id sid tid token lemma pos cord-326015-ky4y2xjt 1 1 key key JJ cord-326015-ky4y2xjt 1 2 : : : cord-326015-ky4y2xjt 1 3 cord-326015-ky4y2xjt cord-326015-ky4y2xjt JJ cord-326015-ky4y2xjt 1 4 authors author NNS cord-326015-ky4y2xjt 1 5 : : : cord-326015-ky4y2xjt 1 6 Füllekrug Füllekrug NNP cord-326015-ky4y2xjt 1 7 , , , cord-326015-ky4y2xjt 1 8 Joachim Joachim NNP cord-326015-ky4y2xjt 1 9 ; ; : cord-326015-ky4y2xjt 1 10 Nilsson Nilsson NNP cord-326015-ky4y2xjt 1 11 , , , cord-326015-ky4y2xjt 1 12 Tommy Tommy NNP cord-326015-ky4y2xjt 2 1 title title NN cord-326015-ky4y2xjt 2 2 : : : cord-326015-ky4y2xjt 2 3 Protein protein NN cord-326015-ky4y2xjt 2 4 sorting sorting NN cord-326015-ky4y2xjt 2 5 in in IN cord-326015-ky4y2xjt 2 6 the the DT cord-326015-ky4y2xjt 2 7 Golgi Golgi NNP cord-326015-ky4y2xjt 2 8 complex complex JJ cord-326015-ky4y2xjt 2 9 date date NN cord-326015-ky4y2xjt 2 10 : : : cord-326015-ky4y2xjt 2 11 1998 1998 CD cord-326015-ky4y2xjt 2 12 - - SYM cord-326015-ky4y2xjt 2 13 08 08 CD cord-326015-ky4y2xjt 2 14 - - SYM cord-326015-ky4y2xjt 2 15 14 14 CD cord-326015-ky4y2xjt 2 16 journal journal NN cord-326015-ky4y2xjt 2 17 : : : cord-326015-ky4y2xjt 3 1 Biochim Biochim NNP cord-326015-ky4y2xjt 3 2 Biophys Biophys NNP cord-326015-ky4y2xjt 3 3 Acta Acta NNP cord-326015-ky4y2xjt 3 4 Mol Mol NNP cord-326015-ky4y2xjt 3 5 Cell cell NN cord-326015-ky4y2xjt 3 6 Res res NN cord-326015-ky4y2xjt 3 7 DOI doi NN cord-326015-ky4y2xjt 3 8 : : : cord-326015-ky4y2xjt 4 1 10.1016 10.1016 CD cord-326015-ky4y2xjt 4 2 / / SYM cord-326015-ky4y2xjt 4 3 s0167 s0167 CD cord-326015-ky4y2xjt 4 4 - - HYPH cord-326015-ky4y2xjt 4 5 4889(98)00048 4889(98)00048 CD cord-326015-ky4y2xjt 4 6 - - HYPH cord-326015-ky4y2xjt 4 7 2 2 CD cord-326015-ky4y2xjt 4 8 sha sha NNP cord-326015-ky4y2xjt 4 9 : : : cord-326015-ky4y2xjt 4 10 1b1d99b4ffc25a1c74d8db98063c690dd02a8e2c 1b1d99b4ffc25a1c74d8db98063c690dd02a8e2c CD cord-326015-ky4y2xjt 4 11 doc_id doc_id CD cord-326015-ky4y2xjt 4 12 : : : cord-326015-ky4y2xjt 4 13 326015 326015 CD cord-326015-ky4y2xjt 4 14 cord_uid cord_uid NNS cord-326015-ky4y2xjt 4 15 : : : cord-326015-ky4y2xjt 4 16 ky4y2xjt ky4y2xjt XX cord-326015-ky4y2xjt 4 17 Even even RB cord-326015-ky4y2xjt 4 18 after after IN cord-326015-ky4y2xjt 4 19 one one CD cord-326015-ky4y2xjt 4 20 hundred hundred CD cord-326015-ky4y2xjt 4 21 years year NNS cord-326015-ky4y2xjt 4 22 , , , cord-326015-ky4y2xjt 4 23 the the DT cord-326015-ky4y2xjt 4 24 Golgi Golgi NNP cord-326015-ky4y2xjt 4 25 apparatus apparatus NN cord-326015-ky4y2xjt 4 26 remains remain VBZ cord-326015-ky4y2xjt 4 27 a a DT cord-326015-ky4y2xjt 4 28 major major JJ cord-326015-ky4y2xjt 4 29 challenge challenge NN cord-326015-ky4y2xjt 4 30 in in IN cord-326015-ky4y2xjt 4 31 the the DT cord-326015-ky4y2xjt 4 32 field field NN cord-326015-ky4y2xjt 4 33 of of IN cord-326015-ky4y2xjt 4 34 Cell Cell NNP cord-326015-ky4y2xjt 4 35 Biology Biology NNP cord-326015-ky4y2xjt 4 36 . . . cord-326015-ky4y2xjt 5 1 This this DT cord-326015-ky4y2xjt 5 2 is be VBZ cord-326015-ky4y2xjt 5 3 particularly particularly RB cord-326015-ky4y2xjt 5 4 true true JJ cord-326015-ky4y2xjt 5 5 in in IN cord-326015-ky4y2xjt 5 6 terms term NNS cord-326015-ky4y2xjt 5 7 of of IN cord-326015-ky4y2xjt 5 8 transport transport NN cord-326015-ky4y2xjt 5 9 and and CC cord-326015-ky4y2xjt 5 10 of of IN cord-326015-ky4y2xjt 5 11 protein protein NN cord-326015-ky4y2xjt 5 12 sorting sorting NN cord-326015-ky4y2xjt 5 13 . . . cord-326015-ky4y2xjt 6 1 For for IN cord-326015-ky4y2xjt 6 2 example example NN cord-326015-ky4y2xjt 6 3 , , , cord-326015-ky4y2xjt 6 4 the the DT cord-326015-ky4y2xjt 6 5 question question NN cord-326015-ky4y2xjt 6 6 how how WRB cord-326015-ky4y2xjt 6 7 cargo cargo NN cord-326015-ky4y2xjt 6 8 proteins protein NNS cord-326015-ky4y2xjt 6 9 are be VBP cord-326015-ky4y2xjt 6 10 transported transport VBN cord-326015-ky4y2xjt 6 11 through through IN cord-326015-ky4y2xjt 6 12 this this DT cord-326015-ky4y2xjt 6 13 organelle organelle NN cord-326015-ky4y2xjt 6 14 is be VBZ cord-326015-ky4y2xjt 6 15 still still RB cord-326015-ky4y2xjt 6 16 a a DT cord-326015-ky4y2xjt 6 17 matter matter NN cord-326015-ky4y2xjt 6 18 of of IN cord-326015-ky4y2xjt 6 19 debate debate NN cord-326015-ky4y2xjt 6 20 . . . cord-326015-ky4y2xjt 7 1 Emphasis emphasis NN cord-326015-ky4y2xjt 7 2 has have VBZ cord-326015-ky4y2xjt 7 3 been be VBN cord-326015-ky4y2xjt 7 4 put put VBN cord-326015-ky4y2xjt 7 5 on on IN cord-326015-ky4y2xjt 7 6 the the DT cord-326015-ky4y2xjt 7 7 role role NN cord-326015-ky4y2xjt 7 8 of of IN cord-326015-ky4y2xjt 7 9 anterograde anterograde JJ cord-326015-ky4y2xjt 7 10 and and CC cord-326015-ky4y2xjt 7 11 retrograde retrograde JJ cord-326015-ky4y2xjt 7 12 transport transport NN cord-326015-ky4y2xjt 7 13 vesicles vesicle NNS cord-326015-ky4y2xjt 7 14 . . . cord-326015-ky4y2xjt 8 1 These these DT cord-326015-ky4y2xjt 8 2 have have VBP cord-326015-ky4y2xjt 8 3 been be VBN cord-326015-ky4y2xjt 8 4 proposed propose VBN cord-326015-ky4y2xjt 8 5 to to TO cord-326015-ky4y2xjt 8 6 carry carry VB cord-326015-ky4y2xjt 8 7 cargo cargo NN cord-326015-ky4y2xjt 8 8 from from IN cord-326015-ky4y2xjt 8 9 cisterna cisterna NNP cord-326015-ky4y2xjt 8 10 to to IN cord-326015-ky4y2xjt 8 11 cisterna cisterna NNP cord-326015-ky4y2xjt 8 12 and and CC cord-326015-ky4y2xjt 8 13 to to TO cord-326015-ky4y2xjt 8 14 recycle recycle VB cord-326015-ky4y2xjt 8 15 components component NNS cord-326015-ky4y2xjt 8 16 needed need VBN cord-326015-ky4y2xjt 8 17 for for IN cord-326015-ky4y2xjt 8 18 further further JJ cord-326015-ky4y2xjt 8 19 rounds round NNS cord-326015-ky4y2xjt 8 20 of of IN cord-326015-ky4y2xjt 8 21 transport transport NN cord-326015-ky4y2xjt 8 22 . . . cord-326015-ky4y2xjt 9 1 Alternatively alternatively RB cord-326015-ky4y2xjt 9 2 , , , cord-326015-ky4y2xjt 9 3 anterograde anterograde JJ cord-326015-ky4y2xjt 9 4 movement movement NN cord-326015-ky4y2xjt 9 5 of of IN cord-326015-ky4y2xjt 9 6 cargo cargo NN cord-326015-ky4y2xjt 9 7 takes take VBZ cord-326015-ky4y2xjt 9 8 place place NN cord-326015-ky4y2xjt 9 9 in in IN cord-326015-ky4y2xjt 9 10 cisternal cisternal JJ cord-326015-ky4y2xjt 9 11 membranes membrane NNS cord-326015-ky4y2xjt 9 12 rather rather RB cord-326015-ky4y2xjt 9 13 than than IN cord-326015-ky4y2xjt 9 14 transport transport NN cord-326015-ky4y2xjt 9 15 vesicles vesicle NNS cord-326015-ky4y2xjt 9 16 . . . cord-326015-ky4y2xjt 10 1 These these DT cord-326015-ky4y2xjt 10 2 membranes membrane NNS cord-326015-ky4y2xjt 10 3 assemble assemble VBP cord-326015-ky4y2xjt 10 4 and and CC cord-326015-ky4y2xjt 10 5 mature mature VBP cord-326015-ky4y2xjt 10 6 in in IN cord-326015-ky4y2xjt 10 7 a a DT cord-326015-ky4y2xjt 10 8 cis cis NNP cord-326015-ky4y2xjt 10 9 to to IN cord-326015-ky4y2xjt 10 10 trans trans NNP cord-326015-ky4y2xjt 10 11 direction direction NN cord-326015-ky4y2xjt 10 12 . . . cord-326015-ky4y2xjt 11 1 In in IN cord-326015-ky4y2xjt 11 2 this this DT cord-326015-ky4y2xjt 11 3 case case NN cord-326015-ky4y2xjt 11 4 , , , cord-326015-ky4y2xjt 11 5 retrograde retrograde JJ cord-326015-ky4y2xjt 11 6 transport transport NN cord-326015-ky4y2xjt 11 7 vesicles vesicle NNS cord-326015-ky4y2xjt 11 8 need need VBP cord-326015-ky4y2xjt 11 9 to to TO cord-326015-ky4y2xjt 11 10 recycle recycle VB cord-326015-ky4y2xjt 11 11 all all DT cord-326015-ky4y2xjt 11 12 components component NNS cord-326015-ky4y2xjt 11 13 of of IN cord-326015-ky4y2xjt 11 14 the the DT cord-326015-ky4y2xjt 11 15 Golgi Golgi NNP cord-326015-ky4y2xjt 11 16 apparatus apparatus NN cord-326015-ky4y2xjt 11 17 and and CC cord-326015-ky4y2xjt 11 18 this this DT cord-326015-ky4y2xjt 11 19 demands demand VBZ cord-326015-ky4y2xjt 11 20 a a DT cord-326015-ky4y2xjt 11 21 highly highly RB cord-326015-ky4y2xjt 11 22 dynamic dynamic JJ cord-326015-ky4y2xjt 11 23 and and CC cord-326015-ky4y2xjt 11 24 efficient efficient JJ cord-326015-ky4y2xjt 11 25 sorting sorting NN cord-326015-ky4y2xjt 11 26 machinery machinery NN cord-326015-ky4y2xjt 11 27 . . . cord-326015-ky4y2xjt 12 1 Here here RB cord-326015-ky4y2xjt 12 2 we -PRON- PRP cord-326015-ky4y2xjt 12 3 will will MD cord-326015-ky4y2xjt 12 4 discuss discuss VB cord-326015-ky4y2xjt 12 5 possible possible JJ cord-326015-ky4y2xjt 12 6 mechanisms mechanism NNS cord-326015-ky4y2xjt 12 7 for for IN cord-326015-ky4y2xjt 12 8 protein protein NN cord-326015-ky4y2xjt 12 9 sorting sorting NN cord-326015-ky4y2xjt 12 10 in in IN cord-326015-ky4y2xjt 12 11 the the DT cord-326015-ky4y2xjt 12 12 context context NN cord-326015-ky4y2xjt 12 13 of of IN cord-326015-ky4y2xjt 12 14 cisternal cisternal JJ cord-326015-ky4y2xjt 12 15 maturation maturation NN cord-326015-ky4y2xjt 12 16 and and CC cord-326015-ky4y2xjt 12 17 propose propose VB cord-326015-ky4y2xjt 12 18 that that IN cord-326015-ky4y2xjt 12 19 a a DT cord-326015-ky4y2xjt 12 20 common common JJ cord-326015-ky4y2xjt 12 21 mechanism mechanism NN cord-326015-ky4y2xjt 12 22 is be VBZ cord-326015-ky4y2xjt 12 23 sufficient sufficient JJ cord-326015-ky4y2xjt 12 24 to to TO cord-326015-ky4y2xjt 12 25 explain explain VB cord-326015-ky4y2xjt 12 26 both both DT cord-326015-ky4y2xjt 12 27 transport transport NN cord-326015-ky4y2xjt 12 28 of of IN cord-326015-ky4y2xjt 12 29 cargo cargo NN cord-326015-ky4y2xjt 12 30 and and CC cord-326015-ky4y2xjt 12 31 sorting sorting NN cord-326015-ky4y2xjt 12 32 of of IN cord-326015-ky4y2xjt 12 33 resident resident JJ cord-326015-ky4y2xjt 12 34 proteins protein NNS cord-326015-ky4y2xjt 12 35 . . . cord-326015-ky4y2xjt 13 1 The the DT cord-326015-ky4y2xjt 13 2 main main JJ cord-326015-ky4y2xjt 13 3 function function NN cord-326015-ky4y2xjt 13 4 of of IN cord-326015-ky4y2xjt 13 5 the the DT cord-326015-ky4y2xjt 13 6 exocytic exocytic JJ cord-326015-ky4y2xjt 13 7 pathway pathway NN cord-326015-ky4y2xjt 13 8 is be VBZ cord-326015-ky4y2xjt 13 9 to to TO cord-326015-ky4y2xjt 13 10 modify modify VB cord-326015-ky4y2xjt 13 11 and and CC cord-326015-ky4y2xjt 13 12 deliver deliver VB cord-326015-ky4y2xjt 13 13 newly newly RB cord-326015-ky4y2xjt 13 14 synthesised synthesise VBN cord-326015-ky4y2xjt 13 15 lipids lipid NNS cord-326015-ky4y2xjt 13 16 and and CC cord-326015-ky4y2xjt 13 17 proteins protein NNS cord-326015-ky4y2xjt 13 18 to to IN cord-326015-ky4y2xjt 13 19 the the DT cord-326015-ky4y2xjt 13 20 cell cell NN cord-326015-ky4y2xjt 13 21 surface surface NN cord-326015-ky4y2xjt 13 22 . . . cord-326015-ky4y2xjt 14 1 This this DT cord-326015-ky4y2xjt 14 2 forward forward JJ cord-326015-ky4y2xjt 14 3 movement movement NN cord-326015-ky4y2xjt 14 4 of of IN cord-326015-ky4y2xjt 14 5 cargo cargo NN cord-326015-ky4y2xjt 14 6 takes take VBZ cord-326015-ky4y2xjt 14 7 place place NN cord-326015-ky4y2xjt 14 8 against against IN cord-326015-ky4y2xjt 14 9 gradients gradient NNS cord-326015-ky4y2xjt 14 10 of of IN cord-326015-ky4y2xjt 14 11 resident resident JJ cord-326015-ky4y2xjt 14 12 proteins protein NNS cord-326015-ky4y2xjt 14 13 which which WDT cord-326015-ky4y2xjt 14 14 occupy occupy VBP cord-326015-ky4y2xjt 14 15 the the DT cord-326015-ky4y2xjt 14 16 pathway pathway NN cord-326015-ky4y2xjt 14 17 . . . cord-326015-ky4y2xjt 15 1 These these DT cord-326015-ky4y2xjt 15 2 are be VBP cord-326015-ky4y2xjt 15 3 enzymes enzyme NNS cord-326015-ky4y2xjt 15 4 which which WDT cord-326015-ky4y2xjt 15 5 catalyse catalyse VBP cord-326015-ky4y2xjt 15 6 a a DT cord-326015-ky4y2xjt 15 7 variety variety NN cord-326015-ky4y2xjt 15 8 of of IN cord-326015-ky4y2xjt 15 9 secondary secondary JJ cord-326015-ky4y2xjt 15 10 modi¢cations modi¢cation NNS cord-326015-ky4y2xjt 15 11 such such JJ cord-326015-ky4y2xjt 15 12 as as IN cord-326015-ky4y2xjt 15 13 processing processing NN cord-326015-ky4y2xjt 15 14 of of IN cord-326015-ky4y2xjt 15 15 N n CD cord-326015-ky4y2xjt 15 16 - - : cord-326015-ky4y2xjt 15 17 and and CC cord-326015-ky4y2xjt 15 18 O o NN cord-326015-ky4y2xjt 15 19 - - HYPH cord-326015-ky4y2xjt 15 20 linked link VBN cord-326015-ky4y2xjt 15 21 oligosaccharides oligosaccharide NNS cord-326015-ky4y2xjt 15 22 , , , cord-326015-ky4y2xjt 15 23 addition addition NN cord-326015-ky4y2xjt 15 24 of of IN cord-326015-ky4y2xjt 15 25 M-6-P m-6-p CD cord-326015-ky4y2xjt 15 26 residues residue NNS cord-326015-ky4y2xjt 15 27 to to IN cord-326015-ky4y2xjt 15 28 lysosomal lysosomal JJ cord-326015-ky4y2xjt 15 29 proteins protein NNS cord-326015-ky4y2xjt 15 30 , , , cord-326015-ky4y2xjt 15 31 sulfation sulfation NN cord-326015-ky4y2xjt 15 32 , , , cord-326015-ky4y2xjt 15 33 phosphorylation phosphorylation NN cord-326015-ky4y2xjt 15 34 or or CC cord-326015-ky4y2xjt 15 35 acetylation acetylation NN cord-326015-ky4y2xjt 15 36 . . . cord-326015-ky4y2xjt 16 1 In in IN cord-326015-ky4y2xjt 16 2 addition addition NN cord-326015-ky4y2xjt 16 3 , , , cord-326015-ky4y2xjt 16 4 proteins protein NNS cord-326015-ky4y2xjt 16 5 that that WDT cord-326015-ky4y2xjt 16 6 confer confer VBP cord-326015-ky4y2xjt 16 7 structure structure NN cord-326015-ky4y2xjt 16 8 and and CC cord-326015-ky4y2xjt 16 9 promote promote VB cord-326015-ky4y2xjt 16 10 motility motility NN cord-326015-ky4y2xjt 16 11 , , , cord-326015-ky4y2xjt 16 12 docking docking NN cord-326015-ky4y2xjt 16 13 and and CC cord-326015-ky4y2xjt 16 14 fusion fusion NN cord-326015-ky4y2xjt 16 15 of of IN cord-326015-ky4y2xjt 16 16 transport transport NN cord-326015-ky4y2xjt 16 17 vesicles vesicle NNS cord-326015-ky4y2xjt 16 18 or or CC cord-326015-ky4y2xjt 16 19 membranes membrane NNS cord-326015-ky4y2xjt 16 20 all all DT cord-326015-ky4y2xjt 16 21 need need VBP cord-326015-ky4y2xjt 16 22 to to TO cord-326015-ky4y2xjt 16 23 be be VB cord-326015-ky4y2xjt 16 24 targeted target VBN cord-326015-ky4y2xjt 16 25 or or CC cord-326015-ky4y2xjt 16 26 recruited recruit VBN cord-326015-ky4y2xjt 16 27 to to IN cord-326015-ky4y2xjt 16 28 their -PRON- PRP$ cord-326015-ky4y2xjt 16 29 appropriate appropriate JJ cord-326015-ky4y2xjt 16 30 location location NN cord-326015-ky4y2xjt 16 31 . . . cord-326015-ky4y2xjt 17 1 In in IN cord-326015-ky4y2xjt 17 2 this this DT cord-326015-ky4y2xjt 17 3 review review NN cord-326015-ky4y2xjt 17 4 , , , cord-326015-ky4y2xjt 17 5 we -PRON- PRP cord-326015-ky4y2xjt 17 6 will will MD cord-326015-ky4y2xjt 17 7 discuss discuss VB cord-326015-ky4y2xjt 17 8 sorting sort VBG cord-326015-ky4y2xjt 17 9 of of IN cord-326015-ky4y2xjt 17 10 resident resident JJ cord-326015-ky4y2xjt 17 11 proteins protein NNS cord-326015-ky4y2xjt 17 12 in in IN cord-326015-ky4y2xjt 17 13 the the DT cord-326015-ky4y2xjt 17 14 Golgi Golgi NNP cord-326015-ky4y2xjt 17 15 complex complex NN cord-326015-ky4y2xjt 17 16 mainly mainly RB cord-326015-ky4y2xjt 17 17 in in IN cord-326015-ky4y2xjt 17 18 the the DT cord-326015-ky4y2xjt 17 19 context context NN cord-326015-ky4y2xjt 17 20 of of IN cord-326015-ky4y2xjt 17 21 cisternal cisternal JJ cord-326015-ky4y2xjt 17 22 maturation maturation NN cord-326015-ky4y2xjt 17 23 [ [ -LRB- cord-326015-ky4y2xjt 17 24 1 1 CD cord-326015-ky4y2xjt 17 25 , , , cord-326015-ky4y2xjt 17 26 2 2 CD cord-326015-ky4y2xjt 17 27 ] ] -RRB- cord-326015-ky4y2xjt 17 28 . . . cord-326015-ky4y2xjt 18 1 This this DT cord-326015-ky4y2xjt 18 2 model model NN cord-326015-ky4y2xjt 18 3 ( ( -LRB- cord-326015-ky4y2xjt 18 4 see see VB cord-326015-ky4y2xjt 18 5 Fig Fig NNP cord-326015-ky4y2xjt 18 6 . . NNP cord-326015-ky4y2xjt 18 7 1 1 CD cord-326015-ky4y2xjt 18 8 ) ) -RRB- cord-326015-ky4y2xjt 18 9 , , , cord-326015-ky4y2xjt 18 10 also also RB cord-326015-ky4y2xjt 18 11 mentioned mention VBN cord-326015-ky4y2xjt 18 12 elsewhere elsewhere RB cord-326015-ky4y2xjt 18 13 in in IN cord-326015-ky4y2xjt 18 14 this this DT cord-326015-ky4y2xjt 18 15 issue issue NN cord-326015-ky4y2xjt 18 16 , , , cord-326015-ky4y2xjt 18 17 provides provide VBZ cord-326015-ky4y2xjt 18 18 an an DT cord-326015-ky4y2xjt 18 19 alternative alternative NN cord-326015-ky4y2xjt 18 20 to to IN cord-326015-ky4y2xjt 18 21 the the DT cord-326015-ky4y2xjt 18 22 current current JJ cord-326015-ky4y2xjt 18 23 textbook textbook NN cord-326015-ky4y2xjt 18 24 model model NN cord-326015-ky4y2xjt 18 25 of of IN cord-326015-ky4y2xjt 18 26 vesicular vesicular JJ cord-326015-ky4y2xjt 18 27 transport transport NN cord-326015-ky4y2xjt 18 28 between between IN cord-326015-ky4y2xjt 18 29 ( ( -LRB- cord-326015-ky4y2xjt 18 30 sub-)compartments sub-)compartment NNS cord-326015-ky4y2xjt 18 31 de¢ned de¢ne VBN cord-326015-ky4y2xjt 18 32 by by IN cord-326015-ky4y2xjt 18 33 function function NN cord-326015-ky4y2xjt 18 34 and and CC cord-326015-ky4y2xjt 18 35 composition composition NN cord-326015-ky4y2xjt 18 36 . . . cord-326015-ky4y2xjt 19 1 Several several JJ cord-326015-ky4y2xjt 19 2 excellent excellent JJ cord-326015-ky4y2xjt 19 3 reviews review NNS cord-326015-ky4y2xjt 19 4 discussing discuss VBG cord-326015-ky4y2xjt 19 5 vesicular vesicular JJ cord-326015-ky4y2xjt 19 6 transport transport NN cord-326015-ky4y2xjt 19 7 and and CC cord-326015-ky4y2xjt 19 8 protein protein NN cord-326015-ky4y2xjt 19 9 sorting sorting NN cord-326015-ky4y2xjt 19 10 have have VBP cord-326015-ky4y2xjt 19 11 been be VBN cord-326015-ky4y2xjt 19 12 published publish VBN cord-326015-ky4y2xjt 19 13 over over IN cord-326015-ky4y2xjt 19 14 the the DT cord-326015-ky4y2xjt 19 15 years year NNS cord-326015-ky4y2xjt 19 16 ( ( -LRB- cord-326015-ky4y2xjt 19 17 e.g. e.g. NN cord-326015-ky4y2xjt 19 18 [ [ -LRB- cord-326015-ky4y2xjt 19 19 3 3 CD cord-326015-ky4y2xjt 19 20 , , , cord-326015-ky4y2xjt 19 21 4 4 CD cord-326015-ky4y2xjt 19 22 ] ] -RRB- cord-326015-ky4y2xjt 19 23 ) ) -RRB- cord-326015-ky4y2xjt 19 24 and and CC cord-326015-ky4y2xjt 19 25 though though IN cord-326015-ky4y2xjt 19 26 much much JJ cord-326015-ky4y2xjt 19 27 attention attention NN cord-326015-ky4y2xjt 19 28 has have VBZ cord-326015-ky4y2xjt 19 29 been be VBN cord-326015-ky4y2xjt 19 30 given give VBN cord-326015-ky4y2xjt 19 31 to to IN cord-326015-ky4y2xjt 19 32 this this DT cord-326015-ky4y2xjt 19 33 model model NN cord-326015-ky4y2xjt 19 34 , , , cord-326015-ky4y2xjt 19 35 the the DT cord-326015-ky4y2xjt 19 36 cisternal cisternal JJ cord-326015-ky4y2xjt 19 37 maturation maturation NN cord-326015-ky4y2xjt 19 38 model model NN cord-326015-ky4y2xjt 19 39 has have VBZ cord-326015-ky4y2xjt 19 40 remained remain VBN cord-326015-ky4y2xjt 19 41 a a DT cord-326015-ky4y2xjt 19 42 good good JJ cord-326015-ky4y2xjt 19 43 alternative alternative NN cord-326015-ky4y2xjt 19 44 reconciling reconcile VBG cord-326015-ky4y2xjt 19 45 many many JJ cord-326015-ky4y2xjt 19 46 observations observation NNS cord-326015-ky4y2xjt 19 47 incompatible incompatible JJ cord-326015-ky4y2xjt 19 48 with with IN cord-326015-ky4y2xjt 19 49 the the DT cord-326015-ky4y2xjt 19 50 vesicular vesicular JJ cord-326015-ky4y2xjt 19 51 transport transport NN cord-326015-ky4y2xjt 19 52 model model NN cord-326015-ky4y2xjt 19 53 . . . cord-326015-ky4y2xjt 20 1 For for IN cord-326015-ky4y2xjt 20 2 example example NN cord-326015-ky4y2xjt 20 3 , , , cord-326015-ky4y2xjt 20 4 macromolecules macromolecule NNS cord-326015-ky4y2xjt 20 5 too too RB cord-326015-ky4y2xjt 20 6 large large JJ cord-326015-ky4y2xjt 20 7 to to TO cord-326015-ky4y2xjt 20 8 enter enter VB cord-326015-ky4y2xjt 20 9 transport transport NN cord-326015-ky4y2xjt 20 10 vesicles vesicle NNS cord-326015-ky4y2xjt 20 11 still still RB cord-326015-ky4y2xjt 20 12 move move VBP cord-326015-ky4y2xjt 20 13 through through IN cord-326015-ky4y2xjt 20 14 the the DT cord-326015-ky4y2xjt 20 15 secretory secretory JJ cord-326015-ky4y2xjt 20 16 pathway pathway NN cord-326015-ky4y2xjt 20 17 and and CC cord-326015-ky4y2xjt 20 18 are be VBP cord-326015-ky4y2xjt 20 19 readily readily RB cord-326015-ky4y2xjt 20 20 found find VBN cord-326015-ky4y2xjt 20 21 in in IN cord-326015-ky4y2xjt 20 22 cisternal cisternal JJ cord-326015-ky4y2xjt 20 23 membranes membrane NNS cord-326015-ky4y2xjt 20 24 of of IN cord-326015-ky4y2xjt 20 25 Golgi Golgi NNP cord-326015-ky4y2xjt 20 26 stacks stack NNS cord-326015-ky4y2xjt 20 27 . . . cord-326015-ky4y2xjt 21 1 This this DT cord-326015-ky4y2xjt 21 2 is be VBZ cord-326015-ky4y2xjt 21 3 most most RBS cord-326015-ky4y2xjt 21 4 obvious obvious JJ cord-326015-ky4y2xjt 21 5 in in IN cord-326015-ky4y2xjt 21 6 some some DT cord-326015-ky4y2xjt 21 7 algae algae NN cord-326015-ky4y2xjt 21 8 where where WRB cord-326015-ky4y2xjt 21 9 a a DT cord-326015-ky4y2xjt 21 10 gradient gradient NN cord-326015-ky4y2xjt 21 11 of of IN cord-326015-ky4y2xjt 21 12 macromolecular macromolecular JJ cord-326015-ky4y2xjt 21 13 ( ( -LRB- cord-326015-ky4y2xjt 21 14 scale scale NN cord-326015-ky4y2xjt 21 15 ) ) -RRB- cord-326015-ky4y2xjt 21 16 assembly assembly NN cord-326015-ky4y2xjt 21 17 is be VBZ cord-326015-ky4y2xjt 21 18 revealed reveal VBN cord-326015-ky4y2xjt 21 19 in in IN cord-326015-ky4y2xjt 21 20 a a DT cord-326015-ky4y2xjt 21 21 cis cis NNP cord-326015-ky4y2xjt 21 22 to to IN cord-326015-ky4y2xjt 21 23 trans trans NNP cord-326015-ky4y2xjt 21 24 direction direction NNP cord-326015-ky4y2xjt 21 25 strongly strongly RB cord-326015-ky4y2xjt 21 26 suggestive suggestive JJ cord-326015-ky4y2xjt 21 27 of of IN cord-326015-ky4y2xjt 21 28 a a DT cord-326015-ky4y2xjt 21 29 maturation maturation NN cord-326015-ky4y2xjt 21 30 process process NN cord-326015-ky4y2xjt 21 31 ( ( -LRB- cord-326015-ky4y2xjt 21 32 reviewed review VBN cord-326015-ky4y2xjt 21 33 by by IN cord-326015-ky4y2xjt 21 34 [ [ -LRB- cord-326015-ky4y2xjt 21 35 5 5 CD cord-326015-ky4y2xjt 21 36 ] ] -RRB- cord-326015-ky4y2xjt 21 37 ) ) -RRB- cord-326015-ky4y2xjt 21 38 . . . cord-326015-ky4y2xjt 22 1 Morphologically Morphologically NNP cord-326015-ky4y2xjt 22 2 , , , cord-326015-ky4y2xjt 22 3 the the DT cord-326015-ky4y2xjt 22 4 Golgi Golgi NNP cord-326015-ky4y2xjt 22 5 apparatus apparatus NN cord-326015-ky4y2xjt 22 6 also also RB cord-326015-ky4y2xjt 22 7 exhibits exhibit VBZ cord-326015-ky4y2xjt 22 8 the the DT cord-326015-ky4y2xjt 22 9 structural structural JJ cord-326015-ky4y2xjt 22 10 characteristics characteristic NNS cord-326015-ky4y2xjt 22 11 of of IN cord-326015-ky4y2xjt 22 12 an an DT cord-326015-ky4y2xjt 22 13 organelle organelle NN cord-326015-ky4y2xjt 22 14 in in IN cord-326015-ky4y2xjt 22 15 transit transit NN cord-326015-ky4y2xjt 22 16 , , , cord-326015-ky4y2xjt 22 17 that that RB cord-326015-ky4y2xjt 22 18 is is RB cord-326015-ky4y2xjt 22 19 , , , cord-326015-ky4y2xjt 22 20 one one CD cord-326015-ky4y2xjt 22 21 which which WDT cord-326015-ky4y2xjt 22 22 is be VBZ cord-326015-ky4y2xjt 22 23 assembled assemble VBN cord-326015-ky4y2xjt 22 24 at at IN cord-326015-ky4y2xjt 22 25 the the DT cord-326015-ky4y2xjt 22 26 cis cis NNP cord-326015-ky4y2xjt 22 27 side side NN cord-326015-ky4y2xjt 22 28 and and CC cord-326015-ky4y2xjt 22 29 taken take VBN cord-326015-ky4y2xjt 22 30 apart apart RB cord-326015-ky4y2xjt 22 31 at at IN cord-326015-ky4y2xjt 22 32 the the DT cord-326015-ky4y2xjt 22 33 trans trans NNP cord-326015-ky4y2xjt 22 34 side side NN cord-326015-ky4y2xjt 22 35 ( ( -LRB- cord-326015-ky4y2xjt 22 36 for for IN cord-326015-ky4y2xjt 22 37 review review NN cord-326015-ky4y2xjt 22 38 , , , cord-326015-ky4y2xjt 22 39 see see VB cord-326015-ky4y2xjt 22 40 [ [ -LRB- cord-326015-ky4y2xjt 22 41 6 6 CD cord-326015-ky4y2xjt 22 42 ] ] -RRB- cord-326015-ky4y2xjt 22 43 ) ) -RRB- cord-326015-ky4y2xjt 22 44 . . . cord-326015-ky4y2xjt 23 1 One one CD cord-326015-ky4y2xjt 23 2 of of IN cord-326015-ky4y2xjt 23 3 the the DT cord-326015-ky4y2xjt 23 4 attractive attractive JJ cord-326015-ky4y2xjt 23 5 features feature NNS cord-326015-ky4y2xjt 23 6 of of IN cord-326015-ky4y2xjt 23 7 the the DT cord-326015-ky4y2xjt 23 8 cisternal cisternal JJ cord-326015-ky4y2xjt 23 9 maturation maturation NN cord-326015-ky4y2xjt 23 10 model model NN cord-326015-ky4y2xjt 23 11 is be VBZ cord-326015-ky4y2xjt 23 12 that that IN cord-326015-ky4y2xjt 23 13 there there EX cord-326015-ky4y2xjt 23 14 are be VBP cord-326015-ky4y2xjt 23 15 no no DT cord-326015-ky4y2xjt 23 16 pre pre JJ cord-326015-ky4y2xjt 23 17 - - JJ cord-326015-ky4y2xjt 23 18 existing existing JJ cord-326015-ky4y2xjt 23 19 compartments compartment NNS cord-326015-ky4y2xjt 23 20 apart apart RB cord-326015-ky4y2xjt 23 21 from from IN cord-326015-ky4y2xjt 23 22 the the DT cord-326015-ky4y2xjt 23 23 ER ER NNP cord-326015-ky4y2xjt 23 24 . . . cord-326015-ky4y2xjt 24 1 This this DT cord-326015-ky4y2xjt 24 2 is be VBZ cord-326015-ky4y2xjt 24 3 in in IN cord-326015-ky4y2xjt 24 4 contrast contrast NN cord-326015-ky4y2xjt 24 5 to to IN cord-326015-ky4y2xjt 24 6 the the DT cord-326015-ky4y2xjt 24 7 vesicular vesicular JJ cord-326015-ky4y2xjt 24 8 transport transport NN cord-326015-ky4y2xjt 24 9 model model NN cord-326015-ky4y2xjt 24 10 where where WRB cord-326015-ky4y2xjt 24 11 the the DT cord-326015-ky4y2xjt 24 12 pathway pathway NN cord-326015-ky4y2xjt 24 13 is be VBZ cord-326015-ky4y2xjt 24 14 divided divide VBN cord-326015-ky4y2xjt 24 15 into into IN cord-326015-ky4y2xjt 24 16 several several JJ cord-326015-ky4y2xjt 24 17 ( ( -LRB- cord-326015-ky4y2xjt 24 18 sub-)compartments sub-)compartment NNS cord-326015-ky4y2xjt 24 19 ; ; : cord-326015-ky4y2xjt 24 20 the the DT cord-326015-ky4y2xjt 24 21 ER ER NNP cord-326015-ky4y2xjt 24 22 , , , cord-326015-ky4y2xjt 24 23 the the DT cord-326015-ky4y2xjt 24 24 ER ER NNP cord-326015-ky4y2xjt 24 25 to to IN cord-326015-ky4y2xjt 24 26 Golgi Golgi NNP cord-326015-ky4y2xjt 24 27 intermediate intermediate JJ cord-326015-ky4y2xjt 24 28 compartment compartment NN cord-326015-ky4y2xjt 24 29 ( ( -LRB- cord-326015-ky4y2xjt 24 30 ERGIC ERGIC NNP cord-326015-ky4y2xjt 24 31 ) ) -RRB- cord-326015-ky4y2xjt 24 32 , , , cord-326015-ky4y2xjt 24 33 cis cis NNP cord-326015-ky4y2xjt 24 34 Golgi Golgi NNP cord-326015-ky4y2xjt 24 35 network network NN cord-326015-ky4y2xjt 24 36 ( ( -LRB- cord-326015-ky4y2xjt 24 37 CGN CGN NNP cord-326015-ky4y2xjt 24 38 ) ) -RRB- cord-326015-ky4y2xjt 24 39 , , , cord-326015-ky4y2xjt 24 40 cis cis NNP cord-326015-ky4y2xjt 24 41 , , , cord-326015-ky4y2xjt 24 42 medial medial NNP cord-326015-ky4y2xjt 24 43 , , , cord-326015-ky4y2xjt 24 44 trans trans NNP cord-326015-ky4y2xjt 24 45 cisternae cisternae NNP cord-326015-ky4y2xjt 24 46 and and CC cord-326015-ky4y2xjt 24 47 the the DT cord-326015-ky4y2xjt 24 48 trans trans NNP cord-326015-ky4y2xjt 24 49 Golgi Golgi NNP cord-326015-ky4y2xjt 24 50 network network NN cord-326015-ky4y2xjt 24 51 ( ( -LRB- cord-326015-ky4y2xjt 24 52 TGN TGN NNP cord-326015-ky4y2xjt 24 53 ) ) -RRB- cord-326015-ky4y2xjt 24 54 . . . cord-326015-ky4y2xjt 25 1 These these DT cord-326015-ky4y2xjt 25 2 are be VBP cord-326015-ky4y2xjt 25 3 read- read- JJ cord-326015-ky4y2xjt 25 4 Fig Fig NNP cord-326015-ky4y2xjt 25 5 . . . cord-326015-ky4y2xjt 26 1 1 1 LS cord-326015-ky4y2xjt 26 2 . . . cord-326015-ky4y2xjt 27 1 How how WRB cord-326015-ky4y2xjt 27 2 cisternal cisternal JJ cord-326015-ky4y2xjt 27 3 maturation maturation NN cord-326015-ky4y2xjt 27 4 would would MD cord-326015-ky4y2xjt 27 5 work work VB cord-326015-ky4y2xjt 27 6 . . . cord-326015-ky4y2xjt 28 1 Importantly importantly RB cord-326015-ky4y2xjt 28 2 , , , cord-326015-ky4y2xjt 28 3 this this DT cord-326015-ky4y2xjt 28 4 drawing drawing NN cord-326015-ky4y2xjt 28 5 depicts depict VBZ cord-326015-ky4y2xjt 28 6 not not RB cord-326015-ky4y2xjt 28 7 spatial spatial JJ cord-326015-ky4y2xjt 28 8 but but CC cord-326015-ky4y2xjt 28 9 time time NN cord-326015-ky4y2xjt 28 10 resolution resolution NN cord-326015-ky4y2xjt 28 11 . . . cord-326015-ky4y2xjt 29 1 A a DT cord-326015-ky4y2xjt 29 2 given give VBN cord-326015-ky4y2xjt 29 3 population population NN cord-326015-ky4y2xjt 29 4 of of IN cord-326015-ky4y2xjt 29 5 cargo cargo NN cord-326015-ky4y2xjt 29 6 molecules molecule NNS cord-326015-ky4y2xjt 29 7 moves move VBZ cord-326015-ky4y2xjt 29 8 over over IN cord-326015-ky4y2xjt 29 9 time time NN cord-326015-ky4y2xjt 30 1 t0^t5 t0^t5 CD cord-326015-ky4y2xjt 31 1 through through IN cord-326015-ky4y2xjt 31 2 the the DT cord-326015-ky4y2xjt 31 3 secretory secretory JJ cord-326015-ky4y2xjt 31 4 pathway pathway NN cord-326015-ky4y2xjt 31 5 . . . cord-326015-ky4y2xjt 32 1 t0 t0 NNP cord-326015-ky4y2xjt 32 2 : : : cord-326015-ky4y2xjt 33 1 Cargo cargo NN cord-326015-ky4y2xjt 33 2 is be VBZ cord-326015-ky4y2xjt 33 3 selected select VBN cord-326015-ky4y2xjt 33 4 and and CC cord-326015-ky4y2xjt 33 5 concentrated concentrate VBN cord-326015-ky4y2xjt 33 6 at at IN cord-326015-ky4y2xjt 33 7 ER ER NNP cord-326015-ky4y2xjt 33 8 exit exit NN cord-326015-ky4y2xjt 33 9 sites site NNS cord-326015-ky4y2xjt 33 10 with with IN cord-326015-ky4y2xjt 33 11 the the DT cord-326015-ky4y2xjt 33 12 help help NN cord-326015-ky4y2xjt 33 13 of of IN cord-326015-ky4y2xjt 33 14 COP cop NN cord-326015-ky4y2xjt 33 15 II II NNP cord-326015-ky4y2xjt 33 16 components component NNS cord-326015-ky4y2xjt 33 17 . . . cord-326015-ky4y2xjt 34 1 t1 t1 NN cord-326015-ky4y2xjt 34 2 : : : cord-326015-ky4y2xjt 35 1 COP cop NN cord-326015-ky4y2xjt 35 2 II II NNP cord-326015-ky4y2xjt 35 3 vesicles vesicle NNS cord-326015-ky4y2xjt 35 4 shed shed VBP cord-326015-ky4y2xjt 35 5 their -PRON- PRP$ cord-326015-ky4y2xjt 35 6 coat coat NN cord-326015-ky4y2xjt 35 7 and and CC cord-326015-ky4y2xjt 35 8 fuse fuse VB cord-326015-ky4y2xjt 35 9 with with IN cord-326015-ky4y2xjt 35 10 retrograde retrograde JJ cord-326015-ky4y2xjt 35 11 COP cop NN cord-326015-ky4y2xjt 36 1 I -PRON- PRP cord-326015-ky4y2xjt 36 2 vesicles vesicle VBZ cord-326015-ky4y2xjt 36 3 carrying carry VBG cord-326015-ky4y2xjt 36 4 cis cis NNP cord-326015-ky4y2xjt 36 5 Golgi Golgi NNP cord-326015-ky4y2xjt 36 6 proteins protein NNS cord-326015-ky4y2xjt 36 7 , , , cord-326015-ky4y2xjt 36 8 forming form VBG cord-326015-ky4y2xjt 36 9 the the DT cord-326015-ky4y2xjt 36 10 ¢rst ¢rst NNP cord-326015-ky4y2xjt 36 11 cisterna cisterna NNP cord-326015-ky4y2xjt 36 12 of of IN cord-326015-ky4y2xjt 36 13 the the DT cord-326015-ky4y2xjt 36 14 Golgi Golgi NNP cord-326015-ky4y2xjt 36 15 apparatus apparatus NN cord-326015-ky4y2xjt 36 16 . . . cord-326015-ky4y2xjt 37 1 t2 t2 NNP cord-326015-ky4y2xjt 37 2 : : : cord-326015-ky4y2xjt 38 1 Cargo cargo NN cord-326015-ky4y2xjt 38 2 is be VBZ cord-326015-ky4y2xjt 38 3 modi¢ed modi¢ed `` cord-326015-ky4y2xjt 38 4 by by IN cord-326015-ky4y2xjt 38 5 cis cis NNP cord-326015-ky4y2xjt 38 6 Golgi Golgi NNP cord-326015-ky4y2xjt 38 7 proteins protein NNS cord-326015-ky4y2xjt 38 8 , , , cord-326015-ky4y2xjt 38 9 and and CC cord-326015-ky4y2xjt 38 10 these these DT cord-326015-ky4y2xjt 38 11 enzymes enzyme NNS cord-326015-ky4y2xjt 38 12 are be VBP cord-326015-ky4y2xjt 38 13 recycling recycle VBG cord-326015-ky4y2xjt 38 14 to to TO cord-326015-ky4y2xjt 38 15 fuse fuse VB cord-326015-ky4y2xjt 38 16 with with IN cord-326015-ky4y2xjt 38 17 COP cop NN cord-326015-ky4y2xjt 38 18 II II NNP cord-326015-ky4y2xjt 38 19 vesicles vesicle NNS cord-326015-ky4y2xjt 38 20 ; ; : cord-326015-ky4y2xjt 38 21 at at IN cord-326015-ky4y2xjt 38 22 the the DT cord-326015-ky4y2xjt 38 23 same same JJ cord-326015-ky4y2xjt 38 24 time time NN cord-326015-ky4y2xjt 38 25 , , , cord-326015-ky4y2xjt 38 26 retrograde retrograde JJ cord-326015-ky4y2xjt 38 27 vesicles vesicle NNS cord-326015-ky4y2xjt 38 28 containing contain VBG cord-326015-ky4y2xjt 38 29 medial medial JJ cord-326015-ky4y2xjt 38 30 Golgi Golgi NNP cord-326015-ky4y2xjt 38 31 enzymes enzyme NNS cord-326015-ky4y2xjt 38 32 start start VBP cord-326015-ky4y2xjt 38 33 to to TO cord-326015-ky4y2xjt 38 34 join join VB cord-326015-ky4y2xjt 38 35 the the DT cord-326015-ky4y2xjt 38 36 cargo cargo NN cord-326015-ky4y2xjt 38 37 containing contain VBG cord-326015-ky4y2xjt 38 38 cisterna cisterna NNP cord-326015-ky4y2xjt 38 39 . . . cord-326015-ky4y2xjt 39 1 t3 t3 NNP cord-326015-ky4y2xjt 39 2 : : : cord-326015-ky4y2xjt 40 1 Cargo cargo NN cord-326015-ky4y2xjt 40 2 is be VBZ cord-326015-ky4y2xjt 40 3 modi¢ed modi¢ed `` cord-326015-ky4y2xjt 40 4 by by IN cord-326015-ky4y2xjt 40 5 medial medial JJ cord-326015-ky4y2xjt 40 6 Golgi Golgi NNP cord-326015-ky4y2xjt 40 7 proteins protein NNS cord-326015-ky4y2xjt 40 8 , , , cord-326015-ky4y2xjt 40 9 and and CC cord-326015-ky4y2xjt 40 10 these these DT cord-326015-ky4y2xjt 40 11 enzymes enzyme NNS cord-326015-ky4y2xjt 40 12 are be VBP cord-326015-ky4y2xjt 40 13 recycling recycle VBG cord-326015-ky4y2xjt 40 14 to to TO cord-326015-ky4y2xjt 40 15 fuse fuse VB cord-326015-ky4y2xjt 40 16 with with IN cord-326015-ky4y2xjt 40 17 cis cis NNP cord-326015-ky4y2xjt 40 18 Golgi Golgi NNP cord-326015-ky4y2xjt 40 19 cisternae cisternae NNP cord-326015-ky4y2xjt 40 20 ; ; : cord-326015-ky4y2xjt 40 21 at at IN cord-326015-ky4y2xjt 40 22 the the DT cord-326015-ky4y2xjt 40 23 same same JJ cord-326015-ky4y2xjt 40 24 time time NN cord-326015-ky4y2xjt 40 25 , , , cord-326015-ky4y2xjt 40 26 retrograde retrograde JJ cord-326015-ky4y2xjt 40 27 vesicles vesicle NNS cord-326015-ky4y2xjt 40 28 containing contain VBG cord-326015-ky4y2xjt 40 29 trans trans NNP cord-326015-ky4y2xjt 40 30 Golgi Golgi NNP cord-326015-ky4y2xjt 40 31 enzymes enzyme NNS cord-326015-ky4y2xjt 40 32 start start VBP cord-326015-ky4y2xjt 40 33 to to TO cord-326015-ky4y2xjt 40 34 join join VB cord-326015-ky4y2xjt 40 35 the the DT cord-326015-ky4y2xjt 40 36 cargo cargo NN cord-326015-ky4y2xjt 40 37 containing contain VBG cord-326015-ky4y2xjt 40 38 cisterna cisterna NNP cord-326015-ky4y2xjt 40 39 . . . cord-326015-ky4y2xjt 41 1 t4 t4 NNP cord-326015-ky4y2xjt 41 2 : : : cord-326015-ky4y2xjt 42 1 Cargo cargo NN cord-326015-ky4y2xjt 42 2 is be VBZ cord-326015-ky4y2xjt 42 3 modi¢ed modi¢ed `` cord-326015-ky4y2xjt 42 4 by by IN cord-326015-ky4y2xjt 42 5 trans trans NNP cord-326015-ky4y2xjt 42 6 Golgi Golgi NNP cord-326015-ky4y2xjt 42 7 enzymes enzyme NNS cord-326015-ky4y2xjt 42 8 , , , cord-326015-ky4y2xjt 42 9 and and CC cord-326015-ky4y2xjt 42 10 these these DT cord-326015-ky4y2xjt 42 11 enzymes enzyme NNS cord-326015-ky4y2xjt 42 12 are be VBP cord-326015-ky4y2xjt 42 13 recycling recycle VBG cord-326015-ky4y2xjt 42 14 to to TO cord-326015-ky4y2xjt 42 15 fuse fuse VB cord-326015-ky4y2xjt 42 16 with with IN cord-326015-ky4y2xjt 42 17 medial medial JJ cord-326015-ky4y2xjt 42 18 cisternae cisternae NN cord-326015-ky4y2xjt 42 19 ; ; : cord-326015-ky4y2xjt 42 20 sorting sort VBG cord-326015-ky4y2xjt 42 21 and and CC cord-326015-ky4y2xjt 42 22 budding budding NN cord-326015-ky4y2xjt 42 23 of of IN cord-326015-ky4y2xjt 42 24 vesicles vesicle NNS cord-326015-ky4y2xjt 42 25 result result VBP cord-326015-ky4y2xjt 42 26 ultimately ultimately RB cord-326015-ky4y2xjt 42 27 in in IN cord-326015-ky4y2xjt 42 28 the the DT cord-326015-ky4y2xjt 42 29 consumption consumption NN cord-326015-ky4y2xjt 42 30 of of IN cord-326015-ky4y2xjt 42 31 the the DT cord-326015-ky4y2xjt 42 32 trans trans NNP cord-326015-ky4y2xjt 42 33 cisterna cisterna NNP cord-326015-ky4y2xjt 42 34 . . . cord-326015-ky4y2xjt 43 1 t5 t5 NNP cord-326015-ky4y2xjt 43 2 : : : cord-326015-ky4y2xjt 44 1 Vesicles vesicle NNS cord-326015-ky4y2xjt 44 2 move move VBP cord-326015-ky4y2xjt 44 3 to to IN cord-326015-ky4y2xjt 44 4 lysosomes lysosome NNS cord-326015-ky4y2xjt 44 5 , , , cord-326015-ky4y2xjt 44 6 secretory secretory NN cord-326015-ky4y2xjt 44 7 granules granule NNS cord-326015-ky4y2xjt 44 8 or or CC cord-326015-ky4y2xjt 44 9 the the DT cord-326015-ky4y2xjt 44 10 plasma plasma NN cord-326015-ky4y2xjt 44 11 membrane membrane NN cord-326015-ky4y2xjt 44 12 . . . cord-326015-ky4y2xjt 45 1 The the DT cord-326015-ky4y2xjt 45 2 grey grey JJ cord-326015-ky4y2xjt 45 3 bars bar NNS cord-326015-ky4y2xjt 45 4 at at IN cord-326015-ky4y2xjt 45 5 the the DT cord-326015-ky4y2xjt 45 6 cytosolic cytosolic JJ cord-326015-ky4y2xjt 45 7 face face NN cord-326015-ky4y2xjt 45 8 of of IN cord-326015-ky4y2xjt 45 9 the the DT cord-326015-ky4y2xjt 45 10 individual individual JJ cord-326015-ky4y2xjt 45 11 cisternae cisternae NN cord-326015-ky4y2xjt 45 12 correspond correspond VB cord-326015-ky4y2xjt 45 13 to to IN cord-326015-ky4y2xjt 45 14 the the DT cord-326015-ky4y2xjt 45 15 intracisternal intracisternal JJ cord-326015-ky4y2xjt 45 16 matrix matrix NN cord-326015-ky4y2xjt 45 17 . . . cord-326015-ky4y2xjt 46 1 If if IN cord-326015-ky4y2xjt 46 2 cargo cargo NN cord-326015-ky4y2xjt 46 3 molecules molecule NNS cord-326015-ky4y2xjt 46 4 have have VBP cord-326015-ky4y2xjt 46 5 a a DT cord-326015-ky4y2xjt 46 6 certain certain JJ cord-326015-ky4y2xjt 46 7 a¤nity a¤nity NN cord-326015-ky4y2xjt 46 8 for for IN cord-326015-ky4y2xjt 46 9 retrograde retrograde JJ cord-326015-ky4y2xjt 46 10 vesicles vesicle NNS cord-326015-ky4y2xjt 46 11 , , , cord-326015-ky4y2xjt 46 12 they -PRON- PRP cord-326015-ky4y2xjt 46 13 would would MD cord-326015-ky4y2xjt 46 14 undergo undergo VB cord-326015-ky4y2xjt 46 15 more more JJR cord-326015-ky4y2xjt 46 16 than than IN cord-326015-ky4y2xjt 46 17 one one CD cord-326015-ky4y2xjt 46 18 round round NN cord-326015-ky4y2xjt 46 19 of of IN cord-326015-ky4y2xjt 46 20 maturation maturation NN cord-326015-ky4y2xjt 46 21 thus thus RB cord-326015-ky4y2xjt 46 22 explaining explain VBG cord-326015-ky4y2xjt 46 23 di¡erent di¡erent NNP cord-326015-ky4y2xjt 46 24 kinetics kinetic NNS cord-326015-ky4y2xjt 46 25 for for IN cord-326015-ky4y2xjt 46 26 transport transport NN cord-326015-ky4y2xjt 46 27 from from IN cord-326015-ky4y2xjt 46 28 ER ER NNP cord-326015-ky4y2xjt 46 29 to to IN cord-326015-ky4y2xjt 46 30 plasma plasma NN cord-326015-ky4y2xjt 46 31 membrane membrane NN cord-326015-ky4y2xjt 46 32 . . . cord-326015-ky4y2xjt 47 1 An an DT cord-326015-ky4y2xjt 47 2 essential essential JJ cord-326015-ky4y2xjt 47 3 feature feature NN cord-326015-ky4y2xjt 47 4 of of IN cord-326015-ky4y2xjt 47 5 this this DT cord-326015-ky4y2xjt 47 6 maturation maturation NN cord-326015-ky4y2xjt 47 7 model model NN cord-326015-ky4y2xjt 47 8 is be VBZ cord-326015-ky4y2xjt 47 9 the the DT cord-326015-ky4y2xjt 47 10 prediction prediction NN cord-326015-ky4y2xjt 47 11 that that IN cord-326015-ky4y2xjt 47 12 Golgi Golgi NNP cord-326015-ky4y2xjt 47 13 resident resident NN cord-326015-ky4y2xjt 47 14 proteins protein NNS cord-326015-ky4y2xjt 47 15 are be VBP cord-326015-ky4y2xjt 47 16 more more RBR cord-326015-ky4y2xjt 47 17 concentrated concentrated JJ cord-326015-ky4y2xjt 47 18 in in IN cord-326015-ky4y2xjt 47 19 retrograde retrograde JJ cord-326015-ky4y2xjt 47 20 vesicles vesicle NNS cord-326015-ky4y2xjt 47 21 than than IN cord-326015-ky4y2xjt 47 22 they -PRON- PRP cord-326015-ky4y2xjt 47 23 are be VBP cord-326015-ky4y2xjt 47 24 in in IN cord-326015-ky4y2xjt 47 25 the the DT cord-326015-ky4y2xjt 47 26 cisternae cisternae NN cord-326015-ky4y2xjt 47 27 of of IN cord-326015-ky4y2xjt 47 28 the the DT cord-326015-ky4y2xjt 47 29 Golgi Golgi NNP cord-326015-ky4y2xjt 47 30 apparatus apparatus NN cord-326015-ky4y2xjt 47 31 . . . cord-326015-ky4y2xjt 48 1 Furthermore furthermore RB cord-326015-ky4y2xjt 48 2 , , , cord-326015-ky4y2xjt 48 3 since since IN cord-326015-ky4y2xjt 48 4 new new JJ cord-326015-ky4y2xjt 48 5 cisternae cisternae NNP cord-326015-ky4y2xjt 48 6 are be VBP cord-326015-ky4y2xjt 48 7 only only RB cord-326015-ky4y2xjt 48 8 assembled assemble VBN cord-326015-ky4y2xjt 48 9 at at IN cord-326015-ky4y2xjt 48 10 the the DT cord-326015-ky4y2xjt 48 11 ER ER NNP cord-326015-ky4y2xjt 48 12 - - HYPH cord-326015-ky4y2xjt 48 13 Golgi Golgi NNP cord-326015-ky4y2xjt 48 14 intermediate intermediate JJ cord-326015-ky4y2xjt 48 15 compartment compartment NN cord-326015-ky4y2xjt 48 16 , , , cord-326015-ky4y2xjt 48 17 every every DT cord-326015-ky4y2xjt 48 18 cisterna cisterna NNP cord-326015-ky4y2xjt 48 19 has have VBZ cord-326015-ky4y2xjt 48 20 to to TO cord-326015-ky4y2xjt 48 21 move move VB cord-326015-ky4y2xjt 48 22 forward forward RB cord-326015-ky4y2xjt 48 23 to to TO cord-326015-ky4y2xjt 48 24 provide provide VB cord-326015-ky4y2xjt 48 25 space space NN cord-326015-ky4y2xjt 48 26 for for IN cord-326015-ky4y2xjt 48 27 newly newly RB cord-326015-ky4y2xjt 48 28 forming form VBG cord-326015-ky4y2xjt 48 29 cisternae cisternae NN cord-326015-ky4y2xjt 48 30 . . . cord-326015-ky4y2xjt 49 1 ily ily NNP cord-326015-ky4y2xjt 49 2 discernible discernible JJ cord-326015-ky4y2xjt 49 3 morphologically morphologically RB cord-326015-ky4y2xjt 49 4 and and CC cord-326015-ky4y2xjt 49 5 therefore therefore RB cord-326015-ky4y2xjt 49 6 serve serve VBP cord-326015-ky4y2xjt 49 7 as as IN cord-326015-ky4y2xjt 49 8 useful useful JJ cord-326015-ky4y2xjt 49 9 names name NNS cord-326015-ky4y2xjt 49 10 . . . cord-326015-ky4y2xjt 50 1 However however RB cord-326015-ky4y2xjt 50 2 , , , cord-326015-ky4y2xjt 50 3 in in IN cord-326015-ky4y2xjt 50 4 the the DT cord-326015-ky4y2xjt 50 5 cisternal cisternal JJ cord-326015-ky4y2xjt 50 6 maturation maturation NN cord-326015-ky4y2xjt 50 7 model model NN cord-326015-ky4y2xjt 50 8 , , , cord-326015-ky4y2xjt 50 9 they -PRON- PRP cord-326015-ky4y2xjt 50 10 re£ect re£ect VBP cord-326015-ky4y2xjt 50 11 early early RB cord-326015-ky4y2xjt 50 12 to to IN cord-326015-ky4y2xjt 50 13 late late JJ cord-326015-ky4y2xjt 50 14 maturation maturation NN cord-326015-ky4y2xjt 50 15 stages stage NNS cord-326015-ky4y2xjt 50 16 of of IN cord-326015-ky4y2xjt 50 17 the the DT cord-326015-ky4y2xjt 50 18 cisternal cisternal JJ cord-326015-ky4y2xjt 50 19 cargo cargo NN cord-326015-ky4y2xjt 50 20 carriers carrier NNS cord-326015-ky4y2xjt 50 21 . . . cord-326015-ky4y2xjt 51 1 These these DT cord-326015-ky4y2xjt 51 2 form form NN cord-326015-ky4y2xjt 51 3 near near IN cord-326015-ky4y2xjt 51 4 ER ER NNP cord-326015-ky4y2xjt 51 5 exit exit NN cord-326015-ky4y2xjt 51 6 sites site NNS cord-326015-ky4y2xjt 51 7 and and CC cord-326015-ky4y2xjt 51 8 move move VB cord-326015-ky4y2xjt 51 9 towards towards IN cord-326015-ky4y2xjt 51 10 the the DT cord-326015-ky4y2xjt 51 11 microtubule microtubule NN cord-326015-ky4y2xjt 51 12 organising organise VBG cord-326015-ky4y2xjt 51 13 center center NN cord-326015-ky4y2xjt 51 14 ( ( -LRB- cord-326015-ky4y2xjt 51 15 MTOC MTOC NNP cord-326015-ky4y2xjt 51 16 ) ) -RRB- cord-326015-ky4y2xjt 51 17 where where WRB cord-326015-ky4y2xjt 51 18 they -PRON- PRP cord-326015-ky4y2xjt 51 19 are be VBP cord-326015-ky4y2xjt 51 20 seen see VBN cord-326015-ky4y2xjt 51 21 as as IN cord-326015-ky4y2xjt 51 22 stacks stack NNS cord-326015-ky4y2xjt 51 23 assembled assemble VBN cord-326015-ky4y2xjt 51 24 laterally laterally RB cord-326015-ky4y2xjt 51 25 into into IN cord-326015-ky4y2xjt 51 26 a a DT cord-326015-ky4y2xjt 51 27 Golgi Golgi NNP cord-326015-ky4y2xjt 51 28 ribbon ribbon NN cord-326015-ky4y2xjt 51 29 . . . cord-326015-ky4y2xjt 52 1 The the DT cord-326015-ky4y2xjt 52 2 number number NN cord-326015-ky4y2xjt 52 3 of of IN cord-326015-ky4y2xjt 52 4 cisternae cisternae NN cord-326015-ky4y2xjt 52 5 in in IN cord-326015-ky4y2xjt 52 6 a a DT cord-326015-ky4y2xjt 52 7 given give VBN cord-326015-ky4y2xjt 52 8 stack stack NN cord-326015-ky4y2xjt 52 9 is be VBZ cord-326015-ky4y2xjt 52 10 usually usually RB cord-326015-ky4y2xjt 52 11 3 3 CD cord-326015-ky4y2xjt 52 12 ^ ^ SYM cord-326015-ky4y2xjt 52 13 5 5 CD cord-326015-ky4y2xjt 52 14 but but CC cord-326015-ky4y2xjt 52 15 higher high JJR cord-326015-ky4y2xjt 52 16 numbers number NNS cord-326015-ky4y2xjt 52 17 have have VBP cord-326015-ky4y2xjt 52 18 been be VBN cord-326015-ky4y2xjt 52 19 observed observe VBN cord-326015-ky4y2xjt 52 20 ( ( -LRB- cord-326015-ky4y2xjt 52 21 for for IN cord-326015-ky4y2xjt 52 22 example example NN cord-326015-ky4y2xjt 52 23 , , , cord-326015-ky4y2xjt 52 24 in in IN cord-326015-ky4y2xjt 52 25 nurse nurse NN cord-326015-ky4y2xjt 52 26 cells cell NNS cord-326015-ky4y2xjt 52 27 of of IN cord-326015-ky4y2xjt 52 28 the the DT cord-326015-ky4y2xjt 52 29 insect insect NN cord-326015-ky4y2xjt 52 30 Oniscus Oniscus NNP cord-326015-ky4y2xjt 52 31 , , , cord-326015-ky4y2xjt 52 32 the the DT cord-326015-ky4y2xjt 52 33 Golgi Golgi NNP cord-326015-ky4y2xjt 52 34 stack stack NN cord-326015-ky4y2xjt 52 35 comprises comprise VBZ cord-326015-ky4y2xjt 52 36 up up IN cord-326015-ky4y2xjt 52 37 to to TO cord-326015-ky4y2xjt 52 38 36 36 CD cord-326015-ky4y2xjt 52 39 cisternae cisternae NN cord-326015-ky4y2xjt 52 40 [ [ -LRB- cord-326015-ky4y2xjt 52 41 7 7 CD cord-326015-ky4y2xjt 52 42 ] ] -RRB- cord-326015-ky4y2xjt 52 43 ) ) -RRB- cord-326015-ky4y2xjt 52 44 . . . cord-326015-ky4y2xjt 53 1 Such such JJ cord-326015-ky4y2xjt 53 2 variation variation NN cord-326015-ky4y2xjt 53 3 is be VBZ cord-326015-ky4y2xjt 53 4 permitted permit VBN cord-326015-ky4y2xjt 53 5 in in IN cord-326015-ky4y2xjt 53 6 the the DT cord-326015-ky4y2xjt 53 7 cisternal cisternal JJ cord-326015-ky4y2xjt 53 8 maturation maturation NN cord-326015-ky4y2xjt 53 9 model model NN cord-326015-ky4y2xjt 53 10 as as IN cord-326015-ky4y2xjt 53 11 new new JJ cord-326015-ky4y2xjt 53 12 cisternae cisternae NNP cord-326015-ky4y2xjt 53 13 are be VBP cord-326015-ky4y2xjt 53 14 constantly constantly RB cord-326015-ky4y2xjt 53 15 being be VBG cord-326015-ky4y2xjt 53 16 formed form VBN cord-326015-ky4y2xjt 53 17 and and CC cord-326015-ky4y2xjt 53 18 old old JJ cord-326015-ky4y2xjt 53 19 ones one NNS cord-326015-ky4y2xjt 53 20 disassembled disassemble VBN cord-326015-ky4y2xjt 53 21 at at IN cord-326015-ky4y2xjt 53 22 the the DT cord-326015-ky4y2xjt 53 23 level level NN cord-326015-ky4y2xjt 53 24 of of IN cord-326015-ky4y2xjt 53 25 the the DT cord-326015-ky4y2xjt 53 26 TGN TGN NNP cord-326015-ky4y2xjt 53 27 . . . cord-326015-ky4y2xjt 54 1 Thus thus RB cord-326015-ky4y2xjt 54 2 the the DT cord-326015-ky4y2xjt 54 3 number number NN cord-326015-ky4y2xjt 54 4 of of IN cord-326015-ky4y2xjt 54 5 cisternae cisternae NN cord-326015-ky4y2xjt 54 6 re£ects re£ect VBZ cord-326015-ky4y2xjt 54 7 the the DT cord-326015-ky4y2xjt 54 8 number number NN cord-326015-ky4y2xjt 54 9 of of IN cord-326015-ky4y2xjt 54 10 cargo cargo NN cord-326015-ky4y2xjt 54 11 carriers carrier NNS cord-326015-ky4y2xjt 54 12 put put VBD cord-326015-ky4y2xjt 54 13 through through IN cord-326015-ky4y2xjt 54 14 the the DT cord-326015-ky4y2xjt 54 15 pathway pathway NN cord-326015-ky4y2xjt 54 16 at at IN cord-326015-ky4y2xjt 54 17 the the DT cord-326015-ky4y2xjt 54 18 same same JJ cord-326015-ky4y2xjt 54 19 time time NN cord-326015-ky4y2xjt 54 20 . . . cord-326015-ky4y2xjt 55 1 As as IN cord-326015-ky4y2xjt 55 2 cargo cargo NN cord-326015-ky4y2xjt 55 3 containing contain VBG cord-326015-ky4y2xjt 55 4 cisternae cisternae NNP cord-326015-ky4y2xjt 55 5 mature mature VBP cord-326015-ky4y2xjt 55 6 forward forward RB cord-326015-ky4y2xjt 55 7 , , , cord-326015-ky4y2xjt 55 8 resident resident NN cord-326015-ky4y2xjt 55 9 proteins protein NNS cord-326015-ky4y2xjt 55 10 need need VBP cord-326015-ky4y2xjt 55 11 to to TO cord-326015-ky4y2xjt 55 12 move move VB cord-326015-ky4y2xjt 55 13 in in IN cord-326015-ky4y2xjt 55 14 the the DT cord-326015-ky4y2xjt 55 15 opposite opposite JJ cord-326015-ky4y2xjt 55 16 direction direction NN cord-326015-ky4y2xjt 55 17 . . . cord-326015-ky4y2xjt 56 1 This this DT cord-326015-ky4y2xjt 56 2 is be VBZ cord-326015-ky4y2xjt 56 3 mediated mediate VBN cord-326015-ky4y2xjt 56 4 by by IN cord-326015-ky4y2xjt 56 5 retrograde retrograde JJ cord-326015-ky4y2xjt 56 6 transport transport NN cord-326015-ky4y2xjt 56 7 carriers carrier NNS cord-326015-ky4y2xjt 56 8 ( ( -LRB- cord-326015-ky4y2xjt 56 9 RTCs RTCs NNP cord-326015-ky4y2xjt 56 10 ) ) -RRB- cord-326015-ky4y2xjt 56 11 and and CC cord-326015-ky4y2xjt 56 12 requires require VBZ cord-326015-ky4y2xjt 56 13 a a DT cord-326015-ky4y2xjt 56 14 highly highly RB cord-326015-ky4y2xjt 56 15 e¤cient e¤cient JJ cord-326015-ky4y2xjt 56 16 sorting sorting NN cord-326015-ky4y2xjt 56 17 machinery machinery NN cord-326015-ky4y2xjt 56 18 . . . cord-326015-ky4y2xjt 57 1 As as IN cord-326015-ky4y2xjt 57 2 there there EX cord-326015-ky4y2xjt 57 3 is be VBZ cord-326015-ky4y2xjt 57 4 no no DT cord-326015-ky4y2xjt 57 5 need need NN cord-326015-ky4y2xjt 57 6 to to TO cord-326015-ky4y2xjt 57 7 preserve preserve VB cord-326015-ky4y2xjt 57 8 and and CC cord-326015-ky4y2xjt 57 9 maintain maintain VB cord-326015-ky4y2xjt 57 10 compartmental compartmental JJ cord-326015-ky4y2xjt 57 11 boundaries boundary NNS cord-326015-ky4y2xjt 57 12 ( ( -LRB- cord-326015-ky4y2xjt 57 13 there there EX cord-326015-ky4y2xjt 57 14 are be VBP cord-326015-ky4y2xjt 57 15 no no DT cord-326015-ky4y2xjt 57 16 pre pre JJ cord-326015-ky4y2xjt 57 17 - - JJ cord-326015-ky4y2xjt 57 18 existing existing JJ cord-326015-ky4y2xjt 57 19 compartments compartment NNS cord-326015-ky4y2xjt 57 20 ) ) -RRB- cord-326015-ky4y2xjt 57 21 a a DT cord-326015-ky4y2xjt 57 22 simpler simple JJR cord-326015-ky4y2xjt 57 23 and and CC cord-326015-ky4y2xjt 57 24 more more RBR cord-326015-ky4y2xjt 57 25 dynamic dynamic JJ cord-326015-ky4y2xjt 57 26 sorting sorting NN cord-326015-ky4y2xjt 57 27 process process NN cord-326015-ky4y2xjt 57 28 can can MD cord-326015-ky4y2xjt 57 29 be be VB cord-326015-ky4y2xjt 57 30 envisaged envisage VBN cord-326015-ky4y2xjt 57 31 compared compare VBN cord-326015-ky4y2xjt 57 32 to to IN cord-326015-ky4y2xjt 57 33 sorting sort VBG cord-326015-ky4y2xjt 57 34 in in IN cord-326015-ky4y2xjt 57 35 the the DT cord-326015-ky4y2xjt 57 36 vesicular vesicular JJ cord-326015-ky4y2xjt 57 37 transport transport NN cord-326015-ky4y2xjt 57 38 model model NN cord-326015-ky4y2xjt 57 39 . . . cord-326015-ky4y2xjt 58 1 However however RB cord-326015-ky4y2xjt 58 2 , , , cord-326015-ky4y2xjt 58 3 it -PRON- PRP cord-326015-ky4y2xjt 58 4 is be VBZ cord-326015-ky4y2xjt 58 5 the the DT cord-326015-ky4y2xjt 58 6 process process NN cord-326015-ky4y2xjt 58 7 of of IN cord-326015-ky4y2xjt 58 8 protein protein NN cord-326015-ky4y2xjt 58 9 sorting sorting NN cord-326015-ky4y2xjt 58 10 which which WDT cord-326015-ky4y2xjt 58 11 drives drive VBZ cord-326015-ky4y2xjt 58 12 cisternal cisternal JJ cord-326015-ky4y2xjt 58 13 maturation maturation NN cord-326015-ky4y2xjt 58 14 making make VBG cord-326015-ky4y2xjt 58 15 this this DT cord-326015-ky4y2xjt 58 16 a a DT cord-326015-ky4y2xjt 58 17 fundamental fundamental JJ cord-326015-ky4y2xjt 58 18 one one NN cord-326015-ky4y2xjt 58 19 . . . cord-326015-ky4y2xjt 59 1 As as IN cord-326015-ky4y2xjt 59 2 residents resident NNS cord-326015-ky4y2xjt 59 3 in in IN cord-326015-ky4y2xjt 59 4 the the DT cord-326015-ky4y2xjt 59 5 cisternal cisternal JJ cord-326015-ky4y2xjt 59 6 maturation maturation NN cord-326015-ky4y2xjt 59 7 model model NN cord-326015-ky4y2xjt 59 8 rely rely VBP cord-326015-ky4y2xjt 59 9 on on IN cord-326015-ky4y2xjt 59 10 constant constant JJ cord-326015-ky4y2xjt 59 11 recycling recycling NN cord-326015-ky4y2xjt 59 12 , , , cord-326015-ky4y2xjt 59 13 they -PRON- PRP cord-326015-ky4y2xjt 59 14 would would MD cord-326015-ky4y2xjt 59 15 be be VB cord-326015-ky4y2xjt 59 16 predicted predict VBN cord-326015-ky4y2xjt 59 17 to to TO cord-326015-ky4y2xjt 59 18 display display VB cord-326015-ky4y2xjt 59 19 gradient gradient NN cord-326015-ky4y2xjt 59 20 - - HYPH cord-326015-ky4y2xjt 59 21 like like JJ cord-326015-ky4y2xjt 59 22 distributions distribution NNS cord-326015-ky4y2xjt 59 23 when when WRB cord-326015-ky4y2xjt 59 24 observed observe VBN cord-326015-ky4y2xjt 59 25 at at IN cord-326015-ky4y2xjt 59 26 steady steady JJ cord-326015-ky4y2xjt 59 27 state state NN cord-326015-ky4y2xjt 59 28 . . . cord-326015-ky4y2xjt 60 1 Historically historically RB cord-326015-ky4y2xjt 60 2 , , , cord-326015-ky4y2xjt 60 3 it -PRON- PRP cord-326015-ky4y2xjt 60 4 was be VBD cord-326015-ky4y2xjt 60 5 assumed assume VBN cord-326015-ky4y2xjt 60 6 that that IN cord-326015-ky4y2xjt 60 7 residents resident NNS cord-326015-ky4y2xjt 60 8 occupy occupy VBP cord-326015-ky4y2xjt 60 9 particular particular JJ cord-326015-ky4y2xjt 61 1 ( ( -LRB- cord-326015-ky4y2xjt 61 2 sub-)compartments sub-)compartment NNS cord-326015-ky4y2xjt 61 3 of of IN cord-326015-ky4y2xjt 61 4 the the DT cord-326015-ky4y2xjt 61 5 pathway pathway NN cord-326015-ky4y2xjt 61 6 and and CC cord-326015-ky4y2xjt 61 7 do do VBP cord-326015-ky4y2xjt 61 8 not not RB cord-326015-ky4y2xjt 61 9 exhibit exhibit VB cord-326015-ky4y2xjt 61 10 such such JJ cord-326015-ky4y2xjt 61 11 gradients gradient NNS cord-326015-ky4y2xjt 61 12 ( ( -LRB- cord-326015-ky4y2xjt 61 13 for for IN cord-326015-ky4y2xjt 61 14 review review NN cord-326015-ky4y2xjt 61 15 , , , cord-326015-ky4y2xjt 61 16 see see VB cord-326015-ky4y2xjt 61 17 [ [ -LRB- cord-326015-ky4y2xjt 61 18 8 8 CD cord-326015-ky4y2xjt 61 19 ] ] -RRB- cord-326015-ky4y2xjt 61 20 ) ) -RRB- cord-326015-ky4y2xjt 61 21 . . . cord-326015-ky4y2xjt 62 1 This this DT cord-326015-ky4y2xjt 62 2 dates date VBZ cord-326015-ky4y2xjt 62 3 back back RB cord-326015-ky4y2xjt 62 4 almost almost RB cord-326015-ky4y2xjt 62 5 50 50 CD cord-326015-ky4y2xjt 62 6 years year NNS cord-326015-ky4y2xjt 62 7 when when WRB cord-326015-ky4y2xjt 62 8 , , , cord-326015-ky4y2xjt 62 9 in in IN cord-326015-ky4y2xjt 62 10 1949 1949 CD cord-326015-ky4y2xjt 62 11 , , , cord-326015-ky4y2xjt 62 12 Gersh Gersh NNP cord-326015-ky4y2xjt 62 13 [ [ -LRB- cord-326015-ky4y2xjt 62 14 9 9 CD cord-326015-ky4y2xjt 62 15 ] ] -RRB- cord-326015-ky4y2xjt 62 16 suggested suggest VBN cord-326015-ky4y2xjt 62 17 that`it that`it NNP cord-326015-ky4y2xjt 62 18 may may MD cord-326015-ky4y2xjt 62 19 be be VB cord-326015-ky4y2xjt 62 20 possible possible JJ cord-326015-ky4y2xjt 62 21 to to TO cord-326015-ky4y2xjt 62 22 conceive conceive VB cord-326015-ky4y2xjt 62 23 of of IN cord-326015-ky4y2xjt 62 24 the the DT cord-326015-ky4y2xjt 62 25 Golgi Golgi NNP cord-326015-ky4y2xjt 62 26 apparatus apparatus NN cord-326015-ky4y2xjt 62 27 as as IN cord-326015-ky4y2xjt 62 28 a a DT cord-326015-ky4y2xjt 62 29 framework framework NN cord-326015-ky4y2xjt 62 30 whose whose WP$ cord-326015-ky4y2xjt 62 31 structure structure NN cord-326015-ky4y2xjt 62 32 is be VBZ cord-326015-ky4y2xjt 62 33 of of IN cord-326015-ky4y2xjt 62 34 such such JJ cord-326015-ky4y2xjt 62 35 nature nature NN cord-326015-ky4y2xjt 62 36 that that IN cord-326015-ky4y2xjt 62 37 it -PRON- PRP cord-326015-ky4y2xjt 62 38 may may MD cord-326015-ky4y2xjt 62 39 accommodate accommodate VB cord-326015-ky4y2xjt 62 40 certain certain JJ cord-326015-ky4y2xjt 62 41 enzymes enzyme NNS cord-326015-ky4y2xjt 62 42 or or CC cord-326015-ky4y2xjt 62 43 other other JJ cord-326015-ky4y2xjt 62 44 activities activity NNS cord-326015-ky4y2xjt 62 45 in in IN cord-326015-ky4y2xjt 62 46 an an DT cord-326015-ky4y2xjt 62 47 orderly orderly JJ cord-326015-ky4y2xjt 62 48 manner manner NN cord-326015-ky4y2xjt 62 49 ' ' '' cord-326015-ky4y2xjt 62 50 . . . cord-326015-ky4y2xjt 63 1 This this DT cord-326015-ky4y2xjt 63 2 was be VBD cord-326015-ky4y2xjt 63 3 based base VBN cord-326015-ky4y2xjt 63 4 on on IN cord-326015-ky4y2xjt 63 5 the the DT cord-326015-ky4y2xjt 63 6 fundamental fundamental JJ cord-326015-ky4y2xjt 63 7 observation observation NN cord-326015-ky4y2xjt 63 8 that that IN cord-326015-ky4y2xjt 63 9 the the DT cord-326015-ky4y2xjt 63 10 Golgi Golgi NNP cord-326015-ky4y2xjt 63 11 apparatus apparatus NN cord-326015-ky4y2xjt 63 12 is be VBZ cord-326015-ky4y2xjt 63 13 directly directly RB cord-326015-ky4y2xjt 63 14 involved involve VBN cord-326015-ky4y2xjt 63 15 in in IN cord-326015-ky4y2xjt 63 16 the the DT cord-326015-ky4y2xjt 63 17 processing processing NN cord-326015-ky4y2xjt 63 18 of of IN cord-326015-ky4y2xjt 63 19 carbohydrates carbohydrate NNS cord-326015-ky4y2xjt 63 20 ( ( -LRB- cord-326015-ky4y2xjt 63 21 con¢rmed con¢rme VBN cord-326015-ky4y2xjt 63 22 shortly shortly RB cord-326015-ky4y2xjt 63 23 after after IN cord-326015-ky4y2xjt 63 24 by by IN cord-326015-ky4y2xjt 63 25 Leblond Leblond NNP cord-326015-ky4y2xjt 63 26 , , , cord-326015-ky4y2xjt 63 27 1950 1950 CD cord-326015-ky4y2xjt 63 28 [ [ -LRB- cord-326015-ky4y2xjt 63 29 10 10 CD cord-326015-ky4y2xjt 63 30 ] ] -RRB- cord-326015-ky4y2xjt 63 31 ) ) -RRB- cord-326015-ky4y2xjt 63 32 . . . cord-326015-ky4y2xjt 64 1 This this DT cord-326015-ky4y2xjt 64 2 was be VBD cord-326015-ky4y2xjt 64 3 done do VBN cord-326015-ky4y2xjt 64 4 well well RB cord-326015-ky4y2xjt 64 5 before before IN cord-326015-ky4y2xjt 64 6 the the DT cord-326015-ky4y2xjt 64 7 use use NN cord-326015-ky4y2xjt 64 8 of of IN cord-326015-ky4y2xjt 64 9 electron electron NN cord-326015-ky4y2xjt 64 10 microscopy microscopy NN cord-326015-ky4y2xjt 64 11 revealing reveal VBG cord-326015-ky4y2xjt 64 12 the the DT cord-326015-ky4y2xjt 64 13 cisternal cisternal JJ cord-326015-ky4y2xjt 64 14 - - HYPH cord-326015-ky4y2xjt 64 15 like like JJ cord-326015-ky4y2xjt 64 16 structures structure NNS cord-326015-ky4y2xjt 64 17 of of IN cord-326015-ky4y2xjt 64 18 the the DT cord-326015-ky4y2xjt 64 19 Golgi Golgi NNP cord-326015-ky4y2xjt 64 20 stack stack NN cord-326015-ky4y2xjt 64 21 . . . cord-326015-ky4y2xjt 65 1 Nevertheless nevertheless RB cord-326015-ky4y2xjt 65 2 , , , cord-326015-ky4y2xjt 65 3 it -PRON- PRP cord-326015-ky4y2xjt 65 4 set set VBD cord-326015-ky4y2xjt 65 5 the the DT cord-326015-ky4y2xjt 65 6 stage stage NN cord-326015-ky4y2xjt 65 7 for for IN cord-326015-ky4y2xjt 65 8 a a DT cord-326015-ky4y2xjt 65 9 view view NN cord-326015-ky4y2xjt 65 10 which which WDT cord-326015-ky4y2xjt 65 11 prevails prevail VBZ cord-326015-ky4y2xjt 65 12 even even RB cord-326015-ky4y2xjt 65 13 today today NN cord-326015-ky4y2xjt 65 14 that that IN cord-326015-ky4y2xjt 65 15 cisternae cisternae NNP cord-326015-ky4y2xjt 65 16 contain contain VBP cord-326015-ky4y2xjt 65 17 separate separate JJ cord-326015-ky4y2xjt 65 18 sets set NNS cord-326015-ky4y2xjt 65 19 of of IN cord-326015-ky4y2xjt 65 20 modifying modify VBG cord-326015-ky4y2xjt 65 21 enzymes enzyme NNS cord-326015-ky4y2xjt 65 22 . . . cord-326015-ky4y2xjt 66 1 As as IN cord-326015-ky4y2xjt 66 2 Golgi Golgi NNP cord-326015-ky4y2xjt 66 3 cisternae cisternae NNP cord-326015-ky4y2xjt 66 4 di¡er di¡er NNS cord-326015-ky4y2xjt 66 5 slightly slightly RB cord-326015-ky4y2xjt 66 6 in in IN cord-326015-ky4y2xjt 66 7 density density NN cord-326015-ky4y2xjt 66 8 , , , cord-326015-ky4y2xjt 66 9 from from IN cord-326015-ky4y2xjt 66 10 earlier early JJR cord-326015-ky4y2xjt 66 11 ones one NNS cord-326015-ky4y2xjt 66 12 being be VBG cord-326015-ky4y2xjt 66 13 heavier heavy JJR cord-326015-ky4y2xjt 66 14 to to IN cord-326015-ky4y2xjt 66 15 later later JJ cord-326015-ky4y2xjt 66 16 ones one NNS cord-326015-ky4y2xjt 66 17 being be VBG cord-326015-ky4y2xjt 66 18 lighter light JJR cord-326015-ky4y2xjt 66 19 , , , cord-326015-ky4y2xjt 66 20 subcellular subcellular JJ cord-326015-ky4y2xjt 66 21 fractionation fractionation NN cord-326015-ky4y2xjt 66 22 did do VBD cord-326015-ky4y2xjt 66 23 indeed indeed RB cord-326015-ky4y2xjt 66 24 con¢rm con¢rm VB cord-326015-ky4y2xjt 66 25 this this DT cord-326015-ky4y2xjt 66 26 , , , cord-326015-ky4y2xjt 66 27 demonstrating demonstrate VBG cord-326015-ky4y2xjt 66 28 that that IN cord-326015-ky4y2xjt 66 29 enzymatic enzymatic JJ cord-326015-ky4y2xjt 66 30 activities activity NNS cord-326015-ky4y2xjt 66 31 could could MD cord-326015-ky4y2xjt 66 32 be be VB cord-326015-ky4y2xjt 66 33 separated separate VBN cord-326015-ky4y2xjt 66 34 from from IN cord-326015-ky4y2xjt 66 35 each each DT cord-326015-ky4y2xjt 66 36 other other JJ cord-326015-ky4y2xjt 66 37 ( ( -LRB- cord-326015-ky4y2xjt 66 38 although although IN cord-326015-ky4y2xjt 66 39 only only RB cord-326015-ky4y2xjt 66 40 partially partially RB cord-326015-ky4y2xjt 66 41 ; ; : cord-326015-ky4y2xjt 66 42 [ [ -LRB- cord-326015-ky4y2xjt 66 43 11 11 CD cord-326015-ky4y2xjt 66 44 , , , cord-326015-ky4y2xjt 66 45 12 12 CD cord-326015-ky4y2xjt 66 46 ] ] -RRB- cord-326015-ky4y2xjt 66 47 ) ) -RRB- cord-326015-ky4y2xjt 66 48 . . . cord-326015-ky4y2xjt 67 1 This this DT cord-326015-ky4y2xjt 67 2 was be VBD cord-326015-ky4y2xjt 67 3 also also RB cord-326015-ky4y2xjt 67 4 shown show VBN cord-326015-ky4y2xjt 67 5 at at IN cord-326015-ky4y2xjt 67 6 the the DT cord-326015-ky4y2xjt 67 7 ultrastructural ultrastructural JJ cord-326015-ky4y2xjt 67 8 level level NN cord-326015-ky4y2xjt 67 9 revealing reveal VBG cord-326015-ky4y2xjt 67 10 either either CC cord-326015-ky4y2xjt 67 11 the the DT cord-326015-ky4y2xjt 67 12 location location NN cord-326015-ky4y2xjt 67 13 of of IN cord-326015-ky4y2xjt 67 14 a a DT cord-326015-ky4y2xjt 67 15 particular particular JJ cord-326015-ky4y2xjt 67 16 enzyme enzyme NN cord-326015-ky4y2xjt 67 17 or or CC cord-326015-ky4y2xjt 67 18 its -PRON- PRP$ cord-326015-ky4y2xjt 67 19 product product NN cord-326015-ky4y2xjt 67 20 ( ( -LRB- cord-326015-ky4y2xjt 67 21 using use VBG cord-326015-ky4y2xjt 67 22 lectins lectin NNS cord-326015-ky4y2xjt 67 23 ) ) -RRB- cord-326015-ky4y2xjt 67 24 ( ( -LRB- cord-326015-ky4y2xjt 67 25 for for IN cord-326015-ky4y2xjt 67 26 a a DT cord-326015-ky4y2xjt 67 27 comprehensive comprehensive JJ cord-326015-ky4y2xjt 67 28 review review NN cord-326015-ky4y2xjt 67 29 , , , cord-326015-ky4y2xjt 67 30 see see VB cord-326015-ky4y2xjt 67 31 [ [ -LRB- cord-326015-ky4y2xjt 67 32 13 13 CD cord-326015-ky4y2xjt 67 33 ] ] -RRB- cord-326015-ky4y2xjt 67 34 ) ) -RRB- cord-326015-ky4y2xjt 67 35 . . . cord-326015-ky4y2xjt 68 1 The the DT cord-326015-ky4y2xjt 68 2 ¢rst ¢rst CD cord-326015-ky4y2xjt 68 3 resident resident NN cord-326015-ky4y2xjt 68 4 of of IN cord-326015-ky4y2xjt 68 5 the the DT cord-326015-ky4y2xjt 68 6 Golgi Golgi NNP cord-326015-ky4y2xjt 68 7 apparatus apparatus NN cord-326015-ky4y2xjt 68 8 to to TO cord-326015-ky4y2xjt 68 9 be be VB cord-326015-ky4y2xjt 68 10 mapped map VBN cord-326015-ky4y2xjt 68 11 at at IN cord-326015-ky4y2xjt 68 12 this this DT cord-326015-ky4y2xjt 68 13 level level NN cord-326015-ky4y2xjt 68 14 was be VBD cord-326015-ky4y2xjt 68 15 the the DT cord-326015-ky4y2xjt 68 16 glycosylation glycosylation NN cord-326015-ky4y2xjt 68 17 enzyme enzyme NN cord-326015-ky4y2xjt 68 18 L1,4-galactosyltransferase L1,4-galactosyltransferase NNP cord-326015-ky4y2xjt 68 19 ( ( -LRB- cord-326015-ky4y2xjt 68 20 GalT GalT NNP cord-326015-ky4y2xjt 68 21 ) ) -RRB- cord-326015-ky4y2xjt 68 22 which which WDT cord-326015-ky4y2xjt 68 23 was be VBD cord-326015-ky4y2xjt 68 24 shown show VBN cord-326015-ky4y2xjt 68 25 to to TO cord-326015-ky4y2xjt 68 26 reside reside VB cord-326015-ky4y2xjt 68 27 in in IN cord-326015-ky4y2xjt 68 28 the the DT cord-326015-ky4y2xjt 68 29 trans trans NNP cord-326015-ky4y2xjt 68 30 cisternae cisternae NNP cord-326015-ky4y2xjt 68 31 [ [ -LRB- cord-326015-ky4y2xjt 68 32 14 14 CD cord-326015-ky4y2xjt 68 33 ] ] -RRB- cord-326015-ky4y2xjt 68 34 and and CC cord-326015-ky4y2xjt 68 35 this this DT cord-326015-ky4y2xjt 68 36 was be VBD cord-326015-ky4y2xjt 68 37 followed follow VBN cord-326015-ky4y2xjt 68 38 by by IN cord-326015-ky4y2xjt 68 39 the the DT cord-326015-ky4y2xjt 68 40 mapping mapping NN cord-326015-ky4y2xjt 68 41 of of IN cord-326015-ky4y2xjt 68 42 K2,6-sialyltransferase K2,6-sialyltransferase NNP cord-326015-ky4y2xjt 68 43 ( ( -LRB- cord-326015-ky4y2xjt 68 44 Sia Sia NNP cord-326015-ky4y2xjt 68 45 - - HYPH cord-326015-ky4y2xjt 68 46 lylT lylT NNP cord-326015-ky4y2xjt 68 47 ) ) -RRB- cord-326015-ky4y2xjt 68 48 to to IN cord-326015-ky4y2xjt 68 49 the the DT cord-326015-ky4y2xjt 68 50 TGN TGN NNP cord-326015-ky4y2xjt 68 51 [ [ -LRB- cord-326015-ky4y2xjt 68 52 15 15 CD cord-326015-ky4y2xjt 68 53 ] ] -RRB- cord-326015-ky4y2xjt 68 54 . . . cord-326015-ky4y2xjt 69 1 As as IN cord-326015-ky4y2xjt 69 2 both both DT cord-326015-ky4y2xjt 69 3 GalT GalT NNP cord-326015-ky4y2xjt 69 4 and and CC cord-326015-ky4y2xjt 69 5 SialylT SialylT NNP cord-326015-ky4y2xjt 69 6 add add VB cord-326015-ky4y2xjt 69 7 terminal terminal JJ cord-326015-ky4y2xjt 69 8 monosaccharides monosaccharide NNS cord-326015-ky4y2xjt 69 9 to to IN cord-326015-ky4y2xjt 69 10 glycoproteins glycoprotein NNS cord-326015-ky4y2xjt 69 11 with with IN cord-326015-ky4y2xjt 69 12 complex complex JJ cord-326015-ky4y2xjt 69 13 N n CD cord-326015-ky4y2xjt 69 14 - - HYPH cord-326015-ky4y2xjt 69 15 linked link VBN cord-326015-ky4y2xjt 69 16 structures structure NNS cord-326015-ky4y2xjt 69 17 , , , cord-326015-ky4y2xjt 69 18 there there EX cord-326015-ky4y2xjt 69 19 was be VBD cord-326015-ky4y2xjt 69 20 clearly clearly RB cord-326015-ky4y2xjt 69 21 a a DT cord-326015-ky4y2xjt 69 22 correlation correlation NN cord-326015-ky4y2xjt 69 23 between between IN cord-326015-ky4y2xjt 69 24 function function NN cord-326015-ky4y2xjt 69 25 and and CC cord-326015-ky4y2xjt 69 26 localisation localisation NN cord-326015-ky4y2xjt 69 27 . . . cord-326015-ky4y2xjt 70 1 Two two CD cord-326015-ky4y2xjt 70 2 other other JJ cord-326015-ky4y2xjt 70 3 enzymes enzyme NNS cord-326015-ky4y2xjt 70 4 , , , cord-326015-ky4y2xjt 70 5 L1,2-N L1,2-N '' cord-326015-ky4y2xjt 70 6 - - HYPH cord-326015-ky4y2xjt 70 7 acetylglucosaminyltransferase acetylglucosaminyltransferase NNP cord-326015-ky4y2xjt 71 1 I -PRON- PRP cord-326015-ky4y2xjt 71 2 ( ( -LRB- cord-326015-ky4y2xjt 71 3 NAGT NAGT NNP cord-326015-ky4y2xjt 71 4 I I NNP cord-326015-ky4y2xjt 71 5 ) ) -RRB- cord-326015-ky4y2xjt 71 6 and and CC cord-326015-ky4y2xjt 71 7 K1,3 K1,3 NNP cord-326015-ky4y2xjt 71 8 - - HYPH cord-326015-ky4y2xjt 71 9 1,6 1,6 CD cord-326015-ky4y2xjt 71 10 mannosidase mannosidase NN cord-326015-ky4y2xjt 71 11 II II NNP cord-326015-ky4y2xjt 71 12 ( ( -LRB- cord-326015-ky4y2xjt 71 13 Mann Mann NNP cord-326015-ky4y2xjt 71 14 II II NNP cord-326015-ky4y2xjt 71 15 ) ) -RRB- cord-326015-ky4y2xjt 71 16 , , , cord-326015-ky4y2xjt 71 17 both both DT cord-326015-ky4y2xjt 71 18 acting act VBG cord-326015-ky4y2xjt 71 19 earlier early RBR cord-326015-ky4y2xjt 71 20 , , , cord-326015-ky4y2xjt 71 21 were be VBD cord-326015-ky4y2xjt 71 22 subsequently subsequently RB cord-326015-ky4y2xjt 71 23 found find VBN cord-326015-ky4y2xjt 71 24 in in IN cord-326015-ky4y2xjt 71 25 medial medial JJ cord-326015-ky4y2xjt 71 26 cisternae cisternae NNP cord-326015-ky4y2xjt 71 27 [ [ -LRB- cord-326015-ky4y2xjt 71 28 16 16 CD cord-326015-ky4y2xjt 71 29 , , , cord-326015-ky4y2xjt 71 30 17 17 CD cord-326015-ky4y2xjt 71 31 ] ] -RRB- cord-326015-ky4y2xjt 71 32 . . . cord-326015-ky4y2xjt 72 1 As as IN cord-326015-ky4y2xjt 72 2 these these DT cord-326015-ky4y2xjt 72 3 enzymes enzyme NNS cord-326015-ky4y2xjt 72 4 were be VBD cord-326015-ky4y2xjt 72 5 found find VBN cord-326015-ky4y2xjt 72 6 in in IN cord-326015-ky4y2xjt 72 7 more more JJR cord-326015-ky4y2xjt 72 8 than than IN cord-326015-ky4y2xjt 72 9 one one CD cord-326015-ky4y2xjt 72 10 cisterna cisterna NN cord-326015-ky4y2xjt 72 11 , , , cord-326015-ky4y2xjt 72 12 this this DT cord-326015-ky4y2xjt 72 13 was be VBD cord-326015-ky4y2xjt 72 14 taken take VBN cord-326015-ky4y2xjt 72 15 as as IN cord-326015-ky4y2xjt 72 16 evidence evidence NN cord-326015-ky4y2xjt 72 17 for for IN cord-326015-ky4y2xjt 72 18 cisternal cisternal JJ cord-326015-ky4y2xjt 72 19 duplication duplication NN cord-326015-ky4y2xjt 72 20 . . . cord-326015-ky4y2xjt 73 1 The the DT cord-326015-ky4y2xjt 73 2 ¢nding ¢nding NN cord-326015-ky4y2xjt 73 3 that that IN cord-326015-ky4y2xjt 73 4 NAGT NAGT NNP cord-326015-ky4y2xjt 73 5 I -PRON- PRP cord-326015-ky4y2xjt 73 6 and and CC cord-326015-ky4y2xjt 73 7 GalT GalT NNP cord-326015-ky4y2xjt 73 8 were be VBD cord-326015-ky4y2xjt 73 9 present present JJ cord-326015-ky4y2xjt 73 10 together together RB cord-326015-ky4y2xjt 73 11 in in IN cord-326015-ky4y2xjt 73 12 one one CD cord-326015-ky4y2xjt 73 13 cisterna cisterna NNP cord-326015-ky4y2xjt 73 14 but but CC cord-326015-ky4y2xjt 73 15 separately separately RB cord-326015-ky4y2xjt 73 16 in in IN cord-326015-ky4y2xjt 73 17 adjacent adjacent JJ cord-326015-ky4y2xjt 73 18 ones one NNS cord-326015-ky4y2xjt 73 19 argued argue VBD cord-326015-ky4y2xjt 73 20 that that IN cord-326015-ky4y2xjt 73 21 rather rather RB cord-326015-ky4y2xjt 73 22 than than IN cord-326015-ky4y2xjt 73 23 having have VBG cord-326015-ky4y2xjt 73 24 unique unique JJ cord-326015-ky4y2xjt 73 25 sets set NNS cord-326015-ky4y2xjt 73 26 of of IN cord-326015-ky4y2xjt 73 27 enzymes enzyme NNS cord-326015-ky4y2xjt 73 28 , , , cord-326015-ky4y2xjt 73 29 cisternae cisternae NNP cord-326015-ky4y2xjt 73 30 contained contain VBD cord-326015-ky4y2xjt 73 31 unique unique JJ cord-326015-ky4y2xjt 73 32 mixtures mixture NNS cord-326015-ky4y2xjt 73 33 [ [ -LRB- cord-326015-ky4y2xjt 73 34 18 18 CD cord-326015-ky4y2xjt 73 35 ] ] -RRB- cord-326015-ky4y2xjt 73 36 . . . cord-326015-ky4y2xjt 74 1 This this DT cord-326015-ky4y2xjt 74 2 observation observation NN cord-326015-ky4y2xjt 74 3 was be VBD cord-326015-ky4y2xjt 74 4 later later RB cord-326015-ky4y2xjt 74 5 extended extend VBN cord-326015-ky4y2xjt 74 6 to to TO cord-326015-ky4y2xjt 74 7 include include VB cord-326015-ky4y2xjt 74 8 all all DT cord-326015-ky4y2xjt 74 9 four four CD cord-326015-ky4y2xjt 74 10 enzymes enzyme NNS cord-326015-ky4y2xjt 74 11 , , , cord-326015-ky4y2xjt 74 12 NAGT NAGT NNP cord-326015-ky4y2xjt 74 13 I I NNP cord-326015-ky4y2xjt 74 14 , , , cord-326015-ky4y2xjt 74 15 Mann Mann NNP cord-326015-ky4y2xjt 74 16 II II NNP cord-326015-ky4y2xjt 74 17 , , , cord-326015-ky4y2xjt 74 18 GalT GalT NNP cord-326015-ky4y2xjt 74 19 and and CC cord-326015-ky4y2xjt 74 20 SialylT sialylt RB cord-326015-ky4y2xjt 74 21 demonstrating demonstrate VBG cord-326015-ky4y2xjt 74 22 overlapping overlap VBG cord-326015-ky4y2xjt 74 23 distributions distribution NNS cord-326015-ky4y2xjt 74 24 for for IN cord-326015-ky4y2xjt 74 25 all all DT cord-326015-ky4y2xjt 74 26 four four CD cord-326015-ky4y2xjt 74 27 enzymes enzyme NNS cord-326015-ky4y2xjt 74 28 [ [ -LRB- cord-326015-ky4y2xjt 74 29 19 19 CD cord-326015-ky4y2xjt 74 30 ] ] -RRB- cord-326015-ky4y2xjt 74 31 . . . cord-326015-ky4y2xjt 75 1 Formation formation NN cord-326015-ky4y2xjt 75 2 of of IN cord-326015-ky4y2xjt 75 3 gradients gradient NNS cord-326015-ky4y2xjt 75 4 was be VBD cord-326015-ky4y2xjt 75 5 also also RB cord-326015-ky4y2xjt 75 6 suggested suggest VBN cord-326015-ky4y2xjt 75 7 from from IN cord-326015-ky4y2xjt 75 8 low low JJ cord-326015-ky4y2xjt 75 9 but but CC cord-326015-ky4y2xjt 75 10 signi¢cant signi¢cant CD cord-326015-ky4y2xjt 75 11 amounts amount NNS cord-326015-ky4y2xjt 75 12 of of IN cord-326015-ky4y2xjt 75 13 enzymes enzyme NNS cord-326015-ky4y2xjt 75 14 in in IN cord-326015-ky4y2xjt 75 15 more more RBR cord-326015-ky4y2xjt 75 16 distal distal JJ cord-326015-ky4y2xjt 75 17 cisternae cisternae NN cord-326015-ky4y2xjt 75 18 . . . cord-326015-ky4y2xjt 76 1 This this DT cord-326015-ky4y2xjt 76 2 was be VBD cord-326015-ky4y2xjt 76 3 more more RBR cord-326015-ky4y2xjt 76 4 obvious obvious JJ cord-326015-ky4y2xjt 76 5 when when WRB cord-326015-ky4y2xjt 76 6 examining examine VBG cord-326015-ky4y2xjt 76 7 the the DT cord-326015-ky4y2xjt 76 8 distribution distribution NN cord-326015-ky4y2xjt 76 9 of of IN cord-326015-ky4y2xjt 76 10 three three CD cord-326015-ky4y2xjt 76 11 enzymes enzyme NNS cord-326015-ky4y2xjt 76 12 involved involve VBN cord-326015-ky4y2xjt 76 13 in in IN cord-326015-ky4y2xjt 76 14 initiation initiation NN cord-326015-ky4y2xjt 76 15 of of IN cord-326015-ky4y2xjt 76 16 O o NN cord-326015-ky4y2xjt 76 17 - - HYPH cord-326015-ky4y2xjt 76 18 linked link VBN cord-326015-ky4y2xjt 76 19 glycosylation glycosylation NN cord-326015-ky4y2xjt 76 20 . . . cord-326015-ky4y2xjt 77 1 N N NNP cord-326015-ky4y2xjt 77 2 - - HYPH cord-326015-ky4y2xjt 77 3 Acetylgalactosaminyltransferase Acetylgalactosaminyltransferase NNP cord-326015-ky4y2xjt 77 4 - - HYPH cord-326015-ky4y2xjt 77 5 T1 T1 NNP cord-326015-ky4y2xjt 77 6 , , , cord-326015-ky4y2xjt 77 7 -T2 -T2 VBD cord-326015-ky4y2xjt 78 1 and and CC cord-326015-ky4y2xjt 78 2 -T3 -t3 PRP cord-326015-ky4y2xjt 78 3 were be VBD cord-326015-ky4y2xjt 78 4 all all DT cord-326015-ky4y2xjt 78 5 found find VBN cord-326015-ky4y2xjt 78 6 throughout throughout IN cord-326015-ky4y2xjt 78 7 the the DT cord-326015-ky4y2xjt 78 8 Golgi Golgi NNP cord-326015-ky4y2xjt 78 9 stack stack NN cord-326015-ky4y2xjt 78 10 as as IN cord-326015-ky4y2xjt 78 11 distinct distinct JJ cord-326015-ky4y2xjt 78 12 gradients gradient NNS cord-326015-ky4y2xjt 78 13 [ [ -LRB- cord-326015-ky4y2xjt 78 14 20 20 CD cord-326015-ky4y2xjt 78 15 ] ] -RRB- cord-326015-ky4y2xjt 78 16 . . . cord-326015-ky4y2xjt 79 1 This this DT cord-326015-ky4y2xjt 79 2 shows show VBZ cord-326015-ky4y2xjt 79 3 that that IN cord-326015-ky4y2xjt 79 4 Golgi Golgi NNP cord-326015-ky4y2xjt 79 5 resident resident NN cord-326015-ky4y2xjt 79 6 enzymes enzyme NNS cord-326015-ky4y2xjt 79 7 do do VBP cord-326015-ky4y2xjt 79 8 form form NN cord-326015-ky4y2xjt 79 9 gradients gradient NNS cord-326015-ky4y2xjt 79 10 across across IN cord-326015-ky4y2xjt 79 11 the the DT cord-326015-ky4y2xjt 79 12 pathway pathway NN cord-326015-ky4y2xjt 79 13 and and CC cord-326015-ky4y2xjt 79 14 that that IN cord-326015-ky4y2xjt 79 15 these these DT cord-326015-ky4y2xjt 79 16 are be VBP cord-326015-ky4y2xjt 79 17 unique unique JJ cord-326015-ky4y2xjt 79 18 to to IN cord-326015-ky4y2xjt 79 19 the the DT cord-326015-ky4y2xjt 79 20 particular particular JJ cord-326015-ky4y2xjt 79 21 protein protein NN cord-326015-ky4y2xjt 79 22 . . . cord-326015-ky4y2xjt 80 1 The the DT cord-326015-ky4y2xjt 80 2 constant constant JJ cord-326015-ky4y2xjt 80 3 recycling recycling NN cord-326015-ky4y2xjt 80 4 of of IN cord-326015-ky4y2xjt 80 5 residents resident NNS cord-326015-ky4y2xjt 80 6 via via IN cord-326015-ky4y2xjt 80 7 RTCs RTCs NNP cord-326015-ky4y2xjt 80 8 ensures ensure VBZ cord-326015-ky4y2xjt 80 9 that that IN cord-326015-ky4y2xjt 80 10 these these DT cord-326015-ky4y2xjt 80 11 are be VBP cord-326015-ky4y2xjt 80 12 maintained maintain VBN cord-326015-ky4y2xjt 80 13 in in IN cord-326015-ky4y2xjt 80 14 the the DT cord-326015-ky4y2xjt 80 15 pathway pathway NN cord-326015-ky4y2xjt 80 16 . . . cord-326015-ky4y2xjt 81 1 However however RB cord-326015-ky4y2xjt 81 2 , , , cord-326015-ky4y2xjt 81 3 it -PRON- PRP cord-326015-ky4y2xjt 81 4 does do VBZ cord-326015-ky4y2xjt 81 5 not not RB cord-326015-ky4y2xjt 81 6 explain explain VB cord-326015-ky4y2xjt 81 7 how how WRB cord-326015-ky4y2xjt 81 8 residents resident NNS cord-326015-ky4y2xjt 81 9 exhibit exhibit VBP cord-326015-ky4y2xjt 81 10 di¡erential di¡erential JJ cord-326015-ky4y2xjt 81 11 gradients gradient NNS cord-326015-ky4y2xjt 81 12 in in IN cord-326015-ky4y2xjt 81 13 such such PDT cord-326015-ky4y2xjt 81 14 a a DT cord-326015-ky4y2xjt 81 15 way way NN cord-326015-ky4y2xjt 81 16 that that WDT cord-326015-ky4y2xjt 81 17 enzymes enzyme NNS cord-326015-ky4y2xjt 81 18 such such JJ cord-326015-ky4y2xjt 81 19 as as IN cord-326015-ky4y2xjt 81 20 GalT GalT NNP cord-326015-ky4y2xjt 81 21 are be VBP cord-326015-ky4y2xjt 81 22 found find VBN cord-326015-ky4y2xjt 81 23 later later RB cord-326015-ky4y2xjt 81 24 than than IN cord-326015-ky4y2xjt 81 25 for for IN cord-326015-ky4y2xjt 81 26 example example NN cord-326015-ky4y2xjt 81 27 NAGT NAGT NNP cord-326015-ky4y2xjt 81 28 I. I. NNP cord-326015-ky4y2xjt 82 1 To to TO cord-326015-ky4y2xjt 82 2 explain explain VB cord-326015-ky4y2xjt 82 3 this this DT cord-326015-ky4y2xjt 82 4 , , , cord-326015-ky4y2xjt 82 5 Glick Glick NNP cord-326015-ky4y2xjt 82 6 and and CC cord-326015-ky4y2xjt 82 7 co co NNS cord-326015-ky4y2xjt 82 8 - - NNS cord-326015-ky4y2xjt 82 9 workers worker NNS cord-326015-ky4y2xjt 82 10 [ [ -LRB- cord-326015-ky4y2xjt 82 11 21 21 CD cord-326015-ky4y2xjt 82 12 ] ] -RRB- cord-326015-ky4y2xjt 82 13 proposed propose VBD cord-326015-ky4y2xjt 82 14 an an DT cord-326015-ky4y2xjt 82 15 elegant elegant JJ cord-326015-ky4y2xjt 82 16 yet yet CC cord-326015-ky4y2xjt 82 17 simple simple JJ cord-326015-ky4y2xjt 82 18 hypothesis hypothesis NN cord-326015-ky4y2xjt 82 19 suggesting suggest VBG cord-326015-ky4y2xjt 82 20 that that IN cord-326015-ky4y2xjt 82 21 residents resident NNS cord-326015-ky4y2xjt 82 22 have have VBP cord-326015-ky4y2xjt 82 23 di¡erential di¡erential JJ cord-326015-ky4y2xjt 82 24 abilities ability NNS cord-326015-ky4y2xjt 82 25 to to TO cord-326015-ky4y2xjt 82 26 enter enter VB cord-326015-ky4y2xjt 82 27 RTCs rtc NNS cord-326015-ky4y2xjt 82 28 . . . cord-326015-ky4y2xjt 83 1 Furthermore furthermore RB cord-326015-ky4y2xjt 83 2 , , , cord-326015-ky4y2xjt 83 3 they -PRON- PRP cord-326015-ky4y2xjt 83 4 showed show VBD cord-326015-ky4y2xjt 83 5 that that IN cord-326015-ky4y2xjt 83 6 if if IN cord-326015-ky4y2xjt 83 7 this this DT cord-326015-ky4y2xjt 83 8 was be VBD cord-326015-ky4y2xjt 83 9 the the DT cord-326015-ky4y2xjt 83 10 case case NN cord-326015-ky4y2xjt 83 11 , , , cord-326015-ky4y2xjt 83 12 competition competition NN cord-326015-ky4y2xjt 83 13 between between IN cord-326015-ky4y2xjt 83 14 di¡erent di¡erent NNP cord-326015-ky4y2xjt 83 15 residents resident NNS cord-326015-ky4y2xjt 83 16 is be VBZ cord-326015-ky4y2xjt 83 17 su¤cient su¤cient NNP cord-326015-ky4y2xjt 83 18 to to TO cord-326015-ky4y2xjt 83 19 establish establish VB cord-326015-ky4y2xjt 83 20 and and CC cord-326015-ky4y2xjt 83 21 maintain maintain VB cord-326015-ky4y2xjt 83 22 gradients gradient NNS cord-326015-ky4y2xjt 83 23 in in IN cord-326015-ky4y2xjt 83 24 the the DT cord-326015-ky4y2xjt 83 25 context context NN cord-326015-ky4y2xjt 83 26 of of IN cord-326015-ky4y2xjt 83 27 cisternal cisternal JJ cord-326015-ky4y2xjt 83 28 maturation maturation NN cord-326015-ky4y2xjt 83 29 . . . cord-326015-ky4y2xjt 84 1 Residents resident NNS cord-326015-ky4y2xjt 84 2 with with IN cord-326015-ky4y2xjt 84 3 a a DT cord-326015-ky4y2xjt 84 4 high high JJ cord-326015-ky4y2xjt 84 5 ability ability NN cord-326015-ky4y2xjt 84 6 to to TO cord-326015-ky4y2xjt 84 7 enter enter VB cord-326015-ky4y2xjt 84 8 RTCs rtc NNS cord-326015-ky4y2xjt 84 9 would would MD cord-326015-ky4y2xjt 84 10 be be VB cord-326015-ky4y2xjt 84 11 found find VBN cord-326015-ky4y2xjt 84 12 in in IN cord-326015-ky4y2xjt 84 13 early early JJ cord-326015-ky4y2xjt 84 14 compartments compartment NNS cord-326015-ky4y2xjt 84 15 whereas whereas IN cord-326015-ky4y2xjt 84 16 those those DT cord-326015-ky4y2xjt 84 17 with with IN cord-326015-ky4y2xjt 84 18 a a DT cord-326015-ky4y2xjt 84 19 lower low JJR cord-326015-ky4y2xjt 84 20 ability ability NN cord-326015-ky4y2xjt 84 21 would would MD cord-326015-ky4y2xjt 84 22 be be VB cord-326015-ky4y2xjt 84 23 found find VBN cord-326015-ky4y2xjt 84 24 in in IN cord-326015-ky4y2xjt 84 25 later later JJ cord-326015-ky4y2xjt 84 26 ones one NNS cord-326015-ky4y2xjt 84 27 . . . cord-326015-ky4y2xjt 85 1 We -PRON- PRP cord-326015-ky4y2xjt 85 2 suggest suggest VBP cord-326015-ky4y2xjt 85 3 that that IN cord-326015-ky4y2xjt 85 4 such such JJ cord-326015-ky4y2xjt 85 5 di¡erential di¡erential JJ cord-326015-ky4y2xjt 85 6 ability ability NN cord-326015-ky4y2xjt 85 7 is be VBZ cord-326015-ky4y2xjt 85 8 achieved achieve VBN cord-326015-ky4y2xjt 85 9 through through IN cord-326015-ky4y2xjt 85 10 a a DT cord-326015-ky4y2xjt 85 11 combination combination NN cord-326015-ky4y2xjt 85 12 of of IN cord-326015-ky4y2xjt 85 13 two two CD cord-326015-ky4y2xjt 85 14 mechanisms mechanism NNS cord-326015-ky4y2xjt 85 15 : : : cord-326015-ky4y2xjt 85 16 The the DT cord-326015-ky4y2xjt 85 17 ¢rst ¢rst NN cord-326015-ky4y2xjt 85 18 envisages envisage VBZ cord-326015-ky4y2xjt 85 19 a a DT cord-326015-ky4y2xjt 85 20 direct direct JJ cord-326015-ky4y2xjt 85 21 interaction interaction NN cord-326015-ky4y2xjt 85 22 between between IN cord-326015-ky4y2xjt 85 23 residents resident NNS cord-326015-ky4y2xjt 85 24 and and CC cord-326015-ky4y2xjt 85 25 coat coat NN cord-326015-ky4y2xjt 85 26 components component NNS cord-326015-ky4y2xjt 85 27 forming form VBG cord-326015-ky4y2xjt 85 28 the the DT cord-326015-ky4y2xjt 85 29 RTC RTC NNP cord-326015-ky4y2xjt 85 30 . . . cord-326015-ky4y2xjt 86 1 This this DT cord-326015-ky4y2xjt 86 2 ensures ensure VBZ cord-326015-ky4y2xjt 86 3 and and CC cord-326015-ky4y2xjt 86 4 allows allow VBZ cord-326015-ky4y2xjt 86 5 for for IN cord-326015-ky4y2xjt 86 6 their -PRON- PRP$ cord-326015-ky4y2xjt 86 7 incorporation incorporation NN cord-326015-ky4y2xjt 86 8 . . . cord-326015-ky4y2xjt 87 1 The the DT cord-326015-ky4y2xjt 87 2 second second NN cord-326015-ky4y2xjt 87 3 envisages envisage VBZ cord-326015-ky4y2xjt 87 4 a a DT cord-326015-ky4y2xjt 87 5 mechanism mechanism NN cord-326015-ky4y2xjt 87 6 which which WDT cord-326015-ky4y2xjt 87 7 is be VBZ cord-326015-ky4y2xjt 87 8 milieu milieu NN cord-326015-ky4y2xjt 87 9 induced induce VBN cord-326015-ky4y2xjt 87 10 promoting promote VBG cord-326015-ky4y2xjt 87 11 incorporation incorporation NN cord-326015-ky4y2xjt 87 12 of of IN cord-326015-ky4y2xjt 87 13 residents resident NNS cord-326015-ky4y2xjt 87 14 into into IN cord-326015-ky4y2xjt 87 15 RTCs rtc NNS cord-326015-ky4y2xjt 87 16 . . . cord-326015-ky4y2xjt 88 1 Both both DT cord-326015-ky4y2xjt 88 2 mechanisms mechanism NNS cord-326015-ky4y2xjt 88 3 are be VBP cord-326015-ky4y2xjt 88 4 related relate VBN cord-326015-ky4y2xjt 88 5 to to IN cord-326015-ky4y2xjt 88 6 current current JJ cord-326015-ky4y2xjt 88 7 sorting sorting NN cord-326015-ky4y2xjt 88 8 models model NNS cord-326015-ky4y2xjt 88 9 for for IN cord-326015-ky4y2xjt 88 10 ER ER NNP cord-326015-ky4y2xjt 88 11 and and CC cord-326015-ky4y2xjt 88 12 Golgi Golgi NNP cord-326015-ky4y2xjt 88 13 residents resident NNS cord-326015-ky4y2xjt 88 14 and and CC cord-326015-ky4y2xjt 88 15 we -PRON- PRP cord-326015-ky4y2xjt 88 16 will will MD cord-326015-ky4y2xjt 88 17 discuss discuss VB cord-326015-ky4y2xjt 88 18 these these DT cord-326015-ky4y2xjt 88 19 below below RB cord-326015-ky4y2xjt 88 20 in in IN cord-326015-ky4y2xjt 88 21 the the DT cord-326015-ky4y2xjt 88 22 context context NN cord-326015-ky4y2xjt 88 23 of of IN cord-326015-ky4y2xjt 88 24 cisternal cisternal JJ cord-326015-ky4y2xjt 88 25 maturation maturation NN cord-326015-ky4y2xjt 88 26 . . . cord-326015-ky4y2xjt 89 1 The the DT cord-326015-ky4y2xjt 89 2 surprising surprising JJ cord-326015-ky4y2xjt 89 3 ¢nding ¢nding NN cord-326015-ky4y2xjt 90 1 that that IN cord-326015-ky4y2xjt 90 2 the the DT cord-326015-ky4y2xjt 90 3 membrane membrane NN cord-326015-ky4y2xjt 90 4 spanning span VBG cord-326015-ky4y2xjt 90 5 domain domain NN cord-326015-ky4y2xjt 90 6 ( ( -LRB- cord-326015-ky4y2xjt 90 7 MSD MSD NNP cord-326015-ky4y2xjt 90 8 ) ) -RRB- cord-326015-ky4y2xjt 90 9 of of IN cord-326015-ky4y2xjt 90 10 Golgi Golgi NNP cord-326015-ky4y2xjt 90 11 residents resident NNS cord-326015-ky4y2xjt 90 12 su¤ced su¤ced CD cord-326015-ky4y2xjt 90 13 to to TO cord-326015-ky4y2xjt 90 14 localise localise VB cord-326015-ky4y2xjt 90 15 reporter reporter NN cord-326015-ky4y2xjt 90 16 molecules molecule NNS cord-326015-ky4y2xjt 90 17 to to IN cord-326015-ky4y2xjt 90 18 the the DT cord-326015-ky4y2xjt 90 19 appropriate appropriate JJ cord-326015-ky4y2xjt 90 20 part part NN cord-326015-ky4y2xjt 90 21 of of IN cord-326015-ky4y2xjt 90 22 the the DT cord-326015-ky4y2xjt 90 23 pathway pathway NN cord-326015-ky4y2xjt 90 24 suggested suggest VBD cord-326015-ky4y2xjt 90 25 that that IN cord-326015-ky4y2xjt 90 26 this this DT cord-326015-ky4y2xjt 90 27 domain domain NN cord-326015-ky4y2xjt 90 28 harboured harbour VBD cord-326015-ky4y2xjt 90 29 important important JJ cord-326015-ky4y2xjt 90 30 sorting sort VBG cord-326015-ky4y2xjt 90 31 information information NN cord-326015-ky4y2xjt 90 32 ( ( -LRB- cord-326015-ky4y2xjt 90 33 for for IN cord-326015-ky4y2xjt 90 34 review review NN cord-326015-ky4y2xjt 90 35 , , , cord-326015-ky4y2xjt 90 36 see see VB cord-326015-ky4y2xjt 90 37 [ [ -LRB- cord-326015-ky4y2xjt 90 38 22 22 CD cord-326015-ky4y2xjt 90 39 ] ] -RRB- cord-326015-ky4y2xjt 90 40 ) ) -RRB- cord-326015-ky4y2xjt 90 41 . . . cord-326015-ky4y2xjt 91 1 Attention attention NN cord-326015-ky4y2xjt 91 2 was be VBD cord-326015-ky4y2xjt 91 3 focussed focusse VBN cord-326015-ky4y2xjt 91 4 on on IN cord-326015-ky4y2xjt 91 5 this this DT cord-326015-ky4y2xjt 91 6 domain domain NN cord-326015-ky4y2xjt 91 7 and and CC cord-326015-ky4y2xjt 91 8 di¡erent di¡erent NNP cord-326015-ky4y2xjt 91 9 models model NNS cord-326015-ky4y2xjt 91 10 were be VBD cord-326015-ky4y2xjt 91 11 put put VBN cord-326015-ky4y2xjt 91 12 forward forward RB cord-326015-ky4y2xjt 91 13 explaining explain VBG cord-326015-ky4y2xjt 91 14 how how WRB cord-326015-ky4y2xjt 91 15 an an DT cord-326015-ky4y2xjt 91 16 MSD MSD NNP cord-326015-ky4y2xjt 91 17 would would MD cord-326015-ky4y2xjt 91 18 mediate mediate VB cord-326015-ky4y2xjt 91 19 protein protein NN cord-326015-ky4y2xjt 91 20 sorting sorting NN cord-326015-ky4y2xjt 91 21 ( ( -LRB- cord-326015-ky4y2xjt 91 22 for for IN cord-326015-ky4y2xjt 91 23 review review NN cord-326015-ky4y2xjt 91 24 , , , cord-326015-ky4y2xjt 91 25 see see VB cord-326015-ky4y2xjt 91 26 [ [ -LRB- cord-326015-ky4y2xjt 91 27 23 23 CD cord-326015-ky4y2xjt 91 28 ] ] -RRB- cord-326015-ky4y2xjt 91 29 ) ) -RRB- cord-326015-ky4y2xjt 91 30 . . . cord-326015-ky4y2xjt 92 1 In in IN cord-326015-ky4y2xjt 92 2 one one CD cord-326015-ky4y2xjt 92 3 model model NN cord-326015-ky4y2xjt 92 4 , , , cord-326015-ky4y2xjt 92 5 Bretscher Bretscher NNP cord-326015-ky4y2xjt 92 6 and and CC cord-326015-ky4y2xjt 92 7 Munro Munro NNP cord-326015-ky4y2xjt 92 8 argue argue VBP cord-326015-ky4y2xjt 92 9 that that IN cord-326015-ky4y2xjt 92 10 membrane membrane NN cord-326015-ky4y2xjt 92 11 thickness thickness NN cord-326015-ky4y2xjt 92 12 determines determine VBZ cord-326015-ky4y2xjt 92 13 how how WRB cord-326015-ky4y2xjt 92 14 far far JJ cord-326015-ky4y2xjt 92 15 resident resident JJ cord-326015-ky4y2xjt 92 16 proteins protein NNS cord-326015-ky4y2xjt 92 17 would would MD cord-326015-ky4y2xjt 92 18 travel travel VB cord-326015-ky4y2xjt 92 19 into into IN cord-326015-ky4y2xjt 92 20 the the DT cord-326015-ky4y2xjt 92 21 pathway pathway NN cord-326015-ky4y2xjt 92 22 . . . cord-326015-ky4y2xjt 93 1 They -PRON- PRP cord-326015-ky4y2xjt 93 2 showed show VBD cord-326015-ky4y2xjt 93 3 that that IN cord-326015-ky4y2xjt 93 4 , , , cord-326015-ky4y2xjt 93 5 on on IN cord-326015-ky4y2xjt 93 6 average average JJ cord-326015-ky4y2xjt 93 7 , , , cord-326015-ky4y2xjt 93 8 resident resident NN cord-326015-ky4y2xjt 93 9 proteins protein NNS cord-326015-ky4y2xjt 93 10 of of IN cord-326015-ky4y2xjt 93 11 the the DT cord-326015-ky4y2xjt 93 12 exocytic exocytic JJ cord-326015-ky4y2xjt 93 13 pathway pathway NN cord-326015-ky4y2xjt 93 14 have have VBP cord-326015-ky4y2xjt 93 15 signi¢cantly signi¢cantly RB cord-326015-ky4y2xjt 93 16 shorter short JJR cord-326015-ky4y2xjt 93 17 membrane membrane NN cord-326015-ky4y2xjt 93 18 spanning span VBG cord-326015-ky4y2xjt 93 19 domains domain NNS cord-326015-ky4y2xjt 93 20 compared compare VBN cord-326015-ky4y2xjt 93 21 to to IN cord-326015-ky4y2xjt 93 22 those those DT cord-326015-ky4y2xjt 93 23 found find VBN cord-326015-ky4y2xjt 93 24 on on IN cord-326015-ky4y2xjt 93 25 the the DT cord-326015-ky4y2xjt 93 26 plasma plasma NN cord-326015-ky4y2xjt 93 27 membrane membrane NN cord-326015-ky4y2xjt 93 28 [ [ -LRB- cord-326015-ky4y2xjt 93 29 24 24 CD cord-326015-ky4y2xjt 93 30 ] ] -RRB- cord-326015-ky4y2xjt 93 31 . . . cord-326015-ky4y2xjt 94 1 Furthermore furthermore RB cord-326015-ky4y2xjt 94 2 , , , cord-326015-ky4y2xjt 94 3 Munro Munro NNP cord-326015-ky4y2xjt 94 4 [ [ -LRB- cord-326015-ky4y2xjt 94 5 25 25 CD cord-326015-ky4y2xjt 94 6 , , , cord-326015-ky4y2xjt 94 7 26 26 CD cord-326015-ky4y2xjt 94 8 ] ] -RRB- cord-326015-ky4y2xjt 94 9 showed show VBD cord-326015-ky4y2xjt 94 10 that that IN cord-326015-ky4y2xjt 94 11 the the DT cord-326015-ky4y2xjt 94 12 amino amino NN cord-326015-ky4y2xjt 94 13 acid acid NN cord-326015-ky4y2xjt 94 14 composition composition NN cord-326015-ky4y2xjt 94 15 of of IN cord-326015-ky4y2xjt 94 16 the the DT cord-326015-ky4y2xjt 94 17 MSD MSD NNP cord-326015-ky4y2xjt 94 18 of of IN cord-326015-ky4y2xjt 94 19 Golgi Golgi NNP cord-326015-ky4y2xjt 94 20 residents resident NNS cord-326015-ky4y2xjt 94 21 could could MD cord-326015-ky4y2xjt 94 22 be be VB cord-326015-ky4y2xjt 94 23 altered alter VBN cord-326015-ky4y2xjt 94 24 to to IN cord-326015-ky4y2xjt 94 25 poly poly NNP cord-326015-ky4y2xjt 94 26 - - HYPH cord-326015-ky4y2xjt 94 27 leucins leucin NNS cord-326015-ky4y2xjt 94 28 without without IN cord-326015-ky4y2xjt 94 29 changing change VBG cord-326015-ky4y2xjt 94 30 their -PRON- PRP$ cord-326015-ky4y2xjt 94 31 intracellular intracellular JJ cord-326015-ky4y2xjt 94 32 distribution distribution NN cord-326015-ky4y2xjt 94 33 but but CC cord-326015-ky4y2xjt 94 34 that that IN cord-326015-ky4y2xjt 94 35 extending extend VBG cord-326015-ky4y2xjt 94 36 their -PRON- PRP$ cord-326015-ky4y2xjt 94 37 lengths length NNS cord-326015-ky4y2xjt 94 38 resulted result VBN cord-326015-ky4y2xjt 94 39 in in IN cord-326015-ky4y2xjt 94 40 plasma plasma NN cord-326015-ky4y2xjt 94 41 membrane membrane NN cord-326015-ky4y2xjt 94 42 localisation localisation NN cord-326015-ky4y2xjt 94 43 . . . cord-326015-ky4y2xjt 95 1 This this DT cord-326015-ky4y2xjt 95 2 suggested suggest VBD cord-326015-ky4y2xjt 95 3 that that DT cord-326015-ky4y2xjt 95 4 length length NN cord-326015-ky4y2xjt 95 5 rather rather RB cord-326015-ky4y2xjt 95 6 than than IN cord-326015-ky4y2xjt 95 7 amino amino NN cord-326015-ky4y2xjt 95 8 acid acid NN cord-326015-ky4y2xjt 95 9 composition composition NN cord-326015-ky4y2xjt 95 10 is be VBZ cord-326015-ky4y2xjt 95 11 important important JJ cord-326015-ky4y2xjt 95 12 . . . cord-326015-ky4y2xjt 96 1 The the DT cord-326015-ky4y2xjt 96 2 notion notion NN cord-326015-ky4y2xjt 96 3 that that IN cord-326015-ky4y2xjt 96 4 polar polar JJ cord-326015-ky4y2xjt 96 5 residues residue NNS cord-326015-ky4y2xjt 96 6 were be VBD cord-326015-ky4y2xjt 96 7 more more RBR cord-326015-ky4y2xjt 96 8 common common JJ cord-326015-ky4y2xjt 96 9 in in IN cord-326015-ky4y2xjt 96 10 MSDs msd NNS cord-326015-ky4y2xjt 96 11 of of IN cord-326015-ky4y2xjt 96 12 Golgi Golgi NNP cord-326015-ky4y2xjt 96 13 residents resident NNS cord-326015-ky4y2xjt 96 14 further further RB cord-326015-ky4y2xjt 96 15 argued argue VBD cord-326015-ky4y2xjt 96 16 that that IN cord-326015-ky4y2xjt 96 17 their -PRON- PRP$ cord-326015-ky4y2xjt 96 18 hydrophobic hydrophobic JJ cord-326015-ky4y2xjt 96 19 stretches stretch NNS cord-326015-ky4y2xjt 96 20 were be VBD cord-326015-ky4y2xjt 96 21 shorter short JJR cord-326015-ky4y2xjt 96 22 than than IN cord-326015-ky4y2xjt 96 23 those those DT cord-326015-ky4y2xjt 96 24 of of IN cord-326015-ky4y2xjt 96 25 plasma plasma NN cord-326015-ky4y2xjt 96 26 membrane membrane NN cord-326015-ky4y2xjt 96 27 proteins protein NNS cord-326015-ky4y2xjt 96 28 . . . cord-326015-ky4y2xjt 97 1 A a DT cord-326015-ky4y2xjt 97 2 model model NN cord-326015-ky4y2xjt 97 3 was be VBD cord-326015-ky4y2xjt 97 4 proposed propose VBN cord-326015-ky4y2xjt 97 5 based base VBN cord-326015-ky4y2xjt 97 6 on on IN cord-326015-ky4y2xjt 97 7 a a DT cord-326015-ky4y2xjt 97 8 gradual gradual JJ cord-326015-ky4y2xjt 97 9 increase increase NN cord-326015-ky4y2xjt 97 10 of of IN cord-326015-ky4y2xjt 97 11 membrane membrane NN cord-326015-ky4y2xjt 97 12 thickness thickness NN cord-326015-ky4y2xjt 97 13 from from IN cord-326015-ky4y2xjt 97 14 the the DT cord-326015-ky4y2xjt 97 15 ER ER NNP cord-326015-ky4y2xjt 97 16 towards towards IN cord-326015-ky4y2xjt 97 17 the the DT cord-326015-ky4y2xjt 97 18 plasma plasma NN cord-326015-ky4y2xjt 97 19 membrane membrane NN cord-326015-ky4y2xjt 97 20 [ [ -LRB- cord-326015-ky4y2xjt 97 21 24 24 CD cord-326015-ky4y2xjt 97 22 ] ] -RRB- cord-326015-ky4y2xjt 97 23 . . . cord-326015-ky4y2xjt 98 1 Such such PDT cord-326015-ky4y2xjt 98 2 a a DT cord-326015-ky4y2xjt 98 3 membrane membrane NN cord-326015-ky4y2xjt 98 4 thickness thickness NN cord-326015-ky4y2xjt 98 5 gradient gradient NN cord-326015-ky4y2xjt 98 6 would would MD cord-326015-ky4y2xjt 98 7 be be VB cord-326015-ky4y2xjt 98 8 due due JJ cord-326015-ky4y2xjt 98 9 to to IN cord-326015-ky4y2xjt 98 10 a a DT cord-326015-ky4y2xjt 98 11 gradual gradual JJ cord-326015-ky4y2xjt 98 12 increase increase NN cord-326015-ky4y2xjt 98 13 in in IN cord-326015-ky4y2xjt 98 14 cholesterol cholesterol NN cord-326015-ky4y2xjt 98 15 and and CC cord-326015-ky4y2xjt 98 16 sphingomyelin sphingomyelin NN cord-326015-ky4y2xjt 98 17 concentration concentration NN cord-326015-ky4y2xjt 98 18 . . . cord-326015-ky4y2xjt 99 1 Indeed indeed RB cord-326015-ky4y2xjt 99 2 , , , cord-326015-ky4y2xjt 99 3 early early JJ cord-326015-ky4y2xjt 99 4 work work NN cord-326015-ky4y2xjt 99 5 suggested suggest VBD cord-326015-ky4y2xjt 99 6 the the DT cord-326015-ky4y2xjt 99 7 presence presence NN cord-326015-ky4y2xjt 99 8 of of IN cord-326015-ky4y2xjt 99 9 a a DT cord-326015-ky4y2xjt 99 10 cholesterol cholesterol NN cord-326015-ky4y2xjt 99 11 gradient gradient NN cord-326015-ky4y2xjt 99 12 across across IN cord-326015-ky4y2xjt 99 13 the the DT cord-326015-ky4y2xjt 99 14 exocytic exocytic JJ cord-326015-ky4y2xjt 99 15 pathway pathway NN cord-326015-ky4y2xjt 99 16 [ [ -LRB- cord-326015-ky4y2xjt 99 17 27 27 CD cord-326015-ky4y2xjt 99 18 ] ] -RRB- cord-326015-ky4y2xjt 99 19 . . . cord-326015-ky4y2xjt 100 1 In in IN cord-326015-ky4y2xjt 100 2 a a DT cord-326015-ky4y2xjt 100 3 vesicular vesicular JJ cord-326015-ky4y2xjt 100 4 transport transport NN cord-326015-ky4y2xjt 100 5 model model NN cord-326015-ky4y2xjt 100 6 , , , cord-326015-ky4y2xjt 100 7 this this DT cord-326015-ky4y2xjt 100 8 gradient gradient NN cord-326015-ky4y2xjt 100 9 would would MD cord-326015-ky4y2xjt 100 10 be be VB cord-326015-ky4y2xjt 100 11 maintained maintain VBN cord-326015-ky4y2xjt 100 12 by by IN cord-326015-ky4y2xjt 100 13 selective selective JJ cord-326015-ky4y2xjt 100 14 sampling sampling NN cord-326015-ky4y2xjt 100 15 of of IN cord-326015-ky4y2xjt 100 16 cholesterol cholesterol NN cord-326015-ky4y2xjt 100 17 into into IN cord-326015-ky4y2xjt 100 18 forward forward JJ cord-326015-ky4y2xjt 100 19 transport transport NN cord-326015-ky4y2xjt 100 20 vesicles vesicle NNS cord-326015-ky4y2xjt 100 21 but but CC cord-326015-ky4y2xjt 100 22 not not RB cord-326015-ky4y2xjt 100 23 into into IN cord-326015-ky4y2xjt 100 24 RTCs rtc NNS cord-326015-ky4y2xjt 100 25 . . . cord-326015-ky4y2xjt 101 1 In in IN cord-326015-ky4y2xjt 101 2 the the DT cord-326015-ky4y2xjt 101 3 cisternal cisternal JJ cord-326015-ky4y2xjt 101 4 maturation maturation NN cord-326015-ky4y2xjt 101 5 model model NN cord-326015-ky4y2xjt 101 6 , , , cord-326015-ky4y2xjt 101 7 the the DT cord-326015-ky4y2xjt 101 8 gradient gradient NN cord-326015-ky4y2xjt 101 9 would would MD cord-326015-ky4y2xjt 101 10 be be VB cord-326015-ky4y2xjt 101 11 maintained maintain VBN cord-326015-ky4y2xjt 101 12 by by IN cord-326015-ky4y2xjt 101 13 exclusion exclusion NN cord-326015-ky4y2xjt 101 14 of of IN cord-326015-ky4y2xjt 101 15 cholesterol cholesterol NN cord-326015-ky4y2xjt 101 16 and and CC cord-326015-ky4y2xjt 101 17 sphingomyelin sphingomyelin NN cord-326015-ky4y2xjt 101 18 from from IN cord-326015-ky4y2xjt 101 19 budding bud VBG cord-326015-ky4y2xjt 101 20 RTCs rtc NNS cord-326015-ky4y2xjt 101 21 . . . cord-326015-ky4y2xjt 102 1 However however RB cord-326015-ky4y2xjt 102 2 , , , cord-326015-ky4y2xjt 102 3 in in IN cord-326015-ky4y2xjt 102 4 the the DT cord-326015-ky4y2xjt 102 5 context context NN cord-326015-ky4y2xjt 102 6 of of IN cord-326015-ky4y2xjt 102 7 the the DT cord-326015-ky4y2xjt 102 8 latter latter JJ cord-326015-ky4y2xjt 102 9 model model NN cord-326015-ky4y2xjt 102 10 , , , cord-326015-ky4y2xjt 102 11 sorting sort VBG cord-326015-ky4y2xjt 102 12 through through IN cord-326015-ky4y2xjt 102 13 membrane membrane NN cord-326015-ky4y2xjt 102 14 thickness thickness NN cord-326015-ky4y2xjt 102 15 would would MD cord-326015-ky4y2xjt 102 16 not not RB cord-326015-ky4y2xjt 102 17 prevent prevent VB cord-326015-ky4y2xjt 102 18 residents resident NNS cord-326015-ky4y2xjt 102 19 to to TO cord-326015-ky4y2xjt 102 20 enter enter VB cord-326015-ky4y2xjt 102 21 RTCs rtc NNS cord-326015-ky4y2xjt 102 22 prematurely prematurely RB cord-326015-ky4y2xjt 102 23 , , , cord-326015-ky4y2xjt 102 24 and and CC cord-326015-ky4y2xjt 102 25 could could MD cord-326015-ky4y2xjt 102 26 therefore therefore RB cord-326015-ky4y2xjt 102 27 not not RB cord-326015-ky4y2xjt 102 28 explain explain VB cord-326015-ky4y2xjt 102 29 observed observed JJ cord-326015-ky4y2xjt 102 30 gradients gradient NNS cord-326015-ky4y2xjt 102 31 of of IN cord-326015-ky4y2xjt 102 32 residents resident NNS cord-326015-ky4y2xjt 102 33 in in IN cord-326015-ky4y2xjt 102 34 later later JJ cord-326015-ky4y2xjt 102 35 parts part NNS cord-326015-ky4y2xjt 102 36 of of IN cord-326015-ky4y2xjt 102 37 the the DT cord-326015-ky4y2xjt 102 38 pathway pathway NN cord-326015-ky4y2xjt 102 39 . . . cord-326015-ky4y2xjt 103 1 So so RB cord-326015-ky4y2xjt 103 2 far far RB cord-326015-ky4y2xjt 103 3 , , , cord-326015-ky4y2xjt 103 4 no no DT cord-326015-ky4y2xjt 103 5 correlation correlation NN cord-326015-ky4y2xjt 103 6 has have VBZ cord-326015-ky4y2xjt 103 7 been be VBN cord-326015-ky4y2xjt 103 8 observed observe VBN cord-326015-ky4y2xjt 103 9 between between IN cord-326015-ky4y2xjt 103 10 the the DT cord-326015-ky4y2xjt 103 11 length length NN cord-326015-ky4y2xjt 103 12 of of IN cord-326015-ky4y2xjt 103 13 MSDs msd NNS cord-326015-ky4y2xjt 103 14 of of IN cord-326015-ky4y2xjt 103 15 Golgi Golgi NNP cord-326015-ky4y2xjt 103 16 resident resident NN cord-326015-ky4y2xjt 103 17 glycosylation glycosylation NN cord-326015-ky4y2xjt 103 18 enzymes enzyme NNS cord-326015-ky4y2xjt 103 19 and and CC cord-326015-ky4y2xjt 103 20 their -PRON- PRP$ cord-326015-ky4y2xjt 103 21 corresponding correspond VBG cord-326015-ky4y2xjt 103 22 intra intra JJ cord-326015-ky4y2xjt 103 23 Golgi Golgi NNP cord-326015-ky4y2xjt 103 24 localisation localisation NN cord-326015-ky4y2xjt 103 25 ( ( -LRB- cord-326015-ky4y2xjt 103 26 for for IN cord-326015-ky4y2xjt 103 27 discussion discussion NN cord-326015-ky4y2xjt 103 28 , , , cord-326015-ky4y2xjt 103 29 see see VB cord-326015-ky4y2xjt 103 30 [ [ -LRB- cord-326015-ky4y2xjt 103 31 28 28 CD cord-326015-ky4y2xjt 103 32 ] ] -RRB- cord-326015-ky4y2xjt 103 33 ) ) -RRB- cord-326015-ky4y2xjt 103 34 . . . cord-326015-ky4y2xjt 104 1 Furthermore furthermore RB cord-326015-ky4y2xjt 104 2 , , , cord-326015-ky4y2xjt 104 3 upon upon IN cord-326015-ky4y2xjt 104 4 shortening shorten VBG cord-326015-ky4y2xjt 104 5 the the DT cord-326015-ky4y2xjt 104 6 cytoplasmic cytoplasmic JJ cord-326015-ky4y2xjt 104 7 domain domain NN cord-326015-ky4y2xjt 104 8 of of IN cord-326015-ky4y2xjt 104 9 GalT GalT NNP cord-326015-ky4y2xjt 104 10 , , , cord-326015-ky4y2xjt 104 11 this this DT cord-326015-ky4y2xjt 104 12 molecule molecule NN cord-326015-ky4y2xjt 104 13 is be VBZ cord-326015-ky4y2xjt 104 14 subsequently subsequently RB cord-326015-ky4y2xjt 104 15 found find VBN cord-326015-ky4y2xjt 104 16 on on IN cord-326015-ky4y2xjt 104 17 the the DT cord-326015-ky4y2xjt 104 18 plasma plasma NN cord-326015-ky4y2xjt 104 19 membrane membrane NN cord-326015-ky4y2xjt 104 20 showing show VBG cord-326015-ky4y2xjt 104 21 that that IN cord-326015-ky4y2xjt 104 22 its -PRON- PRP$ cord-326015-ky4y2xjt 104 23 MSD MSD NNP cord-326015-ky4y2xjt 104 24 is be VBZ cord-326015-ky4y2xjt 104 25 compatible compatible JJ cord-326015-ky4y2xjt 104 26 with with IN cord-326015-ky4y2xjt 104 27 this this DT cord-326015-ky4y2xjt 104 28 membrane membrane NN cord-326015-ky4y2xjt 104 29 [ [ -LRB- cord-326015-ky4y2xjt 104 30 29 29 CD cord-326015-ky4y2xjt 104 31 ] ] -RRB- cord-326015-ky4y2xjt 104 32 . . . cord-326015-ky4y2xjt 105 1 Also also RB cord-326015-ky4y2xjt 105 2 , , , cord-326015-ky4y2xjt 105 3 the the DT cord-326015-ky4y2xjt 105 4 high high JJ cord-326015-ky4y2xjt 105 5 degree degree NN cord-326015-ky4y2xjt 105 6 of of IN cord-326015-ky4y2xjt 105 7 conserved conserved JJ cord-326015-ky4y2xjt 105 8 amino amino NN cord-326015-ky4y2xjt 105 9 acids acid NNS cord-326015-ky4y2xjt 105 10 observed observe VBN cord-326015-ky4y2xjt 105 11 in in IN cord-326015-ky4y2xjt 105 12 MSDs msd NNS cord-326015-ky4y2xjt 105 13 of of IN cord-326015-ky4y2xjt 105 14 Golgi Golgi NNP cord-326015-ky4y2xjt 105 15 residents resident NNS cord-326015-ky4y2xjt 105 16 would would MD cord-326015-ky4y2xjt 105 17 not not RB cord-326015-ky4y2xjt 105 18 be be VB cord-326015-ky4y2xjt 105 19 predicted predict VBN cord-326015-ky4y2xjt 105 20 if if IN cord-326015-ky4y2xjt 105 21 they -PRON- PRP cord-326015-ky4y2xjt 105 22 merely merely RB cord-326015-ky4y2xjt 105 23 serve serve VBP cord-326015-ky4y2xjt 105 24 as as IN cord-326015-ky4y2xjt 105 25 membrane membrane NN cord-326015-ky4y2xjt 105 26 anchors anchor NNS cord-326015-ky4y2xjt 105 27 with with IN cord-326015-ky4y2xjt 105 28 a a DT cord-326015-ky4y2xjt 105 29 speci¢ed speci¢ed CD cord-326015-ky4y2xjt 105 30 length length NN cord-326015-ky4y2xjt 105 31 . . . cord-326015-ky4y2xjt 106 1 Rather rather RB cord-326015-ky4y2xjt 106 2 , , , cord-326015-ky4y2xjt 106 3 as as IN cord-326015-ky4y2xjt 106 4 proposed propose VBN cord-326015-ky4y2xjt 106 5 earlier early RBR cord-326015-ky4y2xjt 106 6 , , , cord-326015-ky4y2xjt 106 7 MSDs msds VB cord-326015-ky4y2xjt 106 8 aid aid NN cord-326015-ky4y2xjt 106 9 in in IN cord-326015-ky4y2xjt 106 10 the the DT cord-326015-ky4y2xjt 106 11 formation formation NN cord-326015-ky4y2xjt 106 12 of of IN cord-326015-ky4y2xjt 106 13 oligomeric oligomeric JJ cord-326015-ky4y2xjt 106 14 protein protein NN cord-326015-ky4y2xjt 106 15 complexes complex NNS cord-326015-ky4y2xjt 106 16 [ [ -LRB- cord-326015-ky4y2xjt 106 17 29 29 CD cord-326015-ky4y2xjt 106 18 , , , cord-326015-ky4y2xjt 106 19 30 30 CD cord-326015-ky4y2xjt 106 20 ] ] -RRB- cord-326015-ky4y2xjt 106 21 . . . cord-326015-ky4y2xjt 107 1 This this DT cord-326015-ky4y2xjt 107 2 could could MD cord-326015-ky4y2xjt 107 3 be be VB cord-326015-ky4y2xjt 107 4 possible possible JJ cord-326015-ky4y2xjt 107 5 either either CC cord-326015-ky4y2xjt 107 6 through through IN cord-326015-ky4y2xjt 107 7 a a DT cord-326015-ky4y2xjt 107 8 direct direct JJ cord-326015-ky4y2xjt 107 9 interaction interaction NN cord-326015-ky4y2xjt 107 10 with with IN cord-326015-ky4y2xjt 107 11 spe spe NNP cord-326015-ky4y2xjt 107 12 - - HYPH cord-326015-ky4y2xjt 107 13 ci¢c ci¢c JJ cord-326015-ky4y2xjt 107 14 lipids lipid NNS cord-326015-ky4y2xjt 107 15 or or CC cord-326015-ky4y2xjt 107 16 lipid lipid NN cord-326015-ky4y2xjt 107 17 domains domain NNS cord-326015-ky4y2xjt 107 18 or or CC cord-326015-ky4y2xjt 107 19 through through IN cord-326015-ky4y2xjt 107 20 protein protein NN cord-326015-ky4y2xjt 107 21 - - HYPH cord-326015-ky4y2xjt 107 22 protein protein NN cord-326015-ky4y2xjt 107 23 interaction interaction NN cord-326015-ky4y2xjt 107 24 . . . cord-326015-ky4y2xjt 108 1 Arguments argument NNS cord-326015-ky4y2xjt 108 2 in in IN cord-326015-ky4y2xjt 108 3 favour favour NN cord-326015-ky4y2xjt 108 4 of of IN cord-326015-ky4y2xjt 108 5 such such PDT cord-326015-ky4y2xjt 108 6 a a DT cord-326015-ky4y2xjt 108 7 scenario scenario NN cord-326015-ky4y2xjt 108 8 come come VBN cord-326015-ky4y2xjt 108 9 from from IN cord-326015-ky4y2xjt 108 10 the the DT cord-326015-ky4y2xjt 108 11 notion notion NN cord-326015-ky4y2xjt 108 12 that that IN cord-326015-ky4y2xjt 108 13 Golgi Golgi NNP cord-326015-ky4y2xjt 108 14 residents resident NNS cord-326015-ky4y2xjt 108 15 may may MD cord-326015-ky4y2xjt 108 16 be be VB cord-326015-ky4y2xjt 108 17 isolated isolate VBN cord-326015-ky4y2xjt 108 18 as as IN cord-326015-ky4y2xjt 108 19 detergent detergent NN cord-326015-ky4y2xjt 108 20 insoluble insoluble JJ cord-326015-ky4y2xjt 108 21 complexes complex NNS cord-326015-ky4y2xjt 108 22 , , , cord-326015-ky4y2xjt 108 23 in in IN cord-326015-ky4y2xjt 108 24 vitro vitro FW cord-326015-ky4y2xjt 108 25 ( ( -LRB- cord-326015-ky4y2xjt 108 26 see see VB cord-326015-ky4y2xjt 108 27 below below RB cord-326015-ky4y2xjt 108 28 ) ) -RRB- cord-326015-ky4y2xjt 108 29 . . . cord-326015-ky4y2xjt 109 1 However however RB cord-326015-ky4y2xjt 109 2 , , , cord-326015-ky4y2xjt 109 3 such such JJ cord-326015-ky4y2xjt 109 4 complexes complex NNS cord-326015-ky4y2xjt 109 5 do do VBP cord-326015-ky4y2xjt 109 6 not not RB cord-326015-ky4y2xjt 109 7 £ £ VB cord-326015-ky4y2xjt 109 8 oat oat NN cord-326015-ky4y2xjt 109 9 when when WRB cord-326015-ky4y2xjt 109 10 subjected subject VBN cord-326015-ky4y2xjt 109 11 to to TO cord-326015-ky4y2xjt 109 12 gradient gradient VB cord-326015-ky4y2xjt 109 13 centrifugation centrifugation NN cord-326015-ky4y2xjt 109 14 . . . cord-326015-ky4y2xjt 110 1 Rather rather RB cord-326015-ky4y2xjt 110 2 , , , cord-326015-ky4y2xjt 110 3 they -PRON- PRP cord-326015-ky4y2xjt 110 4 are be VBP cord-326015-ky4y2xjt 110 5 readily readily RB cord-326015-ky4y2xjt 110 6 sedimentable sedimentable JJ cord-326015-ky4y2xjt 110 7 suggestive suggestive JJ cord-326015-ky4y2xjt 110 8 of of IN cord-326015-ky4y2xjt 110 9 complexes complex NNS cord-326015-ky4y2xjt 110 10 with with IN cord-326015-ky4y2xjt 110 11 a a DT cord-326015-ky4y2xjt 110 12 low low JJ cord-326015-ky4y2xjt 110 13 ratio ratio NN cord-326015-ky4y2xjt 110 14 of of IN cord-326015-ky4y2xjt 110 15 lipid lipid NN cord-326015-ky4y2xjt 110 16 to to IN cord-326015-ky4y2xjt 110 17 protein protein NN cord-326015-ky4y2xjt 110 18 held hold VBN cord-326015-ky4y2xjt 110 19 together together RB cord-326015-ky4y2xjt 110 20 by by IN cord-326015-ky4y2xjt 110 21 protein protein NN cord-326015-ky4y2xjt 110 22 - - HYPH cord-326015-ky4y2xjt 110 23 protein protein NN cord-326015-ky4y2xjt 110 24 interactions interaction NNS cord-326015-ky4y2xjt 110 25 . . . cord-326015-ky4y2xjt 111 1 That that IN cord-326015-ky4y2xjt 111 2 Golgi Golgi NNP cord-326015-ky4y2xjt 111 3 residents resident NNS cord-326015-ky4y2xjt 111 4 are be VBP cord-326015-ky4y2xjt 111 5 capable capable JJ cord-326015-ky4y2xjt 111 6 of of IN cord-326015-ky4y2xjt 111 7 mediating mediate VBG cord-326015-ky4y2xjt 111 8 direct direct JJ cord-326015-ky4y2xjt 111 9 protein protein NN cord-326015-ky4y2xjt 111 10 - - HYPH cord-326015-ky4y2xjt 111 11 protein protein NN cord-326015-ky4y2xjt 111 12 interaction interaction NN cord-326015-ky4y2xjt 111 13 comes come VBZ cord-326015-ky4y2xjt 111 14 from from IN cord-326015-ky4y2xjt 111 15 several several JJ cord-326015-ky4y2xjt 111 16 lines line NNS cord-326015-ky4y2xjt 111 17 of of IN cord-326015-ky4y2xjt 111 18 evidence evidence NN cord-326015-ky4y2xjt 111 19 . . . cord-326015-ky4y2xjt 112 1 First first RB cord-326015-ky4y2xjt 112 2 , , , cord-326015-ky4y2xjt 112 3 an an DT cord-326015-ky4y2xjt 112 4 MSD msd NN cord-326015-ky4y2xjt 112 5 of of IN cord-326015-ky4y2xjt 112 6 the the DT cord-326015-ky4y2xjt 112 7 cis cis NNP cord-326015-ky4y2xjt 112 8 Golgi Golgi NNP cord-326015-ky4y2xjt 112 9 resident resident NN cord-326015-ky4y2xjt 112 10 M M NNP cord-326015-ky4y2xjt 112 11 protein protein NN cord-326015-ky4y2xjt 112 12 of of IN cord-326015-ky4y2xjt 112 13 avian avian JJ cord-326015-ky4y2xjt 112 14 coronavirus coronavirus NN cord-326015-ky4y2xjt 112 15 infectious infectious JJ cord-326015-ky4y2xjt 112 16 bronchitis bronchitis NN cord-326015-ky4y2xjt 112 17 virus virus NN cord-326015-ky4y2xjt 112 18 has have VBZ cord-326015-ky4y2xjt 112 19 been be VBN cord-326015-ky4y2xjt 112 20 shown show VBN cord-326015-ky4y2xjt 112 21 to to TO cord-326015-ky4y2xjt 112 22 directly directly RB cord-326015-ky4y2xjt 112 23 promote promote VB cord-326015-ky4y2xjt 112 24 oligomerisation oligomerisation NN cord-326015-ky4y2xjt 112 25 as as RB cord-326015-ky4y2xjt 112 26 well well RB cord-326015-ky4y2xjt 112 27 as as IN cord-326015-ky4y2xjt 112 28 localisation localisation NN cord-326015-ky4y2xjt 112 29 [ [ -LRB- cord-326015-ky4y2xjt 112 30 31 31 CD cord-326015-ky4y2xjt 112 31 , , , cord-326015-ky4y2xjt 112 32 32 32 CD cord-326015-ky4y2xjt 112 33 ] ] -RRB- cord-326015-ky4y2xjt 112 34 . . . cord-326015-ky4y2xjt 113 1 This this DT cord-326015-ky4y2xjt 113 2 domain domain NN cord-326015-ky4y2xjt 113 3 su¤ces su¤ce VBZ cord-326015-ky4y2xjt 113 4 to to TO cord-326015-ky4y2xjt 113 5 localise localise VB cord-326015-ky4y2xjt 113 6 the the DT cord-326015-ky4y2xjt 113 7 G g NN cord-326015-ky4y2xjt 113 8 protein protein NN cord-326015-ky4y2xjt 113 9 of of IN cord-326015-ky4y2xjt 113 10 vesicular vesicular JJ cord-326015-ky4y2xjt 113 11 stomatitis stomatitis NN cord-326015-ky4y2xjt 113 12 virus virus NN cord-326015-ky4y2xjt 113 13 to to IN cord-326015-ky4y2xjt 113 14 the the DT cord-326015-ky4y2xjt 113 15 cis cis NNP cord-326015-ky4y2xjt 113 16 Golgi Golgi NNP cord-326015-ky4y2xjt 113 17 when when WRB cord-326015-ky4y2xjt 113 18 expressed express VBD cord-326015-ky4y2xjt 113 19 as as IN cord-326015-ky4y2xjt 113 20 a a DT cord-326015-ky4y2xjt 113 21 hybrid hybrid JJ cord-326015-ky4y2xjt 113 22 protein protein NN cord-326015-ky4y2xjt 113 23 . . . cord-326015-ky4y2xjt 114 1 When when WRB cord-326015-ky4y2xjt 114 2 polar polar JJ cord-326015-ky4y2xjt 114 3 residues residue NNS cord-326015-ky4y2xjt 114 4 facing face VBG cord-326015-ky4y2xjt 114 5 one one CD cord-326015-ky4y2xjt 114 6 side side NN cord-326015-ky4y2xjt 114 7 of of IN cord-326015-ky4y2xjt 114 8 the the DT cord-326015-ky4y2xjt 114 9 putative putative JJ cord-326015-ky4y2xjt 114 10 K K NNP cord-326015-ky4y2xjt 114 11 - - HYPH cord-326015-ky4y2xjt 114 12 helix helix NNP cord-326015-ky4y2xjt 114 13 were be VBD cord-326015-ky4y2xjt 114 14 mutated mutate VBN cord-326015-ky4y2xjt 114 15 , , , cord-326015-ky4y2xjt 114 16 it -PRON- PRP cord-326015-ky4y2xjt 114 17 resulted result VBD cord-326015-ky4y2xjt 114 18 not not RB cord-326015-ky4y2xjt 114 19 only only RB cord-326015-ky4y2xjt 114 20 in in IN cord-326015-ky4y2xjt 114 21 a a DT cord-326015-ky4y2xjt 114 22 loss loss NN cord-326015-ky4y2xjt 114 23 of of IN cord-326015-ky4y2xjt 114 24 intracellular intracellular JJ cord-326015-ky4y2xjt 114 25 localisation localisation NN cord-326015-ky4y2xjt 114 26 but but CC cord-326015-ky4y2xjt 114 27 also also RB cord-326015-ky4y2xjt 114 28 in in IN cord-326015-ky4y2xjt 114 29 a a DT cord-326015-ky4y2xjt 114 30 marked marked JJ cord-326015-ky4y2xjt 114 31 decrease decrease NN cord-326015-ky4y2xjt 114 32 in in IN cord-326015-ky4y2xjt 114 33 oligomeric oligomeric JJ cord-326015-ky4y2xjt 114 34 properties property NNS cord-326015-ky4y2xjt 114 35 of of IN cord-326015-ky4y2xjt 114 36 the the DT cord-326015-ky4y2xjt 114 37 mutated mutate VBN cord-326015-ky4y2xjt 114 38 hybrid hybrid JJ cord-326015-ky4y2xjt 114 39 protein protein NN cord-326015-ky4y2xjt 114 40 . . . cord-326015-ky4y2xjt 115 1 This this DT cord-326015-ky4y2xjt 115 2 showed show VBD cord-326015-ky4y2xjt 115 3 , , , cord-326015-ky4y2xjt 115 4 for for IN cord-326015-ky4y2xjt 115 5 the the DT cord-326015-ky4y2xjt 115 6 ¢rst ¢rst CD cord-326015-ky4y2xjt 115 7 time time NN cord-326015-ky4y2xjt 115 8 , , , cord-326015-ky4y2xjt 115 9 a a DT cord-326015-ky4y2xjt 115 10 direct direct JJ cord-326015-ky4y2xjt 115 11 role role NN cord-326015-ky4y2xjt 115 12 of of IN cord-326015-ky4y2xjt 115 13 MSDs msd NNS cord-326015-ky4y2xjt 115 14 in in IN cord-326015-ky4y2xjt 115 15 oligomerisation oligomerisation NN cord-326015-ky4y2xjt 115 16 of of IN cord-326015-ky4y2xjt 115 17 Golgi Golgi NNP cord-326015-ky4y2xjt 115 18 residents resident NNS cord-326015-ky4y2xjt 115 19 and and CC cord-326015-ky4y2xjt 115 20 that that IN cord-326015-ky4y2xjt 115 21 loss loss NN cord-326015-ky4y2xjt 115 22 of of IN cord-326015-ky4y2xjt 115 23 this this DT cord-326015-ky4y2xjt 115 24 property property NN cord-326015-ky4y2xjt 115 25 leads lead VBZ cord-326015-ky4y2xjt 115 26 to to IN cord-326015-ky4y2xjt 115 27 mislocalisation mislocalisation NN cord-326015-ky4y2xjt 115 28 . . . cord-326015-ky4y2xjt 116 1 Second second RB cord-326015-ky4y2xjt 116 2 , , , cord-326015-ky4y2xjt 116 3 as as IN cord-326015-ky4y2xjt 116 4 mentioned mention VBN cord-326015-ky4y2xjt 116 5 above above RB cord-326015-ky4y2xjt 116 6 , , , cord-326015-ky4y2xjt 116 7 Golgi Golgi NNP cord-326015-ky4y2xjt 116 8 residents resident NNS cord-326015-ky4y2xjt 116 9 can can MD cord-326015-ky4y2xjt 116 10 be be VB cord-326015-ky4y2xjt 116 11 readily readily RB cord-326015-ky4y2xjt 116 12 isolated isolate VBN cord-326015-ky4y2xjt 116 13 as as IN cord-326015-ky4y2xjt 116 14 detergent detergent NN cord-326015-ky4y2xjt 116 15 insoluble insoluble JJ cord-326015-ky4y2xjt 116 16 complexes complex NNS cord-326015-ky4y2xjt 116 17 [ [ -LRB- cord-326015-ky4y2xjt 116 18 33 33 CD cord-326015-ky4y2xjt 116 19 , , , cord-326015-ky4y2xjt 116 20 34 34 CD cord-326015-ky4y2xjt 116 21 ] ] -RRB- cord-326015-ky4y2xjt 116 22 . . . cord-326015-ky4y2xjt 117 1 These these DT cord-326015-ky4y2xjt 117 2 highly highly RB cord-326015-ky4y2xjt 117 3 oligomeric oligomeric JJ cord-326015-ky4y2xjt 117 4 structures structure NNS cord-326015-ky4y2xjt 117 5 can can MD cord-326015-ky4y2xjt 117 6 be be VB cord-326015-ky4y2xjt 117 7 disassembled disassemble VBN cord-326015-ky4y2xjt 117 8 / / WP cord-326015-ky4y2xjt 117 9 reassembled reassemble VBN cord-326015-ky4y2xjt 117 10 by by IN cord-326015-ky4y2xjt 117 11 the the DT cord-326015-ky4y2xjt 117 12 addition addition NN cord-326015-ky4y2xjt 117 13 / / SYM cord-326015-ky4y2xjt 117 14 removal removal NN cord-326015-ky4y2xjt 117 15 of of IN cord-326015-ky4y2xjt 117 16 salt salt NN cord-326015-ky4y2xjt 117 17 [ [ -LRB- cord-326015-ky4y2xjt 117 18 34 34 CD cord-326015-ky4y2xjt 117 19 ] ] -RRB- cord-326015-ky4y2xjt 117 20 . . . cord-326015-ky4y2xjt 118 1 Also also RB cord-326015-ky4y2xjt 118 2 , , , cord-326015-ky4y2xjt 118 3 full full JJ cord-326015-ky4y2xjt 118 4 - - HYPH cord-326015-ky4y2xjt 118 5 length length NN cord-326015-ky4y2xjt 118 6 GalT GalT NNP cord-326015-ky4y2xjt 118 7 can can MD cord-326015-ky4y2xjt 118 8 be be VB cord-326015-ky4y2xjt 118 9 crosslinked crosslinke VBN cord-326015-ky4y2xjt 118 10 into into IN cord-326015-ky4y2xjt 118 11 high high JJ cord-326015-ky4y2xjt 118 12 molecular molecular JJ cord-326015-ky4y2xjt 118 13 complexes complex NNS cord-326015-ky4y2xjt 118 14 [ [ -LRB- cord-326015-ky4y2xjt 118 15 35 35 CD cord-326015-ky4y2xjt 118 16 ] ] -RRB- cord-326015-ky4y2xjt 118 17 . . . cord-326015-ky4y2xjt 119 1 Third third RB cord-326015-ky4y2xjt 119 2 , , , cord-326015-ky4y2xjt 119 3 the the DT cord-326015-ky4y2xjt 119 4 medial medial JJ cord-326015-ky4y2xjt 119 5 enzymes enzyme NNS cord-326015-ky4y2xjt 119 6 , , , cord-326015-ky4y2xjt 119 7 NAGT NAGT NNP cord-326015-ky4y2xjt 119 8 I I NNP cord-326015-ky4y2xjt 119 9 and and CC cord-326015-ky4y2xjt 119 10 Mann Mann NNP cord-326015-ky4y2xjt 119 11 II II NNP cord-326015-ky4y2xjt 119 12 form form VBP cord-326015-ky4y2xjt 119 13 hetero hetero JJ cord-326015-ky4y2xjt 119 14 oligomers oligomer NNS cord-326015-ky4y2xjt 119 15 ( ( -LRB- cord-326015-ky4y2xjt 119 16 or or CC cord-326015-ky4y2xjt 119 17 kin kin NN cord-326015-ky4y2xjt 119 18 oligomers oligomer NNS cord-326015-ky4y2xjt 119 19 ) ) -RRB- cord-326015-ky4y2xjt 119 20 in in IN cord-326015-ky4y2xjt 119 21 vivo vivo NNP cord-326015-ky4y2xjt 119 22 [ [ -LRB- cord-326015-ky4y2xjt 119 23 36 36 CD cord-326015-ky4y2xjt 119 24 ] ] -RRB- cord-326015-ky4y2xjt 119 25 . . . cord-326015-ky4y2xjt 120 1 The the DT cord-326015-ky4y2xjt 120 2 domain domain NN cord-326015-ky4y2xjt 120 3 su¤cient su¤cient NNP cord-326015-ky4y2xjt 120 4 in in IN cord-326015-ky4y2xjt 120 5 mediating mediate VBG cord-326015-ky4y2xjt 120 6 this this DT cord-326015-ky4y2xjt 120 7 hetero hetero JJ cord-326015-ky4y2xjt 120 8 interaction interaction NN cord-326015-ky4y2xjt 120 9 was be VBD cord-326015-ky4y2xjt 120 10 shown show VBN cord-326015-ky4y2xjt 120 11 to to TO cord-326015-ky4y2xjt 120 12 reside reside VB cord-326015-ky4y2xjt 120 13 in in IN cord-326015-ky4y2xjt 120 14 the the DT cord-326015-ky4y2xjt 120 15 stalk stalk NN cord-326015-ky4y2xjt 120 16 region region NN cord-326015-ky4y2xjt 120 17 of of IN cord-326015-ky4y2xjt 120 18 NAGT NAGT NNP cord-326015-ky4y2xjt 121 1 I -PRON- PRP cord-326015-ky4y2xjt 121 2 [ [ -LRB- cord-326015-ky4y2xjt 121 3 37 37 CD cord-326015-ky4y2xjt 121 4 ] ] -RRB- cord-326015-ky4y2xjt 121 5 . . . cord-326015-ky4y2xjt 122 1 Similarly similarly RB cord-326015-ky4y2xjt 122 2 , , , cord-326015-ky4y2xjt 122 3 a a DT cord-326015-ky4y2xjt 122 4 family family NN cord-326015-ky4y2xjt 122 5 of of IN cord-326015-ky4y2xjt 122 6 small small JJ cord-326015-ky4y2xjt 122 7 membrane membrane NN cord-326015-ky4y2xjt 122 8 proteins protein NNS cord-326015-ky4y2xjt 122 9 , , , cord-326015-ky4y2xjt 122 10 the the DT cord-326015-ky4y2xjt 122 11 p24s p24s NNP cord-326015-ky4y2xjt 122 12 , , , cord-326015-ky4y2xjt 122 13 cycling cycle VBG cord-326015-ky4y2xjt 122 14 between between IN cord-326015-ky4y2xjt 122 15 the the DT cord-326015-ky4y2xjt 122 16 CGN CGN NNP cord-326015-ky4y2xjt 122 17 and and CC cord-326015-ky4y2xjt 122 18 the the DT cord-326015-ky4y2xjt 122 19 ER ER NNP cord-326015-ky4y2xjt 122 20 , , , cord-326015-ky4y2xjt 122 21 can can MD cord-326015-ky4y2xjt 122 22 be be VB cord-326015-ky4y2xjt 122 23 isolated isolate VBN cord-326015-ky4y2xjt 122 24 as as IN cord-326015-ky4y2xjt 122 25 detergent detergent NN cord-326015-ky4y2xjt 122 26 insoluble insoluble JJ cord-326015-ky4y2xjt 122 27 complexes complex NNS cord-326015-ky4y2xjt 122 28 and and CC cord-326015-ky4y2xjt 122 29 as as IN cord-326015-ky4y2xjt 122 30 with with IN cord-326015-ky4y2xjt 122 31 NAGT NAGT NNP cord-326015-ky4y2xjt 122 32 I I NNP cord-326015-ky4y2xjt 122 33 and and CC cord-326015-ky4y2xjt 122 34 Mann Mann NNP cord-326015-ky4y2xjt 122 35 II II NNP cord-326015-ky4y2xjt 122 36 , , , cord-326015-ky4y2xjt 122 37 they -PRON- PRP cord-326015-ky4y2xjt 122 38 also also RB cord-326015-ky4y2xjt 122 39 oligomerise oligomerise VBP cord-326015-ky4y2xjt 122 40 in in IN cord-326015-ky4y2xjt 122 41 vivo vivo NNP cord-326015-ky4y2xjt 122 42 [ [ -LRB- cord-326015-ky4y2xjt 122 43 34 34 CD cord-326015-ky4y2xjt 122 44 , , , cord-326015-ky4y2xjt 122 45 38 38 CD cord-326015-ky4y2xjt 122 46 ] ] -RRB- cord-326015-ky4y2xjt 122 47 . . . cord-326015-ky4y2xjt 123 1 In in IN cord-326015-ky4y2xjt 123 2 the the DT cord-326015-ky4y2xjt 123 3 context context NN cord-326015-ky4y2xjt 123 4 of of IN cord-326015-ky4y2xjt 123 5 cisternal cisternal JJ cord-326015-ky4y2xjt 123 6 maturation maturation NN cord-326015-ky4y2xjt 123 7 , , , cord-326015-ky4y2xjt 123 8 we -PRON- PRP cord-326015-ky4y2xjt 123 9 suggest suggest VBP cord-326015-ky4y2xjt 123 10 that that IN cord-326015-ky4y2xjt 123 11 oligomerisation oligomerisation IN cord-326015-ky4y2xjt 123 12 directly directly RB cord-326015-ky4y2xjt 123 13 promotes promote VBZ cord-326015-ky4y2xjt 123 14 incorporation incorporation NN cord-326015-ky4y2xjt 123 15 of of IN cord-326015-ky4y2xjt 123 16 residents resident NNS cord-326015-ky4y2xjt 123 17 into into IN cord-326015-ky4y2xjt 123 18 RTCs rtc NNS cord-326015-ky4y2xjt 123 19 and and CC cord-326015-ky4y2xjt 123 20 that that IN cord-326015-ky4y2xjt 123 21 this this DT cord-326015-ky4y2xjt 123 22 event event NN cord-326015-ky4y2xjt 123 23 is be VBZ cord-326015-ky4y2xjt 123 24 milieu milieu NN cord-326015-ky4y2xjt 123 25 induced induce VBN cord-326015-ky4y2xjt 123 26 . . . cord-326015-ky4y2xjt 124 1 This this DT cord-326015-ky4y2xjt 124 2 would would MD cord-326015-ky4y2xjt 124 3 provide provide VB cord-326015-ky4y2xjt 124 4 an an DT cord-326015-ky4y2xjt 124 5 explanation explanation NN cord-326015-ky4y2xjt 124 6 for for IN cord-326015-ky4y2xjt 124 7 individual individual JJ cord-326015-ky4y2xjt 124 8 gradients gradient NNS cord-326015-ky4y2xjt 124 9 exhibited exhibit VBN cord-326015-ky4y2xjt 124 10 by by IN cord-326015-ky4y2xjt 124 11 di¡erent di¡erent NNP cord-326015-ky4y2xjt 124 12 residents resident NNS cord-326015-ky4y2xjt 124 13 along along IN cord-326015-ky4y2xjt 124 14 the the DT cord-326015-ky4y2xjt 124 15 pathway pathway NN cord-326015-ky4y2xjt 124 16 . . . cord-326015-ky4y2xjt 125 1 There there EX cord-326015-ky4y2xjt 125 2 is be VBZ cord-326015-ky4y2xjt 125 3 a a DT cord-326015-ky4y2xjt 125 4 pH ph NN cord-326015-ky4y2xjt 125 5 as as RB cord-326015-ky4y2xjt 125 6 well well RB cord-326015-ky4y2xjt 125 7 as as IN cord-326015-ky4y2xjt 125 8 a a DT cord-326015-ky4y2xjt 125 9 lipid lipid NN cord-326015-ky4y2xjt 125 10 gradient gradient NN cord-326015-ky4y2xjt 125 11 ( ( -LRB- cord-326015-ky4y2xjt 125 12 see see VB cord-326015-ky4y2xjt 125 13 above above RB cord-326015-ky4y2xjt 125 14 ) ) -RRB- cord-326015-ky4y2xjt 125 15 in in IN cord-326015-ky4y2xjt 125 16 the the DT cord-326015-ky4y2xjt 125 17 Golgi Golgi NNP cord-326015-ky4y2xjt 125 18 apparatus apparatus NN cord-326015-ky4y2xjt 125 19 and and CC cord-326015-ky4y2xjt 125 20 these these DT cord-326015-ky4y2xjt 125 21 would would MD cord-326015-ky4y2xjt 125 22 over over IN cord-326015-ky4y2xjt 125 23 time time NN cord-326015-ky4y2xjt 125 24 trigger trigger VB cord-326015-ky4y2xjt 125 25 oligomerisation oligomerisation NN cord-326015-ky4y2xjt 125 26 and and CC cord-326015-ky4y2xjt 125 27 subsequent subsequent JJ cord-326015-ky4y2xjt 125 28 incorporation incorporation NN cord-326015-ky4y2xjt 125 29 of of IN cord-326015-ky4y2xjt 125 30 residents resident NNS cord-326015-ky4y2xjt 125 31 into into IN cord-326015-ky4y2xjt 125 32 RTCs rtc NNS cord-326015-ky4y2xjt 125 33 . . . cord-326015-ky4y2xjt 126 1 We -PRON- PRP cord-326015-ky4y2xjt 126 2 further further RB cord-326015-ky4y2xjt 126 3 suggest suggest VBP cord-326015-ky4y2xjt 126 4 that that IN cord-326015-ky4y2xjt 126 5 such such JJ cord-326015-ky4y2xjt 126 6 oligomerisation oligomerisation NN cord-326015-ky4y2xjt 126 7 results result NNS cord-326015-ky4y2xjt 126 8 in in IN cord-326015-ky4y2xjt 126 9 an an DT cord-326015-ky4y2xjt 126 10 increased increase VBN cord-326015-ky4y2xjt 126 11 ability ability NN cord-326015-ky4y2xjt 126 12 of of IN cord-326015-ky4y2xjt 126 13 the the DT cord-326015-ky4y2xjt 126 14 residents resident NNS cord-326015-ky4y2xjt 126 15 to to TO cord-326015-ky4y2xjt 126 16 bind bind VB cord-326015-ky4y2xjt 126 17 coat coat NN cord-326015-ky4y2xjt 126 18 components component NNS cord-326015-ky4y2xjt 126 19 needed need VBN cord-326015-ky4y2xjt 126 20 to to TO cord-326015-ky4y2xjt 126 21 form form VB cord-326015-ky4y2xjt 126 22 an an DT cord-326015-ky4y2xjt 126 23 RTC RTC NNP cord-326015-ky4y2xjt 126 24 through through IN cord-326015-ky4y2xjt 126 25 cooperative cooperative JJ cord-326015-ky4y2xjt 126 26 binding binding NN cord-326015-ky4y2xjt 126 27 . . . cord-326015-ky4y2xjt 127 1 Thus thus RB cord-326015-ky4y2xjt 127 2 , , , cord-326015-ky4y2xjt 127 3 residents resident NNS cord-326015-ky4y2xjt 127 4 would would MD cord-326015-ky4y2xjt 127 5 be be VB cord-326015-ky4y2xjt 127 6 distilled distil VBN cord-326015-ky4y2xjt 127 7 at at IN cord-326015-ky4y2xjt 127 8 various various JJ cord-326015-ky4y2xjt 127 9 levels level NNS cord-326015-ky4y2xjt 127 10 of of IN cord-326015-ky4y2xjt 127 11 the the DT cord-326015-ky4y2xjt 127 12 pathway pathway NN cord-326015-ky4y2xjt 127 13 depending depend VBG cord-326015-ky4y2xjt 127 14 on on IN cord-326015-ky4y2xjt 127 15 their -PRON- PRP$ cord-326015-ky4y2xjt 127 16 particular particular JJ cord-326015-ky4y2xjt 127 17 ability ability NN cord-326015-ky4y2xjt 127 18 to to IN cord-326015-ky4y2xjt 127 19 oligomerise oligomerise NN cord-326015-ky4y2xjt 127 20 and and CC cord-326015-ky4y2xjt 127 21 directly directly RB cord-326015-ky4y2xjt 127 22 bind bind VB cord-326015-ky4y2xjt 127 23 coat coat NN cord-326015-ky4y2xjt 127 24 components component NNS cord-326015-ky4y2xjt 127 25 . . . cord-326015-ky4y2xjt 128 1 That that IN cord-326015-ky4y2xjt 128 2 such such JJ cord-326015-ky4y2xjt 128 3 direct direct JJ cord-326015-ky4y2xjt 128 4 binding binding NN cord-326015-ky4y2xjt 128 5 is be VBZ cord-326015-ky4y2xjt 128 6 possible possible JJ cord-326015-ky4y2xjt 128 7 has have VBZ cord-326015-ky4y2xjt 128 8 been be VBN cord-326015-ky4y2xjt 128 9 shown show VBN cord-326015-ky4y2xjt 128 10 for for IN cord-326015-ky4y2xjt 128 11 several several JJ cord-326015-ky4y2xjt 128 12 residents resident NNS cord-326015-ky4y2xjt 128 13 although although IN cord-326015-ky4y2xjt 128 14 mainly mainly RB cord-326015-ky4y2xjt 128 15 in in IN cord-326015-ky4y2xjt 128 16 the the DT cord-326015-ky4y2xjt 128 17 early early JJ cord-326015-ky4y2xjt 128 18 parts part NNS cord-326015-ky4y2xjt 128 19 of of IN cord-326015-ky4y2xjt 128 20 the the DT cord-326015-ky4y2xjt 128 21 pathway pathway NN cord-326015-ky4y2xjt 128 22 ( ( -LRB- cord-326015-ky4y2xjt 128 23 see see VB cord-326015-ky4y2xjt 128 24 below below RB cord-326015-ky4y2xjt 128 25 ) ) -RRB- cord-326015-ky4y2xjt 128 26 . . . cord-326015-ky4y2xjt 129 1 Following follow VBG cord-326015-ky4y2xjt 129 2 the`distillation the`distillation NNP cord-326015-ky4y2xjt 129 3 hypothesis hypothesis NN cord-326015-ky4y2xjt 129 4 ' ' '' cord-326015-ky4y2xjt 129 5 which which WDT cord-326015-ky4y2xjt 129 6 postulated postulate VBD cord-326015-ky4y2xjt 129 7 selective selective JJ cord-326015-ky4y2xjt 129 8 retrieval retrieval NN cord-326015-ky4y2xjt 129 9 of of IN cord-326015-ky4y2xjt 129 10 residents resident NNS cord-326015-ky4y2xjt 129 11 against against IN cord-326015-ky4y2xjt 129 12 a a DT cord-326015-ky4y2xjt 129 13 forward forward NN cord-326015-ky4y2xjt 129 14 £ £ $ cord-326015-ky4y2xjt 129 15 ow ow NN cord-326015-ky4y2xjt 129 16 of of IN cord-326015-ky4y2xjt 129 17 cargo cargo NN cord-326015-ky4y2xjt 129 18 [ [ -LRB- cord-326015-ky4y2xjt 129 19 39 39 CD cord-326015-ky4y2xjt 129 20 ] ] -RRB- cord-326015-ky4y2xjt 129 21 , , , cord-326015-ky4y2xjt 129 22 ER ER NNP cord-326015-ky4y2xjt 129 23 localisation localisation NN cord-326015-ky4y2xjt 129 24 signals signal NNS cord-326015-ky4y2xjt 129 25 were be VBD cord-326015-ky4y2xjt 129 26 identi¢ed identi¢ed . cord-326015-ky4y2xjt 129 27 in in IN cord-326015-ky4y2xjt 129 28 both both CC cord-326015-ky4y2xjt 129 29 soluble soluble JJ cord-326015-ky4y2xjt 129 30 [ [ -LRB- cord-326015-ky4y2xjt 129 31 40 40 CD cord-326015-ky4y2xjt 129 32 ] ] -RRB- cord-326015-ky4y2xjt 129 33 as as RB cord-326015-ky4y2xjt 129 34 well well RB cord-326015-ky4y2xjt 129 35 as as IN cord-326015-ky4y2xjt 129 36 membrane membrane NN cord-326015-ky4y2xjt 129 37 proteins protein NNS cord-326015-ky4y2xjt 129 38 [ [ -LRB- cord-326015-ky4y2xjt 129 39 41 41 CD cord-326015-ky4y2xjt 129 40 , , , cord-326015-ky4y2xjt 129 41 42 42 CD cord-326015-ky4y2xjt 129 42 ] ] -RRB- cord-326015-ky4y2xjt 129 43 . . . cord-326015-ky4y2xjt 130 1 These these DT cord-326015-ky4y2xjt 130 2 were be VBD cord-326015-ky4y2xjt 130 3 shown show VBN cord-326015-ky4y2xjt 130 4 to to TO cord-326015-ky4y2xjt 130 5 confer confer VB cord-326015-ky4y2xjt 130 6 ER ER NNP cord-326015-ky4y2xjt 130 7 localisation localisation NN cord-326015-ky4y2xjt 130 8 when when WRB cord-326015-ky4y2xjt 130 9 appended append VBN cord-326015-ky4y2xjt 130 10 to to IN cord-326015-ky4y2xjt 130 11 reporter reporter NN cord-326015-ky4y2xjt 130 12 molecules molecule NNS cord-326015-ky4y2xjt 130 13 acting act VBG cord-326015-ky4y2xjt 130 14 as as IN cord-326015-ky4y2xjt 130 15 retrieval retrieval NN cord-326015-ky4y2xjt 130 16 signals signal NNS cord-326015-ky4y2xjt 130 17 [ [ -LRB- cord-326015-ky4y2xjt 130 18 43 43 CD cord-326015-ky4y2xjt 130 19 , , , cord-326015-ky4y2xjt 130 20 44 44 CD cord-326015-ky4y2xjt 130 21 ] ] -RRB- cord-326015-ky4y2xjt 130 22 . . . cord-326015-ky4y2xjt 131 1 For for IN cord-326015-ky4y2xjt 131 2 lumenal lumenal JJ cord-326015-ky4y2xjt 131 3 ER ER NNP cord-326015-ky4y2xjt 131 4 residents resident NNS cord-326015-ky4y2xjt 131 5 , , , cord-326015-ky4y2xjt 131 6 a a DT cord-326015-ky4y2xjt 131 7 carboxyterminal carboxyterminal JJ cord-326015-ky4y2xjt 131 8 KDEL KDEL NNP cord-326015-ky4y2xjt 131 9 motif motif NN cord-326015-ky4y2xjt 131 10 was be VBD cord-326015-ky4y2xjt 131 11 shown show VBN cord-326015-ky4y2xjt 131 12 to to TO cord-326015-ky4y2xjt 131 13 bind bind VB cord-326015-ky4y2xjt 131 14 a a DT cord-326015-ky4y2xjt 131 15 receptor receptor NN cord-326015-ky4y2xjt 131 16 [ [ -LRB- cord-326015-ky4y2xjt 131 17 45 45 CD cord-326015-ky4y2xjt 131 18 ] ] -RRB- cord-326015-ky4y2xjt 131 19 localised localise VBN cord-326015-ky4y2xjt 131 20 to to IN cord-326015-ky4y2xjt 131 21 the the DT cord-326015-ky4y2xjt 131 22 early early JJ cord-326015-ky4y2xjt 131 23 part part NN cord-326015-ky4y2xjt 131 24 of of IN cord-326015-ky4y2xjt 131 25 the the DT cord-326015-ky4y2xjt 131 26 Golgi Golgi NNP cord-326015-ky4y2xjt 131 27 apparatus apparatus NN cord-326015-ky4y2xjt 131 28 [ [ -LRB- cord-326015-ky4y2xjt 131 29 46 46 CD cord-326015-ky4y2xjt 131 30 , , , cord-326015-ky4y2xjt 131 31 47 47 CD cord-326015-ky4y2xjt 131 32 ] ] -RRB- cord-326015-ky4y2xjt 131 33 . . . cord-326015-ky4y2xjt 132 1 Likewise likewise RB cord-326015-ky4y2xjt 132 2 , , , cord-326015-ky4y2xjt 132 3 for for IN cord-326015-ky4y2xjt 132 4 type type NN cord-326015-ky4y2xjt 132 5 I -PRON- PRP cord-326015-ky4y2xjt 132 6 membrane membrane NN cord-326015-ky4y2xjt 132 7 proteins protein NNS cord-326015-ky4y2xjt 132 8 , , , cord-326015-ky4y2xjt 132 9 the the DT cord-326015-ky4y2xjt 132 10 retrieval retrieval NN cord-326015-ky4y2xjt 132 11 motif motif NN cord-326015-ky4y2xjt 132 12 K(X)KXX k(x)kxx WDT cord-326015-ky4y2xjt 132 13 was be VBD cord-326015-ky4y2xjt 132 14 thought think VBN cord-326015-ky4y2xjt 132 15 to to TO cord-326015-ky4y2xjt 132 16 bind bind VB cord-326015-ky4y2xjt 132 17 a a DT cord-326015-ky4y2xjt 132 18 receptor receptor NN cord-326015-ky4y2xjt 132 19 oriented orient VBN cord-326015-ky4y2xjt 132 20 towards towards IN cord-326015-ky4y2xjt 132 21 the the DT cord-326015-ky4y2xjt 132 22 cytoplasm cytoplasm NN cord-326015-ky4y2xjt 132 23 . . . cord-326015-ky4y2xjt 133 1 Then then RB cord-326015-ky4y2xjt 133 2 , , , cord-326015-ky4y2xjt 133 3 a a DT cord-326015-ky4y2xjt 133 4 groundbreaking groundbreaking JJ cord-326015-ky4y2xjt 133 5 discovery discovery NN cord-326015-ky4y2xjt 133 6 by by IN cord-326015-ky4y2xjt 133 7 Cosson Cosson NNP cord-326015-ky4y2xjt 133 8 and and CC cord-326015-ky4y2xjt 133 9 co co NNS cord-326015-ky4y2xjt 133 10 - - NNS cord-326015-ky4y2xjt 133 11 workers worker NNS cord-326015-ky4y2xjt 133 12 showed show VBD cord-326015-ky4y2xjt 133 13 that that IN cord-326015-ky4y2xjt 133 14 the the DT cord-326015-ky4y2xjt 133 15 K(X)KXX K(X)KXX NNP cord-326015-ky4y2xjt 133 16 motif motif NN cord-326015-ky4y2xjt 133 17 interacts interact VBZ cord-326015-ky4y2xjt 133 18 with with IN cord-326015-ky4y2xjt 133 19 coat coat NN cord-326015-ky4y2xjt 133 20 components component NNS cord-326015-ky4y2xjt 133 21 of of IN cord-326015-ky4y2xjt 133 22 the the DT cord-326015-ky4y2xjt 133 23 COP cop NN cord-326015-ky4y2xjt 133 24 I -PRON- PRP cord-326015-ky4y2xjt 133 25 coatomer coatomer VBD cord-326015-ky4y2xjt 133 26 directly directly RB cord-326015-ky4y2xjt 133 27 [ [ -LRB- cord-326015-ky4y2xjt 133 28 48 48 CD cord-326015-ky4y2xjt 133 29 ] ] -RRB- cord-326015-ky4y2xjt 133 30 . . . cord-326015-ky4y2xjt 134 1 Moreover moreover RB cord-326015-ky4y2xjt 134 2 , , , cord-326015-ky4y2xjt 134 3 genetic genetic JJ cord-326015-ky4y2xjt 134 4 evidence evidence NN cord-326015-ky4y2xjt 134 5 cemented cement VBD cord-326015-ky4y2xjt 134 6 this this DT cord-326015-ky4y2xjt 134 7 ¢nding ¢nding NN cord-326015-ky4y2xjt 134 8 demonstrating demonstrate VBG cord-326015-ky4y2xjt 134 9 that that DT cord-326015-ky4y2xjt 134 10 COP cop NN cord-326015-ky4y2xjt 134 11 I -PRON- PRP cord-326015-ky4y2xjt 134 12 coatomer coatomer VBD cord-326015-ky4y2xjt 134 13 functionally functionally RB cord-326015-ky4y2xjt 134 14 mediates mediate VBZ cord-326015-ky4y2xjt 134 15 retrieval retrieval NN cord-326015-ky4y2xjt 134 16 [ [ -LRB- cord-326015-ky4y2xjt 134 17 49 49 CD cord-326015-ky4y2xjt 134 18 ] ] -RRB- cord-326015-ky4y2xjt 134 19 . . . cord-326015-ky4y2xjt 135 1 As as IN cord-326015-ky4y2xjt 135 2 this this DT cord-326015-ky4y2xjt 135 3 form form NN cord-326015-ky4y2xjt 135 4 of of IN cord-326015-ky4y2xjt 135 5 coatomer coatomer NN cord-326015-ky4y2xjt 135 6 is be VBZ cord-326015-ky4y2xjt 135 7 found find VBN cord-326015-ky4y2xjt 135 8 on on IN cord-326015-ky4y2xjt 135 9 Golgi Golgi NNP cord-326015-ky4y2xjt 135 10 associated associated JJ cord-326015-ky4y2xjt 135 11 transport transport NN cord-326015-ky4y2xjt 135 12 vesicles vesicle NNS cord-326015-ky4y2xjt 135 13 [ [ -LRB- cord-326015-ky4y2xjt 135 14 50 50 CD cord-326015-ky4y2xjt 135 15 ] ] -RRB- cord-326015-ky4y2xjt 135 16 , , , cord-326015-ky4y2xjt 135 17 COP cop NN cord-326015-ky4y2xjt 135 18 I -PRON- PRP cord-326015-ky4y2xjt 135 19 vesicles vesicle NNS cord-326015-ky4y2xjt 135 20 constitute constitute VBP cord-326015-ky4y2xjt 135 21 RTCs rtc NNS cord-326015-ky4y2xjt 135 22 . . . cord-326015-ky4y2xjt 136 1 The the DT cord-326015-ky4y2xjt 136 2 presence presence NN cord-326015-ky4y2xjt 136 3 of of IN cord-326015-ky4y2xjt 136 4 K(X)KXX k(x)kxx PRP cord-326015-ky4y2xjt 136 5 or or CC cord-326015-ky4y2xjt 136 6 related relate VBN cord-326015-ky4y2xjt 136 7 signals signal NNS cord-326015-ky4y2xjt 136 8 on on IN cord-326015-ky4y2xjt 136 9 membrane membrane NN cord-326015-ky4y2xjt 136 10 proteins protein NNS cord-326015-ky4y2xjt 136 11 other other JJ cord-326015-ky4y2xjt 136 12 than than IN cord-326015-ky4y2xjt 136 13 ER ER NNP cord-326015-ky4y2xjt 136 14 residents resident NNS cord-326015-ky4y2xjt 136 15 allows allow VBZ cord-326015-ky4y2xjt 136 16 for for IN cord-326015-ky4y2xjt 136 17 the the DT cord-326015-ky4y2xjt 136 18 possibility possibility NN cord-326015-ky4y2xjt 136 19 that that IN cord-326015-ky4y2xjt 136 20 this this DT cord-326015-ky4y2xjt 136 21 motif motif NN cord-326015-ky4y2xjt 136 22 also also RB cord-326015-ky4y2xjt 136 23 acts act VBZ cord-326015-ky4y2xjt 136 24 later later RB cord-326015-ky4y2xjt 136 25 in in IN cord-326015-ky4y2xjt 136 26 the the DT cord-326015-ky4y2xjt 136 27 pathway pathway NN cord-326015-ky4y2xjt 136 28 . . . cord-326015-ky4y2xjt 137 1 Both both DT cord-326015-ky4y2xjt 137 2 ERGIC-53 ergic-53 CD cord-326015-ky4y2xjt 137 3 [ [ -LRB- cord-326015-ky4y2xjt 137 4 51 51 CD cord-326015-ky4y2xjt 137 5 ] ] -RRB- cord-326015-ky4y2xjt 137 6 and and CC cord-326015-ky4y2xjt 137 7 some some DT cord-326015-ky4y2xjt 137 8 members member NNS cord-326015-ky4y2xjt 137 9 of of IN cord-326015-ky4y2xjt 137 10 the the DT cord-326015-ky4y2xjt 137 11 p24 p24 NN cord-326015-ky4y2xjt 137 12 protein protein NN cord-326015-ky4y2xjt 137 13 family family NN cord-326015-ky4y2xjt 137 14 display display NN cord-326015-ky4y2xjt 137 15 K(X)KXX k(x)kxx IN cord-326015-ky4y2xjt 137 16 retrieval retrieval NN cord-326015-ky4y2xjt 137 17 motifs motif NNS cord-326015-ky4y2xjt 137 18 and and CC cord-326015-ky4y2xjt 137 19 reside reside VB cord-326015-ky4y2xjt 137 20 in in IN cord-326015-ky4y2xjt 137 21 the the DT cord-326015-ky4y2xjt 137 22 interface interface NN cord-326015-ky4y2xjt 137 23 between between IN cord-326015-ky4y2xjt 137 24 the the DT cord-326015-ky4y2xjt 137 25 ER ER NNP cord-326015-ky4y2xjt 137 26 and and CC cord-326015-ky4y2xjt 137 27 the the DT cord-326015-ky4y2xjt 137 28 Golgi Golgi NNP cord-326015-ky4y2xjt 137 29 apparatus apparatus NN cord-326015-ky4y2xjt 137 30 [ [ -LRB- cord-326015-ky4y2xjt 137 31 34 34 CD cord-326015-ky4y2xjt 137 32 , , , cord-326015-ky4y2xjt 137 33 52 52 CD cord-326015-ky4y2xjt 137 34 , , , cord-326015-ky4y2xjt 137 35 53 53 CD cord-326015-ky4y2xjt 137 36 ] ] -RRB- cord-326015-ky4y2xjt 137 37 . . . cord-326015-ky4y2xjt 138 1 Surprisingly surprisingly RB cord-326015-ky4y2xjt 138 2 , , , cord-326015-ky4y2xjt 138 3 both both DT cord-326015-ky4y2xjt 138 4 ERGIC-53 ERGIC-53 NNP cord-326015-ky4y2xjt 138 5 and and CC cord-326015-ky4y2xjt 138 6 the the DT cord-326015-ky4y2xjt 138 7 p24s p24s NNP cord-326015-ky4y2xjt 138 8 not not RB cord-326015-ky4y2xjt 138 9 only only RB cord-326015-ky4y2xjt 138 10 use use VB cord-326015-ky4y2xjt 138 11 K(X)KXX k(x)kxx IN cord-326015-ky4y2xjt 138 12 related related JJ cord-326015-ky4y2xjt 138 13 signals signal NNS cord-326015-ky4y2xjt 138 14 for for IN cord-326015-ky4y2xjt 138 15 their -PRON- PRP$ cord-326015-ky4y2xjt 138 16 steady steady JJ cord-326015-ky4y2xjt 138 17 state state NN cord-326015-ky4y2xjt 138 18 localisation localisation NN cord-326015-ky4y2xjt 138 19 , , , cord-326015-ky4y2xjt 138 20 but but CC cord-326015-ky4y2xjt 138 21 further further JJ cord-326015-ky4y2xjt 138 22 dissection dissection NN cord-326015-ky4y2xjt 138 23 of of IN cord-326015-ky4y2xjt 138 24 their -PRON- PRP$ cord-326015-ky4y2xjt 138 25 cytoplasmic cytoplasmic JJ cord-326015-ky4y2xjt 138 26 domains domain NNS cord-326015-ky4y2xjt 138 27 revealed reveal VBD cord-326015-ky4y2xjt 138 28 a a DT cord-326015-ky4y2xjt 138 29 signal signal NN cord-326015-ky4y2xjt 138 30 which which WDT cord-326015-ky4y2xjt 138 31 acts act VBZ cord-326015-ky4y2xjt 138 32 in in IN cord-326015-ky4y2xjt 138 33 the the DT cord-326015-ky4y2xjt 138 34 opposite opposite JJ cord-326015-ky4y2xjt 138 35 direction direction NN cord-326015-ky4y2xjt 138 36 . . . cord-326015-ky4y2xjt 139 1 Both both DT cord-326015-ky4y2xjt 139 2 ERGIC-53 ERGIC-53 NNS cord-326015-ky4y2xjt 139 3 and and CC cord-326015-ky4y2xjt 139 4 p24 p24 NN cord-326015-ky4y2xjt 139 5 family family NN cord-326015-ky4y2xjt 139 6 members member NNS cord-326015-ky4y2xjt 139 7 interact interact VBP cord-326015-ky4y2xjt 139 8 directly directly RB cord-326015-ky4y2xjt 139 9 with with IN cord-326015-ky4y2xjt 139 10 Sec23 Sec23 NNP cord-326015-ky4y2xjt 139 11 , , , cord-326015-ky4y2xjt 139 12 a a DT cord-326015-ky4y2xjt 139 13 component component NN cord-326015-ky4y2xjt 139 14 of of IN cord-326015-ky4y2xjt 139 15 the the DT cord-326015-ky4y2xjt 139 16 COP cop NN cord-326015-ky4y2xjt 139 17 II II NNP cord-326015-ky4y2xjt 139 18 coat coat NN cord-326015-ky4y2xjt 139 19 involved involve VBN cord-326015-ky4y2xjt 139 20 in in IN cord-326015-ky4y2xjt 139 21 budding bud VBG cord-326015-ky4y2xjt 139 22 from from IN cord-326015-ky4y2xjt 139 23 the the DT cord-326015-ky4y2xjt 139 24 ER ER NNP cord-326015-ky4y2xjt 139 25 [ [ -LRB- cord-326015-ky4y2xjt 139 26 34 34 CD cord-326015-ky4y2xjt 139 27 , , , cord-326015-ky4y2xjt 139 28 54 54 CD cord-326015-ky4y2xjt 139 29 ] ] -RRB- cord-326015-ky4y2xjt 139 30 . . . cord-326015-ky4y2xjt 140 1 This this DT cord-326015-ky4y2xjt 140 2 suggests suggest VBZ cord-326015-ky4y2xjt 140 3 that that IN cord-326015-ky4y2xjt 140 4 their -PRON- PRP$ cord-326015-ky4y2xjt 140 5 cytoplasmic cytoplasmic JJ cord-326015-ky4y2xjt 140 6 domains domain NNS cord-326015-ky4y2xjt 140 7 contain contain VBP cord-326015-ky4y2xjt 140 8 a a DT cord-326015-ky4y2xjt 140 9 positive positive JJ cord-326015-ky4y2xjt 140 10 export export NN cord-326015-ky4y2xjt 140 11 signal signal NN cord-326015-ky4y2xjt 140 12 and and CC cord-326015-ky4y2xjt 140 13 mutation mutation NN cord-326015-ky4y2xjt 140 14 of of IN cord-326015-ky4y2xjt 140 15 this this DT cord-326015-ky4y2xjt 140 16 leads lead VBZ cord-326015-ky4y2xjt 140 17 to to IN cord-326015-ky4y2xjt 140 18 accumulation accumulation NN cord-326015-ky4y2xjt 140 19 in in IN cord-326015-ky4y2xjt 140 20 the the DT cord-326015-ky4y2xjt 140 21 ER er NN cord-326015-ky4y2xjt 140 22 . . . cord-326015-ky4y2xjt 141 1 Thus thus RB cord-326015-ky4y2xjt 141 2 , , , cord-326015-ky4y2xjt 141 3 the the DT cord-326015-ky4y2xjt 141 4 combination combination NN cord-326015-ky4y2xjt 141 5 of of IN cord-326015-ky4y2xjt 141 6 an an DT cord-326015-ky4y2xjt 141 7 export export NN cord-326015-ky4y2xjt 141 8 and and CC cord-326015-ky4y2xjt 141 9 a a DT cord-326015-ky4y2xjt 141 10 retrieval retrieval NN cord-326015-ky4y2xjt 141 11 signal signal NN cord-326015-ky4y2xjt 141 12 ensures ensure VBZ cord-326015-ky4y2xjt 141 13 that that IN cord-326015-ky4y2xjt 141 14 ERGIC-53 ERGIC-53 NNP cord-326015-ky4y2xjt 141 15 and and CC cord-326015-ky4y2xjt 141 16 the the DT cord-326015-ky4y2xjt 141 17 p24s p24s ADD cord-326015-ky4y2xjt 141 18 localise localise NN cord-326015-ky4y2xjt 141 19 to to IN cord-326015-ky4y2xjt 141 20 the the DT cord-326015-ky4y2xjt 141 21 interface interface NN cord-326015-ky4y2xjt 141 22 between between IN cord-326015-ky4y2xjt 141 23 ER ER NNP cord-326015-ky4y2xjt 141 24 and and CC cord-326015-ky4y2xjt 141 25 Golgi Golgi NNP cord-326015-ky4y2xjt 141 26 apparatus apparatus NN cord-326015-ky4y2xjt 141 27 through through IN cord-326015-ky4y2xjt 141 28 constant constant JJ cord-326015-ky4y2xjt 141 29 cycling cycling NN cord-326015-ky4y2xjt 141 30 . . . cord-326015-ky4y2xjt 142 1 Do do VBP cord-326015-ky4y2xjt 142 2 other other JJ cord-326015-ky4y2xjt 142 3 Golgi Golgi NNP cord-326015-ky4y2xjt 142 4 resident resident NN cord-326015-ky4y2xjt 142 5 proteins protein NNS cord-326015-ky4y2xjt 142 6 display display VBP cord-326015-ky4y2xjt 142 7 similar similar JJ cord-326015-ky4y2xjt 142 8 signals signal NNS cord-326015-ky4y2xjt 142 9 ? ? . cord-326015-ky4y2xjt 143 1 In in IN cord-326015-ky4y2xjt 143 2 terms term NNS cord-326015-ky4y2xjt 143 3 of of IN cord-326015-ky4y2xjt 143 4 ER ER NNP cord-326015-ky4y2xjt 143 5 export export NN cord-326015-ky4y2xjt 143 6 signals signal NNS cord-326015-ky4y2xjt 143 7 , , , cord-326015-ky4y2xjt 143 8 it -PRON- PRP cord-326015-ky4y2xjt 143 9 appears appear VBZ cord-326015-ky4y2xjt 143 10 that that IN cord-326015-ky4y2xjt 143 11 Golgi Golgi NNP cord-326015-ky4y2xjt 143 12 glycosylation glycosylation NN cord-326015-ky4y2xjt 143 13 enzymes enzyme NNS cord-326015-ky4y2xjt 143 14 do do VBP cord-326015-ky4y2xjt 143 15 [ [ -LRB- cord-326015-ky4y2xjt 143 16 34 34 CD cord-326015-ky4y2xjt 143 17 ] ] -RRB- cord-326015-ky4y2xjt 143 18 . . . cord-326015-ky4y2xjt 144 1 The the DT cord-326015-ky4y2xjt 144 2 cytoplasmic cytoplasmic JJ cord-326015-ky4y2xjt 144 3 tails tail NNS cord-326015-ky4y2xjt 144 4 of of IN cord-326015-ky4y2xjt 144 5 these these DT cord-326015-ky4y2xjt 144 6 proteins protein NNS cord-326015-ky4y2xjt 144 7 also also RB cord-326015-ky4y2xjt 144 8 bound bind VBN cord-326015-ky4y2xjt 144 9 Sec23 Sec23 NNP cord-326015-ky4y2xjt 144 10 , , , cord-326015-ky4y2xjt 144 11 probably probably RB cord-326015-ky4y2xjt 144 12 ensuring ensure VBG cord-326015-ky4y2xjt 144 13 their -PRON- PRP$ cord-326015-ky4y2xjt 144 14 rapid rapid JJ cord-326015-ky4y2xjt 144 15 export export NN cord-326015-ky4y2xjt 144 16 from from IN cord-326015-ky4y2xjt 144 17 the the DT cord-326015-ky4y2xjt 144 18 ER ER NNP cord-326015-ky4y2xjt 144 19 after after IN cord-326015-ky4y2xjt 144 20 synthesis synthesis NN cord-326015-ky4y2xjt 144 21 . . . cord-326015-ky4y2xjt 145 1 There there EX cord-326015-ky4y2xjt 145 2 is be VBZ cord-326015-ky4y2xjt 145 3 also also RB cord-326015-ky4y2xjt 145 4 evidence evidence NN cord-326015-ky4y2xjt 145 5 for for IN cord-326015-ky4y2xjt 145 6 retrieval retrieval NN cord-326015-ky4y2xjt 145 7 [ [ -LRB- cord-326015-ky4y2xjt 145 8 55 55 CD cord-326015-ky4y2xjt 145 9 ^ ^ SYM cord-326015-ky4y2xjt 145 10 57 57 CD cord-326015-ky4y2xjt 145 11 ] ] -RRB- cord-326015-ky4y2xjt 145 12 though though IN cord-326015-ky4y2xjt 145 13 future future JJ cord-326015-ky4y2xjt 145 14 analysis analysis NN cord-326015-ky4y2xjt 145 15 will will MD cord-326015-ky4y2xjt 145 16 reveal reveal VB cord-326015-ky4y2xjt 145 17 whether whether IN cord-326015-ky4y2xjt 145 18 this this DT cord-326015-ky4y2xjt 145 19 is be VBZ cord-326015-ky4y2xjt 145 20 mediated mediate VBN cord-326015-ky4y2xjt 145 21 by by IN cord-326015-ky4y2xjt 145 22 COP cop NN cord-326015-ky4y2xjt 145 23 I -PRON- PRP cord-326015-ky4y2xjt 145 24 vesicles vesicle VBZ cord-326015-ky4y2xjt 145 25 . . . cord-326015-ky4y2xjt 146 1 6 6 LS cord-326015-ky4y2xjt 146 2 . . . cord-326015-ky4y2xjt 147 1 Recycling recycle VBG cord-326015-ky4y2xjt 147 2 through through IN cord-326015-ky4y2xjt 147 3 the the DT cord-326015-ky4y2xjt 147 4 ER ER NNP cord-326015-ky4y2xjt 147 5 As as IN cord-326015-ky4y2xjt 147 6 Golgi Golgi NNP cord-326015-ky4y2xjt 147 7 residents resident NNS cord-326015-ky4y2xjt 147 8 redistribute redistribute VBP cord-326015-ky4y2xjt 147 9 to to IN cord-326015-ky4y2xjt 147 10 the the DT cord-326015-ky4y2xjt 147 11 ER ER NNP cord-326015-ky4y2xjt 147 12 upon upon IN cord-326015-ky4y2xjt 147 13 brefeldin brefeldin NNP cord-326015-ky4y2xjt 148 1 A a DT cord-326015-ky4y2xjt 148 2 treatment treatment NN cord-326015-ky4y2xjt 148 3 , , , cord-326015-ky4y2xjt 148 4 it -PRON- PRP cord-326015-ky4y2xjt 148 5 was be VBD cord-326015-ky4y2xjt 148 6 proposed propose VBN cord-326015-ky4y2xjt 148 7 that that IN cord-326015-ky4y2xjt 148 8 this this DT cord-326015-ky4y2xjt 148 9 fungal fungal JJ cord-326015-ky4y2xjt 148 10 metabolite metabolite NN cord-326015-ky4y2xjt 148 11 highlights highlight VBZ cord-326015-ky4y2xjt 148 12 an an DT cord-326015-ky4y2xjt 148 13 already already RB cord-326015-ky4y2xjt 148 14 existing exist VBG cord-326015-ky4y2xjt 148 15 pathway pathway NN cord-326015-ky4y2xjt 148 16 of of IN cord-326015-ky4y2xjt 148 17 limited limited JJ cord-326015-ky4y2xjt 148 18 fusion fusion NN cord-326015-ky4y2xjt 148 19 between between IN cord-326015-ky4y2xjt 148 20 the the DT cord-326015-ky4y2xjt 148 21 Golgi Golgi NNP cord-326015-ky4y2xjt 148 22 apparatus apparatus NN cord-326015-ky4y2xjt 148 23 and and CC cord-326015-ky4y2xjt 148 24 the the DT cord-326015-ky4y2xjt 148 25 ER ER NNP cord-326015-ky4y2xjt 148 26 [ [ -LRB- cord-326015-ky4y2xjt 148 27 58 58 CD cord-326015-ky4y2xjt 148 28 ] ] -RRB- cord-326015-ky4y2xjt 148 29 . . . cord-326015-ky4y2xjt 149 1 This this DT cord-326015-ky4y2xjt 149 2 would would MD cord-326015-ky4y2xjt 149 3 allow allow VB cord-326015-ky4y2xjt 149 4 Golgi Golgi NNP cord-326015-ky4y2xjt 149 5 residents resident NNS cord-326015-ky4y2xjt 149 6 to to TO cord-326015-ky4y2xjt 149 7 enter enter VB cord-326015-ky4y2xjt 149 8 directly directly RB cord-326015-ky4y2xjt 149 9 into into IN cord-326015-ky4y2xjt 149 10 the the DT cord-326015-ky4y2xjt 149 11 ER er NN cord-326015-ky4y2xjt 149 12 and and CC cord-326015-ky4y2xjt 149 13 subsequently subsequently RB cord-326015-ky4y2xjt 149 14 appear appear VB cord-326015-ky4y2xjt 149 15 at at IN cord-326015-ky4y2xjt 149 16 ER ER NNP cord-326015-ky4y2xjt 149 17 exit exit NN cord-326015-ky4y2xjt 149 18 sites site NNS cord-326015-ky4y2xjt 149 19 . . . cord-326015-ky4y2xjt 150 1 Such such PDT cord-326015-ky4y2xjt 150 2 a a DT cord-326015-ky4y2xjt 150 3 recycling recycling NN cord-326015-ky4y2xjt 150 4 model model NN cord-326015-ky4y2xjt 150 5 has have VBZ cord-326015-ky4y2xjt 150 6 also also RB cord-326015-ky4y2xjt 150 7 been be VBN cord-326015-ky4y2xjt 150 8 proposed propose VBN cord-326015-ky4y2xjt 150 9 to to TO cord-326015-ky4y2xjt 150 10 explain explain VB cord-326015-ky4y2xjt 150 11 how how WRB cord-326015-ky4y2xjt 150 12 Golgi Golgi NNP cord-326015-ky4y2xjt 150 13 redistributes redistribute VBZ cord-326015-ky4y2xjt 150 14 upon upon IN cord-326015-ky4y2xjt 150 15 depolymerisation depolymerisation NN cord-326015-ky4y2xjt 150 16 of of IN cord-326015-ky4y2xjt 150 17 microtubules microtubule NNS cord-326015-ky4y2xjt 150 18 or or CC cord-326015-ky4y2xjt 150 19 mitosis mitosis NN cord-326015-ky4y2xjt 150 20 ( ( -LRB- cord-326015-ky4y2xjt 150 21 see see VB cord-326015-ky4y2xjt 150 22 above above RB cord-326015-ky4y2xjt 150 23 and and CC cord-326015-ky4y2xjt 150 24 Storrie Storrie NNP cord-326015-ky4y2xjt 150 25 and and CC cord-326015-ky4y2xjt 150 26 Yang Yang NNP cord-326015-ky4y2xjt 150 27 , , , cord-326015-ky4y2xjt 150 28 this this DT cord-326015-ky4y2xjt 150 29 issue issue NN cord-326015-ky4y2xjt 150 30 ) ) -RRB- cord-326015-ky4y2xjt 150 31 . . . cord-326015-ky4y2xjt 151 1 It -PRON- PRP cord-326015-ky4y2xjt 151 2 is be VBZ cord-326015-ky4y2xjt 151 3 di¤cult di¤cult NN cord-326015-ky4y2xjt 151 4 to to TO cord-326015-ky4y2xjt 151 5 envisage envisage VB cord-326015-ky4y2xjt 151 6 how how WRB cord-326015-ky4y2xjt 151 7 this this DT cord-326015-ky4y2xjt 151 8 could could MD cord-326015-ky4y2xjt 151 9 account account VB cord-326015-ky4y2xjt 151 10 for for IN cord-326015-ky4y2xjt 151 11 observed observed JJ cord-326015-ky4y2xjt 151 12 gradients gradient NNS cord-326015-ky4y2xjt 151 13 of of IN cord-326015-ky4y2xjt 151 14 late late JJ cord-326015-ky4y2xjt 151 15 glycosylation glycosylation NN cord-326015-ky4y2xjt 151 16 enzymes enzyme NNS cord-326015-ky4y2xjt 151 17 , , , cord-326015-ky4y2xjt 151 18 particularly particularly RB cord-326015-ky4y2xjt 151 19 in in IN cord-326015-ky4y2xjt 151 20 the the DT cord-326015-ky4y2xjt 151 21 context context NN cord-326015-ky4y2xjt 151 22 of of IN cord-326015-ky4y2xjt 151 23 cisternal cisternal JJ cord-326015-ky4y2xjt 151 24 maturation maturation NN cord-326015-ky4y2xjt 151 25 . . . cord-326015-ky4y2xjt 152 1 If if IN cord-326015-ky4y2xjt 152 2 the the DT cord-326015-ky4y2xjt 152 3 steady steady JJ cord-326015-ky4y2xjt 152 4 state state NN cord-326015-ky4y2xjt 152 5 distributions distribution NNS cord-326015-ky4y2xjt 152 6 of of IN cord-326015-ky4y2xjt 152 7 NAGT NAGT NNP cord-326015-ky4y2xjt 152 8 I I NNP cord-326015-ky4y2xjt 152 9 , , , cord-326015-ky4y2xjt 152 10 Mann Mann NNP cord-326015-ky4y2xjt 152 11 II II NNP cord-326015-ky4y2xjt 152 12 , , , cord-326015-ky4y2xjt 152 13 GalT GalT NNP cord-326015-ky4y2xjt 152 14 and and CC cord-326015-ky4y2xjt 152 15 SialylT SialylT NNP cord-326015-ky4y2xjt 152 16 are be VBP cord-326015-ky4y2xjt 152 17 the the DT cord-326015-ky4y2xjt 152 18 consequence consequence NN cord-326015-ky4y2xjt 152 19 of of IN cord-326015-ky4y2xjt 152 20 constant constant JJ cord-326015-ky4y2xjt 152 21 recycling recycling NN cord-326015-ky4y2xjt 152 22 through through IN cord-326015-ky4y2xjt 152 23 the the DT cord-326015-ky4y2xjt 152 24 ER ER NNP cord-326015-ky4y2xjt 152 25 , , , cord-326015-ky4y2xjt 152 26 their -PRON- PRP$ cord-326015-ky4y2xjt 152 27 distributions distribution NNS cord-326015-ky4y2xjt 152 28 would would MD cord-326015-ky4y2xjt 152 29 be be VB cord-326015-ky4y2xjt 152 30 expected expect VBN cord-326015-ky4y2xjt 152 31 to to TO cord-326015-ky4y2xjt 152 32 appear appear VB cord-326015-ky4y2xjt 152 33 £ £ $ cord-326015-ky4y2xjt 152 34 atter atter NN cord-326015-ky4y2xjt 152 35 than than IN cord-326015-ky4y2xjt 152 36 their -PRON- PRP$ cord-326015-ky4y2xjt 152 37 observed observed JJ cord-326015-ky4y2xjt 152 38 sharp sharp JJ cord-326015-ky4y2xjt 152 39 gradients gradient NNS cord-326015-ky4y2xjt 152 40 . . . cord-326015-ky4y2xjt 153 1 Moreover moreover RB cord-326015-ky4y2xjt 153 2 , , , cord-326015-ky4y2xjt 153 3 if if IN cord-326015-ky4y2xjt 153 4 glycosylation glycosylation NN cord-326015-ky4y2xjt 153 5 enzymes enzyme NNS cord-326015-ky4y2xjt 153 6 were be VBD cord-326015-ky4y2xjt 153 7 to to TO cord-326015-ky4y2xjt 153 8 travel travel VB cord-326015-ky4y2xjt 153 9 through through IN cord-326015-ky4y2xjt 153 10 the the DT cord-326015-ky4y2xjt 153 11 ER ER NNP cord-326015-ky4y2xjt 153 12 , , , cord-326015-ky4y2xjt 153 13 unless unless IN cord-326015-ky4y2xjt 153 14 they -PRON- PRP cord-326015-ky4y2xjt 153 15 were be VBD cord-326015-ky4y2xjt 153 16 inactive inactive JJ cord-326015-ky4y2xjt 153 17 , , , cord-326015-ky4y2xjt 153 18 they -PRON- PRP cord-326015-ky4y2xjt 153 19 would would MD cord-326015-ky4y2xjt 153 20 act act VB cord-326015-ky4y2xjt 153 21 on on IN cord-326015-ky4y2xjt 153 22 ER ER NNP cord-326015-ky4y2xjt 153 23 resident resident NN cord-326015-ky4y2xjt 153 24 glycoproteins glycoprotein NNS cord-326015-ky4y2xjt 153 25 . . . cord-326015-ky4y2xjt 154 1 As as IN cord-326015-ky4y2xjt 154 2 this this DT cord-326015-ky4y2xjt 154 3 appears appear VBZ cord-326015-ky4y2xjt 154 4 not not RB cord-326015-ky4y2xjt 154 5 to to TO cord-326015-ky4y2xjt 154 6 be be VB cord-326015-ky4y2xjt 154 7 the the DT cord-326015-ky4y2xjt 154 8 case case NN cord-326015-ky4y2xjt 154 9 , , , cord-326015-ky4y2xjt 154 10 it -PRON- PRP cord-326015-ky4y2xjt 154 11 is be VBZ cord-326015-ky4y2xjt 154 12 hard hard JJ cord-326015-ky4y2xjt 154 13 to to TO cord-326015-ky4y2xjt 154 14 reconcile reconcile VB cord-326015-ky4y2xjt 154 15 this this DT cord-326015-ky4y2xjt 154 16 with with IN cord-326015-ky4y2xjt 154 17 a a DT cord-326015-ky4y2xjt 154 18 continuous continuous JJ cord-326015-ky4y2xjt 154 19 £ £ NN cord-326015-ky4y2xjt 154 20 ow ow NN cord-326015-ky4y2xjt 154 21 of of IN cord-326015-ky4y2xjt 154 22 late late JJ cord-326015-ky4y2xjt 154 23 Golgi Golgi NNP cord-326015-ky4y2xjt 154 24 residents resident NNS cord-326015-ky4y2xjt 154 25 through through IN cord-326015-ky4y2xjt 154 26 the the DT cord-326015-ky4y2xjt 154 27 ER ER NNP cord-326015-ky4y2xjt 154 28 [ [ -LRB- cord-326015-ky4y2xjt 154 29 59 59 CD cord-326015-ky4y2xjt 154 30 ] ] -RRB- cord-326015-ky4y2xjt 154 31 . . . cord-326015-ky4y2xjt 155 1 In in IN cord-326015-ky4y2xjt 155 2 summary summary NN cord-326015-ky4y2xjt 155 3 , , , cord-326015-ky4y2xjt 155 4 we -PRON- PRP cord-326015-ky4y2xjt 155 5 favour favour VBP cord-326015-ky4y2xjt 155 6 the the DT cord-326015-ky4y2xjt 155 7 model model NN cord-326015-ky4y2xjt 155 8 that that IN cord-326015-ky4y2xjt 155 9 steady steady JJ cord-326015-ky4y2xjt 155 10 state state NN cord-326015-ky4y2xjt 155 11 distribution distribution NN cord-326015-ky4y2xjt 155 12 of of IN cord-326015-ky4y2xjt 155 13 resident resident JJ cord-326015-ky4y2xjt 155 14 proteins protein NNS cord-326015-ky4y2xjt 155 15 along along IN cord-326015-ky4y2xjt 155 16 the the DT cord-326015-ky4y2xjt 155 17 exocytic exocytic JJ cord-326015-ky4y2xjt 155 18 pathway pathway NN cord-326015-ky4y2xjt 155 19 relies rely VBZ cord-326015-ky4y2xjt 155 20 on on IN cord-326015-ky4y2xjt 155 21 a a DT cord-326015-ky4y2xjt 155 22 combination combination NN cord-326015-ky4y2xjt 155 23 of of IN cord-326015-ky4y2xjt 155 24 oligomerisation oligomerisation NN cord-326015-ky4y2xjt 155 25 and and CC cord-326015-ky4y2xjt 155 26 coat coat NN cord-326015-ky4y2xjt 155 27 binding bind VBG cord-326015-ky4y2xjt 155 28 . . . cord-326015-ky4y2xjt 156 1 This this DT cord-326015-ky4y2xjt 156 2 allows allow VBZ cord-326015-ky4y2xjt 156 3 for for IN cord-326015-ky4y2xjt 156 4 a a DT cord-326015-ky4y2xjt 156 5 machinery machinery NN cord-326015-ky4y2xjt 156 6 maintaining maintain VBG cord-326015-ky4y2xjt 156 7 residents resident NNS cord-326015-ky4y2xjt 156 8 at at IN cord-326015-ky4y2xjt 156 9 various various JJ cord-326015-ky4y2xjt 156 10 levels level NNS cord-326015-ky4y2xjt 156 11 of of IN cord-326015-ky4y2xjt 156 12 the the DT cord-326015-ky4y2xjt 156 13 pathway pathway NN cord-326015-ky4y2xjt 156 14 whilst whilst IN cord-326015-ky4y2xjt 156 15 moving move VBG cord-326015-ky4y2xjt 156 16 cargo cargo NN cord-326015-ky4y2xjt 156 17 forward forward RB cord-326015-ky4y2xjt 156 18 in in IN cord-326015-ky4y2xjt 156 19 a a DT cord-326015-ky4y2xjt 156 20 vectorial vectorial JJ cord-326015-ky4y2xjt 156 21 manner manner NN cord-326015-ky4y2xjt 156 22 . . . cord-326015-ky4y2xjt 157 1 International International NNP cord-326015-ky4y2xjt 157 2 Cell Cell NNP cord-326015-ky4y2xjt 157 3 Biology Biology NNP cord-326015-ky4y2xjt 157 4 Protein Protein NNP cord-326015-ky4y2xjt 157 5 sorting sorting NN cord-326015-ky4y2xjt 157 6 by by IN cord-326015-ky4y2xjt 157 7 transport transport NN cord-326015-ky4y2xjt 157 8 vesicles vesicle NNS cord-326015-ky4y2xjt 157 9 Coat coat NN cord-326015-ky4y2xjt 157 10 proteins protein NNS cord-326015-ky4y2xjt 157 11 and and CC cord-326015-ky4y2xjt 157 12 vesicle vesicle NN cord-326015-ky4y2xjt 157 13 budding bud VBG cord-326015-ky4y2xjt 157 14 Scale scale NN cord-326015-ky4y2xjt 157 15 formation formation NN cord-326015-ky4y2xjt 157 16 in in IN cord-326015-ky4y2xjt 157 17 algae algae NN cord-326015-ky4y2xjt 157 18 Three three CD cord-326015-ky4y2xjt 157 19 - - HYPH cord-326015-ky4y2xjt 157 20 dimensional dimensional JJ cord-326015-ky4y2xjt 157 21 electron electron NN cord-326015-ky4y2xjt 157 22 microscopy microscopy NN cord-326015-ky4y2xjt 157 23 : : : cord-326015-ky4y2xjt 157 24 Structure structure NN cord-326015-ky4y2xjt 157 25 of of IN cord-326015-ky4y2xjt 157 26 the the DT cord-326015-ky4y2xjt 157 27 Golgi Golgi NNP cord-326015-ky4y2xjt 157 28 apparatus apparatus NN cord-326015-ky4y2xjt 158 1 The the DT cord-326015-ky4y2xjt 158 2 Cell cell NN cord-326015-ky4y2xjt 158 3 ( ( -LRB- cord-326015-ky4y2xjt 158 4 2nd 2nd JJ cord-326015-ky4y2xjt 158 5 Edn Edn NNP cord-326015-ky4y2xjt 158 6 Progress Progress NNP cord-326015-ky4y2xjt 158 7 in in IN cord-326015-ky4y2xjt 158 8 unraveling unravel VBG cord-326015-ky4y2xjt 158 9 pathways pathway NNS cord-326015-ky4y2xjt 158 10 of of IN cord-326015-ky4y2xjt 158 11 Golgi Golgi NNP cord-326015-ky4y2xjt 158 12 tra¤c tra¤c NNP cord-326015-ky4y2xjt 159 1 A a DT cord-326015-ky4y2xjt 159 2 protein protein NN cord-326015-ky4y2xjt 159 3 component component NN cord-326015-ky4y2xjt 159 4 of of IN cord-326015-ky4y2xjt 159 5 the the DT cord-326015-ky4y2xjt 159 6 Golgi Golgi NNP cord-326015-ky4y2xjt 159 7 apparatus apparatus NN cord-326015-ky4y2xjt 159 8 Distribution distribution NN cord-326015-ky4y2xjt 159 9 of of IN cord-326015-ky4y2xjt 159 10 periodic periodic JJ cord-326015-ky4y2xjt 159 11 acid acid NN cord-326015-ky4y2xjt 159 12 - - HYPH cord-326015-ky4y2xjt 159 13 reactive reactive JJ cord-326015-ky4y2xjt 159 14 carbohydrates carbohydrate NNS cord-326015-ky4y2xjt 159 15 in in IN cord-326015-ky4y2xjt 159 16 the the DT cord-326015-ky4y2xjt 159 17 adult adult NN cord-326015-ky4y2xjt 159 18 rat rat NN cord-326015-ky4y2xjt 160 1 Early early JJ cord-326015-ky4y2xjt 160 2 and and CC cord-326015-ky4y2xjt 160 3 late late JJ cord-326015-ky4y2xjt 160 4 functions function NNS cord-326015-ky4y2xjt 160 5 associated associate VBN cord-326015-ky4y2xjt 160 6 with with IN cord-326015-ky4y2xjt 160 7 the the DT cord-326015-ky4y2xjt 160 8 Golgi Golgi NNP cord-326015-ky4y2xjt 160 9 apparatus apparatus NN cord-326015-ky4y2xjt 160 10 reside reside VBP cord-326015-ky4y2xjt 160 11 in in IN cord-326015-ky4y2xjt 160 12 distinct distinct JJ cord-326015-ky4y2xjt 160 13 compartments compartment NNS cord-326015-ky4y2xjt 160 14 Compartmentation compartmentation NN cord-326015-ky4y2xjt 160 15 of of IN cord-326015-ky4y2xjt 160 16 asparagine asparagine NN cord-326015-ky4y2xjt 160 17 - - HYPH cord-326015-ky4y2xjt 160 18 linked link VBN cord-326015-ky4y2xjt 160 19 oligosaccharide oligosaccharide NN cord-326015-ky4y2xjt 160 20 processing processing NN cord-326015-ky4y2xjt 160 21 in in IN cord-326015-ky4y2xjt 160 22 the the DT cord-326015-ky4y2xjt 160 23 Golgi Golgi NNP cord-326015-ky4y2xjt 160 24 apparatus apparatus NN cord-326015-ky4y2xjt 160 25 Subcellular Subcellular NNP cord-326015-ky4y2xjt 160 26 organization organization NN cord-326015-ky4y2xjt 160 27 of of IN cord-326015-ky4y2xjt 160 28 glycosylation glycosylation NN cord-326015-ky4y2xjt 160 29 in in IN cord-326015-ky4y2xjt 160 30 mammalian mammalian JJ cord-326015-ky4y2xjt 160 31 cells cell NNS cord-326015-ky4y2xjt 161 1 Immunocytochemical Immunocytochemical NNP cord-326015-ky4y2xjt 161 2 localization localization NN cord-326015-ky4y2xjt 161 3 of of IN cord-326015-ky4y2xjt 161 4 galactosyltransferase galactosyltransferase NN cord-326015-ky4y2xjt 161 5 in in IN cord-326015-ky4y2xjt 161 6 HeLa HeLa NNP cord-326015-ky4y2xjt 161 7 cells cell NNS cord-326015-ky4y2xjt 161 8 : : : cord-326015-ky4y2xjt 162 1 codistribution codistribution NN cord-326015-ky4y2xjt 162 2 with with IN cord-326015-ky4y2xjt 162 3 thiamine thiamine NN cord-326015-ky4y2xjt 162 4 pyrophosphatase pyrophosphatase NN cord-326015-ky4y2xjt 162 5 in in IN cord-326015-ky4y2xjt 162 6 trans trans NNP cord-326015-ky4y2xjt 162 7 - - NNP cord-326015-ky4y2xjt 162 8 Golgi Golgi NNP cord-326015-ky4y2xjt 162 9 cisternae cisternae NNP cord-326015-ky4y2xjt 162 10 Paulson Paulson NNP cord-326015-ky4y2xjt 162 11 , , , cord-326015-ky4y2xjt 162 12 Demonstration Demonstration NNP cord-326015-ky4y2xjt 162 13 of of IN cord-326015-ky4y2xjt 162 14 an an DT cord-326015-ky4y2xjt 162 15 extensive extensive JJ cord-326015-ky4y2xjt 162 16 trans trans JJ cord-326015-ky4y2xjt 162 17 - - JJ cord-326015-ky4y2xjt 162 18 tubular tubular JJ cord-326015-ky4y2xjt 162 19 network network NN cord-326015-ky4y2xjt 162 20 continuous continuous JJ cord-326015-ky4y2xjt 162 21 with with IN cord-326015-ky4y2xjt 162 22 the the DT cord-326015-ky4y2xjt 162 23 Golgi Golgi NNP cord-326015-ky4y2xjt 162 24 apparatus apparatus NN cord-326015-ky4y2xjt 162 25 stack stack NN cord-326015-ky4y2xjt 162 26 that that WDT cord-326015-ky4y2xjt 162 27 may may MD cord-326015-ky4y2xjt 162 28 function function VB cord-326015-ky4y2xjt 162 29 in in IN cord-326015-ky4y2xjt 162 30 glycosylation glycosylation NN cord-326015-ky4y2xjt 162 31 Attachment attachment NN cord-326015-ky4y2xjt 162 32 of of IN cord-326015-ky4y2xjt 162 33 terminal terminal JJ cord-326015-ky4y2xjt 162 34 N n CD cord-326015-ky4y2xjt 162 35 - - HYPH cord-326015-ky4y2xjt 162 36 acetylglucosamine acetylglucosamine NNP cord-326015-ky4y2xjt 162 37 to to IN cord-326015-ky4y2xjt 162 38 asparagine asparagine NN cord-326015-ky4y2xjt 162 39 - - HYPH cord-326015-ky4y2xjt 162 40 linked link VBN cord-326015-ky4y2xjt 162 41 oligosaccharides oligosaccharide NNS cord-326015-ky4y2xjt 162 42 occurs occur VBZ cord-326015-ky4y2xjt 162 43 in in IN cord-326015-ky4y2xjt 162 44 central central JJ cord-326015-ky4y2xjt 162 45 cisternae cisternae NN cord-326015-ky4y2xjt 162 46 of of IN cord-326015-ky4y2xjt 162 47 the the DT cord-326015-ky4y2xjt 162 48 Golgi Golgi NNP cord-326015-ky4y2xjt 162 49 stack stack NN cord-326015-ky4y2xjt 162 50 Cell cell NN cord-326015-ky4y2xjt 162 51 type type NN cord-326015-ky4y2xjt 162 52 - - HYPH cord-326015-ky4y2xjt 162 53 dependent dependent JJ cord-326015-ky4y2xjt 162 54 variations variation NNS cord-326015-ky4y2xjt 162 55 in in IN cord-326015-ky4y2xjt 162 56 the the DT cord-326015-ky4y2xjt 162 57 subcellular subcellular JJ cord-326015-ky4y2xjt 162 58 distribution distribution NN cord-326015-ky4y2xjt 162 59 of of IN cord-326015-ky4y2xjt 162 60 alpha alpha NN cord-326015-ky4y2xjt 162 61 - - HYPH cord-326015-ky4y2xjt 162 62 mannosidase mannosidase NN cord-326015-ky4y2xjt 162 63 I I NNP cord-326015-ky4y2xjt 162 64 and and CC cord-326015-ky4y2xjt 162 65 II II NNP cord-326015-ky4y2xjt 162 66 Overlapping Overlapping NNP cord-326015-ky4y2xjt 162 67 distribution distribution NN cord-326015-ky4y2xjt 162 68 of of IN cord-326015-ky4y2xjt 162 69 two two CD cord-326015-ky4y2xjt 162 70 glycosyltransferases glycosyltransferase NNS cord-326015-ky4y2xjt 162 71 in in IN cord-326015-ky4y2xjt 162 72 the the DT cord-326015-ky4y2xjt 162 73 Golgi Golgi NNP cord-326015-ky4y2xjt 162 74 apparatus apparatus NN cord-326015-ky4y2xjt 162 75 of of IN cord-326015-ky4y2xjt 162 76 HeLa HeLa NNP cord-326015-ky4y2xjt 162 77 cells cell NNS cord-326015-ky4y2xjt 162 78 Mapping map VBG cord-326015-ky4y2xjt 162 79 the the DT cord-326015-ky4y2xjt 162 80 distribution distribution NN cord-326015-ky4y2xjt 162 81 of of IN cord-326015-ky4y2xjt 162 82 Golgi Golgi NNP cord-326015-ky4y2xjt 162 83 enzymes enzyme NNS cord-326015-ky4y2xjt 162 84 involved involve VBN cord-326015-ky4y2xjt 162 85 in in IN cord-326015-ky4y2xjt 162 86 the the DT cord-326015-ky4y2xjt 162 87 construction construction NN cord-326015-ky4y2xjt 162 88 of of IN cord-326015-ky4y2xjt 162 89 complex complex JJ cord-326015-ky4y2xjt 162 90 oligosaccharides oligosaccharide NNS cord-326015-ky4y2xjt 162 91 Localization Localization NNP cord-326015-ky4y2xjt 162 92 of of IN cord-326015-ky4y2xjt 162 93 three three CD cord-326015-ky4y2xjt 162 94 human human JJ cord-326015-ky4y2xjt 162 95 polypeptide polypeptide NN cord-326015-ky4y2xjt 163 1 GalNActransferases GalNActransferases NNP cord-326015-ky4y2xjt 163 2 in in IN cord-326015-ky4y2xjt 163 3 HeLa HeLa NNP cord-326015-ky4y2xjt 163 4 cells cell NNS cord-326015-ky4y2xjt 163 5 suggests suggest VBZ cord-326015-ky4y2xjt 163 6 initiation initiation NN cord-326015-ky4y2xjt 163 7 of of IN cord-326015-ky4y2xjt 163 8 O o NN cord-326015-ky4y2xjt 163 9 - - HYPH cord-326015-ky4y2xjt 163 10 linked link VBN cord-326015-ky4y2xjt 163 11 glycosylation glycosylation NN cord-326015-ky4y2xjt 163 12 throughout throughout IN cord-326015-ky4y2xjt 163 13 the the DT cord-326015-ky4y2xjt 163 14 Golgi Golgi NNP cord-326015-ky4y2xjt 163 15 apparatus apparatus NN cord-326015-ky4y2xjt 164 1 A a DT cord-326015-ky4y2xjt 164 2 cisternal cisternal JJ cord-326015-ky4y2xjt 164 3 maturation maturation NN cord-326015-ky4y2xjt 164 4 mechanism mechanism NN cord-326015-ky4y2xjt 164 5 can can MD cord-326015-ky4y2xjt 164 6 explain explain VB cord-326015-ky4y2xjt 164 7 the the DT cord-326015-ky4y2xjt 164 8 asymmetry asymmetry NN cord-326015-ky4y2xjt 164 9 of of IN cord-326015-ky4y2xjt 164 10 the the DT cord-326015-ky4y2xjt 164 11 Golgi Golgi NNP cord-326015-ky4y2xjt 164 12 stack stack NN cord-326015-ky4y2xjt 164 13 Targeting targeting NN cord-326015-ky4y2xjt 164 14 and and CC cord-326015-ky4y2xjt 164 15 retention retention NN cord-326015-ky4y2xjt 164 16 of of IN cord-326015-ky4y2xjt 164 17 Golgi Golgi NNP cord-326015-ky4y2xjt 164 18 membrane membrane NN cord-326015-ky4y2xjt 164 19 proteins protein NNS cord-326015-ky4y2xjt 164 20 Golgi Golgi NNP cord-326015-ky4y2xjt 164 21 localization localization NN cord-326015-ky4y2xjt 164 22 of of IN cord-326015-ky4y2xjt 164 23 glycosyltransferases glycosyltransferase NNS cord-326015-ky4y2xjt 164 24 : : : cord-326015-ky4y2xjt 164 25 more more JJR cord-326015-ky4y2xjt 164 26 questions question NNS cord-326015-ky4y2xjt 164 27 than than IN cord-326015-ky4y2xjt 164 28 answers answer NNS cord-326015-ky4y2xjt 164 29 Cholesterol cholesterol NN cord-326015-ky4y2xjt 164 30 and and CC cord-326015-ky4y2xjt 164 31 the the DT cord-326015-ky4y2xjt 164 32 Golgi Golgi NNP cord-326015-ky4y2xjt 164 33 apparatus apparatus NN cord-326015-ky4y2xjt 164 34 Sequences Sequences NNPS cord-326015-ky4y2xjt 164 35 within within IN cord-326015-ky4y2xjt 164 36 and and CC cord-326015-ky4y2xjt 164 37 adjacent adjacent JJ cord-326015-ky4y2xjt 164 38 to to IN cord-326015-ky4y2xjt 164 39 the the DT cord-326015-ky4y2xjt 164 40 transmembrane transmembrane NN cord-326015-ky4y2xjt 164 41 segment segment NN cord-326015-ky4y2xjt 164 42 of of IN cord-326015-ky4y2xjt 164 43 K-2,6-sialyltransferase K-2,6-sialyltransferase NNP cord-326015-ky4y2xjt 164 44 specify specify VB cord-326015-ky4y2xjt 165 1 Golgi Golgi NNP cord-326015-ky4y2xjt 165 2 retention retention NN cord-326015-ky4y2xjt 165 3 An an DT cord-326015-ky4y2xjt 165 4 investigation investigation NN cord-326015-ky4y2xjt 165 5 of of IN cord-326015-ky4y2xjt 165 6 the the DT cord-326015-ky4y2xjt 165 7 role role NN cord-326015-ky4y2xjt 165 8 of of IN cord-326015-ky4y2xjt 165 9 transmembrane transmembrane NN cord-326015-ky4y2xjt 165 10 domains domain NNS cord-326015-ky4y2xjt 165 11 in in IN cord-326015-ky4y2xjt 165 12 Golgi Golgi NNP cord-326015-ky4y2xjt 165 13 protein protein NN cord-326015-ky4y2xjt 165 14 retention retention NN cord-326015-ky4y2xjt 165 15 Heterogeneous heterogeneous JJ cord-326015-ky4y2xjt 165 16 distribution distribution NN cord-326015-ky4y2xjt 165 17 of of IN cord-326015-ky4y2xjt 165 18 ¢lipin^cholesterol ¢lipin^cholesterol NN cord-326015-ky4y2xjt 165 19 complexes complex NNS cord-326015-ky4y2xjt 165 20 across across IN cord-326015-ky4y2xjt 165 21 the the DT cord-326015-ky4y2xjt 165 22 cisternae cisternae NN cord-326015-ky4y2xjt 165 23 of of IN cord-326015-ky4y2xjt 165 24 the the DT cord-326015-ky4y2xjt 165 25 Golgi Golgi NNP cord-326015-ky4y2xjt 165 26 apparatus apparatus NN cord-326015-ky4y2xjt 165 27 Membrane Membrane NNP cord-326015-ky4y2xjt 165 28 Protein Protein NNP cord-326015-ky4y2xjt 165 29 Assembly Assembly NNP cord-326015-ky4y2xjt 166 1 The the DT cord-326015-ky4y2xjt 166 2 membrane membrane NN cord-326015-ky4y2xjt 166 3 spanning span VBG cord-326015-ky4y2xjt 166 4 domain domain NN cord-326015-ky4y2xjt 166 5 of of IN cord-326015-ky4y2xjt 166 6 L-1,4-galactosyltransferase L-1,4-galactosyltransferase NNP cord-326015-ky4y2xjt 167 1 speci-¢es speci-¢es -LRB- cord-326015-ky4y2xjt 167 2 trans trans NNP cord-326015-ky4y2xjt 167 3 Golgi Golgi NNP cord-326015-ky4y2xjt 167 4 localization localization NN cord-326015-ky4y2xjt 167 5 A a DT cord-326015-ky4y2xjt 167 6 Golgi Golgi NNP cord-326015-ky4y2xjt 167 7 retention retention NN cord-326015-ky4y2xjt 167 8 signal signal NN cord-326015-ky4y2xjt 167 9 in in IN cord-326015-ky4y2xjt 167 10 a a DT cord-326015-ky4y2xjt 167 11 membrane membrane NN cord-326015-ky4y2xjt 167 12 - - HYPH cord-326015-ky4y2xjt 167 13 spanning span VBG cord-326015-ky4y2xjt 167 14 domain domain NN cord-326015-ky4y2xjt 167 15 of of IN cord-326015-ky4y2xjt 167 16 coronavirus coronavirus NN cord-326015-ky4y2xjt 167 17 E1 e1 NN cord-326015-ky4y2xjt 167 18 protein protein NN cord-326015-ky4y2xjt 167 19 Oligomerization Oligomerization NNP cord-326015-ky4y2xjt 167 20 of of IN cord-326015-ky4y2xjt 167 21 a a DT cord-326015-ky4y2xjt 167 22 membrane membrane NN cord-326015-ky4y2xjt 167 23 protein protein NN cord-326015-ky4y2xjt 167 24 correlates correlate VBZ cord-326015-ky4y2xjt 167 25 with with IN cord-326015-ky4y2xjt 167 26 its -PRON- PRP$ cord-326015-ky4y2xjt 167 27 retention retention NN cord-326015-ky4y2xjt 167 28 in in IN cord-326015-ky4y2xjt 167 29 the the DT cord-326015-ky4y2xjt 167 30 Golgi Golgi NNP cord-326015-ky4y2xjt 167 31 complex complex JJ cord-326015-ky4y2xjt 167 32 Retention Retention NNP cord-326015-ky4y2xjt 167 33 of of IN cord-326015-ky4y2xjt 167 34 a a DT cord-326015-ky4y2xjt 167 35 cis cis NNP cord-326015-ky4y2xjt 167 36 Golgi Golgi NNP cord-326015-ky4y2xjt 167 37 protein protein NN cord-326015-ky4y2xjt 168 1 requires require VBZ cord-326015-ky4y2xjt 168 2 polar polar JJ cord-326015-ky4y2xjt 168 3 residues residue NNS cord-326015-ky4y2xjt 168 4 on on IN cord-326015-ky4y2xjt 168 5 one one CD cord-326015-ky4y2xjt 168 6 face face NN cord-326015-ky4y2xjt 168 7 of of IN cord-326015-ky4y2xjt 168 8 a a DT cord-326015-ky4y2xjt 168 9 predicted predict VBN cord-326015-ky4y2xjt 168 10 K k NN cord-326015-ky4y2xjt 168 11 - - HYPH cord-326015-ky4y2xjt 168 12 helix helix NN cord-326015-ky4y2xjt 168 13 in in IN cord-326015-ky4y2xjt 168 14 the the DT cord-326015-ky4y2xjt 168 15 transmembrane transmembrane NN cord-326015-ky4y2xjt 168 16 domain domain NN cord-326015-ky4y2xjt 168 17 Isolation isolation NN cord-326015-ky4y2xjt 168 18 of of IN cord-326015-ky4y2xjt 168 19 a a DT cord-326015-ky4y2xjt 168 20 matrix matrix NN cord-326015-ky4y2xjt 168 21 that that WDT cord-326015-ky4y2xjt 168 22 binds bind VBZ cord-326015-ky4y2xjt 168 23 medial medial JJ cord-326015-ky4y2xjt 168 24 Golgi Golgi NNP cord-326015-ky4y2xjt 168 25 enzymes enzyme NNS cord-326015-ky4y2xjt 168 26 Nilsson Nilsson NNP cord-326015-ky4y2xjt 168 27 , , , cord-326015-ky4y2xjt 168 28 gp25L gp25l NN cord-326015-ky4y2xjt 168 29 / / SYM cord-326015-ky4y2xjt 168 30 emp24 emp24 CD cord-326015-ky4y2xjt 168 31 / / SYM cord-326015-ky4y2xjt 168 32 p24 p24 NN cord-326015-ky4y2xjt 168 33 protein protein NN cord-326015-ky4y2xjt 168 34 family family NN cord-326015-ky4y2xjt 168 35 members member NNS cord-326015-ky4y2xjt 168 36 of of IN cord-326015-ky4y2xjt 168 37 the the DT cord-326015-ky4y2xjt 168 38 cis cis NNP cord-326015-ky4y2xjt 168 39 Golgi Golgi NNP cord-326015-ky4y2xjt 168 40 network network NN cord-326015-ky4y2xjt 169 1 bind bind VB cord-326015-ky4y2xjt 169 2 both both DT cord-326015-ky4y2xjt 169 3 COP cop NN cord-326015-ky4y2xjt 169 4 I I NNP cord-326015-ky4y2xjt 169 5 and and CC cord-326015-ky4y2xjt 169 6 II II NNP cord-326015-ky4y2xjt 169 7 coatomer coatomer NNP cord-326015-ky4y2xjt 169 8 Post Post NNP cord-326015-ky4y2xjt 169 9 - - JJ cord-326015-ky4y2xjt 169 10 translational translational JJ cord-326015-ky4y2xjt 169 11 modi¢cations modi¢cation NNS cord-326015-ky4y2xjt 169 12 distinguish distinguish VBP cord-326015-ky4y2xjt 169 13 cell cell NN cord-326015-ky4y2xjt 169 14 surface surface NN cord-326015-ky4y2xjt 169 15 from from IN cord-326015-ky4y2xjt 169 16 Golgi Golgi NNP cord-326015-ky4y2xjt 169 17 - - HYPH cord-326015-ky4y2xjt 169 18 retained retain VBN cord-326015-ky4y2xjt 169 19 L1,4 l1,4 NN cord-326015-ky4y2xjt 169 20 galactosyltransferase galactosyltransferase NN cord-326015-ky4y2xjt 169 21 molecules molecule NNS cord-326015-ky4y2xjt 169 22 . . . cord-326015-ky4y2xjt 170 1 Golgi Golgi NNP cord-326015-ky4y2xjt 170 2 localization localization NN cord-326015-ky4y2xjt 170 3 involves involve VBZ cord-326015-ky4y2xjt 170 4 active active JJ cord-326015-ky4y2xjt 170 5 retention retention NN cord-326015-ky4y2xjt 170 6 Kinrecognition Kinrecognition NNP cord-326015-ky4y2xjt 170 7 between between IN cord-326015-ky4y2xjt 170 8 medial medial JJ cord-326015-ky4y2xjt 170 9 Golgi Golgi NNP cord-326015-ky4y2xjt 170 10 enzymes enzyme NNS cord-326015-ky4y2xjt 170 11 in in IN cord-326015-ky4y2xjt 170 12 HeLa HeLa NNP cord-326015-ky4y2xjt 170 13 cells cell NNS cord-326015-ky4y2xjt 171 1 The the DT cord-326015-ky4y2xjt 171 2 role role NN cord-326015-ky4y2xjt 171 3 of of IN cord-326015-ky4y2xjt 171 4 the the DT cord-326015-ky4y2xjt 171 5 membrane membrane NN cord-326015-ky4y2xjt 171 6 - - HYPH cord-326015-ky4y2xjt 171 7 spanning span VBG cord-326015-ky4y2xjt 171 8 domain domain NN cord-326015-ky4y2xjt 171 9 and and CC cord-326015-ky4y2xjt 171 10 stalk stalk VB cord-326015-ky4y2xjt 171 11 region region NN cord-326015-ky4y2xjt 171 12 of of IN cord-326015-ky4y2xjt 171 13 N n CD cord-326015-ky4y2xjt 172 1 acetylglucosaminyltransferase acetylglucosaminyltransferase NNP cord-326015-ky4y2xjt 173 1 I -PRON- PRP cord-326015-ky4y2xjt 173 2 in in IN cord-326015-ky4y2xjt 173 3 kin kin NNP cord-326015-ky4y2xjt 173 4 retention retention NNP cord-326015-ky4y2xjt 173 5 , , , cord-326015-ky4y2xjt 173 6 kin kin NN cord-326015-ky4y2xjt 173 7 recognition recognition NN cord-326015-ky4y2xjt 173 8 and and CC cord-326015-ky4y2xjt 173 9 structural structural JJ cord-326015-ky4y2xjt 173 10 maintainence maintainence NN cord-326015-ky4y2xjt 173 11 of of IN cord-326015-ky4y2xjt 173 12 the the DT cord-326015-ky4y2xjt 173 13 Golgi Golgi NNP cord-326015-ky4y2xjt 173 14 apparatus apparatus NN cord-326015-ky4y2xjt 173 15 in in IN cord-326015-ky4y2xjt 173 16 HeLa HeLa NNP cord-326015-ky4y2xjt 173 17 cells cell NNS cord-326015-ky4y2xjt 173 18 Erv25p Erv25p NNP cord-326015-ky4y2xjt 173 19 , , , cord-326015-ky4y2xjt 173 20 a a DT cord-326015-ky4y2xjt 173 21 component component NN cord-326015-ky4y2xjt 173 22 of of IN cord-326015-ky4y2xjt 173 23 COP cop NN cord-326015-ky4y2xjt 173 24 IIcoated iicoate VBN cord-326015-ky4y2xjt 173 25 vesicles vesicle NNS cord-326015-ky4y2xjt 173 26 , , , cord-326015-ky4y2xjt 173 27 forms form VBZ cord-326015-ky4y2xjt 173 28 a a DT cord-326015-ky4y2xjt 173 29 complex complex NN cord-326015-ky4y2xjt 173 30 with with IN cord-326015-ky4y2xjt 173 31 emp24p emp24p NNPS cord-326015-ky4y2xjt 173 32 that that WDT cord-326015-ky4y2xjt 173 33 is be VBZ cord-326015-ky4y2xjt 173 34 required require VBN cord-326015-ky4y2xjt 173 35 for for IN cord-326015-ky4y2xjt 173 36 e¤cient e¤cient NNP cord-326015-ky4y2xjt 173 37 endoplasmic endoplasmic NN cord-326015-ky4y2xjt 173 38 reticulum reticulum NN cord-326015-ky4y2xjt 173 39 to to IN cord-326015-ky4y2xjt 173 40 Golgi Golgi NNP cord-326015-ky4y2xjt 173 41 transport transport NN cord-326015-ky4y2xjt 174 1 The the DT cord-326015-ky4y2xjt 174 2 Golgi Golgi NNP cord-326015-ky4y2xjt 174 3 apparatus apparatus NN cord-326015-ky4y2xjt 174 4 : : : cord-326015-ky4y2xjt 174 5 two two CD cord-326015-ky4y2xjt 174 6 organelles organelle NNS cord-326015-ky4y2xjt 174 7 in in IN cord-326015-ky4y2xjt 174 8 tandem tandem NN cord-326015-ky4y2xjt 175 1 A a DT cord-326015-ky4y2xjt 175 2 C c NN cord-326015-ky4y2xjt 175 3 - - HYPH cord-326015-ky4y2xjt 175 4 terminal terminal NN cord-326015-ky4y2xjt 175 5 signal signal NN cord-326015-ky4y2xjt 175 6 prevents prevent VBZ cord-326015-ky4y2xjt 175 7 secretion secretion NN cord-326015-ky4y2xjt 175 8 of of IN cord-326015-ky4y2xjt 175 9 luminal luminal JJ cord-326015-ky4y2xjt 175 10 ER er NN cord-326015-ky4y2xjt 175 11 proteins protein NNS cord-326015-ky4y2xjt 176 1 Short short JJ cord-326015-ky4y2xjt 176 2 cytoplasmic cytoplasmic JJ cord-326015-ky4y2xjt 176 3 sequences sequence NNS cord-326015-ky4y2xjt 176 4 serve serve VBP cord-326015-ky4y2xjt 176 5 as as IN cord-326015-ky4y2xjt 176 6 retention retention NN cord-326015-ky4y2xjt 176 7 signals signal NNS cord-326015-ky4y2xjt 176 8 for for IN cord-326015-ky4y2xjt 176 9 transmembrane transmembrane NN cord-326015-ky4y2xjt 176 10 proteins protein NNS cord-326015-ky4y2xjt 176 11 in in IN cord-326015-ky4y2xjt 176 12 the the DT cord-326015-ky4y2xjt 176 13 endoplasmic endoplasmic NN cord-326015-ky4y2xjt 176 14 reticulum reticulum NN cord-326015-ky4y2xjt 176 15 Identi¢cation Identi¢cation NNP cord-326015-ky4y2xjt 176 16 of of IN cord-326015-ky4y2xjt 176 17 a a DT cord-326015-ky4y2xjt 176 18 consensus consensus NN cord-326015-ky4y2xjt 176 19 motif motif NN cord-326015-ky4y2xjt 176 20 for for IN cord-326015-ky4y2xjt 176 21 retention retention NN cord-326015-ky4y2xjt 176 22 of of IN cord-326015-ky4y2xjt 176 23 transmembrane transmembrane JJ cord-326015-ky4y2xjt 176 24 proteins protein NNS cord-326015-ky4y2xjt 176 25 in in IN cord-326015-ky4y2xjt 176 26 the the DT cord-326015-ky4y2xjt 176 27 endoplasmic endoplasmic NN cord-326015-ky4y2xjt 176 28 reticulum reticulum NN cord-326015-ky4y2xjt 176 29 Recycling Recycling NNP cord-326015-ky4y2xjt 176 30 of of IN cord-326015-ky4y2xjt 176 31 proteins protein NNS cord-326015-ky4y2xjt 176 32 from from IN cord-326015-ky4y2xjt 176 33 the the DT cord-326015-ky4y2xjt 176 34 Golgi Golgi NNP cord-326015-ky4y2xjt 176 35 compartment compartment NN cord-326015-ky4y2xjt 176 36 to to IN cord-326015-ky4y2xjt 176 37 the the DT cord-326015-ky4y2xjt 176 38 ER ER NNP cord-326015-ky4y2xjt 176 39 in in IN cord-326015-ky4y2xjt 176 40 yeast yeast NN cord-326015-ky4y2xjt 176 41 Retrieval Retrieval NNP cord-326015-ky4y2xjt 176 42 of of IN cord-326015-ky4y2xjt 176 43 transmembrane transmembrane NNP cord-326015-ky4y2xjt 176 44 proteins protein NNS cord-326015-ky4y2xjt 176 45 to to IN cord-326015-ky4y2xjt 176 46 the the DT cord-326015-ky4y2xjt 176 47 endoplasmic endoplasmic NN cord-326015-ky4y2xjt 176 48 reticulum reticulum NN cord-326015-ky4y2xjt 176 49 ERD1 ERD1 NNP cord-326015-ky4y2xjt 176 50 , , , cord-326015-ky4y2xjt 176 51 a a DT cord-326015-ky4y2xjt 176 52 yeast yeast NN cord-326015-ky4y2xjt 176 53 gene gene NN cord-326015-ky4y2xjt 176 54 required require VBN cord-326015-ky4y2xjt 176 55 for for IN cord-326015-ky4y2xjt 176 56 the the DT cord-326015-ky4y2xjt 176 57 retention retention NN cord-326015-ky4y2xjt 176 58 of of IN cord-326015-ky4y2xjt 176 59 luminal luminal JJ cord-326015-ky4y2xjt 176 60 endoplasmic endoplasmic NN cord-326015-ky4y2xjt 176 61 reticulum reticulum NN cord-326015-ky4y2xjt 176 62 proteins protein NNS cord-326015-ky4y2xjt 176 63 , , , cord-326015-ky4y2xjt 176 64 a¡ects a¡ect VBZ cord-326015-ky4y2xjt 176 65 glycoprotein glycoprotein NN cord-326015-ky4y2xjt 176 66 processing processing NN cord-326015-ky4y2xjt 176 67 in in IN cord-326015-ky4y2xjt 176 68 the the DT cord-326015-ky4y2xjt 176 69 Golgi Golgi NNP cord-326015-ky4y2xjt 176 70 apparatus apparatus NN cord-326015-ky4y2xjt 176 71 Localization Localization NNP cord-326015-ky4y2xjt 176 72 of of IN cord-326015-ky4y2xjt 176 73 Sed5 Sed5 NNP cord-326015-ky4y2xjt 176 74 , , , cord-326015-ky4y2xjt 176 75 a a DT cord-326015-ky4y2xjt 176 76 putative putative JJ cord-326015-ky4y2xjt 176 77 vesicle vesicle NN cord-326015-ky4y2xjt 176 78 targeting target VBG cord-326015-ky4y2xjt 176 79 molecule molecule NN cord-326015-ky4y2xjt 176 80 , , , cord-326015-ky4y2xjt 176 81 to to IN cord-326015-ky4y2xjt 176 82 the the DT cord-326015-ky4y2xjt 176 83 cis cis NNP cord-326015-ky4y2xjt 176 84 - - HYPH cord-326015-ky4y2xjt 176 85 Golgi Golgi NNP cord-326015-ky4y2xjt 176 86 network network NN cord-326015-ky4y2xjt 176 87 involves involve VBZ cord-326015-ky4y2xjt 176 88 both both CC cord-326015-ky4y2xjt 176 89 its -PRON- PRP$ cord-326015-ky4y2xjt 176 90 transmembrane transmembrane NN cord-326015-ky4y2xjt 176 91 and and CC cord-326015-ky4y2xjt 176 92 cytoplasmic cytoplasmic JJ cord-326015-ky4y2xjt 176 93 domains domain NNS cord-326015-ky4y2xjt 176 94 Localization Localization NNP cord-326015-ky4y2xjt 176 95 of of IN cord-326015-ky4y2xjt 176 96 the the DT cord-326015-ky4y2xjt 176 97 Lys Lys NNP cord-326015-ky4y2xjt 176 98 , , , cord-326015-ky4y2xjt 176 99 Asp Asp NNP cord-326015-ky4y2xjt 176 100 , , , cord-326015-ky4y2xjt 176 101 Glu Glu NNP cord-326015-ky4y2xjt 176 102 , , , cord-326015-ky4y2xjt 176 103 Leu Leu NNP cord-326015-ky4y2xjt 176 104 tetrapeptide tetrapeptide NN cord-326015-ky4y2xjt 176 105 receptor receptor NN cord-326015-ky4y2xjt 176 106 to to IN cord-326015-ky4y2xjt 176 107 the the DT cord-326015-ky4y2xjt 176 108 Golgi Golgi NNP cord-326015-ky4y2xjt 176 109 complex complex NN cord-326015-ky4y2xjt 176 110 and and CC cord-326015-ky4y2xjt 176 111 the the DT cord-326015-ky4y2xjt 176 112 intermediate intermediate JJ cord-326015-ky4y2xjt 176 113 compartment compartment NN cord-326015-ky4y2xjt 176 114 in in IN cord-326015-ky4y2xjt 176 115 mammalian mammalian JJ cord-326015-ky4y2xjt 176 116 cells cell NNS cord-326015-ky4y2xjt 176 117 Coatomer Coatomer NNP cord-326015-ky4y2xjt 176 118 interaction interaction NN cord-326015-ky4y2xjt 176 119 with with IN cord-326015-ky4y2xjt 176 120 di di NN cord-326015-ky4y2xjt 176 121 - - HYPH cord-326015-ky4y2xjt 176 122 lysine lysine JJ cord-326015-ky4y2xjt 176 123 endoplasmic endoplasmic NN cord-326015-ky4y2xjt 176 124 reticulum reticulum NN cord-326015-ky4y2xjt 176 125 retention retention NN cord-326015-ky4y2xjt 176 126 motifs motif NNS cord-326015-ky4y2xjt 177 1 Coatomer Coatomer NNP cord-326015-ky4y2xjt 177 2 is be VBZ cord-326015-ky4y2xjt 177 3 essential essential JJ cord-326015-ky4y2xjt 177 4 for for IN cord-326015-ky4y2xjt 177 5 retrieval retrieval NN cord-326015-ky4y2xjt 177 6 of of IN cord-326015-ky4y2xjt 177 7 dilysine dilysine NN cord-326015-ky4y2xjt 177 8 - - HYPH cord-326015-ky4y2xjt 177 9 tagged tag VBN cord-326015-ky4y2xjt 177 10 proteins protein NNS cord-326015-ky4y2xjt 177 11 to to IN cord-326015-ky4y2xjt 177 12 the the DT cord-326015-ky4y2xjt 177 13 endoplasmic endoplasmic NN cord-326015-ky4y2xjt 177 14 reticulum reticulum NN cord-326015-ky4y2xjt 177 15 Rothman Rothman NNP cord-326015-ky4y2xjt 177 16 , , , cord-326015-ky4y2xjt 177 17 Puri¢cation puri¢cation NN cord-326015-ky4y2xjt 177 18 of of IN cord-326015-ky4y2xjt 177 19 a a DT cord-326015-ky4y2xjt 177 20 novel novel JJ cord-326015-ky4y2xjt 177 21 class class NN cord-326015-ky4y2xjt 177 22 of of IN cord-326015-ky4y2xjt 177 23 coated coated JJ cord-326015-ky4y2xjt 177 24 vesicles vesicle NNS cord-326015-ky4y2xjt 177 25 mediating mediate VBG cord-326015-ky4y2xjt 177 26 biosynthetic biosynthetic JJ cord-326015-ky4y2xjt 177 27 protein protein NN cord-326015-ky4y2xjt 177 28 transport transport NN cord-326015-ky4y2xjt 177 29 through through IN cord-326015-ky4y2xjt 177 30 the the DT cord-326015-ky4y2xjt 177 31 Golgi Golgi NNP cord-326015-ky4y2xjt 177 32 stack stack NN cord-326015-ky4y2xjt 177 33 ERGIC-53 ERGIC-53 NNP cord-326015-ky4y2xjt 177 34 , , , cord-326015-ky4y2xjt 177 35 a a DT cord-326015-ky4y2xjt 177 36 membrane membrane NN cord-326015-ky4y2xjt 177 37 protein protein NN cord-326015-ky4y2xjt 177 38 of of IN cord-326015-ky4y2xjt 177 39 the the DT cord-326015-ky4y2xjt 177 40 ER ER NNP cord-326015-ky4y2xjt 177 41 - - HYPH cord-326015-ky4y2xjt 177 42 Golgi Golgi NNP cord-326015-ky4y2xjt 177 43 intermediate intermediate JJ cord-326015-ky4y2xjt 177 44 compartment compartment NN cord-326015-ky4y2xjt 177 45 , , , cord-326015-ky4y2xjt 177 46 carries carry VBZ cord-326015-ky4y2xjt 177 47 an an DT cord-326015-ky4y2xjt 177 48 ER ER NNP cord-326015-ky4y2xjt 177 49 retention retention NN cord-326015-ky4y2xjt 177 50 motif motif NN cord-326015-ky4y2xjt 177 51 A a DT cord-326015-ky4y2xjt 177 52 major major JJ cord-326015-ky4y2xjt 177 53 transmembrane transmembrane NN cord-326015-ky4y2xjt 177 54 protein protein NN cord-326015-ky4y2xjt 177 55 of of IN cord-326015-ky4y2xjt 177 56 Golgi Golgi NNP cord-326015-ky4y2xjt 177 57 - - HYPH cord-326015-ky4y2xjt 177 58 derived derive VBN cord-326015-ky4y2xjt 177 59 COPI COPI NNP cord-326015-ky4y2xjt 177 60 - - HYPH cord-326015-ky4y2xjt 177 61 coated coat VBN cord-326015-ky4y2xjt 177 62 vesicles vesicle NNS cord-326015-ky4y2xjt 177 63 involved involve VBN cord-326015-ky4y2xjt 177 64 in in IN cord-326015-ky4y2xjt 177 65 coatomer coatomer NN cord-326015-ky4y2xjt 177 66 binding bind VBG cord-326015-ky4y2xjt 177 67 Involvement Involvement NNP cord-326015-ky4y2xjt 177 68 of of IN cord-326015-ky4y2xjt 177 69 the the DT cord-326015-ky4y2xjt 177 70 transmembrane transmembrane NNP cord-326015-ky4y2xjt 177 71 protein protein NN cord-326015-ky4y2xjt 177 72 p23 p23 NN cord-326015-ky4y2xjt 177 73 in in IN cord-326015-ky4y2xjt 177 74 biosynthetic biosynthetic JJ cord-326015-ky4y2xjt 177 75 protein protein NN cord-326015-ky4y2xjt 177 76 transport transport NN cord-326015-ky4y2xjt 178 1 The the DT cord-326015-ky4y2xjt 178 2 Recycling Recycling NNP cord-326015-ky4y2xjt 178 3 of of IN cord-326015-ky4y2xjt 178 4 ERGIC-53 ERGIC-53 NNP cord-326015-ky4y2xjt 178 5 in in IN cord-326015-ky4y2xjt 178 6 the the DT cord-326015-ky4y2xjt 178 7 Early Early NNP cord-326015-ky4y2xjt 178 8 Secretory Secretory NNP cord-326015-ky4y2xjt 178 9 Pathway Pathway NNP cord-326015-ky4y2xjt 178 10 . . . cord-326015-ky4y2xjt 179 1 ERGIC-53 ERGIC-53 NNP cord-326015-ky4y2xjt 179 2 carries carry VBZ cord-326015-ky4y2xjt 179 3 a a DT cord-326015-ky4y2xjt 179 4 cytosolic cytosolic JJ cord-326015-ky4y2xjt 179 5 endoplasmic endoplasmic NN cord-326015-ky4y2xjt 179 6 reticulum reticulum NN cord-326015-ky4y2xjt 179 7 determinant determinant NN cord-326015-ky4y2xjt 179 8 interacting interact VBG cord-326015-ky4y2xjt 179 9 with with IN cord-326015-ky4y2xjt 179 10 COP cop NN cord-326015-ky4y2xjt 179 11 II II NNP cord-326015-ky4y2xjt 179 12 A a DT cord-326015-ky4y2xjt 179 13 hypothesis hypothesis NN cord-326015-ky4y2xjt 179 14 on on IN cord-326015-ky4y2xjt 179 15 the the DT cord-326015-ky4y2xjt 179 16 tra¤c tra¤c NNP cord-326015-ky4y2xjt 179 17 of of IN cord-326015-ky4y2xjt 179 18 MG160 MG160 NNP cord-326015-ky4y2xjt 179 19 , , , cord-326015-ky4y2xjt 179 20 a a DT cord-326015-ky4y2xjt 179 21 medial medial JJ cord-326015-ky4y2xjt 179 22 Golgi Golgi NNP cord-326015-ky4y2xjt 179 23 sialoglycoprotein sialoglycoprotein NNP cord-326015-ky4y2xjt 179 24 , , , cord-326015-ky4y2xjt 179 25 from from IN cord-326015-ky4y2xjt 179 26 the the DT cord-326015-ky4y2xjt 179 27 trans trans NNP cord-326015-ky4y2xjt 179 28 - - NNP cord-326015-ky4y2xjt 179 29 Golgi Golgi NNP cord-326015-ky4y2xjt 179 30 network network NN cord-326015-ky4y2xjt 179 31 to to IN cord-326015-ky4y2xjt 179 32 the the DT cord-326015-ky4y2xjt 179 33 Golgi Golgi NNP cord-326015-ky4y2xjt 179 34 cisternae cisternae NNP cord-326015-ky4y2xjt 179 35 Warren Warren NNP cord-326015-ky4y2xjt 179 36 , , , cord-326015-ky4y2xjt 179 37 Evidence evidence NN cord-326015-ky4y2xjt 179 38 for for IN cord-326015-ky4y2xjt 179 39 recycling recycling NN cord-326015-ky4y2xjt 179 40 of of IN cord-326015-ky4y2xjt 179 41 the the DT cord-326015-ky4y2xjt 179 42 resident resident JJ cord-326015-ky4y2xjt 179 43 medial medial JJ cord-326015-ky4y2xjt 179 44 / / SYM cord-326015-ky4y2xjt 179 45 trans trans NNP cord-326015-ky4y2xjt 179 46 Golgi Golgi NNP cord-326015-ky4y2xjt 179 47 enzyme enzyme NN cord-326015-ky4y2xjt 179 48 , , , cord-326015-ky4y2xjt 179 49 N N NNP cord-326015-ky4y2xjt 179 50 - - HYPH cord-326015-ky4y2xjt 179 51 acetylglucosaminyltransferase acetylglucosaminyltransferase NNP cord-326015-ky4y2xjt 180 1 I -PRON- PRP cord-326015-ky4y2xjt 180 2 , , , cord-326015-ky4y2xjt 180 3 in in IN cord-326015-ky4y2xjt 180 4 ldlD ldld JJ cord-326015-ky4y2xjt 180 5 cells cell NNS cord-326015-ky4y2xjt 180 6 Localization localization NN cord-326015-ky4y2xjt 180 7 of of IN cord-326015-ky4y2xjt 180 8 a a DT cord-326015-ky4y2xjt 180 9 yeast yeast NN cord-326015-ky4y2xjt 180 10 early early JJ cord-326015-ky4y2xjt 180 11 Golgi Golgi NNP cord-326015-ky4y2xjt 180 12 mannosyltransferase mannosyltransferase NN cord-326015-ky4y2xjt 180 13 , , , cord-326015-ky4y2xjt 180 14 Och Och NNP cord-326015-ky4y2xjt 180 15 1p 1p NN cord-326015-ky4y2xjt 180 16 , , , cord-326015-ky4y2xjt 180 17 involves involve VBZ cord-326015-ky4y2xjt 180 18 retrograde retrograde JJ cord-326015-ky4y2xjt 180 19 transport transport NN cord-326015-ky4y2xjt 180 20 Rapid rapid JJ cord-326015-ky4y2xjt 180 21 redistribution redistribution NN cord-326015-ky4y2xjt 180 22 of of IN cord-326015-ky4y2xjt 180 23 Golgi Golgi NNP cord-326015-ky4y2xjt 180 24 proteins protein NNS cord-326015-ky4y2xjt 180 25 into into IN cord-326015-ky4y2xjt 180 26 the the DT cord-326015-ky4y2xjt 180 27 ER ER NNP cord-326015-ky4y2xjt 180 28 in in IN cord-326015-ky4y2xjt 180 29 cells cell NNS cord-326015-ky4y2xjt 180 30 treated treat VBN cord-326015-ky4y2xjt 180 31 with with IN cord-326015-ky4y2xjt 180 32 brefeldin brefeldin NNS cord-326015-ky4y2xjt 180 33 A a NN cord-326015-ky4y2xjt 180 34 : : : cord-326015-ky4y2xjt 180 35 evidence evidence NN cord-326015-ky4y2xjt 180 36 for for IN cord-326015-ky4y2xjt 180 37 membrane membrane NN cord-326015-ky4y2xjt 180 38 cycling cycle VBG cord-326015-ky4y2xjt 180 39 from from IN cord-326015-ky4y2xjt 180 40 Golgi Golgi NNP cord-326015-ky4y2xjt 180 41 to to IN cord-326015-ky4y2xjt 180 42 ER ER NNP cord-326015-ky4y2xjt 180 43 Retention Retention NNP cord-326015-ky4y2xjt 180 44 of of IN cord-326015-ky4y2xjt 180 45 membrane membrane NN cord-326015-ky4y2xjt 180 46 proteins protein NNS cord-326015-ky4y2xjt 180 47 by by IN cord-326015-ky4y2xjt 180 48 the the DT cord-326015-ky4y2xjt 180 49 endoplasmic endoplasmic NN cord-326015-ky4y2xjt 180 50 reticulum reticulum NN