id sid tid token lemma pos cord-298503-l60cdllh 1 1 key key JJ cord-298503-l60cdllh 1 2 : : : cord-298503-l60cdllh 1 3 cord-298503-l60cdllh cord-298503-l60cdllh JJ cord-298503-l60cdllh 1 4 authors author NNS cord-298503-l60cdllh 1 5 : : : cord-298503-l60cdllh 1 6 Saraste Saraste NNP cord-298503-l60cdllh 1 7 , , , cord-298503-l60cdllh 1 8 J. J. NNP cord-298503-l60cdllh 1 9 ; ; : cord-298503-l60cdllh 1 10 Marie Marie NNP cord-298503-l60cdllh 1 11 , , , cord-298503-l60cdllh 1 12 M. M. NNP cord-298503-l60cdllh 1 13 title title NN cord-298503-l60cdllh 1 14 : : : cord-298503-l60cdllh 1 15 Intermediate Intermediate NNP cord-298503-l60cdllh 1 16 Compartment Compartment NNP cord-298503-l60cdllh 1 17 : : : cord-298503-l60cdllh 2 1 A a DT cord-298503-l60cdllh 2 2 Sorting Sorting NNP cord-298503-l60cdllh 2 3 Station Station NNP cord-298503-l60cdllh 2 4 between between IN cord-298503-l60cdllh 2 5 the the DT cord-298503-l60cdllh 2 6 Endoplasmic Endoplasmic NNP cord-298503-l60cdllh 2 7 Reticulum Reticulum NNP cord-298503-l60cdllh 2 8 and and CC cord-298503-l60cdllh 2 9 the the DT cord-298503-l60cdllh 2 10 Golgi Golgi NNP cord-298503-l60cdllh 2 11 Apparatus Apparatus NNP cord-298503-l60cdllh 2 12 date date NN cord-298503-l60cdllh 2 13 : : : cord-298503-l60cdllh 2 14 2015 2015 CD cord-298503-l60cdllh 2 15 - - HYPH cord-298503-l60cdllh 2 16 08 08 CD cord-298503-l60cdllh 2 17 - - SYM cord-298503-l60cdllh 2 18 20 20 CD cord-298503-l60cdllh 2 19 journal journal NN cord-298503-l60cdllh 2 20 : : : cord-298503-l60cdllh 3 1 Encyclopedia Encyclopedia NNP cord-298503-l60cdllh 3 2 of of IN cord-298503-l60cdllh 3 3 Cell Cell NNP cord-298503-l60cdllh 3 4 Biology Biology NNP cord-298503-l60cdllh 3 5 DOI doi NN cord-298503-l60cdllh 3 6 : : : cord-298503-l60cdllh 3 7 10.1016 10.1016 CD cord-298503-l60cdllh 3 8 / / SYM cord-298503-l60cdllh 3 9 b978 b978 NN cord-298503-l60cdllh 3 10 - - HYPH cord-298503-l60cdllh 3 11 0 0 CD cord-298503-l60cdllh 3 12 - - HYPH cord-298503-l60cdllh 3 13 12 12 CD cord-298503-l60cdllh 3 14 - - HYPH cord-298503-l60cdllh 3 15 394447 394447 CD cord-298503-l60cdllh 3 16 - - HYPH cord-298503-l60cdllh 3 17 4.20013 4.20013 CD cord-298503-l60cdllh 3 18 - - SYM cord-298503-l60cdllh 3 19 8 8 CD cord-298503-l60cdllh 3 20 sha sha NN cord-298503-l60cdllh 3 21 : : : cord-298503-l60cdllh 4 1 b92f186eac785ef058a89c4aa5a668b302a1c932 b92f186eac785ef058a89c4aa5a668b302a1c932 NNP cord-298503-l60cdllh 4 2 doc_id doc_id CD cord-298503-l60cdllh 4 3 : : : cord-298503-l60cdllh 4 4 298503 298503 CD cord-298503-l60cdllh 4 5 cord_uid cord_uid NNS cord-298503-l60cdllh 4 6 : : : cord-298503-l60cdllh 4 7 l60cdllh l60cdllh ADD cord-298503-l60cdllh 5 1 The the DT cord-298503-l60cdllh 5 2 intermediate intermediate JJ cord-298503-l60cdllh 5 3 compartment compartment NN cord-298503-l60cdllh 5 4 ( ( -LRB- cord-298503-l60cdllh 5 5 IC IC NNP cord-298503-l60cdllh 5 6 ) ) -RRB- cord-298503-l60cdllh 5 7 is be VBZ cord-298503-l60cdllh 5 8 a a DT cord-298503-l60cdllh 5 9 pleiomorphic pleiomorphic JJ cord-298503-l60cdllh 5 10 membrane membrane NN cord-298503-l60cdllh 5 11 system system NN cord-298503-l60cdllh 5 12 that that WDT cord-298503-l60cdllh 5 13 mediates mediate VBZ cord-298503-l60cdllh 5 14 two two CD cord-298503-l60cdllh 5 15 - - HYPH cord-298503-l60cdllh 5 16 way way NN cord-298503-l60cdllh 5 17 trafficing trafficing NN cord-298503-l60cdllh 5 18 in in IN cord-298503-l60cdllh 5 19 the the DT cord-298503-l60cdllh 5 20 early early JJ cord-298503-l60cdllh 5 21 biosynthetic biosynthetic JJ cord-298503-l60cdllh 5 22 - - HYPH cord-298503-l60cdllh 5 23 secretory secretory JJ cord-298503-l60cdllh 5 24 pathway pathway NN cord-298503-l60cdllh 5 25 of of IN cord-298503-l60cdllh 5 26 mammalian mammalian JJ cord-298503-l60cdllh 5 27 cells cell NNS cord-298503-l60cdllh 5 28 . . . cord-298503-l60cdllh 6 1 The the DT cord-298503-l60cdllh 6 2 IC IC NNP cord-298503-l60cdllh 6 3 associates associate NNS cord-298503-l60cdllh 6 4 with with IN cord-298503-l60cdllh 6 5 the the DT cord-298503-l60cdllh 6 6 cytoskeleton cytoskeleton NN cord-298503-l60cdllh 6 7 , , , cord-298503-l60cdllh 6 8 binds bind VBZ cord-298503-l60cdllh 6 9 COPI COPI NNP cord-298503-l60cdllh 6 10 ( ( -LRB- cord-298503-l60cdllh 6 11 coat coat NN cord-298503-l60cdllh 6 12 protein protein NN cord-298503-l60cdllh 6 13 I i CD cord-298503-l60cdllh 6 14 ) ) -RRB- cord-298503-l60cdllh 6 15 coats coat NNS cord-298503-l60cdllh 6 16 and and CC cord-298503-l60cdllh 6 17 generates generate VBZ cord-298503-l60cdllh 6 18 vesicular vesicular JJ cord-298503-l60cdllh 6 19 , , , cord-298503-l60cdllh 6 20 tubular tubular JJ cord-298503-l60cdllh 6 21 and and CC cord-298503-l60cdllh 6 22 saccular saccular JJ cord-298503-l60cdllh 6 23 transport transport NN cord-298503-l60cdllh 6 24 carriers carrier NNS cord-298503-l60cdllh 6 25 . . . cord-298503-l60cdllh 7 1 It -PRON- PRP cord-298503-l60cdllh 7 2 recieves recieve VBZ cord-298503-l60cdllh 7 3 newly newly RB cord-298503-l60cdllh 7 4 made make VBN cord-298503-l60cdllh 7 5 proteins protein NNS cord-298503-l60cdllh 7 6 and and CC cord-298503-l60cdllh 7 7 lipids lipid NNS cord-298503-l60cdllh 7 8 from from IN cord-298503-l60cdllh 7 9 the the DT cord-298503-l60cdllh 7 10 endoplasmic endoplasmic NN cord-298503-l60cdllh 7 11 reticulum reticulum NN cord-298503-l60cdllh 7 12 ( ( -LRB- cord-298503-l60cdllh 7 13 ER ER NNP cord-298503-l60cdllh 7 14 ) ) -RRB- cord-298503-l60cdllh 7 15 and and CC cord-298503-l60cdllh 7 16 sorts sort VBZ cord-298503-l60cdllh 7 17 them -PRON- PRP cord-298503-l60cdllh 7 18 for for IN cord-298503-l60cdllh 7 19 transport transport NN cord-298503-l60cdllh 7 20 to to IN cord-298503-l60cdllh 7 21 the the DT cord-298503-l60cdllh 7 22 Golgi Golgi NNP cord-298503-l60cdllh 7 23 apparatus apparatus NN cord-298503-l60cdllh 7 24 or or CC cord-298503-l60cdllh 7 25 recycling recycling NN cord-298503-l60cdllh 7 26 back back RB cord-298503-l60cdllh 7 27 to to IN cord-298503-l60cdllh 7 28 the the DT cord-298503-l60cdllh 7 29 ER ER NNP cord-298503-l60cdllh 7 30 . . . cord-298503-l60cdllh 8 1 Although although IN cord-298503-l60cdllh 8 2 the the DT cord-298503-l60cdllh 8 3 IC IC NNP cord-298503-l60cdllh 8 4 appears appear VBZ cord-298503-l60cdllh 8 5 to to TO cord-298503-l60cdllh 8 6 be be VB cord-298503-l60cdllh 8 7 functionally functionally RB cord-298503-l60cdllh 8 8 complex complex JJ cord-298503-l60cdllh 8 9 and and CC cord-298503-l60cdllh 8 10 resides reside VBZ cord-298503-l60cdllh 8 11 at at IN cord-298503-l60cdllh 8 12 the the DT cord-298503-l60cdllh 8 13 crossroads crossroad NNS cord-298503-l60cdllh 8 14 of of IN cord-298503-l60cdllh 8 15 multiple multiple JJ cord-298503-l60cdllh 8 16 transport transport NN cord-298503-l60cdllh 8 17 routes route NNS cord-298503-l60cdllh 8 18 , , , cord-298503-l60cdllh 8 19 it -PRON- PRP cord-298503-l60cdllh 8 20 is be VBZ cord-298503-l60cdllh 8 21 still still RB cord-298503-l60cdllh 8 22 disputed dispute VBN cord-298503-l60cdllh 8 23 whether whether IN cord-298503-l60cdllh 8 24 it -PRON- PRP cord-298503-l60cdllh 8 25 represents represent VBZ cord-298503-l60cdllh 8 26 a a DT cord-298503-l60cdllh 8 27 transient transient JJ cord-298503-l60cdllh 8 28 or or CC cord-298503-l60cdllh 8 29 stable stable JJ cord-298503-l60cdllh 8 30 structure structure NN cord-298503-l60cdllh 8 31 . . . cord-298503-l60cdllh 9 1 Newly newly RB cord-298503-l60cdllh 9 2 synthesized synthesize VBN cord-298503-l60cdllh 9 3 proteins protein NNS cord-298503-l60cdllh 9 4 and and CC cord-298503-l60cdllh 9 5 lipids lipid NNS cord-298503-l60cdllh 9 6 leave leave VBP cord-298503-l60cdllh 9 7 the the DT cord-298503-l60cdllh 9 8 endoplasmic endoplasmic NN cord-298503-l60cdllh 9 9 reticulum reticulum NN cord-298503-l60cdllh 9 10 ( ( -LRB- cord-298503-l60cdllh 9 11 ER ER NNP cord-298503-l60cdllh 9 12 ) ) -RRB- cord-298503-l60cdllh 9 13 at at IN cord-298503-l60cdllh 9 14 specialized specialized JJ cord-298503-l60cdllh 9 15 transitional transitional JJ cord-298503-l60cdllh 9 16 regions region NNS cord-298503-l60cdllh 9 17 called call VBN cord-298503-l60cdllh 9 18 ER ER NNP cord-298503-l60cdllh 9 19 exit exit NN cord-298503-l60cdllh 9 20 sites site NNS cord-298503-l60cdllh 9 21 ( ( -LRB- cord-298503-l60cdllh 9 22 ERES ERES NNP cord-298503-l60cdllh 9 23 ) ) -RRB- cord-298503-l60cdllh 10 1 ( ( -LRB- cord-298503-l60cdllh 10 2 Jamieson Jamieson NNP cord-298503-l60cdllh 10 3 and and CC cord-298503-l60cdllh 10 4 Palade Palade NNP cord-298503-l60cdllh 10 5 , , , cord-298503-l60cdllh 10 6 1967 1967 CD cord-298503-l60cdllh 10 7 ; ; : cord-298503-l60cdllh 10 8 Sesso Sesso NNP cord-298503-l60cdllh 10 9 et et FW cord-298503-l60cdllh 10 10 al al NNP cord-298503-l60cdllh 10 11 . . NNP cord-298503-l60cdllh 10 12 , , , cord-298503-l60cdllh 10 13 1994 1994 CD cord-298503-l60cdllh 10 14 ; ; : cord-298503-l60cdllh 10 15 Bannykh Bannykh NNP cord-298503-l60cdllh 10 16 et et NNP cord-298503-l60cdllh 10 17 al al NNP cord-298503-l60cdllh 10 18 . . NNP cord-298503-l60cdllh 10 19 , , , cord-298503-l60cdllh 10 20 1996 1996 CD cord-298503-l60cdllh 10 21 ; ; : cord-298503-l60cdllh 10 22 Hammond Hammond NNP cord-298503-l60cdllh 10 23 and and CC cord-298503-l60cdllh 10 24 Glick Glick NNP cord-298503-l60cdllh 10 25 , , , cord-298503-l60cdllh 10 26 2000 2000 CD cord-298503-l60cdllh 10 27 ; ; : cord-298503-l60cdllh 10 28 Tang Tang NNP cord-298503-l60cdllh 10 29 et et NNP cord-298503-l60cdllh 10 30 al al NNP cord-298503-l60cdllh 10 31 . . NNP cord-298503-l60cdllh 10 32 , , , cord-298503-l60cdllh 10 33 2005 2005 CD cord-298503-l60cdllh 10 34 ) ) -RRB- cord-298503-l60cdllh 10 35 and and CC cord-298503-l60cdllh 10 36 enter enter VB cord-298503-l60cdllh 10 37 the the DT cord-298503-l60cdllh 10 38 intermediate intermediate JJ cord-298503-l60cdllh 10 39 compartment compartment NN cord-298503-l60cdllh 10 40 ( ( -LRB- cord-298503-l60cdllh 10 41 IC IC NNP cord-298503-l60cdllh 10 42 ) ) -RRB- cord-298503-l60cdllh 10 43 that that WDT cord-298503-l60cdllh 10 44 has have VBZ cord-298503-l60cdllh 10 45 been be VBN cord-298503-l60cdllh 10 46 shown show VBN cord-298503-l60cdllh 10 47 to to TO cord-298503-l60cdllh 10 48 operate operate VB cord-298503-l60cdllh 10 49 as as IN cord-298503-l60cdllh 10 50 an an DT cord-298503-l60cdllh 10 51 obligatory obligatory JJ cord-298503-l60cdllh 10 52 a a DT cord-298503-l60cdllh 10 53 post post JJ cord-298503-l60cdllh 10 54 - - JJ cord-298503-l60cdllh 10 55 ER er JJ cord-298503-l60cdllh 10 56 sorting sorting NN cord-298503-l60cdllh 10 57 station station NN cord-298503-l60cdllh 10 58 in in IN cord-298503-l60cdllh 10 59 the the DT cord-298503-l60cdllh 10 60 early early JJ cord-298503-l60cdllh 10 61 biosynthetic biosynthetic JJ cord-298503-l60cdllh 10 62 - - HYPH cord-298503-l60cdllh 10 63 secretory secretory JJ cord-298503-l60cdllh 10 64 trafficking trafficking NN cord-298503-l60cdllh 10 65 of of IN cord-298503-l60cdllh 10 66 mammalian mammalian JJ cord-298503-l60cdllh 10 67 cells cell NNS cord-298503-l60cdllh 10 68 . . . cord-298503-l60cdllh 11 1 From from IN cord-298503-l60cdllh 11 2 the the DT cord-298503-l60cdllh 11 3 IC IC NNP cord-298503-l60cdllh 11 4 they -PRON- PRP cord-298503-l60cdllh 11 5 are be VBP cord-298503-l60cdllh 11 6 typically typically RB cord-298503-l60cdllh 11 7 transported transport VBN cord-298503-l60cdllh 11 8 to to IN cord-298503-l60cdllh 11 9 the the DT cord-298503-l60cdllh 11 10 cisternal cisternal JJ cord-298503-l60cdllh 11 11 stacks stack NNS cord-298503-l60cdllh 11 12 of of IN cord-298503-l60cdllh 11 13 the the DT cord-298503-l60cdllh 11 14 Golgi Golgi NNP cord-298503-l60cdllh 11 15 apparatus apparatus NN cord-298503-l60cdllh 11 16 , , , cord-298503-l60cdllh 11 17 prior prior RB cord-298503-l60cdllh 11 18 to to IN cord-298503-l60cdllh 11 19 their -PRON- PRP$ cord-298503-l60cdllh 11 20 delivery delivery NN cord-298503-l60cdllh 11 21 to to IN cord-298503-l60cdllh 11 22 the the DT cord-298503-l60cdllh 11 23 different different JJ cord-298503-l60cdllh 11 24 organelles organelle NNS cord-298503-l60cdllh 11 25 of of IN cord-298503-l60cdllh 11 26 the the DT cord-298503-l60cdllh 11 27 endomembrane endomembrane NNP cord-298503-l60cdllh 11 28 system system NN cord-298503-l60cdllh 11 29 or or CC cord-298503-l60cdllh 11 30 secretion secretion NN cord-298503-l60cdllh 11 31 to to IN cord-298503-l60cdllh 11 32 the the DT cord-298503-l60cdllh 11 33 extracellular extracellular JJ cord-298503-l60cdllh 11 34 space space NN cord-298503-l60cdllh 11 35 . . . cord-298503-l60cdllh 12 1 Bidirectional bidirectional JJ cord-298503-l60cdllh 12 2 ER ER NNP cord-298503-l60cdllh 12 3 - - HYPH cord-298503-l60cdllh 12 4 Golgi golgi NN cord-298503-l60cdllh 12 5 trafficking trafficking NN cord-298503-l60cdllh 12 6 involves involve VBZ cord-298503-l60cdllh 12 7 the the DT cord-298503-l60cdllh 12 8 sequential sequential JJ cord-298503-l60cdllh 12 9 operation operation NN cord-298503-l60cdllh 12 10 of of IN cord-298503-l60cdllh 12 11 membrane membrane NN cord-298503-l60cdllh 12 12 - - HYPH cord-298503-l60cdllh 12 13 bound bind VBN cord-298503-l60cdllh 12 14 coat coat NN cord-298503-l60cdllh 12 15 protein protein NN cord-298503-l60cdllh 12 16 II II NNP cord-298503-l60cdllh 12 17 ( ( -LRB- cord-298503-l60cdllh 12 18 COPII COPII NNP cord-298503-l60cdllh 12 19 ) ) -RRB- cord-298503-l60cdllh 12 20 and and CC cord-298503-l60cdllh 12 21 COPI COPI NNP cord-298503-l60cdllh 12 22 coats coat NNS cord-298503-l60cdllh 12 23 ( ( -LRB- cord-298503-l60cdllh 12 24 Aridor Aridor NNP cord-298503-l60cdllh 12 25 and and CC cord-298503-l60cdllh 12 26 Balch Balch NNP cord-298503-l60cdllh 12 27 , , , cord-298503-l60cdllh 12 28 1996 1996 CD cord-298503-l60cdllh 12 29 ; ; : cord-298503-l60cdllh 12 30 Scales Scales NNP cord-298503-l60cdllh 12 31 et et NNP cord-298503-l60cdllh 12 32 al al NNP cord-298503-l60cdllh 12 33 . . NNP cord-298503-l60cdllh 12 34 , , , cord-298503-l60cdllh 12 35 1997 1997 CD cord-298503-l60cdllh 12 36 ; ; : cord-298503-l60cdllh 12 37 Stephens Stephens NNP cord-298503-l60cdllh 12 38 et et NNP cord-298503-l60cdllh 12 39 al al NNP cord-298503-l60cdllh 12 40 . . NNP cord-298503-l60cdllh 12 41 , , , cord-298503-l60cdllh 12 42 2000 2000 CD cord-298503-l60cdllh 12 43 ) ) -RRB- cord-298503-l60cdllh 12 44 . . . cord-298503-l60cdllh 13 1 ER ER NNP cord-298503-l60cdllh 13 2 - - HYPH cord-298503-l60cdllh 13 3 derived derive VBN cord-298503-l60cdllh 13 4 COPII COPII NNP cord-298503-l60cdllh 13 5 vesicles vesicle NNS cord-298503-l60cdllh 13 6 mediate mediate VBP cord-298503-l60cdllh 13 7 forward forward RB cord-298503-l60cdllh 13 8 ( ( -LRB- cord-298503-l60cdllh 13 9 anterograde anterograde JJ cord-298503-l60cdllh 13 10 ) ) -RRB- cord-298503-l60cdllh 13 11 transport transport NN cord-298503-l60cdllh 13 12 , , , cord-298503-l60cdllh 13 13 while while IN cord-298503-l60cdllh 13 14 IC IC NNP cord-298503-l60cdllh 13 15 - - : cord-298503-l60cdllh 13 16 and and CC cord-298503-l60cdllh 13 17 Golgi Golgi NNP cord-298503-l60cdllh 13 18 - - HYPH cord-298503-l60cdllh 13 19 derived derive VBN cord-298503-l60cdllh 13 20 COPI COPI NNP cord-298503-l60cdllh 13 21 vesicles vesicle NNS cord-298503-l60cdllh 13 22 are be VBP cord-298503-l60cdllh 13 23 thought think VBN cord-298503-l60cdllh 13 24 to to TO cord-298503-l60cdllh 13 25 act act VB cord-298503-l60cdllh 13 26 in in IN cord-298503-l60cdllh 13 27 the the DT cord-298503-l60cdllh 13 28 opposite opposite JJ cord-298503-l60cdllh 13 29 ( ( -LRB- cord-298503-l60cdllh 13 30 retrograde retrograde JJ cord-298503-l60cdllh 13 31 ) ) -RRB- cord-298503-l60cdllh 13 32 direction direction NN cord-298503-l60cdllh 14 1 ( ( -LRB- cord-298503-l60cdllh 14 2 Lee Lee NNP cord-298503-l60cdllh 14 3 et et NNP cord-298503-l60cdllh 14 4 al al NNP cord-298503-l60cdllh 14 5 . . NNP cord-298503-l60cdllh 14 6 , , , cord-298503-l60cdllh 14 7 2004 2004 CD cord-298503-l60cdllh 14 8 ; ; : cord-298503-l60cdllh 14 9 Rabouille Rabouille NNP cord-298503-l60cdllh 14 10 and and CC cord-298503-l60cdllh 14 11 Klumperman Klumperman NNP cord-298503-l60cdllh 14 12 , , , cord-298503-l60cdllh 14 13 2005 2005 CD cord-298503-l60cdllh 14 14 ) ) -RRB- cord-298503-l60cdllh 14 15 . . . cord-298503-l60cdllh 15 1 Retrograde retrograde JJ cord-298503-l60cdllh 15 2 transport transport NN cord-298503-l60cdllh 15 3 also also RB cord-298503-l60cdllh 15 4 involves involve VBZ cord-298503-l60cdllh 15 5 COPIindependent copiindependent NN cord-298503-l60cdllh 15 6 routes route NNS cord-298503-l60cdllh 15 7 ( ( -LRB- cord-298503-l60cdllh 15 8 Kano Kano NNP cord-298503-l60cdllh 15 9 et et NNP cord-298503-l60cdllh 15 10 al al NNP cord-298503-l60cdllh 15 11 . . NNP cord-298503-l60cdllh 15 12 , , , cord-298503-l60cdllh 15 13 2009 2009 CD cord-298503-l60cdllh 15 14 ) ) -RRB- cord-298503-l60cdllh 15 15 . . . cord-298503-l60cdllh 16 1 Despite despite IN cord-298503-l60cdllh 16 2 the the DT cord-298503-l60cdllh 16 3 conservation conservation NN cord-298503-l60cdllh 16 4 of of IN cord-298503-l60cdllh 16 5 the the DT cord-298503-l60cdllh 16 6 transport transport NN cord-298503-l60cdllh 16 7 machineries machinery NNS cord-298503-l60cdllh 16 8 ( ( -LRB- cord-298503-l60cdllh 16 9 such such JJ cord-298503-l60cdllh 16 10 as as IN cord-298503-l60cdllh 16 11 the the DT cord-298503-l60cdllh 16 12 COP cop NN cord-298503-l60cdllh 16 13 coats coat NNS cord-298503-l60cdllh 16 14 ) ) -RRB- cord-298503-l60cdllh 16 15 , , , cord-298503-l60cdllh 16 16 the the DT cord-298503-l60cdllh 16 17 organization organization NN cord-298503-l60cdllh 16 18 of of IN cord-298503-l60cdllh 16 19 the the DT cord-298503-l60cdllh 16 20 ER ER NNP cord-298503-l60cdllh 16 21 - - HYPH cord-298503-l60cdllh 16 22 Golgi Golgi NNP cord-298503-l60cdllh 16 23 interface interface NN cord-298503-l60cdllh 16 24 varies vary VBZ cord-298503-l60cdllh 16 25 in in IN cord-298503-l60cdllh 16 26 different different JJ cord-298503-l60cdllh 16 27 eukaryotic eukaryotic JJ cord-298503-l60cdllh 16 28 cells cell NNS cord-298503-l60cdllh 16 29 . . . cord-298503-l60cdllh 17 1 For for IN cord-298503-l60cdllh 17 2 example example NN cord-298503-l60cdllh 17 3 , , , cord-298503-l60cdllh 17 4 in in IN cord-298503-l60cdllh 17 5 plants plant NNS cord-298503-l60cdllh 17 6 , , , cord-298503-l60cdllh 17 7 certain certain JJ cord-298503-l60cdllh 17 8 yeasts yeast NNS cord-298503-l60cdllh 17 9 , , , cord-298503-l60cdllh 17 10 and and CC cord-298503-l60cdllh 17 11 the the DT cord-298503-l60cdllh 17 12 fruit fruit NN cord-298503-l60cdllh 17 13 fly fly VBP cord-298503-l60cdllh 17 14 Drosophila Drosophila NNP cord-298503-l60cdllh 17 15 melanogaster melanogaster NN cord-298503-l60cdllh 17 16 , , , cord-298503-l60cdllh 17 17 the the DT cord-298503-l60cdllh 17 18 individual individual JJ cord-298503-l60cdllh 17 19 Golgi Golgi NNP cord-298503-l60cdllh 17 20 stacks stack NNS cord-298503-l60cdllh 17 21 lie lie NN cord-298503-l60cdllh 17 22 next next RB cord-298503-l60cdllh 17 23 to to IN cord-298503-l60cdllh 17 24 the the DT cord-298503-l60cdllh 17 25 widespread widespread JJ cord-298503-l60cdllh 17 26 ERES ERES NNP cord-298503-l60cdllh 17 27 , , , cord-298503-l60cdllh 17 28 establishing establish VBG cord-298503-l60cdllh 17 29 units unit NNS cord-298503-l60cdllh 17 30 for for IN cord-298503-l60cdllh 17 31 short short JJ cord-298503-l60cdllh 17 32 range range NN cord-298503-l60cdllh 17 33 ER ER NNP cord-298503-l60cdllh 17 34 - - HYPH cord-298503-l60cdllh 17 35 Golgi Golgi NNP cord-298503-l60cdllh 17 36 communication communication NN cord-298503-l60cdllh 17 37 . . . cord-298503-l60cdllh 18 1 By by IN cord-298503-l60cdllh 18 2 contrast contrast NN cord-298503-l60cdllh 18 3 , , , cord-298503-l60cdllh 18 4 in in IN cord-298503-l60cdllh 18 5 animal animal NN cord-298503-l60cdllh 18 6 cells cell NNS cord-298503-l60cdllh 18 7 the the DT cord-298503-l60cdllh 18 8 Golgi Golgi NNP cord-298503-l60cdllh 18 9 stacks stack NNS cord-298503-l60cdllh 18 10 are be VBP cord-298503-l60cdllh 18 11 linked link VBN cord-298503-l60cdllh 18 12 together together RB cord-298503-l60cdllh 18 13 into into IN cord-298503-l60cdllh 18 14 a a DT cord-298503-l60cdllh 18 15 continuous continuous JJ cord-298503-l60cdllh 18 16 ribbon ribbon NN cord-298503-l60cdllh 18 17 around around IN cord-298503-l60cdllh 18 18 the the DT cord-298503-l60cdllh 18 19 microtubule microtubule NN cord-298503-l60cdllh 18 20 - - HYPH cord-298503-l60cdllh 18 21 organizing organize VBG cord-298503-l60cdllh 18 22 center center NN cord-298503-l60cdllh 18 23 ( ( -LRB- cord-298503-l60cdllh 18 24 MTOC)/centrosome MTOC)/centrosome NNP cord-298503-l60cdllh 18 25 , , , cord-298503-l60cdllh 18 26 whereas whereas IN cord-298503-l60cdllh 18 27 the the DT cord-298503-l60cdllh 18 28 ER ER NNP cord-298503-l60cdllh 18 29 extends extend VBZ cord-298503-l60cdllh 18 30 throughout throughout IN cord-298503-l60cdllh 18 31 the the DT cord-298503-l60cdllh 18 32 cytoplasm cytoplasm NN cord-298503-l60cdllh 18 33 . . . cord-298503-l60cdllh 19 1 Hence hence RB cord-298503-l60cdllh 19 2 , , , cord-298503-l60cdllh 19 3 a a DT cord-298503-l60cdllh 19 4 large large JJ cord-298503-l60cdllh 19 5 proportion proportion NN cord-298503-l60cdllh 19 6 of of IN cord-298503-l60cdllh 19 7 the the DT cord-298503-l60cdllh 19 8 ERES ERES NNP cord-298503-l60cdllh 19 9 reside reside VB cord-298503-l60cdllh 19 10 at at IN cord-298503-l60cdllh 19 11 the the DT cord-298503-l60cdllh 19 12 cell cell NN cord-298503-l60cdllh 19 13 periphery periphery NN cord-298503-l60cdllh 19 14 and and CC cord-298503-l60cdllh 20 1 ER ER NNP cord-298503-l60cdllh 20 2 - - HYPH cord-298503-l60cdllh 20 3 Golgi Golgi NNP cord-298503-l60cdllh 20 4 trafficking trafficking NN cord-298503-l60cdllh 20 5 depends depend VBZ cord-298503-l60cdllh 20 6 on on IN cord-298503-l60cdllh 20 7 the the DT cord-298503-l60cdllh 20 8 long long JJ cord-298503-l60cdllh 20 9 distance distance NN cord-298503-l60cdllh 20 10 movements movement NNS cord-298503-l60cdllh 20 11 of of IN cord-298503-l60cdllh 20 12 the the DT cord-298503-l60cdllh 20 13 IC IC NNP cord-298503-l60cdllh 20 14 elements element NNS cord-298503-l60cdllh 20 15 along along IN cord-298503-l60cdllh 20 16 MT MT NNP cord-298503-l60cdllh 20 17 tracks track NNS cord-298503-l60cdllh 20 18 ( ( -LRB- cord-298503-l60cdllh 20 19 Saraste Saraste NNP cord-298503-l60cdllh 20 20 and and CC cord-298503-l60cdllh 20 21 Svensson Svensson NNP cord-298503-l60cdllh 20 22 , , , cord-298503-l60cdllh 20 23 1991 1991 CD cord-298503-l60cdllh 20 24 ; ; : cord-298503-l60cdllh 20 25 Presley Presley NNP cord-298503-l60cdllh 20 26 et et NNP cord-298503-l60cdllh 20 27 al al NNP cord-298503-l60cdllh 20 28 . . NNP cord-298503-l60cdllh 20 29 , , , cord-298503-l60cdllh 20 30 1997 1997 CD cord-298503-l60cdllh 20 31 ; ; . cord-298503-l60cdllh 21 1 Scales Scales NNP cord-298503-l60cdllh 21 2 et et NNP cord-298503-l60cdllh 21 3 al al NNP cord-298503-l60cdllh 21 4 . . NNP cord-298503-l60cdllh 21 5 , , , cord-298503-l60cdllh 21 6 1997 1997 CD cord-298503-l60cdllh 21 7 ; ; : cord-298503-l60cdllh 21 8 Brandizzi Brandizzi NNP cord-298503-l60cdllh 21 9 and and CC cord-298503-l60cdllh 21 10 Barlowe Barlowe NNP cord-298503-l60cdllh 21 11 , , , cord-298503-l60cdllh 21 12 2013 2013 CD cord-298503-l60cdllh 21 13 ; ; : cord-298503-l60cdllh 21 14 Day Day NNP cord-298503-l60cdllh 21 15 et et NNP cord-298503-l60cdllh 21 16 al al NNP cord-298503-l60cdllh 21 17 . . NNP cord-298503-l60cdllh 21 18 , , , cord-298503-l60cdllh 21 19 2013 2013 CD cord-298503-l60cdllh 21 20 ) ) -RRB- cord-298503-l60cdllh 21 21 . . . cord-298503-l60cdllh 22 1 Thus thus RB cord-298503-l60cdllh 22 2 , , , cord-298503-l60cdllh 22 3 it -PRON- PRP cord-298503-l60cdllh 22 4 has have VBZ cord-298503-l60cdllh 22 5 been be VBN cord-298503-l60cdllh 22 6 proposed propose VBN cord-298503-l60cdllh 22 7 that that IN cord-298503-l60cdllh 22 8 the the DT cord-298503-l60cdllh 22 9 IC IC NNP cord-298503-l60cdllh 22 10 represents represent VBZ cord-298503-l60cdllh 22 11 a a DT cord-298503-l60cdllh 22 12 late late JJ cord-298503-l60cdllh 22 13 evolutionary evolutionary JJ cord-298503-l60cdllh 22 14 invention invention NN cord-298503-l60cdllh 22 15 , , , cord-298503-l60cdllh 22 16 which which WDT cord-298503-l60cdllh 22 17 developed develop VBD cord-298503-l60cdllh 22 18 to to TO cord-298503-l60cdllh 22 19 meet meet VB cord-298503-l60cdllh 22 20 the the DT cord-298503-l60cdllh 22 21 special special JJ cord-298503-l60cdllh 22 22 sorting sorting NN cord-298503-l60cdllh 22 23 , , , cord-298503-l60cdllh 22 24 transport transport NN cord-298503-l60cdllh 22 25 and and CC cord-298503-l60cdllh 22 26 recycling recycling NN cord-298503-l60cdllh 22 27 requirements requirement NNS cord-298503-l60cdllh 22 28 of of IN cord-298503-l60cdllh 22 29 the the DT cord-298503-l60cdllh 22 30 large large JJ cord-298503-l60cdllh 22 31 - - HYPH cord-298503-l60cdllh 22 32 sized sized JJ cord-298503-l60cdllh 22 33 animal animal NN cord-298503-l60cdllh 22 34 cells cell NNS cord-298503-l60cdllh 22 35 , , , cord-298503-l60cdllh 22 36 but but CC cord-298503-l60cdllh 22 37 lacks lack VBZ cord-298503-l60cdllh 22 38 lower low JJR cord-298503-l60cdllh 22 39 eukaryotes eukaryote NNS cord-298503-l60cdllh 22 40 . . . cord-298503-l60cdllh 23 1 However however RB cord-298503-l60cdllh 23 2 , , , cord-298503-l60cdllh 23 3 results result NNS cord-298503-l60cdllh 23 4 showing show VBG cord-298503-l60cdllh 23 5 that that IN cord-298503-l60cdllh 23 6 the the DT cord-298503-l60cdllh 23 7 IC IC NNP cord-298503-l60cdllh 23 8 constitutes constitute VBZ cord-298503-l60cdllh 23 9 an an DT cord-298503-l60cdllh 23 10 extensive extensive JJ cord-298503-l60cdllh 23 11 membrane membrane NN cord-298503-l60cdllh 23 12 system system NN cord-298503-l60cdllh 23 13 that that WDT cord-298503-l60cdllh 23 14 can can MD cord-298503-l60cdllh 23 15 be be VB cord-298503-l60cdllh 23 16 compared compare VBN cord-298503-l60cdllh 23 17 with with IN cord-298503-l60cdllh 23 18 the the DT cord-298503-l60cdllh 23 19 endosomal endosomal NNP cord-298503-l60cdllh 23 20 network network NN cord-298503-l60cdllh 23 21 in in IN cord-298503-l60cdllh 23 22 complexity complexity NN cord-298503-l60cdllh 23 23 , , , cord-298503-l60cdllh 23 24 are be VBP cord-298503-l60cdllh 23 25 questioning question VBG cord-298503-l60cdllh 23 26 this this DT cord-298503-l60cdllh 23 27 view view NN cord-298503-l60cdllh 23 28 . . . cord-298503-l60cdllh 24 1 Electron electron NN cord-298503-l60cdllh 24 2 microscopic microscopic JJ cord-298503-l60cdllh 24 3 ( ( -LRB- cord-298503-l60cdllh 24 4 EM EM NNP cord-298503-l60cdllh 24 5 ) ) -RRB- cord-298503-l60cdllh 24 6 studies study NNS cord-298503-l60cdllh 24 7 using use VBG cord-298503-l60cdllh 24 8 a a DT cord-298503-l60cdllh 24 9 temperature temperature NN cord-298503-l60cdllh 24 10 - - HYPH cord-298503-l60cdllh 24 11 sensitive sensitive JJ cord-298503-l60cdllh 24 12 mutant mutant NN cord-298503-l60cdllh 24 13 of of IN cord-298503-l60cdllh 24 14 Semliki Semliki NNP cord-298503-l60cdllh 24 15 Forest Forest NNP cord-298503-l60cdllh 24 16 virus virus NN cord-298503-l60cdllh 24 17 ( ( -LRB- cord-298503-l60cdllh 24 18 SFV SFV NNP cord-298503-l60cdllh 24 19 ts-1 ts-1 NNP cord-298503-l60cdllh 24 20 ) ) -RRB- cord-298503-l60cdllh 24 21 to to TO cord-298503-l60cdllh 24 22 synchronize synchronize VB cord-298503-l60cdllh 24 23 the the DT cord-298503-l60cdllh 24 24 transport transport NN cord-298503-l60cdllh 24 25 of of IN cord-298503-l60cdllh 24 26 viral viral JJ cord-298503-l60cdllh 24 27 membrane membrane NN cord-298503-l60cdllh 24 28 glycoproteins glycoprotein NNS cord-298503-l60cdllh 24 29 from from IN cord-298503-l60cdllh 24 30 ER ER NNP cord-298503-l60cdllh 24 31 to to IN cord-298503-l60cdllh 24 32 the the DT cord-298503-l60cdllh 24 33 plasma plasma NN cord-298503-l60cdllh 24 34 membrane membrane NN cord-298503-l60cdllh 24 35 ( ( -LRB- cord-298503-l60cdllh 24 36 PM PM NNP cord-298503-l60cdllh 24 37 ) ) -RRB- cord-298503-l60cdllh 24 38 showed show VBD cord-298503-l60cdllh 24 39 that that IN cord-298503-l60cdllh 24 40 when when WRB cord-298503-l60cdllh 24 41 the the DT cord-298503-l60cdllh 24 42 cells cell NNS cord-298503-l60cdllh 24 43 are be VBP cord-298503-l60cdllh 24 44 shifted shift VBN cord-298503-l60cdllh 24 45 from from IN cord-298503-l60cdllh 24 46 39 39 CD cord-298503-l60cdllh 24 47 1C 1c NN cord-298503-l60cdllh 24 48 to to IN cord-298503-l60cdllh 24 49 15 15 CD cord-298503-l60cdllh 24 50 1C 1c NN cord-298503-l60cdllh 24 51 the the DT cord-298503-l60cdllh 24 52 proteins protein NNS cord-298503-l60cdllh 24 53 exit exit VBP cord-298503-l60cdllh 24 54 the the DT cord-298503-l60cdllh 24 55 ER er NN cord-298503-l60cdllh 24 56 , , , cord-298503-l60cdllh 24 57 but but CC cord-298503-l60cdllh 24 58 accumulate accumulate VBP cord-298503-l60cdllh 24 59 in in IN cord-298503-l60cdllh 24 60 vacuoles vacuole NNS cord-298503-l60cdllh 24 61 / / SYM cord-298503-l60cdllh 24 62 saccules saccule NNS cord-298503-l60cdllh 24 63 ( ( -LRB- cord-298503-l60cdllh 24 64 up up IN cord-298503-l60cdllh 24 65 to to TO cord-298503-l60cdllh 24 66 0.5 0.5 CD cord-298503-l60cdllh 24 67 mm mm NNS cord-298503-l60cdllh 24 68 in in IN cord-298503-l60cdllh 24 69 diameter diameter NN cord-298503-l60cdllh 24 70 ) ) -RRB- cord-298503-l60cdllh 24 71 , , , cord-298503-l60cdllh 24 72 tubules tubule NNS cord-298503-l60cdllh 24 73 , , , cord-298503-l60cdllh 24 74 and and CC cord-298503-l60cdllh 24 75 vesicles vesicle NNS cord-298503-l60cdllh 24 76 in in IN cord-298503-l60cdllh 24 77 the the DT cord-298503-l60cdllh 24 78 cis cis NNP cord-298503-l60cdllh 24 79 - - HYPH cord-298503-l60cdllh 24 80 Golgi Golgi NNP cord-298503-l60cdllh 24 81 region region NN cord-298503-l60cdllh 24 82 and and CC cord-298503-l60cdllh 24 83 more more JJR cord-298503-l60cdllh 24 84 peripheral peripheral JJ cord-298503-l60cdllh 24 85 locations location NNS cord-298503-l60cdllh 24 86 ( ( -LRB- cord-298503-l60cdllh 24 87 Saraste Saraste NNP cord-298503-l60cdllh 24 88 and and CC cord-298503-l60cdllh 24 89 Kuismanen Kuismanen NNP cord-298503-l60cdllh 24 90 , , , cord-298503-l60cdllh 24 91 1984 1984 CD cord-298503-l60cdllh 24 92 ) ) -RRB- cord-298503-l60cdllh 24 93 . . . cord-298503-l60cdllh 25 1 By by IN cord-298503-l60cdllh 25 2 light light JJ cord-298503-l60cdllh 25 3 microscopy microscopy NNS cord-298503-l60cdllh 25 4 ( ( -LRB- cord-298503-l60cdllh 25 5 LM LM NNP cord-298503-l60cdllh 25 6 ) ) -RRB- cord-298503-l60cdllh 25 7 the the DT cord-298503-l60cdllh 25 8 proteins protein NNS cord-298503-l60cdllh 25 9 were be VBD cord-298503-l60cdllh 25 10 localized localize VBN cord-298503-l60cdllh 25 11 at at IN cord-298503-l60cdllh 25 12 15 15 CD cord-298503-l60cdllh 25 13 1C 1c NN cord-298503-l60cdllh 25 14 to to IN cord-298503-l60cdllh 25 15 scattered scatter VBN cord-298503-l60cdllh 25 16 globular globular JJ cord-298503-l60cdllh 25 17 structures structure NNS cord-298503-l60cdllh 25 18 in in IN cord-298503-l60cdllh 25 19 the the DT cord-298503-l60cdllh 25 20 cytoplasm cytoplasm NN cord-298503-l60cdllh 25 21 , , , cord-298503-l60cdllh 25 22 a a DT cord-298503-l60cdllh 25 23 pattern pattern NN cord-298503-l60cdllh 25 24 distinct distinct JJ cord-298503-l60cdllh 25 25 from from IN cord-298503-l60cdllh 25 26 that that DT cord-298503-l60cdllh 25 27 of of IN cord-298503-l60cdllh 25 28 ER ER NNP cord-298503-l60cdllh 25 29 or or CC cord-298503-l60cdllh 25 30 Golgi Golgi NNP cord-298503-l60cdllh 25 31 ( ( -LRB- cord-298503-l60cdllh 25 32 Kuismanen Kuismanen NNP cord-298503-l60cdllh 25 33 and and CC cord-298503-l60cdllh 25 34 Saraste Saraste NNP cord-298503-l60cdllh 25 35 , , , cord-298503-l60cdllh 25 36 1989 1989 CD cord-298503-l60cdllh 25 37 ) ) -RRB- cord-298503-l60cdllh 25 38 . . . cord-298503-l60cdllh 26 1 The the DT cord-298503-l60cdllh 26 2 transport transport NN cord-298503-l60cdllh 26 3 block block NN cord-298503-l60cdllh 26 4 was be VBD cord-298503-l60cdllh 26 5 readily readily RB cord-298503-l60cdllh 26 6 reversible reversible JJ cord-298503-l60cdllh 26 7 , , , cord-298503-l60cdllh 26 8 and and CC cord-298503-l60cdllh 26 9 the the DT cord-298503-l60cdllh 26 10 proteins protein NNS cord-298503-l60cdllh 26 11 entered enter VBD cord-298503-l60cdllh 26 12 the the DT cord-298503-l60cdllh 26 13 Golgi Golgi NNP cord-298503-l60cdllh 26 14 stacks stack NNS cord-298503-l60cdllh 26 15 and and CC cord-298503-l60cdllh 26 16 reached reach VBD cord-298503-l60cdllh 26 17 the the DT cord-298503-l60cdllh 26 18 PM pm NN cord-298503-l60cdllh 26 19 following follow VBG cord-298503-l60cdllh 26 20 the the DT cord-298503-l60cdllh 26 21 transfer transfer NN cord-298503-l60cdllh 26 22 of of IN cord-298503-l60cdllh 26 23 cells cell NNS cord-298503-l60cdllh 26 24 from from IN cord-298503-l60cdllh 26 25 15 15 CD cord-298503-l60cdllh 26 26 1C 1c CD cord-298503-l60cdllh 26 27 to to IN cord-298503-l60cdllh 26 28 28 28 CD cord-298503-l60cdllh 26 29 1C 1c NN cord-298503-l60cdllh 26 30 , , , cord-298503-l60cdllh 26 31 showing show VBG cord-298503-l60cdllh 26 32 that that IN cord-298503-l60cdllh 26 33 these these DT cord-298503-l60cdllh 26 34 structures structure NNS cord-298503-l60cdllh 26 35 are be VBP cord-298503-l60cdllh 26 36 normal normal JJ cord-298503-l60cdllh 26 37 transport transport NN cord-298503-l60cdllh 26 38 intermediates intermediate NNS cord-298503-l60cdllh 26 39 . . . cord-298503-l60cdllh 27 1 Studies study NNS cord-298503-l60cdllh 27 2 employing employ VBG cord-298503-l60cdllh 27 3 a a DT cord-298503-l60cdllh 27 4 similar similar JJ cord-298503-l60cdllh 27 5 mutant mutant NN cord-298503-l60cdllh 27 6 of of IN cord-298503-l60cdllh 27 7 vesicular vesicular JJ cord-298503-l60cdllh 27 8 stomatitis stomatitis NN cord-298503-l60cdllh 27 9 virus virus NN cord-298503-l60cdllh 27 10 ( ( -LRB- cord-298503-l60cdllh 27 11 VSV VSV NNP cord-298503-l60cdllh 27 12 tsO45 tsO45 NNP cord-298503-l60cdllh 27 13 ) ) -RRB- cord-298503-l60cdllh 27 14 showed show VBD cord-298503-l60cdllh 27 15 that that IN cord-298503-l60cdllh 27 16 the the DT cord-298503-l60cdllh 27 17 ' ' CD cord-298503-l60cdllh 27 18 15 15 CD cord-298503-l60cdllh 27 19 1C 1C NNP cord-298503-l60cdllh 27 20 compartment compartment NNP cord-298503-l60cdllh 27 21 ' ' '' cord-298503-l60cdllh 27 22 also also RB cord-298503-l60cdllh 27 23 acts act VBZ cord-298503-l60cdllh 27 24 as as IN cord-298503-l60cdllh 27 25 a a DT cord-298503-l60cdllh 27 26 way way NN cord-298503-l60cdllh 27 27 station station NN cord-298503-l60cdllh 27 28 during during IN cord-298503-l60cdllh 27 29 the the DT cord-298503-l60cdllh 27 30 transport transport NN cord-298503-l60cdllh 27 31 of of IN cord-298503-l60cdllh 27 32 the the DT cord-298503-l60cdllh 27 33 VSV VSV NNP cord-298503-l60cdllh 27 34 G G NNP cord-298503-l60cdllh 27 35 glycoprotein glycoprotein NN cord-298503-l60cdllh 27 36 ( ( -LRB- cord-298503-l60cdllh 27 37 Balch Balch NNP cord-298503-l60cdllh 27 38 et et NNP cord-298503-l60cdllh 27 39 al al NNP cord-298503-l60cdllh 27 40 . . NNP cord-298503-l60cdllh 27 41 , , , cord-298503-l60cdllh 27 42 1986 1986 CD cord-298503-l60cdllh 27 43 ; ; : cord-298503-l60cdllh 27 44 Bonatti Bonatti NNP cord-298503-l60cdllh 27 45 et et NNP cord-298503-l60cdllh 27 46 al al NNP cord-298503-l60cdllh 27 47 . . NNP cord-298503-l60cdllh 27 48 , , , cord-298503-l60cdllh 27 49 1989 1989 CD cord-298503-l60cdllh 27 50 ; ; : cord-298503-l60cdllh 27 51 Schweizer Schweizer NNP cord-298503-l60cdllh 27 52 et et NNP cord-298503-l60cdllh 27 53 al al NNP cord-298503-l60cdllh 27 54 . . NNP cord-298503-l60cdllh 27 55 , , , cord-298503-l60cdllh 27 56 1990 1990 CD cord-298503-l60cdllh 27 57 ; ; : cord-298503-l60cdllh 27 58 Duden Duden NNP cord-298503-l60cdllh 27 59 et et NNP cord-298503-l60cdllh 27 60 al al NNP cord-298503-l60cdllh 27 61 . . NNP cord-298503-l60cdllh 27 62 , , , cord-298503-l60cdllh 27 63 1991 1991 CD cord-298503-l60cdllh 27 64 ; ; : cord-298503-l60cdllh 27 65 Lotti Lotti NNP cord-298503-l60cdllh 27 66 et et NNP cord-298503-l60cdllh 27 67 al al NNP cord-298503-l60cdllh 27 68 . . NNP cord-298503-l60cdllh 27 69 , , , cord-298503-l60cdllh 27 70 1992 1992 CD cord-298503-l60cdllh 27 71 ) ) -RRB- cord-298503-l60cdllh 27 72 . . . cord-298503-l60cdllh 28 1 Like like IN cord-298503-l60cdllh 28 2 the the DT cord-298503-l60cdllh 28 3 SFV sfv NN cord-298503-l60cdllh 28 4 proteins protein NNS cord-298503-l60cdllh 28 5 , , , cord-298503-l60cdllh 28 6 the the DT cord-298503-l60cdllh 28 7 G g NN cord-298503-l60cdllh 28 8 - - HYPH cord-298503-l60cdllh 28 9 protein protein NN cord-298503-l60cdllh 28 10 was be VBD cord-298503-l60cdllh 28 11 found find VBN cord-298503-l60cdllh 28 12 to to TO cord-298503-l60cdllh 28 13 maintain maintain VB cord-298503-l60cdllh 28 14 its -PRON- PRP$ cord-298503-l60cdllh 28 15 ER er NN cord-298503-l60cdllh 28 16 - - HYPH cord-298503-l60cdllh 28 17 type type NN cord-298503-l60cdllh 28 18 high high JJ cord-298503-l60cdllh 28 19 - - HYPH cord-298503-l60cdllh 28 20 mannose mannose NN cord-298503-l60cdllh 28 21 glycans glycan NNS cord-298503-l60cdllh 28 22 at at IN cord-298503-l60cdllh 28 23 15 15 CD cord-298503-l60cdllh 28 24 1C 1c NN cord-298503-l60cdllh 28 25 , , , cord-298503-l60cdllh 28 26 indicating indicate VBG cord-298503-l60cdllh 28 27 lack lack NN cord-298503-l60cdllh 28 28 of of IN cord-298503-l60cdllh 28 29 processing processing NN cord-298503-l60cdllh 28 30 by by IN cord-298503-l60cdllh 28 31 Golgi Golgi NNP cord-298503-l60cdllh 28 32 enzymes enzyme NNS cord-298503-l60cdllh 28 33 . . . cord-298503-l60cdllh 29 1 Furthermore furthermore RB cord-298503-l60cdllh 29 2 , , , cord-298503-l60cdllh 29 3 cell cell NN cord-298503-l60cdllh 29 4 fractionation fractionation NN cord-298503-l60cdllh 29 5 experiments experiment NNS cord-298503-l60cdllh 29 6 showed show VBD cord-298503-l60cdllh 29 7 that that IN cord-298503-l60cdllh 29 8 newly newly RB cord-298503-l60cdllh 29 9 synthesized synthesize VBN cord-298503-l60cdllh 29 10 secretory secretory JJ cord-298503-l60cdllh 29 11 proteins protein NNS cord-298503-l60cdllh 29 12 are be VBP cord-298503-l60cdllh 29 13 arrested arrest VBN cord-298503-l60cdllh 29 14 in in IN cord-298503-l60cdllh 29 15 a a DT cord-298503-l60cdllh 29 16 post post JJ cord-298503-l60cdllh 29 17 - - JJ cord-298503-l60cdllh 29 18 ER er JJ cord-298503-l60cdllh 29 19 location location NN cord-298503-l60cdllh 29 20 when when WRB cord-298503-l60cdllh 29 21 pancreatic pancreatic JJ cord-298503-l60cdllh 29 22 exocrine exocrine JJ cord-298503-l60cdllh 29 23 cells cell NNS cord-298503-l60cdllh 29 24 are be VBP cord-298503-l60cdllh 29 25 kept keep VBN cord-298503-l60cdllh 29 26 at at IN cord-298503-l60cdllh 29 27 16 16 CD cord-298503-l60cdllh 29 28 1C 1c NN cord-298503-l60cdllh 29 29 ( ( -LRB- cord-298503-l60cdllh 29 30 Saraste Saraste NNP cord-298503-l60cdllh 29 31 et et NNP cord-298503-l60cdllh 29 32 al al NNP cord-298503-l60cdllh 29 33 . . NNP cord-298503-l60cdllh 29 34 , , , cord-298503-l60cdllh 29 35 1986 1986 CD cord-298503-l60cdllh 29 36 ) ) -RRB- cord-298503-l60cdllh 29 37 . . . cord-298503-l60cdllh 30 1 Live live JJ cord-298503-l60cdllh 30 2 cell cell NN cord-298503-l60cdllh 30 3 imaging imaging NN cord-298503-l60cdllh 30 4 of of IN cord-298503-l60cdllh 30 5 green green JJ cord-298503-l60cdllh 30 6 fluorescent fluorescent NN cord-298503-l60cdllh 30 7 protein protein NN cord-298503-l60cdllh 30 8 ( ( -LRB- cord-298503-l60cdllh 30 9 GFP GFP NNP cord-298503-l60cdllh 30 10 ) ) -RRB- cord-298503-l60cdllh 30 11 equipped equip VBN cord-298503-l60cdllh 30 12 with with IN cord-298503-l60cdllh 30 13 an an DT cord-298503-l60cdllh 30 14 ER ER NNP cord-298503-l60cdllh 30 15 targeting targeting NN cord-298503-l60cdllh 30 16 signal signal NN cord-298503-l60cdllh 30 17 ( ( -LRB- cord-298503-l60cdllh 30 18 ssGFP ssgfp UH cord-298503-l60cdllh 30 19 ) ) -RRB- cord-298503-l60cdllh 30 20 and and CC cord-298503-l60cdllh 30 21 EM EM NNP cord-298503-l60cdllh 30 22 studies study NNS cord-298503-l60cdllh 30 23 of of IN cord-298503-l60cdllh 30 24 procollagen procollagen NNP cord-298503-l60cdllh 30 25 and and CC cord-298503-l60cdllh 30 26 growth growth NN cord-298503-l60cdllh 30 27 hormone hormone NN cord-298503-l60cdllh 30 28 constructs construct NNS cord-298503-l60cdllh 30 29 verified verify VBN cord-298503-l60cdllh 30 30 that that IN cord-298503-l60cdllh 30 31 the the DT cord-298503-l60cdllh 30 32 transport transport NN cord-298503-l60cdllh 30 33 of of IN cord-298503-l60cdllh 30 34 membrane membrane NN cord-298503-l60cdllh 30 35 and and CC cord-298503-l60cdllh 30 36 secretory secretory NN cord-298503-l60cdllh 30 37 proteins protein NNS cord-298503-l60cdllh 30 38 is be VBZ cord-298503-l60cdllh 30 39 similarly similarly RB cord-298503-l60cdllh 30 40 affected affect VBN cord-298503-l60cdllh 30 41 at at IN cord-298503-l60cdllh 30 42 15 15 CD cord-298503-l60cdllh 30 43 - - SYM cord-298503-l60cdllh 30 44 16 16 CD cord-298503-l60cdllh 30 45 1C 1c NN cord-298503-l60cdllh 30 46 ( ( -LRB- cord-298503-l60cdllh 30 47 Blum Blum NNP cord-298503-l60cdllh 30 48 et et NNP cord-298503-l60cdllh 30 49 al al NNP cord-298503-l60cdllh 30 50 . . . cord-298503-l60cdllh 31 1 , , , cord-298503-l60cdllh 31 2 2000 2000 CD cord-298503-l60cdllh 31 3 ; ; : cord-298503-l60cdllh 31 4 Volchuk Volchuk NNP cord-298503-l60cdllh 31 5 et et NNP cord-298503-l60cdllh 31 6 al al NNP cord-298503-l60cdllh 31 7 . . . cord-298503-l60cdllh 32 1 , , , cord-298503-l60cdllh 32 2 2000 2000 CD cord-298503-l60cdllh 32 3 ; ; : cord-298503-l60cdllh 32 4 Trucco Trucco NNP cord-298503-l60cdllh 32 5 et et FW cord-298503-l60cdllh 32 6 al al NNP cord-298503-l60cdllh 32 7 . . NNP cord-298503-l60cdllh 32 8 , , , cord-298503-l60cdllh 32 9 2004 2004 CD cord-298503-l60cdllh 32 10 ) ) -RRB- cord-298503-l60cdllh 32 11 . . . cord-298503-l60cdllh 33 1 In in IN cord-298503-l60cdllh 33 2 addition addition NN cord-298503-l60cdllh 33 3 , , , cord-298503-l60cdllh 33 4 the the DT cord-298503-l60cdllh 33 5 transport transport NN cord-298503-l60cdllh 33 6 of of IN cord-298503-l60cdllh 33 7 virus virus NN cord-298503-l60cdllh 33 8 glycoproteins glycoprotein NNS cord-298503-l60cdllh 33 9 and and CC cord-298503-l60cdllh 33 10 cholesterol cholesterol NN cord-298503-l60cdllh 33 11 appears appear VBZ cord-298503-l60cdllh 33 12 to to TO cord-298503-l60cdllh 33 13 be be VB cord-298503-l60cdllh 33 14 blocked block VBN cord-298503-l60cdllh 33 15 at at IN cord-298503-l60cdllh 33 16 the the DT cord-298503-l60cdllh 33 17 same same JJ cord-298503-l60cdllh 33 18 site site NN cord-298503-l60cdllh 33 19 at at IN cord-298503-l60cdllh 33 20 this this DT cord-298503-l60cdllh 33 21 temperature temperature NN cord-298503-l60cdllh 33 22 ( ( -LRB- cord-298503-l60cdllh 33 23 Urbani Urbani NNP cord-298503-l60cdllh 33 24 and and CC cord-298503-l60cdllh 33 25 Simoni Simoni NNP cord-298503-l60cdllh 33 26 , , , cord-298503-l60cdllh 33 27 1990 1990 CD cord-298503-l60cdllh 33 28 ; ; : cord-298503-l60cdllh 33 29 Heino Heino NNP cord-298503-l60cdllh 33 30 et et NNP cord-298503-l60cdllh 33 31 al al NNP cord-298503-l60cdllh 33 32 . . . cord-298503-l60cdllh 33 33 2000 2000 CD cord-298503-l60cdllh 33 34 ) ) -RRB- cord-298503-l60cdllh 33 35 . . . cord-298503-l60cdllh 34 1 EM EM NNP cord-298503-l60cdllh 34 2 of of IN cord-298503-l60cdllh 34 3 mouse mouse NN cord-298503-l60cdllh 34 4 hepatitis hepatitis NN cord-298503-l60cdllh 34 5 virus virus NN cord-298503-l60cdllh 34 6 ( ( -LRB- cord-298503-l60cdllh 34 7 MHV)-infected mhv)-infected JJ cord-298503-l60cdllh 34 8 cells cell NNS cord-298503-l60cdllh 34 9 showed show VBD cord-298503-l60cdllh 34 10 that that IN cord-298503-l60cdllh 34 11 the the DT cord-298503-l60cdllh 34 12 budding budding NN cord-298503-l60cdllh 34 13 of of IN cord-298503-l60cdllh 34 14 progeny progeny JJ cord-298503-l60cdllh 34 15 virus virus NN cord-298503-l60cdllh 34 16 initially initially RB cord-298503-l60cdllh 34 17 takes take VBZ cord-298503-l60cdllh 34 18 place place NN cord-298503-l60cdllh 34 19 at at IN cord-298503-l60cdllh 34 20 tubulovesicular tubulovesicular NNP cord-298503-l60cdllh 34 21 membranes membrane NNS cord-298503-l60cdllh 34 22 located locate VBN cord-298503-l60cdllh 34 23 in in IN cord-298503-l60cdllh 34 24 the the DT cord-298503-l60cdllh 34 25 transitional transitional JJ cord-298503-l60cdllh 34 26 region region NN cord-298503-l60cdllh 34 27 between between IN cord-298503-l60cdllh 34 28 the the DT cord-298503-l60cdllh 34 29 ER ER NNP cord-298503-l60cdllh 34 30 and and CC cord-298503-l60cdllh 34 31 the the DT cord-298503-l60cdllh 34 32 Golgi Golgi NNP cord-298503-l60cdllh 34 33 apparatus apparatus NN cord-298503-l60cdllh 35 1 ( ( -LRB- cord-298503-l60cdllh 35 2 Tooze Tooze NNP cord-298503-l60cdllh 35 3 et et NNP cord-298503-l60cdllh 35 4 al al NNP cord-298503-l60cdllh 35 5 . . NNP cord-298503-l60cdllh 35 6 , , , cord-298503-l60cdllh 35 7 1984 1984 CD cord-298503-l60cdllh 35 8 ) ) -RRB- cord-298503-l60cdllh 35 9 . . . cord-298503-l60cdllh 36 1 The the DT cord-298503-l60cdllh 36 2 first first JJ cord-298503-l60cdllh 36 3 step step NN cord-298503-l60cdllh 36 4 of of IN cord-298503-l60cdllh 36 5 O o NN cord-298503-l60cdllh 36 6 - - HYPH cord-298503-l60cdllh 36 7 glycosylation glycosylation NN cord-298503-l60cdllh 36 8 , , , cord-298503-l60cdllh 36 9 the the DT cord-298503-l60cdllh 36 10 attachment attachment NN cord-298503-l60cdllh 36 11 of of IN cord-298503-l60cdllh 36 12 Nacetyl Nacetyl NNP cord-298503-l60cdllh 36 13 - - HYPH cord-298503-l60cdllh 36 14 galactosamine galactosamine NNP cord-298503-l60cdllh 36 15 ( ( -LRB- cord-298503-l60cdllh 36 16 GalNAc GalNAc NNP cord-298503-l60cdllh 36 17 ) ) -RRB- cord-298503-l60cdllh 36 18 to to IN cord-298503-l60cdllh 36 19 the the DT cord-298503-l60cdllh 36 20 viral viral JJ cord-298503-l60cdllh 36 21 membrane membrane NN cord-298503-l60cdllh 36 22 ( ( -LRB- cord-298503-l60cdllh 36 23 M M NNP cord-298503-l60cdllh 36 24 ) ) -RRB- cord-298503-l60cdllh 36 25 glycoprotein glycoprotein NN cord-298503-l60cdllh 36 26 , , , cord-298503-l60cdllh 36 27 was be VBD cord-298503-l60cdllh 36 28 suggested suggest VBN cord-298503-l60cdllh 36 29 to to TO cord-298503-l60cdllh 36 30 occur occur VB cord-298503-l60cdllh 36 31 in in IN cord-298503-l60cdllh 36 32 this this DT cord-298503-l60cdllh 36 33 compartment compartment NN cord-298503-l60cdllh 36 34 , , , cord-298503-l60cdllh 36 35 causing cause VBG cord-298503-l60cdllh 36 36 its -PRON- PRP$ cord-298503-l60cdllh 36 37 reactivity reactivity NN cord-298503-l60cdllh 36 38 with with IN cord-298503-l60cdllh 36 39 the the DT cord-298503-l60cdllh 36 40 lectin lectin NN cord-298503-l60cdllh 36 41 Helix Helix NNP cord-298503-l60cdllh 36 42 pomatia pomatia NN cord-298503-l60cdllh 36 43 , , , cord-298503-l60cdllh 36 44 which which WDT cord-298503-l60cdllh 36 45 specifically specifically RB cord-298503-l60cdllh 36 46 binds bind VBZ cord-298503-l60cdllh 36 47 GalNAc GalNAc NNP cord-298503-l60cdllh 36 48 ( ( -LRB- cord-298503-l60cdllh 36 49 Tooze Tooze NNP cord-298503-l60cdllh 36 50 et et NNP cord-298503-l60cdllh 36 51 al al NNP cord-298503-l60cdllh 36 52 . . NNP cord-298503-l60cdllh 36 53 , , , cord-298503-l60cdllh 36 54 1988 1988 CD cord-298503-l60cdllh 36 55 ; ; : cord-298503-l60cdllh 36 56 Krijnse Krijnse NNP cord-298503-l60cdllh 36 57 - - HYPH cord-298503-l60cdllh 36 58 Locker Locker NNP cord-298503-l60cdllh 36 59 et et FW cord-298503-l60cdllh 36 60 al al NNP cord-298503-l60cdllh 36 61 . . NNP cord-298503-l60cdllh 36 62 , , , cord-298503-l60cdllh 36 63 1994 1994 CD cord-298503-l60cdllh 36 64 ) ) -RRB- cord-298503-l60cdllh 36 65 . . . cord-298503-l60cdllh 37 1 Subsequent subsequent JJ cord-298503-l60cdllh 37 2 studies study NNS cord-298503-l60cdllh 37 3 showed show VBD cord-298503-l60cdllh 37 4 that that IN cord-298503-l60cdllh 37 5 the the DT cord-298503-l60cdllh 37 6 intracellular intracellular JJ cord-298503-l60cdllh 37 7 maturation maturation NN cord-298503-l60cdllh 37 8 of of IN cord-298503-l60cdllh 37 9 various various JJ cord-298503-l60cdllh 37 10 coronaviruses coronaviruse NNS cord-298503-l60cdllh 37 11 occurs occur VBZ cord-298503-l60cdllh 37 12 at at IN cord-298503-l60cdllh 37 13 the the DT cord-298503-l60cdllh 37 14 same same JJ cord-298503-l60cdllh 37 15 budding budding NN cord-298503-l60cdllh 37 16 site site NN cord-298503-l60cdllh 37 17 , , , cord-298503-l60cdllh 37 18 which which WDT cord-298503-l60cdllh 37 19 corresponds correspond VBZ cord-298503-l60cdllh 37 20 to to IN cord-298503-l60cdllh 37 21 the the DT cord-298503-l60cdllh 37 22 IC IC NNP cord-298503-l60cdllh 37 23 ( ( -LRB- cord-298503-l60cdllh 37 24 Klumperman Klumperman NNP cord-298503-l60cdllh 37 25 et et FW cord-298503-l60cdllh 37 26 al al NNP cord-298503-l60cdllh 37 27 . . NNP cord-298503-l60cdllh 37 28 , , , cord-298503-l60cdllh 37 29 1994 1994 CD cord-298503-l60cdllh 37 30 ) ) -RRB- cord-298503-l60cdllh 37 31 . . . cord-298503-l60cdllh 38 1 The the DT cord-298503-l60cdllh 38 2 discovery discovery NN cord-298503-l60cdllh 38 3 of of IN cord-298503-l60cdllh 38 4 the the DT cord-298503-l60cdllh 38 5 lys lys NNP cord-298503-l60cdllh 38 6 - - HYPH cord-298503-l60cdllh 38 7 asp asp NNP cord-298503-l60cdllh 38 8 - - HYPH cord-298503-l60cdllh 38 9 glu glu NNP cord-298503-l60cdllh 38 10 - - HYPH cord-298503-l60cdllh 38 11 leu leu NNP cord-298503-l60cdllh 38 12 tetra tetra NNP cord-298503-l60cdllh 38 13 - - HYPH cord-298503-l60cdllh 38 14 peptide peptide NN cord-298503-l60cdllh 38 15 ( ( -LRB- cord-298503-l60cdllh 38 16 KDEL)motif kdel)motif XX cord-298503-l60cdllh 38 17 in in IN cord-298503-l60cdllh 38 18 abundant abundant JJ cord-298503-l60cdllh 38 19 , , , cord-298503-l60cdllh 38 20 lumenal lumenal JJ cord-298503-l60cdllh 38 21 ER ER NNP cord-298503-l60cdllh 38 22 proteins protein NNS cord-298503-l60cdllh 38 23 lead lead VBP cord-298503-l60cdllh 38 24 to to IN cord-298503-l60cdllh 38 25 the the DT cord-298503-l60cdllh 38 26 proposal proposal NN cord-298503-l60cdllh 38 27 that that IN cord-298503-l60cdllh 38 28 the the DT cord-298503-l60cdllh 38 29 15 15 CD cord-298503-l60cdllh 38 30 1C 1C NNP cord-298503-l60cdllh 38 31 / / SYM cord-298503-l60cdllh 38 32 budding bud VBG cord-298503-l60cdllh 38 33 compartment compartment NN cord-298503-l60cdllh 38 34 is be VBZ cord-298503-l60cdllh 38 35 the the DT cord-298503-l60cdllh 38 36 post post JJ cord-298503-l60cdllh 38 37 - - JJ cord-298503-l60cdllh 38 38 ER er JJ cord-298503-l60cdllh 38 39 site site NN cord-298503-l60cdllh 38 40 from from IN cord-298503-l60cdllh 38 41 which which WDT cord-298503-l60cdllh 38 42 these these DT cord-298503-l60cdllh 38 43 proteins protein NNS cord-298503-l60cdllh 38 44 are be VBP cord-298503-l60cdllh 38 45 retrieved retrieve VBN cord-298503-l60cdllh 38 46 to to IN cord-298503-l60cdllh 38 47 the the DT cord-298503-l60cdllh 38 48 ER ER NNP cord-298503-l60cdllh 38 49 ( ( -LRB- cord-298503-l60cdllh 38 50 Munro Munro NNP cord-298503-l60cdllh 38 51 and and CC cord-298503-l60cdllh 38 52 Pelham Pelham NNP cord-298503-l60cdllh 38 53 , , , cord-298503-l60cdllh 38 54 1987 1987 CD cord-298503-l60cdllh 38 55 ; ; : cord-298503-l60cdllh 38 56 Warren Warren NNP cord-298503-l60cdllh 38 57 , , , cord-298503-l60cdllh 38 58 1987 1987 CD cord-298503-l60cdllh 38 59 ; ; : cord-298503-l60cdllh 38 60 Pelham Pelham NNP cord-298503-l60cdllh 38 61 , , , cord-298503-l60cdllh 38 62 1989 1989 CD cord-298503-l60cdllh 38 63 ) ) -RRB- cord-298503-l60cdllh 38 64 . . . cord-298503-l60cdllh 39 1 The the DT cord-298503-l60cdllh 39 2 first first JJ cord-298503-l60cdllh 39 3 mammalian mammalian JJ cord-298503-l60cdllh 39 4 KDEL KDEL NNP cord-298503-l60cdllh 39 5 - - HYPH cord-298503-l60cdllh 39 6 receptor receptor NN cord-298503-l60cdllh 39 7 , , , cord-298503-l60cdllh 39 8 a a DT cord-298503-l60cdllh 39 9 multispanning multispanne VBG cord-298503-l60cdllh 39 10 membrane membrane NN cord-298503-l60cdllh 39 11 protein protein NN cord-298503-l60cdllh 39 12 , , , cord-298503-l60cdllh 39 13 was be VBD cord-298503-l60cdllh 39 14 identified identify VBN cord-298503-l60cdllh 39 15 and and CC cord-298503-l60cdllh 39 16 shown show VBN cord-298503-l60cdllh 39 17 to to TO cord-298503-l60cdllh 39 18 predominantly predominantly RB cord-298503-l60cdllh 39 19 localize localize VB cord-298503-l60cdllh 39 20 to to IN cord-298503-l60cdllh 39 21 the the DT cord-298503-l60cdllh 39 22 IC IC NNP cord-298503-l60cdllh 39 23 and and CC cord-298503-l60cdllh 39 24 cis cis NNP cord-298503-l60cdllh 39 25 - - HYPH cord-298503-l60cdllh 39 26 Golgi Golgi NNP cord-298503-l60cdllh 39 27 ( ( -LRB- cord-298503-l60cdllh 39 28 Lewis Lewis NNP cord-298503-l60cdllh 39 29 and and CC cord-298503-l60cdllh 39 30 Pelham Pelham NNP cord-298503-l60cdllh 39 31 , , , cord-298503-l60cdllh 39 32 1990 1990 CD cord-298503-l60cdllh 39 33 ; ; : cord-298503-l60cdllh 39 34 Tang Tang NNP cord-298503-l60cdllh 39 35 et et NNP cord-298503-l60cdllh 39 36 al al NNP cord-298503-l60cdllh 39 37 . . NNP cord-298503-l60cdllh 39 38 , , , cord-298503-l60cdllh 39 39 1993 1993 CD cord-298503-l60cdllh 39 40 ; ; : cord-298503-l60cdllh 39 41 Griffiths Griffiths NNP cord-298503-l60cdllh 39 42 et et NNP cord-298503-l60cdllh 39 43 al al NNP cord-298503-l60cdllh 39 44 . . . cord-298503-l60cdllh 40 1 , , , cord-298503-l60cdllh 40 2 1994 1994 CD cord-298503-l60cdllh 40 3 ; ; : cord-298503-l60cdllh 40 4 Orci Orci NNP cord-298503-l60cdllh 40 5 et et NNP cord-298503-l60cdllh 40 6 al al NNP cord-298503-l60cdllh 40 7 . . NNP cord-298503-l60cdllh 40 8 , , , cord-298503-l60cdllh 40 9 1997 1997 CD cord-298503-l60cdllh 40 10 ) ) -RRB- cord-298503-l60cdllh 40 11 . . . cord-298503-l60cdllh 41 1 Also also RB cord-298503-l60cdllh 41 2 , , , cord-298503-l60cdllh 41 3 KDEL KDEL NNP cord-298503-l60cdllh 41 4 proteins protein NNS cord-298503-l60cdllh 41 5 , , , cord-298503-l60cdllh 41 6 such such JJ cord-298503-l60cdllh 41 7 as as IN cord-298503-l60cdllh 41 8 the the DT cord-298503-l60cdllh 41 9 immunoglobulin immunoglobulin NN cord-298503-l60cdllh 41 10 binding bind VBG cord-298503-l60cdllh 41 11 protein protein NN cord-298503-l60cdllh 41 12 ( ( -LRB- cord-298503-l60cdllh 41 13 BiP BiP NNP cord-298503-l60cdllh 41 14 / / , cord-298503-l60cdllh 41 15 GRP78 GRP78 NNP cord-298503-l60cdllh 41 16 ) ) -RRB- cord-298503-l60cdllh 41 17 , , , cord-298503-l60cdllh 41 18 glucoseregulated glucoseregulate VBN cord-298503-l60cdllh 41 19 protein protein NN cord-298503-l60cdllh 41 20 of of IN cord-298503-l60cdllh 41 21 94 94 CD cord-298503-l60cdllh 41 22 kDa kDa NNPS cord-298503-l60cdllh 41 23 ( ( -LRB- cord-298503-l60cdllh 41 24 GRP94 GRP94 NNP cord-298503-l60cdllh 41 25 ) ) -RRB- cord-298503-l60cdllh 41 26 , , , cord-298503-l60cdllh 41 27 protein protein NN cord-298503-l60cdllh 41 28 disulphide disulphide NN cord-298503-l60cdllh 41 29 isomerase isomerase NN cord-298503-l60cdllh 41 30 ( ( -LRB- cord-298503-l60cdllh 41 31 PDI PDI NNP cord-298503-l60cdllh 41 32 ) ) -RRB- cord-298503-l60cdllh 41 33 and and CC cord-298503-l60cdllh 41 34 calreticulin calreticulin NNP cord-298503-l60cdllh 41 35 ( ( -LRB- cord-298503-l60cdllh 41 36 CR CR NNP cord-298503-l60cdllh 41 37 ) ) -RRB- cord-298503-l60cdllh 41 38 , , , cord-298503-l60cdllh 41 39 are be VBP cord-298503-l60cdllh 41 40 present present JJ cord-298503-l60cdllh 41 41 in in IN cord-298503-l60cdllh 41 42 the the DT cord-298503-l60cdllh 41 43 IC IC NNP cord-298503-l60cdllh 41 44 Connolly Connolly NNP cord-298503-l60cdllh 41 45 et et NNP cord-298503-l60cdllh 41 46 al al NNP cord-298503-l60cdllh 41 47 . . . cord-298503-l60cdllh 42 1 , , , cord-298503-l60cdllh 42 2 1994 1994 CD cord-298503-l60cdllh 42 3 ; ; : cord-298503-l60cdllh 42 4 Zuber Zuber NNP cord-298503-l60cdllh 42 5 et et NNP cord-298503-l60cdllh 42 6 al al NNP cord-298503-l60cdllh 42 7 . . . cord-298503-l60cdllh 43 1 , , , cord-298503-l60cdllh 43 2 2001 2001 CD cord-298503-l60cdllh 43 3 ; ; : cord-298503-l60cdllh 43 4 Ying Ying NNP cord-298503-l60cdllh 43 5 et et FW cord-298503-l60cdllh 43 6 al al NNP cord-298503-l60cdllh 43 7 . . . cord-298503-l60cdllh 44 1 , , , cord-298503-l60cdllh 44 2 2002 2002 CD cord-298503-l60cdllh 44 3 ; ; : cord-298503-l60cdllh 44 4 Breuza Breuza NNP cord-298503-l60cdllh 44 5 et et NNP cord-298503-l60cdllh 44 6 al al NNP cord-298503-l60cdllh 44 7 . . NNP cord-298503-l60cdllh 44 8 , , , cord-298503-l60cdllh 44 9 2004 2004 CD cord-298503-l60cdllh 44 10 ) ) -RRB- cord-298503-l60cdllh 44 11 . . . cord-298503-l60cdllh 45 1 Following follow VBG cord-298503-l60cdllh 45 2 binding bind VBG cord-298503-l60cdllh 45 3 to to IN cord-298503-l60cdllh 45 4 their -PRON- PRP$ cord-298503-l60cdllh 45 5 receptor receptor NN cord-298503-l60cdllh 45 6 , , , cord-298503-l60cdllh 45 7 the the DT cord-298503-l60cdllh 45 8 proteins protein NNS cord-298503-l60cdllh 45 9 are be VBP cord-298503-l60cdllh 45 10 retrieved retrieve VBN cord-298503-l60cdllh 45 11 to to IN cord-298503-l60cdllh 45 12 the the DT cord-298503-l60cdllh 45 13 ER ER NNP cord-298503-l60cdllh 45 14 in in IN cord-298503-l60cdllh 45 15 COPI COPI NNP cord-298503-l60cdllh 45 16 vesicles vesicle NNS cord-298503-l60cdllh 45 17 ( ( -LRB- cord-298503-l60cdllh 45 18 Orci Orci NNP cord-298503-l60cdllh 45 19 et et NNP cord-298503-l60cdllh 45 20 al al NNP cord-298503-l60cdllh 45 21 . . NNP cord-298503-l60cdllh 45 22 , , , cord-298503-l60cdllh 45 23 1997 1997 CD cord-298503-l60cdllh 45 24 ; ; : cord-298503-l60cdllh 45 25 Martínez Martínez NNP cord-298503-l60cdllh 45 26 - - HYPH cord-298503-l60cdllh 45 27 Menárguez Menárguez NNP cord-298503-l60cdllh 45 28 et et NNP cord-298503-l60cdllh 45 29 al al NNP cord-298503-l60cdllh 45 30 . . NNP cord-298503-l60cdllh 45 31 , , , cord-298503-l60cdllh 45 32 1999 1999 CD cord-298503-l60cdllh 45 33 ; ; : cord-298503-l60cdllh 45 34 Majoul Majoul NNP cord-298503-l60cdllh 45 35 et et FW cord-298503-l60cdllh 45 36 al al NNP cord-298503-l60cdllh 45 37 . . NNP cord-298503-l60cdllh 45 38 , , , cord-298503-l60cdllh 45 39 2001 2001 CD cord-298503-l60cdllh 45 40 ) ) -RRB- cord-298503-l60cdllh 45 41 . . . cord-298503-l60cdllh 46 1 Attachment attachment NN cord-298503-l60cdllh 46 2 of of IN cord-298503-l60cdllh 46 3 the the DT cord-298503-l60cdllh 46 4 KDEL KDEL NNP cord-298503-l60cdllh 46 5 - - HYPH cord-298503-l60cdllh 46 6 motif motif NN cord-298503-l60cdllh 46 7 to to IN cord-298503-l60cdllh 46 8 lysosomal lysosomal JJ cord-298503-l60cdllh 46 9 enzymes enzyme NNS cord-298503-l60cdllh 46 10 and and CC cord-298503-l60cdllh 46 11 the the DT cord-298503-l60cdllh 46 12 use use NN cord-298503-l60cdllh 46 13 of of IN cord-298503-l60cdllh 46 14 the the DT cord-298503-l60cdllh 46 15 15 15 CD cord-298503-l60cdllh 46 16 1C 1C NNP cord-298503-l60cdllh 46 17 block block NN cord-298503-l60cdllh 46 18 suggested suggest VBD cord-298503-l60cdllh 46 19 that that IN cord-298503-l60cdllh 46 20 the the DT cord-298503-l60cdllh 46 21 enzyme enzyme NN cord-298503-l60cdllh 46 22 that that WDT cord-298503-l60cdllh 46 23 initiates initiate VBZ cord-298503-l60cdllh 46 24 the the DT cord-298503-l60cdllh 46 25 formation formation NN cord-298503-l60cdllh 46 26 of of IN cord-298503-l60cdllh 46 27 their -PRON- PRP$ cord-298503-l60cdllh 46 28 lysosomal lysosomal JJ cord-298503-l60cdllh 46 29 targeting targeting NN cord-298503-l60cdllh 46 30 signal signal NN cord-298503-l60cdllh 46 31 ( ( -LRB- cord-298503-l60cdllh 46 32 mannose-6-phosphate mannose-6-phosphate NNP cord-298503-l60cdllh 46 33 ) ) -RRB- cord-298503-l60cdllh 46 34 resides reside VBZ cord-298503-l60cdllh 46 35 in in IN cord-298503-l60cdllh 46 36 the the DT cord-298503-l60cdllh 46 37 IC IC NNP cord-298503-l60cdllh 46 38 ( ( -LRB- cord-298503-l60cdllh 46 39 Pelham Pelham NNP cord-298503-l60cdllh 46 40 , , , cord-298503-l60cdllh 46 41 1988 1988 CD cord-298503-l60cdllh 46 42 ; ; . cord-298503-l60cdllh 47 1 Lazzarino Lazzarino NNP cord-298503-l60cdllh 47 2 and and CC cord-298503-l60cdllh 47 3 Gabel Gabel NNP cord-298503-l60cdllh 47 4 , , , cord-298503-l60cdllh 47 5 1988 1988 CD cord-298503-l60cdllh 47 6 ; ; : cord-298503-l60cdllh 47 7 Dittmer Dittmer NNP cord-298503-l60cdllh 47 8 and and CC cord-298503-l60cdllh 47 9 von von NNP cord-298503-l60cdllh 47 10 Figura Figura NNP cord-298503-l60cdllh 47 11 , , , cord-298503-l60cdllh 47 12 1999 1999 CD cord-298503-l60cdllh 47 13 ) ) -RRB- cord-298503-l60cdllh 47 14 . . . cord-298503-l60cdllh 48 1 The the DT cord-298503-l60cdllh 48 2 cytoplasmic cytoplasmic JJ cord-298503-l60cdllh 48 3 tails tail NNS cord-298503-l60cdllh 48 4 of of IN cord-298503-l60cdllh 48 5 certain certain JJ cord-298503-l60cdllh 48 6 type type NN cord-298503-l60cdllh 48 7 I -PRON- PRP cord-298503-l60cdllh 48 8 integral integral JJ cord-298503-l60cdllh 48 9 membrane membrane NN cord-298503-l60cdllh 48 10 proteins protein NNS cord-298503-l60cdllh 48 11 were be VBD cord-298503-l60cdllh 48 12 shown show VBN cord-298503-l60cdllh 48 13 to to TO cord-298503-l60cdllh 48 14 contain contain VB cord-298503-l60cdllh 48 15 dilysine dilysine NN cord-298503-l60cdllh 48 16 ( ( -LRB- cord-298503-l60cdllh 48 17 KKXX)motifs KKXX)motifs NNP cord-298503-l60cdllh 48 18 , , , cord-298503-l60cdllh 48 19 which which WDT cord-298503-l60cdllh 48 20 by by IN cord-298503-l60cdllh 48 21 directly directly RB cord-298503-l60cdllh 48 22 interacting interact VBG cord-298503-l60cdllh 48 23 with with IN cord-298503-l60cdllh 48 24 COPI COPI NNP cord-298503-l60cdllh 48 25 coats coat NNS cord-298503-l60cdllh 48 26 result result VBP cord-298503-l60cdllh 48 27 in in IN cord-298503-l60cdllh 48 28 their -PRON- PRP$ cord-298503-l60cdllh 48 29 retrieval retrieval NN cord-298503-l60cdllh 48 30 from from IN cord-298503-l60cdllh 48 31 the the DT cord-298503-l60cdllh 48 32 IC IC NNP cord-298503-l60cdllh 48 33 / / SYM cord-298503-l60cdllh 48 34 cis cis NNP cord-298503-l60cdllh 48 35 - - HYPH cord-298503-l60cdllh 48 36 Golgi Golgi NNP cord-298503-l60cdllh 48 37 to to IN cord-298503-l60cdllh 48 38 the the DT cord-298503-l60cdllh 48 39 ER er NN cord-298503-l60cdllh 49 1 ( ( -LRB- cord-298503-l60cdllh 49 2 Nilsson Nilsson NNP cord-298503-l60cdllh 49 3 et et NNP cord-298503-l60cdllh 49 4 al al NNP cord-298503-l60cdllh 49 5 . . NNP cord-298503-l60cdllh 49 6 , , , cord-298503-l60cdllh 49 7 1989 1989 CD cord-298503-l60cdllh 49 8 ; ; : cord-298503-l60cdllh 49 9 Jackson Jackson NNP cord-298503-l60cdllh 49 10 et et NNP cord-298503-l60cdllh 49 11 al al NNP cord-298503-l60cdllh 49 12 . . . cord-298503-l60cdllh 50 1 , , , cord-298503-l60cdllh 50 2 1990 1990 CD cord-298503-l60cdllh 50 3 Jackson Jackson NNP cord-298503-l60cdllh 50 4 et et NNP cord-298503-l60cdllh 50 5 al al NNP cord-298503-l60cdllh 50 6 . . . cord-298503-l60cdllh 51 1 , , , cord-298503-l60cdllh 51 2 , , , cord-298503-l60cdllh 51 3 1993 1993 CD cord-298503-l60cdllh 51 4 Cosson Cosson NNP cord-298503-l60cdllh 51 5 and and CC cord-298503-l60cdllh 51 6 Letourneur Letourneur NNP cord-298503-l60cdllh 51 7 , , , cord-298503-l60cdllh 51 8 1997 1997 CD cord-298503-l60cdllh 51 9 ) ) -RRB- cord-298503-l60cdllh 51 10 . . . cord-298503-l60cdllh 52 1 The the DT cord-298503-l60cdllh 52 2 first first JJ cord-298503-l60cdllh 52 3 endogenous endogenous JJ cord-298503-l60cdllh 52 4 IC IC NNP cord-298503-l60cdllh 52 5 markers marker NNS cord-298503-l60cdllh 52 6 rat rat NN cord-298503-l60cdllh 52 7 p58 p58 NN cord-298503-l60cdllh 52 8 and and CC cord-298503-l60cdllh 52 9 human human JJ cord-298503-l60cdllh 52 10 ER ER NNP cord-298503-l60cdllh 52 11 - - HYPH cord-298503-l60cdllh 52 12 Golgi Golgi NNP cord-298503-l60cdllh 52 13 intermediate intermediate JJ cord-298503-l60cdllh 52 14 compartment compartment NN cord-298503-l60cdllh 53 1 ( ( -LRB- cord-298503-l60cdllh 53 2 ERGIC)-53 ERGIC)-53 NNP cord-298503-l60cdllh 53 3 ( ( -LRB- cord-298503-l60cdllh 53 4 89 89 CD cord-298503-l60cdllh 53 5 % % NN cord-298503-l60cdllh 53 6 homology homology NN cord-298503-l60cdllh 53 7 ) ) -RRB- cord-298503-l60cdllh 53 8 were be VBD cord-298503-l60cdllh 53 9 identified identify VBN cord-298503-l60cdllh 53 10 by by IN cord-298503-l60cdllh 53 11 the the DT cord-298503-l60cdllh 53 12 generation generation NN cord-298503-l60cdllh 53 13 of of IN cord-298503-l60cdllh 53 14 antibodies antibody NNS cord-298503-l60cdllh 53 15 against against IN cord-298503-l60cdllh 53 16 the the DT cord-298503-l60cdllh 53 17 16 16 CD cord-298503-l60cdllh 53 18 1C 1c NN cord-298503-l60cdllh 53 19 post post NN cord-298503-l60cdllh 53 20 - - JJ cord-298503-l60cdllh 53 21 ER er JJ cord-298503-l60cdllh 53 22 fraction fraction NN cord-298503-l60cdllh 53 23 isolated isolate VBN cord-298503-l60cdllh 53 24 from from IN cord-298503-l60cdllh 53 25 pancreatic pancreatic JJ cord-298503-l60cdllh 53 26 acinar acinar NN cord-298503-l60cdllh 53 27 cells cell NNS cord-298503-l60cdllh 53 28 ( ( -LRB- cord-298503-l60cdllh 53 29 Saraste Saraste NNP cord-298503-l60cdllh 53 30 et et NNP cord-298503-l60cdllh 53 31 al al NNP cord-298503-l60cdllh 53 32 . . NNP cord-298503-l60cdllh 53 33 , , , cord-298503-l60cdllh 53 34 1987 1987 CD cord-298503-l60cdllh 53 35 ) ) -RRB- cord-298503-l60cdllh 53 36 and and CC cord-298503-l60cdllh 53 37 a a DT cord-298503-l60cdllh 53 38 Golgi Golgi NNP cord-298503-l60cdllh 53 39 fraction fraction NN cord-298503-l60cdllh 53 40 derived derive VBN cord-298503-l60cdllh 53 41 from from IN cord-298503-l60cdllh 53 42 epithelial epithelial JJ cord-298503-l60cdllh 53 43 Caco-2 Caco-2 NNP cord-298503-l60cdllh 53 44 cells cell NNS cord-298503-l60cdllh 53 45 ( ( -LRB- cord-298503-l60cdllh 53 46 Schweizer Schweizer NNP cord-298503-l60cdllh 53 47 et et NNP cord-298503-l60cdllh 53 48 al al NNP cord-298503-l60cdllh 53 49 . . NNP cord-298503-l60cdllh 53 50 , , , cord-298503-l60cdllh 53 51 1988 1988 CD cord-298503-l60cdllh 53 52 ) ) -RRB- cord-298503-l60cdllh 53 53 , , , cord-298503-l60cdllh 53 54 respectively respectively RB cord-298503-l60cdllh 53 55 . . . cord-298503-l60cdllh 54 1 The the DT cord-298503-l60cdllh 54 2 cytoplasmic cytoplasmic JJ cord-298503-l60cdllh 54 3 C c NN cord-298503-l60cdllh 54 4 - - HYPH cord-298503-l60cdllh 54 5 terminal terminal NN cord-298503-l60cdllh 54 6 tails tail NNS cord-298503-l60cdllh 54 7 of of IN cord-298503-l60cdllh 54 8 these these DT cord-298503-l60cdllh 54 9 non non JJ cord-298503-l60cdllh 54 10 - - JJ cord-298503-l60cdllh 54 11 glycosylated glycosylated JJ cord-298503-l60cdllh 54 12 , , , cord-298503-l60cdllh 54 13 hexameric hexameric NN cord-298503-l60cdllh 54 14 , , , cord-298503-l60cdllh 54 15 type-1 type-1 NN cord-298503-l60cdllh 54 16 integral integral JJ cord-298503-l60cdllh 54 17 membrane membrane NN cord-298503-l60cdllh 54 18 proteins protein NNS cord-298503-l60cdllh 55 1 ( ( -LRB- cord-298503-l60cdllh 55 2 Schindler Schindler NNP cord-298503-l60cdllh 55 3 et et NNP cord-298503-l60cdllh 55 4 al al NNP cord-298503-l60cdllh 55 5 . . . cord-298503-l60cdllh 56 1 , , , cord-298503-l60cdllh 56 2 1993 1993 CD cord-298503-l60cdllh 56 3 ; ; : cord-298503-l60cdllh 56 4 Lahtinen Lahtinen NNP cord-298503-l60cdllh 56 5 et et NNP cord-298503-l60cdllh 56 6 al al NNP cord-298503-l60cdllh 56 7 . . NNP cord-298503-l60cdllh 56 8 , , , cord-298503-l60cdllh 56 9 1992 1992 CD cord-298503-l60cdllh 57 1 Lahtinen Lahtinen NNP cord-298503-l60cdllh 57 2 et et NNP cord-298503-l60cdllh 57 3 al al NNP cord-298503-l60cdllh 57 4 . . . cord-298503-l60cdllh 58 1 , , , cord-298503-l60cdllh 58 2 , , , cord-298503-l60cdllh 58 3 1996 1996 CD cord-298503-l60cdllh 58 4 Neve Neve NNP cord-298503-l60cdllh 58 5 et et NNP cord-298503-l60cdllh 58 6 al al NNP cord-298503-l60cdllh 58 7 . . NNP cord-298503-l60cdllh 58 8 , , , cord-298503-l60cdllh 58 9 2005 2005 CD cord-298503-l60cdllh 58 10 ) ) -RRB- cord-298503-l60cdllh 58 11 contain contain VBP cord-298503-l60cdllh 58 12 a a DT cord-298503-l60cdllh 58 13 KKFF KKFF NNP cord-298503-l60cdllh 58 14 - - HYPH cord-298503-l60cdllh 58 15 motif motif NN cord-298503-l60cdllh 58 16 , , , cord-298503-l60cdllh 58 17 which which WDT cord-298503-l60cdllh 58 18 interacts interact VBZ cord-298503-l60cdllh 58 19 with with IN cord-298503-l60cdllh 58 20 COPII COPII NNP cord-298503-l60cdllh 58 21 and and CC cord-298503-l60cdllh 58 22 COPI COPI NNP cord-298503-l60cdllh 58 23 coats coat NNS cord-298503-l60cdllh 58 24 and and CC cord-298503-l60cdllh 58 25 gives give VBZ cord-298503-l60cdllh 58 26 rise rise NN cord-298503-l60cdllh 58 27 to to IN cord-298503-l60cdllh 58 28 their -PRON- PRP$ cord-298503-l60cdllh 58 29 continuous continuous JJ cord-298503-l60cdllh 58 30 cycling cycling NN cord-298503-l60cdllh 58 31 between between IN cord-298503-l60cdllh 58 32 ER ER NNP cord-298503-l60cdllh 58 33 , , , cord-298503-l60cdllh 58 34 IC IC NNP cord-298503-l60cdllh 58 35 , , , cord-298503-l60cdllh 58 36 and and CC cord-298503-l60cdllh 58 37 cis cis NNP cord-298503-l60cdllh 58 38 - - HYPH cord-298503-l60cdllh 58 39 Golgi Golgi NNP cord-298503-l60cdllh 59 1 ( ( -LRB- cord-298503-l60cdllh 59 2 Kappeler Kappeler NNP cord-298503-l60cdllh 59 3 et et NNP cord-298503-l60cdllh 59 4 al al NNP cord-298503-l60cdllh 59 5 . . NNP cord-298503-l60cdllh 59 6 , , , cord-298503-l60cdllh 59 7 1997 1997 CD cord-298503-l60cdllh 60 1 ; ; : cord-298503-l60cdllh 60 2 Tisdale Tisdale NNP cord-298503-l60cdllh 60 3 et et NNP cord-298503-l60cdllh 60 4 al al NNP cord-298503-l60cdllh 60 5 . . NNP cord-298503-l60cdllh 60 6 , , , cord-298503-l60cdllh 60 7 1997 1997 CD cord-298503-l60cdllh 60 8 ) ) -RRB- cord-298503-l60cdllh 60 9 . . . cord-298503-l60cdllh 61 1 At at IN cord-298503-l60cdllh 61 2 15 15 CD cord-298503-l60cdllh 61 3 1C 1c NN cord-298503-l60cdllh 61 4 the the DT cord-298503-l60cdllh 61 5 recycling recycling NN cord-298503-l60cdllh 61 6 of of IN cord-298503-l60cdllh 61 7 p58 p58 NNP cord-298503-l60cdllh 61 8 / / SYM cord-298503-l60cdllh 61 9 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 61 10 to to IN cord-298503-l60cdllh 61 11 the the DT cord-298503-l60cdllh 61 12 ER ER NNP cord-298503-l60cdllh 61 13 is be VBZ cord-298503-l60cdllh 61 14 inhibited inhibit VBN cord-298503-l60cdllh 61 15 and and CC cord-298503-l60cdllh 61 16 the the DT cord-298503-l60cdllh 61 17 proteins protein NNS cord-298503-l60cdllh 61 18 pile pile VBP cord-298503-l60cdllh 61 19 up up RP cord-298503-l60cdllh 61 20 in in IN cord-298503-l60cdllh 61 21 the the DT cord-298503-l60cdllh 61 22 same same JJ cord-298503-l60cdllh 61 23 pre pre JJ cord-298503-l60cdllh 61 24 - - JJ cord-298503-l60cdllh 61 25 Golgi golgi JJ cord-298503-l60cdllh 61 26 structures structure NNS cord-298503-l60cdllh 61 27 that that WDT cord-298503-l60cdllh 61 28 contain contain VBP cord-298503-l60cdllh 61 29 the the DT cord-298503-l60cdllh 61 30 SFV SFV NNP cord-298503-l60cdllh 61 31 or or CC cord-298503-l60cdllh 61 32 VSV VSV NNP cord-298503-l60cdllh 61 33 membrane membrane NN cord-298503-l60cdllh 61 34 proteins protein NNS cord-298503-l60cdllh 61 35 Saraste Saraste NNP cord-298503-l60cdllh 61 36 and and CC cord-298503-l60cdllh 61 37 Svensson Svensson NNP cord-298503-l60cdllh 61 38 , , , cord-298503-l60cdllh 61 39 1991 1991 CD cord-298503-l60cdllh 61 40 ; ; : cord-298503-l60cdllh 61 41 Plutner Plutner NNP cord-298503-l60cdllh 61 42 et et NNP cord-298503-l60cdllh 61 43 al al NNP cord-298503-l60cdllh 61 44 . . NNP cord-298503-l60cdllh 61 45 , , , cord-298503-l60cdllh 61 46 1992 1992 CD cord-298503-l60cdllh 61 47 ) ) -RRB- cord-298503-l60cdllh 61 48 , , , cord-298503-l60cdllh 61 49 verifying verify VBG cord-298503-l60cdllh 61 50 that that IN cord-298503-l60cdllh 61 51 the the DT cord-298503-l60cdllh 61 52 p58 p58 NNP cord-298503-l60cdllh 61 53 / / SYM cord-298503-l60cdllh 61 54 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 61 55 compartment compartment NN cord-298503-l60cdllh 61 56 ( ( -LRB- cord-298503-l60cdllh 61 57 Figures figure NNS cord-298503-l60cdllh 61 58 1 1 CD cord-298503-l60cdllh 61 59 and and CC cord-298503-l60cdllh 61 60 4 4 LS cord-298503-l60cdllh 61 61 ) ) -RRB- cord-298503-l60cdllh 61 62 is be VBZ cord-298503-l60cdllh 61 63 equivalent equivalent JJ cord-298503-l60cdllh 61 64 to to IN cord-298503-l60cdllh 61 65 the the DT cord-298503-l60cdllh 61 66 site site NN cord-298503-l60cdllh 61 67 where where WRB cord-298503-l60cdllh 61 68 cargo cargo NN cord-298503-l60cdllh 61 69 is be VBZ cord-298503-l60cdllh 61 70 arrested arrest VBN cord-298503-l60cdllh 61 71 at at IN cord-298503-l60cdllh 61 72 low low JJ cord-298503-l60cdllh 61 73 temperature temperature NN cord-298503-l60cdllh 61 74 . . . cord-298503-l60cdllh 62 1 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 62 2 and and CC cord-298503-l60cdllh 62 3 the the DT cord-298503-l60cdllh 62 4 related relate VBN cord-298503-l60cdllh 62 5 VIP36 VIP36 NNP cord-298503-l60cdllh 62 6 were be VBD cord-298503-l60cdllh 62 7 shown show VBN cord-298503-l60cdllh 62 8 to to TO cord-298503-l60cdllh 62 9 share share VB cord-298503-l60cdllh 62 10 homology homology NN cord-298503-l60cdllh 62 11 with with IN cord-298503-l60cdllh 62 12 leguminous leguminous JJ cord-298503-l60cdllh 62 13 plant plant NN cord-298503-l60cdllh 62 14 lectins lectin NNS cord-298503-l60cdllh 62 15 ( ( -LRB- cord-298503-l60cdllh 62 16 Fiedler Fiedler NNP cord-298503-l60cdllh 62 17 and and CC cord-298503-l60cdllh 62 18 Simons Simons NNP cord-298503-l60cdllh 62 19 , , , cord-298503-l60cdllh 62 20 1994 1994 CD cord-298503-l60cdllh 62 21 ) ) -RRB- cord-298503-l60cdllh 62 22 and and CC cord-298503-l60cdllh 62 23 to to TO cord-298503-l60cdllh 62 24 be be VB cord-298503-l60cdllh 62 25 identical identical JJ cord-298503-l60cdllh 62 26 with with IN cord-298503-l60cdllh 62 27 a a DT cord-298503-l60cdllh 62 28 mannose mannose NN cord-298503-l60cdllh 62 29 - - HYPH cord-298503-l60cdllh 62 30 binding bind VBG cord-298503-l60cdllh 62 31 protein protein NN cord-298503-l60cdllh 62 32 MR60 MR60 NNP cord-298503-l60cdllh 62 33 of of IN cord-298503-l60cdllh 62 34 human human JJ cord-298503-l60cdllh 62 35 myelomonocytic myelomonocytic NN cord-298503-l60cdllh 62 36 ( ( -LRB- cord-298503-l60cdllh 62 37 HL60 HL60 NNP cord-298503-l60cdllh 62 38 ) ) -RRB- cord-298503-l60cdllh 62 39 cells cell NNS cord-298503-l60cdllh 62 40 ( ( -LRB- cord-298503-l60cdllh 62 41 Arar Arar NNP cord-298503-l60cdllh 62 42 et et FW cord-298503-l60cdllh 62 43 al al NNP cord-298503-l60cdllh 62 44 . . NNP cord-298503-l60cdllh 62 45 , , , cord-298503-l60cdllh 62 46 1995 1995 CD cord-298503-l60cdllh 62 47 ) ) -RRB- cord-298503-l60cdllh 62 48 . . . cord-298503-l60cdllh 63 1 The the DT cord-298503-l60cdllh 63 2 N n CD cord-298503-l60cdllh 63 3 - - HYPH cord-298503-l60cdllh 63 4 terminal terminal NN cord-298503-l60cdllh 63 5 domain domain NN cord-298503-l60cdllh 63 6 of of IN cord-298503-l60cdllh 63 7 p58 p58 NNP cord-298503-l60cdllh 63 8 / / SYM cord-298503-l60cdllh 63 9 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 63 10 binds bind VBZ cord-298503-l60cdllh 63 11 mannose mannose NN cord-298503-l60cdllh 63 12 in in IN cord-298503-l60cdllh 63 13 a a DT cord-298503-l60cdllh 63 14 calcium calcium NN cord-298503-l60cdllh 63 15 - - HYPH cord-298503-l60cdllh 63 16 dependent dependent JJ cord-298503-l60cdllh 63 17 manner manner NN cord-298503-l60cdllh 64 1 ( ( -LRB- cord-298503-l60cdllh 64 2 Itin Itin NNP cord-298503-l60cdllh 64 3 et et NNP cord-298503-l60cdllh 64 4 al al NNP cord-298503-l60cdllh 64 5 . . NNP cord-298503-l60cdllh 64 6 , , , cord-298503-l60cdllh 64 7 1996 1996 CD cord-298503-l60cdllh 64 8 ; ; : cord-298503-l60cdllh 64 9 Velloso Velloso NNP cord-298503-l60cdllh 64 10 et et NNP cord-298503-l60cdllh 64 11 al al NNP cord-298503-l60cdllh 64 12 . . NNP cord-298503-l60cdllh 64 13 , , , cord-298503-l60cdllh 64 14 2003 2003 CD cord-298503-l60cdllh 64 15 ; ; : cord-298503-l60cdllh 64 16 ; ; : cord-298503-l60cdllh 64 17 hence hence RB cord-298503-l60cdllh 64 18 the the DT cord-298503-l60cdllh 64 19 name name NN cord-298503-l60cdllh 64 20 lectin lectin NN cord-298503-l60cdllh 64 21 mannose mannose NN cord-298503-l60cdllh 64 22 - - HYPH cord-298503-l60cdllh 64 23 binding bind VBG cord-298503-l60cdllh 64 24 protein protein NN cord-298503-l60cdllh 64 25 1 1 CD cord-298503-l60cdllh 64 26 ( ( -LRB- cord-298503-l60cdllh 64 27 LMAN1 lman1 NN cord-298503-l60cdllh 64 28 ) ) -RRB- cord-298503-l60cdllh 64 29 . . . cord-298503-l60cdllh 65 1 It -PRON- PRP cord-298503-l60cdllh 65 2 is be VBZ cord-298503-l60cdllh 65 3 the the DT cord-298503-l60cdllh 65 4 best well RBS cord-298503-l60cdllh 65 5 characterized characterize VBN cord-298503-l60cdllh 65 6 mammalian mammalian JJ cord-298503-l60cdllh 65 7 cargo cargo NN cord-298503-l60cdllh 65 8 receptor receptor NN cord-298503-l60cdllh 65 9 , , , cord-298503-l60cdllh 65 10 facilitating facilitate VBG cord-298503-l60cdllh 65 11 the the DT cord-298503-l60cdllh 65 12 COPII COPII NNP cord-298503-l60cdllh 65 13 vesicle vesicle NN cord-298503-l60cdllh 65 14 - - HYPH cord-298503-l60cdllh 65 15 mediated mediate VBN cord-298503-l60cdllh 65 16 export export NN cord-298503-l60cdllh 65 17 of of IN cord-298503-l60cdllh 65 18 a a DT cord-298503-l60cdllh 65 19 subset subset NN cord-298503-l60cdllh 65 20 of of IN cord-298503-l60cdllh 65 21 soluble soluble JJ cord-298503-l60cdllh 65 22 glycoproteins glycoprotein NNS cord-298503-l60cdllh 65 23 from from IN cord-298503-l60cdllh 65 24 the the DT cord-298503-l60cdllh 65 25 ER ER NNP cord-298503-l60cdllh 66 1 ( ( -LRB- cord-298503-l60cdllh 66 2 Nichols Nichols NNP cord-298503-l60cdllh 66 3 et et NNP cord-298503-l60cdllh 66 4 al al NNP cord-298503-l60cdllh 66 5 . . . cord-298503-l60cdllh 67 1 , , , cord-298503-l60cdllh 67 2 1998 1998 CD cord-298503-l60cdllh 67 3 ; ; : cord-298503-l60cdllh 67 4 Appenzeller Appenzeller NNP cord-298503-l60cdllh 67 5 et et NNP cord-298503-l60cdllh 67 6 al al NNP cord-298503-l60cdllh 67 7 . . . cord-298503-l60cdllh 68 1 , , , cord-298503-l60cdllh 68 2 1999 1999 CD cord-298503-l60cdllh 68 3 ; ; : cord-298503-l60cdllh 68 4 Hauri Hauri NNP cord-298503-l60cdllh 68 5 et et NNP cord-298503-l60cdllh 68 6 al al NNP cord-298503-l60cdllh 68 7 . . NNP cord-298503-l60cdllh 68 8 , , , cord-298503-l60cdllh 68 9 2000 2000 CD cord-298503-l60cdllh 68 10 ) ) -RRB- cord-298503-l60cdllh 68 11 . . . cord-298503-l60cdllh 69 1 Most most RBS cord-298503-l60cdllh 69 2 well well RB cord-298503-l60cdllh 69 3 - - HYPH cord-298503-l60cdllh 69 4 characterized characterize VBN cord-298503-l60cdllh 69 5 IC IC NNP cord-298503-l60cdllh 69 6 proteins protein NNS cord-298503-l60cdllh 69 7 are be VBP cord-298503-l60cdllh 69 8 components component NNS cord-298503-l60cdllh 69 9 of of IN cord-298503-l60cdllh 69 10 the the DT cord-298503-l60cdllh 69 11 transport transport NN cord-298503-l60cdllh 69 12 machinery machinery NN cord-298503-l60cdllh 69 13 . . . cord-298503-l60cdllh 70 1 Many many JJ cord-298503-l60cdllh 70 2 of of IN cord-298503-l60cdllh 70 3 them -PRON- PRP cord-298503-l60cdllh 70 4 cycle cycle VBP cord-298503-l60cdllh 70 5 at at IN cord-298503-l60cdllh 70 6 the the DT cord-298503-l60cdllh 70 7 ER ER NNP cord-298503-l60cdllh 70 8 - - HYPH cord-298503-l60cdllh 70 9 Golgi Golgi NNP cord-298503-l60cdllh 70 10 boundary boundary NN cord-298503-l60cdllh 70 11 and and CC cord-298503-l60cdllh 70 12 are be VBP cord-298503-l60cdllh 70 13 also also RB cord-298503-l60cdllh 70 14 found find VBN cord-298503-l60cdllh 70 15 in in IN cord-298503-l60cdllh 70 16 cis cis NNP cord-298503-l60cdllh 70 17 - - HYPH cord-298503-l60cdllh 70 18 Golgi Golgi NNP cord-298503-l60cdllh 70 19 , , , cord-298503-l60cdllh 70 20 supporting support VBG cord-298503-l60cdllh 70 21 the the DT cord-298503-l60cdllh 70 22 view view NN cord-298503-l60cdllh 70 23 of of IN cord-298503-l60cdllh 70 24 the the DT cord-298503-l60cdllh 70 25 IC IC NNP cord-298503-l60cdllh 70 26 as as IN cord-298503-l60cdllh 70 27 a a DT cord-298503-l60cdllh 70 28 transient transient JJ cord-298503-l60cdllh 70 29 structure structure NN cord-298503-l60cdllh 70 30 ( ( -LRB- cord-298503-l60cdllh 70 31 see see VB cord-298503-l60cdllh 70 32 below below RB cord-298503-l60cdllh 70 33 ) ) -RRB- cord-298503-l60cdllh 70 34 . . . cord-298503-l60cdllh 71 1 In in IN cord-298503-l60cdllh 71 2 fact fact NN cord-298503-l60cdllh 71 3 , , , cord-298503-l60cdllh 71 4 EM EM NNP cord-298503-l60cdllh 71 5 studies study NNS cord-298503-l60cdllh 71 6 showing show VBG cord-298503-l60cdllh 71 7 the the DT cord-298503-l60cdllh 71 8 specific specific JJ cord-298503-l60cdllh 71 9 metal metal NN cord-298503-l60cdllh 71 10 ( ( -LRB- cord-298503-l60cdllh 71 11 osmium osmium NN cord-298503-l60cdllh 71 12 ) ) -RRB- cord-298503-l60cdllh 71 13 staining staining NN cord-298503-l60cdllh 71 14 of of IN cord-298503-l60cdllh 71 15 the the DT cord-298503-l60cdllh 71 16 IC IC NNP cord-298503-l60cdllh 71 17 and and CC cord-298503-l60cdllh 71 18 cis cis NNP cord-298503-l60cdllh 71 19 - - HYPH cord-298503-l60cdllh 71 20 Golgi Golgi NNP cord-298503-l60cdllh 71 21 provided provide VBD cord-298503-l60cdllh 71 22 the the DT cord-298503-l60cdllh 71 23 first first JJ cord-298503-l60cdllh 71 24 indication indication NN cord-298503-l60cdllh 71 25 of of IN cord-298503-l60cdllh 71 26 their -PRON- PRP$ cord-298503-l60cdllh 71 27 compositional compositional JJ cord-298503-l60cdllh 71 28 similarity similarity NN cord-298503-l60cdllh 71 29 ( ( -LRB- cord-298503-l60cdllh 71 30 Friend friend NN cord-298503-l60cdllh 71 31 and and CC cord-298503-l60cdllh 71 32 Murray Murray NNP cord-298503-l60cdllh 71 33 , , , cord-298503-l60cdllh 71 34 1965 1965 CD cord-298503-l60cdllh 71 35 ; ; : cord-298503-l60cdllh 71 36 Rambourg Rambourg NNP cord-298503-l60cdllh 71 37 et et NNP cord-298503-l60cdllh 71 38 al al NNP cord-298503-l60cdllh 71 39 . . NNP cord-298503-l60cdllh 71 40 , , , cord-298503-l60cdllh 71 41 1974 1974 CD cord-298503-l60cdllh 71 42 ) ) -RRB- cord-298503-l60cdllh 71 43 . . . cord-298503-l60cdllh 72 1 However however RB cord-298503-l60cdllh 72 2 , , , cord-298503-l60cdllh 72 3 the the DT cord-298503-l60cdllh 72 4 fungal fungal JJ cord-298503-l60cdllh 72 5 compound compound NN cord-298503-l60cdllh 72 6 brefeldin brefeldin NNS cord-298503-l60cdllh 72 7 A A NNP cord-298503-l60cdllh 72 8 ( ( -LRB- cord-298503-l60cdllh 72 9 BFA BFA NNP cord-298503-l60cdllh 72 10 ) ) -RRB- cord-298503-l60cdllh 72 11 helps help VBZ cord-298503-l60cdllh 72 12 to to TO cord-298503-l60cdllh 72 13 discriminate discriminate VB cord-298503-l60cdllh 72 14 between between IN cord-298503-l60cdllh 72 15 IC IC NNP cord-298503-l60cdllh 72 16 and and CC cord-298503-l60cdllh 72 17 Golgi Golgi NNP cord-298503-l60cdllh 72 18 components component NNS cord-298503-l60cdllh 72 19 . . . cord-298503-l60cdllh 73 1 It -PRON- PRP cord-298503-l60cdllh 73 2 releases release VBZ cord-298503-l60cdllh 73 3 COPI COPI NNP cord-298503-l60cdllh 73 4 coats coat NNS cord-298503-l60cdllh 73 5 , , , cord-298503-l60cdllh 73 6 disassembles disassemble VBZ cord-298503-l60cdllh 73 7 the the DT cord-298503-l60cdllh 73 8 Golgi Golgi NNP cord-298503-l60cdllh 73 9 stacks stack NNS cord-298503-l60cdllh 73 10 and and CC cord-298503-l60cdllh 73 11 redistributes redistribute VBZ cord-298503-l60cdllh 73 12 Golgi Golgi NNP cord-298503-l60cdllh 73 13 components component NNS cord-298503-l60cdllh 73 14 to to IN cord-298503-l60cdllh 73 15 the the DT cord-298503-l60cdllh 73 16 ER ER NNP cord-298503-l60cdllh 73 17 , , , cord-298503-l60cdllh 73 18 whereas whereas IN cord-298503-l60cdllh 73 19 cycling cycling NN cord-298503-l60cdllh 73 20 proteins protein NNS cord-298503-l60cdllh 73 21 ( ( -LRB- cord-298503-l60cdllh 73 22 such such JJ cord-298503-l60cdllh 73 23 as as IN cord-298503-l60cdllh 73 24 p58 p58 NNP cord-298503-l60cdllh 73 25 / / SYM cord-298503-l60cdllh 73 26 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 73 27 / / SYM cord-298503-l60cdllh 73 28 LMAN1 LMAN1 NNP cord-298503-l60cdllh 73 29 and and CC cord-298503-l60cdllh 73 30 the the DT cord-298503-l60cdllh 73 31 KDELreceptor kdelreceptor NN cord-298503-l60cdllh 73 32 ) ) -RRB- cord-298503-l60cdllh 73 33 are be VBP cord-298503-l60cdllh 73 34 arrested arrest VBN cord-298503-l60cdllh 73 35 in in IN cord-298503-l60cdllh 73 36 the the DT cord-298503-l60cdllh 73 37 drug drug NN cord-298503-l60cdllh 73 38 - - HYPH cord-298503-l60cdllh 73 39 resistant resistant JJ cord-298503-l60cdllh 73 40 IC IC NNP cord-298503-l60cdllh 73 41 elements element NNS cord-298503-l60cdllh 73 42 ( ( -LRB- cord-298503-l60cdllh 73 43 Lippincott Lippincott NNP cord-298503-l60cdllh 73 44 - - HYPH cord-298503-l60cdllh 73 45 Schwartz Schwartz NNP cord-298503-l60cdllh 73 46 et et NNP cord-298503-l60cdllh 73 47 al al NNP cord-298503-l60cdllh 73 48 . . NNP cord-298503-l60cdllh 73 49 , , , cord-298503-l60cdllh 73 50 1990 1990 CD cord-298503-l60cdllh 73 51 ; ; : cord-298503-l60cdllh 73 52 Saraste Saraste NNP cord-298503-l60cdllh 73 53 and and CC cord-298503-l60cdllh 73 54 Svensson Svensson NNP cord-298503-l60cdllh 73 55 , , , cord-298503-l60cdllh 73 56 1991 1991 CD cord-298503-l60cdllh 73 57 ; ; : cord-298503-l60cdllh 73 58 Tang Tang NNP cord-298503-l60cdllh 73 59 et et NNP cord-298503-l60cdllh 73 60 al al NNP cord-298503-l60cdllh 73 61 . . NNP cord-298503-l60cdllh 73 62 , , , cord-298503-l60cdllh 73 63 1995b 1995b CD cord-298503-l60cdllh 73 64 ; ; : cord-298503-l60cdllh 73 65 Füllekrug Füllekrug NNP cord-298503-l60cdllh 73 66 et et FW cord-298503-l60cdllh 73 67 al al NNP cord-298503-l60cdllh 73 68 . . NNP cord-298503-l60cdllh 73 69 , , , cord-298503-l60cdllh 73 70 1997 1997 CD cord-298503-l60cdllh 74 1 ; ; : cord-298503-l60cdllh 74 2 Ward Ward NNP cord-298503-l60cdllh 74 3 et et NNP cord-298503-l60cdllh 74 4 al al NNP cord-298503-l60cdllh 74 5 . . NNP cord-298503-l60cdllh 74 6 , , , cord-298503-l60cdllh 74 7 2001 2001 CD cord-298503-l60cdllh 74 8 ; ; : cord-298503-l60cdllh 74 9 Marie Marie NNP cord-298503-l60cdllh 74 10 et et NNP cord-298503-l60cdllh 74 11 al al NNP cord-298503-l60cdllh 74 12 . . NNP cord-298503-l60cdllh 74 13 , , , cord-298503-l60cdllh 74 14 2009 2009 CD cord-298503-l60cdllh 74 15 ) ) -RRB- cord-298503-l60cdllh 74 16 . . . cord-298503-l60cdllh 75 1 The the DT cord-298503-l60cdllh 75 2 BFA BFA NNP cord-298503-l60cdllh 75 3 resistance resistance NN cord-298503-l60cdllh 75 4 of of IN cord-298503-l60cdllh 75 5 the the DT cord-298503-l60cdllh 75 6 IC IC NNP cord-298503-l60cdllh 75 7 has have VBZ cord-298503-l60cdllh 75 8 been be VBN cord-298503-l60cdllh 75 9 utilized utilize VBN cord-298503-l60cdllh 75 10 for for IN cord-298503-l60cdllh 75 11 its -PRON- PRP$ cord-298503-l60cdllh 75 12 proteomics proteomic NNS cord-298503-l60cdllh 75 13 analysis analysis NN cord-298503-l60cdllh 75 14 ( ( -LRB- cord-298503-l60cdllh 75 15 Breuza Breuza NNP cord-298503-l60cdllh 75 16 et et NNP cord-298503-l60cdllh 75 17 al al NNP cord-298503-l60cdllh 75 18 . . NNP cord-298503-l60cdllh 75 19 , , , cord-298503-l60cdllh 75 20 2004 2004 CD cord-298503-l60cdllh 75 21 ) ) -RRB- cord-298503-l60cdllh 75 22 , , , cord-298503-l60cdllh 75 23 and and CC cord-298503-l60cdllh 75 24 indicates indicate VBZ cord-298503-l60cdllh 75 25 its -PRON- PRP$ cord-298503-l60cdllh 75 26 stability stability NN cord-298503-l60cdllh 75 27 . . . cord-298503-l60cdllh 76 1 Like like IN cord-298503-l60cdllh 76 2 p58 p58 NNP cord-298503-l60cdllh 76 3 / / SYM cord-298503-l60cdllh 76 4 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 76 5 , , , cord-298503-l60cdllh 76 6 the the DT cord-298503-l60cdllh 76 7 p24 p24 NN cord-298503-l60cdllh 76 8 family family NN cord-298503-l60cdllh 76 9 proteins protein NNS cord-298503-l60cdllh 76 10 contain contain VBP cord-298503-l60cdllh 76 11 motifs motif NNS cord-298503-l60cdllh 76 12 for for IN cord-298503-l60cdllh 76 13 COPII COPII NNP cord-298503-l60cdllh 76 14 and and CC cord-298503-l60cdllh 76 15 COPI COPI NNP cord-298503-l60cdllh 76 16 binding bind VBG cord-298503-l60cdllh 76 17 , , , cord-298503-l60cdllh 76 18 resulting result VBG cord-298503-l60cdllh 76 19 in in IN cord-298503-l60cdllh 76 20 their -PRON- PRP$ cord-298503-l60cdllh 76 21 cycling cycling NN cord-298503-l60cdllh 76 22 between between IN cord-298503-l60cdllh 76 23 the the DT cord-298503-l60cdllh 76 24 ER ER NNP cord-298503-l60cdllh 76 25 , , , cord-298503-l60cdllh 76 26 IC IC NNP cord-298503-l60cdllh 76 27 , , , cord-298503-l60cdllh 76 28 and and CC cord-298503-l60cdllh 76 29 cis cis NNP cord-298503-l60cdllh 76 30 - - HYPH cord-298503-l60cdllh 76 31 Golgi Golgi NNP cord-298503-l60cdllh 76 32 ( ( -LRB- cord-298503-l60cdllh 76 33 Rojo Rojo NNP cord-298503-l60cdllh 76 34 et et FW cord-298503-l60cdllh 76 35 al al NNP cord-298503-l60cdllh 76 36 . . NNP cord-298503-l60cdllh 76 37 , , , cord-298503-l60cdllh 76 38 1997 1997 CD cord-298503-l60cdllh 76 39 ; ; : cord-298503-l60cdllh 76 40 Dominguez Dominguez NNP cord-298503-l60cdllh 76 41 et et NNP cord-298503-l60cdllh 76 42 al al NNP cord-298503-l60cdllh 76 43 . . . cord-298503-l60cdllh 77 1 , , , cord-298503-l60cdllh 77 2 1998 1998 CD cord-298503-l60cdllh 77 3 ; ; : cord-298503-l60cdllh 77 4 Blum Blum NNP cord-298503-l60cdllh 77 5 et et NNP cord-298503-l60cdllh 77 6 al al NNP cord-298503-l60cdllh 77 7 . . . cord-298503-l60cdllh 78 1 , , , cord-298503-l60cdllh 78 2 1999 1999 CD cord-298503-l60cdllh 78 3 ; ; : cord-298503-l60cdllh 78 4 Gommel Gommel NNP cord-298503-l60cdllh 78 5 et et FW cord-298503-l60cdllh 78 6 al al NNP cord-298503-l60cdllh 78 7 . . . cord-298503-l60cdllh 79 1 , , , cord-298503-l60cdllh 79 2 1999 1999 CD cord-298503-l60cdllh 79 3 ; ; : cord-298503-l60cdllh 79 4 Strating Strating NNP cord-298503-l60cdllh 79 5 and and CC cord-298503-l60cdllh 79 6 Martens Martens NNPS cord-298503-l60cdllh 79 7 , , , cord-298503-l60cdllh 79 8 2009 2009 CD cord-298503-l60cdllh 79 9 ) ) -RRB- cord-298503-l60cdllh 79 10 . . . cord-298503-l60cdllh 80 1 As as IN cord-298503-l60cdllh 80 2 abundant abundant JJ cord-298503-l60cdllh 80 3 type-1 type-1 NN cord-298503-l60cdllh 80 4 transmembrane transmembrane NN cord-298503-l60cdllh 80 5 proteins protein NNS cord-298503-l60cdllh 80 6 they -PRON- PRP cord-298503-l60cdllh 80 7 participate participate VBP cord-298503-l60cdllh 80 8 in in IN cord-298503-l60cdllh 80 9 the the DT cord-298503-l60cdllh 80 10 biogenesis biogenesis NN cord-298503-l60cdllh 80 11 of of IN cord-298503-l60cdllh 80 12 COPI COPI NNP cord-298503-l60cdllh 80 13 vesicles vesicle NNS cord-298503-l60cdllh 80 14 ( ( -LRB- cord-298503-l60cdllh 80 15 Stamnes Stamnes NNP cord-298503-l60cdllh 80 16 et et NNP cord-298503-l60cdllh 80 17 al al NNP cord-298503-l60cdllh 80 18 . . NNP cord-298503-l60cdllh 80 19 , , , cord-298503-l60cdllh 80 20 1995 1995 CD cord-298503-l60cdllh 80 21 ; ; : cord-298503-l60cdllh 80 22 Majoul Majoul NNP cord-298503-l60cdllh 80 23 et et FW cord-298503-l60cdllh 80 24 al al NNP cord-298503-l60cdllh 80 25 . . NNP cord-298503-l60cdllh 80 26 , , , cord-298503-l60cdllh 80 27 2001 2001 CD cord-298503-l60cdllh 80 28 ; ; : cord-298503-l60cdllh 80 29 Beck Beck NNP cord-298503-l60cdllh 80 30 et et NNP cord-298503-l60cdllh 80 31 al al NNP cord-298503-l60cdllh 80 32 . . NNP cord-298503-l60cdllh 80 33 , , , cord-298503-l60cdllh 80 34 2009 2009 CD cord-298503-l60cdllh 80 35 ) ) -RRB- cord-298503-l60cdllh 80 36 , , , cord-298503-l60cdllh 80 37 but but CC cord-298503-l60cdllh 80 38 have have VBP cord-298503-l60cdllh 80 39 also also RB cord-298503-l60cdllh 80 40 been be VBN cord-298503-l60cdllh 80 41 implicated implicate VBN cord-298503-l60cdllh 80 42 in in IN cord-298503-l60cdllh 80 43 tubulation tubulation NN cord-298503-l60cdllh 80 44 and and CC cord-298503-l60cdllh 80 45 the the DT cord-298503-l60cdllh 80 46 formation formation NN cord-298503-l60cdllh 80 47 of of IN cord-298503-l60cdllh 80 48 membrane membrane NN cord-298503-l60cdllh 80 49 domains domain NNS cord-298503-l60cdllh 80 50 ( ( -LRB- cord-298503-l60cdllh 80 51 Lavoie Lavoie NNP cord-298503-l60cdllh 80 52 et et NNP cord-298503-l60cdllh 80 53 al al NNP cord-298503-l60cdllh 80 54 . . NNP cord-298503-l60cdllh 80 55 , , , cord-298503-l60cdllh 80 56 1999 1999 CD cord-298503-l60cdllh 80 57 ; ; : cord-298503-l60cdllh 80 58 Emery Emery NNP cord-298503-l60cdllh 80 59 et et NNP cord-298503-l60cdllh 80 60 al al NNP cord-298503-l60cdllh 80 61 . . NNP cord-298503-l60cdllh 80 62 , , , cord-298503-l60cdllh 80 63 2003 2003 CD cord-298503-l60cdllh 80 64 ) ) -RRB- cord-298503-l60cdllh 80 65 . . . cord-298503-l60cdllh 81 1 Studies study NNS cord-298503-l60cdllh 81 2 in in IN cord-298503-l60cdllh 81 3 yeast yeast NN cord-298503-l60cdllh 81 4 first first RB cord-298503-l60cdllh 81 5 suggested suggest VBD cord-298503-l60cdllh 81 6 their -PRON- PRP$ cord-298503-l60cdllh 81 7 function function NN cord-298503-l60cdllh 81 8 as as IN cord-298503-l60cdllh 81 9 receptors receptor NNS cord-298503-l60cdllh 81 10 for for IN cord-298503-l60cdllh 81 11 the the DT cord-298503-l60cdllh 81 12 exit exit NN cord-298503-l60cdllh 81 13 of of IN cord-298503-l60cdllh 81 14 glycosylphosphatidylinositol glycosylphosphatidylinositol NNP cord-298503-l60cdllh 81 15 ( ( -LRB- cord-298503-l60cdllh 81 16 GPI)-anchored gpi)-anchored JJ cord-298503-l60cdllh 81 17 proteins protein NNS cord-298503-l60cdllh 81 18 from from IN cord-298503-l60cdllh 81 19 the the DT cord-298503-l60cdllh 81 20 ER er NN cord-298503-l60cdllh 82 1 ( ( -LRB- cord-298503-l60cdllh 82 2 Schimmöller Schimmöller NNP cord-298503-l60cdllh 82 3 et et NNP cord-298503-l60cdllh 82 4 al al NNP cord-298503-l60cdllh 82 5 . . NNP cord-298503-l60cdllh 82 6 , , , cord-298503-l60cdllh 82 7 1995 1995 CD cord-298503-l60cdllh 82 8 ) ) -RRB- cord-298503-l60cdllh 82 9 . . . cord-298503-l60cdllh 83 1 The the DT cord-298503-l60cdllh 83 2 COPI COPI NNP cord-298503-l60cdllh 83 3 coats coat NNS cord-298503-l60cdllh 83 4 are be VBP cord-298503-l60cdllh 83 5 mainly mainly RB cord-298503-l60cdllh 83 6 recruited recruit VBN cord-298503-l60cdllh 83 7 to to IN cord-298503-l60cdllh 83 8 the the DT cord-298503-l60cdllh 83 9 cytoplasmic cytoplasmic JJ cord-298503-l60cdllh 83 10 surface surface NN cord-298503-l60cdllh 83 11 of of IN cord-298503-l60cdllh 83 12 IC IC NNP cord-298503-l60cdllh 83 13 and and CC cord-298503-l60cdllh 83 14 cis cis NNP cord-298503-l60cdllh 83 15 - - HYPH cord-298503-l60cdllh 83 16 Golgi Golgi NNP cord-298503-l60cdllh 83 17 membranes membrane NNS cord-298503-l60cdllh 83 18 , , , cord-298503-l60cdllh 83 19 but but CC cord-298503-l60cdllh 83 20 also also RB cord-298503-l60cdllh 83 21 associate associate VB cord-298503-l60cdllh 83 22 with with IN cord-298503-l60cdllh 83 23 the the DT cord-298503-l60cdllh 83 24 lateral lateral JJ cord-298503-l60cdllh 83 25 rims rim NNS cord-298503-l60cdllh 83 26 of of IN cord-298503-l60cdllh 83 27 the the DT cord-298503-l60cdllh 83 28 Golgi Golgi NNP cord-298503-l60cdllh 83 29 stacks stack NNS cord-298503-l60cdllh 84 1 ( ( -LRB- cord-298503-l60cdllh 84 2 Duden Duden NNP cord-298503-l60cdllh 84 3 et et FW cord-298503-l60cdllh 84 4 al al NNP cord-298503-l60cdllh 84 5 . . . cord-298503-l60cdllh 85 1 , , , cord-298503-l60cdllh 85 2 1991 1991 CD cord-298503-l60cdllh 85 3 ; ; : cord-298503-l60cdllh 85 4 Oprins Oprins NNP cord-298503-l60cdllh 85 5 et et NNP cord-298503-l60cdllh 85 6 al al NNP cord-298503-l60cdllh 85 7 . . . cord-298503-l60cdllh 86 1 , , , cord-298503-l60cdllh 86 2 1993 1993 CD cord-298503-l60cdllh 86 3 ; ; : cord-298503-l60cdllh 86 4 Griffiths Griffiths NNP cord-298503-l60cdllh 86 5 et et NNP cord-298503-l60cdllh 86 6 al al NNP cord-298503-l60cdllh 86 7 . . NNP cord-298503-l60cdllh 86 8 , , , cord-298503-l60cdllh 86 9 1995 1995 CD cord-298503-l60cdllh 86 10 ; ; : cord-298503-l60cdllh 86 11 Orci Orci NNP cord-298503-l60cdllh 86 12 et et NNP cord-298503-l60cdllh 86 13 al al NNP cord-298503-l60cdllh 86 14 . . NNP cord-298503-l60cdllh 86 15 , , , cord-298503-l60cdllh 86 16 1997 1997 CD cord-298503-l60cdllh 86 17 ; ; : cord-298503-l60cdllh 86 18 Klumperman Klumperman NNP cord-298503-l60cdllh 86 19 et et FW cord-298503-l60cdllh 86 20 al al NNP cord-298503-l60cdllh 86 21 . . NNP cord-298503-l60cdllh 86 22 , , , cord-298503-l60cdllh 86 23 1998 1998 CD cord-298503-l60cdllh 86 24 ) ) -RRB- cord-298503-l60cdllh 86 25 . . . cord-298503-l60cdllh 87 1 COPI COPI NNP cord-298503-l60cdllh 87 2 vesicle vesicle NN cord-298503-l60cdllh 87 3 budding bud VBG cord-298503-l60cdllh 87 4 depends depend VBZ cord-298503-l60cdllh 87 5 on on IN cord-298503-l60cdllh 87 6 the the DT cord-298503-l60cdllh 87 7 activation activation NN cord-298503-l60cdllh 87 8 of of IN cord-298503-l60cdllh 87 9 small small JJ cord-298503-l60cdllh 87 10 GTPases gtpase NNS cord-298503-l60cdllh 87 11 of of IN cord-298503-l60cdllh 87 12 the the DT cord-298503-l60cdllh 87 13 ADP ADP NNP cord-298503-l60cdllh 87 14 - - HYPH cord-298503-l60cdllh 87 15 ribosylation ribosylation NN cord-298503-l60cdllh 87 16 factor factor NN cord-298503-l60cdllh 87 17 ( ( -LRB- cord-298503-l60cdllh 87 18 Arf Arf NNP cord-298503-l60cdllh 87 19 ) ) -RRB- cord-298503-l60cdllh 87 20 family family NN cord-298503-l60cdllh 87 21 ( ( -LRB- cord-298503-l60cdllh 87 22 Popoff Popoff NNP cord-298503-l60cdllh 87 23 et et NNP cord-298503-l60cdllh 87 24 al al NNP cord-298503-l60cdllh 87 25 . . NNP cord-298503-l60cdllh 87 26 , , , cord-298503-l60cdllh 87 27 2011 2011 CD cord-298503-l60cdllh 87 28 ) ) -RRB- cord-298503-l60cdllh 87 29 . . . cord-298503-l60cdllh 88 1 The the DT cord-298503-l60cdllh 88 2 guanine guanine NN cord-298503-l60cdllh 88 3 nucleotide nucleotide JJ cord-298503-l60cdllh 88 4 exchange exchange NN cord-298503-l60cdllh 88 5 factor factor NN cord-298503-l60cdllh 88 6 ( ( -LRB- cord-298503-l60cdllh 88 7 GEF GEF NNP cord-298503-l60cdllh 88 8 ) ) -RRB- cord-298503-l60cdllh 88 9 of of IN cord-298503-l60cdllh 88 10 these these DT cord-298503-l60cdllh 88 11 Arfs Arfs NNP cord-298503-l60cdllh 88 12 , , , cord-298503-l60cdllh 88 13 GBF1 GBF1 NNP cord-298503-l60cdllh 88 14 , , , cord-298503-l60cdllh 88 15 is be VBZ cord-298503-l60cdllh 88 16 the the DT cord-298503-l60cdllh 88 17 master master NN cord-298503-l60cdllh 88 18 regulator regulator NN cord-298503-l60cdllh 88 19 of of IN cord-298503-l60cdllh 88 20 COPI COPI NNP cord-298503-l60cdllh 88 21 recruitment recruitment NN cord-298503-l60cdllh 88 22 and and CC cord-298503-l60cdllh 88 23 the the DT cord-298503-l60cdllh 88 24 target target NN cord-298503-l60cdllh 88 25 of of IN cord-298503-l60cdllh 88 26 BFA BFA NNP cord-298503-l60cdllh 88 27 ( ( -LRB- cord-298503-l60cdllh 88 28 Niu Niu NNP cord-298503-l60cdllh 88 29 et et NNP cord-298503-l60cdllh 88 30 al al NNP cord-298503-l60cdllh 88 31 . . NNP cord-298503-l60cdllh 88 32 , , , cord-298503-l60cdllh 88 33 2005 2005 CD cord-298503-l60cdllh 88 34 ) ) -RRB- cord-298503-l60cdllh 88 35 . . . cord-298503-l60cdllh 89 1 It -PRON- PRP cord-298503-l60cdllh 89 2 localizes localize VBZ cord-298503-l60cdllh 89 3 to to IN cord-298503-l60cdllh 89 4 the the DT cord-298503-l60cdllh 89 5 IC IC NNP cord-298503-l60cdllh 89 6 and and CC cord-298503-l60cdllh 89 7 cis cis NNP cord-298503-l60cdllh 89 8 - - HYPH cord-298503-l60cdllh 89 9 Golgi Golgi NNP cord-298503-l60cdllh 89 10 and and CC cord-298503-l60cdllh 89 11 plays play VBZ cord-298503-l60cdllh 89 12 a a DT cord-298503-l60cdllh 89 13 key key JJ cord-298503-l60cdllh 89 14 role role NN cord-298503-l60cdllh 89 15 in in IN cord-298503-l60cdllh 89 16 ER ER NNP cord-298503-l60cdllh 89 17 - - HYPH cord-298503-l60cdllh 89 18 to to IN cord-298503-l60cdllh 89 19 - - HYPH cord-298503-l60cdllh 89 20 Golgi golgi NN cord-298503-l60cdllh 89 21 trafficking trafficking NN cord-298503-l60cdllh 89 22 ( ( -LRB- cord-298503-l60cdllh 89 23 Kawamoto Kawamoto NNP cord-298503-l60cdllh 89 24 et et NNP cord-298503-l60cdllh 89 25 al al NNP cord-298503-l60cdllh 89 26 . . NNP cord-298503-l60cdllh 89 27 , , , cord-298503-l60cdllh 89 28 2002 2002 CD cord-298503-l60cdllh 89 29 ; ; : cord-298503-l60cdllh 89 30 Garcia Garcia NNP cord-298503-l60cdllh 89 31 - - HYPH cord-298503-l60cdllh 89 32 Mata Mata NNP cord-298503-l60cdllh 89 33 et et NNP cord-298503-l60cdllh 89 34 al al NNP cord-298503-l60cdllh 89 35 . . . cord-298503-l60cdllh 90 1 , , , cord-298503-l60cdllh 90 2 2003 2003 CD cord-298503-l60cdllh 90 3 ; ; : cord-298503-l60cdllh 90 4 Zhao Zhao NNP cord-298503-l60cdllh 90 5 et et NNP cord-298503-l60cdllh 90 6 al al NNP cord-298503-l60cdllh 90 7 . . NNP cord-298503-l60cdllh 90 8 , , , cord-298503-l60cdllh 90 9 2006 2006 CD cord-298503-l60cdllh 90 10 ; ; . cord-298503-l60cdllh 91 1 Szul Szul NNP cord-298503-l60cdllh 91 2 et et NNP cord-298503-l60cdllh 91 3 al al NNP cord-298503-l60cdllh 91 4 . . NNP cord-298503-l60cdllh 91 5 , , , cord-298503-l60cdllh 91 6 2007 2007 CD cord-298503-l60cdllh 91 7 ) ) -RRB- cord-298503-l60cdllh 91 8 . . . cord-298503-l60cdllh 92 1 GBF1 GBF1 NNP cord-298503-l60cdllh 92 2 knock knock VB cord-298503-l60cdllh 92 3 down down RP cord-298503-l60cdllh 92 4 or or CC cord-298503-l60cdllh 92 5 specific specific JJ cord-298503-l60cdllh 92 6 inhibition inhibition NN cord-298503-l60cdllh 92 7 by by IN cord-298503-l60cdllh 92 8 Golgicide Golgicide NNP cord-298503-l60cdllh 92 9 A A NNP cord-298503-l60cdllh 92 10 releases release VBZ cord-298503-l60cdllh 92 11 COPI COPI NNP cord-298503-l60cdllh 92 12 coats coat NNS cord-298503-l60cdllh 92 13 and and CC cord-298503-l60cdllh 92 14 arrests arrest VBZ cord-298503-l60cdllh 92 15 the the DT cord-298503-l60cdllh 92 16 VSV VSV NNP cord-298503-l60cdllh 92 17 G G NNP cord-298503-l60cdllh 92 18 - - HYPH cord-298503-l60cdllh 92 19 protein protein NN cord-298503-l60cdllh 92 20 in in IN cord-298503-l60cdllh 92 21 the the DT cord-298503-l60cdllh 92 22 IC IC NNP cord-298503-l60cdllh 92 23 , , , cord-298503-l60cdllh 92 24 indicating indicate VBG cord-298503-l60cdllh 92 25 its -PRON- PRP$ cord-298503-l60cdllh 92 26 involvement involvement NN cord-298503-l60cdllh 92 27 in in IN cord-298503-l60cdllh 92 28 anterograde anterograde JJ cord-298503-l60cdllh 92 29 IC IC NNP cord-298503-l60cdllh 92 30 - - HYPH cord-298503-l60cdllh 92 31 to to IN cord-298503-l60cdllh 92 32 - - HYPH cord-298503-l60cdllh 92 33 Golgi golgi NN cord-298503-l60cdllh 92 34 transport transport NN cord-298503-l60cdllh 92 35 ( ( -LRB- cord-298503-l60cdllh 92 36 Manolea Manolea NNP cord-298503-l60cdllh 92 37 et et NNP cord-298503-l60cdllh 92 38 al al NNP cord-298503-l60cdllh 92 39 . . NNP cord-298503-l60cdllh 92 40 , , , cord-298503-l60cdllh 92 41 2008 2008 CD cord-298503-l60cdllh 92 42 ; ; . cord-298503-l60cdllh 93 1 Sáenz Sáenz NNP cord-298503-l60cdllh 93 2 et et NNP cord-298503-l60cdllh 93 3 al al NNP cord-298503-l60cdllh 93 4 . . NNP cord-298503-l60cdllh 93 5 , , , cord-298503-l60cdllh 93 6 2009 2009 CD cord-298503-l60cdllh 93 7 ) ) -RRB- cord-298503-l60cdllh 93 8 . . . cord-298503-l60cdllh 94 1 However however RB cord-298503-l60cdllh 94 2 , , , cord-298503-l60cdllh 94 3 the the DT cord-298503-l60cdllh 94 4 prevailing prevail VBG cord-298503-l60cdllh 94 5 view view NN cord-298503-l60cdllh 94 6 is be VBZ cord-298503-l60cdllh 94 7 that that IN cord-298503-l60cdllh 94 8 the the DT cord-298503-l60cdllh 94 9 main main JJ cord-298503-l60cdllh 94 10 function function NN cord-298503-l60cdllh 94 11 of of IN cord-298503-l60cdllh 94 12 COPI COPI NNP cord-298503-l60cdllh 94 13 vesicles vesicle NNS cord-298503-l60cdllh 94 14 is be VBZ cord-298503-l60cdllh 94 15 to to TO cord-298503-l60cdllh 94 16 recycle recycle VB cord-298503-l60cdllh 94 17 membrane membrane NN cord-298503-l60cdllh 94 18 and and CC cord-298503-l60cdllh 94 19 selected select VBN cord-298503-l60cdllh 94 20 proteins protein NNS cord-298503-l60cdllh 94 21 to to IN cord-298503-l60cdllh 94 22 the the DT cord-298503-l60cdllh 94 23 ER ER NNP cord-298503-l60cdllh 94 24 . . . cord-298503-l60cdllh 95 1 In in IN cord-298503-l60cdllh 95 2 pancreatic pancreatic JJ cord-298503-l60cdllh 95 3 exocrine exocrine NN cord-298503-l60cdllh 95 4 cells cell NNS cord-298503-l60cdllh 95 5 approximately approximately RB cord-298503-l60cdllh 95 6 70 70 CD cord-298503-l60cdllh 95 7 % % NN cord-298503-l60cdllh 95 8 of of IN cord-298503-l60cdllh 95 9 the the DT cord-298503-l60cdllh 95 10 coats coat NNS cord-298503-l60cdllh 95 11 associate associate JJ cord-298503-l60cdllh 95 12 with with IN cord-298503-l60cdllh 95 13 the the DT cord-298503-l60cdllh 95 14 VTCs vtc NNS cord-298503-l60cdllh 95 15 , , , cord-298503-l60cdllh 95 16 suggesting suggest VBG cord-298503-l60cdllh 95 17 that that IN cord-298503-l60cdllh 95 18 the the DT cord-298503-l60cdllh 95 19 IC IC NNP cord-298503-l60cdllh 95 20 represents represent VBZ cord-298503-l60cdllh 95 21 the the DT cord-298503-l60cdllh 95 22 main main JJ cord-298503-l60cdllh 95 23 point point NN cord-298503-l60cdllh 95 24 for for IN cord-298503-l60cdllh 95 25 recycling recycling NN cord-298503-l60cdllh 95 26 ( ( -LRB- cord-298503-l60cdllh 95 27 Martínez Martínez NNP cord-298503-l60cdllh 95 28 - - HYPH cord-298503-l60cdllh 95 29 Menárguez Menárguez NNP cord-298503-l60cdllh 95 30 et et NNP cord-298503-l60cdllh 95 31 al al NNP cord-298503-l60cdllh 95 32 . . NNP cord-298503-l60cdllh 95 33 , , , cord-298503-l60cdllh 95 34 1999 1999 CD cord-298503-l60cdllh 95 35 ) ) -RRB- cord-298503-l60cdllh 95 36 . . . cord-298503-l60cdllh 96 1 The the DT cord-298503-l60cdllh 96 2 roles role NNS cord-298503-l60cdllh 96 3 of of IN cord-298503-l60cdllh 96 4 two two CD cord-298503-l60cdllh 96 5 GTPases gtpase NNS cord-298503-l60cdllh 96 6 of of IN cord-298503-l60cdllh 96 7 the the DT cord-298503-l60cdllh 96 8 large large JJ cord-298503-l60cdllh 96 9 Rab Rab NNP cord-298503-l60cdllh 96 10 family family NN cord-298503-l60cdllh 96 11 , , , cord-298503-l60cdllh 96 12 Rab1 Rab1 NNP cord-298503-l60cdllh 96 13 and and CC cord-298503-l60cdllh 96 14 Rab2 Rab2 NNP cord-298503-l60cdllh 96 15 , , , cord-298503-l60cdllh 96 16 in in IN cord-298503-l60cdllh 96 17 ER ER NNP cord-298503-l60cdllh 96 18 - - HYPH cord-298503-l60cdllh 96 19 Golgi Golgi NNP cord-298503-l60cdllh 96 20 trafficking trafficking NN cord-298503-l60cdllh 96 21 are be VBP cord-298503-l60cdllh 96 22 relatively relatively RB cord-298503-l60cdllh 96 23 well well RB cord-298503-l60cdllh 96 24 understood understand VBN cord-298503-l60cdllh 96 25 ( ( -LRB- cord-298503-l60cdllh 96 26 Plutner Plutner NNP cord-298503-l60cdllh 96 27 et et NNP cord-298503-l60cdllh 96 28 al al NNP cord-298503-l60cdllh 96 29 . . NNP cord-298503-l60cdllh 96 30 , , , cord-298503-l60cdllh 96 31 1991 1991 CD cord-298503-l60cdllh 96 32 ; ; : cord-298503-l60cdllh 96 33 Tisdale Tisdale NNP cord-298503-l60cdllh 96 34 et et NNP cord-298503-l60cdllh 96 35 al al NNP cord-298503-l60cdllh 96 36 . . NNP cord-298503-l60cdllh 96 37 , , , cord-298503-l60cdllh 96 38 1992 1992 CD cord-298503-l60cdllh 96 39 ) ) -RRB- cord-298503-l60cdllh 96 40 . . . cord-298503-l60cdllh 97 1 Both both DT cord-298503-l60cdllh 97 2 interact interact VBP cord-298503-l60cdllh 97 3 with with IN cord-298503-l60cdllh 97 4 multiple multiple JJ cord-298503-l60cdllh 97 5 effectors effector NNS cord-298503-l60cdllh 97 6 suggesting suggest VBG cord-298503-l60cdllh 97 7 that that IN cord-298503-l60cdllh 97 8 they -PRON- PRP cord-298503-l60cdllh 97 9 coordinate coordinate VBP cord-298503-l60cdllh 97 10 successive successive JJ cord-298503-l60cdllh 97 11 transport transport NN cord-298503-l60cdllh 97 12 steps step NNS cord-298503-l60cdllh 97 13 ( ( -LRB- cord-298503-l60cdllh 97 14 Barnekow Barnekow NNP cord-298503-l60cdllh 97 15 et et NNP cord-298503-l60cdllh 97 16 al al NNP cord-298503-l60cdllh 97 17 . . NNP cord-298503-l60cdllh 97 18 , , , cord-298503-l60cdllh 97 19 2009 2009 CD cord-298503-l60cdllh 97 20 ) ) -RRB- cord-298503-l60cdllh 97 21 . . . cord-298503-l60cdllh 98 1 The the DT cord-298503-l60cdllh 98 2 association association NN cord-298503-l60cdllh 98 3 of of IN cord-298503-l60cdllh 98 4 Rab1 Rab1 NNP cord-298503-l60cdllh 98 5 with with IN cord-298503-l60cdllh 98 6 the the DT cord-298503-l60cdllh 98 7 cytoplasmic cytoplasmic JJ cord-298503-l60cdllh 98 8 surface surface NN cord-298503-l60cdllh 98 9 of of IN cord-298503-l60cdllh 98 10 IC IC NNP cord-298503-l60cdllh 98 11 and and CC cord-298503-l60cdllh 98 12 cis cis NNP cord-298503-l60cdllh 98 13 - - HYPH cord-298503-l60cdllh 98 14 Golgi Golgi NNP cord-298503-l60cdllh 98 15 membranes membrane NNS cord-298503-l60cdllh 98 16 , , , cord-298503-l60cdllh 98 17 and and CC cord-298503-l60cdllh 98 18 its -PRON- PRP$ cord-298503-l60cdllh 98 19 absence absence NN cord-298503-l60cdllh 98 20 from from IN cord-298503-l60cdllh 98 21 the the DT cord-298503-l60cdllh 98 22 ER ER NNP cord-298503-l60cdllh 98 23 , , , cord-298503-l60cdllh 98 24 has have VBZ cord-298503-l60cdllh 98 25 been be VBN cord-298503-l60cdllh 98 26 demonstrated demonstrate VBN cord-298503-l60cdllh 98 27 by by IN cord-298503-l60cdllh 98 28 EM EM NNP cord-298503-l60cdllh 98 29 Saraste Saraste NNP cord-298503-l60cdllh 98 30 et et NNP cord-298503-l60cdllh 98 31 al al NNP cord-298503-l60cdllh 98 32 . . NNP cord-298503-l60cdllh 98 33 , , , cord-298503-l60cdllh 98 34 1995 1995 CD cord-298503-l60cdllh 98 35 ; ; : cord-298503-l60cdllh 98 36 Satoh Satoh NNP cord-298503-l60cdllh 98 37 et et FW cord-298503-l60cdllh 98 38 al al NNP cord-298503-l60cdllh 98 39 . . NNP cord-298503-l60cdllh 98 40 , , , cord-298503-l60cdllh 98 41 2003 2003 CD cord-298503-l60cdllh 98 42 ; ; : cord-298503-l60cdllh 98 43 Marie Marie NNP cord-298503-l60cdllh 98 44 et et NNP cord-298503-l60cdllh 98 45 al al NNP cord-298503-l60cdllh 98 46 . . . cord-298503-l60cdllh 99 1 , , , cord-298503-l60cdllh 99 2 2012 2012 CD cord-298503-l60cdllh 99 3 ; ; : cord-298503-l60cdllh 99 4 Figure figure NN cord-298503-l60cdllh 99 5 2 2 CD cord-298503-l60cdllh 99 6 ) ) -RRB- cord-298503-l60cdllh 99 7 . . . cord-298503-l60cdllh 100 1 The the DT cord-298503-l60cdllh 100 2 two two CD cord-298503-l60cdllh 100 3 Rab1 rab1 NN cord-298503-l60cdllh 100 4 isoforms isoform NNS cord-298503-l60cdllh 100 5 , , , cord-298503-l60cdllh 100 6 Rab1A Rab1A NNS cord-298503-l60cdllh 100 7 and and CC cord-298503-l60cdllh 100 8 RAB1B rab1b NN cord-298503-l60cdllh 100 9 ( ( -LRB- cord-298503-l60cdllh 100 10 93 93 CD cord-298503-l60cdllh 100 11 % % NN cord-298503-l60cdllh 100 12 homology homology NN cord-298503-l60cdllh 100 13 ) ) -RRB- cord-298503-l60cdllh 100 14 , , , cord-298503-l60cdllh 100 15 are be VBP cord-298503-l60cdllh 100 16 recruited recruit VBN cord-298503-l60cdllh 100 17 to to IN cord-298503-l60cdllh 100 18 IC IC NNP cord-298503-l60cdllh 100 19 membranes membrane NNS cord-298503-l60cdllh 100 20 at at IN cord-298503-l60cdllh 100 21 ERES ERES NNP cord-298503-l60cdllh 100 22 , , , cord-298503-l60cdllh 100 23 show show VBP cord-298503-l60cdllh 100 24 similar similar JJ cord-298503-l60cdllh 100 25 localizations localization NNS cord-298503-l60cdllh 100 26 by by IN cord-298503-l60cdllh 100 27 LM LM NNP cord-298503-l60cdllh 100 28 ( ( -LRB- cord-298503-l60cdllh 100 29 Mochizuki Mochizuki NNP cord-298503-l60cdllh 100 30 et et NNP cord-298503-l60cdllh 100 31 al al NNP cord-298503-l60cdllh 100 32 . . NNP cord-298503-l60cdllh 100 33 , , , cord-298503-l60cdllh 100 34 2013 2013 CD cord-298503-l60cdllh 100 35 ; ; : cord-298503-l60cdllh 101 1 Figure figure NN cord-298503-l60cdllh 101 2 3 3 CD cord-298503-l60cdllh 101 3 ( ( -LRB- cord-298503-l60cdllh 101 4 a a NN cord-298503-l60cdllh 101 5 ) ) -RRB- cord-298503-l60cdllh 101 6 ) ) -RRB- cord-298503-l60cdllh 101 7 , , , cord-298503-l60cdllh 101 8 but but CC cord-298503-l60cdllh 101 9 seem seem VBP cord-298503-l60cdllh 101 10 to to TO cord-298503-l60cdllh 101 11 play play VB cord-298503-l60cdllh 101 12 distinct distinct JJ cord-298503-l60cdllh 101 13 roles role NNS cord-298503-l60cdllh 101 14 in in IN cord-298503-l60cdllh 101 15 tubular tubular JJ cord-298503-l60cdllh 101 16 and and CC cord-298503-l60cdllh 101 17 vesicular vesicular JJ cord-298503-l60cdllh 101 18 ( ( -LRB- cord-298503-l60cdllh 101 19 long long JJ cord-298503-l60cdllh 101 20 and and CC cord-298503-l60cdllh 101 21 short short JJ cord-298503-l60cdllh 101 22 range range NN cord-298503-l60cdllh 101 23 ) ) -RRB- cord-298503-l60cdllh 101 24 trafficking trafficking NN cord-298503-l60cdllh 101 25 within within IN cord-298503-l60cdllh 101 26 the the DT cord-298503-l60cdllh 101 27 IC IC NNP cord-298503-l60cdllh 101 28 . . . cord-298503-l60cdllh 102 1 Accordingly accordingly RB cord-298503-l60cdllh 102 2 , , , cord-298503-l60cdllh 102 3 live live JJ cord-298503-l60cdllh 102 4 cell cell NN cord-298503-l60cdllh 102 5 imaging imaging NN cord-298503-l60cdllh 102 6 and and CC cord-298503-l60cdllh 102 7 cell cell NN cord-298503-l60cdllh 102 8 fractionation fractionation NN cord-298503-l60cdllh 102 9 have have VBP cord-298503-l60cdllh 102 10 shown show VBN cord-298503-l60cdllh 102 11 that that IN cord-298503-l60cdllh 102 12 Rab1A Rab1A NNP cord-298503-l60cdllh 102 13 mainly mainly RB cord-298503-l60cdllh 102 14 associates associate NNS cord-298503-l60cdllh 102 15 with with IN cord-298503-l60cdllh 102 16 IC IC NNP cord-298503-l60cdllh 102 17 tubules tubule NNS cord-298503-l60cdllh 102 18 ( ( -LRB- cord-298503-l60cdllh 102 19 Sannerud Sannerud NNP cord-298503-l60cdllh 102 20 et et NNP cord-298503-l60cdllh 102 21 al al NNP cord-298503-l60cdllh 102 22 . . NNP cord-298503-l60cdllh 102 23 , , , cord-298503-l60cdllh 102 24 2006 2006 CD cord-298503-l60cdllh 102 25 ; ; . cord-298503-l60cdllh 103 1 Marie Marie NNP cord-298503-l60cdllh 103 2 et et NNP cord-298503-l60cdllh 103 3 al al NNP cord-298503-l60cdllh 103 4 . . NNP cord-298503-l60cdllh 103 5 , , , cord-298503-l60cdllh 103 6 2009 2009 CD cord-298503-l60cdllh 103 7 ) ) -RRB- cord-298503-l60cdllh 103 8 , , , cord-298503-l60cdllh 103 9 while while IN cord-298503-l60cdllh 103 10 Rab1B rab1b PRP cord-298503-l60cdllh 103 11 interacts interact VBZ cord-298503-l60cdllh 103 12 with with IN cord-298503-l60cdllh 103 13 GBF1 GBF1 NNP cord-298503-l60cdllh 103 14 and and CC cord-298503-l60cdllh 103 15 evidently evidently RB cord-298503-l60cdllh 103 16 modulates modulate VBZ cord-298503-l60cdllh 103 17 COPI COPI NNP cord-298503-l60cdllh 103 18 recruitment recruitment NN cord-298503-l60cdllh 103 19 to to IN cord-298503-l60cdllh 103 20 globular globular JJ cord-298503-l60cdllh 103 21 IC IC NNP cord-298503-l60cdllh 103 22 domains domain NNS cord-298503-l60cdllh 103 23 Monetta Monetta NNP cord-298503-l60cdllh 103 24 et et NNP cord-298503-l60cdllh 103 25 al al NNP cord-298503-l60cdllh 104 1 . . NNP cord-298503-l60cdllh 104 2 , , , cord-298503-l60cdllh 104 3 2007 2007 CD cord-298503-l60cdllh 104 4 ; ; : cord-298503-l60cdllh 104 5 see see VB cord-298503-l60cdllh 104 6 below below RB cord-298503-l60cdllh 104 7 ) ) -RRB- cord-298503-l60cdllh 104 8 . . . cord-298503-l60cdllh 105 1 Also also RB cord-298503-l60cdllh 105 2 , , , cord-298503-l60cdllh 105 3 Rab1A Rab1A NNP cord-298503-l60cdllh 105 4 is be VBZ cord-298503-l60cdllh 105 5 specifically specifically RB cord-298503-l60cdllh 105 6 Nu Nu NNP cord-298503-l60cdllh 106 1 * * NFP cord-298503-l60cdllh 106 2 * * NFP cord-298503-l60cdllh 106 3 * * NFP cord-298503-l60cdllh 106 4 * * NFP cord-298503-l60cdllh 106 5 Figure figure NN cord-298503-l60cdllh 106 6 1 1 CD cord-298503-l60cdllh 106 7 ( ( -LRB- cord-298503-l60cdllh 106 8 a a DT cord-298503-l60cdllh 106 9 ) ) -RRB- cord-298503-l60cdllh 106 10 Immunofluorescence Immunofluorescence NNP cord-298503-l60cdllh 106 11 LM LM NNP cord-298503-l60cdllh 106 12 localization localization NN cord-298503-l60cdllh 106 13 of of IN cord-298503-l60cdllh 106 14 p58 p58 NNP cord-298503-l60cdllh 106 15 / / SYM cord-298503-l60cdllh 106 16 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 106 17 in in IN cord-298503-l60cdllh 106 18 baby baby NN cord-298503-l60cdllh 106 19 hamster hamster NN cord-298503-l60cdllh 106 20 kidney kidney NN cord-298503-l60cdllh 106 21 , , , cord-298503-l60cdllh 106 22 ( ( -LRB- cord-298503-l60cdllh 106 23 b b NN cord-298503-l60cdllh 106 24 ) ) -RRB- cord-298503-l60cdllh 106 25 mouse mouse NN cord-298503-l60cdllh 106 26 myeloma myeloma NN cord-298503-l60cdllh 106 27 , , , cord-298503-l60cdllh 107 1 ( ( -LRB- cord-298503-l60cdllh 107 2 c c NN cord-298503-l60cdllh 107 3 ) ) -RRB- cord-298503-l60cdllh 107 4 rat rat NN cord-298503-l60cdllh 107 5 neuroendocrine neuroendocrine NN cord-298503-l60cdllh 107 6 PC12 PC12 NNP cord-298503-l60cdllh 107 7 , , , cord-298503-l60cdllh 107 8 and and CC cord-298503-l60cdllh 107 9 ( ( -LRB- cord-298503-l60cdllh 107 10 d d LS cord-298503-l60cdllh 107 11 ) ) -RRB- cord-298503-l60cdllh 107 12 human human JJ cord-298503-l60cdllh 107 13 HeLa HeLa NNP cord-298503-l60cdllh 107 14 cells cell NNS cord-298503-l60cdllh 107 15 . . . cord-298503-l60cdllh 108 1 The the DT cord-298503-l60cdllh 108 2 protein protein NN cord-298503-l60cdllh 108 3 marks mark VBZ cord-298503-l60cdllh 108 4 the the DT cord-298503-l60cdllh 108 5 IC IC NNP cord-298503-l60cdllh 108 6 elements element NNS cord-298503-l60cdllh 108 7 accumulating accumulate VBG cord-298503-l60cdllh 108 8 in in IN cord-298503-l60cdllh 108 9 the the DT cord-298503-l60cdllh 108 10 perinuclear perinuclear NNP cord-298503-l60cdllh 108 11 Golgi Golgi NNP cord-298503-l60cdllh 108 12 region region NN cord-298503-l60cdllh 108 13 ( ( -LRB- cord-298503-l60cdllh 108 14 asterisks asterisk NNS cord-298503-l60cdllh 108 15 ) ) -RRB- cord-298503-l60cdllh 108 16 , , , cord-298503-l60cdllh 108 17 scattered scatter VBN cord-298503-l60cdllh 108 18 throughout throughout IN cord-298503-l60cdllh 108 19 the the DT cord-298503-l60cdllh 108 20 cytoplasm cytoplasm NN cord-298503-l60cdllh 108 21 , , , cord-298503-l60cdllh 108 22 and and CC cord-298503-l60cdllh 108 23 located locate VBN cord-298503-l60cdllh 108 24 close close RB cord-298503-l60cdllh 108 25 to to IN cord-298503-l60cdllh 108 26 the the DT cord-298503-l60cdllh 108 27 PM pm NN cord-298503-l60cdllh 108 28 ( ( -LRB- cord-298503-l60cdllh 108 29 arrows arrow NNS cord-298503-l60cdllh 108 30 ) ) -RRB- cord-298503-l60cdllh 108 31 . . . cord-298503-l60cdllh 109 1 The the DT cord-298503-l60cdllh 109 2 reticular reticular JJ cord-298503-l60cdllh 109 3 staining staining NN cord-298503-l60cdllh 109 4 indicates indicate VBZ cord-298503-l60cdllh 109 5 the the DT cord-298503-l60cdllh 109 6 ER ER NNP cord-298503-l60cdllh 109 7 pool pool NN cord-298503-l60cdllh 109 8 of of IN cord-298503-l60cdllh 109 9 p58 p58 NNP cord-298503-l60cdllh 109 10 / / SYM cord-298503-l60cdllh 109 11 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 109 12 , , , cord-298503-l60cdllh 109 13 which which WDT cord-298503-l60cdllh 109 14 varies vary VBZ cord-298503-l60cdllh 109 15 in in IN cord-298503-l60cdllh 109 16 the the DT cord-298503-l60cdllh 109 17 different different JJ cord-298503-l60cdllh 109 18 cell cell NN cord-298503-l60cdllh 109 19 types type NNS cord-298503-l60cdllh 109 20 . . . cord-298503-l60cdllh 110 1 Nu Nu NNP cord-298503-l60cdllh 110 2 , , , cord-298503-l60cdllh 110 3 nucleus nucleus NN cord-298503-l60cdllh 110 4 . . . cord-298503-l60cdllh 111 1 Bar bar NN cord-298503-l60cdllh 111 2 : : : cord-298503-l60cdllh 111 3 10 10 CD cord-298503-l60cdllh 111 4 mm mm NN cord-298503-l60cdllh 111 5 . . . cord-298503-l60cdllh 112 1 phosphorylated phosphorylate VBN cord-298503-l60cdllh 112 2 at at IN cord-298503-l60cdllh 112 3 mitosis mitosis NN cord-298503-l60cdllh 112 4 ( ( -LRB- cord-298503-l60cdllh 112 5 Bailly Bailly NNP cord-298503-l60cdllh 112 6 et et NNP cord-298503-l60cdllh 112 7 al al NNP cord-298503-l60cdllh 112 8 . . NNP cord-298503-l60cdllh 112 9 , , , cord-298503-l60cdllh 112 10 1991 1991 CD cord-298503-l60cdllh 112 11 ) ) -RRB- cord-298503-l60cdllh 112 12 , , , cord-298503-l60cdllh 112 13 correlating correlate VBG cord-298503-l60cdllh 112 14 with with IN cord-298503-l60cdllh 112 15 the the DT cord-298503-l60cdllh 112 16 cessation cessation NN cord-298503-l60cdllh 112 17 of of IN cord-298503-l60cdllh 112 18 tubular tubular JJ cord-298503-l60cdllh 112 19 IC IC NNP cord-298503-l60cdllh 112 20 dynamics dynamic NNS cord-298503-l60cdllh 112 21 , , , cord-298503-l60cdllh 112 22 whereas whereas IN cord-298503-l60cdllh 112 23 COPI COPI NNP cord-298503-l60cdllh 112 24 - - HYPH cord-298503-l60cdllh 112 25 mediated mediate VBN cord-298503-l60cdllh 112 26 vesicular vesicular JJ cord-298503-l60cdllh 112 27 transport transport NN cord-298503-l60cdllh 112 28 continues continue VBZ cord-298503-l60cdllh 113 1 ( ( -LRB- cord-298503-l60cdllh 113 2 Marie Marie NNP cord-298503-l60cdllh 113 3 et et NNP cord-298503-l60cdllh 113 4 al al NNP cord-298503-l60cdllh 113 5 . . . cord-298503-l60cdllh 114 1 , , , cord-298503-l60cdllh 114 2 2012 2012 CD cord-298503-l60cdllh 114 3 ) ) -RRB- cord-298503-l60cdllh 114 4 . . . cord-298503-l60cdllh 115 1 Rab1A Rab1A NNS cord-298503-l60cdllh 115 2 can can MD cord-298503-l60cdllh 115 3 functionally functionally RB cord-298503-l60cdllh 115 4 replace replace VB cord-298503-l60cdllh 115 5 Ypt1 Ypt1 NNP cord-298503-l60cdllh 115 6 , , , cord-298503-l60cdllh 115 7 which which WDT cord-298503-l60cdllh 115 8 coordinates coordinate VBZ cord-298503-l60cdllh 115 9 two two CD cord-298503-l60cdllh 115 10 - - HYPH cord-298503-l60cdllh 115 11 way way NN cord-298503-l60cdllh 115 12 ER ER NNP cord-298503-l60cdllh 115 13 - - HYPH cord-298503-l60cdllh 115 14 Golgi Golgi NNP cord-298503-l60cdllh 115 15 trafficking trafficking NN cord-298503-l60cdllh 115 16 in in IN cord-298503-l60cdllh 115 17 the the DT cord-298503-l60cdllh 115 18 yeast yeast NN cord-298503-l60cdllh 115 19 Saccharomyces Saccharomyces NNP cord-298503-l60cdllh 115 20 cerevisiae cerevisiae NNS cord-298503-l60cdllh 115 21 ( ( -LRB- cord-298503-l60cdllh 115 22 Haubruck Haubruck NNP cord-298503-l60cdllh 115 23 et et NNP cord-298503-l60cdllh 115 24 al al NNP cord-298503-l60cdllh 115 25 . . NNP cord-298503-l60cdllh 115 26 1989 1989 CD cord-298503-l60cdllh 115 27 ; ; : cord-298503-l60cdllh 115 28 Segev Segev NNP cord-298503-l60cdllh 115 29 , , , cord-298503-l60cdllh 115 30 2001 2001 CD cord-298503-l60cdllh 115 31 ; ; : cord-298503-l60cdllh 116 1 Kamena Kamena NNP cord-298503-l60cdllh 116 2 et et NNP cord-298503-l60cdllh 116 3 al al NNP cord-298503-l60cdllh 116 4 . . NNP cord-298503-l60cdllh 116 5 , , , cord-298503-l60cdllh 116 6 2008 2008 CD cord-298503-l60cdllh 116 7 ) ) -RRB- cord-298503-l60cdllh 116 8 . . . cord-298503-l60cdllh 117 1 Rab2 Rab2 NNP cord-298503-l60cdllh 117 2 has have VBZ cord-298503-l60cdllh 117 3 been be VBN cord-298503-l60cdllh 117 4 localized localize VBN cord-298503-l60cdllh 117 5 to to IN cord-298503-l60cdllh 117 6 IC IC NNP cord-298503-l60cdllh 117 7 and and CC cord-298503-l60cdllh 117 8 cis cis NNP cord-298503-l60cdllh 117 9 - - HYPH cord-298503-l60cdllh 117 10 Golgi Golgi NNP cord-298503-l60cdllh 117 11 membranes membrane NNS cord-298503-l60cdllh 117 12 ( ( -LRB- cord-298503-l60cdllh 117 13 Chavrier Chavrier NNP cord-298503-l60cdllh 117 14 et et NNP cord-298503-l60cdllh 117 15 al al NNP cord-298503-l60cdllh 117 16 . . NNP cord-298503-l60cdllh 117 17 , , , cord-298503-l60cdllh 117 18 1990 1990 CD cord-298503-l60cdllh 117 19 ; ; : cord-298503-l60cdllh 117 20 Lotti Lotti NNP cord-298503-l60cdllh 117 21 et et NNP cord-298503-l60cdllh 117 22 al al NNP cord-298503-l60cdllh 117 23 . . NNP cord-298503-l60cdllh 117 24 , , , cord-298503-l60cdllh 117 25 1992 1992 CD cord-298503-l60cdllh 117 26 ) ) -RRB- cord-298503-l60cdllh 117 27 and and CC cord-298503-l60cdllh 117 28 proposed propose VBD cord-298503-l60cdllh 117 29 to to TO cord-298503-l60cdllh 117 30 regulate regulate VB cord-298503-l60cdllh 117 31 the the DT cord-298503-l60cdllh 117 32 formation formation NN cord-298503-l60cdllh 117 33 of of IN cord-298503-l60cdllh 117 34 retrograde retrograde JJ cord-298503-l60cdllh 117 35 COPI COPI NNP cord-298503-l60cdllh 117 36 vesicles vesicle NNS cord-298503-l60cdllh 117 37 that that WDT cord-298503-l60cdllh 117 38 contain contain VBP cord-298503-l60cdllh 117 39 p58 p58 NN cord-298503-l60cdllh 117 40 / / SYM cord-298503-l60cdllh 117 41 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 117 42 ( ( -LRB- cord-298503-l60cdllh 117 43 Tisdale Tisdale NNP cord-298503-l60cdllh 117 44 , , , cord-298503-l60cdllh 117 45 1999 1999 CD cord-298503-l60cdllh 117 46 ) ) -RRB- cord-298503-l60cdllh 117 47 . . . cord-298503-l60cdllh 118 1 It -PRON- PRP cord-298503-l60cdllh 118 2 has have VBZ cord-298503-l60cdllh 118 3 also also RB cord-298503-l60cdllh 118 4 been be VBN cord-298503-l60cdllh 118 5 implicated implicate VBN cord-298503-l60cdllh 118 6 in in IN cord-298503-l60cdllh 118 7 the the DT cord-298503-l60cdllh 118 8 recruitment recruitment NN cord-298503-l60cdllh 118 9 of of IN cord-298503-l60cdllh 118 10 the the DT cord-298503-l60cdllh 118 11 motor motor NN cord-298503-l60cdllh 118 12 protein protein NN cord-298503-l60cdllh 118 13 dynein dynein NN cord-298503-l60cdllh 118 14 to to IN cord-298503-l60cdllh 118 15 IC IC NNP cord-298503-l60cdllh 118 16 membranes membrane NNS cord-298503-l60cdllh 118 17 and and CC cord-298503-l60cdllh 118 18 the the DT cord-298503-l60cdllh 118 19 association association NN cord-298503-l60cdllh 118 20 of of IN cord-298503-l60cdllh 118 21 IC IC NNP cord-298503-l60cdllh 118 22 elements element NNS cord-298503-l60cdllh 118 23 with with IN cord-298503-l60cdllh 118 24 MTs MTs NNP cord-298503-l60cdllh 118 25 ( ( -LRB- cord-298503-l60cdllh 118 26 Tisdale Tisdale NNP cord-298503-l60cdllh 118 27 et et NNP cord-298503-l60cdllh 118 28 al al NNP cord-298503-l60cdllh 118 29 . . NNP cord-298503-l60cdllh 118 30 , , , cord-298503-l60cdllh 118 31 2009 2009 CD cord-298503-l60cdllh 118 32 ; ; : cord-298503-l60cdllh 118 33 see see VB cord-298503-l60cdllh 118 34 below below RB cord-298503-l60cdllh 118 35 ) ) -RRB- cord-298503-l60cdllh 118 36 . . . cord-298503-l60cdllh 119 1 Most Most JJS cord-298503-l60cdllh 119 2 of of IN cord-298503-l60cdllh 119 3 the the DT cord-298503-l60cdllh 119 4 known know VBN cord-298503-l60cdllh 119 5 Rab1 rab1 NN cord-298503-l60cdllh 119 6 and and CC cord-298503-l60cdllh 119 7 Rab2 rab2 JJ cord-298503-l60cdllh 119 8 effectors effector NNS cord-298503-l60cdllh 119 9 are be VBP cord-298503-l60cdllh 119 10 cytoplasmically cytoplasmically RB cord-298503-l60cdllh 119 11 oriented orient VBN cord-298503-l60cdllh 119 12 , , , cord-298503-l60cdllh 119 13 long long RB cord-298503-l60cdllh 119 14 coiled coil VBN cord-298503-l60cdllh 119 15 - - HYPH cord-298503-l60cdllh 119 16 coil coil NN cord-298503-l60cdllh 119 17 proteins protein NNS cord-298503-l60cdllh 119 18 , , , cord-298503-l60cdllh 119 19 which which WDT cord-298503-l60cdllh 119 20 function function VBP cord-298503-l60cdllh 119 21 in in IN cord-298503-l60cdllh 119 22 the the DT cord-298503-l60cdllh 119 23 tethering tethering NN cord-298503-l60cdllh 119 24 of of IN cord-298503-l60cdllh 119 25 vesicle vesicle NN cord-298503-l60cdllh 119 26 and and CC cord-298503-l60cdllh 119 27 organelle organelle NN cord-298503-l60cdllh 119 28 membranes membrane NNS cord-298503-l60cdllh 119 29 preceding precede VBG cord-298503-l60cdllh 119 30 their -PRON- PRP$ cord-298503-l60cdllh 119 31 soluble soluble JJ cord-298503-l60cdllh 119 32 NSF NSF NNP cord-298503-l60cdllh 119 33 attachment attachment NN cord-298503-l60cdllh 119 34 protein protein NN cord-298503-l60cdllh 119 35 receptor receptor NN cord-298503-l60cdllh 119 36 ( ( -LRB- cord-298503-l60cdllh 119 37 SNARE)-mediated SNARE)-mediated NNP cord-298503-l60cdllh 119 38 fusion fusion NN cord-298503-l60cdllh 119 39 ( ( -LRB- cord-298503-l60cdllh 119 40 Barnekow Barnekow NNP cord-298503-l60cdllh 119 41 et et NNP cord-298503-l60cdllh 119 42 al al NNP cord-298503-l60cdllh 119 43 . . NNP cord-298503-l60cdllh 119 44 , , , cord-298503-l60cdllh 119 45 2009 2009 CD cord-298503-l60cdllh 119 46 ; ; : cord-298503-l60cdllh 119 47 Sztul Sztul NNP cord-298503-l60cdllh 119 48 and and CC cord-298503-l60cdllh 119 49 Lupashin Lupashin NNP cord-298503-l60cdllh 119 50 , , , cord-298503-l60cdllh 119 51 2009 2009 CD cord-298503-l60cdllh 119 52 ) ) -RRB- cord-298503-l60cdllh 119 53 . . . cord-298503-l60cdllh 120 1 Besides besides IN cord-298503-l60cdllh 120 2 the the DT cord-298503-l60cdllh 120 3 IC IC NNP cord-298503-l60cdllh 120 4 / / SYM cord-298503-l60cdllh 120 5 cis cis NNP cord-298503-l60cdllh 120 6 - - HYPH cord-298503-l60cdllh 120 7 Golgi Golgi NNP cord-298503-l60cdllh 120 8 tethers tether NNS cord-298503-l60cdllh 120 9 GM130 GM130 NNP cord-298503-l60cdllh 120 10 and and CC cord-298503-l60cdllh 120 11 GMAP-210 GMAP-210 NNP cord-298503-l60cdllh 121 1 ( ( -LRB- cord-298503-l60cdllh 121 2 Rios Rios NNP cord-298503-l60cdllh 121 3 et et NNP cord-298503-l60cdllh 121 4 al al NNP cord-298503-l60cdllh 121 5 . . NNP cord-298503-l60cdllh 121 6 , , , cord-298503-l60cdllh 121 7 2004 2004 CD cord-298503-l60cdllh 121 8 ) ) -RRB- cord-298503-l60cdllh 121 9 , , , cord-298503-l60cdllh 121 10 Rab2 Rab2 NNP cord-298503-l60cdllh 121 11 has have VBZ cord-298503-l60cdllh 121 12 been be VBN cord-298503-l60cdllh 121 13 shown show VBN cord-298503-l60cdllh 121 14 to to TO cord-298503-l60cdllh 121 15 interact interact VB cord-298503-l60cdllh 121 16 with with IN cord-298503-l60cdllh 121 17 medialand medialand NNP cord-298503-l60cdllh 121 18 trans trans NNP cord-298503-l60cdllh 121 19 - - NNP cord-298503-l60cdllh 121 20 Golgi Golgi NNP cord-298503-l60cdllh 121 21 tethers tether NNS cord-298503-l60cdllh 121 22 , , , cord-298503-l60cdllh 121 23 suggesting suggest VBG cord-298503-l60cdllh 121 24 a a DT cord-298503-l60cdllh 121 25 more more RBR cord-298503-l60cdllh 121 26 widespread widespread JJ cord-298503-l60cdllh 121 27 function function NN cord-298503-l60cdllh 121 28 ( ( -LRB- cord-298503-l60cdllh 121 29 Short Short NNP cord-298503-l60cdllh 121 30 et et FW cord-298503-l60cdllh 121 31 al al NNP cord-298503-l60cdllh 121 32 . . NNP cord-298503-l60cdllh 121 33 , , , cord-298503-l60cdllh 121 34 2001 2001 CD cord-298503-l60cdllh 121 35 ; ; : cord-298503-l60cdllh 121 36 Sinka Sinka NNP cord-298503-l60cdllh 121 37 et et FW cord-298503-l60cdllh 121 38 al al NNP cord-298503-l60cdllh 121 39 . . NNP cord-298503-l60cdllh 121 40 , , , cord-298503-l60cdllh 121 41 2008 2008 CD cord-298503-l60cdllh 121 42 ) ) -RRB- cord-298503-l60cdllh 121 43 . . . cord-298503-l60cdllh 122 1 The the DT cord-298503-l60cdllh 122 2 Rab1 Rab1 NNP cord-298503-l60cdllh 122 3 effector effector NN cord-298503-l60cdllh 122 4 p115 p115 NNS cord-298503-l60cdllh 122 5 is be VBZ cord-298503-l60cdllh 122 6 functional functional JJ cord-298503-l60cdllh 122 7 already already RB cord-298503-l60cdllh 122 8 at at IN cord-298503-l60cdllh 122 9 the the DT cord-298503-l60cdllh 122 10 peripheral peripheral JJ cord-298503-l60cdllh 122 11 ERES ERES NNP cord-298503-l60cdllh 123 1 ( ( -LRB- cord-298503-l60cdllh 123 2 Alvarez Alvarez NNP cord-298503-l60cdllh 123 3 et et NNP cord-298503-l60cdllh 123 4 al al NNP cord-298503-l60cdllh 123 5 . . NNP cord-298503-l60cdllh 123 6 , , , cord-298503-l60cdllh 123 7 1999 1999 CD cord-298503-l60cdllh 123 8 ) ) -RRB- cord-298503-l60cdllh 123 9 , , , cord-298503-l60cdllh 123 10 while while IN cord-298503-l60cdllh 123 11 GM130 GM130 NNP cord-298503-l60cdllh 123 12 ( ( -LRB- cord-298503-l60cdllh 123 13 bound bind VBN cord-298503-l60cdllh 123 14 to to IN cord-298503-l60cdllh 123 15 its -PRON- PRP$ cord-298503-l60cdllh 123 16 membrane membrane NN cord-298503-l60cdllh 123 17 anchor anchor NN cord-298503-l60cdllh 123 18 GRASP65 GRASP65 NNP cord-298503-l60cdllh 123 19 ) ) -RRB- cord-298503-l60cdllh 123 20 cycles cycle NNS cord-298503-l60cdllh 123 21 between between IN cord-298503-l60cdllh 123 22 central central JJ cord-298503-l60cdllh 123 23 IC IC NNP cord-298503-l60cdllh 123 24 and and CC cord-298503-l60cdllh 123 25 cis cis NNP cord-298503-l60cdllh 123 26 - - HYPH cord-298503-l60cdllh 123 27 Golgi Golgi NNP cord-298503-l60cdllh 123 28 ( ( -LRB- cord-298503-l60cdllh 123 29 Marra Marra NNP cord-298503-l60cdllh 123 30 et et NNP cord-298503-l60cdllh 123 31 al al NNP cord-298503-l60cdllh 123 32 . . NNP cord-298503-l60cdllh 123 33 , , , cord-298503-l60cdllh 123 34 2001 2001 CD cord-298503-l60cdllh 123 35 ) ) -RRB- cord-298503-l60cdllh 123 36 and and CC cord-298503-l60cdllh 123 37 regulates regulate VBZ cord-298503-l60cdllh 123 38 membrane membrane NN cord-298503-l60cdllh 123 39 tethering tether VBG cord-298503-l60cdllh 123 40 at at IN cord-298503-l60cdllh 123 41 a a DT cord-298503-l60cdllh 123 42 later later JJ cord-298503-l60cdllh 123 43 transport transport NN cord-298503-l60cdllh 123 44 step step NN cord-298503-l60cdllh 123 45 ( ( -LRB- cord-298503-l60cdllh 123 46 Alvarez Alvarez NNP cord-298503-l60cdllh 123 47 et et NNP cord-298503-l60cdllh 123 48 al al NNP cord-298503-l60cdllh 123 49 . . . cord-298503-l60cdllh 124 1 , , , cord-298503-l60cdllh 124 2 2001 2001 CD cord-298503-l60cdllh 124 3 ; ; : cord-298503-l60cdllh 124 4 Marra Marra NNP cord-298503-l60cdllh 124 5 et et NNP cord-298503-l60cdllh 124 6 al al NNP cord-298503-l60cdllh 124 7 . . NNP cord-298503-l60cdllh 124 8 , , , cord-298503-l60cdllh 124 9 2007 2007 CD cord-298503-l60cdllh 124 10 ) ) -RRB- cord-298503-l60cdllh 124 11 . . . cord-298503-l60cdllh 125 1 Rab1 Rab1 NNP cord-298503-l60cdllh 125 2 also also RB cord-298503-l60cdllh 125 3 interacts interact VBZ cord-298503-l60cdllh 125 4 with with IN cord-298503-l60cdllh 125 5 the the DT cord-298503-l60cdllh 125 6 transmembrane transmembrane NNP cord-298503-l60cdllh 125 7 tethers tether NNS cord-298503-l60cdllh 125 8 golgin-84 golgin-84 NNS cord-298503-l60cdllh 125 9 and and CC cord-298503-l60cdllh 125 10 giantin giantin NNP cord-298503-l60cdllh 125 11 , , , cord-298503-l60cdllh 125 12 which which WDT cord-298503-l60cdllh 125 13 appear appear VBP cord-298503-l60cdllh 125 14 to to TO cord-298503-l60cdllh 125 15 act act VB cord-298503-l60cdllh 125 16 in in IN cord-298503-l60cdllh 125 17 COPI COPI NNP cord-298503-l60cdllh 125 18 vesicle vesicle NN cord-298503-l60cdllh 125 19 trafficking traffic VBG cord-298503-l60cdllh 125 20 at at IN cord-298503-l60cdllh 125 21 the the DT cord-298503-l60cdllh 125 22 lateral lateral JJ cord-298503-l60cdllh 125 23 rims rim NNS cord-298503-l60cdllh 125 24 of of IN cord-298503-l60cdllh 125 25 the the DT cord-298503-l60cdllh 125 26 Golgi Golgi NNP cord-298503-l60cdllh 125 27 stacks stack NNS cord-298503-l60cdllh 126 1 ( ( -LRB- cord-298503-l60cdllh 126 2 Diao Diao NNP cord-298503-l60cdllh 126 3 et et FW cord-298503-l60cdllh 126 4 al al NNP cord-298503-l60cdllh 126 5 . . NNP cord-298503-l60cdllh 126 6 , , , cord-298503-l60cdllh 126 7 2003 2003 CD cord-298503-l60cdllh 127 1 ; ; : cord-298503-l60cdllh 127 2 Malsam Malsam NNP cord-298503-l60cdllh 127 3 et et NNP cord-298503-l60cdllh 127 4 al al NNP cord-298503-l60cdllh 127 5 . . . cord-298503-l60cdllh 128 1 , , , cord-298503-l60cdllh 128 2 2005 2005 CD cord-298503-l60cdllh 128 3 ; ; : cord-298503-l60cdllh 128 4 Barnekow Barnekow NNP cord-298503-l60cdllh 128 5 et et NNP cord-298503-l60cdllh 128 6 al al NNP cord-298503-l60cdllh 128 7 . . . cord-298503-l60cdllh 129 1 , , , cord-298503-l60cdllh 129 2 2009 2009 CD cord-298503-l60cdllh 129 3 ; ; : cord-298503-l60cdllh 129 4 Munro Munro NNP cord-298503-l60cdllh 129 5 , , , cord-298503-l60cdllh 129 6 2011 2011 CD cord-298503-l60cdllh 129 7 ) ) -RRB- cord-298503-l60cdllh 129 8 . . . cord-298503-l60cdllh 130 1 The the DT cord-298503-l60cdllh 130 2 membrane membrane NN cord-298503-l60cdllh 130 3 fusion fusion NN cord-298503-l60cdllh 130 4 machinery machinery NN cord-298503-l60cdllh 130 5 ( ( -LRB- cord-298503-l60cdllh 130 6 SNARE snare NN cord-298503-l60cdllh 130 7 proteins protein NNS cord-298503-l60cdllh 130 8 ) ) -RRB- cord-298503-l60cdllh 130 9 operating operate VBG cord-298503-l60cdllh 130 10 in in IN cord-298503-l60cdllh 130 11 ER ER NNP cord-298503-l60cdllh 130 12 - - HYPH cord-298503-l60cdllh 130 13 Golgi Golgi NNP cord-298503-l60cdllh 130 14 trafficking trafficking NN cord-298503-l60cdllh 130 15 in in IN cord-298503-l60cdllh 130 16 the the DT cord-298503-l60cdllh 130 17 yeast yeast NN cord-298503-l60cdllh 130 18 Saccharomyces Saccharomyces NNP cord-298503-l60cdllh 130 19 cerevisiae cerevisiae NNS cord-298503-l60cdllh 130 20 has have VBZ cord-298503-l60cdllh 130 21 been be VBN cord-298503-l60cdllh 130 22 well well RB cord-298503-l60cdllh 130 23 characterized characterize VBN cord-298503-l60cdllh 131 1 ( ( -LRB- cord-298503-l60cdllh 131 2 Cai Cai NNP cord-298503-l60cdllh 131 3 et et FW cord-298503-l60cdllh 131 4 al al NNP cord-298503-l60cdllh 131 5 . . NNP cord-298503-l60cdllh 131 6 , , , cord-298503-l60cdllh 131 7 2007 2007 CD cord-298503-l60cdllh 131 8 ; ; : cord-298503-l60cdllh 131 9 Barlowe Barlowe NNP cord-298503-l60cdllh 131 10 and and CC cord-298503-l60cdllh 131 11 Miller Miller NNP cord-298503-l60cdllh 131 12 , , , cord-298503-l60cdllh 131 13 2013 2013 CD cord-298503-l60cdllh 131 14 ) ) -RRB- cord-298503-l60cdllh 131 15 , , , cord-298503-l60cdllh 131 16 whereas whereas IN cord-298503-l60cdllh 131 17 the the DT cord-298503-l60cdllh 131 18 fusion fusion NN cord-298503-l60cdllh 131 19 events event NNS cord-298503-l60cdllh 131 20 that that WDT cord-298503-l60cdllh 131 21 take take VBP cord-298503-l60cdllh 131 22 place place NN cord-298503-l60cdllh 131 23 in in IN cord-298503-l60cdllh 131 24 mammalian mammalian JJ cord-298503-l60cdllh 131 25 cells cell NNS cord-298503-l60cdllh 131 26 remain remain VBP cord-298503-l60cdllh 131 27 enigmatic enigmatic JJ cord-298503-l60cdllh 131 28 . . . cord-298503-l60cdllh 132 1 The the DT cord-298503-l60cdllh 132 2 determination determination NN cord-298503-l60cdllh 132 3 of of IN cord-298503-l60cdllh 132 4 the the DT cord-298503-l60cdllh 132 5 exact exact JJ cord-298503-l60cdllh 132 6 fusion fusion NN cord-298503-l60cdllh 132 7 steps step NNS cord-298503-l60cdllh 132 8 is be VBZ cord-298503-l60cdllh 132 9 complicated complicate VBN cord-298503-l60cdllh 132 10 by by IN cord-298503-l60cdllh 132 11 the the DT cord-298503-l60cdllh 132 12 continuous continuous JJ cord-298503-l60cdllh 132 13 cycling cycling NN cord-298503-l60cdllh 132 14 of of IN cord-298503-l60cdllh 132 15 the the DT cord-298503-l60cdllh 132 16 SNAREs SNAREs NNPS cord-298503-l60cdllh 132 17 in in IN cord-298503-l60cdllh 132 18 COPI COPI NNP cord-298503-l60cdllh 132 19 vesicles vesicle NNS cord-298503-l60cdllh 132 20 ( ( -LRB- cord-298503-l60cdllh 132 21 Hay Hay NNP cord-298503-l60cdllh 132 22 et et FW cord-298503-l60cdllh 132 23 al al NNP cord-298503-l60cdllh 132 24 . . NNP cord-298503-l60cdllh 132 25 , , , cord-298503-l60cdllh 132 26 1998 1998 CD cord-298503-l60cdllh 132 27 ; ; : cord-298503-l60cdllh 132 28 Martinez Martinez NNP cord-298503-l60cdllh 132 29 - - HYPH cord-298503-l60cdllh 132 30 Menárguez Menárguez NNP cord-298503-l60cdllh 132 31 et et NNP cord-298503-l60cdllh 132 32 al al NNP cord-298503-l60cdllh 132 33 . . NNP cord-298503-l60cdllh 132 34 , , , cord-298503-l60cdllh 132 35 2001 2001 CD cord-298503-l60cdllh 132 36 ) ) -RRB- cord-298503-l60cdllh 132 37 . . . cord-298503-l60cdllh 133 1 In in IN cord-298503-l60cdllh 133 2 analogy analogy NN cord-298503-l60cdllh 133 3 to to IN cord-298503-l60cdllh 133 4 yeast yeast NN cord-298503-l60cdllh 133 5 , , , cord-298503-l60cdllh 133 6 Rab1 Rab1 NNP cord-298503-l60cdllh 133 7 ( ( -LRB- cord-298503-l60cdllh 133 8 Ypt1 Ypt1 NNP cord-298503-l60cdllh 133 9 ) ) -RRB- cord-298503-l60cdllh 133 10 has have VBZ cord-298503-l60cdllh 133 11 been be VBN cord-298503-l60cdllh 133 12 suggested suggest VBN cord-298503-l60cdllh 133 13 to to TO cord-298503-l60cdllh 133 14 recruit recruit VB cord-298503-l60cdllh 133 15 p115 p115 NNP cord-298503-l60cdllh 133 16 ( ( -LRB- cord-298503-l60cdllh 133 17 Uso1p uso1p NN cord-298503-l60cdllh 133 18 ) ) -RRB- cord-298503-l60cdllh 133 19 to to IN cord-298503-l60cdllh 133 20 COPII COPII NNP cord-298503-l60cdllh 133 21 vesicles vesicle NNS cord-298503-l60cdllh 133 22 at at IN cord-298503-l60cdllh 133 23 ERES ERES NNP cord-298503-l60cdllh 133 24 ( ( -LRB- cord-298503-l60cdllh 133 25 Allan Allan NNP cord-298503-l60cdllh 133 26 et et NNP cord-298503-l60cdllh 133 27 al al NNP cord-298503-l60cdllh 133 28 . . NNP cord-298503-l60cdllh 133 29 , , , cord-298503-l60cdllh 133 30 2000 2000 CD cord-298503-l60cdllh 133 31 ) ) -RRB- cord-298503-l60cdllh 133 32 , , , cord-298503-l60cdllh 133 33 followed follow VBN cord-298503-l60cdllh 133 34 by by IN cord-298503-l60cdllh 133 35 the the DT cord-298503-l60cdllh 133 36 formation formation NN cord-298503-l60cdllh 133 37 of of IN cord-298503-l60cdllh 133 38 a a DT cord-298503-l60cdllh 133 39 SNARE snare NN cord-298503-l60cdllh 133 40 complex complex NN cord-298503-l60cdllh 133 41 ( ( -LRB- cord-298503-l60cdllh 133 42 Sec22B Sec22B NNP cord-298503-l60cdllh 133 43 , , , cord-298503-l60cdllh 133 44 membrin membrin NNP cord-298503-l60cdllh 133 45 , , , cord-298503-l60cdllh 133 46 Bet1 Bet1 NNP cord-298503-l60cdllh 133 47 and and CC cord-298503-l60cdllh 133 48 syntaxin syntaxin NNP cord-298503-l60cdllh 133 49 5 5 CD cord-298503-l60cdllh 133 50 ) ) -RRB- cord-298503-l60cdllh 133 51 , , , cord-298503-l60cdllh 133 52 which which WDT cord-298503-l60cdllh 133 53 mediates mediate VBZ cord-298503-l60cdllh 133 54 either either CC cord-298503-l60cdllh 133 55 homotypic homotypic JJ cord-298503-l60cdllh 133 56 fusion fusion NN cord-298503-l60cdllh 133 57 of of IN cord-298503-l60cdllh 133 58 COPII COPII NNP cord-298503-l60cdllh 133 59 vesicles vesicle NNS cord-298503-l60cdllh 133 60 or or CC cord-298503-l60cdllh 133 61 their -PRON- PRP$ cord-298503-l60cdllh 133 62 heterotypic heterotypic JJ cord-298503-l60cdllh 133 63 fusion fusion NN cord-298503-l60cdllh 133 64 with with IN cord-298503-l60cdllh 133 65 the the DT cord-298503-l60cdllh 133 66 stationary stationary JJ cord-298503-l60cdllh 133 67 IC IC NNP cord-298503-l60cdllh 133 68 ( ( -LRB- cord-298503-l60cdllh 133 69 Zhang Zhang NNP cord-298503-l60cdllh 133 70 et et NNP cord-298503-l60cdllh 133 71 al al NNP cord-298503-l60cdllh 133 72 . . NNP cord-298503-l60cdllh 133 73 , , , cord-298503-l60cdllh 133 74 1997 1997 CD cord-298503-l60cdllh 133 75 ; ; . cord-298503-l60cdllh 134 1 Xu Xu NNP cord-298503-l60cdllh 134 2 et et NNP cord-298503-l60cdllh 134 3 al al NNP cord-298503-l60cdllh 134 4 . . . cord-298503-l60cdllh 135 1 , , , cord-298503-l60cdllh 135 2 2000 2000 CD cord-298503-l60cdllh 135 3 ; ; : cord-298503-l60cdllh 135 4 see see VB cord-298503-l60cdllh 135 5 below below RB cord-298503-l60cdllh 135 6 ) ) -RRB- cord-298503-l60cdllh 135 7 . . . cord-298503-l60cdllh 136 1 Another another DT cord-298503-l60cdllh 136 2 SNARE snare NN cord-298503-l60cdllh 136 3 complex complex NN cord-298503-l60cdllh 136 4 ( ( -LRB- cord-298503-l60cdllh 136 5 syntaxin syntaxin NNP cord-298503-l60cdllh 136 6 5 5 CD cord-298503-l60cdllh 136 7 , , , cord-298503-l60cdllh 136 8 GS28 GS28 NNP cord-298503-l60cdllh 136 9 , , , cord-298503-l60cdllh 136 10 Bet1 Bet1 NNP cord-298503-l60cdllh 136 11 and and CC cord-298503-l60cdllh 136 12 Ykt6 Ykt6 NNP cord-298503-l60cdllh 136 13 ) ) -RRB- cord-298503-l60cdllh 136 14 is be VBZ cord-298503-l60cdllh 136 15 involved involve VBN cord-298503-l60cdllh 136 16 in in IN cord-298503-l60cdllh 136 17 a a DT cord-298503-l60cdllh 136 18 later later JJ cord-298503-l60cdllh 136 19 cis cis NNP cord-298503-l60cdllh 136 20 - - HYPH cord-298503-l60cdllh 136 21 Golgi Golgi NNP cord-298503-l60cdllh 136 22 transport transport NN cord-298503-l60cdllh 136 23 step step NN cord-298503-l60cdllh 136 24 ( ( -LRB- cord-298503-l60cdllh 136 25 Zhang Zhang NNP cord-298503-l60cdllh 136 26 and and CC cord-298503-l60cdllh 136 27 Hong Hong NNP cord-298503-l60cdllh 136 28 , , , cord-298503-l60cdllh 136 29 2001 2001 CD cord-298503-l60cdllh 136 30 ) ) -RRB- cord-298503-l60cdllh 136 31 . . . cord-298503-l60cdllh 137 1 By by IN cord-298503-l60cdllh 137 2 EM EM NNP cord-298503-l60cdllh 137 3 the the DT cord-298503-l60cdllh 137 4 IC IC NNP cord-298503-l60cdllh 137 5 elements element NNS cord-298503-l60cdllh 137 6 can can MD cord-298503-l60cdllh 137 7 be be VB cord-298503-l60cdllh 137 8 readily readily RB cord-298503-l60cdllh 137 9 distinquished distinquishe VBN cord-298503-l60cdllh 137 10 from from IN cord-298503-l60cdllh 137 11 the the DT cord-298503-l60cdllh 137 12 ER ER NNP cord-298503-l60cdllh 137 13 and and CC cord-298503-l60cdllh 137 14 Golgi Golgi NNP cord-298503-l60cdllh 137 15 , , , cord-298503-l60cdllh 137 16 but but CC cord-298503-l60cdllh 137 17 share share VB cord-298503-l60cdllh 137 18 structural structural JJ cord-298503-l60cdllh 137 19 similarity similarity NN cord-298503-l60cdllh 137 20 with with IN cord-298503-l60cdllh 137 21 endosomes endosome NNS cord-298503-l60cdllh 137 22 . . . cord-298503-l60cdllh 138 1 They -PRON- PRP cord-298503-l60cdllh 138 2 reside reside VBP cord-298503-l60cdllh 138 3 close close RB cord-298503-l60cdllh 138 4 to to IN cord-298503-l60cdllh 138 5 peripheral peripheral JJ cord-298503-l60cdllh 138 6 and and CC cord-298503-l60cdllh 138 7 central central JJ cord-298503-l60cdllh 138 8 ERES ERES NNP cord-298503-l60cdllh 138 9 as as IN cord-298503-l60cdllh 138 10 clusters cluster NNS cord-298503-l60cdllh 138 11 of of IN cord-298503-l60cdllh 138 12 vesicles vesicle NNS cord-298503-l60cdllh 138 13 and and CC cord-298503-l60cdllh 138 14 tubules tubule NNS cord-298503-l60cdllh 138 15 ( ( -LRB- cord-298503-l60cdllh 138 16 VTCs vtc NNS cord-298503-l60cdllh 138 17 ; ; : cord-298503-l60cdllh 138 18 Figure figure NN cord-298503-l60cdllh 138 19 4 4 CD cord-298503-l60cdllh 138 20 ( ( -LRB- cord-298503-l60cdllh 138 21 f f NNP cord-298503-l60cdllh 138 22 ) ) -RRB- cord-298503-l60cdllh 138 23 ) ) -RRB- cord-298503-l60cdllh 138 24 that that WDT cord-298503-l60cdllh 138 25 frequently frequently RB cord-298503-l60cdllh 138 26 contain contain VBP cord-298503-l60cdllh 138 27 COPI COPI NNP cord-298503-l60cdllh 138 28 coats coat NNS cord-298503-l60cdllh 138 29 ( ( -LRB- cord-298503-l60cdllh 138 30 Balch Balch NNP cord-298503-l60cdllh 138 31 et et NNP cord-298503-l60cdllh 138 32 al al NNP cord-298503-l60cdllh 138 33 . . NNP cord-298503-l60cdllh 138 34 , , , cord-298503-l60cdllh 138 35 1994 1994 CD cord-298503-l60cdllh 138 36 ; ; . cord-298503-l60cdllh 139 1 Bannykh Bannykh NNP cord-298503-l60cdllh 139 2 et et NNP cord-298503-l60cdllh 139 3 al al NNP cord-298503-l60cdllh 139 4 . . . cord-298503-l60cdllh 140 1 , , , cord-298503-l60cdllh 140 2 1996 1996 CD cord-298503-l60cdllh 140 3 ; ; : cord-298503-l60cdllh 140 4 Martínez Martínez NNP cord-298503-l60cdllh 140 5 - - HYPH cord-298503-l60cdllh 140 6 Menárguez Menárguez NNP cord-298503-l60cdllh 140 7 et et NNP cord-298503-l60cdllh 140 8 al al NNP cord-298503-l60cdllh 140 9 . . NNP cord-298503-l60cdllh 140 10 , , , cord-298503-l60cdllh 140 11 1999 1999 CD cord-298503-l60cdllh 140 12 ) ) -RRB- cord-298503-l60cdllh 140 13 . . . cord-298503-l60cdllh 141 1 However however RB cord-298503-l60cdllh 141 2 , , , cord-298503-l60cdllh 141 3 they -PRON- PRP cord-298503-l60cdllh 141 4 display display VBP cord-298503-l60cdllh 141 5 considerable considerable JJ cord-298503-l60cdllh 141 6 size size NN cord-298503-l60cdllh 141 7 heterogeneity heterogeneity NN cord-298503-l60cdllh 141 8 ( ( -LRB- cord-298503-l60cdllh 141 9 Ying Ying NNP cord-298503-l60cdllh 141 10 et et FW cord-298503-l60cdllh 141 11 al al NNP cord-298503-l60cdllh 141 12 . . NNP cord-298503-l60cdllh 141 13 , , , cord-298503-l60cdllh 141 14 2000 2000 CD cord-298503-l60cdllh 141 15 ) ) -RRB- cord-298503-l60cdllh 141 16 and and CC cord-298503-l60cdllh 141 17 also also RB cord-298503-l60cdllh 141 18 include include VBP cord-298503-l60cdllh 141 19 large large JJ cord-298503-l60cdllh 141 20 saccules saccule NNS cord-298503-l60cdllh 141 21 that that WDT cord-298503-l60cdllh 141 22 are be VBP cord-298503-l60cdllh 141 23 found find VBN cord-298503-l60cdllh 141 24 within within IN cord-298503-l60cdllh 141 25 the the DT cord-298503-l60cdllh 141 26 membrane membrane NN cord-298503-l60cdllh 141 27 clusters cluster NNS cord-298503-l60cdllh 141 28 , , , cord-298503-l60cdllh 141 29 free free JJ cord-298503-l60cdllh 141 30 in in IN cord-298503-l60cdllh 141 31 the the DT cord-298503-l60cdllh 141 32 cytoplasm cytoplasm NN cord-298503-l60cdllh 141 33 , , , cord-298503-l60cdllh 141 34 or or CC cord-298503-l60cdllh 141 35 at at IN cord-298503-l60cdllh 141 36 the the DT cord-298503-l60cdllh 141 37 cis cis NN cord-298503-l60cdllh 141 38 - - HYPH cord-298503-l60cdllh 141 39 face face NN cord-298503-l60cdllh 141 40 of of IN cord-298503-l60cdllh 141 41 the the DT cord-298503-l60cdllh 141 42 Golgi Golgi NNP cord-298503-l60cdllh 141 43 stacks stack NNS cord-298503-l60cdllh 141 44 ( ( -LRB- cord-298503-l60cdllh 141 45 Saraste Saraste NNP cord-298503-l60cdllh 141 46 and and CC cord-298503-l60cdllh 141 47 Svensson Svensson NNP cord-298503-l60cdllh 141 48 , , , cord-298503-l60cdllh 141 49 1991 1991 CD cord-298503-l60cdllh 141 50 ; ; : cord-298503-l60cdllh 141 51 Lahtinen Lahtinen NNP cord-298503-l60cdllh 141 52 et et NNP cord-298503-l60cdllh 141 53 al al NNP cord-298503-l60cdllh 141 54 . . . cord-298503-l60cdllh 142 1 , , , cord-298503-l60cdllh 142 2 1992 1992 CD cord-298503-l60cdllh 142 3 , , , cord-298503-l60cdllh 142 4 Connolly Connolly NNP cord-298503-l60cdllh 142 5 et et NNP cord-298503-l60cdllh 142 6 al al NNP cord-298503-l60cdllh 142 7 . . . cord-298503-l60cdllh 143 1 , , , cord-298503-l60cdllh 143 2 1994 1994 CD cord-298503-l60cdllh 144 1 Stinchcombe Stinchcombe NNP cord-298503-l60cdllh 144 2 et et NNP cord-298503-l60cdllh 144 3 al al NNP cord-298503-l60cdllh 144 4 . . NNP cord-298503-l60cdllh 144 5 , , , cord-298503-l60cdllh 144 6 1995 1995 CD cord-298503-l60cdllh 144 7 ; ; : cord-298503-l60cdllh 145 1 Ladinsky Ladinsky NNP cord-298503-l60cdllh 145 2 et et NNP cord-298503-l60cdllh 145 3 al al NNP cord-298503-l60cdllh 145 4 . . NNP cord-298503-l60cdllh 145 5 , , , cord-298503-l60cdllh 145 6 1999 1999 CD cord-298503-l60cdllh 145 7 ; ; : cord-298503-l60cdllh 145 8 Fan Fan NNP cord-298503-l60cdllh 145 9 et et NNP cord-298503-l60cdllh 145 10 al al NNP cord-298503-l60cdllh 145 11 . . NNP cord-298503-l60cdllh 145 12 , , , cord-298503-l60cdllh 145 13 2003 2003 CD cord-298503-l60cdllh 146 1 ; ; : cord-298503-l60cdllh 146 2 Figures figure NNS cord-298503-l60cdllh 146 3 4(a)-4(e 4(a)-4(e CD cord-298503-l60cdllh 146 4 ) ) -RRB- cord-298503-l60cdllh 146 5 ) ) -RRB- cord-298503-l60cdllh 146 6 . . . cord-298503-l60cdllh 147 1 These these DT cord-298503-l60cdllh 147 2 pleiomorphic pleiomorphic JJ cord-298503-l60cdllh 147 3 saccules saccule NNS cord-298503-l60cdllh 147 4 can can MD cord-298503-l60cdllh 147 5 accommodate accommodate VB cord-298503-l60cdllh 147 6 large large JJ cord-298503-l60cdllh 147 7 - - HYPH cord-298503-l60cdllh 147 8 sized sized JJ cord-298503-l60cdllh 147 9 cargo cargo NN cord-298503-l60cdllh 147 10 , , , cord-298503-l60cdllh 147 11 such such JJ cord-298503-l60cdllh 147 12 as as IN cord-298503-l60cdllh 147 13 procollagen procollagen NNP cord-298503-l60cdllh 147 14 or or CC cord-298503-l60cdllh 147 15 lumenal lumenal NNP cord-298503-l60cdllh 147 16 protein protein NN cord-298503-l60cdllh 147 17 aggregates aggregate NNS cord-298503-l60cdllh 148 1 ( ( -LRB- cord-298503-l60cdllh 148 2 Volchuk Volchuk NNP cord-298503-l60cdllh 148 3 et et NNP cord-298503-l60cdllh 148 4 al al NNP cord-298503-l60cdllh 148 5 . . NNP cord-298503-l60cdllh 148 6 , , , cord-298503-l60cdllh 148 7 2000 2000 CD cord-298503-l60cdllh 149 1 ; ; : cord-298503-l60cdllh 149 2 Trucco Trucco NNP cord-298503-l60cdllh 149 3 et et FW cord-298503-l60cdllh 149 4 al al NNP cord-298503-l60cdllh 149 5 . . NNP cord-298503-l60cdllh 149 6 , , , cord-298503-l60cdllh 149 7 2004 2004 CD cord-298503-l60cdllh 149 8 ; ; : cord-298503-l60cdllh 149 9 Zuber Zuber NNP cord-298503-l60cdllh 149 10 et et NNP cord-298503-l60cdllh 149 11 al al NNP cord-298503-l60cdllh 149 12 . . NNP cord-298503-l60cdllh 149 13 , , , cord-298503-l60cdllh 149 14 2004 2004 CD cord-298503-l60cdllh 149 15 ) ) -RRB- cord-298503-l60cdllh 149 16 , , , cord-298503-l60cdllh 149 17 and and CC cord-298503-l60cdllh 149 18 based base VBN cord-298503-l60cdllh 149 19 on on IN cord-298503-l60cdllh 149 20 correlative correlative JJ cord-298503-l60cdllh 149 21 microscopy microscopy NNS cord-298503-l60cdllh 149 22 ( ( -LRB- cord-298503-l60cdllh 149 23 LM LM NNP cord-298503-l60cdllh 149 24 / / SYM cord-298503-l60cdllh 149 25 EM EM NNP cord-298503-l60cdllh 149 26 ) ) -RRB- cord-298503-l60cdllh 149 27 correspond correspond VBP cord-298503-l60cdllh 149 28 to to IN cord-298503-l60cdllh 149 29 many many JJ cord-298503-l60cdllh 149 30 of of IN cord-298503-l60cdllh 149 31 the the DT cord-298503-l60cdllh 149 32 mobile mobile JJ cord-298503-l60cdllh 149 33 carriers carrier NNS cord-298503-l60cdllh 149 34 that that WDT cord-298503-l60cdllh 149 35 are be VBP cord-298503-l60cdllh 149 36 visible visible JJ cord-298503-l60cdllh 149 37 in in IN cord-298503-l60cdllh 149 38 living live VBG cord-298503-l60cdllh 149 39 cells cell NNS cord-298503-l60cdllh 150 1 ( ( -LRB- cord-298503-l60cdllh 150 2 Mironov Mironov NNP cord-298503-l60cdllh 150 3 et et FW cord-298503-l60cdllh 150 4 al al NNP cord-298503-l60cdllh 150 5 . . NNP cord-298503-l60cdllh 150 6 , , , cord-298503-l60cdllh 150 7 2003 2003 CD cord-298503-l60cdllh 150 8 ) ) -RRB- cord-298503-l60cdllh 150 9 . . . cord-298503-l60cdllh 151 1 Like like IN cord-298503-l60cdllh 151 2 endosomes endosome NNS cord-298503-l60cdllh 151 3 , , , cord-298503-l60cdllh 151 4 they -PRON- PRP cord-298503-l60cdllh 151 5 extend extend VBP cord-298503-l60cdllh 151 6 narrow narrow JJ cord-298503-l60cdllh 151 7 tubules tubule NNS cord-298503-l60cdllh 151 8 and and CC cord-298503-l60cdllh 151 9 also also RB cord-298503-l60cdllh 151 10 bind bind VB cord-298503-l60cdllh 151 11 COPI COPI NNP cord-298503-l60cdllh 151 12 coats coat NNS cord-298503-l60cdllh 151 13 , , , cord-298503-l60cdllh 151 14 indicating indicate VBG cord-298503-l60cdllh 151 15 that that IN cord-298503-l60cdllh 151 16 they -PRON- PRP cord-298503-l60cdllh 151 17 represent represent VBP cord-298503-l60cdllh 151 18 sites site NNS cord-298503-l60cdllh 151 19 for for IN cord-298503-l60cdllh 151 20 vesicle vesicle NN cord-298503-l60cdllh 151 21 budding budding NN cord-298503-l60cdllh 151 22 ( ( -LRB- cord-298503-l60cdllh 152 1 Saraste Saraste NNP cord-298503-l60cdllh 152 2 and and CC cord-298503-l60cdllh 152 3 Kuismanen Kuismanen NNP cord-298503-l60cdllh 152 4 , , , cord-298503-l60cdllh 152 5 1984 1984 CD cord-298503-l60cdllh 152 6 ; ; : cord-298503-l60cdllh 152 7 Volchuk Volchuk NNP cord-298503-l60cdllh 152 8 et et NNP cord-298503-l60cdllh 152 9 al al NNP cord-298503-l60cdllh 152 10 . . NNP cord-298503-l60cdllh 152 11 , , , cord-298503-l60cdllh 152 12 2000 2000 CD cord-298503-l60cdllh 152 13 ; ; : cord-298503-l60cdllh 153 1 Horstman Horstman NNP cord-298503-l60cdllh 153 2 et et NNP cord-298503-l60cdllh 153 3 al al NNP cord-298503-l60cdllh 153 4 . . . cord-298503-l60cdllh 154 1 , , , cord-298503-l60cdllh 154 2 2002 2002 CD cord-298503-l60cdllh 154 3 ; ; : cord-298503-l60cdllh 154 4 Figures figure NNS cord-298503-l60cdllh 154 5 4(c 4(c CD cord-298503-l60cdllh 154 6 ) ) -RRB- cord-298503-l60cdllh 154 7 and and CC cord-298503-l60cdllh 154 8 4(d 4(d CD cord-298503-l60cdllh 154 9 ) ) -RRB- cord-298503-l60cdllh 154 10 ) ) -RRB- cord-298503-l60cdllh 154 11 . . . cord-298503-l60cdllh 155 1 The the DT cord-298503-l60cdllh 155 2 hypertrophy hypertrophy NN cord-298503-l60cdllh 155 3 of of IN cord-298503-l60cdllh 155 4 the the DT cord-298503-l60cdllh 155 5 saccular saccular JJ cord-298503-l60cdllh 155 6 domains domain NNS cord-298503-l60cdllh 155 7 most most RBS cord-298503-l60cdllh 155 8 likely likely RB cord-298503-l60cdllh 155 9 gives give VBZ cord-298503-l60cdllh 155 10 rise rise NN cord-298503-l60cdllh 155 11 to to IN cord-298503-l60cdllh 155 12 the the DT cord-298503-l60cdllh 155 13 pre pre JJ cord-298503-l60cdllh 155 14 - - JJ cord-298503-l60cdllh 155 15 Golgi golgi JJ cord-298503-l60cdllh 155 16 vacuoles vacuole NNS cord-298503-l60cdllh 155 17 seen see VBN cord-298503-l60cdllh 155 18 in in IN cord-298503-l60cdllh 155 19 cells cell NNS cord-298503-l60cdllh 155 20 kept keep VBN cord-298503-l60cdllh 155 21 at at IN cord-298503-l60cdllh 155 22 15 15 CD cord-298503-l60cdllh 155 23 1C 1c NN cord-298503-l60cdllh 155 24 ( ( -LRB- cord-298503-l60cdllh 155 25 Saraste Saraste NNP cord-298503-l60cdllh 155 26 and and CC cord-298503-l60cdllh 155 27 Kuismanen Kuismanen NNP cord-298503-l60cdllh 155 28 , , , cord-298503-l60cdllh 155 29 1992 1992 CD cord-298503-l60cdllh 155 30 ; ; : cord-298503-l60cdllh 155 31 Trucco Trucco NNP cord-298503-l60cdllh 155 32 et et FW cord-298503-l60cdllh 155 33 al al NNP cord-298503-l60cdllh 155 34 . . NNP cord-298503-l60cdllh 155 35 , , , cord-298503-l60cdllh 155 36 2004 2004 CD cord-298503-l60cdllh 155 37 ) ) -RRB- cord-298503-l60cdllh 155 38 . . . cord-298503-l60cdllh 156 1 LM LM NNP cord-298503-l60cdllh 156 2 shows show VBZ cord-298503-l60cdllh 156 3 the the DT cord-298503-l60cdllh 156 4 division division NN cord-298503-l60cdllh 156 5 of of IN cord-298503-l60cdllh 156 6 the the DT cord-298503-l60cdllh 156 7 IC IC NNP cord-298503-l60cdllh 156 8 into into IN cord-298503-l60cdllh 156 9 globular globular JJ cord-298503-l60cdllh 156 10 and and CC cord-298503-l60cdllh 156 11 tubular tubular JJ cord-298503-l60cdllh 156 12 domains domain NNS cord-298503-l60cdllh 156 13 ( ( -LRB- cord-298503-l60cdllh 156 14 Presley Presley NNP cord-298503-l60cdllh 156 15 et et NNP cord-298503-l60cdllh 156 16 al al NNP cord-298503-l60cdllh 156 17 . . NNP cord-298503-l60cdllh 156 18 , , , cord-298503-l60cdllh 156 19 1998 1998 CD cord-298503-l60cdllh 156 20 ) ) -RRB- cord-298503-l60cdllh 156 21 . . . cord-298503-l60cdllh 157 1 The the DT cord-298503-l60cdllh 157 2 former former JJ cord-298503-l60cdllh 157 3 contain contain VBP cord-298503-l60cdllh 157 4 anterograde anterograde JJ cord-298503-l60cdllh 157 5 cargo cargo NN cord-298503-l60cdllh 157 6 , , , cord-298503-l60cdllh 157 7 cargo cargo NN cord-298503-l60cdllh 157 8 receptors receptor NNS cord-298503-l60cdllh 157 9 and and CC cord-298503-l60cdllh 157 10 COPI COPI NNP cord-298503-l60cdllh 157 11 coats coat NNS cord-298503-l60cdllh 157 12 , , , cord-298503-l60cdllh 157 13 most most RBS cord-298503-l60cdllh 157 14 likely likely RB cord-298503-l60cdllh 157 15 corresponding correspond VBG cord-298503-l60cdllh 157 16 to to IN cord-298503-l60cdllh 157 17 individual individual JJ cord-298503-l60cdllh 157 18 VTCs vtc NNS cord-298503-l60cdllh 157 19 or or CC cord-298503-l60cdllh 157 20 free free JJ cord-298503-l60cdllh 157 21 saccules saccule NNS cord-298503-l60cdllh 157 22 , , , cord-298503-l60cdllh 157 23 while while IN cord-298503-l60cdllh 157 24 the the DT cord-298503-l60cdllh 157 25 latter latter JJ cord-298503-l60cdllh 157 26 are be VBP cord-298503-l60cdllh 157 27 highlighted highlight VBN cord-298503-l60cdllh 157 28 by by IN cord-298503-l60cdllh 157 29 Rab1A Rab1A NNS cord-298503-l60cdllh 158 1 ( ( -LRB- cord-298503-l60cdllh 158 2 Sannerud Sannerud NNP cord-298503-l60cdllh 158 3 et et NNP cord-298503-l60cdllh 158 4 al al NNP cord-298503-l60cdllh 158 5 . . NNP cord-298503-l60cdllh 158 6 , , , cord-298503-l60cdllh 158 7 2006 2006 CD cord-298503-l60cdllh 158 8 ) ) -RRB- cord-298503-l60cdllh 158 9 . . . cord-298503-l60cdllh 159 1 The the DT cord-298503-l60cdllh 159 2 tubules tubule NNS cord-298503-l60cdllh 159 3 extend extend VBP cord-298503-l60cdllh 159 4 from from IN cord-298503-l60cdllh 159 5 the the DT cord-298503-l60cdllh 159 6 globular globular JJ cord-298503-l60cdllh 159 7 domains domain NNS cord-298503-l60cdllh 159 8 ( ( -LRB- cord-298503-l60cdllh 159 9 Figure figure NN cord-298503-l60cdllh 159 10 5 5 CD cord-298503-l60cdllh 159 11 ) ) -RRB- cord-298503-l60cdllh 159 12 . . . cord-298503-l60cdllh 160 1 Some some DT cord-298503-l60cdllh 160 2 of of IN cord-298503-l60cdllh 160 3 them -PRON- PRP cord-298503-l60cdllh 160 4 contain contain VBP cord-298503-l60cdllh 160 5 recycling recycling NN cord-298503-l60cdllh 160 6 proteins protein NNS cord-298503-l60cdllh 160 7 , , , cord-298503-l60cdllh 160 8 but but CC cord-298503-l60cdllh 160 9 lack lack JJ cord-298503-l60cdllh 160 10 anterograde anterograde JJ cord-298503-l60cdllh 160 11 cargo cargo NN cord-298503-l60cdllh 160 12 , , , cord-298503-l60cdllh 160 13 indicating indicate VBG cord-298503-l60cdllh 160 14 that that IN cord-298503-l60cdllh 160 15 they -PRON- PRP cord-298503-l60cdllh 160 16 function function VBP cord-298503-l60cdllh 160 17 in in IN cord-298503-l60cdllh 160 18 retrograde retrograde JJ cord-298503-l60cdllh 160 19 transport transport NN cord-298503-l60cdllh 161 1 ( ( -LRB- cord-298503-l60cdllh 161 2 Palokangas Palokangas NNP cord-298503-l60cdllh 161 3 et et NNP cord-298503-l60cdllh 161 4 al al NNP cord-298503-l60cdllh 161 5 . . NNP cord-298503-l60cdllh 161 6 , , , cord-298503-l60cdllh 161 7 1998 1998 CD cord-298503-l60cdllh 161 8 ; ; : cord-298503-l60cdllh 161 9 Simpson Simpson NNP cord-298503-l60cdllh 161 10 et et NNP cord-298503-l60cdllh 161 11 al al NNP cord-298503-l60cdllh 161 12 . . NNP cord-298503-l60cdllh 161 13 , , , cord-298503-l60cdllh 161 14 2006 2006 CD cord-298503-l60cdllh 161 15 ) ) -RRB- cord-298503-l60cdllh 161 16 . . . cord-298503-l60cdllh 162 1 However however RB cord-298503-l60cdllh 162 2 , , , cord-298503-l60cdllh 162 3 under under IN cord-298503-l60cdllh 162 4 synchronized synchronize VBN cord-298503-l60cdllh 162 5 conditions condition NNS cord-298503-l60cdllh 162 6 cargo cargo NN cord-298503-l60cdllh 162 7 is be VBZ cord-298503-l60cdllh 162 8 also also RB cord-298503-l60cdllh 162 9 detected detect VBN cord-298503-l60cdllh 162 10 in in IN cord-298503-l60cdllh 162 11 the the DT cord-298503-l60cdllh 162 12 tubular tubular JJ cord-298503-l60cdllh 162 13 domain domain NN cord-298503-l60cdllh 162 14 , , , cord-298503-l60cdllh 162 15 due due JJ cord-298503-l60cdllh 162 16 to to IN cord-298503-l60cdllh 162 17 overload overload NN cord-298503-l60cdllh 162 18 or or CC cord-298503-l60cdllh 162 19 the the DT cord-298503-l60cdllh 162 20 existence existence NN cord-298503-l60cdllh 162 21 of of IN cord-298503-l60cdllh 162 22 different different JJ cord-298503-l60cdllh 162 23 types type NNS cord-298503-l60cdllh 162 24 of of IN cord-298503-l60cdllh 162 25 IC IC NNP cord-298503-l60cdllh 162 26 tubules tubule NNS cord-298503-l60cdllh 162 27 ( ( -LRB- cord-298503-l60cdllh 162 28 Figure figure NN cord-298503-l60cdllh 162 29 6 6 CD cord-298503-l60cdllh 162 30 ) ) -RRB- cord-298503-l60cdllh 162 31 . . . cord-298503-l60cdllh 163 1 For for IN cord-298503-l60cdllh 163 2 example example NN cord-298503-l60cdllh 163 3 , , , cord-298503-l60cdllh 163 4 incubation incubation NN cord-298503-l60cdllh 163 5 of of IN cord-298503-l60cdllh 163 6 cells cell NNS cord-298503-l60cdllh 163 7 at at IN cord-298503-l60cdllh 163 8 15 15 CD cord-298503-l60cdllh 163 9 - - SYM cord-298503-l60cdllh 163 10 16 16 CD cord-298503-l60cdllh 163 11 1C 1c NN cord-298503-l60cdllh 163 12 inhibits inhibit VBZ cord-298503-l60cdllh 163 13 the the DT cord-298503-l60cdllh 163 14 formation formation NN cord-298503-l60cdllh 163 15 of of IN cord-298503-l60cdllh 163 16 IC IC NNP cord-298503-l60cdllh 163 17 tubules tubule NNS cord-298503-l60cdllh 163 18 , , , cord-298503-l60cdllh 163 19 but but CC cord-298503-l60cdllh 163 20 causes cause VBZ cord-298503-l60cdllh 163 21 the the DT cord-298503-l60cdllh 163 22 expansion expansion NN cord-298503-l60cdllh 163 23 of of IN cord-298503-l60cdllh 163 24 the the DT cord-298503-l60cdllh 163 25 globular globular JJ cord-298503-l60cdllh 163 26 domain domain NN cord-298503-l60cdllh 163 27 , , , cord-298503-l60cdllh 163 28 while while IN cord-298503-l60cdllh 163 29 the the DT cord-298503-l60cdllh 163 30 shift shift NN cord-298503-l60cdllh 163 31 of of IN cord-298503-l60cdllh 163 32 cells cell NNS cord-298503-l60cdllh 163 33 to to IN cord-298503-l60cdllh 163 34 37 37 CD cord-298503-l60cdllh 163 35 1C 1c NN cord-298503-l60cdllh 163 36 generates generate VBZ cord-298503-l60cdllh 163 37 tubular tubular JJ cord-298503-l60cdllh 163 38 networks network NNS cord-298503-l60cdllh 163 39 containing contain VBG cord-298503-l60cdllh 163 40 both both CC cord-298503-l60cdllh 163 41 antero antero NNP cord-298503-l60cdllh 163 42 - - : cord-298503-l60cdllh 163 43 and and CC cord-298503-l60cdllh 163 44 retrograde retrograde JJ cord-298503-l60cdllh 163 45 markers marker NNS cord-298503-l60cdllh 163 46 ( ( -LRB- cord-298503-l60cdllh 163 47 Blum Blum NNP cord-298503-l60cdllh 163 48 et et NNP cord-298503-l60cdllh 163 49 al al NNP cord-298503-l60cdllh 163 50 . . NNP cord-298503-l60cdllh 163 51 , , , cord-298503-l60cdllh 163 52 2000 2000 CD cord-298503-l60cdllh 163 53 ; ; : cord-298503-l60cdllh 163 54 Ben Ben NNP cord-298503-l60cdllh 163 55 - - HYPH cord-298503-l60cdllh 163 56 Takaya Takaya NNP cord-298503-l60cdllh 163 57 et et NNP cord-298503-l60cdllh 163 58 al al NNP cord-298503-l60cdllh 163 59 . . NNP cord-298503-l60cdllh 163 60 , , , cord-298503-l60cdllh 163 61 2005 2005 CD cord-298503-l60cdllh 163 62 ; ; : cord-298503-l60cdllh 163 63 Simpson Simpson NNP cord-298503-l60cdllh 163 64 et et NNP cord-298503-l60cdllh 163 65 al al NNP cord-298503-l60cdllh 163 66 . . NNP cord-298503-l60cdllh 163 67 , , , cord-298503-l60cdllh 163 68 2006 2006 CD cord-298503-l60cdllh 163 69 ) ) -RRB- cord-298503-l60cdllh 163 70 . . . cord-298503-l60cdllh 164 1 Proliferation proliferation NN cord-298503-l60cdllh 164 2 of of IN cord-298503-l60cdllh 164 3 the the DT cord-298503-l60cdllh 164 4 tubules tubule NNS cord-298503-l60cdllh 164 5 is be VBZ cord-298503-l60cdllh 164 6 induced induce VBN cord-298503-l60cdllh 164 7 when when WRB cord-298503-l60cdllh 164 8 COPI COPI NNP cord-298503-l60cdllh 164 9 function function NN cord-298503-l60cdllh 164 10 is be VBZ cord-298503-l60cdllh 164 11 compromised compromise VBN cord-298503-l60cdllh 164 12 ( ( -LRB- cord-298503-l60cdllh 164 13 Szul Szul NNP cord-298503-l60cdllh 164 14 et et NNP cord-298503-l60cdllh 164 15 al al NNP cord-298503-l60cdllh 164 16 . . NNP cord-298503-l60cdllh 164 17 , , , cord-298503-l60cdllh 164 18 2007 2007 CD cord-298503-l60cdllh 164 19 ; ; : cord-298503-l60cdllh 164 20 Marie Marie NNP cord-298503-l60cdllh 164 21 et et NNP cord-298503-l60cdllh 164 22 al al NNP cord-298503-l60cdllh 164 23 . . . cord-298503-l60cdllh 165 1 , , , cord-298503-l60cdllh 165 2 2009 2009 CD cord-298503-l60cdllh 165 3 ; ; : cord-298503-l60cdllh 165 4 Ben Ben NNP cord-298503-l60cdllh 165 5 - - HYPH cord-298503-l60cdllh 165 6 Takaya Takaya NNP cord-298503-l60cdllh 165 7 et et NNP cord-298503-l60cdllh 165 8 al al NNP cord-298503-l60cdllh 165 9 . . NNP cord-298503-l60cdllh 165 10 , , , cord-298503-l60cdllh 165 11 2010 2010 CD cord-298503-l60cdllh 165 12 ; ; : cord-298503-l60cdllh 165 13 Tomás Tomás NNP cord-298503-l60cdllh 165 14 et et NNP cord-298503-l60cdllh 165 15 al al NNP cord-298503-l60cdllh 165 16 . . NNP cord-298503-l60cdllh 165 17 , , , cord-298503-l60cdllh 165 18 2010 2010 CD cord-298503-l60cdllh 166 1 ; ; : cord-298503-l60cdllh 166 2 Hamlin Hamlin NNP cord-298503-l60cdllh 166 3 et et NNP cord-298503-l60cdllh 166 4 al al NNP cord-298503-l60cdllh 166 5 . . NNP cord-298503-l60cdllh 166 6 , , , cord-298503-l60cdllh 166 7 2014 2014 CD cord-298503-l60cdllh 166 8 ) ) -RRB- cord-298503-l60cdllh 166 9 , , , cord-298503-l60cdllh 166 10 but but CC cord-298503-l60cdllh 166 11 also also RB cord-298503-l60cdllh 166 12 occurs occur VBZ cord-298503-l60cdllh 166 13 under under IN cord-298503-l60cdllh 166 14 physiological physiological JJ cord-298503-l60cdllh 166 15 conditions condition NNS cord-298503-l60cdllh 166 16 . . . cord-298503-l60cdllh 167 1 In in IN cord-298503-l60cdllh 167 2 differentiating differentiate VBG cord-298503-l60cdllh 167 3 neuroendocrine neuroendocrine JJ cord-298503-l60cdllh 167 4 PC12 PC12 NNP cord-298503-l60cdllh 167 5 cells cell NNS cord-298503-l60cdllh 167 6 the the DT cord-298503-l60cdllh 167 7 Rab1A rab1a NN cord-298503-l60cdllh 167 8 - - HYPH cord-298503-l60cdllh 167 9 positive positive JJ cord-298503-l60cdllh 167 10 tubular tubular JJ cord-298503-l60cdllh 167 11 IC ic NN cord-298503-l60cdllh 167 12 domain domain NN cord-298503-l60cdllh 167 13 expands expand VBZ cord-298503-l60cdllh 167 14 and and CC cord-298503-l60cdllh 167 15 the the DT cord-298503-l60cdllh 167 16 tubules tubule NNS cord-298503-l60cdllh 167 17 move move VBP cord-298503-l60cdllh 167 18 from from IN cord-298503-l60cdllh 167 19 the the DT cord-298503-l60cdllh 167 20 cell cell NN cord-298503-l60cdllh 167 21 body body NN cord-298503-l60cdllh 167 22 to to IN cord-298503-l60cdllh 167 23 the the DT cord-298503-l60cdllh 167 24 forming form VBG cord-298503-l60cdllh 167 25 neurites neurite NNS cord-298503-l60cdllh 167 26 accumulating accumulate VBG cord-298503-l60cdllh 167 27 in in IN cord-298503-l60cdllh 167 28 their -PRON- PRP$ cord-298503-l60cdllh 167 29 growth growth NN cord-298503-l60cdllh 167 30 cones cone NNS cord-298503-l60cdllh 167 31 ( ( -LRB- cord-298503-l60cdllh 167 32 Sannerud Sannerud NNP cord-298503-l60cdllh 167 33 et et NNP cord-298503-l60cdllh 167 34 al al NNP cord-298503-l60cdllh 167 35 . . NNP cord-298503-l60cdllh 167 36 , , , cord-298503-l60cdllh 167 37 2006 2006 CD cord-298503-l60cdllh 167 38 ; ; : cord-298503-l60cdllh 167 39 Figure figure NN cord-298503-l60cdllh 167 40 5 5 CD cord-298503-l60cdllh 167 41 ) ) -RRB- cord-298503-l60cdllh 167 42 . . . cord-298503-l60cdllh 168 1 An an DT cord-298503-l60cdllh 168 2 analogous analogous JJ cord-298503-l60cdllh 168 3 pathway pathway NN cord-298503-l60cdllh 168 4 connects connect VBZ cord-298503-l60cdllh 168 5 the the DT cord-298503-l60cdllh 168 6 IC IC NNP cord-298503-l60cdllh 168 7 with with IN cord-298503-l60cdllh 168 8 the the DT cord-298503-l60cdllh 168 9 leading leading JJ cord-298503-l60cdllh 168 10 edge edge NN cord-298503-l60cdllh 168 11 of of IN cord-298503-l60cdllh 168 12 fibroblasts fibroblast NNS cord-298503-l60cdllh 168 13 ( ( -LRB- cord-298503-l60cdllh 168 14 Figure figure NN cord-298503-l60cdllh 168 15 6 6 CD cord-298503-l60cdllh 168 16 ) ) -RRB- cord-298503-l60cdllh 168 17 . . . cord-298503-l60cdllh 169 1 Live live JJ cord-298503-l60cdllh 169 2 imaging imaging NN cord-298503-l60cdllh 169 3 of of IN cord-298503-l60cdllh 169 4 various various JJ cord-298503-l60cdllh 169 5 fluorescent fluorescent NN cord-298503-l60cdllh 169 6 IC IC NNP cord-298503-l60cdllh 169 7 markers marker NNS cord-298503-l60cdllh 169 8 indicates indicate VBZ cord-298503-l60cdllh 169 9 that that IN cord-298503-l60cdllh 169 10 the the DT cord-298503-l60cdllh 169 11 tubules tubule NNS cord-298503-l60cdllh 169 12 are be VBP cord-298503-l60cdllh 169 13 highly highly RB cord-298503-l60cdllh 169 14 dynamic dynamic JJ cord-298503-l60cdllh 169 15 , , , cord-298503-l60cdllh 169 16 while while IN cord-298503-l60cdllh 169 17 the the DT cord-298503-l60cdllh 169 18 globular globular JJ cord-298503-l60cdllh 169 19 domains domain NNS cord-298503-l60cdllh 169 20 are be VBP cord-298503-l60cdllh 169 21 typically typically RB cord-298503-l60cdllh 169 22 more more RBR cord-298503-l60cdllh 169 23 stationary stationary JJ cord-298503-l60cdllh 169 24 . . . cord-298503-l60cdllh 170 1 Due due IN cord-298503-l60cdllh 170 2 to to IN cord-298503-l60cdllh 170 3 their -PRON- PRP$ cord-298503-l60cdllh 170 4 differential differential JJ cord-298503-l60cdllh 170 5 localization localization NN cord-298503-l60cdllh 170 6 within within IN cord-298503-l60cdllh 170 7 these these DT cord-298503-l60cdllh 170 8 domains domain NNS cord-298503-l60cdllh 170 9 , , , cord-298503-l60cdllh 170 10 the the DT cord-298503-l60cdllh 170 11 constructs construct NNS cord-298503-l60cdllh 170 12 highlight highlight VBP cord-298503-l60cdllh 170 13 different different JJ cord-298503-l60cdllh 170 14 aspects aspect NNS cord-298503-l60cdllh 170 15 of of IN cord-298503-l60cdllh 170 16 IC IC NNP cord-298503-l60cdllh 170 17 dynamics dynamic NNS cord-298503-l60cdllh 170 18 ( ( -LRB- cord-298503-l60cdllh 170 19 see see VB cord-298503-l60cdllh 170 20 below below RB cord-298503-l60cdllh 170 21 ) ) -RRB- cord-298503-l60cdllh 170 22 . . . cord-298503-l60cdllh 171 1 Long long JJ cord-298503-l60cdllh 171 2 distance distance NN cord-298503-l60cdllh 171 3 ER er NN cord-298503-l60cdllh 171 4 - - HYPH cord-298503-l60cdllh 171 5 to to IN cord-298503-l60cdllh 171 6 - - HYPH cord-298503-l60cdllh 171 7 Golgi golgi NN cord-298503-l60cdllh 171 8 transport transport NN cord-298503-l60cdllh 171 9 involves involve VBZ cord-298503-l60cdllh 171 10 the the DT cord-298503-l60cdllh 171 11 movement movement NN cord-298503-l60cdllh 171 12 of of IN cord-298503-l60cdllh 171 13 IC IC NNP cord-298503-l60cdllh 171 14 elements element NNS cord-298503-l60cdllh 171 15 from from IN cord-298503-l60cdllh 171 16 the the DT cord-298503-l60cdllh 171 17 cell cell NN cord-298503-l60cdllh 171 18 periphery periphery NN cord-298503-l60cdllh 171 19 to to IN cord-298503-l60cdllh 171 20 the the DT cord-298503-l60cdllh 171 21 central central JJ cord-298503-l60cdllh 171 22 cis cis NNP cord-298503-l60cdllh 171 23 - - HYPH cord-298503-l60cdllh 171 24 Golgi Golgi NNP cord-298503-l60cdllh 171 25 region region NN cord-298503-l60cdllh 171 26 , , , cord-298503-l60cdllh 171 27 resulting result VBG cord-298503-l60cdllh 171 28 in in IN cord-298503-l60cdllh 171 29 the the DT cord-298503-l60cdllh 171 30 division division NN cord-298503-l60cdllh 171 31 of of IN cord-298503-l60cdllh 171 32 the the DT cord-298503-l60cdllh 171 33 IC IC NNP cord-298503-l60cdllh 171 34 into into IN cord-298503-l60cdllh 171 35 spatially spatially RB cord-298503-l60cdllh 171 36 distinct distinct JJ cord-298503-l60cdllh 171 37 early early JJ cord-298503-l60cdllh 171 38 ( ( -LRB- cord-298503-l60cdllh 171 39 ERESadjacent eresadjacent NN cord-298503-l60cdllh 171 40 ) ) -RRB- cord-298503-l60cdllh 171 41 and and CC cord-298503-l60cdllh 171 42 late late JJ cord-298503-l60cdllh 171 43 ( ( -LRB- cord-298503-l60cdllh 171 44 cis cis NNP cord-298503-l60cdllh 171 45 - - HYPH cord-298503-l60cdllh 171 46 Golgi Golgi NNP cord-298503-l60cdllh 171 47 - - HYPH cord-298503-l60cdllh 171 48 adjacent adjacent JJ cord-298503-l60cdllh 171 49 ) ) -RRB- cord-298503-l60cdllh 171 50 domains domain NNS cord-298503-l60cdllh 171 51 ( ( -LRB- cord-298503-l60cdllh 171 52 Saraste Saraste NNP cord-298503-l60cdllh 171 53 and and CC cord-298503-l60cdllh 171 54 Svensson Svensson NNP cord-298503-l60cdllh 171 55 , , , cord-298503-l60cdllh 171 56 1991 1991 CD cord-298503-l60cdllh 171 57 ; ; : cord-298503-l60cdllh 171 58 Presley Presley NNP cord-298503-l60cdllh 171 59 et et NNP cord-298503-l60cdllh 171 60 al al NNP cord-298503-l60cdllh 171 61 . . NNP cord-298503-l60cdllh 171 62 , , , cord-298503-l60cdllh 171 63 1997 1997 CD cord-298503-l60cdllh 171 64 ; ; . cord-298503-l60cdllh 172 1 Scales Scales NNP cord-298503-l60cdllh 172 2 et et NNP cord-298503-l60cdllh 172 3 al al NNP cord-298503-l60cdllh 172 4 . . NNP cord-298503-l60cdllh 172 5 , , , cord-298503-l60cdllh 172 6 1997 1997 CD cord-298503-l60cdllh 172 7 ; ; : cord-298503-l60cdllh 172 8 Marra Marra NNP cord-298503-l60cdllh 172 9 et et NNP cord-298503-l60cdllh 172 10 al al NNP cord-298503-l60cdllh 172 11 . . NNP cord-298503-l60cdllh 172 12 , , , cord-298503-l60cdllh 172 13 2001 2001 CD cord-298503-l60cdllh 172 14 ) ) -RRB- cord-298503-l60cdllh 172 15 . . . cord-298503-l60cdllh 173 1 Two two CD cord-298503-l60cdllh 173 2 types type NNS cord-298503-l60cdllh 173 3 of of IN cord-298503-l60cdllh 173 4 anterogradely anterogradely RB cord-298503-l60cdllh 173 5 moving move VBG cord-298503-l60cdllh 173 6 IC IC NNP cord-298503-l60cdllh 173 7 elements element NNS cord-298503-l60cdllh 173 8 can can MD cord-298503-l60cdllh 173 9 be be VB cord-298503-l60cdllh 173 10 resolved resolve VBN cord-298503-l60cdllh 173 11 by by IN cord-298503-l60cdllh 173 12 LM LM NNP cord-298503-l60cdllh 173 13 , , , cord-298503-l60cdllh 173 14 narrow narrow JJ cord-298503-l60cdllh 173 15 tubules tubule NNS cord-298503-l60cdllh 173 16 and and CC cord-298503-l60cdllh 173 17 large large JJ cord-298503-l60cdllh 173 18 pleiomorphic pleiomorphic JJ cord-298503-l60cdllh 173 19 structures structure NNS cord-298503-l60cdllh 173 20 . . . cord-298503-l60cdllh 174 1 Some some DT cord-298503-l60cdllh 174 2 of of IN cord-298503-l60cdllh 174 3 the the DT cord-298503-l60cdllh 174 4 latter latter JJ cord-298503-l60cdllh 174 5 appear appear VBP cord-298503-l60cdllh 174 6 to to TO cord-298503-l60cdllh 174 7 represent represent VB cord-298503-l60cdllh 174 8 saccular saccular JJ cord-298503-l60cdllh 174 9 elements element NNS cord-298503-l60cdllh 174 10 that that WDT cord-298503-l60cdllh 174 11 transform transform VBP cord-298503-l60cdllh 174 12 into into IN cord-298503-l60cdllh 174 13 elongated elongated JJ cord-298503-l60cdllh 174 14 structures structure NNS cord-298503-l60cdllh 174 15 ( ( -LRB- cord-298503-l60cdllh 174 16 ' ' `` cord-298503-l60cdllh 174 17 thick thick JJ cord-298503-l60cdllh 174 18 tubules tubule NNS cord-298503-l60cdllh 174 19 ' ' '' cord-298503-l60cdllh 174 20 ) ) -RRB- cord-298503-l60cdllh 175 1 ( ( -LRB- cord-298503-l60cdllh 175 2 Presley Presley NNP cord-298503-l60cdllh 175 3 et et NNP cord-298503-l60cdllh 175 4 al al NNP cord-298503-l60cdllh 175 5 . . NNP cord-298503-l60cdllh 175 6 , , , cord-298503-l60cdllh 175 7 2002 2002 CD cord-298503-l60cdllh 175 8 ; ; : cord-298503-l60cdllh 175 9 Marie Marie NNP cord-298503-l60cdllh 175 10 et et NNP cord-298503-l60cdllh 175 11 al al NNP cord-298503-l60cdllh 175 12 . . NNP cord-298503-l60cdllh 175 13 , , , cord-298503-l60cdllh 175 14 2009 2009 CD cord-298503-l60cdllh 175 15 ) ) -RRB- cord-298503-l60cdllh 175 16 . . . cord-298503-l60cdllh 176 1 In in IN cord-298503-l60cdllh 176 2 addition addition NN cord-298503-l60cdllh 176 3 , , , cord-298503-l60cdllh 176 4 narrow narrow JJ cord-298503-l60cdllh 176 5 tubules tubule NNS cord-298503-l60cdllh 176 6 establish establish VB cord-298503-l60cdllh 176 7 dynamic dynamic JJ cord-298503-l60cdllh 176 8 connections connection NNS cord-298503-l60cdllh 176 9 between between IN cord-298503-l60cdllh 176 10 the the DT cord-298503-l60cdllh 176 11 globular globular JJ cord-298503-l60cdllh 176 12 IC IC NNP cord-298503-l60cdllh 176 13 domains domain NNS cord-298503-l60cdllh 176 14 ( ( -LRB- cord-298503-l60cdllh 176 15 Ben Ben NNP cord-298503-l60cdllh 176 16 - - HYPH cord-298503-l60cdllh 176 17 Tekaya Tekaya NNP cord-298503-l60cdllh 176 18 et et NNP cord-298503-l60cdllh 176 19 al al NNP cord-298503-l60cdllh 176 20 . . NNP cord-298503-l60cdllh 176 21 , , , cord-298503-l60cdllh 176 22 2005 2005 CD cord-298503-l60cdllh 176 23 ; ; : cord-298503-l60cdllh 176 24 Sannerud Sannerud NNP cord-298503-l60cdllh 176 25 et et NNP cord-298503-l60cdllh 176 26 al al NNP cord-298503-l60cdllh 176 27 . . NNP cord-298503-l60cdllh 176 28 , , , cord-298503-l60cdllh 176 29 2006 2006 CD cord-298503-l60cdllh 176 30 ) ) -RRB- cord-298503-l60cdllh 176 31 . . . cord-298503-l60cdllh 177 1 The the DT cord-298503-l60cdllh 177 2 long long JJ cord-298503-l60cdllh 177 3 distance distance NN cord-298503-l60cdllh 177 4 movements movement NNS cord-298503-l60cdllh 177 5 of of IN cord-298503-l60cdllh 177 6 the the DT cord-298503-l60cdllh 177 7 IC IC NNP cord-298503-l60cdllh 177 8 elements element NNS cord-298503-l60cdllh 177 9 depend depend VBP cord-298503-l60cdllh 177 10 on on IN cord-298503-l60cdllh 177 11 MTs MTs NNP cord-298503-l60cdllh 177 12 ( ( -LRB- cord-298503-l60cdllh 177 13 Murshid Murshid NNP cord-298503-l60cdllh 177 14 and and CC cord-298503-l60cdllh 177 15 Presley Presley NNP cord-298503-l60cdllh 177 16 , , , cord-298503-l60cdllh 177 17 2004 2004 CD cord-298503-l60cdllh 177 18 ; ; : cord-298503-l60cdllh 177 19 Palmer Palmer NNP cord-298503-l60cdllh 177 20 et et NNP cord-298503-l60cdllh 177 21 al al NNP cord-298503-l60cdllh 177 22 . . NNP cord-298503-l60cdllh 177 23 , , , cord-298503-l60cdllh 177 24 2005 2005 CD cord-298503-l60cdllh 177 25 ( ( -LRB- cord-298503-l60cdllh 177 26 b b NN cord-298503-l60cdllh 177 27 ) ) -RRB- cord-298503-l60cdllh 177 28 and and CC cord-298503-l60cdllh 177 29 6 6 CD cord-298503-l60cdllh 177 30 ) ) -RRB- cord-298503-l60cdllh 177 31 . . . cord-298503-l60cdllh 178 1 The the DT cord-298503-l60cdllh 178 2 plus plus NN cord-298503-l60cdllh 178 3 - - HYPH cord-298503-l60cdllh 178 4 and and CC cord-298503-l60cdllh 178 5 minus minus JJ cord-298503-l60cdllh 178 6 - - HYPH cord-298503-l60cdllh 178 7 end end NN cord-298503-l60cdllh 178 8 directed direct VBN cord-298503-l60cdllh 178 9 motor motor NN cord-298503-l60cdllh 178 10 proteins protein NNS cord-298503-l60cdllh 178 11 kinesin kinesin NNS cord-298503-l60cdllh 178 12 and and CC cord-298503-l60cdllh 178 13 dynein dynein NN cord-298503-l60cdllh 178 14 associate associate VBP cord-298503-l60cdllh 178 15 with with IN cord-298503-l60cdllh 178 16 the the DT cord-298503-l60cdllh 178 17 IC IC NNP cord-298503-l60cdllh 178 18 elements element NNS cord-298503-l60cdllh 178 19 ( ( -LRB- cord-298503-l60cdllh 178 20 Lippincott Lippincott NNP cord-298503-l60cdllh 178 21 - - HYPH cord-298503-l60cdllh 178 22 Schwartz Schwartz NNP cord-298503-l60cdllh 178 23 et et NNP cord-298503-l60cdllh 178 24 al al NNP cord-298503-l60cdllh 178 25 . . NNP cord-298503-l60cdllh 178 26 , , , cord-298503-l60cdllh 178 27 1995 1995 CD cord-298503-l60cdllh 178 28 ; ; : cord-298503-l60cdllh 178 29 Roghi Roghi NNP cord-298503-l60cdllh 178 30 and and CC cord-298503-l60cdllh 178 31 Allan Allan NNP cord-298503-l60cdllh 178 32 , , , cord-298503-l60cdllh 178 33 1999 1999 CD cord-298503-l60cdllh 178 34 ; ; : cord-298503-l60cdllh 178 35 Stauber Stauber NNP cord-298503-l60cdllh 178 36 et et NNP cord-298503-l60cdllh 178 37 al al NNP cord-298503-l60cdllh 178 38 . . NNP cord-298503-l60cdllh 178 39 , , , cord-298503-l60cdllh 178 40 2006 2006 CD cord-298503-l60cdllh 178 41 ) ) -RRB- cord-298503-l60cdllh 178 42 , , , cord-298503-l60cdllh 178 43 explaining explain VBG cord-298503-l60cdllh 178 44 their -PRON- PRP$ cord-298503-l60cdllh 178 45 bidirectional bidirectional JJ cord-298503-l60cdllh 178 46 movements movement NNS cord-298503-l60cdllh 178 47 even even RB cord-298503-l60cdllh 178 48 along along IN cord-298503-l60cdllh 178 49 the the DT cord-298503-l60cdllh 178 50 same same JJ cord-298503-l60cdllh 178 51 MT MT NNP cord-298503-l60cdllh 178 52 tracks track NNS cord-298503-l60cdllh 178 53 ( ( -LRB- cord-298503-l60cdllh 178 54 Sannerud Sannerud NNP cord-298503-l60cdllh 178 55 et et NNP cord-298503-l60cdllh 178 56 al al NNP cord-298503-l60cdllh 178 57 . . NNP cord-298503-l60cdllh 178 58 , , , cord-298503-l60cdllh 178 59 2006 2006 CD cord-298503-l60cdllh 178 60 ) ) -RRB- cord-298503-l60cdllh 178 61 . . . cord-298503-l60cdllh 179 1 When when WRB cord-298503-l60cdllh 179 2 the the DT cord-298503-l60cdllh 179 3 MTs MTs NNP cord-298503-l60cdllh 179 4 in in IN cord-298503-l60cdllh 179 5 mammalian mammalian JJ cord-298503-l60cdllh 179 6 cells cell NNS cord-298503-l60cdllh 179 7 are be VBP cord-298503-l60cdllh 179 8 depolymerized depolymerize VBN cord-298503-l60cdllh 179 9 by by IN cord-298503-l60cdllh 179 10 nocodazole nocodazole NNP cord-298503-l60cdllh 179 11 the the DT cord-298503-l60cdllh 179 12 IC IC NNP cord-298503-l60cdllh 179 13 elements element NNS cord-298503-l60cdllh 179 14 become become VBP cord-298503-l60cdllh 179 15 immobile immobile JJ cord-298503-l60cdllh 179 16 and and CC cord-298503-l60cdllh 179 17 accumulate accumulate VBP cord-298503-l60cdllh 179 18 close close RB cord-298503-l60cdllh 179 19 to to IN cord-298503-l60cdllh 179 20 ERES ERES NNP cord-298503-l60cdllh 179 21 ( ( -LRB- cord-298503-l60cdllh 179 22 Saraste Saraste NNP cord-298503-l60cdllh 179 23 and and CC cord-298503-l60cdllh 179 24 Svensson Svensson NNP cord-298503-l60cdllh 179 25 , , , cord-298503-l60cdllh 179 26 1991 1991 CD cord-298503-l60cdllh 179 27 ; ; : cord-298503-l60cdllh 179 28 Hammond Hammond NNP cord-298503-l60cdllh 179 29 and and CC cord-298503-l60cdllh 179 30 Glick Glick NNP cord-298503-l60cdllh 179 31 , , , cord-298503-l60cdllh 179 32 2000 2000 CD cord-298503-l60cdllh 179 33 ; ; : cord-298503-l60cdllh 179 34 Ben Ben NNP cord-298503-l60cdllh 179 35 - - HYPH cord-298503-l60cdllh 179 36 Tekaya Tekaya NNP cord-298503-l60cdllh 179 37 et et NNP cord-298503-l60cdllh 179 38 al al NNP cord-298503-l60cdllh 179 39 . . . cord-298503-l60cdllh 180 1 , , , cord-298503-l60cdllh 180 2 2005 2005 CD cord-298503-l60cdllh 180 3 ; ; : cord-298503-l60cdllh 180 4 Sannerud Sannerud NNP cord-298503-l60cdllh 180 5 et et NNP cord-298503-l60cdllh 180 6 al al NNP cord-298503-l60cdllh 180 7 . . NNP cord-298503-l60cdllh 180 8 , , , cord-298503-l60cdllh 180 9 2006 2006 CD cord-298503-l60cdllh 180 10 ) ) -RRB- cord-298503-l60cdllh 180 11 . . . cord-298503-l60cdllh 181 1 Although although IN cord-298503-l60cdllh 181 2 the the DT cord-298503-l60cdllh 181 3 central central JJ cord-298503-l60cdllh 181 4 Golgi Golgi NNP cord-298503-l60cdllh 181 5 ribbon ribbon NN cord-298503-l60cdllh 181 6 breaks break VBZ cord-298503-l60cdllh 181 7 down down RP cord-298503-l60cdllh 181 8 , , , cord-298503-l60cdllh 181 9 the the DT cord-298503-l60cdllh 181 10 formation formation NN cord-298503-l60cdllh 181 11 of of IN cord-298503-l60cdllh 181 12 Golgi Golgi NNP cord-298503-l60cdllh 181 13 ministacks ministack NNS cord-298503-l60cdllh 181 14 in in IN cord-298503-l60cdllh 181 15 the the DT cord-298503-l60cdllh 181 16 vicinity vicinity NN cord-298503-l60cdllh 181 17 of of IN cord-298503-l60cdllh 181 18 ERES ERES NNP cord-298503-l60cdllh 181 19 re re NN cord-298503-l60cdllh 181 20 - - VBZ cord-298503-l60cdllh 181 21 establishes establish VBZ cord-298503-l60cdllh 181 22 ER ER NNP cord-298503-l60cdllh 181 23 - - HYPH cord-298503-l60cdllh 181 24 Golgi Golgi NNP cord-298503-l60cdllh 181 25 communication communication NN cord-298503-l60cdllh 181 26 as as IN cord-298503-l60cdllh 181 27 a a DT cord-298503-l60cdllh 181 28 short short JJ cord-298503-l60cdllh 181 29 range range NN cord-298503-l60cdllh 181 30 process process NN cord-298503-l60cdllh 181 31 ( ( -LRB- cord-298503-l60cdllh 181 32 as as IN cord-298503-l60cdllh 181 33 in in IN cord-298503-l60cdllh 181 34 plants plant NNS cord-298503-l60cdllh 181 35 ) ) -RRB- cord-298503-l60cdllh 181 36 , , , cord-298503-l60cdllh 181 37 explaining explain VBG cord-298503-l60cdllh 181 38 the the DT cord-298503-l60cdllh 181 39 ongoing ongoing JJ cord-298503-l60cdllh 181 40 Golgi Golgi NNP cord-298503-l60cdllh 181 41 modification modification NN cord-298503-l60cdllh 181 42 and and CC cord-298503-l60cdllh 181 43 secretion secretion NN cord-298503-l60cdllh 181 44 of of IN cord-298503-l60cdllh 181 45 proteins protein NNS cord-298503-l60cdllh 181 46 ( ( -LRB- cord-298503-l60cdllh 181 47 Saraste Saraste NNP cord-298503-l60cdllh 181 48 and and CC cord-298503-l60cdllh 181 49 Svensson Svensson NNP cord-298503-l60cdllh 181 50 , , , cord-298503-l60cdllh 181 51 1991 1991 CD cord-298503-l60cdllh 181 52 ; ; : cord-298503-l60cdllh 181 53 Cole Cole NNP cord-298503-l60cdllh 181 54 et et NNP cord-298503-l60cdllh 181 55 al al NNP cord-298503-l60cdllh 181 56 . . . cord-298503-l60cdllh 182 1 , , , cord-298503-l60cdllh 182 2 1996 1996 CD cord-298503-l60cdllh 182 3 ; ; : cord-298503-l60cdllh 182 4 Storrie Storrie NNP cord-298503-l60cdllh 182 5 et et NNP cord-298503-l60cdllh 182 6 al al NNP cord-298503-l60cdllh 182 7 . . NNP cord-298503-l60cdllh 182 8 , , , cord-298503-l60cdllh 182 9 1998 1998 CD cord-298503-l60cdllh 182 10 ) ) -RRB- cord-298503-l60cdllh 182 11 . . . cord-298503-l60cdllh 183 1 The the DT cord-298503-l60cdllh 183 2 Rho Rho NNP cord-298503-l60cdllh 183 3 family family NN cord-298503-l60cdllh 184 1 GTPase GTPase NNP cord-298503-l60cdllh 184 2 cdc42 cdc42 NNP cord-298503-l60cdllh 184 3 , , , cord-298503-l60cdllh 184 4 which which WDT cord-298503-l60cdllh 184 5 regulates regulate VBZ cord-298503-l60cdllh 184 6 actin actin NN cord-298503-l60cdllh 184 7 dynamics dynamic NNS cord-298503-l60cdllh 184 8 , , , cord-298503-l60cdllh 184 9 interacts interact VBZ cord-298503-l60cdllh 184 10 with with IN cord-298503-l60cdllh 184 11 COPI COPI NNP cord-298503-l60cdllh 184 12 coats coat NNS cord-298503-l60cdllh 184 13 and and CC cord-298503-l60cdllh 184 14 affects affect VBZ cord-298503-l60cdllh 184 15 dynein dynein JJ cord-298503-l60cdllh 184 16 function function NN cord-298503-l60cdllh 184 17 , , , cord-298503-l60cdllh 184 18 suggesting suggest VBG cord-298503-l60cdllh 184 19 functional functional JJ cord-298503-l60cdllh 184 20 coupling coupling NN cord-298503-l60cdllh 184 21 between between IN cord-298503-l60cdllh 184 22 the the DT cord-298503-l60cdllh 184 23 actin actin NN cord-298503-l60cdllh 184 24 filament filament NN cord-298503-l60cdllh 184 25 system system NN cord-298503-l60cdllh 184 26 and and CC cord-298503-l60cdllh 184 27 MT MT NNP cord-298503-l60cdllh 184 28 - - HYPH cord-298503-l60cdllh 184 29 dependent dependent JJ cord-298503-l60cdllh 184 30 motility motility NN cord-298503-l60cdllh 184 31 of of IN cord-298503-l60cdllh 184 32 IC IC NNP cord-298503-l60cdllh 184 33 / / SYM cord-298503-l60cdllh 184 34 cis cis NNP cord-298503-l60cdllh 184 35 - - HYPH cord-298503-l60cdllh 184 36 Golgi Golgi NNP cord-298503-l60cdllh 184 37 carriers carrier NNS cord-298503-l60cdllh 184 38 ( ( -LRB- cord-298503-l60cdllh 184 39 Luna Luna NNP cord-298503-l60cdllh 184 40 et et FW cord-298503-l60cdllh 184 41 al al NNP cord-298503-l60cdllh 184 42 . . . cord-298503-l60cdllh 185 1 , , , cord-298503-l60cdllh 185 2 2002 2002 CD cord-298503-l60cdllh 185 3 ; ; : cord-298503-l60cdllh 185 4 Chen Chen NNP cord-298503-l60cdllh 185 5 et et NNP cord-298503-l60cdllh 185 6 al al NNP cord-298503-l60cdllh 185 7 . . NNP cord-298503-l60cdllh 185 8 , , , cord-298503-l60cdllh 185 9 2005 2005 CD cord-298503-l60cdllh 185 10 ) ) -RRB- cord-298503-l60cdllh 185 11 . . . cord-298503-l60cdllh 186 1 Similarly similarly RB cord-298503-l60cdllh 186 2 , , , cord-298503-l60cdllh 186 3 WHAMM WHAMM NNP cord-298503-l60cdllh 186 4 , , , cord-298503-l60cdllh 186 5 which which WDT cord-298503-l60cdllh 186 6 promotes promote VBZ cord-298503-l60cdllh 186 7 actin actin NN cord-298503-l60cdllh 186 8 nucleation nucleation NN cord-298503-l60cdllh 186 9 and and CC cord-298503-l60cdllh 186 10 interacts interact VBZ cord-298503-l60cdllh 186 11 with with IN cord-298503-l60cdllh 186 12 MTs MTs NNP cord-298503-l60cdllh 186 13 , , , cord-298503-l60cdllh 186 14 has have VBZ cord-298503-l60cdllh 186 15 been be VBN cord-298503-l60cdllh 186 16 localized localize VBN cord-298503-l60cdllh 186 17 to to IN cord-298503-l60cdllh 186 18 the the DT cord-298503-l60cdllh 186 19 IC IC NNP cord-298503-l60cdllh 186 20 and and CC cord-298503-l60cdllh 186 21 implicated implicate VBN cord-298503-l60cdllh 186 22 in in IN cord-298503-l60cdllh 186 23 the the DT cord-298503-l60cdllh 186 24 formation formation NN cord-298503-l60cdllh 186 25 and and CC cord-298503-l60cdllh 186 26 transport transport NN cord-298503-l60cdllh 186 27 of of IN cord-298503-l60cdllh 186 28 pre pre JJ cord-298503-l60cdllh 186 29 - - JJ cord-298503-l60cdllh 186 30 Golgi golgi JJ cord-298503-l60cdllh 186 31 tubules tubule NNS cord-298503-l60cdllh 186 32 ( ( -LRB- cord-298503-l60cdllh 186 33 Campellone Campellone NNP cord-298503-l60cdllh 186 34 et et NNP cord-298503-l60cdllh 186 35 al al NNP cord-298503-l60cdllh 186 36 . . NNP cord-298503-l60cdllh 186 37 , , , cord-298503-l60cdllh 186 38 2008 2008 CD cord-298503-l60cdllh 186 39 ) ) -RRB- cord-298503-l60cdllh 186 40 . . . cord-298503-l60cdllh 187 1 Based base VBN cord-298503-l60cdllh 187 2 on on IN cord-298503-l60cdllh 187 3 imaging imaging NN cord-298503-l60cdllh 187 4 of of IN cord-298503-l60cdllh 187 5 fluorescent fluorescent JJ cord-298503-l60cdllh 187 6 cargo cargo NN cord-298503-l60cdllh 187 7 , , , cord-298503-l60cdllh 187 8 such such JJ cord-298503-l60cdllh 187 9 as as IN cord-298503-l60cdllh 187 10 the the DT cord-298503-l60cdllh 187 11 VSV VSV NNP cord-298503-l60cdllh 187 12 G G NNP cord-298503-l60cdllh 187 13 - - HYPH cord-298503-l60cdllh 187 14 protein protein NN cord-298503-l60cdllh 187 15 and and CC cord-298503-l60cdllh 187 16 procollagen procollagen NNP cord-298503-l60cdllh 187 17 , , , cord-298503-l60cdllh 187 18 in in IN cord-298503-l60cdllh 187 19 living living NN cord-298503-l60cdllh 187 20 cells cell NNS cord-298503-l60cdllh 187 21 ( ( -LRB- cord-298503-l60cdllh 187 22 Presley Presley NNP cord-298503-l60cdllh 187 23 et et NNP cord-298503-l60cdllh 187 24 al al NNP cord-298503-l60cdllh 187 25 . . NNP cord-298503-l60cdllh 187 26 , , , cord-298503-l60cdllh 187 27 1997 1997 CD cord-298503-l60cdllh 187 28 ; ; : cord-298503-l60cdllh 187 29 Scales Scales NNP cord-298503-l60cdllh 187 30 et et NNP cord-298503-l60cdllh 187 31 al al NNP cord-298503-l60cdllh 187 32 . . NNP cord-298503-l60cdllh 187 33 , , , cord-298503-l60cdllh 187 34 1997 1997 CD cord-298503-l60cdllh 187 35 ; ; : cord-298503-l60cdllh 187 36 Stephens Stephens NNP cord-298503-l60cdllh 187 37 and and CC cord-298503-l60cdllh 187 38 Pepperkok Pepperkok NNP cord-298503-l60cdllh 187 39 , , , cord-298503-l60cdllh 187 40 2002 2002 CD cord-298503-l60cdllh 187 41 ) ) -RRB- cord-298503-l60cdllh 187 42 , , , cord-298503-l60cdllh 187 43 it -PRON- PRP cord-298503-l60cdllh 187 44 has have VBZ cord-298503-l60cdllh 187 45 been be VBN cord-298503-l60cdllh 187 46 proposed propose VBN cord-298503-l60cdllh 187 47 that that IN cord-298503-l60cdllh 187 48 the the DT cord-298503-l60cdllh 187 49 IC IC NNP cord-298503-l60cdllh 187 50 represents represent VBZ cord-298503-l60cdllh 187 51 a a DT cord-298503-l60cdllh 187 52 collection collection NN cord-298503-l60cdllh 187 53 of of IN cord-298503-l60cdllh 187 54 large large JJ cord-298503-l60cdllh 187 55 , , , cord-298503-l60cdllh 187 56 pleiomorphic pleiomorphic JJ cord-298503-l60cdllh 187 57 transport transport NN cord-298503-l60cdllh 187 58 complexes complex NNS cord-298503-l60cdllh 187 59 ( ( -LRB- cord-298503-l60cdllh 187 60 TCs TCs NNP cord-298503-l60cdllh 187 61 ) ) -RRB- cord-298503-l60cdllh 187 62 ( ( -LRB- cord-298503-l60cdllh 187 63 Bannykh Bannykh NNP cord-298503-l60cdllh 187 64 and and CC cord-298503-l60cdllh 187 65 Balch Balch NNP cord-298503-l60cdllh 187 66 , , , cord-298503-l60cdllh 187 67 1997 1997 CD cord-298503-l60cdllh 187 68 ; ; : cord-298503-l60cdllh 187 69 Stephens Stephens NNP cord-298503-l60cdllh 187 70 and and CC cord-298503-l60cdllh 187 71 Pepperkok Pepperkok NNP cord-298503-l60cdllh 187 72 , , , cord-298503-l60cdllh 187 73 2001 2001 CD cord-298503-l60cdllh 187 74 ) ) -RRB- cord-298503-l60cdllh 187 75 , , , cord-298503-l60cdllh 187 76 which which WDT cord-298503-l60cdllh 187 77 form form VBP cord-298503-l60cdllh 187 78 via via IN cord-298503-l60cdllh 187 79 homotypic homotypic JJ cord-298503-l60cdllh 187 80 fusion fusion NN cord-298503-l60cdllh 187 81 of of IN cord-298503-l60cdllh 187 82 COPII COPII NNP cord-298503-l60cdllh 187 83 vesicles vesicle NNS cord-298503-l60cdllh 187 84 , , , cord-298503-l60cdllh 187 85 or or CC cord-298503-l60cdllh 187 86 protrude protrude VBP cord-298503-l60cdllh 187 87 directly directly RB cord-298503-l60cdllh 187 88 from from IN cord-298503-l60cdllh 187 89 the the DT cord-298503-l60cdllh 187 90 ER er NN cord-298503-l60cdllh 188 1 ( ( -LRB- cord-298503-l60cdllh 188 2 Mironov Mironov NNP cord-298503-l60cdllh 188 3 et et FW cord-298503-l60cdllh 188 4 al al NNP cord-298503-l60cdllh 188 5 . . NNP cord-298503-l60cdllh 188 6 , , , cord-298503-l60cdllh 188 7 2003 2003 CD cord-298503-l60cdllh 188 8 ; ; : cord-298503-l60cdllh 189 1 Xu Xu NNP cord-298503-l60cdllh 189 2 and and CC cord-298503-l60cdllh 189 3 Hay Hay NNP cord-298503-l60cdllh 189 4 , , , cord-298503-l60cdllh 189 5 2004 2004 CD cord-298503-l60cdllh 189 6 ; ; : cord-298503-l60cdllh 189 7 Yu Yu NNP cord-298503-l60cdllh 189 8 et et NNP cord-298503-l60cdllh 189 9 al al NNP cord-298503-l60cdllh 189 10 . . NNP cord-298503-l60cdllh 189 11 , , , cord-298503-l60cdllh 189 12 2006 2006 CD cord-298503-l60cdllh 189 13 ) ) -RRB- cord-298503-l60cdllh 189 14 . . . cord-298503-l60cdllh 190 1 Thereafter thereafter RB cord-298503-l60cdllh 190 2 , , , cord-298503-l60cdllh 190 3 they -PRON- PRP cord-298503-l60cdllh 190 4 move move VBP cord-298503-l60cdllh 190 5 in in IN cord-298503-l60cdllh 190 6 a a DT cord-298503-l60cdllh 190 7 MT MT NNP cord-298503-l60cdllh 190 8 - - : cord-298503-l60cdllh 190 9 and and CC cord-298503-l60cdllh 190 10 dynein dynein NN cord-298503-l60cdllh 190 11 - - HYPH cord-298503-l60cdllh 190 12 dependent dependent JJ cord-298503-l60cdllh 190 13 ( ( -LRB- cord-298503-l60cdllh 190 14 Burkhardt Burkhardt NNP cord-298503-l60cdllh 190 15 et et NNP cord-298503-l60cdllh 190 16 al al NNP cord-298503-l60cdllh 190 17 . . NNP cord-298503-l60cdllh 190 18 , , , cord-298503-l60cdllh 190 19 1997 1997 CD cord-298503-l60cdllh 190 20 ) ) -RRB- cord-298503-l60cdllh 190 21 ' ' `` cord-298503-l60cdllh 190 22 stop stop VB cord-298503-l60cdllh 190 23 - - HYPH cord-298503-l60cdllh 190 24 and and CC cord-298503-l60cdllh 190 25 - - HYPH cord-298503-l60cdllh 190 26 go go VB cord-298503-l60cdllh 190 27 ' ' '' cord-298503-l60cdllh 190 28 fashion fashion NN cord-298503-l60cdllh 190 29 to to IN cord-298503-l60cdllh 190 30 the the DT cord-298503-l60cdllh 190 31 Golgi Golgi NNP cord-298503-l60cdllh 190 32 region region NN cord-298503-l60cdllh 190 33 , , , cord-298503-l60cdllh 190 34 where where WRB cord-298503-l60cdllh 190 35 they -PRON- PRP cord-298503-l60cdllh 190 36 either either CC cord-298503-l60cdllh 190 37 fuse fuse VBP cord-298503-l60cdllh 190 38 with with IN cord-298503-l60cdllh 190 39 or or CC cord-298503-l60cdllh 190 40 transform transform VB cord-298503-l60cdllh 190 41 into into IN cord-298503-l60cdllh 190 42 cis cis NNP cord-298503-l60cdllh 190 43 - - HYPH cord-298503-l60cdllh 190 44 Golgi Golgi NNP cord-298503-l60cdllh 190 45 cisternae cisternae NNP cord-298503-l60cdllh 190 46 ( ( -LRB- cord-298503-l60cdllh 190 47 Figure figure NN cord-298503-l60cdllh 190 48 7(a 7(a CD cord-298503-l60cdllh 190 49 ) ) -RRB- cord-298503-l60cdllh 190 50 ) ) -RRB- cord-298503-l60cdllh 190 51 . . . cord-298503-l60cdllh 191 1 In in IN cord-298503-l60cdllh 191 2 other other JJ cord-298503-l60cdllh 191 3 words word NNS cord-298503-l60cdllh 191 4 , , , cord-298503-l60cdllh 191 5 the the DT cord-298503-l60cdllh 191 6 IC IC NNP cord-298503-l60cdllh 191 7 elements element NNS cord-298503-l60cdllh 191 8 are be VBP cord-298503-l60cdllh 191 9 transient transient JJ cord-298503-l60cdllh 191 10 structures structure NNS cord-298503-l60cdllh 191 11 which which WDT cord-298503-l60cdllh 191 12 are be VBP cord-298503-l60cdllh 191 13 first first RB cord-298503-l60cdllh 191 14 formed form VBN cord-298503-l60cdllh 191 15 de de FW cord-298503-l60cdllh 191 16 novo novo NNP cord-298503-l60cdllh 191 17 at at IN cord-298503-l60cdllh 191 18 ERES ERES NNP cord-298503-l60cdllh 191 19 and and CC cord-298503-l60cdllh 191 20 then then RB cord-298503-l60cdllh 191 21 consumed consume VBN cord-298503-l60cdllh 191 22 at at IN cord-298503-l60cdllh 191 23 cis cis NNP cord-298503-l60cdllh 191 24 - - HYPH cord-298503-l60cdllh 191 25 Golgi Golgi NNP cord-298503-l60cdllh 191 26 . . . cord-298503-l60cdllh 192 1 These these DT cord-298503-l60cdllh 192 2 mobile mobile JJ cord-298503-l60cdllh 192 3 structures structure NNS cord-298503-l60cdllh 192 4 ( ( -LRB- cord-298503-l60cdllh 192 5 speed speed NN cord-298503-l60cdllh 192 6 of of IN cord-298503-l60cdllh 192 7 about about RB cord-298503-l60cdllh 192 8 1 1 CD cord-298503-l60cdllh 192 9 mm mm NNP cord-298503-l60cdllh 192 10 / / SYM cord-298503-l60cdllh 192 11 sec sec NNP cord-298503-l60cdllh 192 12 ) ) -RRB- cord-298503-l60cdllh 192 13 corresponding correspond VBG cord-298503-l60cdllh 192 14 to to IN cord-298503-l60cdllh 192 15 saccules saccule NNS cord-298503-l60cdllh 192 16 or or CC cord-298503-l60cdllh 192 17 more more RBR cord-298503-l60cdllh 192 18 complex complex JJ cord-298503-l60cdllh 192 19 , , , cord-298503-l60cdllh 192 20 pleiomorphic pleiomorphic JJ cord-298503-l60cdllh 192 21 elements element NNS cord-298503-l60cdllh 193 1 ( ( -LRB- cord-298503-l60cdllh 193 2 Mironov Mironov NNP cord-298503-l60cdllh 193 3 et et FW cord-298503-l60cdllh 193 4 al al NNP cord-298503-l60cdllh 193 5 . . NNP cord-298503-l60cdllh 193 6 , , , cord-298503-l60cdllh 193 7 2003 2003 CD cord-298503-l60cdllh 193 8 ) ) -RRB- cord-298503-l60cdllh 193 9 appear appear VBP cord-298503-l60cdllh 193 10 to to TO cord-298503-l60cdllh 193 11 consist consist VB cord-298503-l60cdllh 193 12 of of IN cord-298503-l60cdllh 193 13 subdomains subdomain NNS cord-298503-l60cdllh 193 14 enriched enrich VBN cord-298503-l60cdllh 193 15 in in IN cord-298503-l60cdllh 193 16 antero antero NNP cord-298503-l60cdllh 193 17 - - , cord-298503-l60cdllh 193 18 or or CC cord-298503-l60cdllh 193 19 retrograde retrograde JJ cord-298503-l60cdllh 193 20 cargo cargo NN cord-298503-l60cdllh 193 21 , , , cord-298503-l60cdllh 193 22 or or CC cord-298503-l60cdllh 193 23 COPI COPI NNP cord-298503-l60cdllh 193 24 ( ( -LRB- cord-298503-l60cdllh 194 1 Shima Shima NNP cord-298503-l60cdllh 194 2 et et NNP cord-298503-l60cdllh 194 3 al al NNP cord-298503-l60cdllh 194 4 . . . cord-298503-l60cdllh 195 1 , , , cord-298503-l60cdllh 195 2 1999 1999 CD cord-298503-l60cdllh 195 3 ; ; : cord-298503-l60cdllh 195 4 Stephens Stephens NNP cord-298503-l60cdllh 195 5 et et NNP cord-298503-l60cdllh 195 6 al al NNP cord-298503-l60cdllh 195 7 . . NNP cord-298503-l60cdllh 195 8 , , , cord-298503-l60cdllh 195 9 2000 2000 CD cord-298503-l60cdllh 195 10 ) ) -RRB- cord-298503-l60cdllh 195 11 . . . cord-298503-l60cdllh 196 1 They -PRON- PRP cord-298503-l60cdllh 196 2 have have VBP cord-298503-l60cdllh 196 3 also also RB cord-298503-l60cdllh 196 4 been be VBN cord-298503-l60cdllh 196 5 shown show VBN cord-298503-l60cdllh 196 6 to to TO cord-298503-l60cdllh 196 7 contain contain VB cord-298503-l60cdllh 196 8 other other JJ cord-298503-l60cdllh 196 9 machinery machinery NN cord-298503-l60cdllh 196 10 proteins protein NNS cord-298503-l60cdllh 196 11 , , , cord-298503-l60cdllh 196 12 such such JJ cord-298503-l60cdllh 196 13 as as IN cord-298503-l60cdllh 196 14 p23/24 p23/24 NNP cord-298503-l60cdllh 196 15 , , , cord-298503-l60cdllh 196 16 p58 p58 NNP cord-298503-l60cdllh 196 17 , , , cord-298503-l60cdllh 196 18 VIP36 VIP36 NNP cord-298503-l60cdllh 196 19 , , , cord-298503-l60cdllh 196 20 membrin membrin NNP cord-298503-l60cdllh 196 21 and and CC cord-298503-l60cdllh 196 22 Rab1A Rab1A NNS cord-298503-l60cdllh 197 1 ( ( -LRB- cord-298503-l60cdllh 197 2 Blum Blum NNP cord-298503-l60cdllh 197 3 et et NNP cord-298503-l60cdllh 197 4 al al NNP cord-298503-l60cdllh 197 5 . . NNP cord-298503-l60cdllh 197 6 , , , cord-298503-l60cdllh 197 7 1999 1999 CD cord-298503-l60cdllh 197 8 ; ; : cord-298503-l60cdllh 197 9 _SP cord-298503-l60cdllh 198 1 Golgi Golgi NNP cord-298503-l60cdllh 198 2 Nu Nu NNP cord-298503-l60cdllh 198 3 Figure Figure NNP cord-298503-l60cdllh 198 4 5 5 CD cord-298503-l60cdllh 198 5 Immunofluorescence Immunofluorescence NNP cord-298503-l60cdllh 198 6 LM LM NNP cord-298503-l60cdllh 198 7 localization localization NN cord-298503-l60cdllh 198 8 of of IN cord-298503-l60cdllh 198 9 Rab1 Rab1 NNP cord-298503-l60cdllh 198 10 in in IN cord-298503-l60cdllh 198 11 differentiating differentiate VBG cord-298503-l60cdllh 198 12 PC12 pc12 JJ cord-298503-l60cdllh 198 13 cells cell NNS cord-298503-l60cdllh 198 14 , , , cord-298503-l60cdllh 198 15 illustrating illustrate VBG cord-298503-l60cdllh 198 16 the the DT cord-298503-l60cdllh 198 17 interconnected interconnect VBN cord-298503-l60cdllh 198 18 globular globular JJ cord-298503-l60cdllh 198 19 ( ( -LRB- cord-298503-l60cdllh 198 20 arrowheads arrowhead NNS cord-298503-l60cdllh 198 21 ) ) -RRB- cord-298503-l60cdllh 198 22 and and CC cord-298503-l60cdllh 198 23 tubular tubular JJ cord-298503-l60cdllh 198 24 ( ( -LRB- cord-298503-l60cdllh 198 25 arrows arrow NNS cord-298503-l60cdllh 198 26 ) ) -RRB- cord-298503-l60cdllh 198 27 domains domain NNS cord-298503-l60cdllh 198 28 of of IN cord-298503-l60cdllh 198 29 the the DT cord-298503-l60cdllh 198 30 IC IC NNP cord-298503-l60cdllh 198 31 . . . cord-298503-l60cdllh 199 1 Two two CD cord-298503-l60cdllh 199 2 confocal confocal JJ cord-298503-l60cdllh 199 3 sections section NNS cord-298503-l60cdllh 199 4 of of IN cord-298503-l60cdllh 199 5 the the DT cord-298503-l60cdllh 199 6 same same JJ cord-298503-l60cdllh 199 7 cell cell NN cord-298503-l60cdllh 199 8 are be VBP cord-298503-l60cdllh 199 9 shown show VBN cord-298503-l60cdllh 199 10 . . . cord-298503-l60cdllh 200 1 The the DT cord-298503-l60cdllh 200 2 IC IC NNP cord-298503-l60cdllh 200 3 has have VBZ cord-298503-l60cdllh 200 4 expanded expand VBN cord-298503-l60cdllh 200 5 in in IN cord-298503-l60cdllh 200 6 response response NN cord-298503-l60cdllh 200 7 to to IN cord-298503-l60cdllh 200 8 a a DT cord-298503-l60cdllh 200 9 24 24 CD cord-298503-l60cdllh 200 10 h h NN cord-298503-l60cdllh 200 11 treatment treatment NN cord-298503-l60cdllh 200 12 with with IN cord-298503-l60cdllh 200 13 the the DT cord-298503-l60cdllh 200 14 nerve nerve NN cord-298503-l60cdllh 200 15 growth growth NN cord-298503-l60cdllh 200 16 factor factor NN cord-298503-l60cdllh 200 17 ( ( -LRB- cord-298503-l60cdllh 200 18 NGF NGF NNP cord-298503-l60cdllh 200 19 ) ) -RRB- cord-298503-l60cdllh 200 20 and and CC cord-298503-l60cdllh 200 21 the the DT cord-298503-l60cdllh 200 22 tubules tubule NNS cord-298503-l60cdllh 200 23 are be VBP cord-298503-l60cdllh 200 24 found find VBN cord-298503-l60cdllh 200 25 both both CC cord-298503-l60cdllh 200 26 in in IN cord-298503-l60cdllh 200 27 the the DT cord-298503-l60cdllh 200 28 cell cell NN cord-298503-l60cdllh 200 29 body body NN cord-298503-l60cdllh 200 30 and and CC cord-298503-l60cdllh 200 31 the the DT cord-298503-l60cdllh 200 32 neurite neurite NN cord-298503-l60cdllh 200 33 - - HYPH cord-298503-l60cdllh 200 34 like like JJ cord-298503-l60cdllh 200 35 extensions extension NNS cord-298503-l60cdllh 200 36 ( ( -LRB- cord-298503-l60cdllh 200 37 right right JJ cord-298503-l60cdllh 200 38 panel panel NN cord-298503-l60cdllh 200 39 ) ) -RRB- cord-298503-l60cdllh 200 40 . . . cord-298503-l60cdllh 201 1 Nu Nu NNP cord-298503-l60cdllh 201 2 , , , cord-298503-l60cdllh 201 3 nucleus nucleus NN cord-298503-l60cdllh 201 4 ; ; : cord-298503-l60cdllh 201 5 Golgi Golgi NNP cord-298503-l60cdllh 201 6 , , , cord-298503-l60cdllh 201 7 perinuclear perinuclear NNP cord-298503-l60cdllh 201 8 Golgi Golgi NNP cord-298503-l60cdllh 201 9 region region NN cord-298503-l60cdllh 201 10 . . . cord-298503-l60cdllh 202 1 Bar bar NN cord-298503-l60cdllh 202 2 : : : cord-298503-l60cdllh 202 3 5 5 CD cord-298503-l60cdllh 202 4 mm mm NN cord-298503-l60cdllh 202 5 . . . cord-298503-l60cdllh 203 1 Time time NN cord-298503-l60cdllh 203 2 projection projection NN cord-298503-l60cdllh 203 3 Figure figure NN cord-298503-l60cdllh 203 4 6 6 CD cord-298503-l60cdllh 203 5 Bidirectional bidirectional JJ cord-298503-l60cdllh 203 6 movements movement NNS cord-298503-l60cdllh 203 7 of of IN cord-298503-l60cdllh 203 8 GFP gfp NN cord-298503-l60cdllh 203 9 - - HYPH cord-298503-l60cdllh 203 10 Rab1A rab1a NN cord-298503-l60cdllh 203 11 - - HYPH cord-298503-l60cdllh 203 12 positive positive JJ cord-298503-l60cdllh 203 13 tubules tubule NNS cord-298503-l60cdllh 203 14 in in IN cord-298503-l60cdllh 203 15 a a DT cord-298503-l60cdllh 203 16 living live VBG cord-298503-l60cdllh 203 17 NRK NRK NNP cord-298503-l60cdllh 203 18 cell cell NN cord-298503-l60cdllh 203 19 . . . cord-298503-l60cdllh 204 1 Selected select VBN cord-298503-l60cdllh 204 2 confocal confocal JJ cord-298503-l60cdllh 204 3 images image NNS cord-298503-l60cdllh 204 4 from from IN cord-298503-l60cdllh 204 5 a a DT cord-298503-l60cdllh 204 6 movie movie NN cord-298503-l60cdllh 204 7 obtained obtain VBN cord-298503-l60cdllh 204 8 by by IN cord-298503-l60cdllh 204 9 timelapse timelapse NN cord-298503-l60cdllh 204 10 microscopy microscopy NNS cord-298503-l60cdllh 204 11 are be VBP cord-298503-l60cdllh 204 12 shown show VBN cord-298503-l60cdllh 204 13 . . . cord-298503-l60cdllh 205 1 Tubules tubule NNS cord-298503-l60cdllh 205 2 extending extend VBG cord-298503-l60cdllh 205 3 from from IN cord-298503-l60cdllh 205 4 the the DT cord-298503-l60cdllh 205 5 same same JJ cord-298503-l60cdllh 205 6 relatively relatively RB cord-298503-l60cdllh 205 7 stationary stationary JJ cord-298503-l60cdllh 205 8 globular globular JJ cord-298503-l60cdllh 205 9 IC IC NNP cord-298503-l60cdllh 205 10 element element NN cord-298503-l60cdllh 205 11 ( ( -LRB- cord-298503-l60cdllh 205 12 black black JJ cord-298503-l60cdllh 205 13 arrowhead arrowhead NNP cord-298503-l60cdllh 205 14 ) ) -RRB- cord-298503-l60cdllh 205 15 pinch pinch VB cord-298503-l60cdllh 205 16 off off RP cord-298503-l60cdllh 205 17 and and CC cord-298503-l60cdllh 205 18 move move VB cord-298503-l60cdllh 205 19 either either CC cord-298503-l60cdllh 205 20 in in IN cord-298503-l60cdllh 205 21 the the DT cord-298503-l60cdllh 205 22 direction direction NN cord-298503-l60cdllh 205 23 of of IN cord-298503-l60cdllh 205 24 the the DT cord-298503-l60cdllh 205 25 cell cell NN cord-298503-l60cdllh 205 26 's 's POS cord-298503-l60cdllh 205 27 leading leading JJ cord-298503-l60cdllh 205 28 edge edge NN cord-298503-l60cdllh 205 29 ( ( -LRB- cord-298503-l60cdllh 205 30 upper upper JJ cord-298503-l60cdllh 205 31 panels panel NNS cord-298503-l60cdllh 205 32 ; ; : cord-298503-l60cdllh 205 33 yellow yellow JJ cord-298503-l60cdllh 205 34 arrowheads arrowhead NNS cord-298503-l60cdllh 205 35 ) ) -RRB- cord-298503-l60cdllh 205 36 , , , cord-298503-l60cdllh 205 37 or or CC cord-298503-l60cdllh 205 38 toward toward IN cord-298503-l60cdllh 205 39 the the DT cord-298503-l60cdllh 205 40 Golgi Golgi NNP cord-298503-l60cdllh 205 41 indicated indicate VBN cord-298503-l60cdllh 205 42 by by IN cord-298503-l60cdllh 205 43 an an DT cord-298503-l60cdllh 205 44 asterisk asterisk NN cord-298503-l60cdllh 205 45 ( ( -LRB- cord-298503-l60cdllh 205 46 lower low JJR cord-298503-l60cdllh 205 47 panels panel NNS cord-298503-l60cdllh 205 48 ; ; : cord-298503-l60cdllh 205 49 red red JJ cord-298503-l60cdllh 205 50 arrowheads arrowhead NNS cord-298503-l60cdllh 205 51 ) ) -RRB- cord-298503-l60cdllh 205 52 . . . cord-298503-l60cdllh 206 1 The the DT cord-298503-l60cdllh 206 2 paths path NNS cord-298503-l60cdllh 206 3 taken take VBN cord-298503-l60cdllh 206 4 by by IN cord-298503-l60cdllh 206 5 the the DT cord-298503-l60cdllh 206 6 tubules tubule NNS cord-298503-l60cdllh 206 7 are be VBP cord-298503-l60cdllh 206 8 highlighted highlight VBN cord-298503-l60cdllh 206 9 in in IN cord-298503-l60cdllh 206 10 the the DT cord-298503-l60cdllh 206 11 time time NN cord-298503-l60cdllh 206 12 projection projection NN cord-298503-l60cdllh 206 13 on on IN cord-298503-l60cdllh 206 14 the the DT cord-298503-l60cdllh 206 15 right right NN cord-298503-l60cdllh 206 16 . . . cord-298503-l60cdllh 207 1 Adapted adapt VBN cord-298503-l60cdllh 207 2 from from IN cord-298503-l60cdllh 207 3 Sannerud Sannerud NNP cord-298503-l60cdllh 207 4 , , , cord-298503-l60cdllh 207 5 R. R. NNP cord-298503-l60cdllh 207 6 , , , cord-298503-l60cdllh 207 7 Marie Marie NNP cord-298503-l60cdllh 207 8 , , , cord-298503-l60cdllh 207 9 M. M. NNP cord-298503-l60cdllh 207 10 , , , cord-298503-l60cdllh 207 11 Nizak Nizak NNP cord-298503-l60cdllh 207 12 , , , cord-298503-l60cdllh 207 13 C. C. NNP cord-298503-l60cdllh 207 14 , , , cord-298503-l60cdllh 207 15 et et NNP cord-298503-l60cdllh 207 16 al al NNP cord-298503-l60cdllh 207 17 . . NNP cord-298503-l60cdllh 207 18 , , , cord-298503-l60cdllh 207 19 2006 2006 CD cord-298503-l60cdllh 208 1 Chao Chao NNP cord-298503-l60cdllh 208 2 et et NNP cord-298503-l60cdllh 208 3 al al NNP cord-298503-l60cdllh 208 4 . . NNP cord-298503-l60cdllh 208 5 , , , cord-298503-l60cdllh 208 6 1999 1999 CD cord-298503-l60cdllh 209 1 ; ; : cord-298503-l60cdllh 209 2 Dahm Dahm NNP cord-298503-l60cdllh 209 3 et et NNP cord-298503-l60cdllh 209 4 al al NNP cord-298503-l60cdllh 209 5 . . NNP cord-298503-l60cdllh 209 6 , , , cord-298503-l60cdllh 209 7 2001 2001 CD cord-298503-l60cdllh 209 8 ; ; : cord-298503-l60cdllh 209 9 Sannerud Sannerud NNP cord-298503-l60cdllh 209 10 et et NNP cord-298503-l60cdllh 209 11 al al NNP cord-298503-l60cdllh 209 12 . . NNP cord-298503-l60cdllh 209 13 , , , cord-298503-l60cdllh 209 14 2006 2006 CD cord-298503-l60cdllh 209 15 ; ; : cord-298503-l60cdllh 209 16 Monetta Monetta NNP cord-298503-l60cdllh 209 17 et et NNP cord-298503-l60cdllh 209 18 al al NNP cord-298503-l60cdllh 209 19 . . NNP cord-298503-l60cdllh 209 20 , , , cord-298503-l60cdllh 209 21 2007 2007 CD cord-298503-l60cdllh 210 1 ; ; : cord-298503-l60cdllh 210 2 Tomás Tomás NNP cord-298503-l60cdllh 210 3 et et NNP cord-298503-l60cdllh 210 4 al al NNP cord-298503-l60cdllh 210 5 . . NNP cord-298503-l60cdllh 210 6 , , , cord-298503-l60cdllh 210 7 2010 2010 CD cord-298503-l60cdllh 210 8 ) ) -RRB- cord-298503-l60cdllh 210 9 . . . cord-298503-l60cdllh 211 1 Another another DT cord-298503-l60cdllh 211 2 model model NN cord-298503-l60cdllh 211 3 of of IN cord-298503-l60cdllh 211 4 the the DT cord-298503-l60cdllh 211 5 IC IC NNP cord-298503-l60cdllh 211 6 ( ( -LRB- cord-298503-l60cdllh 211 7 Figure Figure NNP cord-298503-l60cdllh 211 8 7(b 7(b CD cord-298503-l60cdllh 211 9 ) ) -RRB- cord-298503-l60cdllh 211 10 ) ) -RRB- cord-298503-l60cdllh 211 11 is be VBZ cord-298503-l60cdllh 211 12 largely largely RB cord-298503-l60cdllh 211 13 based base VBN cord-298503-l60cdllh 211 14 on on IN cord-298503-l60cdllh 211 15 the the DT cord-298503-l60cdllh 211 16 imaging imaging NN cord-298503-l60cdllh 211 17 of of IN cord-298503-l60cdllh 211 18 GFP GFP NNP cord-298503-l60cdllh 211 19 - - HYPH cord-298503-l60cdllh 211 20 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 211 21 dynamics dynamic NNS cord-298503-l60cdllh 211 22 in in IN cord-298503-l60cdllh 211 23 living living NN cord-298503-l60cdllh 211 24 cells cell NNS cord-298503-l60cdllh 212 1 ( ( -LRB- cord-298503-l60cdllh 212 2 Ben Ben NNP cord-298503-l60cdllh 212 3 - - HYPH cord-298503-l60cdllh 212 4 Tekaya Tekaya NNP cord-298503-l60cdllh 212 5 et et NNP cord-298503-l60cdllh 212 6 al al NNP cord-298503-l60cdllh 212 7 . . NNP cord-298503-l60cdllh 212 8 , , , cord-298503-l60cdllh 212 9 2005 2005 CD cord-298503-l60cdllh 212 10 ) ) -RRB- cord-298503-l60cdllh 212 11 . . . cord-298503-l60cdllh 213 1 It -PRON- PRP cord-298503-l60cdllh 213 2 proposes propose VBZ cord-298503-l60cdllh 213 3 that that IN cord-298503-l60cdllh 213 4 the the DT cord-298503-l60cdllh 213 5 IC IC NNP cord-298503-l60cdllh 213 6 consists consist VBZ cord-298503-l60cdllh 213 7 of of IN cord-298503-l60cdllh 213 8 stationary stationary JJ cord-298503-l60cdllh 213 9 , , , cord-298503-l60cdllh 213 10 long long RB cord-298503-l60cdllh 213 11 - - HYPH cord-298503-l60cdllh 213 12 lived live VBN cord-298503-l60cdllh 213 13 membrane membrane NN cord-298503-l60cdllh 213 14 clusters cluster NNS cord-298503-l60cdllh 213 15 , , , cord-298503-l60cdllh 213 16 located locate VBN cord-298503-l60cdllh 213 17 close close RB cord-298503-l60cdllh 213 18 to to IN cord-298503-l60cdllh 213 19 the the DT cord-298503-l60cdllh 213 20 ERES ERES NNP cord-298503-l60cdllh 213 21 , , , cord-298503-l60cdllh 213 22 which which WDT cord-298503-l60cdllh 213 23 communicate communicate VBP cord-298503-l60cdllh 213 24 with with IN cord-298503-l60cdllh 213 25 the the DT cord-298503-l60cdllh 213 26 ER ER NNP cord-298503-l60cdllh 213 27 and and CC cord-298503-l60cdllh 213 28 Golgi Golgi NNP cord-298503-l60cdllh 213 29 via via IN cord-298503-l60cdllh 213 30 distinct distinct JJ cord-298503-l60cdllh 213 31 transport transport NN cord-298503-l60cdllh 213 32 carriers carrier NNS cord-298503-l60cdllh 213 33 ( ( -LRB- cord-298503-l60cdllh 213 34 Appenzeller Appenzeller NNP cord-298503-l60cdllh 213 35 - - HYPH cord-298503-l60cdllh 213 36 Herzog Herzog NNP cord-298503-l60cdllh 213 37 and and CC cord-298503-l60cdllh 213 38 Hauri Hauri NNP cord-298503-l60cdllh 213 39 , , , cord-298503-l60cdllh 213 40 2006 2006 CD cord-298503-l60cdllh 213 41 ) ) -RRB- cord-298503-l60cdllh 213 42 . . . cord-298503-l60cdllh 214 1 Thus thus RB cord-298503-l60cdllh 214 2 , , , cord-298503-l60cdllh 214 3 in in IN cord-298503-l60cdllh 214 4 a a DT cord-298503-l60cdllh 214 5 two two CD cord-298503-l60cdllh 214 6 - - HYPH cord-298503-l60cdllh 214 7 step step NN cord-298503-l60cdllh 214 8 transport transport NN cord-298503-l60cdllh 214 9 process process NN cord-298503-l60cdllh 214 10 cargo cargo NN cord-298503-l60cdllh 214 11 is be VBZ cord-298503-l60cdllh 214 12 first first RB cord-298503-l60cdllh 214 13 transfered transfer VBN cord-298503-l60cdllh 214 14 from from IN cord-298503-l60cdllh 214 15 ER ER NNP cord-298503-l60cdllh 214 16 to to IN cord-298503-l60cdllh 214 17 the the DT cord-298503-l60cdllh 214 18 IC IC NNP cord-298503-l60cdllh 214 19 via via IN cord-298503-l60cdllh 214 20 heterotypic heterotypic NNP cord-298503-l60cdllh 214 21 fusion fusion NN cord-298503-l60cdllh 214 22 of of IN cord-298503-l60cdllh 214 23 COPII COPII NNP cord-298503-l60cdllh 214 24 vesicles vesicle NNS cord-298503-l60cdllh 214 25 . . . cord-298503-l60cdllh 215 1 The the DT cord-298503-l60cdllh 215 2 IC IC NNP cord-298503-l60cdllh 215 3 then then RB cord-298503-l60cdllh 215 4 generates generate VBZ cord-298503-l60cdllh 215 5 novel novel NN cord-298503-l60cdllh 215 6 ( ( -LRB- cord-298503-l60cdllh 215 7 possibly possibly RB cord-298503-l60cdllh 215 8 COPI COPI NNP cord-298503-l60cdllh 215 9 - - HYPH cord-298503-l60cdllh 215 10 coated coat VBN cord-298503-l60cdllh 215 11 ) ) -RRB- cord-298503-l60cdllh 215 12 anterograde anterograde JJ cord-298503-l60cdllh 215 13 carriers carrier NNS cord-298503-l60cdllh 215 14 ( ( -LRB- cord-298503-l60cdllh 215 15 ACs ACs NNP cord-298503-l60cdllh 215 16 ) ) -RRB- cord-298503-l60cdllh 215 17 that that WDT cord-298503-l60cdllh 215 18 move move VBP cord-298503-l60cdllh 215 19 along along IN cord-298503-l60cdllh 215 20 MTs MTs NNP cord-298503-l60cdllh 215 21 to to IN cord-298503-l60cdllh 215 22 the the DT cord-298503-l60cdllh 215 23 cis cis NNP cord-298503-l60cdllh 215 24 - - HYPH cord-298503-l60cdllh 215 25 Golgi Golgi NNP cord-298503-l60cdllh 215 26 . . . cord-298503-l60cdllh 216 1 The the DT cord-298503-l60cdllh 216 2 recycling recycling NN cord-298503-l60cdllh 216 3 of of IN cord-298503-l60cdllh 216 4 GFP GFP NNP cord-298503-l60cdllh 216 5 - - HYPH cord-298503-l60cdllh 216 6 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 216 7 to to IN cord-298503-l60cdllh 216 8 the the DT cord-298503-l60cdllh 216 9 ER ER NNP cord-298503-l60cdllh 216 10 evidently evidently RB cord-298503-l60cdllh 216 11 occurs occur VBZ cord-298503-l60cdllh 216 12 mainly mainly RB cord-298503-l60cdllh 216 13 from from IN cord-298503-l60cdllh 216 14 the the DT cord-298503-l60cdllh 216 15 ERES ERES NNP cord-298503-l60cdllh 216 16 - - HYPH cord-298503-l60cdllh 216 17 associated associate VBN cord-298503-l60cdllh 216 18 IC IC NNP cord-298503-l60cdllh 216 19 , , , cord-298503-l60cdllh 216 20 since since IN cord-298503-l60cdllh 216 21 it -PRON- PRP cord-298503-l60cdllh 216 22 was be VBD cord-298503-l60cdllh 216 23 not not RB cord-298503-l60cdllh 216 24 detected detect VBN cord-298503-l60cdllh 216 25 in in IN cord-298503-l60cdllh 216 26 the the DT cord-298503-l60cdllh 216 27 ACs ac NNS cord-298503-l60cdllh 216 28 containing contain VBG cord-298503-l60cdllh 216 29 soluble soluble JJ cord-298503-l60cdllh 216 30 , , , cord-298503-l60cdllh 216 31 Golgi Golgi NNP cord-298503-l60cdllh 216 32 - - HYPH cord-298503-l60cdllh 216 33 destined destine VBN cord-298503-l60cdllh 216 34 cargo cargo NN cord-298503-l60cdllh 216 35 . . . cord-298503-l60cdllh 217 1 The the DT cord-298503-l60cdllh 217 2 identification identification NN cord-298503-l60cdllh 217 3 of of IN cord-298503-l60cdllh 217 4 a a DT cord-298503-l60cdllh 217 5 motif motif NN cord-298503-l60cdllh 217 6 in in IN cord-298503-l60cdllh 217 7 the the DT cord-298503-l60cdllh 217 8 neuronal neuronal JJ cord-298503-l60cdllh 217 9 GABA GABA NNP cord-298503-l60cdllh 217 10 transporter transporter NN cord-298503-l60cdllh 217 11 , , , cord-298503-l60cdllh 217 12 that that DT cord-298503-l60cdllh 217 13 seems seem VBZ cord-298503-l60cdllh 217 14 to to TO cord-298503-l60cdllh 217 15 be be VB cord-298503-l60cdllh 217 16 required require VBN cord-298503-l60cdllh 217 17 for for IN cord-298503-l60cdllh 217 18 its -PRON- PRP$ cord-298503-l60cdllh 217 19 exit exit NN cord-298503-l60cdllh 217 20 from from IN cord-298503-l60cdllh 217 21 the the DT cord-298503-l60cdllh 217 22 IC IC NNP cord-298503-l60cdllh 217 23 , , , cord-298503-l60cdllh 217 24 supports support VBZ cord-298503-l60cdllh 217 25 the the DT cord-298503-l60cdllh 217 26 stable stable JJ cord-298503-l60cdllh 217 27 nature nature NN cord-298503-l60cdllh 217 28 of of IN cord-298503-l60cdllh 217 29 the the DT cord-298503-l60cdllh 217 30 IC IC NNP cord-298503-l60cdllh 217 31 ( ( -LRB- cord-298503-l60cdllh 217 32 Farhan Farhan NNP cord-298503-l60cdllh 217 33 et et NNP cord-298503-l60cdllh 217 34 al al NNP cord-298503-l60cdllh 217 35 . . NNP cord-298503-l60cdllh 217 36 , , , cord-298503-l60cdllh 217 37 2008 2008 CD cord-298503-l60cdllh 217 38 ) ) -RRB- cord-298503-l60cdllh 217 39 . . . cord-298503-l60cdllh 218 1 Visualization visualization NN cord-298503-l60cdllh 218 2 of of IN cord-298503-l60cdllh 218 3 IC IC NNP cord-298503-l60cdllh 218 4 dynamics dynamic NNS cord-298503-l60cdllh 218 5 using use VBG cord-298503-l60cdllh 218 6 GFP GFP NNP cord-298503-l60cdllh 218 7 - - HYPH cord-298503-l60cdllh 218 8 Rab1A Rab1A NNS cord-298503-l60cdllh 218 9 showed show VBD cord-298503-l60cdllh 218 10 that that IN cord-298503-l60cdllh 218 11 the the DT cord-298503-l60cdllh 218 12 pleiomorphic pleiomorphic JJ cord-298503-l60cdllh 218 13 transport transport NN cord-298503-l60cdllh 218 14 carriers carrier NNS cord-298503-l60cdllh 218 15 arriving arrive VBG cord-298503-l60cdllh 218 16 along along IN cord-298503-l60cdllh 218 17 MTs MTs NNP cord-298503-l60cdllh 218 18 from from IN cord-298503-l60cdllh 218 19 the the DT cord-298503-l60cdllh 218 20 cell cell NN cord-298503-l60cdllh 218 21 periphery periphery NN cord-298503-l60cdllh 218 22 do do VBP cord-298503-l60cdllh 218 23 not not RB cord-298503-l60cdllh 218 24 move move VB cord-298503-l60cdllh 218 25 directly directly RB cord-298503-l60cdllh 218 26 to to IN cord-298503-l60cdllh 218 27 cis cis NNP cord-298503-l60cdllh 218 28 - - HYPH cord-298503-l60cdllh 218 29 Golgi Golgi NNP cord-298503-l60cdllh 218 30 , , , cord-298503-l60cdllh 218 31 but but CC cord-298503-l60cdllh 218 32 are be VBP cord-298503-l60cdllh 218 33 targeted target VBN cord-298503-l60cdllh 218 34 to to IN cord-298503-l60cdllh 218 35 the the DT cord-298503-l60cdllh 218 36 MTOC MTOC NNP cord-298503-l60cdllh 218 37 / / SYM cord-298503-l60cdllh 218 38 centrosome centrosome NN cord-298503-l60cdllh 218 39 that that WDT cord-298503-l60cdllh 218 40 is be VBZ cord-298503-l60cdllh 218 41 normally normally RB cord-298503-l60cdllh 218 42 positioned position VBN cord-298503-l60cdllh 218 43 next next RB cord-298503-l60cdllh 218 44 to to IN cord-298503-l60cdllh 218 45 the the DT cord-298503-l60cdllh 218 46 Golgi Golgi NNP cord-298503-l60cdllh 218 47 ribbon ribbon NN cord-298503-l60cdllh 218 48 . . . cord-298503-l60cdllh 219 1 In in IN cord-298503-l60cdllh 219 2 cells cell NNS cord-298503-l60cdllh 219 3 displaying display VBG cord-298503-l60cdllh 219 4 centrosome centrosome NN cord-298503-l60cdllh 219 5 motility motility NN cord-298503-l60cdllh 219 6 , , , cord-298503-l60cdllh 219 7 for for IN cord-298503-l60cdllh 219 8 example example NN cord-298503-l60cdllh 219 9 , , , cord-298503-l60cdllh 219 10 cells cell NNS cord-298503-l60cdllh 219 11 that that WDT cord-298503-l60cdllh 219 12 are be VBP cord-298503-l60cdllh 219 13 migrating migrate VBG cord-298503-l60cdllh 219 14 or or CC cord-298503-l60cdllh 219 15 entering enter VBG cord-298503-l60cdllh 219 16 mitosis mitosis NN cord-298503-l60cdllh 219 17 , , , cord-298503-l60cdllh 219 18 the the DT cord-298503-l60cdllh 219 19 centrosome centrosome NN cord-298503-l60cdllh 219 20 - - HYPH cord-298503-l60cdllh 219 21 targeted target VBN cord-298503-l60cdllh 219 22 membranes membrane NNS cord-298503-l60cdllh 219 23 can can MD cord-298503-l60cdllh 219 24 be be VB cord-298503-l60cdllh 219 25 resolved resolve VBN cord-298503-l60cdllh 219 26 as as IN cord-298503-l60cdllh 219 27 a a DT cord-298503-l60cdllh 219 28 separate separate JJ cord-298503-l60cdllh 219 29 compartment compartment NN cord-298503-l60cdllh 219 30 , , , cord-298503-l60cdllh 219 31 called call VBD cord-298503-l60cdllh 219 32 the the DT cord-298503-l60cdllh 219 33 pericentrosomal pericentrosomal JJ cord-298503-l60cdllh 219 34 IC IC NNP cord-298503-l60cdllh 219 35 ( ( -LRB- cord-298503-l60cdllh 219 36 pcIC pcIC NNP cord-298503-l60cdllh 219 37 ) ) -RRB- cord-298503-l60cdllh 219 38 , , , cord-298503-l60cdllh 219 39 which which WDT cord-298503-l60cdllh 219 40 is be VBZ cord-298503-l60cdllh 219 41 distinct distinct JJ cord-298503-l60cdllh 219 42 from from IN cord-298503-l60cdllh 219 43 the the DT cord-298503-l60cdllh 219 44 cis cis NNP cord-298503-l60cdllh 219 45 - - HYPH cord-298503-l60cdllh 219 46 Golgi Golgi NNP cord-298503-l60cdllh 219 47 - - HYPH cord-298503-l60cdllh 219 48 adjacent adjacent JJ cord-298503-l60cdllh 219 49 IC IC NNP cord-298503-l60cdllh 219 50 domain domain NN cord-298503-l60cdllh 219 51 ( ( -LRB- cord-298503-l60cdllh 219 52 Marie Marie NNP cord-298503-l60cdllh 219 53 et et NNP cord-298503-l60cdllh 219 54 al al NNP cord-298503-l60cdllh 219 55 . . NNP cord-298503-l60cdllh 219 56 , , , cord-298503-l60cdllh 219 57 , , , cord-298503-l60cdllh 219 58 2012 2012 CD cord-298503-l60cdllh 219 59 Mochizuki Mochizuki NNP cord-298503-l60cdllh 219 60 et et NNP cord-298503-l60cdllh 219 61 al al NNP cord-298503-l60cdllh 219 62 . . NNP cord-298503-l60cdllh 219 63 , , , cord-298503-l60cdllh 219 64 2013 2013 CD cord-298503-l60cdllh 219 65 ; ; : cord-298503-l60cdllh 219 66 Figure figure NN cord-298503-l60cdllh 219 67 3 3 CD cord-298503-l60cdllh 219 68 ( ( -LRB- cord-298503-l60cdllh 219 69 a a NN cord-298503-l60cdllh 219 70 ) ) -RRB- cord-298503-l60cdllh 219 71 ) ) -RRB- cord-298503-l60cdllh 219 72 . . . cord-298503-l60cdllh 220 1 Live live JJ cord-298503-l60cdllh 220 2 imaging imaging NN cord-298503-l60cdllh 220 3 further further RB cord-298503-l60cdllh 220 4 showed show VBD cord-298503-l60cdllh 220 5 that that IN cord-298503-l60cdllh 220 6 the the DT cord-298503-l60cdllh 220 7 separated separated JJ cord-298503-l60cdllh 220 8 pcIC pcic NN cord-298503-l60cdllh 220 9 and and CC cord-298503-l60cdllh 220 10 the the DT cord-298503-l60cdllh 220 11 Golgi Golgi NNP cord-298503-l60cdllh 220 12 communicate communicate VB cord-298503-l60cdllh 220 13 via via IN cord-298503-l60cdllh 220 14 tubular tubular JJ cord-298503-l60cdllh 220 15 and and CC cord-298503-l60cdllh 220 16 globular globular JJ cord-298503-l60cdllh 220 17 carriers carrier NNS cord-298503-l60cdllh 220 18 . . . cord-298503-l60cdllh 221 1 The the DT cord-298503-l60cdllh 221 2 pcIC pcic NN cord-298503-l60cdllh 221 3 contains contain VBZ cord-298503-l60cdllh 221 4 its -PRON- PRP$ cord-298503-l60cdllh 221 5 own own JJ cord-298503-l60cdllh 221 6 pool pool NN cord-298503-l60cdllh 221 7 of of IN cord-298503-l60cdllh 221 8 COPI COPI NNP cord-298503-l60cdllh 221 9 coats coat NNS cord-298503-l60cdllh 221 10 , , , cord-298503-l60cdllh 221 11 and and CC cord-298503-l60cdllh 221 12 mediates mediate VBZ cord-298503-l60cdllh 221 13 the the DT cord-298503-l60cdllh 221 14 BFAinduced bfainduce VBN cord-298503-l60cdllh 221 15 , , , cord-298503-l60cdllh 221 16 COPI COPI NNP cord-298503-l60cdllh 221 17 - - HYPH cord-298503-l60cdllh 221 18 independent independent JJ cord-298503-l60cdllh 221 19 backflow backflow NN cord-298503-l60cdllh 221 20 of of IN cord-298503-l60cdllh 221 21 Golgi Golgi NNP cord-298503-l60cdllh 221 22 enzymes enzyme NNS cord-298503-l60cdllh 221 23 to to IN cord-298503-l60cdllh 221 24 the the DT cord-298503-l60cdllh 221 25 ER ER NNP cord-298503-l60cdllh 221 26 , , , cord-298503-l60cdllh 221 27 suggesting suggest VBG cord-298503-l60cdllh 221 28 that that IN cord-298503-l60cdllh 221 29 forward forward JJ cord-298503-l60cdllh 221 30 pcIC pcic NN cord-298503-l60cdllh 221 31 - - HYPH cord-298503-l60cdllh 221 32 to to IN cord-298503-l60cdllh 221 33 - - HYPH cord-298503-l60cdllh 221 34 Golgi golgi NN cord-298503-l60cdllh 221 35 transport transport NN cord-298503-l60cdllh 221 36 depends depend VBZ cord-298503-l60cdllh 221 37 on on IN cord-298503-l60cdllh 221 38 COPI COPI NNP cord-298503-l60cdllh 221 39 coats coat NNS cord-298503-l60cdllh 221 40 , , , cord-298503-l60cdllh 221 41 and and CC cord-298503-l60cdllh 221 42 thus thus RB cord-298503-l60cdllh 221 43 is be VBZ cord-298503-l60cdllh 221 44 blocked block VBN cord-298503-l60cdllh 221 45 by by IN cord-298503-l60cdllh 221 46 BFA BFA NNP cord-298503-l60cdllh 221 47 . . . cord-298503-l60cdllh 222 1 Both both DT cord-298503-l60cdllh 222 2 the the DT cord-298503-l60cdllh 222 3 peripheral peripheral JJ cord-298503-l60cdllh 222 4 IC IC NNP cord-298503-l60cdllh 222 5 elements element NNS cord-298503-l60cdllh 222 6 and and CC cord-298503-l60cdllh 222 7 the the DT cord-298503-l60cdllh 222 8 pcIC pcic NN cord-298503-l60cdllh 222 9 persist persist VB cord-298503-l60cdllh 222 10 upon upon IN cord-298503-l60cdllh 222 11 Golgi Golgi NNP cord-298503-l60cdllh 222 12 disassembly disassembly NN cord-298503-l60cdllh 222 13 by by IN cord-298503-l60cdllh 222 14 BFA BFA NNP cord-298503-l60cdllh 222 15 and and CC cord-298503-l60cdllh 222 16 maintain maintain VB cord-298503-l60cdllh 222 17 their -PRON- PRP$ cord-298503-l60cdllh 222 18 communication communication NN cord-298503-l60cdllh 222 19 with with IN cord-298503-l60cdllh 222 20 via via IN cord-298503-l60cdllh 222 21 dynamic dynamic JJ cord-298503-l60cdllh 222 22 tubules tubule NNS cord-298503-l60cdllh 222 23 . . . cord-298503-l60cdllh 223 1 Accordingly accordingly RB cord-298503-l60cdllh 223 2 , , , cord-298503-l60cdllh 223 3 the the DT cord-298503-l60cdllh 223 4 IC IC NNP cord-298503-l60cdllh 223 5 has have VBZ cord-298503-l60cdllh 223 6 been be VBN cord-298503-l60cdllh 223 7 proposed propose VBN cord-298503-l60cdllh 223 8 to to TO cord-298503-l60cdllh 223 9 constitute constitute VB cord-298503-l60cdllh 223 10 a a DT cord-298503-l60cdllh 223 11 dynamic dynamic JJ cord-298503-l60cdllh 223 12 , , , cord-298503-l60cdllh 223 13 but but CC cord-298503-l60cdllh 223 14 stable stable JJ cord-298503-l60cdllh 223 15 membrane membrane NN cord-298503-l60cdllh 223 16 network network NN cord-298503-l60cdllh 223 17 due due IN cord-298503-l60cdllh 223 18 to to IN cord-298503-l60cdllh 223 19 its -PRON- PRP$ cord-298503-l60cdllh 223 20 anchoring anchoring NN cord-298503-l60cdllh 223 21 next next RB cord-298503-l60cdllh 223 22 to to IN cord-298503-l60cdllh 223 23 the the DT cord-298503-l60cdllh 223 24 ERES ERES NNP cord-298503-l60cdllh 223 25 and and CC cord-298503-l60cdllh 223 26 the the DT cord-298503-l60cdllh 223 27 centrosome centrosome NN cord-298503-l60cdllh 223 28 Figure Figure NNP cord-298503-l60cdllh 223 29 7(c 7(c CD cord-298503-l60cdllh 223 30 ) ) -RRB- cord-298503-l60cdllh 223 31 ) ) -RRB- cord-298503-l60cdllh 223 32 . . . cord-298503-l60cdllh 224 1 This this DT cord-298503-l60cdllh 224 2 model model NN cord-298503-l60cdllh 224 3 is be VBZ cord-298503-l60cdllh 224 4 supported support VBN cord-298503-l60cdllh 224 5 by by IN cord-298503-l60cdllh 224 6 studies study NNS cord-298503-l60cdllh 224 7 of of IN cord-298503-l60cdllh 224 8 mitotic mitotic JJ cord-298503-l60cdllh 224 9 cells cell NNS cord-298503-l60cdllh 224 10 , , , cord-298503-l60cdllh 224 11 showing show VBG cord-298503-l60cdllh 224 12 that that IN cord-298503-l60cdllh 224 13 the the DT cord-298503-l60cdllh 224 14 IC IC NNP cord-298503-l60cdllh 224 15 persists persist VBZ cord-298503-l60cdllh 224 16 despite despite IN cord-298503-l60cdllh 224 17 Golgi Golgi NNP cord-298503-l60cdllh 224 18 breakdown breakdown NN cord-298503-l60cdllh 224 19 and and CC cord-298503-l60cdllh 224 20 the the DT cord-298503-l60cdllh 224 21 rearrangement rearrangement NN cord-298503-l60cdllh 224 22 of of IN cord-298503-l60cdllh 224 23 the the DT cord-298503-l60cdllh 224 24 MTs mt NNS cord-298503-l60cdllh 224 25 , , , cord-298503-l60cdllh 224 26 and and CC cord-298503-l60cdllh 224 27 maintains maintain VBZ cord-298503-l60cdllh 224 28 its -PRON- PRP$ cord-298503-l60cdllh 224 29 spatial spatial JJ cord-298503-l60cdllh 224 30 organization organization NN cord-298503-l60cdllh 224 31 due due IN cord-298503-l60cdllh 224 32 to to IN cord-298503-l60cdllh 224 33 its -PRON- PRP$ cord-298503-l60cdllh 224 34 ongoing ongoing JJ cord-298503-l60cdllh 224 35 association association NN cord-298503-l60cdllh 224 36 with with IN cord-298503-l60cdllh 224 37 the the DT cord-298503-l60cdllh 224 38 spindle spindle NN cord-298503-l60cdllh 224 39 MTs mt NNS cord-298503-l60cdllh 224 40 and and CC cord-298503-l60cdllh 224 41 the the DT cord-298503-l60cdllh 224 42 centrosomes centrosome NNS cord-298503-l60cdllh 224 43 at at IN cord-298503-l60cdllh 224 44 the the DT cord-298503-l60cdllh 224 45 spindle spindle NN cord-298503-l60cdllh 224 46 poles pole NNS cord-298503-l60cdllh 225 1 ( ( -LRB- cord-298503-l60cdllh 225 2 Marie Marie NNP cord-298503-l60cdllh 225 3 et et NNP cord-298503-l60cdllh 225 4 al al NNP cord-298503-l60cdllh 225 5 . . NNP cord-298503-l60cdllh 225 6 , , , cord-298503-l60cdllh 225 7 2012 2012 CD cord-298503-l60cdllh 225 8 ; ; : cord-298503-l60cdllh 225 9 Figure figure NN cord-298503-l60cdllh 225 10 3(a 3(a CD cord-298503-l60cdllh 225 11 ) ) -RRB- cord-298503-l60cdllh 225 12 ) ) -RRB- cord-298503-l60cdllh 225 13 . . . cord-298503-l60cdllh 226 1 In in IN cord-298503-l60cdllh 226 2 the the DT cord-298503-l60cdllh 226 3 endocytic endocytic JJ cord-298503-l60cdllh 226 4 pathway pathway NN cord-298503-l60cdllh 226 5 , , , cord-298503-l60cdllh 226 6 soluble soluble JJ cord-298503-l60cdllh 226 7 proteins protein NNS cord-298503-l60cdllh 226 8 and and CC cord-298503-l60cdllh 226 9 particles particle NNS cord-298503-l60cdllh 226 10 bound bind VBN cord-298503-l60cdllh 226 11 to to IN cord-298503-l60cdllh 226 12 lysosomes lysosome NNS cord-298503-l60cdllh 226 13 accumulate accumulate VBP cord-298503-l60cdllh 226 14 in in IN cord-298503-l60cdllh 226 15 the the DT cord-298503-l60cdllh 226 16 lumen lumen NN cord-298503-l60cdllh 226 17 of of IN cord-298503-l60cdllh 226 18 vacuolar vacuolar NNP cord-298503-l60cdllh 226 19 endosomes endosome VBZ cord-298503-l60cdllh 226 20 , , , cord-298503-l60cdllh 226 21 while while IN cord-298503-l60cdllh 226 22 many many JJ cord-298503-l60cdllh 226 23 membrane membrane NN cord-298503-l60cdllh 226 24 proteins protein NNS cord-298503-l60cdllh 226 25 are be VBP cord-298503-l60cdllh 226 26 sorted sort VBN cord-298503-l60cdllh 226 27 into into IN cord-298503-l60cdllh 226 28 narrow narrow JJ cord-298503-l60cdllh 226 29 tubules tubule NNS cord-298503-l60cdllh 226 30 for for IN cord-298503-l60cdllh 226 31 recycling recycling NN cord-298503-l60cdllh 226 32 to to IN cord-298503-l60cdllh 226 33 the the DT cord-298503-l60cdllh 226 34 PM pm NN cord-298503-l60cdllh 226 35 . . . cord-298503-l60cdllh 227 1 The the DT cord-298503-l60cdllh 227 2 observed observed JJ cord-298503-l60cdllh 227 3 major major NN cord-298503-l60cdllh 227 4 The the DT cord-298503-l60cdllh 227 5 IC IC NNP cord-298503-l60cdllh 227 6 consists consist VBZ cord-298503-l60cdllh 227 7 of of IN cord-298503-l60cdllh 227 8 stationary stationary JJ cord-298503-l60cdllh 227 9 membrane membrane NN cord-298503-l60cdllh 227 10 clusters cluster NNS cord-298503-l60cdllh 227 11 located locate VBN cord-298503-l60cdllh 227 12 close close RB cord-298503-l60cdllh 227 13 to to IN cord-298503-l60cdllh 227 14 ERES ERES NNP cord-298503-l60cdllh 227 15 . . . cord-298503-l60cdllh 228 1 In in IN cord-298503-l60cdllh 228 2 this this DT cord-298503-l60cdllh 228 3 case case NN cord-298503-l60cdllh 228 4 ER er NN cord-298503-l60cdllh 228 5 - - HYPH cord-298503-l60cdllh 228 6 to to IN cord-298503-l60cdllh 228 7 - - HYPH cord-298503-l60cdllh 228 8 Golgi golgi NN cord-298503-l60cdllh 228 9 trafficking trafficking NN cord-298503-l60cdllh 228 10 involves involve VBZ cord-298503-l60cdllh 228 11 two two CD cord-298503-l60cdllh 228 12 distinct distinct JJ cord-298503-l60cdllh 228 13 transport transport NN cord-298503-l60cdllh 228 14 steps step NNS cord-298503-l60cdllh 228 15 , , , cord-298503-l60cdllh 228 16 since since IN cord-298503-l60cdllh 228 17 the the DT cord-298503-l60cdllh 228 18 IC IC NNP cord-298503-l60cdllh 228 19 recieves recieve VBZ cord-298503-l60cdllh 228 20 cargo cargo NN cord-298503-l60cdllh 228 21 from from IN cord-298503-l60cdllh 228 22 the the DT cord-298503-l60cdllh 228 23 ER ER NNP cord-298503-l60cdllh 228 24 via via IN cord-298503-l60cdllh 228 25 heterotypic heterotypic NNP cord-298503-l60cdllh 228 26 fusion fusion NN cord-298503-l60cdllh 228 27 of of IN cord-298503-l60cdllh 228 28 COPII COPII NNP cord-298503-l60cdllh 228 29 vesicles vesicle NNS cord-298503-l60cdllh 228 30 and and CC cord-298503-l60cdllh 228 31 forms form VBZ cord-298503-l60cdllh 228 32 special special JJ cord-298503-l60cdllh 228 33 anterograde anterograde JJ cord-298503-l60cdllh 228 34 carriers carrier NNS cord-298503-l60cdllh 228 35 ( ( -LRB- cord-298503-l60cdllh 228 36 AC AC NNP cord-298503-l60cdllh 228 37 ) ) -RRB- cord-298503-l60cdllh 228 38 that that WDT cord-298503-l60cdllh 228 39 move move VBP cord-298503-l60cdllh 228 40 along along IN cord-298503-l60cdllh 228 41 MTs MTs NNP cord-298503-l60cdllh 228 42 to to IN cord-298503-l60cdllh 228 43 cis cis NNP cord-298503-l60cdllh 228 44 - - HYPH cord-298503-l60cdllh 228 45 Golgi Golgi NNP cord-298503-l60cdllh 228 46 . . . cord-298503-l60cdllh 229 1 ( ( -LRB- cord-298503-l60cdllh 229 2 c c NN cord-298503-l60cdllh 229 3 ) ) -RRB- cord-298503-l60cdllh 230 1 The the DT cord-298503-l60cdllh 230 2 IC IC NNP cord-298503-l60cdllh 230 3 represents represent VBZ cord-298503-l60cdllh 230 4 a a DT cord-298503-l60cdllh 230 5 stable stable JJ cord-298503-l60cdllh 230 6 interconnected interconnected JJ cord-298503-l60cdllh 230 7 network network NN cord-298503-l60cdllh 230 8 that that WDT cord-298503-l60cdllh 230 9 is be VBZ cord-298503-l60cdllh 230 10 anchored anchor VBN cord-298503-l60cdllh 230 11 both both CC cord-298503-l60cdllh 230 12 next next JJ cord-298503-l60cdllh 230 13 to to IN cord-298503-l60cdllh 230 14 ERES ERES NNP cord-298503-l60cdllh 230 15 and and CC cord-298503-l60cdllh 230 16 the the DT cord-298503-l60cdllh 230 17 centrosome centrosome NN cord-298503-l60cdllh 230 18 . . . cord-298503-l60cdllh 231 1 Bidirectional bidirectional JJ cord-298503-l60cdllh 231 2 transport transport NN cord-298503-l60cdllh 231 3 between between IN cord-298503-l60cdllh 231 4 these these DT cord-298503-l60cdllh 231 5 sites site NNS cord-298503-l60cdllh 231 6 and and CC cord-298503-l60cdllh 231 7 between between IN cord-298503-l60cdllh 231 8 the the DT cord-298503-l60cdllh 231 9 central central JJ cord-298503-l60cdllh 231 10 IC IC NNP cord-298503-l60cdllh 231 11 elements element NNS cord-298503-l60cdllh 231 12 and and CC cord-298503-l60cdllh 231 13 the the DT cord-298503-l60cdllh 231 14 Golgi Golgi NNP cord-298503-l60cdllh 231 15 stacks stack NNS cord-298503-l60cdllh 231 16 involves involve VBZ cord-298503-l60cdllh 231 17 vesicular vesicular JJ cord-298503-l60cdllh 231 18 , , , cord-298503-l60cdllh 231 19 tubular tubular JJ cord-298503-l60cdllh 231 20 or or CC cord-298503-l60cdllh 231 21 saccular saccular JJ cord-298503-l60cdllh 231 22 carriers carrier NNS cord-298503-l60cdllh 231 23 . . . cord-298503-l60cdllh 232 1 ERES ERES NNP cord-298503-l60cdllh 232 2 - - HYPH cord-298503-l60cdllh 232 3 IC IC NNP cord-298503-l60cdllh 232 4 communication communication NN cord-298503-l60cdllh 232 5 via via IN cord-298503-l60cdllh 232 6 COPII COPII NNP cord-298503-l60cdllh 232 7 vesicles vesicle NNS cord-298503-l60cdllh 232 8 occurs occur VBZ cord-298503-l60cdllh 232 9 as as IN cord-298503-l60cdllh 232 10 in in IN cord-298503-l60cdllh 232 11 model model NN cord-298503-l60cdllh 232 12 b. b. NN cord-298503-l60cdllh 232 13 COPI COPI NNP cord-298503-l60cdllh 232 14 , , , cord-298503-l60cdllh 232 15 COPII COPII NNP cord-298503-l60cdllh 232 16 and and CC cord-298503-l60cdllh 232 17 clathrin clathrin NN cord-298503-l60cdllh 232 18 coats coat NNS cord-298503-l60cdllh 232 19 are be VBP cord-298503-l60cdllh 232 20 shown show VBN cord-298503-l60cdllh 232 21 in in IN cord-298503-l60cdllh 232 22 gray gray JJ cord-298503-l60cdllh 232 23 , , , cord-298503-l60cdllh 232 24 orange orange JJ cord-298503-l60cdllh 232 25 , , , cord-298503-l60cdllh 232 26 and and CC cord-298503-l60cdllh 232 27 blue blue JJ cord-298503-l60cdllh 232 28 , , , cord-298503-l60cdllh 232 29 respectively respectively RB cord-298503-l60cdllh 232 30 , , , cord-298503-l60cdllh 232 31 and and CC cord-298503-l60cdllh 232 32 the the DT cord-298503-l60cdllh 232 33 centrosome centrosome NN cord-298503-l60cdllh 232 34 in in IN cord-298503-l60cdllh 232 35 red red NN cord-298503-l60cdllh 232 36 . . . cord-298503-l60cdllh 233 1 concentration concentration NN cord-298503-l60cdllh 233 2 of of IN cord-298503-l60cdllh 233 3 soluble soluble JJ cord-298503-l60cdllh 233 4 secretory secretory JJ cord-298503-l60cdllh 233 5 proteins protein NNS cord-298503-l60cdllh 233 6 within within IN cord-298503-l60cdllh 233 7 the the DT cord-298503-l60cdllh 233 8 IC IC NNP cord-298503-l60cdllh 233 9 ( ( -LRB- cord-298503-l60cdllh 233 10 Oprins Oprins NNP cord-298503-l60cdllh 233 11 et et NNP cord-298503-l60cdllh 233 12 al al NNP cord-298503-l60cdllh 233 13 . . NNP cord-298503-l60cdllh 233 14 , , , cord-298503-l60cdllh 233 15 2001 2001 CD cord-298503-l60cdllh 233 16 ) ) -RRB- cord-298503-l60cdllh 233 17 could could MD cord-298503-l60cdllh 233 18 be be VB cord-298503-l60cdllh 233 19 explained explain VBN cord-298503-l60cdllh 233 20 by by IN cord-298503-l60cdllh 233 21 similar similar JJ cord-298503-l60cdllh 233 22 geometrybased geometrybased JJ cord-298503-l60cdllh 233 23 sorting sorting NN cord-298503-l60cdllh 233 24 , , , cord-298503-l60cdllh 233 25 namely namely RB cord-298503-l60cdllh 233 26 , , , cord-298503-l60cdllh 233 27 their -PRON- PRP$ cord-298503-l60cdllh 233 28 exclusion exclusion NN cord-298503-l60cdllh 233 29 from from IN cord-298503-l60cdllh 233 30 vesicles vesicle NNS cord-298503-l60cdllh 233 31 and and CC cord-298503-l60cdllh 233 32 tubules tubule NNS cord-298503-l60cdllh 233 33 , , , cord-298503-l60cdllh 233 34 which which WDT cord-298503-l60cdllh 233 35 recycle recycle VBP cord-298503-l60cdllh 233 36 lipids lipid NNS cord-298503-l60cdllh 233 37 and and CC cord-298503-l60cdllh 233 38 membrane membrane NN cord-298503-l60cdllh 233 39 - - HYPH cord-298503-l60cdllh 233 40 bound bind VBN cord-298503-l60cdllh 233 41 proteins protein NNS cord-298503-l60cdllh 233 42 back back RB cord-298503-l60cdllh 233 43 to to IN cord-298503-l60cdllh 233 44 the the DT cord-298503-l60cdllh 233 45 ER er NN cord-298503-l60cdllh 234 1 ( ( -LRB- cord-298503-l60cdllh 234 2 Martínez Martínez NNP cord-298503-l60cdllh 234 3 - - HYPH cord-298503-l60cdllh 234 4 Menárguez Menárguez NNP cord-298503-l60cdllh 234 5 et et NNP cord-298503-l60cdllh 234 6 al al NNP cord-298503-l60cdllh 234 7 . . NNP cord-298503-l60cdllh 234 8 , , , cord-298503-l60cdllh 234 9 1999 1999 CD cord-298503-l60cdllh 234 10 ) ) -RRB- cord-298503-l60cdllh 234 11 . . . cord-298503-l60cdllh 235 1 Membrane membrane NN cord-298503-l60cdllh 235 2 recycling recycling NN cord-298503-l60cdllh 235 3 is be VBZ cord-298503-l60cdllh 235 4 a a DT cord-298503-l60cdllh 235 5 major major JJ cord-298503-l60cdllh 235 6 function function NN cord-298503-l60cdllh 235 7 of of IN cord-298503-l60cdllh 235 8 both both CC cord-298503-l60cdllh 235 9 the the DT cord-298503-l60cdllh 235 10 IC IC NNP cord-298503-l60cdllh 235 11 and and CC cord-298503-l60cdllh 235 12 endosomes endosome NNS cord-298503-l60cdllh 235 13 in in IN cord-298503-l60cdllh 235 14 mammalian mammalian JJ cord-298503-l60cdllh 235 15 cells cell NNS cord-298503-l60cdllh 235 16 . . . cord-298503-l60cdllh 236 1 Due due IN cord-298503-l60cdllh 236 2 to to IN cord-298503-l60cdllh 236 3 the the DT cord-298503-l60cdllh 236 4 similarity similarity NN cord-298503-l60cdllh 236 5 of of IN cord-298503-l60cdllh 236 6 the the DT cord-298503-l60cdllh 236 7 tubular tubular JJ cord-298503-l60cdllh 236 8 domain domain NN cord-298503-l60cdllh 236 9 of of IN cord-298503-l60cdllh 236 10 the the DT cord-298503-l60cdllh 236 11 IC IC NNP cord-298503-l60cdllh 236 12 with with IN cord-298503-l60cdllh 236 13 the the DT cord-298503-l60cdllh 236 14 endocytic endocytic JJ cord-298503-l60cdllh 236 15 recycling recycling NN cord-298503-l60cdllh 236 16 compartment compartment NN cord-298503-l60cdllh 236 17 ( ( -LRB- cord-298503-l60cdllh 236 18 ERC ERC NNP cord-298503-l60cdllh 236 19 ) ) -RRB- cord-298503-l60cdllh 236 20 , , , cord-298503-l60cdllh 236 21 its -PRON- PRP$ cord-298503-l60cdllh 236 22 ' ' `` cord-298503-l60cdllh 236 23 mirror mirror NN cord-298503-l60cdllh 236 24 compartment compartment NN cord-298503-l60cdllh 236 25 ' ' '' cord-298503-l60cdllh 236 26 next next RB cord-298503-l60cdllh 236 27 to to IN cord-298503-l60cdllh 236 28 the the DT cord-298503-l60cdllh 236 29 centrosome centrosome NN cord-298503-l60cdllh 236 30 , , , cord-298503-l60cdllh 236 31 it -PRON- PRP cord-298503-l60cdllh 236 32 has have VBZ cord-298503-l60cdllh 236 33 been be VBN cord-298503-l60cdllh 236 34 designated designate VBN cord-298503-l60cdllh 236 35 as as IN cord-298503-l60cdllh 236 36 the the DT cord-298503-l60cdllh 236 37 biosynthetic biosynthetic JJ cord-298503-l60cdllh 236 38 recycling recycling NN cord-298503-l60cdllh 236 39 compartment compartment NN cord-298503-l60cdllh 236 40 ( ( -LRB- cord-298503-l60cdllh 236 41 BRC BRC NNP cord-298503-l60cdllh 236 42 ; ; : cord-298503-l60cdllh 236 43 Saraste Saraste NNP cord-298503-l60cdllh 236 44 and and CC cord-298503-l60cdllh 236 45 Goud Goud NNP cord-298503-l60cdllh 236 46 , , , cord-298503-l60cdllh 236 47 2007 2007 CD cord-298503-l60cdllh 236 48 ; ; : cord-298503-l60cdllh 236 49 Marie Marie NNP cord-298503-l60cdllh 236 50 et et NNP cord-298503-l60cdllh 236 51 al al NNP cord-298503-l60cdllh 236 52 . . NNP cord-298503-l60cdllh 236 53 , , , cord-298503-l60cdllh 236 54 2009 2009 CD cord-298503-l60cdllh 236 55 ) ) -RRB- cord-298503-l60cdllh 236 56 . . . cord-298503-l60cdllh 237 1 Lumenal lumenal JJ cord-298503-l60cdllh 237 2 conditions condition NNS cord-298503-l60cdllh 237 3 : : : cord-298503-l60cdllh 237 4 Receptor receptor NN cord-298503-l60cdllh 237 5 - - HYPH cord-298503-l60cdllh 237 6 mediated mediate VBN cord-298503-l60cdllh 237 7 retrieval retrieval NN cord-298503-l60cdllh 237 8 of of IN cord-298503-l60cdllh 237 9 KDEL KDEL NNP cord-298503-l60cdllh 237 10 proteins protein NNS cord-298503-l60cdllh 237 11 from from IN cord-298503-l60cdllh 237 12 the the DT cord-298503-l60cdllh 237 13 IC IC NNP cord-298503-l60cdllh 237 14 requires require VBZ cord-298503-l60cdllh 237 15 that that IN cord-298503-l60cdllh 237 16 it -PRON- PRP cord-298503-l60cdllh 237 17 is be VBZ cord-298503-l60cdllh 237 18 discontinuous discontinuous JJ cord-298503-l60cdllh 237 19 with with IN cord-298503-l60cdllh 237 20 the the DT cord-298503-l60cdllh 237 21 ER ER NNP cord-298503-l60cdllh 237 22 and and CC cord-298503-l60cdllh 237 23 maintains maintain VBZ cord-298503-l60cdllh 237 24 special special JJ cord-298503-l60cdllh 237 25 lumenal lumenal JJ cord-298503-l60cdllh 237 26 conditions condition NNS cord-298503-l60cdllh 237 27 ( ( -LRB- cord-298503-l60cdllh 237 28 Pelham Pelham NNP cord-298503-l60cdllh 237 29 , , , cord-298503-l60cdllh 237 30 1989 1989 CD cord-298503-l60cdllh 237 31 ) ) -RRB- cord-298503-l60cdllh 237 32 . . . cord-298503-l60cdllh 238 1 The the DT cord-298503-l60cdllh 238 2 finding finding NN cord-298503-l60cdllh 238 3 of of IN cord-298503-l60cdllh 238 4 low low JJ cord-298503-l60cdllh 238 5 pH ph NN cord-298503-l60cdllh 238 6 - - HYPH cord-298503-l60cdllh 238 7 dependent dependent JJ cord-298503-l60cdllh 238 8 binding binding NN cord-298503-l60cdllh 238 9 of of IN cord-298503-l60cdllh 238 10 KDEL KDEL NNP cord-298503-l60cdllh 238 11 - - HYPH cord-298503-l60cdllh 238 12 ligands ligand NNS cord-298503-l60cdllh 238 13 to to IN cord-298503-l60cdllh 238 14 their -PRON- PRP$ cord-298503-l60cdllh 238 15 receptor receptor NN cord-298503-l60cdllh 238 16 in in IN cord-298503-l60cdllh 238 17 vitro vitro FW cord-298503-l60cdllh 238 18 suggested suggest VBD cord-298503-l60cdllh 238 19 the the DT cord-298503-l60cdllh 238 20 existence existence NN cord-298503-l60cdllh 238 21 of of IN cord-298503-l60cdllh 238 22 a a DT cord-298503-l60cdllh 238 23 pH ph NN cord-298503-l60cdllh 238 24 gradient gradient NN cord-298503-l60cdllh 238 25 between between IN cord-298503-l60cdllh 238 26 the the DT cord-298503-l60cdllh 238 27 ER ER NNP cord-298503-l60cdllh 238 28 and and CC cord-298503-l60cdllh 238 29 cis cis NNP cord-298503-l60cdllh 238 30 - - HYPH cord-298503-l60cdllh 238 31 Golgi Golgi NNP cord-298503-l60cdllh 239 1 ( ( -LRB- cord-298503-l60cdllh 239 2 Wilson Wilson NNP cord-298503-l60cdllh 239 3 et et NNP cord-298503-l60cdllh 239 4 al al NNP cord-298503-l60cdllh 239 5 . . NNP cord-298503-l60cdllh 239 6 , , , cord-298503-l60cdllh 239 7 1993 1993 CD cord-298503-l60cdllh 239 8 ) ) -RRB- cord-298503-l60cdllh 239 9 . . . cord-298503-l60cdllh 240 1 The the DT cord-298503-l60cdllh 240 2 pHsensitive pHsensitive NNP cord-298503-l60cdllh 240 3 interactions interaction NNS cord-298503-l60cdllh 240 4 of of IN cord-298503-l60cdllh 240 5 the the DT cord-298503-l60cdllh 240 6 low low JJ cord-298503-l60cdllh 240 7 density density NN cord-298503-l60cdllh 240 8 lipoprotein lipoprotein NN cord-298503-l60cdllh 240 9 ( ( -LRB- cord-298503-l60cdllh 240 10 LDL)receptor ldl)receptor NN cord-298503-l60cdllh 240 11 - - HYPH cord-298503-l60cdllh 240 12 related relate VBN cord-298503-l60cdllh 240 13 protein protein NN cord-298503-l60cdllh 240 14 ( ( -LRB- cord-298503-l60cdllh 240 15 LRP LRP NNP cord-298503-l60cdllh 240 16 ) ) -RRB- cord-298503-l60cdllh 240 17 and and CC cord-298503-l60cdllh 240 18 procollagen procollagen VB cord-298503-l60cdllh 240 19 with with IN cord-298503-l60cdllh 240 20 the the DT cord-298503-l60cdllh 240 21 chaperones chaperone NNS cord-298503-l60cdllh 240 22 RAP rap NN cord-298503-l60cdllh 240 23 and and CC cord-298503-l60cdllh 240 24 Hsp47 Hsp47 NNP cord-298503-l60cdllh 240 25 , , , cord-298503-l60cdllh 240 26 respectively respectively RB cord-298503-l60cdllh 240 27 ( ( -LRB- cord-298503-l60cdllh 240 28 Bu Bu NNP cord-298503-l60cdllh 240 29 et et FW cord-298503-l60cdllh 240 30 al al NNP cord-298503-l60cdllh 240 31 . . NNP cord-298503-l60cdllh 240 32 , , , cord-298503-l60cdllh 240 33 1995 1995 CD cord-298503-l60cdllh 240 34 ; ; : cord-298503-l60cdllh 240 35 Satoh Satoh NNP cord-298503-l60cdllh 240 36 et et FW cord-298503-l60cdllh 240 37 al al NNP cord-298503-l60cdllh 240 38 . . NNP cord-298503-l60cdllh 240 39 , , , cord-298503-l60cdllh 240 40 1996 1996 CD cord-298503-l60cdllh 240 41 ) ) -RRB- cord-298503-l60cdllh 240 42 , , , cord-298503-l60cdllh 240 43 and and CC cord-298503-l60cdllh 240 44 partial partial JJ cord-298503-l60cdllh 240 45 co co NN cord-298503-l60cdllh 240 46 - - NN cord-298503-l60cdllh 240 47 localization localization NN cord-298503-l60cdllh 240 48 of of IN cord-298503-l60cdllh 240 49 DAMP damp NN cord-298503-l60cdllh 240 50 ( ( -LRB- cord-298503-l60cdllh 240 51 a a DT cord-298503-l60cdllh 240 52 marker marker NN cord-298503-l60cdllh 240 53 for for IN cord-298503-l60cdllh 240 54 acidic acidic JJ cord-298503-l60cdllh 240 55 compartments compartment NNS cord-298503-l60cdllh 240 56 ) ) -RRB- cord-298503-l60cdllh 240 57 and and CC cord-298503-l60cdllh 240 58 p58 p58 NNP cord-298503-l60cdllh 240 59 / / SYM cord-298503-l60cdllh 240 60 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 240 61 in in IN cord-298503-l60cdllh 240 62 central central JJ cord-298503-l60cdllh 240 63 IC IC NNP cord-298503-l60cdllh 240 64 elements element NNS cord-298503-l60cdllh 241 1 ( ( -LRB- cord-298503-l60cdllh 241 2 Palokangas Palokangas NNP cord-298503-l60cdllh 241 3 et et NNP cord-298503-l60cdllh 241 4 al al NNP cord-298503-l60cdllh 241 5 . . NNP cord-298503-l60cdllh 241 6 , , , cord-298503-l60cdllh 241 7 1998 1998 CD cord-298503-l60cdllh 241 8 ) ) -RRB- cord-298503-l60cdllh 241 9 , , , cord-298503-l60cdllh 241 10 are be VBP cord-298503-l60cdllh 241 11 in in IN cord-298503-l60cdllh 241 12 accordance accordance NN cord-298503-l60cdllh 241 13 with with IN cord-298503-l60cdllh 241 14 this this DT cord-298503-l60cdllh 241 15 idea idea NN cord-298503-l60cdllh 241 16 . . . cord-298503-l60cdllh 242 1 The the DT cord-298503-l60cdllh 242 2 pH ph NN cord-298503-l60cdllh 242 3 of of IN cord-298503-l60cdllh 242 4 the the DT cord-298503-l60cdllh 242 5 ER ER NNP cord-298503-l60cdllh 242 6 and and CC cord-298503-l60cdllh 242 7 cis cis NNP cord-298503-l60cdllh 242 8 - - HYPH cord-298503-l60cdllh 242 9 Golgi Golgi NNP cord-298503-l60cdllh 242 10 has have VBZ cord-298503-l60cdllh 242 11 been be VBN cord-298503-l60cdllh 242 12 estimated estimate VBN cord-298503-l60cdllh 242 13 to to TO cord-298503-l60cdllh 242 14 be be VB cord-298503-l60cdllh 242 15 about about RB cord-298503-l60cdllh 242 16 7.2 7.2 CD cord-298503-l60cdllh 242 17 and and CC cord-298503-l60cdllh 242 18 6.5 6.5 CD cord-298503-l60cdllh 242 19 - - SYM cord-298503-l60cdllh 242 20 6.7 6.7 CD cord-298503-l60cdllh 242 21 , , , cord-298503-l60cdllh 242 22 respectively respectively RB cord-298503-l60cdllh 242 23 ( ( -LRB- cord-298503-l60cdllh 242 24 Paroutis Paroutis NNP cord-298503-l60cdllh 242 25 et et FW cord-298503-l60cdllh 242 26 al al NNP cord-298503-l60cdllh 242 27 . . . cord-298503-l60cdllh 243 1 , , , cord-298503-l60cdllh 243 2 2004 2004 CD cord-298503-l60cdllh 243 3 ; ; : cord-298503-l60cdllh 243 4 Vavassori Vavassori NNP cord-298503-l60cdllh 243 5 et et FW cord-298503-l60cdllh 243 6 al al NNP cord-298503-l60cdllh 243 7 . . NNP cord-298503-l60cdllh 243 8 , , , cord-298503-l60cdllh 243 9 2013 2013 CD cord-298503-l60cdllh 243 10 ) ) -RRB- cord-298503-l60cdllh 243 11 . . . cord-298503-l60cdllh 244 1 Although although IN cord-298503-l60cdllh 244 2 the the DT cord-298503-l60cdllh 244 3 effect effect NN cord-298503-l60cdllh 244 4 pH ph NN cord-298503-l60cdllh 244 5 on on IN cord-298503-l60cdllh 244 6 the the DT cord-298503-l60cdllh 244 7 binding binding NN cord-298503-l60cdllh 244 8 of of IN cord-298503-l60cdllh 244 9 mannose mannose NN cord-298503-l60cdllh 244 10 - - HYPH cord-298503-l60cdllh 244 11 containing contain VBG cord-298503-l60cdllh 244 12 cargo cargo NN cord-298503-l60cdllh 244 13 to to IN cord-298503-l60cdllh 244 14 p58 p58 NNP cord-298503-l60cdllh 244 15 / / SYM cord-298503-l60cdllh 244 16 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 244 17 / / SYM cord-298503-l60cdllh 244 18 LMAN1 LMAN1 NNP cord-298503-l60cdllh 244 19 remains remain VBZ cord-298503-l60cdllh 244 20 unclear unclear JJ cord-298503-l60cdllh 244 21 , , , cord-298503-l60cdllh 244 22 it -PRON- PRP cord-298503-l60cdllh 244 23 appears appear VBZ cord-298503-l60cdllh 244 24 that that IN cord-298503-l60cdllh 244 25 cargo cargo NN cord-298503-l60cdllh 244 26 release release NN cord-298503-l60cdllh 244 27 is be VBZ cord-298503-l60cdllh 244 28 caused cause VBN cord-298503-l60cdllh 244 29 by by IN cord-298503-l60cdllh 244 30 a a DT cord-298503-l60cdllh 244 31 drop drop NN cord-298503-l60cdllh 244 32 in in IN cord-298503-l60cdllh 244 33 free free JJ cord-298503-l60cdllh 244 34 calcium calcium NN cord-298503-l60cdllh 244 35 concentration concentration NN cord-298503-l60cdllh 244 36 between between IN cord-298503-l60cdllh 244 37 the the DT cord-298503-l60cdllh 244 38 ER ER NNP cord-298503-l60cdllh 244 39 and and CC cord-298503-l60cdllh 244 40 IC IC NNP cord-298503-l60cdllh 244 41 lumen lumen NNP cord-298503-l60cdllh 245 1 ( ( -LRB- cord-298503-l60cdllh 245 2 Appenzeller Appenzeller NNP cord-298503-l60cdllh 245 3 - - HYPH cord-298503-l60cdllh 245 4 Herzog Herzog NNP cord-298503-l60cdllh 245 5 et et NNP cord-298503-l60cdllh 245 6 al al NNP cord-298503-l60cdllh 245 7 . . NNP cord-298503-l60cdllh 245 8 , , , cord-298503-l60cdllh 245 9 2004 2004 CD cord-298503-l60cdllh 245 10 ; ; : cord-298503-l60cdllh 245 11 Bentley Bentley NNP cord-298503-l60cdllh 245 12 et et NNP cord-298503-l60cdllh 245 13 al al NNP cord-298503-l60cdllh 245 14 . . NNP cord-298503-l60cdllh 245 15 , , , cord-298503-l60cdllh 245 16 2010 2010 CD cord-298503-l60cdllh 245 17 ; ; : cord-298503-l60cdllh 245 18 . . . cord-298503-l60cdllh 246 1 On on IN cord-298503-l60cdllh 246 2 the the DT cord-298503-l60cdllh 246 3 other other JJ cord-298503-l60cdllh 246 4 hand hand NN cord-298503-l60cdllh 246 5 , , , cord-298503-l60cdllh 246 6 the the DT cord-298503-l60cdllh 246 7 depletion depletion NN cord-298503-l60cdllh 246 8 of of IN cord-298503-l60cdllh 246 9 lumenal lumenal JJ cord-298503-l60cdllh 246 10 calcium calcium NN cord-298503-l60cdllh 246 11 stores store NNS cord-298503-l60cdllh 246 12 affects affect VBZ cord-298503-l60cdllh 246 13 the the DT cord-298503-l60cdllh 246 14 morphology morphology NN cord-298503-l60cdllh 246 15 of of IN cord-298503-l60cdllh 246 16 the the DT cord-298503-l60cdllh 246 17 IC IC NNP cord-298503-l60cdllh 246 18 and and CC cord-298503-l60cdllh 246 19 the the DT cord-298503-l60cdllh 246 20 recycling recycling NN cord-298503-l60cdllh 246 21 of of IN cord-298503-l60cdllh 246 22 cargo cargo NN cord-298503-l60cdllh 246 23 receptors receptor NNS cord-298503-l60cdllh 246 24 at at IN cord-298503-l60cdllh 246 25 the the DT cord-298503-l60cdllh 246 26 ER ER NNP cord-298503-l60cdllh 246 27 - - HYPH cord-298503-l60cdllh 246 28 Golgi Golgi NNP cord-298503-l60cdllh 246 29 boundary boundary NN cord-298503-l60cdllh 246 30 , , , cord-298503-l60cdllh 246 31 and and CC cord-298503-l60cdllh 246 32 the the DT cord-298503-l60cdllh 246 33 IC IC NNP cord-298503-l60cdllh 246 34 has have VBZ cord-298503-l60cdllh 246 35 been be VBN cord-298503-l60cdllh 246 36 reported report VBN cord-298503-l60cdllh 246 37 to to TO cord-298503-l60cdllh 246 38 contain contain VB cord-298503-l60cdllh 246 39 the the DT cord-298503-l60cdllh 246 40 calcium calcium NN cord-298503-l60cdllh 246 41 - - HYPH cord-298503-l60cdllh 246 42 ATPase atpase NN cord-298503-l60cdllh 246 43 SERCA SERCA NNP cord-298503-l60cdllh 246 44 , , , cord-298503-l60cdllh 246 45 as as RB cord-298503-l60cdllh 246 46 well well RB cord-298503-l60cdllh 246 47 as as IN cord-298503-l60cdllh 246 48 the the DT cord-298503-l60cdllh 246 49 calciumbinding calciumbinding NN cord-298503-l60cdllh 246 50 proteins protein NNS cord-298503-l60cdllh 246 51 BiP BiP NNP cord-298503-l60cdllh 246 52 , , , cord-298503-l60cdllh 246 53 GRP94 GRP94 NNP cord-298503-l60cdllh 246 54 , , , cord-298503-l60cdllh 246 55 CR CR NNP cord-298503-l60cdllh 246 56 , , , cord-298503-l60cdllh 246 57 and and CC cord-298503-l60cdllh 246 58 CALNUC CALNUC NNP cord-298503-l60cdllh 246 59 ( ( -LRB- cord-298503-l60cdllh 246 60 Ying Ying NNP cord-298503-l60cdllh 246 61 et et FW cord-298503-l60cdllh 246 62 al al NNP cord-298503-l60cdllh 246 63 . . . cord-298503-l60cdllh 247 1 , , , cord-298503-l60cdllh 247 2 2002 2002 CD cord-298503-l60cdllh 247 3 ; ; : cord-298503-l60cdllh 247 4 Breuza Breuza NNP cord-298503-l60cdllh 247 5 et et NNP cord-298503-l60cdllh 247 6 al al NNP cord-298503-l60cdllh 247 7 . . NNP cord-298503-l60cdllh 247 8 , , , cord-298503-l60cdllh 247 9 2004 2004 CD cord-298503-l60cdllh 247 10 ; ; : cord-298503-l60cdllh 248 1 Howe Howe NNP cord-298503-l60cdllh 248 2 et et NNP cord-298503-l60cdllh 248 3 al al NNP cord-298503-l60cdllh 248 4 . . NNP cord-298503-l60cdllh 248 5 , , , cord-298503-l60cdllh 248 6 2009 2009 CD cord-298503-l60cdllh 248 7 ; ; : cord-298503-l60cdllh 248 8 Bentley Bentley NNP cord-298503-l60cdllh 248 9 et et NNP cord-298503-l60cdllh 248 10 al al NNP cord-298503-l60cdllh 248 11 . . NNP cord-298503-l60cdllh 248 12 , , , cord-298503-l60cdllh 248 13 2010 2010 CD cord-298503-l60cdllh 248 14 ) ) -RRB- cord-298503-l60cdllh 248 15 , , , cord-298503-l60cdllh 248 16 suggesting suggest VBG cord-298503-l60cdllh 248 17 its -PRON- PRP$ cord-298503-l60cdllh 248 18 role role NN cord-298503-l60cdllh 248 19 in in IN cord-298503-l60cdllh 248 20 intracellular intracellular JJ cord-298503-l60cdllh 248 21 calcium calcium NN cord-298503-l60cdllh 248 22 storage storage NN cord-298503-l60cdllh 248 23 . . . cord-298503-l60cdllh 249 1 Role role NN cord-298503-l60cdllh 249 2 of of IN cord-298503-l60cdllh 249 3 COPI COPI NNP cord-298503-l60cdllh 249 4 coats coat NNS cord-298503-l60cdllh 249 5 : : : cord-298503-l60cdllh 249 6 There there EX cord-298503-l60cdllh 249 7 are be VBP cord-298503-l60cdllh 249 8 at at RB cord-298503-l60cdllh 249 9 least least RBS cord-298503-l60cdllh 249 10 three three CD cord-298503-l60cdllh 249 11 subtypes subtype NNS cord-298503-l60cdllh 249 12 of of IN cord-298503-l60cdllh 249 13 COPI COPI NNP cord-298503-l60cdllh 249 14 coats coat NNS cord-298503-l60cdllh 249 15 ( ( -LRB- cord-298503-l60cdllh 249 16 Beck Beck NNP cord-298503-l60cdllh 249 17 et et NNP cord-298503-l60cdllh 249 18 al al NNP cord-298503-l60cdllh 249 19 . . NNP cord-298503-l60cdllh 249 20 , , , cord-298503-l60cdllh 249 21 2009 2009 CD cord-298503-l60cdllh 249 22 ) ) -RRB- cord-298503-l60cdllh 249 23 , , , cord-298503-l60cdllh 249 24 and and CC cord-298503-l60cdllh 249 25 four four CD cord-298503-l60cdllh 249 26 Arf Arf NNP cord-298503-l60cdllh 249 27 GTPases gtpase NNS cord-298503-l60cdllh 249 28 that that WDT cord-298503-l60cdllh 249 29 regulate regulate VBP cord-298503-l60cdllh 249 30 their -PRON- PRP$ cord-298503-l60cdllh 249 31 membrane membrane NN cord-298503-l60cdllh 249 32 binding binding NN cord-298503-l60cdllh 249 33 ( ( -LRB- cord-298503-l60cdllh 250 1 Popoff Popoff NNP cord-298503-l60cdllh 250 2 et et NNP cord-298503-l60cdllh 250 3 al al NNP cord-298503-l60cdllh 250 4 . . NNP cord-298503-l60cdllh 250 5 , , , cord-298503-l60cdllh 250 6 2011 2011 CD cord-298503-l60cdllh 250 7 ) ) -RRB- cord-298503-l60cdllh 250 8 . . . cord-298503-l60cdllh 251 1 Three three CD cord-298503-l60cdllh 251 2 Arfs Arfs NNP cord-298503-l60cdllh 251 3 appear appear VBP cord-298503-l60cdllh 251 4 to to TO cord-298503-l60cdllh 251 5 act act VB cord-298503-l60cdllh 251 6 at at IN cord-298503-l60cdllh 251 7 the the DT cord-298503-l60cdllh 251 8 ER ER NNP cord-298503-l60cdllh 251 9 - - HYPH cord-298503-l60cdllh 251 10 Golgi Golgi NNP cord-298503-l60cdllh 251 11 boundary boundary NN cord-298503-l60cdllh 251 12 and and CC cord-298503-l60cdllh 251 13 two two CD cord-298503-l60cdllh 251 14 of of IN cord-298503-l60cdllh 251 15 these these DT cord-298503-l60cdllh 251 16 associate associate NN cord-298503-l60cdllh 251 17 with with IN cord-298503-l60cdllh 251 18 membranes membrane NNS cord-298503-l60cdllh 251 19 in in IN cord-298503-l60cdllh 251 20 a a DT cord-298503-l60cdllh 251 21 BFA BFA NNP cord-298503-l60cdllh 251 22 - - HYPH cord-298503-l60cdllh 251 23 resistant resistant JJ cord-298503-l60cdllh 251 24 manner manner NN cord-298503-l60cdllh 252 1 ( ( -LRB- cord-298503-l60cdllh 252 2 Volpicelli Volpicelli NNP cord-298503-l60cdllh 252 3 - - HYPH cord-298503-l60cdllh 252 4 Daley Daley NNP cord-298503-l60cdllh 252 5 et et NNP cord-298503-l60cdllh 252 6 al al NNP cord-298503-l60cdllh 252 7 . . . cord-298503-l60cdllh 253 1 , , , cord-298503-l60cdllh 253 2 2005 2005 CD cord-298503-l60cdllh 253 3 ; ; : cord-298503-l60cdllh 253 4 Chun Chun NNP cord-298503-l60cdllh 253 5 et et NNP cord-298503-l60cdllh 253 6 al al NNP cord-298503-l60cdllh 253 7 . . NNP cord-298503-l60cdllh 253 8 , , , cord-298503-l60cdllh 253 9 2008 2008 CD cord-298503-l60cdllh 253 10 ; ; . cord-298503-l60cdllh 254 1 Duijsings Duijsings NNP cord-298503-l60cdllh 254 2 et et NNP cord-298503-l60cdllh 254 3 al al NNP cord-298503-l60cdllh 254 4 . . . cord-298503-l60cdllh 255 1 , , , cord-298503-l60cdllh 255 2 2009 2009 CD cord-298503-l60cdllh 255 3 ; ; : cord-298503-l60cdllh 255 4 Ben Ben NNP cord-298503-l60cdllh 255 5 - - HYPH cord-298503-l60cdllh 255 6 Tekaya Tekaya NNP cord-298503-l60cdllh 255 7 et et NNP cord-298503-l60cdllh 255 8 al al NNP cord-298503-l60cdllh 255 9 . . NNP cord-298503-l60cdllh 255 10 , , , cord-298503-l60cdllh 255 11 2010 2010 CD cord-298503-l60cdllh 255 12 ; ; : cord-298503-l60cdllh 255 13 Hamlin Hamlin NNP cord-298503-l60cdllh 255 14 et et NNP cord-298503-l60cdllh 255 15 al al NNP cord-298503-l60cdllh 255 16 . . NNP cord-298503-l60cdllh 255 17 , , , cord-298503-l60cdllh 255 18 2014 2014 CD cord-298503-l60cdllh 255 19 ) ) -RRB- cord-298503-l60cdllh 255 20 , , . cord-298503-l60cdllh 256 1 suggesting suggest VBG cord-298503-l60cdllh 256 2 that that IN cord-298503-l60cdllh 256 3 different different JJ cord-298503-l60cdllh 256 4 types type NNS cord-298503-l60cdllh 256 5 of of IN cord-298503-l60cdllh 256 6 COPI COPI NNP cord-298503-l60cdllh 256 7 vesicles vesicle NNS cord-298503-l60cdllh 256 8 mediate mediate VBP cord-298503-l60cdllh 256 9 two two CD cord-298503-l60cdllh 256 10 - - HYPH cord-298503-l60cdllh 256 11 way way NN cord-298503-l60cdllh 256 12 trafficking trafficking NN cord-298503-l60cdllh 256 13 at at IN cord-298503-l60cdllh 256 14 the the DT cord-298503-l60cdllh 256 15 level level NN cord-298503-l60cdllh 256 16 of of IN cord-298503-l60cdllh 256 17 the the DT cord-298503-l60cdllh 256 18 IC IC NNP cord-298503-l60cdllh 256 19 . . . cord-298503-l60cdllh 257 1 The the DT cord-298503-l60cdllh 257 2 role role NN cord-298503-l60cdllh 257 3 of of IN cord-298503-l60cdllh 257 4 COPI COPI NNP cord-298503-l60cdllh 257 5 in in IN cord-298503-l60cdllh 257 6 anterograde anterograde JJ cord-298503-l60cdllh 257 7 transport transport NN cord-298503-l60cdllh 257 8 has have VBZ cord-298503-l60cdllh 257 9 been be VBN cord-298503-l60cdllh 257 10 considered consider VBN cord-298503-l60cdllh 257 11 for for IN cord-298503-l60cdllh 257 12 some some DT cord-298503-l60cdllh 257 13 time time NN cord-298503-l60cdllh 258 1 ( ( -LRB- cord-298503-l60cdllh 258 2 Hosobuchi Hosobuchi NNP cord-298503-l60cdllh 258 3 et et NNP cord-298503-l60cdllh 258 4 al al NNP cord-298503-l60cdllh 258 5 . . . cord-298503-l60cdllh 259 1 , , , cord-298503-l60cdllh 259 2 1992 1992 CD cord-298503-l60cdllh 259 3 ; ; : cord-298503-l60cdllh 259 4 Pepperkok Pepperkok NNP cord-298503-l60cdllh 259 5 et et NNP cord-298503-l60cdllh 259 6 al al NNP cord-298503-l60cdllh 259 7 . . . cord-298503-l60cdllh 260 1 , , , cord-298503-l60cdllh 260 2 1993 1993 CD cord-298503-l60cdllh 260 3 ; ; : cord-298503-l60cdllh 260 4 Peter Peter NNP cord-298503-l60cdllh 260 5 et et NNP cord-298503-l60cdllh 260 6 al al NNP cord-298503-l60cdllh 260 7 . . NNP cord-298503-l60cdllh 260 8 , , , cord-298503-l60cdllh 260 9 1993 1993 CD cord-298503-l60cdllh 260 10 ; ; : cord-298503-l60cdllh 260 11 Orci Orci NNP cord-298503-l60cdllh 260 12 et et NNP cord-298503-l60cdllh 260 13 al al NNP cord-298503-l60cdllh 260 14 . . NNP cord-298503-l60cdllh 260 15 , , , cord-298503-l60cdllh 260 16 1997 1997 CD cord-298503-l60cdllh 260 17 ; ; . cord-298503-l60cdllh 261 1 Malsam Malsam NNP cord-298503-l60cdllh 261 2 et et NNP cord-298503-l60cdllh 261 3 al al NNP cord-298503-l60cdllh 261 4 . . NNP cord-298503-l60cdllh 261 5 , , , cord-298503-l60cdllh 261 6 2005 2005 CD cord-298503-l60cdllh 261 7 ) ) -RRB- cord-298503-l60cdllh 261 8 . . . cord-298503-l60cdllh 262 1 In in IN cord-298503-l60cdllh 262 2 addition addition NN cord-298503-l60cdllh 262 3 , , , cord-298503-l60cdllh 262 4 although although IN cord-298503-l60cdllh 262 5 both both DT cord-298503-l60cdllh 262 6 p58 p58 NNP cord-298503-l60cdllh 262 7 / / SYM cord-298503-l60cdllh 262 8 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 262 9 and and CC cord-298503-l60cdllh 262 10 KDEL KDEL NNP cord-298503-l60cdllh 262 11 - - HYPH cord-298503-l60cdllh 262 12 receptor receptor NN cord-298503-l60cdllh 262 13 employ employ VB cord-298503-l60cdllh 262 14 COPI COPI NNP cord-298503-l60cdllh 262 15 vesicles vesicle NNS cord-298503-l60cdllh 262 16 in in IN cord-298503-l60cdllh 262 17 their -PRON- PRP$ cord-298503-l60cdllh 262 18 recycling recycling NN cord-298503-l60cdllh 262 19 , , , cord-298503-l60cdllh 262 20 their -PRON- PRP$ cord-298503-l60cdllh 262 21 transport transport NN cord-298503-l60cdllh 262 22 itineraries itinerary NNS cord-298503-l60cdllh 262 23 differ differ VBP cord-298503-l60cdllh 262 24 ( ( -LRB- cord-298503-l60cdllh 262 25 Tang Tang NNP cord-298503-l60cdllh 262 26 et et FW cord-298503-l60cdllh 262 27 al al NNP cord-298503-l60cdllh 262 28 . . NNP cord-298503-l60cdllh 262 29 , , , cord-298503-l60cdllh 262 30 1995a 1995a CD cord-298503-l60cdllh 262 31 ; ; : cord-298503-l60cdllh 262 32 Marie Marie NNP cord-298503-l60cdllh 262 33 et et NNP cord-298503-l60cdllh 262 34 al al NNP cord-298503-l60cdllh 262 35 . . NNP cord-298503-l60cdllh 262 36 , , , cord-298503-l60cdllh 262 37 2009 2009 CD cord-298503-l60cdllh 262 38 Marie Marie NNP cord-298503-l60cdllh 262 39 et et NNP cord-298503-l60cdllh 262 40 al al NNP cord-298503-l60cdllh 262 41 . . NNP cord-298503-l60cdllh 262 42 , , , cord-298503-l60cdllh 262 43 , , , cord-298503-l60cdllh 262 44 2012 2012 CD cord-298503-l60cdllh 262 45 . . . cord-298503-l60cdllh 263 1 In in IN cord-298503-l60cdllh 263 2 addition addition NN cord-298503-l60cdllh 263 3 to to IN cord-298503-l60cdllh 263 4 acting act VBG cord-298503-l60cdllh 263 5 in in IN cord-298503-l60cdllh 263 6 vesicle vesicle NN cord-298503-l60cdllh 263 7 budding bud VBG cord-298503-l60cdllh 263 8 the the DT cord-298503-l60cdllh 263 9 COPI COPI NNP cord-298503-l60cdllh 263 10 coats coat NNS cord-298503-l60cdllh 263 11 may may MD cord-298503-l60cdllh 263 12 form form VB cord-298503-l60cdllh 263 13 membrane membrane NN cord-298503-l60cdllh 263 14 domains domain NNS cord-298503-l60cdllh 263 15 ( ( -LRB- cord-298503-l60cdllh 263 16 Presley Presley NNP cord-298503-l60cdllh 263 17 et et NNP cord-298503-l60cdllh 263 18 al al NNP cord-298503-l60cdllh 263 19 . . NNP cord-298503-l60cdllh 263 20 , , , cord-298503-l60cdllh 263 21 2002 2002 CD cord-298503-l60cdllh 263 22 ) ) -RRB- cord-298503-l60cdllh 263 23 . . . cord-298503-l60cdllh 264 1 Golgi Golgi NNP cord-298503-l60cdllh 264 2 bypass bypass NN cord-298503-l60cdllh 264 3 : : : cord-298503-l60cdllh 265 1 Besides besides IN cord-298503-l60cdllh 265 2 mediating mediate VBG cord-298503-l60cdllh 265 3 bidirectional bidirectional JJ cord-298503-l60cdllh 265 4 ER ER NNP cord-298503-l60cdllh 265 5 - - HYPH cord-298503-l60cdllh 265 6 Golgi golgi NN cord-298503-l60cdllh 265 7 trafficking trafficking NN cord-298503-l60cdllh 265 8 , , , cord-298503-l60cdllh 265 9 the the DT cord-298503-l60cdllh 265 10 IC IC NNP cord-298503-l60cdllh 265 11 has have VBZ cord-298503-l60cdllh 265 12 been be VBN cord-298503-l60cdllh 265 13 suggested suggest VBN cord-298503-l60cdllh 265 14 to to TO cord-298503-l60cdllh 265 15 be be VB cord-298503-l60cdllh 265 16 involved involve VBN cord-298503-l60cdllh 265 17 in in IN cord-298503-l60cdllh 265 18 Golgiindependent Golgiindependent NNP cord-298503-l60cdllh 265 19 pathway(s pathway(s NNP cord-298503-l60cdllh 265 20 ) ) -RRB- cord-298503-l60cdllh 266 1 ( ( -LRB- cord-298503-l60cdllh 266 2 Marie Marie NNP cord-298503-l60cdllh 266 3 et et NNP cord-298503-l60cdllh 266 4 al al NNP cord-298503-l60cdllh 266 5 . . NNP cord-298503-l60cdllh 266 6 , , , cord-298503-l60cdllh 266 7 2008 2008 CD cord-298503-l60cdllh 266 8 ; ; : cord-298503-l60cdllh 266 9 Saraste Saraste NNP cord-298503-l60cdllh 266 10 et et NNP cord-298503-l60cdllh 266 11 al al NNP cord-298503-l60cdllh 266 12 . . NNP cord-298503-l60cdllh 266 13 , , , cord-298503-l60cdllh 266 14 2009 2009 CD cord-298503-l60cdllh 266 15 ) ) -RRB- cord-298503-l60cdllh 266 16 . . . cord-298503-l60cdllh 267 1 The the DT cord-298503-l60cdllh 267 2 route route NN cord-298503-l60cdllh 267 3 between between IN cord-298503-l60cdllh 267 4 the the DT cord-298503-l60cdllh 267 5 IC IC NNP cord-298503-l60cdllh 267 6 and and CC cord-298503-l60cdllh 267 7 the the DT cord-298503-l60cdllh 267 8 leading leading JJ cord-298503-l60cdllh 267 9 edge edge NN cord-298503-l60cdllh 267 10 or or CC cord-298503-l60cdllh 267 11 growth growth NN cord-298503-l60cdllh 267 12 cone cone NN cord-298503-l60cdllh 267 13 of of IN cord-298503-l60cdllh 267 14 motile motile JJ cord-298503-l60cdllh 267 15 fibroblasts fibroblast NNS cord-298503-l60cdllh 267 16 or or CC cord-298503-l60cdllh 267 17 neurons neuron NNS cord-298503-l60cdllh 267 18 , , , cord-298503-l60cdllh 267 19 respectively respectively RB cord-298503-l60cdllh 267 20 ( ( -LRB- cord-298503-l60cdllh 267 21 Figures figure NNS cord-298503-l60cdllh 267 22 5 5 CD cord-298503-l60cdllh 267 23 and and CC cord-298503-l60cdllh 267 24 6 6 CD cord-298503-l60cdllh 267 25 ) ) -RRB- cord-298503-l60cdllh 267 26 , , , cord-298503-l60cdllh 267 27 could could MD cord-298503-l60cdllh 267 28 participate participate VB cord-298503-l60cdllh 267 29 in in IN cord-298503-l60cdllh 267 30 cholesterol cholesterol NN cord-298503-l60cdllh 267 31 and and CC cord-298503-l60cdllh 267 32 integrin integrin VB cord-298503-l60cdllh 267 33 trafficking trafficking NN cord-298503-l60cdllh 267 34 ( ( -LRB- cord-298503-l60cdllh 267 35 Urbani Urbani NNP cord-298503-l60cdllh 267 36 and and CC cord-298503-l60cdllh 267 37 Simoni Simoni NNP cord-298503-l60cdllh 267 38 , , , cord-298503-l60cdllh 267 39 1990 1990 CD cord-298503-l60cdllh 267 40 ; ; : cord-298503-l60cdllh 267 41 Sannerud Sannerud NNP cord-298503-l60cdllh 267 42 et et NNP cord-298503-l60cdllh 267 43 al al NNP cord-298503-l60cdllh 267 44 . . NNP cord-298503-l60cdllh 267 45 , , , cord-298503-l60cdllh 267 46 2006 2006 CD cord-298503-l60cdllh 267 47 ; ; . cord-298503-l60cdllh 268 1 Wang Wang NNP cord-298503-l60cdllh 268 2 et et NNP cord-298503-l60cdllh 268 3 al al NNP cord-298503-l60cdllh 268 4 . . NNP cord-298503-l60cdllh 268 5 , , , cord-298503-l60cdllh 268 6 2010 2010 CD cord-298503-l60cdllh 268 7 ) ) -RRB- cord-298503-l60cdllh 268 8 or or CC cord-298503-l60cdllh 268 9 correspond correspond VB cord-298503-l60cdllh 268 10 to to IN cord-298503-l60cdllh 268 11 the the DT cord-298503-l60cdllh 268 12 BFA BFA NNP cord-298503-l60cdllh 268 13 - - HYPH cord-298503-l60cdllh 268 14 resistant resistant JJ cord-298503-l60cdllh 268 15 ER ER NNP cord-298503-l60cdllh 268 16 - - HYPH cord-298503-l60cdllh 268 17 IC IC NNP cord-298503-l60cdllh 268 18 - - HYPH cord-298503-l60cdllh 268 19 PM PM NNP cord-298503-l60cdllh 268 20 route route NN cord-298503-l60cdllh 268 21 that that WDT cord-298503-l60cdllh 268 22 supports support VBZ cord-298503-l60cdllh 268 23 phagocytosis phagocytosis NN cord-298503-l60cdllh 268 24 ( ( -LRB- cord-298503-l60cdllh 268 25 Becker Becker NNP cord-298503-l60cdllh 268 26 et et NNP cord-298503-l60cdllh 268 27 al al NNP cord-298503-l60cdllh 268 28 . . NNP cord-298503-l60cdllh 268 29 , , , cord-298503-l60cdllh 268 30 2005 2005 CD cord-298503-l60cdllh 268 31 ; ; : cord-298503-l60cdllh 269 1 Saraste Saraste NNP cord-298503-l60cdllh 269 2 and and CC cord-298503-l60cdllh 269 3 Goud Goud NNP cord-298503-l60cdllh 269 4 , , , cord-298503-l60cdllh 269 5 2007 2007 CD cord-298503-l60cdllh 269 6 ; ; : cord-298503-l60cdllh 269 7 see see VB cord-298503-l60cdllh 269 8 below below RB cord-298503-l60cdllh 269 9 ) ) -RRB- cord-298503-l60cdllh 269 10 . . . cord-298503-l60cdllh 270 1 Direct direct JJ cord-298503-l60cdllh 270 2 pericentrosomal pericentrosomal JJ cord-298503-l60cdllh 270 3 communication communication NN cord-298503-l60cdllh 270 4 between between IN cord-298503-l60cdllh 270 5 the the DT cord-298503-l60cdllh 270 6 IC IC NNP cord-298503-l60cdllh 270 7 and and CC cord-298503-l60cdllh 270 8 the the DT cord-298503-l60cdllh 270 9 endosomal endosomal NNP cord-298503-l60cdllh 270 10 system system NN cord-298503-l60cdllh 270 11 seems seem VBZ cord-298503-l60cdllh 270 12 to to TO cord-298503-l60cdllh 270 13 be be VB cord-298503-l60cdllh 270 14 used use VBN cord-298503-l60cdllh 270 15 by by IN cord-298503-l60cdllh 270 16 the the DT cord-298503-l60cdllh 270 17 cystic cystic JJ cord-298503-l60cdllh 270 18 fibrosis fibrosis NN cord-298503-l60cdllh 270 19 transmembrane transmembrane NNP cord-298503-l60cdllh 270 20 conductance conductance NN cord-298503-l60cdllh 270 21 regulator regulator NN cord-298503-l60cdllh 270 22 ( ( -LRB- cord-298503-l60cdllh 270 23 CFTR CFTR NNP cord-298503-l60cdllh 270 24 ) ) -RRB- cord-298503-l60cdllh 270 25 during during IN cord-298503-l60cdllh 270 26 its -PRON- PRP$ cord-298503-l60cdllh 270 27 Golgi Golgi NNP cord-298503-l60cdllh 270 28 - - HYPH cord-298503-l60cdllh 270 29 independent independent JJ cord-298503-l60cdllh 270 30 transport transport NN cord-298503-l60cdllh 270 31 to to IN cord-298503-l60cdllh 270 32 the the DT cord-298503-l60cdllh 270 33 cell cell NN cord-298503-l60cdllh 270 34 surface surface NN cord-298503-l60cdllh 271 1 ( ( -LRB- cord-298503-l60cdllh 271 2 Yoo Yoo NNP cord-298503-l60cdllh 271 3 et et NNP cord-298503-l60cdllh 271 4 al al NNP cord-298503-l60cdllh 271 5 . . NNP cord-298503-l60cdllh 271 6 , , , cord-298503-l60cdllh 271 7 2002 2002 CD cord-298503-l60cdllh 272 1 ; ; : cord-298503-l60cdllh 272 2 Marie Marie NNP cord-298503-l60cdllh 272 3 et et NNP cord-298503-l60cdllh 272 4 al al NNP cord-298503-l60cdllh 272 5 . . NNP cord-298503-l60cdllh 272 6 , , , cord-298503-l60cdllh 272 7 2009 2009 CD cord-298503-l60cdllh 272 8 ; ; : cord-298503-l60cdllh 272 9 Gee Gee NNP cord-298503-l60cdllh 272 10 et et NNP cord-298503-l60cdllh 272 11 al al NNP cord-298503-l60cdllh 272 12 . . NNP cord-298503-l60cdllh 272 13 , , , cord-298503-l60cdllh 272 14 2011 2011 CD cord-298503-l60cdllh 272 15 ) ) -RRB- cord-298503-l60cdllh 272 16 . . . cord-298503-l60cdllh 273 1 Further further RB cord-298503-l60cdllh 273 2 , , , cord-298503-l60cdllh 273 3 the the DT cord-298503-l60cdllh 273 4 presence presence NN cord-298503-l60cdllh 273 5 of of IN cord-298503-l60cdllh 273 6 the the DT cord-298503-l60cdllh 273 7 IC IC NNP cord-298503-l60cdllh 273 8 in in IN cord-298503-l60cdllh 273 9 neuronal neuronal JJ cord-298503-l60cdllh 273 10 dendrites dendrite NNS cord-298503-l60cdllh 273 11 may may MD cord-298503-l60cdllh 273 12 provide provide VB cord-298503-l60cdllh 273 13 a a DT cord-298503-l60cdllh 273 14 Golgi Golgi NNP cord-298503-l60cdllh 273 15 - - HYPH cord-298503-l60cdllh 273 16 independent independent JJ cord-298503-l60cdllh 273 17 satellite satellite NN cord-298503-l60cdllh 273 18 pathway pathway NN cord-298503-l60cdllh 273 19 for for IN cord-298503-l60cdllh 273 20 local local JJ cord-298503-l60cdllh 273 21 dendritic dendritic JJ cord-298503-l60cdllh 273 22 trafficking trafficking NN cord-298503-l60cdllh 274 1 ( ( -LRB- cord-298503-l60cdllh 274 2 Krijnse Krijnse NNP cord-298503-l60cdllh 274 3 - - HYPH cord-298503-l60cdllh 274 4 Locker Locker NNP cord-298503-l60cdllh 274 5 et et FW cord-298503-l60cdllh 274 6 al al NNP cord-298503-l60cdllh 274 7 . . NNP cord-298503-l60cdllh 274 8 , , , cord-298503-l60cdllh 274 9 1995 1995 CD cord-298503-l60cdllh 275 1 ; ; : cord-298503-l60cdllh 275 2 Sannerud Sannerud NNP cord-298503-l60cdllh 275 3 et et NNP cord-298503-l60cdllh 275 4 al al NNP cord-298503-l60cdllh 275 5 . . NNP cord-298503-l60cdllh 275 6 , , , cord-298503-l60cdllh 275 7 2006 2006 CD cord-298503-l60cdllh 275 8 ; ; : cord-298503-l60cdllh 275 9 Ehlers Ehlers NNP cord-298503-l60cdllh 275 10 , , , cord-298503-l60cdllh 275 11 2013 2013 CD cord-298503-l60cdllh 275 12 ) ) -RRB- cord-298503-l60cdllh 275 13 . . . cord-298503-l60cdllh 276 1 Questioning question VBG cord-298503-l60cdllh 276 2 the the DT cord-298503-l60cdllh 276 3 studies study NNS cord-298503-l60cdllh 276 4 on on IN cord-298503-l60cdllh 276 5 coronavirus coronavirus NN cord-298503-l60cdllh 276 6 maturation maturation NN cord-298503-l60cdllh 276 7 , , , cord-298503-l60cdllh 276 8 which which WDT cord-298503-l60cdllh 276 9 suggested suggest VBD cord-298503-l60cdllh 276 10 that that IN cord-298503-l60cdllh 276 11 O o NN cord-298503-l60cdllh 276 12 - - HYPH cord-298503-l60cdllh 276 13 glycosylation glycosylation NN cord-298503-l60cdllh 276 14 is be VBZ cord-298503-l60cdllh 276 15 initiated initiate VBN cord-298503-l60cdllh 276 16 in in IN cord-298503-l60cdllh 276 17 the the DT cord-298503-l60cdllh 276 18 IC IC NNP cord-298503-l60cdllh 276 19 ( ( -LRB- cord-298503-l60cdllh 276 20 see see VB cord-298503-l60cdllh 276 21 above above RB cord-298503-l60cdllh 276 22 ) ) -RRB- cord-298503-l60cdllh 276 23 , , , cord-298503-l60cdllh 276 24 subsequent subsequent JJ cord-298503-l60cdllh 276 25 EM EM NNP cord-298503-l60cdllh 276 26 studies study NNS cord-298503-l60cdllh 276 27 showed show VBD cord-298503-l60cdllh 276 28 that that IN cord-298503-l60cdllh 276 29 the the DT cord-298503-l60cdllh 276 30 GalNActransferases galnactransferase NNS cord-298503-l60cdllh 276 31 are be VBP cord-298503-l60cdllh 276 32 predominantly predominantly RB cord-298503-l60cdllh 276 33 found find VBN cord-298503-l60cdllh 276 34 in in IN cord-298503-l60cdllh 276 35 the the DT cord-298503-l60cdllh 276 36 Golgi Golgi NNP cord-298503-l60cdllh 276 37 . . . cord-298503-l60cdllh 277 1 However however RB cord-298503-l60cdllh 277 2 , , , cord-298503-l60cdllh 277 3 the the DT cord-298503-l60cdllh 277 4 activation activation NN cord-298503-l60cdllh 277 5 of of IN cord-298503-l60cdllh 277 6 cells cell NNS cord-298503-l60cdllh 277 7 ( ( -LRB- cord-298503-l60cdllh 277 8 by by IN cord-298503-l60cdllh 277 9 epidermal epidermal JJ cord-298503-l60cdllh 277 10 growth growth NN cord-298503-l60cdllh 277 11 factor factor NN cord-298503-l60cdllh 277 12 ) ) -RRB- cord-298503-l60cdllh 277 13 causes cause VBZ cord-298503-l60cdllh 277 14 their -PRON- PRP$ cord-298503-l60cdllh 277 15 incorporation incorporation NN cord-298503-l60cdllh 277 16 into into IN cord-298503-l60cdllh 277 17 COPI COPI NNP cord-298503-l60cdllh 277 18 vesicles vesicle NNS cord-298503-l60cdllh 277 19 and and CC cord-298503-l60cdllh 277 20 relocation relocation NN cord-298503-l60cdllh 277 21 to to IN cord-298503-l60cdllh 277 22 the the DT cord-298503-l60cdllh 277 23 IC IC NNP cord-298503-l60cdllh 277 24 and and CC cord-298503-l60cdllh 277 25 ER ER NNP cord-298503-l60cdllh 277 26 , , , cord-298503-l60cdllh 277 27 which which WDT cord-298503-l60cdllh 277 28 consequently consequently RB cord-298503-l60cdllh 277 29 become become VBP cord-298503-l60cdllh 277 30 positive positive JJ cord-298503-l60cdllh 277 31 for for IN cord-298503-l60cdllh 277 32 the the DT cord-298503-l60cdllh 277 33 lectin lectin NN cord-298503-l60cdllh 277 34 Helix Helix NNP cord-298503-l60cdllh 277 35 pomatia pomatia NN cord-298503-l60cdllh 277 36 ( ( -LRB- cord-298503-l60cdllh 277 37 Gill Gill NNP cord-298503-l60cdllh 277 38 et et NNP cord-298503-l60cdllh 277 39 al al NNP cord-298503-l60cdllh 277 40 . . NNP cord-298503-l60cdllh 277 41 , , , cord-298503-l60cdllh 277 42 2010 2010 CD cord-298503-l60cdllh 277 43 ) ) -RRB- cord-298503-l60cdllh 277 44 . . . cord-298503-l60cdllh 278 1 The the DT cord-298503-l60cdllh 278 2 cycling cycling NN cord-298503-l60cdllh 278 3 of of IN cord-298503-l60cdllh 278 4 cis cis NNP cord-298503-l60cdllh 278 5 - - HYPH cord-298503-l60cdllh 278 6 Golgi Golgi NNP cord-298503-l60cdllh 278 7 proteins protein NNS cord-298503-l60cdllh 278 8 to to IN cord-298503-l60cdllh 278 9 the the DT cord-298503-l60cdllh 278 10 IC IC NNP cord-298503-l60cdllh 278 11 could could MD cord-298503-l60cdllh 278 12 be be VB cord-298503-l60cdllh 278 13 a a DT cord-298503-l60cdllh 278 14 constitutive constitutive JJ cord-298503-l60cdllh 278 15 event event NN cord-298503-l60cdllh 278 16 ( ( -LRB- cord-298503-l60cdllh 278 17 Lin Lin NNP cord-298503-l60cdllh 278 18 et et NNP cord-298503-l60cdllh 278 19 al al NNP cord-298503-l60cdllh 278 20 . . NNP cord-298503-l60cdllh 278 21 , , , cord-298503-l60cdllh 278 22 1999 1999 CD cord-298503-l60cdllh 278 23 ; ; : cord-298503-l60cdllh 278 24 Marra Marra NNP cord-298503-l60cdllh 278 25 et et NNP cord-298503-l60cdllh 278 26 al al NNP cord-298503-l60cdllh 278 27 . . NNP cord-298503-l60cdllh 278 28 , , , cord-298503-l60cdllh 278 29 2001 2001 CD cord-298503-l60cdllh 278 30 ; ; : cord-298503-l60cdllh 279 1 Jarvela Jarvela NNP cord-298503-l60cdllh 279 2 and and CC cord-298503-l60cdllh 279 3 Linstedt Linstedt NNP cord-298503-l60cdllh 279 4 , , , cord-298503-l60cdllh 279 5 2012 2012 CD cord-298503-l60cdllh 279 6 ) ) -RRB- cord-298503-l60cdllh 279 7 . . . cord-298503-l60cdllh 280 1 Moreover moreover RB cord-298503-l60cdllh 280 2 , , , cord-298503-l60cdllh 280 3 the the DT cord-298503-l60cdllh 280 4 construction construction NN cord-298503-l60cdllh 280 5 of of IN cord-298503-l60cdllh 280 6 the the DT cord-298503-l60cdllh 280 7 sugar sugar NN cord-298503-l60cdllh 280 8 chains chain NNS cord-298503-l60cdllh 280 9 on on IN cord-298503-l60cdllh 280 10 proteoglycans proteoglycan NNS cord-298503-l60cdllh 280 11 has have VBZ cord-298503-l60cdllh 280 12 been be VBN cord-298503-l60cdllh 280 13 suggested suggest VBN cord-298503-l60cdllh 280 14 to to TO cord-298503-l60cdllh 280 15 begin begin VB cord-298503-l60cdllh 280 16 in in IN cord-298503-l60cdllh 280 17 the the DT cord-298503-l60cdllh 280 18 IC IC NNP cord-298503-l60cdllh 280 19 ( ( -LRB- cord-298503-l60cdllh 280 20 Jönsson Jönsson NNP cord-298503-l60cdllh 280 21 et et NNP cord-298503-l60cdllh 280 22 al al NNP cord-298503-l60cdllh 280 23 . . NNP cord-298503-l60cdllh 280 24 , , , cord-298503-l60cdllh 280 25 2003 2003 CD cord-298503-l60cdllh 280 26 ) ) -RRB- cord-298503-l60cdllh 280 27 . . . cord-298503-l60cdllh 281 1 The the DT cord-298503-l60cdllh 281 2 KDEL KDEL NNP cord-298503-l60cdllh 281 3 - - HYPH cord-298503-l60cdllh 281 4 containing contain VBG cord-298503-l60cdllh 281 5 molecular molecular JJ cord-298503-l60cdllh 281 6 chaperones chaperone NNS cord-298503-l60cdllh 281 7 present present JJ cord-298503-l60cdllh 281 8 in in IN cord-298503-l60cdllh 281 9 the the DT cord-298503-l60cdllh 281 10 IC IC NNP cord-298503-l60cdllh 281 11 ( ( -LRB- cord-298503-l60cdllh 281 12 BiP BiP NNP cord-298503-l60cdllh 281 13 , , , cord-298503-l60cdllh 281 14 PDI PDI NNP cord-298503-l60cdllh 281 15 , , , cord-298503-l60cdllh 281 16 and and CC cord-298503-l60cdllh 281 17 GRP94 GRP94 NNP cord-298503-l60cdllh 281 18 ; ; : cord-298503-l60cdllh 281 19 see see VB cord-298503-l60cdllh 281 20 above above RB cord-298503-l60cdllh 281 21 ) ) -RRB- cord-298503-l60cdllh 281 22 could could MD cord-298503-l60cdllh 281 23 be be VB cord-298503-l60cdllh 281 24 cycling cycle VBG cord-298503-l60cdllh 281 25 while while IN cord-298503-l60cdllh 281 26 still still RB cord-298503-l60cdllh 281 27 bound bind VBN cord-298503-l60cdllh 281 28 to to IN cord-298503-l60cdllh 281 29 their -PRON- PRP$ cord-298503-l60cdllh 281 30 unfolded unfold VBN cord-298503-l60cdllh 281 31 client client NN cord-298503-l60cdllh 281 32 proteins protein NNS cord-298503-l60cdllh 281 33 , , , cord-298503-l60cdllh 281 34 opening open VBG cord-298503-l60cdllh 281 35 for for IN cord-298503-l60cdllh 281 36 a a DT cord-298503-l60cdllh 281 37 post post JJ cord-298503-l60cdllh 281 38 - - JJ cord-298503-l60cdllh 281 39 ER er JJ cord-298503-l60cdllh 281 40 level level NN cord-298503-l60cdllh 281 41 of of IN cord-298503-l60cdllh 281 42 protein protein NN cord-298503-l60cdllh 281 43 folding folding NN cord-298503-l60cdllh 281 44 and and CC cord-298503-l60cdllh 281 45 quality quality NN cord-298503-l60cdllh 281 46 control control NN cord-298503-l60cdllh 281 47 . . . cord-298503-l60cdllh 282 1 The the DT cord-298503-l60cdllh 282 2 presence presence NN cord-298503-l60cdllh 282 3 of of IN cord-298503-l60cdllh 282 4 quality quality NN cord-298503-l60cdllh 282 5 control control NN cord-298503-l60cdllh 282 6 machinery machinery NN cord-298503-l60cdllh 282 7 in in IN cord-298503-l60cdllh 282 8 the the DT cord-298503-l60cdllh 282 9 IC IC NNP cord-298503-l60cdllh 282 10 and and CC cord-298503-l60cdllh 282 11 the the DT cord-298503-l60cdllh 282 12 finding finding NN cord-298503-l60cdllh 282 13 that that IN cord-298503-l60cdllh 282 14 the the DT cord-298503-l60cdllh 282 15 ER ER NNP cord-298503-l60cdllh 282 16 - - HYPH cord-298503-l60cdllh 282 17 associated associate VBN cord-298503-l60cdllh 282 18 degradation degradation NN cord-298503-l60cdllh 282 19 of of IN cord-298503-l60cdllh 282 20 certain certain JJ cord-298503-l60cdllh 282 21 proteins protein NNS cord-298503-l60cdllh 282 22 requires require VBZ cord-298503-l60cdllh 282 23 their -PRON- PRP$ cord-298503-l60cdllh 282 24 ER ER NNP cord-298503-l60cdllh 282 25 export export NN cord-298503-l60cdllh 282 26 is be VBZ cord-298503-l60cdllh 282 27 in in IN cord-298503-l60cdllh 282 28 accordance accordance NN cord-298503-l60cdllh 282 29 with with IN cord-298503-l60cdllh 282 30 this this DT cord-298503-l60cdllh 282 31 idea idea NN cord-298503-l60cdllh 282 32 ( ( -LRB- cord-298503-l60cdllh 282 33 Zuber Zuber NNP cord-298503-l60cdllh 282 34 et et FW cord-298503-l60cdllh 282 35 al al NNP cord-298503-l60cdllh 282 36 . . NNP cord-298503-l60cdllh 282 37 , , , cord-298503-l60cdllh 282 38 2001 2001 CD cord-298503-l60cdllh 282 39 ; ; : cord-298503-l60cdllh 283 1 Anelli Anelli NNP cord-298503-l60cdllh 283 2 and and CC cord-298503-l60cdllh 283 3 Sitia Sitia NNP cord-298503-l60cdllh 283 4 , , , cord-298503-l60cdllh 283 5 2008 2008 CD cord-298503-l60cdllh 283 6 ) ) -RRB- cord-298503-l60cdllh 283 7 . . . cord-298503-l60cdllh 284 1 The the DT cord-298503-l60cdllh 284 2 PDI PDI NNP cord-298503-l60cdllh 284 3 family family NN cord-298503-l60cdllh 284 4 member member NN cord-298503-l60cdllh 284 5 ERp44 ERp44 NNP cord-298503-l60cdllh 284 6 and and CC cord-298503-l60cdllh 284 7 p58/ p58/ NNP cord-298503-l60cdllh 284 8 ERGIC-53 ergic-53 CD cord-298503-l60cdllh 284 9 cooperate cooperate NNS cord-298503-l60cdllh 284 10 in in IN cord-298503-l60cdllh 284 11 the the DT cord-298503-l60cdllh 284 12 IC IC NNP cord-298503-l60cdllh 284 13 / / SYM cord-298503-l60cdllh 284 14 cis cis NNP cord-298503-l60cdllh 284 15 - - HYPH cord-298503-l60cdllh 284 16 Golgi Golgi NNP cord-298503-l60cdllh 284 17 in in IN cord-298503-l60cdllh 284 18 sequential sequential JJ cord-298503-l60cdllh 284 19 assembly assembly NN cord-298503-l60cdllh 284 20 of of IN cord-298503-l60cdllh 284 21 IgM IgM NNP cord-298503-l60cdllh 284 22 polymers polymers NNP cord-298503-l60cdllh 284 23 ( ( -LRB- cord-298503-l60cdllh 284 24 Anelli Anelli NNP cord-298503-l60cdllh 284 25 and and CC cord-298503-l60cdllh 284 26 Sitia Sitia NNP cord-298503-l60cdllh 284 27 , , , cord-298503-l60cdllh 284 28 2008 2008 CD cord-298503-l60cdllh 284 29 ) ) -RRB- cord-298503-l60cdllh 284 30 . . . cord-298503-l60cdllh 285 1 Unassembled unassembled JJ cord-298503-l60cdllh 285 2 IgM IgM NNP cord-298503-l60cdllh 285 3 or or CC cord-298503-l60cdllh 285 4 T T NNP cord-298503-l60cdllh 285 5 - - HYPH cord-298503-l60cdllh 285 6 cell cell NN cord-298503-l60cdllh 285 7 antigen antigen NN cord-298503-l60cdllh 285 8 receptor receptor NN cord-298503-l60cdllh 285 9 subunits subunit NNS cord-298503-l60cdllh 285 10 bound bind VBN cord-298503-l60cdllh 285 11 to to IN cord-298503-l60cdllh 285 12 ERp44 ERp44 NNP cord-298503-l60cdllh 285 13 or or CC cord-298503-l60cdllh 285 14 BiP bip NN cord-298503-l60cdllh 285 15 , , , cord-298503-l60cdllh 285 16 respectively respectively RB cord-298503-l60cdllh 285 17 , , , cord-298503-l60cdllh 285 18 can can MD cord-298503-l60cdllh 285 19 be be VB cord-298503-l60cdllh 285 20 retrieved retrieve VBN cord-298503-l60cdllh 285 21 to to IN cord-298503-l60cdllh 285 22 the the DT cord-298503-l60cdllh 285 23 ER ER NNP cord-298503-l60cdllh 285 24 by by IN cord-298503-l60cdllh 285 25 the the DT cord-298503-l60cdllh 285 26 KDEL KDEL NNP cord-298503-l60cdllh 285 27 - - HYPH cord-298503-l60cdllh 285 28 receptor receptor NN cord-298503-l60cdllh 285 29 in in IN cord-298503-l60cdllh 285 30 a a DT cord-298503-l60cdllh 285 31 pH ph JJ cord-298503-l60cdllh 285 32 - - HYPH cord-298503-l60cdllh 285 33 dependent dependent JJ cord-298503-l60cdllh 285 34 manner manner NN cord-298503-l60cdllh 285 35 ( ( -LRB- cord-298503-l60cdllh 286 1 Yamamoto Yamamoto NNP cord-298503-l60cdllh 286 2 et et NNP cord-298503-l60cdllh 286 3 al al NNP cord-298503-l60cdllh 286 4 . . NNP cord-298503-l60cdllh 286 5 , , , cord-298503-l60cdllh 286 6 2001 2001 CD cord-298503-l60cdllh 287 1 ; ; : cord-298503-l60cdllh 287 2 Vavassori Vavassori NNP cord-298503-l60cdllh 287 3 et et FW cord-298503-l60cdllh 287 4 al al NNP cord-298503-l60cdllh 287 5 . . NNP cord-298503-l60cdllh 287 6 , , , cord-298503-l60cdllh 287 7 2013 2013 CD cord-298503-l60cdllh 287 8 ) ) -RRB- cord-298503-l60cdllh 287 9 , , , cord-298503-l60cdllh 287 10 similarly similarly RB cord-298503-l60cdllh 287 11 as as IN cord-298503-l60cdllh 287 12 the the DT cord-298503-l60cdllh 287 13 overexpressed overexpresse VBN cord-298503-l60cdllh 287 14 , , , cord-298503-l60cdllh 287 15 misfolded misfolde VBN cord-298503-l60cdllh 287 16 VSV VSV NNP cord-298503-l60cdllh 287 17 G G NNP cord-298503-l60cdllh 287 18 - - HYPH cord-298503-l60cdllh 287 19 protein protein NN cord-298503-l60cdllh 287 20 ( ( -LRB- cord-298503-l60cdllh 287 21 Hammond Hammond NNP cord-298503-l60cdllh 287 22 and and CC cord-298503-l60cdllh 287 23 Helenius Helenius NNP cord-298503-l60cdllh 287 24 , , , cord-298503-l60cdllh 287 25 1994 1994 CD cord-298503-l60cdllh 287 26 ) ) -RRB- cord-298503-l60cdllh 287 27 and and CC cord-298503-l60cdllh 287 28 mutant mutant JJ cord-298503-l60cdllh 287 29 V2 V2 NNP cord-298503-l60cdllh 287 30 vasopressin vasopressin NN cord-298503-l60cdllh 287 31 receptors receptor NNS cord-298503-l60cdllh 287 32 ( ( -LRB- cord-298503-l60cdllh 287 33 Hermosilla Hermosilla NNP cord-298503-l60cdllh 287 34 et et NNP cord-298503-l60cdllh 287 35 al al NNP cord-298503-l60cdllh 287 36 . . NNP cord-298503-l60cdllh 287 37 , , , cord-298503-l60cdllh 287 38 2004 2004 CD cord-298503-l60cdllh 287 39 ) ) -RRB- cord-298503-l60cdllh 287 40 . . . cord-298503-l60cdllh 288 1 Additional additional JJ cord-298503-l60cdllh 288 2 proof proof NN cord-298503-l60cdllh 288 3 for for IN cord-298503-l60cdllh 288 4 a a DT cord-298503-l60cdllh 288 5 post post JJ cord-298503-l60cdllh 288 6 - - JJ cord-298503-l60cdllh 288 7 ER er JJ cord-298503-l60cdllh 288 8 checkpoint checkpoint NN cord-298503-l60cdllh 288 9 is be VBZ cord-298503-l60cdllh 288 10 provided provide VBN cord-298503-l60cdllh 288 11 by by IN cord-298503-l60cdllh 288 12 studies study NNS cord-298503-l60cdllh 288 13 showing show VBG cord-298503-l60cdllh 288 14 the the DT cord-298503-l60cdllh 288 15 accumulation accumulation NN cord-298503-l60cdllh 288 16 of of IN cord-298503-l60cdllh 288 17 the the DT cord-298503-l60cdllh 288 18 deletion deletion NN cord-298503-l60cdllh 288 19 mutant mutant NN cord-298503-l60cdllh 288 20 DF508 DF508 NNP cord-298503-l60cdllh 288 21 of of IN cord-298503-l60cdllh 288 22 CFTR CFTR NNP cord-298503-l60cdllh 289 1 ( ( -LRB- cord-298503-l60cdllh 289 2 Gilbert Gilbert NNP cord-298503-l60cdllh 289 3 et et NNP cord-298503-l60cdllh 289 4 al al NNP cord-298503-l60cdllh 289 5 . . NNP cord-298503-l60cdllh 289 6 , , , cord-298503-l60cdllh 289 7 1998 1998 CD cord-298503-l60cdllh 289 8 ) ) -RRB- cord-298503-l60cdllh 289 9 , , , cord-298503-l60cdllh 289 10 misfolded misfolde VBN cord-298503-l60cdllh 289 11 MHC MHC NNP cord-298503-l60cdllh 289 12 class class NN cord-298503-l60cdllh 290 1 I -PRON- PRP cord-298503-l60cdllh 290 2 proteins protein VBZ cord-298503-l60cdllh 291 1 ( ( -LRB- cord-298503-l60cdllh 291 2 Hsu Hsu NNP cord-298503-l60cdllh 291 3 et et NNP cord-298503-l60cdllh 291 4 al al NNP cord-298503-l60cdllh 291 5 . . NNP cord-298503-l60cdllh 291 6 , , , cord-298503-l60cdllh 291 7 1991 1991 CD cord-298503-l60cdllh 291 8 ; ; : cord-298503-l60cdllh 291 9 Raposo Raposo NNP cord-298503-l60cdllh 291 10 et et NNP cord-298503-l60cdllh 291 11 al al NNP cord-298503-l60cdllh 291 12 . . NNP cord-298503-l60cdllh 291 13 , , , cord-298503-l60cdllh 291 14 1995 1995 CD cord-298503-l60cdllh 291 15 ) ) -RRB- cord-298503-l60cdllh 291 16 , , , cord-298503-l60cdllh 291 17 and and CC cord-298503-l60cdllh 291 18 proinsulin proinsulin NNP cord-298503-l60cdllh 291 19 ( ( -LRB- cord-298503-l60cdllh 291 20 Zuber Zuber NNP cord-298503-l60cdllh 291 21 et et NNP cord-298503-l60cdllh 291 22 al al NNP cord-298503-l60cdllh 291 23 . . NNP cord-298503-l60cdllh 291 24 , , , cord-298503-l60cdllh 291 25 2004 2004 CD cord-298503-l60cdllh 291 26 ) ) -RRB- cord-298503-l60cdllh 291 27 in in IN cord-298503-l60cdllh 291 28 expanded expand VBN cord-298503-l60cdllh 291 29 IC IC NNP cord-298503-l60cdllh 291 30 elements element NNS cord-298503-l60cdllh 291 31 . . . cord-298503-l60cdllh 292 1 The the DT cord-298503-l60cdllh 292 2 level level NN cord-298503-l60cdllh 292 3 of of IN cord-298503-l60cdllh 293 1 p58 p58 NNP cord-298503-l60cdllh 293 2 / / SYM cord-298503-l60cdllh 293 3 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 293 4 mRNA mrna NN cord-298503-l60cdllh 293 5 is be VBZ cord-298503-l60cdllh 293 6 up up RB cord-298503-l60cdllh 293 7 - - HYPH cord-298503-l60cdllh 293 8 regulated regulate VBN cord-298503-l60cdllh 293 9 by by IN cord-298503-l60cdllh 293 10 the the DT cord-298503-l60cdllh 293 11 unfolded unfold VBN cord-298503-l60cdllh 293 12 protein protein NN cord-298503-l60cdllh 293 13 response response NN cord-298503-l60cdllh 293 14 ( ( -LRB- cord-298503-l60cdllh 293 15 UPR UPR NNP cord-298503-l60cdllh 293 16 ) ) -RRB- cord-298503-l60cdllh 293 17 , , , cord-298503-l60cdllh 293 18 which which WDT cord-298503-l60cdllh 293 19 also also RB cord-298503-l60cdllh 293 20 requires require VBZ cord-298503-l60cdllh 293 21 yeast yeast NN cord-298503-l60cdllh 293 22 Ypt1 Ypt1 NNP cord-298503-l60cdllh 293 23 function function NN cord-298503-l60cdllh 293 24 , , , cord-298503-l60cdllh 293 25 supporting support VBG cord-298503-l60cdllh 293 26 a a DT cord-298503-l60cdllh 293 27 link link NN cord-298503-l60cdllh 293 28 between between IN cord-298503-l60cdllh 293 29 this this DT cord-298503-l60cdllh 293 30 signaling signal VBG cord-298503-l60cdllh 293 31 pathway pathway NN cord-298503-l60cdllh 293 32 and and CC cord-298503-l60cdllh 293 33 ER ER NNP cord-298503-l60cdllh 293 34 - - HYPH cord-298503-l60cdllh 293 35 Golgi Golgi NNP cord-298503-l60cdllh 293 36 trafficking trafficking NN cord-298503-l60cdllh 294 1 ( ( -LRB- cord-298503-l60cdllh 294 2 Nyfeler Nyfeler NNP cord-298503-l60cdllh 294 3 et et NNP cord-298503-l60cdllh 294 4 al al NNP cord-298503-l60cdllh 294 5 . . . cord-298503-l60cdllh 295 1 , , , cord-298503-l60cdllh 295 2 2003 2003 CD cord-298503-l60cdllh 295 3 ; ; : cord-298503-l60cdllh 295 4 Tsvetanova Tsvetanova NNP cord-298503-l60cdllh 295 5 et et NNP cord-298503-l60cdllh 295 6 al al NNP cord-298503-l60cdllh 295 7 . . NNP cord-298503-l60cdllh 295 8 , , , cord-298503-l60cdllh 295 9 2012 2012 CD cord-298503-l60cdllh 295 10 ) ) -RRB- cord-298503-l60cdllh 295 11 . . . cord-298503-l60cdllh 296 1 Protein protein NN cord-298503-l60cdllh 296 2 kinases kinase NNS cord-298503-l60cdllh 296 3 Src Src NNP cord-298503-l60cdllh 296 4 , , , cord-298503-l60cdllh 296 5 aPKC apkc NN cord-298503-l60cdllh 296 6 , , , cord-298503-l60cdllh 297 1 and and CC cord-298503-l60cdllh 297 2 Scyl1 Scyl1 NNS cord-298503-l60cdllh 297 3 have have VBP cord-298503-l60cdllh 297 4 been be VBN cord-298503-l60cdllh 297 5 implicated implicate VBN cord-298503-l60cdllh 297 6 in in IN cord-298503-l60cdllh 297 7 COPI COPI NNP cord-298503-l60cdllh 297 8 function function NN cord-298503-l60cdllh 297 9 at at IN cord-298503-l60cdllh 297 10 the the DT cord-298503-l60cdllh 297 11 level level NN cord-298503-l60cdllh 297 12 of of IN cord-298503-l60cdllh 297 13 the the DT cord-298503-l60cdllh 297 14 IC IC NNP cord-298503-l60cdllh 297 15 ( ( -LRB- cord-298503-l60cdllh 297 16 Tisdale Tisdale NNP cord-298503-l60cdllh 297 17 and and CC cord-298503-l60cdllh 297 18 Artalejo Artalejo NNP cord-298503-l60cdllh 297 19 , , , cord-298503-l60cdllh 297 20 2006 2006 CD cord-298503-l60cdllh 297 21 ; ; . cord-298503-l60cdllh 298 1 Hamlin Hamlin NNP cord-298503-l60cdllh 298 2 et et NNP cord-298503-l60cdllh 298 3 al al NNP cord-298503-l60cdllh 298 4 . . NNP cord-298503-l60cdllh 298 5 , , , cord-298503-l60cdllh 298 6 2014 2014 CD cord-298503-l60cdllh 298 7 ) ) -RRB- cord-298503-l60cdllh 298 8 and and CC cord-298503-l60cdllh 298 9 PKC PKC NNP cord-298503-l60cdllh 298 10 and and CC cord-298503-l60cdllh 298 11 its -PRON- PRP$ cord-298503-l60cdllh 298 12 downstream downstream JJ cord-298503-l60cdllh 298 13 effectors effector NNS cord-298503-l60cdllh 298 14 appear appear VBP cord-298503-l60cdllh 298 15 to to TO cord-298503-l60cdllh 298 16 control control VB cord-298503-l60cdllh 298 17 IC IC NNP cord-298503-l60cdllh 298 18 morphology morphology NN cord-298503-l60cdllh 299 1 ( ( -LRB- cord-298503-l60cdllh 299 2 Ben Ben NNP cord-298503-l60cdllh 299 3 - - HYPH cord-298503-l60cdllh 299 4 Tekaya Tekaya NNP cord-298503-l60cdllh 299 5 et et NNP cord-298503-l60cdllh 299 6 al al NNP cord-298503-l60cdllh 299 7 . . . cord-298503-l60cdllh 300 1 , , , cord-298503-l60cdllh 300 2 2010 2010 CD cord-298503-l60cdllh 300 3 ; ; : cord-298503-l60cdllh 300 4 Sugawara Sugawara NNP cord-298503-l60cdllh 300 5 et et NNP cord-298503-l60cdllh 300 6 al al NNP cord-298503-l60cdllh 300 7 . . NNP cord-298503-l60cdllh 300 8 , , , cord-298503-l60cdllh 300 9 2012 2012 CD cord-298503-l60cdllh 300 10 ) ) -RRB- cord-298503-l60cdllh 300 11 . . . cord-298503-l60cdllh 301 1 The the DT cord-298503-l60cdllh 301 2 activation activation NN cord-298503-l60cdllh 301 3 of of IN cord-298503-l60cdllh 301 4 neuronal neuronal JJ cord-298503-l60cdllh 301 5 Trk Trk NNP cord-298503-l60cdllh 301 6 receptor receptor NN cord-298503-l60cdllh 301 7 tyrosine tyrosine NN cord-298503-l60cdllh 301 8 kinases kinase NNS cord-298503-l60cdllh 301 9 in in IN cord-298503-l60cdllh 301 10 the the DT cord-298503-l60cdllh 301 11 IC IC NNP cord-298503-l60cdllh 301 12 initiates initiate VBZ cord-298503-l60cdllh 301 13 signaling signal VBG cord-298503-l60cdllh 301 14 via via IN cord-298503-l60cdllh 301 15 the the DT cord-298503-l60cdllh 301 16 MEK MEK NNP cord-298503-l60cdllh 301 17 pathway pathway NN cord-298503-l60cdllh 301 18 leading lead VBG cord-298503-l60cdllh 301 19 to to IN cord-298503-l60cdllh 301 20 Golgi Golgi NNP cord-298503-l60cdllh 301 21 fragmentation fragmentation NN cord-298503-l60cdllh 302 1 ( ( -LRB- cord-298503-l60cdllh 302 2 Schecterson Schecterson NNP cord-298503-l60cdllh 302 3 et et NNP cord-298503-l60cdllh 302 4 al al NNP cord-298503-l60cdllh 302 5 . . NNP cord-298503-l60cdllh 302 6 , , , cord-298503-l60cdllh 302 7 2010 2010 CD cord-298503-l60cdllh 302 8 ) ) -RRB- cord-298503-l60cdllh 302 9 . . . cord-298503-l60cdllh 303 1 Membranes membrane NNS cord-298503-l60cdllh 303 2 enriched enrich VBN cord-298503-l60cdllh 303 3 in in IN cord-298503-l60cdllh 303 4 IC IC NNP cord-298503-l60cdllh 303 5 markers marker NNS cord-298503-l60cdllh 303 6 ( ( -LRB- cord-298503-l60cdllh 303 7 p58 p58 NNP cord-298503-l60cdllh 303 8 / / SYM cord-298503-l60cdllh 303 9 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 303 10 / / SYM cord-298503-l60cdllh 303 11 LMAN1 LMAN1 NNP cord-298503-l60cdllh 303 12 , , , cord-298503-l60cdllh 303 13 KDEL KDEL NNP cord-298503-l60cdllh 303 14 - - HYPH cord-298503-l60cdllh 303 15 receptor receptor NN cord-298503-l60cdllh 303 16 , , , cord-298503-l60cdllh 303 17 and and CC cord-298503-l60cdllh 303 18 Sec22B Sec22B NNP cord-298503-l60cdllh 303 19 ) ) -RRB- cord-298503-l60cdllh 303 20 play play VB cord-298503-l60cdllh 303 21 a a DT cord-298503-l60cdllh 303 22 role role NN cord-298503-l60cdllh 303 23 in in IN cord-298503-l60cdllh 303 24 the the DT cord-298503-l60cdllh 303 25 biogenesis biogenesis NN cord-298503-l60cdllh 303 26 of of IN cord-298503-l60cdllh 303 27 autophagosomes autophagosomes NNP cord-298503-l60cdllh 303 28 by by IN cord-298503-l60cdllh 303 29 representing represent VBG cord-298503-l60cdllh 303 30 the the DT cord-298503-l60cdllh 303 31 primary primary JJ cord-298503-l60cdllh 303 32 membrane membrane NN cord-298503-l60cdllh 303 33 source source NN cord-298503-l60cdllh 303 34 for for IN cord-298503-l60cdllh 303 35 the the DT cord-298503-l60cdllh 303 36 lipidation lipidation NN cord-298503-l60cdllh 303 37 of of IN cord-298503-l60cdllh 303 38 LC3 LC3 NNP cord-298503-l60cdllh 303 39 , , , cord-298503-l60cdllh 303 40 which which WDT cord-298503-l60cdllh 303 41 triggers trigger VBZ cord-298503-l60cdllh 303 42 this this DT cord-298503-l60cdllh 303 43 process process NN cord-298503-l60cdllh 304 1 ( ( -LRB- cord-298503-l60cdllh 304 2 Ge Ge NNP cord-298503-l60cdllh 304 3 et et NNP cord-298503-l60cdllh 304 4 al al NNP cord-298503-l60cdllh 304 5 . . NNP cord-298503-l60cdllh 304 6 , , , cord-298503-l60cdllh 304 7 2013 2013 CD cord-298503-l60cdllh 304 8 ) ) -RRB- cord-298503-l60cdllh 304 9 . . . cord-298503-l60cdllh 305 1 Moreover moreover RB cord-298503-l60cdllh 305 2 , , , cord-298503-l60cdllh 305 3 Ypt1 Ypt1 NNP cord-298503-l60cdllh 305 4 / / SYM cord-298503-l60cdllh 305 5 Rab1 Rab1 NNP cord-298503-l60cdllh 305 6 is be VBZ cord-298503-l60cdllh 305 7 a a DT cord-298503-l60cdllh 305 8 key key JJ cord-298503-l60cdllh 305 9 regulator regulator NN cord-298503-l60cdllh 305 10 of of IN cord-298503-l60cdllh 305 11 autophagy autophagy NN cord-298503-l60cdllh 305 12 in in IN cord-298503-l60cdllh 305 13 yeast yeast NN cord-298503-l60cdllh 305 14 and and CC cord-298503-l60cdllh 305 15 mammals mammal NNS cord-298503-l60cdllh 305 16 ( ( -LRB- cord-298503-l60cdllh 305 17 Lynch- Lynch- NNP cord-298503-l60cdllh 305 18 Day Day NNP cord-298503-l60cdllh 305 19 et et NNP cord-298503-l60cdllh 305 20 al al NNP cord-298503-l60cdllh 305 21 . . . cord-298503-l60cdllh 305 22 2010 2010 CD cord-298503-l60cdllh 306 1 ; ; : cord-298503-l60cdllh 306 2 Winslow Winslow NNP cord-298503-l60cdllh 306 3 et et NNP cord-298503-l60cdllh 306 4 al al NNP cord-298503-l60cdllh 306 5 . . NNP cord-298503-l60cdllh 306 6 , , , cord-298503-l60cdllh 306 7 2010 2010 CD cord-298503-l60cdllh 306 8 ; ; : cord-298503-l60cdllh 306 9 Zoppino Zoppino NNP cord-298503-l60cdllh 306 10 et et NNP cord-298503-l60cdllh 306 11 al al NNP cord-298503-l60cdllh 306 12 . . NNP cord-298503-l60cdllh 306 13 , , , cord-298503-l60cdllh 306 14 2010 2010 CD cord-298503-l60cdllh 306 15 ; ; : cord-298503-l60cdllh 306 16 Huang Huang NNP cord-298503-l60cdllh 306 17 et et NNP cord-298503-l60cdllh 306 18 al al NNP cord-298503-l60cdllh 306 19 . . NNP cord-298503-l60cdllh 306 20 , , , cord-298503-l60cdllh 306 21 2011 2011 CD cord-298503-l60cdllh 307 1 ; ; : cord-298503-l60cdllh 307 2 Lipatova Lipatova NNP cord-298503-l60cdllh 307 3 et et NNP cord-298503-l60cdllh 307 4 al al NNP cord-298503-l60cdllh 307 5 . . NNP cord-298503-l60cdllh 307 6 , , , cord-298503-l60cdllh 307 7 2012 2012 CD cord-298503-l60cdllh 307 8 ) ) -RRB- cord-298503-l60cdllh 307 9 . . . cord-298503-l60cdllh 308 1 A a DT cord-298503-l60cdllh 308 2 phosphatidylinositol phosphatidylinositol JJ cord-298503-l60cdllh 308 3 3-phosphatase 3-phosphatase CD cord-298503-l60cdllh 308 4 ( ( -LRB- cord-298503-l60cdllh 308 5 MTMR6 MTMR6 NNS cord-298503-l60cdllh 308 6 ) ) -RRB- cord-298503-l60cdllh 308 7 acting act VBG cord-298503-l60cdllh 308 8 in in IN cord-298503-l60cdllh 308 9 vesicle vesicle NN cord-298503-l60cdllh 308 10 transport transport NN cord-298503-l60cdllh 308 11 and and CC cord-298503-l60cdllh 308 12 autophagy autophagy NN cord-298503-l60cdllh 308 13 is be VBZ cord-298503-l60cdllh 308 14 regulated regulate VBN cord-298503-l60cdllh 308 15 by by IN cord-298503-l60cdllh 308 16 Rab1B Rab1B NNS cord-298503-l60cdllh 308 17 and and CC cord-298503-l60cdllh 308 18 localizes localize VBZ cord-298503-l60cdllh 308 19 predominantly predominantly RB cord-298503-l60cdllh 308 20 to to IN cord-298503-l60cdllh 308 21 the the DT cord-298503-l60cdllh 308 22 pcIC pcic NN cord-298503-l60cdllh 308 23 ( ( -LRB- cord-298503-l60cdllh 308 24 Mochizuki Mochizuki NNP cord-298503-l60cdllh 308 25 et et NNP cord-298503-l60cdllh 308 26 al al NNP cord-298503-l60cdllh 308 27 . . NNP cord-298503-l60cdllh 308 28 , , , cord-298503-l60cdllh 308 29 2013 2013 CD cord-298503-l60cdllh 308 30 ) ) -RRB- cord-298503-l60cdllh 308 31 , , , cord-298503-l60cdllh 308 32 further further RB cord-298503-l60cdllh 308 33 supporting support VBG cord-298503-l60cdllh 308 34 the the DT cord-298503-l60cdllh 308 35 role role NN cord-298503-l60cdllh 308 36 of of IN cord-298503-l60cdllh 308 37 the the DT cord-298503-l60cdllh 308 38 IC IC NNP cord-298503-l60cdllh 308 39 in in IN cord-298503-l60cdllh 308 40 autophagy autophagy NN cord-298503-l60cdllh 308 41 . . . cord-298503-l60cdllh 309 1 Supporting support VBG cord-298503-l60cdllh 309 2 the the DT cord-298503-l60cdllh 309 3 existence existence NN cord-298503-l60cdllh 309 4 of of IN cord-298503-l60cdllh 309 5 an an DT cord-298503-l60cdllh 309 6 unconventional unconventional JJ cord-298503-l60cdllh 309 7 pathway pathway NN cord-298503-l60cdllh 309 8 that that WDT cord-298503-l60cdllh 309 9 connects connect VBZ cord-298503-l60cdllh 309 10 the the DT cord-298503-l60cdllh 309 11 ER er NN cord-298503-l60cdllh 309 12 with with IN cord-298503-l60cdllh 309 13 the the DT cord-298503-l60cdllh 309 14 PM pm NN cord-298503-l60cdllh 309 15 - - HYPH cord-298503-l60cdllh 309 16 derived derive VBN cord-298503-l60cdllh 309 17 phagosome phagosome NN cord-298503-l60cdllh 309 18 ( ( -LRB- cord-298503-l60cdllh 309 19 Gagnon Gagnon NNP cord-298503-l60cdllh 309 20 et et NNP cord-298503-l60cdllh 309 21 al al NNP cord-298503-l60cdllh 309 22 . . NNP cord-298503-l60cdllh 309 23 , , , cord-298503-l60cdllh 309 24 2002 2002 CD cord-298503-l60cdllh 309 25 ) ) -RRB- cord-298503-l60cdllh 309 26 , , , cord-298503-l60cdllh 309 27 the the DT cord-298503-l60cdllh 309 28 IC IC NNP cord-298503-l60cdllh 309 29 - - HYPH cord-298503-l60cdllh 309 30 enriched enrich VBN cord-298503-l60cdllh 309 31 SNARE snare NN cord-298503-l60cdllh 310 1 Sec22B Sec22B NNP cord-298503-l60cdllh 310 2 / / SYM cord-298503-l60cdllh 310 3 ERS-24 ERS-24 NNP cord-298503-l60cdllh 311 1 ( ( -LRB- cord-298503-l60cdllh 311 2 Zhang Zhang NNP cord-298503-l60cdllh 311 3 et et NNP cord-298503-l60cdllh 311 4 al al NNP cord-298503-l60cdllh 311 5 . . NNP cord-298503-l60cdllh 311 6 , , , cord-298503-l60cdllh 311 7 1999 1999 CD cord-298503-l60cdllh 311 8 ) ) -RRB- cord-298503-l60cdllh 311 9 was be VBD cord-298503-l60cdllh 311 10 shown show VBN cord-298503-l60cdllh 311 11 to to TO cord-298503-l60cdllh 311 12 influence influence VB cord-298503-l60cdllh 311 13 phagocytosis phagocytosis NN cord-298503-l60cdllh 311 14 independently independently RB cord-298503-l60cdllh 311 15 of of IN cord-298503-l60cdllh 311 16 its -PRON- PRP$ cord-298503-l60cdllh 311 17 role role NN cord-298503-l60cdllh 311 18 in in IN cord-298503-l60cdllh 311 19 ER ER NNP cord-298503-l60cdllh 311 20 - - HYPH cord-298503-l60cdllh 311 21 Golgi golgi NN cord-298503-l60cdllh 311 22 trafficking trafficking NN cord-298503-l60cdllh 311 23 ( ( -LRB- cord-298503-l60cdllh 311 24 Becker Becker NNP cord-298503-l60cdllh 311 25 et et NNP cord-298503-l60cdllh 311 26 al al NNP cord-298503-l60cdllh 311 27 . . . cord-298503-l60cdllh 312 1 , , , cord-298503-l60cdllh 312 2 2005 2005 CD cord-298503-l60cdllh 312 3 ; ; : cord-298503-l60cdllh 312 4 Hatsuzawa Hatsuzawa NNP cord-298503-l60cdllh 312 5 et et FW cord-298503-l60cdllh 312 6 al al NNP cord-298503-l60cdllh 312 7 . . NNP cord-298503-l60cdllh 312 8 , , , cord-298503-l60cdllh 312 9 2009 2009 CD cord-298503-l60cdllh 312 10 ) ) -RRB- cord-298503-l60cdllh 312 11 . . . cord-298503-l60cdllh 313 1 In in IN cord-298503-l60cdllh 313 2 dendritic dendritic JJ cord-298503-l60cdllh 313 3 cells cell NNS cord-298503-l60cdllh 313 4 the the DT cord-298503-l60cdllh 313 5 delivery delivery NN cord-298503-l60cdllh 313 6 of of IN cord-298503-l60cdllh 313 7 certain certain JJ cord-298503-l60cdllh 313 8 proteinssuch proteinssuch JJ cord-298503-l60cdllh 313 9 as as IN cord-298503-l60cdllh 313 10 the the DT cord-298503-l60cdllh 313 11 peptide peptide NN cord-298503-l60cdllh 313 12 transporter transporter NN cord-298503-l60cdllh 313 13 ( ( -LRB- cord-298503-l60cdllh 313 14 TAP TAP NNP cord-298503-l60cdllh 313 15 ) ) -RRB- cord-298503-l60cdllh 313 16 , , , cord-298503-l60cdllh 313 17 CR CR NNP cord-298503-l60cdllh 313 18 and and CC cord-298503-l60cdllh 313 19 tapasinfrom tapasinfrom NNP cord-298503-l60cdllh 313 20 ER ER NNP cord-298503-l60cdllh 313 21 to to IN cord-298503-l60cdllh 313 22 the the DT cord-298503-l60cdllh 313 23 phagosome phagosome NN cord-298503-l60cdllh 313 24 is be VBZ cord-298503-l60cdllh 313 25 required require VBN cord-298503-l60cdllh 313 26 for for IN cord-298503-l60cdllh 313 27 antigen antigen NN cord-298503-l60cdllh 313 28 cross cross JJ cord-298503-l60cdllh 313 29 - - NN cord-298503-l60cdllh 313 30 presentation presentation NN cord-298503-l60cdllh 313 31 . . . cord-298503-l60cdllh 314 1 This this DT cord-298503-l60cdllh 314 2 pathway pathway NN cord-298503-l60cdllh 314 3 depends depend VBZ cord-298503-l60cdllh 314 4 on on IN cord-298503-l60cdllh 314 5 the the DT cord-298503-l60cdllh 314 6 interaction interaction NN cord-298503-l60cdllh 314 7 between between IN cord-298503-l60cdllh 314 8 Sec22B Sec22B NNP cord-298503-l60cdllh 314 9 and and CC cord-298503-l60cdllh 314 10 the the DT cord-298503-l60cdllh 314 11 PM PM NNP cord-298503-l60cdllh 314 12 SNARE snare VB cord-298503-l60cdllh 314 13 syntaxin syntaxin NNP cord-298503-l60cdllh 314 14 4 4 CD cord-298503-l60cdllh 314 15 and and CC cord-298503-l60cdllh 314 16 involves involve VBZ cord-298503-l60cdllh 314 17 efficient efficient JJ cord-298503-l60cdllh 314 18 recruitment recruitment NN cord-298503-l60cdllh 314 19 of of IN cord-298503-l60cdllh 314 20 the the DT cord-298503-l60cdllh 314 21 integral integral JJ cord-298503-l60cdllh 314 22 IC IC NNP cord-298503-l60cdllh 314 23 components component NNS cord-298503-l60cdllh 314 24 sec22B sec22B NNP cord-298503-l60cdllh 314 25 and and CC cord-298503-l60cdllh 314 26 p58 p58 NNP cord-298503-l60cdllh 314 27 / / SYM cord-298503-l60cdllh 314 28 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 314 29 to to IN cord-298503-l60cdllh 314 30 the the DT cord-298503-l60cdllh 314 31 phagosomes phagosome NNS cord-298503-l60cdllh 314 32 ( ( -LRB- cord-298503-l60cdllh 314 33 Cebrian Cebrian NNP cord-298503-l60cdllh 314 34 et et NNP cord-298503-l60cdllh 314 35 al al NNP cord-298503-l60cdllh 314 36 . . NNP cord-298503-l60cdllh 314 37 , , , cord-298503-l60cdllh 314 38 2011 2011 CD cord-298503-l60cdllh 314 39 ) ) -RRB- cord-298503-l60cdllh 314 40 , , , cord-298503-l60cdllh 314 41 in in IN cord-298503-l60cdllh 314 42 accordance accordance NN cord-298503-l60cdllh 314 43 with with IN cord-298503-l60cdllh 314 44 the the DT cord-298503-l60cdllh 314 45 idea idea NN cord-298503-l60cdllh 314 46 that that IN cord-298503-l60cdllh 314 47 the the DT cord-298503-l60cdllh 314 48 IC IC NNP cord-298503-l60cdllh 314 49 provides provide VBZ cord-298503-l60cdllh 314 50 an an DT cord-298503-l60cdllh 314 51 important important JJ cord-298503-l60cdllh 314 52 membrane membrane NN cord-298503-l60cdllh 314 53 source source NN cord-298503-l60cdllh 314 54 for for IN cord-298503-l60cdllh 314 55 their -PRON- PRP$ cord-298503-l60cdllh 314 56 formation formation NN cord-298503-l60cdllh 314 57 . . . cord-298503-l60cdllh 315 1 The the DT cord-298503-l60cdllh 315 2 presence presence NN cord-298503-l60cdllh 315 3 of of IN cord-298503-l60cdllh 315 4 CR CR NNP cord-298503-l60cdllh 315 5 , , , cord-298503-l60cdllh 315 6 tapasin tapasin NNP cord-298503-l60cdllh 315 7 , , , cord-298503-l60cdllh 315 8 and and CC cord-298503-l60cdllh 315 9 functional functional JJ cord-298503-l60cdllh 315 10 TAP tap NN cord-298503-l60cdllh 315 11 in in IN cord-298503-l60cdllh 315 12 the the DT cord-298503-l60cdllh 315 13 IC IC NNP cord-298503-l60cdllh 315 14 / / SYM cord-298503-l60cdllh 315 15 cis cis NNP cord-298503-l60cdllh 315 16 - - HYPH cord-298503-l60cdllh 315 17 Golgi Golgi NNP cord-298503-l60cdllh 315 18 support support NN cord-298503-l60cdllh 315 19 this this DT cord-298503-l60cdllh 315 20 possibility possibility NN cord-298503-l60cdllh 315 21 ( ( -LRB- cord-298503-l60cdllh 315 22 Kleijmeer Kleijmeer NNP cord-298503-l60cdllh 315 23 et et NNP cord-298503-l60cdllh 315 24 al al NNP cord-298503-l60cdllh 315 25 . . NNP cord-298503-l60cdllh 315 26 , , , cord-298503-l60cdllh 315 27 1992 1992 CD cord-298503-l60cdllh 315 28 ; ; : cord-298503-l60cdllh 315 29 Howe Howe NNP cord-298503-l60cdllh 315 30 et et NNP cord-298503-l60cdllh 315 31 al al NNP cord-298503-l60cdllh 315 32 . . NNP cord-298503-l60cdllh 315 33 , , , cord-298503-l60cdllh 315 34 2009 2009 CD cord-298503-l60cdllh 315 35 ; ; : cord-298503-l60cdllh 315 36 Ghanem Ghanem NNP cord-298503-l60cdllh 315 37 et et NNP cord-298503-l60cdllh 315 38 al al NNP cord-298503-l60cdllh 315 39 . . NNP cord-298503-l60cdllh 315 40 , , , cord-298503-l60cdllh 315 41 2010 2010 CD cord-298503-l60cdllh 315 42 ) ) -RRB- cord-298503-l60cdllh 315 43 . . . cord-298503-l60cdllh 316 1 The the DT cord-298503-l60cdllh 316 2 IC IC NNP cord-298503-l60cdllh 316 3 plays play VBZ cord-298503-l60cdllh 316 4 a a DT cord-298503-l60cdllh 316 5 role role NN cord-298503-l60cdllh 316 6 in in IN cord-298503-l60cdllh 316 7 the the DT cord-298503-l60cdllh 316 8 Golgi Golgi NNP cord-298503-l60cdllh 316 9 - - HYPH cord-298503-l60cdllh 316 10 independent independent JJ cord-298503-l60cdllh 316 11 trafficking trafficking NN cord-298503-l60cdllh 316 12 of of IN cord-298503-l60cdllh 316 13 CFTR CFTR NNP cord-298503-l60cdllh 316 14 ( ( -LRB- cord-298503-l60cdllh 316 15 see see VB cord-298503-l60cdllh 316 16 above above RB cord-298503-l60cdllh 316 17 ) ) -RRB- cord-298503-l60cdllh 316 18 . . . cord-298503-l60cdllh 317 1 Mutations mutation NNS cord-298503-l60cdllh 317 2 in in IN cord-298503-l60cdllh 317 3 p58 p58 NNP cord-298503-l60cdllh 317 4 / / SYM cord-298503-l60cdllh 317 5 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 317 6 / / SYM cord-298503-l60cdllh 317 7 LMAN1 LMAN1 NNP cord-298503-l60cdllh 317 8 , , , cord-298503-l60cdllh 317 9 or or CC cord-298503-l60cdllh 317 10 its -PRON- PRP$ cord-298503-l60cdllh 317 11 partner partner NN cord-298503-l60cdllh 317 12 MCFD2 MCFD2 . cord-298503-l60cdllh 318 1 ( ( -LRB- cord-298503-l60cdllh 318 2 multiple multiple JJ cord-298503-l60cdllh 318 3 coagulation coagulation NN cord-298503-l60cdllh 318 4 factor factor NN cord-298503-l60cdllh 318 5 deficiency deficiency NN cord-298503-l60cdllh 318 6 protein protein NN cord-298503-l60cdllh 318 7 2 2 CD cord-298503-l60cdllh 318 8 ) ) -RRB- cord-298503-l60cdllh 318 9 result result VBP cord-298503-l60cdllh 318 10 in in IN cord-298503-l60cdllh 318 11 an an DT cord-298503-l60cdllh 318 12 autosomal autosomal JJ cord-298503-l60cdllh 318 13 recessive recessive JJ cord-298503-l60cdllh 318 14 bleeding bleed VBG cord-298503-l60cdllh 318 15 disorder disorder NN cord-298503-l60cdllh 318 16 called call VBN cord-298503-l60cdllh 318 17 combined combine VBN cord-298503-l60cdllh 318 18 deficiency deficiency NN cord-298503-l60cdllh 318 19 of of IN cord-298503-l60cdllh 318 20 coagulation coagulation NN cord-298503-l60cdllh 318 21 factors factor NNS cord-298503-l60cdllh 318 22 V v NN cord-298503-l60cdllh 318 23 and and CC cord-298503-l60cdllh 318 24 VIII VIII NNP cord-298503-l60cdllh 318 25 . . . cord-298503-l60cdllh 319 1 They -PRON- PRP cord-298503-l60cdllh 319 2 disrupt disrupt VBP cord-298503-l60cdllh 319 3 the the DT cord-298503-l60cdllh 319 4 lectin lectin NN cord-298503-l60cdllh 319 5 mannose mannose NN cord-298503-l60cdllh 319 6 - - HYPH cord-298503-l60cdllh 319 7 binding bind VBG cord-298503-l60cdllh 319 8 protein protein NN cord-298503-l60cdllh 319 9 1 1 CD cord-298503-l60cdllh 320 1 ( ( -LRB- cord-298503-l60cdllh 320 2 LMAN1)-MCFD2 lman1)-mcfd2 JJ cord-298503-l60cdllh 320 3 receptor receptor NN cord-298503-l60cdllh 320 4 complex complex NN cord-298503-l60cdllh 320 5 , , , cord-298503-l60cdllh 320 6 thereby thereby RB cord-298503-l60cdllh 320 7 inhibiting inhibit VBG cord-298503-l60cdllh 320 8 the the DT cord-298503-l60cdllh 320 9 secretion secretion NN cord-298503-l60cdllh 320 10 of of IN cord-298503-l60cdllh 320 11 these these DT cord-298503-l60cdllh 320 12 factors factor NNS cord-298503-l60cdllh 320 13 and and CC cord-298503-l60cdllh 320 14 reducing reduce VBG cord-298503-l60cdllh 320 15 their -PRON- PRP$ cord-298503-l60cdllh 320 16 serum serum NN cord-298503-l60cdllh 320 17 levels level NNS cord-298503-l60cdllh 320 18 ( ( -LRB- cord-298503-l60cdllh 320 19 Nichols Nichols NNP cord-298503-l60cdllh 320 20 et et NNP cord-298503-l60cdllh 320 21 al al NNP cord-298503-l60cdllh 320 22 . . NNP cord-298503-l60cdllh 320 23 , , , cord-298503-l60cdllh 320 24 1998 1998 CD cord-298503-l60cdllh 320 25 ; ; : cord-298503-l60cdllh 320 26 Zheng Zheng NNP cord-298503-l60cdllh 320 27 and and CC cord-298503-l60cdllh 320 28 Zhang Zhang NNP cord-298503-l60cdllh 320 29 , , , cord-298503-l60cdllh 320 30 2013 2013 CD cord-298503-l60cdllh 320 31 ) ) -RRB- cord-298503-l60cdllh 320 32 . . . cord-298503-l60cdllh 321 1 Parkinson Parkinson NNP cord-298503-l60cdllh 321 2 's 's POS cord-298503-l60cdllh 321 3 disease disease NN cord-298503-l60cdllh 321 4 - - HYPH cord-298503-l60cdllh 321 5 related relate VBN cord-298503-l60cdllh 321 6 cytotoxic cytotoxic JJ cord-298503-l60cdllh 321 7 protein protein NN cord-298503-l60cdllh 321 8 , , , cord-298503-l60cdllh 321 9 α α NN cord-298503-l60cdllh 321 10 - - HYPH cord-298503-l60cdllh 321 11 synuclein synuclein NNP cord-298503-l60cdllh 321 12 , , , cord-298503-l60cdllh 321 13 has have VBZ cord-298503-l60cdllh 321 14 been be VBN cord-298503-l60cdllh 321 15 suggested suggest VBN cord-298503-l60cdllh 321 16 to to TO cord-298503-l60cdllh 321 17 interfere interfere VB cord-298503-l60cdllh 321 18 with with IN cord-298503-l60cdllh 321 19 ER ER NNP cord-298503-l60cdllh 321 20 - - HYPH cord-298503-l60cdllh 321 21 Golgi Golgi NNP cord-298503-l60cdllh 321 22 trafficking trafficking NN cord-298503-l60cdllh 321 23 and and CC cord-298503-l60cdllh 321 24 to to TO cord-298503-l60cdllh 321 25 arrest arrest VB cord-298503-l60cdllh 321 26 autophagy autophagy NN cord-298503-l60cdllh 321 27 by by IN cord-298503-l60cdllh 321 28 inhibiting inhibit VBG cord-298503-l60cdllh 321 29 Rab1 rab1 NN cord-298503-l60cdllh 321 30 function function NN cord-298503-l60cdllh 321 31 ( ( -LRB- cord-298503-l60cdllh 321 32 Cooper Cooper NNP cord-298503-l60cdllh 321 33 et et NNP cord-298503-l60cdllh 321 34 al al NNP cord-298503-l60cdllh 321 35 . . NNP cord-298503-l60cdllh 321 36 , , , cord-298503-l60cdllh 321 37 2006 2006 CD cord-298503-l60cdllh 321 38 ; ; : cord-298503-l60cdllh 321 39 Winslow Winslow NNP cord-298503-l60cdllh 321 40 et et NNP cord-298503-l60cdllh 321 41 al al NNP cord-298503-l60cdllh 321 42 . . NNP cord-298503-l60cdllh 321 43 , , , cord-298503-l60cdllh 321 44 2010 2010 CD cord-298503-l60cdllh 321 45 ) ) -RRB- cord-298503-l60cdllh 321 46 . . . cord-298503-l60cdllh 322 1 Many many JJ cord-298503-l60cdllh 322 2 phagocytosed phagocytose VBN cord-298503-l60cdllh 322 3 bacterial bacterial JJ cord-298503-l60cdllh 322 4 pathogens pathogen NNS cord-298503-l60cdllh 322 5 , , , cord-298503-l60cdllh 322 6 such such JJ cord-298503-l60cdllh 322 7 as as IN cord-298503-l60cdllh 322 8 Legionella Legionella NNP cord-298503-l60cdllh 322 9 , , , cord-298503-l60cdllh 322 10 hijack hijack VB cord-298503-l60cdllh 322 11 the the DT cord-298503-l60cdllh 322 12 ER er NN cord-298503-l60cdllh 322 13 - - HYPH cord-298503-l60cdllh 322 14 to to IN cord-298503-l60cdllh 322 15 - - HYPH cord-298503-l60cdllh 322 16 IC ic NN cord-298503-l60cdllh 322 17 - - HYPH cord-298503-l60cdllh 322 18 to to IN cord-298503-l60cdllh 322 19 - - HYPH cord-298503-l60cdllh 322 20 phagosome phagosome NN cord-298503-l60cdllh 322 21 pathway pathway NN cord-298503-l60cdllh 322 22 during during IN cord-298503-l60cdllh 322 23 their -PRON- PRP$ cord-298503-l60cdllh 322 24 intracellular intracellular JJ cord-298503-l60cdllh 322 25 replication replication NN cord-298503-l60cdllh 322 26 ( ( -LRB- cord-298503-l60cdllh 322 27 Isberg Isberg NNP cord-298503-l60cdllh 322 28 et et NNP cord-298503-l60cdllh 322 29 al al NNP cord-298503-l60cdllh 322 30 . . NNP cord-298503-l60cdllh 322 31 , , , cord-298503-l60cdllh 322 32 2009 2009 CD cord-298503-l60cdllh 322 33 ; ; . cord-298503-l60cdllh 323 1 Arasaki Arasaki NNP cord-298503-l60cdllh 323 2 et et NNP cord-298503-l60cdllh 323 3 al al NNP cord-298503-l60cdllh 323 4 . . NNP cord-298503-l60cdllh 323 5 , , , cord-298503-l60cdllh 323 6 2012 2012 CD cord-298503-l60cdllh 323 7 ; ; : cord-298503-l60cdllh 323 8 see see VB cord-298503-l60cdllh 323 9 above above RB cord-298503-l60cdllh 323 10 ) ) -RRB- cord-298503-l60cdllh 323 11 . . . cord-298503-l60cdllh 324 1 In in IN cord-298503-l60cdllh 324 2 addition addition NN cord-298503-l60cdllh 324 3 to to IN cord-298503-l60cdllh 324 4 coronaviruses coronaviruse NNS cord-298503-l60cdllh 324 5 , , , cord-298503-l60cdllh 324 6 the the DT cord-298503-l60cdllh 324 7 IC IC NNP cord-298503-l60cdllh 324 8 has have VBZ cord-298503-l60cdllh 324 9 been be VBN cord-298503-l60cdllh 324 10 implicated implicate VBN cord-298503-l60cdllh 324 11 in in IN cord-298503-l60cdllh 324 12 the the DT cord-298503-l60cdllh 324 13 replication replication NN cord-298503-l60cdllh 324 14 of of IN cord-298503-l60cdllh 324 15 bunya- bunya- NN cord-298503-l60cdllh 324 16 , , , cord-298503-l60cdllh 324 17 entero- entero- NN cord-298503-l60cdllh 324 18 , , , cord-298503-l60cdllh 324 19 flavi- flavi- NN cord-298503-l60cdllh 324 20 , , , cord-298503-l60cdllh 324 21 picorna picorna NNP cord-298503-l60cdllh 324 22 , , , cord-298503-l60cdllh 324 23 and and CC cord-298503-l60cdllh 324 24 vacciniaviruses vacciniaviruse NNS cord-298503-l60cdllh 324 25 ( ( -LRB- cord-298503-l60cdllh 324 26 Jäntti Jäntti NNP cord-298503-l60cdllh 324 27 et et NNP cord-298503-l60cdllh 324 28 al al NNP cord-298503-l60cdllh 324 29 . . NNP cord-298503-l60cdllh 324 30 , , , cord-298503-l60cdllh 324 31 1997 1997 CD cord-298503-l60cdllh 324 32 ; ; : cord-298503-l60cdllh 324 33 Risco Risco NNP cord-298503-l60cdllh 324 34 et et NNP cord-298503-l60cdllh 324 35 al al NNP cord-298503-l60cdllh 324 36 . . NNP cord-298503-l60cdllh 324 37 , , , cord-298503-l60cdllh 324 38 2002 2002 CD cord-298503-l60cdllh 324 39 ; ; : cord-298503-l60cdllh 324 40 Miller Miller NNP cord-298503-l60cdllh 324 41 and and CC cord-298503-l60cdllh 324 42 Krijnse Krijnse NNP cord-298503-l60cdllh 324 43 - - HYPH cord-298503-l60cdllh 324 44 Locker Locker NNP cord-298503-l60cdllh 324 45 , , , cord-298503-l60cdllh 324 46 2008 2008 CD cord-298503-l60cdllh 324 47 ; ; : cord-298503-l60cdllh 324 48 Hsu Hsu NNP cord-298503-l60cdllh 324 49 et et NNP cord-298503-l60cdllh 324 50 al al NNP cord-298503-l60cdllh 324 51 . . NNP cord-298503-l60cdllh 324 52 , , , cord-298503-l60cdllh 324 53 2010 2010 CD cord-298503-l60cdllh 324 54 ) ) -RRB- cord-298503-l60cdllh 324 55 . . . cord-298503-l60cdllh 325 1 Surprisingly surprisingly RB cord-298503-l60cdllh 325 2 , , , cord-298503-l60cdllh 325 3 p58/ p58/ NNP cord-298503-l60cdllh 325 4 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 325 5 interacts interact VBZ cord-298503-l60cdllh 325 6 in in IN cord-298503-l60cdllh 325 7 a a DT cord-298503-l60cdllh 325 8 lectin lectin NN cord-298503-l60cdllh 325 9 - - HYPH cord-298503-l60cdllh 325 10 independent independent JJ cord-298503-l60cdllh 325 11 manner manner NN cord-298503-l60cdllh 325 12 with with IN cord-298503-l60cdllh 325 13 fusion fusion NN cord-298503-l60cdllh 325 14 proteins protein NNS cord-298503-l60cdllh 325 15 of of IN cord-298503-l60cdllh 325 16 a a DT cord-298503-l60cdllh 325 17 number number NN cord-298503-l60cdllh 325 18 of of IN cord-298503-l60cdllh 325 19 membrane membrane NN cord-298503-l60cdllh 325 20 viruses virus NNS cord-298503-l60cdllh 325 21 and and CC cord-298503-l60cdllh 325 22 participates participate VBZ cord-298503-l60cdllh 325 23 in in IN cord-298503-l60cdllh 325 24 different different JJ cord-298503-l60cdllh 325 25 stages stage NNS cord-298503-l60cdllh 325 26 of of IN cord-298503-l60cdllh 325 27 their -PRON- PRP$ cord-298503-l60cdllh 325 28 life life NN cord-298503-l60cdllh 325 29 cycle cycle NN cord-298503-l60cdllh 326 1 ( ( -LRB- cord-298503-l60cdllh 326 2 Klaus Klaus NNP cord-298503-l60cdllh 326 3 et et NNP cord-298503-l60cdllh 326 4 al al NNP cord-298503-l60cdllh 326 5 . . NNP cord-298503-l60cdllh 326 6 , , , cord-298503-l60cdllh 326 7 2013 2013 CD cord-298503-l60cdllh 326 8 ) ) -RRB- cord-298503-l60cdllh 326 9 . . . cord-298503-l60cdllh 326 10 _SP cord-298503-l60cdllh 327 1 Rab1 rab1 NN cord-298503-l60cdllh 327 2 recruitment recruitment NN cord-298503-l60cdllh 327 3 of of IN cord-298503-l60cdllh 327 4 p115 p115 NNS cord-298503-l60cdllh 327 5 into into IN cord-298503-l60cdllh 327 6 a a DT cord-298503-l60cdllh 327 7 cis cis JJ cord-298503-l60cdllh 327 8 - - HYPH cord-298503-l60cdllh 327 9 SNARE snare VB cord-298503-l60cdllh 327 10 complex complex NN cord-298503-l60cdllh 327 11 : : : cord-298503-l60cdllh 327 12 Programming programming NN cord-298503-l60cdllh 327 13 budding bud VBG cord-298503-l60cdllh 327 14 COPII COPII NNP cord-298503-l60cdllh 327 15 vesicles vesicle NNS cord-298503-l60cdllh 327 16 for for IN cord-298503-l60cdllh 327 17 fusion fusion NN cord-298503-l60cdllh 327 18 ER er NN cord-298503-l60cdllh 327 19 to to IN cord-298503-l60cdllh 327 20 Golgi Golgi NNP cord-298503-l60cdllh 327 21 transport transport NN cord-298503-l60cdllh 327 22 : : : cord-298503-l60cdllh 328 1 Requirement requirement NN cord-298503-l60cdllh 328 2 for for IN cord-298503-l60cdllh 328 3 p115 p115 NNS cord-298503-l60cdllh 328 4 at at IN cord-298503-l60cdllh 328 5 a a DT cord-298503-l60cdllh 328 6 pre pre JJ cord-298503-l60cdllh 328 7 - - JJ cord-298503-l60cdllh 328 8 Golgi golgi JJ cord-298503-l60cdllh 328 9 VTC VTC NNP cord-298503-l60cdllh 328 10 stage stage NN cord-298503-l60cdllh 328 11 COPI COPI NNP cord-298503-l60cdllh 328 12 recruitment recruitment NN cord-298503-l60cdllh 328 13 is be VBZ cord-298503-l60cdllh 328 14 modulated modulate VBN cord-298503-l60cdllh 328 15 by by IN cord-298503-l60cdllh 328 16 a a DT cord-298503-l60cdllh 328 17 Rab1b rab1b NN cord-298503-l60cdllh 328 18 - - HYPH cord-298503-l60cdllh 328 19 dependent dependent JJ cord-298503-l60cdllh 328 20 mechanism mechanism NN cord-298503-l60cdllh 328 21 The the DT cord-298503-l60cdllh 328 22 p115-interactive p115-interactive JJ cord-298503-l60cdllh 328 23 proteins protein NNS cord-298503-l60cdllh 328 24 GM130 GM130 NNP cord-298503-l60cdllh 328 25 and and CC cord-298503-l60cdllh 328 26 giantin giantin NNP cord-298503-l60cdllh 328 27 participate participate VBP cord-298503-l60cdllh 328 28 in in IN cord-298503-l60cdllh 328 29 endoplasmic endoplasmic JJ cord-298503-l60cdllh 328 30 reticulum reticulum NN cord-298503-l60cdllh 328 31 - - : cord-298503-l60cdllh 328 32 Golgi Golgi NNP cord-298503-l60cdllh 328 33 traffic traffic NN cord-298503-l60cdllh 328 34 Protein Protein NNP cord-298503-l60cdllh 328 35 quality quality NN cord-298503-l60cdllh 328 36 control control NN cord-298503-l60cdllh 328 37 in in IN cord-298503-l60cdllh 328 38 the the DT cord-298503-l60cdllh 328 39 early early JJ cord-298503-l60cdllh 328 40 secretory secretory JJ cord-298503-l60cdllh 328 41 pathway pathway NN cord-298503-l60cdllh 328 42 The the DT cord-298503-l60cdllh 328 43 lectin lectin NN cord-298503-l60cdllh 328 44 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 328 45 is be VBZ cord-298503-l60cdllh 328 46 a a DT cord-298503-l60cdllh 328 47 cargo cargo NN cord-298503-l60cdllh 328 48 transport transport NN cord-298503-l60cdllh 328 49 receptor receptor NN cord-298503-l60cdllh 328 50 for for IN cord-298503-l60cdllh 328 51 glycoproteins glycoprotein NNS cord-298503-l60cdllh 329 1 The the DT cord-298503-l60cdllh 329 2 ER ER NNP cord-298503-l60cdllh 329 3 - - HYPH cord-298503-l60cdllh 329 4 Golgi Golgi NNP cord-298503-l60cdllh 329 5 intermediate intermediate JJ cord-298503-l60cdllh 329 6 compartment compartment NN cord-298503-l60cdllh 329 7 ( ( -LRB- cord-298503-l60cdllh 329 8 ERGIC ERGIC NNP cord-298503-l60cdllh 329 9 ) ) -RRB- cord-298503-l60cdllh 329 10 : : : cord-298503-l60cdllh 329 11 In in IN cord-298503-l60cdllh 329 12 search search NN cord-298503-l60cdllh 329 13 of of IN cord-298503-l60cdllh 329 14 its -PRON- PRP$ cord-298503-l60cdllh 329 15 identity identity NN cord-298503-l60cdllh 329 16 and and CC cord-298503-l60cdllh 329 17 function function VB cord-298503-l60cdllh 329 18 pH ph NN cord-298503-l60cdllh 329 19 - - HYPH cord-298503-l60cdllh 329 20 induced induce VBN cord-298503-l60cdllh 329 21 conversion conversion NN cord-298503-l60cdllh 329 22 of of IN cord-298503-l60cdllh 329 23 the the DT cord-298503-l60cdllh 329 24 transport transport NN cord-298503-l60cdllh 329 25 lectin lectin NN cord-298503-l60cdllh 329 26 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 329 27 triggers trigger NNS cord-298503-l60cdllh 329 28 glycoprotein glycoprotein NN cord-298503-l60cdllh 329 29 release release NN cord-298503-l60cdllh 329 30 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 329 31 , , , cord-298503-l60cdllh 329 32 a a DT cord-298503-l60cdllh 329 33 membrane membrane NN cord-298503-l60cdllh 329 34 protein protein NN cord-298503-l60cdllh 329 35 of of IN cord-298503-l60cdllh 329 36 the the DT cord-298503-l60cdllh 329 37 endoplasmic endoplasmic NN cord-298503-l60cdllh 329 38 reticulum reticulum NN cord-298503-l60cdllh 329 39 - - : cord-298503-l60cdllh 329 40 Golgi Golgi NNP cord-298503-l60cdllh 329 41 intermediate intermediate JJ cord-298503-l60cdllh 329 42 compartment compartment NN cord-298503-l60cdllh 329 43 , , , cord-298503-l60cdllh 329 44 is be VBZ cord-298503-l60cdllh 329 45 identical identical JJ cord-298503-l60cdllh 329 46 to to IN cord-298503-l60cdllh 329 47 MR60 MR60 NNP cord-298503-l60cdllh 329 48 , , , cord-298503-l60cdllh 329 49 an an DT cord-298503-l60cdllh 329 50 intracellular intracellular JJ cord-298503-l60cdllh 329 51 mannose mannose NN cord-298503-l60cdllh 329 52 - - HYPH cord-298503-l60cdllh 329 53 specific specific JJ cord-298503-l60cdllh 329 54 lectin lectin NN cord-298503-l60cdllh 329 55 of of IN cord-298503-l60cdllh 329 56 myelomonocytic myelomonocytic JJ cord-298503-l60cdllh 329 57 cells cell NNS cord-298503-l60cdllh 330 1 The the DT cord-298503-l60cdllh 330 2 Legionella Legionella NNP cord-298503-l60cdllh 330 3 pneumophila pneumophila NN cord-298503-l60cdllh 330 4 effector effector NN cord-298503-l60cdllh 330 5 DrrA DrrA NNP cord-298503-l60cdllh 330 6 is be VBZ cord-298503-l60cdllh 330 7 sufficient sufficient JJ cord-298503-l60cdllh 330 8 to to TO cord-298503-l60cdllh 330 9 stimulate stimulate VB cord-298503-l60cdllh 330 10 SNARE snare NN cord-298503-l60cdllh 330 11 - - HYPH cord-298503-l60cdllh 330 12 dependent dependent JJ cord-298503-l60cdllh 330 13 membrane membrane NN cord-298503-l60cdllh 330 14 fusion fusion NN cord-298503-l60cdllh 330 15 Principles principle NNS cord-298503-l60cdllh 330 16 of of IN cord-298503-l60cdllh 330 17 selective selective JJ cord-298503-l60cdllh 330 18 transport transport NN cord-298503-l60cdllh 330 19 : : : cord-298503-l60cdllh 330 20 Coat coat NN cord-298503-l60cdllh 330 21 complexes complex NNS cord-298503-l60cdllh 330 22 hold hold VBP cord-298503-l60cdllh 330 23 the the DT cord-298503-l60cdllh 330 24 key key JJ cord-298503-l60cdllh 330 25 Phosphorylation Phosphorylation NNP cord-298503-l60cdllh 330 26 of of IN cord-298503-l60cdllh 330 27 two two CD cord-298503-l60cdllh 330 28 small small JJ cord-298503-l60cdllh 330 29 GTP gtp NN cord-298503-l60cdllh 330 30 - - HYPH cord-298503-l60cdllh 330 31 binding bind VBG cord-298503-l60cdllh 330 32 proteins protein NNS cord-298503-l60cdllh 330 33 of of IN cord-298503-l60cdllh 330 34 the the DT cord-298503-l60cdllh 330 35 Rab Rab NNP cord-298503-l60cdllh 330 36 family family NN cord-298503-l60cdllh 330 37 by by IN cord-298503-l60cdllh 330 38 p34 p34 NNP cord-298503-l60cdllh 330 39 cdc2 cdc2 NNP cord-298503-l60cdllh 330 40 ATP ATP NNP cord-298503-l60cdllh 330 41 - - HYPH cord-298503-l60cdllh 330 42 coupled couple VBN cord-298503-l60cdllh 330 43 transport transport NN cord-298503-l60cdllh 330 44 of of IN cord-298503-l60cdllh 330 45 vesicular vesicular JJ cord-298503-l60cdllh 330 46 stomatitis stomatitis NN cord-298503-l60cdllh 330 47 virus virus NN cord-298503-l60cdllh 330 48 G g NN cord-298503-l60cdllh 330 49 protein protein NN cord-298503-l60cdllh 330 50 between between IN cord-298503-l60cdllh 330 51 the the DT cord-298503-l60cdllh 330 52 endoplasmic endoplasmic NN cord-298503-l60cdllh 330 53 reticulum reticulum NN cord-298503-l60cdllh 330 54 and and CC cord-298503-l60cdllh 330 55 Golgi Golgi NNP cord-298503-l60cdllh 330 56 Vesicular Vesicular NNP cord-298503-l60cdllh 330 57 stomatitis stomatitis NN cord-298503-l60cdllh 330 58 virus virus NN cord-298503-l60cdllh 330 59 glycoprotein glycoprotein NN cord-298503-l60cdllh 330 60 is be VBZ cord-298503-l60cdllh 330 61 sorted sort VBN cord-298503-l60cdllh 330 62 and and CC cord-298503-l60cdllh 330 63 concentrated concentrate VBN cord-298503-l60cdllh 330 64 during during IN cord-298503-l60cdllh 330 65 export export NN cord-298503-l60cdllh 330 66 from from IN cord-298503-l60cdllh 330 67 the the DT cord-298503-l60cdllh 330 68 endoplasmic endoplasmic NN cord-298503-l60cdllh 330 69 reticulum reticulum NN cord-298503-l60cdllh 330 70 Membrane Membrane NNP cord-298503-l60cdllh 330 71 dynamics dynamic NNS cord-298503-l60cdllh 330 72 at at IN cord-298503-l60cdllh 330 73 the the DT cord-298503-l60cdllh 330 74 endoplasmic endoplasmic NN cord-298503-l60cdllh 330 75 reticulum reticulum NN cord-298503-l60cdllh 330 76 - - : cord-298503-l60cdllh 330 77 Golgi golgi NN cord-298503-l60cdllh 330 78 interface interface NN cord-298503-l60cdllh 331 1 The the DT cord-298503-l60cdllh 331 2 organization organization NN cord-298503-l60cdllh 331 3 of of IN cord-298503-l60cdllh 331 4 endoplasmic endoplasmic NN cord-298503-l60cdllh 331 5 reticulum reticulum NN cord-298503-l60cdllh 331 6 export export NN cord-298503-l60cdllh 331 7 complexes complex NNS cord-298503-l60cdllh 331 8 Secretory secretory JJ cord-298503-l60cdllh 331 9 protein protein NN cord-298503-l60cdllh 331 10 biogenesis biogenesis NN cord-298503-l60cdllh 331 11 and and CC cord-298503-l60cdllh 331 12 traffic traffic NN cord-298503-l60cdllh 331 13 in in IN cord-298503-l60cdllh 331 14 the the DT cord-298503-l60cdllh 331 15 early early JJ cord-298503-l60cdllh 331 16 secretory secretory JJ cord-298503-l60cdllh 331 17 pathway pathway NN cord-298503-l60cdllh 331 18 Rab Rab NNP cord-298503-l60cdllh 331 19 proteins protein NNS cord-298503-l60cdllh 331 20 and and CC cord-298503-l60cdllh 331 21 their -PRON- PRP$ cord-298503-l60cdllh 331 22 interaction interaction NN cord-298503-l60cdllh 331 23 partners partner NNS cord-298503-l60cdllh 331 24 The the DT cord-298503-l60cdllh 331 25 COPI COPI NNP cord-298503-l60cdllh 331 26 system system NN cord-298503-l60cdllh 331 27 : : : cord-298503-l60cdllh 331 28 Molecular molecular JJ cord-298503-l60cdllh 331 29 mechanisms mechanism NNS cord-298503-l60cdllh 331 30 and and CC cord-298503-l60cdllh 331 31 function function VB cord-298503-l60cdllh 331 32 Differential differential JJ cord-298503-l60cdllh 331 33 use use NN cord-298503-l60cdllh 331 34 of of IN cord-298503-l60cdllh 331 35 endoplasmic endoplasmic NN cord-298503-l60cdllh 331 36 reticulum reticulum NN cord-298503-l60cdllh 331 37 membrane membrane NN cord-298503-l60cdllh 331 38 for for IN cord-298503-l60cdllh 331 39 phagocytosis phagocytosis NN cord-298503-l60cdllh 331 40 in in IN cord-298503-l60cdllh 331 41 J774 J774 NNS cord-298503-l60cdllh 331 42 macrophages macrophage NNS cord-298503-l60cdllh 332 1 ADP ADP NNP cord-298503-l60cdllh 332 2 ribosylation ribosylation NN cord-298503-l60cdllh 332 3 factors factor VBZ cord-298503-l60cdllh 332 4 1 1 CD cord-298503-l60cdllh 332 5 and and CC cord-298503-l60cdllh 332 6 4 4 CD cord-298503-l60cdllh 332 7 and and CC cord-298503-l60cdllh 332 8 group group NN cord-298503-l60cdllh 332 9 VIA VIA NNP cord-298503-l60cdllh 332 10 phospholipase phospholipase NN cord-298503-l60cdllh 333 1 A a DT cord-298503-l60cdllh 333 2 2 2 CD cord-298503-l60cdllh 333 3 regulate regulate VBP cord-298503-l60cdllh 333 4 morphology morphology NN cord-298503-l60cdllh 333 5 and and CC cord-298503-l60cdllh 333 6 intraorganellar intraorganellar JJ cord-298503-l60cdllh 333 7 traffic traffic NN cord-298503-l60cdllh 333 8 in in IN cord-298503-l60cdllh 333 9 the the DT cord-298503-l60cdllh 333 10 endoplasmic endoplasmic NN cord-298503-l60cdllh 333 11 reticulum reticulum NN cord-298503-l60cdllh 333 12 - - : cord-298503-l60cdllh 333 13 Golgi Golgi NNP cord-298503-l60cdllh 333 14 intermediate intermediate JJ cord-298503-l60cdllh 333 15 compartment compartment NN cord-298503-l60cdllh 333 16 Live live JJ cord-298503-l60cdllh 333 17 imaging imaging NN cord-298503-l60cdllh 333 18 of of IN cord-298503-l60cdllh 333 19 bidirectional bidirectional JJ cord-298503-l60cdllh 333 20 traffic traffic NN cord-298503-l60cdllh 333 21 from from IN cord-298503-l60cdllh 333 22 the the DT cord-298503-l60cdllh 333 23 ERGIC ERGIC NNP cord-298503-l60cdllh 333 24 Vesicular Vesicular NNP cord-298503-l60cdllh 333 25 calcium calcium NN cord-298503-l60cdllh 334 1 regulates regulate VBZ cord-298503-l60cdllh 334 2 coat coat NN cord-298503-l60cdllh 334 3 retention retention NN cord-298503-l60cdllh 334 4 , , , cord-298503-l60cdllh 334 5 fusogenicity fusogenicity NN cord-298503-l60cdllh 334 6 , , , cord-298503-l60cdllh 334 7 and and CC cord-298503-l60cdllh 334 8 size size NN cord-298503-l60cdllh 334 9 of of IN cord-298503-l60cdllh 334 10 pre pre JJ cord-298503-l60cdllh 334 11 - - JJ cord-298503-l60cdllh 334 12 Golgi golgi JJ cord-298503-l60cdllh 334 13 intermediates intermediate NNS cord-298503-l60cdllh 334 14 Intracellular Intracellular NNP cord-298503-l60cdllh 334 15 localization localization NN cord-298503-l60cdllh 334 16 and and CC cord-298503-l60cdllh 334 17 in in IN cord-298503-l60cdllh 334 18 vivo vivo NN cord-298503-l60cdllh 334 19 trafficking trafficking NN cord-298503-l60cdllh 334 20 of of IN cord-298503-l60cdllh 334 21 p24A p24A NNP cord-298503-l60cdllh 335 1 and and CC cord-298503-l60cdllh 335 2 p23 p23 NNP cord-298503-l60cdllh 335 3 Lumenal Lumenal NNP cord-298503-l60cdllh 335 4 targeted target VBD cord-298503-l60cdllh 335 5 GFP GFP NNP cord-298503-l60cdllh 335 6 , , , cord-298503-l60cdllh 335 7 used use VBN cord-298503-l60cdllh 335 8 as as IN cord-298503-l60cdllh 335 9 a a DT cord-298503-l60cdllh 335 10 marker marker NN cord-298503-l60cdllh 335 11 of of IN cord-298503-l60cdllh 335 12 soluble soluble JJ cord-298503-l60cdllh 335 13 cargo cargo NN cord-298503-l60cdllh 335 14 , , , cord-298503-l60cdllh 335 15 visualises visualise VBZ cord-298503-l60cdllh 335 16 rapid rapid JJ cord-298503-l60cdllh 335 17 ERGIC ERGIC NNP cord-298503-l60cdllh 335 18 to to IN cord-298503-l60cdllh 335 19 Golgi Golgi NNP cord-298503-l60cdllh 335 20 traffic traffic NN cord-298503-l60cdllh 335 21 by by IN cord-298503-l60cdllh 335 22 a a DT cord-298503-l60cdllh 335 23 tubulo tubulo JJ cord-298503-l60cdllh 335 24 - - HYPH cord-298503-l60cdllh 335 25 vesicular vesicular JJ cord-298503-l60cdllh 335 26 network network NN cord-298503-l60cdllh 335 27 Palmitylation Palmitylation NNP cord-298503-l60cdllh 335 28 of of IN cord-298503-l60cdllh 335 29 viral viral JJ cord-298503-l60cdllh 335 30 membrane membrane NN cord-298503-l60cdllh 335 31 glycoproteins glycoprotein NNS cord-298503-l60cdllh 335 32 takes take VBZ cord-298503-l60cdllh 335 33 place place NN cord-298503-l60cdllh 335 34 after after IN cord-298503-l60cdllh 335 35 exit exit NN cord-298503-l60cdllh 335 36 from from IN cord-298503-l60cdllh 335 37 the the DT cord-298503-l60cdllh 335 38 endoplasmic endoplasmic NN cord-298503-l60cdllh 335 39 reticulum reticulum NN cord-298503-l60cdllh 335 40 Organization Organization NNP cord-298503-l60cdllh 335 41 of of IN cord-298503-l60cdllh 335 42 the the DT cord-298503-l60cdllh 335 43 ER ER NNP cord-298503-l60cdllh 335 44 - - HYPH cord-298503-l60cdllh 335 45 Golgi Golgi NNP cord-298503-l60cdllh 335 46 interface interface NN cord-298503-l60cdllh 335 47 for for IN cord-298503-l60cdllh 335 48 membrane membrane NN cord-298503-l60cdllh 335 49 traffic traffic NN cord-298503-l60cdllh 335 50 control control NN cord-298503-l60cdllh 335 51 Proteomics Proteomics NNP cord-298503-l60cdllh 335 52 of of IN cord-298503-l60cdllh 335 53 endoplasmic endoplasmic NN cord-298503-l60cdllh 335 54 reticulum reticulum NN cord-298503-l60cdllh 335 55 - - : cord-298503-l60cdllh 335 56 Golgi Golgi NNP cord-298503-l60cdllh 335 57 intermediate intermediate JJ cord-298503-l60cdllh 335 58 compartment compartment NN cord-298503-l60cdllh 335 59 ( ( -LRB- cord-298503-l60cdllh 335 60 ERGIC ERGIC NNP cord-298503-l60cdllh 335 61 ) ) -RRB- cord-298503-l60cdllh 335 62 membranes membrane NNS cord-298503-l60cdllh 335 63 from from IN cord-298503-l60cdllh 335 64 brefeldin brefeldin NNP cord-298503-l60cdllh 336 1 A a LS cord-298503-l60cdllh 336 2 - - HYPH cord-298503-l60cdllh 336 3 treated treat VBN cord-298503-l60cdllh 336 4 HepG2 HepG2 NNP cord-298503-l60cdllh 336 5 cells cell NNS cord-298503-l60cdllh 336 6 identifies identify VBZ cord-298503-l60cdllh 336 7 ERGIC-32 ERGIC-32 NNP cord-298503-l60cdllh 336 8 , , , cord-298503-l60cdllh 336 9 a a DT cord-298503-l60cdllh 336 10 new new JJ cord-298503-l60cdllh 336 11 cycling cycling NN cord-298503-l60cdllh 336 12 protein protein NN cord-298503-l60cdllh 336 13 that that WDT cord-298503-l60cdllh 336 14 interacts interact VBZ cord-298503-l60cdllh 336 15 with with IN cord-298503-l60cdllh 336 16 human human JJ cord-298503-l60cdllh 336 17 Erv46 Erv46 NNP cord-298503-l60cdllh 336 18 Binding Binding NNP cord-298503-l60cdllh 336 19 and and CC cord-298503-l60cdllh 336 20 endocytosis endocytosis NN cord-298503-l60cdllh 336 21 of of IN cord-298503-l60cdllh 336 22 39 39 CD cord-298503-l60cdllh 336 23 kDa kda NN cord-298503-l60cdllh 336 24 protein protein NN cord-298503-l60cdllh 336 25 by by IN cord-298503-l60cdllh 336 26 MDBK MDBK NNP cord-298503-l60cdllh 336 27 cells cell NNS cord-298503-l60cdllh 337 1 Overexpression overexpression NN cord-298503-l60cdllh 337 2 of of IN cord-298503-l60cdllh 337 3 the the DT cord-298503-l60cdllh 337 4 dynamitin dynamitin NNP cord-298503-l60cdllh 337 5 ( ( -LRB- cord-298503-l60cdllh 337 6 p50 p50 NN cord-298503-l60cdllh 337 7 ) ) -RRB- cord-298503-l60cdllh 337 8 subunit subunit NN cord-298503-l60cdllh 337 9 of of IN cord-298503-l60cdllh 337 10 the the DT cord-298503-l60cdllh 337 11 dynactin dynactin NNP cord-298503-l60cdllh 337 12 complex complex NN cord-298503-l60cdllh 337 13 disrupts disrupt VBZ cord-298503-l60cdllh 337 14 dynein dynein NN cord-298503-l60cdllh 337 15 - - HYPH cord-298503-l60cdllh 337 16 dependent dependent JJ cord-298503-l60cdllh 337 17 maintenance maintenance NN cord-298503-l60cdllh 337 18 of of IN cord-298503-l60cdllh 337 19 membrane membrane NN cord-298503-l60cdllh 337 20 organelle organelle NN cord-298503-l60cdllh 337 21 distribution distribution NN cord-298503-l60cdllh 337 22 Coats coat NNS cord-298503-l60cdllh 337 23 , , , cord-298503-l60cdllh 337 24 tethers tether NNS cord-298503-l60cdllh 337 25 , , , cord-298503-l60cdllh 337 26 Rabs Rabs NNP cord-298503-l60cdllh 337 27 , , , cord-298503-l60cdllh 337 28 and and CC cord-298503-l60cdllh 337 29 SNAREs SNAREs NNP cord-298503-l60cdllh 337 30 work work VBP cord-298503-l60cdllh 337 31 together together RB cord-298503-l60cdllh 337 32 to to TO cord-298503-l60cdllh 337 33 mediate mediate VB cord-298503-l60cdllh 337 34 the the DT cord-298503-l60cdllh 337 35 intracellular intracellular JJ cord-298503-l60cdllh 337 36 destination destination NN cord-298503-l60cdllh 337 37 of of IN cord-298503-l60cdllh 338 1 a a DT cord-298503-l60cdllh 338 2 transport transport NN cord-298503-l60cdllh 338 3 vesicle vesicle NN cord-298503-l60cdllh 338 4 WHAMM WHAMM NNP cord-298503-l60cdllh 338 5 is be VBZ cord-298503-l60cdllh 338 6 an an DT cord-298503-l60cdllh 338 7 Arp2/3 Arp2/3 NNP cord-298503-l60cdllh 338 8 complex complex JJ cord-298503-l60cdllh 338 9 activator activator NN cord-298503-l60cdllh 338 10 that that WDT cord-298503-l60cdllh 338 11 binds bind VBZ cord-298503-l60cdllh 338 12 microtubules microtubule NNS cord-298503-l60cdllh 338 13 and and CC cord-298503-l60cdllh 338 14 functions function NNS cord-298503-l60cdllh 338 15 in in IN cord-298503-l60cdllh 338 16 ER ER NNP cord-298503-l60cdllh 338 17 to to IN cord-298503-l60cdllh 338 18 Golgi Golgi NNP cord-298503-l60cdllh 338 19 transport transport NN cord-298503-l60cdllh 338 20 Sec22b Sec22b NNP cord-298503-l60cdllh 338 21 regulates regulate VBZ cord-298503-l60cdllh 338 22 phagosomal phagosomal JJ cord-298503-l60cdllh 338 23 maturation maturation NN cord-298503-l60cdllh 338 24 and and CC cord-298503-l60cdllh 338 25 antigen antigen NN cord-298503-l60cdllh 338 26 crosspresentation crosspresentation NN cord-298503-l60cdllh 338 27 by by IN cord-298503-l60cdllh 338 28 dendritic dendritic JJ cord-298503-l60cdllh 338 29 cells cell NNS cord-298503-l60cdllh 338 30 SNARE snare VBP cord-298503-l60cdllh 338 31 membrane membrane NN cord-298503-l60cdllh 338 32 trafficking traffic VBG cord-298503-l60cdllh 338 33 dynamics dynamic NNS cord-298503-l60cdllh 338 34 in in IN cord-298503-l60cdllh 338 35 vivo vivo NNP cord-298503-l60cdllh 338 36 Localization localization NN cord-298503-l60cdllh 338 37 of of IN cord-298503-l60cdllh 338 38 low low JJ cord-298503-l60cdllh 338 39 molecular molecular JJ cord-298503-l60cdllh 338 40 weight weight NN cord-298503-l60cdllh 338 41 GTP GTP NNP cord-298503-l60cdllh 338 42 binding bind VBG cord-298503-l60cdllh 338 43 proteins protein NNS cord-298503-l60cdllh 338 44 to to IN cord-298503-l60cdllh 338 45 exocytic exocytic JJ cord-298503-l60cdllh 338 46 and and CC cord-298503-l60cdllh 338 47 endocytic endocytic JJ cord-298503-l60cdllh 338 48 compartments compartment NNS cord-298503-l60cdllh 339 1 Coatomer Coatomer NNP cord-298503-l60cdllh 339 2 - - HYPH cord-298503-l60cdllh 339 3 bound bind VBN cord-298503-l60cdllh 339 4 Cdc42 Cdc42 NNP cord-298503-l60cdllh 339 5 regulates regulate VBZ cord-298503-l60cdllh 339 6 dynein dynein JJ cord-298503-l60cdllh 339 7 recruitment recruitment NN cord-298503-l60cdllh 339 8 to to IN cord-298503-l60cdllh 339 9 COPI COPI NNP cord-298503-l60cdllh 339 10 vesicles vesicle NNS cord-298503-l60cdllh 339 11 Characterization characterization NN cord-298503-l60cdllh 339 12 of of IN cord-298503-l60cdllh 339 13 class class NN cord-298503-l60cdllh 339 14 I i NN cord-298503-l60cdllh 339 15 and and CC cord-298503-l60cdllh 339 16 class class NN cord-298503-l60cdllh 339 17 II II NNP cord-298503-l60cdllh 339 18 ADP adp NN cord-298503-l60cdllh 339 19 - - HYPH cord-298503-l60cdllh 339 20 ribosylation ribosylation NN cord-298503-l60cdllh 339 21 factors factor NNS cord-298503-l60cdllh 339 22 in in IN cord-298503-l60cdllh 339 23 live live JJ cord-298503-l60cdllh 339 24 cells cell NNS cord-298503-l60cdllh 339 25 : : : cord-298503-l60cdllh 340 1 GDP gdp NN cord-298503-l60cdllh 340 2 - - HYPH cord-298503-l60cdllh 340 3 bound bind VBN cord-298503-l60cdllh 340 4 class class NN cord-298503-l60cdllh 340 5 II II NNP cord-298503-l60cdllh 340 6 Arfs Arfs NNP cord-298503-l60cdllh 340 7 associate associate JJ cord-298503-l60cdllh 340 8 with with IN cord-298503-l60cdllh 340 9 the the DT cord-298503-l60cdllh 340 10 ER ER NNP cord-298503-l60cdllh 340 11 - - HYPH cord-298503-l60cdllh 340 12 Golgi Golgi NNP cord-298503-l60cdllh 340 13 intermediate intermediate JJ cord-298503-l60cdllh 340 14 compartment compartment NN cord-298503-l60cdllh 340 15 independently independently RB cord-298503-l60cdllh 340 16 of of IN cord-298503-l60cdllh 340 17 GBF1 GBF1 NNP cord-298503-l60cdllh 340 18 Golgi Golgi NNP cord-298503-l60cdllh 340 19 dispersal dispersal NN cord-298503-l60cdllh 340 20 during during IN cord-298503-l60cdllh 340 21 microtubule microtubule JJ cord-298503-l60cdllh 340 22 disruption disruption NN cord-298503-l60cdllh 340 23 : : : cord-298503-l60cdllh 340 24 Regeneration regeneration NN cord-298503-l60cdllh 340 25 of of IN cord-298503-l60cdllh 340 26 Golgi Golgi NNP cord-298503-l60cdllh 340 27 stacks stack NNS cord-298503-l60cdllh 340 28 at at IN cord-298503-l60cdllh 340 29 peripheral peripheral JJ cord-298503-l60cdllh 340 30 endoplasmic endoplasmic NN cord-298503-l60cdllh 340 31 reticulum reticulum NN cord-298503-l60cdllh 340 32 exit exit NN cord-298503-l60cdllh 340 33 sites site NNS cord-298503-l60cdllh 340 34 Transport Transport NNP cord-298503-l60cdllh 340 35 into into IN cord-298503-l60cdllh 340 36 and and CC cord-298503-l60cdllh 340 37 out out IN cord-298503-l60cdllh 340 38 of of IN cord-298503-l60cdllh 340 39 the the DT cord-298503-l60cdllh 340 40 Golgi Golgi NNP cord-298503-l60cdllh 340 41 complex complex NN cord-298503-l60cdllh 340 42 studied study VBN cord-298503-l60cdllh 340 43 by by IN cord-298503-l60cdllh 340 44 transfecting transfecte VBG cord-298503-l60cdllh 340 45 cells cell NNS cord-298503-l60cdllh 340 46 with with IN cord-298503-l60cdllh 340 47 cDNAs cdna NNS cord-298503-l60cdllh 340 48 encoding encode VBG cord-298503-l60cdllh 340 49 horseradish horseradish NN cord-298503-l60cdllh 340 50 peroxidase peroxidase NN cord-298503-l60cdllh 340 51 Alpha Alpha NNP cord-298503-l60cdllh 340 52 - - HYPH cord-298503-l60cdllh 340 53 synuclein synuclein NNP cord-298503-l60cdllh 340 54 blocks block NNS cord-298503-l60cdllh 340 55 ER ER NNP cord-298503-l60cdllh 340 56 - - HYPH cord-298503-l60cdllh 340 57 Golgi Golgi NNP cord-298503-l60cdllh 340 58 traffic traffic NN cord-298503-l60cdllh 340 59 and and CC cord-298503-l60cdllh 340 60 Rab1 rab1 NN cord-298503-l60cdllh 340 61 rescues rescue VBZ cord-298503-l60cdllh 340 62 neuron neuron NN cord-298503-l60cdllh 340 63 loss loss NN cord-298503-l60cdllh 340 64 in in IN cord-298503-l60cdllh 340 65 Parkinson Parkinson NNP cord-298503-l60cdllh 340 66 's 's POS cord-298503-l60cdllh 340 67 models model NNS cord-298503-l60cdllh 340 68 Coatomer Coatomer NNP cord-298503-l60cdllh 340 69 ( ( -LRB- cord-298503-l60cdllh 340 70 COPI)-coated copi)-coate VBN cord-298503-l60cdllh 340 71 vesicles vesicle NNS cord-298503-l60cdllh 340 72 : : : cord-298503-l60cdllh 340 73 Role role NN cord-298503-l60cdllh 340 74 in in IN cord-298503-l60cdllh 340 75 intracellular intracellular JJ cord-298503-l60cdllh 340 76 transport transport NN cord-298503-l60cdllh 340 77 and and CC cord-298503-l60cdllh 340 78 protein protein NN cord-298503-l60cdllh 340 79 sorting sort VBG cord-298503-l60cdllh 340 80 Quantitative quantitative JJ cord-298503-l60cdllh 340 81 ER ER NNP cord-298503-l60cdllh 340 82 2 2 CD cord-298503-l60cdllh 340 83 Golgi Golgi NNP cord-298503-l60cdllh 340 84 transport transport NN cord-298503-l60cdllh 340 85 kinetics kinetic NNS cord-298503-l60cdllh 340 86 and and CC cord-298503-l60cdllh 340 87 protein protein NN cord-298503-l60cdllh 340 88 separation separation NN cord-298503-l60cdllh 340 89 upon upon IN cord-298503-l60cdllh 340 90 Golgi Golgi NNP cord-298503-l60cdllh 340 91 exit exit NN cord-298503-l60cdllh 340 92 revealed reveal VBN cord-298503-l60cdllh 340 93 by by IN cord-298503-l60cdllh 340 94 vesicular vesicular JJ cord-298503-l60cdllh 340 95 integral integral JJ cord-298503-l60cdllh 340 96 membrane membrane NN cord-298503-l60cdllh 340 97 protein protein NN cord-298503-l60cdllh 340 98 36 36 CD cord-298503-l60cdllh 340 99 dynamics dynamic NNS cord-298503-l60cdllh 340 100 in in IN cord-298503-l60cdllh 340 101 live live JJ cord-298503-l60cdllh 340 102 cells cell NNS cord-298503-l60cdllh 341 1 A a DT cord-298503-l60cdllh 341 2 three three CD cord-298503-l60cdllh 341 3 - - HYPH cord-298503-l60cdllh 341 4 stage stage NN cord-298503-l60cdllh 341 5 model model NN cord-298503-l60cdllh 341 6 of of IN cord-298503-l60cdllh 341 7 Golgi Golgi NNP cord-298503-l60cdllh 341 8 structure structure NN cord-298503-l60cdllh 341 9 and and CC cord-298503-l60cdllh 341 10 function function VB cord-298503-l60cdllh 341 11 The the DT cord-298503-l60cdllh 341 12 coiled coil VBN cord-298503-l60cdllh 341 13 - - HYPH cord-298503-l60cdllh 341 14 coil coil NN cord-298503-l60cdllh 341 15 membrane membrane NN cord-298503-l60cdllh 341 16 protein protein NN cord-298503-l60cdllh 341 17 golgin-84 golgin-84 NNS cord-298503-l60cdllh 341 18 is be VBZ cord-298503-l60cdllh 341 19 a a DT cord-298503-l60cdllh 341 20 novel novel JJ cord-298503-l60cdllh 341 21 Rab Rab NNP cord-298503-l60cdllh 341 22 effector effector NN cord-298503-l60cdllh 341 23 required require VBN cord-298503-l60cdllh 341 24 for for IN cord-298503-l60cdllh 341 25 Golgi Golgi NNP cord-298503-l60cdllh 341 26 ribbon ribbon NN cord-298503-l60cdllh 341 27 formation formation NN cord-298503-l60cdllh 341 28 Phosphorylation Phosphorylation NNP cord-298503-l60cdllh 341 29 of of IN cord-298503-l60cdllh 341 30 arylsulphatase arylsulphatase NNP cord-298503-l60cdllh 341 31 A A NNP cord-298503-l60cdllh 341 32 occurs occur VBZ cord-298503-l60cdllh 341 33 through through IN cord-298503-l60cdllh 341 34 multiple multiple JJ cord-298503-l60cdllh 341 35 interactions interaction NNS cord-298503-l60cdllh 341 36 with with IN cord-298503-l60cdllh 341 37 the the DT cord-298503-l60cdllh 341 38 UDP UDP NNP cord-298503-l60cdllh 341 39 - - HYPH cord-298503-l60cdllh 341 40 N N NNP cord-298503-l60cdllh 341 41 - - HYPH cord-298503-l60cdllh 341 42 acetylglucosamine-1-phosphotransferase acetylglucosamine-1-phosphotransferase NNP cord-298503-l60cdllh 341 43 proximal proximal JJ cord-298503-l60cdllh 341 44 and and CC cord-298503-l60cdllh 341 45 distal distal JJ cord-298503-l60cdllh 341 46 to to IN cord-298503-l60cdllh 341 47 its -PRON- PRP$ cord-298503-l60cdllh 341 48 retrieval retrieval NN cord-298503-l60cdllh 341 49 site site NN cord-298503-l60cdllh 341 50 by by IN cord-298503-l60cdllh 341 51 the the DT cord-298503-l60cdllh 341 52 KDEL KDEL NNP cord-298503-l60cdllh 341 53 receptor receptor NN cord-298503-l60cdllh 342 1 gp25L gp25l LS cord-298503-l60cdllh 343 1 /emp24 /emp24 NFP cord-298503-l60cdllh 343 2 / / SYM cord-298503-l60cdllh 343 3 p24 p24 NN cord-298503-l60cdllh 343 4 protein protein NN cord-298503-l60cdllh 343 5 family family NN cord-298503-l60cdllh 343 6 members member NNS cord-298503-l60cdllh 343 7 of of IN cord-298503-l60cdllh 343 8 the the DT cord-298503-l60cdllh 343 9 cis cis NNP cord-298503-l60cdllh 343 10 - - HYPH cord-298503-l60cdllh 343 11 Golgi Golgi NNP cord-298503-l60cdllh 343 12 network network NN cord-298503-l60cdllh 343 13 bind bind VB cord-298503-l60cdllh 343 14 both both DT cord-298503-l60cdllh 343 15 COP cop NN cord-298503-l60cdllh 343 16 I I NNP cord-298503-l60cdllh 343 17 and and CC cord-298503-l60cdllh 343 18 II II NNP cord-298503-l60cdllh 343 19 coatomer coatomer NNP cord-298503-l60cdllh 343 20 Beta Beta NNP cord-298503-l60cdllh 343 21 - - HYPH cord-298503-l60cdllh 343 22 COP COP NNP cord-298503-l60cdllh 343 23 , , , cord-298503-l60cdllh 343 24 a a DT cord-298503-l60cdllh 343 25 110 110 CD cord-298503-l60cdllh 343 26 kd kd NNP cord-298503-l60cdllh 343 27 protein protein NN cord-298503-l60cdllh 343 28 associated associate VBN cord-298503-l60cdllh 343 29 with with IN cord-298503-l60cdllh 343 30 non non JJ cord-298503-l60cdllh 343 31 - - JJ cord-298503-l60cdllh 343 32 clathrin clathrin JJ cord-298503-l60cdllh 343 33 - - HYPH cord-298503-l60cdllh 343 34 coated coat VBN cord-298503-l60cdllh 343 35 vesicles vesicle NNS cord-298503-l60cdllh 343 36 and and CC cord-298503-l60cdllh 343 37 the the DT cord-298503-l60cdllh 343 38 Golgi Golgi NNP cord-298503-l60cdllh 343 39 complex complex NN cord-298503-l60cdllh 343 40 , , , cord-298503-l60cdllh 343 41 shows show VBZ cord-298503-l60cdllh 343 42 homology homology NN cord-298503-l60cdllh 343 43 to to IN cord-298503-l60cdllh 343 44 beta beta NN cord-298503-l60cdllh 343 45 - - HYPH cord-298503-l60cdllh 343 46 adaptin adaptin NNS cord-298503-l60cdllh 343 47 Differential Differential NNP cord-298503-l60cdllh 343 48 membrane membrane NN cord-298503-l60cdllh 343 49 association association NN cord-298503-l60cdllh 343 50 properties property NNS cord-298503-l60cdllh 343 51 and and CC cord-298503-l60cdllh 343 52 regulation regulation NN cord-298503-l60cdllh 343 53 of of IN cord-298503-l60cdllh 343 54 class class NN cord-298503-l60cdllh 343 55 I i NN cord-298503-l60cdllh 343 56 and and CC cord-298503-l60cdllh 343 57 class class NN cord-298503-l60cdllh 343 58 II ii NN cord-298503-l60cdllh 344 1 Arfs Arfs NNP cord-298503-l60cdllh 344 2 Dendritic Dendritic NNP cord-298503-l60cdllh 344 3 trafficking traffic VBG cord-298503-l60cdllh 344 4 for for IN cord-298503-l60cdllh 344 5 neuronal neuronal JJ cord-298503-l60cdllh 344 6 growth growth NN cord-298503-l60cdllh 344 7 and and CC cord-298503-l60cdllh 344 8 plasticity plasticity NN cord-298503-l60cdllh 345 1 The the DT cord-298503-l60cdllh 345 2 transmembrane transmembrane NN cord-298503-l60cdllh 345 3 protein protein NN cord-298503-l60cdllh 345 4 p25 p25 NN cord-298503-l60cdllh 345 5 forms form NNS cord-298503-l60cdllh 345 6 highly highly RB cord-298503-l60cdllh 345 7 specialized specialize VBN cord-298503-l60cdllh 345 8 domains domain NNS cord-298503-l60cdllh 345 9 that that WDT cord-298503-l60cdllh 345 10 regulate regulate VBP cord-298503-l60cdllh 345 11 membrane membrane NN cord-298503-l60cdllh 345 12 composition composition NN cord-298503-l60cdllh 345 13 and and CC cord-298503-l60cdllh 345 14 dynamics dynamic NNS cord-298503-l60cdllh 345 15 Ultrastructural Ultrastructural NNP cord-298503-l60cdllh 345 16 analysis analysis NN cord-298503-l60cdllh 345 17 of of IN cord-298503-l60cdllh 345 18 transitional transitional JJ cord-298503-l60cdllh 345 19 endoplasmic endoplasmic NN cord-298503-l60cdllh 345 20 reticulum reticulum NN cord-298503-l60cdllh 345 21 and and CC cord-298503-l60cdllh 345 22 pre pre JJ cord-298503-l60cdllh 345 23 - - JJ cord-298503-l60cdllh 345 24 Golgi golgi JJ cord-298503-l60cdllh 345 25 intermediates intermediate NNS cord-298503-l60cdllh 345 26 : : : cord-298503-l60cdllh 346 1 A a DT cord-298503-l60cdllh 346 2 highway highway NN cord-298503-l60cdllh 346 3 for for IN cord-298503-l60cdllh 346 4 cars car NNS cord-298503-l60cdllh 346 5 and and CC cord-298503-l60cdllh 346 6 trucks truck NNS cord-298503-l60cdllh 346 7 Signal signal NN cord-298503-l60cdllh 346 8 - - HYPH cord-298503-l60cdllh 346 9 dependent dependent JJ cord-298503-l60cdllh 346 10 export export NN cord-298503-l60cdllh 346 11 of of IN cord-298503-l60cdllh 346 12 GABA GABA NNP cord-298503-l60cdllh 346 13 transporter transporter NN cord-298503-l60cdllh 346 14 1 1 CD cord-298503-l60cdllh 346 15 from from IN cord-298503-l60cdllh 346 16 the the DT cord-298503-l60cdllh 346 17 ER ER NNP cord-298503-l60cdllh 346 18 - - HYPH cord-298503-l60cdllh 346 19 Golgi Golgi NNP cord-298503-l60cdllh 346 20 intermediate intermediate JJ cord-298503-l60cdllh 346 21 compartment compartment NN cord-298503-l60cdllh 346 22 is be VBZ cord-298503-l60cdllh 346 23 specified specify VBN cord-298503-l60cdllh 346 24 by by IN cord-298503-l60cdllh 346 25 a a DT cord-298503-l60cdllh 346 26 C c NN cord-298503-l60cdllh 346 27 - - HYPH cord-298503-l60cdllh 346 28 terminal terminal NN cord-298503-l60cdllh 346 29 motif motif NN cord-298503-l60cdllh 346 30 A a DT cord-298503-l60cdllh 346 31 putative putative JJ cord-298503-l60cdllh 346 32 novel novel JJ cord-298503-l60cdllh 346 33 class class NN cord-298503-l60cdllh 346 34 of of IN cord-298503-l60cdllh 346 35 animal animal NN cord-298503-l60cdllh 346 36 lectins lectin NNS cord-298503-l60cdllh 346 37 in in IN cord-298503-l60cdllh 346 38 the the DT cord-298503-l60cdllh 346 39 secretory secretory JJ cord-298503-l60cdllh 346 40 pathway pathway NN cord-298503-l60cdllh 346 41 homologous homologous JJ cord-298503-l60cdllh 346 42 to to IN cord-298503-l60cdllh 346 43 leguminous leguminous JJ cord-298503-l60cdllh 346 44 lectins lectin NNS cord-298503-l60cdllh 346 45 Osmium osmium NN cord-298503-l60cdllh 346 46 impregnation impregnation NN cord-298503-l60cdllh 346 47 of of IN cord-298503-l60cdllh 346 48 the the DT cord-298503-l60cdllh 346 49 Golgi Golgi NNP cord-298503-l60cdllh 346 50 apparatus apparatus NN cord-298503-l60cdllh 346 51 Characterization characterization NN cord-298503-l60cdllh 346 52 of of IN cord-298503-l60cdllh 346 53 brefeldin brefeldin NNP cord-298503-l60cdllh 346 54 A A NNP cord-298503-l60cdllh 346 55 - - HYPH cord-298503-l60cdllh 346 56 induced induce VBN cord-298503-l60cdllh 346 57 vesicular vesicular JJ cord-298503-l60cdllh 346 58 structures structure NNS cord-298503-l60cdllh 346 59 containing contain VBG cord-298503-l60cdllh 346 60 cycling cycling NN cord-298503-l60cdllh 346 61 proteins protein NNS cord-298503-l60cdllh 346 62 of of IN cord-298503-l60cdllh 346 63 the the DT cord-298503-l60cdllh 346 64 intermediate intermediate NNP cord-298503-l60cdllh 346 65 compartment compartment NNP cord-298503-l60cdllh 346 66 / / SYM cord-298503-l60cdllh 346 67 cis cis NNP cord-298503-l60cdllh 346 68 - - HYPH cord-298503-l60cdllh 346 69 Golgi Golgi NNP cord-298503-l60cdllh 346 70 network network NN cord-298503-l60cdllh 347 1 Endoplasmic Endoplasmic NNP cord-298503-l60cdllh 347 2 reticulummediated reticulummediate VBD cord-298503-l60cdllh 348 1 phagocytosis phagocytosis NN cord-298503-l60cdllh 348 2 is be VBZ cord-298503-l60cdllh 348 3 a a DT cord-298503-l60cdllh 348 4 mechanism mechanism NN cord-298503-l60cdllh 348 5 of of IN cord-298503-l60cdllh 348 6 entry entry NN cord-298503-l60cdllh 348 7 into into IN cord-298503-l60cdllh 349 1 macrophages macrophage NNS cord-298503-l60cdllh 349 2 ADP ADP NNP cord-298503-l60cdllh 349 3 - - HYPH cord-298503-l60cdllh 349 4 ribosylation ribosylation NN cord-298503-l60cdllh 349 5 factor factor NN cord-298503-l60cdllh 349 6 / / SYM cord-298503-l60cdllh 349 7 COPIdependent copidependent NN cord-298503-l60cdllh 349 8 events event NNS cord-298503-l60cdllh 349 9 at at IN cord-298503-l60cdllh 349 10 the the DT cord-298503-l60cdllh 349 11 endoplasmic endoplasmic NN cord-298503-l60cdllh 349 12 reticulum reticulum NN cord-298503-l60cdllh 349 13 - - : cord-298503-l60cdllh 349 14 Golgi Golgi NNP cord-298503-l60cdllh 349 15 interface interface NN cord-298503-l60cdllh 349 16 are be VBP cord-298503-l60cdllh 349 17 regulated regulate VBN cord-298503-l60cdllh 349 18 by by IN cord-298503-l60cdllh 349 19 the the DT cord-298503-l60cdllh 349 20 guanine guanine NN cord-298503-l60cdllh 349 21 nucleotide nucleotide JJ cord-298503-l60cdllh 349 22 exchange exchange NN cord-298503-l60cdllh 349 23 factor factor NN cord-298503-l60cdllh 349 24 GBF1 GBF1 NNP cord-298503-l60cdllh 350 1 The the DT cord-298503-l60cdllh 350 2 ER ER NNP cord-298503-l60cdllh 350 3 - - HYPH cord-298503-l60cdllh 350 4 Golgi Golgi NNP cord-298503-l60cdllh 350 5 intermediate intermediate JJ cord-298503-l60cdllh 350 6 compartment compartment NN cord-298503-l60cdllh 350 7 is be VBZ cord-298503-l60cdllh 350 8 a a DT cord-298503-l60cdllh 350 9 key key JJ cord-298503-l60cdllh 350 10 membrane membrane NN cord-298503-l60cdllh 350 11 source source NN cord-298503-l60cdllh 350 12 for for IN cord-298503-l60cdllh 350 13 the the DT cord-298503-l60cdllh 350 14 LC3 LC3 NNP cord-298503-l60cdllh 350 15 lipidation lipidation NN cord-298503-l60cdllh 350 16 step step NN cord-298503-l60cdllh 350 17 of of IN cord-298503-l60cdllh 350 18 autophagosome autophagosome NNP cord-298503-l60cdllh 350 19 biogenesis biogenesis NN cord-298503-l60cdllh 350 20 Rescue Rescue NNP cord-298503-l60cdllh 350 21 of of IN cord-298503-l60cdllh 350 22 ΔF508-CFTR ΔF508-CFTR VBG cord-298503-l60cdllh 350 23 trafficking trafficking NN cord-298503-l60cdllh 350 24 via via IN cord-298503-l60cdllh 350 25 a a DT cord-298503-l60cdllh 350 26 GRASP grasp NN cord-298503-l60cdllh 350 27 - - HYPH cord-298503-l60cdllh 350 28 dependent dependent JJ cord-298503-l60cdllh 350 29 unconventional unconventional JJ cord-298503-l60cdllh 350 30 secretion secretion NN cord-298503-l60cdllh 350 31 pathway pathway NN cord-298503-l60cdllh 351 1 The the DT cord-298503-l60cdllh 351 2 transporter transporter NN cord-298503-l60cdllh 351 3 associated associate VBN cord-298503-l60cdllh 351 4 with with IN cord-298503-l60cdllh 351 5 antigen antigen NN cord-298503-l60cdllh 351 6 processing processing NN cord-298503-l60cdllh 351 7 ( ( -LRB- cord-298503-l60cdllh 351 8 TAP tap NN cord-298503-l60cdllh 351 9 ) ) -RRB- cord-298503-l60cdllh 351 10 is be VBZ cord-298503-l60cdllh 351 11 active active JJ cord-298503-l60cdllh 351 12 in in IN cord-298503-l60cdllh 351 13 a a DT cord-298503-l60cdllh 351 14 post post JJ cord-298503-l60cdllh 351 15 - - JJ cord-298503-l60cdllh 351 16 ER er JJ cord-298503-l60cdllh 351 17 compartment compartment NN cord-298503-l60cdllh 352 1 Delta Delta NNP cord-298503-l60cdllh 352 2 F508 F508 NNP cord-298503-l60cdllh 352 3 CFTR CFTR NNP cord-298503-l60cdllh 352 4 localizes localize VBZ cord-298503-l60cdllh 352 5 in in IN cord-298503-l60cdllh 352 6 the the DT cord-298503-l60cdllh 352 7 endoplasmic endoplasmic NN cord-298503-l60cdllh 352 8 reticulum reticulum NN cord-298503-l60cdllh 352 9 - - : cord-298503-l60cdllh 352 10 Golgi Golgi NNP cord-298503-l60cdllh 352 11 intermediate intermediate JJ cord-298503-l60cdllh 352 12 compartment compartment NN cord-298503-l60cdllh 352 13 in in IN cord-298503-l60cdllh 352 14 cystic cystic JJ cord-298503-l60cdllh 352 15 fibrosis fibrosis NN cord-298503-l60cdllh 352 16 cells cell VBZ cord-298503-l60cdllh 352 17 Regulation regulation NN cord-298503-l60cdllh 352 18 of of IN cord-298503-l60cdllh 352 19 O o NN cord-298503-l60cdllh 352 20 - - HYPH cord-298503-l60cdllh 352 21 glycosylation glycosylation NN cord-298503-l60cdllh 352 22 through through IN cord-298503-l60cdllh 352 23 Golgi Golgi NNP cord-298503-l60cdllh 352 24 - - HYPH cord-298503-l60cdllh 352 25 to to IN cord-298503-l60cdllh 352 26 - - HYPH cord-298503-l60cdllh 352 27 ER er NN cord-298503-l60cdllh 352 28 relocation relocation NN cord-298503-l60cdllh 352 29 of of IN cord-298503-l60cdllh 352 30 initiation initiation NN cord-298503-l60cdllh 352 31 enzymes enzyme NNS cord-298503-l60cdllh 352 32 p24 p24 NN cord-298503-l60cdllh 352 33 and and CC cord-298503-l60cdllh 352 34 p23 p23 NN cord-298503-l60cdllh 352 35 , , , cord-298503-l60cdllh 352 36 the the DT cord-298503-l60cdllh 352 37 major major JJ cord-298503-l60cdllh 352 38 transmembrane transmembrane NN cord-298503-l60cdllh 352 39 proteins protein NNS cord-298503-l60cdllh 352 40 of of IN cord-298503-l60cdllh 352 41 COPI COPI NNP cord-298503-l60cdllh 352 42 - - HYPH cord-298503-l60cdllh 352 43 coated coat VBN cord-298503-l60cdllh 352 44 transport transport NN cord-298503-l60cdllh 352 45 vesicles vesicle NNS cord-298503-l60cdllh 352 46 , , , cord-298503-l60cdllh 352 47 form form VBP cord-298503-l60cdllh 352 48 heterooligomeric heterooligomeric JJ cord-298503-l60cdllh 352 49 complexes complex NNS cord-298503-l60cdllh 352 50 and and CC cord-298503-l60cdllh 352 51 cycle cycle VB cord-298503-l60cdllh 352 52 between between IN cord-298503-l60cdllh 352 53 the the DT cord-298503-l60cdllh 352 54 organelles organelle NNS cord-298503-l60cdllh 352 55 of of IN cord-298503-l60cdllh 352 56 the the DT cord-298503-l60cdllh 352 57 early early JJ cord-298503-l60cdllh 352 58 secretory secretory JJ cord-298503-l60cdllh 352 59 pathway pathway NN cord-298503-l60cdllh 352 60 Localization Localization NNP cord-298503-l60cdllh 352 61 of of IN cord-298503-l60cdllh 352 62 the the DT cord-298503-l60cdllh 352 63 Lys Lys NNP cord-298503-l60cdllh 352 64 , , , cord-298503-l60cdllh 352 65 Asp Asp NNP cord-298503-l60cdllh 352 66 , , , cord-298503-l60cdllh 352 67 Glu Glu NNP cord-298503-l60cdllh 352 68 , , , cord-298503-l60cdllh 352 69 Leu Leu NNP cord-298503-l60cdllh 352 70 tetrapeptide tetrapeptide NN cord-298503-l60cdllh 352 71 receptor receptor NN cord-298503-l60cdllh 352 72 to to IN cord-298503-l60cdllh 352 73 the the DT cord-298503-l60cdllh 352 74 Golgi Golgi NNP cord-298503-l60cdllh 352 75 complex complex NN cord-298503-l60cdllh 352 76 and and CC cord-298503-l60cdllh 352 77 the the DT cord-298503-l60cdllh 352 78 intermediate intermediate JJ cord-298503-l60cdllh 352 79 compartment compartment NN cord-298503-l60cdllh 352 80 in in IN cord-298503-l60cdllh 352 81 mammalian mammalian JJ cord-298503-l60cdllh 352 82 cells cell NNS cord-298503-l60cdllh 352 83 Immunocytochemical Immunocytochemical NNP cord-298503-l60cdllh 352 84 localization localization NN cord-298503-l60cdllh 352 85 of of IN cord-298503-l60cdllh 352 86 beta beta NN cord-298503-l60cdllh 352 87 - - HYPH cord-298503-l60cdllh 352 88 COP cop NN cord-298503-l60cdllh 352 89 to to IN cord-298503-l60cdllh 352 90 the the DT cord-298503-l60cdllh 352 91 ER ER NNP cord-298503-l60cdllh 352 92 - - HYPH cord-298503-l60cdllh 352 93 Golgi Golgi NNP cord-298503-l60cdllh 352 94 boundary boundary NN cord-298503-l60cdllh 352 95 and and CC cord-298503-l60cdllh 352 96 the the DT cord-298503-l60cdllh 352 97 TGN TGN NNP cord-298503-l60cdllh 352 98 Scyl1 Scyl1 NNS cord-298503-l60cdllh 352 99 scaffolds scaffold NNS cord-298503-l60cdllh 352 100 class class NN cord-298503-l60cdllh 352 101 II II NNP cord-298503-l60cdllh 352 102 Arfs Arfs NNP cord-298503-l60cdllh 352 103 to to IN cord-298503-l60cdllh 352 104 specific specific JJ cord-298503-l60cdllh 352 105 subcomplexes subcomplexe NNS cord-298503-l60cdllh 352 106 of of IN cord-298503-l60cdllh 352 107 coatomer coatomer NNP cord-298503-l60cdllh 352 108 through through IN cord-298503-l60cdllh 352 109 the the DT cord-298503-l60cdllh 352 110 γ γ NN cord-298503-l60cdllh 352 111 - - HYPH cord-298503-l60cdllh 352 112 COP cop NN cord-298503-l60cdllh 352 113 appendage appendage NN cord-298503-l60cdllh 352 114 domain domain NN cord-298503-l60cdllh 352 115 Dynamics dynamic NNS cord-298503-l60cdllh 352 116 of of IN cord-298503-l60cdllh 352 117 transitional transitional JJ cord-298503-l60cdllh 352 118 endoplasmic endoplasmic NN cord-298503-l60cdllh 352 119 reticulum reticulum NN cord-298503-l60cdllh 352 120 sites site NNS cord-298503-l60cdllh 352 121 in in IN cord-298503-l60cdllh 352 122 vertebrate vertebrate JJ cord-298503-l60cdllh 352 123 cells cell NNS cord-298503-l60cdllh 352 124 Quality quality NN cord-298503-l60cdllh 352 125 control control NN cord-298503-l60cdllh 352 126 in in IN cord-298503-l60cdllh 352 127 the the DT cord-298503-l60cdllh 352 128 secretory secretory JJ cord-298503-l60cdllh 352 129 pathway pathway NN cord-298503-l60cdllh 352 130 : : : cord-298503-l60cdllh 352 131 Retention Retention NNP cord-298503-l60cdllh 352 132 of of IN cord-298503-l60cdllh 352 133 a a DT cord-298503-l60cdllh 352 134 misfolded misfolde VBN cord-298503-l60cdllh 352 135 viral viral JJ cord-298503-l60cdllh 352 136 membrane membrane NN cord-298503-l60cdllh 352 137 glycoprotein glycoprotein NN cord-298503-l60cdllh 352 138 involves involve VBZ cord-298503-l60cdllh 352 139 cycling cycling NN cord-298503-l60cdllh 352 140 between between IN cord-298503-l60cdllh 352 141 the the DT cord-298503-l60cdllh 352 142 ER ER NNP cord-298503-l60cdllh 352 143 , , , cord-298503-l60cdllh 352 144 intermediate intermediate JJ cord-298503-l60cdllh 352 145 compartment compartment NN cord-298503-l60cdllh 352 146 , , , cord-298503-l60cdllh 352 147 and and CC cord-298503-l60cdllh 352 148 Golgi Golgi NNP cord-298503-l60cdllh 352 149 apparatus apparatus NN cord-298503-l60cdllh 352 150 Sec22b Sec22b NNP cord-298503-l60cdllh 352 151 is be VBZ cord-298503-l60cdllh 352 152 a a DT cord-298503-l60cdllh 352 153 negative negative JJ cord-298503-l60cdllh 352 154 regulator regulator NN cord-298503-l60cdllh 352 155 of of IN cord-298503-l60cdllh 352 156 phagocytosis phagocytosis NN cord-298503-l60cdllh 352 157 in in IN cord-298503-l60cdllh 352 158 macrophages macrophage NNS cord-298503-l60cdllh 353 1 The the DT cord-298503-l60cdllh 353 2 ras ras NN cord-298503-l60cdllh 353 3 - - HYPH cord-298503-l60cdllh 353 4 related relate VBN cord-298503-l60cdllh 353 5 mouse mouse NN cord-298503-l60cdllh 353 6 ypt1 ypt1 NN cord-298503-l60cdllh 353 7 protein protein NN cord-298503-l60cdllh 353 8 can can MD cord-298503-l60cdllh 353 9 functionally functionally RB cord-298503-l60cdllh 353 10 replace replace VB cord-298503-l60cdllh 353 11 the the DT cord-298503-l60cdllh 353 12 YPT1 YPT1 NNP cord-298503-l60cdllh 353 13 gene gene NN cord-298503-l60cdllh 353 14 product product NN cord-298503-l60cdllh 353 15 in in IN cord-298503-l60cdllh 353 16 yeast yeast NN cord-298503-l60cdllh 353 17 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 353 18 and and CC cord-298503-l60cdllh 353 19 traffic traffic NN cord-298503-l60cdllh 353 20 in in IN cord-298503-l60cdllh 353 21 the the DT cord-298503-l60cdllh 353 22 secretory secretory JJ cord-298503-l60cdllh 353 23 pathway pathway NN cord-298503-l60cdllh 353 24 Localization Localization NNP cord-298503-l60cdllh 353 25 , , , cord-298503-l60cdllh 353 26 dynamics dynamic NNS cord-298503-l60cdllh 353 27 , , , cord-298503-l60cdllh 353 28 and and CC cord-298503-l60cdllh 353 29 protein protein NN cord-298503-l60cdllh 353 30 interactions interaction NNS cord-298503-l60cdllh 353 31 reveal reveal VBP cord-298503-l60cdllh 353 32 distinct distinct JJ cord-298503-l60cdllh 353 33 roles role NNS cord-298503-l60cdllh 353 34 for for IN cord-298503-l60cdllh 353 35 ER ER NNP cord-298503-l60cdllh 353 36 and and CC cord-298503-l60cdllh 353 37 Golgi Golgi NNP cord-298503-l60cdllh 353 38 SNAREs SNAREs NNP cord-298503-l60cdllh 353 39 Dissecting dissect VBG cord-298503-l60cdllh 353 40 the the DT cord-298503-l60cdllh 353 41 role role NN cord-298503-l60cdllh 353 42 of of IN cord-298503-l60cdllh 353 43 the the DT cord-298503-l60cdllh 353 44 Golgi Golgi NNP cord-298503-l60cdllh 353 45 complex complex NN cord-298503-l60cdllh 353 46 and and CC cord-298503-l60cdllh 353 47 lipid lipid NN cord-298503-l60cdllh 353 48 rafts raft NNS cord-298503-l60cdllh 353 49 in in IN cord-298503-l60cdllh 353 50 biosynthetic biosynthetic JJ cord-298503-l60cdllh 353 51 transport transport NN cord-298503-l60cdllh 353 52 of of IN cord-298503-l60cdllh 353 53 cholesterol cholesterol NN cord-298503-l60cdllh 353 54 to to IN cord-298503-l60cdllh 353 55 the the DT cord-298503-l60cdllh 353 56 cell cell NN cord-298503-l60cdllh 353 57 surface surface NN cord-298503-l60cdllh 353 58 Disease Disease NNP cord-298503-l60cdllh 353 59 - - HYPH cord-298503-l60cdllh 353 60 causing cause VBG cord-298503-l60cdllh 353 61 V(2 V(2 NNP cord-298503-l60cdllh 353 62 ) ) -RRB- cord-298503-l60cdllh 354 1 vasopressin vasopressin NN cord-298503-l60cdllh 354 2 receptors receptor NNS cord-298503-l60cdllh 354 3 are be VBP cord-298503-l60cdllh 354 4 retained retain VBN cord-298503-l60cdllh 354 5 in in IN cord-298503-l60cdllh 354 6 different different JJ cord-298503-l60cdllh 354 7 compartments compartment NNS cord-298503-l60cdllh 354 8 of of IN cord-298503-l60cdllh 354 9 the the DT cord-298503-l60cdllh 354 10 early early JJ cord-298503-l60cdllh 354 11 secretory secretory JJ cord-298503-l60cdllh 354 12 pathway pathway NN cord-298503-l60cdllh 354 13 Ultrastructural Ultrastructural NNP cord-298503-l60cdllh 354 14 characterization characterization NN cord-298503-l60cdllh 354 15 of of IN cord-298503-l60cdllh 354 16 endoplasmic endoplasmic NN cord-298503-l60cdllh 354 17 reticulum reticulum NN cord-298503-l60cdllh 354 18 - - : cord-298503-l60cdllh 354 19 Golgi golgi NN cord-298503-l60cdllh 354 20 transport transport NN cord-298503-l60cdllh 354 21 containers container NNS cord-298503-l60cdllh 354 22 ( ( -LRB- cord-298503-l60cdllh 354 23 EGTC EGTC NNP cord-298503-l60cdllh 354 24 ) ) -RRB- cord-298503-l60cdllh 355 1 SEC21 SEC21 NNP cord-298503-l60cdllh 355 2 is be VBZ cord-298503-l60cdllh 355 3 a a DT cord-298503-l60cdllh 355 4 gene gene NN cord-298503-l60cdllh 355 5 required require VBN cord-298503-l60cdllh 355 6 for for IN cord-298503-l60cdllh 355 7 ER ER NNP cord-298503-l60cdllh 355 8 to to IN cord-298503-l60cdllh 355 9 Golgi Golgi NNP cord-298503-l60cdllh 355 10 protein protein NN cord-298503-l60cdllh 355 11 transport transport NN cord-298503-l60cdllh 355 12 that that WDT cord-298503-l60cdllh 355 13 encodes encode VBZ cord-298503-l60cdllh 355 14 a a DT cord-298503-l60cdllh 355 15 subunit subunit NN cord-298503-l60cdllh 355 16 of of IN cord-298503-l60cdllh 355 17 a a DT cord-298503-l60cdllh 355 18 yeast yeast NN cord-298503-l60cdllh 355 19 coatomer coatomer VBN cord-298503-l60cdllh 355 20 Calreticulin Calreticulin NNP cord-298503-l60cdllh 355 21 - - HYPH cord-298503-l60cdllh 355 22 dependent dependent JJ cord-298503-l60cdllh 355 23 recycling recycling NN cord-298503-l60cdllh 355 24 in in IN cord-298503-l60cdllh 355 25 the the DT cord-298503-l60cdllh 355 26 early early JJ cord-298503-l60cdllh 355 27 secretory secretory JJ cord-298503-l60cdllh 355 28 pathway pathway NN cord-298503-l60cdllh 355 29 mediates mediate VBZ cord-298503-l60cdllh 355 30 optimal optimal JJ cord-298503-l60cdllh 355 31 peptide peptide NN cord-298503-l60cdllh 355 32 loading loading NN cord-298503-l60cdllh 355 33 of of IN cord-298503-l60cdllh 355 34 MHC MHC NNP cord-298503-l60cdllh 355 35 class class NN cord-298503-l60cdllh 356 1 I -PRON- PRP cord-298503-l60cdllh 356 2 molecules molecule VBZ cord-298503-l60cdllh 356 3 Viral viral JJ cord-298503-l60cdllh 356 4 reorganization reorganization NN cord-298503-l60cdllh 356 5 of of IN cord-298503-l60cdllh 356 6 the the DT cord-298503-l60cdllh 356 7 secretory secretory JJ cord-298503-l60cdllh 356 8 pathway pathway NN cord-298503-l60cdllh 356 9 generates generate VBZ cord-298503-l60cdllh 356 10 distinct distinct JJ cord-298503-l60cdllh 356 11 organelles organelle NNS cord-298503-l60cdllh 356 12 for for IN cord-298503-l60cdllh 356 13 RNA RNA NNP cord-298503-l60cdllh 356 14 replication replication NN cord-298503-l60cdllh 357 1 A a DT cord-298503-l60cdllh 357 2 recycling recycling NN cord-298503-l60cdllh 357 3 pathway pathway NN cord-298503-l60cdllh 357 4 between between IN cord-298503-l60cdllh 357 5 the the DT cord-298503-l60cdllh 357 6 endoplasmic endoplasmic NN cord-298503-l60cdllh 357 7 reticulum reticulum NN cord-298503-l60cdllh 357 8 and and CC cord-298503-l60cdllh 357 9 the the DT cord-298503-l60cdllh 357 10 Golgi Golgi NNP cord-298503-l60cdllh 357 11 apparatus apparatus NN cord-298503-l60cdllh 357 12 for for IN cord-298503-l60cdllh 357 13 retention retention NN cord-298503-l60cdllh 357 14 of of IN cord-298503-l60cdllh 357 15 unassembled unassembled JJ cord-298503-l60cdllh 357 16 MHC MHC NNP cord-298503-l60cdllh 357 17 class class NN cord-298503-l60cdllh 358 1 I -PRON- PRP cord-298503-l60cdllh 358 2 molecules molecule NNS cord-298503-l60cdllh 359 1 Antibacterial antibacterial JJ cord-298503-l60cdllh 359 2 autophagy autophagy NN cord-298503-l60cdllh 359 3 occurs occur VBZ cord-298503-l60cdllh 359 4 at at IN cord-298503-l60cdllh 359 5 PI(3)P pi(3)p NN cord-298503-l60cdllh 359 6 - - HYPH cord-298503-l60cdllh 359 7 enriched enrich VBN cord-298503-l60cdllh 359 8 domains domain NNS cord-298503-l60cdllh 359 9 of of IN cord-298503-l60cdllh 359 10 the the DT cord-298503-l60cdllh 359 11 endoplasmic endoplasmic NN cord-298503-l60cdllh 359 12 reticulum reticulum NN cord-298503-l60cdllh 359 13 and and CC cord-298503-l60cdllh 359 14 requires require VBZ cord-298503-l60cdllh 359 15 Rab1 Rab1 NNP cord-298503-l60cdllh 359 16 GTPase GTPase NNP cord-298503-l60cdllh 360 1 The the DT cord-298503-l60cdllh 360 2 Legionella Legionella NNP cord-298503-l60cdllh 360 3 pneumophila pneumophila NN cord-298503-l60cdllh 360 4 replication replication NN cord-298503-l60cdllh 360 5 vacuole vacuole NN cord-298503-l60cdllh 360 6 : : : cord-298503-l60cdllh 361 1 Making make VBG cord-298503-l60cdllh 361 2 a a DT cord-298503-l60cdllh 361 3 cosy cosy JJ cord-298503-l60cdllh 361 4 niche niche NN cord-298503-l60cdllh 361 5 inside inside IN cord-298503-l60cdllh 361 6 host host NN cord-298503-l60cdllh 361 7 cells cell NNS cord-298503-l60cdllh 362 1 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 362 2 is be VBZ cord-298503-l60cdllh 362 3 a a DT cord-298503-l60cdllh 362 4 functional functional JJ cord-298503-l60cdllh 362 5 mannose mannose NN cord-298503-l60cdllh 362 6 - - HYPH cord-298503-l60cdllh 362 7 selective selective JJ cord-298503-l60cdllh 362 8 and and CC cord-298503-l60cdllh 362 9 calcium calcium NN cord-298503-l60cdllh 362 10 - - HYPH cord-298503-l60cdllh 362 11 dependent dependent JJ cord-298503-l60cdllh 362 12 human human JJ cord-298503-l60cdllh 362 13 homologue homologue NN cord-298503-l60cdllh 362 14 of of IN cord-298503-l60cdllh 362 15 leguminous leguminous JJ cord-298503-l60cdllh 362 16 lectins lectin NNS cord-298503-l60cdllh 362 17 Identification Identification NNP cord-298503-l60cdllh 362 18 of of IN cord-298503-l60cdllh 362 19 a a DT cord-298503-l60cdllh 362 20 consensus consensus NN cord-298503-l60cdllh 362 21 motif motif NN cord-298503-l60cdllh 362 22 for for IN cord-298503-l60cdllh 362 23 retention retention NN cord-298503-l60cdllh 362 24 of of IN cord-298503-l60cdllh 362 25 transmembrane transmembrane JJ cord-298503-l60cdllh 362 26 proteins protein NNS cord-298503-l60cdllh 362 27 in in IN cord-298503-l60cdllh 362 28 the the DT cord-298503-l60cdllh 362 29 endoplasmic endoplasmic NN cord-298503-l60cdllh 362 30 reticulum reticulum NN cord-298503-l60cdllh 362 31 Retrieval Retrieval NNP cord-298503-l60cdllh 362 32 of of IN cord-298503-l60cdllh 362 33 transmembrane transmembrane NN cord-298503-l60cdllh 362 34 proteins protein NNS cord-298503-l60cdllh 362 35 to to IN cord-298503-l60cdllh 362 36 the the DT cord-298503-l60cdllh 362 37 endoplasmic endoplasmic NN cord-298503-l60cdllh 362 38 reticulum reticulum NN cord-298503-l60cdllh 362 39 Intracellular Intracellular NNP cord-298503-l60cdllh 362 40 transport transport NN cord-298503-l60cdllh 362 41 of of IN cord-298503-l60cdllh 362 42 secretory secretory JJ cord-298503-l60cdllh 362 43 proteins protein NNS cord-298503-l60cdllh 362 44 in in IN cord-298503-l60cdllh 362 45 the the DT cord-298503-l60cdllh 362 46 pancreatic pancreatic JJ cord-298503-l60cdllh 362 47 exocrine exocrine JJ cord-298503-l60cdllh 362 48 cell cell NN cord-298503-l60cdllh 362 49 . . . cord-298503-l60cdllh 363 1 I. I. NNP cord-298503-l60cdllh 363 2 Role role NN cord-298503-l60cdllh 363 3 of of IN cord-298503-l60cdllh 363 4 the the DT cord-298503-l60cdllh 363 5 peripheral peripheral JJ cord-298503-l60cdllh 363 6 elements element NNS cord-298503-l60cdllh 363 7 of of IN cord-298503-l60cdllh 363 8 the the DT cord-298503-l60cdllh 363 9 Golgi Golgi NNP cord-298503-l60cdllh 363 10 complex complex NN cord-298503-l60cdllh 363 11 Immunocytochemical Immunocytochemical NNP cord-298503-l60cdllh 363 12 analysis analysis NN cord-298503-l60cdllh 363 13 of of IN cord-298503-l60cdllh 363 14 Uukuniemi Uukuniemi NNP cord-298503-l60cdllh 363 15 virus virus NN cord-298503-l60cdllh 363 16 budding bud VBG cord-298503-l60cdllh 363 17 compartments compartment NNS cord-298503-l60cdllh 363 18 : : : cord-298503-l60cdllh 363 19 Role role NN cord-298503-l60cdllh 363 20 of of IN cord-298503-l60cdllh 363 21 the the DT cord-298503-l60cdllh 363 22 intermediate intermediate JJ cord-298503-l60cdllh 363 23 compartment compartment NN cord-298503-l60cdllh 363 24 and and CC cord-298503-l60cdllh 363 25 the the DT cord-298503-l60cdllh 363 26 Golgi Golgi NNP cord-298503-l60cdllh 363 27 stack stack NN cord-298503-l60cdllh 363 28 in in RP cord-298503-l60cdllh 364 1 virus virus NN cord-298503-l60cdllh 364 2 maturation maturation NN cord-298503-l60cdllh 365 1 Irradiation irradiation NN cord-298503-l60cdllh 365 2 - - HYPH cord-298503-l60cdllh 365 3 induced induce VBN cord-298503-l60cdllh 365 4 protein protein NN cord-298503-l60cdllh 365 5 inactivation inactivation NN cord-298503-l60cdllh 365 6 reveals reveal VBZ cord-298503-l60cdllh 365 7 Golgi Golgi NNP cord-298503-l60cdllh 365 8 enzyme enzyme NN cord-298503-l60cdllh 365 9 cycling cycling NN cord-298503-l60cdllh 365 10 to to IN cord-298503-l60cdllh 365 11 cell cell NN cord-298503-l60cdllh 365 12 periphery periphery NN cord-298503-l60cdllh 365 13 Initiation Initiation NNP cord-298503-l60cdllh 365 14 of of IN cord-298503-l60cdllh 365 15 the the DT cord-298503-l60cdllh 365 16 decorin decorin NNP cord-298503-l60cdllh 365 17 glycosaminoglycan glycosaminoglycan NNP cord-298503-l60cdllh 365 18 chain chain NN cord-298503-l60cdllh 365 19 in in IN cord-298503-l60cdllh 365 20 the the DT cord-298503-l60cdllh 365 21 endoplasmic endoplasmic NN cord-298503-l60cdllh 365 22 reticulum reticulum NN cord-298503-l60cdllh 365 23 - - : cord-298503-l60cdllh 365 24 Golgi Golgi NNP cord-298503-l60cdllh 365 25 intermediate intermediate JJ cord-298503-l60cdllh 365 26 compartment compartment NN cord-298503-l60cdllh 365 27 Ypt1p Ypt1p NNP cord-298503-l60cdllh 365 28 is be VBZ cord-298503-l60cdllh 365 29 essential essential JJ cord-298503-l60cdllh 365 30 for for IN cord-298503-l60cdllh 365 31 retrograde retrograde JJ cord-298503-l60cdllh 365 32 Golgi Golgi NNP cord-298503-l60cdllh 365 33 - - HYPH cord-298503-l60cdllh 365 34 ER er NN cord-298503-l60cdllh 365 35 transport transport NN cord-298503-l60cdllh 365 36 and and CC cord-298503-l60cdllh 365 37 for for IN cord-298503-l60cdllh 365 38 Golgi Golgi NNP cord-298503-l60cdllh 365 39 maintenance maintenance NN cord-298503-l60cdllh 365 40 in in IN cord-298503-l60cdllh 365 41 S. S. NNP cord-298503-l60cdllh 365 42 cerevisiae cerevisiae NNS cord-298503-l60cdllh 365 43 Yip1A Yip1A NNS cord-298503-l60cdllh 365 44 regulates regulate VBZ cord-298503-l60cdllh 365 45 the the DT cord-298503-l60cdllh 365 46 COPIindependent copiindependent NN cord-298503-l60cdllh 365 47 retrograde retrograde JJ cord-298503-l60cdllh 365 48 transport transport NN cord-298503-l60cdllh 365 49 from from IN cord-298503-l60cdllh 365 50 the the DT cord-298503-l60cdllh 365 51 Golgi Golgi NNP cord-298503-l60cdllh 365 52 complex complex NN cord-298503-l60cdllh 365 53 to to IN cord-298503-l60cdllh 365 54 the the DT cord-298503-l60cdllh 365 55 ER er NN cord-298503-l60cdllh 366 1 The the DT cord-298503-l60cdllh 366 2 recycling recycling NN cord-298503-l60cdllh 366 3 of of IN cord-298503-l60cdllh 366 4 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 366 5 in in IN cord-298503-l60cdllh 366 6 the the DT cord-298503-l60cdllh 366 7 early early JJ cord-298503-l60cdllh 366 8 secretory secretory JJ cord-298503-l60cdllh 366 9 pathway pathway NN cord-298503-l60cdllh 366 10 . . . cord-298503-l60cdllh 367 1 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 367 2 carries carry VBZ cord-298503-l60cdllh 367 3 a a DT cord-298503-l60cdllh 367 4 cytosolic cytosolic JJ cord-298503-l60cdllh 367 5 endoplasmic endoplasmic NN cord-298503-l60cdllh 367 6 reticulum reticulum NN cord-298503-l60cdllh 367 7 - - HYPH cord-298503-l60cdllh 367 8 exit exit NN cord-298503-l60cdllh 367 9 determinant determinant NN cord-298503-l60cdllh 367 10 interacting interact VBG cord-298503-l60cdllh 367 11 with with IN cord-298503-l60cdllh 367 12 COPII COPII NNP cord-298503-l60cdllh 367 13 GBF1 GBF1 NNP cord-298503-l60cdllh 367 14 , , , cord-298503-l60cdllh 367 15 a a DT cord-298503-l60cdllh 367 16 guanine guanine NN cord-298503-l60cdllh 367 17 nucleotide nucleotide JJ cord-298503-l60cdllh 367 18 exchange exchange NN cord-298503-l60cdllh 367 19 factor factor NN cord-298503-l60cdllh 367 20 for for IN cord-298503-l60cdllh 367 21 ADP adp NN cord-298503-l60cdllh 367 22 - - HYPH cord-298503-l60cdllh 367 23 ribosylation ribosylation NN cord-298503-l60cdllh 367 24 factors factor NNS cord-298503-l60cdllh 367 25 , , , cord-298503-l60cdllh 367 26 is be VBZ cord-298503-l60cdllh 367 27 localized localize VBN cord-298503-l60cdllh 367 28 to to IN cord-298503-l60cdllh 367 29 the the DT cord-298503-l60cdllh 367 30 cis cis NNP cord-298503-l60cdllh 367 31 - - HYPH cord-298503-l60cdllh 367 32 Golgi Golgi NNP cord-298503-l60cdllh 367 33 and and CC cord-298503-l60cdllh 367 34 involved involve VBN cord-298503-l60cdllh 367 35 in in IN cord-298503-l60cdllh 367 36 membrane membrane NNP cord-298503-l60cdllh 367 37 association association NNP cord-298503-l60cdllh 367 38 of of IN cord-298503-l60cdllh 367 39 the the DT cord-298503-l60cdllh 367 40 COPI COPI NNP cord-298503-l60cdllh 367 41 coat coat NN cord-298503-l60cdllh 368 1 The the DT cord-298503-l60cdllh 368 2 intracellular intracellular JJ cord-298503-l60cdllh 368 3 cargo cargo NN cord-298503-l60cdllh 368 4 receptor receptor NN cord-298503-l60cdllh 368 5 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 368 6 is be VBZ cord-298503-l60cdllh 368 7 required require VBN cord-298503-l60cdllh 368 8 for for IN cord-298503-l60cdllh 368 9 the the DT cord-298503-l60cdllh 368 10 production production NN cord-298503-l60cdllh 368 11 of of IN cord-298503-l60cdllh 368 12 infectious infectious JJ cord-298503-l60cdllh 368 13 arenavirus arenavirus NN cord-298503-l60cdllh 368 14 , , , cord-298503-l60cdllh 368 15 coronavirus coronavirus NN cord-298503-l60cdllh 368 16 , , , cord-298503-l60cdllh 368 17 and and CC cord-298503-l60cdllh 368 18 filovirus filovirus NN cord-298503-l60cdllh 368 19 particles particle NNS cord-298503-l60cdllh 368 20 Location Location NNP cord-298503-l60cdllh 368 21 of of IN cord-298503-l60cdllh 368 22 MHC MHC NNP cord-298503-l60cdllh 368 23 - - HYPH cord-298503-l60cdllh 368 24 encoded encode VBN cord-298503-l60cdllh 368 25 transporters transporter NNS cord-298503-l60cdllh 368 26 in in IN cord-298503-l60cdllh 368 27 the the DT cord-298503-l60cdllh 368 28 endoplasmic endoplasmic NN cord-298503-l60cdllh 368 29 reticulum reticulum NN cord-298503-l60cdllh 368 30 and and CC cord-298503-l60cdllh 368 31 cis cis NNP cord-298503-l60cdllh 368 32 - - HYPH cord-298503-l60cdllh 368 33 Golgi Golgi NNP cord-298503-l60cdllh 368 34 Coronavirus Coronavirus NNP cord-298503-l60cdllh 368 35 M M NNP cord-298503-l60cdllh 368 36 proteins protein NNS cord-298503-l60cdllh 368 37 accumulate accumulate VBP cord-298503-l60cdllh 368 38 in in IN cord-298503-l60cdllh 368 39 the the DT cord-298503-l60cdllh 368 40 Golgi Golgi NNP cord-298503-l60cdllh 368 41 complex complex NN cord-298503-l60cdllh 368 42 beyond beyond IN cord-298503-l60cdllh 368 43 the the DT cord-298503-l60cdllh 368 44 site site NN cord-298503-l60cdllh 368 45 of of IN cord-298503-l60cdllh 368 46 virion virion NN cord-298503-l60cdllh 368 47 budding bud VBG cord-298503-l60cdllh 368 48 The the DT cord-298503-l60cdllh 368 49 recycling recycling NN cord-298503-l60cdllh 368 50 pathway pathway NN cord-298503-l60cdllh 368 51 of of IN cord-298503-l60cdllh 368 52 protein protein NNP cord-298503-l60cdllh 368 53 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 368 54 and and CC cord-298503-l60cdllh 368 55 dynamics dynamic NNS cord-298503-l60cdllh 368 56 of of IN cord-298503-l60cdllh 368 57 the the DT cord-298503-l60cdllh 368 58 ER ER NNP cord-298503-l60cdllh 368 59 - - HYPH cord-298503-l60cdllh 368 60 Golgi Golgi NNP cord-298503-l60cdllh 368 61 intermediate intermediate JJ cord-298503-l60cdllh 368 62 compartment compartment NN cord-298503-l60cdllh 368 63 Characterization characterization NN cord-298503-l60cdllh 368 64 of of IN cord-298503-l60cdllh 368 65 the the DT cord-298503-l60cdllh 368 66 budding bud VBG cord-298503-l60cdllh 368 67 compartment compartment NN cord-298503-l60cdllh 368 68 of of IN cord-298503-l60cdllh 368 69 mouse mouse NNP cord-298503-l60cdllh 368 70 hepatitis hepatitis NNP cord-298503-l60cdllh 368 71 virus virus NN cord-298503-l60cdllh 368 72 : : : cord-298503-l60cdllh 369 1 Evidence evidence NN cord-298503-l60cdllh 369 2 that that DT cord-298503-l60cdllh 369 3 transport transport NN cord-298503-l60cdllh 369 4 from from IN cord-298503-l60cdllh 369 5 the the DT cord-298503-l60cdllh 369 6 RER RER NNP cord-298503-l60cdllh 369 7 to to IN cord-298503-l60cdllh 369 8 the the DT cord-298503-l60cdllh 369 9 Golgi Golgi NNP cord-298503-l60cdllh 369 10 complex complex NN cord-298503-l60cdllh 369 11 requires require VBZ cord-298503-l60cdllh 369 12 only only RB cord-298503-l60cdllh 369 13 one one CD cord-298503-l60cdllh 369 14 vesicular vesicular JJ cord-298503-l60cdllh 369 15 transport transport NN cord-298503-l60cdllh 369 16 step step NN cord-298503-l60cdllh 370 1 The the DT cord-298503-l60cdllh 370 2 organization organization NN cord-298503-l60cdllh 370 3 of of IN cord-298503-l60cdllh 370 4 the the DT cord-298503-l60cdllh 370 5 endoplasmic endoplasmic NN cord-298503-l60cdllh 370 6 reticulum reticulum NN cord-298503-l60cdllh 370 7 and and CC cord-298503-l60cdllh 370 8 the the DT cord-298503-l60cdllh 370 9 intermediate intermediate JJ cord-298503-l60cdllh 370 10 compartment compartment NN cord-298503-l60cdllh 370 11 in in IN cord-298503-l60cdllh 370 12 cultured cultured JJ cord-298503-l60cdllh 370 13 rat rat NN cord-298503-l60cdllh 370 14 hippocampal hippocampal JJ cord-298503-l60cdllh 370 15 neurons neuron NNS cord-298503-l60cdllh 370 16 Low low JJ cord-298503-l60cdllh 370 17 temperature temperature NN cord-298503-l60cdllh 370 18 - - HYPH cord-298503-l60cdllh 370 19 induced induce VBN cord-298503-l60cdllh 370 20 transport transport NN cord-298503-l60cdllh 370 21 blocks block NNS cord-298503-l60cdllh 370 22 as as IN cord-298503-l60cdllh 370 23 tools tool NNS cord-298503-l60cdllh 370 24 to to TO cord-298503-l60cdllh 370 25 manipulate manipulate VB cord-298503-l60cdllh 370 26 membrane membrane NN cord-298503-l60cdllh 370 27 traffic traffic NN cord-298503-l60cdllh 370 28 Golgi Golgi NNP cord-298503-l60cdllh 370 29 structure structure NN cord-298503-l60cdllh 370 30 in in IN cord-298503-l60cdllh 370 31 three three CD cord-298503-l60cdllh 370 32 dimensions dimension NNS cord-298503-l60cdllh 370 33 : : : cord-298503-l60cdllh 371 1 Functional functional JJ cord-298503-l60cdllh 371 2 insights insight NNS cord-298503-l60cdllh 371 3 from from IN cord-298503-l60cdllh 371 4 the the DT cord-298503-l60cdllh 371 5 normal normal JJ cord-298503-l60cdllh 371 6 rat rat NN cord-298503-l60cdllh 371 7 kidney kidney NN cord-298503-l60cdllh 371 8 cell cell NN cord-298503-l60cdllh 371 9 Characterization characterization NN cord-298503-l60cdllh 371 10 of of IN cord-298503-l60cdllh 371 11 a a DT cord-298503-l60cdllh 371 12 58 58 CD cord-298503-l60cdllh 371 13 kDa kDa NNP cord-298503-l60cdllh 371 14 cis cis NNP cord-298503-l60cdllh 371 15 - - HYPH cord-298503-l60cdllh 371 16 Golgi Golgi NNP cord-298503-l60cdllh 371 17 protein protein NN cord-298503-l60cdllh 371 18 in in IN cord-298503-l60cdllh 371 19 pancreatic pancreatic JJ cord-298503-l60cdllh 371 20 exocrine exocrine NN cord-298503-l60cdllh 371 21 cells cell NNS cord-298503-l60cdllh 371 22 Molecular molecular JJ cord-298503-l60cdllh 371 23 cloning cloning NN cord-298503-l60cdllh 371 24 and and CC cord-298503-l60cdllh 371 25 expression expression NN cord-298503-l60cdllh 371 26 of of IN cord-298503-l60cdllh 371 27 a a DT cord-298503-l60cdllh 371 28 58-kDa 58-kda CD cord-298503-l60cdllh 371 29 cis cis NNP cord-298503-l60cdllh 371 30 - - HYPH cord-298503-l60cdllh 371 31 Golgi Golgi NNP cord-298503-l60cdllh 371 32 and and CC cord-298503-l60cdllh 371 33 intermediate intermediate JJ cord-298503-l60cdllh 371 34 compartment compartment NN cord-298503-l60cdllh 371 35 protein protein NN cord-298503-l60cdllh 371 36 Roles Roles NNP cord-298503-l60cdllh 371 37 for for IN cord-298503-l60cdllh 371 38 alpha(2)p24 alpha(2)p24 NNP cord-298503-l60cdllh 371 39 and and CC cord-298503-l60cdllh 371 40 COPI COPI NNP cord-298503-l60cdllh 371 41 in in IN cord-298503-l60cdllh 371 42 endoplasmic endoplasmic NN cord-298503-l60cdllh 371 43 reticulum reticulum NN cord-298503-l60cdllh 371 44 cargo cargo NN cord-298503-l60cdllh 371 45 exit exit NN cord-298503-l60cdllh 371 46 site site NN cord-298503-l60cdllh 371 47 formation formation NN cord-298503-l60cdllh 371 48 Biosynthesis Biosynthesis NNP cord-298503-l60cdllh 371 49 of of IN cord-298503-l60cdllh 371 50 the the DT cord-298503-l60cdllh 371 51 mannose-6-phosphate mannose-6-phosphate NNP cord-298503-l60cdllh 371 52 recognition recognition NN cord-298503-l60cdllh 371 53 marker marker NN cord-298503-l60cdllh 371 54 in in IN cord-298503-l60cdllh 371 55 transport transport NN cord-298503-l60cdllh 371 56 - - HYPH cord-298503-l60cdllh 371 57 impaired impair VBN cord-298503-l60cdllh 371 58 mouse mouse NN cord-298503-l60cdllh 371 59 lymphoma lymphoma NN cord-298503-l60cdllh 371 60 cells cell NNS cord-298503-l60cdllh 371 61 . . . cord-298503-l60cdllh 372 1 Demonstration demonstration NN cord-298503-l60cdllh 372 2 of of IN cord-298503-l60cdllh 372 3 a a DT cord-298503-l60cdllh 372 4 two two CD cord-298503-l60cdllh 372 5 - - HYPH cord-298503-l60cdllh 372 6 step step NN cord-298503-l60cdllh 372 7 phosphorylation phosphorylation NN cord-298503-l60cdllh 372 8 Bi bi JJ cord-298503-l60cdllh 372 9 - - HYPH cord-298503-l60cdllh 372 10 directional directional JJ cord-298503-l60cdllh 372 11 protein protein NN cord-298503-l60cdllh 372 12 transport transport NN cord-298503-l60cdllh 372 13 between between IN cord-298503-l60cdllh 372 14 the the DT cord-298503-l60cdllh 372 15 ER ER NNP cord-298503-l60cdllh 372 16 and and CC cord-298503-l60cdllh 372 17 Golgi Golgi NNP cord-298503-l60cdllh 372 18 A a DT cord-298503-l60cdllh 372 19 human human JJ cord-298503-l60cdllh 372 20 homologue homologue NN cord-298503-l60cdllh 372 21 of of IN cord-298503-l60cdllh 372 22 the the DT cord-298503-l60cdllh 372 23 yeast yeast NN cord-298503-l60cdllh 372 24 HDEL HDEL NNP cord-298503-l60cdllh 372 25 receptor receptor NN cord-298503-l60cdllh 372 26 ER ER NNP cord-298503-l60cdllh 372 27 / / SYM cord-298503-l60cdllh 372 28 Golgi Golgi NNP cord-298503-l60cdllh 372 29 intermediates intermediate NNS cord-298503-l60cdllh 372 30 acquire acquire VBP cord-298503-l60cdllh 372 31 Golgi Golgi NNP cord-298503-l60cdllh 372 32 enzymes enzyme NNS cord-298503-l60cdllh 372 33 by by IN cord-298503-l60cdllh 372 34 brefeldin brefeldin NNP cord-298503-l60cdllh 372 35 A A NNP cord-298503-l60cdllh 372 36 - - HYPH cord-298503-l60cdllh 372 37 sensitive sensitive JJ cord-298503-l60cdllh 372 38 retrograde retrograde JJ cord-298503-l60cdllh 372 39 transport transport NN cord-298503-l60cdllh 372 40 in in IN cord-298503-l60cdllh 372 41 vitro vitro FW cord-298503-l60cdllh 372 42 Regulation regulation NN cord-298503-l60cdllh 372 43 of of IN cord-298503-l60cdllh 372 44 selective selective JJ cord-298503-l60cdllh 372 45 autophagy autophagy NN cord-298503-l60cdllh 372 46 onset onset NN cord-298503-l60cdllh 372 47 by by IN cord-298503-l60cdllh 372 48 a a DT cord-298503-l60cdllh 372 49 Ypt Ypt NNP cord-298503-l60cdllh 372 50 / / SYM cord-298503-l60cdllh 372 51 Rab Rab NNP cord-298503-l60cdllh 372 52 GTPase GTPase NNP cord-298503-l60cdllh 372 53 module module NN cord-298503-l60cdllh 372 54 Kinesin Kinesin NNP cord-298503-l60cdllh 372 55 is be VBZ cord-298503-l60cdllh 372 56 the the DT cord-298503-l60cdllh 372 57 motor motor NN cord-298503-l60cdllh 372 58 for for IN cord-298503-l60cdllh 372 59 microtubule microtubule NN cord-298503-l60cdllh 372 60 - - HYPH cord-298503-l60cdllh 372 61 mediated mediate VBN cord-298503-l60cdllh 372 62 Golgi golgi NN cord-298503-l60cdllh 372 63 - - HYPH cord-298503-l60cdllh 372 64 to to IN cord-298503-l60cdllh 372 65 - - HYPH cord-298503-l60cdllh 372 66 ER er NN cord-298503-l60cdllh 372 67 membrane membrane NN cord-298503-l60cdllh 372 68 traffic traffic NN cord-298503-l60cdllh 372 69 Microtubuledependent Microtubuledependent NNP cord-298503-l60cdllh 372 70 retrograde retrograde JJ cord-298503-l60cdllh 372 71 transport transport NN cord-298503-l60cdllh 372 72 of of IN cord-298503-l60cdllh 372 73 proteins protein NNS cord-298503-l60cdllh 372 74 into into IN cord-298503-l60cdllh 372 75 the the DT cord-298503-l60cdllh 372 76 ER ER NNP cord-298503-l60cdllh 372 77 in in IN cord-298503-l60cdllh 372 78 the the DT cord-298503-l60cdllh 372 79 presence presence NN cord-298503-l60cdllh 372 80 of of IN cord-298503-l60cdllh 372 81 brefeldin brefeldin NNP cord-298503-l60cdllh 373 1 A a DT cord-298503-l60cdllh 373 2 suggests suggest VBZ cord-298503-l60cdllh 373 3 an an DT cord-298503-l60cdllh 373 4 ER ER NNP cord-298503-l60cdllh 373 5 recycling recycling NN cord-298503-l60cdllh 373 6 pathway pathway NN cord-298503-l60cdllh 373 7 Immunocytochemical Immunocytochemical NNP cord-298503-l60cdllh 373 8 analysis analysis NN cord-298503-l60cdllh 373 9 of of IN cord-298503-l60cdllh 373 10 the the DT cord-298503-l60cdllh 373 11 transfer transfer NN cord-298503-l60cdllh 373 12 of of IN cord-298503-l60cdllh 373 13 vesicular vesicular JJ cord-298503-l60cdllh 373 14 stomatitis stomatitis NN cord-298503-l60cdllh 373 15 virus virus NN cord-298503-l60cdllh 373 16 G g NN cord-298503-l60cdllh 373 17 glycoprotein glycoprotein NN cord-298503-l60cdllh 373 18 from from IN cord-298503-l60cdllh 373 19 the the DT cord-298503-l60cdllh 373 20 intermediate intermediate JJ cord-298503-l60cdllh 373 21 compartment compartment NN cord-298503-l60cdllh 373 22 to to IN cord-298503-l60cdllh 373 23 the the DT cord-298503-l60cdllh 373 24 Golgi Golgi NNP cord-298503-l60cdllh 373 25 complex complex JJ cord-298503-l60cdllh 373 26 Regulation regulation NN cord-298503-l60cdllh 373 27 of of IN cord-298503-l60cdllh 373 28 protein protein NN cord-298503-l60cdllh 373 29 transport transport NN cord-298503-l60cdllh 373 30 from from IN cord-298503-l60cdllh 373 31 the the DT cord-298503-l60cdllh 373 32 Golgi Golgi NNP cord-298503-l60cdllh 373 33 complex complex NN cord-298503-l60cdllh 373 34 to to IN cord-298503-l60cdllh 373 35 the the DT cord-298503-l60cdllh 373 36 endoplasmic endoplasmic NN cord-298503-l60cdllh 373 37 reticulum reticulum NN cord-298503-l60cdllh 373 38 by by IN cord-298503-l60cdllh 373 39 CDC42 CDC42 NNP cord-298503-l60cdllh 373 40 and and CC cord-298503-l60cdllh 373 41 N N NNP cord-298503-l60cdllh 373 42 - - HYPH cord-298503-l60cdllh 373 43 WASP WASP NNP cord-298503-l60cdllh 373 44 Trs85 Trs85 NNP cord-298503-l60cdllh 373 45 directs direct VBZ cord-298503-l60cdllh 373 46 a a DT cord-298503-l60cdllh 373 47 Ypt1 ypt1 NN cord-298503-l60cdllh 373 48 GEF gef NN cord-298503-l60cdllh 373 49 , , , cord-298503-l60cdllh 373 50 TRAPPIII TRAPPIII NNP cord-298503-l60cdllh 373 51 , , , cord-298503-l60cdllh 373 52 to to IN cord-298503-l60cdllh 373 53 the the DT cord-298503-l60cdllh 373 54 phagophore phagophore NN cord-298503-l60cdllh 373 55 to to TO cord-298503-l60cdllh 373 56 promote promote VB cord-298503-l60cdllh 373 57 autophagy autophagy NN cord-298503-l60cdllh 373 58 KDEL KDEL NNP cord-298503-l60cdllh 373 59 - - HYPH cord-298503-l60cdllh 373 60 cargo cargo NN cord-298503-l60cdllh 373 61 regulates regulate VBZ cord-298503-l60cdllh 373 62 interactions interaction NNS cord-298503-l60cdllh 373 63 between between IN cord-298503-l60cdllh 373 64 proteins protein NNS cord-298503-l60cdllh 373 65 involved involve VBN cord-298503-l60cdllh 373 66 in in IN cord-298503-l60cdllh 373 67 COPI COPI NNP cord-298503-l60cdllh 373 68 vesicle vesicle NN cord-298503-l60cdllh 373 69 traffic traffic NN cord-298503-l60cdllh 373 70 : : : cord-298503-l60cdllh 374 1 Measurements measurement NNS cord-298503-l60cdllh 374 2 in in IN cord-298503-l60cdllh 374 3 living living NN cord-298503-l60cdllh 374 4 cells cell NNS cord-298503-l60cdllh 374 5 using use VBG cord-298503-l60cdllh 374 6 FRET FRET NNP cord-298503-l60cdllh 374 7 Golgin Golgin NNP cord-298503-l60cdllh 374 8 tethers tether NNS cord-298503-l60cdllh 374 9 define define VBP cord-298503-l60cdllh 374 10 subpopulations subpopulation NNS cord-298503-l60cdllh 374 11 of of IN cord-298503-l60cdllh 374 12 COPI COPI NNP cord-298503-l60cdllh 374 13 vesicles vesicle NNS cord-298503-l60cdllh 374 14 Distinct distinct JJ cord-298503-l60cdllh 374 15 functions function NNS cord-298503-l60cdllh 374 16 for for IN cord-298503-l60cdllh 374 17 Arf Arf NNP cord-298503-l60cdllh 374 18 nucleotide nucleotide JJ cord-298503-l60cdllh 374 19 exchange exchange NN cord-298503-l60cdllh 374 20 factors factor NNS cord-298503-l60cdllh 374 21 at at IN cord-298503-l60cdllh 374 22 the the DT cord-298503-l60cdllh 374 23 Golgi Golgi NNP cord-298503-l60cdllh 374 24 complex complex NN cord-298503-l60cdllh 374 25 : : : cord-298503-l60cdllh 374 26 GBF1 GBF1 NNP cord-298503-l60cdllh 374 27 and and CC cord-298503-l60cdllh 374 28 BIGs BIGs NNP cord-298503-l60cdllh 374 29 are be VBP cord-298503-l60cdllh 374 30 required require VBN cord-298503-l60cdllh 374 31 for for IN cord-298503-l60cdllh 374 32 assembly assembly NN cord-298503-l60cdllh 374 33 and and CC cord-298503-l60cdllh 374 34 maintenance maintenance NN cord-298503-l60cdllh 374 35 of of IN cord-298503-l60cdllh 374 36 the the DT cord-298503-l60cdllh 374 37 Golgi Golgi NNP cord-298503-l60cdllh 374 38 stack stack NN cord-298503-l60cdllh 374 39 and and CC cord-298503-l60cdllh 374 40 TGN TGN NNP cord-298503-l60cdllh 374 41 , , , cord-298503-l60cdllh 374 42 respectively respectively RB cord-298503-l60cdllh 374 43 Division Division NNP cord-298503-l60cdllh 374 44 of of IN cord-298503-l60cdllh 374 45 the the DT cord-298503-l60cdllh 374 46 intermediate intermediate JJ cord-298503-l60cdllh 374 47 compartment compartment NN cord-298503-l60cdllh 374 48 at at IN cord-298503-l60cdllh 374 49 the the DT cord-298503-l60cdllh 374 50 onset onset NN cord-298503-l60cdllh 374 51 of of IN cord-298503-l60cdllh 374 52 mitosis mitosis NN cord-298503-l60cdllh 374 53 provides provide VBZ cord-298503-l60cdllh 374 54 a a DT cord-298503-l60cdllh 374 55 mechanism mechanism NN cord-298503-l60cdllh 374 56 for for IN cord-298503-l60cdllh 374 57 Golgi Golgi NNP cord-298503-l60cdllh 374 58 inheritance inheritance NN cord-298503-l60cdllh 375 1 The the DT cord-298503-l60cdllh 375 2 function function NN cord-298503-l60cdllh 375 3 of of IN cord-298503-l60cdllh 375 4 the the DT cord-298503-l60cdllh 375 5 intermediate intermediate JJ cord-298503-l60cdllh 375 6 compartment compartment NN cord-298503-l60cdllh 375 7 in in IN cord-298503-l60cdllh 375 8 pre pre JJ cord-298503-l60cdllh 375 9 - - JJ cord-298503-l60cdllh 375 10 Golgi golgi JJ cord-298503-l60cdllh 375 11 trafficking trafficking NN cord-298503-l60cdllh 375 12 involves involve VBZ cord-298503-l60cdllh 375 13 its -PRON- PRP$ cord-298503-l60cdllh 375 14 stable stable JJ cord-298503-l60cdllh 375 15 connection connection NN cord-298503-l60cdllh 375 16 with with IN cord-298503-l60cdllh 375 17 the the DT cord-298503-l60cdllh 375 18 centrosome centrosome NN cord-298503-l60cdllh 375 19 Take take VB cord-298503-l60cdllh 375 20 the the DT cord-298503-l60cdllh 375 21 ' ' `` cord-298503-l60cdllh 375 22 A a DT cord-298503-l60cdllh 375 23 ' ' '' cord-298503-l60cdllh 375 24 train train NN cord-298503-l60cdllh 375 25 : : : cord-298503-l60cdllh 375 26 On on IN cord-298503-l60cdllh 375 27 fast fast JJ cord-298503-l60cdllh 375 28 tracks track NNS cord-298503-l60cdllh 375 29 to to IN cord-298503-l60cdllh 375 30 the the DT cord-298503-l60cdllh 375 31 cell cell NN cord-298503-l60cdllh 375 32 surface surface NN cord-298503-l60cdllh 375 33 The the DT cord-298503-l60cdllh 375 34 GM130 GM130 NNP cord-298503-l60cdllh 375 35 and and CC cord-298503-l60cdllh 375 36 GRASP65 GRASP65 NNP cord-298503-l60cdllh 375 37 Golgi Golgi NNP cord-298503-l60cdllh 375 38 proteins protein NNS cord-298503-l60cdllh 375 39 cycle cycle VBP cord-298503-l60cdllh 375 40 through through RB cord-298503-l60cdllh 375 41 and and CC cord-298503-l60cdllh 375 42 define define VB cord-298503-l60cdllh 375 43 a a DT cord-298503-l60cdllh 375 44 subdomain subdomain NN cord-298503-l60cdllh 375 45 of of IN cord-298503-l60cdllh 375 46 the the DT cord-298503-l60cdllh 375 47 intermediate intermediate JJ cord-298503-l60cdllh 375 48 compartment compartment NN cord-298503-l60cdllh 376 1 The the DT cord-298503-l60cdllh 376 2 biogenesis biogenesis NN cord-298503-l60cdllh 376 3 of of IN cord-298503-l60cdllh 376 4 the the DT cord-298503-l60cdllh 376 5 Golgi Golgi NNP cord-298503-l60cdllh 376 6 ribbon ribbon NN cord-298503-l60cdllh 376 7 : : : cord-298503-l60cdllh 376 8 The the DT cord-298503-l60cdllh 376 9 roles role NNS cord-298503-l60cdllh 376 10 of of IN cord-298503-l60cdllh 376 11 membrane membrane NN cord-298503-l60cdllh 376 12 input input NN cord-298503-l60cdllh 376 13 from from IN cord-298503-l60cdllh 376 14 the the DT cord-298503-l60cdllh 376 15 ER ER NNP cord-298503-l60cdllh 376 16 and and CC cord-298503-l60cdllh 376 17 of of IN cord-298503-l60cdllh 376 18 GM130 GM130 NNP cord-298503-l60cdllh 376 19 Vesicular Vesicular NNP cord-298503-l60cdllh 376 20 tubular tubular JJ cord-298503-l60cdllh 376 21 clusters cluster NNS cord-298503-l60cdllh 376 22 between between IN cord-298503-l60cdllh 376 23 the the DT cord-298503-l60cdllh 376 24 ER ER NNP cord-298503-l60cdllh 376 25 and and CC cord-298503-l60cdllh 376 26 Golgi Golgi NNP cord-298503-l60cdllh 376 27 mediate mediate VB cord-298503-l60cdllh 376 28 concentration concentration NN cord-298503-l60cdllh 376 29 of of IN cord-298503-l60cdllh 376 30 soluble soluble JJ cord-298503-l60cdllh 376 31 secretory secretory JJ cord-298503-l60cdllh 376 32 proteins protein NNS cord-298503-l60cdllh 376 33 by by IN cord-298503-l60cdllh 376 34 exclusion exclusion NN cord-298503-l60cdllh 376 35 from from IN cord-298503-l60cdllh 376 36 COPI COPI NNP cord-298503-l60cdllh 376 37 - - HYPH cord-298503-l60cdllh 376 38 coated coat VBN cord-298503-l60cdllh 376 39 vesicles vesicle NNS cord-298503-l60cdllh 376 40 Peri Peri NNP cord-298503-l60cdllh 376 41 - - HYPH cord-298503-l60cdllh 376 42 Golgi Golgi NNP cord-298503-l60cdllh 376 43 vesicles vesicle NNS cord-298503-l60cdllh 376 44 contain contain VBP cord-298503-l60cdllh 376 45 retrograde retrograde JJ cord-298503-l60cdllh 376 46 but but CC cord-298503-l60cdllh 376 47 not not RB cord-298503-l60cdllh 376 48 anterograde anterograde JJ cord-298503-l60cdllh 376 49 proteins protein NNS cord-298503-l60cdllh 376 50 consistent consistent JJ cord-298503-l60cdllh 376 51 with with IN cord-298503-l60cdllh 376 52 the the DT cord-298503-l60cdllh 376 53 cisternal cisternal JJ cord-298503-l60cdllh 376 54 progression progression NN cord-298503-l60cdllh 376 55 model model NN cord-298503-l60cdllh 376 56 of of IN cord-298503-l60cdllh 376 57 intra intra JJ cord-298503-l60cdllh 376 58 - - JJ cord-298503-l60cdllh 376 59 Golgi golgi JJ cord-298503-l60cdllh 376 60 transport transport NN cord-298503-l60cdllh 376 61 Modification modification NN cord-298503-l60cdllh 376 62 of of IN cord-298503-l60cdllh 376 63 intracellular intracellular JJ cord-298503-l60cdllh 376 64 membrane membrane NN cord-298503-l60cdllh 376 65 structures structure NNS cord-298503-l60cdllh 376 66 for for IN cord-298503-l60cdllh 376 67 virus virus NN cord-298503-l60cdllh 376 68 replication replication NN cord-298503-l60cdllh 376 69 ER er NN cord-298503-l60cdllh 376 70 - - HYPH cord-298503-l60cdllh 376 71 to to IN cord-298503-l60cdllh 376 72 - - HYPH cord-298503-l60cdllh 376 73 Golgi golgi NN cord-298503-l60cdllh 376 74 carriers carrier NNS cord-298503-l60cdllh 376 75 arise arise VBP cord-298503-l60cdllh 376 76 through through IN cord-298503-l60cdllh 376 77 direct direct JJ cord-298503-l60cdllh 376 78 en en FW cord-298503-l60cdllh 376 79 bloc bloc NNP cord-298503-l60cdllh 376 80 protrusion protrusion NN cord-298503-l60cdllh 376 81 and and CC cord-298503-l60cdllh 376 82 multistage multistage NN cord-298503-l60cdllh 376 83 maturation maturation NN cord-298503-l60cdllh 376 84 of of IN cord-298503-l60cdllh 376 85 specialized specialized JJ cord-298503-l60cdllh 376 86 ER ER NNP cord-298503-l60cdllh 376 87 exit exit NN cord-298503-l60cdllh 376 88 domains domain NNS cord-298503-l60cdllh 377 1 Phosphatidylinositol Phosphatidylinositol NNP cord-298503-l60cdllh 377 2 3-phosphatase 3-phosphatase CD cord-298503-l60cdllh 377 3 myotubularin myotubularin NN cord-298503-l60cdllh 377 4 - - HYPH cord-298503-l60cdllh 377 5 related relate VBN cord-298503-l60cdllh 377 6 protein protein NN cord-298503-l60cdllh 377 7 6 6 CD cord-298503-l60cdllh 377 8 ( ( -LRB- cord-298503-l60cdllh 377 9 MTMR6 MTMR6 NNP cord-298503-l60cdllh 377 10 ) ) -RRB- cord-298503-l60cdllh 377 11 is be VBZ cord-298503-l60cdllh 377 12 regulated regulate VBN cord-298503-l60cdllh 377 13 by by IN cord-298503-l60cdllh 377 14 small small JJ cord-298503-l60cdllh 377 15 GTPase GTPase NNP cord-298503-l60cdllh 377 16 Rab1B rab1b NN cord-298503-l60cdllh 377 17 in in IN cord-298503-l60cdllh 377 18 the the DT cord-298503-l60cdllh 377 19 early early JJ cord-298503-l60cdllh 377 20 secretory secretory NN cord-298503-l60cdllh 377 21 and and CC cord-298503-l60cdllh 377 22 autophagic autophagic JJ cord-298503-l60cdllh 377 23 pathways pathway NNS cord-298503-l60cdllh 377 24 Rab1B Rab1B NNP cord-298503-l60cdllh 377 25 interacts interact VBZ cord-298503-l60cdllh 377 26 with with IN cord-298503-l60cdllh 377 27 GBF1 GBF1 NNP cord-298503-l60cdllh 377 28 and and CC cord-298503-l60cdllh 377 29 modulates modulate VBZ cord-298503-l60cdllh 377 30 both both DT cord-298503-l60cdllh 377 31 ARF1 ARF1 NNP cord-298503-l60cdllh 377 32 dynamics dynamic NNS cord-298503-l60cdllh 377 33 and and CC cord-298503-l60cdllh 377 34 COPI COPI NNP cord-298503-l60cdllh 377 35 association association NN cord-298503-l60cdllh 378 1 The the DT cord-298503-l60cdllh 378 2 golgin golgin NN cord-298503-l60cdllh 378 3 coiled coil VBN cord-298503-l60cdllh 378 4 - - HYPH cord-298503-l60cdllh 378 5 coil coil NN cord-298503-l60cdllh 378 6 proteins protein NNS cord-298503-l60cdllh 378 7 of of IN cord-298503-l60cdllh 378 8 the the DT cord-298503-l60cdllh 378 9 Golgi Golgi NNP cord-298503-l60cdllh 378 10 apparatus apparatus NN cord-298503-l60cdllh 378 11 A a DT cord-298503-l60cdllh 378 12 C c NN cord-298503-l60cdllh 378 13 - - HYPH cord-298503-l60cdllh 378 14 terminal terminal NN cord-298503-l60cdllh 378 15 signal signal NN cord-298503-l60cdllh 378 16 prevents prevent VBZ cord-298503-l60cdllh 378 17 secretion secretion NN cord-298503-l60cdllh 378 18 of of IN cord-298503-l60cdllh 378 19 luminal luminal JJ cord-298503-l60cdllh 378 20 ER er NN cord-298503-l60cdllh 378 21 proteins protein NNS cord-298503-l60cdllh 378 22 ER er NN cord-298503-l60cdllh 378 23 - - HYPH cord-298503-l60cdllh 378 24 to to IN cord-298503-l60cdllh 378 25 - - HYPH cord-298503-l60cdllh 378 26 Golgi golgi NN cord-298503-l60cdllh 378 27 transport transport NN cord-298503-l60cdllh 378 28 and and CC cord-298503-l60cdllh 378 29 cytoskeletal cytoskeletal JJ cord-298503-l60cdllh 378 30 interactions interaction NNS cord-298503-l60cdllh 378 31 in in IN cord-298503-l60cdllh 378 32 animal animal NN cord-298503-l60cdllh 378 33 cells cell NNS cord-298503-l60cdllh 378 34 Oligomerization Oligomerization NNP cord-298503-l60cdllh 378 35 and and CC cord-298503-l60cdllh 378 36 interacellular interacellular JJ cord-298503-l60cdllh 378 37 localization localization NN cord-298503-l60cdllh 378 38 of of IN cord-298503-l60cdllh 378 39 the the DT cord-298503-l60cdllh 378 40 glycoprotein glycoprotein NN cord-298503-l60cdllh 378 41 receptor receptor NN cord-298503-l60cdllh 378 42 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 378 43 is be VBZ cord-298503-l60cdllh 378 44 independent independent JJ cord-298503-l60cdllh 378 45 of of IN cord-298503-l60cdllh 378 46 disulfide disulfide JJ cord-298503-l60cdllh 378 47 bonds bond NNS cord-298503-l60cdllh 378 48 Mutations Mutations NNPS cord-298503-l60cdllh 378 49 in in IN cord-298503-l60cdllh 378 50 the the DT cord-298503-l60cdllh 378 51 ER ER NNP cord-298503-l60cdllh 378 52 - - HYPH cord-298503-l60cdllh 378 53 Golgi Golgi NNP cord-298503-l60cdllh 378 54 intermediate intermediate JJ cord-298503-l60cdllh 378 55 compartment compartment NN cord-298503-l60cdllh 378 56 protein protein NN cord-298503-l60cdllh 378 57 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 378 58 cause cause NN cord-298503-l60cdllh 379 1 combined combined JJ cord-298503-l60cdllh 379 2 deficiency deficiency NN cord-298503-l60cdllh 379 3 of of IN cord-298503-l60cdllh 379 4 coagulation coagulation NN cord-298503-l60cdllh 379 5 factors factor NNS cord-298503-l60cdllh 379 6 V v NN cord-298503-l60cdllh 379 7 and and CC cord-298503-l60cdllh 379 8 VIII VIII NNP cord-298503-l60cdllh 379 9 Short short JJ cord-298503-l60cdllh 379 10 cytoplasmic cytoplasmic JJ cord-298503-l60cdllh 379 11 sequences sequence NNS cord-298503-l60cdllh 379 12 serve serve VBP cord-298503-l60cdllh 379 13 as as IN cord-298503-l60cdllh 379 14 retention retention NN cord-298503-l60cdllh 379 15 signals signal NNS cord-298503-l60cdllh 379 16 for for IN cord-298503-l60cdllh 379 17 transmembrane transmembrane NN cord-298503-l60cdllh 379 18 proteins protein NNS cord-298503-l60cdllh 379 19 in in IN cord-298503-l60cdllh 379 20 the the DT cord-298503-l60cdllh 379 21 endoplasmic endoplasmic NN cord-298503-l60cdllh 379 22 reticulum reticulum NN cord-298503-l60cdllh 379 23 Dynamics dynamic NNS cord-298503-l60cdllh 379 24 of of IN cord-298503-l60cdllh 379 25 GBF1 GBF1 NNP cord-298503-l60cdllh 379 26 , , , cord-298503-l60cdllh 379 27 a a DT cord-298503-l60cdllh 379 28 brefeldin brefeldin NNP cord-298503-l60cdllh 379 29 A A NNP cord-298503-l60cdllh 379 30 - - HYPH cord-298503-l60cdllh 379 31 sensitive sensitive JJ cord-298503-l60cdllh 379 32 Arf1 Arf1 NNP cord-298503-l60cdllh 379 33 exchange exchange NN cord-298503-l60cdllh 379 34 factor factor NN cord-298503-l60cdllh 379 35 at at IN cord-298503-l60cdllh 379 36 the the DT cord-298503-l60cdllh 379 37 Golgi Golgi NNP cord-298503-l60cdllh 380 1 The the DT cord-298503-l60cdllh 380 2 cargo cargo NN cord-298503-l60cdllh 380 3 receptor receptor NN cord-298503-l60cdllh 380 4 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 380 5 is be VBZ cord-298503-l60cdllh 380 6 a a DT cord-298503-l60cdllh 380 7 target target NN cord-298503-l60cdllh 380 8 of of IN cord-298503-l60cdllh 380 9 the the DT cord-298503-l60cdllh 380 10 unfolded unfolded JJ cord-298503-l60cdllh 380 11 protein protein NN cord-298503-l60cdllh 380 12 response response NN cord-298503-l60cdllh 380 13 Beta beta NN cord-298503-l60cdllh 380 14 - - HYPH cord-298503-l60cdllh 380 15 COP cop NN cord-298503-l60cdllh 380 16 localizes localize VBZ cord-298503-l60cdllh 380 17 mainly mainly RB cord-298503-l60cdllh 380 18 to to IN cord-298503-l60cdllh 380 19 the the DT cord-298503-l60cdllh 380 20 cis cis NNP cord-298503-l60cdllh 380 21 - - HYPH cord-298503-l60cdllh 380 22 Golgi Golgi NNP cord-298503-l60cdllh 380 23 side side NN cord-298503-l60cdllh 380 24 in in IN cord-298503-l60cdllh 380 25 exocrine exocrine JJ cord-298503-l60cdllh 380 26 pancreas pancrea NNS cord-298503-l60cdllh 381 1 The the DT cord-298503-l60cdllh 381 2 ER ER NNP cord-298503-l60cdllh 381 3 - - HYPH cord-298503-l60cdllh 381 4 to to IN cord-298503-l60cdllh 381 5 - - HYPH cord-298503-l60cdllh 381 6 Golgi golgi NN cord-298503-l60cdllh 381 7 interface interface NN cord-298503-l60cdllh 381 8 is be VBZ cord-298503-l60cdllh 381 9 the the DT cord-298503-l60cdllh 381 10 major major JJ cord-298503-l60cdllh 381 11 concentration concentration NN cord-298503-l60cdllh 381 12 site site NN cord-298503-l60cdllh 381 13 of of IN cord-298503-l60cdllh 381 14 secretory secretory JJ cord-298503-l60cdllh 381 15 proteins protein NNS cord-298503-l60cdllh 381 16 in in IN cord-298503-l60cdllh 381 17 the the DT cord-298503-l60cdllh 381 18 exocrine exocrine JJ cord-298503-l60cdllh 381 19 pancreatic pancreatic JJ cord-298503-l60cdllh 381 20 cell cell NN cord-298503-l60cdllh 381 21 Bidirectional bidirectional JJ cord-298503-l60cdllh 381 22 transport transport NN cord-298503-l60cdllh 381 23 by by IN cord-298503-l60cdllh 381 24 distinct distinct JJ cord-298503-l60cdllh 381 25 populations population NNS cord-298503-l60cdllh 381 26 of of IN cord-298503-l60cdllh 381 27 COPI COPI NNP cord-298503-l60cdllh 381 28 - - HYPH cord-298503-l60cdllh 381 29 coated coat VBN cord-298503-l60cdllh 381 30 vesicles vesicle NNS cord-298503-l60cdllh 382 1 The the DT cord-298503-l60cdllh 382 2 role role NN cord-298503-l60cdllh 382 3 of of IN cord-298503-l60cdllh 382 4 microtubules microtubule NNS cord-298503-l60cdllh 382 5 in in IN cord-298503-l60cdllh 382 6 transport transport NN cord-298503-l60cdllh 382 7 between between IN cord-298503-l60cdllh 382 8 the the DT cord-298503-l60cdllh 382 9 endoplasmic endoplasmic NN cord-298503-l60cdllh 382 10 reticulum reticulum NN cord-298503-l60cdllh 382 11 and and CC cord-298503-l60cdllh 382 12 Golgi Golgi NNP cord-298503-l60cdllh 382 13 apparatus apparatus NN cord-298503-l60cdllh 382 14 in in IN cord-298503-l60cdllh 382 15 mammalian mammalian JJ cord-298503-l60cdllh 382 16 cells cell NNS cord-298503-l60cdllh 382 17 Retrograde retrograde JJ cord-298503-l60cdllh 382 18 transport transport NN cord-298503-l60cdllh 382 19 from from IN cord-298503-l60cdllh 382 20 the the DT cord-298503-l60cdllh 382 21 pre pre JJ cord-298503-l60cdllh 382 22 - - JJ cord-298503-l60cdllh 382 23 Golgi Golgi NNP cord-298503-l60cdllh 382 24 intermediate intermediate JJ cord-298503-l60cdllh 382 25 compartment compartment NN cord-298503-l60cdllh 382 26 and and CC cord-298503-l60cdllh 382 27 the the DT cord-298503-l60cdllh 382 28 Golgi Golgi NNP cord-298503-l60cdllh 382 29 complex complex NN cord-298503-l60cdllh 382 30 is be VBZ cord-298503-l60cdllh 382 31 affected affect VBN cord-298503-l60cdllh 382 32 by by IN cord-298503-l60cdllh 382 33 the the DT cord-298503-l60cdllh 382 34 vacuolar vacuolar NNP cord-298503-l60cdllh 383 1 H h NN cord-298503-l60cdllh 384 1 þ þ NNP cord-298503-l60cdllh 385 1 -ATPase -ATPase NNP cord-298503-l60cdllh 386 1 inhibitor inhibitor NN cord-298503-l60cdllh 386 2 bafilomycin bafilomycin NNP cord-298503-l60cdllh 386 3 A1 A1 NNP cord-298503-l60cdllh 387 1 The the DT cord-298503-l60cdllh 387 2 pH ph NN cord-298503-l60cdllh 387 3 of of IN cord-298503-l60cdllh 387 4 the the DT cord-298503-l60cdllh 387 5 secretory secretory JJ cord-298503-l60cdllh 387 6 pathway pathway NN cord-298503-l60cdllh 387 7 : : : cord-298503-l60cdllh 388 1 Measurement measurement NN cord-298503-l60cdllh 388 2 , , , cord-298503-l60cdllh 388 3 determinants determinant NNS cord-298503-l60cdllh 388 4 , , , cord-298503-l60cdllh 388 5 and and CC cord-298503-l60cdllh 388 6 regulation regulation NN cord-298503-l60cdllh 388 7 Evidence evidence NN cord-298503-l60cdllh 388 8 that that IN cord-298503-l60cdllh 388 9 luminal luminal JJ cord-298503-l60cdllh 388 10 ER er NN cord-298503-l60cdllh 388 11 proteins protein NNS cord-298503-l60cdllh 388 12 are be VBP cord-298503-l60cdllh 388 13 sorted sort VBN cord-298503-l60cdllh 388 14 from from IN cord-298503-l60cdllh 388 15 secreted secreted JJ cord-298503-l60cdllh 388 16 proteins protein NNS cord-298503-l60cdllh 388 17 in in IN cord-298503-l60cdllh 388 18 a a DT cord-298503-l60cdllh 388 19 post post JJ cord-298503-l60cdllh 388 20 - - JJ cord-298503-l60cdllh 388 21 ER er JJ cord-298503-l60cdllh 388 22 compartment compartment NN cord-298503-l60cdllh 388 23 Control control NN cord-298503-l60cdllh 388 24 of of IN cord-298503-l60cdllh 388 25 protein protein NN cord-298503-l60cdllh 388 26 exit exit NN cord-298503-l60cdllh 388 27 from from IN cord-298503-l60cdllh 388 28 the the DT cord-298503-l60cdllh 388 29 endoplasmic endoplasmic NN cord-298503-l60cdllh 388 30 reticulum reticulum NN cord-298503-l60cdllh 388 31 Beta beta NN cord-298503-l60cdllh 388 32 - - HYPH cord-298503-l60cdllh 388 33 COP cop NN cord-298503-l60cdllh 388 34 is be VBZ cord-298503-l60cdllh 388 35 essential essential JJ cord-298503-l60cdllh 388 36 for for IN cord-298503-l60cdllh 388 37 biosynthetic biosynthetic JJ cord-298503-l60cdllh 388 38 membrane membrane NN cord-298503-l60cdllh 388 39 transport transport NN cord-298503-l60cdllh 388 40 from from IN cord-298503-l60cdllh 388 41 the the DT cord-298503-l60cdllh 388 42 endoplasmic endoplasmic NN cord-298503-l60cdllh 388 43 reticulum reticulum NN cord-298503-l60cdllh 388 44 to to IN cord-298503-l60cdllh 388 45 the the DT cord-298503-l60cdllh 388 46 Golgi Golgi NNP cord-298503-l60cdllh 388 47 complex complex NN cord-298503-l60cdllh 388 48 in in IN cord-298503-l60cdllh 388 49 vivo vivo NNP cord-298503-l60cdllh 388 50 β β NN cord-298503-l60cdllh 388 51 - - HYPH cord-298503-l60cdllh 388 52 COP COP NNP cord-298503-l60cdllh 388 53 is be VBZ cord-298503-l60cdllh 388 54 essential essential JJ cord-298503-l60cdllh 388 55 for for IN cord-298503-l60cdllh 388 56 transport transport NN cord-298503-l60cdllh 388 57 of of IN cord-298503-l60cdllh 388 58 protein protein NN cord-298503-l60cdllh 388 59 from from IN cord-298503-l60cdllh 388 60 the the DT cord-298503-l60cdllh 388 61 endoplasmic endoplasmic NN cord-298503-l60cdllh 388 62 reticulum reticulum NN cord-298503-l60cdllh 388 63 to to IN cord-298503-l60cdllh 388 64 the the DT cord-298503-l60cdllh 388 65 Golgi Golgi NNP cord-298503-l60cdllh 388 66 in in IN cord-298503-l60cdllh 388 67 vitro vitro FW cord-298503-l60cdllh 388 68 Rab1b Rab1b NNP cord-298503-l60cdllh 388 69 regulates regulate VBZ cord-298503-l60cdllh 388 70 vesicular vesicular JJ cord-298503-l60cdllh 388 71 transport transport NN cord-298503-l60cdllh 388 72 between between IN cord-298503-l60cdllh 388 73 the the DT cord-298503-l60cdllh 388 74 endoplasmic endoplasmic NN cord-298503-l60cdllh 388 75 reticulum reticulum NN cord-298503-l60cdllh 388 76 and and CC cord-298503-l60cdllh 388 77 successive successive JJ cord-298503-l60cdllh 388 78 Golgi Golgi NNP cord-298503-l60cdllh 388 79 compartments compartment NNS cord-298503-l60cdllh 389 1 Morphological morphological JJ cord-298503-l60cdllh 389 2 analysis analysis NN cord-298503-l60cdllh 389 3 of of IN cord-298503-l60cdllh 389 4 protein protein NN cord-298503-l60cdllh 389 5 transport transport NN cord-298503-l60cdllh 389 6 from from IN cord-298503-l60cdllh 389 7 the the DT cord-298503-l60cdllh 389 8 ER ER NNP cord-298503-l60cdllh 389 9 to to IN cord-298503-l60cdllh 389 10 Golgi Golgi NNP cord-298503-l60cdllh 389 11 membranes membrane NNS cord-298503-l60cdllh 389 12 in in IN cord-298503-l60cdllh 389 13 digitonin digitonin NN cord-298503-l60cdllh 389 14 - - HYPH cord-298503-l60cdllh 389 15 permeabilized permeabilize VBN cord-298503-l60cdllh 389 16 cells cell NNS cord-298503-l60cdllh 389 17 : : : cord-298503-l60cdllh 390 1 Role role NN cord-298503-l60cdllh 390 2 of of IN cord-298503-l60cdllh 390 3 the the DT cord-298503-l60cdllh 390 4 p58-containing p58-containing NN cord-298503-l60cdllh 390 5 compartment compartment NN cord-298503-l60cdllh 391 1 Several several JJ cord-298503-l60cdllh 391 2 ADP ADP NNP cord-298503-l60cdllh 391 3 - - HYPH cord-298503-l60cdllh 391 4 ribosylation ribosylation NN cord-298503-l60cdllh 391 5 factor factor NN cord-298503-l60cdllh 391 6 ( ( -LRB- cord-298503-l60cdllh 391 7 Arf Arf NNP cord-298503-l60cdllh 391 8 ) ) -RRB- cord-298503-l60cdllh 391 9 isoforms isoform NNS cord-298503-l60cdllh 391 10 support support VBP cord-298503-l60cdllh 391 11 COPI COPI NNP cord-298503-l60cdllh 391 12 vesicle vesicle NN cord-298503-l60cdllh 391 13 formation formation NN cord-298503-l60cdllh 391 14 Dissection dissection NN cord-298503-l60cdllh 391 15 of of IN cord-298503-l60cdllh 391 16 COPI COPI NNP cord-298503-l60cdllh 391 17 and and CC cord-298503-l60cdllh 391 18 Arf1 Arf1 NNP cord-298503-l60cdllh 391 19 dynamics dynamic NNS cord-298503-l60cdllh 391 20 in in IN cord-298503-l60cdllh 391 21 vivo vivo NN cord-298503-l60cdllh 391 22 and and CC cord-298503-l60cdllh 391 23 role role NN cord-298503-l60cdllh 391 24 in in IN cord-298503-l60cdllh 391 25 Golgi Golgi NNP cord-298503-l60cdllh 391 26 membrane membrane NN cord-298503-l60cdllh 391 27 transport transport NN cord-298503-l60cdllh 391 28 ER er NN cord-298503-l60cdllh 391 29 - - HYPH cord-298503-l60cdllh 391 30 to to IN cord-298503-l60cdllh 391 31 - - HYPH cord-298503-l60cdllh 391 32 Golgi golgi NN cord-298503-l60cdllh 391 33 transport transport NN cord-298503-l60cdllh 391 34 visualized visualize VBN cord-298503-l60cdllh 391 35 in in IN cord-298503-l60cdllh 391 36 living living NN cord-298503-l60cdllh 391 37 cells cell NNS cord-298503-l60cdllh 391 38 Golgi Golgi NNP cord-298503-l60cdllh 391 39 membrane membrane NN cord-298503-l60cdllh 391 40 dynamics dynamic NNS cord-298503-l60cdllh 392 1 The the DT cord-298503-l60cdllh 392 2 maturing mature VBG cord-298503-l60cdllh 392 3 role role NN cord-298503-l60cdllh 392 4 of of IN cord-298503-l60cdllh 392 5 COPI COPI NNP cord-298503-l60cdllh 392 6 vesicles vesicle NNS cord-298503-l60cdllh 392 7 in in IN cord-298503-l60cdllh 392 8 intra intra JJ cord-298503-l60cdllh 392 9 - - JJ cord-298503-l60cdllh 392 10 Golgi golgi JJ cord-298503-l60cdllh 392 11 transport transport NN cord-298503-l60cdllh 392 12 Three three CD cord-298503-l60cdllh 392 13 - - HYPH cord-298503-l60cdllh 392 14 dimensional dimensional JJ cord-298503-l60cdllh 392 15 structure structure NN cord-298503-l60cdllh 392 16 of of IN cord-298503-l60cdllh 392 17 the the DT cord-298503-l60cdllh 392 18 osmium osmium NN cord-298503-l60cdllh 392 19 - - HYPH cord-298503-l60cdllh 392 20 impregnated impregnate VBN cord-298503-l60cdllh 392 21 Golgi Golgi NNP cord-298503-l60cdllh 392 22 apparatus apparatus NN cord-298503-l60cdllh 392 23 as as IN cord-298503-l60cdllh 392 24 seen see VBN cord-298503-l60cdllh 392 25 in in IN cord-298503-l60cdllh 392 26 the the DT cord-298503-l60cdllh 392 27 high high JJ cord-298503-l60cdllh 392 28 voltage voltage NN cord-298503-l60cdllh 392 29 electron electron NN cord-298503-l60cdllh 392 30 microscope microscope NN cord-298503-l60cdllh 393 1 Misfolded misfolded JJ cord-298503-l60cdllh 393 2 major major JJ cord-298503-l60cdllh 393 3 histocompatibility histocompatibility NN cord-298503-l60cdllh 393 4 complex complex JJ cord-298503-l60cdllh 393 5 class class NN cord-298503-l60cdllh 394 1 I -PRON- PRP cord-298503-l60cdllh 394 2 molecules molecule NNS cord-298503-l60cdllh 394 3 accumulate accumulate VBP cord-298503-l60cdllh 394 4 in in IN cord-298503-l60cdllh 394 5 an an DT cord-298503-l60cdllh 394 6 expanded expand VBN cord-298503-l60cdllh 394 7 ER ER NNP cord-298503-l60cdllh 394 8 - - HYPH cord-298503-l60cdllh 394 9 Golgi Golgi NNP cord-298503-l60cdllh 394 10 intermediate intermediate JJ cord-298503-l60cdllh 394 11 compartment compartment NN cord-298503-l60cdllh 394 12 GMAP-210 GMAP-210 NNP cord-298503-l60cdllh 394 13 recruits recruit VBZ cord-298503-l60cdllh 394 14 γ γ NN cord-298503-l60cdllh 394 15 - - HYPH cord-298503-l60cdllh 394 16 tubulin tubulin NN cord-298503-l60cdllh 394 17 complexes complex NNS cord-298503-l60cdllh 394 18 to to IN cord-298503-l60cdllh 394 19 cis cis NNP cord-298503-l60cdllh 394 20 - - HYPH cord-298503-l60cdllh 394 21 Golgi Golgi NNP cord-298503-l60cdllh 394 22 membranes membrane NNS cord-298503-l60cdllh 394 23 and and CC cord-298503-l60cdllh 394 24 is be VBZ cord-298503-l60cdllh 394 25 required require VBN cord-298503-l60cdllh 394 26 for for IN cord-298503-l60cdllh 394 27 Golgi Golgi NNP cord-298503-l60cdllh 394 28 ribbon ribbon NN cord-298503-l60cdllh 394 29 formation formation NN cord-298503-l60cdllh 394 30 Endoplasmic Endoplasmic NNP cord-298503-l60cdllh 394 31 reticulum reticulum NN cord-298503-l60cdllh 394 32 - - : cord-298503-l60cdllh 394 33 Golgi Golgi NNP cord-298503-l60cdllh 394 34 intermediate intermediate JJ cord-298503-l60cdllh 394 35 compartment compartment NN cord-298503-l60cdllh 394 36 membranes membrane NNS cord-298503-l60cdllh 394 37 and and CC cord-298503-l60cdllh 394 38 vimentin vimentin NN cord-298503-l60cdllh 394 39 filaments filament NNS cord-298503-l60cdllh 394 40 participate participate VBP cord-298503-l60cdllh 394 41 in in IN cord-298503-l60cdllh 394 42 vaccinia vaccinia NN cord-298503-l60cdllh 394 43 virus virus NN cord-298503-l60cdllh 394 44 assembly assembly NN cord-298503-l60cdllh 394 45 Dynamic Dynamic NNP cord-298503-l60cdllh 394 46 association association NNP cord-298503-l60cdllh 394 47 of of IN cord-298503-l60cdllh 394 48 cytoplasmic cytoplasmic JJ cord-298503-l60cdllh 394 49 dynein dynein NNP cord-298503-l60cdllh 394 50 heavy heavy JJ cord-298503-l60cdllh 394 51 chain chain NN cord-298503-l60cdllh 394 52 1a 1a CD cord-298503-l60cdllh 394 53 with with IN cord-298503-l60cdllh 394 54 the the DT cord-298503-l60cdllh 394 55 Golgi Golgi NNP cord-298503-l60cdllh 394 56 apparatus apparatus NN cord-298503-l60cdllh 394 57 and and CC cord-298503-l60cdllh 394 58 intermediate intermediate JJ cord-298503-l60cdllh 394 59 compartment compartment NN cord-298503-l60cdllh 394 60 Involvement Involvement NNP cord-298503-l60cdllh 394 61 of of IN cord-298503-l60cdllh 394 62 the the DT cord-298503-l60cdllh 394 63 transmembrane transmembrane NNP cord-298503-l60cdllh 394 64 protein protein NN cord-298503-l60cdllh 394 65 p23 p23 NN cord-298503-l60cdllh 394 66 in in IN cord-298503-l60cdllh 395 1 biosynthetic biosynthetic JJ cord-298503-l60cdllh 395 2 protein protein NN cord-298503-l60cdllh 395 3 transport transport NN cord-298503-l60cdllh 395 4 Golgicide Golgicide NNP cord-298503-l60cdllh 395 5 A A NNP cord-298503-l60cdllh 395 6 reveals reveal VBZ cord-298503-l60cdllh 395 7 essential essential JJ cord-298503-l60cdllh 395 8 roles role NNS cord-298503-l60cdllh 395 9 for for IN cord-298503-l60cdllh 395 10 GBF1 GBF1 NNP cord-298503-l60cdllh 395 11 in in IN cord-298503-l60cdllh 395 12 Golgi Golgi NNP cord-298503-l60cdllh 395 13 assembly assembly NN cord-298503-l60cdllh 395 14 and and CC cord-298503-l60cdllh 395 15 function function NN cord-298503-l60cdllh 396 1 Rab1 rab1 NN cord-298503-l60cdllh 396 2 defines define VBZ cord-298503-l60cdllh 396 3 a a DT cord-298503-l60cdllh 396 4 novel novel JJ cord-298503-l60cdllh 396 5 pathway pathway NN cord-298503-l60cdllh 396 6 connecting connect VBG cord-298503-l60cdllh 396 7 the the DT cord-298503-l60cdllh 396 8 pre pre JJ cord-298503-l60cdllh 396 9 - - JJ cord-298503-l60cdllh 396 10 Golgi Golgi NNP cord-298503-l60cdllh 396 11 intermediate intermediate JJ cord-298503-l60cdllh 396 12 compartment compartment NN cord-298503-l60cdllh 396 13 with with IN cord-298503-l60cdllh 396 14 the the DT cord-298503-l60cdllh 396 15 cell cell NN cord-298503-l60cdllh 396 16 periphery periphery NN cord-298503-l60cdllh 396 17 Emerging emerge VBG cord-298503-l60cdllh 396 18 new new JJ cord-298503-l60cdllh 396 19 roles role NNS cord-298503-l60cdllh 396 20 of of IN cord-298503-l60cdllh 396 21 the the DT cord-298503-l60cdllh 396 22 pre pre JJ cord-298503-l60cdllh 396 23 - - JJ cord-298503-l60cdllh 396 24 Golgi Golgi NNP cord-298503-l60cdllh 396 25 intermediate intermediate JJ cord-298503-l60cdllh 396 26 compartment compartment NN cord-298503-l60cdllh 396 27 in in IN cord-298503-l60cdllh 396 28 biosynthetic biosynthetic JJ cord-298503-l60cdllh 396 29 - - HYPH cord-298503-l60cdllh 396 30 secretory secretory NN cord-298503-l60cdllh 396 31 trafficking traffic VBG cord-298503-l60cdllh 396 32 Functional functional JJ cord-298503-l60cdllh 396 33 symmetry symmetry NN cord-298503-l60cdllh 396 34 of of IN cord-298503-l60cdllh 396 35 endomembranes endomembranes NNP cord-298503-l60cdllh 396 36 Pre Pre NNP cord-298503-l60cdllh 396 37 - - : cord-298503-l60cdllh 396 38 and and CC cord-298503-l60cdllh 396 39 post post JJ cord-298503-l60cdllh 396 40 - - JJ cord-298503-l60cdllh 396 41 Golgi golgi JJ cord-298503-l60cdllh 396 42 vacuoles vacuole NNS cord-298503-l60cdllh 396 43 operate operate VBP cord-298503-l60cdllh 396 44 in in IN cord-298503-l60cdllh 396 45 the the DT cord-298503-l60cdllh 396 46 transport transport NN cord-298503-l60cdllh 396 47 of of IN cord-298503-l60cdllh 396 48 Semliki Semliki NNP cord-298503-l60cdllh 396 49 Forest Forest NNP cord-298503-l60cdllh 396 50 virus virus NN cord-298503-l60cdllh 396 51 membrane membrane NN cord-298503-l60cdllh 396 52 glycoproteins glycoprotein NNS cord-298503-l60cdllh 396 53 to to IN cord-298503-l60cdllh 396 54 the the DT cord-298503-l60cdllh 396 55 cell cell NN cord-298503-l60cdllh 396 56 surface surface NN cord-298503-l60cdllh 396 57 Pathways pathway NNS cord-298503-l60cdllh 396 58 of of IN cord-298503-l60cdllh 396 59 protein protein NN cord-298503-l60cdllh 396 60 sorting sorting NN cord-298503-l60cdllh 396 61 and and CC cord-298503-l60cdllh 396 62 membrane membrane NN cord-298503-l60cdllh 396 63 traffic traffic NN cord-298503-l60cdllh 396 64 between between IN cord-298503-l60cdllh 396 65 the the DT cord-298503-l60cdllh 396 66 rough rough JJ cord-298503-l60cdllh 396 67 endoplasmic endoplasmic NN cord-298503-l60cdllh 396 68 reticulum reticulum NN cord-298503-l60cdllh 396 69 and and CC cord-298503-l60cdllh 396 70 the the DT cord-298503-l60cdllh 396 71 Golgi Golgi NNP cord-298503-l60cdllh 396 72 complex complex NN cord-298503-l60cdllh 396 73 Localization localization NN cord-298503-l60cdllh 396 74 of of IN cord-298503-l60cdllh 396 75 the the DT cord-298503-l60cdllh 396 76 small small JJ cord-298503-l60cdllh 396 77 GTP gtp NN cord-298503-l60cdllh 396 78 - - HYPH cord-298503-l60cdllh 396 79 binding bind VBG cord-298503-l60cdllh 396 80 protein protein NN cord-298503-l60cdllh 396 81 Rab1 Rab1 NNP cord-298503-l60cdllh 396 82 to to IN cord-298503-l60cdllh 396 83 early early JJ cord-298503-l60cdllh 396 84 compartments compartment NNS cord-298503-l60cdllh 396 85 of of IN cord-298503-l60cdllh 396 86 the the DT cord-298503-l60cdllh 396 87 secretory secretory JJ cord-298503-l60cdllh 396 88 pathway pathway NN cord-298503-l60cdllh 396 89 Temperature temperature NN cord-298503-l60cdllh 396 90 - - HYPH cord-298503-l60cdllh 396 91 sensitive sensitive JJ cord-298503-l60cdllh 396 92 steps step NNS cord-298503-l60cdllh 396 93 in in IN cord-298503-l60cdllh 396 94 the the DT cord-298503-l60cdllh 396 95 transport transport NN cord-298503-l60cdllh 396 96 of of IN cord-298503-l60cdllh 396 97 secretory secretory JJ cord-298503-l60cdllh 396 98 proteins protein NNS cord-298503-l60cdllh 396 99 through through IN cord-298503-l60cdllh 396 100 the the DT cord-298503-l60cdllh 396 101 Golgi Golgi NNP cord-298503-l60cdllh 396 102 complex complex NN cord-298503-l60cdllh 396 103 in in IN cord-298503-l60cdllh 396 104 exocrine exocrine JJ cord-298503-l60cdllh 396 105 pancreatic pancreatic NN cord-298503-l60cdllh 396 106 cells cell NNS cord-298503-l60cdllh 396 107 Antibodies antibody NNS cord-298503-l60cdllh 396 108 to to IN cord-298503-l60cdllh 396 109 rat rat NN cord-298503-l60cdllh 396 110 pancreas pancreas NN cord-298503-l60cdllh 396 111 Golgi Golgi NNP cord-298503-l60cdllh 396 112 subfractions subfraction NNS cord-298503-l60cdllh 396 113 : : : cord-298503-l60cdllh 397 1 Identification identification NN cord-298503-l60cdllh 397 2 of of IN cord-298503-l60cdllh 397 3 a a DT cord-298503-l60cdllh 397 4 58 58 CD cord-298503-l60cdllh 397 5 kDa kDa NNP cord-298503-l60cdllh 397 6 cis cis NNP cord-298503-l60cdllh 397 7 - - HYPH cord-298503-l60cdllh 397 8 Golgi Golgi NNP cord-298503-l60cdllh 397 9 protein protein NN cord-298503-l60cdllh 397 10 Distribution distribution NN cord-298503-l60cdllh 397 11 of of IN cord-298503-l60cdllh 397 12 the the DT cord-298503-l60cdllh 397 13 intermediate intermediate JJ cord-298503-l60cdllh 397 14 elements element NNS cord-298503-l60cdllh 397 15 operating operate VBG cord-298503-l60cdllh 397 16 in in IN cord-298503-l60cdllh 397 17 ER ER NNP cord-298503-l60cdllh 397 18 to to IN cord-298503-l60cdllh 397 19 Golgi Golgi NNP cord-298503-l60cdllh 397 20 transport transport NN cord-298503-l60cdllh 397 21 Golgin-84 Golgin-84 NNS cord-298503-l60cdllh 397 22 is be VBZ cord-298503-l60cdllh 397 23 a a DT cord-298503-l60cdllh 397 24 Rab1 Rab1 NNP cord-298503-l60cdllh 397 25 binding binding NN cord-298503-l60cdllh 397 26 partner partner NN cord-298503-l60cdllh 397 27 involved involve VBN cord-298503-l60cdllh 397 28 in in IN cord-298503-l60cdllh 397 29 Golgi Golgi NNP cord-298503-l60cdllh 397 30 structure structure NN cord-298503-l60cdllh 398 1 Intracellular intracellular JJ cord-298503-l60cdllh 398 2 interaction interaction NN cord-298503-l60cdllh 398 3 of of IN cord-298503-l60cdllh 398 4 collagen collagen NN cord-298503-l60cdllh 398 5 - - HYPH cord-298503-l60cdllh 398 6 specific specific JJ cord-298503-l60cdllh 398 7 stress stress NN cord-298503-l60cdllh 398 8 protein protein NN cord-298503-l60cdllh 398 9 HSP47 HSP47 NNP cord-298503-l60cdllh 398 10 with with IN cord-298503-l60cdllh 398 11 newly newly RB cord-298503-l60cdllh 398 12 synthesized synthesize VBN cord-298503-l60cdllh 398 13 procollagen procollagen NN cord-298503-l60cdllh 398 14 Visualization visualization NN cord-298503-l60cdllh 398 15 of of IN cord-298503-l60cdllh 398 16 ER ER NNP cord-298503-l60cdllh 398 17 - - HYPH cord-298503-l60cdllh 398 18 to to IN cord-298503-l60cdllh 398 19 - - HYPH cord-298503-l60cdllh 398 20 Golgi golgi NN cord-298503-l60cdllh 398 21 transport transport NN cord-298503-l60cdllh 398 22 in in IN cord-298503-l60cdllh 398 23 living living NN cord-298503-l60cdllh 398 24 cells cell NNS cord-298503-l60cdllh 398 25 reveals reveal VBZ cord-298503-l60cdllh 398 26 a a DT cord-298503-l60cdllh 398 27 sequential sequential JJ cord-298503-l60cdllh 398 28 mode mode NN cord-298503-l60cdllh 398 29 of of IN cord-298503-l60cdllh 398 30 action action NN cord-298503-l60cdllh 398 31 for for IN cord-298503-l60cdllh 398 32 COPII COPII NNP cord-298503-l60cdllh 398 33 and and CC cord-298503-l60cdllh 398 34 COPI COPI NNP cord-298503-l60cdllh 398 35 Trk Trk NNP cord-298503-l60cdllh 398 36 activation activation NN cord-298503-l60cdllh 398 37 in in IN cord-298503-l60cdllh 398 38 the the DT cord-298503-l60cdllh 398 39 secretory secretory JJ cord-298503-l60cdllh 398 40 pathway pathway NN cord-298503-l60cdllh 398 41 promotes promote VBZ cord-298503-l60cdllh 398 42 Golgi Golgi NNP cord-298503-l60cdllh 398 43 fragmentation fragmentation NN cord-298503-l60cdllh 399 1 The the DT cord-298503-l60cdllh 399 2 absence absence NN cord-298503-l60cdllh 399 3 of of IN cord-298503-l60cdllh 399 4 Emp24p Emp24p NNP cord-298503-l60cdllh 399 5 , , , cord-298503-l60cdllh 399 6 a a DT cord-298503-l60cdllh 399 7 component component NN cord-298503-l60cdllh 399 8 of of IN cord-298503-l60cdllh 399 9 ER ER NNP cord-298503-l60cdllh 399 10 - - HYPH cord-298503-l60cdllh 399 11 derived derive VBN cord-298503-l60cdllh 399 12 COPII COPII NNP cord-298503-l60cdllh 399 13 - - HYPH cord-298503-l60cdllh 399 14 coated coat VBN cord-298503-l60cdllh 399 15 vesicles vesicle NNS cord-298503-l60cdllh 399 16 , , , cord-298503-l60cdllh 399 17 causes cause VBZ cord-298503-l60cdllh 399 18 a a DT cord-298503-l60cdllh 399 19 defect defect NN cord-298503-l60cdllh 399 20 in in IN cord-298503-l60cdllh 399 21 transport transport NN cord-298503-l60cdllh 399 22 of of IN cord-298503-l60cdllh 399 23 selected select VBN cord-298503-l60cdllh 399 24 proteins protein NNS cord-298503-l60cdllh 399 25 to to IN cord-298503-l60cdllh 399 26 the the DT cord-298503-l60cdllh 399 27 Golgi Golgi NNP cord-298503-l60cdllh 399 28 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 399 29 , , , cord-298503-l60cdllh 399 30 a a DT cord-298503-l60cdllh 399 31 membrane membrane NN cord-298503-l60cdllh 399 32 protein protein NN cord-298503-l60cdllh 399 33 of of IN cord-298503-l60cdllh 399 34 the the DT cord-298503-l60cdllh 399 35 ER ER NNP cord-298503-l60cdllh 399 36 - - HYPH cord-298503-l60cdllh 399 37 Golgi Golgi NNP cord-298503-l60cdllh 399 38 intermediate intermediate JJ cord-298503-l60cdllh 399 39 compartment compartment NN cord-298503-l60cdllh 399 40 , , , cord-298503-l60cdllh 399 41 carries carry VBZ cord-298503-l60cdllh 399 42 an an DT cord-298503-l60cdllh 399 43 ER ER NNP cord-298503-l60cdllh 399 44 retention retention NN cord-298503-l60cdllh 399 45 motif motif NN cord-298503-l60cdllh 399 46 Identification identification NN cord-298503-l60cdllh 399 47 , , , cord-298503-l60cdllh 399 48 by by IN cord-298503-l60cdllh 399 49 a a DT cord-298503-l60cdllh 399 50 monoclonal monoclonal JJ cord-298503-l60cdllh 399 51 antibody antibody NN cord-298503-l60cdllh 399 52 , , , cord-298503-l60cdllh 399 53 of of IN cord-298503-l60cdllh 399 54 a a DT cord-298503-l60cdllh 399 55 53-kD 53-kd CD cord-298503-l60cdllh 399 56 protein protein NN cord-298503-l60cdllh 399 57 associated associate VBN cord-298503-l60cdllh 399 58 with with IN cord-298503-l60cdllh 399 59 a a DT cord-298503-l60cdllh 399 60 tubulo tubulo JJ cord-298503-l60cdllh 399 61 - - HYPH cord-298503-l60cdllh 399 62 vesicular vesicular JJ cord-298503-l60cdllh 399 63 compartment compartment NN cord-298503-l60cdllh 399 64 at at IN cord-298503-l60cdllh 399 65 the the DT cord-298503-l60cdllh 399 66 cis cis NNP cord-298503-l60cdllh 399 67 - - HYPH cord-298503-l60cdllh 399 68 side side NN cord-298503-l60cdllh 399 69 of of IN cord-298503-l60cdllh 399 70 the the DT cord-298503-l60cdllh 399 71 Golgi Golgi NNP cord-298503-l60cdllh 399 72 apparatus apparatus NN cord-298503-l60cdllh 399 73 Identification identification NN cord-298503-l60cdllh 399 74 of of IN cord-298503-l60cdllh 399 75 an an DT cord-298503-l60cdllh 399 76 intermediate intermediate JJ cord-298503-l60cdllh 399 77 compartment compartment NN cord-298503-l60cdllh 399 78 involved involve VBN cord-298503-l60cdllh 399 79 in in IN cord-298503-l60cdllh 399 80 protein protein NN cord-298503-l60cdllh 399 81 transport transport NN cord-298503-l60cdllh 399 82 from from IN cord-298503-l60cdllh 399 83 endoplasmic endoplasmic NN cord-298503-l60cdllh 399 84 reticulum reticulum NN cord-298503-l60cdllh 399 85 to to IN cord-298503-l60cdllh 399 86 Golgi Golgi NNP cord-298503-l60cdllh 399 87 apparatus apparatus NN cord-298503-l60cdllh 399 88 Ypt Ypt NNP cord-298503-l60cdllh 399 89 and and CC cord-298503-l60cdllh 399 90 Rab Rab NNP cord-298503-l60cdllh 399 91 GTPases gtpase NNS cord-298503-l60cdllh 399 92 : : : cord-298503-l60cdllh 400 1 Insight insight NN cord-298503-l60cdllh 400 2 into into IN cord-298503-l60cdllh 400 3 functions function NNS cord-298503-l60cdllh 400 4 through through IN cord-298503-l60cdllh 400 5 novel novel JJ cord-298503-l60cdllh 400 6 interactions interaction NNS cord-298503-l60cdllh 401 1 A a DT cord-298503-l60cdllh 401 2 three three CD cord-298503-l60cdllh 401 3 - - HYPH cord-298503-l60cdllh 401 4 dimensional dimensional JJ cord-298503-l60cdllh 401 5 reconstruction reconstruction NN cord-298503-l60cdllh 401 6 study study NN cord-298503-l60cdllh 401 7 of of IN cord-298503-l60cdllh 401 8 the the DT cord-298503-l60cdllh 401 9 rough rough JJ cord-298503-l60cdllh 401 10 ER ER NNP cord-298503-l60cdllh 401 11 - - HYPH cord-298503-l60cdllh 401 12 Golgi golgi NN cord-298503-l60cdllh 401 13 interface interface NN cord-298503-l60cdllh 401 14 in in IN cord-298503-l60cdllh 401 15 serial serial JJ cord-298503-l60cdllh 401 16 thin thin JJ cord-298503-l60cdllh 401 17 sections section NNS cord-298503-l60cdllh 401 18 of of IN cord-298503-l60cdllh 401 19 the the DT cord-298503-l60cdllh 401 20 pancreatic pancreatic JJ cord-298503-l60cdllh 401 21 acinar acinar JJ cord-298503-l60cdllh 401 22 cell cell NN cord-298503-l60cdllh 401 23 of of IN cord-298503-l60cdllh 401 24 the the DT cord-298503-l60cdllh 401 25 rat rat NN cord-298503-l60cdllh 401 26 Segregation Segregation NNP cord-298503-l60cdllh 401 27 of of IN cord-298503-l60cdllh 401 28 COPI COPI NNP cord-298503-l60cdllh 401 29 - - HYPH cord-298503-l60cdllh 401 30 rich rich JJ cord-298503-l60cdllh 401 31 and and CC cord-298503-l60cdllh 401 32 anterograde anterograde JJ cord-298503-l60cdllh 401 33 - - HYPH cord-298503-l60cdllh 401 34 cargo cargo NN cord-298503-l60cdllh 401 35 - - HYPH cord-298503-l60cdllh 401 36 rich rich JJ cord-298503-l60cdllh 401 37 domains domain NNS cord-298503-l60cdllh 401 38 in in IN cord-298503-l60cdllh 401 39 endoplasmic endoplasmic NN cord-298503-l60cdllh 401 40 - - HYPH cord-298503-l60cdllh 401 41 reticulum reticulum NN cord-298503-l60cdllh 401 42 - - HYPH cord-298503-l60cdllh 401 43 to to IN cord-298503-l60cdllh 401 44 - - HYPH cord-298503-l60cdllh 401 45 Golgi golgi NN cord-298503-l60cdllh 401 46 transport transport NN cord-298503-l60cdllh 401 47 complexes complex NNS cord-298503-l60cdllh 401 48 A a DT cord-298503-l60cdllh 401 49 GRASP55-rab2 grasp55-rab2 CD cord-298503-l60cdllh 401 50 effector effector NN cord-298503-l60cdllh 401 51 complex complex NN cord-298503-l60cdllh 401 52 linking link VBG cord-298503-l60cdllh 401 53 Golgi Golgi NNP cord-298503-l60cdllh 401 54 structure structure NN cord-298503-l60cdllh 401 55 to to IN cord-298503-l60cdllh 401 56 membrane membrane NN cord-298503-l60cdllh 401 57 traffic traffic NN cord-298503-l60cdllh 401 58 Biogenesis biogenesis NN cord-298503-l60cdllh 401 59 of of IN cord-298503-l60cdllh 401 60 tubular tubular JJ cord-298503-l60cdllh 401 61 ER er NN cord-298503-l60cdllh 401 62 - - HYPH cord-298503-l60cdllh 401 63 to to IN cord-298503-l60cdllh 401 64 - - HYPH cord-298503-l60cdllh 401 65 Golgi golgi NN cord-298503-l60cdllh 401 66 transport transport NN cord-298503-l60cdllh 401 67 intermediates intermediate NNS cord-298503-l60cdllh 402 1 Golgi Golgi NNP cord-298503-l60cdllh 402 2 coiled coil VBN cord-298503-l60cdllh 402 3 - - HYPH cord-298503-l60cdllh 402 4 coil coil NN cord-298503-l60cdllh 402 5 proteins protein NNS cord-298503-l60cdllh 402 6 contain contain VBP cord-298503-l60cdllh 402 7 multiple multiple JJ cord-298503-l60cdllh 402 8 binding bind VBG cord-298503-l60cdllh 402 9 sites site NNS cord-298503-l60cdllh 402 10 for for IN cord-298503-l60cdllh 402 11 Rab Rab NNP cord-298503-l60cdllh 402 12 family family NN cord-298503-l60cdllh 402 13 G g NN cord-298503-l60cdllh 402 14 proteins protein NNS cord-298503-l60cdllh 403 1 An an DT cord-298503-l60cdllh 403 2 integral integral JJ cord-298503-l60cdllh 403 3 membrane membrane NN cord-298503-l60cdllh 403 4 component component NN cord-298503-l60cdllh 403 5 of of IN cord-298503-l60cdllh 403 6 coatomer coatomer JJ cord-298503-l60cdllh 403 7 - - HYPH cord-298503-l60cdllh 403 8 coated coat VBN cord-298503-l60cdllh 403 9 transport transport NN cord-298503-l60cdllh 403 10 vesicles vesicle NNS cord-298503-l60cdllh 403 11 defines define VBZ cord-298503-l60cdllh 403 12 a a DT cord-298503-l60cdllh 403 13 family family NN cord-298503-l60cdllh 403 14 of of IN cord-298503-l60cdllh 403 15 proteins protein NNS cord-298503-l60cdllh 403 16 involved involve VBN cord-298503-l60cdllh 403 17 in in IN cord-298503-l60cdllh 403 18 budding bud VBG cord-298503-l60cdllh 403 19 A a DT cord-298503-l60cdllh 403 20 role role NN cord-298503-l60cdllh 403 21 for for IN cord-298503-l60cdllh 403 22 kinesin-2 kinesin-2 NNP cord-298503-l60cdllh 403 23 in in IN cord-298503-l60cdllh 403 24 COPI COPI NNP cord-298503-l60cdllh 403 25 - - HYPH cord-298503-l60cdllh 403 26 dependent dependent JJ cord-298503-l60cdllh 403 27 recycling recycling NN cord-298503-l60cdllh 403 28 between between IN cord-298503-l60cdllh 403 29 the the DT cord-298503-l60cdllh 403 30 ER ER NNP cord-298503-l60cdllh 403 31 and and CC cord-298503-l60cdllh 403 32 the the DT cord-298503-l60cdllh 403 33 Golgi Golgi NNP cord-298503-l60cdllh 403 34 complex complex JJ cord-298503-l60cdllh 403 35 COPI COPI NNP cord-298503-l60cdllh 403 36 - - HYPH cord-298503-l60cdllh 403 37 coated coat VBN cord-298503-l60cdllh 403 38 ER er NN cord-298503-l60cdllh 403 39 - - HYPH cord-298503-l60cdllh 403 40 to to IN cord-298503-l60cdllh 403 41 - - HYPH cord-298503-l60cdllh 403 42 Golgi golgi NN cord-298503-l60cdllh 403 43 transport transport NN cord-298503-l60cdllh 403 44 complexes complex NNS cord-298503-l60cdllh 403 45 segregate segregate VBP cord-298503-l60cdllh 403 46 from from IN cord-298503-l60cdllh 403 47 COPII COPII NNP cord-298503-l60cdllh 403 48 in in IN cord-298503-l60cdllh 403 49 close close JJ cord-298503-l60cdllh 403 50 proximity proximity NN cord-298503-l60cdllh 403 51 to to IN cord-298503-l60cdllh 403 52 ER ER NNP cord-298503-l60cdllh 403 53 exit exit NN cord-298503-l60cdllh 403 54 sites site NNS cord-298503-l60cdllh 403 55 Illuminating illuminate VBG cord-298503-l60cdllh 403 56 the the DT cord-298503-l60cdllh 403 57 secretory secretory JJ cord-298503-l60cdllh 403 58 pathway pathway NN cord-298503-l60cdllh 403 59 : : : cord-298503-l60cdllh 403 60 When when WRB cord-298503-l60cdllh 403 61 do do VBP cord-298503-l60cdllh 403 62 we -PRON- PRP cord-298503-l60cdllh 403 63 need need VB cord-298503-l60cdllh 403 64 vesicles vesicle NNS cord-298503-l60cdllh 403 65 Imaging Imaging NNP cord-298503-l60cdllh 403 66 of of IN cord-298503-l60cdllh 403 67 procollagen procollagen NNP cord-298503-l60cdllh 403 68 transport transport NN cord-298503-l60cdllh 403 69 reveals reveal VBZ cord-298503-l60cdllh 403 70 COPIdependent COPIdependent NNP cord-298503-l60cdllh 403 71 cargo cargo NN cord-298503-l60cdllh 403 72 sorting sort VBG cord-298503-l60cdllh 403 73 during during IN cord-298503-l60cdllh 403 74 ER ER NNP cord-298503-l60cdllh 403 75 - - HYPH cord-298503-l60cdllh 403 76 to to IN cord-298503-l60cdllh 403 77 - - HYPH cord-298503-l60cdllh 403 78 Golgi golgi NN cord-298503-l60cdllh 403 79 transport transport NN cord-298503-l60cdllh 403 80 in in IN cord-298503-l60cdllh 403 81 mammalian mammalian JJ cord-298503-l60cdllh 403 82 cells cell NNS cord-298503-l60cdllh 403 83 Anterograde anterograde JJ cord-298503-l60cdllh 403 84 and and CC cord-298503-l60cdllh 403 85 retrograde retrograde JJ cord-298503-l60cdllh 403 86 traffic traffic NN cord-298503-l60cdllh 403 87 between between IN cord-298503-l60cdllh 403 88 the the DT cord-298503-l60cdllh 403 89 rough rough JJ cord-298503-l60cdllh 403 90 endoplasmic endoplasmic NN cord-298503-l60cdllh 403 91 reticulum reticulum NN cord-298503-l60cdllh 403 92 and and CC cord-298503-l60cdllh 403 93 the the DT cord-298503-l60cdllh 403 94 Golgi Golgi NNP cord-298503-l60cdllh 403 95 complex complex NN cord-298503-l60cdllh 403 96 Recycling recycling NN cord-298503-l60cdllh 403 97 of of IN cord-298503-l60cdllh 403 98 Golgi Golgi NNP cord-298503-l60cdllh 403 99 - - HYPH cord-298503-l60cdllh 403 100 resident resident JJ cord-298503-l60cdllh 403 101 glycosyltransferases glycosyltransferase NNS cord-298503-l60cdllh 403 102 through through IN cord-298503-l60cdllh 403 103 the the DT cord-298503-l60cdllh 403 104 ER ER NNP cord-298503-l60cdllh 403 105 reveals reveal VBZ cord-298503-l60cdllh 403 106 a a DT cord-298503-l60cdllh 403 107 novel novel JJ cord-298503-l60cdllh 403 108 pathway pathway NN cord-298503-l60cdllh 403 109 and and CC cord-298503-l60cdllh 403 110 provides provide VBZ cord-298503-l60cdllh 403 111 an an DT cord-298503-l60cdllh 403 112 explanation explanation NN cord-298503-l60cdllh 403 113 for for IN cord-298503-l60cdllh 403 114 nocodazole nocodazole NN cord-298503-l60cdllh 403 115 - - HYPH cord-298503-l60cdllh 403 116 induced induce VBN cord-298503-l60cdllh 403 117 Golgi Golgi NNP cord-298503-l60cdllh 403 118 scattering scatter VBG cord-298503-l60cdllh 403 119 The the DT cord-298503-l60cdllh 403 120 p24 p24 NN cord-298503-l60cdllh 403 121 family family NN cord-298503-l60cdllh 403 122 and and CC cord-298503-l60cdllh 403 123 selective selective JJ cord-298503-l60cdllh 403 124 transport transport NN cord-298503-l60cdllh 403 125 processes process NNS cord-298503-l60cdllh 403 126 at at IN cord-298503-l60cdllh 403 127 the the DT cord-298503-l60cdllh 403 128 ER ER NNP cord-298503-l60cdllh 403 129 - - HYPH cord-298503-l60cdllh 403 130 Golgi Golgi NNP cord-298503-l60cdllh 403 131 interface interface NN cord-298503-l60cdllh 403 132 PKCδ PKCδ NNS cord-298503-l60cdllh 403 133 and and CC cord-298503-l60cdllh 403 134 ε ε NNP cord-298503-l60cdllh 403 135 regulate regulate VB cord-298503-l60cdllh 403 136 the the DT cord-298503-l60cdllh 403 137 morphological morphological JJ cord-298503-l60cdllh 403 138 integrity integrity NN cord-298503-l60cdllh 403 139 of of IN cord-298503-l60cdllh 403 140 the the DT cord-298503-l60cdllh 403 141 ER ER NNP cord-298503-l60cdllh 403 142 - - HYPH cord-298503-l60cdllh 403 143 Golgi Golgi NNP cord-298503-l60cdllh 403 144 intermediate intermediate JJ cord-298503-l60cdllh 403 145 compartment compartment NN cord-298503-l60cdllh 403 146 ( ( -LRB- cord-298503-l60cdllh 403 147 ERGIC ERGIC NNP cord-298503-l60cdllh 403 148 ) ) -RRB- cord-298503-l60cdllh 403 149 but but CC cord-298503-l60cdllh 403 150 not not RB cord-298503-l60cdllh 403 151 the the DT cord-298503-l60cdllh 403 152 anterograde anterograde JJ cord-298503-l60cdllh 403 153 and and CC cord-298503-l60cdllh 403 154 retrograde retrograde JJ cord-298503-l60cdllh 403 155 transports transport NNS cord-298503-l60cdllh 403 156 via via IN cord-298503-l60cdllh 403 157 the the DT cord-298503-l60cdllh 403 158 Golgi Golgi NNP cord-298503-l60cdllh 403 159 apparatus apparatus NN cord-298503-l60cdllh 403 160 Role role NN cord-298503-l60cdllh 403 161 of of IN cord-298503-l60cdllh 403 162 vesicle vesicle NN cord-298503-l60cdllh 403 163 tethering tethering NN cord-298503-l60cdllh 403 164 factors factor NNS cord-298503-l60cdllh 403 165 in in IN cord-298503-l60cdllh 403 166 ER ER NNP cord-298503-l60cdllh 403 167 - - HYPH cord-298503-l60cdllh 403 168 Golgi golgi NN cord-298503-l60cdllh 403 169 membrane membrane NN cord-298503-l60cdllh 403 170 traffic traffic NN cord-298503-l60cdllh 403 171 Dissecting dissect VBG cord-298503-l60cdllh 403 172 the the DT cord-298503-l60cdllh 403 173 role role NN cord-298503-l60cdllh 403 174 of of IN cord-298503-l60cdllh 403 175 the the DT cord-298503-l60cdllh 403 176 ARF ARF NNP cord-298503-l60cdllh 403 177 guanine guanine NN cord-298503-l60cdllh 403 178 nucleotide nucleotide JJ cord-298503-l60cdllh 403 179 exchange exchange NN cord-298503-l60cdllh 403 180 factor factor NN cord-298503-l60cdllh 403 181 GBF1 GBF1 NNP cord-298503-l60cdllh 403 182 in in IN cord-298503-l60cdllh 403 183 Golgi Golgi NNP cord-298503-l60cdllh 403 184 biogenesis biogenesis NN cord-298503-l60cdllh 403 185 and and CC cord-298503-l60cdllh 403 186 protein protein NN cord-298503-l60cdllh 403 187 trafficking trafficking NN cord-298503-l60cdllh 403 188 Segregation Segregation NNP cord-298503-l60cdllh 403 189 of of IN cord-298503-l60cdllh 403 190 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 403 191 and and CC cord-298503-l60cdllh 403 192 the the DT cord-298503-l60cdllh 403 193 mammalian mammalian JJ cord-298503-l60cdllh 403 194 KDEL KDEL NNP cord-298503-l60cdllh 403 195 - - HYPH cord-298503-l60cdllh 403 196 receptor receptor NN cord-298503-l60cdllh 403 197 upon upon IN cord-298503-l60cdllh 403 198 exit exit NN cord-298503-l60cdllh 403 199 from from IN cord-298503-l60cdllh 403 200 the the DT cord-298503-l60cdllh 403 201 15 15 CD cord-298503-l60cdllh 403 202 1C 1C NNP cord-298503-l60cdllh 403 203 compartment compartment NNP cord-298503-l60cdllh 403 204 Differential Differential NNP cord-298503-l60cdllh 403 205 response response NN cord-298503-l60cdllh 403 206 of of IN cord-298503-l60cdllh 403 207 resident resident JJ cord-298503-l60cdllh 403 208 proteins protein NNS cord-298503-l60cdllh 403 209 and and CC cord-298503-l60cdllh 403 210 cycling cycling NN cord-298503-l60cdllh 403 211 proteins protein NNS cord-298503-l60cdllh 403 212 of of IN cord-298503-l60cdllh 403 213 the the DT cord-298503-l60cdllh 403 214 Golgi Golgi NNP cord-298503-l60cdllh 403 215 to to IN cord-298503-l60cdllh 403 216 brefeldin brefeldin NNP cord-298503-l60cdllh 404 1 A a DT cord-298503-l60cdllh 404 2 COPII COPII NNP cord-298503-l60cdllh 404 3 and and CC cord-298503-l60cdllh 404 4 exit exit NN cord-298503-l60cdllh 404 5 from from IN cord-298503-l60cdllh 404 6 the the DT cord-298503-l60cdllh 404 7 endoplasmic endoplasmic NN cord-298503-l60cdllh 404 8 reticulum reticulum NN cord-298503-l60cdllh 404 9 Molecular Molecular NNP cord-298503-l60cdllh 404 10 cloning cloning NN cord-298503-l60cdllh 404 11 , , , cord-298503-l60cdllh 404 12 characterization characterization NN cord-298503-l60cdllh 404 13 , , , cord-298503-l60cdllh 404 14 subcellular subcellular JJ cord-298503-l60cdllh 404 15 localization localization NN cord-298503-l60cdllh 404 16 and and CC cord-298503-l60cdllh 404 17 dynamics dynamic NNS cord-298503-l60cdllh 404 18 of of IN cord-298503-l60cdllh 404 19 p23 p23 CD cord-298503-l60cdllh 404 20 , , , cord-298503-l60cdllh 404 21 the the DT cord-298503-l60cdllh 404 22 mammalian mammalian JJ cord-298503-l60cdllh 404 23 KDEL KDEL NNP cord-298503-l60cdllh 404 24 receptor receptor NN cord-298503-l60cdllh 404 25 A a DT cord-298503-l60cdllh 404 26 Rab2 rab2 JJ cord-298503-l60cdllh 404 27 mutant mutant NN cord-298503-l60cdllh 404 28 with with IN cord-298503-l60cdllh 404 29 impaired impaired JJ cord-298503-l60cdllh 404 30 GTPase GTPase NNP cord-298503-l60cdllh 404 31 activity activity NN cord-298503-l60cdllh 404 32 stimulates stimulate VBZ cord-298503-l60cdllh 404 33 vesicle vesicle NN cord-298503-l60cdllh 404 34 formation formation NN cord-298503-l60cdllh 404 35 from from IN cord-298503-l60cdllh 404 36 pre pre JJ cord-298503-l60cdllh 404 37 - - JJ cord-298503-l60cdllh 404 38 Golgi Golgi NNP cord-298503-l60cdllh 404 39 intermediates intermediate NNS cord-298503-l60cdllh 404 40 Src Src NNP cord-298503-l60cdllh 404 41 - - HYPH cord-298503-l60cdllh 404 42 dependent dependent JJ cord-298503-l60cdllh 404 43 atypical atypical JJ cord-298503-l60cdllh 404 44 protein protein NN cord-298503-l60cdllh 404 45 kinase kinase NN cord-298503-l60cdllh 404 46 C C NNP cord-298503-l60cdllh 404 47 iota iota NN cord-298503-l60cdllh 404 48 / / SYM cord-298503-l60cdllh 404 49 lambda lambda NN cord-298503-l60cdllh 404 50 ( ( -LRB- cord-298503-l60cdllh 404 51 aPKCiota aPKCiota NNP cord-298503-l60cdllh 404 52 / / SYM cord-298503-l60cdllh 404 53 lambda lambda NN cord-298503-l60cdllh 404 54 ) ) -RRB- cord-298503-l60cdllh 404 55 tyrosine tyrosine NN cord-298503-l60cdllh 404 56 phosphorylation phosphorylation NN cord-298503-l60cdllh 404 57 is be VBZ cord-298503-l60cdllh 404 58 required require VBN cord-298503-l60cdllh 404 59 for for IN cord-298503-l60cdllh 404 60 aPKCiota aPKCiota NNP cord-298503-l60cdllh 404 61 / / SYM cord-298503-l60cdllh 404 62 lambda lambda NNP cord-298503-l60cdllh 404 63 association association NN cord-298503-l60cdllh 404 64 with with IN cord-298503-l60cdllh 404 65 Rab2 Rab2 NNP cord-298503-l60cdllh 404 66 and and CC cord-298503-l60cdllh 404 67 glyceraldehyde-3-phosphate glyceraldehyde-3-phosphate NNP cord-298503-l60cdllh 404 68 dehydrogenase dehydrogenase NN cord-298503-l60cdllh 404 69 on on IN cord-298503-l60cdllh 404 70 pre pre JJ cord-298503-l60cdllh 404 71 - - JJ cord-298503-l60cdllh 404 72 Golgi golgi JJ cord-298503-l60cdllh 404 73 intermediates intermediate NNS cord-298503-l60cdllh 405 1 Rab2 Rab2 NNP cord-298503-l60cdllh 405 2 utilizes utilize VBZ cord-298503-l60cdllh 405 3 glyceraldehyde-3-phosphate glyceraldehyde-3-phosphate JJ cord-298503-l60cdllh 405 4 dehydrogenase dehydrogenase NN cord-298503-l60cdllh 405 5 and and CC cord-298503-l60cdllh 405 6 protein protein NN cord-298503-l60cdllh 405 7 kinase kinase NN cord-298503-l60cdllh 405 8 C{iota C{iota NNP cord-298503-l60cdllh 405 9 } } -RRB- cord-298503-l60cdllh 405 10 to to TO cord-298503-l60cdllh 405 11 associate associate VB cord-298503-l60cdllh 405 12 with with IN cord-298503-l60cdllh 405 13 microtubules microtubule NNS cord-298503-l60cdllh 405 14 and and CC cord-298503-l60cdllh 405 15 to to TO cord-298503-l60cdllh 405 16 recruit recruit VB cord-298503-l60cdllh 405 17 dynein dynein JJ cord-298503-l60cdllh 405 18 GTPbinding gtpbinding NN cord-298503-l60cdllh 405 19 mutants mutant NNS cord-298503-l60cdllh 405 20 of of IN cord-298503-l60cdllh 405 21 Rab1 Rab1 NNP cord-298503-l60cdllh 405 22 and and CC cord-298503-l60cdllh 405 23 Rab2 Rab2 NNP cord-298503-l60cdllh 406 1 are be VBP cord-298503-l60cdllh 406 2 potent potent JJ cord-298503-l60cdllh 406 3 inhibitors inhibitor NNS cord-298503-l60cdllh 406 4 of of IN cord-298503-l60cdllh 406 5 vesicular vesicular JJ cord-298503-l60cdllh 406 6 transport transport NN cord-298503-l60cdllh 406 7 from from IN cord-298503-l60cdllh 406 8 the the DT cord-298503-l60cdllh 406 9 endoplasmic endoplasmic NN cord-298503-l60cdllh 406 10 reticulum reticulum NN cord-298503-l60cdllh 406 11 to to IN cord-298503-l60cdllh 406 12 the the DT cord-298503-l60cdllh 406 13 Golgi Golgi NNP cord-298503-l60cdllh 406 14 complex complex NN cord-298503-l60cdllh 406 15 p53/58 p53/58 NNP cord-298503-l60cdllh 406 16 binds bind VBZ cord-298503-l60cdllh 406 17 COPI COPI NNP cord-298503-l60cdllh 406 18 and and CC cord-298503-l60cdllh 406 19 is be VBZ cord-298503-l60cdllh 406 20 required require VBN cord-298503-l60cdllh 406 21 for for IN cord-298503-l60cdllh 406 22 selective selective JJ cord-298503-l60cdllh 406 23 transport transport NN cord-298503-l60cdllh 406 24 through through IN cord-298503-l60cdllh 406 25 the the DT cord-298503-l60cdllh 406 26 early early JJ cord-298503-l60cdllh 406 27 secretory secretory JJ cord-298503-l60cdllh 406 28 pathway pathway NN cord-298503-l60cdllh 406 29 Regulation regulation NN cord-298503-l60cdllh 406 30 of of IN cord-298503-l60cdllh 406 31 ER ER NNP cord-298503-l60cdllh 406 32 - - HYPH cord-298503-l60cdllh 406 33 Golgi Golgi NNP cord-298503-l60cdllh 406 34 intermediate intermediate JJ cord-298503-l60cdllh 406 35 compartment compartment NN cord-298503-l60cdllh 406 36 tubulation tubulation NN cord-298503-l60cdllh 406 37 and and CC cord-298503-l60cdllh 406 38 mobility mobility NN cord-298503-l60cdllh 406 39 by by IN cord-298503-l60cdllh 406 40 COPI COPI NNP cord-298503-l60cdllh 406 41 coats coat NNS cord-298503-l60cdllh 406 42 , , , cord-298503-l60cdllh 406 43 motor motor NN cord-298503-l60cdllh 406 44 proteins protein NNS cord-298503-l60cdllh 406 45 and and CC cord-298503-l60cdllh 406 46 microtubules microtubule VBZ cord-298503-l60cdllh 406 47 Replication replication NN cord-298503-l60cdllh 406 48 of of IN cord-298503-l60cdllh 406 49 coronavirus coronavirus NN cord-298503-l60cdllh 406 50 MHV mhv NN cord-298503-l60cdllh 406 51 - - HYPH cord-298503-l60cdllh 406 52 A59 A59 NNP cord-298503-l60cdllh 406 53 in in IN cord-298503-l60cdllh 406 54 saccells saccell NNS cord-298503-l60cdllh 406 55 : : : cord-298503-l60cdllh 407 1 Determination determination NN cord-298503-l60cdllh 407 2 of of IN cord-298503-l60cdllh 407 3 the the DT cord-298503-l60cdllh 407 4 first first JJ cord-298503-l60cdllh 407 5 site site NN cord-298503-l60cdllh 407 6 of of IN cord-298503-l60cdllh 407 7 budding budding NN cord-298503-l60cdllh 407 8 of of IN cord-298503-l60cdllh 407 9 progeny progeny JJ cord-298503-l60cdllh 407 10 virions virion NNS cord-298503-l60cdllh 407 11 Site site NN cord-298503-l60cdllh 407 12 of of IN cord-298503-l60cdllh 407 13 addition addition NN cord-298503-l60cdllh 407 14 of of IN cord-298503-l60cdllh 407 15 N n NN cord-298503-l60cdllh 407 16 - - HYPH cord-298503-l60cdllh 407 17 acetyl acetyl NN cord-298503-l60cdllh 407 18 - - HYPH cord-298503-l60cdllh 407 19 galactosamine galactosamine NN cord-298503-l60cdllh 407 20 to to IN cord-298503-l60cdllh 407 21 the the DT cord-298503-l60cdllh 407 22 E1 e1 NN cord-298503-l60cdllh 407 23 glycoprotein glycoprotein NN cord-298503-l60cdllh 407 24 of of IN cord-298503-l60cdllh 407 25 mouse mouse NN cord-298503-l60cdllh 407 26 hepatitis hepatitis NN cord-298503-l60cdllh 407 27 virus virus NN cord-298503-l60cdllh 407 28 - - : cord-298503-l60cdllh 407 29 A59 A59 NNP cord-298503-l60cdllh 407 30 Secretory Secretory NNP cord-298503-l60cdllh 407 31 traffic traffic NN cord-298503-l60cdllh 407 32 triggers trigger VBZ cord-298503-l60cdllh 407 33 the the DT cord-298503-l60cdllh 407 34 formation formation NN cord-298503-l60cdllh 407 35 of of IN cord-298503-l60cdllh 407 36 tubular tubular JJ cord-298503-l60cdllh 407 37 continuities continuity NNS cord-298503-l60cdllh 407 38 across across IN cord-298503-l60cdllh 407 39 Golgi Golgi NNP cord-298503-l60cdllh 407 40 subcompartments subcompartment NNS cord-298503-l60cdllh 408 1 The the DT cord-298503-l60cdllh 408 2 yeast yeast NN cord-298503-l60cdllh 409 1 Rab Rab NNP cord-298503-l60cdllh 409 2 GTPase GTPase NNP cord-298503-l60cdllh 409 3 Ypt1 Ypt1 NNP cord-298503-l60cdllh 409 4 modulates modulate VBZ cord-298503-l60cdllh 409 5 unfolded unfold VBN cord-298503-l60cdllh 409 6 protein protein NN cord-298503-l60cdllh 409 7 response response NN cord-298503-l60cdllh 409 8 dynamics dynamic NNS cord-298503-l60cdllh 409 9 by by IN cord-298503-l60cdllh 409 10 regulating regulate VBG cord-298503-l60cdllh 409 11 the the DT cord-298503-l60cdllh 409 12 stability stability NN cord-298503-l60cdllh 409 13 of of IN cord-298503-l60cdllh 409 14 HAC1 HAC1 NNP cord-298503-l60cdllh 409 15 RNA RNA NNP cord-298503-l60cdllh 409 16 Cholesterol Cholesterol NNP cord-298503-l60cdllh 409 17 and and CC cord-298503-l60cdllh 409 18 vesicular vesicular JJ cord-298503-l60cdllh 409 19 stomatitis stomatitis NN cord-298503-l60cdllh 409 20 virus virus NN cord-298503-l60cdllh 409 21 G g NN cord-298503-l60cdllh 409 22 protein protein NN cord-298503-l60cdllh 410 1 take take VB cord-298503-l60cdllh 410 2 separate separate JJ cord-298503-l60cdllh 410 3 routes route NNS cord-298503-l60cdllh 410 4 from from IN cord-298503-l60cdllh 410 5 the the DT cord-298503-l60cdllh 410 6 endoplasmic endoplasmic NN cord-298503-l60cdllh 410 7 reticulum reticulum NN cord-298503-l60cdllh 410 8 to to IN cord-298503-l60cdllh 410 9 the the DT cord-298503-l60cdllh 410 10 plasma plasma NN cord-298503-l60cdllh 410 11 membrane membrane NN cord-298503-l60cdllh 411 1 A a DT cord-298503-l60cdllh 411 2 pH ph NN cord-298503-l60cdllh 411 3 - - HYPH cord-298503-l60cdllh 411 4 regulated regulated JJ cord-298503-l60cdllh 411 5 quality quality NN cord-298503-l60cdllh 411 6 control control NN cord-298503-l60cdllh 411 7 cycle cycle NN cord-298503-l60cdllh 411 8 for for IN cord-298503-l60cdllh 411 9 surveillance surveillance NN cord-298503-l60cdllh 411 10 of of IN cord-298503-l60cdllh 411 11 secretory secretory JJ cord-298503-l60cdllh 411 12 protein protein NN cord-298503-l60cdllh 411 13 assembly assembly NN cord-298503-l60cdllh 412 1 The the DT cord-298503-l60cdllh 412 2 crystal crystal JJ cord-298503-l60cdllh 412 3 structure structure NN cord-298503-l60cdllh 412 4 of of IN cord-298503-l60cdllh 412 5 the the DT cord-298503-l60cdllh 412 6 carbohydrate carbohydrate NN cord-298503-l60cdllh 412 7 - - HYPH cord-298503-l60cdllh 412 8 recognition recognition NN cord-298503-l60cdllh 412 9 domain domain NN cord-298503-l60cdllh 412 10 of of IN cord-298503-l60cdllh 412 11 the the DT cord-298503-l60cdllh 412 12 glycoprotein glycoprotein NN cord-298503-l60cdllh 412 13 sorting sort VBG cord-298503-l60cdllh 412 14 receptor receptor NN cord-298503-l60cdllh 412 15 p58 p58 NNP cord-298503-l60cdllh 412 16 / / SYM cord-298503-l60cdllh 412 17 ERGIC-53 ERGIC-53 NNP cord-298503-l60cdllh 412 18 reveals reveal VBZ cord-298503-l60cdllh 412 19 an an DT cord-298503-l60cdllh 412 20 unpredicted unpredicted JJ cord-298503-l60cdllh 412 21 metal metal NN cord-298503-l60cdllh 412 22 - - HYPH cord-298503-l60cdllh 412 23 binding bind VBG cord-298503-l60cdllh 412 24 site site NN cord-298503-l60cdllh 412 25 and and CC cord-298503-l60cdllh 412 26 conformational conformational JJ cord-298503-l60cdllh 412 27 changes change NNS cord-298503-l60cdllh 412 28 associated associate VBN cord-298503-l60cdllh 412 29 with with IN cord-298503-l60cdllh 412 30 calcium calcium NN cord-298503-l60cdllh 412 31 ion ion NN cord-298503-l60cdllh 412 32 binding bind VBG cord-298503-l60cdllh 412 33 Megavesicles Megavesicles NNP cord-298503-l60cdllh 412 34 implicated implicate VBN cord-298503-l60cdllh 412 35 in in IN cord-298503-l60cdllh 412 36 the the DT cord-298503-l60cdllh 412 37 rapid rapid JJ cord-298503-l60cdllh 412 38 transport transport NN cord-298503-l60cdllh 412 39 of of IN cord-298503-l60cdllh 412 40 intracisternal intracisternal JJ cord-298503-l60cdllh 412 41 aggregates aggregate NNS cord-298503-l60cdllh 412 42 across across IN cord-298503-l60cdllh 412 43 the the DT cord-298503-l60cdllh 412 44 Golgi Golgi NNP cord-298503-l60cdllh 412 45 stack stack VB cord-298503-l60cdllh 412 46 Isoform Isoform NNP cord-298503-l60cdllh 412 47 - - HYPH cord-298503-l60cdllh 412 48 selective selective JJ cord-298503-l60cdllh 412 49 effects effect NNS cord-298503-l60cdllh 412 50 of of IN cord-298503-l60cdllh 412 51 the the DT cord-298503-l60cdllh 412 52 depletion depletion NN cord-298503-l60cdllh 412 53 of of IN cord-298503-l60cdllh 412 54 ADP adp NN cord-298503-l60cdllh 412 55 - - HYPH cord-298503-l60cdllh 412 56 ribosylation ribosylation NN cord-298503-l60cdllh 412 57 factors factor NNS cord-298503-l60cdllh 412 58 1 1 CD cord-298503-l60cdllh 412 59 - - SYM cord-298503-l60cdllh 412 60 5 5 CD cord-298503-l60cdllh 412 61 on on IN cord-298503-l60cdllh 412 62 membrane membrane NN cord-298503-l60cdllh 412 63 traffic traffic NN cord-298503-l60cdllh 412 64 Regulation regulation NN cord-298503-l60cdllh 412 65 of of IN cord-298503-l60cdllh 412 66 Integrin Integrin NNP cord-298503-l60cdllh 412 67 β1 β1 NNP cord-298503-l60cdllh 412 68 recycling recycling NN cord-298503-l60cdllh 412 69 to to IN cord-298503-l60cdllh 412 70 lipid lipid NN cord-298503-l60cdllh 412 71 rafts raft NNS cord-298503-l60cdllh 412 72 by by IN cord-298503-l60cdllh 412 73 Rab1a Rab1a NNP cord-298503-l60cdllh 412 74 to to TO cord-298503-l60cdllh 412 75 promote promote VB cord-298503-l60cdllh 412 76 cell cell NN cord-298503-l60cdllh 412 77 migration migration NN cord-298503-l60cdllh 412 78 Maintenance maintenance NN cord-298503-l60cdllh 412 79 of of IN cord-298503-l60cdllh 412 80 Golgi Golgi NNP cord-298503-l60cdllh 412 81 structure structure NN cord-298503-l60cdllh 412 82 and and CC cord-298503-l60cdllh 412 83 function function NN cord-298503-l60cdllh 412 84 depends depend VBZ cord-298503-l60cdllh 412 85 on on IN cord-298503-l60cdllh 412 86 the the DT cord-298503-l60cdllh 412 87 integrity integrity NN cord-298503-l60cdllh 412 88 of of IN cord-298503-l60cdllh 412 89 ER ER NNP cord-298503-l60cdllh 412 90 export export NN cord-298503-l60cdllh 412 91 Signals signal NNS cord-298503-l60cdllh 412 92 and and CC cord-298503-l60cdllh 412 93 salvage salvage NN cord-298503-l60cdllh 412 94 sequences sequence NNS cord-298503-l60cdllh 412 95 pH ph NN cord-298503-l60cdllh 412 96 - - HYPH cord-298503-l60cdllh 412 97 dependent dependent JJ cord-298503-l60cdllh 412 98 binding binding NN cord-298503-l60cdllh 412 99 of of IN cord-298503-l60cdllh 412 100 KDEL KDEL NNP cord-298503-l60cdllh 412 101 to to IN cord-298503-l60cdllh 412 102 its -PRON- PRP$ cord-298503-l60cdllh 412 103 receptor receptor NN cord-298503-l60cdllh 412 104 in in IN cord-298503-l60cdllh 412 105 vitro vitro FW cord-298503-l60cdllh 413 1 α α NNP cord-298503-l60cdllh 413 2 - - HYPH cord-298503-l60cdllh 413 3 Synuclein Synuclein NNP cord-298503-l60cdllh 413 4 impairs impair VBZ cord-298503-l60cdllh 413 5 macroautophagy macroautophagy NNS cord-298503-l60cdllh 413 6 : : : cord-298503-l60cdllh 413 7 Implications implication NNS cord-298503-l60cdllh 413 8 for for IN cord-298503-l60cdllh 413 9 Parkinson Parkinson NNP cord-298503-l60cdllh 413 10 's 's POS cord-298503-l60cdllh 413 11 disease disease NN cord-298503-l60cdllh 413 12 Reconstitution Reconstitution NNP cord-298503-l60cdllh 413 13 of of IN cord-298503-l60cdllh 413 14 COPII COPII NNP cord-298503-l60cdllh 413 15 vesicle vesicle NN cord-298503-l60cdllh 413 16 fusion fusion NN cord-298503-l60cdllh 413 17 to to TO cord-298503-l60cdllh 413 18 generate generate VB cord-298503-l60cdllh 413 19 a a DT cord-298503-l60cdllh 413 20 pre pre JJ cord-298503-l60cdllh 413 21 - - JJ cord-298503-l60cdllh 413 22 Golgi golgi JJ cord-298503-l60cdllh 413 23 intermediate intermediate JJ cord-298503-l60cdllh 413 24 compartment compartment NN cord-298503-l60cdllh 413 25 Subunit Subunit NNP cord-298503-l60cdllh 413 26 structure structure NN cord-298503-l60cdllh 413 27 of of IN cord-298503-l60cdllh 413 28 a a DT cord-298503-l60cdllh 413 29 mammalian mammalian JJ cord-298503-l60cdllh 413 30 ER ER NNP cord-298503-l60cdllh 413 31 / / SYM cord-298503-l60cdllh 413 32 Golgi Golgi NNP cord-298503-l60cdllh 413 33 SNARE snare VB cord-298503-l60cdllh 413 34 complex complex JJ cord-298503-l60cdllh 414 1 The the DT cord-298503-l60cdllh 414 2 KDEL KDEL NNP cord-298503-l60cdllh 414 3 receptor receptor NN cord-298503-l60cdllh 414 4 mediates mediate VBZ cord-298503-l60cdllh 414 5 a a DT cord-298503-l60cdllh 414 6 retrieval retrieval NN cord-298503-l60cdllh 414 7 mechanism mechanism NN cord-298503-l60cdllh 414 8 that that WDT cord-298503-l60cdllh 414 9 contributes contribute VBZ cord-298503-l60cdllh 414 10 to to IN cord-298503-l60cdllh 414 11 quality quality NN cord-298503-l60cdllh 414 12 control control NN cord-298503-l60cdllh 414 13 at at IN cord-298503-l60cdllh 414 14 the the DT cord-298503-l60cdllh 414 15 endoplasmic endoplasmic NN cord-298503-l60cdllh 414 16 reticulum reticulum NN cord-298503-l60cdllh 415 1 The the DT cord-298503-l60cdllh 415 2 p58-positive p58-positive JJ cord-298503-l60cdllh 415 3 pre pre JJ cord-298503-l60cdllh 415 4 - - JJ cord-298503-l60cdllh 415 5 Golgi golgi JJ cord-298503-l60cdllh 415 6 intermediates intermediate NNS cord-298503-l60cdllh 415 7 consist consist VBP cord-298503-l60cdllh 415 8 of of IN cord-298503-l60cdllh 415 9 distinct distinct JJ cord-298503-l60cdllh 415 10 subpopulations subpopulation NNS cord-298503-l60cdllh 415 11 of of IN cord-298503-l60cdllh 415 12 particles particle NNS cord-298503-l60cdllh 415 13 that that WDT cord-298503-l60cdllh 415 14 show show VBP cord-298503-l60cdllh 415 15 differential differential NN cord-298503-l60cdllh 415 16 binding binding NN cord-298503-l60cdllh 415 17 of of IN cord-298503-l60cdllh 415 18 COPI COPI NNP cord-298503-l60cdllh 415 19 and and CC cord-298503-l60cdllh 415 20 COPII COPII NNP cord-298503-l60cdllh 415 21 coats coat NNS cord-298503-l60cdllh 415 22 and and CC cord-298503-l60cdllh 415 23 contain contain VBP cord-298503-l60cdllh 415 24 vacuolar vacuolar JJ cord-298503-l60cdllh 415 25 H h NN cord-298503-l60cdllh 415 26 þ þ NN cord-298503-l60cdllh 416 1 -ATPase -atpase IN cord-298503-l60cdllh 416 2 Colocalization Colocalization NNP cord-298503-l60cdllh 416 3 of of IN cord-298503-l60cdllh 416 4 Ca Ca NNP cord-298503-l60cdllh 416 5 2 2 CD cord-298503-l60cdllh 416 6 þ þ NN cord-298503-l60cdllh 417 1 -ATPase -ATPase NNP cord-298503-l60cdllh 418 1 and and CC cord-298503-l60cdllh 418 2 GRP94 GRP94 NNP cord-298503-l60cdllh 418 3 with with IN cord-298503-l60cdllh 418 4 p58 p58 NNP cord-298503-l60cdllh 418 5 and and CC cord-298503-l60cdllh 418 6 the the DT cord-298503-l60cdllh 418 7 effects effect NNS cord-298503-l60cdllh 418 8 of of IN cord-298503-l60cdllh 418 9 thapsigargin thapsigargin NNP cord-298503-l60cdllh 418 10 on on IN cord-298503-l60cdllh 418 11 protein protein NN cord-298503-l60cdllh 418 12 recycling recycling NN cord-298503-l60cdllh 418 13 suggest suggest VBP cord-298503-l60cdllh 418 14 the the DT cord-298503-l60cdllh 418 15 participation participation NN cord-298503-l60cdllh 418 16 of of IN cord-298503-l60cdllh 418 17 the the DT cord-298503-l60cdllh 418 18 pre pre JJ cord-298503-l60cdllh 418 19 - - JJ cord-298503-l60cdllh 418 20 Golgi Golgi NNP cord-298503-l60cdllh 418 21 intermediate intermediate JJ cord-298503-l60cdllh 418 22 compartment compartment NN cord-298503-l60cdllh 418 23 in in IN cord-298503-l60cdllh 418 24 intracellular intracellular JJ cord-298503-l60cdllh 419 1 Ca ca NN cord-298503-l60cdllh 419 2 2 2 CD cord-298503-l60cdllh 419 3 þ þ CD cord-298503-l60cdllh 419 4 -storage -storage HYPH cord-298503-l60cdllh 419 5 Non non JJ cord-298503-l60cdllh 419 6 - - JJ cord-298503-l60cdllh 419 7 conventional conventional JJ cord-298503-l60cdllh 419 8 trafficking trafficking NN cord-298503-l60cdllh 419 9 of of IN cord-298503-l60cdllh 419 10 the the DT cord-298503-l60cdllh 419 11 cystic cystic JJ cord-298503-l60cdllh 419 12 fibrosis fibrosis NN cord-298503-l60cdllh 419 13 transmembrane transmembrane NNP cord-298503-l60cdllh 419 14 conductance conductance NN cord-298503-l60cdllh 419 15 regulator regulator NN cord-298503-l60cdllh 419 16 through through IN cord-298503-l60cdllh 419 17 the the DT cord-298503-l60cdllh 419 18 early early JJ cord-298503-l60cdllh 419 19 secretory secretory JJ cord-298503-l60cdllh 419 20 pathway pathway NN cord-298503-l60cdllh 419 21 mBet3p mBet3p NNP cord-298503-l60cdllh 419 22 is be VBZ cord-298503-l60cdllh 419 23 required require VBN cord-298503-l60cdllh 419 24 for for IN cord-298503-l60cdllh 419 25 homotypic homotypic JJ cord-298503-l60cdllh 419 26 COPII COPII NNP cord-298503-l60cdllh 419 27 vesicle vesicle NN cord-298503-l60cdllh 419 28 tethering tethering NN cord-298503-l60cdllh 419 29 in in IN cord-298503-l60cdllh 419 30 mammalian mammalian JJ cord-298503-l60cdllh 419 31 cells cell NNS cord-298503-l60cdllh 419 32 Ykt6 Ykt6 NNP cord-298503-l60cdllh 419 33 forms form VBZ cord-298503-l60cdllh 419 34 a a DT cord-298503-l60cdllh 419 35 SNARE snare NN cord-298503-l60cdllh 419 36 complex complex NN cord-298503-l60cdllh 419 37 with with IN cord-298503-l60cdllh 419 38 syntaxin syntaxin NNP cord-298503-l60cdllh 419 39 5 5 CD cord-298503-l60cdllh 419 40 , , , cord-298503-l60cdllh 419 41 GS28 GS28 NNP cord-298503-l60cdllh 419 42 , , , cord-298503-l60cdllh 419 43 and and CC cord-298503-l60cdllh 419 44 Bet1 Bet1 NNP cord-298503-l60cdllh 419 45 and and CC cord-298503-l60cdllh 419 46 participates participate VBZ cord-298503-l60cdllh 419 47 in in IN cord-298503-l60cdllh 419 48 a a DT cord-298503-l60cdllh 419 49 late late JJ cord-298503-l60cdllh 419 50 stage stage NN cord-298503-l60cdllh 419 51 in in IN cord-298503-l60cdllh 419 52 endoplasmic endoplasmic NN cord-298503-l60cdllh 419 53 reticulum reticulum NN cord-298503-l60cdllh 419 54 - - : cord-298503-l60cdllh 419 55 Golgi golgi NN cord-298503-l60cdllh 419 56 transport transport NN cord-298503-l60cdllh 420 1 The the DT cord-298503-l60cdllh 420 2 mammalian mammalian JJ cord-298503-l60cdllh 420 3 protein protein NN cord-298503-l60cdllh 420 4 ( ( -LRB- cord-298503-l60cdllh 420 5 rbet1 rbet1 NN cord-298503-l60cdllh 420 6 ) ) -RRB- cord-298503-l60cdllh 420 7 homologous homologous JJ cord-298503-l60cdllh 420 8 to to IN cord-298503-l60cdllh 420 9 yeast yeast NN cord-298503-l60cdllh 420 10 Bet1p bet1p WDT cord-298503-l60cdllh 420 11 is be VBZ cord-298503-l60cdllh 420 12 primarily primarily RB cord-298503-l60cdllh 420 13 associated associate VBN cord-298503-l60cdllh 420 14 with with IN cord-298503-l60cdllh 420 15 the the DT cord-298503-l60cdllh 420 16 pre pre JJ cord-298503-l60cdllh 420 17 - - JJ cord-298503-l60cdllh 420 18 Golgi Golgi NNP cord-298503-l60cdllh 420 19 intermediate intermediate JJ cord-298503-l60cdllh 420 20 compartment compartment NN cord-298503-l60cdllh 420 21 and and CC cord-298503-l60cdllh 420 22 is be VBZ cord-298503-l60cdllh 420 23 involved involve VBN cord-298503-l60cdllh 420 24 in in IN cord-298503-l60cdllh 420 25 vesicular vesicular JJ cord-298503-l60cdllh 420 26 transport transport NN cord-298503-l60cdllh 420 27 from from IN cord-298503-l60cdllh 420 28 the the DT cord-298503-l60cdllh 420 29 endoplasmic endoplasmic NN cord-298503-l60cdllh 420 30 reticulum reticulum NN cord-298503-l60cdllh 420 31 to to IN cord-298503-l60cdllh 420 32 the the DT cord-298503-l60cdllh 420 33 Golgi Golgi NNP cord-298503-l60cdllh 420 34 apparatus apparatus NN cord-298503-l60cdllh 420 35 Morphological morphological JJ cord-298503-l60cdllh 420 36 and and CC cord-298503-l60cdllh 420 37 functional functional JJ cord-298503-l60cdllh 420 38 association association NN cord-298503-l60cdllh 420 39 of of IN cord-298503-l60cdllh 420 40 Sec22b Sec22b NNP cord-298503-l60cdllh 420 41 / / SYM cord-298503-l60cdllh 420 42 ERS-24 ERS-24 NNP cord-298503-l60cdllh 420 43 with with IN cord-298503-l60cdllh 420 44 the the DT cord-298503-l60cdllh 420 45 pre pre JJ cord-298503-l60cdllh 420 46 - - JJ cord-298503-l60cdllh 420 47 Golgi golgi JJ cord-298503-l60cdllh 420 48 intermediate intermediate JJ cord-298503-l60cdllh 420 49 compartment compartment NN cord-298503-l60cdllh 420 50 GBF1 GBF1 NNP cord-298503-l60cdllh 420 51 , , , cord-298503-l60cdllh 420 52 a a DT cord-298503-l60cdllh 420 53 cis cis NNP cord-298503-l60cdllh 420 54 - - HYPH cord-298503-l60cdllh 420 55 Golgi Golgi NNP cord-298503-l60cdllh 420 56 and and CC cord-298503-l60cdllh 420 57 VTCs vtcs NN cord-298503-l60cdllh 420 58 - - HYPH cord-298503-l60cdllh 420 59 localized localize VBN cord-298503-l60cdllh 420 60 ARF arf NN cord-298503-l60cdllh 420 61 - - HYPH cord-298503-l60cdllh 420 62 GEF GEF NNP cord-298503-l60cdllh 420 63 , , , cord-298503-l60cdllh 420 64 is be VBZ cord-298503-l60cdllh 420 65 implicated implicate VBN cord-298503-l60cdllh 420 66 in in IN cord-298503-l60cdllh 420 67 ER ER NNP cord-298503-l60cdllh 420 68 - - HYPH cord-298503-l60cdllh 420 69 to to IN cord-298503-l60cdllh 420 70 - - HYPH cord-298503-l60cdllh 420 71 Golgi golgi NN cord-298503-l60cdllh 420 72 protein protein NN cord-298503-l60cdllh 420 73 traffic traffic NN cord-298503-l60cdllh 420 74 Structural structural JJ cord-298503-l60cdllh 420 75 characterization characterization NN cord-298503-l60cdllh 420 76 of of IN cord-298503-l60cdllh 420 77 carbohydrate carbohydrate NN cord-298503-l60cdllh 420 78 binding bind VBG cord-298503-l60cdllh 420 79 by by IN cord-298503-l60cdllh 420 80 LMAN1 lman1 WDT cord-298503-l60cdllh 420 81 protein protein NN cord-298503-l60cdllh 421 1 provides provide VBZ cord-298503-l60cdllh 421 2 new new JJ cord-298503-l60cdllh 421 3 insight insight NN cord-298503-l60cdllh 421 4 into into IN cord-298503-l60cdllh 421 5 the the DT cord-298503-l60cdllh 421 6 endoplasmic endoplasmic NN cord-298503-l60cdllh 421 7 reticulum reticulum NN cord-298503-l60cdllh 421 8 export export NN cord-298503-l60cdllh 421 9 of of IN cord-298503-l60cdllh 421 10 factors factor NNS cord-298503-l60cdllh 421 11 V v NN cord-298503-l60cdllh 421 12 ( ( -LRB- cord-298503-l60cdllh 421 13 FV FV NNP cord-298503-l60cdllh 421 14 ) ) -RRB- cord-298503-l60cdllh 421 15 and and CC cord-298503-l60cdllh 421 16 VIII VIII NNP cord-298503-l60cdllh 421 17 ( ( -LRB- cord-298503-l60cdllh 421 18 FVIII FVIII NNP cord-298503-l60cdllh 421 19 ) ) -RRB- cord-298503-l60cdllh 422 1 Combined combined JJ cord-298503-l60cdllh 422 2 deficiency deficiency NN cord-298503-l60cdllh 422 3 of of IN cord-298503-l60cdllh 422 4 coagulation coagulation NN cord-298503-l60cdllh 422 5 factors factor NNS cord-298503-l60cdllh 422 6 V v NN cord-298503-l60cdllh 422 7 and and CC cord-298503-l60cdllh 422 8 VIII VIII NNP cord-298503-l60cdllh 422 9 : : : cord-298503-l60cdllh 423 1 An an DT cord-298503-l60cdllh 423 2 update update NN cord-298503-l60cdllh 423 3 Autophagosome Autophagosome NNP cord-298503-l60cdllh 423 4 formation formation NN cord-298503-l60cdllh 423 5 depends depend VBZ cord-298503-l60cdllh 423 6 on on IN cord-298503-l60cdllh 423 7 the the DT cord-298503-l60cdllh 423 8 small small JJ cord-298503-l60cdllh 423 9 GTPase GTPase NNP cord-298503-l60cdllh 423 10 Rab1 Rab1 NNP cord-298503-l60cdllh 423 11 and and CC cord-298503-l60cdllh 423 12 functional functional JJ cord-298503-l60cdllh 423 13 ER ER NNP cord-298503-l60cdllh 423 14 exit exit NN cord-298503-l60cdllh 423 15 sites site NNS cord-298503-l60cdllh 423 16 Immunolocalization immunolocalization NN cord-298503-l60cdllh 423 17 of of IN cord-298503-l60cdllh 423 18 UDP udp NN cord-298503-l60cdllh 423 19 - - HYPH cord-298503-l60cdllh 423 20 glucose glucose NN cord-298503-l60cdllh 424 1 : : : cord-298503-l60cdllh 424 2 glycoprotein glycoprotein NNP cord-298503-l60cdllh 424 3 glucosyltransferase glucosyltransferase NNP cord-298503-l60cdllh 424 4 indicates indicate VBZ cord-298503-l60cdllh 424 5 involvement involvement NN cord-298503-l60cdllh 424 6 of of IN cord-298503-l60cdllh 424 7 pre pre JJ cord-298503-l60cdllh 424 8 - - JJ cord-298503-l60cdllh 424 9 Golgi golgi JJ cord-298503-l60cdllh 424 10 intermediates intermediate NNS cord-298503-l60cdllh 424 11 in in IN cord-298503-l60cdllh 424 12 protein protein NN cord-298503-l60cdllh 424 13 quality quality NN cord-298503-l60cdllh 424 14 control control NN cord-298503-l60cdllh 425 1 Misfolded Misfolded NNP cord-298503-l60cdllh 425 2 proinsulin proinsulin NNP cord-298503-l60cdllh 425 3 accumulates accumulate VBZ cord-298503-l60cdllh 425 4 in in IN cord-298503-l60cdllh 425 5 expanded expand VBN cord-298503-l60cdllh 425 6 pre pre JJ cord-298503-l60cdllh 425 7 - - JJ cord-298503-l60cdllh 425 8 Golgi golgi JJ cord-298503-l60cdllh 425 9 intermediates intermediate NNS cord-298503-l60cdllh 425 10 and and CC cord-298503-l60cdllh 425 11 endoplasmic endoplasmic NN cord-298503-l60cdllh 425 12 reticulum reticulum NN cord-298503-l60cdllh 425 13 subdomains subdomain NNS cord-298503-l60cdllh 425 14 in in IN cord-298503-l60cdllh 425 15 pancreatic pancreatic JJ cord-298503-l60cdllh 425 16 beta beta NN cord-298503-l60cdllh 425 17 cells cell NNS cord-298503-l60cdllh 425 18 of of IN cord-298503-l60cdllh 425 19 Akita Akita NNP cord-298503-l60cdllh 425 20 mice mouse NNS cord-298503-l60cdllh 426 1 Further further RB cord-298503-l60cdllh 426 2 Reading read VBG cord-298503-l60cdllh 426 3 Getting get VBG cord-298503-l60cdllh 426 4 into into IN cord-298503-l60cdllh 426 5 the the DT cord-298503-l60cdllh 426 6 Golgi Golgi NNP cord-298503-l60cdllh 426 7 Molecular Molecular NNP cord-298503-l60cdllh 426 8 motors motor NNS cord-298503-l60cdllh 426 9 and and CC cord-298503-l60cdllh 426 10 the the DT cord-298503-l60cdllh 426 11 Golgi Golgi NNP cord-298503-l60cdllh 426 12 complex complex NN cord-298503-l60cdllh 426 13 : : : cord-298503-l60cdllh 426 14 Staying stay VBG cord-298503-l60cdllh 426 15 put put VB cord-298503-l60cdllh 426 16 and and CC cord-298503-l60cdllh 426 17 moving move VBG cord-298503-l60cdllh 426 18 through through IN cord-298503-l60cdllh 426 19 The the DT cord-298503-l60cdllh 426 20 KDEL KDEL NNP cord-298503-l60cdllh 426 21 - - HYPH cord-298503-l60cdllh 426 22 receptor receptor NN cord-298503-l60cdllh 426 23 : : : cord-298503-l60cdllh 427 1 New new JJ cord-298503-l60cdllh 427 2 functions function NNS cord-298503-l60cdllh 427 3 for for IN cord-298503-l60cdllh 427 4 an an DT cord-298503-l60cdllh 427 5 old old JJ cord-298503-l60cdllh 427 6 protein protein NN cord-298503-l60cdllh 427 7 Protein Protein NNP cord-298503-l60cdllh 427 8 sorting sorting NN cord-298503-l60cdllh 427 9 receptors receptor NNS cord-298503-l60cdllh 427 10 in in IN cord-298503-l60cdllh 427 11 the the DT cord-298503-l60cdllh 427 12 early early JJ cord-298503-l60cdllh 427 13 secretory secretory JJ cord-298503-l60cdllh 427 14 pathway pathway NN cord-298503-l60cdllh 427 15 The the DT cord-298503-l60cdllh 427 16 Golgi Golgi NNP cord-298503-l60cdllh 427 17 apparatus apparatus NN cord-298503-l60cdllh 427 18 : : : cord-298503-l60cdllh 427 19 100 100 CD cord-298503-l60cdllh 427 20 years year NNS cord-298503-l60cdllh 427 21 of of IN cord-298503-l60cdllh 427 22 progress progress NN cord-298503-l60cdllh 427 23 and and CC cord-298503-l60cdllh 427 24 controversy controversy NN cord-298503-l60cdllh 427 25 Architecture Architecture NNP cord-298503-l60cdllh 427 26 of of IN cord-298503-l60cdllh 427 27 the the DT cord-298503-l60cdllh 427 28 mammalian mammalian JJ cord-298503-l60cdllh 427 29 Golgi Golgi NNP cord-298503-l60cdllh 427 30 Secretory Secretory NNP cord-298503-l60cdllh 427 31 protein protein NN cord-298503-l60cdllh 427 32 trafficking trafficking NN cord-298503-l60cdllh 427 33 and and CC cord-298503-l60cdllh 427 34 organelle organelle NN cord-298503-l60cdllh 427 35 dynamics dynamic NNS cord-298503-l60cdllh 427 36 in in IN cord-298503-l60cdllh 427 37 living living NN cord-298503-l60cdllh 427 38 cells cell NNS cord-298503-l60cdllh 427 39 COPII COPII NNP cord-298503-l60cdllh 427 40 and and CC cord-298503-l60cdllh 427 41 the the DT cord-298503-l60cdllh 427 42 regulation regulation NN cord-298503-l60cdllh 427 43 of of IN cord-298503-l60cdllh 427 44 protein protein NN cord-298503-l60cdllh 427 45 sorting sorting NN cord-298503-l60cdllh 427 46 in in IN cord-298503-l60cdllh 427 47 mammals mammal NNS