id sid tid token lemma pos cord-028530-hpgrbhkl 1 1 key key JJ cord-028530-hpgrbhkl 1 2 : : : cord-028530-hpgrbhkl 1 3 cord-028530-hpgrbhkl cord-028530-hpgrbhkl ADD cord-028530-hpgrbhkl 2 1 authors author NNS cord-028530-hpgrbhkl 2 2 : : : cord-028530-hpgrbhkl 2 3 Cairoli Cairoli NNP cord-028530-hpgrbhkl 2 4 , , , cord-028530-hpgrbhkl 2 5 Ernesto Ernesto NNP cord-028530-hpgrbhkl 2 6 ; ; : cord-028530-hpgrbhkl 2 7 Espinosa Espinosa NNP cord-028530-hpgrbhkl 2 8 , , , cord-028530-hpgrbhkl 3 1 Gerard Gerard NNP cord-028530-hpgrbhkl 3 2 title title NN cord-028530-hpgrbhkl 3 3 : : : cord-028530-hpgrbhkl 3 4 Hydroxychloroquine Hydroxychloroquine NNP cord-028530-hpgrbhkl 3 5 in in IN cord-028530-hpgrbhkl 3 6 the the DT cord-028530-hpgrbhkl 3 7 treatment treatment NN cord-028530-hpgrbhkl 3 8 of of IN cord-028530-hpgrbhkl 3 9 COVID-19 covid-19 NN cord-028530-hpgrbhkl 3 10 : : : cord-028530-hpgrbhkl 4 1 how how WRB cord-028530-hpgrbhkl 4 2 to to TO cord-028530-hpgrbhkl 4 3 use use VB cord-028530-hpgrbhkl 4 4 it -PRON- PRP cord-028530-hpgrbhkl 4 5 waiting wait VBG cord-028530-hpgrbhkl 4 6 for for IN cord-028530-hpgrbhkl 4 7 conclusive conclusive JJ cord-028530-hpgrbhkl 4 8 scientific scientific JJ cord-028530-hpgrbhkl 4 9 evidence evidence NN cord-028530-hpgrbhkl 4 10 ( ( -LRB- cord-028530-hpgrbhkl 4 11 ) ) -RRB- cord-028530-hpgrbhkl 4 12 date date NN cord-028530-hpgrbhkl 4 13 : : : cord-028530-hpgrbhkl 4 14 2020 2020 CD cord-028530-hpgrbhkl 4 15 - - HYPH cord-028530-hpgrbhkl 4 16 07 07 CD cord-028530-hpgrbhkl 4 17 - - HYPH cord-028530-hpgrbhkl 4 18 04 04 CD cord-028530-hpgrbhkl 4 19 journal journal NN cord-028530-hpgrbhkl 4 20 : : : cord-028530-hpgrbhkl 5 1 Med Med NNP cord-028530-hpgrbhkl 5 2 Clin Clin NNP cord-028530-hpgrbhkl 5 3 ( ( -LRB- cord-028530-hpgrbhkl 5 4 Engl Engl NNP cord-028530-hpgrbhkl 5 5 Ed Ed NNP cord-028530-hpgrbhkl 5 6 ) ) -RRB- cord-028530-hpgrbhkl 5 7 DOI DOI NNP cord-028530-hpgrbhkl 5 8 : : : cord-028530-hpgrbhkl 5 9 10.1016/ 10.1016/ CD cord-028530-hpgrbhkl 6 1 j.medcle.2020.05.003 j.medcle.2020.05.003 NNP cord-028530-hpgrbhkl 6 2 sha sha NNP cord-028530-hpgrbhkl 6 3 : : : cord-028530-hpgrbhkl 6 4 80b833e0eb1e15eaeb77ce67470d0ddb502e7cdf 80b833e0eb1e15eaeb77ce67470d0ddb502e7cdf CD cord-028530-hpgrbhkl 6 5 doc_id doc_id CD cord-028530-hpgrbhkl 6 6 : : : cord-028530-hpgrbhkl 6 7 28530 28530 CD cord-028530-hpgrbhkl 6 8 cord_uid cord_uid NNS cord-028530-hpgrbhkl 6 9 : : : cord-028530-hpgrbhkl 6 10 hpgrbhkl hpgrbhkl NNP cord-028530-hpgrbhkl 7 1 nan nan NNP cord-028530-hpgrbhkl 7 2 Letter Letter NNP cord-028530-hpgrbhkl 7 3 to to IN cord-028530-hpgrbhkl 7 4 the the DT cord-028530-hpgrbhkl 7 5 Editor Editor NNP cord-028530-hpgrbhkl 7 6 Hidroxicloroquina Hidroxicloroquina NNP cord-028530-hpgrbhkl 7 7 en en IN cord-028530-hpgrbhkl 7 8 el el NNP cord-028530-hpgrbhkl 7 9 tratamiento tratamiento NNP cord-028530-hpgrbhkl 7 10 del del NNP cord-028530-hpgrbhkl 8 1 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 8 2 : : : cord-028530-hpgrbhkl 8 3 como como NNP cord-028530-hpgrbhkl 8 4 utilizarla utilizarla NNP cord-028530-hpgrbhkl 8 5 a a NNP cord-028530-hpgrbhkl 8 6 la la FW cord-028530-hpgrbhkl 8 7 espera espera FW cord-028530-hpgrbhkl 8 8 de de FW cord-028530-hpgrbhkl 8 9 evidencia evidencia NNP cord-028530-hpgrbhkl 8 10 científica científica NNP cord-028530-hpgrbhkl 8 11 concluyente concluyente NNP cord-028530-hpgrbhkl 8 12 . . . cord-028530-hpgrbhkl 9 1 Hydroxychloroquine Hydroxychloroquine NNP cord-028530-hpgrbhkl 9 2 in in IN cord-028530-hpgrbhkl 9 3 the the DT cord-028530-hpgrbhkl 9 4 treatment treatment NN cord-028530-hpgrbhkl 9 5 of of IN cord-028530-hpgrbhkl 9 6 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 9 7 : : : cord-028530-hpgrbhkl 9 8 how how WRB cord-028530-hpgrbhkl 9 9 to to TO cord-028530-hpgrbhkl 9 10 use use VB cord-028530-hpgrbhkl 9 11 it -PRON- PRP cord-028530-hpgrbhkl 9 12 waiting wait VBG cord-028530-hpgrbhkl 9 13 for for IN cord-028530-hpgrbhkl 9 14 conclusive conclusive JJ cord-028530-hpgrbhkl 9 15 scientific scientific JJ cord-028530-hpgrbhkl 9 16 evidence evidence NN cord-028530-hpgrbhkl 10 1 Autores autore NNS cord-028530-hpgrbhkl 10 2 : : : cord-028530-hpgrbhkl 10 3 Ernesto Ernesto NNP cord-028530-hpgrbhkl 10 4 Cairoli Cairoli NNP cord-028530-hpgrbhkl 10 5 MD MD NNP cord-028530-hpgrbhkl 10 6 , , , cord-028530-hpgrbhkl 10 7 PhD PhD NNP cord-028530-hpgrbhkl 10 8 a a NNP cord-028530-hpgrbhkl 10 9 , , , cord-028530-hpgrbhkl 10 10 b b NN cord-028530-hpgrbhkl 10 11 , , , cord-028530-hpgrbhkl 10 12 Gerard Gerard NNP cord-028530-hpgrbhkl 10 13 Espinosa Espinosa NNP cord-028530-hpgrbhkl 10 14 MD MD NNP cord-028530-hpgrbhkl 10 15 , , , cord-028530-hpgrbhkl 10 16 PhD PhD NNP cord-028530-hpgrbhkl 10 17 c c NNP cord-028530-hpgrbhkl 10 18 . . . cord-028530-hpgrbhkl 10 19 _SP cord-028530-hpgrbhkl 11 1 To to IN cord-028530-hpgrbhkl 11 2 date date NN cord-028530-hpgrbhkl 11 3 , , , cord-028530-hpgrbhkl 11 4 there there EX cord-028530-hpgrbhkl 11 5 is be VBZ cord-028530-hpgrbhkl 11 6 no no DT cord-028530-hpgrbhkl 11 7 effective effective JJ cord-028530-hpgrbhkl 11 8 treatment treatment NN cord-028530-hpgrbhkl 11 9 against against IN cord-028530-hpgrbhkl 11 10 the the DT cord-028530-hpgrbhkl 11 11 novel novel JJ cord-028530-hpgrbhkl 11 12 severe severe JJ cord-028530-hpgrbhkl 11 13 acute acute JJ cord-028530-hpgrbhkl 11 14 respiratory respiratory JJ cord-028530-hpgrbhkl 11 15 syndrome syndrome NN cord-028530-hpgrbhkl 11 16 coronavirus coronavirus NN cord-028530-hpgrbhkl 11 17 2 2 CD cord-028530-hpgrbhkl 11 18 ( ( -LRB- cord-028530-hpgrbhkl 11 19 SARS SARS NNP cord-028530-hpgrbhkl 11 20 - - HYPH cord-028530-hpgrbhkl 11 21 CoV-2 CoV-2 NNP cord-028530-hpgrbhkl 11 22 ) ) -RRB- cord-028530-hpgrbhkl 11 23 , , , cord-028530-hpgrbhkl 11 24 responsible responsible JJ cord-028530-hpgrbhkl 11 25 for for IN cord-028530-hpgrbhkl 11 26 the the DT cord-028530-hpgrbhkl 11 27 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 11 28 disease disease NN cord-028530-hpgrbhkl 11 29 . . . cord-028530-hpgrbhkl 12 1 Numerous numerous JJ cord-028530-hpgrbhkl 12 2 clinical clinical JJ cord-028530-hpgrbhkl 12 3 studies study NNS cord-028530-hpgrbhkl 12 4 are be VBP cord-028530-hpgrbhkl 12 5 evaluating evaluate VBG cord-028530-hpgrbhkl 12 6 the the DT cord-028530-hpgrbhkl 12 7 utility utility NN cord-028530-hpgrbhkl 12 8 of of IN cord-028530-hpgrbhkl 12 9 antiviral antiviral JJ cord-028530-hpgrbhkl 12 10 and and CC cord-028530-hpgrbhkl 12 11 immunomodulatory immunomodulatory JJ cord-028530-hpgrbhkl 12 12 drugs drug NNS cord-028530-hpgrbhkl 12 13 , , , cord-028530-hpgrbhkl 12 14 where where WRB cord-028530-hpgrbhkl 12 15 antimalarials antimalarial NNS cord-028530-hpgrbhkl 12 16 such such JJ cord-028530-hpgrbhkl 12 17 as as IN cord-028530-hpgrbhkl 12 18 chloroquine chloroquine NNP cord-028530-hpgrbhkl 12 19 and and CC cord-028530-hpgrbhkl 12 20 hydroxychloroquine hydroxychloroquine NNP cord-028530-hpgrbhkl 12 21 ( ( -LRB- cord-028530-hpgrbhkl 12 22 HCQ HCQ NNP cord-028530-hpgrbhkl 12 23 ) ) -RRB- cord-028530-hpgrbhkl 12 24 are be VBP cord-028530-hpgrbhkl 12 25 one one CD cord-028530-hpgrbhkl 12 26 of of IN cord-028530-hpgrbhkl 12 27 the the DT cord-028530-hpgrbhkl 12 28 alternatives alternative NNS cord-028530-hpgrbhkl 12 29 studied study VBD cord-028530-hpgrbhkl 12 30 1 1 CD cord-028530-hpgrbhkl 12 31 . . . cord-028530-hpgrbhkl 13 1 So so RB cord-028530-hpgrbhkl 13 2 far far RB cord-028530-hpgrbhkl 13 3 , , , cord-028530-hpgrbhkl 13 4 clinical clinical JJ cord-028530-hpgrbhkl 13 5 experience experience NN cord-028530-hpgrbhkl 13 6 in in IN cord-028530-hpgrbhkl 13 7 the the DT cord-028530-hpgrbhkl 13 8 use use NN cord-028530-hpgrbhkl 13 9 of of IN cord-028530-hpgrbhkl 13 10 HCQ HCQ NNP cord-028530-hpgrbhkl 13 11 arises arise VBZ cord-028530-hpgrbhkl 13 12 mainly mainly RB cord-028530-hpgrbhkl 13 13 from from IN cord-028530-hpgrbhkl 13 14 treatment treatment NN cord-028530-hpgrbhkl 13 15 in in IN cord-028530-hpgrbhkl 13 16 patients patient NNS cord-028530-hpgrbhkl 13 17 with with IN cord-028530-hpgrbhkl 13 18 systemic systemic JJ cord-028530-hpgrbhkl 13 19 lupus lupus NN cord-028530-hpgrbhkl 13 20 erythematosus erythematosus NN cord-028530-hpgrbhkl 13 21 ( ( -LRB- cord-028530-hpgrbhkl 13 22 SLE SLE NNP cord-028530-hpgrbhkl 13 23 ) ) -RRB- cord-028530-hpgrbhkl 13 24 , , , cord-028530-hpgrbhkl 13 25 whose whose WP$ cord-028530-hpgrbhkl 13 26 long long JJ cord-028530-hpgrbhkl 13 27 - - HYPH cord-028530-hpgrbhkl 13 28 term term NN cord-028530-hpgrbhkl 13 29 effects effect NNS cord-028530-hpgrbhkl 13 30 show show VBP cord-028530-hpgrbhkl 13 31 multiple multiple JJ cord-028530-hpgrbhkl 13 32 benefits benefit NNS cord-028530-hpgrbhkl 13 33 . . . cord-028530-hpgrbhkl 14 1 However however RB cord-028530-hpgrbhkl 14 2 , , , cord-028530-hpgrbhkl 14 3 high high JJ cord-028530-hpgrbhkl 14 4 cumulative cumulative JJ cord-028530-hpgrbhkl 14 5 doses dose NNS cord-028530-hpgrbhkl 14 6 have have VBP cord-028530-hpgrbhkl 14 7 been be VBN cord-028530-hpgrbhkl 14 8 associated associate VBN cord-028530-hpgrbhkl 14 9 with with IN cord-028530-hpgrbhkl 14 10 serious serious JJ cord-028530-hpgrbhkl 14 11 adverse adverse JJ cord-028530-hpgrbhkl 14 12 effects effect NNS cord-028530-hpgrbhkl 14 13 , , , cord-028530-hpgrbhkl 14 14 especially especially RB cord-028530-hpgrbhkl 14 15 in in IN cord-028530-hpgrbhkl 14 16 the the DT cord-028530-hpgrbhkl 14 17 retina retina NN cord-028530-hpgrbhkl 14 18 and and CC cord-028530-hpgrbhkl 14 19 myocardium myocardium NN cord-028530-hpgrbhkl 14 20 2 2 CD cord-028530-hpgrbhkl 14 21 . . . cord-028530-hpgrbhkl 15 1 Many many JJ cord-028530-hpgrbhkl 15 2 healthcare healthcare NN cord-028530-hpgrbhkl 15 3 protocols protocol NNS cord-028530-hpgrbhkl 15 4 propose propose VBP cord-028530-hpgrbhkl 15 5 the the DT cord-028530-hpgrbhkl 15 6 use use NN cord-028530-hpgrbhkl 15 7 of of IN cord-028530-hpgrbhkl 15 8 HCQ HCQ NNP cord-028530-hpgrbhkl 15 9 in in IN cord-028530-hpgrbhkl 15 10 the the DT cord-028530-hpgrbhkl 15 11 treatment treatment NN cord-028530-hpgrbhkl 15 12 of of IN cord-028530-hpgrbhkl 15 13 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 15 14 1 1 CD cord-028530-hpgrbhkl 15 15 . . . cord-028530-hpgrbhkl 16 1 However however RB cord-028530-hpgrbhkl 16 2 , , , cord-028530-hpgrbhkl 16 3 it -PRON- PRP cord-028530-hpgrbhkl 16 4 is be VBZ cord-028530-hpgrbhkl 16 5 important important JJ cord-028530-hpgrbhkl 16 6 to to TO cord-028530-hpgrbhkl 16 7 consider consider VB cord-028530-hpgrbhkl 16 8 adverse adverse JJ cord-028530-hpgrbhkl 16 9 myocardial myocardial JJ cord-028530-hpgrbhkl 16 10 effects effect NNS cord-028530-hpgrbhkl 16 11 , , , cord-028530-hpgrbhkl 16 12 such such JJ cord-028530-hpgrbhkl 16 13 as as IN cord-028530-hpgrbhkl 16 14 the the DT cord-028530-hpgrbhkl 16 15 development development NN cord-028530-hpgrbhkl 16 16 of of IN cord-028530-hpgrbhkl 16 17 severe severe JJ cord-028530-hpgrbhkl 16 18 arrhythmias arrhythmia NNS cord-028530-hpgrbhkl 16 19 3 3 CD cord-028530-hpgrbhkl 16 20 , , , cord-028530-hpgrbhkl 16 21 4 4 CD cord-028530-hpgrbhkl 16 22 . . . cord-028530-hpgrbhkl 17 1 In in IN cord-028530-hpgrbhkl 17 2 the the DT cord-028530-hpgrbhkl 17 3 COVID-19 covid-19 JJ cord-028530-hpgrbhkl 17 4 patient patient NN cord-028530-hpgrbhkl 17 5 , , , cord-028530-hpgrbhkl 17 6 possible possible JJ cord-028530-hpgrbhkl 17 7 cardiac cardiac JJ cord-028530-hpgrbhkl 17 8 involvement involvement NN cord-028530-hpgrbhkl 17 9 is be VBZ cord-028530-hpgrbhkl 17 10 mainly mainly RB cord-028530-hpgrbhkl 17 11 related relate VBN cord-028530-hpgrbhkl 17 12 to to IN cord-028530-hpgrbhkl 17 13 4 4 CD cord-028530-hpgrbhkl 17 14 factors factor NNS cord-028530-hpgrbhkl 17 15 : : : cord-028530-hpgrbhkl 17 16 1 1 LS cord-028530-hpgrbhkl 17 17 ) ) -RRB- cord-028530-hpgrbhkl 17 18 underlying underlie VBG cord-028530-hpgrbhkl 17 19 heart heart NN cord-028530-hpgrbhkl 17 20 disease disease NN cord-028530-hpgrbhkl 17 21 ( ( -LRB- cord-028530-hpgrbhkl 17 22 often often RB cord-028530-hpgrbhkl 17 23 silent silent JJ cord-028530-hpgrbhkl 17 24 in in IN cord-028530-hpgrbhkl 17 25 older old JJR cord-028530-hpgrbhkl 17 26 patients patient NNS cord-028530-hpgrbhkl 17 27 ) ) -RRB- cord-028530-hpgrbhkl 17 28 ; ; : cord-028530-hpgrbhkl 17 29 2 2 LS cord-028530-hpgrbhkl 17 30 ) ) -RRB- cord-028530-hpgrbhkl 17 31 myocardial myocardial JJ cord-028530-hpgrbhkl 17 32 involvement involvement NN cord-028530-hpgrbhkl 17 33 caused cause VBN cord-028530-hpgrbhkl 17 34 by by IN cord-028530-hpgrbhkl 17 35 the the DT cord-028530-hpgrbhkl 17 36 infection infection NN cord-028530-hpgrbhkl 17 37 and and CC cord-028530-hpgrbhkl 17 38 the the DT cord-028530-hpgrbhkl 17 39 inflammatory inflammatory JJ cord-028530-hpgrbhkl 17 40 response response NN cord-028530-hpgrbhkl 17 41 itself -PRON- PRP cord-028530-hpgrbhkl 17 42 , , , cord-028530-hpgrbhkl 17 43 which which WDT cord-028530-hpgrbhkl 17 44 leads lead VBZ cord-028530-hpgrbhkl 17 45 to to TO cord-028530-hpgrbhkl 17 46 myocarditis myocarditis VB cord-028530-hpgrbhkl 17 47 with with IN cord-028530-hpgrbhkl 17 48 elevated elevated JJ cord-028530-hpgrbhkl 17 49 troponins troponin NNS cord-028530-hpgrbhkl 17 50 ; ; : cord-028530-hpgrbhkl 17 51 3 3 LS cord-028530-hpgrbhkl 17 52 ) ) -RRB- cord-028530-hpgrbhkl 17 53 acute acute JJ cord-028530-hpgrbhkl 17 54 toxicity toxicity NN cord-028530-hpgrbhkl 17 55 probably probably RB cord-028530-hpgrbhkl 17 56 associated associate VBD cord-028530-hpgrbhkl 17 57 with with IN cord-028530-hpgrbhkl 17 58 the the DT cord-028530-hpgrbhkl 17 59 use use NN cord-028530-hpgrbhkl 17 60 of of IN cord-028530-hpgrbhkl 17 61 antimalarials antimalarial NNS cord-028530-hpgrbhkl 17 62 in in IN cord-028530-hpgrbhkl 17 63 high high JJ cord-028530-hpgrbhkl 17 64 doses dose NNS cord-028530-hpgrbhkl 17 65 , , , cord-028530-hpgrbhkl 17 66 more more RBR cord-028530-hpgrbhkl 17 67 evident evident JJ cord-028530-hpgrbhkl 17 68 in in IN cord-028530-hpgrbhkl 17 69 chloroquine chloroquine NN cord-028530-hpgrbhkl 17 70 treatments treatment NNS cord-028530-hpgrbhkl 17 71 and and CC cord-028530-hpgrbhkl 17 72 4 4 CD cord-028530-hpgrbhkl 17 73 ) ) -RRB- cord-028530-hpgrbhkl 17 74 concomitant concomitant JJ cord-028530-hpgrbhkl 17 75 use use NN cord-028530-hpgrbhkl 17 76 of of IN cord-028530-hpgrbhkl 17 77 other other JJ cord-028530-hpgrbhkl 17 78 treatments treatment NNS cord-028530-hpgrbhkl 17 79 that that WDT cord-028530-hpgrbhkl 17 80 , , , cord-028530-hpgrbhkl 17 81 together together RB cord-028530-hpgrbhkl 17 82 with with IN cord-028530-hpgrbhkl 17 83 HCQ HCQ NNP cord-028530-hpgrbhkl 17 84 , , , cord-028530-hpgrbhkl 17 85 prolong prolong VB cord-028530-hpgrbhkl 17 86 the the DT cord-028530-hpgrbhkl 17 87 corrected correct VBN cord-028530-hpgrbhkl 17 88 QT qt NN cord-028530-hpgrbhkl 17 89 interval interval NN cord-028530-hpgrbhkl 17 90 ( ( -LRB- cord-028530-hpgrbhkl 17 91 QTc QTc NNP cord-028530-hpgrbhkl 17 92 ) ) -RRB- cord-028530-hpgrbhkl 17 93 , , , cord-028530-hpgrbhkl 17 94 with with IN cord-028530-hpgrbhkl 17 95 the the DT cord-028530-hpgrbhkl 17 96 risk risk NN cord-028530-hpgrbhkl 17 97 of of IN cord-028530-hpgrbhkl 17 98 serious serious JJ cord-028530-hpgrbhkl 17 99 ventricular ventricular JJ cord-028530-hpgrbhkl 17 100 arrhythmias arrhythmias RB cord-028530-hpgrbhkl 17 101 3 3 CD cord-028530-hpgrbhkl 17 102 - - SYM cord-028530-hpgrbhkl 17 103 5 5 CD cord-028530-hpgrbhkl 17 104 . . . cord-028530-hpgrbhkl 18 1 In in IN cord-028530-hpgrbhkl 18 2 the the DT cord-028530-hpgrbhkl 18 3 absence absence NN cord-028530-hpgrbhkl 18 4 ( ( -LRB- cord-028530-hpgrbhkl 18 5 pending pende VBG cord-028530-hpgrbhkl 18 6 ) ) -RRB- cord-028530-hpgrbhkl 18 7 of of IN cord-028530-hpgrbhkl 18 8 conclusive conclusive JJ cord-028530-hpgrbhkl 18 9 scientific scientific JJ cord-028530-hpgrbhkl 18 10 evidence evidence NN cord-028530-hpgrbhkl 18 11 , , , cord-028530-hpgrbhkl 18 12 what what WDT cord-028530-hpgrbhkl 18 13 considerations consideration NNS cord-028530-hpgrbhkl 18 14 should should MD cord-028530-hpgrbhkl 18 15 be be VB cord-028530-hpgrbhkl 18 16 taken take VBN cord-028530-hpgrbhkl 18 17 into into IN cord-028530-hpgrbhkl 18 18 account account NN cord-028530-hpgrbhkl 18 19 when when WRB cord-028530-hpgrbhkl 18 20 using use VBG cord-028530-hpgrbhkl 18 21 HCQ HCQ NNP cord-028530-hpgrbhkl 18 22 in in IN cord-028530-hpgrbhkl 18 23 the the DT cord-028530-hpgrbhkl 18 24 treatment treatment NN cord-028530-hpgrbhkl 18 25 of of IN cord-028530-hpgrbhkl 18 26 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 18 27 ? ? . cord-028530-hpgrbhkl 19 1 It -PRON- PRP cord-028530-hpgrbhkl 19 2 is be VBZ cord-028530-hpgrbhkl 19 3 necessary necessary JJ cord-028530-hpgrbhkl 19 4 to to TO cord-028530-hpgrbhkl 19 5 change change VB cord-028530-hpgrbhkl 19 6 the the DT cord-028530-hpgrbhkl 19 7 way way NN cord-028530-hpgrbhkl 19 8 in in IN cord-028530-hpgrbhkl 19 9 which which WDT cord-028530-hpgrbhkl 19 10 HCQ HCQ NNP cord-028530-hpgrbhkl 19 11 is be VBZ cord-028530-hpgrbhkl 19 12 usually usually RB cord-028530-hpgrbhkl 19 13 used use VBN cord-028530-hpgrbhkl 19 14 in in IN cord-028530-hpgrbhkl 19 15 patients patient NNS cord-028530-hpgrbhkl 19 16 with with IN cord-028530-hpgrbhkl 19 17 SLE SLE NNP cord-028530-hpgrbhkl 19 18 , , , cord-028530-hpgrbhkl 19 19 adapting adapt VBG cord-028530-hpgrbhkl 19 20 its -PRON- PRP$ cord-028530-hpgrbhkl 19 21 prescription prescription NN cord-028530-hpgrbhkl 19 22 and and CC cord-028530-hpgrbhkl 19 23 control control NN cord-028530-hpgrbhkl 19 24 of of IN cord-028530-hpgrbhkl 19 25 potential potential JJ cord-028530-hpgrbhkl 19 26 adverse adverse JJ cord-028530-hpgrbhkl 19 27 effects effect NNS cord-028530-hpgrbhkl 19 28 to to IN cord-028530-hpgrbhkl 19 29 this this DT cord-028530-hpgrbhkl 19 30 new new JJ cord-028530-hpgrbhkl 19 31 therapeutic therapeutic JJ cord-028530-hpgrbhkl 19 32 scenario scenario NN cord-028530-hpgrbhkl 19 33 . . . cord-028530-hpgrbhkl 20 1 The the DT cord-028530-hpgrbhkl 20 2 following following JJ cord-028530-hpgrbhkl 20 3 considerations consideration NNS cord-028530-hpgrbhkl 20 4 aim aim VBP cord-028530-hpgrbhkl 20 5 to to TO cord-028530-hpgrbhkl 20 6 optimize optimize VB cord-028530-hpgrbhkl 20 7 the the DT cord-028530-hpgrbhkl 20 8 HCQ HCQ NNP cord-028530-hpgrbhkl 20 9 treatment treatment NN cord-028530-hpgrbhkl 20 10 of of IN cord-028530-hpgrbhkl 20 11 COVID-19 covid-19 NN cord-028530-hpgrbhkl 20 12 : : : cord-028530-hpgrbhkl 20 13 -When -When NFP cord-028530-hpgrbhkl 20 14 the the DT cord-028530-hpgrbhkl 20 15 doctor doctor NN cord-028530-hpgrbhkl 20 16 considers consider VBZ cord-028530-hpgrbhkl 20 17 that that IN cord-028530-hpgrbhkl 20 18 HCQ HCQ NNP cord-028530-hpgrbhkl 20 19 can can MD cord-028530-hpgrbhkl 20 20 be be VB cord-028530-hpgrbhkl 20 21 useful useful JJ cord-028530-hpgrbhkl 20 22 , , , cord-028530-hpgrbhkl 20 23 it -PRON- PRP cord-028530-hpgrbhkl 20 24 should should MD cord-028530-hpgrbhkl 20 25 be be VB cord-028530-hpgrbhkl 20 26 initiated initiate VBN cord-028530-hpgrbhkl 20 27 as as RB cord-028530-hpgrbhkl 20 28 early early RB cord-028530-hpgrbhkl 20 29 as as IN cord-028530-hpgrbhkl 20 30 possible possible JJ cord-028530-hpgrbhkl 20 31 after after IN cord-028530-hpgrbhkl 20 32 diagnosing diagnose VBG cord-028530-hpgrbhkl 20 33 the the DT cord-028530-hpgrbhkl 20 34 infection infection NN cord-028530-hpgrbhkl 20 35 , , , cord-028530-hpgrbhkl 20 36 due due IN cord-028530-hpgrbhkl 20 37 to to IN cord-028530-hpgrbhkl 20 38 the the DT cord-028530-hpgrbhkl 20 39 decrease decrease NN cord-028530-hpgrbhkl 20 40 in in IN cord-028530-hpgrbhkl 20 41 viral viral JJ cord-028530-hpgrbhkl 20 42 replication replication NN cord-028530-hpgrbhkl 20 43 and and CC cord-028530-hpgrbhkl 20 44 dissemination dissemination NN cord-028530-hpgrbhkl 20 45 demonstrated demonstrate VBN cord-028530-hpgrbhkl 20 46 in in IN cord-028530-hpgrbhkl 20 47 vitro vitro FW cord-028530-hpgrbhkl 20 48 and and CC cord-028530-hpgrbhkl 20 49 in in IN cord-028530-hpgrbhkl 20 50 vivo vivo NNP cord-028530-hpgrbhkl 20 51 1 1 CD cord-028530-hpgrbhkl 20 52 . . . cord-028530-hpgrbhkl 21 1 -Using -use VBG cord-028530-hpgrbhkl 21 2 HCQ HCQ NNP cord-028530-hpgrbhkl 21 3 in in IN cord-028530-hpgrbhkl 21 4 an an DT cord-028530-hpgrbhkl 21 5 acute acute JJ cord-028530-hpgrbhkl 21 6 treatment treatment NN cord-028530-hpgrbhkl 21 7 ( ( -LRB- cord-028530-hpgrbhkl 21 8 5 5 CD cord-028530-hpgrbhkl 21 9 days day NNS cord-028530-hpgrbhkl 21 10 ) ) -RRB- cord-028530-hpgrbhkl 21 11 , , , cord-028530-hpgrbhkl 21 12 with with IN cord-028530-hpgrbhkl 21 13 loading loading NN cord-028530-hpgrbhkl 21 14 dose dose NN cord-028530-hpgrbhkl 21 15 ( ( -LRB- cord-028530-hpgrbhkl 21 16 400 400 CD cord-028530-hpgrbhkl 21 17 ░ ░ NNP cord-028530-hpgrbhkl 21 18 mg mg NNP cord-028530-hpgrbhkl 21 19 / / SYM cord-028530-hpgrbhkl 21 20 every every DT cord-028530-hpgrbhkl 21 21 12 12 CD cord-028530-hpgrbhkl 21 22 ░ ░ NNP cord-028530-hpgrbhkl 21 23 h h NN cord-028530-hpgrbhkl 21 24 ) ) -RRB- cord-028530-hpgrbhkl 21 25 the the DT cord-028530-hpgrbhkl 21 26 first first JJ cord-028530-hpgrbhkl 21 27 day day NN cord-028530-hpgrbhkl 21 28 and and CC cord-028530-hpgrbhkl 21 29 4 4 CD cord-028530-hpgrbhkl 21 30 days day NNS cord-028530-hpgrbhkl 21 31 of of IN cord-028530-hpgrbhkl 21 32 maintenance maintenance NN cord-028530-hpgrbhkl 21 33 ( ( -LRB- cord-028530-hpgrbhkl 21 34 200 200 CD cord-028530-hpgrbhkl 21 35 ░ ░ NNP cord-028530-hpgrbhkl 21 36 mg mg NNP cord-028530-hpgrbhkl 21 37 / / : cord-028530-hpgrbhkl 21 38 every every DT cord-028530-hpgrbhkl 21 39 12 12 CD cord-028530-hpgrbhkl 21 40 ░ ░ NNP cord-028530-hpgrbhkl 21 41 h h NN cord-028530-hpgrbhkl 21 42 ) ) -RRB- cord-028530-hpgrbhkl 21 43 , , , cord-028530-hpgrbhkl 21 44 after after IN cord-028530-hpgrbhkl 21 45 requesting request VBG cord-028530-hpgrbhkl 21 46 an an DT cord-028530-hpgrbhkl 21 47 informed informed JJ cord-028530-hpgrbhkl 21 48 medical medical JJ cord-028530-hpgrbhkl 21 49 consent consent NN cord-028530-hpgrbhkl 21 50 ( ( -LRB- cord-028530-hpgrbhkl 21 51 with with IN cord-028530-hpgrbhkl 21 52 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 21 53 being be VBG cord-028530-hpgrbhkl 21 54 an an DT cord-028530-hpgrbhkl 21 55 indication indication NN cord-028530-hpgrbhkl 21 56 not not RB cord-028530-hpgrbhkl 21 57 contemplated contemplate VBN cord-028530-hpgrbhkl 21 58 in in IN cord-028530-hpgrbhkl 21 59 the the DT cord-028530-hpgrbhkl 21 60 SmPC smpc NN cord-028530-hpgrbhkl 21 61 ) ) -RRB- cord-028530-hpgrbhkl 21 62 . . . cord-028530-hpgrbhkl 22 1 -Minimize -minimize DT cord-028530-hpgrbhkl 22 2 the the DT cord-028530-hpgrbhkl 22 3 risk risk NN cord-028530-hpgrbhkl 22 4 of of IN cord-028530-hpgrbhkl 22 5 prolonged prolonged JJ cord-028530-hpgrbhkl 22 6 QTc qtc NN cord-028530-hpgrbhkl 22 7 . . . cord-028530-hpgrbhkl 23 1 For for IN cord-028530-hpgrbhkl 23 2 this this DT cord-028530-hpgrbhkl 23 3 , , , cord-028530-hpgrbhkl 23 4 a a DT cord-028530-hpgrbhkl 23 5 baseline baseline JJ cord-028530-hpgrbhkl 23 6 electrocardiogram electrocardiogram NN cord-028530-hpgrbhkl 23 7 ( ( -LRB- cord-028530-hpgrbhkl 23 8 ECG ECG NNP cord-028530-hpgrbhkl 23 9 ) ) -RRB- cord-028530-hpgrbhkl 23 10 must must MD cord-028530-hpgrbhkl 23 11 be be VB cord-028530-hpgrbhkl 23 12 performed perform VBN cord-028530-hpgrbhkl 23 13 prior prior RB cord-028530-hpgrbhkl 23 14 to to IN cord-028530-hpgrbhkl 23 15 the the DT cord-028530-hpgrbhkl 23 16 start start NN cord-028530-hpgrbhkl 23 17 of of IN cord-028530-hpgrbhkl 23 18 treatment treatment NN cord-028530-hpgrbhkl 23 19 . . . cord-028530-hpgrbhkl 24 1 If if IN cord-028530-hpgrbhkl 24 2 the the DT cord-028530-hpgrbhkl 24 3 QTc qtc NN cord-028530-hpgrbhkl 24 4 is be VBZ cord-028530-hpgrbhkl 24 5 greater great JJR cord-028530-hpgrbhkl 24 6 than than IN cord-028530-hpgrbhkl 24 7 or or CC cord-028530-hpgrbhkl 24 8 equal equal JJ cord-028530-hpgrbhkl 24 9 to to IN cord-028530-hpgrbhkl 24 10 500 500 CD cord-028530-hpgrbhkl 24 11 ░ ░ NNP cord-028530-hpgrbhkl 24 12 ms ms NNP cord-028530-hpgrbhkl 24 13 , , , cord-028530-hpgrbhkl 24 14 HCQ HCQ NNP cord-028530-hpgrbhkl 24 15 should should MD cord-028530-hpgrbhkl 24 16 not not RB cord-028530-hpgrbhkl 24 17 be be VB cord-028530-hpgrbhkl 24 18 started start VBN cord-028530-hpgrbhkl 24 19 . . . cord-028530-hpgrbhkl 25 1 If if IN cord-028530-hpgrbhkl 25 2 the the DT cord-028530-hpgrbhkl 25 3 QTc qtc NN cord-028530-hpgrbhkl 25 4 is be VBZ cord-028530-hpgrbhkl 25 5 less less JJR cord-028530-hpgrbhkl 25 6 than than IN cord-028530-hpgrbhkl 25 7 470 470 CD cord-028530-hpgrbhkl 25 8 ░ ░ NNP cord-028530-hpgrbhkl 25 9 ms ms NNP cord-028530-hpgrbhkl 25 10 in in IN cord-028530-hpgrbhkl 25 11 men man NNS cord-028530-hpgrbhkl 25 12 or or CC cord-028530-hpgrbhkl 25 13 less less JJR cord-028530-hpgrbhkl 25 14 than than IN cord-028530-hpgrbhkl 25 15 480 480 CD cord-028530-hpgrbhkl 25 16 ░ ░ NNP cord-028530-hpgrbhkl 25 17 ms ms NNP cord-028530-hpgrbhkl 25 18 in in IN cord-028530-hpgrbhkl 25 19 women woman NNS cord-028530-hpgrbhkl 25 20 , , , cord-028530-hpgrbhkl 25 21 treatment treatment NN cord-028530-hpgrbhkl 25 22 can can MD cord-028530-hpgrbhkl 25 23 be be VB cord-028530-hpgrbhkl 25 24 initiated initiate VBN cord-028530-hpgrbhkl 25 25 , , , cord-028530-hpgrbhkl 25 26 repeating repeat VBG cord-028530-hpgrbhkl 25 27 the the DT cord-028530-hpgrbhkl 25 28 ECG ECG NNP cord-028530-hpgrbhkl 25 29 in in IN cord-028530-hpgrbhkl 25 30 48 48 CD cord-028530-hpgrbhkl 25 31 ░ ░ NNP cord-028530-hpgrbhkl 25 32 h h NNP cord-028530-hpgrbhkl 25 33 . . . cord-028530-hpgrbhkl 26 1 If if IN cord-028530-hpgrbhkl 26 2 the the DT cord-028530-hpgrbhkl 26 3 QTc qtc NN cord-028530-hpgrbhkl 26 4 is be VBZ cord-028530-hpgrbhkl 26 5 greater great JJR cord-028530-hpgrbhkl 26 6 than than IN cord-028530-hpgrbhkl 26 7 or or CC cord-028530-hpgrbhkl 26 8 equal equal JJ cord-028530-hpgrbhkl 26 9 to to IN cord-028530-hpgrbhkl 26 10 500 500 CD cord-028530-hpgrbhkl 26 11 ░ ░ NNP cord-028530-hpgrbhkl 26 12 ms ms NNP cord-028530-hpgrbhkl 26 13 or or CC cord-028530-hpgrbhkl 26 14 an an DT cord-028530-hpgrbhkl 26 15 increase increase NN cord-028530-hpgrbhkl 26 16 greater great JJR cord-028530-hpgrbhkl 26 17 than than IN cord-028530-hpgrbhkl 26 18 or or CC cord-028530-hpgrbhkl 26 19 equal equal JJ cord-028530-hpgrbhkl 26 20 to to IN cord-028530-hpgrbhkl 26 21 60 60 CD cord-028530-hpgrbhkl 26 22 ░ ░ NNP cord-028530-hpgrbhkl 26 23 ms ms NNP cord-028530-hpgrbhkl 26 24 is be VBZ cord-028530-hpgrbhkl 26 25 observed observe VBN cord-028530-hpgrbhkl 26 26 , , , cord-028530-hpgrbhkl 26 27 treatment treatment NN cord-028530-hpgrbhkl 26 28 should should MD cord-028530-hpgrbhkl 26 29 be be VB cord-028530-hpgrbhkl 26 30 discontinued discontinue VBN cord-028530-hpgrbhkl 26 31 4 4 CD cord-028530-hpgrbhkl 26 32 . . . cord-028530-hpgrbhkl 27 1 -Avoid -Avoid : cord-028530-hpgrbhkl 27 2 or or CC cord-028530-hpgrbhkl 27 3 discontinue discontinue VB cord-028530-hpgrbhkl 27 4 the the DT cord-028530-hpgrbhkl 27 5 simultaneous simultaneous JJ cord-028530-hpgrbhkl 27 6 use use NN cord-028530-hpgrbhkl 27 7 of of IN cord-028530-hpgrbhkl 27 8 drugs drug NNS cord-028530-hpgrbhkl 27 9 that that WDT cord-028530-hpgrbhkl 27 10 prolong prolong VBP cord-028530-hpgrbhkl 27 11 the the DT cord-028530-hpgrbhkl 27 12 QTc QTc NNS cord-028530-hpgrbhkl 27 13 , , , cord-028530-hpgrbhkl 27 14 particularly particularly RB cord-028530-hpgrbhkl 27 15 azithromycin azithromycin NNP cord-028530-hpgrbhkl 27 16 , , , cord-028530-hpgrbhkl 27 17 clarithromycin clarithromycin NNP cord-028530-hpgrbhkl 27 18 , , , cord-028530-hpgrbhkl 27 19 levofloxacin levofloxacin NNP cord-028530-hpgrbhkl 27 20 , , , cord-028530-hpgrbhkl 27 21 moxifloxacin moxifloxacin NNS cord-028530-hpgrbhkl 27 22 , , , cord-028530-hpgrbhkl 27 23 ciprofloxacin ciprofloxacin NN cord-028530-hpgrbhkl 27 24 , , , cord-028530-hpgrbhkl 27 25 haloperidol haloperidol NNP cord-028530-hpgrbhkl 27 26 , , , cord-028530-hpgrbhkl 27 27 quetiapine quetiapine NNP cord-028530-hpgrbhkl 27 28 , , , cord-028530-hpgrbhkl 27 29 risperidone risperidone NN cord-028530-hpgrbhkl 27 30 , , , cord-028530-hpgrbhkl 27 31 domperidone domperidone NNP cord-028530-hpgrbhkl 27 32 and and CC cord-028530-hpgrbhkl 27 33 ondansetron ondansetron NN cord-028530-hpgrbhkl 27 34 , , , cord-028530-hpgrbhkl 27 35 among among IN cord-028530-hpgrbhkl 27 36 others other NNS cord-028530-hpgrbhkl 27 37 4,5 4,5 CD cord-028530-hpgrbhkl 27 38 . . . cord-028530-hpgrbhkl 28 1 -Keep -Keep . cord-028530-hpgrbhkl 29 1 a a DT cord-028530-hpgrbhkl 29 2 close close JJ cord-028530-hpgrbhkl 29 3 watch watch NN cord-028530-hpgrbhkl 29 4 on on IN cord-028530-hpgrbhkl 29 5 potassium potassium NN cord-028530-hpgrbhkl 29 6 , , , cord-028530-hpgrbhkl 29 7 calcium calcium NN cord-028530-hpgrbhkl 29 8 and and CC cord-028530-hpgrbhkl 29 9 magnesium magnesium NN cord-028530-hpgrbhkl 29 10 levels level NNS cord-028530-hpgrbhkl 29 11 due due IN cord-028530-hpgrbhkl 29 12 to to IN cord-028530-hpgrbhkl 29 13 their -PRON- PRP$ cord-028530-hpgrbhkl 29 14 arrhythmogenic arrhythmogenic JJ cord-028530-hpgrbhkl 29 15 potential potential NN cord-028530-hpgrbhkl 29 16 , , , cord-028530-hpgrbhkl 29 17 as as RB cord-028530-hpgrbhkl 29 18 well well RB cord-028530-hpgrbhkl 29 19 as as IN cord-028530-hpgrbhkl 29 20 glycemia glycemia NN cord-028530-hpgrbhkl 29 21 in in IN cord-028530-hpgrbhkl 29 22 patients patient NNS cord-028530-hpgrbhkl 29 23 with with IN cord-028530-hpgrbhkl 29 24 diabetes diabete NNS cord-028530-hpgrbhkl 29 25 due due IN cord-028530-hpgrbhkl 29 26 to to IN cord-028530-hpgrbhkl 29 27 the the DT cord-028530-hpgrbhkl 29 28 risk risk NN cord-028530-hpgrbhkl 29 29 of of IN cord-028530-hpgrbhkl 29 30 hypoglycemia hypoglycemia NN cord-028530-hpgrbhkl 29 31 4 4 CD cord-028530-hpgrbhkl 29 32 . . . cord-028530-hpgrbhkl 30 1 -Consider -Consider : cord-028530-hpgrbhkl 30 2 not not RB cord-028530-hpgrbhkl 30 3 administering administer VBG cord-028530-hpgrbhkl 30 4 or or CC cord-028530-hpgrbhkl 30 5 discontinuing discontinue VBG cord-028530-hpgrbhkl 30 6 HCQ HCQ NNP cord-028530-hpgrbhkl 30 7 in in IN cord-028530-hpgrbhkl 30 8 advanced advanced JJ cord-028530-hpgrbhkl 30 9 stages stage NNS cord-028530-hpgrbhkl 30 10 of of IN cord-028530-hpgrbhkl 30 11 infection infection NN cord-028530-hpgrbhkl 30 12 due due IN cord-028530-hpgrbhkl 30 13 to to IN cord-028530-hpgrbhkl 30 14 the the DT cord-028530-hpgrbhkl 30 15 possibility possibility NN cord-028530-hpgrbhkl 30 16 of of IN cord-028530-hpgrbhkl 30 17 a a DT cord-028530-hpgrbhkl 30 18 COVID-19-induced COVID-19-induced NNP cord-028530-hpgrbhkl 30 19 myocarditis myocarditis NN cord-028530-hpgrbhkl 30 20 3,5 3,5 CD cord-028530-hpgrbhkl 30 21 . . . cord-028530-hpgrbhkl 31 1 -It -It : cord-028530-hpgrbhkl 31 2 is be VBZ cord-028530-hpgrbhkl 31 3 not not RB cord-028530-hpgrbhkl 31 4 necessary necessary JJ cord-028530-hpgrbhkl 31 5 to to TO cord-028530-hpgrbhkl 31 6 adjust adjust VB cord-028530-hpgrbhkl 31 7 the the DT cord-028530-hpgrbhkl 31 8 dose dose NN cord-028530-hpgrbhkl 31 9 based base VBN cord-028530-hpgrbhkl 31 10 on on IN cord-028530-hpgrbhkl 31 11 renal renal JJ cord-028530-hpgrbhkl 31 12 or or CC cord-028530-hpgrbhkl 31 13 hepatic hepatic JJ cord-028530-hpgrbhkl 31 14 function function NN cord-028530-hpgrbhkl 31 15 , , , cord-028530-hpgrbhkl 31 16 nor nor CC cord-028530-hpgrbhkl 31 17 does do VBZ cord-028530-hpgrbhkl 31 18 it -PRON- PRP cord-028530-hpgrbhkl 31 19 require require VB cord-028530-hpgrbhkl 31 20 ophthalmological ophthalmological JJ cord-028530-hpgrbhkl 31 21 control control NN cord-028530-hpgrbhkl 31 22 before before IN cord-028530-hpgrbhkl 31 23 or or CC cord-028530-hpgrbhkl 31 24 after after IN cord-028530-hpgrbhkl 31 25 treatment treatment NN cord-028530-hpgrbhkl 31 26 6 6 CD cord-028530-hpgrbhkl 31 27 . . . cord-028530-hpgrbhkl 32 1 -Pending -pende VBG cord-028530-hpgrbhkl 32 2 the the DT cord-028530-hpgrbhkl 32 3 result result NN cord-028530-hpgrbhkl 32 4 of of IN cord-028530-hpgrbhkl 32 5 several several JJ cord-028530-hpgrbhkl 32 6 active active JJ cord-028530-hpgrbhkl 32 7 studies study NNS cord-028530-hpgrbhkl 32 8 , , , cord-028530-hpgrbhkl 32 9 HCQ HCQ NNP cord-028530-hpgrbhkl 32 10 should should MD cord-028530-hpgrbhkl 32 11 not not RB cord-028530-hpgrbhkl 32 12 be be VB cord-028530-hpgrbhkl 32 13 indicated indicate VBN cord-028530-hpgrbhkl 32 14 prophylactically prophylactically RB cord-028530-hpgrbhkl 32 15 as as IN cord-028530-hpgrbhkl 32 16 there there EX cord-028530-hpgrbhkl 32 17 is be VBZ cord-028530-hpgrbhkl 32 18 no no DT cord-028530-hpgrbhkl 32 19 evidence evidence NN cord-028530-hpgrbhkl 32 20 to to TO cord-028530-hpgrbhkl 32 21 support support VB cord-028530-hpgrbhkl 32 22 its -PRON- PRP$ cord-028530-hpgrbhkl 32 23 preventive preventive JJ cord-028530-hpgrbhkl 32 24 use use NN cord-028530-hpgrbhkl 32 25 or or CC cord-028530-hpgrbhkl 32 26 postexposure postexposure NN cord-028530-hpgrbhkl 32 27 to to TO cord-028530-hpgrbhkl 32 28 avoid avoid VB cord-028530-hpgrbhkl 32 29 COVID-19 covid-19 JJ cord-028530-hpgrbhkl 32 30 infection infection NN cord-028530-hpgrbhkl 32 31 . . . cord-028530-hpgrbhkl 33 1 In in IN cord-028530-hpgrbhkl 33 2 short short JJ cord-028530-hpgrbhkl 33 3 , , , cord-028530-hpgrbhkl 33 4 when when WRB cord-028530-hpgrbhkl 33 5 prescribing prescribe VBG cord-028530-hpgrbhkl 33 6 HCQ HCQ NNP cord-028530-hpgrbhkl 33 7 in in IN cord-028530-hpgrbhkl 33 8 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 33 9 , , , cord-028530-hpgrbhkl 33 10 different different JJ cord-028530-hpgrbhkl 33 11 precautions precaution NNS cord-028530-hpgrbhkl 33 12 should should MD cord-028530-hpgrbhkl 33 13 be be VB cord-028530-hpgrbhkl 33 14 taken take VBN cord-028530-hpgrbhkl 33 15 from from IN cord-028530-hpgrbhkl 33 16 those those DT cord-028530-hpgrbhkl 33 17 currently currently RB cord-028530-hpgrbhkl 33 18 considered consider VBN cord-028530-hpgrbhkl 33 19 for for IN cord-028530-hpgrbhkl 33 20 SLE SLE NNP cord-028530-hpgrbhkl 33 21 patients patient NNS cord-028530-hpgrbhkl 33 22 . . . cord-028530-hpgrbhkl 34 1 It -PRON- PRP cord-028530-hpgrbhkl 34 2 should should MD cord-028530-hpgrbhkl 34 3 be be VB cord-028530-hpgrbhkl 34 4 indicated indicate VBN cord-028530-hpgrbhkl 34 5 in in IN cord-028530-hpgrbhkl 34 6 its -PRON- PRP$ cord-028530-hpgrbhkl 34 7 window window NN cord-028530-hpgrbhkl 34 8 of of IN cord-028530-hpgrbhkl 34 9 opportunity opportunity NN cord-028530-hpgrbhkl 34 10 and and CC cord-028530-hpgrbhkl 34 11 consider consider VB cord-028530-hpgrbhkl 34 12 the the DT cord-028530-hpgrbhkl 34 13 existing exist VBG cord-028530-hpgrbhkl 34 14 multifactorial multifactorial JJ cord-028530-hpgrbhkl 34 15 myocardial myocardial JJ cord-028530-hpgrbhkl 34 16 involvement involvement NN cord-028530-hpgrbhkl 34 17 , , , cord-028530-hpgrbhkl 34 18 seeking seek VBG cord-028530-hpgrbhkl 34 19 to to TO cord-028530-hpgrbhkl 34 20 avoid avoid VB cord-028530-hpgrbhkl 34 21 cardiovascular cardiovascular JJ cord-028530-hpgrbhkl 34 22 adverse adverse JJ cord-028530-hpgrbhkl 34 23 effects effect NNS cord-028530-hpgrbhkl 34 24 . . . cord-028530-hpgrbhkl 35 1 The the DT cord-028530-hpgrbhkl 35 2 results result NNS cord-028530-hpgrbhkl 35 3 of of IN cord-028530-hpgrbhkl 35 4 different different JJ cord-028530-hpgrbhkl 35 5 controlled control VBN cord-028530-hpgrbhkl 35 6 and and CC cord-028530-hpgrbhkl 35 7 J J NNP cord-028530-hpgrbhkl 35 8 o o NN cord-028530-hpgrbhkl 35 9 u u NN cord-028530-hpgrbhkl 35 10 r r NN cord-028530-hpgrbhkl 35 11 n n NN cord-028530-hpgrbhkl 35 12 a a DT cord-028530-hpgrbhkl 35 13 l l NN cord-028530-hpgrbhkl 35 14 P p NN cord-028530-hpgrbhkl 35 15 r r NN cord-028530-hpgrbhkl 35 16 e e NN cord-028530-hpgrbhkl 35 17 -p -p NN cord-028530-hpgrbhkl 35 18 r r NN cord-028530-hpgrbhkl 35 19 o o NN cord-028530-hpgrbhkl 35 20 o o NN cord-028530-hpgrbhkl 35 21 f f NN cord-028530-hpgrbhkl 35 22 randomized randomized JJ cord-028530-hpgrbhkl 35 23 studies study NNS cord-028530-hpgrbhkl 35 24 that that WDT cord-028530-hpgrbhkl 35 25 confirm confirm VBP cord-028530-hpgrbhkl 35 26 or or CC cord-028530-hpgrbhkl 35 27 refute refute VB cord-028530-hpgrbhkl 35 28 the the DT cord-028530-hpgrbhkl 35 29 usefulness usefulness NN cord-028530-hpgrbhkl 35 30 of of IN cord-028530-hpgrbhkl 35 31 HCQ HCQ NNP cord-028530-hpgrbhkl 35 32 in in IN cord-028530-hpgrbhkl 35 33 the the DT cord-028530-hpgrbhkl 35 34 treatment treatment NN cord-028530-hpgrbhkl 35 35 of of IN cord-028530-hpgrbhkl 35 36 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 35 37 will will MD cord-028530-hpgrbhkl 35 38 contribute contribute VB cord-028530-hpgrbhkl 35 39 to to TO cord-028530-hpgrbhkl 35 40 define define VB cord-028530-hpgrbhkl 35 41 its -PRON- PRP$ cord-028530-hpgrbhkl 35 42 role role NN cord-028530-hpgrbhkl 35 43 in in IN cord-028530-hpgrbhkl 35 44 this this DT cord-028530-hpgrbhkl 35 45 clinical clinical JJ cord-028530-hpgrbhkl 35 46 setting setting NN cord-028530-hpgrbhkl 35 47 . . . cord-028530-hpgrbhkl 36 1 The the DT cord-028530-hpgrbhkl 36 2 authors author NNS cord-028530-hpgrbhkl 36 3 declare declare VBP cord-028530-hpgrbhkl 36 4 that that IN cord-028530-hpgrbhkl 36 5 they -PRON- PRP cord-028530-hpgrbhkl 36 6 have have VBP cord-028530-hpgrbhkl 36 7 not not RB cord-028530-hpgrbhkl 36 8 received receive VBN cord-028530-hpgrbhkl 36 9 funding funding NN cord-028530-hpgrbhkl 36 10 to to TO cord-028530-hpgrbhkl 36 11 carry carry VB cord-028530-hpgrbhkl 36 12 out out RP cord-028530-hpgrbhkl 36 13 this this DT cord-028530-hpgrbhkl 36 14 study study NN cord-028530-hpgrbhkl 36 15 . . . cord-028530-hpgrbhkl 37 1 Uso Uso NNP cord-028530-hpgrbhkl 37 2 de de IN cord-028530-hpgrbhkl 37 3 antipalúdicos antipalúdicos NNP cord-028530-hpgrbhkl 37 4 en en IN cord-028530-hpgrbhkl 37 5 el el NNP cord-028530-hpgrbhkl 37 6 tratamiento tratamiento NNP cord-028530-hpgrbhkl 37 7 del del NNP cord-028530-hpgrbhkl 38 1 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 38 2 : : : cord-028530-hpgrbhkl 38 3 una una NNP cord-028530-hpgrbhkl 38 4 ventana ventana NNP cord-028530-hpgrbhkl 38 5 de de NNP cord-028530-hpgrbhkl 38 6 oportunidad oportunidad NNP cord-028530-hpgrbhkl 38 7 ? ? . cord-028530-hpgrbhkl 39 1 Antimalarialinduced antimalarialinduced JJ cord-028530-hpgrbhkl 39 2 cardiomyopathy cardiomyopathy NN cord-028530-hpgrbhkl 39 3 : : : cord-028530-hpgrbhkl 39 4 a a DT cord-028530-hpgrbhkl 39 5 systematic systematic JJ cord-028530-hpgrbhkl 39 6 review review NN cord-028530-hpgrbhkl 39 7 of of IN cord-028530-hpgrbhkl 39 8 the the DT cord-028530-hpgrbhkl 39 9 literature literature NN cord-028530-hpgrbhkl 39 10 Cardiovascular cardiovascular JJ cord-028530-hpgrbhkl 39 11 complications complication NNS cord-028530-hpgrbhkl 39 12 in in IN cord-028530-hpgrbhkl 39 13 patients patient NNS cord-028530-hpgrbhkl 39 14 with with IN cord-028530-hpgrbhkl 39 15 COVID-19 covid-19 NN cord-028530-hpgrbhkl 39 16 : : : cord-028530-hpgrbhkl 39 17 consequences consequence NNS cord-028530-hpgrbhkl 39 18 of of IN cord-028530-hpgrbhkl 39 19 viral viral JJ cord-028530-hpgrbhkl 39 20 toxicities toxicity NNS cord-028530-hpgrbhkl 39 21 and and CC cord-028530-hpgrbhkl 39 22 host host NN cord-028530-hpgrbhkl 39 23 immune immune JJ cord-028530-hpgrbhkl 39 24 response response NN cord-028530-hpgrbhkl 39 25 Guidance guidance NN cord-028530-hpgrbhkl 39 26 of of IN cord-028530-hpgrbhkl 39 27 minimizing minimize VBG cord-028530-hpgrbhkl 39 28 risk risk NN cord-028530-hpgrbhkl 39 29 of of IN cord-028530-hpgrbhkl 39 30 druginduced druginduced JJ cord-028530-hpgrbhkl 39 31 ventricular ventricular JJ cord-028530-hpgrbhkl 39 32 arrhytmia arrhytmia NN cord-028530-hpgrbhkl 39 33 during during IN cord-028530-hpgrbhkl 39 34 treatment treatment NN cord-028530-hpgrbhkl 39 35 of of IN cord-028530-hpgrbhkl 39 36 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 39 37 : : : cord-028530-hpgrbhkl 39 38 a a DT cord-028530-hpgrbhkl 39 39 statement statement NN cord-028530-hpgrbhkl 39 40 from from IN cord-028530-hpgrbhkl 39 41 the the DT cord-028530-hpgrbhkl 39 42 Canadian canadian JJ cord-028530-hpgrbhkl 39 43 heart heart NN cord-028530-hpgrbhkl 39 44 rhythm rhythm NN cord-028530-hpgrbhkl 39 45 Society Society NNP cord-028530-hpgrbhkl 39 46 Description Description NNP cord-028530-hpgrbhkl 39 47 and and CC cord-028530-hpgrbhkl 39 48 proposed propose VBN cord-028530-hpgrbhkl 39 49 management management NN cord-028530-hpgrbhkl 39 50 of of IN cord-028530-hpgrbhkl 39 51 the the DT cord-028530-hpgrbhkl 39 52 acute acute JJ cord-028530-hpgrbhkl 39 53 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 39 54 cardiovascular cardiovascular JJ cord-028530-hpgrbhkl 39 55 syndrome syndrome NN cord-028530-hpgrbhkl 39 56 COVID-19 COVID-19 NNP cord-028530-hpgrbhkl 39 57 and and CC cord-028530-hpgrbhkl 39 58 chloroquine chloroquine NNP cord-028530-hpgrbhkl 39 59 / / SYM cord-028530-hpgrbhkl 39 60 hydroxychloroquine hydroxychloroquine NN cord-028530-hpgrbhkl 39 61 : : : cord-028530-hpgrbhkl 39 62 is be VBZ cord-028530-hpgrbhkl 39 63 there there EX cord-028530-hpgrbhkl 39 64 ophthalmological ophthalmological JJ cord-028530-hpgrbhkl 39 65 concern concern NN cord-028530-hpgrbhkl 39 66 ? ? .