id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349720-2lxab3u2	Qin, Ling	Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits	2015-05-15		.txt	text/plain	9960	525	52	Poly lactic-co-glycolic acid/tricalcium phosphate (P/T) scaffold providing sustained release of icaritin (a metabolite of Epimedium-derived flavonoids) was investigated as a bone defect filler after surgical core-decompression (CD) to prevent femoral head collapse in a bipedal SAON animal model using emu (a large flightless bird). In conclusion, both efficacy and mechanistic studies show the potential of a bioactive composite porous P/T scaffold incorporating icaritin to enhance bone defect repair after surgical CD and prevent femoral head collapse in a bipedal SAON emu model. Applying a recently established bipedal emu SAON model with femoral head collapse similar to that typically observed in patients [23] , this study was designed to test the ability of our unique PLGA/ TCP/icaritin scaffold to enhance bone defect repair within a bone tunnel after surgical CD and to prevent femoral head collapse.	./cache/cord-349720-2lxab3u2.txt	./txt/cord-349720-2lxab3u2.txt