id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003673-u7711eb4	Xiong, Xiao-Li	Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile	2019-05-22		.txt	text/plain	6866	470	61	Real-time PCR and Western blotting was employed to detect the mRNA and protein levels of BSEP in LO2 cell, rat primary hepatocytes and liver tissue. More importantly, our previous work revealed that emodin could alleviate intrahepatic cholestasis by promoting the expression of liver farnesoid X receptor (FXR), small heterodimer partner (SHP), uridine diphosphate glucuronosyltransferase 2 family polypeptide B4 (UGT2B4), and bile salt export pump (BSEP), which are related to the synthesis, detoxification, and transportation process of Bas (Ding et al., 2016) . Therefore, this research used the LO2 cell line and ANIT-induced rat model to find how emodin interfered with the BSEP signaling pathway to alleviate intrahepatic cholestasis. As shown in Figure 8D , compared with the untreated cells, the emodin group showed significantly elevated mRNA levels of FXR and BSEP. For the LO2 cell experiment, the mRNA and protein expressions of FXR and BSEP were significantly elevated in the emodin group compared with control group.	./cache/cord-003673-u7711eb4.txt	./txt/cord-003673-u7711eb4.txt