id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012537-49v45di6	El-Ghandour, Mamdouh	Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial	2020-08-28		.txt	text/plain	2825	152	46	title: Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial OBJECTIVES: The current study aimed to investigate the efficacy of oral sildenafil and intravenous milrinone infusion and compare the effects of these drugs in combination versus as monotherapy in neonates with PPHN. In newborn care units lacking this gold standard therapy for PPHN, treatment comprises pulmonary vasodilators such as oral sildenafil or continuous intravenous infusion of milrinone. In the current randomized controlled trial, sildenafil combined with milrinone was more effective at normalizing pulmonary artery pressure and improving survival rates than treatment with either of the two drugs as monotherapy. Results from the current study showed that the combination of oral sildenafil and intravenous milrinone resulted in improved clinical outcomes, reflected by reduced mortality and a significant decrease in PASP.	./cache/cord-012537-49v45di6.txt	./txt/cord-012537-49v45di6.txt