id author title date pages extension mime words sentences flesch summary cache txt cord-344121-k58c0jf3 Lundgren, A.-L. Neurological disease and encephalitis in cats experimentally infected with Borna disease virus 1997 .txt text/plain 6161 340 52 Barrier-bred cats were inoculated intracerebrally with either the rabbit-adapted Borna disease virus (BDV) strain V or a newly isolated feline BDV, obtained from a cat with natural staggering disease (SD). Using immunohistochemistry and a reverse transcriptase-polymerase chain reaction assay, BDV-specific antigen and nucleic acid could be demonstrated in brain samples from each cat with encephalitis, showing that incomplete viral clearance was probably responsible for the maintenance of inflammation. The successful induction of neurological signs and encephalitis in one cat infected with feline BDV, together with the detection of BDV-specific antigen and nucleic acid in the brain, provides strong evidence for the notion that BDV is the etiological agent behind feline SD. Of the cats in group II (cats inoculated with feline BDV), cat 6 had a few antigen-containing neurons and glial cells in the laterobasal temporal cortex, close to a region with several adventitial cuffs. ./cache/cord-344121-k58c0jf3.txt ./txt/cord-344121-k58c0jf3.txt