id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341397-gl8xzzdv	Bhavani, Sivasubramanium V.	Novel Temperature Trajectory Subphenotypes in COVID-19	2020-07-21		.txt	text/plain	1395	93	44	In contrast to other common viral infections, COVID-19 presents unique challenges with high rates of hypoxemic respiratory failure, hyperinflammatory cytokine storm, coagulation abnormalities, and cardiac and renal dysfunction 2, 3 . We have previously published a novel method of identifying subphenotypes in hospitalized patients with all-cause infection using longitudinal body temperature measurements 6 . We hypothesize that using a similar approach specific to COVID-19 patients would identify subphenotypes with unique clinical characteristics and inflammatory and coagulation abnormalities. The primary outcome was 30-day inpatient mortality, which was modeled on subphenotype using Cox regression analysis, controlling for demographics, comorbidities, and severity of illness. The high mortality rate seen in Group 1 and the organ dysfunction seen in Group 4 suggest that both subphenotypes have a dysregulated response to COVID-19. In conclusion, we found four distinct subphenotypes of COVID-19 patients with markedly different clinical characteristics and mortality rates.	./cache/cord-341397-gl8xzzdv.txt	./txt/cord-341397-gl8xzzdv.txt