id sid tid token lemma pos cord-275041-fcdwitxy 1 1 key key JJ cord-275041-fcdwitxy 1 2 : : : cord-275041-fcdwitxy 1 3 cord-275041-fcdwitxy cord-275041-fcdwitxy NNP cord-275041-fcdwitxy 2 1 authors author NNS cord-275041-fcdwitxy 2 2 : : : cord-275041-fcdwitxy 2 3 Ayerbe Ayerbe NNP cord-275041-fcdwitxy 2 4 , , , cord-275041-fcdwitxy 2 5 Luis Luis NNP cord-275041-fcdwitxy 2 6 ; ; : cord-275041-fcdwitxy 2 7 Risco Risco NNP cord-275041-fcdwitxy 2 8 - - HYPH cord-275041-fcdwitxy 2 9 Risco Risco NNP cord-275041-fcdwitxy 2 10 , , , cord-275041-fcdwitxy 2 11 Carlos Carlos NNP cord-275041-fcdwitxy 2 12 ; ; : cord-275041-fcdwitxy 2 13 Ayis Ayis NNP cord-275041-fcdwitxy 2 14 , , , cord-275041-fcdwitxy 2 15 Salma Salma NNP cord-275041-fcdwitxy 2 16 title title NN cord-275041-fcdwitxy 2 17 : : : cord-275041-fcdwitxy 3 1 The the DT cord-275041-fcdwitxy 3 2 association association NN cord-275041-fcdwitxy 3 3 of of IN cord-275041-fcdwitxy 3 4 treatment treatment NN cord-275041-fcdwitxy 3 5 with with IN cord-275041-fcdwitxy 3 6 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 3 7 and and CC cord-275041-fcdwitxy 3 8 hospital hospital NN cord-275041-fcdwitxy 3 9 mortality mortality NN cord-275041-fcdwitxy 3 10 in in IN cord-275041-fcdwitxy 3 11 COVID-19 covid-19 JJ cord-275041-fcdwitxy 3 12 patients patient NNS cord-275041-fcdwitxy 3 13 date date NN cord-275041-fcdwitxy 3 14 : : : cord-275041-fcdwitxy 3 15 2020 2020 CD cord-275041-fcdwitxy 3 16 - - HYPH cord-275041-fcdwitxy 3 17 09 09 CD cord-275041-fcdwitxy 3 18 - - SYM cord-275041-fcdwitxy 3 19 30 30 CD cord-275041-fcdwitxy 3 20 journal journal NN cord-275041-fcdwitxy 3 21 : : : cord-275041-fcdwitxy 3 22 Intern Intern NNP cord-275041-fcdwitxy 3 23 Emerg Emerg NNP cord-275041-fcdwitxy 3 24 Med Med NNP cord-275041-fcdwitxy 3 25 DOI doi NN cord-275041-fcdwitxy 3 26 : : : cord-275041-fcdwitxy 4 1 10.1007 10.1007 CD cord-275041-fcdwitxy 4 2 / / SYM cord-275041-fcdwitxy 4 3 s11739 s11739 CD cord-275041-fcdwitxy 4 4 - - HYPH cord-275041-fcdwitxy 4 5 020 020 CD cord-275041-fcdwitxy 4 6 - - HYPH cord-275041-fcdwitxy 4 7 02505-x 02505-x CD cord-275041-fcdwitxy 4 8 sha sha NNP cord-275041-fcdwitxy 4 9 : : : cord-275041-fcdwitxy 5 1 b6b20213545c070c391312c7a4a1e516fc1c6d8a b6b20213545c070c391312c7a4a1e516fc1c6d8a NNP cord-275041-fcdwitxy 5 2 doc_id doc_id NNP cord-275041-fcdwitxy 5 3 : : : cord-275041-fcdwitxy 6 1 275041 275041 CD cord-275041-fcdwitxy 6 2 cord_uid cord_uid NNS cord-275041-fcdwitxy 6 3 : : : cord-275041-fcdwitxy 6 4 fcdwitxy fcdwitxy NNP cord-275041-fcdwitxy 7 1 This this DT cord-275041-fcdwitxy 7 2 study study NN cord-275041-fcdwitxy 7 3 investigates investigate VBZ cord-275041-fcdwitxy 7 4 the the DT cord-275041-fcdwitxy 7 5 association association NN cord-275041-fcdwitxy 7 6 between between IN cord-275041-fcdwitxy 7 7 the the DT cord-275041-fcdwitxy 7 8 treatment treatment NN cord-275041-fcdwitxy 7 9 with with IN cord-275041-fcdwitxy 7 10 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 7 11 and and CC cord-275041-fcdwitxy 7 12 mortality mortality NN cord-275041-fcdwitxy 7 13 in in IN cord-275041-fcdwitxy 7 14 patients patient NNS cord-275041-fcdwitxy 7 15 admitted admit VBN cord-275041-fcdwitxy 7 16 with with IN cord-275041-fcdwitxy 7 17 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 7 18 . . . cord-275041-fcdwitxy 8 1 Routinely routinely RB cord-275041-fcdwitxy 8 2 recorded record VBN cord-275041-fcdwitxy 8 3 , , , cord-275041-fcdwitxy 8 4 clinical clinical JJ cord-275041-fcdwitxy 8 5 data datum NNS cord-275041-fcdwitxy 8 6 , , , cord-275041-fcdwitxy 8 7 up up IN cord-275041-fcdwitxy 8 8 to to IN cord-275041-fcdwitxy 8 9 the the DT cord-275041-fcdwitxy 8 10 24th 24th NN cord-275041-fcdwitxy 8 11 of of IN cord-275041-fcdwitxy 8 12 April April NNP cord-275041-fcdwitxy 8 13 2020 2020 CD cord-275041-fcdwitxy 8 14 , , , cord-275041-fcdwitxy 8 15 from from IN cord-275041-fcdwitxy 8 16 the the DT cord-275041-fcdwitxy 8 17 2075 2075 CD cord-275041-fcdwitxy 8 18 patients patient NNS cord-275041-fcdwitxy 8 19 with with IN cord-275041-fcdwitxy 8 20 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 8 21 , , , cord-275041-fcdwitxy 8 22 admitted admit VBN cord-275041-fcdwitxy 8 23 in in IN cord-275041-fcdwitxy 8 24 17 17 CD cord-275041-fcdwitxy 8 25 hospitals hospital NNS cord-275041-fcdwitxy 8 26 in in IN cord-275041-fcdwitxy 8 27 Spain Spain NNP cord-275041-fcdwitxy 8 28 between between IN cord-275041-fcdwitxy 8 29 the the DT cord-275041-fcdwitxy 8 30 1st 1st NN cord-275041-fcdwitxy 8 31 of of IN cord-275041-fcdwitxy 8 32 March March NNP cord-275041-fcdwitxy 8 33 and and CC cord-275041-fcdwitxy 8 34 the the DT cord-275041-fcdwitxy 8 35 20th 20th NN cord-275041-fcdwitxy 8 36 of of IN cord-275041-fcdwitxy 8 37 April April NNP cord-275041-fcdwitxy 8 38 2020 2020 CD cord-275041-fcdwitxy 8 39 were be VBD cord-275041-fcdwitxy 8 40 used use VBN cord-275041-fcdwitxy 8 41 . . . cord-275041-fcdwitxy 9 1 The the DT cord-275041-fcdwitxy 9 2 following follow VBG cord-275041-fcdwitxy 9 3 variables variable NNS cord-275041-fcdwitxy 9 4 were be VBD cord-275041-fcdwitxy 9 5 extracted extract VBN cord-275041-fcdwitxy 9 6 for for IN cord-275041-fcdwitxy 9 7 this this DT cord-275041-fcdwitxy 9 8 study study NN cord-275041-fcdwitxy 9 9 : : : cord-275041-fcdwitxy 9 10 age age NN cord-275041-fcdwitxy 9 11 , , , cord-275041-fcdwitxy 9 12 gender gender NN cord-275041-fcdwitxy 9 13 , , , cord-275041-fcdwitxy 9 14 temperature temperature NN cord-275041-fcdwitxy 9 15 , , , cord-275041-fcdwitxy 9 16 and and CC cord-275041-fcdwitxy 9 17 saturation saturation NN cord-275041-fcdwitxy 9 18 of of IN cord-275041-fcdwitxy 9 19 oxygen oxygen NN cord-275041-fcdwitxy 9 20 on on IN cord-275041-fcdwitxy 9 21 admission admission NN cord-275041-fcdwitxy 9 22 , , , cord-275041-fcdwitxy 9 23 treatment treatment NN cord-275041-fcdwitxy 9 24 with with IN cord-275041-fcdwitxy 9 25 hydroxychloroquine hydroxychloroquine NNP cord-275041-fcdwitxy 9 26 , , , cord-275041-fcdwitxy 9 27 azithromycin azithromycin NNP cord-275041-fcdwitxy 9 28 , , , cord-275041-fcdwitxy 9 29 heparin heparin NN cord-275041-fcdwitxy 9 30 , , , cord-275041-fcdwitxy 9 31 steroids steroid NNS cord-275041-fcdwitxy 9 32 , , , cord-275041-fcdwitxy 9 33 tocilizumab tocilizumab NNP cord-275041-fcdwitxy 9 34 , , , cord-275041-fcdwitxy 9 35 a a DT cord-275041-fcdwitxy 9 36 combination combination NN cord-275041-fcdwitxy 9 37 of of IN cord-275041-fcdwitxy 9 38 lopinavir lopinavir NNS cord-275041-fcdwitxy 9 39 with with IN cord-275041-fcdwitxy 9 40 ritonavir ritonavir NNP cord-275041-fcdwitxy 9 41 , , , cord-275041-fcdwitxy 9 42 and and CC cord-275041-fcdwitxy 9 43 oseltamivir oseltamivir FW cord-275041-fcdwitxy 9 44 , , , cord-275041-fcdwitxy 9 45 together together RB cord-275041-fcdwitxy 9 46 with with IN cord-275041-fcdwitxy 9 47 data datum NNS cord-275041-fcdwitxy 9 48 on on IN cord-275041-fcdwitxy 9 49 mortality mortality NN cord-275041-fcdwitxy 9 50 . . . cord-275041-fcdwitxy 10 1 Multivariable multivariable JJ cord-275041-fcdwitxy 10 2 logistic logistic JJ cord-275041-fcdwitxy 10 3 regression regression NN cord-275041-fcdwitxy 10 4 models model NNS cord-275041-fcdwitxy 10 5 were be VBD cord-275041-fcdwitxy 10 6 used use VBN cord-275041-fcdwitxy 10 7 to to TO cord-275041-fcdwitxy 10 8 investigate investigate VB cord-275041-fcdwitxy 10 9 the the DT cord-275041-fcdwitxy 10 10 associations association NNS cord-275041-fcdwitxy 10 11 . . . cord-275041-fcdwitxy 11 1 At at IN cord-275041-fcdwitxy 11 2 the the DT cord-275041-fcdwitxy 11 3 time time NN cord-275041-fcdwitxy 11 4 of of IN cord-275041-fcdwitxy 11 5 collecting collect VBG cord-275041-fcdwitxy 11 6 the the DT cord-275041-fcdwitxy 11 7 data datum NNS cord-275041-fcdwitxy 11 8 , , , cord-275041-fcdwitxy 11 9 301 301 CD cord-275041-fcdwitxy 11 10 patients patient NNS cord-275041-fcdwitxy 11 11 had have VBD cord-275041-fcdwitxy 11 12 died die VBN cord-275041-fcdwitxy 11 13 , , , cord-275041-fcdwitxy 11 14 1449 1449 CD cord-275041-fcdwitxy 11 15 had have VBD cord-275041-fcdwitxy 11 16 been be VBN cord-275041-fcdwitxy 11 17 discharged discharge VBN cord-275041-fcdwitxy 11 18 home home RB cord-275041-fcdwitxy 11 19 from from IN cord-275041-fcdwitxy 11 20 the the DT cord-275041-fcdwitxy 11 21 hospitals hospital NNS cord-275041-fcdwitxy 11 22 , , , cord-275041-fcdwitxy 11 23 240 240 CD cord-275041-fcdwitxy 11 24 were be VBD cord-275041-fcdwitxy 11 25 still still RB cord-275041-fcdwitxy 11 26 admitted admit VBN cord-275041-fcdwitxy 11 27 , , , cord-275041-fcdwitxy 11 28 and and CC cord-275041-fcdwitxy 11 29 85 85 CD cord-275041-fcdwitxy 11 30 had have VBD cord-275041-fcdwitxy 11 31 been be VBN cord-275041-fcdwitxy 11 32 transferred transfer VBN cord-275041-fcdwitxy 11 33 to to IN cord-275041-fcdwitxy 11 34 hospitals hospital NNS cord-275041-fcdwitxy 11 35 not not RB cord-275041-fcdwitxy 11 36 included include VBN cord-275041-fcdwitxy 11 37 in in IN cord-275041-fcdwitxy 11 38 the the DT cord-275041-fcdwitxy 11 39 study study NN cord-275041-fcdwitxy 11 40 . . . cord-275041-fcdwitxy 12 1 Median median JJ cord-275041-fcdwitxy 12 2 follow follow NN cord-275041-fcdwitxy 12 3 - - HYPH cord-275041-fcdwitxy 12 4 up up RP cord-275041-fcdwitxy 12 5 time time NN cord-275041-fcdwitxy 12 6 was be VBD cord-275041-fcdwitxy 12 7 8 8 CD cord-275041-fcdwitxy 12 8 ( ( -LRB- cord-275041-fcdwitxy 12 9 IQR IQR NNP cord-275041-fcdwitxy 12 10 5–12 5–12 NNP cord-275041-fcdwitxy 12 11 ) ) -RRB- cord-275041-fcdwitxy 12 12 days day NNS cord-275041-fcdwitxy 12 13 . . . cord-275041-fcdwitxy 13 1 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 13 2 had have VBD cord-275041-fcdwitxy 13 3 been be VBN cord-275041-fcdwitxy 13 4 used use VBN cord-275041-fcdwitxy 13 5 in in IN cord-275041-fcdwitxy 13 6 1857 1857 CD cord-275041-fcdwitxy 13 7 patients patient NNS cord-275041-fcdwitxy 13 8 . . . cord-275041-fcdwitxy 14 1 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 14 2 was be VBD cord-275041-fcdwitxy 14 3 associated associate VBN cord-275041-fcdwitxy 14 4 with with IN cord-275041-fcdwitxy 14 5 lower low JJR cord-275041-fcdwitxy 14 6 mortality mortality NN cord-275041-fcdwitxy 14 7 when when WRB cord-275041-fcdwitxy 14 8 the the DT cord-275041-fcdwitxy 14 9 model model NN cord-275041-fcdwitxy 14 10 was be VBD cord-275041-fcdwitxy 14 11 adjusted adjust VBN cord-275041-fcdwitxy 14 12 for for IN cord-275041-fcdwitxy 14 13 age age NN cord-275041-fcdwitxy 14 14 and and CC cord-275041-fcdwitxy 14 15 gender gender NN cord-275041-fcdwitxy 14 16 , , , cord-275041-fcdwitxy 14 17 with with IN cord-275041-fcdwitxy 14 18 OR or CC cord-275041-fcdwitxy 14 19 ( ( -LRB- cord-275041-fcdwitxy 14 20 95 95 CD cord-275041-fcdwitxy 14 21 % % NN cord-275041-fcdwitxy 14 22 CI CI NNP cord-275041-fcdwitxy 14 23 ) ) -RRB- cord-275041-fcdwitxy 14 24 : : : cord-275041-fcdwitxy 14 25 0.44 0.44 CD cord-275041-fcdwitxy 14 26 ( ( -LRB- cord-275041-fcdwitxy 14 27 0.29–0.67 0.29–0.67 NNP cord-275041-fcdwitxy 14 28 ) ) -RRB- cord-275041-fcdwitxy 14 29 . . . cord-275041-fcdwitxy 15 1 This this DT cord-275041-fcdwitxy 15 2 association association NN cord-275041-fcdwitxy 15 3 remained remain VBD cord-275041-fcdwitxy 15 4 significant significant JJ cord-275041-fcdwitxy 15 5 when when WRB cord-275041-fcdwitxy 15 6 saturation saturation NN cord-275041-fcdwitxy 15 7 of of IN cord-275041-fcdwitxy 15 8 oxygen oxygen NN cord-275041-fcdwitxy 15 9 < < XX cord-275041-fcdwitxy 15 10 90 90 CD cord-275041-fcdwitxy 15 11 % % NN cord-275041-fcdwitxy 15 12 and and CC cord-275041-fcdwitxy 15 13 temperature temperature NN cord-275041-fcdwitxy 15 14 > > XX cord-275041-fcdwitxy 15 15 37 37 CD cord-275041-fcdwitxy 15 16 ° ° NN cord-275041-fcdwitxy 15 17 C C NNP cord-275041-fcdwitxy 15 18 were be VBD cord-275041-fcdwitxy 15 19 added add VBN cord-275041-fcdwitxy 15 20 to to IN cord-275041-fcdwitxy 15 21 de de NNP cord-275041-fcdwitxy 15 22 model model NN cord-275041-fcdwitxy 15 23 with with IN cord-275041-fcdwitxy 15 24 OR or CC cord-275041-fcdwitxy 15 25 0.45 0.45 CD cord-275041-fcdwitxy 15 26 ( ( -LRB- cord-275041-fcdwitxy 15 27 0.30–0.68 0.30–0.68 CD cord-275041-fcdwitxy 15 28 ) ) -RRB- cord-275041-fcdwitxy 16 1 p p NN cord-275041-fcdwitxy 16 2 < < XX cord-275041-fcdwitxy 16 3 0.001 0.001 CD cord-275041-fcdwitxy 16 4 , , , cord-275041-fcdwitxy 16 5 and and CC cord-275041-fcdwitxy 16 6 also also RB cord-275041-fcdwitxy 17 1 when when WRB cord-275041-fcdwitxy 17 2 all all PDT cord-275041-fcdwitxy 17 3 the the DT cord-275041-fcdwitxy 17 4 other other JJ cord-275041-fcdwitxy 17 5 drugs drug NNS cord-275041-fcdwitxy 17 6 , , , cord-275041-fcdwitxy 17 7 and and CC cord-275041-fcdwitxy 17 8 time time NN cord-275041-fcdwitxy 17 9 of of IN cord-275041-fcdwitxy 17 10 admission admission NN cord-275041-fcdwitxy 17 11 , , , cord-275041-fcdwitxy 17 12 were be VBD cord-275041-fcdwitxy 17 13 included include VBN cord-275041-fcdwitxy 17 14 as as IN cord-275041-fcdwitxy 17 15 covariates covariate NNS cord-275041-fcdwitxy 17 16 . . . cord-275041-fcdwitxy 18 1 The the DT cord-275041-fcdwitxy 18 2 association association NN cord-275041-fcdwitxy 18 3 between between IN cord-275041-fcdwitxy 18 4 hydroxychloroquine hydroxychloroquine NNP cord-275041-fcdwitxy 18 5 and and CC cord-275041-fcdwitxy 18 6 lower low JJR cord-275041-fcdwitxy 18 7 mortality mortality NN cord-275041-fcdwitxy 18 8 observed observe VBN cord-275041-fcdwitxy 18 9 in in IN cord-275041-fcdwitxy 18 10 this this DT cord-275041-fcdwitxy 18 11 study study NN cord-275041-fcdwitxy 18 12 can can MD cord-275041-fcdwitxy 18 13 be be VB cord-275041-fcdwitxy 18 14 acknowledged acknowledge VBN cord-275041-fcdwitxy 18 15 by by IN cord-275041-fcdwitxy 18 16 clinicians clinician NNS cord-275041-fcdwitxy 18 17 in in IN cord-275041-fcdwitxy 18 18 hospitals hospital NNS cord-275041-fcdwitxy 18 19 and and CC cord-275041-fcdwitxy 18 20 in in IN cord-275041-fcdwitxy 18 21 the the DT cord-275041-fcdwitxy 18 22 community community NN cord-275041-fcdwitxy 18 23 . . . cord-275041-fcdwitxy 19 1 Randomized randomize VBN cord-275041-fcdwitxy 19 2 - - HYPH cord-275041-fcdwitxy 19 3 controlled control VBN cord-275041-fcdwitxy 19 4 trials trial NNS cord-275041-fcdwitxy 19 5 to to TO cord-275041-fcdwitxy 19 6 assess assess VB cord-275041-fcdwitxy 19 7 the the DT cord-275041-fcdwitxy 19 8 causal causal JJ cord-275041-fcdwitxy 19 9 effects effect NNS cord-275041-fcdwitxy 19 10 of of IN cord-275041-fcdwitxy 19 11 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 19 12 in in IN cord-275041-fcdwitxy 19 13 different different JJ cord-275041-fcdwitxy 19 14 therapeutic therapeutic JJ cord-275041-fcdwitxy 19 15 regimes regime NNS cord-275041-fcdwitxy 19 16 are be VBP cord-275041-fcdwitxy 19 17 required require VBN cord-275041-fcdwitxy 19 18 . . . cord-275041-fcdwitxy 20 1 In in IN cord-275041-fcdwitxy 20 2 December December NNP cord-275041-fcdwitxy 20 3 2019 2019 CD cord-275041-fcdwitxy 20 4 , , , cord-275041-fcdwitxy 20 5 an an DT cord-275041-fcdwitxy 20 6 outbreak outbreak NN cord-275041-fcdwitxy 20 7 of of IN cord-275041-fcdwitxy 20 8 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 20 9 , , , cord-275041-fcdwitxy 20 10 a a DT cord-275041-fcdwitxy 20 11 novel novel JJ cord-275041-fcdwitxy 20 12 disease disease NN cord-275041-fcdwitxy 20 13 caused cause VBN cord-275041-fcdwitxy 20 14 by by IN cord-275041-fcdwitxy 20 15 the the DT cord-275041-fcdwitxy 20 16 virus virus NN cord-275041-fcdwitxy 20 17 SARS SARS NNP cord-275041-fcdwitxy 20 18 - - HYPH cord-275041-fcdwitxy 20 19 CoV-2 CoV-2 NNP cord-275041-fcdwitxy 20 20 , , , cord-275041-fcdwitxy 20 21 was be VBD cord-275041-fcdwitxy 20 22 declared declare VBN cord-275041-fcdwitxy 20 23 in in IN cord-275041-fcdwitxy 20 24 China China NNP cord-275041-fcdwitxy 20 25 . . . cord-275041-fcdwitxy 21 1 In in IN cord-275041-fcdwitxy 21 2 the the DT cord-275041-fcdwitxy 21 3 first first JJ cord-275041-fcdwitxy 21 4 months month NNS cord-275041-fcdwitxy 21 5 of of IN cord-275041-fcdwitxy 21 6 2020 2020 CD cord-275041-fcdwitxy 21 7 , , , cord-275041-fcdwitxy 21 8 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 21 9 spread spread VBN cord-275041-fcdwitxy 21 10 throughout throughout IN cord-275041-fcdwitxy 21 11 the the DT cord-275041-fcdwitxy 21 12 world world NN cord-275041-fcdwitxy 21 13 [ [ -LRB- cord-275041-fcdwitxy 21 14 1 1 CD cord-275041-fcdwitxy 21 15 , , , cord-275041-fcdwitxy 21 16 2 2 CD cord-275041-fcdwitxy 21 17 ] ] -RRB- cord-275041-fcdwitxy 21 18 . . . cord-275041-fcdwitxy 22 1 The the DT cord-275041-fcdwitxy 22 2 number number NN cord-275041-fcdwitxy 22 3 of of IN cord-275041-fcdwitxy 22 4 new new JJ cord-275041-fcdwitxy 22 5 cases case NNS cord-275041-fcdwitxy 22 6 in in IN cord-275041-fcdwitxy 22 7 some some DT cord-275041-fcdwitxy 22 8 areas area NNS cord-275041-fcdwitxy 22 9 of of IN cord-275041-fcdwitxy 22 10 the the DT cord-275041-fcdwitxy 22 11 world world NN cord-275041-fcdwitxy 22 12 is be VBZ cord-275041-fcdwitxy 22 13 currently currently RB cord-275041-fcdwitxy 22 14 declining decline VBG cord-275041-fcdwitxy 22 15 ; ; : cord-275041-fcdwitxy 22 16 however however RB cord-275041-fcdwitxy 22 17 , , , cord-275041-fcdwitxy 22 18 it -PRON- PRP cord-275041-fcdwitxy 22 19 continues continue VBZ cord-275041-fcdwitxy 22 20 to to TO cord-275041-fcdwitxy 22 21 rise rise VB cord-275041-fcdwitxy 22 22 worldwide worldwide RB cord-275041-fcdwitxy 22 23 with with IN cord-275041-fcdwitxy 22 24 many many JJ cord-275041-fcdwitxy 22 25 countries country NNS cord-275041-fcdwitxy 22 26 having have VBG cord-275041-fcdwitxy 22 27 second second JJ cord-275041-fcdwitxy 22 28 outbreaks outbreak NNS cord-275041-fcdwitxy 22 29 [ [ -LRB- cord-275041-fcdwitxy 22 30 3 3 CD cord-275041-fcdwitxy 22 31 ] ] -RRB- cord-275041-fcdwitxy 22 32 . . . cord-275041-fcdwitxy 23 1 It -PRON- PRP cord-275041-fcdwitxy 23 2 has have VBZ cord-275041-fcdwitxy 23 3 been be VBN cord-275041-fcdwitxy 23 4 estimated estimate VBN cord-275041-fcdwitxy 23 5 that that IN cord-275041-fcdwitxy 23 6 80 80 CD cord-275041-fcdwitxy 23 7 % % NN cord-275041-fcdwitxy 23 8 of of IN cord-275041-fcdwitxy 23 9 affected affect VBN cord-275041-fcdwitxy 23 10 patients patient NNS cord-275041-fcdwitxy 23 11 have have VBP cord-275041-fcdwitxy 23 12 mild mild JJ cord-275041-fcdwitxy 23 13 symptoms symptom NNS cord-275041-fcdwitxy 23 14 , , , cord-275041-fcdwitxy 23 15 and and CC cord-275041-fcdwitxy 23 16 in in IN cord-275041-fcdwitxy 23 17 the the DT cord-275041-fcdwitxy 23 18 rest rest NN cord-275041-fcdwitxy 23 19 , , , cord-275041-fcdwitxy 23 20 hospital hospital NN cord-275041-fcdwitxy 23 21 care care NN cord-275041-fcdwitxy 23 22 can can MD cord-275041-fcdwitxy 23 23 be be VB cord-275041-fcdwitxy 23 24 necessary necessary JJ cord-275041-fcdwitxy 23 25 , , , cord-275041-fcdwitxy 23 26 and and CC cord-275041-fcdwitxy 23 27 mortality mortality NN cord-275041-fcdwitxy 23 28 is be VBZ cord-275041-fcdwitxy 23 29 less less JJR cord-275041-fcdwitxy 23 30 than than IN cord-275041-fcdwitxy 23 31 2 2 CD cord-275041-fcdwitxy 23 32 % % NN cord-275041-fcdwitxy 23 33 [ [ -LRB- cord-275041-fcdwitxy 23 34 2 2 CD cord-275041-fcdwitxy 23 35 , , , cord-275041-fcdwitxy 23 36 4 4 CD cord-275041-fcdwitxy 23 37 , , , cord-275041-fcdwitxy 23 38 5 5 CD cord-275041-fcdwitxy 23 39 ] ] -RRB- cord-275041-fcdwitxy 23 40 . . . cord-275041-fcdwitxy 24 1 The the DT cord-275041-fcdwitxy 24 2 large large JJ cord-275041-fcdwitxy 24 3 number number NN cord-275041-fcdwitxy 24 4 of of IN cord-275041-fcdwitxy 24 5 simultaneous simultaneous JJ cord-275041-fcdwitxy 24 6 cases case NNS cord-275041-fcdwitxy 24 7 of of IN cord-275041-fcdwitxy 24 8 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 24 9 has have VBZ cord-275041-fcdwitxy 24 10 overloaded overload VBN cord-275041-fcdwitxy 24 11 hospitals hospital NNS cord-275041-fcdwitxy 24 12 in in IN cord-275041-fcdwitxy 24 13 many many JJ cord-275041-fcdwitxy 24 14 countries country NNS cord-275041-fcdwitxy 24 15 , , , cord-275041-fcdwitxy 24 16 making make VBG cord-275041-fcdwitxy 24 17 it -PRON- PRP cord-275041-fcdwitxy 24 18 very very RB cord-275041-fcdwitxy 24 19 difficult difficult JJ cord-275041-fcdwitxy 24 20 to to TO cord-275041-fcdwitxy 24 21 provide provide VB cord-275041-fcdwitxy 24 22 an an DT cord-275041-fcdwitxy 24 23 adequate adequate JJ cord-275041-fcdwitxy 24 24 care care NN cord-275041-fcdwitxy 24 25 . . . cord-275041-fcdwitxy 25 1 Many many JJ cord-275041-fcdwitxy 25 2 governments government NNS cord-275041-fcdwitxy 25 3 have have VBP cord-275041-fcdwitxy 25 4 used use VBN cord-275041-fcdwitxy 25 5 costly costly JJ cord-275041-fcdwitxy 25 6 and and CC cord-275041-fcdwitxy 25 7 disruptive disruptive JJ cord-275041-fcdwitxy 25 8 policies policy NNS cord-275041-fcdwitxy 25 9 to to TO cord-275041-fcdwitxy 25 10 confine confine VB cord-275041-fcdwitxy 25 11 and and CC cord-275041-fcdwitxy 25 12 distance distance VB cord-275041-fcdwitxy 25 13 the the DT cord-275041-fcdwitxy 25 14 population population NN cord-275041-fcdwitxy 25 15 to to TO cord-275041-fcdwitxy 25 16 reduce reduce VB cord-275041-fcdwitxy 25 17 the the DT cord-275041-fcdwitxy 25 18 transmission transmission NN cord-275041-fcdwitxy 25 19 of of IN cord-275041-fcdwitxy 25 20 the the DT cord-275041-fcdwitxy 25 21 disease disease NN cord-275041-fcdwitxy 25 22 and and CC cord-275041-fcdwitxy 25 23 prevent prevent VB cord-275041-fcdwitxy 25 24 a a DT cord-275041-fcdwitxy 25 25 second second JJ cord-275041-fcdwitxy 25 26 wave wave NN cord-275041-fcdwitxy 25 27 [ [ -LRB- cord-275041-fcdwitxy 25 28 5 5 CD cord-275041-fcdwitxy 25 29 ] ] -RRB- cord-275041-fcdwitxy 25 30 [ [ -LRB- cord-275041-fcdwitxy 25 31 6 6 CD cord-275041-fcdwitxy 25 32 ] ] -RRB- cord-275041-fcdwitxy 25 33 [ [ -LRB- cord-275041-fcdwitxy 25 34 7 7 CD cord-275041-fcdwitxy 25 35 ] ] -RRB- cord-275041-fcdwitxy 25 36 . . . cord-275041-fcdwitxy 26 1 These these DT cord-275041-fcdwitxy 26 2 measures measure NNS cord-275041-fcdwitxy 26 3 will will MD cord-275041-fcdwitxy 26 4 need need VB cord-275041-fcdwitxy 26 5 to to TO cord-275041-fcdwitxy 26 6 be be VB cord-275041-fcdwitxy 26 7 maintained maintain VBN cord-275041-fcdwitxy 26 8 in in IN cord-275041-fcdwitxy 26 9 some some DT cord-275041-fcdwitxy 26 10 manner manner NN cord-275041-fcdwitxy 26 11 until until IN cord-275041-fcdwitxy 26 12 vaccines vaccine NNS cord-275041-fcdwitxy 26 13 or or CC cord-275041-fcdwitxy 26 14 effective effective JJ cord-275041-fcdwitxy 26 15 treatments treatment NNS cord-275041-fcdwitxy 26 16 become become VBP cord-275041-fcdwitxy 26 17 available available JJ cord-275041-fcdwitxy 26 18 to to TO cord-275041-fcdwitxy 26 19 avoid avoid VB cord-275041-fcdwitxy 26 20 the the DT cord-275041-fcdwitxy 26 21 risk risk NN cord-275041-fcdwitxy 26 22 of of IN cord-275041-fcdwitxy 26 23 later later JJ cord-275041-fcdwitxy 26 24 epidemics epidemic NNS cord-275041-fcdwitxy 26 25 [ [ -LRB- cord-275041-fcdwitxy 26 26 5 5 CD cord-275041-fcdwitxy 26 27 , , , cord-275041-fcdwitxy 26 28 8 8 CD cord-275041-fcdwitxy 26 29 ] ] -RRB- cord-275041-fcdwitxy 26 30 . . . cord-275041-fcdwitxy 27 1 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 27 2 is be VBZ cord-275041-fcdwitxy 27 3 negatively negatively RB cord-275041-fcdwitxy 27 4 affecting affect VBG cord-275041-fcdwitxy 27 5 all all DT cord-275041-fcdwitxy 27 6 areas area NNS cord-275041-fcdwitxy 27 7 of of IN cord-275041-fcdwitxy 27 8 healthcare healthcare NN cord-275041-fcdwitxy 27 9 , , , cord-275041-fcdwitxy 27 10 and and CC cord-275041-fcdwitxy 27 11 is be VBZ cord-275041-fcdwitxy 27 12 also also RB cord-275041-fcdwitxy 27 13 having have VBG cord-275041-fcdwitxy 27 14 an an DT cord-275041-fcdwitxy 27 15 adverse adverse JJ cord-275041-fcdwitxy 27 16 impact impact NN cord-275041-fcdwitxy 27 17 on on IN cord-275041-fcdwitxy 27 18 the the DT cord-275041-fcdwitxy 27 19 entire entire JJ cord-275041-fcdwitxy 27 20 society society NN cord-275041-fcdwitxy 27 21 and and CC cord-275041-fcdwitxy 27 22 the the DT cord-275041-fcdwitxy 27 23 international international JJ cord-275041-fcdwitxy 27 24 economy economy NN cord-275041-fcdwitxy 27 25 . . . cord-275041-fcdwitxy 28 1 Using use VBG cord-275041-fcdwitxy 28 2 limited limited JJ cord-275041-fcdwitxy 28 3 evidence evidence NN cord-275041-fcdwitxy 28 4 and and CC cord-275041-fcdwitxy 28 5 clinical clinical JJ cord-275041-fcdwitxy 28 6 experience experience NN cord-275041-fcdwitxy 28 7 , , , cord-275041-fcdwitxy 28 8 doctors doctor NNS cord-275041-fcdwitxy 28 9 have have VBP cord-275041-fcdwitxy 28 10 treated treat VBN cord-275041-fcdwitxy 28 11 COVID-19 covid-19 CD cord-275041-fcdwitxy 28 12 patients patient NNS cord-275041-fcdwitxy 28 13 with with IN cord-275041-fcdwitxy 28 14 different different JJ cord-275041-fcdwitxy 28 15 drugs drug NNS cord-275041-fcdwitxy 28 16 to to TO cord-275041-fcdwitxy 28 17 eliminate eliminate VB cord-275041-fcdwitxy 28 18 or or CC cord-275041-fcdwitxy 28 19 reduce reduce VB cord-275041-fcdwitxy 28 20 the the DT cord-275041-fcdwitxy 28 21 presence presence NN cord-275041-fcdwitxy 28 22 of of IN cord-275041-fcdwitxy 28 23 the the DT cord-275041-fcdwitxy 28 24 virus virus NN cord-275041-fcdwitxy 28 25 , , , cord-275041-fcdwitxy 28 26 including include VBG cord-275041-fcdwitxy 28 27 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 28 28 ( ( -LRB- cord-275041-fcdwitxy 28 29 HCQ HCQ NNP cord-275041-fcdwitxy 28 30 ) ) -RRB- cord-275041-fcdwitxy 28 31 [ [ -LRB- cord-275041-fcdwitxy 28 32 9 9 CD cord-275041-fcdwitxy 28 33 ] ] -RRB- cord-275041-fcdwitxy 28 34 [ [ -LRB- cord-275041-fcdwitxy 28 35 10 10 CD cord-275041-fcdwitxy 28 36 ] ] -RRB- cord-275041-fcdwitxy 28 37 [ [ -LRB- cord-275041-fcdwitxy 28 38 11 11 CD cord-275041-fcdwitxy 28 39 ] ] -RRB- cord-275041-fcdwitxy 28 40 [ [ -LRB- cord-275041-fcdwitxy 28 41 12 12 CD cord-275041-fcdwitxy 28 42 ] ] -RRB- cord-275041-fcdwitxy 28 43 . . . cord-275041-fcdwitxy 29 1 The the DT cord-275041-fcdwitxy 29 2 use use NN cord-275041-fcdwitxy 29 3 of of IN cord-275041-fcdwitxy 29 4 this this DT cord-275041-fcdwitxy 29 5 drug drug NN cord-275041-fcdwitxy 29 6 is be VBZ cord-275041-fcdwitxy 29 7 based base VBN cord-275041-fcdwitxy 29 8 on on IN cord-275041-fcdwitxy 29 9 its -PRON- PRP$ cord-275041-fcdwitxy 29 10 anti anti JJ cord-275041-fcdwitxy 29 11 - - JJ cord-275041-fcdwitxy 29 12 inflammatory inflammatory JJ cord-275041-fcdwitxy 29 13 and and CC cord-275041-fcdwitxy 29 14 antiviral antiviral JJ cord-275041-fcdwitxy 29 15 effect effect NN cord-275041-fcdwitxy 29 16 [ [ -LRB- cord-275041-fcdwitxy 29 17 11 11 CD cord-275041-fcdwitxy 29 18 , , , cord-275041-fcdwitxy 29 19 12 12 CD cord-275041-fcdwitxy 29 20 ] ] -RRB- cord-275041-fcdwitxy 29 21 . . . cord-275041-fcdwitxy 30 1 There there EX cord-275041-fcdwitxy 30 2 are be VBP cord-275041-fcdwitxy 30 3 some some DT cord-275041-fcdwitxy 30 4 in in IN cord-275041-fcdwitxy 30 5 vitro vitro FW cord-275041-fcdwitxy 30 6 data datum NNS cord-275041-fcdwitxy 30 7 supporting support VBG cord-275041-fcdwitxy 30 8 the the DT cord-275041-fcdwitxy 30 9 ability ability NN cord-275041-fcdwitxy 30 10 of of IN cord-275041-fcdwitxy 30 11 HCQ HCQ NNP cord-275041-fcdwitxy 30 12 to to TO cord-275041-fcdwitxy 30 13 inhibit inhibit VB cord-275041-fcdwitxy 30 14 SARS SARS NNP cord-275041-fcdwitxy 30 15 - - HYPH cord-275041-fcdwitxy 30 16 CoV-2 CoV-2 NNP cord-275041-fcdwitxy 30 17 activity activity NN cord-275041-fcdwitxy 30 18 [ [ -LRB- cord-275041-fcdwitxy 30 19 13 13 CD cord-275041-fcdwitxy 30 20 , , , cord-275041-fcdwitxy 30 21 14 14 CD cord-275041-fcdwitxy 30 22 ] ] -RRB- cord-275041-fcdwitxy 30 23 . . . cord-275041-fcdwitxy 31 1 HCQ HCQ NNP cord-275041-fcdwitxy 31 2 may may MD cord-275041-fcdwitxy 31 3 lead lead VB cord-275041-fcdwitxy 31 4 to to IN cord-275041-fcdwitxy 31 5 the the DT cord-275041-fcdwitxy 31 6 clinical clinical JJ cord-275041-fcdwitxy 31 7 improvement improvement NN cord-275041-fcdwitxy 31 8 of of IN cord-275041-fcdwitxy 31 9 the the DT cord-275041-fcdwitxy 31 10 patients patient NNS cord-275041-fcdwitxy 31 11 , , , cord-275041-fcdwitxy 31 12 it -PRON- PRP cord-275041-fcdwitxy 31 13 is be VBZ cord-275041-fcdwitxy 31 14 safe safe JJ cord-275041-fcdwitxy 31 15 , , , cord-275041-fcdwitxy 31 16 economical economical JJ cord-275041-fcdwitxy 31 17 , , , cord-275041-fcdwitxy 31 18 and and CC cord-275041-fcdwitxy 31 19 easy easy JJ cord-275041-fcdwitxy 31 20 to to TO cord-275041-fcdwitxy 31 21 use use VB cord-275041-fcdwitxy 31 22 , , , cord-275041-fcdwitxy 31 23 and and CC cord-275041-fcdwitxy 31 24 it -PRON- PRP cord-275041-fcdwitxy 31 25 can can MD cord-275041-fcdwitxy 31 26 be be VB cord-275041-fcdwitxy 31 27 given give VBN cord-275041-fcdwitxy 31 28 both both DT cord-275041-fcdwitxy 31 29 to to IN cord-275041-fcdwitxy 31 30 admitted admit VBN cord-275041-fcdwitxy 31 31 and and CC cord-275041-fcdwitxy 31 32 outpatients outpatient NNS cord-275041-fcdwitxy 31 33 . . . cord-275041-fcdwitxy 32 1 If if IN cord-275041-fcdwitxy 32 2 the the DT cord-275041-fcdwitxy 32 3 treatment treatment NN cord-275041-fcdwitxy 32 4 with with IN cord-275041-fcdwitxy 32 5 HCQ HCQ NNP cord-275041-fcdwitxy 32 6 is be VBZ cord-275041-fcdwitxy 32 7 confirmed confirm VBN cord-275041-fcdwitxy 32 8 to to TO cord-275041-fcdwitxy 32 9 be be VB cord-275041-fcdwitxy 32 10 effective effective JJ cord-275041-fcdwitxy 32 11 , , , cord-275041-fcdwitxy 32 12 it -PRON- PRP cord-275041-fcdwitxy 32 13 could could MD cord-275041-fcdwitxy 32 14 be be VB cord-275041-fcdwitxy 32 15 used use VBN cord-275041-fcdwitxy 32 16 in in IN cord-275041-fcdwitxy 32 17 the the DT cord-275041-fcdwitxy 32 18 early early JJ cord-275041-fcdwitxy 32 19 stages stage NNS cord-275041-fcdwitxy 32 20 of of IN cord-275041-fcdwitxy 32 21 the the DT cord-275041-fcdwitxy 32 22 disease disease NN cord-275041-fcdwitxy 32 23 , , , cord-275041-fcdwitxy 32 24 and and CC cord-275041-fcdwitxy 32 25 decrease decrease VB cord-275041-fcdwitxy 32 26 the the DT cord-275041-fcdwitxy 32 27 need need NN cord-275041-fcdwitxy 32 28 for for IN cord-275041-fcdwitxy 32 29 admissions admission NNS cord-275041-fcdwitxy 32 30 , , , cord-275041-fcdwitxy 32 31 the the DT cord-275041-fcdwitxy 32 32 mortality mortality NN cord-275041-fcdwitxy 32 33 , , , cord-275041-fcdwitxy 32 34 the the DT cord-275041-fcdwitxy 32 35 transmission transmission NN cord-275041-fcdwitxy 32 36 of of IN cord-275041-fcdwitxy 32 37 the the DT cord-275041-fcdwitxy 32 38 infection infection NN cord-275041-fcdwitxy 32 39 , , , cord-275041-fcdwitxy 32 40 and and CC cord-275041-fcdwitxy 32 41 its -PRON- PRP$ cord-275041-fcdwitxy 32 42 impact impact NN cord-275041-fcdwitxy 32 43 on on IN cord-275041-fcdwitxy 32 44 other other JJ cord-275041-fcdwitxy 32 45 areas area NNS cord-275041-fcdwitxy 32 46 of of IN cord-275041-fcdwitxy 32 47 health health NN cord-275041-fcdwitxy 32 48 care care NN cord-275041-fcdwitxy 32 49 . . . cord-275041-fcdwitxy 33 1 However however RB cord-275041-fcdwitxy 33 2 , , , cord-275041-fcdwitxy 33 3 the the DT cord-275041-fcdwitxy 33 4 use use NN cord-275041-fcdwitxy 33 5 of of IN cord-275041-fcdwitxy 33 6 HCQ HCQ NNP cord-275041-fcdwitxy 33 7 is be VBZ cord-275041-fcdwitxy 33 8 supported support VBN cord-275041-fcdwitxy 33 9 by by IN cord-275041-fcdwitxy 33 10 limited limited JJ cord-275041-fcdwitxy 33 11 evidence evidence NN cord-275041-fcdwitxy 33 12 , , , cord-275041-fcdwitxy 33 13 and and CC cord-275041-fcdwitxy 33 14 it -PRON- PRP cord-275041-fcdwitxy 33 15 may may MD cord-275041-fcdwitxy 33 16 not not RB cord-275041-fcdwitxy 33 17 lead lead VB cord-275041-fcdwitxy 33 18 to to IN cord-275041-fcdwitxy 33 19 any any DT cord-275041-fcdwitxy 33 20 clinical clinical JJ cord-275041-fcdwitxy 33 21 benefit benefit NN cord-275041-fcdwitxy 33 22 . . . cord-275041-fcdwitxy 34 1 Studies study NNS cord-275041-fcdwitxy 34 2 on on IN cord-275041-fcdwitxy 34 3 the the DT cord-275041-fcdwitxy 34 4 clinical clinical JJ cord-275041-fcdwitxy 34 5 outcomes outcome NNS cord-275041-fcdwitxy 34 6 associated associate VBN cord-275041-fcdwitxy 34 7 with with IN cord-275041-fcdwitxy 34 8 HCQ HCQ NNP cord-275041-fcdwitxy 34 9 are be VBP cord-275041-fcdwitxy 34 10 required require VBN cord-275041-fcdwitxy 34 11 . . . cord-275041-fcdwitxy 35 1 Research research NN cord-275041-fcdwitxy 35 2 policies policy NNS cord-275041-fcdwitxy 35 3 are be VBP cord-275041-fcdwitxy 35 4 currently currently RB cord-275041-fcdwitxy 35 5 shifting shift VBG cord-275041-fcdwitxy 35 6 towards towards IN cord-275041-fcdwitxy 35 7 the the DT cord-275041-fcdwitxy 35 8 investigation investigation NN cord-275041-fcdwitxy 35 9 of of IN cord-275041-fcdwitxy 35 10 more more RBR cord-275041-fcdwitxy 35 11 expensive expensive JJ cord-275041-fcdwitxy 35 12 treatments treatment NNS cord-275041-fcdwitxy 35 13 [ [ -LRB- cord-275041-fcdwitxy 35 14 15 15 CD cord-275041-fcdwitxy 35 15 ] ] -RRB- cord-275041-fcdwitxy 35 16 [ [ -LRB- cord-275041-fcdwitxy 35 17 16 16 CD cord-275041-fcdwitxy 35 18 ] ] -RRB- cord-275041-fcdwitxy 35 19 [ [ -LRB- cord-275041-fcdwitxy 35 20 17 17 CD cord-275041-fcdwitxy 35 21 ] ] -RRB- cord-275041-fcdwitxy 35 22 [ [ -LRB- cord-275041-fcdwitxy 35 23 18 18 CD cord-275041-fcdwitxy 35 24 ] ] -RRB- cord-275041-fcdwitxy 35 25 . . . cord-275041-fcdwitxy 36 1 Studies study NNS cord-275041-fcdwitxy 36 2 on on IN cord-275041-fcdwitxy 36 3 HCQ HCQ NNP cord-275041-fcdwitxy 36 4 could could MD cord-275041-fcdwitxy 36 5 inform inform VB cord-275041-fcdwitxy 36 6 evidence evidence NN cord-275041-fcdwitxy 36 7 - - HYPH cord-275041-fcdwitxy 36 8 based base VBN cord-275041-fcdwitxy 36 9 and and CC cord-275041-fcdwitxy 36 10 affordable affordable JJ cord-275041-fcdwitxy 36 11 management management NN cord-275041-fcdwitxy 36 12 for for IN cord-275041-fcdwitxy 36 13 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 36 14 , , , cord-275041-fcdwitxy 36 15 which which WDT cord-275041-fcdwitxy 36 16 may may MD cord-275041-fcdwitxy 36 17 be be VB cord-275041-fcdwitxy 36 18 particularly particularly RB cord-275041-fcdwitxy 36 19 relevant relevant JJ cord-275041-fcdwitxy 36 20 when when WRB cord-275041-fcdwitxy 36 21 the the DT cord-275041-fcdwitxy 36 22 world world NN cord-275041-fcdwitxy 36 23 is be VBZ cord-275041-fcdwitxy 36 24 facing face VBG cord-275041-fcdwitxy 36 25 an an DT cord-275041-fcdwitxy 36 26 economic economic JJ cord-275041-fcdwitxy 36 27 crisis crisis NN cord-275041-fcdwitxy 36 28 , , , cord-275041-fcdwitxy 36 29 more more RBR cord-275041-fcdwitxy 36 30 so so RB cord-275041-fcdwitxy 36 31 in in IN cord-275041-fcdwitxy 36 32 areas area NNS cord-275041-fcdwitxy 36 33 where where WRB cord-275041-fcdwitxy 36 34 health health NN cord-275041-fcdwitxy 36 35 care care NN cord-275041-fcdwitxy 36 36 is be VBZ cord-275041-fcdwitxy 36 37 based base VBN cord-275041-fcdwitxy 36 38 on on IN cord-275041-fcdwitxy 36 39 limited limited JJ cord-275041-fcdwitxy 36 40 resources resource NNS cord-275041-fcdwitxy 36 41 . . . cord-275041-fcdwitxy 37 1 This this DT cord-275041-fcdwitxy 37 2 study study NN cord-275041-fcdwitxy 37 3 investigates investigate VBZ cord-275041-fcdwitxy 37 4 the the DT cord-275041-fcdwitxy 37 5 association association NN cord-275041-fcdwitxy 37 6 between between IN cord-275041-fcdwitxy 37 7 treatment treatment NN cord-275041-fcdwitxy 37 8 with with IN cord-275041-fcdwitxy 37 9 HCQ hcq NN cord-275041-fcdwitxy 37 10 and and CC cord-275041-fcdwitxy 37 11 mortality mortality NN cord-275041-fcdwitxy 37 12 , , , cord-275041-fcdwitxy 37 13 in in IN cord-275041-fcdwitxy 37 14 hospitalized hospitalize VBN cord-275041-fcdwitxy 37 15 patients patient NNS cord-275041-fcdwitxy 37 16 with with IN cord-275041-fcdwitxy 37 17 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 37 18 . . . cord-275041-fcdwitxy 38 1 The the DT cord-275041-fcdwitxy 38 2 clinical clinical JJ cord-275041-fcdwitxy 38 3 records record NNS cord-275041-fcdwitxy 38 4 up up IN cord-275041-fcdwitxy 38 5 to to IN cord-275041-fcdwitxy 38 6 the the DT cord-275041-fcdwitxy 38 7 24th 24th NN cord-275041-fcdwitxy 38 8 of of IN cord-275041-fcdwitxy 38 9 April April NNP cord-275041-fcdwitxy 38 10 2020 2020 CD cord-275041-fcdwitxy 38 11 , , , cord-275041-fcdwitxy 38 12 of of IN cord-275041-fcdwitxy 38 13 all all PDT cord-275041-fcdwitxy 38 14 the the DT cord-275041-fcdwitxy 38 15 patients patient NNS cord-275041-fcdwitxy 38 16 with with IN cord-275041-fcdwitxy 38 17 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 38 18 ( ( -LRB- cord-275041-fcdwitxy 38 19 n n NN cord-275041-fcdwitxy 38 20 = = SYM cord-275041-fcdwitxy 38 21 2075 2075 CD cord-275041-fcdwitxy 38 22 ) ) -RRB- cord-275041-fcdwitxy 38 23 , , , cord-275041-fcdwitxy 38 24 admitted admit VBN cord-275041-fcdwitxy 38 25 in in IN cord-275041-fcdwitxy 38 26 all all DT cord-275041-fcdwitxy 38 27 17 17 CD cord-275041-fcdwitxy 38 28 Spanish spanish JJ cord-275041-fcdwitxy 38 29 hospitals hospital NNS cord-275041-fcdwitxy 38 30 , , , cord-275041-fcdwitxy 38 31 of of IN cord-275041-fcdwitxy 38 32 the the DT cord-275041-fcdwitxy 38 33 private private JJ cord-275041-fcdwitxy 38 34 healthcare healthcare NN cord-275041-fcdwitxy 38 35 provider provider NN cord-275041-fcdwitxy 38 36 HM HM NNP cord-275041-fcdwitxy 38 37 Hospitales Hospitales NNP cord-275041-fcdwitxy 38 38 , , , cord-275041-fcdwitxy 38 39 were be VBD cord-275041-fcdwitxy 38 40 reviewed review VBN cord-275041-fcdwitxy 38 41 . . . cord-275041-fcdwitxy 39 1 These these DT cord-275041-fcdwitxy 39 2 hospitals hospital NNS cord-275041-fcdwitxy 39 3 are be VBP cord-275041-fcdwitxy 39 4 based base VBN cord-275041-fcdwitxy 39 5 in in IN cord-275041-fcdwitxy 39 6 the the DT cord-275041-fcdwitxy 39 7 provinces province NNS cord-275041-fcdwitxy 39 8 of of IN cord-275041-fcdwitxy 39 9 Barcelona Barcelona NNP cord-275041-fcdwitxy 39 10 , , , cord-275041-fcdwitxy 39 11 Coruña Coruña NNP cord-275041-fcdwitxy 39 12 , , , cord-275041-fcdwitxy 39 13 León León NNP cord-275041-fcdwitxy 39 14 , , , cord-275041-fcdwitxy 39 15 Madrid Madrid NNP cord-275041-fcdwitxy 39 16 , , , cord-275041-fcdwitxy 39 17 Pontevedra Pontevedra NNP cord-275041-fcdwitxy 39 18 , , , cord-275041-fcdwitxy 39 19 and and CC cord-275041-fcdwitxy 39 20 Toledo Toledo NNP cord-275041-fcdwitxy 39 21 [ [ -LRB- cord-275041-fcdwitxy 39 22 19 19 CD cord-275041-fcdwitxy 39 23 ] ] -RRB- cord-275041-fcdwitxy 39 24 . . . cord-275041-fcdwitxy 40 1 Patients patient NNS cord-275041-fcdwitxy 40 2 had have VBD cord-275041-fcdwitxy 40 3 been be VBN cord-275041-fcdwitxy 40 4 diagnosed diagnose VBN cord-275041-fcdwitxy 40 5 with with IN cord-275041-fcdwitxy 40 6 polymerase polymerase NN cord-275041-fcdwitxy 40 7 chain chain NN cord-275041-fcdwitxy 40 8 reaction reaction NN cord-275041-fcdwitxy 40 9 test test NN cord-275041-fcdwitxy 40 10 of of IN cord-275041-fcdwitxy 40 11 respiratory respiratory JJ cord-275041-fcdwitxy 40 12 samples sample NNS cord-275041-fcdwitxy 40 13 for for IN cord-275041-fcdwitxy 40 14 SARS SARS NNP cord-275041-fcdwitxy 40 15 - - HYPH cord-275041-fcdwitxy 40 16 CoV-2 CoV-2 NNP cord-275041-fcdwitxy 40 17 , , , cord-275041-fcdwitxy 40 18 between between IN cord-275041-fcdwitxy 40 19 the the DT cord-275041-fcdwitxy 40 20 1st 1st NN cord-275041-fcdwitxy 40 21 of of IN cord-275041-fcdwitxy 40 22 March March NNP cord-275041-fcdwitxy 40 23 and and CC cord-275041-fcdwitxy 40 24 the the DT cord-275041-fcdwitxy 40 25 20th 20th NN cord-275041-fcdwitxy 40 26 of of IN cord-275041-fcdwitxy 40 27 April April NNP cord-275041-fcdwitxy 40 28 2020 2020 CD cord-275041-fcdwitxy 40 29 . . . cord-275041-fcdwitxy 41 1 Seven seven CD cord-275041-fcdwitxy 41 2 patients patient NNS cord-275041-fcdwitxy 41 3 had have VBD cord-275041-fcdwitxy 41 4 been be VBN cord-275041-fcdwitxy 41 5 admitted admit VBN cord-275041-fcdwitxy 41 6 before before IN cord-275041-fcdwitxy 41 7 the the DT cord-275041-fcdwitxy 41 8 1st 1st NN cord-275041-fcdwitxy 41 9 of of IN cord-275041-fcdwitxy 41 10 March March NNP cord-275041-fcdwitxy 41 11 2020 2020 CD cord-275041-fcdwitxy 41 12 . . . cord-275041-fcdwitxy 42 1 Data datum NNS cord-275041-fcdwitxy 42 2 on on IN cord-275041-fcdwitxy 42 3 age age NN cord-275041-fcdwitxy 42 4 and and CC cord-275041-fcdwitxy 42 5 gender gender NN cord-275041-fcdwitxy 42 6 , , , cord-275041-fcdwitxy 42 7 together together RB cord-275041-fcdwitxy 42 8 with with IN cord-275041-fcdwitxy 42 9 temperature temperature NN cord-275041-fcdwitxy 42 10 and and CC cord-275041-fcdwitxy 42 11 saturation saturation NN cord-275041-fcdwitxy 42 12 of of IN cord-275041-fcdwitxy 42 13 oxygen oxygen NN cord-275041-fcdwitxy 42 14 at at IN cord-275041-fcdwitxy 42 15 the the DT cord-275041-fcdwitxy 42 16 time time NN cord-275041-fcdwitxy 42 17 of of IN cord-275041-fcdwitxy 42 18 admission admission NN cord-275041-fcdwitxy 42 19 , , , cord-275041-fcdwitxy 42 20 were be VBD cord-275041-fcdwitxy 42 21 collected collect VBN cord-275041-fcdwitxy 42 22 . . . cord-275041-fcdwitxy 43 1 Data datum NNS cord-275041-fcdwitxy 43 2 on on IN cord-275041-fcdwitxy 43 3 treatments treatment NNS cord-275041-fcdwitxy 43 4 at at IN cord-275041-fcdwitxy 43 5 any any DT cord-275041-fcdwitxy 43 6 time time NN cord-275041-fcdwitxy 43 7 during during IN cord-275041-fcdwitxy 43 8 admission admission NN cord-275041-fcdwitxy 43 9 with with IN cord-275041-fcdwitxy 43 10 HCQ HCQ NNP cord-275041-fcdwitxy 43 11 were be VBD cord-275041-fcdwitxy 43 12 collected collect VBN cord-275041-fcdwitxy 43 13 . . . cord-275041-fcdwitxy 44 1 Once once IN cord-275041-fcdwitxy 44 2 it -PRON- PRP cord-275041-fcdwitxy 44 3 was be VBD cord-275041-fcdwitxy 44 4 approved approve VBN cord-275041-fcdwitxy 44 5 for for IN cord-275041-fcdwitxy 44 6 clinical clinical JJ cord-275041-fcdwitxy 44 7 use use NN cord-275041-fcdwitxy 44 8 in in IN cord-275041-fcdwitxy 44 9 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 44 10 patients patient NNS cord-275041-fcdwitxy 44 11 , , , cord-275041-fcdwitxy 44 12 HCQ HCQ NNP cord-275041-fcdwitxy 44 13 was be VBD cord-275041-fcdwitxy 44 14 started start VBN cord-275041-fcdwitxy 44 15 immediately immediately RB cord-275041-fcdwitxy 44 16 after after IN cord-275041-fcdwitxy 44 17 admission admission NN cord-275041-fcdwitxy 44 18 , , , cord-275041-fcdwitxy 44 19 and and CC cord-275041-fcdwitxy 44 20 it -PRON- PRP cord-275041-fcdwitxy 44 21 was be VBD cord-275041-fcdwitxy 44 22 stopped stop VBN cord-275041-fcdwitxy 44 23 if if IN cord-275041-fcdwitxy 44 24 any any DT cord-275041-fcdwitxy 44 25 abnormalities abnormality NNS cord-275041-fcdwitxy 44 26 were be VBD cord-275041-fcdwitxy 44 27 identified identify VBN cord-275041-fcdwitxy 44 28 in in IN cord-275041-fcdwitxy 44 29 the the DT cord-275041-fcdwitxy 44 30 ECGs ecg NNS cord-275041-fcdwitxy 44 31 that that WDT cord-275041-fcdwitxy 44 32 were be VBD cord-275041-fcdwitxy 44 33 done do VBN cord-275041-fcdwitxy 44 34 on on IN cord-275041-fcdwitxy 44 35 a a DT cord-275041-fcdwitxy 44 36 daily daily JJ cord-275041-fcdwitxy 44 37 basis basis NN cord-275041-fcdwitxy 44 38 to to IN cord-275041-fcdwitxy 44 39 patients patient NNS cord-275041-fcdwitxy 44 40 who who WP cord-275041-fcdwitxy 44 41 were be VBD cord-275041-fcdwitxy 44 42 taking take VBG cord-275041-fcdwitxy 44 43 it -PRON- PRP cord-275041-fcdwitxy 44 44 . . . cord-275041-fcdwitxy 45 1 HCQ HCQ NNP cord-275041-fcdwitxy 45 2 was be VBD cord-275041-fcdwitxy 45 3 dosed dose VBN cord-275041-fcdwitxy 45 4 as as IN cord-275041-fcdwitxy 45 5 400 400 CD cord-275041-fcdwitxy 45 6 mg mg PRP cord-275041-fcdwitxy 45 7 twice twice RB cord-275041-fcdwitxy 45 8 daily daily RB cord-275041-fcdwitxy 45 9 the the DT cord-275041-fcdwitxy 45 10 first first JJ cord-275041-fcdwitxy 45 11 day day NN cord-275041-fcdwitxy 45 12 , , , cord-275041-fcdwitxy 45 13 followed follow VBN cord-275041-fcdwitxy 45 14 by by IN cord-275041-fcdwitxy 45 15 200 200 CD cord-275041-fcdwitxy 45 16 mg mg NNS cord-275041-fcdwitxy 45 17 twice twice RB cord-275041-fcdwitxy 45 18 daily daily RB cord-275041-fcdwitxy 45 19 for for IN cord-275041-fcdwitxy 45 20 4 4 CD cord-275041-fcdwitxy 45 21 - - SYM cord-275041-fcdwitxy 45 22 6 6 CD cord-275041-fcdwitxy 45 23 days day NNS cord-275041-fcdwitxy 45 24 . . . cord-275041-fcdwitxy 46 1 Data datum NNS cord-275041-fcdwitxy 46 2 on on IN cord-275041-fcdwitxy 46 3 treatments treatment NNS cord-275041-fcdwitxy 46 4 with with IN cord-275041-fcdwitxy 46 5 azithromycin azithromycin NNP cord-275041-fcdwitxy 46 6 , , , cord-275041-fcdwitxy 46 7 steroids steroid NNS cord-275041-fcdwitxy 46 8 , , , cord-275041-fcdwitxy 46 9 heparin heparin NN cord-275041-fcdwitxy 46 10 , , , cord-275041-fcdwitxy 46 11 tocilizumab tocilizumab NNP cord-275041-fcdwitxy 46 12 , , , cord-275041-fcdwitxy 46 13 a a DT cord-275041-fcdwitxy 46 14 combination combination NN cord-275041-fcdwitxy 46 15 of of IN cord-275041-fcdwitxy 46 16 lopinavir lopinavir NNS cord-275041-fcdwitxy 46 17 with with IN cord-275041-fcdwitxy 46 18 ritonavir ritonavir NNP cord-275041-fcdwitxy 46 19 , , , cord-275041-fcdwitxy 46 20 and and CC cord-275041-fcdwitxy 46 21 oseltamivir oseltamivir NNP cord-275041-fcdwitxy 46 22 , , , cord-275041-fcdwitxy 46 23 were be VBD cord-275041-fcdwitxy 46 24 collected collect VBN cord-275041-fcdwitxy 46 25 , , , cord-275041-fcdwitxy 46 26 as as RB cord-275041-fcdwitxy 46 27 well well RB cord-275041-fcdwitxy 46 28 . . . cord-275041-fcdwitxy 47 1 The the DT cord-275041-fcdwitxy 47 2 limited limited JJ cord-275041-fcdwitxy 47 3 evidence evidence NN cord-275041-fcdwitxy 47 4 on on IN cord-275041-fcdwitxy 47 5 which which WDT cord-275041-fcdwitxy 47 6 these these DT cord-275041-fcdwitxy 47 7 treatments treatment NNS cord-275041-fcdwitxy 47 8 were be VBD cord-275041-fcdwitxy 47 9 based base VBN cord-275041-fcdwitxy 47 10 , , , cord-275041-fcdwitxy 47 11 and and CC cord-275041-fcdwitxy 47 12 the the DT cord-275041-fcdwitxy 47 13 rapidly rapidly RB cord-275041-fcdwitxy 47 14 evolving evolve VBG cord-275041-fcdwitxy 47 15 clinical clinical JJ cord-275041-fcdwitxy 47 16 protocols protocol NNS cord-275041-fcdwitxy 47 17 , , , cord-275041-fcdwitxy 47 18 resulted result VBD cord-275041-fcdwitxy 47 19 in in IN cord-275041-fcdwitxy 47 20 these these DT cord-275041-fcdwitxy 47 21 drugs drug NNS cord-275041-fcdwitxy 47 22 being be VBG cord-275041-fcdwitxy 47 23 given give VBN cord-275041-fcdwitxy 47 24 in in IN cord-275041-fcdwitxy 47 25 many many JJ cord-275041-fcdwitxy 47 26 different different JJ cord-275041-fcdwitxy 47 27 specific specific JJ cord-275041-fcdwitxy 47 28 preparations preparation NNS cord-275041-fcdwitxy 47 29 , , , cord-275041-fcdwitxy 47 30 doses dose NNS cord-275041-fcdwitxy 47 31 , , , cord-275041-fcdwitxy 47 32 and and CC cord-275041-fcdwitxy 47 33 frequency frequency NN cord-275041-fcdwitxy 47 34 . . . cord-275041-fcdwitxy 48 1 No no DT cord-275041-fcdwitxy 48 2 information information NN cord-275041-fcdwitxy 48 3 on on IN cord-275041-fcdwitxy 48 4 specific specific JJ cord-275041-fcdwitxy 48 5 preparations preparation NNS cord-275041-fcdwitxy 48 6 of of IN cord-275041-fcdwitxy 48 7 these these DT cord-275041-fcdwitxy 48 8 drugs drug NNS cord-275041-fcdwitxy 48 9 , , , cord-275041-fcdwitxy 48 10 dosage dosage NN cord-275041-fcdwitxy 48 11 , , , cord-275041-fcdwitxy 48 12 duration duration NN cord-275041-fcdwitxy 48 13 of of IN cord-275041-fcdwitxy 48 14 treatment treatment NN cord-275041-fcdwitxy 48 15 , , , cord-275041-fcdwitxy 48 16 or or CC cord-275041-fcdwitxy 48 17 route route NN cord-275041-fcdwitxy 48 18 of of IN cord-275041-fcdwitxy 48 19 administration administration NN cord-275041-fcdwitxy 48 20 , , , cord-275041-fcdwitxy 48 21 were be VBD cord-275041-fcdwitxy 48 22 collected collect VBN cord-275041-fcdwitxy 48 23 . . . cord-275041-fcdwitxy 49 1 Finally finally RB cord-275041-fcdwitxy 49 2 , , , cord-275041-fcdwitxy 49 3 data datum NNS cord-275041-fcdwitxy 49 4 on on IN cord-275041-fcdwitxy 49 5 death death NN cord-275041-fcdwitxy 49 6 were be VBD cord-275041-fcdwitxy 49 7 recorded record VBN cord-275041-fcdwitxy 49 8 . . . cord-275041-fcdwitxy 50 1 The the DT cord-275041-fcdwitxy 50 2 age age NN cord-275041-fcdwitxy 50 3 of of IN cord-275041-fcdwitxy 50 4 patients patient NNS cord-275041-fcdwitxy 50 5 treated treat VBN cord-275041-fcdwitxy 50 6 and and CC cord-275041-fcdwitxy 50 7 not not RB cord-275041-fcdwitxy 50 8 treated treat VBN cord-275041-fcdwitxy 50 9 with with IN cord-275041-fcdwitxy 50 10 HCQ HCQ NNP cord-275041-fcdwitxy 50 11 was be VBD cord-275041-fcdwitxy 50 12 compared compare VBN cord-275041-fcdwitxy 50 13 with with IN cord-275041-fcdwitxy 50 14 t t NN cord-275041-fcdwitxy 50 15 tests test NNS cord-275041-fcdwitxy 50 16 . . . cord-275041-fcdwitxy 51 1 The the DT cord-275041-fcdwitxy 51 2 proportion proportion NN cord-275041-fcdwitxy 51 3 of of IN cord-275041-fcdwitxy 51 4 men man NNS cord-275041-fcdwitxy 51 5 and and CC cord-275041-fcdwitxy 51 6 women woman NNS cord-275041-fcdwitxy 51 7 for for IN cord-275041-fcdwitxy 51 8 those those DT cord-275041-fcdwitxy 51 9 treated treat VBN cord-275041-fcdwitxy 51 10 and and CC cord-275041-fcdwitxy 51 11 not not RB cord-275041-fcdwitxy 51 12 treated treat VBN cord-275041-fcdwitxy 51 13 with with IN cord-275041-fcdwitxy 51 14 HCQ HCQ NNP cord-275041-fcdwitxy 51 15 was be VBD cord-275041-fcdwitxy 51 16 compared compare VBN cord-275041-fcdwitxy 51 17 with with IN cord-275041-fcdwitxy 51 18 Chi Chi NNP cord-275041-fcdwitxy 51 19 - - HYPH cord-275041-fcdwitxy 51 20 squared square VBN cord-275041-fcdwitxy 51 21 tests test NNS cord-275041-fcdwitxy 51 22 . . . cord-275041-fcdwitxy 52 1 The the DT cord-275041-fcdwitxy 52 2 association association NN cord-275041-fcdwitxy 52 3 between between IN cord-275041-fcdwitxy 52 4 treatment treatment NN cord-275041-fcdwitxy 52 5 with with IN cord-275041-fcdwitxy 52 6 HCQ hcq NN cord-275041-fcdwitxy 52 7 and and CC cord-275041-fcdwitxy 52 8 mortality mortality NN cord-275041-fcdwitxy 52 9 was be VBD cord-275041-fcdwitxy 52 10 examined examine VBN cord-275041-fcdwitxy 52 11 with with IN cord-275041-fcdwitxy 52 12 four four CD cord-275041-fcdwitxy 52 13 different different JJ cord-275041-fcdwitxy 52 14 logistic logistic JJ cord-275041-fcdwitxy 52 15 regression regression NN cord-275041-fcdwitxy 52 16 models model NNS cord-275041-fcdwitxy 52 17 : : : cord-275041-fcdwitxy 52 18 model model VB cord-275041-fcdwitxy 52 19 one one CD cord-275041-fcdwitxy 52 20 was be VBD cord-275041-fcdwitxy 52 21 adjusted adjust VBN cord-275041-fcdwitxy 52 22 for for IN cord-275041-fcdwitxy 52 23 age age NN cord-275041-fcdwitxy 52 24 and and CC cord-275041-fcdwitxy 52 25 gender gender NN cord-275041-fcdwitxy 52 26 ; ; : cord-275041-fcdwitxy 52 27 model model NN cord-275041-fcdwitxy 52 28 two two CD cord-275041-fcdwitxy 52 29 included include VBN cord-275041-fcdwitxy 52 30 age age NN cord-275041-fcdwitxy 52 31 and and CC cord-275041-fcdwitxy 52 32 gender gender NN cord-275041-fcdwitxy 52 33 , , , cord-275041-fcdwitxy 52 34 together together RB cord-275041-fcdwitxy 52 35 with with IN cord-275041-fcdwitxy 52 36 temperature temperature NN cord-275041-fcdwitxy 52 37 > > XX cord-275041-fcdwitxy 52 38 37 37 CD cord-275041-fcdwitxy 52 39 ° ° NN cord-275041-fcdwitxy 52 40 C c NN cord-275041-fcdwitxy 52 41 , , , cord-275041-fcdwitxy 52 42 and and CC cord-275041-fcdwitxy 52 43 saturation saturation NN cord-275041-fcdwitxy 52 44 of of IN cord-275041-fcdwitxy 52 45 oxygen oxygen NN cord-275041-fcdwitxy 52 46 < < XX cord-275041-fcdwitxy 52 47 90 90 CD cord-275041-fcdwitxy 52 48 % % NN cord-275041-fcdwitxy 52 49 on on IN cord-275041-fcdwitxy 52 50 admission admission NN cord-275041-fcdwitxy 52 51 , , , cord-275041-fcdwitxy 52 52 which which WDT cord-275041-fcdwitxy 52 53 were be VBD cord-275041-fcdwitxy 52 54 both both DT cord-275041-fcdwitxy 52 55 associated associate VBN cord-275041-fcdwitxy 52 56 with with IN cord-275041-fcdwitxy 52 57 mortality mortality NN cord-275041-fcdwitxy 52 58 in in IN cord-275041-fcdwitxy 52 59 an an DT cord-275041-fcdwitxy 52 60 exploratory exploratory JJ cord-275041-fcdwitxy 52 61 analysis analysis NN cord-275041-fcdwitxy 52 62 ; ; : cord-275041-fcdwitxy 52 63 model model NNP cord-275041-fcdwitxy 52 64 three three CD cord-275041-fcdwitxy 52 65 had have VBD cord-275041-fcdwitxy 52 66 all all PDT cord-275041-fcdwitxy 52 67 the the DT cord-275041-fcdwitxy 52 68 variables variable NNS cord-275041-fcdwitxy 52 69 previously previously RB cord-275041-fcdwitxy 52 70 mentioned mention VBN cord-275041-fcdwitxy 52 71 together together RB cord-275041-fcdwitxy 52 72 with with IN cord-275041-fcdwitxy 52 73 treatment treatment NN cord-275041-fcdwitxy 52 74 with with IN cord-275041-fcdwitxy 52 75 azithromycin azithromycin NNP cord-275041-fcdwitxy 52 76 , , , cord-275041-fcdwitxy 52 77 steroids steroid NNS cord-275041-fcdwitxy 52 78 , , , cord-275041-fcdwitxy 52 79 heparin heparin NN cord-275041-fcdwitxy 52 80 , , , cord-275041-fcdwitxy 52 81 tocilizumab tocilizumab NNP cord-275041-fcdwitxy 52 82 , , , cord-275041-fcdwitxy 52 83 a a DT cord-275041-fcdwitxy 52 84 combination combination NN cord-275041-fcdwitxy 52 85 of of IN cord-275041-fcdwitxy 52 86 lopinavir lopinavir NNS cord-275041-fcdwitxy 52 87 with with IN cord-275041-fcdwitxy 52 88 ritonavir ritonavir NNP cord-275041-fcdwitxy 52 89 , , , cord-275041-fcdwitxy 52 90 and and CC cord-275041-fcdwitxy 52 91 oseltamivir oseltamivir NN cord-275041-fcdwitxy 52 92 ; ; : cord-275041-fcdwitxy 52 93 finally finally RB cord-275041-fcdwitxy 52 94 , , , cord-275041-fcdwitxy 52 95 to to TO cord-275041-fcdwitxy 52 96 account account VB cord-275041-fcdwitxy 52 97 for for IN cord-275041-fcdwitxy 52 98 the the DT cord-275041-fcdwitxy 52 99 change change NN cord-275041-fcdwitxy 52 100 in in IN cord-275041-fcdwitxy 52 101 clinical clinical JJ cord-275041-fcdwitxy 52 102 management management NN cord-275041-fcdwitxy 52 103 during during IN cord-275041-fcdwitxy 52 104 the the DT cord-275041-fcdwitxy 52 105 study study NN cord-275041-fcdwitxy 52 106 period period NN cord-275041-fcdwitxy 52 107 , , , cord-275041-fcdwitxy 52 108 model model NN cord-275041-fcdwitxy 52 109 four four CD cord-275041-fcdwitxy 52 110 was be VBD cord-275041-fcdwitxy 52 111 adjusted adjust VBN cord-275041-fcdwitxy 52 112 for for IN cord-275041-fcdwitxy 52 113 all all PDT cord-275041-fcdwitxy 52 114 the the DT cord-275041-fcdwitxy 52 115 previously previously RB cord-275041-fcdwitxy 52 116 mentioned mention VBN cord-275041-fcdwitxy 52 117 demographic demographic JJ cord-275041-fcdwitxy 52 118 , , , cord-275041-fcdwitxy 52 119 clinical clinical JJ cord-275041-fcdwitxy 52 120 severity severity NN cord-275041-fcdwitxy 52 121 measures measure NNS cord-275041-fcdwitxy 52 122 , , , cord-275041-fcdwitxy 52 123 and and CC cord-275041-fcdwitxy 52 124 drugs drug NNS cord-275041-fcdwitxy 52 125 , , , cord-275041-fcdwitxy 52 126 together together RB cord-275041-fcdwitxy 52 127 with with IN cord-275041-fcdwitxy 52 128 a a DT cord-275041-fcdwitxy 52 129 categorical categorical JJ cord-275041-fcdwitxy 52 130 variable variable NN cord-275041-fcdwitxy 52 131 for for IN cord-275041-fcdwitxy 52 132 date date NN cord-275041-fcdwitxy 52 133 of of IN cord-275041-fcdwitxy 52 134 admission admission NN cord-275041-fcdwitxy 52 135 ( ( -LRB- cord-275041-fcdwitxy 52 136 before before IN cord-275041-fcdwitxy 52 137 the the DT cord-275041-fcdwitxy 52 138 10th 10th NN cord-275041-fcdwitxy 52 139 of of IN cord-275041-fcdwitxy 52 140 March March NNP cord-275041-fcdwitxy 52 141 , , , cord-275041-fcdwitxy 52 142 11 11 CD cord-275041-fcdwitxy 52 143 - - HYPH cord-275041-fcdwitxy 52 144 20th 20th NN cord-275041-fcdwitxy 52 145 of of IN cord-275041-fcdwitxy 52 146 March March NNP cord-275041-fcdwitxy 52 147 , , , cord-275041-fcdwitxy 52 148 20 20 CD cord-275041-fcdwitxy 52 149 - - HYPH cord-275041-fcdwitxy 52 150 31st 31st NN cord-275041-fcdwitxy 52 151 March March NNP cord-275041-fcdwitxy 52 152 , , , cord-275041-fcdwitxy 52 153 1st-10th 1st-10th NNP cord-275041-fcdwitxy 52 154 of of IN cord-275041-fcdwitxy 52 155 April April NNP cord-275041-fcdwitxy 52 156 , , , cord-275041-fcdwitxy 52 157 and and CC cord-275041-fcdwitxy 52 158 11 11 CD cord-275041-fcdwitxy 52 159 - - HYPH cord-275041-fcdwitxy 52 160 20th 20th NN cord-275041-fcdwitxy 52 161 of of IN cord-275041-fcdwitxy 52 162 April April NNP cord-275041-fcdwitxy 52 163 ) ) -RRB- cord-275041-fcdwitxy 52 164 . . . cord-275041-fcdwitxy 53 1 All all DT cord-275041-fcdwitxy 53 2 covariates covariate NNS cord-275041-fcdwitxy 53 3 included include VBN cord-275041-fcdwitxy 53 4 in in IN cord-275041-fcdwitxy 53 5 the the DT cord-275041-fcdwitxy 53 6 four four CD cord-275041-fcdwitxy 53 7 models model NNS cord-275041-fcdwitxy 53 8 were be VBD cord-275041-fcdwitxy 53 9 considered consider VBN cord-275041-fcdwitxy 53 10 potential potential JJ cord-275041-fcdwitxy 53 11 confounders confounder NNS cord-275041-fcdwitxy 53 12 . . . cord-275041-fcdwitxy 54 1 No no DT cord-275041-fcdwitxy 54 2 further further JJ cord-275041-fcdwitxy 54 3 variables variable NNS cord-275041-fcdwitxy 54 4 were be VBD cord-275041-fcdwitxy 54 5 included include VBN cord-275041-fcdwitxy 54 6 to to TO cord-275041-fcdwitxy 54 7 avoid avoid VB cord-275041-fcdwitxy 54 8 the the DT cord-275041-fcdwitxy 54 9 complex complex JJ cord-275041-fcdwitxy 54 10 interpretation interpretation NN cord-275041-fcdwitxy 54 11 of of IN cord-275041-fcdwitxy 54 12 results result NNS cord-275041-fcdwitxy 54 13 and and CC cord-275041-fcdwitxy 54 14 collinearity collinearity NN cord-275041-fcdwitxy 54 15 . . . cord-275041-fcdwitxy 55 1 The the DT cord-275041-fcdwitxy 55 2 software software NN cord-275041-fcdwitxy 55 3 Stata Stata NNP cord-275041-fcdwitxy 55 4 14.0 14.0 CD cord-275041-fcdwitxy 55 5 was be VBD cord-275041-fcdwitxy 55 6 used use VBN cord-275041-fcdwitxy 55 7 for for IN cord-275041-fcdwitxy 55 8 the the DT cord-275041-fcdwitxy 55 9 analysis analysis NN cord-275041-fcdwitxy 55 10 [ [ -LRB- cord-275041-fcdwitxy 55 11 20 20 CD cord-275041-fcdwitxy 55 12 ] ] -RRB- cord-275041-fcdwitxy 55 13 . . . cord-275041-fcdwitxy 56 1 Missing miss VBG cord-275041-fcdwitxy 56 2 data datum NNS cord-275041-fcdwitxy 56 3 were be VBD cord-275041-fcdwitxy 56 4 treated treat VBN cord-275041-fcdwitxy 56 5 as as IN cord-275041-fcdwitxy 56 6 a a DT cord-275041-fcdwitxy 56 7 separate separate JJ cord-275041-fcdwitxy 56 8 category category NN cord-275041-fcdwitxy 56 9 for for IN cord-275041-fcdwitxy 56 10 temperature temperature NN cord-275041-fcdwitxy 56 11 and and CC cord-275041-fcdwitxy 56 12 oxygen oxygen NN cord-275041-fcdwitxy 56 13 saturation saturation NN cord-275041-fcdwitxy 56 14 . . . cord-275041-fcdwitxy 57 1 Sensitivity sensitivity NN cord-275041-fcdwitxy 57 2 analyses analysis NNS cord-275041-fcdwitxy 57 3 were be VBD cord-275041-fcdwitxy 57 4 made make VBN cord-275041-fcdwitxy 57 5 to to TO cord-275041-fcdwitxy 57 6 compare compare VB cord-275041-fcdwitxy 57 7 estimates estimate NNS cord-275041-fcdwitxy 57 8 based base VBN cord-275041-fcdwitxy 57 9 on on IN cord-275041-fcdwitxy 57 10 using use VBG cord-275041-fcdwitxy 57 11 missing miss VBG cord-275041-fcdwitxy 57 12 data datum NNS cord-275041-fcdwitxy 57 13 as as IN cord-275041-fcdwitxy 57 14 categories category NNS cord-275041-fcdwitxy 57 15 with with IN cord-275041-fcdwitxy 57 16 , , , cord-275041-fcdwitxy 57 17 ( ( -LRB- cord-275041-fcdwitxy 57 18 1 1 CD cord-275041-fcdwitxy 57 19 ) ) -RRB- cord-275041-fcdwitxy 57 20 estimates estimate NNS cord-275041-fcdwitxy 57 21 based base VBN cord-275041-fcdwitxy 57 22 on on IN cord-275041-fcdwitxy 57 23 complete complete JJ cord-275041-fcdwitxy 57 24 data datum NNS cord-275041-fcdwitxy 57 25 dropping drop VBG cord-275041-fcdwitxy 57 26 variables variable NNS cord-275041-fcdwitxy 57 27 with with IN cord-275041-fcdwitxy 57 28 missing miss VBG cord-275041-fcdwitxy 57 29 observations observation NNS cord-275041-fcdwitxy 57 30 , , , cord-275041-fcdwitxy 57 31 and and CC cord-275041-fcdwitxy 57 32 ( ( -LRB- cord-275041-fcdwitxy 57 33 2 2 LS cord-275041-fcdwitxy 57 34 ) ) -RRB- cord-275041-fcdwitxy 57 35 complete complete JJ cord-275041-fcdwitxy 57 36 case case NN cord-275041-fcdwitxy 57 37 analysis analysis NN cord-275041-fcdwitxy 57 38 ; ; : cord-275041-fcdwitxy 57 39 dropping drop VBG cord-275041-fcdwitxy 57 40 cases case NNS cord-275041-fcdwitxy 57 41 with with IN cord-275041-fcdwitxy 57 42 missing miss VBG cord-275041-fcdwitxy 57 43 data datum NNS cord-275041-fcdwitxy 57 44 . . . cord-275041-fcdwitxy 58 1 Among among IN cord-275041-fcdwitxy 58 2 the the DT cord-275041-fcdwitxy 58 3 2075 2075 CD cord-275041-fcdwitxy 58 4 patients patient NNS cord-275041-fcdwitxy 58 5 whose whose WP$ cord-275041-fcdwitxy 58 6 records record NNS cord-275041-fcdwitxy 58 7 were be VBD cord-275041-fcdwitxy 58 8 reviewed review VBN cord-275041-fcdwitxy 58 9 , , , cord-275041-fcdwitxy 58 10 1256 1256 CD cord-275041-fcdwitxy 58 11 were be VBD cord-275041-fcdwitxy 58 12 men man NNS cord-275041-fcdwitxy 58 13 , , , cord-275041-fcdwitxy 58 14 819 819 CD cord-275041-fcdwitxy 58 15 were be VBD cord-275041-fcdwitxy 58 16 women woman NNS cord-275041-fcdwitxy 58 17 , , , cord-275041-fcdwitxy 58 18 and and CC cord-275041-fcdwitxy 58 19 the the DT cord-275041-fcdwitxy 58 20 mean mean JJ cord-275041-fcdwitxy 58 21 age age NN cord-275041-fcdwitxy 58 22 was be VBD cord-275041-fcdwitxy 58 23 67.57 67.57 CD cord-275041-fcdwitxy 58 24 . . . cord-275041-fcdwitxy 59 1 At at IN cord-275041-fcdwitxy 59 2 the the DT cord-275041-fcdwitxy 59 3 time time NN cord-275041-fcdwitxy 59 4 of of IN cord-275041-fcdwitxy 59 5 collecting collect VBG cord-275041-fcdwitxy 59 6 the the DT cord-275041-fcdwitxy 59 7 data datum NNS cord-275041-fcdwitxy 59 8 , , , cord-275041-fcdwitxy 59 9 301 301 CD cord-275041-fcdwitxy 59 10 had have VBD cord-275041-fcdwitxy 59 11 died die VBN cord-275041-fcdwitxy 59 12 , , , cord-275041-fcdwitxy 59 13 1449 1449 CD cord-275041-fcdwitxy 59 14 patients patient NNS cord-275041-fcdwitxy 59 15 had have VBD cord-275041-fcdwitxy 59 16 been be VBN cord-275041-fcdwitxy 59 17 discharged discharge VBN cord-275041-fcdwitxy 59 18 home home RB cord-275041-fcdwitxy 59 19 from from IN cord-275041-fcdwitxy 59 20 hospitals hospital NNS cord-275041-fcdwitxy 59 21 , , , cord-275041-fcdwitxy 59 22 240 240 CD cord-275041-fcdwitxy 59 23 were be VBD cord-275041-fcdwitxy 59 24 still still RB cord-275041-fcdwitxy 59 25 admitted admit VBN cord-275041-fcdwitxy 59 26 , , , cord-275041-fcdwitxy 59 27 and and CC cord-275041-fcdwitxy 59 28 85 85 CD cord-275041-fcdwitxy 59 29 had have VBD cord-275041-fcdwitxy 59 30 been be VBN cord-275041-fcdwitxy 59 31 transferred transfer VBN cord-275041-fcdwitxy 59 32 to to IN cord-275041-fcdwitxy 59 33 hospitals hospital NNS cord-275041-fcdwitxy 59 34 not not RB cord-275041-fcdwitxy 59 35 included include VBN cord-275041-fcdwitxy 59 36 in in IN cord-275041-fcdwitxy 59 37 the the DT cord-275041-fcdwitxy 59 38 study study NN cord-275041-fcdwitxy 59 39 . . . cord-275041-fcdwitxy 60 1 Median median JJ cord-275041-fcdwitxy 60 2 ( ( -LRB- cord-275041-fcdwitxy 60 3 IQR IQR NNP cord-275041-fcdwitxy 60 4 ) ) -RRB- cord-275041-fcdwitxy 60 5 follow follow VB cord-275041-fcdwitxy 60 6 - - HYPH cord-275041-fcdwitxy 60 7 up up RP cord-275041-fcdwitxy 60 8 time time NN cord-275041-fcdwitxy 60 9 was be VBD cord-275041-fcdwitxy 60 10 8 8 CD cord-275041-fcdwitxy 60 11 ( ( -LRB- cord-275041-fcdwitxy 60 12 5 5 CD cord-275041-fcdwitxy 60 13 - - SYM cord-275041-fcdwitxy 60 14 12 12 CD cord-275041-fcdwitxy 60 15 ) ) -RRB- cord-275041-fcdwitxy 60 16 days day NNS cord-275041-fcdwitxy 60 17 . . . cord-275041-fcdwitxy 61 1 Data datum NNS cord-275041-fcdwitxy 61 2 on on IN cord-275041-fcdwitxy 61 3 treatment treatment NN cord-275041-fcdwitxy 61 4 with with IN cord-275041-fcdwitxy 61 5 HCQ HCQ NNP cord-275041-fcdwitxy 61 6 were be VBD cord-275041-fcdwitxy 61 7 available available JJ cord-275041-fcdwitxy 61 8 for for IN cord-275041-fcdwitxy 61 9 2019 2019 CD cord-275041-fcdwitxy 61 10 patients patient NNS cord-275041-fcdwitxy 61 11 . . . cord-275041-fcdwitxy 62 1 There there EX cord-275041-fcdwitxy 62 2 was be VBD cord-275041-fcdwitxy 62 3 a a DT cord-275041-fcdwitxy 62 4 younger young JJR cord-275041-fcdwitxy 62 5 age age NN cord-275041-fcdwitxy 62 6 ( ( -LRB- cord-275041-fcdwitxy 62 7 p p NN cord-275041-fcdwitxy 62 8 < < XX cord-275041-fcdwitxy 62 9 0.001 0.001 CD cord-275041-fcdwitxy 62 10 ) ) -RRB- cord-275041-fcdwitxy 62 11 , , , cord-275041-fcdwitxy 62 12 and and CC cord-275041-fcdwitxy 62 13 a a DT cord-275041-fcdwitxy 62 14 higher high JJR cord-275041-fcdwitxy 62 15 proportion proportion NN cord-275041-fcdwitxy 62 16 of of IN cord-275041-fcdwitxy 62 17 men man NNS cord-275041-fcdwitxy 62 18 ( ( -LRB- cord-275041-fcdwitxy 62 19 p p NN cord-275041-fcdwitxy 62 20 = = SYM cord-275041-fcdwitxy 62 21 0.017 0.017 CD cord-275041-fcdwitxy 62 22 ) ) -RRB- cord-275041-fcdwitxy 62 23 for for IN cord-275041-fcdwitxy 62 24 those those DT cord-275041-fcdwitxy 62 25 who who WP cord-275041-fcdwitxy 62 26 received receive VBD cord-275041-fcdwitxy 62 27 HCQ HCQ NNP cord-275041-fcdwitxy 62 28 . . . cord-275041-fcdwitxy 63 1 Among among IN cord-275041-fcdwitxy 63 2 the the DT cord-275041-fcdwitxy 63 3 1857 1857 CD cord-275041-fcdwitxy 63 4 patients patient NNS cord-275041-fcdwitxy 63 5 who who WP cord-275041-fcdwitxy 63 6 had have VBD cord-275041-fcdwitxy 63 7 been be VBN cord-275041-fcdwitxy 63 8 treated treat VBN cord-275041-fcdwitxy 63 9 with with IN cord-275041-fcdwitxy 63 10 HCQ HCQ NNP cord-275041-fcdwitxy 63 11 , , , cord-275041-fcdwitxy 63 12 237 237 CD cord-275041-fcdwitxy 63 13 had have VBD cord-275041-fcdwitxy 63 14 died die VBN cord-275041-fcdwitxy 63 15 . . . cord-275041-fcdwitxy 64 1 ( ( -LRB- cord-275041-fcdwitxy 64 2 Table table NN cord-275041-fcdwitxy 64 3 1 1 CD cord-275041-fcdwitxy 64 4 ) ) -RRB- cord-275041-fcdwitxy 64 5 . . . cord-275041-fcdwitxy 65 1 HCQ HCQ NNP cord-275041-fcdwitxy 65 2 was be VBD cord-275041-fcdwitxy 65 3 associated associate VBN cord-275041-fcdwitxy 65 4 with with IN cord-275041-fcdwitxy 65 5 lower low JJR cord-275041-fcdwitxy 65 6 mortality mortality NN cord-275041-fcdwitxy 65 7 when when WRB cord-275041-fcdwitxy 65 8 the the DT cord-275041-fcdwitxy 65 9 model model NN cord-275041-fcdwitxy 65 10 was be VBD cord-275041-fcdwitxy 65 11 adjusted adjust VBN cord-275041-fcdwitxy 65 12 for for IN cord-275041-fcdwitxy 65 13 age age NN cord-275041-fcdwitxy 65 14 and and CC cord-275041-fcdwitxy 65 15 gender gender NN cord-275041-fcdwitxy 65 16 with with IN cord-275041-fcdwitxy 65 17 OR or NN cord-275041-fcdwitxy 65 18 : : : cord-275041-fcdwitxy 65 19 0.44 0.44 CD cord-275041-fcdwitxy 65 20 ( ( -LRB- cord-275041-fcdwitxy 65 21 0.29 0.29 CD cord-275041-fcdwitxy 65 22 - - SYM cord-275041-fcdwitxy 65 23 0.67 0.67 CD cord-275041-fcdwitxy 65 24 ) ) -RRB- cord-275041-fcdwitxy 66 1 , , , cord-275041-fcdwitxy 66 2 p p NN cord-275041-fcdwitxy 66 3 value value NN cord-275041-fcdwitxy 66 4 < < XX cord-275041-fcdwitxy 66 5 0.001 0.001 CD cord-275041-fcdwitxy 66 6 . . . cord-275041-fcdwitxy 67 1 When when WRB cord-275041-fcdwitxy 67 2 the the DT cord-275041-fcdwitxy 67 3 model model NN cord-275041-fcdwitxy 67 4 was be VBD cord-275041-fcdwitxy 67 5 adjusted adjust VBN cord-275041-fcdwitxy 67 6 for for IN cord-275041-fcdwitxy 67 7 age age NN cord-275041-fcdwitxy 67 8 , , , cord-275041-fcdwitxy 67 9 gender gender NN cord-275041-fcdwitxy 67 10 , , , cord-275041-fcdwitxy 67 11 together together RB cord-275041-fcdwitxy 67 12 with with IN cord-275041-fcdwitxy 67 13 temperature temperature NN cord-275041-fcdwitxy 67 14 > > XX cord-275041-fcdwitxy 67 15 37 37 CD cord-275041-fcdwitxy 67 16 ° ° NN cord-275041-fcdwitxy 67 17 C c NN cord-275041-fcdwitxy 67 18 and and CC cord-275041-fcdwitxy 67 19 saturation saturation NN cord-275041-fcdwitxy 67 20 of of IN cord-275041-fcdwitxy 67 21 oxygen oxygen NN cord-275041-fcdwitxy 67 22 < < XX cord-275041-fcdwitxy 67 23 90 90 CD cord-275041-fcdwitxy 67 24 % % NN cord-275041-fcdwitxy 67 25 on on IN cord-275041-fcdwitxy 67 26 admission admission NN cord-275041-fcdwitxy 67 27 , , , cord-275041-fcdwitxy 67 28 and and CC cord-275041-fcdwitxy 67 29 also also RB cord-275041-fcdwitxy 67 30 when when WRB cord-275041-fcdwitxy 67 31 the the DT cord-275041-fcdwitxy 67 32 model model NN cord-275041-fcdwitxy 67 33 included include VBD cord-275041-fcdwitxy 67 34 all all PDT cord-275041-fcdwitxy 67 35 the the DT cord-275041-fcdwitxy 67 36 previous previous JJ cord-275041-fcdwitxy 67 37 variables variable NNS cord-275041-fcdwitxy 67 38 plus plus CC cord-275041-fcdwitxy 67 39 treatment treatment NN cord-275041-fcdwitxy 67 40 with with IN cord-275041-fcdwitxy 67 41 all all DT cord-275041-fcdwitxy 67 42 drugs drug NNS cord-275041-fcdwitxy 67 43 , , , cord-275041-fcdwitxy 67 44 the the DT cord-275041-fcdwitxy 67 45 association association NN cord-275041-fcdwitxy 67 46 between between IN cord-275041-fcdwitxy 67 47 use use NN cord-275041-fcdwitxy 67 48 of of IN cord-275041-fcdwitxy 67 49 HCQ hcq NN cord-275041-fcdwitxy 67 50 and and CC cord-275041-fcdwitxy 67 51 lower low JJR cord-275041-fcdwitxy 67 52 mortality mortality NN cord-275041-fcdwitxy 67 53 remained remain VBD cord-275041-fcdwitxy 67 54 significant significant JJ cord-275041-fcdwitxy 67 55 . . . cord-275041-fcdwitxy 68 1 The the DT cord-275041-fcdwitxy 68 2 analysis analysis NN cord-275041-fcdwitxy 68 3 of of IN cord-275041-fcdwitxy 68 4 interaction interaction NN cord-275041-fcdwitxy 68 5 suggested suggest VBD cord-275041-fcdwitxy 68 6 that that IN cord-275041-fcdwitxy 68 7 HCQ HCQ NNP cord-275041-fcdwitxy 68 8 was be VBD cord-275041-fcdwitxy 68 9 associated associate VBN cord-275041-fcdwitxy 68 10 with with IN cord-275041-fcdwitxy 68 11 lower low JJR cord-275041-fcdwitxy 68 12 mortality mortality NN cord-275041-fcdwitxy 68 13 , , , cord-275041-fcdwitxy 68 14 and and CC cord-275041-fcdwitxy 68 15 there there EX cord-275041-fcdwitxy 68 16 was be VBD cord-275041-fcdwitxy 68 17 no no DT cord-275041-fcdwitxy 68 18 difference difference NN cord-275041-fcdwitxy 68 19 for for IN cord-275041-fcdwitxy 68 20 those those DT cord-275041-fcdwitxy 68 21 taking take VBG cord-275041-fcdwitxy 68 22 ( ( -LRB- cord-275041-fcdwitxy 68 23 n n NN cord-275041-fcdwitxy 68 24 = = SYM cord-275041-fcdwitxy 68 25 1187 1187 CD cord-275041-fcdwitxy 68 26 ) ) -RRB- cord-275041-fcdwitxy 68 27 , , , cord-275041-fcdwitxy 68 28 or or CC cord-275041-fcdwitxy 68 29 not not RB cord-275041-fcdwitxy 68 30 ( ( -LRB- cord-275041-fcdwitxy 68 31 n n NN cord-275041-fcdwitxy 68 32 = = SYM cord-275041-fcdwitxy 68 33 670 670 CD cord-275041-fcdwitxy 68 34 ) ) -RRB- cord-275041-fcdwitxy 68 35 , , , cord-275041-fcdwitxy 68 36 azithromycin azithromycin NNP cord-275041-fcdwitxy 68 37 , , , cord-275041-fcdwitxy 68 38 as as RB cord-275041-fcdwitxy 68 39 well well RB cord-275041-fcdwitxy 68 40 . . . cord-275041-fcdwitxy 69 1 In in IN cord-275041-fcdwitxy 69 2 the the DT cord-275041-fcdwitxy 69 3 final final JJ cord-275041-fcdwitxy 69 4 model model NN cord-275041-fcdwitxy 69 5 where where WRB cord-275041-fcdwitxy 69 6 all all PDT cord-275041-fcdwitxy 69 7 the the DT cord-275041-fcdwitxy 69 8 previous previous JJ cord-275041-fcdwitxy 69 9 demographic demographic JJ cord-275041-fcdwitxy 69 10 , , , cord-275041-fcdwitxy 69 11 clinical clinical JJ cord-275041-fcdwitxy 69 12 variables variable NNS cord-275041-fcdwitxy 69 13 , , , cord-275041-fcdwitxy 69 14 and and CC cord-275041-fcdwitxy 69 15 drugs drug NNS cord-275041-fcdwitxy 69 16 were be VBD cord-275041-fcdwitxy 69 17 introduced introduce VBN cord-275041-fcdwitxy 69 18 , , , cord-275041-fcdwitxy 69 19 together together RB cord-275041-fcdwitxy 69 20 with with IN cord-275041-fcdwitxy 69 21 time time NN cord-275041-fcdwitxy 69 22 of of IN cord-275041-fcdwitxy 69 23 admission admission NN cord-275041-fcdwitxy 69 24 , , , cord-275041-fcdwitxy 69 25 the the DT cord-275041-fcdwitxy 69 26 association association NN cord-275041-fcdwitxy 69 27 between between IN cord-275041-fcdwitxy 69 28 treatment treatment NN cord-275041-fcdwitxy 69 29 with with IN cord-275041-fcdwitxy 69 30 HCQ hcq NN cord-275041-fcdwitxy 69 31 and and CC cord-275041-fcdwitxy 69 32 lower low JJR cord-275041-fcdwitxy 69 33 mortality mortality NN cord-275041-fcdwitxy 69 34 was be VBD cord-275041-fcdwitxy 69 35 also also RB cord-275041-fcdwitxy 69 36 significant significant JJ cord-275041-fcdwitxy 69 37 . . . cord-275041-fcdwitxy 70 1 ( ( -LRB- cord-275041-fcdwitxy 70 2 Table table NN cord-275041-fcdwitxy 70 3 2 2 CD cord-275041-fcdwitxy 70 4 ) ) -RRB- cord-275041-fcdwitxy 70 5 . . . cord-275041-fcdwitxy 71 1 Treatment treatment NN cord-275041-fcdwitxy 71 2 with with IN cord-275041-fcdwitxy 71 3 HCQ HCQ NNP cord-275041-fcdwitxy 71 4 was be VBD cord-275041-fcdwitxy 71 5 associated associate VBN cord-275041-fcdwitxy 71 6 with with IN cord-275041-fcdwitxy 71 7 lower low JJR cord-275041-fcdwitxy 71 8 mortality mortality NN cord-275041-fcdwitxy 71 9 in in IN cord-275041-fcdwitxy 71 10 patients patient NNS cord-275041-fcdwitxy 71 11 admitted admit VBN cord-275041-fcdwitxy 71 12 with with IN cord-275041-fcdwitxy 71 13 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 71 14 . . . cord-275041-fcdwitxy 72 1 This this DT cord-275041-fcdwitxy 72 2 study study NN cord-275041-fcdwitxy 72 3 has have VBZ cord-275041-fcdwitxy 72 4 strengths strength NNS cord-275041-fcdwitxy 72 5 and and CC cord-275041-fcdwitxy 72 6 limitations limitation NNS cord-275041-fcdwitxy 72 7 . . . cord-275041-fcdwitxy 73 1 Patients patient NNS cord-275041-fcdwitxy 73 2 were be VBD cord-275041-fcdwitxy 73 3 not not RB cord-275041-fcdwitxy 73 4 randomized randomized JJ cord-275041-fcdwitxy 73 5 and and CC cord-275041-fcdwitxy 73 6 the the DT cord-275041-fcdwitxy 73 7 differences difference NNS cord-275041-fcdwitxy 73 8 in in IN cord-275041-fcdwitxy 73 9 mortality mortality NN cord-275041-fcdwitxy 73 10 may may MD cord-275041-fcdwitxy 73 11 be be VB cord-275041-fcdwitxy 73 12 explained explain VBN cord-275041-fcdwitxy 73 13 by by IN cord-275041-fcdwitxy 73 14 factors factor NNS cord-275041-fcdwitxy 73 15 other other JJ cord-275041-fcdwitxy 73 16 than than IN cord-275041-fcdwitxy 73 17 the the DT cord-275041-fcdwitxy 73 18 use use NN cord-275041-fcdwitxy 73 19 of of IN cord-275041-fcdwitxy 73 20 HCQ HCQ NNP cord-275041-fcdwitxy 73 21 . . . cord-275041-fcdwitxy 74 1 In in IN cord-275041-fcdwitxy 74 2 an an DT cord-275041-fcdwitxy 74 3 effort effort NN cord-275041-fcdwitxy 74 4 to to TO cord-275041-fcdwitxy 74 5 control control VB cord-275041-fcdwitxy 74 6 for for IN cord-275041-fcdwitxy 74 7 the the DT cord-275041-fcdwitxy 74 8 severity severity NN cord-275041-fcdwitxy 74 9 of of IN cord-275041-fcdwitxy 74 10 disease disease NN cord-275041-fcdwitxy 74 11 , , , cord-275041-fcdwitxy 74 12 available available JJ cord-275041-fcdwitxy 74 13 markers marker NNS cord-275041-fcdwitxy 74 14 were be VBD cord-275041-fcdwitxy 74 15 considered consider VBN cord-275041-fcdwitxy 74 16 , , , cord-275041-fcdwitxy 74 17 and and CC cord-275041-fcdwitxy 74 18 adjusted adjust VBN cord-275041-fcdwitxy 74 19 for for IN cord-275041-fcdwitxy 74 20 , , , cord-275041-fcdwitxy 74 21 in in IN cord-275041-fcdwitxy 74 22 all all PDT cord-275041-fcdwitxy 74 23 the the DT cord-275041-fcdwitxy 74 24 models model NNS cord-275041-fcdwitxy 74 25 . . . cord-275041-fcdwitxy 75 1 The the DT cord-275041-fcdwitxy 75 2 observation observation NN cord-275041-fcdwitxy 75 3 of of IN cord-275041-fcdwitxy 75 4 a a DT cord-275041-fcdwitxy 75 5 large large JJ cord-275041-fcdwitxy 75 6 number number NN cord-275041-fcdwitxy 75 7 of of IN cord-275041-fcdwitxy 75 8 unselected unselected JJ cord-275041-fcdwitxy 75 9 patients patient NNS cord-275041-fcdwitxy 75 10 admitted admit VBN cord-275041-fcdwitxy 75 11 in in IN cord-275041-fcdwitxy 75 12 17 17 CD cord-275041-fcdwitxy 75 13 hospitals hospital NNS cord-275041-fcdwitxy 75 14 , , , cord-275041-fcdwitxy 75 15 and and CC cord-275041-fcdwitxy 75 16 the the DT cord-275041-fcdwitxy 75 17 analyses analysis NNS cord-275041-fcdwitxy 75 18 run run VBP cord-275041-fcdwitxy 75 19 with with IN cord-275041-fcdwitxy 75 20 some some DT cord-275041-fcdwitxy 75 21 variations variation NNS cord-275041-fcdwitxy 75 22 to to TO cord-275041-fcdwitxy 75 23 test test VB cord-275041-fcdwitxy 75 24 the the DT cord-275041-fcdwitxy 75 25 consistency consistency NN cord-275041-fcdwitxy 75 26 of of IN cord-275041-fcdwitxy 75 27 the the DT cord-275041-fcdwitxy 75 28 results result NNS cord-275041-fcdwitxy 75 29 are be VBP cord-275041-fcdwitxy 75 30 also also RB cord-275041-fcdwitxy 75 31 strengths strength NNS cord-275041-fcdwitxy 75 32 of of IN cord-275041-fcdwitxy 75 33 this this DT cord-275041-fcdwitxy 75 34 study study NN cord-275041-fcdwitxy 75 35 . . . cord-275041-fcdwitxy 76 1 However however RB cord-275041-fcdwitxy 76 2 , , , cord-275041-fcdwitxy 76 3 residual residual JJ cord-275041-fcdwitxy 76 4 confounding confounding NN cord-275041-fcdwitxy 76 5 is be VBZ cord-275041-fcdwitxy 76 6 always always RB cord-275041-fcdwitxy 76 7 present present JJ cord-275041-fcdwitxy 76 8 in in IN cord-275041-fcdwitxy 76 9 all all DT cord-275041-fcdwitxy 76 10 observational observational JJ cord-275041-fcdwitxy 76 11 research research NN cord-275041-fcdwitxy 76 12 . . . cord-275041-fcdwitxy 77 1 The the DT cord-275041-fcdwitxy 77 2 association association NN cord-275041-fcdwitxy 77 3 , , , cord-275041-fcdwitxy 77 4 that that WDT cord-275041-fcdwitxy 77 5 was be VBD cord-275041-fcdwitxy 77 6 consistent consistent JJ cord-275041-fcdwitxy 77 7 across across IN cord-275041-fcdwitxy 77 8 a a DT cord-275041-fcdwitxy 77 9 set set NN cord-275041-fcdwitxy 77 10 of of IN cord-275041-fcdwitxy 77 11 models model NNS cord-275041-fcdwitxy 77 12 that that WDT cord-275041-fcdwitxy 77 13 adjusted adjust VBD cord-275041-fcdwitxy 77 14 for for IN cord-275041-fcdwitxy 77 15 different different JJ cord-275041-fcdwitxy 77 16 potential potential JJ cord-275041-fcdwitxy 77 17 confounders confounder NNS cord-275041-fcdwitxy 77 18 , , , cord-275041-fcdwitxy 77 19 provides provide VBZ cord-275041-fcdwitxy 77 20 support support NN cord-275041-fcdwitxy 77 21 to to IN cord-275041-fcdwitxy 77 22 an an DT cord-275041-fcdwitxy 77 23 independent independent JJ cord-275041-fcdwitxy 77 24 positive positive JJ cord-275041-fcdwitxy 77 25 effect effect NN cord-275041-fcdwitxy 77 26 of of IN cord-275041-fcdwitxy 77 27 HCQ HCQ NNP cord-275041-fcdwitxy 77 28 . . . cord-275041-fcdwitxy 78 1 For for IN cord-275041-fcdwitxy 78 2 all all DT cord-275041-fcdwitxy 78 3 models model NNS cord-275041-fcdwitxy 78 4 , , , cord-275041-fcdwitxy 78 5 the the DT cord-275041-fcdwitxy 78 6 sensitivity sensitivity NN cord-275041-fcdwitxy 78 7 analyses analysis NNS cord-275041-fcdwitxy 78 8 described describe VBN cord-275041-fcdwitxy 78 9 in in IN cord-275041-fcdwitxy 78 10 methods method NNS cord-275041-fcdwitxy 78 11 were be VBD cord-275041-fcdwitxy 78 12 used use VBN cord-275041-fcdwitxy 78 13 to to TO cord-275041-fcdwitxy 78 14 assess assess VB cord-275041-fcdwitxy 78 15 the the DT cord-275041-fcdwitxy 78 16 impact impact NN cord-275041-fcdwitxy 78 17 of of IN cord-275041-fcdwitxy 78 18 missing miss VBG cord-275041-fcdwitxy 78 19 data datum NNS cord-275041-fcdwitxy 78 20 on on IN cord-275041-fcdwitxy 78 21 the the DT cord-275041-fcdwitxy 78 22 two two CD cord-275041-fcdwitxy 78 23 markers marker NNS cord-275041-fcdwitxy 78 24 of of IN cord-275041-fcdwitxy 78 25 disease disease NN cord-275041-fcdwitxy 78 26 severity severity NN cord-275041-fcdwitxy 78 27 , , , cord-275041-fcdwitxy 78 28 and and CC cord-275041-fcdwitxy 78 29 results result NNS cord-275041-fcdwitxy 78 30 were be VBD cord-275041-fcdwitxy 78 31 consistent consistent JJ cord-275041-fcdwitxy 78 32 with with IN cord-275041-fcdwitxy 78 33 those those DT cord-275041-fcdwitxy 78 34 presented present VBN cord-275041-fcdwitxy 78 35 . . . cord-275041-fcdwitxy 79 1 HCQ HCQ NNP cord-275041-fcdwitxy 79 2 has have VBZ cord-275041-fcdwitxy 79 3 been be VBN cord-275041-fcdwitxy 79 4 used use VBN cord-275041-fcdwitxy 79 5 in in IN cord-275041-fcdwitxy 79 6 all all DT cord-275041-fcdwitxy 79 7 phases phase NNS cord-275041-fcdwitxy 79 8 of of IN cord-275041-fcdwitxy 79 9 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 79 10 since since IN cord-275041-fcdwitxy 79 11 two two CD cord-275041-fcdwitxy 79 12 studies study NNS cord-275041-fcdwitxy 79 13 , , , cord-275041-fcdwitxy 79 14 with with IN cord-275041-fcdwitxy 79 15 no no DT cord-275041-fcdwitxy 79 16 control control NN cord-275041-fcdwitxy 79 17 arm arm NN cord-275041-fcdwitxy 79 18 and and CC cord-275041-fcdwitxy 79 19 small small JJ cord-275041-fcdwitxy 79 20 sample sample NN cord-275041-fcdwitxy 79 21 size size NN cord-275041-fcdwitxy 79 22 , , , cord-275041-fcdwitxy 79 23 published publish VBN cord-275041-fcdwitxy 79 24 in in IN cord-275041-fcdwitxy 79 25 March March NNP cord-275041-fcdwitxy 79 26 2020 2020 CD cord-275041-fcdwitxy 79 27 , , , cord-275041-fcdwitxy 79 28 reported report VBD cord-275041-fcdwitxy 79 29 it -PRON- PRP cord-275041-fcdwitxy 79 30 to to TO cord-275041-fcdwitxy 79 31 be be VB cord-275041-fcdwitxy 79 32 associated associate VBN cord-275041-fcdwitxy 79 33 with with IN cord-275041-fcdwitxy 79 34 a a DT cord-275041-fcdwitxy 79 35 reduction reduction NN cord-275041-fcdwitxy 79 36 of of IN cord-275041-fcdwitxy 79 37 the the DT cord-275041-fcdwitxy 79 38 viral viral JJ cord-275041-fcdwitxy 79 39 carriage carriage NN cord-275041-fcdwitxy 79 40 and and CC cord-275041-fcdwitxy 79 41 clinical clinical JJ cord-275041-fcdwitxy 79 42 improvement improvement NN cord-275041-fcdwitxy 79 43 [ [ -LRB- cord-275041-fcdwitxy 79 44 9 9 CD cord-275041-fcdwitxy 79 45 , , , cord-275041-fcdwitxy 79 46 10 10 CD cord-275041-fcdwitxy 79 47 , , , cord-275041-fcdwitxy 79 48 21 21 CD cord-275041-fcdwitxy 79 49 ] ] -RRB- cord-275041-fcdwitxy 79 50 . . . cord-275041-fcdwitxy 80 1 This this DT cord-275041-fcdwitxy 80 2 has have VBZ cord-275041-fcdwitxy 80 3 allowed allow VBN cord-275041-fcdwitxy 80 4 for for IN cord-275041-fcdwitxy 80 5 its -PRON- PRP$ cord-275041-fcdwitxy 80 6 effects effect NNS cord-275041-fcdwitxy 80 7 to to TO cord-275041-fcdwitxy 80 8 be be VB cord-275041-fcdwitxy 80 9 observed observe VBN cord-275041-fcdwitxy 80 10 since since IN cord-275041-fcdwitxy 80 11 then then RB cord-275041-fcdwitxy 80 12 in in IN cord-275041-fcdwitxy 80 13 a a DT cord-275041-fcdwitxy 80 14 large large JJ cord-275041-fcdwitxy 80 15 number number NN cord-275041-fcdwitxy 80 16 of of IN cord-275041-fcdwitxy 80 17 different different JJ cord-275041-fcdwitxy 80 18 patients patient NNS cord-275041-fcdwitxy 80 19 in in IN cord-275041-fcdwitxy 80 20 many many JJ cord-275041-fcdwitxy 80 21 countries country NNS cord-275041-fcdwitxy 80 22 . . . cord-275041-fcdwitxy 81 1 Our -PRON- PRP$ cord-275041-fcdwitxy 81 2 results result NNS cord-275041-fcdwitxy 81 3 , , , cord-275041-fcdwitxy 81 4 showing show VBG cord-275041-fcdwitxy 81 5 that that IN cord-275041-fcdwitxy 81 6 HCQ HCQ NNP cord-275041-fcdwitxy 81 7 is be VBZ cord-275041-fcdwitxy 81 8 associated associate VBN cord-275041-fcdwitxy 81 9 with with IN cord-275041-fcdwitxy 81 10 positive positive JJ cord-275041-fcdwitxy 81 11 outcomes outcome NNS cord-275041-fcdwitxy 81 12 , , , cord-275041-fcdwitxy 81 13 are be VBP cord-275041-fcdwitxy 81 14 consistent consistent JJ cord-275041-fcdwitxy 81 15 with with IN cord-275041-fcdwitxy 81 16 the the DT cord-275041-fcdwitxy 81 17 ones one NNS cord-275041-fcdwitxy 81 18 first first RB cord-275041-fcdwitxy 81 19 reported report VBN cord-275041-fcdwitxy 81 20 in in IN cord-275041-fcdwitxy 81 21 March March NNP cord-275041-fcdwitxy 81 22 2020 2020 CD cord-275041-fcdwitxy 81 23 . . . cord-275041-fcdwitxy 82 1 A a DT cord-275041-fcdwitxy 82 2 number number NN cord-275041-fcdwitxy 82 3 of of IN cord-275041-fcdwitxy 82 4 observational observational JJ cord-275041-fcdwitxy 82 5 studies study NNS cord-275041-fcdwitxy 82 6 later later RB cord-275041-fcdwitxy 82 7 conducted conduct VBN cord-275041-fcdwitxy 82 8 in in IN cord-275041-fcdwitxy 82 9 China China NNP cord-275041-fcdwitxy 82 10 , , , cord-275041-fcdwitxy 82 11 France France NNP cord-275041-fcdwitxy 82 12 , , , cord-275041-fcdwitxy 82 13 Spain Spain NNP cord-275041-fcdwitxy 82 14 ( ( -LRB- cord-275041-fcdwitxy 82 15 in in IN cord-275041-fcdwitxy 82 16 a a DT cord-275041-fcdwitxy 82 17 hospital hospital NN cord-275041-fcdwitxy 82 18 not not RB cord-275041-fcdwitxy 82 19 included include VBN cord-275041-fcdwitxy 82 20 in in IN cord-275041-fcdwitxy 82 21 our -PRON- PRP$ cord-275041-fcdwitxy 82 22 project project NN cord-275041-fcdwitxy 82 23 ) ) -RRB- cord-275041-fcdwitxy 82 24 , , , cord-275041-fcdwitxy 82 25 and and CC cord-275041-fcdwitxy 82 26 the the DT cord-275041-fcdwitxy 82 27 USA USA NNP cord-275041-fcdwitxy 82 28 , , , cord-275041-fcdwitxy 82 29 have have VBP cord-275041-fcdwitxy 82 30 also also RB cord-275041-fcdwitxy 82 31 reported report VBN cord-275041-fcdwitxy 82 32 the the DT cord-275041-fcdwitxy 82 33 association association NN cord-275041-fcdwitxy 82 34 between between IN cord-275041-fcdwitxy 82 35 HCQ HCQ NNP cord-275041-fcdwitxy 82 36 and and CC cord-275041-fcdwitxy 82 37 lower low JJR cord-275041-fcdwitxy 82 38 mortality mortality NN cord-275041-fcdwitxy 82 39 [ [ -LRB- cord-275041-fcdwitxy 82 40 22 22 CD cord-275041-fcdwitxy 82 41 ] ] -RRB- cord-275041-fcdwitxy 83 1 [ [ -LRB- cord-275041-fcdwitxy 83 2 23 23 CD cord-275041-fcdwitxy 83 3 ] ] -RRB- cord-275041-fcdwitxy 84 1 [ [ -LRB- cord-275041-fcdwitxy 84 2 24 24 CD cord-275041-fcdwitxy 84 3 ] ] -RRB- cord-275041-fcdwitxy 84 4 [ [ -LRB- cord-275041-fcdwitxy 84 5 25 25 CD cord-275041-fcdwitxy 84 6 ] ] -RRB- cord-275041-fcdwitxy 84 7 [ [ -LRB- cord-275041-fcdwitxy 84 8 26 26 CD cord-275041-fcdwitxy 84 9 ] ] -RRB- cord-275041-fcdwitxy 84 10 [ [ -LRB- cord-275041-fcdwitxy 84 11 27 27 CD cord-275041-fcdwitxy 84 12 ] ] -RRB- cord-275041-fcdwitxy 84 13 . . . cord-275041-fcdwitxy 85 1 Three three CD cord-275041-fcdwitxy 85 2 of of IN cord-275041-fcdwitxy 85 3 these these DT cord-275041-fcdwitxy 85 4 studies study NNS cord-275041-fcdwitxy 85 5 included include VBN cord-275041-fcdwitxy 85 6 over over IN cord-275041-fcdwitxy 85 7 2000 2000 CD cord-275041-fcdwitxy 85 8 participants participant NNS cord-275041-fcdwitxy 85 9 [ [ -LRB- cord-275041-fcdwitxy 85 10 23 23 CD cord-275041-fcdwitxy 85 11 , , , cord-275041-fcdwitxy 85 12 24 24 CD cord-275041-fcdwitxy 85 13 , , , cord-275041-fcdwitxy 85 14 26 26 CD cord-275041-fcdwitxy 85 15 ] ] -RRB- cord-275041-fcdwitxy 85 16 . . . cord-275041-fcdwitxy 86 1 In in IN cord-275041-fcdwitxy 86 2 one one CD cord-275041-fcdwitxy 86 3 of of IN cord-275041-fcdwitxy 86 4 these these DT cord-275041-fcdwitxy 86 5 studies study NNS cord-275041-fcdwitxy 86 6 , , , cord-275041-fcdwitxy 86 7 only only RB cord-275041-fcdwitxy 86 8 patients patient NNS cord-275041-fcdwitxy 86 9 having have VBG cord-275041-fcdwitxy 86 10 mechanical mechanical JJ cord-275041-fcdwitxy 86 11 ventilation ventilation NN cord-275041-fcdwitxy 86 12 were be VBD cord-275041-fcdwitxy 86 13 included include VBN cord-275041-fcdwitxy 86 14 [ [ -LRB- cord-275041-fcdwitxy 86 15 22 22 CD cord-275041-fcdwitxy 86 16 ] ] -RRB- cord-275041-fcdwitxy 86 17 . . . cord-275041-fcdwitxy 87 1 In in IN cord-275041-fcdwitxy 87 2 another another DT cord-275041-fcdwitxy 87 3 one one NN cord-275041-fcdwitxy 87 4 , , , cord-275041-fcdwitxy 87 5 HCQ HCQ NNP cord-275041-fcdwitxy 87 6 was be VBD cord-275041-fcdwitxy 87 7 also also RB cord-275041-fcdwitxy 87 8 associated associate VBN cord-275041-fcdwitxy 87 9 with with IN cord-275041-fcdwitxy 87 10 lower low JJR cord-275041-fcdwitxy 87 11 probability probability NN cord-275041-fcdwitxy 87 12 of of IN cord-275041-fcdwitxy 87 13 admission admission NN cord-275041-fcdwitxy 87 14 to to IN cord-275041-fcdwitxy 87 15 intensive intensive JJ cord-275041-fcdwitxy 87 16 care care NN cord-275041-fcdwitxy 87 17 , , , cord-275041-fcdwitxy 87 18 shorter short JJR cord-275041-fcdwitxy 87 19 hospital hospital NN cord-275041-fcdwitxy 87 20 admissions admission NNS cord-275041-fcdwitxy 87 21 , , , cord-275041-fcdwitxy 87 22 and and CC cord-275041-fcdwitxy 87 23 shorter short JJR cord-275041-fcdwitxy 87 24 duration duration NN cord-275041-fcdwitxy 87 25 of of IN cord-275041-fcdwitxy 87 26 viral viral JJ cord-275041-fcdwitxy 87 27 shedding shed VBG cord-275041-fcdwitxy 87 28 [ [ -LRB- cord-275041-fcdwitxy 87 29 23 23 CD cord-275041-fcdwitxy 87 30 ] ] -RRB- cord-275041-fcdwitxy 87 31 . . . cord-275041-fcdwitxy 88 1 In in IN cord-275041-fcdwitxy 88 2 two two CD cord-275041-fcdwitxy 88 3 of of IN cord-275041-fcdwitxy 88 4 these these DT cord-275041-fcdwitxy 88 5 studies study NNS cord-275041-fcdwitxy 88 6 , , , cord-275041-fcdwitxy 88 7 favourable favourable JJ cord-275041-fcdwitxy 88 8 results result NNS cord-275041-fcdwitxy 88 9 of of IN cord-275041-fcdwitxy 88 10 HCQ hcq NN cord-275041-fcdwitxy 88 11 combined combine VBN cord-275041-fcdwitxy 88 12 with with IN cord-275041-fcdwitxy 88 13 azithromycin azithromycin NNS cord-275041-fcdwitxy 88 14 were be VBD cord-275041-fcdwitxy 88 15 reported report VBN cord-275041-fcdwitxy 88 16 [ [ -LRB- cord-275041-fcdwitxy 88 17 23 23 CD cord-275041-fcdwitxy 88 18 , , , cord-275041-fcdwitxy 88 19 24 24 CD cord-275041-fcdwitxy 88 20 ] ] -RRB- cord-275041-fcdwitxy 88 21 , , , cord-275041-fcdwitxy 88 22 and and CC cord-275041-fcdwitxy 88 23 in in IN cord-275041-fcdwitxy 88 24 another another DT cord-275041-fcdwitxy 88 25 one one NN cord-275041-fcdwitxy 88 26 , , , cord-275041-fcdwitxy 88 27 the the DT cord-275041-fcdwitxy 88 28 lower low JJR cord-275041-fcdwitxy 88 29 mortality mortality NN cord-275041-fcdwitxy 88 30 was be VBD cord-275041-fcdwitxy 88 31 observed observe VBN cord-275041-fcdwitxy 88 32 for for IN cord-275041-fcdwitxy 88 33 those those DT cord-275041-fcdwitxy 88 34 on on IN cord-275041-fcdwitxy 88 35 HCQ HCQ NNP cord-275041-fcdwitxy 88 36 in in IN cord-275041-fcdwitxy 88 37 combination combination NN cord-275041-fcdwitxy 88 38 with with IN cord-275041-fcdwitxy 88 39 azithromycin azithromycin NN cord-275041-fcdwitxy 88 40 and and CC cord-275041-fcdwitxy 88 41 zinc zinc NN cord-275041-fcdwitxy 88 42 [ [ -LRB- cord-275041-fcdwitxy 88 43 27 27 CD cord-275041-fcdwitxy 88 44 ] ] -RRB- cord-275041-fcdwitxy 88 45 . . . cord-275041-fcdwitxy 89 1 The the DT cord-275041-fcdwitxy 89 2 later later JJ cord-275041-fcdwitxy 89 3 study study NN cord-275041-fcdwitxy 89 4 was be VBD cord-275041-fcdwitxy 89 5 based base VBN cord-275041-fcdwitxy 89 6 on on IN cord-275041-fcdwitxy 89 7 primary primary JJ cord-275041-fcdwitxy 89 8 care care NN cord-275041-fcdwitxy 89 9 , , , cord-275041-fcdwitxy 89 10 and and CC cord-275041-fcdwitxy 89 11 reported report VBD cord-275041-fcdwitxy 89 12 an an DT cord-275041-fcdwitxy 89 13 association association NN cord-275041-fcdwitxy 89 14 between between IN cord-275041-fcdwitxy 89 15 treatment treatment NN cord-275041-fcdwitxy 89 16 and and CC cord-275041-fcdwitxy 89 17 lower low JJR cord-275041-fcdwitxy 89 18 rates rate NNS cord-275041-fcdwitxy 89 19 of of IN cord-275041-fcdwitxy 89 20 hospital hospital NN cord-275041-fcdwitxy 89 21 admissions admission NNS cord-275041-fcdwitxy 89 22 , , , cord-275041-fcdwitxy 89 23 as as RB cord-275041-fcdwitxy 89 24 well well RB cord-275041-fcdwitxy 89 25 . . . cord-275041-fcdwitxy 90 1 Another another DT cord-275041-fcdwitxy 90 2 observational observational JJ cord-275041-fcdwitxy 90 3 study study NN cord-275041-fcdwitxy 90 4 conducted conduct VBN cord-275041-fcdwitxy 90 5 in in IN cord-275041-fcdwitxy 90 6 primary primary JJ cord-275041-fcdwitxy 90 7 care care NN cord-275041-fcdwitxy 90 8 , , , cord-275041-fcdwitxy 90 9 were be VBD cord-275041-fcdwitxy 90 10 mortality mortality NN cord-275041-fcdwitxy 90 11 was be VBD cord-275041-fcdwitxy 90 12 not not RB cord-275041-fcdwitxy 90 13 the the DT cord-275041-fcdwitxy 90 14 outcome outcome NN cord-275041-fcdwitxy 90 15 , , , cord-275041-fcdwitxy 90 16 showed show VBD cord-275041-fcdwitxy 90 17 significantly significantly RB cord-275041-fcdwitxy 90 18 shorter short JJR cord-275041-fcdwitxy 90 19 time time NN cord-275041-fcdwitxy 90 20 to to IN cord-275041-fcdwitxy 90 21 clinical clinical JJ cord-275041-fcdwitxy 90 22 recovery recovery NN cord-275041-fcdwitxy 90 23 for for IN cord-275041-fcdwitxy 90 24 those those DT cord-275041-fcdwitxy 90 25 treated treat VBN cord-275041-fcdwitxy 90 26 with with IN cord-275041-fcdwitxy 90 27 HCQ HCQ NNP cord-275041-fcdwitxy 90 28 or or CC cord-275041-fcdwitxy 90 29 HCQ HCQ NNP cord-275041-fcdwitxy 90 30 plus plus CC cord-275041-fcdwitxy 90 31 azithromycin azithromycin NNP cord-275041-fcdwitxy 90 32 [ [ -LRB- cord-275041-fcdwitxy 90 33 28 28 CD cord-275041-fcdwitxy 90 34 ] ] -RRB- cord-275041-fcdwitxy 90 35 . . . cord-275041-fcdwitxy 91 1 In in IN cord-275041-fcdwitxy 91 2 our -PRON- PRP$ cord-275041-fcdwitxy 91 3 study study NN cord-275041-fcdwitxy 91 4 , , , cord-275041-fcdwitxy 91 5 the the DT cord-275041-fcdwitxy 91 6 addition addition NN cord-275041-fcdwitxy 91 7 of of IN cord-275041-fcdwitxy 91 8 azithromycin azithromycin NN cord-275041-fcdwitxy 91 9 to to IN cord-275041-fcdwitxy 91 10 HCQ HCQ NNP cord-275041-fcdwitxy 91 11 does do VBZ cord-275041-fcdwitxy 91 12 not not RB cord-275041-fcdwitxy 91 13 seem seem VB cord-275041-fcdwitxy 91 14 to to TO cord-275041-fcdwitxy 91 15 add add VB cord-275041-fcdwitxy 91 16 any any DT cord-275041-fcdwitxy 91 17 clear clear JJ cord-275041-fcdwitxy 91 18 benefit benefit NN cord-275041-fcdwitxy 91 19 . . . cord-275041-fcdwitxy 92 1 A a DT cord-275041-fcdwitxy 92 2 large large JJ cord-275041-fcdwitxy 92 3 multicentre multicentre NNP cord-275041-fcdwitxy 92 4 observational observational JJ cord-275041-fcdwitxy 92 5 study study NN cord-275041-fcdwitxy 92 6 reported report VBD cord-275041-fcdwitxy 92 7 no no DT cord-275041-fcdwitxy 92 8 association association NN cord-275041-fcdwitxy 92 9 between between IN cord-275041-fcdwitxy 92 10 HCQ HCQ NNP cord-275041-fcdwitxy 92 11 , , , cord-275041-fcdwitxy 92 12 or or CC cord-275041-fcdwitxy 92 13 HCQ HCQ NNP cord-275041-fcdwitxy 92 14 with with IN cord-275041-fcdwitxy 92 15 azithromycin azithromycin NNP cord-275041-fcdwitxy 92 16 , , , cord-275041-fcdwitxy 92 17 and and CC cord-275041-fcdwitxy 92 18 lower low JJR cord-275041-fcdwitxy 92 19 mortality mortality NN cord-275041-fcdwitxy 92 20 but but CC cord-275041-fcdwitxy 92 21 significantly significantly RB cord-275041-fcdwitxy 92 22 higher high JJR cord-275041-fcdwitxy 92 23 rates rate NNS cord-275041-fcdwitxy 92 24 of of IN cord-275041-fcdwitxy 92 25 discharge discharge NN cord-275041-fcdwitxy 92 26 home home NN cord-275041-fcdwitxy 92 27 were be VBD cord-275041-fcdwitxy 92 28 observed observe VBN cord-275041-fcdwitxy 92 29 for for IN cord-275041-fcdwitxy 92 30 patients patient NNS cord-275041-fcdwitxy 92 31 treated treat VBN cord-275041-fcdwitxy 92 32 by by IN cord-275041-fcdwitxy 92 33 HCQ HCQ NNP cord-275041-fcdwitxy 92 34 [ [ -LRB- cord-275041-fcdwitxy 92 35 29 29 CD cord-275041-fcdwitxy 92 36 ] ] -RRB- cord-275041-fcdwitxy 92 37 . . . cord-275041-fcdwitxy 93 1 In in IN cord-275041-fcdwitxy 93 2 a a DT cord-275041-fcdwitxy 93 3 recent recent JJ cord-275041-fcdwitxy 93 4 meta meta JJ cord-275041-fcdwitxy 93 5 - - HYPH cord-275041-fcdwitxy 93 6 analysis analysis NN cord-275041-fcdwitxy 93 7 , , , cord-275041-fcdwitxy 93 8 studies study NNS cord-275041-fcdwitxy 93 9 were be VBD cord-275041-fcdwitxy 93 10 classified classify VBN cord-275041-fcdwitxy 93 11 as as IN cord-275041-fcdwitxy 93 12 big big JJ cord-275041-fcdwitxy 93 13 data datum NNS cord-275041-fcdwitxy 93 14 , , , cord-275041-fcdwitxy 93 15 when when WRB cord-275041-fcdwitxy 93 16 electronic electronic JJ cord-275041-fcdwitxy 93 17 medical medical JJ cord-275041-fcdwitxy 93 18 records record NNS cord-275041-fcdwitxy 93 19 had have VBD cord-275041-fcdwitxy 93 20 been be VBN cord-275041-fcdwitxy 93 21 used use VBN cord-275041-fcdwitxy 93 22 , , , cord-275041-fcdwitxy 93 23 or or CC cord-275041-fcdwitxy 93 24 clinical clinical JJ cord-275041-fcdwitxy 93 25 studies study NNS cord-275041-fcdwitxy 93 26 , , , cord-275041-fcdwitxy 93 27 when when WRB cord-275041-fcdwitxy 93 28 details detail NNS cord-275041-fcdwitxy 93 29 of of IN cord-275041-fcdwitxy 93 30 treatments treatment NNS cord-275041-fcdwitxy 93 31 were be VBD cord-275041-fcdwitxy 93 32 reported report VBN cord-275041-fcdwitxy 93 33 and and CC cord-275041-fcdwitxy 93 34 the the DT cord-275041-fcdwitxy 93 35 study study NN cord-275041-fcdwitxy 93 36 had have VBD cord-275041-fcdwitxy 93 37 been be VBN cord-275041-fcdwitxy 93 38 conducted conduct VBN cord-275041-fcdwitxy 93 39 by by IN cord-275041-fcdwitxy 93 40 the the DT cord-275041-fcdwitxy 93 41 same same JJ cord-275041-fcdwitxy 93 42 physicians physician NNS cord-275041-fcdwitxy 93 43 who who WP cord-275041-fcdwitxy 93 44 cared care VBD cord-275041-fcdwitxy 93 45 for for IN cord-275041-fcdwitxy 93 46 the the DT cord-275041-fcdwitxy 93 47 patients patient NNS cord-275041-fcdwitxy 93 48 . . . cord-275041-fcdwitxy 94 1 It -PRON- PRP cord-275041-fcdwitxy 94 2 reported report VBD cord-275041-fcdwitxy 94 3 , , , cord-275041-fcdwitxy 94 4 among among IN cord-275041-fcdwitxy 94 5 clinical clinical JJ cord-275041-fcdwitxy 94 6 studies study NNS cord-275041-fcdwitxy 94 7 , , , cord-275041-fcdwitxy 94 8 an an DT cord-275041-fcdwitxy 94 9 association association NN cord-275041-fcdwitxy 94 10 of of IN cord-275041-fcdwitxy 94 11 chloroquine chloroquine NNP cord-275041-fcdwitxy 94 12 derivates derivate NNS cord-275041-fcdwitxy 94 13 with with IN cord-275041-fcdwitxy 94 14 clinical clinical JJ cord-275041-fcdwitxy 94 15 improvement improvement NN cord-275041-fcdwitxy 94 16 , , , cord-275041-fcdwitxy 94 17 lower low JJR cord-275041-fcdwitxy 94 18 mortality mortality NN cord-275041-fcdwitxy 94 19 , , , cord-275041-fcdwitxy 94 20 and and CC cord-275041-fcdwitxy 94 21 viral viral JJ cord-275041-fcdwitxy 94 22 carriage carriage NN cord-275041-fcdwitxy 94 23 [ [ -LRB- cord-275041-fcdwitxy 94 24 30 30 CD cord-275041-fcdwitxy 94 25 ] ] -RRB- cord-275041-fcdwitxy 94 26 . . . cord-275041-fcdwitxy 95 1 Finally finally RB cord-275041-fcdwitxy 95 2 , , , cord-275041-fcdwitxy 95 3 a a DT cord-275041-fcdwitxy 95 4 small small JJ cord-275041-fcdwitxy 95 5 RCT RCT NNP cord-275041-fcdwitxy 95 6 reported report VBD cord-275041-fcdwitxy 95 7 the the DT cord-275041-fcdwitxy 95 8 association association NN cord-275041-fcdwitxy 95 9 of of IN cord-275041-fcdwitxy 95 10 HCQ HCQ NNP cord-275041-fcdwitxy 95 11 with with IN cord-275041-fcdwitxy 95 12 shorter short JJR cord-275041-fcdwitxy 95 13 time time NN cord-275041-fcdwitxy 95 14 both both DT cord-275041-fcdwitxy 95 15 to to IN cord-275041-fcdwitxy 95 16 clinical clinical JJ cord-275041-fcdwitxy 95 17 recovery recovery NN cord-275041-fcdwitxy 95 18 and and CC cord-275041-fcdwitxy 95 19 to to TO cord-275041-fcdwitxy 95 20 reach reach VB cord-275041-fcdwitxy 95 21 viral viral JJ cord-275041-fcdwitxy 95 22 RNA RNA NNP cord-275041-fcdwitxy 95 23 negativity negativity NN cord-275041-fcdwitxy 95 24 [ [ -LRB- cord-275041-fcdwitxy 95 25 31 31 CD cord-275041-fcdwitxy 95 26 ] ] -RRB- cord-275041-fcdwitxy 95 27 . . . cord-275041-fcdwitxy 96 1 The the DT cord-275041-fcdwitxy 96 2 absence absence NN cord-275041-fcdwitxy 96 3 of of IN cord-275041-fcdwitxy 96 4 any any DT cord-275041-fcdwitxy 96 5 positive positive JJ cord-275041-fcdwitxy 96 6 effects effect NNS cord-275041-fcdwitxy 96 7 of of IN cord-275041-fcdwitxy 96 8 the the DT cord-275041-fcdwitxy 96 9 treatment treatment NN cord-275041-fcdwitxy 96 10 with with IN cord-275041-fcdwitxy 96 11 HCQ HCQ NNP cord-275041-fcdwitxy 96 12 has have VBZ cord-275041-fcdwitxy 96 13 also also RB cord-275041-fcdwitxy 96 14 been be VBN cord-275041-fcdwitxy 96 15 reported report VBN cord-275041-fcdwitxy 96 16 . . . cord-275041-fcdwitxy 97 1 A a DT cord-275041-fcdwitxy 97 2 number number NN cord-275041-fcdwitxy 97 3 of of IN cord-275041-fcdwitxy 97 4 observational observational JJ cord-275041-fcdwitxy 97 5 studies study NNS cord-275041-fcdwitxy 97 6 have have VBP cord-275041-fcdwitxy 97 7 reported report VBN cord-275041-fcdwitxy 97 8 that that IN cord-275041-fcdwitxy 97 9 HCQ HCQ NNP cord-275041-fcdwitxy 97 10 , , , cord-275041-fcdwitxy 97 11 either either CC cord-275041-fcdwitxy 97 12 alone alone RB cord-275041-fcdwitxy 97 13 or or CC cord-275041-fcdwitxy 97 14 in in IN cord-275041-fcdwitxy 97 15 combination combination NN cord-275041-fcdwitxy 97 16 with with IN cord-275041-fcdwitxy 97 17 azithromycin azithromycin NNP cord-275041-fcdwitxy 97 18 , , , cord-275041-fcdwitxy 97 19 was be VBD cord-275041-fcdwitxy 97 20 not not RB cord-275041-fcdwitxy 97 21 associated associate VBN cord-275041-fcdwitxy 97 22 with with IN cord-275041-fcdwitxy 97 23 lower low JJR cord-275041-fcdwitxy 97 24 mortality mortality NN cord-275041-fcdwitxy 97 25 [ [ -LRB- cord-275041-fcdwitxy 97 26 32 32 CD cord-275041-fcdwitxy 97 27 ] ] -RRB- cord-275041-fcdwitxy 98 1 [ [ -LRB- cord-275041-fcdwitxy 98 2 33 33 CD cord-275041-fcdwitxy 98 3 ] ] -RRB- cord-275041-fcdwitxy 98 4 [ [ -LRB- cord-275041-fcdwitxy 98 5 34 34 CD cord-275041-fcdwitxy 98 6 ] ] -RRB- cord-275041-fcdwitxy 98 7 [ [ -LRB- cord-275041-fcdwitxy 98 8 35 35 CD cord-275041-fcdwitxy 98 9 ] ] -RRB- cord-275041-fcdwitxy 98 10 . . . cord-275041-fcdwitxy 99 1 Three three CD cord-275041-fcdwitxy 99 2 of of IN cord-275041-fcdwitxy 99 3 these these DT cord-275041-fcdwitxy 99 4 studies study NNS cord-275041-fcdwitxy 99 5 included include VBN cord-275041-fcdwitxy 99 6 over over IN cord-275041-fcdwitxy 99 7 1000 1000 CD cord-275041-fcdwitxy 99 8 participants participant NNS cord-275041-fcdwitxy 99 9 [ [ -LRB- cord-275041-fcdwitxy 99 10 32 32 CD cord-275041-fcdwitxy 99 11 , , , cord-275041-fcdwitxy 99 12 34 34 CD cord-275041-fcdwitxy 99 13 , , , cord-275041-fcdwitxy 99 14 35 35 CD cord-275041-fcdwitxy 99 15 ] ] -RRB- cord-275041-fcdwitxy 99 16 . . . cord-275041-fcdwitxy 100 1 One one CD cord-275041-fcdwitxy 100 2 of of IN cord-275041-fcdwitxy 100 3 these these DT cord-275041-fcdwitxy 100 4 studies study NNS cord-275041-fcdwitxy 100 5 included include VBD cord-275041-fcdwitxy 100 6 patients patient NNS cord-275041-fcdwitxy 100 7 who who WP cord-275041-fcdwitxy 100 8 needed need VBD cord-275041-fcdwitxy 100 9 oxygen oxygen NN cord-275041-fcdwitxy 100 10 [ [ -LRB- cord-275041-fcdwitxy 100 11 33 33 CD cord-275041-fcdwitxy 100 12 ] ] -RRB- cord-275041-fcdwitxy 100 13 and and CC cord-275041-fcdwitxy 100 14 another another DT cord-275041-fcdwitxy 100 15 one one NN cord-275041-fcdwitxy 100 16 used use VBN cord-275041-fcdwitxy 100 17 mortality mortality NN cord-275041-fcdwitxy 100 18 or or CC cord-275041-fcdwitxy 100 19 need need VB cord-275041-fcdwitxy 100 20 for for IN cord-275041-fcdwitxy 100 21 intubation intubation NN cord-275041-fcdwitxy 100 22 as as IN cord-275041-fcdwitxy 100 23 an an DT cord-275041-fcdwitxy 100 24 outcome outcome NN cord-275041-fcdwitxy 100 25 [ [ -LRB- cord-275041-fcdwitxy 100 26 34 34 CD cord-275041-fcdwitxy 100 27 ] ] -RRB- cord-275041-fcdwitxy 101 1 Two two CD cord-275041-fcdwitxy 101 2 RCTs rct NNS cord-275041-fcdwitxy 101 3 have have VBP cord-275041-fcdwitxy 101 4 also also RB cord-275041-fcdwitxy 101 5 reported report VBN cord-275041-fcdwitxy 101 6 no no DT cord-275041-fcdwitxy 101 7 association association NN cord-275041-fcdwitxy 101 8 between between IN cord-275041-fcdwitxy 101 9 HCQ HCQ NNP cord-275041-fcdwitxy 101 10 and and CC cord-275041-fcdwitxy 101 11 survival survival NN cord-275041-fcdwitxy 101 12 [ [ -LRB- cord-275041-fcdwitxy 101 13 36 36 CD cord-275041-fcdwitxy 101 14 , , , cord-275041-fcdwitxy 101 15 37 37 CD cord-275041-fcdwitxy 101 16 ] ] -RRB- cord-275041-fcdwitxy 101 17 . . . cord-275041-fcdwitxy 102 1 One one CD cord-275041-fcdwitxy 102 2 of of IN cord-275041-fcdwitxy 102 3 them -PRON- PRP cord-275041-fcdwitxy 102 4 also also RB cord-275041-fcdwitxy 102 5 reported report VBD cord-275041-fcdwitxy 102 6 no no DT cord-275041-fcdwitxy 102 7 benefit benefit NN cord-275041-fcdwitxy 102 8 in in IN cord-275041-fcdwitxy 102 9 need need NN cord-275041-fcdwitxy 102 10 for for IN cord-275041-fcdwitxy 102 11 admissions admission NNS cord-275041-fcdwitxy 102 12 or or CC cord-275041-fcdwitxy 102 13 clinical clinical JJ cord-275041-fcdwitxy 102 14 improvement improvement NN cord-275041-fcdwitxy 102 15 [ [ -LRB- cord-275041-fcdwitxy 102 16 37 37 CD cord-275041-fcdwitxy 102 17 ] ] -RRB- cord-275041-fcdwitxy 102 18 . . . cord-275041-fcdwitxy 103 1 The the DT cord-275041-fcdwitxy 103 2 lack lack NN cord-275041-fcdwitxy 103 3 of of IN cord-275041-fcdwitxy 103 4 clinical clinical JJ cord-275041-fcdwitxy 103 5 improvement improvement NN cord-275041-fcdwitxy 103 6 was be VBD cord-275041-fcdwitxy 103 7 reported report VBN cord-275041-fcdwitxy 103 8 in in IN cord-275041-fcdwitxy 103 9 another another DT cord-275041-fcdwitxy 103 10 trial trial NN cord-275041-fcdwitxy 103 11 [ [ -LRB- cord-275041-fcdwitxy 103 12 38 38 CD cord-275041-fcdwitxy 103 13 ] ] -RRB- cord-275041-fcdwitxy 103 14 . . . cord-275041-fcdwitxy 104 1 Finally finally RB cord-275041-fcdwitxy 104 2 , , , cord-275041-fcdwitxy 104 3 two two CD cord-275041-fcdwitxy 104 4 more more JJR cord-275041-fcdwitxy 104 5 RCTs rct NNS cord-275041-fcdwitxy 104 6 have have VBP cord-275041-fcdwitxy 104 7 reported report VBN cord-275041-fcdwitxy 104 8 no no DT cord-275041-fcdwitxy 104 9 association association NN cord-275041-fcdwitxy 104 10 between between IN cord-275041-fcdwitxy 104 11 HCQ HCQ NNP cord-275041-fcdwitxy 104 12 and and CC cord-275041-fcdwitxy 104 13 virological virological JJ cord-275041-fcdwitxy 104 14 clearance clearance NN cord-275041-fcdwitxy 104 15 [ [ -LRB- cord-275041-fcdwitxy 104 16 39 39 CD cord-275041-fcdwitxy 104 17 ] ] -RRB- cord-275041-fcdwitxy 104 18 or or CC cord-275041-fcdwitxy 104 19 prevention prevention NN cord-275041-fcdwitxy 104 20 of of IN cord-275041-fcdwitxy 104 21 disease disease NN cord-275041-fcdwitxy 104 22 in in IN cord-275041-fcdwitxy 104 23 individuals individual NNS cord-275041-fcdwitxy 104 24 exposed expose VBN cord-275041-fcdwitxy 104 25 to to IN cord-275041-fcdwitxy 104 26 it -PRON- PRP cord-275041-fcdwitxy 104 27 [ [ -LRB- cord-275041-fcdwitxy 104 28 40 40 CD cord-275041-fcdwitxy 104 29 ] ] -RRB- cord-275041-fcdwitxy 104 30 . . . cord-275041-fcdwitxy 105 1 A a DT cord-275041-fcdwitxy 105 2 number number NN cord-275041-fcdwitxy 105 3 of of IN cord-275041-fcdwitxy 105 4 factors factor NNS cord-275041-fcdwitxy 105 5 could could MD cord-275041-fcdwitxy 105 6 explain explain VB cord-275041-fcdwitxy 105 7 the the DT cord-275041-fcdwitxy 105 8 difference difference NN cord-275041-fcdwitxy 105 9 between between IN cord-275041-fcdwitxy 105 10 our -PRON- PRP$ cord-275041-fcdwitxy 105 11 results result NNS cord-275041-fcdwitxy 105 12 and and CC cord-275041-fcdwitxy 105 13 the the DT cord-275041-fcdwitxy 105 14 ones one NNS cord-275041-fcdwitxy 105 15 observed observe VBN cord-275041-fcdwitxy 105 16 in in IN cord-275041-fcdwitxy 105 17 these these DT cord-275041-fcdwitxy 105 18 studies study NNS cord-275041-fcdwitxy 105 19 [ [ -LRB- cord-275041-fcdwitxy 105 20 32 32 CD cord-275041-fcdwitxy 105 21 ] ] -RRB- cord-275041-fcdwitxy 106 1 [ [ -LRB- cord-275041-fcdwitxy 106 2 33 33 CD cord-275041-fcdwitxy 106 3 ] ] -RRB- cord-275041-fcdwitxy 107 1 [ [ -LRB- cord-275041-fcdwitxy 107 2 34 34 CD cord-275041-fcdwitxy 107 3 ] ] -RRB- cord-275041-fcdwitxy 107 4 [ [ -LRB- cord-275041-fcdwitxy 107 5 35 35 CD cord-275041-fcdwitxy 107 6 ] ] -RRB- cord-275041-fcdwitxy 107 7 [ [ -LRB- cord-275041-fcdwitxy 107 8 36 36 CD cord-275041-fcdwitxy 107 9 ] ] -RRB- cord-275041-fcdwitxy 108 1 [ [ -LRB- cord-275041-fcdwitxy 108 2 37 37 CD cord-275041-fcdwitxy 108 3 ] ] -RRB- cord-275041-fcdwitxy 108 4 [ [ -LRB- cord-275041-fcdwitxy 108 5 38 38 CD cord-275041-fcdwitxy 108 6 ] ] -RRB- cord-275041-fcdwitxy 109 1 [ [ -LRB- cord-275041-fcdwitxy 109 2 39 39 CD cord-275041-fcdwitxy 109 3 ] ] -RRB- cord-275041-fcdwitxy 110 1 [ [ -LRB- cord-275041-fcdwitxy 110 2 40 40 CD cord-275041-fcdwitxy 110 3 ] ] -RRB- cord-275041-fcdwitxy 110 4 including include VBG cord-275041-fcdwitxy 110 5 the the DT cord-275041-fcdwitxy 110 6 following follow VBG cord-275041-fcdwitxy 110 7 : : : cord-275041-fcdwitxy 110 8 the the DT cord-275041-fcdwitxy 110 9 clinical clinical JJ cord-275041-fcdwitxy 110 10 - - HYPH cord-275041-fcdwitxy 110 11 epidemiological epidemiological JJ cord-275041-fcdwitxy 110 12 design design NN cord-275041-fcdwitxy 110 13 of of IN cord-275041-fcdwitxy 110 14 our -PRON- PRP$ cord-275041-fcdwitxy 110 15 work work NN cord-275041-fcdwitxy 110 16 ; ; : cord-275041-fcdwitxy 110 17 [ [ -LRB- cord-275041-fcdwitxy 110 18 30 30 CD cord-275041-fcdwitxy 110 19 ] ] -RRB- cord-275041-fcdwitxy 110 20 the the DT cord-275041-fcdwitxy 110 21 involvement involvement NN cord-275041-fcdwitxy 110 22 of of IN cord-275041-fcdwitxy 110 23 all all DT cord-275041-fcdwitxy 110 24 patients patient NNS cord-275041-fcdwitxy 110 25 admitted admit VBN cord-275041-fcdwitxy 110 26 with with IN cord-275041-fcdwitxy 110 27 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 110 28 , , , cord-275041-fcdwitxy 110 29 regardless regardless RB cord-275041-fcdwitxy 110 30 their -PRON- PRP$ cord-275041-fcdwitxy 110 31 past past JJ cord-275041-fcdwitxy 110 32 medical medical JJ cord-275041-fcdwitxy 110 33 history history NN cord-275041-fcdwitxy 110 34 , , , cord-275041-fcdwitxy 110 35 the the DT cord-275041-fcdwitxy 110 36 time time NN cord-275041-fcdwitxy 110 37 between between IN cord-275041-fcdwitxy 110 38 onset onset NN cord-275041-fcdwitxy 110 39 of of IN cord-275041-fcdwitxy 110 40 symptoms symptom NNS cord-275041-fcdwitxy 110 41 and and CC cord-275041-fcdwitxy 110 42 the the DT cord-275041-fcdwitxy 110 43 start start NN cord-275041-fcdwitxy 110 44 of of IN cord-275041-fcdwitxy 110 45 treatment treatment NN cord-275041-fcdwitxy 110 46 , , , cord-275041-fcdwitxy 110 47 the the DT cord-275041-fcdwitxy 110 48 duration duration NN cord-275041-fcdwitxy 110 49 of of IN cord-275041-fcdwitxy 110 50 admission admission NN cord-275041-fcdwitxy 110 51 , , , cord-275041-fcdwitxy 110 52 and and CC cord-275041-fcdwitxy 110 53 the the DT cord-275041-fcdwitxy 110 54 need need NN cord-275041-fcdwitxy 110 55 for for IN cord-275041-fcdwitxy 110 56 oxygen oxygen NN cord-275041-fcdwitxy 110 57 ; ; : cord-275041-fcdwitxy 110 58 the the DT cord-275041-fcdwitxy 110 59 different different JJ cord-275041-fcdwitxy 110 60 statistical statistical JJ cord-275041-fcdwitxy 110 61 approach approach NN cord-275041-fcdwitxy 110 62 ; ; : cord-275041-fcdwitxy 110 63 and and CC cord-275041-fcdwitxy 110 64 the the DT cord-275041-fcdwitxy 110 65 observation observation NN cord-275041-fcdwitxy 110 66 in in IN cord-275041-fcdwitxy 110 67 our -PRON- PRP$ cord-275041-fcdwitxy 110 68 work work NN cord-275041-fcdwitxy 110 69 of of IN cord-275041-fcdwitxy 110 70 patients patient NNS cord-275041-fcdwitxy 110 71 from from IN cord-275041-fcdwitxy 110 72 private private JJ cord-275041-fcdwitxy 110 73 hospitals hospital NNS cord-275041-fcdwitxy 110 74 , , , cord-275041-fcdwitxy 110 75 who who WP cord-275041-fcdwitxy 110 76 are be VBP cord-275041-fcdwitxy 110 77 likely likely JJ cord-275041-fcdwitxy 110 78 to to TO cord-275041-fcdwitxy 110 79 have have VB cord-275041-fcdwitxy 110 80 a a DT cord-275041-fcdwitxy 110 81 high high JJ cord-275041-fcdwitxy 110 82 socioeconomic socioeconomic JJ cord-275041-fcdwitxy 110 83 status status NN cord-275041-fcdwitxy 110 84 [ [ -LRB- cord-275041-fcdwitxy 110 85 41 41 CD cord-275041-fcdwitxy 110 86 ] ] -RRB- cord-275041-fcdwitxy 110 87 . . . cord-275041-fcdwitxy 111 1 The the DT cord-275041-fcdwitxy 111 2 safety safety NN cord-275041-fcdwitxy 111 3 of of IN cord-275041-fcdwitxy 111 4 the the DT cord-275041-fcdwitxy 111 5 HCQ HCQ NNP cord-275041-fcdwitxy 111 6 has have VBZ cord-275041-fcdwitxy 111 7 been be VBN cord-275041-fcdwitxy 111 8 questioned question VBN cord-275041-fcdwitxy 111 9 , , , cord-275041-fcdwitxy 111 10 as as IN cord-275041-fcdwitxy 111 11 it -PRON- PRP cord-275041-fcdwitxy 111 12 could could MD cord-275041-fcdwitxy 111 13 negatively negatively RB cord-275041-fcdwitxy 111 14 impact impact VB cord-275041-fcdwitxy 111 15 the the DT cord-275041-fcdwitxy 111 16 immune immune JJ cord-275041-fcdwitxy 111 17 response response NN cord-275041-fcdwitxy 111 18 to to IN cord-275041-fcdwitxy 111 19 the the DT cord-275041-fcdwitxy 111 20 virus virus NN cord-275041-fcdwitxy 111 21 , , , cord-275041-fcdwitxy 111 22 or or CC cord-275041-fcdwitxy 111 23 cause cause VB cord-275041-fcdwitxy 111 24 abnormalities abnormality NNS cord-275041-fcdwitxy 111 25 in in IN cord-275041-fcdwitxy 111 26 the the DT cord-275041-fcdwitxy 111 27 ECG ECG NNP cord-275041-fcdwitxy 111 28 [ [ -LRB- cord-275041-fcdwitxy 111 29 33 33 CD cord-275041-fcdwitxy 111 30 , , , cord-275041-fcdwitxy 111 31 42 42 CD cord-275041-fcdwitxy 111 32 , , , cord-275041-fcdwitxy 111 33 43 43 CD cord-275041-fcdwitxy 111 34 ] ] -RRB- cord-275041-fcdwitxy 111 35 . . . cord-275041-fcdwitxy 112 1 However however RB cord-275041-fcdwitxy 112 2 , , , cord-275041-fcdwitxy 112 3 none none NN cord-275041-fcdwitxy 112 4 of of IN cord-275041-fcdwitxy 112 5 the the DT cord-275041-fcdwitxy 112 6 studies study NNS cord-275041-fcdwitxy 112 7 that that WDT cord-275041-fcdwitxy 112 8 we -PRON- PRP cord-275041-fcdwitxy 112 9 have have VBP cord-275041-fcdwitxy 112 10 reviewed review VBN cord-275041-fcdwitxy 112 11 , , , cord-275041-fcdwitxy 112 12 reporting report VBG cord-275041-fcdwitxy 112 13 no no DT cord-275041-fcdwitxy 112 14 benefit benefit NN cord-275041-fcdwitxy 112 15 on on IN cord-275041-fcdwitxy 112 16 HCQ HCQ NNP cord-275041-fcdwitxy 112 17 , , , cord-275041-fcdwitxy 112 18 show show VBP cord-275041-fcdwitxy 112 19 an an DT cord-275041-fcdwitxy 112 20 increased increase VBN cord-275041-fcdwitxy 112 21 mortality mortality NN cord-275041-fcdwitxy 112 22 associated associate VBN cord-275041-fcdwitxy 112 23 with with IN cord-275041-fcdwitxy 112 24 it -PRON- PRP cord-275041-fcdwitxy 112 25 [ [ -LRB- cord-275041-fcdwitxy 112 26 32 32 CD cord-275041-fcdwitxy 112 27 ] ] -RRB- cord-275041-fcdwitxy 112 28 [ [ -LRB- cord-275041-fcdwitxy 112 29 33 33 CD cord-275041-fcdwitxy 112 30 ] ] -RRB- cord-275041-fcdwitxy 112 31 [ [ -LRB- cord-275041-fcdwitxy 112 32 34 34 CD cord-275041-fcdwitxy 112 33 ] ] -RRB- cord-275041-fcdwitxy 112 34 [ [ -LRB- cord-275041-fcdwitxy 112 35 35 35 CD cord-275041-fcdwitxy 112 36 ] ] -RRB- cord-275041-fcdwitxy 112 37 [ [ -LRB- cord-275041-fcdwitxy 112 38 36 36 CD cord-275041-fcdwitxy 112 39 ] ] -RRB- cord-275041-fcdwitxy 112 40 [ [ -LRB- cord-275041-fcdwitxy 112 41 37 37 CD cord-275041-fcdwitxy 112 42 ] ] -RRB- cord-275041-fcdwitxy 112 43 [ [ -LRB- cord-275041-fcdwitxy 112 44 38 38 CD cord-275041-fcdwitxy 112 45 ] ] -RRB- cord-275041-fcdwitxy 112 46 [ [ -LRB- cord-275041-fcdwitxy 112 47 39 39 CD cord-275041-fcdwitxy 112 48 ] ] -RRB- cord-275041-fcdwitxy 112 49 [ [ -LRB- cord-275041-fcdwitxy 112 50 40 40 CD cord-275041-fcdwitxy 112 51 ] ] -RRB- cord-275041-fcdwitxy 112 52 . . . cord-275041-fcdwitxy 113 1 Further further JJ cord-275041-fcdwitxy 113 2 RCTs rct NNS cord-275041-fcdwitxy 113 3 , , , cord-275041-fcdwitxy 113 4 observational observational JJ cord-275041-fcdwitxy 113 5 studies study NNS cord-275041-fcdwitxy 113 6 , , , cord-275041-fcdwitxy 113 7 and and CC cord-275041-fcdwitxy 113 8 summaries summary NNS cord-275041-fcdwitxy 113 9 of of IN cord-275041-fcdwitxy 113 10 both both DT cord-275041-fcdwitxy 113 11 types type NNS cord-275041-fcdwitxy 113 12 of of IN cord-275041-fcdwitxy 113 13 evidence evidence NN cord-275041-fcdwitxy 113 14 to to TO cord-275041-fcdwitxy 113 15 assess assess VB cord-275041-fcdwitxy 113 16 the the DT cord-275041-fcdwitxy 113 17 associations association NNS cord-275041-fcdwitxy 113 18 between between IN cord-275041-fcdwitxy 113 19 HCQ hcq NN cord-275041-fcdwitxy 113 20 and and CC cord-275041-fcdwitxy 113 21 survival survival NN cord-275041-fcdwitxy 113 22 are be VBP cord-275041-fcdwitxy 113 23 necessary necessary JJ cord-275041-fcdwitxy 113 24 . . . cord-275041-fcdwitxy 114 1 Future future JJ cord-275041-fcdwitxy 114 2 studies study NNS cord-275041-fcdwitxy 114 3 could could MD cord-275041-fcdwitxy 114 4 also also RB cord-275041-fcdwitxy 114 5 address address VB cord-275041-fcdwitxy 114 6 at at IN cord-275041-fcdwitxy 114 7 what what WP cord-275041-fcdwitxy 114 8 dosage dosage NN cord-275041-fcdwitxy 114 9 , , , cord-275041-fcdwitxy 114 10 and and CC cord-275041-fcdwitxy 114 11 in in IN cord-275041-fcdwitxy 114 12 what what WDT cord-275041-fcdwitxy 114 13 phase phase NN cord-275041-fcdwitxy 114 14 of of IN cord-275041-fcdwitxy 114 15 the the DT cord-275041-fcdwitxy 114 16 disease disease NN cord-275041-fcdwitxy 114 17 , , , cord-275041-fcdwitxy 114 18 does do VBZ cord-275041-fcdwitxy 114 19 HCQ HCQ NNP cord-275041-fcdwitxy 114 20 lead lead VB cord-275041-fcdwitxy 114 21 to to IN cord-275041-fcdwitxy 114 22 the the DT cord-275041-fcdwitxy 114 23 best good JJS cord-275041-fcdwitxy 114 24 possible possible JJ cord-275041-fcdwitxy 114 25 outcome outcome NN cord-275041-fcdwitxy 114 26 , , , cord-275041-fcdwitxy 114 27 for for IN cord-275041-fcdwitxy 114 28 patients patient NNS cord-275041-fcdwitxy 114 29 with with IN cord-275041-fcdwitxy 114 30 different different JJ cord-275041-fcdwitxy 114 31 past past JJ cord-275041-fcdwitxy 114 32 medical medical JJ cord-275041-fcdwitxy 114 33 histories history NNS cord-275041-fcdwitxy 114 34 [ [ -LRB- cord-275041-fcdwitxy 114 35 44 44 CD cord-275041-fcdwitxy 114 36 ] ] -RRB- cord-275041-fcdwitxy 114 37 . . . cord-275041-fcdwitxy 115 1 The the DT cord-275041-fcdwitxy 115 2 interventional interventional JJ cord-275041-fcdwitxy 115 3 evidence evidence NN cord-275041-fcdwitxy 115 4 on on IN cord-275041-fcdwitxy 115 5 the the DT cord-275041-fcdwitxy 115 6 management management NN cord-275041-fcdwitxy 115 7 of of IN cord-275041-fcdwitxy 115 8 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 115 9 is be VBZ cord-275041-fcdwitxy 115 10 still still RB cord-275041-fcdwitxy 115 11 limited limited JJ cord-275041-fcdwitxy 115 12 . . . cord-275041-fcdwitxy 116 1 Therefore therefore RB cord-275041-fcdwitxy 116 2 , , , cord-275041-fcdwitxy 116 3 clinicians clinician NNS cord-275041-fcdwitxy 116 4 could could MD cord-275041-fcdwitxy 116 5 acknowledge acknowledge VB cord-275041-fcdwitxy 116 6 the the DT cord-275041-fcdwitxy 116 7 results result NNS cord-275041-fcdwitxy 116 8 presented present VBN cord-275041-fcdwitxy 116 9 in in IN cord-275041-fcdwitxy 116 10 this this DT cord-275041-fcdwitxy 116 11 study study NN cord-275041-fcdwitxy 116 12 . . . cord-275041-fcdwitxy 117 1 The the DT cord-275041-fcdwitxy 117 2 positive positive JJ cord-275041-fcdwitxy 117 3 effect effect NN cord-275041-fcdwitxy 117 4 of of IN cord-275041-fcdwitxy 117 5 HCQ HCQ NNP cord-275041-fcdwitxy 117 6 seems seem VBZ cord-275041-fcdwitxy 117 7 consistent consistent JJ cord-275041-fcdwitxy 117 8 and and CC cord-275041-fcdwitxy 117 9 its -PRON- PRP$ cord-275041-fcdwitxy 117 10 use use NN cord-275041-fcdwitxy 117 11 could could MD cord-275041-fcdwitxy 117 12 be be VB cord-275041-fcdwitxy 117 13 considered consider VBN cord-275041-fcdwitxy 117 14 in in IN cord-275041-fcdwitxy 117 15 clinical clinical JJ cord-275041-fcdwitxy 117 16 settings setting NNS cord-275041-fcdwitxy 117 17 . . . cord-275041-fcdwitxy 118 1 HCQ HCQ NNP cord-275041-fcdwitxy 118 2 is be VBZ cord-275041-fcdwitxy 118 3 easy easy JJ cord-275041-fcdwitxy 118 4 to to TO cord-275041-fcdwitxy 118 5 administer administer VB cord-275041-fcdwitxy 118 6 , , , cord-275041-fcdwitxy 118 7 and and CC cord-275041-fcdwitxy 118 8 its -PRON- PRP$ cord-275041-fcdwitxy 118 9 use use NN cord-275041-fcdwitxy 118 10 in in IN cord-275041-fcdwitxy 118 11 ambulatory ambulatory JJ cord-275041-fcdwitxy 118 12 patients patient NNS cord-275041-fcdwitxy 118 13 , , , cord-275041-fcdwitxy 118 14 to to TO cord-275041-fcdwitxy 118 15 reduce reduce VB cord-275041-fcdwitxy 118 16 symptoms symptom NNS cord-275041-fcdwitxy 118 17 , , , cord-275041-fcdwitxy 118 18 prevent prevent VB cord-275041-fcdwitxy 118 19 admissions admission NNS cord-275041-fcdwitxy 118 20 , , , cord-275041-fcdwitxy 118 21 decrease decrease VB cord-275041-fcdwitxy 118 22 mortality mortality NN cord-275041-fcdwitxy 118 23 , , , cord-275041-fcdwitxy 118 24 and and CC cord-275041-fcdwitxy 118 25 the the DT cord-275041-fcdwitxy 118 26 transmission transmission NN cord-275041-fcdwitxy 118 27 of of IN cord-275041-fcdwitxy 118 28 the the DT cord-275041-fcdwitxy 118 29 disease disease NN cord-275041-fcdwitxy 118 30 , , , cord-275041-fcdwitxy 118 31 could could MD cord-275041-fcdwitxy 118 32 also also RB cord-275041-fcdwitxy 118 33 be be VB cord-275041-fcdwitxy 118 34 considered consider VBN cord-275041-fcdwitxy 118 35 by by IN cord-275041-fcdwitxy 118 36 clinicians clinician NNS cord-275041-fcdwitxy 118 37 and and CC cord-275041-fcdwitxy 118 38 future future JJ cord-275041-fcdwitxy 118 39 researchers researcher NNS cord-275041-fcdwitxy 118 40 . . . cord-275041-fcdwitxy 118 41 _SP cord-275041-fcdwitxy 119 1 The the DT cord-275041-fcdwitxy 119 2 author(s author(s NNP cord-275041-fcdwitxy 119 3 ) ) -RRB- cord-275041-fcdwitxy 119 4 declare declare VBP cord-275041-fcdwitxy 119 5 that that IN cord-275041-fcdwitxy 119 6 they -PRON- PRP cord-275041-fcdwitxy 119 7 have have VBP cord-275041-fcdwitxy 119 8 no no DT cord-275041-fcdwitxy 119 9 conflict conflict NN cord-275041-fcdwitxy 119 10 of of IN cord-275041-fcdwitxy 119 11 interest interest NN cord-275041-fcdwitxy 119 12 . . . cord-275041-fcdwitxy 120 1 The the DT cord-275041-fcdwitxy 120 2 ethics ethic NNS cord-275041-fcdwitxy 120 3 committee committee NN cord-275041-fcdwitxy 120 4 of of IN cord-275041-fcdwitxy 120 5 HM HM NNP cord-275041-fcdwitxy 120 6 Hospitales Hospitales NNP cord-275041-fcdwitxy 120 7 approved approve VBD cord-275041-fcdwitxy 120 8 this this DT cord-275041-fcdwitxy 120 9 study study NN cord-275041-fcdwitxy 120 10 . . . cord-275041-fcdwitxy 121 1 Data datum NNS cord-275041-fcdwitxy 121 2 were be VBD cord-275041-fcdwitxy 121 3 anonymized anonymize VBN cord-275041-fcdwitxy 121 4 before before IN cord-275041-fcdwitxy 121 5 the the DT cord-275041-fcdwitxy 121 6 authors author NNS cord-275041-fcdwitxy 121 7 could could MD cord-275041-fcdwitxy 121 8 access access VB cord-275041-fcdwitxy 121 9 it -PRON- PRP cord-275041-fcdwitxy 121 10 . . . cord-275041-fcdwitxy 122 1 No no DT cord-275041-fcdwitxy 122 2 results result NNS cord-275041-fcdwitxy 122 3 that that WDT cord-275041-fcdwitxy 122 4 may may MD cord-275041-fcdwitxy 122 5 make make VB cord-275041-fcdwitxy 122 6 patients patient NNS cord-275041-fcdwitxy 122 7 identifiable identifiable JJ cord-275041-fcdwitxy 122 8 are be VBP cord-275041-fcdwitxy 122 9 reported report VBN cord-275041-fcdwitxy 122 10 . . . cord-275041-fcdwitxy 123 1 The the DT cord-275041-fcdwitxy 123 2 study study NN cord-275041-fcdwitxy 123 3 was be VBD cord-275041-fcdwitxy 123 4 conducted conduct VBN cord-275041-fcdwitxy 123 5 in in IN cord-275041-fcdwitxy 123 6 accordance accordance NN cord-275041-fcdwitxy 123 7 with with IN cord-275041-fcdwitxy 123 8 the the DT cord-275041-fcdwitxy 123 9 ethical ethical JJ cord-275041-fcdwitxy 123 10 standards standard NNS cord-275041-fcdwitxy 123 11 as as IN cord-275041-fcdwitxy 123 12 laid lay VBN cord-275041-fcdwitxy 123 13 down down RP cord-275041-fcdwitxy 123 14 in in IN cord-275041-fcdwitxy 123 15 the the DT cord-275041-fcdwitxy 123 16 1964 1964 CD cord-275041-fcdwitxy 123 17 Declaration Declaration NNP cord-275041-fcdwitxy 123 18 of of IN cord-275041-fcdwitxy 123 19 Helsinki Helsinki NNP cord-275041-fcdwitxy 123 20 and and CC cord-275041-fcdwitxy 123 21 its -PRON- PRP$ cord-275041-fcdwitxy 123 22 later later JJ cord-275041-fcdwitxy 123 23 amendments amendment NNS cord-275041-fcdwitxy 123 24 . . . cord-275041-fcdwitxy 124 1 Informed informed JJ cord-275041-fcdwitxy 124 2 consent consent NN cord-275041-fcdwitxy 125 1 This this DT cord-275041-fcdwitxy 125 2 study study NN cord-275041-fcdwitxy 125 3 was be VBD cord-275041-fcdwitxy 125 4 conducted conduct VBN cord-275041-fcdwitxy 125 5 on on IN cord-275041-fcdwitxy 125 6 already already RB cord-275041-fcdwitxy 125 7 available available JJ cord-275041-fcdwitxy 125 8 clincal clincal JJ cord-275041-fcdwitxy 125 9 data datum NNS cord-275041-fcdwitxy 125 10 and and CC cord-275041-fcdwitxy 125 11 informed informed JJ cord-275041-fcdwitxy 125 12 consent consent NN cord-275041-fcdwitxy 125 13 was be VBD cord-275041-fcdwitxy 125 14 not not RB cord-275041-fcdwitxy 125 15 required require VBN cord-275041-fcdwitxy 125 16 . . . cord-275041-fcdwitxy 126 1 Open open VB cord-275041-fcdwitxy 126 2 Access Access NNP cord-275041-fcdwitxy 127 1 This this DT cord-275041-fcdwitxy 127 2 article article NN cord-275041-fcdwitxy 127 3 is be VBZ cord-275041-fcdwitxy 127 4 licensed license VBN cord-275041-fcdwitxy 127 5 under under IN cord-275041-fcdwitxy 127 6 a a DT cord-275041-fcdwitxy 127 7 Creative Creative NNP cord-275041-fcdwitxy 127 8 Commons Commons NNP cord-275041-fcdwitxy 127 9 Attribution Attribution NNP cord-275041-fcdwitxy 127 10 4.0 4.0 CD cord-275041-fcdwitxy 127 11 International International NNP cord-275041-fcdwitxy 127 12 License License NNP cord-275041-fcdwitxy 127 13 , , , cord-275041-fcdwitxy 127 14 which which WDT cord-275041-fcdwitxy 127 15 permits permit VBZ cord-275041-fcdwitxy 127 16 use use NN cord-275041-fcdwitxy 127 17 , , , cord-275041-fcdwitxy 127 18 sharing sharing NN cord-275041-fcdwitxy 127 19 , , , cord-275041-fcdwitxy 127 20 adaptation adaptation NN cord-275041-fcdwitxy 127 21 , , , cord-275041-fcdwitxy 127 22 distribution distribution NN cord-275041-fcdwitxy 127 23 and and CC cord-275041-fcdwitxy 127 24 reproduction reproduction NN cord-275041-fcdwitxy 127 25 in in IN cord-275041-fcdwitxy 127 26 any any DT cord-275041-fcdwitxy 127 27 medium medium NN cord-275041-fcdwitxy 127 28 or or CC cord-275041-fcdwitxy 127 29 format format NN cord-275041-fcdwitxy 127 30 , , , cord-275041-fcdwitxy 127 31 as as RB cord-275041-fcdwitxy 127 32 long long RB cord-275041-fcdwitxy 127 33 as as IN cord-275041-fcdwitxy 127 34 you -PRON- PRP cord-275041-fcdwitxy 127 35 give give VBP cord-275041-fcdwitxy 127 36 appropriate appropriate JJ cord-275041-fcdwitxy 127 37 credit credit NN cord-275041-fcdwitxy 127 38 to to IN cord-275041-fcdwitxy 127 39 the the DT cord-275041-fcdwitxy 127 40 original original JJ cord-275041-fcdwitxy 127 41 author(s author(s NNP cord-275041-fcdwitxy 127 42 ) ) -RRB- cord-275041-fcdwitxy 127 43 and and CC cord-275041-fcdwitxy 127 44 the the DT cord-275041-fcdwitxy 127 45 source source NN cord-275041-fcdwitxy 127 46 , , , cord-275041-fcdwitxy 127 47 provide provide VB cord-275041-fcdwitxy 127 48 a a DT cord-275041-fcdwitxy 127 49 link link NN cord-275041-fcdwitxy 127 50 to to IN cord-275041-fcdwitxy 127 51 the the DT cord-275041-fcdwitxy 127 52 Creative Creative NNP cord-275041-fcdwitxy 127 53 Commons Commons NNP cord-275041-fcdwitxy 127 54 licence licence NN cord-275041-fcdwitxy 127 55 , , , cord-275041-fcdwitxy 127 56 and and CC cord-275041-fcdwitxy 127 57 indicate indicate VBP cord-275041-fcdwitxy 127 58 if if IN cord-275041-fcdwitxy 127 59 changes change NNS cord-275041-fcdwitxy 127 60 were be VBD cord-275041-fcdwitxy 127 61 made make VBN cord-275041-fcdwitxy 127 62 . . . cord-275041-fcdwitxy 128 1 The the DT cord-275041-fcdwitxy 128 2 images image NNS cord-275041-fcdwitxy 128 3 or or CC cord-275041-fcdwitxy 128 4 other other JJ cord-275041-fcdwitxy 128 5 third third JJ cord-275041-fcdwitxy 128 6 party party NN cord-275041-fcdwitxy 128 7 material material NN cord-275041-fcdwitxy 128 8 in in IN cord-275041-fcdwitxy 128 9 this this DT cord-275041-fcdwitxy 128 10 article article NN cord-275041-fcdwitxy 128 11 are be VBP cord-275041-fcdwitxy 128 12 included include VBN cord-275041-fcdwitxy 128 13 in in IN cord-275041-fcdwitxy 128 14 the the DT cord-275041-fcdwitxy 128 15 article article NN cord-275041-fcdwitxy 128 16 's 's POS cord-275041-fcdwitxy 128 17 Creative Creative NNP cord-275041-fcdwitxy 128 18 Commons Commons NNP cord-275041-fcdwitxy 128 19 licence licence NN cord-275041-fcdwitxy 128 20 , , , cord-275041-fcdwitxy 128 21 unless unless IN cord-275041-fcdwitxy 128 22 indicated indicate VBN cord-275041-fcdwitxy 128 23 otherwise otherwise RB cord-275041-fcdwitxy 128 24 in in IN cord-275041-fcdwitxy 128 25 a a DT cord-275041-fcdwitxy 128 26 credit credit NN cord-275041-fcdwitxy 128 27 line line NN cord-275041-fcdwitxy 128 28 to to IN cord-275041-fcdwitxy 128 29 the the DT cord-275041-fcdwitxy 128 30 material material NN cord-275041-fcdwitxy 128 31 . . . cord-275041-fcdwitxy 129 1 If if IN cord-275041-fcdwitxy 129 2 material material NN cord-275041-fcdwitxy 129 3 is be VBZ cord-275041-fcdwitxy 129 4 not not RB cord-275041-fcdwitxy 129 5 included include VBN cord-275041-fcdwitxy 129 6 in in IN cord-275041-fcdwitxy 129 7 the the DT cord-275041-fcdwitxy 129 8 article article NN cord-275041-fcdwitxy 129 9 's 's POS cord-275041-fcdwitxy 129 10 Creative Creative NNP cord-275041-fcdwitxy 129 11 Commons Commons NNP cord-275041-fcdwitxy 129 12 licence licence NN cord-275041-fcdwitxy 129 13 and and CC cord-275041-fcdwitxy 129 14 your -PRON- PRP$ cord-275041-fcdwitxy 129 15 intended intend VBN cord-275041-fcdwitxy 129 16 use use NN cord-275041-fcdwitxy 129 17 is be VBZ cord-275041-fcdwitxy 129 18 not not RB cord-275041-fcdwitxy 129 19 permitted permit VBN cord-275041-fcdwitxy 129 20 by by IN cord-275041-fcdwitxy 129 21 statutory statutory JJ cord-275041-fcdwitxy 129 22 regulation regulation NN cord-275041-fcdwitxy 129 23 or or CC cord-275041-fcdwitxy 129 24 exceeds exceed VBZ cord-275041-fcdwitxy 129 25 the the DT cord-275041-fcdwitxy 129 26 permitted permit VBN cord-275041-fcdwitxy 129 27 use use NN cord-275041-fcdwitxy 129 28 , , , cord-275041-fcdwitxy 129 29 you -PRON- PRP cord-275041-fcdwitxy 129 30 will will MD cord-275041-fcdwitxy 129 31 need need VB cord-275041-fcdwitxy 129 32 to to TO cord-275041-fcdwitxy 129 33 obtain obtain VB cord-275041-fcdwitxy 129 34 permission permission NN cord-275041-fcdwitxy 129 35 directly directly RB cord-275041-fcdwitxy 129 36 from from IN cord-275041-fcdwitxy 129 37 the the DT cord-275041-fcdwitxy 129 38 copyright copyright NN cord-275041-fcdwitxy 129 39 holder holder NN cord-275041-fcdwitxy 129 40 . . . cord-275041-fcdwitxy 130 1 To to TO cord-275041-fcdwitxy 130 2 view view VB cord-275041-fcdwitxy 130 3 a a DT cord-275041-fcdwitxy 130 4 copy copy NN cord-275041-fcdwitxy 130 5 of of IN cord-275041-fcdwitxy 130 6 this this DT cord-275041-fcdwitxy 130 7 licence licence NN cord-275041-fcdwitxy 130 8 , , , cord-275041-fcdwitxy 130 9 visit visit VB cord-275041-fcdwitxy 130 10 http://creat http://creat NNP cord-275041-fcdwitxy 130 11 iveco iveco NNP cord-275041-fcdwitxy 130 12 mmons mmons NNP cord-275041-fcdwitxy 130 13 .org .org . cord-275041-fcdwitxy 131 1 / / NFP cord-275041-fcdwitxy 132 1 licen licen NNP cord-275041-fcdwitxy 133 1 ses ses NNP cord-275041-fcdwitxy 133 2 / / SYM cord-275041-fcdwitxy 133 3 by/4.0/. by/4.0/. NNP cord-275041-fcdwitxy 134 1 namin namin NNP cord-275041-fcdwitxy 134 2 g g NNP cord-275041-fcdwitxy 134 3 - - HYPH cord-275041-fcdwitxy 134 4 thecoron thecoron NNP cord-275041-fcdwitxy 134 5 aviru aviru NNP cord-275041-fcdwitxy 134 6 s s POS cord-275041-fcdwitxy 134 7 - - HYPH cord-275041-fcdwitxy 134 8 disea disea NNP cord-275041-fcdwitxy 134 9 se-(covid se-(covid . cord-275041-fcdwitxy 135 1 -2019)-and -2019)-and VB cord-275041-fcdwitxy 135 2 - - HYPH cord-275041-fcdwitxy 135 3 the the DT cord-275041-fcdwitxy 135 4 - - HYPH cord-275041-fcdwitxy 135 5 virus virus NN cord-275041-fcdwitxy 135 6 -that -that NN cord-275041-fcdwitxy 135 7 - - : cord-275041-fcdwitxy 135 8 cause cause NN cord-275041-fcdwitxy 135 9 s s NN cord-275041-fcdwitxy 135 10 - - : cord-275041-fcdwitxy 135 11 it -PRON- PRP cord-275041-fcdwitxy 136 1 WHO who WP cord-275041-fcdwitxy 136 2 ( ( -LRB- cord-275041-fcdwitxy 136 3 2020 2020 CD cord-275041-fcdwitxy 136 4 ) ) -RRB- cord-275041-fcdwitxy 137 1 Coronavirus Coronavirus NNP cord-275041-fcdwitxy 137 2 disease disease NN cord-275041-fcdwitxy 137 3 ( ( -LRB- cord-275041-fcdwitxy 138 1 COVID-19 covid-19 LS cord-275041-fcdwitxy 138 2 ) ) -RRB- cord-275041-fcdwitxy 138 3 Pandemic Pandemic NNP cord-275041-fcdwitxy 138 4 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 138 5 CORONAVIRUS CORONAVIRUS NNP cord-275041-fcdwitxy 138 6 PANDEMIC pandemic NN cord-275041-fcdwitxy 138 7 Estimating estimate VBG cord-275041-fcdwitxy 138 8 clinical clinical JJ cord-275041-fcdwitxy 138 9 severity severity NN cord-275041-fcdwitxy 138 10 of of IN cord-275041-fcdwitxy 138 11 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 138 12 from from IN cord-275041-fcdwitxy 138 13 the the DT cord-275041-fcdwitxy 138 14 transmission transmission NN cord-275041-fcdwitxy 138 15 dynamics dynamic NNS cord-275041-fcdwitxy 138 16 in in IN cord-275041-fcdwitxy 138 17 Wuhan Wuhan NNP cord-275041-fcdwitxy 138 18 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 138 19 : : : cord-275041-fcdwitxy 138 20 learning learn VBG cord-275041-fcdwitxy 138 21 from from IN cord-275041-fcdwitxy 138 22 experience experience NN cord-275041-fcdwitxy 138 23 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 138 24 : : : cord-275041-fcdwitxy 138 25 risk risk NN cord-275041-fcdwitxy 138 26 of of IN cord-275041-fcdwitxy 138 27 second second JJ cord-275041-fcdwitxy 138 28 wave wave NN cord-275041-fcdwitxy 138 29 is be VBZ cord-275041-fcdwitxy 138 30 very very RB cord-275041-fcdwitxy 138 31 real real JJ cord-275041-fcdwitxy 138 32 , , , cord-275041-fcdwitxy 138 33 say say VBP cord-275041-fcdwitxy 138 34 researchers researcher NNS cord-275041-fcdwitxy 138 35 First first JJ cord-275041-fcdwitxy 138 36 - - HYPH cord-275041-fcdwitxy 138 37 wave wave NN cord-275041-fcdwitxy 138 38 COVID-19 covid-19 JJ cord-275041-fcdwitxy 138 39 transmissibility transmissibility NN cord-275041-fcdwitxy 138 40 and and CC cord-275041-fcdwitxy 138 41 severity severity NN cord-275041-fcdwitxy 138 42 in in IN cord-275041-fcdwitxy 138 43 China China NNP cord-275041-fcdwitxy 138 44 outside outside IN cord-275041-fcdwitxy 138 45 Hubei Hubei NNP cord-275041-fcdwitxy 138 46 after after IN cord-275041-fcdwitxy 138 47 control control NN cord-275041-fcdwitxy 138 48 measures measure NNS cord-275041-fcdwitxy 138 49 , , , cord-275041-fcdwitxy 138 50 and and CC cord-275041-fcdwitxy 138 51 second second JJ cord-275041-fcdwitxy 138 52 - - HYPH cord-275041-fcdwitxy 138 53 wave wave NN cord-275041-fcdwitxy 138 54 scenario scenario NN cord-275041-fcdwitxy 138 55 planning planning NN cord-275041-fcdwitxy 138 56 : : : cord-275041-fcdwitxy 138 57 a a DT cord-275041-fcdwitxy 138 58 modelling modelling NN cord-275041-fcdwitxy 138 59 impact impact NN cord-275041-fcdwitxy 138 60 assessment assessment NN cord-275041-fcdwitxy 139 1 The the DT cord-275041-fcdwitxy 139 2 global global JJ cord-275041-fcdwitxy 139 3 impact impact NN cord-275041-fcdwitxy 139 4 of of IN cord-275041-fcdwitxy 139 5 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 139 6 and and CC cord-275041-fcdwitxy 139 7 strategies strategy NNS cord-275041-fcdwitxy 139 8 for for IN cord-275041-fcdwitxy 139 9 mitigation mitigation NN cord-275041-fcdwitxy 139 10 and and CC cord-275041-fcdwitxy 139 11 suppression suppression NN cord-275041-fcdwitxy 139 12 Clinical clinical JJ cord-275041-fcdwitxy 139 13 and and CC cord-275041-fcdwitxy 139 14 microbiological microbiological JJ cord-275041-fcdwitxy 139 15 effect effect NN cord-275041-fcdwitxy 139 16 of of IN cord-275041-fcdwitxy 139 17 a a DT cord-275041-fcdwitxy 139 18 combination combination NN cord-275041-fcdwitxy 139 19 of of IN cord-275041-fcdwitxy 139 20 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 139 21 and and CC cord-275041-fcdwitxy 139 22 azithromycin azithromycin NNP cord-275041-fcdwitxy 139 23 in in IN cord-275041-fcdwitxy 139 24 80 80 CD cord-275041-fcdwitxy 139 25 COVID-19 covid-19 JJ cord-275041-fcdwitxy 139 26 patients patient NNS cord-275041-fcdwitxy 139 27 with with IN cord-275041-fcdwitxy 139 28 at at RB cord-275041-fcdwitxy 139 29 least least JJS cord-275041-fcdwitxy 139 30 a a DT cord-275041-fcdwitxy 139 31 six six CD cord-275041-fcdwitxy 139 32 - - HYPH cord-275041-fcdwitxy 139 33 day day NN cord-275041-fcdwitxy 139 34 follow follow VB cord-275041-fcdwitxy 139 35 up up RP cord-275041-fcdwitxy 139 36 : : : cord-275041-fcdwitxy 139 37 a a DT cord-275041-fcdwitxy 139 38 pilot pilot NN cord-275041-fcdwitxy 139 39 observational observational JJ cord-275041-fcdwitxy 139 40 study study NN cord-275041-fcdwitxy 139 41 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 139 42 and and CC cord-275041-fcdwitxy 139 43 azithromycin azithromycin NNP cord-275041-fcdwitxy 139 44 as as IN cord-275041-fcdwitxy 139 45 a a DT cord-275041-fcdwitxy 139 46 treatment treatment NN cord-275041-fcdwitxy 139 47 of of IN cord-275041-fcdwitxy 139 48 COVID-19 covid-19 NN cord-275041-fcdwitxy 139 49 : : : cord-275041-fcdwitxy 139 50 results result NNS cord-275041-fcdwitxy 139 51 of of IN cord-275041-fcdwitxy 139 52 an an DT cord-275041-fcdwitxy 139 53 open open JJ cord-275041-fcdwitxy 139 54 - - HYPH cord-275041-fcdwitxy 139 55 label label NN cord-275041-fcdwitxy 139 56 non non JJ cord-275041-fcdwitxy 139 57 - - JJ cord-275041-fcdwitxy 139 58 randomized randomized JJ cord-275041-fcdwitxy 139 59 clinical clinical JJ cord-275041-fcdwitxy 139 60 trial trial NN cord-275041-fcdwitxy 139 61 Design design NN cord-275041-fcdwitxy 139 62 and and CC cord-275041-fcdwitxy 139 63 synthesis synthesis NN cord-275041-fcdwitxy 139 64 of of IN cord-275041-fcdwitxy 139 65 hydroxyferroquine hydroxyferroquine NNP cord-275041-fcdwitxy 139 66 derivatives derivative NNS cord-275041-fcdwitxy 139 67 with with IN cord-275041-fcdwitxy 139 68 antimalarial antimalarial JJ cord-275041-fcdwitxy 139 69 and and CC cord-275041-fcdwitxy 139 70 antiviral antiviral JJ cord-275041-fcdwitxy 139 71 activities activity NNS cord-275041-fcdwitxy 140 1 Structural structural JJ cord-275041-fcdwitxy 140 2 and and CC cord-275041-fcdwitxy 140 3 molecular molecular JJ cord-275041-fcdwitxy 140 4 modelling modelling NN cord-275041-fcdwitxy 140 5 studies study NNS cord-275041-fcdwitxy 140 6 reveal reveal VBP cord-275041-fcdwitxy 140 7 a a DT cord-275041-fcdwitxy 140 8 new new JJ cord-275041-fcdwitxy 140 9 mechanism mechanism NN cord-275041-fcdwitxy 140 10 of of IN cord-275041-fcdwitxy 140 11 action action NN cord-275041-fcdwitxy 140 12 of of IN cord-275041-fcdwitxy 140 13 chloroquine chloroquine NNP cord-275041-fcdwitxy 140 14 and and CC cord-275041-fcdwitxy 140 15 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 140 16 against against IN cord-275041-fcdwitxy 140 17 SARS SARS NNP cord-275041-fcdwitxy 140 18 - - HYPH cord-275041-fcdwitxy 140 19 CoV-2 CoV-2 NNP cord-275041-fcdwitxy 140 20 infection infection NN cord-275041-fcdwitxy 140 21 Should Should MD cord-275041-fcdwitxy 140 22 chloroquine chloroquine VB cord-275041-fcdwitxy 140 23 and and CC cord-275041-fcdwitxy 140 24 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 140 25 be be VB cord-275041-fcdwitxy 140 26 used use VBN cord-275041-fcdwitxy 140 27 to to TO cord-275041-fcdwitxy 140 28 treat treat VB cord-275041-fcdwitxy 140 29 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 140 30 . . . cord-275041-fcdwitxy 141 1 A a DT cord-275041-fcdwitxy 141 2 rapid rapid JJ cord-275041-fcdwitxy 141 3 review review NN cord-275041-fcdwitxy 141 4 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 141 5 , , , cord-275041-fcdwitxy 141 6 a a DT cord-275041-fcdwitxy 141 7 less less RBR cord-275041-fcdwitxy 141 8 toxic toxic JJ cord-275041-fcdwitxy 141 9 derivative derivative NN cord-275041-fcdwitxy 141 10 of of IN cord-275041-fcdwitxy 141 11 chloroquine chloroquine NN cord-275041-fcdwitxy 141 12 , , , cord-275041-fcdwitxy 141 13 is be VBZ cord-275041-fcdwitxy 141 14 effective effective JJ cord-275041-fcdwitxy 141 15 in in IN cord-275041-fcdwitxy 141 16 inhibiting inhibit VBG cord-275041-fcdwitxy 141 17 SARS SARS NNP cord-275041-fcdwitxy 141 18 - - HYPH cord-275041-fcdwitxy 141 19 CoV-2 CoV-2 NNP cord-275041-fcdwitxy 141 20 infection infection NN cord-275041-fcdwitxy 141 21 in in IN cord-275041-fcdwitxy 141 22 vitro vitro FW cord-275041-fcdwitxy 141 23 WHO who WP cord-275041-fcdwitxy 141 24 ( ( -LRB- cord-275041-fcdwitxy 141 25 2020 2020 CD cord-275041-fcdwitxy 141 26 ) ) -RRB- cord-275041-fcdwitxy 142 1 WHO who WP cord-275041-fcdwitxy 142 2 discontinues discontinue VBZ cord-275041-fcdwitxy 142 3 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 142 4 and and CC cord-275041-fcdwitxy 142 5 lopinavir lopinavir NNP cord-275041-fcdwitxy 142 6 / / SYM cord-275041-fcdwitxy 142 7 ritonavir ritonavir NNP cord-275041-fcdwitxy 142 8 treatment treatment NN cord-275041-fcdwitxy 142 9 arms arm NNS cord-275041-fcdwitxy 142 10 for for IN cord-275041-fcdwitxy 142 11 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 142 12 Solidarity Solidarity NNP cord-275041-fcdwitxy 142 13 " " '' cord-275041-fcdwitxy 142 14 clinical clinical JJ cord-275041-fcdwitxy 142 15 trial trial NN cord-275041-fcdwitxy 142 16 for for IN cord-275041-fcdwitxy 142 17 COVID-19 covid-19 JJ cord-275041-fcdwitxy 142 18 treatments treatment NNS cord-275041-fcdwitxy 142 19 Acccessed Acccessed NNP cord-275041-fcdwitxy 142 20 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 142 21 and and CC cord-275041-fcdwitxy 142 22 Azithromycin Azithromycin NNP cord-275041-fcdwitxy 142 23 as as IN cord-275041-fcdwitxy 142 24 a a DT cord-275041-fcdwitxy 142 25 Treatment Treatment NNP cord-275041-fcdwitxy 142 26 of of IN cord-275041-fcdwitxy 142 27 COVID-19 covid-19 NN cord-275041-fcdwitxy 142 28 : : : cord-275041-fcdwitxy 142 29 Results result NNS cord-275041-fcdwitxy 142 30 of of IN cord-275041-fcdwitxy 142 31 an an DT cord-275041-fcdwitxy 142 32 2 2 CD cord-275041-fcdwitxy 142 33 Open Open NNP cord-275041-fcdwitxy 142 34 - - HYPH cord-275041-fcdwitxy 142 35 Label Label NNP cord-275041-fcdwitxy 142 36 Non Non NNP cord-275041-fcdwitxy 142 37 - - NNP cord-275041-fcdwitxy 142 38 Randomized Randomized NNP cord-275041-fcdwitxy 142 39 Clinical Clinical NNP cord-275041-fcdwitxy 142 40 Trial Trial NNP cord-275041-fcdwitxy 142 41 : : : cord-275041-fcdwitxy 142 42 Response response NN cord-275041-fcdwitxy 142 43 to to IN cord-275041-fcdwitxy 142 44 David David NNP cord-275041-fcdwitxy 142 45 Spencer Spencer NNP cord-275041-fcdwitxy 143 1 Low low JJ cord-275041-fcdwitxy 143 2 dose dose NN cord-275041-fcdwitxy 143 3 of of IN cord-275041-fcdwitxy 143 4 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 143 5 reduces reduce VBZ cord-275041-fcdwitxy 143 6 fatality fatality NN cord-275041-fcdwitxy 143 7 of of IN cord-275041-fcdwitxy 143 8 critically critically RB cord-275041-fcdwitxy 143 9 ill ill JJ cord-275041-fcdwitxy 143 10 patients patient NNS cord-275041-fcdwitxy 143 11 with with IN cord-275041-fcdwitxy 143 12 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 143 13 Outcomes Outcomes NNPS cord-275041-fcdwitxy 143 14 of of IN cord-275041-fcdwitxy 143 15 3737 3737 CD cord-275041-fcdwitxy 144 1 COVID-19 covid-19 JJ cord-275041-fcdwitxy 144 2 patients patient NNS cord-275041-fcdwitxy 144 3 treated treat VBN cord-275041-fcdwitxy 144 4 with with IN cord-275041-fcdwitxy 144 5 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 144 6 / / SYM cord-275041-fcdwitxy 144 7 azithromycin azithromycin NNP cord-275041-fcdwitxy 144 8 and and CC cord-275041-fcdwitxy 144 9 other other JJ cord-275041-fcdwitxy 144 10 regimens regimen NNS cord-275041-fcdwitxy 144 11 in in IN cord-275041-fcdwitxy 144 12 Marseille Marseille NNP cord-275041-fcdwitxy 144 13 , , , cord-275041-fcdwitxy 144 14 France France NNP cord-275041-fcdwitxy 144 15 : : : cord-275041-fcdwitxy 145 1 a a DT cord-275041-fcdwitxy 145 2 retrospective retrospective JJ cord-275041-fcdwitxy 145 3 analysis analysis NN cord-275041-fcdwitxy 145 4 Treatment treatment NN cord-275041-fcdwitxy 145 5 with with IN cord-275041-fcdwitxy 145 6 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 145 7 , , , cord-275041-fcdwitxy 145 8 azithromycin azithromycin NNP cord-275041-fcdwitxy 145 9 , , , cord-275041-fcdwitxy 145 10 and and CC cord-275041-fcdwitxy 145 11 combination combination NN cord-275041-fcdwitxy 145 12 in in IN cord-275041-fcdwitxy 145 13 patients patient NNS cord-275041-fcdwitxy 145 14 hospitalized hospitalize VBN cord-275041-fcdwitxy 145 15 with with IN cord-275041-fcdwitxy 145 16 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 145 17 Early Early NNP cord-275041-fcdwitxy 145 18 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 145 19 Is be VBZ cord-275041-fcdwitxy 145 20 Associated associate VBN cord-275041-fcdwitxy 145 21 with with IN cord-275041-fcdwitxy 145 22 an an DT cord-275041-fcdwitxy 145 23 Increase increase NN cord-275041-fcdwitxy 145 24 of of IN cord-275041-fcdwitxy 145 25 Survival Survival NNP cord-275041-fcdwitxy 145 26 in in IN cord-275041-fcdwitxy 145 27 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 145 28 Patients patient NNS cord-275041-fcdwitxy 145 29 : : : cord-275041-fcdwitxy 146 1 An an DT cord-275041-fcdwitxy 146 2 Observational Observational NNP cord-275041-fcdwitxy 146 3 Study Study NNP cord-275041-fcdwitxy 146 4 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 146 5 Outpatients Outpatients NNP cord-275041-fcdwitxy 146 6 - - HYPH cord-275041-fcdwitxy 146 7 early early JJ cord-275041-fcdwitxy 146 8 risk risk NN cord-275041-fcdwitxy 146 9 - - HYPH cord-275041-fcdwitxy 146 10 stratified stratify VBN cord-275041-fcdwitxy 146 11 treatment treatment NN cord-275041-fcdwitxy 146 12 with with IN cord-275041-fcdwitxy 146 13 zinc zinc NN cord-275041-fcdwitxy 146 14 plus plus CC cord-275041-fcdwitxy 146 15 low low JJ cord-275041-fcdwitxy 146 16 dose dose NN cord-275041-fcdwitxy 146 17 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 146 18 and and CC cord-275041-fcdwitxy 146 19 azithromycin azithromycin NNP cord-275041-fcdwitxy 146 20 : : : cord-275041-fcdwitxy 146 21 a a DT cord-275041-fcdwitxy 146 22 retrospective retrospective JJ cord-275041-fcdwitxy 146 23 case case NN cord-275041-fcdwitxy 146 24 series series NN cord-275041-fcdwitxy 146 25 study study NN cord-275041-fcdwitxy 147 1 Azithromycin Azithromycin NNP cord-275041-fcdwitxy 147 2 and and CC cord-275041-fcdwitxy 147 3 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 147 4 accelerate accelerate VB cord-275041-fcdwitxy 147 5 recovery recovery NN cord-275041-fcdwitxy 147 6 of of IN cord-275041-fcdwitxy 147 7 outpatients outpatient NNS cord-275041-fcdwitxy 147 8 with with IN cord-275041-fcdwitxy 147 9 mild/ mild/ NNP cord-275041-fcdwitxy 147 10 moderate moderate JJ cord-275041-fcdwitxy 147 11 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 147 12 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 147 13 with with IN cord-275041-fcdwitxy 147 14 or or CC cord-275041-fcdwitxy 147 15 without without IN cord-275041-fcdwitxy 147 16 azithromycin azithromycin NN cord-275041-fcdwitxy 147 17 and and CC cord-275041-fcdwitxy 147 18 in in IN cord-275041-fcdwitxy 147 19 - - HYPH cord-275041-fcdwitxy 147 20 hospital hospital NN cord-275041-fcdwitxy 147 21 mortality mortality NN cord-275041-fcdwitxy 147 22 or or CC cord-275041-fcdwitxy 147 23 discharge discharge NN cord-275041-fcdwitxy 147 24 in in IN cord-275041-fcdwitxy 147 25 patients patient NNS cord-275041-fcdwitxy 147 26 hospitalized hospitalize VBN cord-275041-fcdwitxy 147 27 for for IN cord-275041-fcdwitxy 147 28 COVID-19 covid-19 JJ cord-275041-fcdwitxy 147 29 infection infection NN cord-275041-fcdwitxy 147 30 : : : cord-275041-fcdwitxy 147 31 a a DT cord-275041-fcdwitxy 147 32 cohort cohort NN cord-275041-fcdwitxy 147 33 study study NN cord-275041-fcdwitxy 147 34 of of IN cord-275041-fcdwitxy 147 35 4642 4642 CD cord-275041-fcdwitxy 147 36 in in IN cord-275041-fcdwitxy 147 37 - - HYPH cord-275041-fcdwitxy 147 38 patients patient NNS cord-275041-fcdwitxy 147 39 in in IN cord-275041-fcdwitxy 147 40 France France NNP cord-275041-fcdwitxy 147 41 Clinical Clinical NNP cord-275041-fcdwitxy 147 42 Efficacy Efficacy NNP cord-275041-fcdwitxy 147 43 of of IN cord-275041-fcdwitxy 147 44 Chloroquine Chloroquine NNP cord-275041-fcdwitxy 147 45 derivatives derivative NNS cord-275041-fcdwitxy 147 46 in in IN cord-275041-fcdwitxy 147 47 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 147 48 Infection Infection NNP cord-275041-fcdwitxy 147 49 : : : cord-275041-fcdwitxy 147 50 comparative comparative JJ cord-275041-fcdwitxy 147 51 meta meta JJ cord-275041-fcdwitxy 147 52 - - HYPH cord-275041-fcdwitxy 147 53 analysis analysis NN cord-275041-fcdwitxy 147 54 between between IN cord-275041-fcdwitxy 147 55 the the DT cord-275041-fcdwitxy 147 56 Big big JJ cord-275041-fcdwitxy 147 57 data datum NNS cord-275041-fcdwitxy 147 58 and and CC cord-275041-fcdwitxy 147 59 the the DT cord-275041-fcdwitxy 147 60 real real JJ cord-275041-fcdwitxy 147 61 world world NN cord-275041-fcdwitxy 147 62 Efficacy Efficacy NNP cord-275041-fcdwitxy 147 63 and and CC cord-275041-fcdwitxy 147 64 safety safety NN cord-275041-fcdwitxy 147 65 of of IN cord-275041-fcdwitxy 147 66 chloroquine chloroquine NNP cord-275041-fcdwitxy 147 67 or or CC cord-275041-fcdwitxy 147 68 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 147 69 in in IN cord-275041-fcdwitxy 147 70 moderate moderate JJ cord-275041-fcdwitxy 147 71 type type NN cord-275041-fcdwitxy 147 72 of of IN cord-275041-fcdwitxy 147 73 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 147 74 : : : cord-275041-fcdwitxy 147 75 a a DT cord-275041-fcdwitxy 147 76 prospective prospective JJ cord-275041-fcdwitxy 147 77 open open JJ cord-275041-fcdwitxy 147 78 - - HYPH cord-275041-fcdwitxy 147 79 label label NN cord-275041-fcdwitxy 147 80 randomized randomize VBN cord-275041-fcdwitxy 147 81 controlled control VBN cord-275041-fcdwitxy 147 82 study study NN cord-275041-fcdwitxy 147 83 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 147 84 and and CC cord-275041-fcdwitxy 147 85 Tocilizumab Tocilizumab NNP cord-275041-fcdwitxy 147 86 Therapy Therapy NNP cord-275041-fcdwitxy 147 87 in in IN cord-275041-fcdwitxy 147 88 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 148 1 Patientsan patientsan JJ cord-275041-fcdwitxy 148 2 observational observational JJ cord-275041-fcdwitxy 148 3 study study NN cord-275041-fcdwitxy 148 4 Clinical clinical JJ cord-275041-fcdwitxy 148 5 efficacy efficacy NN cord-275041-fcdwitxy 148 6 of of IN cord-275041-fcdwitxy 148 7 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 148 8 in in IN cord-275041-fcdwitxy 148 9 patients patient NNS cord-275041-fcdwitxy 148 10 with with IN cord-275041-fcdwitxy 148 11 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 148 12 pneumonia pneumonia NN cord-275041-fcdwitxy 148 13 who who WP cord-275041-fcdwitxy 148 14 require require VBP cord-275041-fcdwitxy 148 15 oxygen oxygen NN cord-275041-fcdwitxy 148 16 : : : cord-275041-fcdwitxy 148 17 observational observational JJ cord-275041-fcdwitxy 148 18 comparative comparative JJ cord-275041-fcdwitxy 148 19 study study NN cord-275041-fcdwitxy 148 20 using use VBG cord-275041-fcdwitxy 148 21 routine routine JJ cord-275041-fcdwitxy 148 22 care care NN cord-275041-fcdwitxy 148 23 data datum NNS cord-275041-fcdwitxy 148 24 Observational observational JJ cord-275041-fcdwitxy 148 25 study study NN cord-275041-fcdwitxy 148 26 of of IN cord-275041-fcdwitxy 148 27 hydroxychloroquine hydroxychloroquine NNP cord-275041-fcdwitxy 148 28 in in IN cord-275041-fcdwitxy 148 29 hospitalized hospitalize VBN cord-275041-fcdwitxy 148 30 patients patient NNS cord-275041-fcdwitxy 148 31 with with IN cord-275041-fcdwitxy 148 32 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 148 33 Association Association NNP cord-275041-fcdwitxy 148 34 of of IN cord-275041-fcdwitxy 148 35 treatment treatment NN cord-275041-fcdwitxy 148 36 with with IN cord-275041-fcdwitxy 148 37 hydroxychloroquine hydroxychloroquine NNP cord-275041-fcdwitxy 148 38 or or CC cord-275041-fcdwitxy 148 39 azithromycin azithromycin NN cord-275041-fcdwitxy 148 40 with with IN cord-275041-fcdwitxy 148 41 in in IN cord-275041-fcdwitxy 148 42 - - HYPH cord-275041-fcdwitxy 148 43 hospital hospital NN cord-275041-fcdwitxy 148 44 mortality mortality NN cord-275041-fcdwitxy 148 45 in in IN cord-275041-fcdwitxy 148 46 patients patient NNS cord-275041-fcdwitxy 148 47 with with IN cord-275041-fcdwitxy 148 48 COVID-19 covid-19 CD cord-275041-fcdwitxy 148 49 in in IN cord-275041-fcdwitxy 148 50 New New NNP cord-275041-fcdwitxy 148 51 York York NNP cord-275041-fcdwitxy 148 52 State State NNP cord-275041-fcdwitxy 148 53 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 148 54 in in IN cord-275041-fcdwitxy 148 55 nonhospitalized nonhospitalized JJ cord-275041-fcdwitxy 148 56 adults adult NNS cord-275041-fcdwitxy 148 57 with with IN cord-275041-fcdwitxy 148 58 early early JJ cord-275041-fcdwitxy 148 59 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 148 60 : : : cord-275041-fcdwitxy 148 61 a a DT cord-275041-fcdwitxy 148 62 randomized randomized JJ cord-275041-fcdwitxy 148 63 trial trial NN cord-275041-fcdwitxy 148 64 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 148 65 with with IN cord-275041-fcdwitxy 148 66 or or CC cord-275041-fcdwitxy 148 67 without without IN cord-275041-fcdwitxy 148 68 azithromycin azithromycin NN cord-275041-fcdwitxy 148 69 in in IN cord-275041-fcdwitxy 148 70 mild mild NN cord-275041-fcdwitxy 148 71 - - HYPH cord-275041-fcdwitxy 148 72 to to IN cord-275041-fcdwitxy 148 73 - - HYPH cord-275041-fcdwitxy 148 74 moderate moderate JJ cord-275041-fcdwitxy 148 75 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 148 76 Hydroxychloroquine Hydroxychloroquine NNP cord-275041-fcdwitxy 148 77 in in IN cord-275041-fcdwitxy 148 78 patients patient NNS cord-275041-fcdwitxy 148 79 with with IN cord-275041-fcdwitxy 148 80 mainly mainly RB cord-275041-fcdwitxy 148 81 mild mild JJ cord-275041-fcdwitxy 148 82 to to IN cord-275041-fcdwitxy 148 83 moderate moderate JJ cord-275041-fcdwitxy 148 84 coronavirus coronavirus NN cord-275041-fcdwitxy 148 85 disease disease NN cord-275041-fcdwitxy 148 86 2019 2019 CD cord-275041-fcdwitxy 148 87 : : : cord-275041-fcdwitxy 148 88 open open JJ cord-275041-fcdwitxy 148 89 label label NN cord-275041-fcdwitxy 148 90 , , , cord-275041-fcdwitxy 148 91 randomised randomised JJ cord-275041-fcdwitxy 148 92 controlled control VBN cord-275041-fcdwitxy 148 93 trial trial NN cord-275041-fcdwitxy 148 94 2020 2020 CD cord-275041-fcdwitxy 148 95 ) ) -RRB- cord-275041-fcdwitxy 149 1 A a DT cord-275041-fcdwitxy 149 2 randomized randomized JJ cord-275041-fcdwitxy 149 3 trial trial NN cord-275041-fcdwitxy 149 4 of of IN cord-275041-fcdwitxy 149 5 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 149 6 as as IN cord-275041-fcdwitxy 149 7 postexposure postexposure NN cord-275041-fcdwitxy 149 8 prophylaxis prophylaxis NN cord-275041-fcdwitxy 149 9 for for IN cord-275041-fcdwitxy 149 10 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 149 11 Race Race NNP cord-275041-fcdwitxy 149 12 , , , cord-275041-fcdwitxy 149 13 socioeconomic socioeconomic JJ cord-275041-fcdwitxy 149 14 deprivation deprivation NN cord-275041-fcdwitxy 149 15 , , , cord-275041-fcdwitxy 149 16 and and CC cord-275041-fcdwitxy 149 17 hospitalization hospitalization NN cord-275041-fcdwitxy 149 18 for for IN cord-275041-fcdwitxy 149 19 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 149 20 in in IN cord-275041-fcdwitxy 149 21 English english JJ cord-275041-fcdwitxy 149 22 participants participant NNS cord-275041-fcdwitxy 149 23 of of IN cord-275041-fcdwitxy 149 24 a a DT cord-275041-fcdwitxy 149 25 national national JJ cord-275041-fcdwitxy 149 26 biobank biobank NN cord-275041-fcdwitxy 149 27 Could Could MD cord-275041-fcdwitxy 149 28 chloroquine chloroquine VB cord-275041-fcdwitxy 149 29 /hydroxychloroquine /hydroxychloroquine , cord-275041-fcdwitxy 149 30 be be VB cord-275041-fcdwitxy 149 31 harmful harmful JJ cord-275041-fcdwitxy 149 32 in in IN cord-275041-fcdwitxy 149 33 Coronavirus Coronavirus NNP cord-275041-fcdwitxy 149 34 Disease Disease NNP cord-275041-fcdwitxy 149 35 2019 2019 CD cord-275041-fcdwitxy 149 36 ( ( -LRB- cord-275041-fcdwitxy 149 37 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 149 38 ) ) -RRB- cord-275041-fcdwitxy 149 39 treatment treatment NN cord-275041-fcdwitxy 149 40 ? ? . cord-275041-fcdwitxy 150 1 QT qt NN cord-275041-fcdwitxy 150 2 interval interval NN cord-275041-fcdwitxy 150 3 prolongation prolongation NN cord-275041-fcdwitxy 150 4 and and CC cord-275041-fcdwitxy 150 5 torsade torsade NNP cord-275041-fcdwitxy 150 6 de de FW cord-275041-fcdwitxy 150 7 pointes pointes FW cord-275041-fcdwitxy 150 8 in in IN cord-275041-fcdwitxy 150 9 patients patient NNS cord-275041-fcdwitxy 150 10 with with IN cord-275041-fcdwitxy 150 11 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 150 12 treated treat VBN cord-275041-fcdwitxy 150 13 with with IN cord-275041-fcdwitxy 150 14 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 150 15 / / SYM cord-275041-fcdwitxy 150 16 azithromycin azithromycin NNP cord-275041-fcdwitxy 150 17 Optimizing optimize VBG cord-275041-fcdwitxy 150 18 hydroxychloroquine hydroxychloroquine NN cord-275041-fcdwitxy 150 19 dosing dose VBG cord-275041-fcdwitxy 150 20 for for IN cord-275041-fcdwitxy 150 21 patients patient NNS cord-275041-fcdwitxy 150 22 with with IN cord-275041-fcdwitxy 150 23 COVID-19 COVID-19 NNP cord-275041-fcdwitxy 150 24 : : : cord-275041-fcdwitxy 150 25 an an DT cord-275041-fcdwitxy 150 26 integrative integrative JJ cord-275041-fcdwitxy 150 27 modeling modeling NN cord-275041-fcdwitxy 150 28 approach approach NN cord-275041-fcdwitxy 150 29 for for IN cord-275041-fcdwitxy 150 30 effective effective JJ cord-275041-fcdwitxy 150 31 drug drug NN cord-275041-fcdwitxy 150 32 repurposing repurposing NN cord-275041-fcdwitxy 151 1 Acknowledgements acknowledgement NNS cord-275041-fcdwitxy 151 2 Thank thank VBP cord-275041-fcdwitxy 151 3 you -PRON- PRP cord-275041-fcdwitxy 151 4 to to IN cord-275041-fcdwitxy 151 5 all all DT cord-275041-fcdwitxy 151 6 clinicians clinician NNS cord-275041-fcdwitxy 151 7 and and CC cord-275041-fcdwitxy 151 8 administrators administrator NNS cord-275041-fcdwitxy 151 9 of of IN cord-275041-fcdwitxy 151 10 Hospitales Hospitales NNP cord-275041-fcdwitxy 151 11 HM HM NNP cord-275041-fcdwitxy 151 12 ( ( -LRB- cord-275041-fcdwitxy 151 13 Spain Spain NNP cord-275041-fcdwitxy 151 14 ) ) -RRB- cord-275041-fcdwitxy 151 15 on on IN cord-275041-fcdwitxy 151 16 which which WDT cord-275041-fcdwitxy 151 17 data datum NNS cord-275041-fcdwitxy 151 18 this this DT cord-275041-fcdwitxy 151 19 study study NN cord-275041-fcdwitxy 151 20 is be VBZ cord-275041-fcdwitxy 151 21 based base VBN cord-275041-fcdwitxy 151 22 . . . cord-275041-fcdwitxy 152 1 Funding fund VBG cord-275041-fcdwitxy 152 2 Salma Salma NNP cord-275041-fcdwitxy 152 3 Ayis Ayis NNP cord-275041-fcdwitxy 152 4 was be VBD cord-275041-fcdwitxy 152 5 funded fund VBN cord-275041-fcdwitxy 152 6 by by IN cord-275041-fcdwitxy 152 7 the the DT cord-275041-fcdwitxy 152 8 National National NNP cord-275041-fcdwitxy 152 9 Institute Institute NNP cord-275041-fcdwitxy 152 10 for for IN cord-275041-fcdwitxy 152 11 Health Health NNP cord-275041-fcdwitxy 152 12 Research Research NNP cord-275041-fcdwitxy 152 13 ( ( -LRB- cord-275041-fcdwitxy 152 14 NIHR NIHR NNP cord-275041-fcdwitxy 152 15 ) ) -RRB- cord-275041-fcdwitxy 152 16 Biomedical Biomedical NNP cord-275041-fcdwitxy 152 17 Research Research NNP cord-275041-fcdwitxy 152 18 Centre Centre NNP cord-275041-fcdwitxy 152 19 based base VBN cord-275041-fcdwitxy 152 20 at at IN cord-275041-fcdwitxy 152 21 Guy Guy NNP cord-275041-fcdwitxy 152 22 's 's POS cord-275041-fcdwitxy 152 23 and and CC cord-275041-fcdwitxy 152 24 St St NNP cord-275041-fcdwitxy 152 25 Thomas Thomas NNP cord-275041-fcdwitxy 152 26 ' ' POS cord-275041-fcdwitxy 152 27 NHS NHS NNP cord-275041-fcdwitxy 152 28 Foundation Foundation NNP cord-275041-fcdwitxy 152 29 Trust Trust NNP cord-275041-fcdwitxy 152 30 and and CC cord-275041-fcdwitxy 152 31 King King NNP cord-275041-fcdwitxy 152 32 's 's POS cord-275041-fcdwitxy 152 33 College College NNP cord-275041-fcdwitxy 152 34 London London NNP cord-275041-fcdwitxy 152 35 . . . cord-275041-fcdwitxy 153 1 The the DT cord-275041-fcdwitxy 153 2 views view NNS cord-275041-fcdwitxy 153 3 expressed express VBN cord-275041-fcdwitxy 153 4 are be VBP cord-275041-fcdwitxy 153 5 those those DT cord-275041-fcdwitxy 153 6 of of IN cord-275041-fcdwitxy 153 7 the the DT cord-275041-fcdwitxy 153 8 authors author NNS cord-275041-fcdwitxy 153 9 and and CC cord-275041-fcdwitxy 153 10 not not RB cord-275041-fcdwitxy 153 11 necessarily necessarily RB cord-275041-fcdwitxy 153 12 those those DT cord-275041-fcdwitxy 153 13 of of IN cord-275041-fcdwitxy 153 14 the the DT cord-275041-fcdwitxy 153 15 NHS NHS NNP cord-275041-fcdwitxy 153 16 , , , cord-275041-fcdwitxy 153 17 the the DT cord-275041-fcdwitxy 153 18 NIHR NIHR NNP cord-275041-fcdwitxy 153 19 , , , cord-275041-fcdwitxy 153 20 or or CC cord-275041-fcdwitxy 153 21 the the DT cord-275041-fcdwitxy 153 22 Department Department NNP cord-275041-fcdwitxy 153 23 of of IN cord-275041-fcdwitxy 153 24 Health Health NNP cord-275041-fcdwitxy 153 25 . . .