id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009263-w8bmmgtj	Colpitts, Che C.	Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process	2020-03-18		.txt	text/plain	7111	385	41	The initial binding step primarily involving the lipoprotein component of LVPs likely is a rather unspecific event, which results in the concentration of the virus at the basolateral membrane of hepatocytes and exposure of viral envelope glycoprotein domains that enable the virus to specifically interact with SR-BI, CD81, and CLDN1 (post-binding). Initial attachment of LVPs to hepatocyte basolateral membranes likely involves virus-associated lipoprotein components (particularly apoE [9,13,30-35]), and virus envelope glycoproteins, which interact with highly sulfated heparan sulfate proteoglycans (HSPG) [36] [37] [38] (particularly syndecans [39] [40] [41] ), LDL receptor (LDLR) [42] [43] [44] [45] and SR-BI [46] [47] [48] [49] [50] [51] on the cell surface ( Figure 1 ). Initial attachment of LVPs to hepatocyte basolateral membranes likely involves virus-associated lipoprotein components (particularly apoE [9,13,30-35]), and virus envelope glycoproteins, which interact with highly sulfated heparan sulfate proteoglycans (HSPG) [36] [37] [38] (particularly syndecans [39] [40] [41] ), LDL receptor (LDLR) [42] [43] [44] [45] and SR-BI [46] [47] [48] [49] [50] [51] on the cell surface ( Figure 1 ).	./cache/cord-009263-w8bmmgtj.txt	./txt/cord-009263-w8bmmgtj.txt