id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252586-fuaoelgb	Phillips, Sandra	Alisporivir Inhibition of Hepatocyte Cyclophilins Reduces HBV Replication and Hepatitis B Surface Antigen Production	2014-10-08		.txt	text/plain	5530	296	47	METHODS: Liver-derived cell lines producing full-length HBV and HBsAg particles, owing to stable (HepG2215) or transient (HuH-7) transfection, or infected with HBV (HepaRG cells; Invitrogen [Carlsbad, CA]), were incubated with alisporivir or NIM811 alone, or alisporivir in combination with a direct antiviral (telbivudine). Alisporivir treatment of HepG2215 cells resulted in a progressive reduction of secreted and intracellular, nucleocapsid-associated HBV DNA dependent on both drug concentration and time of drug exposure ( Figure 1A and B). NIM811 treatment of HepG2215 and of HepaRG cells also reduced the secreted and intracellular nucleocapsidassociated HBV DNA, however, its antiviral effect was lower than alisporivir (Supplementary Figure 3) . As stated earlier, alisporivir at 5 mg/mL reduced intracellular HBV-DNA levels by 73% and 58% in HuH-7 and HepG2215 cells, respectively, after 72 hours of treatment ( Figure 1B and D) .	./cache/cord-252586-fuaoelgb.txt	./txt/cord-252586-fuaoelgb.txt