos 40 22 of of IN cord-273555-i1d4quos 40 23 the the DT cord-273555-i1d4quos 40 24 13-week 13-week JJ cord-273555-i1d4quos 40 25 follow follow NN cord-273555-i1d4quos 40 26 - - HYPH cord-273555-i1d4quos 40 27 up up NN cord-273555-i1d4quos 40 28 period period NN cord-273555-i1d4quos 40 29 and and CC cord-273555-i1d4quos 40 30 , , , cord-273555-i1d4quos 40 31 therefore therefore RB cord-273555-i1d4quos 40 32 , , , cord-273555-i1d4quos 40 33 required require VBD cord-273555-i1d4quos 40 34 rescue rescue NN cord-273555-i1d4quos 40 35 therapy therapy NN cord-273555-i1d4quos 40 36 . . . cord-273555-i1d4quos 41 1 The the DT cord-273555-i1d4quos 41 2 study study NN cord-273555-i1d4quos 41 3 shows show VBZ cord-273555-i1d4quos 41 4 that that IN cord-273555-i1d4quos 41 5 either either CC cord-273555-i1d4quos 41 6 oral oral JJ cord-273555-i1d4quos 41 7 or or CC cord-273555-i1d4quos 41 8 intravenous intravenous JJ cord-273555-i1d4quos 41 9 were be VBD cord-273555-i1d4quos 41 10 significantly significantly RB cord-273555-i1d4quos 41 11 more more RBR cord-273555-i1d4quos 41 12 effective effective JJ cord-273555-i1d4quos 41 13 than than IN cord-273555-i1d4quos 41 14 placebo placebo NN cord-273555-i1d4quos 41 15 to to TO cord-273555-i1d4quos 41 16 overcome overcome VB cord-273555-i1d4quos 41 17 anaemia anaemia NN cord-273555-i1d4quos 41 18 , , , cord-273555-i1d4quos 41 19 and and CC cord-273555-i1d4quos 41 20 iron iron NN cord-273555-i1d4quos 41 21 stores store NNS cord-273555-i1d4quos 41 22 were be VBD cord-273555-i1d4quos 41 23 more more RBR cord-273555-i1d4quos 41 24 effectively effectively RB cord-273555-i1d4quos 41 25 replenished replenish VBN cord-273555-i1d4quos 41 26 with with IN cord-273555-i1d4quos 41 27 intravenous intravenous JJ cord-273555-i1d4quos 41 28 iron iron NN cord-273555-i1d4quos 41 29 when when WRB cord-273555-i1d4quos 41 30 compared compare VBN cord-273555-i1d4quos 41 31 with with IN cord-273555-i1d4quos 41 32 oral oral JJ cord-273555-i1d4quos 41 33 . . . cord-273555-i1d4quos 42 1 On on IN cord-273555-i1d4quos 42 2 reading read VBG cord-273555-i1d4quos 42 3 the the DT cord-273555-i1d4quos 42 4 abstract abstract NN cord-273555-i1d4quos 42 5 , , , cord-273555-i1d4quos 42 6 one one PRP cord-273555-i1d4quos 42 7 may may MD cord-273555-i1d4quos 42 8 tend tend VB cord-273555-i1d4quos 42 9 to to TO cord-273555-i1d4quos 42 10 think think VB cord-273555-i1d4quos 42 11 the the DT cord-273555-i1d4quos 42 12 results result NNS cord-273555-i1d4quos 42 13 were be VBD cord-273555-i1d4quos 42 14 foreseeable foreseeable JJ cord-273555-i1d4quos 42 15 , , , cord-273555-i1d4quos 42 16 but but CC cord-273555-i1d4quos 42 17 this this DT cord-273555-i1d4quos 42 18 study study NN cord-273555-i1d4quos 42 19 deserves deserve VBZ cord-273555-i1d4quos 42 20 a a DT cord-273555-i1d4quos 42 21 higher high JJR cord-273555-i1d4quos 42 22 consideration consideration NN cord-273555-i1d4quos 42 23 . . . cord-273555-i1d4quos 43 1 The the DT cord-273555-i1d4quos 43 2 first first JJ cord-273555-i1d4quos 43 3 important important JJ cord-273555-i1d4quos 43 4 conclusion conclusion NN cord-273555-i1d4quos 43 5 we -PRON- PRP cord-273555-i1d4quos 43 6 can can MD cord-273555-i1d4quos 43 7 draw draw VB cord-273555-i1d4quos 43 8 is be VBZ cord-273555-i1d4quos 43 9 that that IN cord-273555-i1d4quos 43 10 no no DT cord-273555-i1d4quos 43 11 patient patient NN cord-273555-i1d4quos 43 12 should should MD cord-273555-i1d4quos 43 13 be be VB cord-273555-i1d4quos 43 14 discharged discharge VBN cord-273555-i1d4quos 43 15 after after IN cord-273555-i1d4quos 43 16 upper upper JJ cord-273555-i1d4quos 43 17 GI gi NN cord-273555-i1d4quos 43 18 bleeding bleed VBG cord-273555-i1d4quos 43 19 without without IN cord-273555-i1d4quos 43 20 iron iron NN cord-273555-i1d4quos 43 21 supplementation supplementation NN cord-273555-i1d4quos 43 22 whenever whenever WRB cord-273555-i1d4quos 43 23 anaemia anaemia NN cord-273555-i1d4quos 43 24 is be VBZ cord-273555-i1d4quos 43 25 present present JJ cord-273555-i1d4quos 43 26 . . . cord-273555-i1d4quos 44 1 Although although IN cord-273555-i1d4quos 44 2 logical logical JJ cord-273555-i1d4quos 44 3 , , , cord-273555-i1d4quos 44 4 this this DT cord-273555-i1d4quos 44 5 protocol protocol NN cord-273555-i1d4quos 44 6 is be VBZ cord-273555-i1d4quos 44 7 not not RB cord-273555-i1d4quos 44 8 applied apply VBN cord-273555-i1d4quos 44 9 in in IN cord-273555-i1d4quos 44 10 routine routine JJ cord-273555-i1d4quos 44 11 daily daily JJ cord-273555-i1d4quos 44 12 practice practice NN cord-273555-i1d4quos 44 13 , , , cord-273555-i1d4quos 44 14 and and CC cord-273555-i1d4quos 44 15 had have VBD cord-273555-i1d4quos 44 16 been be VBN cord-273555-i1d4quos 44 17 seldom seldom RB cord-273555-i1d4quos 44 18 addressed address VBN cord-273555-i1d4quos 44 19 in in IN cord-273555-i1d4quos 44 20 the the DT cord-273555-i1d4quos 44 21 literature literature NN cord-273555-i1d4quos 44 22 . . . cord-273555-i1d4quos 45 1 Intravenous intravenous JJ cord-273555-i1d4quos 45 2 iron iron NN cord-273555-i1d4quos 45 3 did do VBD cord-273555-i1d4quos 45 4 not not RB cord-273555-i1d4quos 45 5 lead lead VB cord-273555-i1d4quos 45 6 to to IN cord-273555-i1d4quos 45 7 better well JJR cord-273555-i1d4quos 45 8 results result NNS cord-273555-i1d4quos 45 9 at at IN cord-273555-i1d4quos 45 10 week week NN cord-273555-i1d4quos 45 11 1 1 CD cord-273555-i1d4quos 45 12 , , , cord-273555-i1d4quos 45 13 4 4 CD cord-273555-i1d4quos 45 14 or or CC cord-273555-i1d4quos 45 15 13 13 CD cord-273555-i1d4quos 45 16 when when WRB cord-273555-i1d4quos 45 17 compared compare VBN cord-273555-i1d4quos 45 18 with with IN cord-273555-i1d4quos 45 19 oral oral JJ cord-273555-i1d4quos 45 20 supplementation supplementation NN cord-273555-i1d4quos 45 21 , , , cord-273555-i1d4quos 45 22 even even RB cord-273555-i1d4quos 45 23 though though IN cord-273555-i1d4quos 45 24 only only RB cord-273555-i1d4quos 45 25 56 56 CD cord-273555-i1d4quos 45 26 % % NN cord-273555-i1d4quos 45 27 had have VBD cord-273555-i1d4quos 45 28 complete complete JJ cord-273555-i1d4quos 45 29 adherence adherence NN cord-273555-i1d4quos 45 30 to to IN cord-273555-i1d4quos 45 31 oral oral JJ cord-273555-i1d4quos 45 32 therapy therapy NN cord-273555-i1d4quos 45 33 . . . cord-273555-i1d4quos 46 1 At at IN cord-273555-i1d4quos 46 2 the the DT cord-273555-i1d4quos 46 3 very very RB cord-273555-i1d4quos 46 4 least least JJS cord-273555-i1d4quos 46 5 , , , cord-273555-i1d4quos 46 6 these these DT cord-273555-i1d4quos 46 7 findings finding NNS cord-273555-i1d4quos 46 8 seem seem VBP cord-273555-i1d4quos 46 9 counterintuitive counterintuitive JJ cord-273555-i1d4quos 46 10 . . . cord-273555-i1d4quos 47 1 Whether whether IN cord-273555-i1d4quos 47 2 the the DT cord-273555-i1d4quos 47 3 efficacy efficacy NN cord-273555-i1d4quos 47 4 of of IN cord-273555-i1d4quos 47 5 oral oral JJ cord-273555-i1d4quos 47 6 iron iron NN cord-273555-i1d4quos 47 7 was be VBD cord-273555-i1d4quos 47 8 related relate VBN cord-273555-i1d4quos 47 9 to to IN cord-273555-i1d4quos 47 10 higher high JJR cord-273555-i1d4quos 47 11 intestinal intestinal JJ cord-273555-i1d4quos 47 12 absorption absorption NN cord-273555-i1d4quos 47 13 because because IN cord-273555-i1d4quos 47 14 of of IN cord-273555-i1d4quos 47 15 few few JJ cord-273555-i1d4quos 47 16 patients patient NNS cord-273555-i1d4quos 47 17 on on IN cord-273555-i1d4quos 47 18 proton proton NN cord-273555-i1d4quos 47 19 pump pump NN cord-273555-i1d4quos 47 20 inhibitor inhibitor NN cord-273555-i1d4quos 47 21 therapy therapy NN cord-273555-i1d4quos 47 22 ( ( -LRB- cord-273555-i1d4quos 47 23 17 17 CD cord-273555-i1d4quos 47 24 % % NN cord-273555-i1d4quos 47 25 ) ) -RRB- cord-273555-i1d4quos 47 26 , , , cord-273555-i1d4quos 47 27 even even RB cord-273555-i1d4quos 47 28 though though IN cord-273555-i1d4quos 47 29 peptic peptic JJ cord-273555-i1d4quos 47 30 ulcer ulcer NN cord-273555-i1d4quos 47 31 was be VBD cord-273555-i1d4quos 47 32 the the DT cord-273555-i1d4quos 47 33 most most RBS cord-273555-i1d4quos 47 34 common common JJ cord-273555-i1d4quos 47 35 cause cause NN cord-273555-i1d4quos 47 36 of of IN cord-273555-i1d4quos 47 37 GI GI NNP cord-273555-i1d4quos 47 38 bleeding bleeding NN cord-273555-i1d4quos 47 39 , , , cord-273555-i1d4quos 47 40 remains remain VBZ cord-273555-i1d4quos 47 41 unknown unknown JJ cord-273555-i1d4quos 47 42 . . . cord-273555-i1d4quos 48 1 In in IN cord-273555-i1d4quos 48 2 addition addition NN cord-273555-i1d4quos 48 3 , , , cord-273555-i1d4quos 48 4 oral oral JJ cord-273555-i1d4quos 48 5 iron iron NN cord-273555-i1d4quos 48 6 is be VBZ cord-273555-i1d4quos 48 7 notably notably RB cord-273555-i1d4quos 48 8 cheaper cheap JJR cord-273555-i1d4quos 48 9 . . . cord-273555-i1d4quos 49 1 This this DT cord-273555-i1d4quos 49 2 study study NN cord-273555-i1d4quos 49 3 highlights highlight VBZ cord-273555-i1d4quos 49 4 the the DT cord-273555-i1d4quos 49 5 importance importance NN cord-273555-i1d4quos 49 6 of of IN cord-273555-i1d4quos 49 7 iron iron NN cord-273555-i1d4quos 49 8 supplementation supplementation NN cord-273555-i1d4quos 49 9 after after IN cord-273555-i1d4quos 49 10 post post JJ cord-273555-i1d4quos 49 11 - - JJ cord-273555-i1d4quos 49 12 bleeding bleeding JJ cord-273555-i1d4quos 49 13 anaemia anaemia NN cord-273555-i1d4quos 49 14 , , , cord-273555-i1d4quos 49 15 with with IN cord-273555-i1d4quos 49 16 a a DT cord-273555-i1d4quos 49 17 clear clear JJ cord-273555-i1d4quos 49 18 cost cost NN cord-273555-i1d4quos 49 19 - - HYPH cord-273555-i1d4quos 49 20 effective effective JJ cord-273555-i1d4quos 49 21 advantage advantage NN cord-273555-i1d4quos 49 22 for for IN cord-273555-i1d4quos 49 23 oral oral JJ cord-273555-i1d4quos 49 24 administration administration NN cord-273555-i1d4quos 49 25 , , , cord-273555-i1d4quos 49 26 but but CC cord-273555-i1d4quos 49 27 with with IN cord-273555-i1d4quos 49 28 similar similar JJ cord-273555-i1d4quos 49 29 results result NNS cord-273555-i1d4quos 49 30 for for IN cord-273555-i1d4quos 49 31 the the DT cord-273555-i1d4quos 49 32 intravenous intravenous JJ cord-273555-i1d4quos 49 33 route route NN cord-273555-i1d4quos 49 34 in in IN cord-273555-i1d4quos 49 35 case case NN cord-273555-i1d4quos 49 36 of of IN cord-273555-i1d4quos 49 37 oral oral JJ cord-273555-i1d4quos 49 38 iron iron NN cord-273555-i1d4quos 49 39 intolerance intolerance NN cord-273555-i1d4quos 49 40 . . . cord-273555-i1d4quos 50 1 The the DT cord-273555-i1d4quos 50 2 results result NNS cord-273555-i1d4quos 50 3 are be VBP cord-273555-i1d4quos 50 4 especially especially RB cord-273555-i1d4quos 50 5 relevant relevant JJ cord-273555-i1d4quos 50 6 given give VBN cord-273555-i1d4quos 50 7 that that IN cord-273555-i1d4quos 50 8 restrictive restrictive JJ cord-273555-i1d4quos 50 9 transfusion transfusion NN cord-273555-i1d4quos 50 10 strategies strategy NNS cord-273555-i1d4quos 50 11 for for IN cord-273555-i1d4quos 50 12 upper upper JJ cord-273555-i1d4quos 50 13 GI gi NN cord-273555-i1d4quos 50 14 bleeding bleeding NN cord-273555-i1d4quos 50 15 ( ( -LRB- cord-273555-i1d4quos 50 16 transfusion transfusion NN cord-273555-i1d4quos 50 17 when when WRB cord-273555-i1d4quos 50 18 haemoglobin haemoglobin NN cord-273555-i1d4quos 50 19 level level NN cord-273555-i1d4quos 50 20 < < XX cord-273555-i1d4quos 50 21 7 7 CD cord-273555-i1d4quos 50 22 g g NN cord-273555-i1d4quos 50 23 / / SYM cord-273555-i1d4quos 50 24 dL dl NN cord-273555-i1d4quos 50 25 ) ) -RRB- cord-273555-i1d4quos 50 26 have have VBP cord-273555-i1d4quos 50 27 been be VBN cord-273555-i1d4quos 50 28 associated associate VBN cord-273555-i1d4quos 50 29 with with IN cord-273555-i1d4quos 50 30 better well JJR cord-273555-i1d4quos 50 31 outcomes outcome NNS cord-273555-i1d4quos 50 32 for for IN cord-273555-i1d4quos 50 33 nonvariceal nonvariceal JJ cord-273555-i1d4quos 50 34 upper upper JJ cord-273555-i1d4quos 50 35 GI GI NNP cord-273555-i1d4quos 50 36 bleeding bleed VBG cord-273555-i1d4quos 50 37 2 2 CD cord-273555-i1d4quos 50 38 . . . cord-273555-i1d4quos 51 1 In in IN cord-273555-i1d4quos 51 2 this this DT cord-273555-i1d4quos 51 3 context context NN cord-273555-i1d4quos 51 4 , , , cord-273555-i1d4quos 51 5 most most JJS cord-273555-i1d4quos 51 6 patients patient NNS cord-273555-i1d4quos 51 7 will will MD cord-273555-i1d4quos 51 8 be be VB cord-273555-i1d4quos 51 9 expected expect VBN cord-273555-i1d4quos 51 10 to to TO cord-273555-i1d4quos 51 11 be be VB cord-273555-i1d4quos 51 12 anaemic anaemic JJ cord-273555-i1d4quos 51 13 at at IN cord-273555-i1d4quos 51 14 discharge discharge NN cord-273555-i1d4quos 51 15 , , , cord-273555-i1d4quos 51 16 and and CC cord-273555-i1d4quos 51 17 this this DT cord-273555-i1d4quos 51 18 study study NN cord-273555-i1d4quos 51 19 sheds shed VBZ cord-273555-i1d4quos 51 20 light light NN cord-273555-i1d4quos 51 21 on on IN cord-273555-i1d4quos 51 22 the the DT cord-273555-i1d4quos 51 23 optimal optimal JJ cord-273555-i1d4quos 51 24 short short JJ cord-273555-i1d4quos 51 25 - - HYPH cord-273555-i1d4quos 51 26 term term NN cord-273555-i1d4quos 51 27 clinical clinical JJ cord-273555-i1d4quos 51 28 management management NN cord-273555-i1d4quos 51 29 regarding regard VBG cord-273555-i1d4quos 51 30 iron iron NN cord-273555-i1d4quos 51 31 supplementation supplementation NN cord-273555-i1d4quos 51 32 . . . cord-273555-i1d4quos 52 1 Declaration declaration NN cord-273555-i1d4quos 52 2 of of IN cord-273555-i1d4quos 52 3 personal personal JJ cord-273555-i1d4quos 52 4 and and CC cord-273555-i1d4quos 52 5 funding funding NN cord-273555-i1d4quos 52 6 interests interest NNS cord-273555-i1d4quos 52 7 : : : cord-273555-i1d4quos 52 8 None none NN cord-273555-i1d4quos 52 9 . . . cord-273555-i1d4quos 53 1 Polymorphisms polymorphism NNS cord-273555-i1d4quos 53 2 of of IN cord-273555-i1d4quos 53 3 interferon interferon NN cord-273555-i1d4quos 53 4 - - HYPH cord-273555-i1d4quos 53 5 k4 k4 NN cord-273555-i1d4quos 53 6 and and CC cord-273555-i1d4quos 53 7 IL28B il28b NN cord-273555-i1d4quos 53 8 -effects -effect NNS cord-273555-i1d4quos 53 9 on on IN cord-273555-i1d4quos 53 10 treatment treatment NN cord-273555-i1d4quos 53 11 response response NN cord-273555-i1d4quos 53 12 to to IN cord-273555-i1d4quos 53 13 interferon interferon NN cord-273555-i1d4quos 53 14 / / , cord-273555-i1d4quos 53 15 ribavirin ribavirin RB cord-273555-i1d4quos 53 16 in in IN cord-273555-i1d4quos 53 17 patients patient NNS cord-273555-i1d4quos 53 18 with with IN cord-273555-i1d4quos 53 19 chronic chronic JJ cord-273555-i1d4quos 53 20 hepatitis hepatitis NN cord-273555-i1d4quos 53 21 C C NNP cord-273555-i1d4quos 53 22 A A NNP cord-273555-i1d4quos 53 23 variant variant NN cord-273555-i1d4quos 53 24 upstream upstream NN cord-273555-i1d4quos 53 25 of of IN cord-273555-i1d4quos 53 26 IFNL3 ifnl3 XX cord-273555-i1d4quos 54 1 ( ( -LRB- cord-273555-i1d4quos 54 2 IL28B il28b NN cord-273555-i1d4quos 54 3 ) ) -RRB- cord-273555-i1d4quos 54 4 creating create VBG cord-273555-i1d4quos 54 5 a a DT cord-273555-i1d4quos 54 6 new new JJ cord-273555-i1d4quos 54 7 interferon interferon NN cord-273555-i1d4quos 54 8 gene gene NN cord-273555-i1d4quos 54 9 IFNL4 IFNL4 NNP cord-273555-i1d4quos 54 10 is be VBZ cord-273555-i1d4quos 54 11 associated associate VBN cord-273555-i1d4quos 54 12 with with IN cord-273555-i1d4quos 54 13 impaired impaired JJ cord-273555-i1d4quos 54 14 clearance clearance NN cord-273555-i1d4quos 54 15 of of IN cord-273555-i1d4quos 54 16 hepatitis hepatitis NN cord-273555-i1d4quos 54 17 C C NNP cord-273555-i1d4quos 54 18 virus virus NN cord-273555-i1d4quos 54 19 IL28B il28b IN cord-273555-i1d4quos 54 20 expression expression NN cord-273555-i1d4quos 54 21 depends depend VBZ cord-273555-i1d4quos 54 22 on on IN cord-273555-i1d4quos 54 23 a a DT cord-273555-i1d4quos 54 24 novel novel JJ cord-273555-i1d4quos 54 25 TT/-G TT/-G NNP cord-273555-i1d4quos 54 26 polymorphism polymorphism NN cord-273555-i1d4quos 54 27 which which WDT cord-273555-i1d4quos 54 28 improves improve VBZ cord-273555-i1d4quos 54 29 HCV HCV NNP cord-273555-i1d4quos 54 30 clearance clearance NN cord-273555-i1d4quos 54 31 prediction prediction NN cord-273555-i1d4quos 54 32 Interferon Interferon NNP cord-273555-i1d4quos 54 33 lambda lambda NN cord-273555-i1d4quos 54 34 4 4 CD cord-273555-i1d4quos 54 35 signals signal NNS cord-273555-i1d4quos 54 36 via via IN cord-273555-i1d4quos 54 37 the the DT cord-273555-i1d4quos 54 38 IFNk IFNk NNS cord-273555-i1d4quos 54 39 receptor receptor NN cord-273555-i1d4quos 54 40 to to TO cord-273555-i1d4quos 54 41 regulate regulate VB cord-273555-i1d4quos 54 42 antiviral antiviral JJ cord-273555-i1d4quos 54 43 activity activity NN cord-273555-i1d4quos 54 44 against against IN cord-273555-i1d4quos 54 45 HCV HCV NNP cord-273555-i1d4quos 54 46 and and CC cord-273555-i1d4quos 54 47 coronaviruses coronaviruse NNS cord-273555-i1d4quos 54 48 Blockade Blockade NNP cord-273555-i1d4quos 54 49 of of IN cord-273555-i1d4quos 54 50 chronic chronic JJ cord-273555-i1d4quos 54 51 type type NN cord-273555-i1d4quos 55 1 I -PRON- PRP cord-273555-i1d4quos 55 2 interferon interferon RB cord-273555-i1d4quos 55 3 signaling signal VBG cord-273555-i1d4quos 55 4 to to TO cord-273555-i1d4quos 55 5 control control VB cord-273555-i1d4quos 55 6 persistent persistent JJ cord-273555-i1d4quos 55 7 LCMV LCMV NNP cord-273555-i1d4quos 55 8 infection infection NN cord-273555-i1d4quos 55 9 Letter Letter NNP cord-273555-i1d4quos 55 10 : : : cord-273555-i1d4quos 55 11 does do VBZ cord-273555-i1d4quos 55 12 the the DT cord-273555-i1d4quos 55 13 IFNL4 IFNL4 NNP cord-273555-i1d4quos 55 14 gene gene NN cord-273555-i1d4quos 55 15 discovery discovery NN cord-273555-i1d4quos 55 16 really really RB cord-273555-i1d4quos 55 17 provide provide VBP cord-273555-i1d4quos 55 18 a a DT cord-273555-i1d4quos 55 19 causal causal JJ cord-273555-i1d4quos 55 20 role role NN cord-273555-i1d4quos 55 21 for for IN cord-273555-i1d4quos 55 22 the the DT cord-273555-i1d4quos 55 23 IL28B IL28B NNP cord-273555-i1d4quos 55 24 haplotype haplotype NN cord-273555-i1d4quos 55 25 blocks block VBZ cord-273555-i1d4quos 55 26 Polymorphism Polymorphism NNP cord-273555-i1d4quos 55 27 of of IN cord-273555-i1d4quos 55 28 interferon interferon NN cord-273555-i1d4quos 55 29 - - HYPH cord-273555-i1d4quos 55 30 k k NN cord-273555-i1d4quos 56 1 and and CC cord-273555-i1d4quos 56 2 IL28B il28b NN cord-273555-i1d4quos 56 3 -effects -effects . cord-273555-i1d4quos 57 1 on on IN cord-273555-i1d4quos 57 2 treatment treatment NN cord-273555-i1d4quos 57 3 response response NN cord-273555-i1d4quos 57 4 to to IN cord-273555-i1d4quos 57 5 interferon interferon NN cord-273555-i1d4quos 58 1 /ribavirin /ribavirin , cord-273555-i1d4quos 58 2 in in IN cord-273555-i1d4quos 58 3 patients patient NNS cord-273555-i1d4quos 58 4 with with IN cord-273555-i1d4quos 58 5 chronic chronic JJ cord-273555-i1d4quos 58 6 hepatitis hepatitis NN cord-273555-i1d4quos 58 7 C c NN cord-273555-i1d4quos 59 1 Interferon interferon NN cord-273555-i1d4quos 59 2 lambda lambda NN cord-273555-i1d4quos 59 3 4 4 CD cord-273555-i1d4quos 59 4 signals signal NNS cord-273555-i1d4quos 59 5 via via IN cord-273555-i1d4quos 59 6 the the DT cord-273555-i1d4quos 59 7 IFNk IFNk NNS cord-273555-i1d4quos 59 8 receptor receptor NN cord-273555-i1d4quos 59 9 to to TO cord-273555-i1d4quos 59 10 regulate regulate VB cord-273555-i1d4quos 59 11 antiviral antiviral JJ cord-273555-i1d4quos 59 12 activity activity NN cord-273555-i1d4quos 59 13 against against IN cord-273555-i1d4quos 59 14 HCV HCV NNP cord-273555-i1d4quos 59 15 and and CC cord-273555-i1d4quos 59 16 coronaviruses coronaviruse NNS cord-273555-i1d4quos 59 17 Hepatic Hepatic NNP cord-273555-i1d4quos 59 18 ISG ISG NNP cord-273555-i1d4quos 59 19 expression expression NN cord-273555-i1d4quos 59 20 is be VBZ cord-273555-i1d4quos 59 21 associated associate VBN cord-273555-i1d4quos 59 22 with with IN cord-273555-i1d4quos 59 23 genetic genetic JJ cord-273555-i1d4quos 59 24 variation variation NN cord-273555-i1d4quos 59 25 in in IN cord-273555-i1d4quos 59 26 interleukin interleukin NN cord-273555-i1d4quos 59 27 28B 28b NN cord-273555-i1d4quos 59 28 and and CC cord-273555-i1d4quos 59 29 the the DT cord-273555-i1d4quos 59 30 outcome outcome NN cord-273555-i1d4quos 59 31 of of IN cord-273555-i1d4quos 59 32 IFN IFN NNP cord-273555-i1d4quos 59 33 therapy therapy NN cord-273555-i1d4quos 59 34 for for IN cord-273555-i1d4quos 59 35 chronic chronic JJ cord-273555-i1d4quos 59 36 hepatitis hepatitis NN cord-273555-i1d4quos 59 37 C C NNP cord-273555-i1d4quos 59 38 A A NNP cord-273555-i1d4quos 59 39 variant variant NN cord-273555-i1d4quos 59 40 upstream upstream NN cord-273555-i1d4quos 59 41 of of IN cord-273555-i1d4quos 59 42 IFNL3 ifnl3 XX cord-273555-i1d4quos 60 1 ( ( -LRB- cord-273555-i1d4quos 60 2 IL28B il28b NN cord-273555-i1d4quos 60 3 ) ) -RRB- cord-273555-i1d4quos 60 4 creating create VBG cord-273555-i1d4quos 60 5 a a DT cord-273555-i1d4quos 60 6 new new JJ cord-273555-i1d4quos 60 7 interferon interferon NN cord-273555-i1d4quos 60 8 gene gene NN cord-273555-i1d4quos 60 9 IFNL4 IFNL4 NNP cord-273555-i1d4quos 60 10 is be VBZ cord-273555-i1d4quos 60 11 associated associate VBN cord-273555-i1d4quos 60 12 with with IN cord-273555-i1d4quos 60 13 impaired impaired JJ cord-273555-i1d4quos 60 14 clearance clearance NN cord-273555-i1d4quos 60 15 of of IN cord-273555-i1d4quos 60 16 hepatitis hepatitis NN cord-273555-i1d4quos 60 17 C C NNP cord-273555-i1d4quos 60 18 virus virus NN cord-273555-i1d4quos 60 19 IL28 IL28 NNP cord-273555-i1d4quos 60 20 variation variation NN cord-273555-i1d4quos 60 21 affects affect VBZ cord-273555-i1d4quos 60 22 expression expression NN cord-273555-i1d4quos 60 23 of of IN cord-273555-i1d4quos 60 24 interferon interferon NN cord-273555-i1d4quos 60 25 stimulated stimulate VBN cord-273555-i1d4quos 60 26 genes gene NNS cord-273555-i1d4quos 60 27 and and CC cord-273555-i1d4quos 60 28 peg peg NN cord-273555-i1d4quos 60 29 - - HYPH cord-273555-i1d4quos 60 30 interferon interferon NN cord-273555-i1d4quos 60 31 and and CC cord-273555-i1d4quos 60 32 ribavirin ribavirin NNP cord-273555-i1d4quos 60 33 therapy therapy NNP cord-273555-i1d4quos 60 34 Letter Letter NNP cord-273555-i1d4quos 60 35 : : : cord-273555-i1d4quos 60 36 the the DT cord-273555-i1d4quos 60 37 irony irony NN cord-273555-i1d4quos 60 38 of of IN cord-273555-i1d4quos 60 39 oral oral JJ cord-273555-i1d4quos 60 40 iron iron NN cord-273555-i1d4quos 60 41 -not -not : cord-273555-i1d4quos 60 42 an an DT cord-273555-i1d4quos 60 43 underdog underdog NN cord-273555-i1d4quos 60 44 for for IN cord-273555-i1d4quos 60 45 post post JJ cord-273555-i1d4quos 60 46 - - JJ cord-273555-i1d4quos 60 47 gastrointestinal gastrointestinal JJ cord-273555-i1d4quos 60 48 bleeding bleed VBG cord-273555-i1d4quos 60 49 anaemia anaemia NN cord-273555-i1d4quos 60 50 ACKNOWLEDGEMENT ACKNOWLEDGEMENT NNP cord-273555-i1d4quos 60 51 Declaration Declaration NNP cord-273555-i1d4quos 60 52 of of IN cord-273555-i1d4quos 60 53 personal personal JJ cord-273555-i1d4quos 60 54 and and CC cord-273555-i1d4quos 60 55 funding funding NN cord-273555-i1d4quos 60 56 interests interest NNS cord-273555-i1d4quos 60 57 : : : cord-273555-i1d4quos 60 58 None none NN cord-273555-i1d4quos 60 59 . . .