id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347775-hidb8q1u	Karatza, Eleni	Optimization of hydroxychloroquine dosing scheme based on COVID-19 patients’ characteristics: a review of the literature and simulations	2020-09-30		.txt	text/plain	5968	300	54	Model-based simulations of HCQ concentrations revealed that high initial doses followed by low and sparse doses may offer significant benefits to patients by decreasing the viral load without reaching levels considered to produce adverse effects. 4. Based on the results from simulations performed and the currently published knowledge regarding HCQ in COVID-19 treatment, this study provides evidence that a high loading dose followed by sparse doses could offer significant benefits to the patients. Dosing schemes were designed in order to achieve a fast onset of "high" concentrations during the initial phase of the disease, since an initial higher viral load is anticipated, especially for patients with severe COVID-19, and then keep HCQ blood levels below 2250 ng/ml and over 500 ng/ml, at all times.	./cache/cord-347775-hidb8q1u.txt	./txt/cord-347775-hidb8q1u.txt