id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003913-jr9hj0bs	Park, Hyeong-Jun	Comprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant	2019-09-07		.txt	text/plain	7537	429	53	Furthermore, poly I:C induced higher pro-inflammatory cytokines than those of ssRNA nanostructure adjuvant in RAW 264.7 cells, which are a mouse macrophage cell line ( Figure S3 , detailed in supplementary methods), indicating poly I:C may stimulate a stronger inflammation response compared to that of the ssRNA nano-structure adjuvant. Not only the liver, which is a typical organ studied to assess toxicity, but also the lungs, kidneys, injection sites, and immune-related organs (spleen and thymus) were stained with H + E to observe local and systemic toxicity, including cellular damage and inflammatory cell infiltration, associated with the ssRNA nano-structure adjuvant (Figure 4 ). Not only the liver, which is a typical organ studied to assess toxicity, but also the lungs, kidneys, injection sites, and immune-related organs (spleen and thymus) were stained with H + E to observe local and systemic toxicity, including cellular damage and inflammatory cell infiltration, associated with the ssRNA nano-structure adjuvant (Figure 4 ).	./cache/cord-003913-jr9hj0bs.txt	./txt/cord-003913-jr9hj0bs.txt