id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318092-errwp80i	Ren, L.	Assessment of Hydroxychloroquine and Chloroquine Safety Profiles: A Systematic Review and Meta-Analysis	2020-05-08		.txt	text/plain	5938	371	58	Methods: We systematically searched PubMed, MEDLINE, Cochrane, the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, and the ClinicalTrials.gov for all the RCTs comparing CQ or HCQ with placebo or other active agents, published before March 31, 2020. Our objective was to identify all randomized clinical trials (RCTs) that compared the safety profiles of chloroquine or hydroxychloroquine with placebo or other active agents. This review was not restricted to studies conducted in the English language; it includes reports from any countries that compared CQ or HCQ with placebo or other active agents, since there is a wealth of information in RCTs from many different countries. Together, these stratified data provide ample information regarding the percentage of participants who experienced specific AEs. Subgroup meta-analysis for CQ and HCQ with respect to age, duration, and dosage. For HCQ, there was no evidence that age, duration of trial, or dosage affected total AEs. Further meta-regression analyses can be found in Supplementary Figure 1 .	./cache/cord-318092-errwp80i.txt	./txt/cord-318092-errwp80i.txt