id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267867-q52nvn0n	Chevalier, Christophe	Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs	2016-12-14		.txt	text/plain	8001	395	48	Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. We sought to determine whether the siRNAs si240-1a, si244, and si313, shown to be the most efficient in inhibiting the replication of HCV subgenomic replicons both transiently and under selective pressure, are also capable of efficiently blocking virus infection in cell culture.	./cache/cord-267867-q52nvn0n.txt	./txt/cord-267867-q52nvn0n.txt