id	sid	tid	token	lemma	pos
cord-022313-2675sjlf	1	1	key	key	JJ
cord-022313-2675sjlf	1	2	:	:	:
cord-022313-2675sjlf	1	3	cord-022313	cord-022313	NNP
cord-022313-2675sjlf	1	4	-	-	HYPH
cord-022313-2675sjlf	1	5	2675sjlf	2675sjlf	CD
cord-022313-2675sjlf	1	6	authors	author	NNS
cord-022313-2675sjlf	1	7	:	:	:
cord-022313-2675sjlf	1	8	Elbein	Elbein	NNP
cord-022313-2675sjlf	1	9	,	,	,
cord-022313-2675sjlf	1	10	Alan	Alan	NNP
cord-022313-2675sjlf	1	11	D.	D.	NNP
cord-022313-2675sjlf	1	12	title	title	NN
cord-022313-2675sjlf	1	13	:	:	:
cord-022313-2675sjlf	1	14	The	the	DT
cord-022313-2675sjlf	1	15	Use	Use	NNP
cord-022313-2675sjlf	1	16	of	of	IN
cord-022313-2675sjlf	1	17	Glycosylation	Glycosylation	NNP
cord-022313-2675sjlf	1	18	Inhibitors	Inhibitors	NNPS
cord-022313-2675sjlf	1	19	to	to	TO
cord-022313-2675sjlf	1	20	Study	Study	NNP
cord-022313-2675sjlf	1	21	Glycoconjugate	Glycoconjugate	NNP
cord-022313-2675sjlf	1	22	Function	Function	NNP
cord-022313-2675sjlf	1	23	date	date	NN
cord-022313-2675sjlf	1	24	:	:	:
cord-022313-2675sjlf	1	25	2012	2012	CD
cord-022313-2675sjlf	1	26	-	-	SYM
cord-022313-2675sjlf	1	27	12	12	CD
cord-022313-2675sjlf	1	28	-	-	SYM
cord-022313-2675sjlf	1	29	02	02	CD
cord-022313-2675sjlf	1	30	journal	journal	NN
cord-022313-2675sjlf	1	31	:	:	:
cord-022313-2675sjlf	2	1	Cell	cell	NN
cord-022313-2675sjlf	2	2	Surface	Surface	NNP
cord-022313-2675sjlf	2	3	and	and	CC
cord-022313-2675sjlf	2	4	Extracellular	Extracellular	NNP
cord-022313-2675sjlf	2	5	Glycoconjugates	Glycoconjugates	NNPS
cord-022313-2675sjlf	2	6	DOI	DOI	NNP
cord-022313-2675sjlf	2	7	:	:	:
cord-022313-2675sjlf	2	8	10.1016	10.1016	CD
cord-022313-2675sjlf	2	9	/	/	SYM
cord-022313-2675sjlf	2	10	b978	b978	NN
cord-022313-2675sjlf	2	11	-	-	HYPH
cord-022313-2675sjlf	2	12	0	0	CD
cord-022313-2675sjlf	2	13	-	-	HYPH
cord-022313-2675sjlf	2	14	12	12	CD
cord-022313-2675sjlf	2	15	-	-	HYPH
cord-022313-2675sjlf	2	16	589630	589630	CD
cord-022313-2675sjlf	2	17	-	-	HYPH
cord-022313-2675sjlf	2	18	6.50009	6.50009	CD
cord-022313-2675sjlf	2	19	-	-	SYM
cord-022313-2675sjlf	2	20	5	5	CD
cord-022313-2675sjlf	3	1	sha	sha	NNP
cord-022313-2675sjlf	3	2	:	:	:
cord-022313-2675sjlf	4	1	293abc6b35a4e05e88ae452ef19e257dec0fbfda	293abc6b35a4e05e88ae452ef19e257dec0fbfda	CD
cord-022313-2675sjlf	4	2	doc_id	doc_id	CD
cord-022313-2675sjlf	4	3	:	:	:
cord-022313-2675sjlf	5	1	22313	22313	CD
cord-022313-2675sjlf	5	2	cord_uid	cord_uid	NNS
cord-022313-2675sjlf	5	3	:	:	:
cord-022313-2675sjlf	5	4	2675sjlf	2675sjlf	CD
cord-022313-2675sjlf	5	5	nan	nan	NNP
cord-022313-2675sjlf	5	6	physiological	physiological	JJ
cord-022313-2675sjlf	5	7	processes	process	NNS
cord-022313-2675sjlf	5	8	(	(	-LRB-
cord-022313-2675sjlf	5	9	7	7	CD
cord-022313-2675sjlf	5	10	,	,	,
cord-022313-2675sjlf	5	11	8)	8)	NN
cord-022313-2675sjlf	5	12	.	.	.
cord-022313-2675sjlf	6	1	The	the	DT
cord-022313-2675sjlf	6	2	fact	fact	NN
cord-022313-2675sjlf	6	3	that	that	IN
cord-022313-2675sjlf	6	4	these	these	DT
cord-022313-2675sjlf	6	5	many	many	JJ
cord-022313-2675sjlf	6	6	different	different	JJ
cord-022313-2675sjlf	6	7	systems	system	NNS
cord-022313-2675sjlf	6	8	have	have	VBP
cord-022313-2675sjlf	6	9	complex	complex	JJ
cord-022313-2675sjlf	6	10	carbohydrates	carbohydrate	NNS
cord-022313-2675sjlf	6	11	as	as	IN
cord-022313-2675sjlf	6	12	a	a	DT
cord-022313-2675sjlf	6	13	common	common	JJ
cord-022313-2675sjlf	6	14	theme	theme	NN
cord-022313-2675sjlf	6	15	has	have	VBZ
cord-022313-2675sjlf	6	16	given	give	VBN
cord-022313-2675sjlf	6	17	rise	rise	NN
cord-022313-2675sjlf	6	18	to	to	IN
cord-022313-2675sjlf	6	19	the	the	DT
cord-022313-2675sjlf	6	20	term	term	NN
cord-022313-2675sjlf	6	21	"	"	``
cord-022313-2675sjlf	6	22	glycobiology	glycobiology	NN
cord-022313-2675sjlf	6	23	,	,	,
cord-022313-2675sjlf	6	24	"	"	''
cord-022313-2675sjlf	6	25	which	which	WDT
cord-022313-2675sjlf	6	26	has	have	VBZ
cord-022313-2675sjlf	6	27	been	be	VBN
cord-022313-2675sjlf	6	28	defined	define	VBN
cord-022313-2675sjlf	6	29	as	as	IN
cord-022313-2675sjlf	6	30	"	"	``
cord-022313-2675sjlf	6	31	a	a	DT
cord-022313-2675sjlf	6	32	study	study	NN
cord-022313-2675sjlf	6	33	of	of	IN
cord-022313-2675sjlf	6	34	the	the	DT
cord-022313-2675sjlf	6	35	structure	structure	NN
cord-022313-2675sjlf	6	36	and	and	CC
cord-022313-2675sjlf	6	37	function	function	NN
cord-022313-2675sjlf	6	38	of	of	IN
cord-022313-2675sjlf	6	39	the	the	DT
cord-022313-2675sjlf	6	40	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	6	41	modifications	modification	NNS
cord-022313-2675sjlf	6	42	on	on	IN
cord-022313-2675sjlf	6	43	different	different	JJ
cord-022313-2675sjlf	6	44	types	type	NNS
cord-022313-2675sjlf	6	45	of	of	IN
cord-022313-2675sjlf	6	46	macromolecules	macromolecule	NNS
cord-022313-2675sjlf	6	47	"	"	''
cord-022313-2675sjlf	6	48	(	(	-LRB-
cord-022313-2675sjlf	6	49	9	9	CD
cord-022313-2675sjlf	6	50	)	)	-RRB-
cord-022313-2675sjlf	6	51	.	.	.
cord-022313-2675sjlf	7	1	Complex	complex	JJ
cord-022313-2675sjlf	7	2	carbohydrates	carbohydrate	NNS
cord-022313-2675sjlf	7	3	are	be	VBP
cord-022313-2675sjlf	7	4	found	find	VBN
cord-022313-2675sjlf	7	5	attached	attach	VBN
cord-022313-2675sjlf	7	6	both	both	DT
cord-022313-2675sjlf	7	7	to	to	IN
cord-022313-2675sjlf	7	8	proteins	protein	NNS
cord-022313-2675sjlf	7	9	and	and	CC
cord-022313-2675sjlf	7	10	to	to	IN
cord-022313-2675sjlf	7	11	lipids	lipid	NNS
cord-022313-2675sjlf	7	12	.	.	.
cord-022313-2675sjlf	8	1	The	the	DT
cord-022313-2675sjlf	8	2	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	8	3	produced	produce	VBN
cord-022313-2675sjlf	8	4	by	by	IN
cord-022313-2675sjlf	8	5	eucaryotic	eucaryotic	JJ
cord-022313-2675sjlf	8	6	cells	cell	NNS
cord-022313-2675sjlf	8	7	can	can	MD
cord-022313-2675sjlf	8	8	have	have	VB
cord-022313-2675sjlf	8	9	either	either	CC
cord-022313-2675sjlf	8	10	N	n	NN
cord-022313-2675sjlf	8	11	-	-	HYPH
cord-022313-2675sjlf	8	12	linked	link	VBN
cord-022313-2675sjlf	8	13	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	8	14	or	or	CC
cord-022313-2675sjlf	8	15	O	o	NN
cord-022313-2675sjlf	8	16	-	-	HYPH
cord-022313-2675sjlf	8	17	linked	link	VBN
cord-022313-2675sjlf	8	18	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	8	19	,	,	,
cord-022313-2675sjlf	8	20	and	and	CC
cord-022313-2675sjlf	8	21	frequently	frequently	RB
cord-022313-2675sjlf	8	22	both	both	DT
cord-022313-2675sjlf	8	23	types	type	NNS
cord-022313-2675sjlf	8	24	of	of	IN
cord-022313-2675sjlf	8	25	structures	structure	NNS
cord-022313-2675sjlf	8	26	are	be	VBP
cord-022313-2675sjlf	8	27	found	find	VBN
cord-022313-2675sjlf	8	28	on	on	IN
cord-022313-2675sjlf	8	29	the	the	DT
cord-022313-2675sjlf	8	30	same	same	JJ
cord-022313-2675sjlf	8	31	protein	protein	NN
cord-022313-2675sjlf	8	32	(	(	-LRB-
cord-022313-2675sjlf	8	33	10	10	CD
cord-022313-2675sjlf	8	34	)	)	-RRB-
cord-022313-2675sjlf	8	35	.	.	.
cord-022313-2675sjlf	9	1	In	in	IN
cord-022313-2675sjlf	9	2	addition	addition	NN
cord-022313-2675sjlf	9	3	,	,	,
cord-022313-2675sjlf	9	4	the	the	DT
cord-022313-2675sjlf	9	5	number	number	NN
cord-022313-2675sjlf	9	6	of	of	IN
cord-022313-2675sjlf	9	7	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	9	8	chains	chain	NNS
cord-022313-2675sjlf	9	9	attached	attach	VBN
cord-022313-2675sjlf	9	10	to	to	IN
cord-022313-2675sjlf	9	11	the	the	DT
cord-022313-2675sjlf	9	12	protein	protein	NN
cord-022313-2675sjlf	9	13	can	can	MD
cord-022313-2675sjlf	9	14	vary	vary	VB
cord-022313-2675sjlf	9	15	from	from	IN
cord-022313-2675sjlf	9	16	only	only	RB
cord-022313-2675sjlf	9	17	one	one	CD
cord-022313-2675sjlf	9	18	to	to	IN
cord-022313-2675sjlf	9	19	many	many	JJ
cord-022313-2675sjlf	9	20	chains	chain	NNS
cord-022313-2675sjlf	9	21	.	.	.
cord-022313-2675sjlf	10	1	In	in	IN
cord-022313-2675sjlf	10	2	the	the	DT
cord-022313-2675sjlf	10	3	N	n	NN
cord-022313-2675sjlf	10	4	-	-	HYPH
cord-022313-2675sjlf	10	5	linked	link	VBN
cord-022313-2675sjlf	10	6	types	type	NNS
cord-022313-2675sjlf	10	7	(	(	-LRB-
cord-022313-2675sjlf	10	8	described	describe	VBN
cord-022313-2675sjlf	10	9	in	in	IN
cord-022313-2675sjlf	10	10	more	more	JJR
cord-022313-2675sjlf	10	11	detail	detail	NN
cord-022313-2675sjlf	10	12	below	below	IN
cord-022313-2675sjlf	10	13	)	)	-RRB-
cord-022313-2675sjlf	10	14	,	,	,
cord-022313-2675sjlf	10	15	the	the	DT
cord-022313-2675sjlf	10	16	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	10	17	is	be	VBZ
cord-022313-2675sjlf	10	18	attached	attach	VBN
cord-022313-2675sjlf	10	19	to	to	IN
cord-022313-2675sjlf	10	20	the	the	DT
cord-022313-2675sjlf	10	21	amide	amide	NN
cord-022313-2675sjlf	10	22	nitrogen	nitrogen	NN
cord-022313-2675sjlf	10	23	of	of	IN
cord-022313-2675sjlf	10	24	asparagine	asparagine	NN
cord-022313-2675sjlf	10	25	residues	residue	NNS
cord-022313-2675sjlf	10	26	that	that	WDT
cord-022313-2675sjlf	10	27	occur	occur	VBP
cord-022313-2675sjlf	10	28	in	in	IN
cord-022313-2675sjlf	10	29	the	the	DT
cord-022313-2675sjlf	10	30	tripeptide	tripeptide	NN
cord-022313-2675sjlf	10	31	sequences	sequence	NNS
cord-022313-2675sjlf	10	32	,	,	,
cord-022313-2675sjlf	10	33	Asn	Asn	NNP
cord-022313-2675sjlf	10	34	-	-	HYPH
cord-022313-2675sjlf	10	35	X	X	NNP
cord-022313-2675sjlf	10	36	-	-	JJ
cord-022313-2675sjlf	10	37	Ser	ser	JJ
cord-022313-2675sjlf	10	38	(	(	-LRB-
cord-022313-2675sjlf	10	39	Thr)(ll	Thr)(ll	NNP
cord-022313-2675sjlf	10	40	)	)	-RRB-
cord-022313-2675sjlf	10	41	.	.	.
cord-022313-2675sjlf	11	1	However	however	RB
cord-022313-2675sjlf	11	2	,	,	,
cord-022313-2675sjlf	11	3	this	this	DT
cord-022313-2675sjlf	11	4	sequon	sequon	NN
cord-022313-2675sjlf	11	5	is	be	VBZ
cord-022313-2675sjlf	11	6	not	not	RB
cord-022313-2675sjlf	11	7	sufficient	sufficient	JJ
cord-022313-2675sjlf	11	8	for	for	IN
cord-022313-2675sjlf	11	9	glycosylation	glycosylation	NN
cord-022313-2675sjlf	11	10	to	to	TO
cord-022313-2675sjlf	11	11	occur	occur	VB
cord-022313-2675sjlf	11	12	since	since	IN
cord-022313-2675sjlf	11	13	many	many	JJ
cord-022313-2675sjlf	11	14	-Asn	-Asn	HYPH
cord-022313-2675sjlf	11	15	-	-	HYPH
cord-022313-2675sjlf	11	16	X	x	NN
cord-022313-2675sjlf	11	17	-	-	NNS
cord-022313-2675sjlf	11	18	Ser(Thr)-sequences	ser(thr)-sequence	NNS
cord-022313-2675sjlf	11	19	that	that	WDT
cord-022313-2675sjlf	11	20	are	be	VBP
cord-022313-2675sjlf	11	21	found	find	VBN
cord-022313-2675sjlf	11	22	in	in	IN
cord-022313-2675sjlf	11	23	pro	pro	JJ
cord-022313-2675sjlf	11	24	teins	tein	NNS
cord-022313-2675sjlf	11	25	are	be	VBP
cord-022313-2675sjlf	11	26	not	not	RB
cord-022313-2675sjlf	11	27	glycosylated	glycosylate	VBN
cord-022313-2675sjlf	11	28	.	.	.
cord-022313-2675sjlf	12	1	It	-PRON-	PRP
cord-022313-2675sjlf	12	2	appears	appear	VBZ
cord-022313-2675sjlf	12	3	that	that	IN
cord-022313-2675sjlf	12	4	the	the	DT
cord-022313-2675sjlf	12	5	conformation	conformation	NN
cord-022313-2675sjlf	12	6	of	of	IN
cord-022313-2675sjlf	12	7	the	the	DT
cord-022313-2675sjlf	12	8	protein	protein	NN
cord-022313-2675sjlf	12	9	around	around	IN
cord-022313-2675sjlf	12	10	this	this	DT
cord-022313-2675sjlf	12	11	sequence	sequence	NN
cord-022313-2675sjlf	12	12	and	and	CC
cord-022313-2675sjlf	12	13	perhaps	perhaps	RB
cord-022313-2675sjlf	12	14	its	-PRON-	PRP$
cord-022313-2675sjlf	12	15	exposure	exposure	NN
cord-022313-2675sjlf	12	16	are	be	VBP
cord-022313-2675sjlf	12	17	critical	critical	JJ
cord-022313-2675sjlf	12	18	factors	factor	NNS
cord-022313-2675sjlf	12	19	in	in	IN
cord-022313-2675sjlf	12	20	addition	addition	NN
cord-022313-2675sjlf	12	21	of	of	IN
cord-022313-2675sjlf	12	22	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	12	23	.	.	.
cord-022313-2675sjlf	13	1	On	on	IN
cord-022313-2675sjlf	13	2	the	the	DT
cord-022313-2675sjlf	13	3	other	other	JJ
cord-022313-2675sjlf	13	4	hand	hand	NN
cord-022313-2675sjlf	13	5	,	,	,
cord-022313-2675sjlf	13	6	in	in	IN
cord-022313-2675sjlf	13	7	the	the	DT
cord-022313-2675sjlf	13	8	more	more	RBR
cord-022313-2675sjlf	13	9	common	common	JJ
cord-022313-2675sjlf	13	10	types	type	NNS
cord-022313-2675sjlf	13	11	of	of	IN
cord-022313-2675sjlf	13	12	O	o	NN
cord-022313-2675sjlf	13	13	-	-	HYPH
cord-022313-2675sjlf	13	14	linked	link	VBN
cord-022313-2675sjlf	13	15	structures	structure	NNS
cord-022313-2675sjlf	13	16	such	such	JJ
cord-022313-2675sjlf	13	17	as	as	IN
cord-022313-2675sjlf	13	18	the	the	DT
cord-022313-2675sjlf	13	19	mucins	mucin	NNS
cord-022313-2675sjlf	13	20	,	,	,
cord-022313-2675sjlf	13	21	the	the	DT
cord-022313-2675sjlf	13	22	oligosac	oligosac	NNP
cord-022313-2675sjlf	13	23	charides	charides	NNP
cord-022313-2675sjlf	13	24	are	be	VBP
cord-022313-2675sjlf	13	25	attached	attach	VBN
cord-022313-2675sjlf	13	26	by	by	IN
cord-022313-2675sjlf	13	27	O	o	NN
cord-022313-2675sjlf	13	28	-	-	HYPH
cord-022313-2675sjlf	13	29	glycosidic	glycosidic	JJ
cord-022313-2675sjlf	13	30	bonds	bond	NNS
cord-022313-2675sjlf	13	31	that	that	WDT
cord-022313-2675sjlf	13	32	usually	usually	RB
cord-022313-2675sjlf	13	33	involve	involve	VBP
cord-022313-2675sjlf	13	34	GalNAc	galnac	NN
cord-022313-2675sjlf	13	35	linked	link	VBN
cord-022313-2675sjlf	13	36	to	to	IN
cord-022313-2675sjlf	13	37	the	the	DT
cord-022313-2675sjlf	13	38	OH	OH	NNP
cord-022313-2675sjlf	13	39	groups	group	NNS
cord-022313-2675sjlf	13	40	of	of	IN
cord-022313-2675sjlf	13	41	serine	serine	NN
cord-022313-2675sjlf	13	42	or	or	CC
cord-022313-2675sjlf	13	43	threonine	threonine	NN
cord-022313-2675sjlf	13	44	residues	residue	NNS
cord-022313-2675sjlf	13	45	,	,	,
cord-022313-2675sjlf	13	46	but	but	CC
cord-022313-2675sjlf	13	47	there	there	EX
cord-022313-2675sjlf	13	48	is	be	VBZ
cord-022313-2675sjlf	13	49	no	no	DT
cord-022313-2675sjlf	13	50	known	know	VBN
cord-022313-2675sjlf	13	51	amino	amino	NN
cord-022313-2675sjlf	13	52	acid	acid	NN
cord-022313-2675sjlf	13	53	sequence	sequence	NN
cord-022313-2675sjlf	13	54	necessary	necessary	JJ
cord-022313-2675sjlf	13	55	for	for	IN
cord-022313-2675sjlf	13	56	glycosylation	glycosylation	NN
cord-022313-2675sjlf	13	57	(	(	-LRB-
cord-022313-2675sjlf	13	58	12	12	CD
cord-022313-2675sjlf	13	59	)	)	-RRB-
cord-022313-2675sjlf	13	60	.	.	.
cord-022313-2675sjlf	14	1	In	in	IN
cord-022313-2675sjlf	14	2	terms	term	NNS
cord-022313-2675sjlf	14	3	of	of	IN
cord-022313-2675sjlf	14	4	lipids	lipid	NNS
cord-022313-2675sjlf	14	5	,	,	,
cord-022313-2675sjlf	14	6	the	the	DT
cord-022313-2675sjlf	14	7	best	well	RBS
cord-022313-2675sjlf	14	8	known	know	VBN
cord-022313-2675sjlf	14	9	and	and	CC
cord-022313-2675sjlf	14	10	most	most	RBS
cord-022313-2675sjlf	14	11	common	common	JJ
cord-022313-2675sjlf	14	12	types	type	NNS
cord-022313-2675sjlf	14	13	of	of	IN
cord-022313-2675sjlf	14	14	glycolipids	glycolipid	NNS
cord-022313-2675sjlf	14	15	are	be	VBP
cord-022313-2675sjlf	14	16	the	the	DT
cord-022313-2675sjlf	14	17	sphingolipids	sphingolipid	NNS
cord-022313-2675sjlf	14	18	,	,	,
cord-022313-2675sjlf	14	19	which	which	WDT
cord-022313-2675sjlf	14	20	contain	contain	VBP
cord-022313-2675sjlf	14	21	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	14	22	chains	chain	NNS
cord-022313-2675sjlf	14	23	com	com	NN
cord-022313-2675sjlf	14	24	posed	pose	VBN
cord-022313-2675sjlf	14	25	of	of	IN
cord-022313-2675sjlf	14	26	some	some	DT
cord-022313-2675sjlf	14	27	of	of	IN
cord-022313-2675sjlf	14	28	the	the	DT
cord-022313-2675sjlf	14	29	following	follow	VBG
cord-022313-2675sjlf	14	30	sugars	sugar	NNS
cord-022313-2675sjlf	14	31	:	:	:
cord-022313-2675sjlf	14	32	glucose	glucose	NN
cord-022313-2675sjlf	14	33	,	,	,
cord-022313-2675sjlf	14	34	galactose	galactose	NN
cord-022313-2675sjlf	14	35	,	,	,
cord-022313-2675sjlf	14	36	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	14	37	,	,	,
cord-022313-2675sjlf	14	38	GalNAc	GalNAc	NNP
cord-022313-2675sjlf	14	39	,	,	,
cord-022313-2675sjlf	14	40	sialic	sialic	JJ
cord-022313-2675sjlf	14	41	acid	acid	NN
cord-022313-2675sjlf	14	42	,	,	,
cord-022313-2675sjlf	14	43	and	and	CC
cord-022313-2675sjlf	14	44	fucose	fucose	NNP
cord-022313-2675sjlf	14	45	.	.	.
cord-022313-2675sjlf	15	1	These	these	DT
cord-022313-2675sjlf	15	2	sugars	sugar	NNS
cord-022313-2675sjlf	15	3	may	may	MD
cord-022313-2675sjlf	15	4	be	be	VB
cord-022313-2675sjlf	15	5	present	present	JJ
cord-022313-2675sjlf	15	6	in	in	IN
cord-022313-2675sjlf	15	7	various	various	JJ
cord-022313-2675sjlf	15	8	configurations	configuration	NNS
cord-022313-2675sjlf	15	9	and	and	CC
cord-022313-2675sjlf	15	10	combinations	combination	NNS
cord-022313-2675sjlf	15	11	and	and	CC
cord-022313-2675sjlf	15	12	are	be	VBP
cord-022313-2675sjlf	15	13	linked	link	VBN
cord-022313-2675sjlf	15	14	to	to	IN
cord-022313-2675sjlf	15	15	a	a	DT
cord-022313-2675sjlf	15	16	ceramide	ceramide	NN
cord-022313-2675sjlf	15	17	that	that	WDT
cord-022313-2675sjlf	15	18	is	be	VBZ
cord-022313-2675sjlf	15	19	made	make	VBN
cord-022313-2675sjlf	15	20	up	up	RP
cord-022313-2675sjlf	15	21	of	of	IN
cord-022313-2675sjlf	15	22	fatty	fatty	JJ
cord-022313-2675sjlf	15	23	acid	acid	NN
cord-022313-2675sjlf	15	24	and	and	CC
cord-022313-2675sjlf	15	25	sphingosine	sphingosine	NN
cord-022313-2675sjlf	15	26	.	.	.
cord-022313-2675sjlf	16	1	These	these	DT
cord-022313-2675sjlf	16	2	compounds	compound	NNS
cord-022313-2675sjlf	16	3	are	be	VBP
cord-022313-2675sjlf	16	4	of	of	IN
cord-022313-2675sjlf	16	5	considerable	considerable	JJ
cord-022313-2675sjlf	16	6	importance	importance	NN
cord-022313-2675sjlf	16	7	to	to	IN
cord-022313-2675sjlf	16	8	medicine	medicine	NN
cord-022313-2675sjlf	16	9	since	since	IN
cord-022313-2675sjlf	16	10	certain	certain	JJ
cord-022313-2675sjlf	16	11	gangliosides	ganglioside	NNS
cord-022313-2675sjlf	16	12	have	have	VBP
cord-022313-2675sjlf	16	13	been	be	VBN
cord-022313-2675sjlf	16	14	shown	show	VBN
cord-022313-2675sjlf	16	15	to	to	TO
cord-022313-2675sjlf	16	16	be	be	VB
cord-022313-2675sjlf	16	17	receptors	receptor	NNS
cord-022313-2675sjlf	16	18	for	for	IN
cord-022313-2675sjlf	16	19	diphtheria	diphtheria	NN
cord-022313-2675sjlf	16	20	and	and	CC
cord-022313-2675sjlf	16	21	cholera	cholera	NN
cord-022313-2675sjlf	16	22	toxins	toxin	NNS
cord-022313-2675sjlf	16	23	,	,	,
cord-022313-2675sjlf	16	24	while	while	IN
cord-022313-2675sjlf	16	25	some	some	DT
cord-022313-2675sjlf	16	26	cerebrosides	cerebroside	NNS
cord-022313-2675sjlf	16	27	are	be	VBP
cord-022313-2675sjlf	16	28	involved	involve	VBN
cord-022313-2675sjlf	16	29	in	in	IN
cord-022313-2675sjlf	16	30	bacterial	bacterial	JJ
cord-022313-2675sjlf	16	31	attachment	attachment	NN
cord-022313-2675sjlf	16	32	to	to	IN
cord-022313-2675sjlf	16	33	animal	animal	NN
cord-022313-2675sjlf	16	34	cells	cell	NNS
cord-022313-2675sjlf	16	35	.	.	.
cord-022313-2675sjlf	17	1	Since	since	IN
cord-022313-2675sjlf	17	2	a	a	DT
cord-022313-2675sjlf	17	3	number	number	NN
cord-022313-2675sjlf	17	4	of	of	IN
cord-022313-2675sjlf	17	5	current	current	JJ
cord-022313-2675sjlf	17	6	reviews	review	NNS
cord-022313-2675sjlf	17	7	have	have	VBP
cord-022313-2675sjlf	17	8	covered	cover	VBN
cord-022313-2675sjlf	17	9	these	these	DT
cord-022313-2675sjlf	17	10	compounds	compound	NNS
cord-022313-2675sjlf	17	11	in	in	IN
cord-022313-2675sjlf	17	12	detail	detail	NN
cord-022313-2675sjlf	17	13	,	,	,
cord-022313-2675sjlf	17	14	they	-PRON-	PRP
cord-022313-2675sjlf	17	15	will	will	MD
cord-022313-2675sjlf	17	16	not	not	RB
cord-022313-2675sjlf	17	17	be	be	VB
cord-022313-2675sjlf	17	18	considered	consider	VBN
cord-022313-2675sjlf	17	19	here	here	RB
cord-022313-2675sjlf	17	20	(	(	-LRB-
cord-022313-2675sjlf	17	21	13	13	CD
cord-022313-2675sjlf	17	22	,	,	,
cord-022313-2675sjlf	17	23	14	14	CD
cord-022313-2675sjlf	17	24	)	)	-RRB-
cord-022313-2675sjlf	17	25	.	.	.
cord-022313-2675sjlf	18	1	A	a	DT
cord-022313-2675sjlf	18	2	more	more	RBR
cord-022313-2675sjlf	18	3	recently	recently	RB
cord-022313-2675sjlf	18	4	de	de	FW
cord-022313-2675sjlf	18	5	scribed	scribe	VBN
cord-022313-2675sjlf	18	6	type	type	NN
cord-022313-2675sjlf	18	7	of	of	IN
cord-022313-2675sjlf	18	8	glycolipid	glycolipid	NNP
cord-022313-2675sjlf	18	9	is	be	VBZ
cord-022313-2675sjlf	18	10	the	the	DT
cord-022313-2675sjlf	18	11	glycosyl	glycosyl	JJ
cord-022313-2675sjlf	18	12	phosphatidylinositol	phosphatidylinositol	NN
cord-022313-2675sjlf	18	13	(	(	-LRB-
cord-022313-2675sjlf	18	14	GPI	GPI	NNP
cord-022313-2675sjlf	18	15	)	)	-RRB-
cord-022313-2675sjlf	18	16	type	type	NN
cord-022313-2675sjlf	18	17	,	,	,
cord-022313-2675sjlf	18	18	in	in	IN
cord-022313-2675sjlf	18	19	which	which	WDT
cord-022313-2675sjlf	18	20	a	a	DT
cord-022313-2675sjlf	18	21	glycan	glycan	NN
cord-022313-2675sjlf	18	22	of	of	IN
cord-022313-2675sjlf	18	23	mannose	mannose	NN
cord-022313-2675sjlf	18	24	and	and	CC
cord-022313-2675sjlf	18	25	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	18	26	(	(	-LRB-
cord-022313-2675sjlf	18	27	and	and	CC
cord-022313-2675sjlf	18	28	sometimes	sometimes	RB
cord-022313-2675sjlf	18	29	other	other	JJ
cord-022313-2675sjlf	18	30	sugars	sugar	NNS
cord-022313-2675sjlf	18	31	such	such	JJ
cord-022313-2675sjlf	18	32	as	as	IN
cord-022313-2675sjlf	18	33	galactose	galactose	NN
cord-022313-2675sjlf	18	34	)	)	-RRB-
cord-022313-2675sjlf	18	35	is	be	VBZ
cord-022313-2675sjlf	18	36	attached	attach	VBN
cord-022313-2675sjlf	18	37	to	to	IN
cord-022313-2675sjlf	18	38	the	the	DT
cord-022313-2675sjlf	18	39	membrane	membrane	NN
cord-022313-2675sjlf	18	40	phospholipid	phospholipid	NN
cord-022313-2675sjlf	18	41	phosphati	phosphati	NNP
cord-022313-2675sjlf	18	42	dylinositol	dylinositol	NNP
cord-022313-2675sjlf	18	43	.	.	.
cord-022313-2675sjlf	19	1	These	these	DT
cord-022313-2675sjlf	19	2	GPI	GPI	NNP
cord-022313-2675sjlf	19	3	molecules	molecule	NNS
cord-022313-2675sjlf	19	4	appear	appear	VBP
cord-022313-2675sjlf	19	5	to	to	TO
cord-022313-2675sjlf	19	6	be	be	VB
cord-022313-2675sjlf	19	7	important	important	JJ
cord-022313-2675sjlf	19	8	in	in	IN
cord-022313-2675sjlf	19	9	anchoring	anchor	VBG
cord-022313-2675sjlf	19	10	many	many	JJ
cord-022313-2675sjlf	19	11	proteins	protein	NNS
cord-022313-2675sjlf	19	12	to	to	IN
cord-022313-2675sjlf	19	13	the	the	DT
cord-022313-2675sjlf	19	14	membrane	membrane	NN
cord-022313-2675sjlf	19	15	(	(	-LRB-
cord-022313-2675sjlf	19	16	15	15	CD
cord-022313-2675sjlf	19	17	,	,	,
cord-022313-2675sjlf	19	18	16	16	CD
cord-022313-2675sjlf	19	19	)	)	-RRB-
cord-022313-2675sjlf	19	20	,	,	,
cord-022313-2675sjlf	19	21	and	and	CC
cord-022313-2675sjlf	19	22	some	some	DT
cord-022313-2675sjlf	19	23	of	of	IN
cord-022313-2675sjlf	19	24	the	the	DT
cord-022313-2675sjlf	19	25	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	19	26	of	of	IN
cord-022313-2675sjlf	19	27	Nlinked	Nlinked	NNP
cord-022313-2675sjlf	19	28	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	19	29	assembly	assembly	NN
cord-022313-2675sjlf	19	30	also	also	RB
cord-022313-2675sjlf	19	31	affect	affect	VBP
cord-022313-2675sjlf	19	32	the	the	DT
cord-022313-2675sjlf	19	33	synthesis	synthesis	NN
cord-022313-2675sjlf	19	34	of	of	IN
cord-022313-2675sjlf	19	35	the	the	DT
cord-022313-2675sjlf	19	36	glycan	glycan	NN
cord-022313-2675sjlf	19	37	portion	portion	NN
cord-022313-2675sjlf	19	38	of	of	IN
cord-022313-2675sjlf	19	39	these	these	DT
cord-022313-2675sjlf	19	40	anchors	anchor	NNS
cord-022313-2675sjlf	19	41	.	.	.
cord-022313-2675sjlf	20	1	They	-PRON-	PRP
cord-022313-2675sjlf	20	2	will	will	MD
cord-022313-2675sjlf	20	3	be	be	VB
cord-022313-2675sjlf	20	4	considered	consider	VBN
cord-022313-2675sjlf	20	5	in	in	IN
cord-022313-2675sjlf	20	6	more	more	JJR
cord-022313-2675sjlf	20	7	detail	detail	NN
cord-022313-2675sjlf	20	8	in	in	IN
cord-022313-2675sjlf	20	9	a	a	DT
cord-022313-2675sjlf	20	10	later	later	JJ
cord-022313-2675sjlf	20	11	section	section	NN
cord-022313-2675sjlf	20	12	.	.	.
cord-022313-2675sjlf	21	1	Although	although	IN
cord-022313-2675sjlf	21	2	a	a	DT
cord-022313-2675sjlf	21	3	considerable	considerable	JJ
cord-022313-2675sjlf	21	4	amount	amount	NN
cord-022313-2675sjlf	21	5	of	of	IN
cord-022313-2675sjlf	21	6	information	information	NN
cord-022313-2675sjlf	21	7	is	be	VBZ
cord-022313-2675sjlf	21	8	available	available	JJ
cord-022313-2675sjlf	21	9	concern	concern	NN
cord-022313-2675sjlf	21	10	ing	e	VBG
cord-022313-2675sjlf	21	11	the	the	DT
cord-022313-2675sjlf	21	12	structures	structure	NNS
cord-022313-2675sjlf	21	13	of	of	IN
cord-022313-2675sjlf	21	14	N	n	CD
cord-022313-2675sjlf	21	15	-	-	HYPH
cord-022313-2675sjlf	21	16	linked	link	VBN
cord-022313-2675sjlf	21	17	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	21	18	and	and	CC
cord-022313-2675sjlf	21	19	GPI	GPI	NNP
cord-022313-2675sjlf	21	20	glycans	glycan	NNS
cord-022313-2675sjlf	21	21	,	,	,
cord-022313-2675sjlf	21	22	there	there	EX
cord-022313-2675sjlf	21	23	is	be	VBZ
cord-022313-2675sjlf	21	24	relatively	relatively	RB
cord-022313-2675sjlf	21	25	little	little	JJ
cord-022313-2675sjlf	21	26	data	datum	NNS
cord-022313-2675sjlf	21	27	concerning	concern	VBG
cord-022313-2675sjlf	21	28	the	the	DT
cord-022313-2675sjlf	21	29	function	function	NN
cord-022313-2675sjlf	21	30	of	of	IN
cord-022313-2675sjlf	21	31	the	the	DT
cord-022313-2675sjlf	21	32	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	21	33	portion	portion	NN
cord-022313-2675sjlf	21	34	of	of	IN
cord-022313-2675sjlf	21	35	these	these	DT
cord-022313-2675sjlf	21	36	molecules	molecule	NNS
cord-022313-2675sjlf	21	37	.	.	.
cord-022313-2675sjlf	22	1	It	-PRON-	PRP
cord-022313-2675sjlf	22	2	appears	appear	VBZ
cord-022313-2675sjlf	22	3	that	that	IN
cord-022313-2675sjlf	22	4	protein	protein	NN
cord-022313-2675sjlf	22	5	(	(	-LRB-
cord-022313-2675sjlf	22	6	or	or	CC
cord-022313-2675sjlf	22	7	lipid	lipid	NN
cord-022313-2675sjlf	22	8	)	)	-RRB-
cord-022313-2675sjlf	22	9	glycosyla	glycosyla	NNP
cord-022313-2675sjlf	22	10	tion	tion	NN
cord-022313-2675sjlf	22	11	has	have	VBZ
cord-022313-2675sjlf	22	12	two	two	CD
cord-022313-2675sjlf	22	13	major	major	JJ
cord-022313-2675sjlf	22	14	roles	role	NNS
cord-022313-2675sjlf	22	15	:	:	:
cord-022313-2675sjlf	22	16	to	to	TO
cord-022313-2675sjlf	22	17	modulate	modulate	VB
cord-022313-2675sjlf	22	18	or	or	CC
cord-022313-2675sjlf	22	19	change	change	VB
cord-022313-2675sjlf	22	20	the	the	DT
cord-022313-2675sjlf	22	21	biochemical	biochemical	JJ
cord-022313-2675sjlf	22	22	proper	proper	JJ
cord-022313-2675sjlf	22	23	ties	tie	NNS
cord-022313-2675sjlf	22	24	of	of	IN
cord-022313-2675sjlf	22	25	these	these	DT
cord-022313-2675sjlf	22	26	molecules	molecule	NNS
cord-022313-2675sjlf	22	27	,	,	,
cord-022313-2675sjlf	22	28	including	include	VBG
cord-022313-2675sjlf	22	29	such	such	JJ
cord-022313-2675sjlf	22	30	parameters	parameter	NNS
cord-022313-2675sjlf	22	31	as	as	IN
cord-022313-2675sjlf	22	32	bioactivity	bioactivity	NN
cord-022313-2675sjlf	22	33	,	,	,
cord-022313-2675sjlf	22	34	fold	fold	VB
cord-022313-2675sjlf	22	35	ing	ing	DT
cord-022313-2675sjlf	22	36	,	,	,
cord-022313-2675sjlf	22	37	stability	stability	NN
cord-022313-2675sjlf	22	38	or	or	CC
cord-022313-2675sjlf	22	39	turnover	turnover	NN
cord-022313-2675sjlf	22	40	,	,	,
cord-022313-2675sjlf	22	41	immunoreactivity	immunoreactivity	NN
cord-022313-2675sjlf	22	42	,	,	,
cord-022313-2675sjlf	22	43	and	and	CC
cord-022313-2675sjlf	22	44	so	so	RB
cord-022313-2675sjlf	22	45	on	on	RB
cord-022313-2675sjlf	22	46	;	;	:
cord-022313-2675sjlf	22	47	and	and	CC
cord-022313-2675sjlf	22	48	to	to	TO
cord-022313-2675sjlf	22	49	serve	serve	VB
cord-022313-2675sjlf	22	50	as	as	IN
cord-022313-2675sjlf	22	51	a	a	DT
cord-022313-2675sjlf	22	52	determinant	determinant	NN
cord-022313-2675sjlf	22	53	in	in	IN
cord-022313-2675sjlf	22	54	molecular	molecular	JJ
cord-022313-2675sjlf	22	55	recognition	recognition	NN
cord-022313-2675sjlf	22	56	events	event	NNS
cord-022313-2675sjlf	22	57	,	,	,
cord-022313-2675sjlf	22	58	such	such	JJ
cord-022313-2675sjlf	22	59	as	as	IN
cord-022313-2675sjlf	22	60	lysosomal	lysosomal	JJ
cord-022313-2675sjlf	22	61	enzyme	enzyme	NN
cord-022313-2675sjlf	22	62	targeting	targeting	NN
cord-022313-2675sjlf	22	63	,	,	,
cord-022313-2675sjlf	22	64	parasite	parasite	NN
cord-022313-2675sjlf	22	65	or	or	CC
cord-022313-2675sjlf	22	66	symbiote	symbiote	NN
cord-022313-2675sjlf	22	67	binding	binding	NN
cord-022313-2675sjlf	22	68	or	or	CC
cord-022313-2675sjlf	22	69	adhesion	adhesion	NN
cord-022313-2675sjlf	22	70	to	to	TO
cord-022313-2675sjlf	22	71	host	host	NN
cord-022313-2675sjlf	22	72	cells	cell	NNS
cord-022313-2675sjlf	22	73	,	,	,
cord-022313-2675sjlf	22	74	attachment	attachment	NN
cord-022313-2675sjlf	22	75	of	of	IN
cord-022313-2675sjlf	22	76	toxins	toxin	NNS
cord-022313-2675sjlf	22	77	or	or	CC
cord-022313-2675sjlf	22	78	other	other	JJ
cord-022313-2675sjlf	22	79	biologically	biologically	RB
cord-022313-2675sjlf	22	80	important	important	JJ
cord-022313-2675sjlf	22	81	ligands	ligand	NNS
cord-022313-2675sjlf	22	82	to	to	IN
cord-022313-2675sjlf	22	83	cell	cell	NN
cord-022313-2675sjlf	22	84	surfaces	surface	NNS
cord-022313-2675sjlf	22	85	,	,	,
cord-022313-2675sjlf	22	86	and	and	CC
cord-022313-2675sjlf	22	87	so	so	RB
cord-022313-2675sjlf	22	88	on	on	RB
cord-022313-2675sjlf	22	89	(	(	-LRB-
cord-022313-2675sjlf	22	90	17	17	CD
cord-022313-2675sjlf	22	91	)	)	-RRB-
cord-022313-2675sjlf	22	92	.	.	.
cord-022313-2675sjlf	23	1	In	in	IN
cord-022313-2675sjlf	23	2	most	most	JJS
cord-022313-2675sjlf	23	3	cases	case	NNS
cord-022313-2675sjlf	23	4	,	,	,
cord-022313-2675sjlf	23	5	it	-PRON-	PRP
cord-022313-2675sjlf	23	6	has	have	VBZ
cord-022313-2675sjlf	23	7	been	be	VBN
cord-022313-2675sjlf	23	8	somewhat	somewhat	RB
cord-022313-2675sjlf	23	9	difficult	difficult	JJ
cord-022313-2675sjlf	23	10	to	to	TO
cord-022313-2675sjlf	23	11	demonstrate	demonstrate	VB
cord-022313-2675sjlf	23	12	a	a	DT
cord-022313-2675sjlf	23	13	func	func	NN
cord-022313-2675sjlf	23	14	tional	tional	JJ
cord-022313-2675sjlf	23	15	role	role	NN
cord-022313-2675sjlf	23	16	for	for	IN
cord-022313-2675sjlf	23	17	the	the	DT
cord-022313-2675sjlf	23	18	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	23	19	portion	portion	NN
cord-022313-2675sjlf	23	20	of	of	IN
cord-022313-2675sjlf	23	21	the	the	DT
cord-022313-2675sjlf	23	22	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	23	23	.	.	.
cord-022313-2675sjlf	24	1	One	one	CD
cord-022313-2675sjlf	24	2	obvious	obvious	JJ
cord-022313-2675sjlf	24	3	way	way	NN
cord-022313-2675sjlf	24	4	to	to	TO
cord-022313-2675sjlf	24	5	do	do	VB
cord-022313-2675sjlf	24	6	this	this	DT
cord-022313-2675sjlf	24	7	would	would	MD
cord-022313-2675sjlf	24	8	be	be	VB
cord-022313-2675sjlf	24	9	to	to	TO
cord-022313-2675sjlf	24	10	obtain	obtain	VB
cord-022313-2675sjlf	24	11	the	the	DT
cord-022313-2675sjlf	24	12	particular	particular	JJ
cord-022313-2675sjlf	24	13	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	24	14	without	without	IN
cord-022313-2675sjlf	24	15	its	-PRON-	PRP$
cord-022313-2675sjlf	24	16	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	24	17	and	and	CC
cord-022313-2675sjlf	24	18	then	then	RB
cord-022313-2675sjlf	24	19	compare	compare	VB
cord-022313-2675sjlf	24	20	the	the	DT
cord-022313-2675sjlf	24	21	biological	biological	JJ
cord-022313-2675sjlf	24	22	and	and	CC
cord-022313-2675sjlf	24	23	biochemical	biochemical	JJ
cord-022313-2675sjlf	24	24	prop	prop	NN
cord-022313-2675sjlf	24	25	erties	ertie	NNS
cord-022313-2675sjlf	24	26	of	of	IN
cord-022313-2675sjlf	24	27	the	the	DT
cord-022313-2675sjlf	24	28	unglycosylated	unglycosylated	JJ
cord-022313-2675sjlf	24	29	form	form	NN
cord-022313-2675sjlf	24	30	with	with	IN
cord-022313-2675sjlf	24	31	those	those	DT
cord-022313-2675sjlf	24	32	of	of	IN
cord-022313-2675sjlf	24	33	the	the	DT
cord-022313-2675sjlf	24	34	normal	normal	JJ
cord-022313-2675sjlf	24	35	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	24	36	.	.	.
cord-022313-2675sjlf	25	1	There	there	EX
cord-022313-2675sjlf	25	2	are	be	VBP
cord-022313-2675sjlf	25	3	a	a	DT
cord-022313-2675sjlf	25	4	number	number	NN
cord-022313-2675sjlf	25	5	of	of	IN
cord-022313-2675sjlf	25	6	ways	way	NNS
cord-022313-2675sjlf	25	7	to	to	TO
cord-022313-2675sjlf	25	8	produce	produce	VB
cord-022313-2675sjlf	25	9	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	25	10	without	without	IN
cord-022313-2675sjlf	25	11	their	-PRON-	PRP$
cord-022313-2675sjlf	25	12	associated	associate	VBN
cord-022313-2675sjlf	25	13	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	25	14	,	,	,
cord-022313-2675sjlf	25	15	especially	especially	RB
cord-022313-2675sjlf	25	16	in	in	IN
cord-022313-2675sjlf	25	17	the	the	DT
cord-022313-2675sjlf	25	18	case	case	NN
cord-022313-2675sjlf	25	19	of	of	IN
cord-022313-2675sjlf	25	20	the	the	DT
cord-022313-2675sjlf	25	21	N	N	NNP
cord-022313-2675sjlf	25	22	-	-	HYPH
cord-022313-2675sjlf	25	23	linked	link	VBN
cord-022313-2675sjlf	25	24	glycopro	glycopro	NNP
cord-022313-2675sjlf	25	25	teins	tein	NNS
cord-022313-2675sjlf	25	26	.	.	.
cord-022313-2675sjlf	26	1	For	for	IN
cord-022313-2675sjlf	26	2	example	example	NN
cord-022313-2675sjlf	26	3	,	,	,
cord-022313-2675sjlf	26	4	one	one	PRP
cord-022313-2675sjlf	26	5	can	can	MD
cord-022313-2675sjlf	26	6	remove	remove	VB
cord-022313-2675sjlf	26	7	the	the	DT
cord-022313-2675sjlf	26	8	N	n	NN
cord-022313-2675sjlf	26	9	-	-	HYPH
cord-022313-2675sjlf	26	10	linked	link	VBN
cord-022313-2675sjlf	26	11	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	26	12	with	with	IN
cord-022313-2675sjlf	26	13	endoglycosidases	endoglycosidase	NNS
cord-022313-2675sjlf	26	14	,	,	,
cord-022313-2675sjlf	26	15	such	such	JJ
cord-022313-2675sjlf	26	16	as	as	IN
cord-022313-2675sjlf	26	17	endoglucosaminidase	endoglucosaminidase	NN
cord-022313-2675sjlf	26	18	H	H	NNP
cord-022313-2675sjlf	26	19	(	(	-LRB-
cord-022313-2675sjlf	26	20	Endo	Endo	NNP
cord-022313-2675sjlf	26	21	H	H	NNP
cord-022313-2675sjlf	26	22	)	)	-RRB-
cord-022313-2675sjlf	26	23	,	,	,
cord-022313-2675sjlf	26	24	which	which	WDT
cord-022313-2675sjlf	26	25	cleaves	cleave	VBZ
cord-022313-2675sjlf	26	26	"	"	``
cord-022313-2675sjlf	26	27	high	high	JJ
cord-022313-2675sjlf	26	28	-	-	HYPH
cord-022313-2675sjlf	26	29	mannose	mannose	NN
cord-022313-2675sjlf	26	30	"	"	''
cord-022313-2675sjlf	26	31	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	26	32	between	between	IN
cord-022313-2675sjlf	26	33	the	the	DT
cord-022313-2675sjlf	26	34	two	two	CD
cord-022313-2675sjlf	26	35	internal	internal	JJ
cord-022313-2675sjlf	26	36	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	26	37	residues	residue	NNS
cord-022313-2675sjlf	26	38	(	(	-LRB-
cord-022313-2675sjlf	26	39	18	18	CD
cord-022313-2675sjlf	26	40	)	)	-RRB-
cord-022313-2675sjlf	26	41	,	,	,
cord-022313-2675sjlf	26	42	or	or	CC
cord-022313-2675sjlf	26	43	peptide	peptide	JJ
cord-022313-2675sjlf	26	44	glycosidase	glycosidase	NN
cord-022313-2675sjlf	26	45	F	F	NNP
cord-022313-2675sjlf	26	46	,	,	,
cord-022313-2675sjlf	26	47	which	which	WDT
cord-022313-2675sjlf	26	48	hydrolyzes	hydrolyze	VBZ
cord-022313-2675sjlf	26	49	most	most	JJS
cord-022313-2675sjlf	26	50	N	n	CD
cord-022313-2675sjlf	26	51	-	-	HYPH
cord-022313-2675sjlf	26	52	linked	link	VBN
cord-022313-2675sjlf	26	53	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	26	54	at	at	IN
cord-022313-2675sjlf	26	55	the	the	DT
cord-022313-2675sjlf	26	56	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	26	57	to	to	IN
cord-022313-2675sjlf	26	58	asparagine	asparagine	NN
cord-022313-2675sjlf	26	59	bond	bond	NN
cord-022313-2675sjlf	26	60	(	(	-LRB-
cord-022313-2675sjlf	26	61	19	19	CD
cord-022313-2675sjlf	26	62	)	)	-RRB-
cord-022313-2675sjlf	26	63	.	.	.
cord-022313-2675sjlf	27	1	The	the	DT
cord-022313-2675sjlf	27	2	problem	problem	NN
cord-022313-2675sjlf	27	3	with	with	IN
cord-022313-2675sjlf	27	4	this	this	DT
cord-022313-2675sjlf	27	5	approach	approach	NN
cord-022313-2675sjlf	27	6	is	be	VBZ
cord-022313-2675sjlf	27	7	that	that	IN
cord-022313-2675sjlf	27	8	many	many	JJ
cord-022313-2675sjlf	27	9	N	n	CD
cord-022313-2675sjlf	27	10	-	-	HYPH
cord-022313-2675sjlf	27	11	linked	link	VBN
cord-022313-2675sjlf	27	12	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	27	13	are	be	VBP
cord-022313-2675sjlf	27	14	resistant	resistant	JJ
cord-022313-2675sjlf	27	15	to	to	IN
cord-022313-2675sjlf	27	16	cleavage	cleavage	NN
cord-022313-2675sjlf	27	17	by	by	IN
cord-022313-2675sjlf	27	18	these	these	DT
cord-022313-2675sjlf	27	19	enzymes	enzyme	NNS
cord-022313-2675sjlf	27	20	when	when	WRB
cord-022313-2675sjlf	27	21	the	the	DT
cord-022313-2675sjlf	27	22	protein	protein	NN
cord-022313-2675sjlf	27	23	is	be	VBZ
cord-022313-2675sjlf	27	24	in	in	IN
cord-022313-2675sjlf	27	25	its	-PRON-	PRP$
cord-022313-2675sjlf	27	26	native	native	JJ
cord-022313-2675sjlf	27	27	state	state	NN
cord-022313-2675sjlf	27	28	.	.	.
cord-022313-2675sjlf	28	1	Therefore	therefore	RB
cord-022313-2675sjlf	28	2	,	,	,
cord-022313-2675sjlf	28	3	it	-PRON-	PRP
cord-022313-2675sjlf	28	4	is	be	VBZ
cord-022313-2675sjlf	28	5	necessary	necessary	JJ
cord-022313-2675sjlf	28	6	to	to	TO
cord-022313-2675sjlf	28	7	denature	denature	VB
cord-022313-2675sjlf	28	8	the	the	DT
cord-022313-2675sjlf	28	9	protein	protein	NN
cord-022313-2675sjlf	28	10	in	in	IN
cord-022313-2675sjlf	28	11	order	order	NN
cord-022313-2675sjlf	28	12	to	to	TO
cord-022313-2675sjlf	28	13	obtain	obtain	VB
cord-022313-2675sjlf	28	14	complete	complete	JJ
cord-022313-2675sjlf	28	15	removal	removal	NN
cord-022313-2675sjlf	28	16	of	of	IN
cord-022313-2675sjlf	28	17	the	the	DT
cord-022313-2675sjlf	28	18	N	n	NN
cord-022313-2675sjlf	28	19	-	-	HYPH
cord-022313-2675sjlf	28	20	linked	link	VBN
cord-022313-2675sjlf	28	21	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	28	22	,	,	,
cord-022313-2675sjlf	28	23	making	make	VBG
cord-022313-2675sjlf	28	24	this	this	DT
cord-022313-2675sjlf	28	25	method	method	NN
cord-022313-2675sjlf	28	26	untenable	untenable	JJ
cord-022313-2675sjlf	28	27	for	for	IN
cord-022313-2675sjlf	28	28	functional	functional	JJ
cord-022313-2675sjlf	28	29	studies	study	NNS
cord-022313-2675sjlf	28	30	.	.	.
cord-022313-2675sjlf	29	1	Another	another	DT
cord-022313-2675sjlf	29	2	problem	problem	NN
cord-022313-2675sjlf	29	3	with	with	IN
cord-022313-2675sjlf	29	4	this	this	DT
cord-022313-2675sjlf	29	5	approach	approach	NN
cord-022313-2675sjlf	29	6	is	be	VBZ
cord-022313-2675sjlf	29	7	that	that	IN
cord-022313-2675sjlf	29	8	removing	remove	VBG
cord-022313-2675sjlf	29	9	the	the	DT
cord-022313-2675sjlf	29	10	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	29	11	after	after	IN
cord-022313-2675sjlf	29	12	the	the	DT
cord-022313-2675sjlf	29	13	protein	protein	NN
cord-022313-2675sjlf	29	14	has	have	VBZ
cord-022313-2675sjlf	29	15	been	be	VBN
cord-022313-2675sjlf	29	16	synthesized	synthesize	VBN
cord-022313-2675sjlf	29	17	and	and	CC
cord-022313-2675sjlf	29	18	has	have	VBZ
cord-022313-2675sjlf	29	19	achieved	achieve	VBN
cord-022313-2675sjlf	29	20	its	-PRON-	PRP$
cord-022313-2675sjlf	29	21	proper	proper	JJ
cord-022313-2675sjlf	29	22	conformation	conformation	NN
cord-022313-2675sjlf	29	23	may	may	MD
cord-022313-2675sjlf	29	24	be	be	VB
cord-022313-2675sjlf	29	25	quite	quite	RB
cord-022313-2675sjlf	29	26	different	different	JJ
cord-022313-2675sjlf	29	27	physiologically	physiologically	RB
cord-022313-2675sjlf	29	28	than	than	IN
cord-022313-2675sjlf	29	29	having	have	VBG
cord-022313-2675sjlf	29	30	the	the	DT
cord-022313-2675sjlf	29	31	protein	protein	NN
cord-022313-2675sjlf	29	32	synthesized	synthesize	VBN
cord-022313-2675sjlf	29	33	in	in	IN
cord-022313-2675sjlf	29	34	the	the	DT
cord-022313-2675sjlf	29	35	cell	cell	NN
cord-022313-2675sjlf	29	36	in	in	IN
cord-022313-2675sjlf	29	37	the	the	DT
cord-022313-2675sjlf	29	38	absence	absence	NN
cord-022313-2675sjlf	29	39	of	of	IN
cord-022313-2675sjlf	29	40	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	29	41	.	.	.
cord-022313-2675sjlf	30	1	A	a	DT
cord-022313-2675sjlf	30	2	second	second	JJ
cord-022313-2675sjlf	30	3	possibility	possibility	NN
cord-022313-2675sjlf	30	4	is	be	VBZ
cord-022313-2675sjlf	30	5	to	to	TO
cord-022313-2675sjlf	30	6	produce	produce	VB
cord-022313-2675sjlf	30	7	the	the	DT
cord-022313-2675sjlf	30	8	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	30	9	of	of	IN
cord-022313-2675sjlf	30	10	interest	interest	NN
cord-022313-2675sjlf	30	11	in	in	IN
cord-022313-2675sjlf	30	12	a	a	DT
cord-022313-2675sjlf	30	13	cell	cell	NN
cord-022313-2675sjlf	30	14	system	system	NN
cord-022313-2675sjlf	30	15	in	in	IN
cord-022313-2675sjlf	30	16	the	the	DT
cord-022313-2675sjlf	30	17	presence	presence	NN
cord-022313-2675sjlf	30	18	of	of	IN
cord-022313-2675sjlf	30	19	the	the	DT
cord-022313-2675sjlf	30	20	antibiotic	antibiotic	JJ
cord-022313-2675sjlf	30	21	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	30	22	(	(	-LRB-
cord-022313-2675sjlf	30	23	20	20	CD
cord-022313-2675sjlf	30	24	)	)	-RRB-
cord-022313-2675sjlf	30	25	.	.	.
cord-022313-2675sjlf	31	1	This	this	DT
cord-022313-2675sjlf	31	2	compound	compound	NN
cord-022313-2675sjlf	31	3	inhibits	inhibit	VBZ
cord-022313-2675sjlf	31	4	the	the	DT
cord-022313-2675sjlf	31	5	GlcNAc-1-P	glcnac-1-p	JJ
cord-022313-2675sjlf	31	6	transferase	transferase	NN
cord-022313-2675sjlf	31	7	that	that	WDT
cord-022313-2675sjlf	31	8	catalyzes	catalyze	VBZ
cord-022313-2675sjlf	31	9	the	the	DT
cord-022313-2675sjlf	31	10	first	first	JJ
cord-022313-2675sjlf	31	11	step	step	NN
cord-022313-2675sjlf	31	12	in	in	IN
cord-022313-2675sjlf	31	13	the	the	DT
cord-022313-2675sjlf	31	14	"	"	``
cord-022313-2675sjlf	31	15	dolichol	dolichol	JJ
cord-022313-2675sjlf	31	16	cycle	cycle	NN
cord-022313-2675sjlf	31	17	,	,	,
cord-022313-2675sjlf	31	18	"	"	''
cord-022313-2675sjlf	31	19	thereby	thereby	RB
cord-022313-2675sjlf	31	20	preventing	prevent	VBG
cord-022313-2675sjlf	31	21	the	the	DT
cord-022313-2675sjlf	31	22	formation	formation	NN
cord-022313-2675sjlf	31	23	of	of	IN
cord-022313-2675sjlf	31	24	lipidlinked	lipidlinked	JJ
cord-022313-2675sjlf	31	25	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	31	26	(	(	-LRB-
cord-022313-2675sjlf	31	27	21	21	CD
cord-022313-2675sjlf	31	28	)	)	-RRB-
cord-022313-2675sjlf	31	29	.	.	.
cord-022313-2675sjlf	32	1	This	this	DT
cord-022313-2675sjlf	32	2	inhibition	inhibition	NN
cord-022313-2675sjlf	32	3	usually	usually	RB
cord-022313-2675sjlf	32	4	results	result	VBZ
cord-022313-2675sjlf	32	5	in	in	IN
cord-022313-2675sjlf	32	6	a	a	DT
cord-022313-2675sjlf	32	7	com	com	NN
cord-022313-2675sjlf	32	8	plete	plete	NN
cord-022313-2675sjlf	32	9	blockage	blockage	NN
cord-022313-2675sjlf	32	10	in	in	IN
cord-022313-2675sjlf	32	11	N	n	NN
cord-022313-2675sjlf	32	12	-	-	HYPH
cord-022313-2675sjlf	32	13	linked	link	VBN
cord-022313-2675sjlf	32	14	glycosylation	glycosylation	NN
cord-022313-2675sjlf	32	15	(	(	-LRB-
cord-022313-2675sjlf	32	16	22	22	CD
cord-022313-2675sjlf	32	17	)	)	-RRB-
cord-022313-2675sjlf	32	18	.	.	.
cord-022313-2675sjlf	33	1	The	the	DT
cord-022313-2675sjlf	33	2	difficulty	difficulty	NN
cord-022313-2675sjlf	33	3	with	with	IN
cord-022313-2675sjlf	33	4	this	this	DT
cord-022313-2675sjlf	33	5	approach	approach	NN
cord-022313-2675sjlf	33	6	is	be	VBZ
cord-022313-2675sjlf	33	7	that	that	IN
cord-022313-2675sjlf	33	8	many	many	JJ
cord-022313-2675sjlf	33	9	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	33	10	may	may	MD
cord-022313-2675sjlf	33	11	be	be	VB
cord-022313-2675sjlf	33	12	improperly	improperly	RB
cord-022313-2675sjlf	33	13	folded	fold	VBN
cord-022313-2675sjlf	33	14	or	or	CC
cord-022313-2675sjlf	33	15	be	be	VB
cord-022313-2675sjlf	33	16	come	come	VBN
cord-022313-2675sjlf	33	17	insoluble	insoluble	JJ
cord-022313-2675sjlf	33	18	when	when	WRB
cord-022313-2675sjlf	33	19	they	-PRON-	PRP
cord-022313-2675sjlf	33	20	are	be	VBP
cord-022313-2675sjlf	33	21	synthesized	synthesize	VBN
cord-022313-2675sjlf	33	22	without	without	IN
cord-022313-2675sjlf	33	23	any	any	DT
cord-022313-2675sjlf	33	24	N	N	NNP
cord-022313-2675sjlf	33	25	-	-	HYPH
cord-022313-2675sjlf	33	26	linked	link	VBN
cord-022313-2675sjlf	33	27	carbo	carbo	NN
cord-022313-2675sjlf	33	28	hydrate	hydrate	NN
cord-022313-2675sjlf	33	29	.	.	.
cord-022313-2675sjlf	34	1	As	as	IN
cord-022313-2675sjlf	34	2	a	a	DT
cord-022313-2675sjlf	34	3	result	result	NN
cord-022313-2675sjlf	34	4	,	,	,
cord-022313-2675sjlf	34	5	physiological	physiological	JJ
cord-022313-2675sjlf	34	6	studies	study	NNS
cord-022313-2675sjlf	34	7	again	again	RB
cord-022313-2675sjlf	34	8	become	become	VBN
cord-022313-2675sjlf	34	9	of	of	IN
cord-022313-2675sjlf	34	10	questionable	questionable	JJ
cord-022313-2675sjlf	34	11	value	value	NN
cord-022313-2675sjlf	34	12	.	.	.
cord-022313-2675sjlf	35	1	A	a	DT
cord-022313-2675sjlf	35	2	third	third	JJ
cord-022313-2675sjlf	35	3	alternative	alternative	NN
cord-022313-2675sjlf	35	4	for	for	IN
cord-022313-2675sjlf	35	5	preventing	prevent	VBG
cord-022313-2675sjlf	35	6	glycosylation	glycosylation	NN
cord-022313-2675sjlf	35	7	is	be	VBZ
cord-022313-2675sjlf	35	8	to	to	TO
cord-022313-2675sjlf	35	9	use	use	VB
cord-022313-2675sjlf	35	10	site	site	NN
cord-022313-2675sjlf	35	11	-	-	HYPH
cord-022313-2675sjlf	35	12	directed	direct	VBN
cord-022313-2675sjlf	35	13	mutagenesis	mutagenesis	NN
cord-022313-2675sjlf	35	14	to	to	TO
cord-022313-2675sjlf	35	15	modify	modify	VB
cord-022313-2675sjlf	35	16	the	the	DT
cord-022313-2675sjlf	35	17	Asn	Asn	NNP
cord-022313-2675sjlf	35	18	-	-	HYPH
cord-022313-2675sjlf	35	19	X	X	NNP
cord-022313-2675sjlf	35	20	-	-	JJ
cord-022313-2675sjlf	35	21	Ser	ser	JJ
cord-022313-2675sjlf	35	22	sequon(s	sequon(s	NNP
cord-022313-2675sjlf	35	23	)	)	-RRB-
cord-022313-2675sjlf	35	24	that	that	WDT
cord-022313-2675sjlf	35	25	is	be	VBZ
cord-022313-2675sjlf	35	26	glycosylated	glycosylate	VBN
cord-022313-2675sjlf	35	27	to	to	IN
cord-022313-2675sjlf	35	28	one	one	CD
cord-022313-2675sjlf	35	29	that	that	WDT
cord-022313-2675sjlf	35	30	is	be	VBZ
cord-022313-2675sjlf	35	31	a	a	DT
cord-022313-2675sjlf	35	32	"	"	``
cord-022313-2675sjlf	35	33	non	non	JJ
cord-022313-2675sjlf	35	34	-	-	JJ
cord-022313-2675sjlf	35	35	acceptor	acceptor	JJ
cord-022313-2675sjlf	35	36	"	"	``
cord-022313-2675sjlf	35	37	sequon	sequon	JJ
cord-022313-2675sjlf	35	38	(	(	-LRB-
cord-022313-2675sjlf	35	39	23	23	CD
cord-022313-2675sjlf	35	40	,	,	,
cord-022313-2675sjlf	35	41	24	24	CD
cord-022313-2675sjlf	35	42	)	)	-RRB-
cord-022313-2675sjlf	35	43	.	.	.
cord-022313-2675sjlf	36	1	The	the	DT
cord-022313-2675sjlf	36	2	beauty	beauty	NN
cord-022313-2675sjlf	36	3	of	of	IN
cord-022313-2675sjlf	36	4	this	this	DT
cord-022313-2675sjlf	36	5	method	method	NN
cord-022313-2675sjlf	36	6	is	be	VBZ
cord-022313-2675sjlf	36	7	that	that	IN
cord-022313-2675sjlf	36	8	one	one	PRP
cord-022313-2675sjlf	36	9	can	can	MD
cord-022313-2675sjlf	36	10	modify	modify	VB
cord-022313-2675sjlf	36	11	one	one	CD
cord-022313-2675sjlf	36	12	glycosylation	glycosylation	NN
cord-022313-2675sjlf	36	13	site	site	NN
cord-022313-2675sjlf	36	14	at	at	IN
cord-022313-2675sjlf	36	15	a	a	DT
cord-022313-2675sjlf	36	16	time	time	NN
cord-022313-2675sjlf	36	17	(	(	-LRB-
cord-022313-2675sjlf	36	18	assuming	assume	VBG
cord-022313-2675sjlf	36	19	that	that	IN
cord-022313-2675sjlf	36	20	there	there	EX
cord-022313-2675sjlf	36	21	is	be	VBZ
cord-022313-2675sjlf	36	22	more	more	JJR
cord-022313-2675sjlf	36	23	than	than	IN
cord-022313-2675sjlf	36	24	one	one	CD
cord-022313-2675sjlf	36	25	)	)	-RRB-
cord-022313-2675sjlf	36	26	and	and	CC
cord-022313-2675sjlf	36	27	determine	determine	VB
cord-022313-2675sjlf	36	28	how	how	WRB
cord-022313-2675sjlf	36	29	an	an	DT
cord-022313-2675sjlf	36	30	alteration	alteration	NN
cord-022313-2675sjlf	36	31	at	at	IN
cord-022313-2675sjlf	36	32	that	that	DT
cord-022313-2675sjlf	36	33	site	site	NN
cord-022313-2675sjlf	36	34	affects	affect	VBZ
cord-022313-2675sjlf	36	35	function	function	NN
cord-022313-2675sjlf	36	36	.	.	.
cord-022313-2675sjlf	37	1	Or	or	CC
cord-022313-2675sjlf	37	2	one	one	PRP
cord-022313-2675sjlf	37	3	can	can	MD
cord-022313-2675sjlf	37	4	modify	modify	VB
cord-022313-2675sjlf	37	5	any	any	DT
cord-022313-2675sjlf	37	6	number	number	NN
cord-022313-2675sjlf	37	7	of	of	IN
cord-022313-2675sjlf	37	8	these	these	DT
cord-022313-2675sjlf	37	9	sites	site	NNS
cord-022313-2675sjlf	37	10	at	at	IN
cord-022313-2675sjlf	37	11	the	the	DT
cord-022313-2675sjlf	37	12	same	same	JJ
cord-022313-2675sjlf	37	13	time	time	NN
cord-022313-2675sjlf	37	14	and	and	CC
cord-022313-2675sjlf	37	15	compare	compare	VB
cord-022313-2675sjlf	37	16	the	the	DT
cord-022313-2675sjlf	37	17	various	various	JJ
cord-022313-2675sjlf	37	18	proteins	protein	NNS
cord-022313-2675sjlf	37	19	.	.	.
cord-022313-2675sjlf	38	1	Two	two	CD
cord-022313-2675sjlf	38	2	potential	potential	JJ
cord-022313-2675sjlf	38	3	obstacles	obstacle	NNS
cord-022313-2675sjlf	38	4	are	be	VBP
cord-022313-2675sjlf	38	5	(	(	-LRB-
cord-022313-2675sjlf	38	6	1	1	CD
cord-022313-2675sjlf	38	7	)	)	-RRB-
cord-022313-2675sjlf	39	1	the	the	DT
cord-022313-2675sjlf	39	2	gene	gene	NN
cord-022313-2675sjlf	39	3	coding	code	VBG
cord-022313-2675sjlf	39	4	for	for	IN
cord-022313-2675sjlf	39	5	the	the	DT
cord-022313-2675sjlf	39	6	protein	protein	NN
cord-022313-2675sjlf	39	7	of	of	IN
cord-022313-2675sjlf	39	8	interest	interest	NN
cord-022313-2675sjlf	39	9	must	must	MD
cord-022313-2675sjlf	39	10	be	be	VB
cord-022313-2675sjlf	39	11	available	available	JJ
cord-022313-2675sjlf	39	12	and	and	CC
cord-022313-2675sjlf	39	13	(	(	-LRB-
cord-022313-2675sjlf	39	14	2	2	LS
cord-022313-2675sjlf	39	15	)	)	-RRB-
cord-022313-2675sjlf	39	16	one	one	PRP
cord-022313-2675sjlf	39	17	must	must	MD
cord-022313-2675sjlf	39	18	make	make	VB
cord-022313-2675sjlf	39	19	the	the	DT
cord-022313-2675sjlf	39	20	assumption	assumption	NN
cord-022313-2675sjlf	39	21	that	that	IN
cord-022313-2675sjlf	39	22	the	the	DT
cord-022313-2675sjlf	39	23	change	change	NN
cord-022313-2675sjlf	39	24	in	in	IN
cord-022313-2675sjlf	39	25	the	the	DT
cord-022313-2675sjlf	39	26	amino	amino	NN
cord-022313-2675sjlf	39	27	acid	acid	NN
cord-022313-2675sjlf	39	28	sequence	sequence	NN
cord-022313-2675sjlf	39	29	does	do	VBZ
cord-022313-2675sjlf	39	30	not	not	RB
cord-022313-2675sjlf	39	31	itself	-PRON-	PRP
cord-022313-2675sjlf	39	32	affect	affect	VB
cord-022313-2675sjlf	39	33	protein	protein	NN
cord-022313-2675sjlf	39	34	conformation	conformation	NN
cord-022313-2675sjlf	39	35	.	.	.
cord-022313-2675sjlf	40	1	This	this	DT
cord-022313-2675sjlf	40	2	methodol	methodol	NN
cord-022313-2675sjlf	40	3	ogy	ogy	NNP
cord-022313-2675sjlf	40	4	has	have	VBZ
cord-022313-2675sjlf	40	5	provided	provide	VBN
cord-022313-2675sjlf	40	6	some	some	DT
cord-022313-2675sjlf	40	7	valuable	valuable	JJ
cord-022313-2675sjlf	40	8	insights	insight	NNS
cord-022313-2675sjlf	40	9	into	into	IN
cord-022313-2675sjlf	40	10	the	the	DT
cord-022313-2675sjlf	40	11	role	role	NN
cord-022313-2675sjlf	40	12	of	of	IN
cord-022313-2675sjlf	40	13	asparaginelinked	asparaginelinked	JJ
cord-022313-2675sjlf	40	14	glycosylation	glycosylation	NN
cord-022313-2675sjlf	40	15	.	.	.
cord-022313-2675sjlf	41	1	However	however	RB
cord-022313-2675sjlf	41	2	,	,	,
cord-022313-2675sjlf	41	3	if	if	IN
cord-022313-2675sjlf	41	4	all	all	DT
cord-022313-2675sjlf	41	5	N	n	CD
cord-022313-2675sjlf	41	6	-	-	HYPH
cord-022313-2675sjlf	41	7	linked	link	VBN
cord-022313-2675sjlf	41	8	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	41	9	sequons	sequon	NNS
cord-022313-2675sjlf	41	10	are	be	VBP
cord-022313-2675sjlf	41	11	modified	modify	VBN
cord-022313-2675sjlf	41	12	,	,	,
cord-022313-2675sjlf	41	13	then	then	RB
cord-022313-2675sjlf	41	14	the	the	DT
cord-022313-2675sjlf	41	15	same	same	JJ
cord-022313-2675sjlf	41	16	problem	problem	NN
cord-022313-2675sjlf	41	17	of	of	IN
cord-022313-2675sjlf	41	18	improper	improper	JJ
cord-022313-2675sjlf	41	19	folding	folding	NN
cord-022313-2675sjlf	41	20	or	or	CC
cord-022313-2675sjlf	41	21	solubility	solubility	NN
cord-022313-2675sjlf	41	22	that	that	WDT
cord-022313-2675sjlf	41	23	one	one	PRP
cord-022313-2675sjlf	41	24	finds	find	VBZ
cord-022313-2675sjlf	41	25	with	with	IN
cord-022313-2675sjlf	41	26	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	41	27	would	would	MD
cord-022313-2675sjlf	41	28	also	also	RB
cord-022313-2675sjlf	41	29	apply	apply	VB
cord-022313-2675sjlf	41	30	here	here	RB
cord-022313-2675sjlf	41	31	.	.	.
cord-022313-2675sjlf	42	1	Another	another	DT
cord-022313-2675sjlf	42	2	possi	possi	NN
cord-022313-2675sjlf	42	3	bility	bility	NN
cord-022313-2675sjlf	42	4	is	be	VBZ
cord-022313-2675sjlf	42	5	to	to	TO
cord-022313-2675sjlf	42	6	modify	modify	VB
cord-022313-2675sjlf	42	7	glycosylation	glycosylation	NN
cord-022313-2675sjlf	42	8	rather	rather	RB
cord-022313-2675sjlf	42	9	than	than	IN
cord-022313-2675sjlf	42	10	prevent	prevent	VB
cord-022313-2675sjlf	42	11	it	-PRON-	PRP
cord-022313-2675sjlf	42	12	,	,	,
cord-022313-2675sjlf	42	13	so	so	IN
cord-022313-2675sjlf	42	14	that	that	IN
cord-022313-2675sjlf	42	15	the	the	DT
cord-022313-2675sjlf	42	16	resulting	result	VBG
cord-022313-2675sjlf	42	17	N	n	CD
cord-022313-2675sjlf	42	18	-	-	HYPH
cord-022313-2675sjlf	42	19	linked	link	VBN
cord-022313-2675sjlf	42	20	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	42	21	contains	contain	VBZ
cord-022313-2675sjlf	42	22	an	an	DT
cord-022313-2675sjlf	42	23	altered	altered	JJ
cord-022313-2675sjlf	42	24	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	42	25	structure	structure	NN
cord-022313-2675sjlf	42	26	.	.	.
cord-022313-2675sjlf	43	1	One	one	PRP
cord-022313-2675sjlf	43	2	can	can	MD
cord-022313-2675sjlf	43	3	then	then	RB
cord-022313-2675sjlf	43	4	determine	determine	VB
cord-022313-2675sjlf	43	5	if	if	IN
cord-022313-2675sjlf	43	6	and	and	CC
cord-022313-2675sjlf	43	7	how	how	WRB
cord-022313-2675sjlf	43	8	this	this	DT
cord-022313-2675sjlf	43	9	alteration	alteration	NN
cord-022313-2675sjlf	43	10	affects	affect	VBZ
cord-022313-2675sjlf	43	11	the	the	DT
cord-022313-2675sjlf	43	12	biological	biological	JJ
cord-022313-2675sjlf	43	13	activity	activity	NN
cord-022313-2675sjlf	43	14	of	of	IN
cord-022313-2675sjlf	43	15	a	a	DT
cord-022313-2675sjlf	43	16	given	give	VBN
cord-022313-2675sjlf	43	17	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	43	18	.	.	.
cord-022313-2675sjlf	44	1	There	there	EX
cord-022313-2675sjlf	44	2	are	be	VBP
cord-022313-2675sjlf	44	3	several	several	JJ
cord-022313-2675sjlf	44	4	ways	way	NNS
cord-022313-2675sjlf	44	5	to	to	TO
cord-022313-2675sjlf	44	6	modify	modify	VB
cord-022313-2675sjlf	44	7	N	n	CD
cord-022313-2675sjlf	44	8	-	-	HYPH
cord-022313-2675sjlf	44	9	linked	link	VBN
cord-022313-2675sjlf	44	10	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	44	11	structures	structure	NNS
cord-022313-2675sjlf	44	12	.	.	.
cord-022313-2675sjlf	45	1	For	for	IN
cord-022313-2675sjlf	45	2	example	example	NN
cord-022313-2675sjlf	45	3	,	,	,
cord-022313-2675sjlf	45	4	the	the	DT
cord-022313-2675sjlf	45	5	protein	protein	NN
cord-022313-2675sjlf	45	6	of	of	IN
cord-022313-2675sjlf	45	7	interest	interest	NN
cord-022313-2675sjlf	45	8	can	can	MD
cord-022313-2675sjlf	45	9	be	be	VB
cord-022313-2675sjlf	45	10	produced	produce	VBN
cord-022313-2675sjlf	45	11	in	in	IN
cord-022313-2675sjlf	45	12	a	a	DT
cord-022313-2675sjlf	45	13	mutant	mutant	JJ
cord-022313-2675sjlf	45	14	cell	cell	NN
cord-022313-2675sjlf	45	15	line	line	NN
cord-022313-2675sjlf	45	16	that	that	WDT
cord-022313-2675sjlf	45	17	has	have	VBZ
cord-022313-2675sjlf	45	18	a	a	DT
cord-022313-2675sjlf	45	19	defect	defect	NN
cord-022313-2675sjlf	45	20	in	in	IN
cord-022313-2675sjlf	45	21	one	one	CD
cord-022313-2675sjlf	45	22	of	of	IN
cord-022313-2675sjlf	45	23	the	the	DT
cord-022313-2675sjlf	45	24	biosynthetic	biosynthetic	JJ
cord-022313-2675sjlf	45	25	enzymes	enzyme	NNS
cord-022313-2675sjlf	45	26	.	.	.
cord-022313-2675sjlf	46	1	Cell	cell	NN
cord-022313-2675sjlf	46	2	lines	line	NNS
cord-022313-2675sjlf	46	3	that	that	WDT
cord-022313-2675sjlf	46	4	are	be	VBP
cord-022313-2675sjlf	46	5	missing	miss	VBG
cord-022313-2675sjlf	46	6	various	various	JJ
cord-022313-2675sjlf	46	7	glycosyltransferases	glycosyltransferase	NNS
cord-022313-2675sjlf	46	8	or	or	CC
cord-022313-2675sjlf	46	9	processing	processing	NN
cord-022313-2675sjlf	46	10	glycosidases	glycosidase	NNS
cord-022313-2675sjlf	46	11	have	have	VBP
cord-022313-2675sjlf	46	12	been	be	VBN
cord-022313-2675sjlf	46	13	isolated	isolate	VBN
cord-022313-2675sjlf	46	14	,	,	,
cord-022313-2675sjlf	46	15	and	and	CC
cord-022313-2675sjlf	46	16	several	several	JJ
cord-022313-2675sjlf	46	17	excellent	excellent	JJ
cord-022313-2675sjlf	46	18	reviews	review	NNS
cord-022313-2675sjlf	46	19	have	have	VBP
cord-022313-2675sjlf	46	20	described	describe	VBN
cord-022313-2675sjlf	46	21	the	the	DT
cord-022313-2675sjlf	46	22	various	various	JJ
cord-022313-2675sjlf	46	23	mutants	mutant	NNS
cord-022313-2675sjlf	46	24	and	and	CC
cord-022313-2675sjlf	46	25	the	the	DT
cord-022313-2675sjlf	46	26	techniques	technique	NNS
cord-022313-2675sjlf	46	27	for	for	IN
cord-022313-2675sjlf	46	28	their	-PRON-	PRP$
cord-022313-2675sjlf	46	29	utilization	utilization	NN
cord-022313-2675sjlf	46	30	(	(	-LRB-
cord-022313-2675sjlf	46	31	25	25	CD
cord-022313-2675sjlf	46	32	,	,	,
cord-022313-2675sjlf	46	33	26	26	CD
cord-022313-2675sjlf	46	34	)	)	-RRB-
cord-022313-2675sjlf	46	35	.	.	.
cord-022313-2675sjlf	47	1	In	in	IN
cord-022313-2675sjlf	47	2	this	this	DT
cord-022313-2675sjlf	47	3	case	case	NN
cord-022313-2675sjlf	47	4	also	also	RB
cord-022313-2675sjlf	47	5	,	,	,
cord-022313-2675sjlf	47	6	one	one	PRP
cord-022313-2675sjlf	47	7	must	must	MD
cord-022313-2675sjlf	47	8	have	have	VB
cord-022313-2675sjlf	47	9	the	the	DT
cord-022313-2675sjlf	47	10	gene	gene	NN
cord-022313-2675sjlf	47	11	for	for	IN
cord-022313-2675sjlf	47	12	the	the	DT
cord-022313-2675sjlf	47	13	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	47	14	of	of	IN
cord-022313-2675sjlf	47	15	interest	interest	NN
cord-022313-2675sjlf	47	16	in	in	IN
cord-022313-2675sjlf	47	17	order	order	NN
cord-022313-2675sjlf	47	18	to	to	TO
cord-022313-2675sjlf	47	19	introduce	introduce	VB
cord-022313-2675sjlf	47	20	it	-PRON-	PRP
cord-022313-2675sjlf	47	21	into	into	IN
cord-022313-2675sjlf	47	22	the	the	DT
cord-022313-2675sjlf	47	23	mutant	mutant	JJ
cord-022313-2675sjlf	47	24	cell	cell	NN
cord-022313-2675sjlf	47	25	line	line	NN
cord-022313-2675sjlf	47	26	for	for	IN
cord-022313-2675sjlf	47	27	synthesis	synthesis	NN
cord-022313-2675sjlf	47	28	of	of	IN
cord-022313-2675sjlf	47	29	the	the	DT
cord-022313-2675sjlf	47	30	appropriate	appropriate	JJ
cord-022313-2675sjlf	47	31	protein	protein	NN
cord-022313-2675sjlf	47	32	.	.	.
cord-022313-2675sjlf	48	1	The	the	DT
cord-022313-2675sjlf	48	2	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	48	3	structure	structure	NN
cord-022313-2675sjlf	48	4	can	can	MD
cord-022313-2675sjlf	48	5	also	also	RB
cord-022313-2675sjlf	48	6	be	be	VB
cord-022313-2675sjlf	48	7	modified	modify	VBN
cord-022313-2675sjlf	48	8	with	with	IN
cord-022313-2675sjlf	48	9	selected	select	VBN
cord-022313-2675sjlf	48	10	inhibi	inhibi	NNP
cord-022313-2675sjlf	48	11	tors	tor	NNS
cord-022313-2675sjlf	48	12	that	that	WDT
cord-022313-2675sjlf	48	13	block	block	VBP
cord-022313-2675sjlf	48	14	the	the	DT
cord-022313-2675sjlf	48	15	activity	activity	NN
cord-022313-2675sjlf	48	16	of	of	IN
cord-022313-2675sjlf	48	17	key	key	JJ
cord-022313-2675sjlf	48	18	enzymes	enzyme	NNS
cord-022313-2675sjlf	48	19	in	in	IN
cord-022313-2675sjlf	48	20	the	the	DT
cord-022313-2675sjlf	48	21	processing	processing	NN
cord-022313-2675sjlf	48	22	pathway	pathway	NN
cord-022313-2675sjlf	48	23	,	,	,
cord-022313-2675sjlf	48	24	so	so	IN
cord-022313-2675sjlf	48	25	that	that	IN
cord-022313-2675sjlf	48	26	synthesis	synthesis	NN
cord-022313-2675sjlf	48	27	is	be	VBZ
cord-022313-2675sjlf	48	28	stopped	stop	VBN
cord-022313-2675sjlf	48	29	at	at	IN
cord-022313-2675sjlf	48	30	a	a	DT
cord-022313-2675sjlf	48	31	premature	premature	JJ
cord-022313-2675sjlf	48	32	step	step	NN
cord-022313-2675sjlf	48	33	and	and	CC
cord-022313-2675sjlf	48	34	the	the	DT
cord-022313-2675sjlf	48	35	various	various	JJ
cord-022313-2675sjlf	48	36	types	type	NNS
cord-022313-2675sjlf	48	37	of	of	IN
cord-022313-2675sjlf	48	38	complex	complex	JJ
cord-022313-2675sjlf	48	39	chains	chain	NNS
cord-022313-2675sjlf	48	40	can	can	MD
cord-022313-2675sjlf	48	41	not	not	RB
cord-022313-2675sjlf	48	42	be	be	VB
cord-022313-2675sjlf	48	43	formed	form	VBN
cord-022313-2675sjlf	48	44	.	.	.
cord-022313-2675sjlf	49	1	Such	such	JJ
cord-022313-2675sjlf	49	2	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	49	3	and	and	CC
cord-022313-2675sjlf	49	4	their	-PRON-	PRP$
cord-022313-2675sjlf	49	5	sites	site	NNS
cord-022313-2675sjlf	49	6	of	of	IN
cord-022313-2675sjlf	49	7	action	action	NN
cord-022313-2675sjlf	49	8	are	be	VBP
cord-022313-2675sjlf	49	9	the	the	DT
cord-022313-2675sjlf	49	10	main	main	JJ
cord-022313-2675sjlf	49	11	topics	topic	NNS
cord-022313-2675sjlf	49	12	of	of	IN
cord-022313-2675sjlf	49	13	this	this	DT
cord-022313-2675sjlf	49	14	chapter	chapter	NN
cord-022313-2675sjlf	49	15	.	.	.
cord-022313-2675sjlf	50	1	One	one	CD
cord-022313-2675sjlf	50	2	disadvantage	disadvantage	NN
cord-022313-2675sjlf	50	3	on	on	IN
cord-022313-2675sjlf	50	4	the	the	DT
cord-022313-2675sjlf	50	5	use	use	NN
cord-022313-2675sjlf	50	6	of	of	IN
cord-022313-2675sjlf	50	7	such	such	JJ
cord-022313-2675sjlf	50	8	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	50	9	in	in	IN
cord-022313-2675sjlf	50	10	in	in	IN
cord-022313-2675sjlf	50	11	vivo	vivo	NN
cord-022313-2675sjlf	50	12	studies	study	NNS
cord-022313-2675sjlf	50	13	is	be	VBZ
cord-022313-2675sjlf	50	14	that	that	IN
cord-022313-2675sjlf	50	15	all	all	DT
cord-022313-2675sjlf	50	16	N	n	NN
cord-022313-2675sjlf	50	17	-	-	HYPH
cord-022313-2675sjlf	50	18	linked	link	VBN
cord-022313-2675sjlf	50	19	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	50	20	are	be	VBP
cord-022313-2675sjlf	50	21	affected	affect	VBN
cord-022313-2675sjlf	50	22	,	,	,
cord-022313-2675sjlf	50	23	and	and	CC
cord-022313-2675sjlf	50	24	therefore	therefore	RB
cord-022313-2675sjlf	50	25	it	-PRON-	PRP
cord-022313-2675sjlf	50	26	may	may	MD
cord-022313-2675sjlf	50	27	be	be	VB
cord-022313-2675sjlf	50	28	difficult	difficult	JJ
cord-022313-2675sjlf	50	29	to	to	TO
cord-022313-2675sjlf	50	30	relate	relate	VB
cord-022313-2675sjlf	50	31	changes	change	NNS
cord-022313-2675sjlf	50	32	in	in	IN
cord-022313-2675sjlf	50	33	physiology	physiology	NN
cord-022313-2675sjlf	50	34	to	to	IN
cord-022313-2675sjlf	50	35	an	an	DT
cord-022313-2675sjlf	50	36	effect	effect	NN
cord-022313-2675sjlf	50	37	on	on	IN
cord-022313-2675sjlf	50	38	the	the	DT
cord-022313-2675sjlf	50	39	specific	specific	JJ
cord-022313-2675sjlf	50	40	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	50	41	of	of	IN
cord-022313-2675sjlf	50	42	interest	interest	NN
cord-022313-2675sjlf	50	43	.	.	.
cord-022313-2675sjlf	51	1	In	in	IN
cord-022313-2675sjlf	51	2	fact	fact	NN
cord-022313-2675sjlf	51	3	,	,	,
cord-022313-2675sjlf	51	4	one	one	CD
cord-022313-2675sjlf	51	5	criticism	criticism	NN
cord-022313-2675sjlf	51	6	that	that	WDT
cord-022313-2675sjlf	51	7	can	can	MD
cord-022313-2675sjlf	51	8	be	be	VB
cord-022313-2675sjlf	51	9	levied	levy	VBN
cord-022313-2675sjlf	51	10	at	at	IN
cord-022313-2675sjlf	51	11	the	the	DT
cord-022313-2675sjlf	51	12	use	use	NN
cord-022313-2675sjlf	51	13	of	of	IN
cord-022313-2675sjlf	51	14	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	51	15	in	in	IN
cord-022313-2675sjlf	51	16	most	most	JJS
cord-022313-2675sjlf	51	17	biological	biological	JJ
cord-022313-2675sjlf	51	18	systems	system	NNS
cord-022313-2675sjlf	51	19	(	(	-LRB-
cord-022313-2675sjlf	51	20	and	and	CC
cord-022313-2675sjlf	51	21	also	also	RB
cord-022313-2675sjlf	51	22	as	as	IN
cord-022313-2675sjlf	51	23	chemotherapeutic	chemotherapeutic	JJ
cord-022313-2675sjlf	51	24	agents	agent	NNS
cord-022313-2675sjlf	51	25	)	)	-RRB-
cord-022313-2675sjlf	51	26	is	be	VBZ
cord-022313-2675sjlf	51	27	that	that	DT
cord-022313-2675sjlf	51	28	absolute	absolute	JJ
cord-022313-2675sjlf	51	29	specific	specific	JJ
cord-022313-2675sjlf	51	30	ity	ity	NN
cord-022313-2675sjlf	51	31	is	be	VBZ
cord-022313-2675sjlf	51	32	seldom	seldom	RB
cord-022313-2675sjlf	51	33	if	if	IN
cord-022313-2675sjlf	51	34	ever	ever	RB
cord-022313-2675sjlf	51	35	achieved	achieve	VBN
cord-022313-2675sjlf	51	36	.	.	.
cord-022313-2675sjlf	52	1	Of	of	RB
cord-022313-2675sjlf	52	2	course	course	RB
cord-022313-2675sjlf	52	3	in	in	IN
cord-022313-2675sjlf	52	4	the	the	DT
cord-022313-2675sjlf	52	5	above	above	JJ
cord-022313-2675sjlf	52	6	case	case	NN
cord-022313-2675sjlf	52	7	,	,	,
cord-022313-2675sjlf	52	8	if	if	IN
cord-022313-2675sjlf	52	9	the	the	DT
cord-022313-2675sjlf	52	10	altered	altered	JJ
cord-022313-2675sjlf	52	11	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	52	12	can	can	MD
cord-022313-2675sjlf	52	13	be	be	VB
cord-022313-2675sjlf	52	14	isolated	isolate	VBN
cord-022313-2675sjlf	52	15	from	from	IN
cord-022313-2675sjlf	52	16	the	the	DT
cord-022313-2675sjlf	52	17	inhibited	inhibited	JJ
cord-022313-2675sjlf	52	18	(	(	-LRB-
cord-022313-2675sjlf	52	19	or	or	CC
cord-022313-2675sjlf	52	20	mutated	mutate	VBN
cord-022313-2675sjlf	52	21	)	)	-RRB-
cord-022313-2675sjlf	52	22	cell	cell	NN
cord-022313-2675sjlf	52	23	and	and	CC
cord-022313-2675sjlf	52	24	its	-PRON-	PRP$
cord-022313-2675sjlf	52	25	activity	activity	NN
cord-022313-2675sjlf	52	26	compared	compare	VBN
cord-022313-2675sjlf	52	27	with	with	IN
cord-022313-2675sjlf	52	28	the	the	DT
cord-022313-2675sjlf	52	29	normal	normal	JJ
cord-022313-2675sjlf	52	30	protein	protein	NN
cord-022313-2675sjlf	52	31	,	,	,
cord-022313-2675sjlf	52	32	either	either	CC
cord-022313-2675sjlf	52	33	in	in	IN
cord-022313-2675sjlf	52	34	vitro	vitro	FW
cord-022313-2675sjlf	52	35	or	or	CC
cord-022313-2675sjlf	52	36	in	in	IN
cord-022313-2675sjlf	52	37	another	another	DT
cord-022313-2675sjlf	52	38	system	system	NN
cord-022313-2675sjlf	52	39	,	,	,
cord-022313-2675sjlf	52	40	then	then	RB
cord-022313-2675sjlf	52	41	this	this	DT
cord-022313-2675sjlf	52	42	criticism	criticism	NN
cord-022313-2675sjlf	52	43	can	can	MD
cord-022313-2675sjlf	52	44	be	be	VB
cord-022313-2675sjlf	52	45	overcome	overcome	VBN
cord-022313-2675sjlf	52	46	.	.	.
cord-022313-2675sjlf	53	1	One	one	CD
cord-022313-2675sjlf	53	2	final	final	JJ
cord-022313-2675sjlf	53	3	method	method	NN
cord-022313-2675sjlf	53	4	for	for	IN
cord-022313-2675sjlf	53	5	altering	alter	VBG
cord-022313-2675sjlf	53	6	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	53	7	structure	structure	NN
cord-022313-2675sjlf	53	8	is	be	VBZ
cord-022313-2675sjlf	53	9	to	to	TO
cord-022313-2675sjlf	53	10	disrupt	disrupt	VB
cord-022313-2675sjlf	53	11	or	or	CC
cord-022313-2675sjlf	53	12	alter	alter	VB
cord-022313-2675sjlf	53	13	the	the	DT
cord-022313-2675sjlf	53	14	normal	normal	JJ
cord-022313-2675sjlf	53	15	transport	transport	NN
cord-022313-2675sjlf	53	16	of	of	IN
cord-022313-2675sjlf	53	17	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	53	18	from	from	IN
cord-022313-2675sjlf	53	19	the	the	DT
cord-022313-2675sjlf	53	20	ER	ER	NNP
cord-022313-2675sjlf	53	21	through	through	IN
cord-022313-2675sjlf	53	22	the	the	DT
cord-022313-2675sjlf	53	23	various	various	JJ
cord-022313-2675sjlf	53	24	Golgi	Golgi	NNP
cord-022313-2675sjlf	53	25	stacks	stack	NNS
cord-022313-2675sjlf	53	26	to	to	IN
cord-022313-2675sjlf	53	27	their	-PRON-	PRP$
cord-022313-2675sjlf	53	28	ultimate	ultimate	JJ
cord-022313-2675sjlf	53	29	location	location	NN
cord-022313-2675sjlf	53	30	.	.	.
cord-022313-2675sjlf	54	1	Since	since	IN
cord-022313-2675sjlf	54	2	it	-PRON-	PRP
cord-022313-2675sjlf	54	3	is	be	VBZ
cord-022313-2675sjlf	54	4	now	now	RB
cord-022313-2675sjlf	54	5	clear	clear	JJ
cord-022313-2675sjlf	54	6	that	that	IN
cord-022313-2675sjlf	54	7	certain	certain	JJ
cord-022313-2675sjlf	54	8	of	of	IN
cord-022313-2675sjlf	54	9	the	the	DT
cord-022313-2675sjlf	54	10	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	54	11	trimming	trim	VBG
cord-022313-2675sjlf	54	12	reactions	reaction	NNS
cord-022313-2675sjlf	54	13	occur	occur	VBP
cord-022313-2675sjlf	54	14	in	in	IN
cord-022313-2675sjlf	54	15	the	the	DT
cord-022313-2675sjlf	54	16	ER	ER	NNP
cord-022313-2675sjlf	54	17	,	,	,
cord-022313-2675sjlf	54	18	whereas	whereas	IN
cord-022313-2675sjlf	54	19	others	other	NNS
cord-022313-2675sjlf	54	20	occur	occur	VBP
cord-022313-2675sjlf	54	21	in	in	IN
cord-022313-2675sjlf	54	22	the	the	DT
cord-022313-2675sjlf	54	23	cis	cis	NNP
cord-022313-2675sjlf	54	24	-	-	HYPH
cord-022313-2675sjlf	54	25	Golgi	Golgi	NNP
cord-022313-2675sjlf	54	26	and	and	CC
cord-022313-2675sjlf	54	27	still	still	RB
cord-022313-2675sjlf	54	28	others	other	NNS
cord-022313-2675sjlf	54	29	in	in	IN
cord-022313-2675sjlf	54	30	the	the	DT
cord-022313-2675sjlf	54	31	medial	medial	JJ
cord-022313-2675sjlf	54	32	Golgi	Golgi	NNP
cord-022313-2675sjlf	54	33	,	,	,
cord-022313-2675sjlf	54	34	etc	etc	FW
cord-022313-2675sjlf	54	35	.	.	FW
cord-022313-2675sjlf	54	36	,	,	,
cord-022313-2675sjlf	54	37	the	the	DT
cord-022313-2675sjlf	54	38	basis	basis	NN
cord-022313-2675sjlf	54	39	of	of	IN
cord-022313-2675sjlf	54	40	this	this	DT
cord-022313-2675sjlf	54	41	approach	approach	NN
cord-022313-2675sjlf	54	42	is	be	VBZ
cord-022313-2675sjlf	54	43	to	to	TO
cord-022313-2675sjlf	54	44	prevent	prevent	VB
cord-022313-2675sjlf	54	45	the	the	DT
cord-022313-2675sjlf	54	46	protein	protein	NN
cord-022313-2675sjlf	54	47	from	from	IN
cord-022313-2675sjlf	54	48	being	be	VBG
cord-022313-2675sjlf	54	49	transported	transport	VBN
cord-022313-2675sjlf	54	50	to	to	IN
cord-022313-2675sjlf	54	51	that	that	DT
cord-022313-2675sjlf	54	52	region	region	NN
cord-022313-2675sjlf	54	53	where	where	WRB
cord-022313-2675sjlf	54	54	the	the	DT
cord-022313-2675sjlf	54	55	enzymatic	enzymatic	JJ
cord-022313-2675sjlf	54	56	activity	activity	NN
cord-022313-2675sjlf	54	57	is	be	VBZ
cord-022313-2675sjlf	54	58	located	locate	VBN
cord-022313-2675sjlf	54	59	.	.	.
cord-022313-2675sjlf	55	1	If	if	IN
cord-022313-2675sjlf	55	2	one	one	PRP
cord-022313-2675sjlf	55	3	can	can	MD
cord-022313-2675sjlf	55	4	somehow	somehow	RB
cord-022313-2675sjlf	55	5	prevent	prevent	VB
cord-022313-2675sjlf	55	6	the	the	DT
cord-022313-2675sjlf	55	7	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	55	8	from	from	IN
cord-022313-2675sjlf	55	9	reaching	reach	VBG
cord-022313-2675sjlf	55	10	the	the	DT
cord-022313-2675sjlf	55	11	specific	specific	JJ
cord-022313-2675sjlf	55	12	compartment	compartment	NN
cord-022313-2675sjlf	55	13	that	that	WDT
cord-022313-2675sjlf	55	14	houses	house	VBZ
cord-022313-2675sjlf	55	15	that	that	DT
cord-022313-2675sjlf	55	16	activity	activity	NN
cord-022313-2675sjlf	55	17	,	,	,
cord-022313-2675sjlf	55	18	then	then	RB
cord-022313-2675sjlf	55	19	that	that	DT
cord-022313-2675sjlf	55	20	reaction	reaction	NN
cord-022313-2675sjlf	55	21	should	should	MD
cord-022313-2675sjlf	55	22	not	not	RB
cord-022313-2675sjlf	55	23	occur	occur	VB
cord-022313-2675sjlf	55	24	.	.	.
cord-022313-2675sjlf	56	1	There	there	EX
cord-022313-2675sjlf	56	2	are	be	VBP
cord-022313-2675sjlf	56	3	several	several	JJ
cord-022313-2675sjlf	56	4	valuable	valuable	JJ
cord-022313-2675sjlf	56	5	compounds	compound	NNS
cord-022313-2675sjlf	56	6	that	that	WDT
cord-022313-2675sjlf	56	7	have	have	VBP
cord-022313-2675sjlf	56	8	such	such	JJ
cord-022313-2675sjlf	56	9	properties	property	NNS
cord-022313-2675sjlf	56	10	and	and	CC
cord-022313-2675sjlf	56	11	these	these	DT
cord-022313-2675sjlf	56	12	drugs	drug	NNS
cord-022313-2675sjlf	56	13	will	will	MD
cord-022313-2675sjlf	56	14	be	be	VB
cord-022313-2675sjlf	56	15	discussed	discuss	VBN
cord-022313-2675sjlf	56	16	in	in	IN
cord-022313-2675sjlf	56	17	a	a	DT
cord-022313-2675sjlf	56	18	later	later	JJ
cord-022313-2675sjlf	56	19	section	section	NN
cord-022313-2675sjlf	56	20	.	.	.
cord-022313-2675sjlf	57	1	These	these	DT
cord-022313-2675sjlf	57	2	types	type	NNS
cord-022313-2675sjlf	57	3	of	of	IN
cord-022313-2675sjlf	57	4	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	57	5	have	have	VBP
cord-022313-2675sjlf	57	6	been	be	VBN
cord-022313-2675sjlf	57	7	extremely	extremely	RB
cord-022313-2675sjlf	57	8	useful	useful	JJ
cord-022313-2675sjlf	57	9	tools	tool	NNS
cord-022313-2675sjlf	57	10	for	for	IN
cord-022313-2675sjlf	57	11	helping	help	VBG
cord-022313-2675sjlf	57	12	us	-PRON-	PRP
cord-022313-2675sjlf	57	13	to	to	TO
cord-022313-2675sjlf	57	14	understand	understand	VB
cord-022313-2675sjlf	57	15	the	the	DT
cord-022313-2675sjlf	57	16	mechanism(s	mechanism(s	NNP
cord-022313-2675sjlf	57	17	)	)	-RRB-
cord-022313-2675sjlf	57	18	of	of	IN
cord-022313-2675sjlf	57	19	protein	protein	NN
cord-022313-2675sjlf	57	20	targeting	targeting	NN
cord-022313-2675sjlf	57	21	.	.	.
cord-022313-2675sjlf	58	1	In	in	IN
cord-022313-2675sjlf	58	2	terms	term	NNS
cord-022313-2675sjlf	58	3	of	of	IN
cord-022313-2675sjlf	58	4	the	the	DT
cord-022313-2675sjlf	58	5	glycan	glycan	NN
cord-022313-2675sjlf	58	6	portion	portion	NN
cord-022313-2675sjlf	58	7	of	of	IN
cord-022313-2675sjlf	58	8	the	the	DT
cord-022313-2675sjlf	58	9	GPI	GPI	NNP
cord-022313-2675sjlf	58	10	anchor	anchor	NN
cord-022313-2675sjlf	58	11	,	,	,
cord-022313-2675sjlf	58	12	a	a	DT
cord-022313-2675sjlf	58	13	number	number	NN
cord-022313-2675sjlf	58	14	of	of	IN
cord-022313-2675sjlf	58	15	recent	recent	JJ
cord-022313-2675sjlf	58	16	studies	study	NNS
cord-022313-2675sjlf	58	17	have	have	VBP
cord-022313-2675sjlf	58	18	demonstrated	demonstrate	VBN
cord-022313-2675sjlf	58	19	that	that	IN
cord-022313-2675sjlf	58	20	various	various	JJ
cord-022313-2675sjlf	58	21	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	58	22	that	that	WDT
cord-022313-2675sjlf	58	23	act	act	VBP
cord-022313-2675sjlf	58	24	on	on	IN
cord-022313-2675sjlf	58	25	the	the	DT
cord-022313-2675sjlf	58	26	re	re	NN
cord-022313-2675sjlf	58	27	linked	link	VBN
cord-022313-2675sjlf	58	28	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	58	29	also	also	RB
cord-022313-2675sjlf	58	30	inhibit	inhibit	VBP
cord-022313-2675sjlf	58	31	some	some	DT
cord-022313-2675sjlf	58	32	of	of	IN
cord-022313-2675sjlf	58	33	the	the	DT
cord-022313-2675sjlf	58	34	reactions	reaction	NNS
cord-022313-2675sjlf	58	35	in	in	IN
cord-022313-2675sjlf	58	36	anchor	anchor	NN
cord-022313-2675sjlf	58	37	formation	formation	NN
cord-022313-2675sjlf	58	38	.	.	.
cord-022313-2675sjlf	59	1	These	these	DT
cord-022313-2675sjlf	59	2	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	59	3	are	be	VBP
cord-022313-2675sjlf	59	4	providing	provide	VBG
cord-022313-2675sjlf	59	5	useful	useful	JJ
cord-022313-2675sjlf	59	6	information	information	NN
cord-022313-2675sjlf	59	7	on	on	IN
cord-022313-2675sjlf	59	8	the	the	DT
cord-022313-2675sjlf	59	9	biosynthetic	biosynthetic	JJ
cord-022313-2675sjlf	59	10	pathway	pathway	NN
cord-022313-2675sjlf	59	11	and	and	CC
cord-022313-2675sjlf	59	12	should	should	MD
cord-022313-2675sjlf	59	13	also	also	RB
cord-022313-2675sjlf	59	14	be	be	VB
cord-022313-2675sjlf	59	15	helpful	helpful	JJ
cord-022313-2675sjlf	59	16	for	for	IN
cord-022313-2675sjlf	59	17	functional	functional	JJ
cord-022313-2675sjlf	59	18	studies	study	NNS
cord-022313-2675sjlf	59	19	.	.	.
cord-022313-2675sjlf	60	1	However	however	RB
cord-022313-2675sjlf	60	2	,	,	,
cord-022313-2675sjlf	60	3	at	at	IN
cord-022313-2675sjlf	60	4	this	this	DT
cord-022313-2675sjlf	60	5	stage	stage	NN
cord-022313-2675sjlf	60	6	,	,	,
cord-022313-2675sjlf	60	7	we	-PRON-	PRP
cord-022313-2675sjlf	60	8	still	still	RB
cord-022313-2675sjlf	60	9	do	do	VBP
cord-022313-2675sjlf	60	10	not	not	RB
cord-022313-2675sjlf	60	11	know	know	VB
cord-022313-2675sjlf	60	12	enough	enough	JJ
cord-022313-2675sjlf	60	13	about	about	IN
cord-022313-2675sjlf	60	14	the	the	DT
cord-022313-2675sjlf	60	15	synthesis	synthesis	NN
cord-022313-2675sjlf	60	16	of	of	IN
cord-022313-2675sjlf	60	17	the	the	DT
cord-022313-2675sjlf	60	18	glycan	glycan	NN
cord-022313-2675sjlf	60	19	portion	portion	NN
cord-022313-2675sjlf	60	20	of	of	IN
cord-022313-2675sjlf	60	21	the	the	DT
cord-022313-2675sjlf	60	22	GPI	GPI	NNP
cord-022313-2675sjlf	60	23	anchors	anchor	NNS
cord-022313-2675sjlf	60	24	,	,	,
cord-022313-2675sjlf	60	25	nor	nor	CC
cord-022313-2675sjlf	60	26	do	do	VBP
cord-022313-2675sjlf	60	27	we	-PRON-	PRP
cord-022313-2675sjlf	60	28	really	really	RB
cord-022313-2675sjlf	60	29	understand	understand	VB
cord-022313-2675sjlf	60	30	their	-PRON-	PRP$
cord-022313-2675sjlf	60	31	function	function	NN
cord-022313-2675sjlf	60	32	.	.	.
cord-022313-2675sjlf	61	1	This	this	DT
cord-022313-2675sjlf	61	2	chapter	chapter	NN
cord-022313-2675sjlf	61	3	will	will	MD
cord-022313-2675sjlf	61	4	deal	deal	VB
cord-022313-2675sjlf	61	5	with	with	IN
cord-022313-2675sjlf	61	6	various	various	JJ
cord-022313-2675sjlf	61	7	types	type	NNS
cord-022313-2675sjlf	61	8	of	of	IN
cord-022313-2675sjlf	61	9	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	61	10	that	that	WDT
cord-022313-2675sjlf	61	11	affect	affect	VBP
cord-022313-2675sjlf	61	12	GPI	GPI	NNP
cord-022313-2675sjlf	61	13	anchor	anchor	NN
cord-022313-2675sjlf	61	14	formation	formation	NN
cord-022313-2675sjlf	61	15	,	,	,
cord-022313-2675sjlf	61	16	as	as	RB
cord-022313-2675sjlf	61	17	well	well	RB
cord-022313-2675sjlf	61	18	as	as	IN
cord-022313-2675sjlf	61	19	those	those	DT
cord-022313-2675sjlf	61	20	that	that	WDT
cord-022313-2675sjlf	61	21	act	act	VBP
cord-022313-2675sjlf	61	22	on	on	IN
cord-022313-2675sjlf	61	23	the	the	DT
cord-022313-2675sjlf	61	24	re	re	NN
cord-022313-2675sjlf	61	25	linked	link	VBN
cord-022313-2675sjlf	61	26	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	61	27	.	.	.
cord-022313-2675sjlf	62	1	II	II	NNP
cord-022313-2675sjlf	62	2	.	.	.
cord-022313-2675sjlf	63	1	The	the	DT
cord-022313-2675sjlf	63	2	most	most	RBS
cord-022313-2675sjlf	63	3	common	common	JJ
cord-022313-2675sjlf	63	4	types	type	NNS
cord-022313-2675sjlf	63	5	of	of	IN
cord-022313-2675sjlf	63	6	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	63	7	that	that	WDT
cord-022313-2675sjlf	63	8	are	be	VBP
cord-022313-2675sjlf	63	9	present	present	JJ
cord-022313-2675sjlf	63	10	in	in	IN
cord-022313-2675sjlf	63	11	eucaryotic	eucaryotic	JJ
cord-022313-2675sjlf	63	12	cells	cell	NNS
cord-022313-2675sjlf	63	13	,	,	,
cord-022313-2675sjlf	63	14	as	as	IN
cord-022313-2675sjlf	63	15	cell	cell	NN
cord-022313-2675sjlf	63	16	surface	surface	NN
cord-022313-2675sjlf	63	17	proteins	protein	NNS
cord-022313-2675sjlf	63	18	,	,	,
cord-022313-2675sjlf	63	19	membrane	membrane	NN
cord-022313-2675sjlf	63	20	proteins	protein	NNS
cord-022313-2675sjlf	63	21	,	,	,
cord-022313-2675sjlf	63	22	and	and	CC
cord-022313-2675sjlf	63	23	secretory	secretory	NN
cord-022313-2675sjlf	63	24	proteins	protein	NNS
cord-022313-2675sjlf	63	25	,	,	,
cord-022313-2675sjlf	63	26	are	be	VBP
cord-022313-2675sjlf	63	27	those	those	DT
cord-022313-2675sjlf	63	28	having	have	VBG
cord-022313-2675sjlf	63	29	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	63	30	attached	attach	VBN
cord-022313-2675sjlf	63	31	to	to	IN
cord-022313-2675sjlf	63	32	the	the	DT
cord-022313-2675sjlf	63	33	amide	amide	NN
cord-022313-2675sjlf	63	34	nitro	nitro	NNP
cord-022313-2675sjlf	63	35	gen	gen	NN
cord-022313-2675sjlf	63	36	of	of	IN
cord-022313-2675sjlf	63	37	asparagine	asparagine	NNP
cord-022313-2675sjlf	63	38	(	(	-LRB-
cord-022313-2675sjlf	63	39	N	n	NN
cord-022313-2675sjlf	63	40	-	-	HYPH
cord-022313-2675sjlf	63	41	linked	link	VBN
cord-022313-2675sjlf	63	42	or	or	CC
cord-022313-2675sjlf	63	43	asparagine	asparagine	NN
cord-022313-2675sjlf	63	44	-	-	HYPH
cord-022313-2675sjlf	63	45	linked	link	VBN
cord-022313-2675sjlf	63	46	)	)	-RRB-
cord-022313-2675sjlf	63	47	(	(	-LRB-
cord-022313-2675sjlf	63	48	10	10	CD
cord-022313-2675sjlf	63	49	)	)	-RRB-
cord-022313-2675sjlf	63	50	.	.	.
cord-022313-2675sjlf	64	1	The	the	DT
cord-022313-2675sjlf	64	2	oligosac	oligosac	NNP
cord-022313-2675sjlf	64	3	charide	charide	NN
cord-022313-2675sjlf	64	4	portion	portion	NN
cord-022313-2675sjlf	64	5	of	of	IN
cord-022313-2675sjlf	64	6	these	these	DT
cord-022313-2675sjlf	64	7	molecules	molecule	NNS
cord-022313-2675sjlf	64	8	may	may	MD
cord-022313-2675sjlf	64	9	have	have	VB
cord-022313-2675sjlf	64	10	a	a	DT
cord-022313-2675sjlf	64	11	variety	variety	NN
cord-022313-2675sjlf	64	12	of	of	IN
cord-022313-2675sjlf	64	13	different	different	JJ
cord-022313-2675sjlf	64	14	structures	structure	NNS
cord-022313-2675sjlf	64	15	that	that	WDT
cord-022313-2675sjlf	64	16	fall	fall	VBP
cord-022313-2675sjlf	64	17	into	into	IN
cord-022313-2675sjlf	64	18	one	one	CD
cord-022313-2675sjlf	64	19	of	of	IN
cord-022313-2675sjlf	64	20	the	the	DT
cord-022313-2675sjlf	64	21	general	general	JJ
cord-022313-2675sjlf	64	22	groups	group	NNS
cord-022313-2675sjlf	64	23	shown	show	VBN
cord-022313-2675sjlf	64	24	in	in	IN
cord-022313-2675sjlf	64	25	Fig	Fig	NNP
cord-022313-2675sjlf	64	26	.	.	.
cord-022313-2675sjlf	65	1	1	1	LS
cord-022313-2675sjlf	65	2	.	.	.
cord-022313-2675sjlf	66	1	These	these	DT
cord-022313-2675sjlf	66	2	are	be	VBP
cord-022313-2675sjlf	66	3	referred	refer	VBN
cord-022313-2675sjlf	66	4	to	to	IN
cord-022313-2675sjlf	66	5	as	as	RB
cord-022313-2675sjlf	66	6	high	high	JJ
cord-022313-2675sjlf	66	7	-	-	HYPH
cord-022313-2675sjlf	66	8	mannose	mannose	NN
cord-022313-2675sjlf	66	9	,	,	,
cord-022313-2675sjlf	66	10	complex	complex	JJ
cord-022313-2675sjlf	66	11	,	,	,
cord-022313-2675sjlf	66	12	or	or	CC
cord-022313-2675sjlf	66	13	hybrid	hybrid	JJ
cord-022313-2675sjlf	66	14	types	type	NNS
cord-022313-2675sjlf	66	15	of	of	IN
cord-022313-2675sjlf	66	16	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	66	17	.	.	.
cord-022313-2675sjlf	67	1	It	-PRON-	PRP
cord-022313-2675sjlf	67	2	can	can	MD
cord-022313-2675sjlf	67	3	be	be	VB
cord-022313-2675sjlf	67	4	seen	see	VBN
cord-022313-2675sjlf	67	5	from	from	IN
cord-022313-2675sjlf	67	6	the	the	DT
cord-022313-2675sjlf	67	7	figure	figure	NN
cord-022313-2675sjlf	67	8	that	that	IN
cord-022313-2675sjlf	67	9	each	each	DT
cord-022313-2675sjlf	67	10	of	of	IN
cord-022313-2675sjlf	67	11	these	these	DT
cord-022313-2675sjlf	67	12	structures	structure	NNS
cord-022313-2675sjlf	67	13	contains	contain	VBZ
cord-022313-2675sjlf	67	14	the	the	DT
cord-022313-2675sjlf	67	15	same	same	JJ
cord-022313-2675sjlf	67	16	basic	basic	JJ
cord-022313-2675sjlf	67	17	core	core	NN
cord-022313-2675sjlf	67	18	region	region	NN
cord-022313-2675sjlf	67	19	(	(	-LRB-
cord-022313-2675sjlf	67	20	shown	show	VBN
cord-022313-2675sjlf	67	21	by	by	IN
cord-022313-2675sjlf	67	22	the	the	DT
cord-022313-2675sjlf	67	23	boxed	box	VBN
cord-022313-2675sjlf	67	24	-	-	HYPH
cord-022313-2675sjlf	67	25	in	in	RP
cord-022313-2675sjlf	67	26	area	area	NN
cord-022313-2675sjlf	67	27	)	)	-RRB-
cord-022313-2675sjlf	67	28	composed	compose	VBN
cord-022313-2675sjlf	67	29	of	of	IN
cord-022313-2675sjlf	67	30	the	the	DT
cord-022313-2675sjlf	67	31	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	67	32	sequence	sequence	NN
cord-022313-2675sjlf	67	33	Manal,6(Manal,3	Manal,6(Manal,3	NNP
cord-022313-2675sjlf	67	34	)	)	-RRB-
cord-022313-2675sjlf	67	35	Man)31,4GlcNAcj81,4GlcNAc	Man)31,4GlcNAcj81,4GlcNAc	NNP
cord-022313-2675sjlf	67	36	.	.	.
cord-022313-2675sjlf	68	1	In	in	IN
cord-022313-2675sjlf	68	2	the	the	DT
cord-022313-2675sjlf	68	3	high	high	JJ
cord-022313-2675sjlf	68	4	-	-	HYPH
cord-022313-2675sjlf	68	5	mannose	mannose	NN
cord-022313-2675sjlf	68	6	structures	structure	NNS
cord-022313-2675sjlf	68	7	,	,	,
cord-022313-2675sjlf	68	8	this	this	DT
cord-022313-2675sjlf	68	9	core	core	NN
cord-022313-2675sjlf	68	10	region	region	NN
cord-022313-2675sjlf	68	11	is	be	VBZ
cord-022313-2675sjlf	68	12	elongated	elongate	VBN
cord-022313-2675sjlf	68	13	by	by	IN
cord-022313-2675sjlf	68	14	as	as	RB
cord-022313-2675sjlf	68	15	many	many	JJ
cord-022313-2675sjlf	68	16	as	as	IN
cord-022313-2675sjlf	68	17	six	six	CD
cord-022313-2675sjlf	68	18	additional	additional	JJ
cord-022313-2675sjlf	68	19	mannose	mannose	NN
cord-022313-2675sjlf	68	20	residues	residue	NNS
cord-022313-2675sjlf	68	21	(	(	-LRB-
cord-022313-2675sjlf	68	22	i.e.	i.e.	FW
cord-022313-2675sjlf	68	23	,	,	,
cord-022313-2675sjlf	68	24	a	a	DT
cord-022313-2675sjlf	68	25	total	total	NN
cord-022313-2675sjlf	68	26	of	of	IN
cord-022313-2675sjlf	68	27	nine	nine	CD
cord-022313-2675sjlf	68	28	mannose	mannose	JJ
cord-022313-2675sjlf	68	29	units	unit	NNS
cord-022313-2675sjlf	68	30	)	)	-RRB-
cord-022313-2675sjlf	68	31	attached	attach	VBN
cord-022313-2675sjlf	68	32	in	in	IN
cord-022313-2675sjlf	68	33	al,2	al,2	NNP
cord-022313-2675sjlf	68	34	,	,	,
cord-022313-2675sjlf	68	35	al,3	al,3	NNP
cord-022313-2675sjlf	68	36	,	,	,
cord-022313-2675sjlf	68	37	and	and	CC
cord-022313-2675sjlf	68	38	al,6	al,6	NNP
cord-022313-2675sjlf	68	39	linkages	linkage	NNS
cord-022313-2675sjlf	68	40	,	,	,
cord-022313-2675sjlf	68	41	as	as	IN
cord-022313-2675sjlf	68	42	shown	show	VBN
cord-022313-2675sjlf	68	43	by	by	IN
cord-022313-2675sjlf	68	44	the	the	DT
cord-022313-2675sjlf	68	45	typical	typical	JJ
cord-022313-2675sjlf	68	46	structure	structure	NN
cord-022313-2675sjlf	68	47	presented	present	VBN
cord-022313-2675sjlf	68	48	in	in	IN
cord-022313-2675sjlf	68	49	Fig	Fig	NNP
cord-022313-2675sjlf	68	50	.	.	.
cord-022313-2675sjlf	69	1	1	1	LS
cord-022313-2675sjlf	69	2	.	.	.
cord-022313-2675sjlf	70	1	However	however	RB
cord-022313-2675sjlf	70	2	,	,	,
cord-022313-2675sjlf	70	3	some	some	DT
cord-022313-2675sjlf	70	4	high	high	JJ
cord-022313-2675sjlf	70	5	-	-	HYPH
cord-022313-2675sjlf	70	6	mannose	mannose	NN
cord-022313-2675sjlf	70	7	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	70	8	may	may	MD
cord-022313-2675sjlf	70	9	have	have	VB
cord-022313-2675sjlf	70	10	fewer	few	JJR
cord-022313-2675sjlf	70	11	than	than	IN
cord-022313-2675sjlf	70	12	six	six	CD
cord-022313-2675sjlf	70	13	additional	additional	JJ
cord-022313-2675sjlf	70	14	mannoses	mannose	NNS
cord-022313-2675sjlf	70	15	,	,	,
cord-022313-2675sjlf	70	16	since	since	IN
cord-022313-2675sjlf	70	17	some	some	DT
cord-022313-2675sjlf	70	18	trimming	trimming	NN
cord-022313-2675sjlf	70	19	can	can	MD
cord-022313-2675sjlf	70	20	occur	occur	VB
cord-022313-2675sjlf	70	21	during	during	IN
cord-022313-2675sjlf	70	22	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	70	23	(	(	-LRB-
cord-022313-2675sjlf	70	24	see	see	VB
cord-022313-2675sjlf	70	25	Section	section	NN
cord-022313-2675sjlf	70	26	V	v	NN
cord-022313-2675sjlf	70	27	)	)	-RRB-
cord-022313-2675sjlf	70	28	.	.	.
cord-022313-2675sjlf	71	1	On	on	IN
cord-022313-2675sjlf	71	2	the	the	DT
cord-022313-2675sjlf	71	3	other	other	JJ
cord-022313-2675sjlf	71	4	hand	hand	NN
cord-022313-2675sjlf	71	5	,	,	,
cord-022313-2675sjlf	71	6	in	in	IN
cord-022313-2675sjlf	71	7	the	the	DT
cord-022313-2675sjlf	71	8	complex	complex	JJ
cord-022313-2675sjlf	71	9	types	type	NNS
cord-022313-2675sjlf	71	10	of	of	IN
cord-022313-2675sjlf	71	11	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	71	12	,	,	,
cord-022313-2675sjlf	71	13	the	the	DT
cord-022313-2675sjlf	71	14	pentasaccharide	pentasaccharide	NNP
cord-022313-2675sjlf	71	15	core	core	NN
cord-022313-2675sjlf	71	16	region	region	NN
cord-022313-2675sjlf	71	17	can	can	MD
cord-022313-2675sjlf	71	18	be	be	VB
cord-022313-2675sjlf	71	19	extended	extend	VBN
cord-022313-2675sjlf	71	20	with	with	IN
cord-022313-2675sjlf	71	21	a	a	DT
cord-022313-2675sjlf	71	22	number	number	NN
cord-022313-2675sjlf	71	23	of	of	IN
cord-022313-2675sjlf	71	24	different	different	JJ
cord-022313-2675sjlf	71	25	substitutions	substitution	NNS
cord-022313-2675sjlf	71	26	.	.	.
cord-022313-2675sjlf	72	1	Shown	show	VBN
cord-022313-2675sjlf	72	2	in	in	IN
cord-022313-2675sjlf	72	3	the	the	DT
cord-022313-2675sjlf	72	4	figure	figure	NN
cord-022313-2675sjlf	72	5	is	be	VBZ
cord-022313-2675sjlf	72	6	a	a	DT
cord-022313-2675sjlf	72	7	typical	typical	JJ
cord-022313-2675sjlf	72	8	biantennary	biantennary	JJ
cord-022313-2675sjlf	72	9	type	type	NN
cord-022313-2675sjlf	72	10	of	of	IN
cord-022313-2675sjlf	72	11	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	72	12	,	,	,
cord-022313-2675sjlf	72	13	containing	contain	VBG
cord-022313-2675sjlf	72	14	two	two	CD
cord-022313-2675sjlf	72	15	of	of	IN
cord-022313-2675sjlf	72	16	the	the	DT
cord-022313-2675sjlf	72	17	trisaccharide	trisaccharide	NNP
cord-022313-2675sjlf	72	18	sequences	sequence	NNS
cord-022313-2675sjlf	72	19	,	,	,
cord-022313-2675sjlf	72	20	NeuAca2,6Gal/31,4GlcNAc/31,2	NeuAca2,6Gal/31,4GlcNAc/31,2	NNP
cord-022313-2675sjlf	72	21	.	.	.
cord-022313-2675sjlf	73	1	On	on	IN
cord-022313-2675sjlf	73	2	the	the	DT
cord-022313-2675sjlf	73	3	other	other	JJ
cord-022313-2675sjlf	73	4	hand	hand	NN
cord-022313-2675sjlf	73	5	,	,	,
cord-022313-2675sjlf	73	6	some	some	DT
cord-022313-2675sjlf	73	7	complex	complex	JJ
cord-022313-2675sjlf	73	8	chains	chain	NNS
cord-022313-2675sjlf	73	9	may	may	MD
cord-022313-2675sjlf	73	10	have	have	VB
cord-022313-2675sjlf	73	11	three	three	CD
cord-022313-2675sjlf	73	12	(	(	-LRB-
cord-022313-2675sjlf	73	13	triantennary	triantennary	NNP
cord-022313-2675sjlf	73	14	)	)	-RRB-
cord-022313-2675sjlf	73	15	or	or	CC
cord-022313-2675sjlf	73	16	four	four	CD
cord-022313-2675sjlf	73	17	(	(	-LRB-
cord-022313-2675sjlf	73	18	tetraantennary	tetraantennary	NNP
cord-022313-2675sjlf	73	19	)	)	-RRB-
cord-022313-2675sjlf	73	20	of	of	IN
cord-022313-2675sjlf	73	21	these	these	DT
cord-022313-2675sjlf	73	22	trisaccharide	trisaccharide	NNP
cord-022313-2675sjlf	73	23	sequences	sequence	NNS
cord-022313-2675sjlf	73	24	,	,	,
cord-022313-2675sjlf	73	25	as	as	RB
cord-022313-2675sjlf	73	26	well	well	RB
cord-022313-2675sjlf	73	27	as	as	IN
cord-022313-2675sjlf	73	28	various	various	JJ
cord-022313-2675sjlf	73	29	other	other	JJ
cord-022313-2675sjlf	73	30	substitutions	substitution	NNS
cord-022313-2675sjlf	73	31	such	such	JJ
cord-022313-2675sjlf	73	32	as	as	IN
cord-022313-2675sjlf	73	33	al,6-linked	al,6-linked	NNP
cord-022313-2675sjlf	73	34	L	L	NNP
cord-022313-2675sjlf	73	35	-	-	HYPH
cord-022313-2675sjlf	73	36	fucose	fucose	NNP
cord-022313-2675sjlf	73	37	on	on	IN
cord-022313-2675sjlf	73	38	the	the	DT
cord-022313-2675sjlf	73	39	innermost	innermost	JJ
cord-022313-2675sjlf	73	40	GlcNAc	glcnac	NN
cord-022313-2675sjlf	73	41	or	or	CC
cord-022313-2675sjlf	73	42	sulfate	sulfate	NN
cord-022313-2675sjlf	73	43	residues	residue	NNS
cord-022313-2675sjlf	73	44	attached	attach	VBN
cord-022313-2675sjlf	73	45	to	to	IN
cord-022313-2675sjlf	73	46	this	this	DT
cord-022313-2675sjlf	73	47	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	73	48	(	(	-LRB-
cord-022313-2675sjlf	73	49	10	10	CD
cord-022313-2675sjlf	73	50	)	)	-RRB-
cord-022313-2675sjlf	73	51	.	.	.
cord-022313-2675sjlf	74	1	Various	various	JJ
cord-022313-2675sjlf	74	2	other	other	JJ
cord-022313-2675sjlf	74	3	alterations	alteration	NNS
cord-022313-2675sjlf	74	4	may	may	MD
cord-022313-2675sjlf	74	5	also	also	RB
cord-022313-2675sjlf	74	6	occur	occur	VB
cord-022313-2675sjlf	74	7	,	,	,
cord-022313-2675sjlf	74	8	such	such	JJ
cord-022313-2675sjlf	74	9	as	as	IN
cord-022313-2675sjlf	74	10	al,3-linked	al,3-linked	JJ
cord-022313-2675sjlf	74	11	fucose	fucose	JJ
cord-022313-2675sjlf	74	12	units	unit	NNS
cord-022313-2675sjlf	74	13	on	on	IN
cord-022313-2675sjlf	74	14	the	the	DT
cord-022313-2675sjlf	74	15	outer	outer	JJ
cord-022313-2675sjlf	74	16	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	74	17	residues	residue	NNS
cord-022313-2675sjlf	74	18	,	,	,
cord-022313-2675sjlf	74	19	polylactosamine	polylactosamine	NNP
cord-022313-2675sjlf	74	20	chains	chain	NNS
cord-022313-2675sjlf	74	21	,	,	,
cord-022313-2675sjlf	74	22	a	a	DT
cord-022313-2675sjlf	74	23	/31,4-bisecting	/31,4-bisecting	NNP
cord-022313-2675sjlf	74	24	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	74	25	residue	residue	NN
cord-022313-2675sjlf	74	26	attached	attach	VBN
cord-022313-2675sjlf	74	27	to	to	IN
cord-022313-2675sjlf	74	28	the	the	DT
cord-022313-2675sjlf	74	29	βlinked	βlinked	JJ
cord-022313-2675sjlf	74	30	mannose	mannose	NN
cord-022313-2675sjlf	74	31	and	and	CC
cord-022313-2675sjlf	74	32	so	so	RB
cord-022313-2675sjlf	74	33	on	on	RB
cord-022313-2675sjlf	74	34	,	,	,
cord-022313-2675sjlf	74	35	as	as	RB
cord-022313-2675sjlf	74	36	well	well	RB
cord-022313-2675sjlf	74	37	as	as	IN
cord-022313-2675sjlf	74	38	various	various	JJ
cord-022313-2675sjlf	74	39	glycosidic	glycosidic	JJ
cord-022313-2675sjlf	74	40	linkages	linkage	NNS
cord-022313-2675sjlf	74	41	such	such	JJ
cord-022313-2675sjlf	74	42	as	as	IN
cord-022313-2675sjlf	74	43	a2,3-linked	a2,3-linked	CD
cord-022313-2675sjlf	74	44	sialic	sialic	NN
cord-022313-2675sjlf	74	45	acid	acid	NN
cord-022313-2675sjlf	74	46	rather	rather	RB
cord-022313-2675sjlf	74	47	than	than	IN
cord-022313-2675sjlf	74	48	a2,6-linked	a2,6-linked	CD
cord-022313-2675sjlf	74	49	sialic	sialic	JJ
cord-022313-2675sjlf	74	50	acid	acid	NN
cord-022313-2675sjlf	74	51	,	,	,
cord-022313-2675sjlf	74	52	etc	etc	FW
cord-022313-2675sjlf	74	53	.	.	.
cord-022313-2675sjlf	75	1	Al	Al	NNP
cord-022313-2675sjlf	75	2	-	-	:
cord-022313-2675sjlf	75	3	though	though	IN
cord-022313-2675sjlf	75	4	the	the	DT
cord-022313-2675sjlf	75	5	exact	exact	JJ
cord-022313-2675sjlf	75	6	number	number	NN
cord-022313-2675sjlf	75	7	of	of	IN
cord-022313-2675sjlf	75	8	different	different	JJ
cord-022313-2675sjlf	75	9	types	type	NNS
cord-022313-2675sjlf	75	10	of	of	IN
cord-022313-2675sjlf	75	11	complex	complex	JJ
cord-022313-2675sjlf	75	12	chains	chain	NNS
cord-022313-2675sjlf	75	13	is	be	VBZ
cord-022313-2675sjlf	75	14	not	not	RB
cord-022313-2675sjlf	75	15	clear	clear	JJ
cord-022313-2675sjlf	75	16	,	,	,
cord-022313-2675sjlf	75	17	it	-PRON-	PRP
cord-022313-2675sjlf	75	18	has	have	VBZ
cord-022313-2675sjlf	75	19	been	be	VBN
cord-022313-2675sjlf	75	20	estimated	estimate	VBN
cord-022313-2675sjlf	75	21	that	that	IN
cord-022313-2675sjlf	75	22	there	there	EX
cord-022313-2675sjlf	75	23	are	be	VBP
cord-022313-2675sjlf	75	24	probably	probably	RB
cord-022313-2675sjlf	75	25	several	several	JJ
cord-022313-2675sjlf	75	26	hundred	hundred	CD
cord-022313-2675sjlf	75	27	known	know	VBN
cord-022313-2675sjlf	75	28	structures	structure	NNS
cord-022313-2675sjlf	75	29	(	(	-LRB-
cord-022313-2675sjlf	75	30	27	27	CD
cord-022313-2675sjlf	75	31	)	)	-RRB-
cord-022313-2675sjlf	75	32	.	.	.
cord-022313-2675sjlf	76	1	The	the	DT
cord-022313-2675sjlf	76	2	final	final	JJ
cord-022313-2675sjlf	76	3	type	type	NN
cord-022313-2675sjlf	76	4	of	of	IN
cord-022313-2675sjlf	76	5	N	n	NN
cord-022313-2675sjlf	76	6	-	-	HYPH
cord-022313-2675sjlf	76	7	linked	link	VBN
cord-022313-2675sjlf	76	8	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	76	9	is	be	VBZ
cord-022313-2675sjlf	76	10	the	the	DT
cord-022313-2675sjlf	76	11	hybrid	hybrid	JJ
cord-022313-2675sjlf	76	12	structure	structure	NN
cord-022313-2675sjlf	76	13	,	,	,
cord-022313-2675sjlf	76	14	which	which	WDT
cord-022313-2675sjlf	76	15	still	still	RB
cord-022313-2675sjlf	76	16	contains	contain	VBZ
cord-022313-2675sjlf	76	17	a	a	DT
cord-022313-2675sjlf	76	18	Manal,6	manal,6	NN
cord-022313-2675sjlf	76	19	(	(	-LRB-
cord-022313-2675sjlf	76	20	Manexl,3	Manexl,3	NNP
cord-022313-2675sjlf	76	21	)	)	-RRB-
cord-022313-2675sjlf	76	22	branch	branch	NN
cord-022313-2675sjlf	76	23	on	on	IN
cord-022313-2675sjlf	76	24	the	the	DT
cord-022313-2675sjlf	76	25	al,6-mannose	al,6-mannose	JJ
cord-022313-2675sjlf	76	26	arm	arm	NN
cord-022313-2675sjlf	76	27	,	,	,
cord-022313-2675sjlf	76	28	but	but	CC
cord-022313-2675sjlf	76	29	also	also	RB
cord-022313-2675sjlf	76	30	has	have	VBZ
cord-022313-2675sjlf	76	31	a	a	DT
cord-022313-2675sjlf	76	32	type	type	NN
cord-022313-2675sjlf	76	33	of	of	IN
cord-022313-2675sjlf	76	34	complex	complex	JJ
cord-022313-2675sjlf	76	35	chain	chain	NN
cord-022313-2675sjlf	76	36	on	on	IN
cord-022313-2675sjlf	76	37	the	the	DT
cord-022313-2675sjlf	76	38	al,3-branch	al,3-branch	NNP
cord-022313-2675sjlf	76	39	.	.	.
cord-022313-2675sjlf	77	1	Most	Most	JJS
cord-022313-2675sjlf	77	2	hybrid	hybrid	JJ
cord-022313-2675sjlf	77	3	chains	chain	NNS
cord-022313-2675sjlf	77	4	also	also	RB
cord-022313-2675sjlf	77	5	apparantly	apparantly	RB
cord-022313-2675sjlf	77	6	have	have	VBP
cord-022313-2675sjlf	77	7	a	a	DT
cord-022313-2675sjlf	77	8	bisecting	bisect	VBG
cord-022313-2675sjlf	77	9	GlcNAc	glcnac	NN
cord-022313-2675sjlf	77	10	attached	attach	VBN
cord-022313-2675sjlf	77	11	in	in	IN
cord-022313-2675sjlf	77	12	/31,4-linkage	/31,4-linkage	NN
cord-022313-2675sjlf	77	13	to	to	IN
cord-022313-2675sjlf	77	14	the	the	DT
cord-022313-2675sjlf	77	15	β	β	NN
cord-022313-2675sjlf	77	16	-	-	HYPH
cord-022313-2675sjlf	77	17	linked	link	VBN
cord-022313-2675sjlf	77	18	mannose	mannose	NN
cord-022313-2675sjlf	77	19	,	,	,
cord-022313-2675sjlf	77	20	and	and	CC
cord-022313-2675sjlf	77	21	this	this	DT
cord-022313-2675sjlf	77	22	substitution	substitution	NN
cord-022313-2675sjlf	77	23	may	may	MD
cord-022313-2675sjlf	77	24	play	play	VB
cord-022313-2675sjlf	77	25	a	a	DT
cord-022313-2675sjlf	77	26	role	role	NN
cord-022313-2675sjlf	77	27	in	in	IN
cord-022313-2675sjlf	77	28	the	the	DT
cord-022313-2675sjlf	77	29	control	control	NN
cord-022313-2675sjlf	77	30	of	of	IN
cord-022313-2675sjlf	77	31	further	further	JJ
cord-022313-2675sjlf	77	32	processing	processing	NN
cord-022313-2675sjlf	77	33	reactions	reaction	NNS
cord-022313-2675sjlf	77	34	.	.	.
cord-022313-2675sjlf	78	1	The	the	DT
cord-022313-2675sjlf	78	2	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	78	3	of	of	IN
cord-022313-2675sjlf	78	4	all	all	DT
cord-022313-2675sjlf	78	5	of	of	IN
cord-022313-2675sjlf	78	6	these	these	DT
cord-022313-2675sjlf	78	7	N	n	NN
cord-022313-2675sjlf	78	8	-	-	HYPH
cord-022313-2675sjlf	78	9	linked	link	VBN
cord-022313-2675sjlf	78	10	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	78	11	involves	involve	VBZ
cord-022313-2675sjlf	78	12	two	two	CD
cord-022313-2675sjlf	78	13	independent	independent	JJ
cord-022313-2675sjlf	78	14	and	and	CC
cord-022313-2675sjlf	78	15	sequential	sequential	JJ
cord-022313-2675sjlf	78	16	pathways	pathway	NNS
cord-022313-2675sjlf	78	17	that	that	WDT
cord-022313-2675sjlf	78	18	occur	occur	VBP
cord-022313-2675sjlf	78	19	in	in	IN
cord-022313-2675sjlf	78	20	the	the	DT
cord-022313-2675sjlf	78	21	endo	endo	NN
cord-022313-2675sjlf	78	22	plasmic	plasmic	JJ
cord-022313-2675sjlf	78	23	reticulum	reticulum	NN
cord-022313-2675sjlf	78	24	(	(	-LRB-
cord-022313-2675sjlf	78	25	ER	ER	NNP
cord-022313-2675sjlf	78	26	)	)	-RRB-
cord-022313-2675sjlf	78	27	and	and	CC
cord-022313-2675sjlf	78	28	Golgi	Golgi	NNP
cord-022313-2675sjlf	78	29	apparatus	apparatus	NN
cord-022313-2675sjlf	78	30	of	of	IN
cord-022313-2675sjlf	78	31	the	the	DT
cord-022313-2675sjlf	78	32	cell	cell	NN
cord-022313-2675sjlf	78	33	.	.	.
cord-022313-2675sjlf	79	1	In	in	IN
cord-022313-2675sjlf	79	2	the	the	DT
cord-022313-2675sjlf	79	3	first	first	JJ
cord-022313-2675sjlf	79	4	series	series	NN
cord-022313-2675sjlf	79	5	of	of	IN
cord-022313-2675sjlf	79	6	reactions	reaction	NNS
cord-022313-2675sjlf	79	7	,	,	,
cord-022313-2675sjlf	79	8	membrane	membrane	NN
cord-022313-2675sjlf	79	9	and	and	CC
cord-022313-2675sjlf	79	10	secretory	secretory	NN
cord-022313-2675sjlf	79	11	proteins	protein	NNS
cord-022313-2675sjlf	79	12	that	that	WDT
cord-022313-2675sjlf	79	13	are	be	VBP
cord-022313-2675sjlf	79	14	under	under	IN
cord-022313-2675sjlf	79	15	going	go	VBG
cord-022313-2675sjlf	79	16	synthesis	synthesis	NN
cord-022313-2675sjlf	79	17	on	on	IN
cord-022313-2675sjlf	79	18	membrane	membrane	NN
cord-022313-2675sjlf	79	19	-	-	HYPH
cord-022313-2675sjlf	79	20	bound	bind	VBN
cord-022313-2675sjlf	79	21	polysomes	polysome	NNS
cord-022313-2675sjlf	79	22	become	become	VBP
cord-022313-2675sjlf	79	23	glycosy	glycosy	NN
cord-022313-2675sjlf	79	24	lated	late	VBN
cord-022313-2675sjlf	79	25	by	by	IN
cord-022313-2675sjlf	79	26	transfer	transfer	NN
cord-022313-2675sjlf	79	27	of	of	IN
cord-022313-2675sjlf	79	28	a	a	DT
cord-022313-2675sjlf	79	29	common	common	JJ
cord-022313-2675sjlf	79	30	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	79	31	having	have	VBG
cord-022313-2675sjlf	79	32	the	the	DT
cord-022313-2675sjlf	79	33	structure	structure	NN
cord-022313-2675sjlf	80	1	Glc	Glc	NNP
cord-022313-2675sjlf	80	2	3	3	CD
cord-022313-2675sjlf	80	3	Man	Man	NNP
cord-022313-2675sjlf	80	4	9	9	CD
cord-022313-2675sjlf	80	5	(	(	-LRB-
cord-022313-2675sjlf	80	6	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	80	7	)	)	-RRB-
cord-022313-2675sjlf	80	8	2	2	CD
cord-022313-2675sjlf	80	9	from	from	IN
cord-022313-2675sjlf	80	10	its	-PRON-	PRP$
cord-022313-2675sjlf	80	11	lipid	lipid	NN
cord-022313-2675sjlf	80	12	-	-	HYPH
cord-022313-2675sjlf	80	13	linked	link	VBN
cord-022313-2675sjlf	80	14	saccharide	saccharide	NN
cord-022313-2675sjlf	80	15	form	form	NN
cord-022313-2675sjlf	80	16	,	,	,
cord-022313-2675sjlf	80	17	i.e.	i.e.	FW
cord-022313-2675sjlf	80	18	,	,	,
cord-022313-2675sjlf	80	19	Glc	Glc	NNP
cord-022313-2675sjlf	80	20	3	3	CD
cord-022313-2675sjlf	80	21	Man	Man	NNP
cord-022313-2675sjlf	80	22	9	9	CD
cord-022313-2675sjlf	80	23	(	(	-LRB-
cord-022313-2675sjlf	80	24	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	80	25	)	)	-RRB-
cord-022313-2675sjlf	80	26	2	2	CD
cord-022313-2675sjlf	80	27	-PP	-PP	NNS
cord-022313-2675sjlf	80	28	-	-	HYPH
cord-022313-2675sjlf	80	29	dolichol	dolichol	JJ
cord-022313-2675sjlf	80	30	,	,	,
cord-022313-2675sjlf	80	31	to	to	IN
cord-022313-2675sjlf	80	32	specific	specific	JJ
cord-022313-2675sjlf	80	33	-Asn	-asn	JJ
cord-022313-2675sjlf	80	34	-	-	HYPH
cord-022313-2675sjlf	80	35	X	x	NN
cord-022313-2675sjlf	80	36	-	-	JJ
cord-022313-2675sjlf	80	37	Ser	ser	JJ
cord-022313-2675sjlf	81	1	(	(	-LRB-
cord-022313-2675sjlf	81	2	Thr)-sequences	thr)-sequence	NNS
cord-022313-2675sjlf	81	3	on	on	IN
cord-022313-2675sjlf	81	4	the	the	DT
cord-022313-2675sjlf	81	5	protein	protein	NN
cord-022313-2675sjlf	81	6	(	(	-LRB-
cord-022313-2675sjlf	81	7	28	28	CD
cord-022313-2675sjlf	81	8	)	)	-RRB-
cord-022313-2675sjlf	81	9	.	.	.
cord-022313-2675sjlf	82	1	This	this	DT
cord-022313-2675sjlf	82	2	pathway	pathway	NN
cord-022313-2675sjlf	82	3	is	be	VBZ
cord-022313-2675sjlf	82	4	referred	refer	VBN
cord-022313-2675sjlf	82	5	to	to	IN
cord-022313-2675sjlf	82	6	as	as	IN
cord-022313-2675sjlf	82	7	the	the	DT
cord-022313-2675sjlf	82	8	"	"	``
cord-022313-2675sjlf	82	9	dolichol	dolichol	JJ
cord-022313-2675sjlf	82	10	cycle	cycle	NN
cord-022313-2675sjlf	82	11	"	"	''
cord-022313-2675sjlf	82	12	and	and	CC
cord-022313-2675sjlf	82	13	is	be	VBZ
cord-022313-2675sjlf	82	14	depicted	depict	VBN
cord-022313-2675sjlf	82	15	in	in	IN
cord-022313-2675sjlf	82	16	Fig	Fig	NNP
cord-022313-2675sjlf	82	17	.	.	.
cord-022313-2675sjlf	83	1	2	2	LS
cord-022313-2675sjlf	83	2	.	.	.
cord-022313-2675sjlf	84	1	A	a	DT
cord-022313-2675sjlf	84	2	series	series	NN
cord-022313-2675sjlf	84	3	of	of	IN
cord-022313-2675sjlf	84	4	glycosyltransferases	glycosyltransferase	NNS
cord-022313-2675sjlf	84	5	that	that	WDT
cord-022313-2675sjlf	84	6	are	be	VBP
cord-022313-2675sjlf	84	7	associated	associate	VBN
cord-022313-2675sjlf	84	8	with	with	IN
cord-022313-2675sjlf	84	9	the	the	DT
cord-022313-2675sjlf	84	10	ER	ER	NNP
cord-022313-2675sjlf	84	11	membrane	membrane	NN
cord-022313-2675sjlf	84	12	sequentially	sequentially	RB
cord-022313-2675sjlf	84	13	add	add	VBP
cord-022313-2675sjlf	84	14	the	the	DT
cord-022313-2675sjlf	84	15	sugars	sugar	NNS
cord-022313-2675sjlf	84	16	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	84	17	,	,	,
cord-022313-2675sjlf	84	18	mannose	mannose	NN
cord-022313-2675sjlf	84	19	,	,	,
cord-022313-2675sjlf	84	20	and	and	CC
cord-022313-2675sjlf	84	21	glucose	glucose	NN
cord-022313-2675sjlf	84	22	to	to	IN
cord-022313-2675sjlf	84	23	the	the	DT
cord-022313-2675sjlf	84	24	lipid	lipid	NN
cord-022313-2675sjlf	84	25	carrier	carrier	NN
cord-022313-2675sjlf	84	26	dolichyl	dolichyl	NN
cord-022313-2675sjlf	84	27	-	-	HYPH
cord-022313-2675sjlf	84	28	P	p	NN
cord-022313-2675sjlf	84	29	to	to	TO
cord-022313-2675sjlf	84	30	give	give	VB
cord-022313-2675sjlf	84	31	the	the	DT
cord-022313-2675sjlf	84	32	above	above	RB
cord-022313-2675sjlf	84	33	-	-	HYPH
cord-022313-2675sjlf	84	34	mentioned	mention	VBN
cord-022313-2675sjlf	84	35	lipid	lipid	NN
cord-022313-2675sjlf	84	36	-	-	HYPH
cord-022313-2675sjlf	84	37	linked	link	VBN
cord-022313-2675sjlf	84	38	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	84	39	donor	donor	NN
cord-022313-2675sjlf	84	40	.	.	.
cord-022313-2675sjlf	85	1	To	to	TO
cord-022313-2675sjlf	85	2	study	study	VB
cord-022313-2675sjlf	85	3	this	this	DT
cord-022313-2675sjlf	85	4	pathway	pathway	NN
cord-022313-2675sjlf	85	5	in	in	IN
cord-022313-2675sjlf	85	6	animal	animal	NN
cord-022313-2675sjlf	85	7	cell	cell	NN
cord-022313-2675sjlf	85	8	culture	culture	NN
cord-022313-2675sjlf	85	9	systems	system	NNS
cord-022313-2675sjlf	85	10	,	,	,
cord-022313-2675sjlf	85	11	one	one	PRP
cord-022313-2675sjlf	85	12	can	can	MD
cord-022313-2675sjlf	85	13	add	add	VB
cord-022313-2675sjlf	85	14	one	one	CD
cord-022313-2675sjlf	85	15	of	of	IN
cord-022313-2675sjlf	85	16	the	the	DT
cord-022313-2675sjlf	85	17	radioactive	radioactive	JJ
cord-022313-2675sjlf	85	18	sugars	sugar	NNS
cord-022313-2675sjlf	85	19	,	,	,
cord-022313-2675sjlf	85	20	i.e.	i.e.	FW
cord-022313-2675sjlf	85	21	,	,	,
cord-022313-2675sjlf	85	22	[	[	-LRB-
cord-022313-2675sjlf	85	23	3	3	CD
cord-022313-2675sjlf	85	24	H]glucosamine	H]glucosamine	NNP
cord-022313-2675sjlf	85	25	,	,	,
cord-022313-2675sjlf	85	26	[	[	-LRB-
cord-022313-2675sjlf	85	27	3	3	CD
cord-022313-2675sjlf	85	28	H]galactose	H]galactose	NNP
cord-022313-2675sjlf	85	29	(	(	-LRB-
cord-022313-2675sjlf	85	30	as	as	IN
cord-022313-2675sjlf	85	31	a	a	DT
cord-022313-2675sjlf	85	32	tag	tag	NN
cord-022313-2675sjlf	85	33	for	for	IN
cord-022313-2675sjlf	85	34	the	the	DT
cord-022313-2675sjlf	85	35	glucose	glucose	NN
cord-022313-2675sjlf	85	36	residues	residue	NNS
cord-022313-2675sjlf	85	37	)	)	-RRB-
cord-022313-2675sjlf	85	38	,	,	,
cord-022313-2675sjlf	85	39	or	or	CC
cord-022313-2675sjlf	85	40	[	[	-LRB-
cord-022313-2675sjlf	85	41	3	3	CD
cord-022313-2675sjlf	85	42	H]mannose	H]mannose	NNP
cord-022313-2675sjlf	85	43	,	,	,
cord-022313-2675sjlf	85	44	to	to	IN
cord-022313-2675sjlf	85	45	the	the	DT
cord-022313-2675sjlf	85	46	medium	medium	NN
cord-022313-2675sjlf	85	47	and	and	CC
cord-022313-2675sjlf	85	48	examine	examine	VB
cord-022313-2675sjlf	85	49	the	the	DT
cord-022313-2675sjlf	85	50	incorporation	incorporation	NN
cord-022313-2675sjlf	85	51	of	of	IN
cord-022313-2675sjlf	85	52	the	the	DT
cord-022313-2675sjlf	85	53	label	label	NN
cord-022313-2675sjlf	85	54	into	into	IN
cord-022313-2675sjlf	85	55	lipid	lipid	NN
cord-022313-2675sjlf	85	56	-	-	HYPH
cord-022313-2675sjlf	85	57	linked	link	VBN
cord-022313-2675sjlf	85	58	saccharides	saccharide	NNS
cord-022313-2675sjlf	85	59	.	.	.
cord-022313-2675sjlf	86	1	These	these	DT
cord-022313-2675sjlf	86	2	intermediates	intermediate	NNS
cord-022313-2675sjlf	86	3	are	be	VBP
cord-022313-2675sjlf	86	4	easy	easy	JJ
cord-022313-2675sjlf	86	5	to	to	TO
cord-022313-2675sjlf	86	6	extract	extract	VB
cord-022313-2675sjlf	86	7	from	from	IN
cord-022313-2675sjlf	86	8	the	the	DT
cord-022313-2675sjlf	86	9	cells	cell	NNS
cord-022313-2675sjlf	86	10	by	by	IN
cord-022313-2675sjlf	86	11	a	a	DT
cord-022313-2675sjlf	86	12	sequential	sequential	JJ
cord-022313-2675sjlf	86	13	extraction	extraction	NN
cord-022313-2675sjlf	86	14	procedure	procedure	NN
cord-022313-2675sjlf	86	15	,	,	,
cord-022313-2675sjlf	86	16	first	first	RB
cord-022313-2675sjlf	86	17	with	with	IN
cord-022313-2675sjlf	86	18	CHC1	CHC1	NNP
cord-022313-2675sjlf	86	19	3	3	CD
cord-022313-2675sjlf	86	20	:	:	:
cord-022313-2675sjlf	86	21	CH	CH	NNP
cord-022313-2675sjlf	86	22	3	3	CD
cord-022313-2675sjlf	86	23	0H	0h	NN
cord-022313-2675sjlf	86	24	:	:	:
cord-022313-2675sjlf	87	1	H	h	NN
cord-022313-2675sjlf	87	2	2	2	CD
cord-022313-2675sjlf	87	3	0	0	NFP
cord-022313-2675sjlf	87	4	(	(	-LRB-
cord-022313-2675sjlf	87	5	1:1:1	1:1:1	CD
cord-022313-2675sjlf	87	6	)	)	-RRB-
cord-022313-2675sjlf	87	7	,	,	,
cord-022313-2675sjlf	87	8	which	which	WDT
cord-022313-2675sjlf	87	9	ex	ex	VBZ
cord-022313-2675sjlf	87	10	tracts	tract	VBZ
cord-022313-2675sjlf	87	11	the	the	DT
cord-022313-2675sjlf	87	12	lipid	lipid	NN
cord-022313-2675sjlf	87	13	-	-	HYPH
cord-022313-2675sjlf	87	14	linked	link	VBN
cord-022313-2675sjlf	87	15	monosaccharides	monosaccharide	NNS
cord-022313-2675sjlf	87	16	and	and	CC
cord-022313-2675sjlf	87	17	smaller	small	JJR
cord-022313-2675sjlf	87	18	sized	sized	JJ
cord-022313-2675sjlf	87	19	lipid	lipid	NN
cord-022313-2675sjlf	87	20	-	-	HYPH
cord-022313-2675sjlf	87	21	linked	link	VBN
cord-022313-2675sjlf	87	22	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	87	23	,	,	,
cord-022313-2675sjlf	87	24	and	and	CC
cord-022313-2675sjlf	87	25	then	then	RB
cord-022313-2675sjlf	87	26	extraction	extraction	NN
cord-022313-2675sjlf	87	27	of	of	IN
cord-022313-2675sjlf	87	28	the	the	DT
cord-022313-2675sjlf	87	29	remaining	remain	VBG
cord-022313-2675sjlf	87	30	residue	residue	NN
cord-022313-2675sjlf	87	31	with	with	IN
cord-022313-2675sjlf	87	32	CHC1	CHC1	NNP
cord-022313-2675sjlf	87	33	3	3	CD
cord-022313-2675sjlf	88	1	:	:	:
cord-022313-2675sjlf	88	2	CH	CH	NNP
cord-022313-2675sjlf	88	3	3	3	CD
cord-022313-2675sjlf	88	4	0H	0h	NN
cord-022313-2675sjlf	88	5	:	:	:
cord-022313-2675sjlf	89	1	H	h	NN
cord-022313-2675sjlf	89	2	2	2	CD
cord-022313-2675sjlf	89	3	0	0	CD
cord-022313-2675sjlf	89	4	(	(	-LRB-
cord-022313-2675sjlf	89	5	10:10:3	10:10:3	CD
cord-022313-2675sjlf	89	6	)	)	-RRB-
cord-022313-2675sjlf	89	7	to	to	TO
cord-022313-2675sjlf	89	8	obtain	obtain	VB
cord-022313-2675sjlf	89	9	the	the	DT
cord-022313-2675sjlf	89	10	lipid	lipid	NN
cord-022313-2675sjlf	89	11	-	-	HYPH
cord-022313-2675sjlf	89	12	linked	link	VBN
cord-022313-2675sjlf	89	13	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	89	14	that	that	WDT
cord-022313-2675sjlf	89	15	contain	contain	VBP
cord-022313-2675sjlf	89	16	the	the	DT
cord-022313-2675sjlf	89	17	larger	large	JJR
cord-022313-2675sjlf	89	18	sized	sized	JJ
cord-022313-2675sjlf	89	19	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	89	20	.	.	.
cord-022313-2675sjlf	90	1	The	the	DT
cord-022313-2675sjlf	90	2	intact	intact	JJ
cord-022313-2675sjlf	90	3	lipid	lipid	NN
cord-022313-2675sjlf	90	4	-	-	HYPH
cord-022313-2675sjlf	90	5	linked	link	VBN
cord-022313-2675sjlf	90	6	monosaccharides	monosaccharide	NNS
cord-022313-2675sjlf	90	7	can	can	MD
cord-022313-2675sjlf	90	8	usually	usually	RB
cord-022313-2675sjlf	90	9	be	be	VB
cord-022313-2675sjlf	90	10	identified	identify	VBN
cord-022313-2675sjlf	90	11	by	by	IN
cord-022313-2675sjlf	90	12	TLC	TLC	NNP
cord-022313-2675sjlf	90	13	,	,	,
cord-022313-2675sjlf	90	14	whereas	whereas	IN
cord-022313-2675sjlf	90	15	the	the	DT
cord-022313-2675sjlf	90	16	larger	large	JJR
cord-022313-2675sjlf	90	17	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	90	18	from	from	IN
cord-022313-2675sjlf	90	19	the	the	DT
cord-022313-2675sjlf	90	20	lipid	lipid	NN
cord-022313-2675sjlf	90	21	-	-	HYPH
cord-022313-2675sjlf	90	22	linked	link	VBN
cord-022313-2675sjlf	90	23	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	90	24	are	be	VBP
cord-022313-2675sjlf	90	25	usually	usually	RB
cord-022313-2675sjlf	90	26	re	re	VBN
cord-022313-2675sjlf	90	27	leased	lease	VBN
cord-022313-2675sjlf	90	28	by	by	IN
cord-022313-2675sjlf	90	29	mild	mild	JJ
cord-022313-2675sjlf	90	30	acid	acid	JJ
cord-022313-2675sjlf	90	31	hydrolysis	hydrolysis	NN
cord-022313-2675sjlf	90	32	and	and	CC
cord-022313-2675sjlf	90	33	characterized	characterize	VBN
cord-022313-2675sjlf	90	34	by	by	IN
cord-022313-2675sjlf	90	35	gel	gel	NN
cord-022313-2675sjlf	90	36	filtration	filtration	NN
cord-022313-2675sjlf	90	37	on	on	IN
cord-022313-2675sjlf	90	38	Bio	Bio	NNP
cord-022313-2675sjlf	90	39	-	-	HYPH
cord-022313-2675sjlf	90	40	Gel	Gel	NNP
cord-022313-2675sjlf	90	41	P-4	P-4	NNP
cord-022313-2675sjlf	90	42	or	or	CC
cord-022313-2675sjlf	90	43	by	by	IN
cord-022313-2675sjlf	90	44	HPLC	HPLC	NNP
cord-022313-2675sjlf	90	45	(	(	-LRB-
cord-022313-2675sjlf	90	46	29	29	CD
cord-022313-2675sjlf	90	47	,	,	,
cord-022313-2675sjlf	90	48	30	30	CD
cord-022313-2675sjlf	90	49	)	)	-RRB-
cord-022313-2675sjlf	90	50	.	.	.
cord-022313-2675sjlf	91	1	Thus	thus	RB
cord-022313-2675sjlf	91	2	,	,	,
cord-022313-2675sjlf	91	3	the	the	DT
cord-022313-2675sjlf	91	4	first	first	JJ
cord-022313-2675sjlf	91	5	enzyme	enzyme	NN
cord-022313-2675sjlf	91	6	in	in	IN
cord-022313-2675sjlf	91	7	the	the	DT
cord-022313-2675sjlf	91	8	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	91	9	of	of	IN
cord-022313-2675sjlf	91	10	N	N	NNP
cord-022313-2675sjlf	91	11	-	-	HYPH
cord-022313-2675sjlf	91	12	linked	link	VBN
cord-022313-2675sjlf	91	13	oligosaccha	oligosaccha	NN
cord-022313-2675sjlf	91	14	rides	ride	NNS
cord-022313-2675sjlf	91	15	transfers	transfer	VBZ
cord-022313-2675sjlf	91	16	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	91	17	-	-	HYPH
cord-022313-2675sjlf	91	18	l	l	NN
cord-022313-2675sjlf	91	19	-	-	HYPH
cord-022313-2675sjlf	91	20	P	p	NN
cord-022313-2675sjlf	91	21	from	from	IN
cord-022313-2675sjlf	91	22	UDP	udp	NN
cord-022313-2675sjlf	91	23	-	-	HYPH
cord-022313-2675sjlf	91	24	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	91	25	to	to	IN
cord-022313-2675sjlf	91	26	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	91	27	-	-	HYPH
cord-022313-2675sjlf	91	28	P	p	NN
cord-022313-2675sjlf	91	29	to	to	TO
cord-022313-2675sjlf	91	30	form	form	VB
cord-022313-2675sjlf	91	31	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	91	32	-	-	HYPH
cord-022313-2675sjlf	91	33	PP	PP	NNP
cord-022313-2675sjlf	91	34	-	-	HYPH
cord-022313-2675sjlf	91	35	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	91	36	(	(	-LRB-
cord-022313-2675sjlf	91	37	31	31	CD
cord-022313-2675sjlf	91	38	,	,	,
cord-022313-2675sjlf	91	39	32	32	CD
cord-022313-2675sjlf	91	40	)	)	-RRB-
cord-022313-2675sjlf	91	41	.	.	.
cord-022313-2675sjlf	92	1	This	this	DT
cord-022313-2675sjlf	92	2	enzyme	enzyme	NN
cord-022313-2675sjlf	92	3	is	be	VBZ
cord-022313-2675sjlf	92	4	the	the	DT
cord-022313-2675sjlf	92	5	site	site	NN
cord-022313-2675sjlf	92	6	of	of	IN
cord-022313-2675sjlf	92	7	action	action	NN
cord-022313-2675sjlf	92	8	of	of	IN
cord-022313-2675sjlf	92	9	the	the	DT
cord-022313-2675sjlf	92	10	very	very	RB
cord-022313-2675sjlf	92	11	widely	widely	RB
cord-022313-2675sjlf	92	12	used	use	VBN
cord-022313-2675sjlf	92	13	glycosylation	glycosylation	NN
cord-022313-2675sjlf	92	14	inhibitor	inhibitor	NN
cord-022313-2675sjlf	92	15	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	92	16	(	(	-LRB-
cord-022313-2675sjlf	92	17	21	21	CD
cord-022313-2675sjlf	92	18	)	)	-RRB-
cord-022313-2675sjlf	92	19	(	(	-LRB-
cord-022313-2675sjlf	92	20	discussed	discuss	VBN
cord-022313-2675sjlf	92	21	later	later	RB
cord-022313-2675sjlf	92	22	)	)	-RRB-
cord-022313-2675sjlf	92	23	.	.	.
cord-022313-2675sjlf	93	1	The	the	DT
cord-022313-2675sjlf	93	2	GlcNAc-1-P	glcnac-1-p	JJ
cord-022313-2675sjlf	93	3	transferase	transferase	NN
cord-022313-2675sjlf	93	4	has	have	VBZ
cord-022313-2675sjlf	93	5	been	be	VBN
cord-022313-2675sjlf	93	6	purified	purify	VBN
cord-022313-2675sjlf	93	7	to	to	IN
cord-022313-2675sjlf	93	8	homogeneity	homogeneity	NN
cord-022313-2675sjlf	93	9	from	from	IN
cord-022313-2675sjlf	93	10	bovine	bovine	JJ
cord-022313-2675sjlf	93	11	mammary	mammary	JJ
cord-022313-2675sjlf	93	12	glands	gland	NNS
cord-022313-2675sjlf	93	13	(	(	-LRB-
cord-022313-2675sjlf	93	14	33	33	CD
cord-022313-2675sjlf	93	15	)	)	-RRB-
cord-022313-2675sjlf	93	16	,	,	,
cord-022313-2675sjlf	93	17	and	and	CC
cord-022313-2675sjlf	93	18	the	the	DT
cord-022313-2675sjlf	93	19	gene	gene	NN
cord-022313-2675sjlf	93	20	for	for	IN
cord-022313-2675sjlf	93	21	this	this	DT
cord-022313-2675sjlf	93	22	enzyme	enzyme	NN
cord-022313-2675sjlf	93	23	was	be	VBD
cord-022313-2675sjlf	93	24	recently	recently	RB
cord-022313-2675sjlf	93	25	cloned	clone	VBN
cord-022313-2675sjlf	93	26	and	and	CC
cord-022313-2675sjlf	93	27	expressed	express	VBN
cord-022313-2675sjlf	93	28	is	be	VBZ
cord-022313-2675sjlf	93	29	COS	COS	NNP
cord-022313-2675sjlf	93	30	cells	cell	NNS
cord-022313-2675sjlf	93	31	(	(	-LRB-
cord-022313-2675sjlf	93	32	34	34	CD
cord-022313-2675sjlf	93	33	)	)	-RRB-
cord-022313-2675sjlf	93	34	.	.	.
cord-022313-2675sjlf	94	1	The	the	DT
cord-022313-2675sjlf	94	2	next	next	JJ
cord-022313-2675sjlf	94	3	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	94	4	transferase	transferase	NN
cord-022313-2675sjlf	94	5	adds	add	VBZ
cord-022313-2675sjlf	94	6	the	the	DT
cord-022313-2675sjlf	94	7	second	second	JJ
cord-022313-2675sjlf	94	8	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	94	9	,	,	,
cord-022313-2675sjlf	94	10	also	also	RB
cord-022313-2675sjlf	94	11	from	from	IN
cord-022313-2675sjlf	94	12	UDP	UDP	NNP
cord-022313-2675sjlf	94	13	-	-	HYPH
cord-022313-2675sjlf	94	14	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	94	15	,	,	,
cord-022313-2675sjlf	94	16	to	to	IN
cord-022313-2675sjlf	94	17	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	94	18	-	-	HYPH
cord-022313-2675sjlf	94	19	PP	PP	NNP
cord-022313-2675sjlf	94	20	-	-	HYPH
cord-022313-2675sjlf	94	21	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	94	22	to	to	TO
cord-022313-2675sjlf	94	23	form	form	VB
cord-022313-2675sjlf	94	24	GlcNAc/31,4GlcNAc	GlcNAc/31,4GlcNAc	NNP
cord-022313-2675sjlf	94	25	-	-	HYPH
cord-022313-2675sjlf	94	26	PP	PP	NNP
cord-022313-2675sjlf	94	27	-	-	HYPH
cord-022313-2675sjlf	94	28	dolichol	dolichol	NNP
cord-022313-2675sjlf	94	29	.	.	.
cord-022313-2675sjlf	95	1	This	this	DT
cord-022313-2675sjlf	95	2	en	en	FW
cord-022313-2675sjlf	95	3	zyme	zyme	NNP
cord-022313-2675sjlf	95	4	has	have	VBZ
cord-022313-2675sjlf	95	5	recently	recently	RB
cord-022313-2675sjlf	95	6	been	be	VBN
cord-022313-2675sjlf	95	7	purified	purify	VBN
cord-022313-2675sjlf	95	8	to	to	IN
cord-022313-2675sjlf	95	9	homogeneity	homogeneity	NN
cord-022313-2675sjlf	95	10	from	from	IN
cord-022313-2675sjlf	95	11	pig	pig	NN
cord-022313-2675sjlf	95	12	aorta	aorta	NN
cord-022313-2675sjlf	95	13	(	(	-LRB-
cord-022313-2675sjlf	95	14	35	35	CD
cord-022313-2675sjlf	95	15	)	)	-RRB-
cord-022313-2675sjlf	95	16	.	.	.
cord-022313-2675sjlf	96	1	The	the	DT
cord-022313-2675sjlf	96	2	next	next	JJ
cord-022313-2675sjlf	96	3	five	five	CD
cord-022313-2675sjlf	96	4	sugars	sugar	NNS
cord-022313-2675sjlf	96	5	to	to	TO
cord-022313-2675sjlf	96	6	be	be	VB
cord-022313-2675sjlf	96	7	added	add	VBN
cord-022313-2675sjlf	96	8	are	be	VBP
cord-022313-2675sjlf	96	9	mannose	mannose	NN
cord-022313-2675sjlf	96	10	residues	residue	NNS
cord-022313-2675sjlf	96	11	and	and	CC
cord-022313-2675sjlf	96	12	are	be	VBP
cord-022313-2675sjlf	96	13	do	do	VB
cord-022313-2675sjlf	96	14	nated	nate	VBN
cord-022313-2675sjlf	96	15	via	via	IN
cord-022313-2675sjlf	96	16	GDP	gdp	NN
cord-022313-2675sjlf	96	17	-	-	HYPH
cord-022313-2675sjlf	96	18	mannose	mannose	NN
cord-022313-2675sjlf	96	19	.	.	.
cord-022313-2675sjlf	97	1	As	as	IN
cord-022313-2675sjlf	97	2	indicated	indicate	VBN
cord-022313-2675sjlf	97	3	below	below	RB
cord-022313-2675sjlf	97	4	,	,	,
cord-022313-2675sjlf	97	5	two	two	CD
cord-022313-2675sjlf	97	6	lines	line	NNS
cord-022313-2675sjlf	97	7	of	of	IN
cord-022313-2675sjlf	97	8	evidence	evidence	NN
cord-022313-2675sjlf	97	9	have	have	VBP
cord-022313-2675sjlf	97	10	demonstrated	demonstrate	VBN
cord-022313-2675sjlf	97	11	that	that	IN
cord-022313-2675sjlf	97	12	GDP	gdp	NN
cord-022313-2675sjlf	97	13	-	-	HYPH
cord-022313-2675sjlf	97	14	mannose	mannose	NN
cord-022313-2675sjlf	97	15	,	,	,
cord-022313-2675sjlf	97	16	rather	rather	RB
cord-022313-2675sjlf	97	17	than	than	IN
cord-022313-2675sjlf	97	18	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	97	19	-	-	:
cord-022313-2675sjlf	97	20	Pmannose	Pmannose	NNP
cord-022313-2675sjlf	97	21	,	,	,
cord-022313-2675sjlf	97	22	is	be	VBZ
cord-022313-2675sjlf	97	23	the	the	DT
cord-022313-2675sjlf	97	24	mannosyl	mannosyl	NNP
cord-022313-2675sjlf	97	25	donor	donor	NN
cord-022313-2675sjlf	97	26	for	for	IN
cord-022313-2675sjlf	97	27	these	these	DT
cord-022313-2675sjlf	97	28	additions	addition	NNS
cord-022313-2675sjlf	97	29	:	:	:
cord-022313-2675sjlf	97	30	(	(	-LRB-
cord-022313-2675sjlf	97	31	a	a	LS
cord-022313-2675sjlf	97	32	)	)	-RRB-
cord-022313-2675sjlf	98	1	A	a	DT
cord-022313-2675sjlf	98	2	mutant	mutant	JJ
cord-022313-2675sjlf	98	3	cell	cell	NN
cord-022313-2675sjlf	98	4	line	line	NN
cord-022313-2675sjlf	98	5	that	that	WDT
cord-022313-2675sjlf	98	6	is	be	VBZ
cord-022313-2675sjlf	98	7	missing	miss	VBG
cord-022313-2675sjlf	98	8	the	the	DT
cord-022313-2675sjlf	98	9	dolichyl	dolichyl	NN
cord-022313-2675sjlf	98	10	-	-	HYPH
cord-022313-2675sjlf	98	11	P	p	NN
cord-022313-2675sjlf	98	12	-	-	HYPH
cord-022313-2675sjlf	98	13	mannose	mannose	NN
cord-022313-2675sjlf	98	14	synthase	synthase	NN
cord-022313-2675sjlf	98	15	can	can	MD
cord-022313-2675sjlf	98	16	still	still	RB
cord-022313-2675sjlf	98	17	form	form	VB
cord-022313-2675sjlf	98	18	the	the	DT
cord-022313-2675sjlf	98	19	Manal,2Manal,2Manal,3(Manal,6)Man	Manal,2Manal,2Manal,3(Manal,6)Man	NNP
cord-022313-2675sjlf	98	20	i	i	PRP
cord-022313-2675sjlf	98	21	81,4GlcNAci81,4GlcNAc	81,4glcnaci81,4glcnac	CD
cord-022313-2675sjlf	98	22	-	-	:
cord-022313-2675sjlf	98	23	PPdolichol	PPdolichol	NNP
cord-022313-2675sjlf	98	24	but	but	CC
cord-022313-2675sjlf	98	25	is	be	VBZ
cord-022313-2675sjlf	98	26	not	not	RB
cord-022313-2675sjlf	98	27	able	able	JJ
cord-022313-2675sjlf	98	28	to	to	TO
cord-022313-2675sjlf	98	29	further	further	RB
cord-022313-2675sjlf	98	30	elongate	elongate	VB
cord-022313-2675sjlf	98	31	it	-PRON-	PRP
cord-022313-2675sjlf	98	32	(	(	-LRB-
cord-022313-2675sjlf	98	33	36	36	CD
cord-022313-2675sjlf	98	34	)	)	-RRB-
cord-022313-2675sjlf	98	35	;	;	:
cord-022313-2675sjlf	98	36	and	and	CC
cord-022313-2675sjlf	98	37	(	(	-LRB-
cord-022313-2675sjlf	98	38	b	b	NN
cord-022313-2675sjlf	98	39	)	)	-RRB-
cord-022313-2675sjlf	98	40	amphomycin	amphomycin	NNP
cord-022313-2675sjlf	98	41	,	,	,
cord-022313-2675sjlf	98	42	an	an	DT
cord-022313-2675sjlf	98	43	inhibitor	inhibitor	NN
cord-022313-2675sjlf	98	44	of	of	IN
cord-022313-2675sjlf	98	45	the	the	DT
cord-022313-2675sjlf	98	46	in	in	FW
cord-022313-2675sjlf	98	47	vitro	vitro	FW
cord-022313-2675sjlf	98	48	formation	formation	NN
cord-022313-2675sjlf	98	49	of	of	IN
cord-022313-2675sjlf	98	50	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	98	51	-	-	HYPH
cord-022313-2675sjlf	98	52	P	p	NN
cord-022313-2675sjlf	98	53	-	-	HYPH
cord-022313-2675sjlf	98	54	mannose	mannose	NN
cord-022313-2675sjlf	98	55	(	(	-LRB-
cord-022313-2675sjlf	98	56	37	37	CD
cord-022313-2675sjlf	98	57	)	)	-RRB-
cord-022313-2675sjlf	98	58	,	,	,
cord-022313-2675sjlf	98	59	does	do	VBZ
cord-022313-2675sjlf	98	60	not	not	RB
cord-022313-2675sjlf	98	61	prevent	prevent	VB
cord-022313-2675sjlf	98	62	the	the	DT
cord-022313-2675sjlf	98	63	formation	formation	NN
cord-022313-2675sjlf	98	64	of	of	IN
cord-022313-2675sjlf	98	65	the	the	DT
cord-022313-2675sjlf	98	66	above	above	JJ
cord-022313-2675sjlf	98	67	Man	Man	NNP
cord-022313-2675sjlf	98	68	5	5	CD
cord-022313-2675sjlf	98	69	(	(	-LRB-
cord-022313-2675sjlf	98	70	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	98	71	)	)	-RRB-
cord-022313-2675sjlf	98	72	2	2	CD
cord-022313-2675sjlf	98	73	-PP	-PP	NNS
cord-022313-2675sjlf	98	74	-	-	HYPH
cord-022313-2675sjlf	98	75	dolichol	dolichol	JJ
cord-022313-2675sjlf	98	76	,	,	,
cord-022313-2675sjlf	98	77	but	but	CC
cord-022313-2675sjlf	98	78	it	-PRON-	PRP
cord-022313-2675sjlf	98	79	does	do	VBZ
cord-022313-2675sjlf	98	80	block	block	VB
cord-022313-2675sjlf	98	81	further	further	JJ
cord-022313-2675sjlf	98	82	elongation	elongation	NN
cord-022313-2675sjlf	98	83	of	of	IN
cord-022313-2675sjlf	98	84	this	this	DT
cord-022313-2675sjlf	98	85	intermediate	intermediate	JJ
cord-022313-2675sjlf	98	86	(	(	-LRB-
cord-022313-2675sjlf	98	87	38	38	CD
cord-022313-2675sjlf	98	88	)	)	-RRB-
cord-022313-2675sjlf	98	89	.	.	.
cord-022313-2675sjlf	99	1	The	the	DT
cord-022313-2675sjlf	99	2	βmannosyl	βmannosyl	JJ
cord-022313-2675sjlf	99	3	transferase	transferase	NN
cord-022313-2675sjlf	99	4	that	that	WDT
cord-022313-2675sjlf	99	5	adds	add	VBZ
cord-022313-2675sjlf	99	6	the	the	DT
cord-022313-2675sjlf	99	7	first	first	JJ
cord-022313-2675sjlf	99	8	mannose	mannose	NN
cord-022313-2675sjlf	99	9	to	to	IN
cord-022313-2675sjlf	99	10	the	the	DT
cord-022313-2675sjlf	99	11	dolichol	dolichol	NNP
cord-022313-2675sjlf	99	12	inter	inter	NNP
cord-022313-2675sjlf	99	13	mediates	mediate	VBZ
cord-022313-2675sjlf	99	14	has	have	VBZ
cord-022313-2675sjlf	99	15	recently	recently	RB
cord-022313-2675sjlf	99	16	been	be	VBN
cord-022313-2675sjlf	99	17	purified	purify	VBN
cord-022313-2675sjlf	99	18	to	to	IN
cord-022313-2675sjlf	99	19	homogeneity	homogeneity	NN
cord-022313-2675sjlf	99	20	from	from	IN
cord-022313-2675sjlf	99	21	pig	pig	NN
cord-022313-2675sjlf	99	22	aorta	aorta	NN
cord-022313-2675sjlf	99	23	,	,	,
cord-022313-2675sjlf	99	24	and	and	CC
cord-022313-2675sjlf	99	25	an	an	DT
cord-022313-2675sjlf	99	26	azido	azido	NNP
cord-022313-2675sjlf	99	27	-	-	HYPH
cord-022313-2675sjlf	99	28	labeled	label	VBN
cord-022313-2675sjlf	99	29	[	[	-LRB-
cord-022313-2675sjlf	99	30	32	32	CD
cord-022313-2675sjlf	99	31	P]GDP	p]gdp	NN
cord-022313-2675sjlf	99	32	-	-	HYPH
cord-022313-2675sjlf	99	33	mannose	mannose	NN
cord-022313-2675sjlf	99	34	was	be	VBD
cord-022313-2675sjlf	99	35	used	use	VBN
cord-022313-2675sjlf	99	36	to	to	TO
cord-022313-2675sjlf	99	37	identify	identify	VB
cord-022313-2675sjlf	99	38	the	the	DT
cord-022313-2675sjlf	99	39	subunits	subunit	NNS
cord-022313-2675sjlf	99	40	of	of	IN
cord-022313-2675sjlf	99	41	this	this	DT
cord-022313-2675sjlf	99	42	protein	protein	NN
cord-022313-2675sjlf	99	43	(	(	-LRB-
cord-022313-2675sjlf	99	44	39	39	CD
cord-022313-2675sjlf	99	45	)	)	-RRB-
cord-022313-2675sjlf	99	46	.	.	.
cord-022313-2675sjlf	100	1	Several	several	JJ
cord-022313-2675sjlf	100	2	of	of	IN
cord-022313-2675sjlf	100	3	the	the	DT
cord-022313-2675sjlf	100	4	α	α	NN
cord-022313-2675sjlf	100	5	-	-	HYPH
cord-022313-2675sjlf	100	6	mannosytransferases	mannosytransferase	NNS
cord-022313-2675sjlf	100	7	have	have	VBP
cord-022313-2675sjlf	100	8	also	also	RB
cord-022313-2675sjlf	100	9	been	be	VBN
cord-022313-2675sjlf	100	10	partially	partially	RB
cord-022313-2675sjlf	100	11	purified	purify	VBN
cord-022313-2675sjlf	100	12	from	from	IN
cord-022313-2675sjlf	100	13	liver	liver	NN
cord-022313-2675sjlf	100	14	(	(	-LRB-
cord-022313-2675sjlf	100	15	40	40	CD
cord-022313-2675sjlf	100	16	)	)	-RRB-
cord-022313-2675sjlf	100	17	(	(	-LRB-
cord-022313-2675sjlf	100	18	41	41	CD
cord-022313-2675sjlf	100	19	)	)	-RRB-
cord-022313-2675sjlf	100	20	(	(	-LRB-
cord-022313-2675sjlf	100	21	42	42	CD
cord-022313-2675sjlf	100	22	)	)	-RRB-
cord-022313-2675sjlf	100	23	(	(	-LRB-
cord-022313-2675sjlf	100	24	43	43	CD
cord-022313-2675sjlf	100	25	)	)	-RRB-
cord-022313-2675sjlf	100	26	,	,	,
cord-022313-2675sjlf	100	27	and	and	CC
cord-022313-2675sjlf	100	28	these	these	DT
cord-022313-2675sjlf	100	29	enzymes	enzyme	NNS
cord-022313-2675sjlf	100	30	require	require	VBP
cord-022313-2675sjlf	100	31	GDP	gdp	NN
cord-022313-2675sjlf	100	32	-	-	HYPH
cord-022313-2675sjlf	100	33	mannose	mannose	NN
cord-022313-2675sjlf	100	34	rather	rather	RB
cord-022313-2675sjlf	100	35	than	than	IN
cord-022313-2675sjlf	100	36	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	100	37	-	-	HYPH
cord-022313-2675sjlf	100	38	P	p	NN
cord-022313-2675sjlf	100	39	-	-	HYPH
cord-022313-2675sjlf	100	40	mannose	mannose	NN
cord-022313-2675sjlf	100	41	as	as	IN
cord-022313-2675sjlf	100	42	the	the	DT
cord-022313-2675sjlf	100	43	manno	manno	NNP
cord-022313-2675sjlf	100	44	syl	syl	NNP
cord-022313-2675sjlf	100	45	donor	donor	NN
cord-022313-2675sjlf	100	46	.	.	.
cord-022313-2675sjlf	101	1	However	however	RB
cord-022313-2675sjlf	101	2	,	,	,
cord-022313-2675sjlf	101	3	these	these	DT
cord-022313-2675sjlf	101	4	proteins	protein	NNS
cord-022313-2675sjlf	101	5	have	have	VBP
cord-022313-2675sjlf	101	6	not	not	RB
cord-022313-2675sjlf	101	7	yet	yet	RB
cord-022313-2675sjlf	101	8	been	be	VBN
cord-022313-2675sjlf	101	9	purified	purify	VBN
cord-022313-2675sjlf	101	10	to	to	IN
cord-022313-2675sjlf	101	11	homo	homo	NN
cord-022313-2675sjlf	101	12	geneity	geneity	NN
cord-022313-2675sjlf	101	13	so	so	IN
cord-022313-2675sjlf	101	14	that	that	IN
cord-022313-2675sjlf	101	15	their	-PRON-	PRP$
cord-022313-2675sjlf	101	16	detailed	detailed	JJ
cord-022313-2675sjlf	101	17	properties	property	NNS
cord-022313-2675sjlf	101	18	or	or	CC
cord-022313-2675sjlf	101	19	their	-PRON-	PRP$
cord-022313-2675sjlf	101	20	orientation	orientation	NN
cord-022313-2675sjlf	101	21	in	in	IN
cord-022313-2675sjlf	101	22	the	the	DT
cord-022313-2675sjlf	101	23	ER	ER	NNP
cord-022313-2675sjlf	101	24	membrane	membrane	NN
cord-022313-2675sjlf	101	25	is	be	VBZ
cord-022313-2675sjlf	101	26	not	not	RB
cord-022313-2675sjlf	101	27	known	know	VBN
cord-022313-2675sjlf	101	28	.	.	.
cord-022313-2675sjlf	102	1	Once	once	IN
cord-022313-2675sjlf	102	2	the	the	DT
cord-022313-2675sjlf	102	3	Man	man	NN
cord-022313-2675sjlf	102	4	5	5	CD
cord-022313-2675sjlf	102	5	(	(	-LRB-
cord-022313-2675sjlf	102	6	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	102	7	)	)	-RRB-
cord-022313-2675sjlf	102	8	2	2	CD
cord-022313-2675sjlf	102	9	-PP	-PP	NNS
cord-022313-2675sjlf	102	10	-	-	HYPH
cord-022313-2675sjlf	102	11	dolichol	dolichol	NNP
cord-022313-2675sjlf	102	12	is	be	VBZ
cord-022313-2675sjlf	102	13	formed	form	VBN
cord-022313-2675sjlf	102	14	,	,	,
cord-022313-2675sjlf	102	15	it	-PRON-	PRP
cord-022313-2675sjlf	102	16	can	can	MD
cord-022313-2675sjlf	102	17	be	be	VB
cord-022313-2675sjlf	102	18	further	further	RB
cord-022313-2675sjlf	102	19	glycosylated	glycosylate	VBN
cord-022313-2675sjlf	102	20	by	by	IN
cord-022313-2675sjlf	102	21	the	the	DT
cord-022313-2675sjlf	102	22	addition	addition	NN
cord-022313-2675sjlf	102	23	of	of	IN
cord-022313-2675sjlf	102	24	four	four	CD
cord-022313-2675sjlf	102	25	more	more	JJR
cord-022313-2675sjlf	102	26	mannose	mannose	NN
cord-022313-2675sjlf	102	27	residues	residue	NNS
cord-022313-2675sjlf	102	28	and	and	CC
cord-022313-2675sjlf	102	29	then	then	RB
cord-022313-2675sjlf	102	30	three	three	CD
cord-022313-2675sjlf	102	31	glucose	glucose	NN
cord-022313-2675sjlf	102	32	units	unit	NNS
cord-022313-2675sjlf	102	33	(	(	-LRB-
cord-022313-2675sjlf	102	34	44	44	CD
cord-022313-2675sjlf	102	35	)	)	-RRB-
cord-022313-2675sjlf	102	36	.	.	.
cord-022313-2675sjlf	103	1	These	these	DT
cord-022313-2675sjlf	103	2	mannose	mannose	NN
cord-022313-2675sjlf	103	3	residues	residue	NNS
cord-022313-2675sjlf	103	4	all	all	DT
cord-022313-2675sjlf	103	5	are	be	VBP
cord-022313-2675sjlf	103	6	believed	believe	VBN
cord-022313-2675sjlf	103	7	to	to	TO
cord-022313-2675sjlf	103	8	be	be	VB
cord-022313-2675sjlf	103	9	donated	donate	VBN
cord-022313-2675sjlf	103	10	via	via	IN
cord-022313-2675sjlf	103	11	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	103	12	-	-	HYPH
cord-022313-2675sjlf	103	13	P	p	NN
cord-022313-2675sjlf	103	14	-	-	HYPH
cord-022313-2675sjlf	103	15	mannose	mannose	NN
cord-022313-2675sjlf	103	16	(	(	-LRB-
cord-022313-2675sjlf	103	17	because	because	IN
cord-022313-2675sjlf	103	18	of	of	IN
cord-022313-2675sjlf	103	19	the	the	DT
cord-022313-2675sjlf	103	20	topology	topology	NN
cord-022313-2675sjlf	103	21	of	of	IN
cord-022313-2675sjlf	103	22	the	the	DT
cord-022313-2675sjlf	103	23	oligosac	oligosac	NNP
cord-022313-2675sjlf	103	24	charide	charide	NNP
cord-022313-2675sjlf	103	25	in	in	IN
cord-022313-2675sjlf	103	26	the	the	DT
cord-022313-2675sjlf	103	27	ER	ER	NNP
cord-022313-2675sjlf	103	28	lumen	lumen	NN
cord-022313-2675sjlf	103	29	and	and	CC
cord-022313-2675sjlf	103	30	the	the	DT
cord-022313-2675sjlf	103	31	results	result	NNS
cord-022313-2675sjlf	103	32	with	with	IN
cord-022313-2675sjlf	103	33	mutants	mutant	NNS
cord-022313-2675sjlf	103	34	missing	miss	VBG
cord-022313-2675sjlf	103	35	the	the	DT
cord-022313-2675sjlf	103	36	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	103	37	-	-	HYPH
cord-022313-2675sjlf	103	38	P	p	NN
cord-022313-2675sjlf	103	39	-	-	HYPH
cord-022313-2675sjlf	103	40	mannose	mannose	NN
cord-022313-2675sjlf	103	41	synthase	synthase	NN
cord-022313-2675sjlf	103	42	)	)	-RRB-
cord-022313-2675sjlf	103	43	(	(	-LRB-
cord-022313-2675sjlf	103	44	36	36	CD
cord-022313-2675sjlf	103	45	)	)	-RRB-
cord-022313-2675sjlf	103	46	,	,	,
cord-022313-2675sjlf	103	47	whereas	whereas	IN
cord-022313-2675sjlf	103	48	the	the	DT
cord-022313-2675sjlf	103	49	glucosyl	glucosyl	NNP
cord-022313-2675sjlf	103	50	donor	donor	NNP
cord-022313-2675sjlf	103	51	is	be	VBZ
cord-022313-2675sjlf	103	52	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	103	53	-	-	HYPH
cord-022313-2675sjlf	103	54	P	p	NN
cord-022313-2675sjlf	103	55	-	-	HYPH
cord-022313-2675sjlf	103	56	glucose	glucose	NN
cord-022313-2675sjlf	103	57	(	(	-LRB-
cord-022313-2675sjlf	103	58	45	45	CD
cord-022313-2675sjlf	103	59	)	)	-RRB-
cord-022313-2675sjlf	103	60	.	.	.
cord-022313-2675sjlf	104	1	Most	Most	JJS
cord-022313-2675sjlf	104	2	of	of	IN
cord-022313-2675sjlf	104	3	these	these	DT
cord-022313-2675sjlf	104	4	enzymes	enzyme	NNS
cord-022313-2675sjlf	104	5	have	have	VBP
cord-022313-2675sjlf	104	6	not	not	RB
cord-022313-2675sjlf	104	7	been	be	VBN
cord-022313-2675sjlf	104	8	isolated	isolate	VBN
cord-022313-2675sjlf	104	9	or	or	CC
cord-022313-2675sjlf	104	10	studied	study	VBN
cord-022313-2675sjlf	104	11	in	in	IN
cord-022313-2675sjlf	104	12	any	any	DT
cord-022313-2675sjlf	104	13	detail	detail	NN
cord-022313-2675sjlf	104	14	,	,	,
cord-022313-2675sjlf	104	15	and	and	CC
cord-022313-2675sjlf	104	16	therefore	therefore	RB
cord-022313-2675sjlf	104	17	little	little	JJ
cord-022313-2675sjlf	104	18	is	be	VBZ
cord-022313-2675sjlf	104	19	known	know	VBN
cord-022313-2675sjlf	104	20	about	about	IN
cord-022313-2675sjlf	104	21	their	-PRON-	PRP$
cord-022313-2675sjlf	104	22	properties	property	NNS
cord-022313-2675sjlf	104	23	.	.	.
cord-022313-2675sjlf	105	1	However	however	RB
cord-022313-2675sjlf	105	2	,	,	,
cord-022313-2675sjlf	105	3	the	the	DT
cord-022313-2675sjlf	105	4	enzyme	enzyme	NN
cord-022313-2675sjlf	105	5	that	that	WDT
cord-022313-2675sjlf	105	6	adds	add	VBZ
cord-022313-2675sjlf	105	7	the	the	DT
cord-022313-2675sjlf	105	8	first	first	JJ
cord-022313-2675sjlf	105	9	mannose	mannose	NN
cord-022313-2675sjlf	105	10	from	from	IN
cord-022313-2675sjlf	105	11	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	105	12	-	-	HYPH
cord-022313-2675sjlf	105	13	P	p	NN
cord-022313-2675sjlf	105	14	-	-	HYPH
cord-022313-2675sjlf	105	15	mannose	mannose	NN
cord-022313-2675sjlf	105	16	(	(	-LRB-
cord-022313-2675sjlf	105	17	i.e.	i.e.	FW
cord-022313-2675sjlf	105	18	,	,	,
cord-022313-2675sjlf	105	19	the	the	DT
cord-022313-2675sjlf	105	20	sixth	sixth	JJ
cord-022313-2675sjlf	105	21	mannose	mannose	NN
cord-022313-2675sjlf	105	22	to	to	IN
cord-022313-2675sjlf	105	23	the	the	DT
cord-022313-2675sjlf	105	24	lipid	lipid	NN
cord-022313-2675sjlf	105	25	)	)	-RRB-
cord-022313-2675sjlf	105	26	has	have	VBZ
cord-022313-2675sjlf	105	27	been	be	VBN
cord-022313-2675sjlf	105	28	par	par	NN
cord-022313-2675sjlf	105	29	tially	tially	RB
cord-022313-2675sjlf	105	30	purified	purify	VBN
cord-022313-2675sjlf	105	31	from	from	IN
cord-022313-2675sjlf	105	32	aorta	aorta	NN
cord-022313-2675sjlf	105	33	extracts	extract	NNS
cord-022313-2675sjlf	105	34	and	and	CC
cord-022313-2675sjlf	105	35	its	-PRON-	PRP$
cord-022313-2675sjlf	105	36	substrate	substrate	NN
cord-022313-2675sjlf	105	37	specificity	specificity	NN
cord-022313-2675sjlf	105	38	was	be	VBD
cord-022313-2675sjlf	105	39	determined	determine	VBN
cord-022313-2675sjlf	105	40	.	.	.
cord-022313-2675sjlf	106	1	For	for	IN
cord-022313-2675sjlf	106	2	activity	activity	NN
cord-022313-2675sjlf	106	3	,	,	,
cord-022313-2675sjlf	106	4	this	this	DT
cord-022313-2675sjlf	106	5	enzyme	enzyme	NN
cord-022313-2675sjlf	106	6	required	require	VBD
cord-022313-2675sjlf	106	7	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	106	8	-	-	HYPH
cord-022313-2675sjlf	106	9	P	p	NN
cord-022313-2675sjlf	106	10	-	-	HYPH
cord-022313-2675sjlf	106	11	mannose	mannose	NN
cord-022313-2675sjlf	106	12	as	as	IN
cord-022313-2675sjlf	106	13	the	the	DT
cord-022313-2675sjlf	106	14	mannosyl	mannosyl	NNP
cord-022313-2675sjlf	106	15	donor	donor	NN
cord-022313-2675sjlf	106	16	and	and	CC
cord-022313-2675sjlf	106	17	Man	Man	NNP
cord-022313-2675sjlf	106	18	5	5	CD
cord-022313-2675sjlf	106	19	(	(	-LRB-
cord-022313-2675sjlf	106	20	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	106	21	)	)	-RRB-
cord-022313-2675sjlf	106	22	2	2	CD
cord-022313-2675sjlf	106	23	-PP	-PP	NNS
cord-022313-2675sjlf	106	24	-	-	HYPH
cord-022313-2675sjlf	106	25	dolichol	dolichol	JJ
cord-022313-2675sjlf	106	26	as	as	IN
cord-022313-2675sjlf	106	27	the	the	DT
cord-022313-2675sjlf	106	28	mannosyl	mannosyl	NNP
cord-022313-2675sjlf	106	29	acceptor	acceptor	NN
cord-022313-2675sjlf	106	30	(	(	-LRB-
cord-022313-2675sjlf	106	31	46	46	CD
cord-022313-2675sjlf	106	32	)	)	-RRB-
cord-022313-2675sjlf	106	33	.	.	.
cord-022313-2675sjlf	107	1	Likewise	likewise	RB
cord-022313-2675sjlf	107	2	,	,	,
cord-022313-2675sjlf	107	3	the	the	DT
cord-022313-2675sjlf	107	4	enzyme	enzyme	NN
cord-022313-2675sjlf	107	5	that	that	WDT
cord-022313-2675sjlf	107	6	adds	add	VBZ
cord-022313-2675sjlf	107	7	the	the	DT
cord-022313-2675sjlf	107	8	first	first	JJ
cord-022313-2675sjlf	107	9	glucose	glucose	NN
cord-022313-2675sjlf	107	10	from	from	IN
cord-022313-2675sjlf	107	11	dolichyl	dolichyl	NN
cord-022313-2675sjlf	107	12	-	-	HYPH
cord-022313-2675sjlf	107	13	P	p	NN
cord-022313-2675sjlf	107	14	-	-	HYPH
cord-022313-2675sjlf	107	15	glucose	glucose	NN
cord-022313-2675sjlf	107	16	to	to	IN
cord-022313-2675sjlf	107	17	Man	Man	NNP
cord-022313-2675sjlf	107	18	9	9	CD
cord-022313-2675sjlf	107	19	(	(	-LRB-
cord-022313-2675sjlf	107	20	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	107	21	)	)	-RRB-
cord-022313-2675sjlf	107	22	2	2	CD
cord-022313-2675sjlf	107	23	-PP	-PP	NNS
cord-022313-2675sjlf	107	24	-	-	HYPH
cord-022313-2675sjlf	107	25	dolichol	dolichol	NNP
cord-022313-2675sjlf	107	26	was	be	VBD
cord-022313-2675sjlf	107	27	purified	purify	VBN
cord-022313-2675sjlf	107	28	to	to	IN
cord-022313-2675sjlf	107	29	near	near	IN
cord-022313-2675sjlf	107	30	homogeneity	homogeneity	NN
cord-022313-2675sjlf	107	31	from	from	IN
cord-022313-2675sjlf	107	32	pig	pig	NN
cord-022313-2675sjlf	107	33	aorta	aorta	NN
cord-022313-2675sjlf	107	34	and	and	CC
cord-022313-2675sjlf	107	35	its	-PRON-	PRP$
cord-022313-2675sjlf	107	36	substrate	substrate	NN
cord-022313-2675sjlf	107	37	specificity	specificity	NN
cord-022313-2675sjlf	107	38	and	and	CC
cord-022313-2675sjlf	108	1	oligosac	oligosac	NNP
cord-022313-2675sjlf	108	2	charide	charide	NNP
cord-022313-2675sjlf	108	3	acceptor	acceptor	NN
cord-022313-2675sjlf	108	4	specificity	specificity	NN
cord-022313-2675sjlf	108	5	were	be	VBD
cord-022313-2675sjlf	108	6	determined	determine	VBN
cord-022313-2675sjlf	108	7	.	.	.
cord-022313-2675sjlf	109	1	While	while	IN
cord-022313-2675sjlf	109	2	a	a	DT
cord-022313-2675sjlf	109	3	number	number	NN
cord-022313-2675sjlf	109	4	of	of	IN
cord-022313-2675sjlf	109	5	oligo	oligo	NN
cord-022313-2675sjlf	109	6	saccharide	saccharide	NN
cord-022313-2675sjlf	109	7	structures	structure	NNS
cord-022313-2675sjlf	109	8	linked	link	VBN
cord-022313-2675sjlf	109	9	to	to	IN
cord-022313-2675sjlf	109	10	dolichol	dolichol	NNP
cord-022313-2675sjlf	109	11	could	could	MD
cord-022313-2675sjlf	109	12	serve	serve	VB
cord-022313-2675sjlf	109	13	as	as	IN
cord-022313-2675sjlf	109	14	glucose	glucose	NN
cord-022313-2675sjlf	109	15	ac	ac	NNP
cord-022313-2675sjlf	109	16	ceptors	ceptor	NNS
cord-022313-2675sjlf	109	17	,	,	,
cord-022313-2675sjlf	109	18	they	-PRON-	PRP
cord-022313-2675sjlf	109	19	all	all	DT
cord-022313-2675sjlf	109	20	required	require	VBD
cord-022313-2675sjlf	109	21	the	the	DT
cord-022313-2675sjlf	109	22	Manal,2Manal,2Mana	manal,2manal,2mana	NN
cord-022313-2675sjlf	109	23	:	:	:
cord-022313-2675sjlf	110	1	l,3-branch	l,3-branch	NNP
cord-022313-2675sjlf	110	2	for	for	IN
cord-022313-2675sjlf	110	3	this	this	DT
cord-022313-2675sjlf	110	4	activity	activity	NN
cord-022313-2675sjlf	110	5	(	(	-LRB-
cord-022313-2675sjlf	110	6	47	47	CD
cord-022313-2675sjlf	110	7	)	)	-RRB-
cord-022313-2675sjlf	110	8	.	.	.
cord-022313-2675sjlf	111	1	The	the	DT
cord-022313-2675sjlf	111	2	enzyme(s	enzyme(s	NNP
cord-022313-2675sjlf	111	3	)	)	-RRB-
cord-022313-2675sjlf	111	4	that	that	WDT
cord-022313-2675sjlf	111	5	adds	add	VBZ
cord-022313-2675sjlf	111	6	the	the	DT
cord-022313-2675sjlf	111	7	last	last	JJ
cord-022313-2675sjlf	111	8	two	two	CD
cord-022313-2675sjlf	111	9	glucoses	glucose	NNS
cord-022313-2675sjlf	111	10	has	have	VBZ
cord-022313-2675sjlf	111	11	not	not	RB
cord-022313-2675sjlf	111	12	yet	yet	RB
cord-022313-2675sjlf	111	13	been	be	VBN
cord-022313-2675sjlf	111	14	purified	purify	VBN
cord-022313-2675sjlf	111	15	.	.	.
cord-022313-2675sjlf	112	1	The	the	DT
cord-022313-2675sjlf	112	2	role	role	NN
cord-022313-2675sjlf	112	3	of	of	IN
cord-022313-2675sjlf	112	4	the	the	DT
cord-022313-2675sjlf	112	5	glucose	glucose	NN
cord-022313-2675sjlf	112	6	units	unit	NNS
cord-022313-2675sjlf	112	7	in	in	IN
cord-022313-2675sjlf	112	8	the	the	DT
cord-022313-2675sjlf	112	9	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	112	10	of	of	IN
cord-022313-2675sjlf	112	11	N	N	NNP
cord-022313-2675sjlf	112	12	-	-	HYPH
cord-022313-2675sjlf	112	13	linked	link	VBN
cord-022313-2675sjlf	112	14	oligosac	oligosac	NNP
cord-022313-2675sjlf	112	15	charides	charides	NNP
cord-022313-2675sjlf	112	16	is	be	VBZ
cord-022313-2675sjlf	112	17	presumably	presumably	RB
cord-022313-2675sjlf	112	18	to	to	TO
cord-022313-2675sjlf	112	19	facilitate	facilitate	VB
cord-022313-2675sjlf	112	20	the	the	DT
cord-022313-2675sjlf	112	21	transfer	transfer	NN
cord-022313-2675sjlf	112	22	of	of	IN
cord-022313-2675sjlf	112	23	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	112	24	from	from	IN
cord-022313-2675sjlf	112	25	lipid	lipid	NN
cord-022313-2675sjlf	112	26	to	to	IN
cord-022313-2675sjlf	112	27	protein	protein	NN
cord-022313-2675sjlf	112	28	.	.	.
cord-022313-2675sjlf	113	1	That	that	RB
cord-022313-2675sjlf	113	2	is	is	RB
cord-022313-2675sjlf	113	3	,	,	,
cord-022313-2675sjlf	113	4	the	the	DT
cord-022313-2675sjlf	113	5	oligosaccharyltransferase	oligosaccharyltransferase	NN
cord-022313-2675sjlf	113	6	that	that	WDT
cord-022313-2675sjlf	113	7	catalyzes	catalyze	VBZ
cord-022313-2675sjlf	113	8	this	this	DT
cord-022313-2675sjlf	113	9	final	final	JJ
cord-022313-2675sjlf	113	10	step	step	NN
cord-022313-2675sjlf	113	11	in	in	IN
cord-022313-2675sjlf	113	12	the	the	DT
cord-022313-2675sjlf	113	13	dolichol	dolichol	NNP
cord-022313-2675sjlf	113	14	cycle	cycle	NN
cord-022313-2675sjlf	113	15	recognizes	recognize	VBZ
cord-022313-2675sjlf	113	16	or	or	CC
cord-022313-2675sjlf	113	17	prefers	prefer	VBZ
cord-022313-2675sjlf	113	18	glucosecontaining	glucosecontaine	VBG
cord-022313-2675sjlf	113	19	lipid	lipid	NN
cord-022313-2675sjlf	113	20	-	-	HYPH
cord-022313-2675sjlf	113	21	linked	link	VBN
cord-022313-2675sjlf	113	22	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	113	23	as	as	IN
cord-022313-2675sjlf	113	24	the	the	DT
cord-022313-2675sjlf	113	25	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	113	26	donor	donor	NN
cord-022313-2675sjlf	113	27	(	(	-LRB-
cord-022313-2675sjlf	113	28	48	48	CD
cord-022313-2675sjlf	113	29	,	,	,
cord-022313-2675sjlf	113	30	49	49	CD
cord-022313-2675sjlf	113	31	)	)	-RRB-
cord-022313-2675sjlf	113	32	.	.	.
cord-022313-2675sjlf	114	1	In	in	IN
cord-022313-2675sjlf	114	2	fact	fact	NN
cord-022313-2675sjlf	114	3	,	,	,
cord-022313-2675sjlf	114	4	studies	study	NNS
cord-022313-2675sjlf	114	5	with	with	IN
cord-022313-2675sjlf	114	6	microsomes	microsome	NNS
cord-022313-2675sjlf	114	7	showed	show	VBD
cord-022313-2675sjlf	114	8	that	that	IN
cord-022313-2675sjlf	114	9	glucosecontaining	glucosecontaine	VBG
cord-022313-2675sjlf	114	10	lipid	lipid	NN
cord-022313-2675sjlf	114	11	-	-	HYPH
cord-022313-2675sjlf	114	12	linked	link	VBN
cord-022313-2675sjlf	114	13	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	114	14	were	be	VBD
cord-022313-2675sjlf	114	15	much	much	RB
cord-022313-2675sjlf	114	16	more	more	RBR
cord-022313-2675sjlf	114	17	efficient	efficient	JJ
cord-022313-2675sjlf	114	18	oli	oli	NNP
cord-022313-2675sjlf	114	19	gosaccharide	gosaccharide	NN
cord-022313-2675sjlf	114	20	donors	donor	NNS
cord-022313-2675sjlf	114	21	than	than	IN
cord-022313-2675sjlf	114	22	were	be	VBD
cord-022313-2675sjlf	114	23	glucose	glucose	NN
cord-022313-2675sjlf	114	24	-	-	HYPH
cord-022313-2675sjlf	114	25	free	free	JJ
cord-022313-2675sjlf	114	26	lipid	lipid	NN
cord-022313-2675sjlf	114	27	-	-	HYPH
cord-022313-2675sjlf	114	28	linked	link	VBN
cord-022313-2675sjlf	114	29	oligosaccha	oligosaccha	NN
cord-022313-2675sjlf	114	30	rides	ride	NNS
cord-022313-2675sjlf	114	31	.	.	.
cord-022313-2675sjlf	115	1	Thus	thus	RB
cord-022313-2675sjlf	115	2	,	,	,
cord-022313-2675sjlf	115	3	this	this	DT
cord-022313-2675sjlf	115	4	last	last	JJ
cord-022313-2675sjlf	115	5	step	step	NN
cord-022313-2675sjlf	115	6	of	of	IN
cord-022313-2675sjlf	115	7	the	the	DT
cord-022313-2675sjlf	115	8	dolichol	dolichol	NNP
cord-022313-2675sjlf	115	9	cycle	cycle	NN
cord-022313-2675sjlf	115	10	occurs	occur	VBZ
cord-022313-2675sjlf	115	11	in	in	IN
cord-022313-2675sjlf	115	12	the	the	DT
cord-022313-2675sjlf	115	13	ER	er	NN
cord-022313-2675sjlf	115	14	and	and	CC
cord-022313-2675sjlf	115	15	the	the	DT
cord-022313-2675sjlf	115	16	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	115	17	is	be	VBZ
cord-022313-2675sjlf	115	18	transferred	transfer	VBN
cord-022313-2675sjlf	115	19	to	to	IN
cord-022313-2675sjlf	115	20	specific	specific	JJ
cord-022313-2675sjlf	115	21	asparagine	asparagine	NN
cord-022313-2675sjlf	115	22	residues	residue	NNS
cord-022313-2675sjlf	115	23	on	on	IN
cord-022313-2675sjlf	115	24	the	the	DT
cord-022313-2675sjlf	115	25	protein	protein	NN
cord-022313-2675sjlf	115	26	,	,	,
cord-022313-2675sjlf	115	27	as	as	IN
cord-022313-2675sjlf	115	28	the	the	DT
cord-022313-2675sjlf	115	29	polypeptide	polypeptide	NN
cord-022313-2675sjlf	115	30	is	be	VBZ
cord-022313-2675sjlf	115	31	being	be	VBG
cord-022313-2675sjlf	115	32	elongated	elongated	JJ
cord-022313-2675sjlf	115	33	on	on	IN
cord-022313-2675sjlf	115	34	ER	ER	NNP
cord-022313-2675sjlf	115	35	-	-	HYPH
cord-022313-2675sjlf	115	36	bound	bind	VBN
cord-022313-2675sjlf	115	37	poly	poly	NNP
cord-022313-2675sjlf	115	38	somes	some	NNS
cord-022313-2675sjlf	115	39	(	(	-LRB-
cord-022313-2675sjlf	115	40	50	50	CD
cord-022313-2675sjlf	115	41	)	)	-RRB-
cord-022313-2675sjlf	115	42	.	.	.
cord-022313-2675sjlf	116	1	The	the	DT
cord-022313-2675sjlf	116	2	oligosaccharyltransferase	oligosaccharyltransferase	NN
cord-022313-2675sjlf	116	3	has	have	VBZ
cord-022313-2675sjlf	116	4	recently	recently	RB
cord-022313-2675sjlf	116	5	been	be	VBN
cord-022313-2675sjlf	116	6	purified	purify	VBN
cord-022313-2675sjlf	116	7	to	to	IN
cord-022313-2675sjlf	116	8	apparant	apparant	JJ
cord-022313-2675sjlf	116	9	homogeneity	homogeneity	NN
cord-022313-2675sjlf	116	10	from	from	IN
cord-022313-2675sjlf	116	11	liver	liver	NN
cord-022313-2675sjlf	116	12	(	(	-LRB-
cord-022313-2675sjlf	116	13	51	51	CD
cord-022313-2675sjlf	116	14	)	)	-RRB-
cord-022313-2675sjlf	116	15	.	.	.
cord-022313-2675sjlf	117	1	Once	once	RB
cord-022313-2675sjlf	117	2	the	the	DT
cord-022313-2675sjlf	117	3	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	117	4	chain(s	chain(s	NNP
cord-022313-2675sjlf	117	5	)	)	-RRB-
cord-022313-2675sjlf	117	6	is	be	VBZ
cord-022313-2675sjlf	117	7	transferred	transfer	VBN
cord-022313-2675sjlf	117	8	to	to	IN
cord-022313-2675sjlf	117	9	the	the	DT
cord-022313-2675sjlf	117	10	protein	protein	NN
cord-022313-2675sjlf	117	11	,	,	,
cord-022313-2675sjlf	117	12	and	and	CC
cord-022313-2675sjlf	117	13	while	while	IN
cord-022313-2675sjlf	117	14	the	the	DT
cord-022313-2675sjlf	117	15	protein	protein	NN
cord-022313-2675sjlf	117	16	is	be	VBZ
cord-022313-2675sjlf	117	17	still	still	RB
cord-022313-2675sjlf	117	18	undergoing	undergo	VBG
cord-022313-2675sjlf	117	19	synthesis	synthesis	NN
cord-022313-2675sjlf	117	20	in	in	IN
cord-022313-2675sjlf	117	21	the	the	DT
cord-022313-2675sjlf	117	22	ER	ER	NNP
cord-022313-2675sjlf	117	23	,	,	,
cord-022313-2675sjlf	117	24	two	two	CD
cord-022313-2675sjlf	117	25	membrane	membrane	NN
cord-022313-2675sjlf	117	26	-	-	HYPH
cord-022313-2675sjlf	117	27	bound	bind	VBN
cord-022313-2675sjlf	117	28	and	and	CC
cord-022313-2675sjlf	117	29	highly	highly	RB
cord-022313-2675sjlf	117	30	specific	specific	JJ
cord-022313-2675sjlf	117	31	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	117	32	remove	remove	VBP
cord-022313-2675sjlf	117	33	all	all	DT
cord-022313-2675sjlf	117	34	three	three	CD
cord-022313-2675sjlf	117	35	glucoses	glucose	NNS
cord-022313-2675sjlf	117	36	from	from	IN
cord-022313-2675sjlf	117	37	the	the	DT
cord-022313-2675sjlf	117	38	Glc	Glc	NNP
cord-022313-2675sjlf	117	39	3	3	CD
cord-022313-2675sjlf	117	40	Man	Man	NNP
cord-022313-2675sjlf	117	41	9	9	CD
cord-022313-2675sjlf	117	42	(	(	-LRB-
cord-022313-2675sjlf	117	43	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	117	44	)	)	-RRB-
cord-022313-2675sjlf	117	45	2	2	CD
cord-022313-2675sjlf	117	46	.	.	.
cord-022313-2675sjlf	118	1	The	the	DT
cord-022313-2675sjlf	118	2	processing	processing	NN
cord-022313-2675sjlf	118	3	pathway	pathway	NN
cord-022313-2675sjlf	118	4	for	for	IN
cord-022313-2675sjlf	118	5	re	re	VBG
cord-022313-2675sjlf	118	6	linked	link	VBN
cord-022313-2675sjlf	118	7	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	118	8	is	be	VBZ
cord-022313-2675sjlf	118	9	outlined	outline	VBN
cord-022313-2675sjlf	118	10	in	in	IN
cord-022313-2675sjlf	118	11	Fig	Fig	NNP
cord-022313-2675sjlf	118	12	.	.	.
cord-022313-2675sjlf	119	1	3	3	LS
cord-022313-2675sjlf	119	2	.	.	.
cord-022313-2675sjlf	120	1	Thus	thus	RB
cord-022313-2675sjlf	120	2	,	,	,
cord-022313-2675sjlf	120	3	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	121	1	I	-PRON-	PRP
cord-022313-2675sjlf	121	2	re	re	VBP
cord-022313-2675sjlf	121	3	moves	move	NNS
cord-022313-2675sjlf	121	4	the	the	DT
cord-022313-2675sjlf	121	5	outermost	outermost	JJS
cord-022313-2675sjlf	121	6	al,2-linked	al,2-linked	JJ
cord-022313-2675sjlf	121	7	glucose	glucose	NN
cord-022313-2675sjlf	121	8	to	to	TO
cord-022313-2675sjlf	121	9	give	give	VB
cord-022313-2675sjlf	121	10	a	a	DT
cord-022313-2675sjlf	121	11	Glc	Glc	NNP
cord-022313-2675sjlf	121	12	2	2	CD
cord-022313-2675sjlf	121	13	Man	man	NN
cord-022313-2675sjlf	121	14	9	9	CD
cord-022313-2675sjlf	121	15	(	(	-LRB-
cord-022313-2675sjlf	121	16	Glc	Glc	NNP
cord-022313-2675sjlf	121	17	-	-	HYPH
cord-022313-2675sjlf	121	18	NAc	NAc	NNP
cord-022313-2675sjlf	121	19	)	)	-RRB-
cord-022313-2675sjlf	121	20	2	2	CD
cord-022313-2675sjlf	121	21	-protein	-protein	CC
cord-022313-2675sjlf	121	22	(	(	-LRB-
cord-022313-2675sjlf	121	23	52	52	CD
cord-022313-2675sjlf	121	24	)	)	-RRB-
cord-022313-2675sjlf	121	25	,	,	,
cord-022313-2675sjlf	121	26	whereas	whereas	IN
cord-022313-2675sjlf	121	27	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	121	28	II	II	NNP
cord-022313-2675sjlf	121	29	removes	remove	VBZ
cord-022313-2675sjlf	121	30	the	the	DT
cord-022313-2675sjlf	121	31	next	next	JJ
cord-022313-2675sjlf	121	32	two	two	CD
cord-022313-2675sjlf	121	33	al,3-linked	al,3-linked	NNP
cord-022313-2675sjlf	121	34	glucoses	glucose	NNS
cord-022313-2675sjlf	121	35	to	to	TO
cord-022313-2675sjlf	121	36	give	give	VB
cord-022313-2675sjlf	121	37	the	the	DT
cord-022313-2675sjlf	121	38	Man	man	NN
cord-022313-2675sjlf	121	39	9	9	CD
cord-022313-2675sjlf	121	40	(	(	-LRB-
cord-022313-2675sjlf	121	41	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	121	42	)	)	-RRB-
cord-022313-2675sjlf	121	43	2	2	CD
cord-022313-2675sjlf	121	44	-protein	-protein	CC
cord-022313-2675sjlf	121	45	(	(	-LRB-
cord-022313-2675sjlf	121	46	53	53	CD
cord-022313-2675sjlf	121	47	)	)	-RRB-
cord-022313-2675sjlf	121	48	.	.	.
cord-022313-2675sjlf	122	1	Glucosi	Glucosi	NNP
cord-022313-2675sjlf	122	2	dase	dase	NNP
cord-022313-2675sjlf	123	1	I	-PRON-	PRP
cord-022313-2675sjlf	123	2	has	have	VBZ
cord-022313-2675sjlf	123	3	been	be	VBN
cord-022313-2675sjlf	123	4	purified	purify	VBN
cord-022313-2675sjlf	123	5	from	from	IN
cord-022313-2675sjlf	123	6	calf	calf	NN
cord-022313-2675sjlf	123	7	(	(	-LRB-
cord-022313-2675sjlf	123	8	54	54	CD
cord-022313-2675sjlf	123	9	)	)	-RRB-
cord-022313-2675sjlf	123	10	and	and	CC
cord-022313-2675sjlf	123	11	porcine	porcine	JJ
cord-022313-2675sjlf	123	12	(	(	-LRB-
cord-022313-2675sjlf	123	13	55	55	CD
cord-022313-2675sjlf	123	14	)	)	-RRB-
cord-022313-2675sjlf	123	15	liver	liver	NN
cord-022313-2675sjlf	123	16	,	,	,
cord-022313-2675sjlf	123	17	from	from	IN
cord-022313-2675sjlf	123	18	bovine	bovine	JJ
cord-022313-2675sjlf	123	19	mammary	mammary	JJ
cord-022313-2675sjlf	123	20	glands	gland	NNS
cord-022313-2675sjlf	123	21	(	(	-LRB-
cord-022313-2675sjlf	123	22	56	56	CD
cord-022313-2675sjlf	123	23	)	)	-RRB-
cord-022313-2675sjlf	123	24	,	,	,
cord-022313-2675sjlf	123	25	from	from	IN
cord-022313-2675sjlf	123	26	mung	mung	NN
cord-022313-2675sjlf	123	27	bean	bean	NN
cord-022313-2675sjlf	123	28	seedlings	seedling	NNS
cord-022313-2675sjlf	123	29	(	(	-LRB-
cord-022313-2675sjlf	123	30	57	57	CD
cord-022313-2675sjlf	123	31	)	)	-RRB-
cord-022313-2675sjlf	123	32	,	,	,
cord-022313-2675sjlf	123	33	and	and	CC
cord-022313-2675sjlf	123	34	from	from	IN
cord-022313-2675sjlf	123	35	Saccharomyces	Saccharomyces	NNP
cord-022313-2675sjlf	123	36	cerevesiae	cerevesiae	NNP
cord-022313-2675sjlf	123	37	(	(	-LRB-
cord-022313-2675sjlf	123	38	58	58	CD
cord-022313-2675sjlf	123	39	)	)	-RRB-
cord-022313-2675sjlf	123	40	.	.	.
cord-022313-2675sjlf	124	1	This	this	DT
cord-022313-2675sjlf	124	2	enzyme	enzyme	NN
cord-022313-2675sjlf	124	3	has	have	VBZ
cord-022313-2675sjlf	124	4	a	a	DT
cord-022313-2675sjlf	124	5	pH	pH	NNP
cord-022313-2675sjlf	124	6	optimum	optimum	NN
cord-022313-2675sjlf	124	7	in	in	IN
cord-022313-2675sjlf	124	8	the	the	DT
cord-022313-2675sjlf	124	9	neutral	neutral	JJ
cord-022313-2675sjlf	124	10	range	range	NN
cord-022313-2675sjlf	124	11	(	(	-LRB-
cord-022313-2675sjlf	124	12	6.4	6.4	CD
cord-022313-2675sjlf	124	13	-	-	SYM
cord-022313-2675sjlf	124	14	6.8	6.8	CD
cord-022313-2675sjlf	124	15	)	)	-RRB-
cord-022313-2675sjlf	124	16	,	,	,
cord-022313-2675sjlf	124	17	does	do	VBZ
cord-022313-2675sjlf	124	18	not	not	RB
cord-022313-2675sjlf	124	19	work	work	VB
cord-022313-2675sjlf	124	20	with	with	IN
cord-022313-2675sjlf	124	21	p	p	NN
cord-022313-2675sjlf	124	22	-	-	HYPH
cord-022313-2675sjlf	124	23	nitrophenyl	nitrophenyl	NN
cord-022313-2675sjlf	124	24	-	-	HYPH
cord-022313-2675sjlf	124	25	a	a	DT
cord-022313-2675sjlf	124	26	-	-	HYPH
cord-022313-2675sjlf	124	27	D	d	NN
cord-022313-2675sjlf	124	28	-	-	HYPH
cord-022313-2675sjlf	124	29	glucopyranoside	glucopyranoside	NN
cord-022313-2675sjlf	124	30	,	,	,
cord-022313-2675sjlf	124	31	and	and	CC
cord-022313-2675sjlf	124	32	is	be	VBZ
cord-022313-2675sjlf	124	33	quite	quite	RB
cord-022313-2675sjlf	124	34	specific	specific	JJ
cord-022313-2675sjlf	124	35	for	for	IN
cord-022313-2675sjlf	124	36	al,2-glucosidic	al,2-glucosidic	JJ
cord-022313-2675sjlf	124	37	linkages	linkage	NNS
cord-022313-2675sjlf	124	38	.	.	.
cord-022313-2675sjlf	125	1	The	the	DT
cord-022313-2675sjlf	125	2	mam	mam	NN
cord-022313-2675sjlf	125	3	malian	malian	JJ
cord-022313-2675sjlf	125	4	enzyme	enzyme	NN
cord-022313-2675sjlf	125	5	is	be	VBZ
cord-022313-2675sjlf	125	6	a	a	DT
cord-022313-2675sjlf	125	7	tetramer	tetramer	NN
cord-022313-2675sjlf	125	8	with	with	IN
cord-022313-2675sjlf	125	9	subunits	subunit	NNS
cord-022313-2675sjlf	125	10	of	of	IN
cord-022313-2675sjlf	125	11	about	about	RB
cord-022313-2675sjlf	125	12	85	85	CD
cord-022313-2675sjlf	125	13	kDa	kDa	NNS
cord-022313-2675sjlf	125	14	,	,	,
cord-022313-2675sjlf	125	15	whereas	whereas	IN
cord-022313-2675sjlf	125	16	the	the	DT
cord-022313-2675sjlf	125	17	yeast	yeast	NN
cord-022313-2675sjlf	125	18	enzyme	enzyme	NN
cord-022313-2675sjlf	125	19	has	have	VBZ
cord-022313-2675sjlf	125	20	subunits	subunit	NNS
cord-022313-2675sjlf	125	21	of	of	IN
cord-022313-2675sjlf	125	22	about	about	RB
cord-022313-2675sjlf	125	23	95	95	CD
cord-022313-2675sjlf	125	24	kDa	kDa	NNS
cord-022313-2675sjlf	125	25	.	.	.
cord-022313-2675sjlf	126	1	In	in	IN
cord-022313-2675sjlf	126	2	S.	S.	NNP
cord-022313-2675sjlf	126	3	cerevesiae	cerevesiae	NNS
cord-022313-2675sjlf	126	4	,	,	,
cord-022313-2675sjlf	126	5	the	the	DT
cord-022313-2675sjlf	126	6	glsl	glsl	NNP
cord-022313-2675sjlf	126	7	mutation	mutation	NN
cord-022313-2675sjlf	126	8	results	result	NNS
cord-022313-2675sjlf	126	9	in	in	IN
cord-022313-2675sjlf	126	10	cells	cell	NNS
cord-022313-2675sjlf	126	11	that	that	WDT
cord-022313-2675sjlf	126	12	lack	lack	VBP
cord-022313-2675sjlf	126	13	glucosidase	glucosidase	NN
cord-022313-2675sjlf	126	14	I	i	NN
cord-022313-2675sjlf	126	15	and	and	CC
cord-022313-2675sjlf	126	16	produce	produce	VB
cord-022313-2675sjlf	126	17	glyco	glyco	NNP
cord-022313-2675sjlf	126	18	proteins	protein	NNS
cord-022313-2675sjlf	126	19	that	that	WDT
cord-022313-2675sjlf	126	20	maintain	maintain	VBP
cord-022313-2675sjlf	126	21	the	the	DT
cord-022313-2675sjlf	126	22	Glc	Glc	NNP
cord-022313-2675sjlf	126	23	3	3	CD
cord-022313-2675sjlf	126	24	Man	Man	NNP
cord-022313-2675sjlf	126	25	9	9	CD
cord-022313-2675sjlf	126	26	(	(	-LRB-
cord-022313-2675sjlf	126	27	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	126	28	)	)	-RRB-
cord-022313-2675sjlf	126	29	2	2	CD
cord-022313-2675sjlf	126	30	structure	structure	NN
cord-022313-2675sjlf	126	31	(	(	-LRB-
cord-022313-2675sjlf	126	32	59	59	CD
cord-022313-2675sjlf	126	33	)	)	-RRB-
cord-022313-2675sjlf	126	34	.	.	.
cord-022313-2675sjlf	127	1	How	how	WRB
cord-022313-2675sjlf	127	2	ever	ever	RB
cord-022313-2675sjlf	127	3	,	,	,
cord-022313-2675sjlf	127	4	this	this	DT
cord-022313-2675sjlf	127	5	alteration	alteration	NN
cord-022313-2675sjlf	127	6	in	in	IN
cord-022313-2675sjlf	127	7	structure	structure	NN
cord-022313-2675sjlf	127	8	has	have	VBZ
cord-022313-2675sjlf	127	9	no	no	DT
cord-022313-2675sjlf	127	10	effect	effect	NN
cord-022313-2675sjlf	127	11	on	on	IN
cord-022313-2675sjlf	127	12	secretion	secretion	NN
cord-022313-2675sjlf	127	13	of	of	IN
cord-022313-2675sjlf	127	14	the	the	DT
cord-022313-2675sjlf	127	15	glyco	glyco	NNP
cord-022313-2675sjlf	127	16	proteins	protein	NNS
cord-022313-2675sjlf	127	17	,	,	,
cord-022313-2675sjlf	127	18	in	in	IN
cord-022313-2675sjlf	127	19	contrast	contrast	NN
cord-022313-2675sjlf	127	20	to	to	IN
cord-022313-2675sjlf	127	21	mammalian	mammalian	JJ
cord-022313-2675sjlf	127	22	cells	cell	NNS
cord-022313-2675sjlf	127	23	in	in	IN
cord-022313-2675sjlf	127	24	which	which	WDT
cord-022313-2675sjlf	127	25	such	such	PDT
cord-022313-2675sjlf	127	26	an	an	DT
cord-022313-2675sjlf	127	27	alteration	alteration	NN
cord-022313-2675sjlf	127	28	had	have	VBD
cord-022313-2675sjlf	127	29	profound	profound	JJ
cord-022313-2675sjlf	127	30	effects	effect	NNS
cord-022313-2675sjlf	127	31	(	(	-LRB-
cord-022313-2675sjlf	127	32	see	see	VB
cord-022313-2675sjlf	127	33	section	section	NN
cord-022313-2675sjlf	127	34	on	on	IN
cord-022313-2675sjlf	127	35	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	127	36	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	127	37	)	)	-RRB-
cord-022313-2675sjlf	127	38	.	.	.
cord-022313-2675sjlf	128	1	A	a	DT
cord-022313-2675sjlf	128	2	CHO	CHO	NNP
cord-022313-2675sjlf	128	3	mutant	mutant	JJ
cord-022313-2675sjlf	128	4	cell	cell	NN
cord-022313-2675sjlf	128	5	line	line	NN
cord-022313-2675sjlf	128	6	has	have	VBZ
cord-022313-2675sjlf	128	7	been	be	VBN
cord-022313-2675sjlf	128	8	isolated	isolate	VBN
cord-022313-2675sjlf	128	9	by	by	IN
cord-022313-2675sjlf	128	10	virtue	virtue	NN
cord-022313-2675sjlf	128	11	of	of	IN
cord-022313-2675sjlf	128	12	its	-PRON-	PRP$
cord-022313-2675sjlf	128	13	resistance	resistance	NN
cord-022313-2675sjlf	128	14	to	to	IN
cord-022313-2675sjlf	128	15	L	L	NNP
cord-022313-2675sjlf	128	16	-	-	HYPH
cord-022313-2675sjlf	128	17	PHA	PHA	NNP
cord-022313-2675sjlf	128	18	,	,	,
cord-022313-2675sjlf	128	19	and	and	CC
cord-022313-2675sjlf	128	20	this	this	DT
cord-022313-2675sjlf	128	21	mutant	mutant	JJ
cord-022313-2675sjlf	128	22	cell	cell	NN
cord-022313-2675sjlf	128	23	,	,	,
cord-022313-2675sjlf	128	24	called	call	VBN
cord-022313-2675sjlf	128	25	Lec23	Lec23	NNP
cord-022313-2675sjlf	128	26	,	,	,
cord-022313-2675sjlf	128	27	has	have	VBZ
cord-022313-2675sjlf	128	28	been	be	VBN
cord-022313-2675sjlf	128	29	shown	show	VBN
cord-022313-2675sjlf	128	30	to	to	IN
cord-022313-2675sjlf	128	31	lack	lack	JJ
cord-022313-2675sjlf	128	32	glucosidase	glucosidase	NN
cord-022313-2675sjlf	129	1	I	-PRON-	PRP
cord-022313-2675sjlf	129	2	(	(	-LRB-
cord-022313-2675sjlf	129	3	60	60	CD
cord-022313-2675sjlf	129	4	)	)	-RRB-
cord-022313-2675sjlf	129	5	.	.	.
cord-022313-2675sjlf	130	1	These	these	DT
cord-022313-2675sjlf	130	2	cells	cell	NNS
cord-022313-2675sjlf	130	3	were	be	VBD
cord-022313-2675sjlf	130	4	found	find	VBN
cord-022313-2675sjlf	130	5	to	to	TO
cord-022313-2675sjlf	130	6	synthesize	synthesize	VB
cord-022313-2675sjlf	130	7	the	the	DT
cord-022313-2675sjlf	130	8	G	g	NN
cord-022313-2675sjlf	130	9	protein	protein	NN
cord-022313-2675sjlf	130	10	of	of	IN
cord-022313-2675sjlf	130	11	VSV	VSV	NNP
cord-022313-2675sjlf	130	12	having	have	VBG
cord-022313-2675sjlf	130	13	hybrid	hybrid	JJ
cord-022313-2675sjlf	130	14	and	and	CC
cord-022313-2675sjlf	130	15	high	high	JJ
cord-022313-2675sjlf	130	16	-	-	HYPH
cord-022313-2675sjlf	130	17	mannose	mannose	NN
cord-022313-2675sjlf	130	18	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	130	19	,	,	,
cord-022313-2675sjlf	130	20	as	as	RB
cord-022313-2675sjlf	130	21	well	well	RB
cord-022313-2675sjlf	130	22	as	as	IN
cord-022313-2675sjlf	130	23	complex	complex	JJ
cord-022313-2675sjlf	130	24	chains	chain	NNS
cord-022313-2675sjlf	130	25	.	.	.
cord-022313-2675sjlf	131	1	Glucosidase	Glucosidase	NNP
cord-022313-2675sjlf	131	2	II	II	NNP
cord-022313-2675sjlf	131	3	was	be	VBD
cord-022313-2675sjlf	131	4	initially	initially	RB
cord-022313-2675sjlf	131	5	identified	identify	VBN
cord-022313-2675sjlf	131	6	in	in	IN
cord-022313-2675sjlf	131	7	microsomal	microsomal	NNP
cord-022313-2675sjlf	131	8	fractions	fraction	NNS
cord-022313-2675sjlf	131	9	of	of	IN
cord-022313-2675sjlf	131	10	rat	rat	NN
cord-022313-2675sjlf	131	11	liver	liver	NN
cord-022313-2675sjlf	131	12	(	(	-LRB-
cord-022313-2675sjlf	131	13	61	61	CD
cord-022313-2675sjlf	131	14	)	)	-RRB-
cord-022313-2675sjlf	131	15	,	,	,
cord-022313-2675sjlf	131	16	calf	calf	NN
cord-022313-2675sjlf	131	17	liver	liver	NN
cord-022313-2675sjlf	131	18	(	(	-LRB-
cord-022313-2675sjlf	131	19	62	62	CD
cord-022313-2675sjlf	131	20	)	)	-RRB-
cord-022313-2675sjlf	131	21	,	,	,
cord-022313-2675sjlf	131	22	and	and	CC
cord-022313-2675sjlf	131	23	yeast	yeast	NN
cord-022313-2675sjlf	131	24	(	(	-LRB-
cord-022313-2675sjlf	131	25	63	63	CD
cord-022313-2675sjlf	131	26	)	)	-RRB-
cord-022313-2675sjlf	131	27	and	and	CC
cord-022313-2675sjlf	131	28	was	be	VBD
cord-022313-2675sjlf	131	29	shown	show	VBN
cord-022313-2675sjlf	131	30	to	to	TO
cord-022313-2675sjlf	131	31	re	re	VB
cord-022313-2675sjlf	131	32	move	move	VB
cord-022313-2675sjlf	131	33	both	both	DT
cord-022313-2675sjlf	131	34	of	of	IN
cord-022313-2675sjlf	131	35	the	the	DT
cord-022313-2675sjlf	131	36	al,3-linked	al,3-linked	NNP
cord-022313-2675sjlf	131	37	glucoses	glucose	NNS
cord-022313-2675sjlf	131	38	from	from	IN
cord-022313-2675sjlf	131	39	Glc	Glc	NNP
cord-022313-2675sjlf	131	40	2	2	CD
cord-022313-2675sjlf	131	41	Man	Man	NNP
cord-022313-2675sjlf	131	42	9	9	CD
cord-022313-2675sjlf	131	43	(	(	-LRB-
cord-022313-2675sjlf	131	44	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	131	45	)	)	-RRB-
cord-022313-2675sjlf	131	46	2	2	CD
cord-022313-2675sjlf	131	47	to	to	TO
cord-022313-2675sjlf	131	48	form	form	VB
cord-022313-2675sjlf	131	49	Man	Man	NNP
cord-022313-2675sjlf	131	50	9	9	CD
cord-022313-2675sjlf	131	51	(	(	-LRB-
cord-022313-2675sjlf	131	52	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	131	53	)	)	-RRB-
cord-022313-2675sjlf	131	54	2	2	CD
cord-022313-2675sjlf	131	55	.	.	.
cord-022313-2675sjlf	132	1	However	however	RB
cord-022313-2675sjlf	132	2	,	,	,
cord-022313-2675sjlf	132	3	removal	removal	NN
cord-022313-2675sjlf	132	4	of	of	IN
cord-022313-2675sjlf	132	5	the	the	DT
cord-022313-2675sjlf	132	6	outermost	outermost	JJ
cord-022313-2675sjlf	132	7	al,3-linked	al,3-linked	JJ
cord-022313-2675sjlf	132	8	glucose	glucose	NN
cord-022313-2675sjlf	132	9	is	be	VBZ
cord-022313-2675sjlf	132	10	quite	quite	RB
cord-022313-2675sjlf	132	11	rapid	rapid	JJ
cord-022313-2675sjlf	132	12	(	(	-LRB-
cord-022313-2675sjlf	132	13	£	£	$
cord-022313-2675sjlf	132	14	1/2	1/2	CD
cord-022313-2675sjlf	132	15	=	=	SYM
cord-022313-2675sjlf	132	16	5	5	CD
cord-022313-2675sjlf	132	17	min	min	NNP
cord-022313-2675sjlf	132	18	)	)	-RRB-
cord-022313-2675sjlf	132	19	as	as	IN
cord-022313-2675sjlf	132	20	compared	compare	VBN
cord-022313-2675sjlf	132	21	with	with	IN
cord-022313-2675sjlf	132	22	cleavage	cleavage	NN
cord-022313-2675sjlf	132	23	of	of	IN
cord-022313-2675sjlf	132	24	the	the	DT
cord-022313-2675sjlf	132	25	innermost	innermost	JJ
cord-022313-2675sjlf	132	26	glucose	glucose	NN
cord-022313-2675sjlf	132	27	(	(	-LRB-
cord-022313-2675sjlf	132	28	t	t	NN
cord-022313-2675sjlf	132	29	1/2	1/2	CD
cord-022313-2675sjlf	132	30	=	=	SYM
cord-022313-2675sjlf	132	31	20	20	CD
cord-022313-2675sjlf	132	32	-	-	SYM
cord-022313-2675sjlf	132	33	30	30	CD
cord-022313-2675sjlf	132	34	min	min	NN
cord-022313-2675sjlf	132	35	)	)	-RRB-
cord-022313-2675sjlf	132	36	.	.	.
cord-022313-2675sjlf	133	1	Although	although	IN
cord-022313-2675sjlf	133	2	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	133	3	II	II	NNP
cord-022313-2675sjlf	133	4	also	also	RB
cord-022313-2675sjlf	133	5	can	can	MD
cord-022313-2675sjlf	133	6	catalyze	catalyze	VB
cord-022313-2675sjlf	133	7	the	the	DT
cord-022313-2675sjlf	133	8	cleavage	cleavage	NN
cord-022313-2675sjlf	133	9	of	of	IN
cord-022313-2675sjlf	133	10	aryl	aryl	NN
cord-022313-2675sjlf	133	11	-	-	HYPH
cord-022313-2675sjlf	133	12	a	a	DT
cord-022313-2675sjlf	133	13	-	-	HYPH
cord-022313-2675sjlf	133	14	glucosides	glucoside	NNS
cord-022313-2675sjlf	133	15	such	such	JJ
cord-022313-2675sjlf	133	16	as	as	IN
cord-022313-2675sjlf	133	17	p	p	NN
cord-022313-2675sjlf	133	18	-	-	HYPH
cord-022313-2675sjlf	133	19	nitrophenyl	nitrophenyl	NN
cord-022313-2675sjlf	133	20	-	-	HYPH
cord-022313-2675sjlf	133	21	a	a	DT
cord-022313-2675sjlf	133	22	-	-	HYPH
cord-022313-2675sjlf	133	23	glucopyranoside	glucopyranoside	NN
cord-022313-2675sjlf	133	24	,	,	,
cord-022313-2675sjlf	133	25	it	-PRON-	PRP
cord-022313-2675sjlf	133	26	appears	appear	VBZ
cord-022313-2675sjlf	133	27	to	to	TO
cord-022313-2675sjlf	133	28	be	be	VB
cord-022313-2675sjlf	133	29	fairly	fairly	RB
cord-022313-2675sjlf	133	30	specific	specific	JJ
cord-022313-2675sjlf	133	31	for	for	IN
cord-022313-2675sjlf	133	32	al,3-linked	al,3-linked	JJ
cord-022313-2675sjlf	133	33	glucoses	glucose	NNS
cord-022313-2675sjlf	133	34	since	since	IN
cord-022313-2675sjlf	133	35	its	-PRON-	PRP$
cord-022313-2675sjlf	133	36	activity	activity	NN
cord-022313-2675sjlf	133	37	is	be	VBZ
cord-022313-2675sjlf	133	38	inhibited	inhibit	VBN
cord-022313-2675sjlf	133	39	by	by	IN
cord-022313-2675sjlf	133	40	the	the	DT
cord-022313-2675sjlf	133	41	al,3-linked	al,3-linked	JJ
cord-022313-2675sjlf	133	42	glucose	glucose	NN
cord-022313-2675sjlf	133	43	disaccharide	disaccharide	NN
cord-022313-2675sjlf	133	44	nigerose	nigerose	NN
cord-022313-2675sjlf	133	45	,	,	,
cord-022313-2675sjlf	133	46	but	but	CC
cord-022313-2675sjlf	133	47	not	not	RB
cord-022313-2675sjlf	133	48	by	by	IN
cord-022313-2675sjlf	133	49	other	other	JJ
cord-022313-2675sjlf	133	50	α	α	NN
cord-022313-2675sjlf	133	51	-	-	HYPH
cord-022313-2675sjlf	133	52	linked	link	VBN
cord-022313-2675sjlf	133	53	glucose	glucose	NN
cord-022313-2675sjlf	133	54	disaccharides	disaccharide	NNS
cord-022313-2675sjlf	133	55	(	(	-LRB-
cord-022313-2675sjlf	133	56	i.e.	i.e.	FW
cord-022313-2675sjlf	133	57	,	,	,
cord-022313-2675sjlf	133	58	kojibiose	kojibiose	NNP
cord-022313-2675sjlf	133	59	,	,	,
cord-022313-2675sjlf	133	60	maltose	maltose	NN
cord-022313-2675sjlf	133	61	,	,	,
cord-022313-2675sjlf	133	62	isomaltose	isomaltose	NNP
cord-022313-2675sjlf	133	63	,	,	,
cord-022313-2675sjlf	133	64	or	or	CC
cord-022313-2675sjlf	133	65	trehalose	trehalose	DT
cord-022313-2675sjlf	133	66	)	)	-RRB-
cord-022313-2675sjlf	133	67	(	(	-LRB-
cord-022313-2675sjlf	133	68	64	64	CD
cord-022313-2675sjlf	133	69	)	)	-RRB-
cord-022313-2675sjlf	133	70	.	.	.
cord-022313-2675sjlf	134	1	Glucosidase	Glucosidase	NNP
cord-022313-2675sjlf	134	2	II	II	NNP
cord-022313-2675sjlf	134	3	from	from	IN
cord-022313-2675sjlf	134	4	pig	pig	NN
cord-022313-2675sjlf	134	5	kidney	kidney	NN
cord-022313-2675sjlf	134	6	was	be	VBD
cord-022313-2675sjlf	134	7	re	re	VBN
cord-022313-2675sjlf	134	8	ported	port	VBN
cord-022313-2675sjlf	134	9	to	to	TO
cord-022313-2675sjlf	134	10	have	have	VB
cord-022313-2675sjlf	134	11	a	a	DT
cord-022313-2675sjlf	134	12	subunit	subunit	NN
cord-022313-2675sjlf	134	13	molecular	molecular	JJ
cord-022313-2675sjlf	134	14	mass	mass	NN
cord-022313-2675sjlf	134	15	of	of	IN
cord-022313-2675sjlf	134	16	100	100	CD
cord-022313-2675sjlf	134	17	kDa	kDa	NNS
cord-022313-2675sjlf	134	18	and	and	CC
cord-022313-2675sjlf	134	19	to	to	TO
cord-022313-2675sjlf	134	20	be	be	VB
cord-022313-2675sjlf	134	21	a	a	DT
cord-022313-2675sjlf	134	22	highmannose	highmannose	JJ
cord-022313-2675sjlf	134	23	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	134	24	(	(	-LRB-
cord-022313-2675sjlf	134	25	65	65	CD
cord-022313-2675sjlf	134	26	)	)	-RRB-
cord-022313-2675sjlf	134	27	,	,	,
cord-022313-2675sjlf	134	28	whereas	whereas	IN
cord-022313-2675sjlf	134	29	the	the	DT
cord-022313-2675sjlf	134	30	enzyme	enzyme	NN
cord-022313-2675sjlf	134	31	from	from	IN
cord-022313-2675sjlf	134	32	mung	mung	NN
cord-022313-2675sjlf	134	33	beans	bean	NNS
cord-022313-2675sjlf	134	34	was	be	VBD
cord-022313-2675sjlf	134	35	composed	compose	VBN
cord-022313-2675sjlf	134	36	of	of	IN
cord-022313-2675sjlf	134	37	two	two	CD
cord-022313-2675sjlf	134	38	identical	identical	JJ
cord-022313-2675sjlf	134	39	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	134	40	subunits	subunit	NNS
cord-022313-2675sjlf	134	41	of	of	IN
cord-022313-2675sjlf	134	42	110	110	CD
cord-022313-2675sjlf	134	43	kDa	kDa	NNS
cord-022313-2675sjlf	134	44	,	,	,
cord-022313-2675sjlf	134	45	also	also	RB
cord-022313-2675sjlf	134	46	with	with	IN
cord-022313-2675sjlf	134	47	high	high	JJ
cord-022313-2675sjlf	134	48	mannose	mannose	NN
cord-022313-2675sjlf	134	49	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	134	50	(	(	-LRB-
cord-022313-2675sjlf	134	51	some	some	DT
cord-022313-2675sjlf	134	52	of	of	IN
cord-022313-2675sjlf	134	53	which	which	WDT
cord-022313-2675sjlf	134	54	probably	probably	RB
cord-022313-2675sjlf	134	55	also	also	RB
cord-022313-2675sjlf	134	56	contain	contain	VBP
cord-022313-2675sjlf	134	57	some	some	DT
cord-022313-2675sjlf	134	58	glucose	glucose	NN
cord-022313-2675sjlf	134	59	residues	residue	NNS
cord-022313-2675sjlf	134	60	)	)	-RRB-
cord-022313-2675sjlf	134	61	(	(	-LRB-
cord-022313-2675sjlf	134	62	64	64	CD
cord-022313-2675sjlf	134	63	)	)	-RRB-
cord-022313-2675sjlf	134	64	.	.	.
cord-022313-2675sjlf	135	1	In	in	IN
cord-022313-2675sjlf	135	2	some	some	DT
cord-022313-2675sjlf	135	3	animal	animal	NN
cord-022313-2675sjlf	135	4	systems	system	NNS
cord-022313-2675sjlf	135	5	,	,	,
cord-022313-2675sjlf	135	6	however	however	RB
cord-022313-2675sjlf	135	7	,	,	,
cord-022313-2675sjlf	135	8	the	the	DT
cord-022313-2675sjlf	135	9	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	135	10	II	II	NNP
cord-022313-2675sjlf	135	11	had	have	VBD
cord-022313-2675sjlf	135	12	quite	quite	RB
cord-022313-2675sjlf	135	13	different	different	JJ
cord-022313-2675sjlf	135	14	subunit	subunit	NN
cord-022313-2675sjlf	135	15	molecular	molecular	JJ
cord-022313-2675sjlf	135	16	weights	weight	NNS
cord-022313-2675sjlf	135	17	of	of	IN
cord-022313-2675sjlf	135	18	around	around	IN
cord-022313-2675sjlf	135	19	65	65	CD
cord-022313-2675sjlf	135	20	kDa	kDa	NNS
cord-022313-2675sjlf	135	21	(	(	-LRB-
cord-022313-2675sjlf	135	22	56	56	CD
cord-022313-2675sjlf	135	23	,	,	,
cord-022313-2675sjlf	135	24	66	66	CD
cord-022313-2675sjlf	135	25	)	)	-RRB-
cord-022313-2675sjlf	135	26	.	.	.
cord-022313-2675sjlf	136	1	The	the	DT
cord-022313-2675sjlf	136	2	localization	localization	NN
cord-022313-2675sjlf	136	3	of	of	IN
cord-022313-2675sjlf	136	4	the	the	DT
cord-022313-2675sjlf	136	5	enzyme	enzyme	NN
cord-022313-2675sjlf	136	6	has	have	VBZ
cord-022313-2675sjlf	136	7	also	also	RB
cord-022313-2675sjlf	136	8	been	be	VBN
cord-022313-2675sjlf	136	9	studied	study	VBN
cord-022313-2675sjlf	136	10	and	and	CC
cord-022313-2675sjlf	136	11	may	may	MD
cord-022313-2675sjlf	136	12	vary	vary	VB
cord-022313-2675sjlf	136	13	,	,	,
cord-022313-2675sjlf	136	14	depending	depend	VBG
cord-022313-2675sjlf	136	15	on	on	IN
cord-022313-2675sjlf	136	16	the	the	DT
cord-022313-2675sjlf	136	17	tissue	tissue	NN
cord-022313-2675sjlf	136	18	,	,	,
cord-022313-2675sjlf	136	19	from	from	IN
cord-022313-2675sjlf	136	20	being	be	VBG
cord-022313-2675sjlf	136	21	concentrated	concentrate	VBN
cord-022313-2675sjlf	136	22	in	in	IN
cord-022313-2675sjlf	136	23	rough	rough	JJ
cord-022313-2675sjlf	136	24	ER	er	NN
cord-022313-2675sjlf	136	25	(	(	-LRB-
cord-022313-2675sjlf	136	26	RER	RER	NNP
cord-022313-2675sjlf	136	27	)	)	-RRB-
cord-022313-2675sjlf	136	28	and	and	CC
cord-022313-2675sjlf	136	29	smooth	smooth	JJ
cord-022313-2675sjlf	136	30	ER	ER	NNP
cord-022313-2675sjlf	136	31	(	(	-LRB-
cord-022313-2675sjlf	136	32	SER	SER	NNP
cord-022313-2675sjlf	136	33	)	)	-RRB-
cord-022313-2675sjlf	136	34	in	in	IN
cord-022313-2675sjlf	136	35	pig	pig	NN
cord-022313-2675sjlf	136	36	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	136	37	(	(	-LRB-
cord-022313-2675sjlf	136	38	67	67	CD
cord-022313-2675sjlf	136	39	)	)	-RRB-
cord-022313-2675sjlf	136	40	to	to	TO
cord-022313-2675sjlf	136	41	post	post	VB
cord-022313-2675sjlf	136	42	-	-	JJ
cord-022313-2675sjlf	136	43	Golgi	golgi	JJ
cord-022313-2675sjlf	136	44	apparatus	apparatus	NN
cord-022313-2675sjlf	136	45	structures	structure	NNS
cord-022313-2675sjlf	136	46	in	in	IN
cord-022313-2675sjlf	136	47	pig	pig	NN
cord-022313-2675sjlf	136	48	kidney	kidney	NN
cord-022313-2675sjlf	136	49	tubular	tubular	JJ
cord-022313-2675sjlf	136	50	cells	cell	NNS
cord-022313-2675sjlf	136	51	(	(	-LRB-
cord-022313-2675sjlf	136	52	65	65	CD
cord-022313-2675sjlf	136	53	)	)	-RRB-
cord-022313-2675sjlf	136	54	.	.	.
cord-022313-2675sjlf	137	1	The	the	DT
cord-022313-2675sjlf	137	2	best	good	JJS
cord-022313-2675sjlf	137	3	substrates	substrate	NNS
cord-022313-2675sjlf	137	4	for	for	IN
cord-022313-2675sjlf	137	5	assaying	assay	VBG
cord-022313-2675sjlf	137	6	these	these	DT
cord-022313-2675sjlf	137	7	processing	processing	NN
cord-022313-2675sjlf	137	8	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	137	9	are	be	VBP
cord-022313-2675sjlf	137	10	radiolabeled	radiolabele	VBN
cord-022313-2675sjlf	137	11	Glc	Glc	NNP
cord-022313-2675sjlf	137	12	3	3	CD
cord-022313-2675sjlf	137	13	Man	Man	NNP
cord-022313-2675sjlf	137	14	9	9	CD
cord-022313-2675sjlf	137	15	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	137	16	and	and	CC
cord-022313-2675sjlf	137	17	Glc	Glc	NNP
cord-022313-2675sjlf	137	18	2	2	CD
cord-022313-2675sjlf	137	19	Man	Man	NNP
cord-022313-2675sjlf	137	20	9	9	CD
cord-022313-2675sjlf	137	21	GlcNAc	glcnac	NN
cord-022313-2675sjlf	137	22	.	.	.
cord-022313-2675sjlf	138	1	These	these	DT
cord-022313-2675sjlf	138	2	substrates	substrate	NNS
cord-022313-2675sjlf	138	3	can	can	MD
cord-022313-2675sjlf	138	4	be	be	VB
cord-022313-2675sjlf	138	5	prepared	prepare	VBN
cord-022313-2675sjlf	138	6	by	by	IN
cord-022313-2675sjlf	138	7	incubating	incubate	VBG
cord-022313-2675sjlf	138	8	animal	animal	NN
cord-022313-2675sjlf	138	9	cells	cell	NNS
cord-022313-2675sjlf	138	10	(	(	-LRB-
cord-022313-2675sjlf	138	11	or	or	CC
cord-022313-2675sjlf	138	12	virus	virus	NN
cord-022313-2675sjlf	138	13	-	-	HYPH
cord-022313-2675sjlf	138	14	infected	infect	VBN
cord-022313-2675sjlf	138	15	cells	cell	NNS
cord-022313-2675sjlf	138	16	)	)	-RRB-
cord-022313-2675sjlf	138	17	in	in	IN
cord-022313-2675sjlf	138	18	the	the	DT
cord-022313-2675sjlf	138	19	presence	presence	NN
cord-022313-2675sjlf	138	20	of	of	IN
cord-022313-2675sjlf	138	21	the	the	DT
cord-022313-2675sjlf	138	22	processing	processing	NN
cord-022313-2675sjlf	138	23	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	138	24	castanospermine	castanospermine	NNP
cord-022313-2675sjlf	138	25	(	(	-LRB-
cord-022313-2675sjlf	138	26	discussed	discuss	VBN
cord-022313-2675sjlf	138	27	later	later	RB
cord-022313-2675sjlf	138	28	)	)	-RRB-
cord-022313-2675sjlf	138	29	,	,	,
cord-022313-2675sjlf	138	30	to	to	TO
cord-022313-2675sjlf	138	31	prevent	prevent	VB
cord-022313-2675sjlf	138	32	the	the	DT
cord-022313-2675sjlf	138	33	removal	removal	NN
cord-022313-2675sjlf	138	34	of	of	IN
cord-022313-2675sjlf	138	35	glucose	glucose	NN
cord-022313-2675sjlf	138	36	residues	residue	NNS
cord-022313-2675sjlf	138	37	,	,	,
cord-022313-2675sjlf	138	38	and	and	CC
cord-022313-2675sjlf	138	39	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	138	40	,	,	,
cord-022313-2675sjlf	138	41	to	to	TO
cord-022313-2675sjlf	138	42	prevent	prevent	VB
cord-022313-2675sjlf	138	43	the	the	DT
cord-022313-2675sjlf	138	44	removal	removal	NN
cord-022313-2675sjlf	138	45	of	of	IN
cord-022313-2675sjlf	138	46	al,2-linked	al,2-linked	JJ
cord-022313-2675sjlf	138	47	mannoses	mannose	NNS
cord-022313-2675sjlf	138	48	.	.	.
cord-022313-2675sjlf	139	1	[	[	-LRB-
cord-022313-2675sjlf	139	2	3	3	CD
cord-022313-2675sjlf	139	3	H]Galactose	H]Galactose	NNP
cord-022313-2675sjlf	139	4	is	be	VBZ
cord-022313-2675sjlf	139	5	then	then	RB
cord-022313-2675sjlf	139	6	added	add	VBN
cord-022313-2675sjlf	139	7	to	to	IN
cord-022313-2675sjlf	139	8	the	the	DT
cord-022313-2675sjlf	139	9	cell	cell	NN
cord-022313-2675sjlf	139	10	cultures	culture	NNS
cord-022313-2675sjlf	139	11	to	to	TO
cord-022313-2675sjlf	139	12	label	label	VB
cord-022313-2675sjlf	139	13	the	the	DT
cord-022313-2675sjlf	139	14	glucose	glucose	NN
cord-022313-2675sjlf	139	15	moieties	moiety	NNS
cord-022313-2675sjlf	139	16	in	in	IN
cord-022313-2675sjlf	139	17	the	the	DT
cord-022313-2675sjlf	139	18	newly	newly	RB
cord-022313-2675sjlf	139	19	synthesized	synthesize	VBN
cord-022313-2675sjlf	139	20	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	139	21	.	.	.
cord-022313-2675sjlf	140	1	The	the	DT
cord-022313-2675sjlf	140	2	glycopeptides	glycopeptide	NNS
cord-022313-2675sjlf	140	3	resulting	result	VBG
cord-022313-2675sjlf	140	4	from	from	IN
cord-022313-2675sjlf	140	5	pronase	pronase	JJ
cord-022313-2675sjlf	140	6	digestion	digestion	NN
cord-022313-2675sjlf	140	7	of	of	IN
cord-022313-2675sjlf	140	8	the	the	DT
cord-022313-2675sjlf	140	9	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	140	10	are	be	VBP
cord-022313-2675sjlf	140	11	isolated	isolate	VBN
cord-022313-2675sjlf	140	12	by	by	IN
cord-022313-2675sjlf	140	13	gel	gel	NN
cord-022313-2675sjlf	140	14	filtration	filtration	NN
cord-022313-2675sjlf	140	15	on	on	IN
cord-022313-2675sjlf	140	16	columns	column	NNS
cord-022313-2675sjlf	140	17	of	of	IN
cord-022313-2675sjlf	140	18	Bio	Bio	NNP
cord-022313-2675sjlf	140	19	-	-	HYPH
cord-022313-2675sjlf	140	20	Gel	Gel	NNP
cord-022313-2675sjlf	140	21	P-4	P-4	NNP
cord-022313-2675sjlf	140	22	,	,	,
cord-022313-2675sjlf	140	23	and	and	CC
cord-022313-2675sjlf	140	24	these	these	DT
cord-022313-2675sjlf	140	25	glycopeptides	glycopeptide	NNS
cord-022313-2675sjlf	140	26	are	be	VBP
cord-022313-2675sjlf	140	27	then	then	RB
cord-022313-2675sjlf	140	28	treated	treat	VBN
cord-022313-2675sjlf	140	29	with	with	IN
cord-022313-2675sjlf	140	30	Endo	Endo	NNP
cord-022313-2675sjlf	140	31	H	H	NNP
cord-022313-2675sjlf	140	32	to	to	TO
cord-022313-2675sjlf	140	33	obtain	obtain	VB
cord-022313-2675sjlf	140	34	the	the	DT
cord-022313-2675sjlf	140	35	[	[	-LRB-
cord-022313-2675sjlf	140	36	3	3	CD
cord-022313-2675sjlf	140	37	H]glucose	H]glucose	NNP
cord-022313-2675sjlf	140	38	labeled	label	VBN
cord-022313-2675sjlf	141	1	Glc	Glc	NNP
cord-022313-2675sjlf	141	2	3	3	CD
cord-022313-2675sjlf	141	3	Man	Man	NNP
cord-022313-2675sjlf	141	4	9	9	CD
cord-022313-2675sjlf	141	5	GlcNAc	glcnac	NN
cord-022313-2675sjlf	141	6	.	.	.
cord-022313-2675sjlf	142	1	This	this	DT
cord-022313-2675sjlf	142	2	oligo	oligo	NN
cord-022313-2675sjlf	142	3	saccharide	saccharide	NN
cord-022313-2675sjlf	142	4	can	can	MD
cord-022313-2675sjlf	142	5	then	then	RB
cord-022313-2675sjlf	142	6	be	be	VB
cord-022313-2675sjlf	142	7	treated	treat	VBN
cord-022313-2675sjlf	142	8	with	with	IN
cord-022313-2675sjlf	142	9	a	a	DT
cord-022313-2675sjlf	142	10	glucosidase	glucosidase	NN
cord-022313-2675sjlf	143	1	I	-PRON-	PRP
cord-022313-2675sjlf	143	2	preparation	preparation	NN
cord-022313-2675sjlf	143	3	that	that	WDT
cord-022313-2675sjlf	143	4	is	be	VBZ
cord-022313-2675sjlf	143	5	free	free	JJ
cord-022313-2675sjlf	143	6	of	of	IN
cord-022313-2675sjlf	143	7	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	143	8	II	II	NNP
cord-022313-2675sjlf	143	9	and	and	CC
cord-022313-2675sjlf	143	10	α	α	NN
cord-022313-2675sjlf	143	11	-	-	HYPH
cord-022313-2675sjlf	143	12	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	143	13	to	to	TO
cord-022313-2675sjlf	143	14	obtain	obtain	VB
cord-022313-2675sjlf	143	15	[	[	-LRB-
cord-022313-2675sjlf	143	16	3	3	CD
cord-022313-2675sjlf	143	17	H]Glc	h]glc	NN
cord-022313-2675sjlf	143	18	2	2	CD
cord-022313-2675sjlf	143	19	Man	Man	NNP
cord-022313-2675sjlf	143	20	9	9	CD
cord-022313-2675sjlf	143	21	Glc	Glc	NNP
cord-022313-2675sjlf	143	22	NAc	NAc	NNP
cord-022313-2675sjlf	143	23	.	.	.
cord-022313-2675sjlf	144	1	For	for	IN
cord-022313-2675sjlf	144	2	assay	assay	NN
cord-022313-2675sjlf	144	3	of	of	IN
cord-022313-2675sjlf	144	4	the	the	DT
cord-022313-2675sjlf	144	5	processing	processing	NN
cord-022313-2675sjlf	144	6	glucosidase	glucosidase	NN
cord-022313-2675sjlf	144	7	activities	activity	NNS
cord-022313-2675sjlf	144	8	,	,	,
cord-022313-2675sjlf	144	9	the	the	DT
cord-022313-2675sjlf	144	10	previously	previously	RB
cord-022313-2675sjlf	144	11	mentioned	mention	VBN
cord-022313-2675sjlf	144	12	radiolabeled	radiolabele	VBN
cord-022313-2675sjlf	144	13	substrates	substrate	NNS
cord-022313-2675sjlf	144	14	are	be	VBP
cord-022313-2675sjlf	144	15	incubated	incubate	VBN
cord-022313-2675sjlf	144	16	with	with	IN
cord-022313-2675sjlf	144	17	the	the	DT
cord-022313-2675sjlf	144	18	appropriate	appropriate	JJ
cord-022313-2675sjlf	144	19	enzyme	enzyme	NN
cord-022313-2675sjlf	144	20	preparations	preparation	NNS
cord-022313-2675sjlf	144	21	,	,	,
cord-022313-2675sjlf	144	22	and	and	CC
cord-022313-2675sjlf	144	23	the	the	DT
cord-022313-2675sjlf	144	24	release	release	NN
cord-022313-2675sjlf	144	25	of	of	IN
cord-022313-2675sjlf	144	26	labeled	label	VBN
cord-022313-2675sjlf	144	27	glucose	glucose	NN
cord-022313-2675sjlf	144	28	is	be	VBZ
cord-022313-2675sjlf	144	29	measured	measure	VBN
cord-022313-2675sjlf	144	30	by	by	IN
cord-022313-2675sjlf	144	31	a	a	DT
cord-022313-2675sjlf	144	32	Concanavalin	Concanavalin	NNP
cord-022313-2675sjlf	144	33	A	A	NNP
cord-022313-2675sjlf	144	34	-	-	HYPH
cord-022313-2675sjlf	144	35	Sepharose	Sepharose	NNP
cord-022313-2675sjlf	144	36	binding	binding	NN
cord-022313-2675sjlf	144	37	assay	assay	NN
cord-022313-2675sjlf	144	38	(	(	-LRB-
cord-022313-2675sjlf	144	39	68	68	CD
cord-022313-2675sjlf	144	40	)	)	-RRB-
cord-022313-2675sjlf	144	41	.	.	.
cord-022313-2675sjlf	145	1	The	the	DT
cord-022313-2675sjlf	145	2	removal	removal	NN
cord-022313-2675sjlf	145	3	of	of	IN
cord-022313-2675sjlf	145	4	three	three	CD
cord-022313-2675sjlf	145	5	glucose	glucose	NN
cord-022313-2675sjlf	145	6	residues	residue	NNS
cord-022313-2675sjlf	145	7	from	from	IN
cord-022313-2675sjlf	145	8	the	the	DT
cord-022313-2675sjlf	145	9	Glc	Glc	NNP
cord-022313-2675sjlf	145	10	3	3	CD
cord-022313-2675sjlf	145	11	Man	Man	NNP
cord-022313-2675sjlf	145	12	9	9	CD
cord-022313-2675sjlf	145	13	(	(	-LRB-
cord-022313-2675sjlf	145	14	Glc	Glc	NNP
cord-022313-2675sjlf	145	15	NAc	NAc	NNP
cord-022313-2675sjlf	145	16	)	)	-RRB-
cord-022313-2675sjlf	146	1	2	2	LS
cord-022313-2675sjlf	146	2	-protein	-protein	SYM
cord-022313-2675sjlf	146	3	results	result	NNS
cord-022313-2675sjlf	146	4	in	in	IN
cord-022313-2675sjlf	146	5	the	the	DT
cord-022313-2675sjlf	146	6	formation	formation	NN
cord-022313-2675sjlf	146	7	of	of	IN
cord-022313-2675sjlf	146	8	a	a	DT
cord-022313-2675sjlf	146	9	high	high	JJ
cord-022313-2675sjlf	146	10	-	-	HYPH
cord-022313-2675sjlf	146	11	mannose	mannose	NN
cord-022313-2675sjlf	146	12	Man	Man	NNP
cord-022313-2675sjlf	146	13	9	9	CD
cord-022313-2675sjlf	146	14	(	(	-LRB-
cord-022313-2675sjlf	146	15	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	146	16	)	)	-RRB-
cord-022313-2675sjlf	146	17	2	2	CD
cord-022313-2675sjlf	146	18	-protein	-protein	CC
cord-022313-2675sjlf	146	19	,	,	,
cord-022313-2675sjlf	146	20	which	which	WDT
cord-022313-2675sjlf	146	21	can	can	MD
cord-022313-2675sjlf	146	22	then	then	RB
cord-022313-2675sjlf	146	23	be	be	VB
cord-022313-2675sjlf	146	24	further	further	RB
cord-022313-2675sjlf	146	25	processed	process	VBN
cord-022313-2675sjlf	146	26	to	to	IN
cord-022313-2675sjlf	146	27	other	other	JJ
cord-022313-2675sjlf	146	28	highmannose	highmannose	NNS
cord-022313-2675sjlf	146	29	or	or	CC
cord-022313-2675sjlf	146	30	complex	complex	JJ
cord-022313-2675sjlf	146	31	types	type	NNS
cord-022313-2675sjlf	146	32	of	of	IN
cord-022313-2675sjlf	146	33	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	146	34	(	(	-LRB-
cord-022313-2675sjlf	146	35	as	as	IN
cord-022313-2675sjlf	146	36	seen	see	VBN
cord-022313-2675sjlf	146	37	in	in	IN
cord-022313-2675sjlf	146	38	Figs	fig	NNS
cord-022313-2675sjlf	146	39	.	.	.
cord-022313-2675sjlf	147	1	1	1	CD
cord-022313-2675sjlf	147	2	and	and	CC
cord-022313-2675sjlf	147	3	 	 	_SP
cord-022313-2675sjlf	147	4	3	3	CD
cord-022313-2675sjlf	147	5	)	)	-RRB-
cord-022313-2675sjlf	147	6	.	.	.
cord-022313-2675sjlf	148	1	Early	early	JJ
cord-022313-2675sjlf	148	2	studies	study	NNS
cord-022313-2675sjlf	148	3	on	on	IN
cord-022313-2675sjlf	148	4	the	the	DT
cord-022313-2675sjlf	148	5	processing	processing	NN
cord-022313-2675sjlf	148	6	pathway	pathway	NN
cord-022313-2675sjlf	148	7	indicated	indicate	VBD
cord-022313-2675sjlf	148	8	that	that	IN
cord-022313-2675sjlf	148	9	there	there	EX
cord-022313-2675sjlf	148	10	were	be	VBD
cord-022313-2675sjlf	148	11	two	two	CD
cord-022313-2675sjlf	148	12	or	or	CC
cord-022313-2675sjlf	148	13	three	three	CD
cord-022313-2675sjlf	148	14	"	"	``
cord-022313-2675sjlf	148	15	neutral	neutral	JJ
cord-022313-2675sjlf	148	16	"	"	''
cord-022313-2675sjlf	148	17	α	α	NN
cord-022313-2675sjlf	148	18	-	-	HYPH
cord-022313-2675sjlf	148	19	mannosidase	mannosidase	NN
cord-022313-2675sjlf	148	20	activities	activity	NNS
cord-022313-2675sjlf	148	21	involved	involve	VBN
cord-022313-2675sjlf	148	22	in	in	IN
cord-022313-2675sjlf	148	23	trimming	trim	VBG
cord-022313-2675sjlf	148	24	the	the	DT
cord-022313-2675sjlf	148	25	N	n	CD
cord-022313-2675sjlf	148	26	-	-	HYPH
cord-022313-2675sjlf	148	27	linked	link	VBN
cord-022313-2675sjlf	148	28	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	148	29	,	,	,
cord-022313-2675sjlf	148	30	and	and	CC
cord-022313-2675sjlf	148	31	these	these	DT
cord-022313-2675sjlf	148	32	activities	activity	NNS
cord-022313-2675sjlf	148	33	were	be	VBD
cord-022313-2675sjlf	148	34	distinct	distinct	JJ
cord-022313-2675sjlf	148	35	from	from	IN
cord-022313-2675sjlf	148	36	those	those	DT
cord-022313-2675sjlf	148	37	of	of	IN
cord-022313-2675sjlf	148	38	the	the	DT
cord-022313-2675sjlf	148	39	lysosomal	lysosomal	NN
cord-022313-2675sjlf	148	40	α	α	NN
cord-022313-2675sjlf	148	41	-	-	HYPH
cord-022313-2675sjlf	148	42	mannosidase	mannosidase	NN
cord-022313-2675sjlf	148	43	(	(	-LRB-
cord-022313-2675sjlf	148	44	69	69	CD
cord-022313-2675sjlf	148	45	)	)	-RRB-
cord-022313-2675sjlf	148	46	.	.	.
cord-022313-2675sjlf	149	1	As	as	IN
cord-022313-2675sjlf	149	2	a	a	DT
cord-022313-2675sjlf	149	3	result	result	NN
cord-022313-2675sjlf	149	4	of	of	IN
cord-022313-2675sjlf	149	5	increasing	increase	VBG
cord-022313-2675sjlf	149	6	interest	interest	NN
cord-022313-2675sjlf	149	7	in	in	IN
cord-022313-2675sjlf	149	8	this	this	DT
cord-022313-2675sjlf	149	9	area	area	NN
cord-022313-2675sjlf	149	10	of	of	IN
cord-022313-2675sjlf	149	11	research	research	NN
cord-022313-2675sjlf	149	12	,	,	,
cord-022313-2675sjlf	149	13	a	a	DT
cord-022313-2675sjlf	149	14	number	number	NN
cord-022313-2675sjlf	149	15	of	of	IN
cord-022313-2675sjlf	149	16	new	new	JJ
cord-022313-2675sjlf	149	17	α	α	NN
cord-022313-2675sjlf	149	18	-	-	HYPH
cord-022313-2675sjlf	149	19	mannosidase	mannosidase	NN
cord-022313-2675sjlf	149	20	activi	activi	NNP
cord-022313-2675sjlf	149	21	ties	tie	NNS
cord-022313-2675sjlf	149	22	have	have	VBP
cord-022313-2675sjlf	149	23	been	be	VBN
cord-022313-2675sjlf	149	24	described	describe	VBN
cord-022313-2675sjlf	149	25	and	and	CC
cord-022313-2675sjlf	149	26	current	current	JJ
cord-022313-2675sjlf	149	27	work	work	NN
cord-022313-2675sjlf	149	28	is	be	VBZ
cord-022313-2675sjlf	149	29	aimed	aim	VBN
cord-022313-2675sjlf	149	30	at	at	IN
cord-022313-2675sjlf	149	31	trying	try	VBG
cord-022313-2675sjlf	149	32	to	to	TO
cord-022313-2675sjlf	149	33	under	under	IN
cord-022313-2675sjlf	149	34	stand	stand	VB
cord-022313-2675sjlf	149	35	how	how	WRB
cord-022313-2675sjlf	149	36	these	these	DT
cord-022313-2675sjlf	149	37	various	various	JJ
cord-022313-2675sjlf	149	38	enzymes	enzyme	NNS
cord-022313-2675sjlf	149	39	function	function	VBP
cord-022313-2675sjlf	149	40	in	in	IN
cord-022313-2675sjlf	149	41	the	the	DT
cord-022313-2675sjlf	149	42	removal	removal	NN
cord-022313-2675sjlf	149	43	of	of	IN
cord-022313-2675sjlf	149	44	α	α	NN
cord-022313-2675sjlf	149	45	-	-	HYPH
cord-022313-2675sjlf	149	46	linked	link	VBN
cord-022313-2675sjlf	149	47	mannoses	mannose	NNS
cord-022313-2675sjlf	149	48	from	from	IN
cord-022313-2675sjlf	149	49	eucaryotic	eucaryotic	JJ
cord-022313-2675sjlf	149	50	cell	cell	NN
cord-022313-2675sjlf	149	51	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	149	52	.	.	.
cord-022313-2675sjlf	150	1	In	in	IN
cord-022313-2675sjlf	150	2	fact	fact	NN
cord-022313-2675sjlf	150	3	,	,	,
cord-022313-2675sjlf	150	4	one	one	CD
cord-022313-2675sjlf	150	5	of	of	IN
cord-022313-2675sjlf	150	6	the	the	DT
cord-022313-2675sjlf	150	7	i	-PRON-	PRP
cord-022313-2675sjlf	150	8	m	be	VBP
cord-022313-2675sjlf	150	9	portant	portant	JJ
cord-022313-2675sjlf	150	10	reasons	reason	NNS
cord-022313-2675sjlf	150	11	for	for	IN
cord-022313-2675sjlf	150	12	having	have	VBG
cord-022313-2675sjlf	150	13	a	a	DT
cord-022313-2675sjlf	150	14	number	number	NN
cord-022313-2675sjlf	150	15	of	of	IN
cord-022313-2675sjlf	150	16	specific	specific	JJ
cord-022313-2675sjlf	150	17	mannosidase	mannosidase	NN
cord-022313-2675sjlf	150	18	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	150	19	(	(	-LRB-
cord-022313-2675sjlf	150	20	see	see	VB
cord-022313-2675sjlf	150	21	Section	section	NN
cord-022313-2675sjlf	150	22	V	v	NN
cord-022313-2675sjlf	150	23	)	)	-RRB-
cord-022313-2675sjlf	150	24	is	be	VBZ
cord-022313-2675sjlf	150	25	to	to	TO
cord-022313-2675sjlf	150	26	be	be	VB
cord-022313-2675sjlf	150	27	able	able	JJ
cord-022313-2675sjlf	150	28	to	to	TO
cord-022313-2675sjlf	150	29	use	use	VB
cord-022313-2675sjlf	150	30	them	-PRON-	PRP
cord-022313-2675sjlf	150	31	to	to	TO
cord-022313-2675sjlf	150	32	distinguish	distinguish	VB
cord-022313-2675sjlf	150	33	among	among	IN
cord-022313-2675sjlf	150	34	various	various	JJ
cord-022313-2675sjlf	150	35	mannosidase	mannosidase	NN
cord-022313-2675sjlf	150	36	activities	activity	NNS
cord-022313-2675sjlf	150	37	,	,	,
cord-022313-2675sjlf	150	38	as	as	RB
cord-022313-2675sjlf	150	39	well	well	RB
cord-022313-2675sjlf	150	40	as	as	IN
cord-022313-2675sjlf	150	41	to	to	TO
cord-022313-2675sjlf	150	42	determine	determine	VB
cord-022313-2675sjlf	150	43	what	what	WP
cord-022313-2675sjlf	150	44	happens	happen	VBZ
cord-022313-2675sjlf	150	45	to	to	IN
cord-022313-2675sjlf	150	46	pro	pro	JJ
cord-022313-2675sjlf	150	47	cessing	cessing	NN
cord-022313-2675sjlf	150	48	and	and	CC
cord-022313-2675sjlf	150	49	function	function	NN
cord-022313-2675sjlf	150	50	of	of	IN
cord-022313-2675sjlf	150	51	a	a	DT
cord-022313-2675sjlf	150	52	given	give	VBN
cord-022313-2675sjlf	150	53	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	150	54	when	when	WRB
cord-022313-2675sjlf	150	55	a	a	DT
cord-022313-2675sjlf	150	56	specific	specific	JJ
cord-022313-2675sjlf	150	57	a	a	DT
cord-022313-2675sjlf	150	58	-	-	HYPH
cord-022313-2675sjlf	150	59	mannosidase	mannosidase	NN
cord-022313-2675sjlf	150	60	is	be	VBZ
cord-022313-2675sjlf	150	61	inhibited	inhibit	VBN
cord-022313-2675sjlf	150	62	.	.	.
cord-022313-2675sjlf	151	1	A	a	DT
cord-022313-2675sjlf	151	2	well	well	RB
cord-022313-2675sjlf	151	3	-	-	HYPH
cord-022313-2675sjlf	151	4	written	write	VBN
cord-022313-2675sjlf	151	5	review	review	NN
cord-022313-2675sjlf	151	6	deals	deal	NNS
cord-022313-2675sjlf	151	7	with	with	IN
cord-022313-2675sjlf	151	8	the	the	DT
cord-022313-2675sjlf	151	9	various	various	JJ
cord-022313-2675sjlf	151	10	amannosidases	amannosidase	NNS
cord-022313-2675sjlf	151	11	(	(	-LRB-
cord-022313-2675sjlf	151	12	70	70	CD
cord-022313-2675sjlf	151	13	)	)	-RRB-
cord-022313-2675sjlf	151	14	,	,	,
cord-022313-2675sjlf	151	15	so	so	IN
cord-022313-2675sjlf	151	16	these	these	DT
cord-022313-2675sjlf	151	17	enzymes	enzyme	NNS
cord-022313-2675sjlf	151	18	will	will	MD
cord-022313-2675sjlf	151	19	be	be	VB
cord-022313-2675sjlf	151	20	only	only	RB
cord-022313-2675sjlf	151	21	briefly	briefly	RB
cord-022313-2675sjlf	151	22	covered	cover	VBN
cord-022313-2675sjlf	151	23	here	here	RB
cord-022313-2675sjlf	151	24	.	.	.
cord-022313-2675sjlf	152	1	An	an	DT
cord-022313-2675sjlf	152	2	ER	ER	NNP
cord-022313-2675sjlf	152	3	α	α	NN
cord-022313-2675sjlf	152	4	-	-	HYPH
cord-022313-2675sjlf	152	5	mannosidase	mannosidase	NN
cord-022313-2675sjlf	152	6	that	that	WDT
cord-022313-2675sjlf	152	7	removes	remove	VBZ
cord-022313-2675sjlf	152	8	a	a	DT
cord-022313-2675sjlf	152	9	single	single	JJ
cord-022313-2675sjlf	152	10	al,2-linked	al,2-linked	JJ
cord-022313-2675sjlf	152	11	man	man	NN
cord-022313-2675sjlf	152	12	nose	nose	NN
cord-022313-2675sjlf	152	13	from	from	IN
cord-022313-2675sjlf	152	14	Man	Man	NNP
cord-022313-2675sjlf	152	15	9	9	CD
cord-022313-2675sjlf	152	16	(	(	-LRB-
cord-022313-2675sjlf	152	17	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	152	18	)	)	-RRB-
cord-022313-2675sjlf	152	19	2	2	CD
cord-022313-2675sjlf	152	20	to	to	TO
cord-022313-2675sjlf	152	21	give	give	VB
cord-022313-2675sjlf	152	22	a	a	DT
cord-022313-2675sjlf	152	23	specific	specific	JJ
cord-022313-2675sjlf	152	24	Man	man	NN
cord-022313-2675sjlf	152	25	8	8	CD
cord-022313-2675sjlf	152	26	(	(	-LRB-
cord-022313-2675sjlf	152	27	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	152	28	)	)	-RRB-
cord-022313-2675sjlf	152	29	2	2	CD
cord-022313-2675sjlf	152	30	isomer	isomer	NN
cord-022313-2675sjlf	152	31	has	have	VBZ
cord-022313-2675sjlf	152	32	been	be	VBN
cord-022313-2675sjlf	152	33	purified	purify	VBN
cord-022313-2675sjlf	152	34	from	from	IN
cord-022313-2675sjlf	152	35	yeast	yeast	NN
cord-022313-2675sjlf	152	36	(	(	-LRB-
cord-022313-2675sjlf	152	37	71	71	CD
cord-022313-2675sjlf	152	38	)	)	-RRB-
cord-022313-2675sjlf	152	39	.	.	.
cord-022313-2675sjlf	153	1	This	this	DT
cord-022313-2675sjlf	153	2	enzyme	enzyme	NN
cord-022313-2675sjlf	153	3	is	be	VBZ
cord-022313-2675sjlf	153	4	inhibited	inhibit	VBN
cord-022313-2675sjlf	153	5	by	by	IN
cord-022313-2675sjlf	153	6	the	the	DT
cord-022313-2675sjlf	153	7	pro	pro	JJ
cord-022313-2675sjlf	153	8	cessing	cessing	NN
cord-022313-2675sjlf	153	9	inhibitor	inhibitor	NN
cord-022313-2675sjlf	153	10	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	153	11	,	,	,
cord-022313-2675sjlf	153	12	requires	require	VBZ
cord-022313-2675sjlf	153	13	Ca	Ca	NNP
cord-022313-2675sjlf	153	14	2	2	CD
cord-022313-2675sjlf	153	15	+	+	SYM
cord-022313-2675sjlf	153	16	for	for	IN
cord-022313-2675sjlf	153	17	activity	activity	NN
cord-022313-2675sjlf	153	18	,	,	,
cord-022313-2675sjlf	153	19	and	and	CC
cord-022313-2675sjlf	153	20	does	do	VBZ
cord-022313-2675sjlf	153	21	not	not	RB
cord-022313-2675sjlf	153	22	work	work	VB
cord-022313-2675sjlf	153	23	with	with	IN
cord-022313-2675sjlf	153	24	aryl	aryl	RB
cord-022313-2675sjlf	153	25	-	-	HYPH
cord-022313-2675sjlf	153	26	a	a	DT
cord-022313-2675sjlf	153	27	-	-	HYPH
cord-022313-2675sjlf	153	28	mannosides	mannoside	NNS
cord-022313-2675sjlf	153	29	.	.	.
cord-022313-2675sjlf	154	1	The	the	DT
cord-022313-2675sjlf	154	2	gene	gene	NN
cord-022313-2675sjlf	154	3	for	for	IN
cord-022313-2675sjlf	154	4	the	the	DT
cord-022313-2675sjlf	154	5	enzyme	enzyme	NN
cord-022313-2675sjlf	154	6	has	have	VBZ
cord-022313-2675sjlf	154	7	been	be	VBN
cord-022313-2675sjlf	154	8	isolated	isolate	VBN
cord-022313-2675sjlf	154	9	and	and	CC
cord-022313-2675sjlf	154	10	codes	code	NNS
cord-022313-2675sjlf	154	11	for	for	IN
cord-022313-2675sjlf	154	12	a	a	DT
cord-022313-2675sjlf	154	13	63-kDa	63-kda	CD
cord-022313-2675sjlf	154	14	protein	protein	NN
cord-022313-2675sjlf	154	15	with	with	IN
cord-022313-2675sjlf	154	16	three	three	CD
cord-022313-2675sjlf	154	17	Nglycosylation	Nglycosylation	NNP
cord-022313-2675sjlf	154	18	sites	site	NNS
cord-022313-2675sjlf	154	19	,	,	,
cord-022313-2675sjlf	154	20	a	a	DT
cord-022313-2675sjlf	155	1	Ca	ca	NN
cord-022313-2675sjlf	155	2	2	2	CD
cord-022313-2675sjlf	155	3	+	+	SYM
cord-022313-2675sjlf	155	4	binding	bind	VBG
cord-022313-2675sjlf	155	5	consensus	consensus	NN
cord-022313-2675sjlf	155	6	sequence	sequence	NN
cord-022313-2675sjlf	155	7	,	,	,
cord-022313-2675sjlf	155	8	and	and	CC
cord-022313-2675sjlf	155	9	a	a	DT
cord-022313-2675sjlf	155	10	noncleavable	noncleavable	JJ
cord-022313-2675sjlf	155	11	signal	signal	NN
cord-022313-2675sjlf	155	12	sequence	sequence	NN
cord-022313-2675sjlf	155	13	near	near	IN
cord-022313-2675sjlf	155	14	the	the	DT
cord-022313-2675sjlf	155	15	Ν	ν	NN
cord-022313-2675sjlf	155	16	terminus	terminus	NN
cord-022313-2675sjlf	155	17	that	that	WDT
cord-022313-2675sjlf	155	18	acts	act	VBZ
cord-022313-2675sjlf	155	19	as	as	IN
cord-022313-2675sjlf	155	20	a	a	DT
cord-022313-2675sjlf	155	21	transmembrane	transmembrane	NN
cord-022313-2675sjlf	155	22	type	type	NN
cord-022313-2675sjlf	155	23	II	ii	CD
cord-022313-2675sjlf	155	24	domain	domain	NN
cord-022313-2675sjlf	155	25	(	(	-LRB-
cord-022313-2675sjlf	155	26	72	72	CD
cord-022313-2675sjlf	155	27	)	)	-RRB-
cord-022313-2675sjlf	155	28	.	.	.
cord-022313-2675sjlf	156	1	A	a	DT
cord-022313-2675sjlf	157	1	Ca	ca	NN
cord-022313-2675sjlf	157	2	2	2	CD
cord-022313-2675sjlf	157	3	+	+	SYM
cord-022313-2675sjlf	157	4	requiring	require	VBG
cord-022313-2675sjlf	157	5	al,2-mannosidase	al,2-mannosidase	NN
cord-022313-2675sjlf	157	6	was	be	VBD
cord-022313-2675sjlf	157	7	also	also	RB
cord-022313-2675sjlf	157	8	puri	puri	NNP
cord-022313-2675sjlf	157	9	fied	fie	VBN
cord-022313-2675sjlf	157	10	from	from	IN
cord-022313-2675sjlf	157	11	rabbit	rabbit	NN
cord-022313-2675sjlf	157	12	liver	liver	NN
cord-022313-2675sjlf	157	13	and	and	CC
cord-022313-2675sjlf	157	14	this	this	DT
cord-022313-2675sjlf	157	15	enzyme	enzyme	NN
cord-022313-2675sjlf	157	16	shows	show	VBZ
cord-022313-2675sjlf	157	17	considerable	considerable	JJ
cord-022313-2675sjlf	157	18	homology	homology	NN
cord-022313-2675sjlf	157	19	(	(	-LRB-
cord-022313-2675sjlf	157	20	38	38	CD
cord-022313-2675sjlf	157	21	%	%	NN
cord-022313-2675sjlf	157	22	identity	identity	NN
cord-022313-2675sjlf	157	23	and	and	CC
cord-022313-2675sjlf	157	24	58	58	CD
cord-022313-2675sjlf	157	25	%	%	NN
cord-022313-2675sjlf	157	26	similarity	similarity	NN
cord-022313-2675sjlf	157	27	)	)	-RRB-
cord-022313-2675sjlf	157	28	to	to	IN
cord-022313-2675sjlf	157	29	the	the	DT
cord-022313-2675sjlf	157	30	yeast	yeast	NN
cord-022313-2675sjlf	157	31	enzyme	enzyme	NN
cord-022313-2675sjlf	157	32	(	(	-LRB-
cord-022313-2675sjlf	157	33	73	73	CD
cord-022313-2675sjlf	157	34	)	)	-RRB-
cord-022313-2675sjlf	157	35	.	.	.
cord-022313-2675sjlf	158	1	However	however	RB
cord-022313-2675sjlf	158	2	,	,	,
cord-022313-2675sjlf	158	3	the	the	DT
cord-022313-2675sjlf	158	4	rabbit	rabbit	NN
cord-022313-2675sjlf	158	5	liver	liver	NN
cord-022313-2675sjlf	158	6	enzyme	enzyme	NN
cord-022313-2675sjlf	158	7	can	can	MD
cord-022313-2675sjlf	158	8	remove	remove	VB
cord-022313-2675sjlf	158	9	most	most	JJS
cord-022313-2675sjlf	158	10	if	if	IN
cord-022313-2675sjlf	158	11	not	not	RB
cord-022313-2675sjlf	158	12	all	all	DT
cord-022313-2675sjlf	158	13	of	of	IN
cord-022313-2675sjlf	158	14	the	the	DT
cord-022313-2675sjlf	158	15	al,2-linked	al,2-linked	JJ
cord-022313-2675sjlf	158	16	mannoses	mannose	NNS
cord-022313-2675sjlf	158	17	from	from	IN
cord-022313-2675sjlf	158	18	Man	Man	NNP
cord-022313-2675sjlf	158	19	9	9	CD
cord-022313-2675sjlf	158	20	(	(	-LRB-
cord-022313-2675sjlf	158	21	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	158	22	)	)	-RRB-
cord-022313-2675sjlf	158	23	2	2	CD
cord-022313-2675sjlf	158	24	,	,	,
cord-022313-2675sjlf	158	25	and	and	CC
cord-022313-2675sjlf	158	26	it	-PRON-	PRP
cord-022313-2675sjlf	158	27	requires	require	VBZ
cord-022313-2675sjlf	158	28	either	either	CC
cord-022313-2675sjlf	158	29	nonionic	nonionic	JJ
cord-022313-2675sjlf	158	30	deter	deter	VB
cord-022313-2675sjlf	158	31	gents	gent	NNS
cord-022313-2675sjlf	158	32	or	or	CC
cord-022313-2675sjlf	158	33	phospholipids	phospholipid	NNS
cord-022313-2675sjlf	158	34	for	for	IN
cord-022313-2675sjlf	158	35	activity	activity	NN
cord-022313-2675sjlf	158	36	(	(	-LRB-
cord-022313-2675sjlf	158	37	74	74	CD
cord-022313-2675sjlf	158	38	)	)	-RRB-
cord-022313-2675sjlf	158	39	.	.	.
cord-022313-2675sjlf	159	1	Two	two	CD
cord-022313-2675sjlf	159	2	other	other	JJ
cord-022313-2675sjlf	160	1	Ca	ca	NN
cord-022313-2675sjlf	160	2	2	2	CD
cord-022313-2675sjlf	160	3	+	+	SYM
cord-022313-2675sjlf	160	4	requiring	require	VBG
cord-022313-2675sjlf	160	5	amannosidases	amannosidase	NNS
cord-022313-2675sjlf	160	6	have	have	VBP
cord-022313-2675sjlf	160	7	been	be	VBN
cord-022313-2675sjlf	160	8	purified	purify	VBN
cord-022313-2675sjlf	160	9	from	from	IN
cord-022313-2675sjlf	160	10	calf	calf	NN
cord-022313-2675sjlf	160	11	(	(	-LRB-
cord-022313-2675sjlf	160	12	75	75	CD
cord-022313-2675sjlf	160	13	)	)	-RRB-
cord-022313-2675sjlf	160	14	and	and	CC
cord-022313-2675sjlf	160	15	pig	pig	NN
cord-022313-2675sjlf	160	16	(	(	-LRB-
cord-022313-2675sjlf	160	17	76	76	CD
cord-022313-2675sjlf	160	18	)	)	-RRB-
cord-022313-2675sjlf	160	19	livers	liver	NNS
cord-022313-2675sjlf	160	20	,	,	,
cord-022313-2675sjlf	160	21	and	and	CC
cord-022313-2675sjlf	160	22	these	these	DT
cord-022313-2675sjlf	160	23	enzymes	enzyme	NNS
cord-022313-2675sjlf	160	24	differ	differ	VBP
cord-022313-2675sjlf	160	25	from	from	IN
cord-022313-2675sjlf	160	26	the	the	DT
cord-022313-2675sjlf	160	27	rabbit	rabbit	NN
cord-022313-2675sjlf	160	28	enzyme	enzyme	NN
cord-022313-2675sjlf	160	29	in	in	IN
cord-022313-2675sjlf	160	30	some	some	DT
cord-022313-2675sjlf	160	31	of	of	IN
cord-022313-2675sjlf	160	32	their	-PRON-	PRP$
cord-022313-2675sjlf	160	33	properties	property	NNS
cord-022313-2675sjlf	160	34	.	.	.
cord-022313-2675sjlf	161	1	These	these	DT
cord-022313-2675sjlf	161	2	enzymes	enzyme	NNS
cord-022313-2675sjlf	161	3	also	also	RB
cord-022313-2675sjlf	161	4	do	do	VBP
cord-022313-2675sjlf	161	5	not	not	RB
cord-022313-2675sjlf	161	6	work	work	VB
cord-022313-2675sjlf	161	7	with	with	IN
cord-022313-2675sjlf	161	8	the	the	DT
cord-022313-2675sjlf	161	9	aryl	aryl	NN
cord-022313-2675sjlf	161	10	-	-	HYPH
cord-022313-2675sjlf	161	11	a	a	NN
cord-022313-2675sjlf	161	12	-	-	HYPH
cord-022313-2675sjlf	161	13	mannopyranosides	mannopyranoside	NNS
cord-022313-2675sjlf	161	14	as	as	IN
cord-022313-2675sjlf	161	15	substrates	substrate	NNS
cord-022313-2675sjlf	161	16	.	.	.
cord-022313-2675sjlf	162	1	The	the	DT
cord-022313-2675sjlf	162	2	pig	pig	NN
cord-022313-2675sjlf	162	3	liver	liver	NN
cord-022313-2675sjlf	162	4	enzyme	enzyme	NN
cord-022313-2675sjlf	162	5	was	be	VBD
cord-022313-2675sjlf	162	6	localized	localize	VBN
cord-022313-2675sjlf	162	7	by	by	IN
cord-022313-2675sjlf	162	8	immunological	immunological	JJ
cord-022313-2675sjlf	162	9	techniques	technique	NNS
cord-022313-2675sjlf	162	10	and	and	CC
cord-022313-2675sjlf	162	11	found	find	VBD
cord-022313-2675sjlf	162	12	to	to	TO
cord-022313-2675sjlf	162	13	be	be	VB
cord-022313-2675sjlf	162	14	distributed	distribute	VBN
cord-022313-2675sjlf	162	15	in	in	IN
cord-022313-2675sjlf	162	16	RER	RER	NNP
cord-022313-2675sjlf	162	17	,	,	,
cord-022313-2675sjlf	162	18	SER	SER	NNP
cord-022313-2675sjlf	162	19	,	,	,
cord-022313-2675sjlf	162	20	transitional	transitional	JJ
cord-022313-2675sjlf	162	21	ele	ele	NN
cord-022313-2675sjlf	162	22	ments	ment	NNS
cord-022313-2675sjlf	162	23	of	of	IN
cord-022313-2675sjlf	162	24	the	the	DT
cord-022313-2675sjlf	162	25	RER	RER	NNP
cord-022313-2675sjlf	162	26	,	,	,
cord-022313-2675sjlf	162	27	and	and	CC
cord-022313-2675sjlf	162	28	vesicles	vesicle	NNS
cord-022313-2675sjlf	162	29	that	that	WDT
cord-022313-2675sjlf	162	30	engage	engage	VBP
cord-022313-2675sjlf	162	31	in	in	IN
cord-022313-2675sjlf	162	32	transportation	transportation	NN
cord-022313-2675sjlf	162	33	between	between	IN
cord-022313-2675sjlf	162	34	the	the	DT
cord-022313-2675sjlf	162	35	ER	ER	NNP
cord-022313-2675sjlf	162	36	and	and	CC
cord-022313-2675sjlf	162	37	the	the	DT
cord-022313-2675sjlf	162	38	Golgi	Golgi	NNP
cord-022313-2675sjlf	162	39	,	,	,
cord-022313-2675sjlf	162	40	but	but	CC
cord-022313-2675sjlf	162	41	it	-PRON-	PRP
cord-022313-2675sjlf	162	42	was	be	VBD
cord-022313-2675sjlf	162	43	not	not	RB
cord-022313-2675sjlf	162	44	in	in	IN
cord-022313-2675sjlf	162	45	the	the	DT
cord-022313-2675sjlf	162	46	Golgi	Golgi	NNP
cord-022313-2675sjlf	162	47	(	(	-LRB-
cord-022313-2675sjlf	162	48	77	77	CD
cord-022313-2675sjlf	162	49	)	)	-RRB-
cord-022313-2675sjlf	162	50	.	.	.
cord-022313-2675sjlf	163	1	Actually	actually	RB
cord-022313-2675sjlf	163	2	,	,	,
cord-022313-2675sjlf	163	3	the	the	DT
cord-022313-2675sjlf	163	4	first	first	JJ
cord-022313-2675sjlf	163	5	neutral	neutral	JJ
cord-022313-2675sjlf	163	6	α	α	NN
cord-022313-2675sjlf	163	7	-	-	HYPH
cord-022313-2675sjlf	163	8	mannosidase	mannosidase	NN
cord-022313-2675sjlf	163	9	to	to	TO
cord-022313-2675sjlf	163	10	be	be	VB
cord-022313-2675sjlf	163	11	reported	report	VBN
cord-022313-2675sjlf	163	12	was	be	VBD
cord-022313-2675sjlf	163	13	named	name	VBN
cord-022313-2675sjlf	163	14	mannosidase	mannosidase	NN
cord-022313-2675sjlf	163	15	I	I	NNP
cord-022313-2675sjlf	163	16	and	and	CC
cord-022313-2675sjlf	163	17	this	this	DT
cord-022313-2675sjlf	163	18	enzyme	enzyme	NN
cord-022313-2675sjlf	163	19	was	be	VBD
cord-022313-2675sjlf	163	20	isolated	isolate	VBN
cord-022313-2675sjlf	163	21	from	from	IN
cord-022313-2675sjlf	163	22	the	the	DT
cord-022313-2675sjlf	163	23	Golgi	Golgi	NNP
cord-022313-2675sjlf	163	24	apparatus	apparatus	NN
cord-022313-2675sjlf	163	25	of	of	IN
cord-022313-2675sjlf	163	26	eucaryotic	eucaryotic	JJ
cord-022313-2675sjlf	163	27	cells	cell	NNS
cord-022313-2675sjlf	163	28	(	(	-LRB-
cord-022313-2675sjlf	163	29	78	78	CD
cord-022313-2675sjlf	163	30	)	)	-RRB-
cord-022313-2675sjlf	163	31	.	.	.
cord-022313-2675sjlf	164	1	This	this	DT
cord-022313-2675sjlf	164	2	α	α	NN
cord-022313-2675sjlf	164	3	-	-	HYPH
cord-022313-2675sjlf	164	4	mannosidase	mannosidase	NN
cord-022313-2675sjlf	164	5	has	have	VBZ
cord-022313-2675sjlf	164	6	catalytic	catalytic	JJ
cord-022313-2675sjlf	164	7	properties	property	NNS
cord-022313-2675sjlf	164	8	very	very	RB
cord-022313-2675sjlf	164	9	similar	similar	JJ
cord-022313-2675sjlf	164	10	to	to	IN
cord-022313-2675sjlf	164	11	those	those	DT
cord-022313-2675sjlf	164	12	of	of	IN
cord-022313-2675sjlf	164	13	the	the	DT
cord-022313-2675sjlf	164	14	Ca	Ca	NNP
cord-022313-2675sjlf	164	15	2	2	CD
cord-022313-2675sjlf	164	16	+	+	SYM
cord-022313-2675sjlf	164	17	-dependent	-dependent	JJ
cord-022313-2675sjlf	164	18	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	164	19	,	,	,
cord-022313-2675sjlf	164	20	but	but	CC
cord-022313-2675sjlf	164	21	it	-PRON-	PRP
cord-022313-2675sjlf	164	22	apparantly	apparantly	RB
cord-022313-2675sjlf	164	23	does	do	VBZ
cord-022313-2675sjlf	164	24	not	not	RB
cord-022313-2675sjlf	164	25	need	need	VB
cord-022313-2675sjlf	164	26	Ca	Ca	NNP
cord-022313-2675sjlf	164	27	2	2	CD
cord-022313-2675sjlf	165	1	+	+	UH
cord-022313-2675sjlf	165	2	,	,	,
cord-022313-2675sjlf	165	3	although	although	IN
cord-022313-2675sjlf	165	4	this	this	DT
cord-022313-2675sjlf	165	5	is	be	VBZ
cord-022313-2675sjlf	165	6	not	not	RB
cord-022313-2675sjlf	165	7	certain	certain	JJ
cord-022313-2675sjlf	165	8	because	because	IN
cord-022313-2675sjlf	165	9	the	the	DT
cord-022313-2675sjlf	165	10	requirement	requirement	NN
cord-022313-2675sjlf	165	11	was	be	VBD
cord-022313-2675sjlf	165	12	not	not	RB
cord-022313-2675sjlf	165	13	tested	test	VBN
cord-022313-2675sjlf	165	14	in	in	IN
cord-022313-2675sjlf	165	15	the	the	DT
cord-022313-2675sjlf	165	16	presence	presence	NN
cord-022313-2675sjlf	165	17	of	of	IN
cord-022313-2675sjlf	165	18	EDTA	EDTA	NNP
cord-022313-2675sjlf	165	19	(	(	-LRB-
cord-022313-2675sjlf	165	20	79	79	CD
cord-022313-2675sjlf	165	21	)	)	-RRB-
cord-022313-2675sjlf	165	22	.	.	.
cord-022313-2675sjlf	166	1	The	the	DT
cord-022313-2675sjlf	166	2	mannosi	mannosi	NNP
cord-022313-2675sjlf	166	3	-	-	HYPH
cord-022313-2675sjlf	166	4	dase	dase	NNP
cord-022313-2675sjlf	167	1	I	-PRON-	PRP
cord-022313-2675sjlf	167	2	was	be	VBD
cord-022313-2675sjlf	167	3	resolved	resolve	VBN
cord-022313-2675sjlf	167	4	into	into	IN
cord-022313-2675sjlf	167	5	two	two	CD
cord-022313-2675sjlf	167	6	distinct	distinct	JJ
cord-022313-2675sjlf	167	7	proteins	protein	NNS
cord-022313-2675sjlf	167	8	by	by	IN
cord-022313-2675sjlf	167	9	chromatographic	chromatographic	JJ
cord-022313-2675sjlf	167	10	meth	meth	NNS
cord-022313-2675sjlf	167	11	ods	od	NNS
cord-022313-2675sjlf	167	12	and	and	CC
cord-022313-2675sjlf	167	13	these	these	DT
cord-022313-2675sjlf	167	14	two	two	CD
cord-022313-2675sjlf	167	15	forms	form	NNS
cord-022313-2675sjlf	167	16	were	be	VBD
cord-022313-2675sjlf	167	17	termed	term	VBN
cord-022313-2675sjlf	167	18	mannosidase	mannosidase	NN
cord-022313-2675sjlf	167	19	IA	IA	NNP
cord-022313-2675sjlf	167	20	and	and	CC
cord-022313-2675sjlf	167	21	IB	IB	NNP
cord-022313-2675sjlf	167	22	.	.	.
cord-022313-2675sjlf	168	1	IA	IA	NNP
cord-022313-2675sjlf	168	2	was	be	VBD
cord-022313-2675sjlf	168	3	purified	purify	VBN
cord-022313-2675sjlf	168	4	to	to	IN
cord-022313-2675sjlf	168	5	homogeneity	homogeneity	NN
cord-022313-2675sjlf	168	6	and	and	CC
cord-022313-2675sjlf	168	7	shown	show	VBN
cord-022313-2675sjlf	168	8	to	to	TO
cord-022313-2675sjlf	168	9	be	be	VB
cord-022313-2675sjlf	168	10	a	a	DT
cord-022313-2675sjlf	168	11	tetramer	tetramer	NN
cord-022313-2675sjlf	168	12	composed	compose	VBN
cord-022313-2675sjlf	168	13	of	of	IN
cord-022313-2675sjlf	168	14	56	56	CD
cord-022313-2675sjlf	168	15	kDa	kDa	NNS
cord-022313-2675sjlf	168	16	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	168	17	subunits	subunit	NNS
cord-022313-2675sjlf	168	18	(	(	-LRB-
cord-022313-2675sjlf	168	19	80	80	CD
cord-022313-2675sjlf	168	20	)	)	-RRB-
cord-022313-2675sjlf	168	21	.	.	.
cord-022313-2675sjlf	169	1	Presumably	presumably	RB
cord-022313-2675sjlf	169	2	IA	IA	NNP
cord-022313-2675sjlf	169	3	and	and	CC
cord-022313-2675sjlf	169	4	IB	IB	NNP
cord-022313-2675sjlf	169	5	have	have	VBP
cord-022313-2675sjlf	169	6	similar	similar	JJ
cord-022313-2675sjlf	169	7	substrate	substrate	NN
cord-022313-2675sjlf	169	8	specificities	specificity	NNS
cord-022313-2675sjlf	169	9	,	,	,
cord-022313-2675sjlf	169	10	but	but	CC
cord-022313-2675sjlf	169	11	it	-PRON-	PRP
cord-022313-2675sjlf	169	12	is	be	VBZ
cord-022313-2675sjlf	169	13	not	not	RB
cord-022313-2675sjlf	169	14	clear	clear	JJ
cord-022313-2675sjlf	169	15	if	if	IN
cord-022313-2675sjlf	169	16	they	-PRON-	PRP
cord-022313-2675sjlf	169	17	are	be	VBP
cord-022313-2675sjlf	169	18	derived	derive	VBN
cord-022313-2675sjlf	169	19	from	from	IN
cord-022313-2675sjlf	169	20	the	the	DT
cord-022313-2675sjlf	169	21	same	same	JJ
cord-022313-2675sjlf	169	22	gene	gene	NN
cord-022313-2675sjlf	169	23	.	.	.
cord-022313-2675sjlf	170	1	Once	once	IN
cord-022313-2675sjlf	170	2	the	the	DT
cord-022313-2675sjlf	170	3	four	four	CD
cord-022313-2675sjlf	170	4	al,2-linked	al,2-linked	JJ
cord-022313-2675sjlf	170	5	mannose	mannose	NN
cord-022313-2675sjlf	170	6	units	unit	NNS
cord-022313-2675sjlf	170	7	are	be	VBP
cord-022313-2675sjlf	170	8	removed	remove	VBN
cord-022313-2675sjlf	170	9	,	,	,
cord-022313-2675sjlf	170	10	a	a	DT
cord-022313-2675sjlf	170	11	medial	medial	JJ
cord-022313-2675sjlf	170	12	Golgi	Golgi	NNP
cord-022313-2675sjlf	170	13	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	170	14	transferase	transferase	NN
cord-022313-2675sjlf	170	15	(	(	-LRB-
cord-022313-2675sjlf	170	16	called	call	VBN
cord-022313-2675sjlf	170	17	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	170	18	transferase	transferase	NN
cord-022313-2675sjlf	170	19	I	I	NNP
cord-022313-2675sjlf	170	20	)	)	-RRB-
cord-022313-2675sjlf	170	21	adds	add	VBZ
cord-022313-2675sjlf	170	22	a	a	DT
cord-022313-2675sjlf	170	23	GlcNAc	glcnac	NN
cord-022313-2675sjlf	170	24	from	from	IN
cord-022313-2675sjlf	170	25	UDP	UDP	NNP
cord-022313-2675sjlf	170	26	-	-	HYPH
cord-022313-2675sjlf	170	27	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	170	28	to	to	IN
cord-022313-2675sjlf	170	29	the	the	DT
cord-022313-2675sjlf	170	30	mannose	mannose	NN
cord-022313-2675sjlf	170	31	that	that	WDT
cord-022313-2675sjlf	170	32	is	be	VBZ
cord-022313-2675sjlf	170	33	attached	attach	VBN
cord-022313-2675sjlf	170	34	to	to	IN
cord-022313-2675sjlf	170	35	the	the	DT
cord-022313-2675sjlf	170	36	β	β	NN
cord-022313-2675sjlf	170	37	-	-	HYPH
cord-022313-2675sjlf	170	38	linked	link	VBN
cord-022313-2675sjlf	170	39	mannose	mannose	NN
cord-022313-2675sjlf	170	40	in	in	IN
cord-022313-2675sjlf	170	41	al	al	NNP
cord-022313-2675sjlf	170	42	,	,	,
cord-022313-2675sjlf	170	43	3-linkage	3-linkage	NNP
cord-022313-2675sjlf	170	44	(	(	-LRB-
cord-022313-2675sjlf	170	45	81	81	CD
cord-022313-2675sjlf	170	46	)	)	-RRB-
cord-022313-2675sjlf	170	47	.	.	.
cord-022313-2675sjlf	171	1	This	this	DT
cord-022313-2675sjlf	171	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	171	3	transferase	transferase	NN
cord-022313-2675sjlf	171	4	was	be	VBD
cord-022313-2675sjlf	171	5	purified	purify	VBN
cord-022313-2675sjlf	171	6	over	over	IN
cord-022313-2675sjlf	171	7	100,000-fold	100,000-fold	CD
cord-022313-2675sjlf	171	8	to	to	IN
cord-022313-2675sjlf	171	9	homogeneity	homogeneity	NN
cord-022313-2675sjlf	171	10	from	from	IN
cord-022313-2675sjlf	171	11	liver	liver	NN
cord-022313-2675sjlf	171	12	(	(	-LRB-
cord-022313-2675sjlf	171	13	82	82	CD
cord-022313-2675sjlf	171	14	)	)	-RRB-
cord-022313-2675sjlf	171	15	and	and	CC
cord-022313-2675sjlf	171	16	the	the	DT
cord-022313-2675sjlf	171	17	enzyme	enzyme	NN
cord-022313-2675sjlf	171	18	has	have	VBZ
cord-022313-2675sjlf	171	19	been	be	VBN
cord-022313-2675sjlf	171	20	sequenced	sequence	VBN
cord-022313-2675sjlf	171	21	and	and	CC
cord-022313-2675sjlf	171	22	cloned	clone	VBN
cord-022313-2675sjlf	171	23	(	(	-LRB-
cord-022313-2675sjlf	171	24	83	83	CD
cord-022313-2675sjlf	171	25	)	)	-RRB-
cord-022313-2675sjlf	171	26	.	.	.
cord-022313-2675sjlf	172	1	The	the	DT
cord-022313-2675sjlf	172	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	172	3	is	be	VBZ
cord-022313-2675sjlf	172	4	apparantly	apparantly	RB
cord-022313-2675sjlf	172	5	a	a	DT
cord-022313-2675sjlf	172	6	recognition	recognition	NN
cord-022313-2675sjlf	172	7	signal	signal	NN
cord-022313-2675sjlf	172	8	for	for	IN
cord-022313-2675sjlf	172	9	another	another	DT
cord-022313-2675sjlf	172	10	highly	highly	RB
cord-022313-2675sjlf	172	11	specific	specific	JJ
cord-022313-2675sjlf	172	12	α	α	NN
cord-022313-2675sjlf	172	13	-	-	HYPH
cord-022313-2675sjlf	172	14	mannosidase	mannosidase	NN
cord-022313-2675sjlf	172	15	,	,	,
cord-022313-2675sjlf	172	16	called	call	VBN
cord-022313-2675sjlf	172	17	mannosidase	mannosidase	NN
cord-022313-2675sjlf	172	18	II	II	NNP
cord-022313-2675sjlf	172	19	,	,	,
cord-022313-2675sjlf	172	20	that	that	WDT
cord-022313-2675sjlf	172	21	cleaves	cleave	VBZ
cord-022313-2675sjlf	172	22	the	the	DT
cord-022313-2675sjlf	172	23	al,3-linked	al,3-linked	NNP
cord-022313-2675sjlf	172	24	and	and	CC
cord-022313-2675sjlf	172	25	al,6-linked	al,6-linked	NNP
cord-022313-2675sjlf	172	26	mannoses	mannose	NNS
cord-022313-2675sjlf	172	27	from	from	IN
cord-022313-2675sjlf	172	28	the	the	DT
cord-022313-2675sjlf	172	29	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	172	30	-	-	HYPH
cord-022313-2675sjlf	172	31	Man	Man	NNP
cord-022313-2675sjlf	172	32	5	5	CD
cord-022313-2675sjlf	173	1	(	(	-LRB-
cord-022313-2675sjlf	173	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	173	3	)	)	-RRB-
cord-022313-2675sjlf	173	4	2	2	CD
cord-022313-2675sjlf	173	5	-protein	-protein	NN
cord-022313-2675sjlf	173	6	to	to	TO
cord-022313-2675sjlf	173	7	give	give	VB
cord-022313-2675sjlf	173	8	a	a	DT
cord-022313-2675sjlf	173	9	GlcNAc/31,2Manal	glcnac/31,2manal	NN
cord-022313-2675sjlf	173	10	,	,	,
cord-022313-2675sjlf	173	11	3[Manal,6]Manj31,4GlcNAc)81,4GlcNAc	3[manal,6]manj31,4glcnac)81,4glcnac	CD
cord-022313-2675sjlf	173	12	-	-	HYPH
cord-022313-2675sjlf	173	13	protein	protein	NN
cord-022313-2675sjlf	173	14	(	(	-LRB-
cord-022313-2675sjlf	173	15	84	84	CD
cord-022313-2675sjlf	173	16	)	)	-RRB-
cord-022313-2675sjlf	173	17	.	.	.
cord-022313-2675sjlf	174	1	In	in	IN
cord-022313-2675sjlf	174	2	spite	spite	NN
cord-022313-2675sjlf	174	3	of	of	IN
cord-022313-2675sjlf	174	4	this	this	DT
cord-022313-2675sjlf	174	5	substrate	substrate	NN
cord-022313-2675sjlf	174	6	specificity	specificity	NN
cord-022313-2675sjlf	174	7	,	,	,
cord-022313-2675sjlf	174	8	mannosidase	mannosidase	NN
cord-022313-2675sjlf	174	9	II	II	NNP
cord-022313-2675sjlf	174	10	does	do	VBZ
cord-022313-2675sjlf	174	11	act	act	VB
cord-022313-2675sjlf	174	12	on	on	IN
cord-022313-2675sjlf	174	13	the	the	DT
cord-022313-2675sjlf	174	14	aryl	aryl	NN
cord-022313-2675sjlf	174	15	-	-	HYPH
cord-022313-2675sjlf	174	16	a	a	NN
cord-022313-2675sjlf	174	17	-	-	HYPH
cord-022313-2675sjlf	174	18	mannopyranosides	mannopyranoside	NNS
cord-022313-2675sjlf	174	19	such	such	JJ
cord-022313-2675sjlf	174	20	as	as	IN
cord-022313-2675sjlf	174	21	p	p	NN
cord-022313-2675sjlf	174	22	-	-	HYPH
cord-022313-2675sjlf	174	23	nitrophenyl	nitrophenyl	NN
cord-022313-2675sjlf	174	24	-	-	HYPH
cord-022313-2675sjlf	174	25	a	a	DT
cord-022313-2675sjlf	174	26	-	-	HYPH
cord-022313-2675sjlf	174	27	D	d	NN
cord-022313-2675sjlf	174	28	-	-	HYPH
cord-022313-2675sjlf	174	29	mannopyranoside	mannopyranoside	NN
cord-022313-2675sjlf	174	30	.	.	.
cord-022313-2675sjlf	175	1	Mannosidase	Mannosidase	NNP
cord-022313-2675sjlf	175	2	II	II	NNP
cord-022313-2675sjlf	175	3	was	be	VBD
cord-022313-2675sjlf	175	4	purified	purify	VBN
cord-022313-2675sjlf	175	5	to	to	IN
cord-022313-2675sjlf	175	6	homogeneity	homogeneity	NN
cord-022313-2675sjlf	175	7	from	from	IN
cord-022313-2675sjlf	175	8	rat	rat	NN
cord-022313-2675sjlf	175	9	liver	liver	NN
cord-022313-2675sjlf	175	10	(	(	-LRB-
cord-022313-2675sjlf	175	11	85	85	CD
cord-022313-2675sjlf	175	12	,	,	,
cord-022313-2675sjlf	175	13	86	86	CD
cord-022313-2675sjlf	175	14	)	)	-RRB-
cord-022313-2675sjlf	175	15	and	and	CC
cord-022313-2675sjlf	175	16	from	from	IN
cord-022313-2675sjlf	175	17	mung	mung	NN
cord-022313-2675sjlf	175	18	bean	bean	NN
cord-022313-2675sjlf	175	19	seedlings	seedling	NNS
cord-022313-2675sjlf	175	20	(	(	-LRB-
cord-022313-2675sjlf	175	21	87	87	CD
cord-022313-2675sjlf	175	22	)	)	-RRB-
cord-022313-2675sjlf	175	23	.	.	.
cord-022313-2675sjlf	176	1	Both	both	DT
cord-022313-2675sjlf	176	2	enzymes	enzyme	NNS
cord-022313-2675sjlf	176	3	migrate	migrate	VBP
cord-022313-2675sjlf	176	4	on	on	IN
cord-022313-2675sjlf	176	5	SDS	SDS	NNP
cord-022313-2675sjlf	176	6	gels	gel	NNS
cord-022313-2675sjlf	176	7	as	as	IN
cord-022313-2675sjlf	176	8	proteins	protein	NNS
cord-022313-2675sjlf	176	9	of	of	IN
cord-022313-2675sjlf	176	10	about	about	RB
cord-022313-2675sjlf	176	11	125	125	CD
cord-022313-2675sjlf	176	12	kDa	kDa	NNS
cord-022313-2675sjlf	176	13	,	,	,
cord-022313-2675sjlf	176	14	although	although	IN
cord-022313-2675sjlf	176	15	the	the	DT
cord-022313-2675sjlf	176	16	sequence	sequence	NN
cord-022313-2675sjlf	176	17	for	for	IN
cord-022313-2675sjlf	176	18	the	the	DT
cord-022313-2675sjlf	176	19	murine	murine	JJ
cord-022313-2675sjlf	176	20	enzyme	enzyme	NN
cord-022313-2675sjlf	176	21	predicts	predict	VBZ
cord-022313-2675sjlf	176	22	a	a	DT
cord-022313-2675sjlf	176	23	MW	MW	NNP
cord-022313-2675sjlf	176	24	of	of	IN
cord-022313-2675sjlf	176	25	132	132	CD
cord-022313-2675sjlf	176	26	kDa	kDa	NNS
cord-022313-2675sjlf	176	27	for	for	IN
cord-022313-2675sjlf	176	28	the	the	DT
cord-022313-2675sjlf	176	29	deglycosylated	deglycosylated	JJ
cord-022313-2675sjlf	176	30	protein	protein	NN
cord-022313-2675sjlf	176	31	.	.	.
cord-022313-2675sjlf	177	1	Both	both	DT
cord-022313-2675sjlf	177	2	enzymes	enzyme	NNS
cord-022313-2675sjlf	177	3	are	be	VBP
cord-022313-2675sjlf	177	4	also	also	RB
cord-022313-2675sjlf	177	5	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	177	6	and	and	CC
cord-022313-2675sjlf	177	7	the	the	DT
cord-022313-2675sjlf	177	8	murine	murine	JJ
cord-022313-2675sjlf	177	9	enzyme	enzyme	NN
cord-022313-2675sjlf	177	10	has	have	VBZ
cord-022313-2675sjlf	177	11	been	be	VBN
cord-022313-2675sjlf	177	12	shown	show	VBN
cord-022313-2675sjlf	177	13	to	to	TO
cord-022313-2675sjlf	177	14	be	be	VB
cord-022313-2675sjlf	177	15	a	a	DT
cord-022313-2675sjlf	177	16	type	type	NN
cord-022313-2675sjlf	177	17	II	ii	NN
cord-022313-2675sjlf	177	18	transmembrane	transmembrane	NN
cord-022313-2675sjlf	177	19	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	177	20	with	with	IN
cord-022313-2675sjlf	177	21	a	a	DT
cord-022313-2675sjlf	177	22	single	single	JJ
cord-022313-2675sjlf	177	23	transmembrane	transmembrane	NN
cord-022313-2675sjlf	177	24	region	region	NN
cord-022313-2675sjlf	177	25	and	and	CC
cord-022313-2675sjlf	177	26	a	a	DT
cord-022313-2675sjlf	177	27	luminally	luminally	RB
cord-022313-2675sjlf	177	28	oriented	orient	VBN
cord-022313-2675sjlf	177	29	catalytic	catalytic	JJ
cord-022313-2675sjlf	177	30	site	site	NN
cord-022313-2675sjlf	177	31	(	(	-LRB-
cord-022313-2675sjlf	177	32	88	88	CD
cord-022313-2675sjlf	177	33	)	)	-RRB-
cord-022313-2675sjlf	177	34	.	.	.
cord-022313-2675sjlf	178	1	There	there	EX
cord-022313-2675sjlf	178	2	are	be	VBP
cord-022313-2675sjlf	178	3	several	several	JJ
cord-022313-2675sjlf	178	4	other	other	JJ
cord-022313-2675sjlf	178	5	α	α	NN
cord-022313-2675sjlf	178	6	-	-	HYPH
cord-022313-2675sjlf	178	7	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	178	8	that	that	WDT
cord-022313-2675sjlf	178	9	are	be	VBP
cord-022313-2675sjlf	178	10	distinct	distinct	JJ
cord-022313-2675sjlf	178	11	from	from	IN
cord-022313-2675sjlf	178	12	the	the	DT
cord-022313-2675sjlf	178	13	above	above	JJ
cord-022313-2675sjlf	178	14	enzymes	enzyme	NNS
cord-022313-2675sjlf	178	15	based	base	VBN
cord-022313-2675sjlf	178	16	on	on	IN
cord-022313-2675sjlf	178	17	their	-PRON-	PRP$
cord-022313-2675sjlf	178	18	sensitivity	sensitivity	NN
cord-022313-2675sjlf	178	19	to	to	IN
cord-022313-2675sjlf	178	20	processing	processing	NN
cord-022313-2675sjlf	178	21	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	178	22	and	and	CC
cord-022313-2675sjlf	178	23	to	to	IN
cord-022313-2675sjlf	178	24	catalysis	catalysis	NN
cord-022313-2675sjlf	178	25	of	of	IN
cord-022313-2675sjlf	178	26	high	high	JJ
cord-022313-2675sjlf	178	27	-	-	HYPH
cord-022313-2675sjlf	178	28	mannose	mannose	NN
cord-022313-2675sjlf	178	29	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	178	30	.	.	.
cord-022313-2675sjlf	179	1	However	however	RB
cord-022313-2675sjlf	179	2	,	,	,
cord-022313-2675sjlf	179	3	the	the	DT
cord-022313-2675sjlf	179	4	relative	relative	JJ
cord-022313-2675sjlf	179	5	role	role	NN
cord-022313-2675sjlf	179	6	of	of	IN
cord-022313-2675sjlf	179	7	these	these	DT
cord-022313-2675sjlf	179	8	enzymes	enzyme	NNS
cord-022313-2675sjlf	179	9	in	in	IN
cord-022313-2675sjlf	179	10	the	the	DT
cord-022313-2675sjlf	179	11	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	179	12	processing	process	VBG
cord-022313-2675sjlf	179	13	pathway	pathway	NN
cord-022313-2675sjlf	179	14	remains	remain	VBZ
cord-022313-2675sjlf	179	15	to	to	TO
cord-022313-2675sjlf	179	16	be	be	VB
cord-022313-2675sjlf	179	17	established	establish	VBN
cord-022313-2675sjlf	179	18	.	.	.
cord-022313-2675sjlf	180	1	One	one	CD
cord-022313-2675sjlf	180	2	of	of	IN
cord-022313-2675sjlf	180	3	these	these	DT
cord-022313-2675sjlf	180	4	enzymes	enzyme	NNS
cord-022313-2675sjlf	180	5	is	be	VBZ
cord-022313-2675sjlf	180	6	a	a	DT
cord-022313-2675sjlf	180	7	cytosolic	cytosolic	JJ
cord-022313-2675sjlf	180	8	and	and	CC
cord-022313-2675sjlf	180	9	neutral	neutral	JJ
cord-022313-2675sjlf	180	10	amannosidase	amannosidase	NN
cord-022313-2675sjlf	180	11	from	from	IN
cord-022313-2675sjlf	180	12	rat	rat	NN
cord-022313-2675sjlf	180	13	liver	liver	NN
cord-022313-2675sjlf	180	14	(	(	-LRB-
cord-022313-2675sjlf	180	15	89	89	CD
cord-022313-2675sjlf	180	16	)	)	-RRB-
cord-022313-2675sjlf	180	17	.	.	.
cord-022313-2675sjlf	181	1	Although	although	IN
cord-022313-2675sjlf	181	2	it	-PRON-	PRP
cord-022313-2675sjlf	181	3	was	be	VBD
cord-022313-2675sjlf	181	4	originally	originally	RB
cord-022313-2675sjlf	181	5	thought	think	VBN
cord-022313-2675sjlf	181	6	that	that	IN
cord-022313-2675sjlf	181	7	this	this	DT
cord-022313-2675sjlf	181	8	enzyme	enzyme	NN
cord-022313-2675sjlf	181	9	was	be	VBD
cord-022313-2675sjlf	181	10	a	a	DT
cord-022313-2675sjlf	181	11	proteolytic	proteolytic	JJ
cord-022313-2675sjlf	181	12	product	product	NN
cord-022313-2675sjlf	181	13	of	of	IN
cord-022313-2675sjlf	181	14	an	an	DT
cord-022313-2675sjlf	181	15	ER	ER	NNP
cord-022313-2675sjlf	181	16	a	a	NNP
cord-022313-2675sjlf	181	17	-	-	HYPH
cord-022313-2675sjlf	181	18	mannosidase	mannosidase	NN
cord-022313-2675sjlf	181	19	,	,	,
cord-022313-2675sjlf	181	20	it	-PRON-	PRP
cord-022313-2675sjlf	181	21	now	now	RB
cord-022313-2675sjlf	181	22	appears	appear	VBZ
cord-022313-2675sjlf	181	23	that	that	IN
cord-022313-2675sjlf	181	24	both	both	CC
cord-022313-2675sjlf	181	25	the	the	DT
cord-022313-2675sjlf	181	26	cytosolic	cytosolic	JJ
cord-022313-2675sjlf	181	27	and	and	CC
cord-022313-2675sjlf	181	28	the	the	DT
cord-022313-2675sjlf	181	29	ER	ER	NNP
cord-022313-2675sjlf	181	30	α	α	NN
cord-022313-2675sjlf	181	31	-	-	HYPH
cord-022313-2675sjlf	181	32	mannosidase	mannosidase	NNP
cord-022313-2675sjlf	181	33	are	be	VBP
cord-022313-2675sjlf	181	34	related	relate	VBN
cord-022313-2675sjlf	181	35	to	to	IN
cord-022313-2675sjlf	181	36	an	an	DT
cord-022313-2675sjlf	181	37	α	α	NN
cord-022313-2675sjlf	181	38	-	-	HYPH
cord-022313-2675sjlf	181	39	mannosidase	mannosidase	NN
cord-022313-2675sjlf	181	40	that	that	WDT
cord-022313-2675sjlf	181	41	was	be	VBD
cord-022313-2675sjlf	181	42	isolated	isolate	VBN
cord-022313-2675sjlf	181	43	from	from	IN
cord-022313-2675sjlf	181	44	rat	rat	NN
cord-022313-2675sjlf	181	45	brain	brain	NN
cord-022313-2675sjlf	181	46	and	and	CC
cord-022313-2675sjlf	181	47	that	that	WDT
cord-022313-2675sjlf	181	48	can	can	MD
cord-022313-2675sjlf	181	49	cleave	cleave	VB
cord-022313-2675sjlf	181	50	al,2-	al,2-	CD
cord-022313-2675sjlf	181	51	,	,	,
cord-022313-2675sjlf	181	52	αϊ,3-	αϊ,3-	XX
cord-022313-2675sjlf	181	53	,	,	,
cord-022313-2675sjlf	181	54	and	and	CC
cord-022313-2675sjlf	181	55	al,6-linked	al,6-linked	JJ
cord-022313-2675sjlf	181	56	mannose	mannose	NN
cord-022313-2675sjlf	181	57	residues	residue	NNS
cord-022313-2675sjlf	181	58	(	(	-LRB-
cord-022313-2675sjlf	181	59	90	90	CD
cord-022313-2675sjlf	181	60	)	)	-RRB-
cord-022313-2675sjlf	181	61	.	.	.
cord-022313-2675sjlf	182	1	This	this	DT
cord-022313-2675sjlf	182	2	last	last	JJ
cord-022313-2675sjlf	182	3	enzyme	enzyme	NN
cord-022313-2675sjlf	182	4	can	can	MD
cord-022313-2675sjlf	182	5	cleave	cleave	VB
cord-022313-2675sjlf	182	6	a	a	DT
cord-022313-2675sjlf	182	7	Man	man	NN
cord-022313-2675sjlf	182	8	9	9	CD
cord-022313-2675sjlf	183	1	(	(	-LRB-
cord-022313-2675sjlf	183	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	183	3	)	)	-RRB-
cord-022313-2675sjlf	183	4	2	2	CD
cord-022313-2675sjlf	183	5	structure	structure	NN
cord-022313-2675sjlf	183	6	to	to	IN
cord-022313-2675sjlf	183	7	a	a	DT
cord-022313-2675sjlf	183	8	Man	Man	NNP
cord-022313-2675sjlf	183	9	3	3	CD
cord-022313-2675sjlf	183	10	(	(	-LRB-
cord-022313-2675sjlf	183	11	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	183	12	)	)	-RRB-
cord-022313-2675sjlf	183	13	2	2	CD
cord-022313-2675sjlf	183	14	.	.	.
cord-022313-2675sjlf	184	1	The	the	DT
cord-022313-2675sjlf	184	2	difference	difference	NN
cord-022313-2675sjlf	184	3	between	between	IN
cord-022313-2675sjlf	184	4	the	the	DT
cord-022313-2675sjlf	184	5	ER	ER	NNP
cord-022313-2675sjlf	184	6	liver	liver	NN
cord-022313-2675sjlf	184	7	enzyme	enzyme	NN
cord-022313-2675sjlf	184	8	and	and	CC
cord-022313-2675sjlf	184	9	the	the	DT
cord-022313-2675sjlf	184	10	brain	brain	NN
cord-022313-2675sjlf	184	11	enzyme	enzyme	NN
cord-022313-2675sjlf	184	12	is	be	VBZ
cord-022313-2675sjlf	184	13	that	that	IN
cord-022313-2675sjlf	184	14	the	the	DT
cord-022313-2675sjlf	184	15	former	former	JJ
cord-022313-2675sjlf	184	16	enzyme	enzyme	NN
cord-022313-2675sjlf	184	17	is	be	VBZ
cord-022313-2675sjlf	184	18	also	also	RB
cord-022313-2675sjlf	184	19	active	active	JJ
cord-022313-2675sjlf	184	20	with	with	IN
cord-022313-2675sjlf	184	21	aryl	aryl	RB
cord-022313-2675sjlf	184	22	-	-	HYPH
cord-022313-2675sjlf	184	23	a	a	DT
cord-022313-2675sjlf	184	24	-	-	HYPH
cord-022313-2675sjlf	184	25	mannosides	mannoside	NNS
cord-022313-2675sjlf	184	26	,	,	,
cord-022313-2675sjlf	184	27	whereas	whereas	IN
cord-022313-2675sjlf	184	28	the	the	DT
cord-022313-2675sjlf	184	29	latter	latter	NN
cord-022313-2675sjlf	184	30	is	be	VBZ
cord-022313-2675sjlf	184	31	not	not	RB
cord-022313-2675sjlf	184	32	.	.	.
cord-022313-2675sjlf	185	1	Two	two	CD
cord-022313-2675sjlf	185	2	other	other	JJ
cord-022313-2675sjlf	185	3	α	α	NN
cord-022313-2675sjlf	185	4	-	-	HYPH
cord-022313-2675sjlf	185	5	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	185	6	that	that	WDT
cord-022313-2675sjlf	185	7	can	can	MD
cord-022313-2675sjlf	185	8	cleave	cleave	VB
cord-022313-2675sjlf	185	9	al,2-	al,2-	NNP
cord-022313-2675sjlf	185	10	,	,	,
cord-022313-2675sjlf	185	11	al,3-	al,3-	CD
cord-022313-2675sjlf	185	12	,	,	,
cord-022313-2675sjlf	185	13	and	and	CC
cord-022313-2675sjlf	185	14	al,6-linked	al,6-linked	NNP
cord-022313-2675sjlf	185	15	mannoses	mannose	NNS
cord-022313-2675sjlf	185	16	have	have	VBP
cord-022313-2675sjlf	185	17	been	be	VBN
cord-022313-2675sjlf	185	18	purified	purify	VBN
cord-022313-2675sjlf	185	19	from	from	IN
cord-022313-2675sjlf	185	20	rat	rat	NN
cord-022313-2675sjlf	185	21	sperm	sperm	NN
cord-022313-2675sjlf	185	22	(	(	-LRB-
cord-022313-2675sjlf	185	23	91	91	CD
cord-022313-2675sjlf	185	24	)	)	-RRB-
cord-022313-2675sjlf	185	25	and	and	CC
cord-022313-2675sjlf	185	26	rat	rat	NN
cord-022313-2675sjlf	185	27	liver	liver	NN
cord-022313-2675sjlf	185	28	(	(	-LRB-
cord-022313-2675sjlf	185	29	92	92	CD
cord-022313-2675sjlf	185	30	)	)	-RRB-
cord-022313-2675sjlf	185	31	.	.	.
cord-022313-2675sjlf	186	1	Another	another	DT
cord-022313-2675sjlf	186	2	type	type	NN
cord-022313-2675sjlf	186	3	of	of	IN
cord-022313-2675sjlf	186	4	hydrolytic	hydrolytic	JJ
cord-022313-2675sjlf	186	5	enzyme	enzyme	NN
cord-022313-2675sjlf	186	6	that	that	WDT
cord-022313-2675sjlf	186	7	is	be	VBZ
cord-022313-2675sjlf	186	8	also	also	RB
cord-022313-2675sjlf	186	9	proposed	propose	VBN
cord-022313-2675sjlf	186	10	to	to	TO
cord-022313-2675sjlf	186	11	be	be	VB
cord-022313-2675sjlf	186	12	involved	involve	VBN
cord-022313-2675sjlf	186	13	in	in	IN
cord-022313-2675sjlf	186	14	processing	processing	NN
cord-022313-2675sjlf	186	15	is	be	VBZ
cord-022313-2675sjlf	186	16	an	an	DT
cord-022313-2675sjlf	186	17	endo	endo	NN
cord-022313-2675sjlf	186	18	-	-	HYPH
cord-022313-2675sjlf	186	19	a	a	DT
cord-022313-2675sjlf	186	20	-	-	HYPH
cord-022313-2675sjlf	186	21	mannosidase	mannosidase	NN
cord-022313-2675sjlf	186	22	that	that	WDT
cord-022313-2675sjlf	186	23	can	can	MD
cord-022313-2675sjlf	186	24	cleave	cleave	VB
cord-022313-2675sjlf	186	25	a	a	DT
cord-022313-2675sjlf	186	26	Glcal,3Man	Glcal,3Man	NNP
cord-022313-2675sjlf	186	27	disaccharide	disaccharide	NN
cord-022313-2675sjlf	186	28	from	from	IN
cord-022313-2675sjlf	186	29	Glc	Glc	NNP
cord-022313-2675sjlf	186	30	1	1	CD
cord-022313-2675sjlf	186	31	Man	Man	NNP
cord-022313-2675sjlf	186	32	9	9	CD
cord-022313-2675sjlf	186	33	(	(	-LRB-
cord-022313-2675sjlf	186	34	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	186	35	)	)	-RRB-
cord-022313-2675sjlf	186	36	2	2	CD
cord-022313-2675sjlf	186	37	(	(	-LRB-
cord-022313-2675sjlf	186	38	or	or	CC
cord-022313-2675sjlf	186	39	a	a	DT
cord-022313-2675sjlf	186	40	Glc	Glc	NNP
cord-022313-2675sjlf	186	41	3	3	CD
cord-022313-2675sjlf	186	42	Man	Man	NNP
cord-022313-2675sjlf	186	43	from	from	IN
cord-022313-2675sjlf	186	44	Glc	Glc	NNP
cord-022313-2675sjlf	186	45	3	3	CD
cord-022313-2675sjlf	186	46	Man	Man	NNP
cord-022313-2675sjlf	186	47	9	9	CD
cord-022313-2675sjlf	186	48	(	(	-LRB-
cord-022313-2675sjlf	186	49	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	186	50	)	)	-RRB-
cord-022313-2675sjlf	186	51	2	2	CD
cord-022313-2675sjlf	186	52	,	,	,
cord-022313-2675sjlf	186	53	etc	etc	FW
cord-022313-2675sjlf	186	54	.	.	.
cord-022313-2675sjlf	186	55	)	)	-RRB-
cord-022313-2675sjlf	187	1	(	(	-LRB-
cord-022313-2675sjlf	187	2	93	93	CD
cord-022313-2675sjlf	187	3	)	)	-RRB-
cord-022313-2675sjlf	187	4	.	.	.
cord-022313-2675sjlf	188	1	It	-PRON-	PRP
cord-022313-2675sjlf	188	2	is	be	VBZ
cord-022313-2675sjlf	188	3	interesting	interesting	JJ
cord-022313-2675sjlf	188	4	to	to	TO
cord-022313-2675sjlf	188	5	note	note	VB
cord-022313-2675sjlf	188	6	that	that	IN
cord-022313-2675sjlf	188	7	the	the	DT
cord-022313-2675sjlf	188	8	Man	Man	NNP
cord-022313-2675sjlf	188	9	8	8	CD
cord-022313-2675sjlf	188	10	(	(	-LRB-
cord-022313-2675sjlf	188	11	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	188	12	)	)	-RRB-
cord-022313-2675sjlf	188	13	2	2	CD
cord-022313-2675sjlf	188	14	that	that	WDT
cord-022313-2675sjlf	188	15	results	result	VBZ
cord-022313-2675sjlf	188	16	from	from	IN
cord-022313-2675sjlf	188	17	the	the	DT
cord-022313-2675sjlf	188	18	action	action	NN
cord-022313-2675sjlf	188	19	of	of	IN
cord-022313-2675sjlf	188	20	this	this	DT
cord-022313-2675sjlf	188	21	enzyme	enzyme	NN
cord-022313-2675sjlf	188	22	is	be	VBZ
cord-022313-2675sjlf	188	23	a	a	DT
cord-022313-2675sjlf	188	24	different	different	JJ
cord-022313-2675sjlf	188	25	isomer	isomer	NN
cord-022313-2675sjlf	188	26	from	from	IN
cord-022313-2675sjlf	188	27	the	the	DT
cord-022313-2675sjlf	188	28	Man	Man	NNP
cord-022313-2675sjlf	188	29	8	8	CD
cord-022313-2675sjlf	188	30	(	(	-LRB-
cord-022313-2675sjlf	188	31	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	188	32	)	)	-RRB-
cord-022313-2675sjlf	188	33	2	2	CD
cord-022313-2675sjlf	188	34	that	that	WDT
cord-022313-2675sjlf	188	35	is	be	VBZ
cord-022313-2675sjlf	188	36	formed	form	VBN
cord-022313-2675sjlf	188	37	by	by	IN
cord-022313-2675sjlf	188	38	the	the	DT
cord-022313-2675sjlf	188	39	action	action	NN
cord-022313-2675sjlf	188	40	of	of	IN
cord-022313-2675sjlf	188	41	the	the	DT
cord-022313-2675sjlf	188	42	ER	ER	NNP
cord-022313-2675sjlf	188	43	α	α	NNP
cord-022313-2675sjlf	188	44	-	-	HYPH
cord-022313-2675sjlf	188	45	mannosidase	mannosidase	NN
cord-022313-2675sjlf	188	46	or	or	CC
cord-022313-2675sjlf	188	47	the	the	DT
cord-022313-2675sjlf	188	48	yeast	yeast	NN
cord-022313-2675sjlf	188	49	α	α	NN
cord-022313-2675sjlf	188	50	-	-	HYPH
cord-022313-2675sjlf	188	51	mannosidase	mannosidase	NN
cord-022313-2675sjlf	188	52	(	(	-LRB-
cord-022313-2675sjlf	188	53	94	94	CD
cord-022313-2675sjlf	188	54	)	)	-RRB-
cord-022313-2675sjlf	188	55	.	.	.
cord-022313-2675sjlf	189	1	This	this	DT
cord-022313-2675sjlf	189	2	endomannosidase	endomannosidase	NN
cord-022313-2675sjlf	189	3	appears	appear	VBZ
cord-022313-2675sjlf	189	4	to	to	TO
cord-022313-2675sjlf	189	5	be	be	VB
cord-022313-2675sjlf	189	6	a	a	DT
cord-022313-2675sjlf	189	7	resident	resident	NN
cord-022313-2675sjlf	189	8	of	of	IN
cord-022313-2675sjlf	189	9	the	the	DT
cord-022313-2675sjlf	189	10	Golgi	Golgi	NNP
cord-022313-2675sjlf	189	11	apparatus	apparatus	NN
cord-022313-2675sjlf	189	12	and	and	CC
cord-022313-2675sjlf	189	13	may	may	MD
cord-022313-2675sjlf	189	14	function	function	VB
cord-022313-2675sjlf	189	15	to	to	TO
cord-022313-2675sjlf	189	16	trim	trim	VB
cord-022313-2675sjlf	189	17	oligosaccha	oligosaccha	NN
cord-022313-2675sjlf	189	18	rides	ride	NNS
cord-022313-2675sjlf	189	19	on	on	IN
cord-022313-2675sjlf	189	20	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	189	21	that	that	WDT
cord-022313-2675sjlf	189	22	have	have	VBP
cord-022313-2675sjlf	189	23	escaped	escape	VBN
cord-022313-2675sjlf	189	24	the	the	DT
cord-022313-2675sjlf	189	25	ER	ER	NNP
cord-022313-2675sjlf	189	26	still	still	RB
cord-022313-2675sjlf	189	27	retaining	retain	VBG
cord-022313-2675sjlf	189	28	one	one	CD
cord-022313-2675sjlf	189	29	or	or	CC
cord-022313-2675sjlf	189	30	more	more	JJR
cord-022313-2675sjlf	189	31	glucose	glucose	NN
cord-022313-2675sjlf	189	32	residues	residue	NNS
cord-022313-2675sjlf	189	33	.	.	.
cord-022313-2675sjlf	190	1	As	as	IN
cord-022313-2675sjlf	190	2	shown	show	VBN
cord-022313-2675sjlf	190	3	in	in	IN
cord-022313-2675sjlf	190	4	Fig	Fig	NNP
cord-022313-2675sjlf	190	5	.	.	.
cord-022313-2675sjlf	191	1	3	3	LS
cord-022313-2675sjlf	191	2	,	,	,
cord-022313-2675sjlf	191	3	following	follow	VBG
cord-022313-2675sjlf	191	4	the	the	DT
cord-022313-2675sjlf	191	5	trimming	trimming	NN
cord-022313-2675sjlf	191	6	of	of	IN
cord-022313-2675sjlf	191	7	all	all	DT
cord-022313-2675sjlf	191	8	of	of	IN
cord-022313-2675sjlf	191	9	the	the	DT
cord-022313-2675sjlf	191	10	glucose	glucose	NN
cord-022313-2675sjlf	191	11	residues	residue	NNS
cord-022313-2675sjlf	191	12	and	and	CC
cord-022313-2675sjlf	191	13	a	a	DT
cord-022313-2675sjlf	191	14	number	number	NN
cord-022313-2675sjlf	191	15	of	of	IN
cord-022313-2675sjlf	191	16	mannose	mannose	JJ
cord-022313-2675sjlf	191	17	units	unit	NNS
cord-022313-2675sjlf	191	18	from	from	IN
cord-022313-2675sjlf	191	19	the	the	DT
cord-022313-2675sjlf	191	20	N	N	NNP
cord-022313-2675sjlf	191	21	-	-	HYPH
cord-022313-2675sjlf	191	22	linked	link	VBN
cord-022313-2675sjlf	191	23	oligosaccha	oligosaccha	NN
cord-022313-2675sjlf	191	24	rides	ride	NNS
cord-022313-2675sjlf	191	25	,	,	,
cord-022313-2675sjlf	191	26	various	various	JJ
cord-022313-2675sjlf	191	27	glycosyltransferases	glycosyltransferase	NNS
cord-022313-2675sjlf	191	28	act	act	NNP
cord-022313-2675sjlf	191	29	to	to	TO
cord-022313-2675sjlf	191	30	add	add	VB
cord-022313-2675sjlf	191	31	different	different	JJ
cord-022313-2675sjlf	191	32	sugars	sugar	NNS
cord-022313-2675sjlf	191	33	,	,	,
cord-022313-2675sjlf	191	34	such	such	JJ
cord-022313-2675sjlf	191	35	as	as	IN
cord-022313-2675sjlf	191	36	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	191	37	,	,	,
cord-022313-2675sjlf	191	38	galactose	galactose	NN
cord-022313-2675sjlf	191	39	,	,	,
cord-022313-2675sjlf	191	40	sialic	sialic	NN
cord-022313-2675sjlf	191	41	acid	acid	NN
cord-022313-2675sjlf	191	42	,	,	,
cord-022313-2675sjlf	191	43	fucose	fucose	NNP
cord-022313-2675sjlf	191	44	,	,	,
cord-022313-2675sjlf	191	45	etc	etc	FW
cord-022313-2675sjlf	191	46	.	.	FW
cord-022313-2675sjlf	191	47	,	,	,
cord-022313-2675sjlf	191	48	to	to	IN
cord-022313-2675sjlf	191	49	the	the	DT
cord-022313-2675sjlf	191	50	core	core	NN
cord-022313-2675sjlf	191	51	N	N	NNP
cord-022313-2675sjlf	191	52	-	-	HYPH
cord-022313-2675sjlf	191	53	linked	link	VBN
cord-022313-2675sjlf	191	54	struc	struc	NNP
cord-022313-2675sjlf	191	55	ture	ture	NN
cord-022313-2675sjlf	191	56	to	to	TO
cord-022313-2675sjlf	191	57	form	form	VB
cord-022313-2675sjlf	191	58	many	many	JJ
cord-022313-2675sjlf	191	59	different	different	JJ
cord-022313-2675sjlf	191	60	types	type	NNS
cord-022313-2675sjlf	191	61	of	of	IN
cord-022313-2675sjlf	191	62	complex	complex	JJ
cord-022313-2675sjlf	191	63	chains	chain	NNS
cord-022313-2675sjlf	191	64	(	(	-LRB-
cord-022313-2675sjlf	191	65	95	95	CD
cord-022313-2675sjlf	191	66	)	)	-RRB-
cord-022313-2675sjlf	191	67	.	.	.
cord-022313-2675sjlf	192	1	Since	since	IN
cord-022313-2675sjlf	192	2	there	there	EX
cord-022313-2675sjlf	192	3	are	be	VBP
cord-022313-2675sjlf	192	4	no	no	DT
cord-022313-2675sjlf	192	5	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	192	6	available	available	JJ
cord-022313-2675sjlf	192	7	for	for	IN
cord-022313-2675sjlf	192	8	these	these	DT
cord-022313-2675sjlf	192	9	glycosyltransferases	glycosyltransferase	NNS
cord-022313-2675sjlf	192	10	,	,	,
cord-022313-2675sjlf	192	11	they	-PRON-	PRP
cord-022313-2675sjlf	192	12	will	will	MD
cord-022313-2675sjlf	192	13	not	not	RB
cord-022313-2675sjlf	192	14	be	be	VB
cord-022313-2675sjlf	192	15	considered	consider	VBN
cord-022313-2675sjlf	192	16	further	far	RBR
cord-022313-2675sjlf	192	17	in	in	IN
cord-022313-2675sjlf	192	18	this	this	DT
cord-022313-2675sjlf	192	19	review	review	NN
cord-022313-2675sjlf	192	20	.	.	.
cord-022313-2675sjlf	193	1	Glycosyl	Glycosyl	NNP
cord-022313-2675sjlf	193	2	phosphatidylinositols	phosphatidylinositol	NNS
cord-022313-2675sjlf	193	3	are	be	VBP
cord-022313-2675sjlf	193	4	a	a	DT
cord-022313-2675sjlf	193	5	recently	recently	RB
cord-022313-2675sjlf	193	6	discovered	discover	VBN
cord-022313-2675sjlf	193	7	class	class	NN
cord-022313-2675sjlf	193	8	of	of	IN
cord-022313-2675sjlf	193	9	glycolipids	glycolipid	NNS
cord-022313-2675sjlf	193	10	that	that	WDT
cord-022313-2675sjlf	193	11	have	have	VBP
cord-022313-2675sjlf	193	12	been	be	VBN
cord-022313-2675sjlf	193	13	shown	show	VBN
cord-022313-2675sjlf	193	14	to	to	TO
cord-022313-2675sjlf	193	15	anchor	anchor	VB
cord-022313-2675sjlf	193	16	many	many	JJ
cord-022313-2675sjlf	193	17	proteins	protein	NNS
cord-022313-2675sjlf	193	18	(	(	-LRB-
cord-022313-2675sjlf	193	19	and	and	CC
cord-022313-2675sjlf	193	20	other	other	JJ
cord-022313-2675sjlf	193	21	mole	mole	NN
cord-022313-2675sjlf	193	22	cules	cule	NNS
cord-022313-2675sjlf	193	23	such	such	JJ
cord-022313-2675sjlf	193	24	as	as	IN
cord-022313-2675sjlf	193	25	heparan	heparan	JJ
cord-022313-2675sjlf	193	26	sulfates	sulfate	NNS
cord-022313-2675sjlf	193	27	)	)	-RRB-
cord-022313-2675sjlf	193	28	to	to	IN
cord-022313-2675sjlf	193	29	biological	biological	JJ
cord-022313-2675sjlf	193	30	membranes	membrane	NNS
cord-022313-2675sjlf	193	31	via	via	IN
cord-022313-2675sjlf	193	32	covalent	covalent	JJ
cord-022313-2675sjlf	193	33	linkages	linkage	NNS
cord-022313-2675sjlf	193	34	.	.	.
cord-022313-2675sjlf	194	1	Recently	recently	RB
cord-022313-2675sjlf	194	2	,	,	,
cord-022313-2675sjlf	194	3	the	the	DT
cord-022313-2675sjlf	194	4	chemical	chemical	JJ
cord-022313-2675sjlf	194	5	nature	nature	NN
cord-022313-2675sjlf	194	6	of	of	IN
cord-022313-2675sjlf	194	7	these	these	DT
cord-022313-2675sjlf	194	8	molecules	molecule	NNS
cord-022313-2675sjlf	194	9	has	have	VBZ
cord-022313-2675sjlf	194	10	been	be	VBN
cord-022313-2675sjlf	194	11	deduced	deduce	VBN
cord-022313-2675sjlf	194	12	,	,	,
cord-022313-2675sjlf	194	13	but	but	CC
cord-022313-2675sjlf	194	14	the	the	DT
cord-022313-2675sjlf	194	15	complete	complete	JJ
cord-022313-2675sjlf	194	16	structure	structure	NN
cord-022313-2675sjlf	194	17	is	be	VBZ
cord-022313-2675sjlf	194	18	still	still	RB
cord-022313-2675sjlf	194	19	elucidated	elucidate	VBN
cord-022313-2675sjlf	194	20	only	only	RB
cord-022313-2675sjlf	194	21	for	for	IN
cord-022313-2675sjlf	194	22	a	a	DT
cord-022313-2675sjlf	194	23	few	few	JJ
cord-022313-2675sjlf	194	24	of	of	IN
cord-022313-2675sjlf	194	25	these	these	DT
cord-022313-2675sjlf	194	26	anchors	anchor	NNS
cord-022313-2675sjlf	194	27	.	.	.
cord-022313-2675sjlf	195	1	The	the	DT
cord-022313-2675sjlf	195	2	characterization	characterization	NN
cord-022313-2675sjlf	195	3	of	of	IN
cord-022313-2675sjlf	195	4	these	these	DT
cord-022313-2675sjlf	195	5	glycolipids	glycolipid	NNS
cord-022313-2675sjlf	195	6	has	have	VBZ
cord-022313-2675sjlf	195	7	involved	involve	VBN
cord-022313-2675sjlf	195	8	compositional	compositional	JJ
cord-022313-2675sjlf	195	9	analyses	analysis	NNS
cord-022313-2675sjlf	195	10	using	use	VBG
cord-022313-2675sjlf	195	11	GC	GC	NNP
cord-022313-2675sjlf	195	12	-	-	HYPH
cord-022313-2675sjlf	195	13	MS	MS	NNP
cord-022313-2675sjlf	195	14	in	in	IN
cord-022313-2675sjlf	195	15	combination	combination	NN
cord-022313-2675sjlf	195	16	with	with	IN
cord-022313-2675sjlf	195	17	specific	specific	JJ
cord-022313-2675sjlf	195	18	chemical	chemical	NN
cord-022313-2675sjlf	195	19	treatments	treatment	NNS
cord-022313-2675sjlf	195	20	and	and	CC
cord-022313-2675sjlf	195	21	sequential	sequential	JJ
cord-022313-2675sjlf	195	22	digestion	digestion	NN
cord-022313-2675sjlf	195	23	with	with	IN
cord-022313-2675sjlf	195	24	exoglycosidases	exoglycosidase	NNS
cord-022313-2675sjlf	195	25	,	,	,
cord-022313-2675sjlf	195	26	analysis	analysis	NN
cord-022313-2675sjlf	195	27	of	of	IN
cord-022313-2675sjlf	195	28	glycosidic	glycosidic	JJ
cord-022313-2675sjlf	195	29	linkages	linkage	NNS
cord-022313-2675sjlf	195	30	by	by	IN
cord-022313-2675sjlf	195	31	methylation	methylation	NN
cord-022313-2675sjlf	195	32	analyses	analysis	NNS
cord-022313-2675sjlf	195	33	,	,	,
cord-022313-2675sjlf	195	34	and	and	CC
cord-022313-2675sjlf	195	35	gel	gel	NN
cord-022313-2675sjlf	195	36	filtra	filtra	NNP
cord-022313-2675sjlf	195	37	tion	tion	NN
cord-022313-2675sjlf	195	38	and	and	CC
cord-022313-2675sjlf	195	39	TLC	TLC	NNP
cord-022313-2675sjlf	195	40	of	of	IN
cord-022313-2675sjlf	195	41	intact	intact	JJ
cord-022313-2675sjlf	195	42	glycans	glycan	NNS
cord-022313-2675sjlf	195	43	and	and	CC
cord-022313-2675sjlf	195	44	their	-PRON-	PRP$
cord-022313-2675sjlf	195	45	degradation	degradation	NN
cord-022313-2675sjlf	195	46	products	product	NNS
cord-022313-2675sjlf	195	47	(	(	-LRB-
cord-022313-2675sjlf	195	48	96	96	CD
cord-022313-2675sjlf	195	49	)	)	-RRB-
cord-022313-2675sjlf	195	50	.	.	.
cord-022313-2675sjlf	196	1	The	the	DT
cord-022313-2675sjlf	196	2	best	well	RBS
cord-022313-2675sjlf	196	3	known	know	VBN
cord-022313-2675sjlf	196	4	and	and	CC
cord-022313-2675sjlf	196	5	most	most	RBS
cord-022313-2675sjlf	196	6	thoroughly	thoroughly	RB
cord-022313-2675sjlf	196	7	detailed	detail	VBN
cord-022313-2675sjlf	196	8	GPI	GPI	NNP
cord-022313-2675sjlf	196	9	anchors	anchor	NNS
cord-022313-2675sjlf	196	10	are	be	VBP
cord-022313-2675sjlf	196	11	those	those	DT
cord-022313-2675sjlf	196	12	of	of	IN
cord-022313-2675sjlf	196	13	Trypanosoma	Trypanosoma	NNP
cord-022313-2675sjlf	196	14	brucei	brucei	NNP
cord-022313-2675sjlf	196	15	and	and	CC
cord-022313-2675sjlf	196	16	rat	rat	NN
cord-022313-2675sjlf	196	17	Thy-1	Thy-1	NNP
cord-022313-2675sjlf	196	18	.	.	.
cord-022313-2675sjlf	197	1	Although	although	IN
cord-022313-2675sjlf	197	2	these	these	DT
cord-022313-2675sjlf	197	3	structures	structure	NNS
cord-022313-2675sjlf	197	4	show	show	VBP
cord-022313-2675sjlf	197	5	some	some	DT
cord-022313-2675sjlf	197	6	differences	difference	NNS
cord-022313-2675sjlf	197	7	,	,	,
cord-022313-2675sjlf	197	8	they	-PRON-	PRP
cord-022313-2675sjlf	197	9	do	do	VBP
cord-022313-2675sjlf	197	10	have	have	VB
cord-022313-2675sjlf	197	11	a	a	DT
cord-022313-2675sjlf	197	12	conserved	conserved	JJ
cord-022313-2675sjlf	197	13	linear	linear	JJ
cord-022313-2675sjlf	197	14	region	region	NN
cord-022313-2675sjlf	197	15	shown	show	VBN
cord-022313-2675sjlf	197	16	in	in	IN
cord-022313-2675sjlf	197	17	4	4	CD
cord-022313-2675sjlf	197	18	.	.	.
cord-022313-2675sjlf	198	1	General	general	JJ
cord-022313-2675sjlf	198	2	structure	structure	NN
cord-022313-2675sjlf	198	3	of	of	IN
cord-022313-2675sjlf	198	4	the	the	DT
cord-022313-2675sjlf	198	5	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NN
cord-022313-2675sjlf	198	6	that	that	WDT
cord-022313-2675sjlf	198	7	serves	serve	VBZ
cord-022313-2675sjlf	198	8	as	as	IN
cord-022313-2675sjlf	198	9	a	a	DT
cord-022313-2675sjlf	198	10	mem	mem	NNP
cord-022313-2675sjlf	198	11	brane	brane	NN
cord-022313-2675sjlf	198	12	anchor	anchor	NN
cord-022313-2675sjlf	198	13	for	for	IN
cord-022313-2675sjlf	198	14	many	many	JJ
cord-022313-2675sjlf	198	15	cell	cell	NN
cord-022313-2675sjlf	198	16	surface	surface	NN
cord-022313-2675sjlf	198	17	proteins	protein	NNS
cord-022313-2675sjlf	198	18	.	.	.
cord-022313-2675sjlf	199	1	Fig	Fig	NNP
cord-022313-2675sjlf	199	2	.	.	.
cord-022313-2675sjlf	200	1	4	4	LS
cord-022313-2675sjlf	200	2	to	to	TO
cord-022313-2675sjlf	200	3	be	be	VB
cord-022313-2675sjlf	200	4	composed	compose	VBN
cord-022313-2675sjlf	200	5	of	of	IN
cord-022313-2675sjlf	200	6	6	6	CD
cord-022313-2675sjlf	200	7	-	-	HYPH
cord-022313-2675sjlf	200	8	0-ethanolamine	0-ethanolamine	CD
cord-022313-2675sjlf	200	9	-	-	HYPH
cord-022313-2675sjlf	200	10	P-6-Manal,2Mana	p-6-manal,2mana	NN
cord-022313-2675sjlf	200	11	:	:	:
cord-022313-2675sjlf	200	12	l	l	NN
cord-022313-2675sjlf	200	13	,	,	,
cord-022313-2675sjlf	200	14	6Manal,4GlcNal,6-inositol	6Manal,4GlcNal,6-inositol	NNP
cord-022313-2675sjlf	200	15	(	(	-LRB-
cord-022313-2675sjlf	200	16	97	97	CD
cord-022313-2675sjlf	200	17	)	)	-RRB-
cord-022313-2675sjlf	200	18	.	.	.
cord-022313-2675sjlf	201	1	In	in	IN
cord-022313-2675sjlf	201	2	the	the	DT
cord-022313-2675sjlf	201	3	case	case	NN
cord-022313-2675sjlf	201	4	of	of	IN
cord-022313-2675sjlf	201	5	the	the	DT
cord-022313-2675sjlf	201	6	variable	variable	JJ
cord-022313-2675sjlf	201	7	surface	surface	NN
cord-022313-2675sjlf	201	8	antigen	antigen	NN
cord-022313-2675sjlf	201	9	(	(	-LRB-
cord-022313-2675sjlf	201	10	i.e.	i.e.	FW
cord-022313-2675sjlf	201	11	,	,	,
cord-022313-2675sjlf	201	12	VSG	VSG	NNP
cord-022313-2675sjlf	201	13	)	)	-RRB-
cord-022313-2675sjlf	201	14	of	of	IN
cord-022313-2675sjlf	201	15	trypanosomes	trypanosome	NNS
cord-022313-2675sjlf	201	16	,	,	,
cord-022313-2675sjlf	201	17	there	there	EX
cord-022313-2675sjlf	201	18	are	be	VBP
cord-022313-2675sjlf	201	19	a	a	DT
cord-022313-2675sjlf	201	20	number	number	NN
cord-022313-2675sjlf	201	21	of	of	IN
cord-022313-2675sjlf	201	22	galactose	galactose	NN
cord-022313-2675sjlf	201	23	residues	residue	NNS
cord-022313-2675sjlf	201	24	attached	attach	VBN
cord-022313-2675sjlf	201	25	to	to	IN
cord-022313-2675sjlf	201	26	the	the	DT
cord-022313-2675sjlf	201	27	first	first	JJ
cord-022313-2675sjlf	201	28	mannose	mannose	NN
cord-022313-2675sjlf	201	29	,	,	,
cord-022313-2675sjlf	201	30	whereas	whereas	IN
cord-022313-2675sjlf	201	31	in	in	IN
cord-022313-2675sjlf	201	32	Thy-1	Thy-1	NNP
cord-022313-2675sjlf	201	33	there	there	EX
cord-022313-2675sjlf	201	34	may	may	MD
cord-022313-2675sjlf	201	35	be	be	VB
cord-022313-2675sjlf	201	36	a	a	DT
cord-022313-2675sjlf	201	37	GalNAc	galnac	NN
cord-022313-2675sjlf	201	38	and/or	and/or	CC
cord-022313-2675sjlf	201	39	an	an	DT
cord-022313-2675sjlf	201	40	ethanolamine	ethanolamine	NN
cord-022313-2675sjlf	201	41	-	-	HYPH
cord-022313-2675sjlf	201	42	P	p	NN
cord-022313-2675sjlf	201	43	attached	attach	VBN
cord-022313-2675sjlf	201	44	to	to	IN
cord-022313-2675sjlf	201	45	this	this	DT
cord-022313-2675sjlf	201	46	mannose	mannose	NN
cord-022313-2675sjlf	201	47	(	(	-LRB-
cord-022313-2675sjlf	201	48	98	98	CD
cord-022313-2675sjlf	201	49	)	)	-RRB-
cord-022313-2675sjlf	201	50	.	.	.
cord-022313-2675sjlf	202	1	Also	also	RB
cord-022313-2675sjlf	202	2	these	these	DT
cord-022313-2675sjlf	202	3	structures	structure	NNS
cord-022313-2675sjlf	202	4	may	may	MD
cord-022313-2675sjlf	202	5	differ	differ	VB
cord-022313-2675sjlf	202	6	in	in	IN
cord-022313-2675sjlf	202	7	the	the	DT
cord-022313-2675sjlf	202	8	number	number	NN
cord-022313-2675sjlf	202	9	of	of	IN
cord-022313-2675sjlf	202	10	fatty	fatty	JJ
cord-022313-2675sjlf	202	11	acid	acid	NN
cord-022313-2675sjlf	202	12	resi	resi	JJ
cord-022313-2675sjlf	202	13	dues	due	NNS
cord-022313-2675sjlf	202	14	attached	attach	VBN
cord-022313-2675sjlf	202	15	to	to	IN
cord-022313-2675sjlf	202	16	the	the	DT
cord-022313-2675sjlf	202	17	inositol	inositol	NN
cord-022313-2675sjlf	202	18	and	and	CC
cord-022313-2675sjlf	202	19	also	also	RB
cord-022313-2675sjlf	202	20	in	in	IN
cord-022313-2675sjlf	202	21	the	the	DT
cord-022313-2675sjlf	202	22	structure	structure	NN
cord-022313-2675sjlf	202	23	of	of	IN
cord-022313-2675sjlf	202	24	the	the	DT
cord-022313-2675sjlf	202	25	fatty	fatty	JJ
cord-022313-2675sjlf	202	26	acids	acid	NNS
cord-022313-2675sjlf	202	27	.	.	.
cord-022313-2675sjlf	203	1	Although	although	IN
cord-022313-2675sjlf	203	2	some	some	DT
cord-022313-2675sjlf	203	3	of	of	IN
cord-022313-2675sjlf	203	4	the	the	DT
cord-022313-2675sjlf	203	5	details	detail	NNS
cord-022313-2675sjlf	203	6	of	of	IN
cord-022313-2675sjlf	203	7	the	the	DT
cord-022313-2675sjlf	203	8	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	203	9	of	of	IN
cord-022313-2675sjlf	203	10	the	the	DT
cord-022313-2675sjlf	203	11	glycan	glycan	NN
cord-022313-2675sjlf	203	12	portion	portion	NN
cord-022313-2675sjlf	203	13	of	of	IN
cord-022313-2675sjlf	203	14	these	these	DT
cord-022313-2675sjlf	203	15	anchors	anchor	NNS
cord-022313-2675sjlf	203	16	are	be	VBP
cord-022313-2675sjlf	203	17	known	know	VBN
cord-022313-2675sjlf	203	18	,	,	,
cord-022313-2675sjlf	203	19	there	there	EX
cord-022313-2675sjlf	203	20	are	be	VBP
cord-022313-2675sjlf	203	21	still	still	RB
cord-022313-2675sjlf	203	22	considerable	considerable	JJ
cord-022313-2675sjlf	203	23	gaps	gap	NNS
cord-022313-2675sjlf	203	24	in	in	IN
cord-022313-2675sjlf	203	25	our	-PRON-	PRP$
cord-022313-2675sjlf	203	26	understanding	understanding	NN
cord-022313-2675sjlf	203	27	of	of	IN
cord-022313-2675sjlf	203	28	the	the	DT
cord-022313-2675sjlf	203	29	pathway	pathway	NN
cord-022313-2675sjlf	203	30	.	.	.
cord-022313-2675sjlf	204	1	Nevertheless	nevertheless	RB
cord-022313-2675sjlf	204	2	,	,	,
cord-022313-2675sjlf	204	3	the	the	DT
cord-022313-2675sjlf	204	4	steps	step	NNS
cord-022313-2675sjlf	204	5	in	in	IN
cord-022313-2675sjlf	204	6	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	204	7	are	be	VBP
cord-022313-2675sjlf	204	8	proposed	propose	VBN
cord-022313-2675sjlf	204	9	to	to	TO
cord-022313-2675sjlf	204	10	occur	occur	VB
cord-022313-2675sjlf	204	11	as	as	IN
cord-022313-2675sjlf	204	12	outlined	outline	VBN
cord-022313-2675sjlf	204	13	in	in	IN
cord-022313-2675sjlf	204	14	Fig	Fig	NNP
cord-022313-2675sjlf	204	15	.	.	.
cord-022313-2675sjlf	205	1	5	5	LS
cord-022313-2675sjlf	205	2	.	.	.
cord-022313-2675sjlf	206	1	The	the	DT
cord-022313-2675sjlf	206	2	sequence	sequence	NN
cord-022313-2675sjlf	206	3	begins	begin	VBZ
cord-022313-2675sjlf	206	4	with	with	IN
cord-022313-2675sjlf	206	5	the	the	DT
cord-022313-2675sjlf	206	6	transfer	transfer	NN
cord-022313-2675sjlf	206	7	of	of	IN
cord-022313-2675sjlf	206	8	a	a	DT
cord-022313-2675sjlf	206	9	GlcNAc	glcnac	NN
cord-022313-2675sjlf	206	10	from	from	IN
cord-022313-2675sjlf	206	11	UDP	UDP	NNP
cord-022313-2675sjlf	206	12	-	-	HYPH
cord-022313-2675sjlf	206	13	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	206	14	to	to	TO
cord-022313-2675sjlf	206	15	phosphatidylinositol	phosphatidylinositol	NN
cord-022313-2675sjlf	206	16	to	to	TO
cord-022313-2675sjlf	206	17	form	form	VB
cord-022313-2675sjlf	206	18	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	206	19	-	-	HYPH
cord-022313-2675sjlf	206	20	PI	PI	NNP
cord-022313-2675sjlf	206	21	,	,	,
cord-022313-2675sjlf	206	22	which	which	WDT
cord-022313-2675sjlf	206	23	then	then	RB
cord-022313-2675sjlf	206	24	undergoes	undergo	VBZ
cord-022313-2675sjlf	206	25	deacetylation	deacetylation	NN
cord-022313-2675sjlf	206	26	to	to	TO
cord-022313-2675sjlf	206	27	form	form	VB
cord-022313-2675sjlf	206	28	GlcN	GlcN	NNP
cord-022313-2675sjlf	206	29	-	-	HYPH
cord-022313-2675sjlf	206	30	PI	PI	NNP
cord-022313-2675sjlf	206	31	(	(	-LRB-
cord-022313-2675sjlf	206	32	99	99	CD
cord-022313-2675sjlf	206	33	)	)	-RRB-
cord-022313-2675sjlf	206	34	.	.	.
cord-022313-2675sjlf	207	1	These	these	DT
cord-022313-2675sjlf	207	2	reactions	reaction	NNS
cord-022313-2675sjlf	207	3	have	have	VBP
cord-022313-2675sjlf	207	4	been	be	VBN
cord-022313-2675sjlf	207	5	demonstrated	demonstrate	VBN
cord-022313-2675sjlf	207	6	in	in	IN
cord-022313-2675sjlf	207	7	vivo	vivo	NN
cord-022313-2675sjlf	207	8	by	by	IN
cord-022313-2675sjlf	207	9	labeling	label	VBG
cord-022313-2675sjlf	207	10	studies	study	NNS
cord-022313-2675sjlf	207	11	with	with	IN
cord-022313-2675sjlf	207	12	3	3	CD
cord-022313-2675sjlf	207	13	H	h	NN
cord-022313-2675sjlf	207	14	-	-	HYPH
cord-022313-2675sjlf	207	15	glucosamine	glucosamine	NN
cord-022313-2675sjlf	207	16	and	and	CC
cord-022313-2675sjlf	207	17	in	in	IN
cord-022313-2675sjlf	207	18	cell	cell	NN
cord-022313-2675sjlf	207	19	-	-	HYPH
cord-022313-2675sjlf	207	20	free	free	JJ
cord-022313-2675sjlf	207	21	extracts	extract	NNS
cord-022313-2675sjlf	207	22	incubated	incubate	VBN
cord-022313-2675sjlf	207	23	with	with	IN
cord-022313-2675sjlf	207	24	UDP	UDP	NNP
cord-022313-2675sjlf	207	25	-	-	HYPH
cord-022313-2675sjlf	207	26	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	207	27	.	.	.
cord-022313-2675sjlf	208	1	Three	three	CD
cord-022313-2675sjlf	208	2	mannose	mannose	NN
cord-022313-2675sjlf	208	3	residues	residue	NNS
cord-022313-2675sjlf	208	4	are	be	VBP
cord-022313-2675sjlf	208	5	then	then	RB
cord-022313-2675sjlf	208	6	added	add	VBN
cord-022313-2675sjlf	208	7	to	to	IN
cord-022313-2675sjlf	208	8	the	the	DT
cord-022313-2675sjlf	208	9	GlcN	GlcN	NNP
cord-022313-2675sjlf	208	10	-	-	HYPH
cord-022313-2675sjlf	208	11	PI	PI	NNP
cord-022313-2675sjlf	208	12	and	and	CC
cord-022313-2675sjlf	208	13	these	these	DT
cord-022313-2675sjlf	208	14	mannoses	mannose	NNS
cord-022313-2675sjlf	208	15	are	be	VBP
cord-022313-2675sjlf	208	16	all	all	DT
cord-022313-2675sjlf	208	17	proposed	propose	VBN
cord-022313-2675sjlf	208	18	to	to	TO
cord-022313-2675sjlf	208	19	be	be	VB
cord-022313-2675sjlf	208	20	derived	derive	VBN
cord-022313-2675sjlf	208	21	from	from	IN
cord-022313-2675sjlf	208	22	dolichyl	dolichyl	NN
cord-022313-2675sjlf	208	23	-	-	HYPH
cord-022313-2675sjlf	208	24	P	p	NN
cord-022313-2675sjlf	208	25	-	-	HYPH
cord-022313-2675sjlf	208	26	mannose	mannose	NN
cord-022313-2675sjlf	208	27	,	,	,
cord-022313-2675sjlf	208	28	rather	rather	RB
cord-022313-2675sjlf	208	29	than	than	IN
cord-022313-2675sjlf	208	30	from	from	IN
cord-022313-2675sjlf	208	31	GDP	gdp	NN
cord-022313-2675sjlf	208	32	-	-	HYPH
cord-022313-2675sjlf	208	33	mannose	mannose	NN
cord-022313-2675sjlf	208	34	(	(	-LRB-
cord-022313-2675sjlf	208	35	see	see	VB
cord-022313-2675sjlf	208	36	Section	Section	NNP
cord-022313-2675sjlf	208	37	IX	IX	NNP
cord-022313-2675sjlf	208	38	for	for	IN
cord-022313-2675sjlf	208	39	experimental	experimental	JJ
cord-022313-2675sjlf	208	40	evidence	evidence	NN
cord-022313-2675sjlf	208	41	)	)	-RRB-
cord-022313-2675sjlf	208	42	.	.	.
cord-022313-2675sjlf	209	1	None	none	NN
cord-022313-2675sjlf	209	2	of	of	IN
cord-022313-2675sjlf	209	3	these	these	DT
cord-022313-2675sjlf	209	4	enzymes	enzyme	NNS
cord-022313-2675sjlf	209	5	has	have	VBZ
cord-022313-2675sjlf	209	6	been	be	VBN
cord-022313-2675sjlf	209	7	purified	purify	VBN
cord-022313-2675sjlf	209	8	and	and	CC
cord-022313-2675sjlf	209	9	virtually	virtually	RB
cord-022313-2675sjlf	209	10	nothing	nothing	NN
cord-022313-2675sjlf	209	11	is	be	VBZ
cord-022313-2675sjlf	209	12	known	know	VBN
cord-022313-2675sjlf	209	13	about	about	IN
cord-022313-2675sjlf	209	14	how	how	WRB
cord-022313-2675sjlf	209	15	other	other	JJ
cord-022313-2675sjlf	209	16	sugars	sugar	NNS
cord-022313-2675sjlf	209	17	such	such	JJ
cord-022313-2675sjlf	209	18	as	as	IN
cord-022313-2675sjlf	209	19	Gal	Gal	NNP
cord-022313-2675sjlf	209	20	or	or	CC
cord-022313-2675sjlf	209	21	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	209	22	are	be	VBP
cord-022313-2675sjlf	209	23	added	add	VBN
cord-022313-2675sjlf	209	24	.	.	.
cord-022313-2675sjlf	210	1	In	in	IN
cord-022313-2675sjlf	210	2	addition	addition	NN
cord-022313-2675sjlf	210	3	,	,	,
cord-022313-2675sjlf	210	4	it	-PRON-	PRP
cord-022313-2675sjlf	210	5	is	be	VBZ
cord-022313-2675sjlf	210	6	not	not	RB
cord-022313-2675sjlf	210	7	clear	clear	JJ
cord-022313-2675sjlf	210	8	when	when	WRB
cord-022313-2675sjlf	210	9	in	in	IN
cord-022313-2675sjlf	210	10	the	the	DT
cord-022313-2675sjlf	210	11	biosynthetic	biosynthetic	JJ
cord-022313-2675sjlf	210	12	pathway	pathway	NN
cord-022313-2675sjlf	210	13	the	the	DT
cord-022313-2675sjlf	210	14	fatty	fatty	JJ
cord-022313-2675sjlf	210	15	acids	acid	NNS
cord-022313-2675sjlf	210	16	are	be	VBP
cord-022313-2675sjlf	210	17	added	add	VBN
cord-022313-2675sjlf	210	18	to	to	IN
cord-022313-2675sjlf	210	19	the	the	DT
cord-022313-2675sjlf	210	20	PI	PI	NNP
cord-022313-2675sjlf	210	21	,	,	,
cord-022313-2675sjlf	210	22	although	although	IN
cord-022313-2675sjlf	210	23	there	there	EX
cord-022313-2675sjlf	210	24	is	be	VBZ
cord-022313-2675sjlf	210	25	now	now	RB
cord-022313-2675sjlf	210	26	evidence	evidence	NN
cord-022313-2675sjlf	210	27	that	that	IN
cord-022313-2675sjlf	210	28	the	the	DT
cord-022313-2675sjlf	210	29	GlcN	GlcN	NNP
cord-022313-2675sjlf	210	30	-	-	HYPH
cord-022313-2675sjlf	210	31	PI	PI	NNP
cord-022313-2675sjlf	210	32	must	must	MD
cord-022313-2675sjlf	210	33	be	be	VB
cord-022313-2675sjlf	210	34	acylated	acylate	VBN
cord-022313-2675sjlf	210	35	to	to	TO
cord-022313-2675sjlf	210	36	serve	serve	VB
cord-022313-2675sjlf	210	37	as	as	IN
cord-022313-2675sjlf	210	38	an	an	DT
cord-022313-2675sjlf	210	39	acceptor	acceptor	NN
cord-022313-2675sjlf	210	40	for	for	IN
cord-022313-2675sjlf	210	41	the	the	DT
cord-022313-2675sjlf	210	42	first	first	JJ
cord-022313-2675sjlf	210	43	mannose	mannose	NN
cord-022313-2675sjlf	210	44	(	(	-LRB-
cord-022313-2675sjlf	210	45	100	100	CD
cord-022313-2675sjlf	210	46	)	)	-RRB-
cord-022313-2675sjlf	210	47	.	.	.
cord-022313-2675sjlf	211	1	Once	once	IN
cord-022313-2675sjlf	211	2	the	the	DT
cord-022313-2675sjlf	211	3	mannose	mannose	NN
cord-022313-2675sjlf	211	4	units	unit	NNS
cord-022313-2675sjlf	211	5	have	have	VBP
cord-022313-2675sjlf	211	6	been	be	VBN
cord-022313-2675sjlf	211	7	added	add	VBN
cord-022313-2675sjlf	211	8	,	,	,
cord-022313-2675sjlf	211	9	phosphatidylethanolamine	phosphatidylethanolamine	NNP
cord-022313-2675sjlf	211	10	serves	serve	VBZ
cord-022313-2675sjlf	211	11	as	as	IN
cord-022313-2675sjlf	211	12	a	a	DT
cord-022313-2675sjlf	211	13	donor	donor	NN
cord-022313-2675sjlf	211	14	of	of	IN
cord-022313-2675sjlf	211	15	ethanolamine	ethanolamine	NN
cord-022313-2675sjlf	211	16	-	-	HYPH
cord-022313-2675sjlf	211	17	P	p	NN
cord-022313-2675sjlf	211	18	,	,	,
cord-022313-2675sjlf	211	19	which	which	WDT
cord-022313-2675sjlf	211	20	becomes	become	VBZ
cord-022313-2675sjlf	211	21	attached	attach	VBN
cord-022313-2675sjlf	211	22	via	via	IN
cord-022313-2675sjlf	211	23	a	a	DT
cord-022313-2675sjlf	211	24	phosphodiester	phosphodiester	NN
cord-022313-2675sjlf	211	25	bond	bond	NN
cord-022313-2675sjlf	211	26	to	to	IN
cord-022313-2675sjlf	211	27	the	the	DT
cord-022313-2675sjlf	211	28	6	6	CD
cord-022313-2675sjlf	211	29	position	position	NN
cord-022313-2675sjlf	211	30	of	of	IN
cord-022313-2675sjlf	211	31	the	the	DT
cord-022313-2675sjlf	211	32	terminal	terminal	JJ
cord-022313-2675sjlf	211	33	mannose	mannose	NN
cord-022313-2675sjlf	211	34	.	.	.
cord-022313-2675sjlf	212	1	The	the	DT
cord-022313-2675sjlf	212	2	signal	signal	NN
cord-022313-2675sjlf	212	3	for	for	IN
cord-022313-2675sjlf	212	4	GPI	GPI	NNP
cord-022313-2675sjlf	212	5	addition	addition	NN
cord-022313-2675sjlf	212	6	to	to	IN
cord-022313-2675sjlf	212	7	the	the	DT
cord-022313-2675sjlf	212	8	nascent	nascent	JJ
cord-022313-2675sjlf	212	9	protein	protein	NN
cord-022313-2675sjlf	212	10	resides	reside	VBZ
cord-022313-2675sjlf	212	11	in	in	IN
cord-022313-2675sjlf	212	12	a	a	DT
cord-022313-2675sjlf	212	13	short	short	JJ
cord-022313-2675sjlf	212	14	hydrophobic	hydrophobic	JJ
cord-022313-2675sjlf	212	15	carboxy	carboxy	JJ
cord-022313-2675sjlf	212	16	-	-	HYPH
cord-022313-2675sjlf	212	17	terminal	terminal	NN
cord-022313-2675sjlf	212	18	peptide	peptide	NN
cord-022313-2675sjlf	212	19	that	that	WDT
cord-022313-2675sjlf	212	20	is	be	VBZ
cord-022313-2675sjlf	212	21	removed	remove	VBN
cord-022313-2675sjlf	212	22	and	and	CC
cord-022313-2675sjlf	212	23	replaced	replace	VBN
cord-022313-2675sjlf	212	24	by	by	IN
cord-022313-2675sjlf	212	25	the	the	DT
cord-022313-2675sjlf	212	26	GPI	GPI	NNP
cord-022313-2675sjlf	212	27	anchor	anchor	NN
cord-022313-2675sjlf	212	28	(	(	-LRB-
cord-022313-2675sjlf	212	29	101	101	CD
cord-022313-2675sjlf	212	30	)	)	-RRB-
cord-022313-2675sjlf	212	31	.	.	.
cord-022313-2675sjlf	213	1	This	this	DT
cord-022313-2675sjlf	213	2	addition	addition	NN
cord-022313-2675sjlf	213	3	of	of	IN
cord-022313-2675sjlf	213	4	protein	protein	NN
cord-022313-2675sjlf	213	5	to	to	IN
cord-022313-2675sjlf	213	6	the	the	DT
cord-022313-2675sjlf	213	7	GPI	GPI	NNP
cord-022313-2675sjlf	213	8	apparantly	apparantly	RB
cord-022313-2675sjlf	213	9	occurs	occur	VBZ
cord-022313-2675sjlf	213	10	on	on	IN
cord-022313-2675sjlf	213	11	internal	internal	JJ
cord-022313-2675sjlf	213	12	membranes	membrane	NNS
cord-022313-2675sjlf	213	13	,	,	,
cord-022313-2675sjlf	213	14	but	but	CC
cord-022313-2675sjlf	213	15	the	the	DT
cord-022313-2675sjlf	213	16	details	detail	NNS
cord-022313-2675sjlf	213	17	of	of	IN
cord-022313-2675sjlf	213	18	these	these	DT
cord-022313-2675sjlf	213	19	biosynthetic	biosynthetic	JJ
cord-022313-2675sjlf	213	20	steps	step	NNS
cord-022313-2675sjlf	213	21	are	be	VBP
cord-022313-2675sjlf	213	22	not	not	RB
cord-022313-2675sjlf	213	23	known	know	VBN
cord-022313-2675sjlf	213	24	at	at	IN
cord-022313-2675sjlf	213	25	this	this	DT
cord-022313-2675sjlf	213	26	time	time	NN
cord-022313-2675sjlf	213	27	.	.	.
cord-022313-2675sjlf	214	1	Probably	probably	RB
cord-022313-2675sjlf	214	2	the	the	DT
cord-022313-2675sjlf	214	3	most	most	RBS
cord-022313-2675sjlf	214	4	widely	widely	RB
cord-022313-2675sjlf	214	5	used	use	VBN
cord-022313-2675sjlf	214	6	and	and	CC
cord-022313-2675sjlf	214	7	most	most	RBS
cord-022313-2675sjlf	214	8	valuable	valuable	JJ
cord-022313-2675sjlf	214	9	inhibitor	inhibitor	NN
cord-022313-2675sjlf	214	10	of	of	IN
cord-022313-2675sjlf	214	11	Nlinked	Nlinked	NNP
cord-022313-2675sjlf	214	12	glycosylation	glycosylation	NN
cord-022313-2675sjlf	214	13	is	be	VBZ
cord-022313-2675sjlf	214	14	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	214	15	.	.	.
cord-022313-2675sjlf	215	1	This	this	DT
cord-022313-2675sjlf	215	2	compound	compound	NN
cord-022313-2675sjlf	215	3	is	be	VBZ
cord-022313-2675sjlf	215	4	a	a	DT
cord-022313-2675sjlf	215	5	nucleoside	nucleoside	NN
cord-022313-2675sjlf	215	6	antibiotic	antibiotic	NN
cord-022313-2675sjlf	215	7	that	that	WDT
cord-022313-2675sjlf	215	8	is	be	VBZ
cord-022313-2675sjlf	215	9	produced	produce	VBN
cord-022313-2675sjlf	215	10	by	by	IN
cord-022313-2675sjlf	215	11	the	the	DT
cord-022313-2675sjlf	215	12	bacterium	bacterium	NN
cord-022313-2675sjlf	215	13	Streptomyces	Streptomyces	NNP
cord-022313-2675sjlf	215	14	lysosuperificus	lysosuperificus	NNP
cord-022313-2675sjlf	215	15	and	and	CC
cord-022313-2675sjlf	215	16	was	be	VBD
cord-022313-2675sjlf	215	17	initially	initially	RB
cord-022313-2675sjlf	215	18	found	find	VBN
cord-022313-2675sjlf	215	19	to	to	TO
cord-022313-2675sjlf	215	20	inhibit	inhibit	VB
cord-022313-2675sjlf	215	21	the	the	DT
cord-022313-2675sjlf	215	22	replication	replication	NN
cord-022313-2675sjlf	215	23	of	of	IN
cord-022313-2675sjlf	215	24	a	a	DT
cord-022313-2675sjlf	215	25	number	number	NN
cord-022313-2675sjlf	215	26	of	of	IN
cord-022313-2675sjlf	215	27	enveloped	envelop	VBN
cord-022313-2675sjlf	215	28	viruses	virus	NNS
cord-022313-2675sjlf	215	29	(	(	-LRB-
cord-022313-2675sjlf	215	30	102	102	CD
cord-022313-2675sjlf	215	31	)	)	-RRB-
cord-022313-2675sjlf	215	32	.	.	.
cord-022313-2675sjlf	216	1	The	the	DT
cord-022313-2675sjlf	216	2	structure	structure	NN
cord-022313-2675sjlf	216	3	of	of	IN
cord-022313-2675sjlf	216	4	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	216	5	was	be	VBD
cord-022313-2675sjlf	216	6	elegantly	elegantly	RB
cord-022313-2675sjlf	216	7	elucidated	elucidate	VBN
cord-022313-2675sjlf	216	8	by	by	IN
cord-022313-2675sjlf	216	9	Tamura	Tamura	NNP
cord-022313-2675sjlf	216	10	and	and	CC
cord-022313-2675sjlf	216	11	co	co	NNS
cord-022313-2675sjlf	216	12	-	-	NNS
cord-022313-2675sjlf	216	13	workers	worker	NNS
cord-022313-2675sjlf	216	14	(	(	-LRB-
cord-022313-2675sjlf	216	15	103	103	CD
cord-022313-2675sjlf	216	16	)	)	-RRB-
cord-022313-2675sjlf	216	17	and	and	CC
cord-022313-2675sjlf	216	18	is	be	VBZ
cord-022313-2675sjlf	216	19	shown	show	VBN
cord-022313-2675sjlf	216	20	in	in	IN
cord-022313-2675sjlf	216	21	Fig	Fig	NNP
cord-022313-2675sjlf	216	22	.	.	.
cord-022313-2675sjlf	217	1	6	6	LS
cord-022313-2675sjlf	217	2	.	.	.
cord-022313-2675sjlf	218	1	The	the	DT
cord-022313-2675sjlf	218	2	antibiotic	antibiotic	NN
cord-022313-2675sjlf	218	3	contains	contain	VBZ
cord-022313-2675sjlf	218	4	a	a	DT
cord-022313-2675sjlf	218	5	uracil	uracil	NN
cord-022313-2675sjlf	218	6	moiety	moiety	NN
cord-022313-2675sjlf	218	7	to	to	TO
cord-022313-2675sjlf	218	8	which	which	WDT
cord-022313-2675sjlf	218	9	is	be	VBZ
cord-022313-2675sjlf	218	10	attached	attach	VBN
cord-022313-2675sjlf	218	11	,	,	,
cord-022313-2675sjlf	218	12	by	by	IN
cord-022313-2675sjlf	218	13	an	an	DT
cord-022313-2675sjlf	218	14	Nglycosidic	Nglycosidic	NNP
cord-022313-2675sjlf	218	15	bond	bond	NN
cord-022313-2675sjlf	218	16	,	,	,
cord-022313-2675sjlf	218	17	an	an	DT
cord-022313-2675sjlf	218	18	11	11	CD
cord-022313-2675sjlf	218	19	carbon	carbon	NN
cord-022313-2675sjlf	218	20	aminodeoxydialdose	aminodeoxydialdose	NN
cord-022313-2675sjlf	218	21	called	call	VBN
cord-022313-2675sjlf	218	22	tunicamine	tunicamine	NNP
cord-022313-2675sjlf	218	23	.	.	.
cord-022313-2675sjlf	219	1	The	the	DT
cord-022313-2675sjlf	219	2	tunicamine	tunicamine	NN
cord-022313-2675sjlf	219	3	is	be	VBZ
cord-022313-2675sjlf	219	4	itself	-PRON-	PRP
cord-022313-2675sjlf	219	5	substituted	substitute	VBN
cord-022313-2675sjlf	219	6	by	by	IN
cord-022313-2675sjlf	219	7	having	have	VBG
cord-022313-2675sjlf	219	8	a	a	DT
cord-022313-2675sjlf	219	9	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	219	10	attached	attach	VBN
cord-022313-2675sjlf	219	11	to	to	IN
cord-022313-2675sjlf	219	12	6	6	CD
cord-022313-2675sjlf	219	13	.	.	.
cord-022313-2675sjlf	220	1	The	the	DT
cord-022313-2675sjlf	220	2	structure(s	structure(s	NN
cord-022313-2675sjlf	220	3	)	)	-RRB-
cord-022313-2675sjlf	220	4	of	of	IN
cord-022313-2675sjlf	220	5	the	the	DT
cord-022313-2675sjlf	220	6	various	various	JJ
cord-022313-2675sjlf	220	7	tunicamycin	tunicamycin	NN
cord-022313-2675sjlf	220	8	components	component	NNS
cord-022313-2675sjlf	220	9	.	.	.
cord-022313-2675sjlf	221	1	R	r	NN
cord-022313-2675sjlf	221	2	refers	refer	VBZ
cord-022313-2675sjlf	221	3	to	to	IN
cord-022313-2675sjlf	221	4	the	the	DT
cord-022313-2675sjlf	221	5	differ	differ	NNS
cord-022313-2675sjlf	221	6	ent	ent	NNP
cord-022313-2675sjlf	221	7	fatty	fatty	JJ
cord-022313-2675sjlf	221	8	acids	acid	NNS
cord-022313-2675sjlf	221	9	,	,	,
cord-022313-2675sjlf	221	10	designated	designate	VBN
cord-022313-2675sjlf	221	11	I	-PRON-	PRP
cord-022313-2675sjlf	221	12	to	to	IN
cord-022313-2675sjlf	221	13	X	x	NN
cord-022313-2675sjlf	221	14	,	,	,
cord-022313-2675sjlf	221	15	that	that	WDT
cord-022313-2675sjlf	221	16	may	may	MD
cord-022313-2675sjlf	221	17	be	be	VB
cord-022313-2675sjlf	221	18	attached	attach	VBN
cord-022313-2675sjlf	221	19	to	to	IN
cord-022313-2675sjlf	221	20	the	the	DT
cord-022313-2675sjlf	221	21	tunicamine	tunicamine	JJ
cord-022313-2675sjlf	221	22	portion	portion	NN
cord-022313-2675sjlf	221	23	of	of	IN
cord-022313-2675sjlf	221	24	the	the	DT
cord-022313-2675sjlf	221	25	molecule	molecule	NN
cord-022313-2675sjlf	221	26	.	.	.
cord-022313-2675sjlf	222	1	its	-PRON-	PRP$
cord-022313-2675sjlf	222	2	anomeric	anomeric	NN
cord-022313-2675sjlf	222	3	carbon	carbon	NN
cord-022313-2675sjlf	222	4	in	in	IN
cord-022313-2675sjlf	222	5	an	an	DT
cord-022313-2675sjlf	222	6	O	o	NN
cord-022313-2675sjlf	222	7	-	-	HYPH
cord-022313-2675sjlf	222	8	glycosidic	glycosidic	JJ
cord-022313-2675sjlf	222	9	bond	bond	NN
cord-022313-2675sjlf	222	10	and	and	CC
cord-022313-2675sjlf	222	11	a	a	DT
cord-022313-2675sjlf	222	12	fatty	fatty	JJ
cord-022313-2675sjlf	222	13	acid	acid	NN
cord-022313-2675sjlf	222	14	linked	link	VBN
cord-022313-2675sjlf	222	15	in	in	IN
cord-022313-2675sjlf	222	16	amide	amide	NN
cord-022313-2675sjlf	222	17	bond	bond	NN
cord-022313-2675sjlf	222	18	to	to	IN
cord-022313-2675sjlf	222	19	the	the	DT
cord-022313-2675sjlf	222	20	amino	amino	NN
cord-022313-2675sjlf	222	21	group	group	NN
cord-022313-2675sjlf	222	22	.	.	.
cord-022313-2675sjlf	223	1	The	the	DT
cord-022313-2675sjlf	223	2	fatty	fatty	JJ
cord-022313-2675sjlf	223	3	acid	acid	NN
cord-022313-2675sjlf	223	4	may	may	MD
cord-022313-2675sjlf	223	5	vary	vary	VB
cord-022313-2675sjlf	223	6	in	in	IN
cord-022313-2675sjlf	223	7	structure	structure	NN
cord-022313-2675sjlf	223	8	from	from	IN
cord-022313-2675sjlf	223	9	C	C	NNP
cord-022313-2675sjlf	223	10	12	12	CD
cord-022313-2675sjlf	223	11	to	to	IN
cord-022313-2675sjlf	223	12	C	C	NNP
cord-022313-2675sjlf	223	13	16	16	CD
cord-022313-2675sjlf	223	14	,	,	,
cord-022313-2675sjlf	223	15	may	may	MD
cord-022313-2675sjlf	223	16	be	be	VB
cord-022313-2675sjlf	223	17	saturated	saturate	VBN
cord-022313-2675sjlf	223	18	or	or	CC
cord-022313-2675sjlf	223	19	unsaturated	unsaturated	JJ
cord-022313-2675sjlf	223	20	,	,	,
cord-022313-2675sjlf	223	21	and	and	CC
cord-022313-2675sjlf	223	22	may	may	MD
cord-022313-2675sjlf	223	23	be	be	VB
cord-022313-2675sjlf	223	24	branched	branch	VBN
cord-022313-2675sjlf	223	25	or	or	CC
cord-022313-2675sjlf	223	26	unbranched	unbranched	JJ
cord-022313-2675sjlf	223	27	.	.	.
cord-022313-2675sjlf	224	1	In	in	IN
cord-022313-2675sjlf	224	2	fact	fact	NN
cord-022313-2675sjlf	224	3	,	,	,
cord-022313-2675sjlf	224	4	tunicamycin	tunicamycin	NNP
cord-022313-2675sjlf	224	5	is	be	VBZ
cord-022313-2675sjlf	224	6	actually	actually	RB
cord-022313-2675sjlf	224	7	produced	produce	VBN
cord-022313-2675sjlf	224	8	as	as	IN
cord-022313-2675sjlf	224	9	a	a	DT
cord-022313-2675sjlf	224	10	complex	complex	NN
cord-022313-2675sjlf	224	11	that	that	WDT
cord-022313-2675sjlf	224	12	can	can	MD
cord-022313-2675sjlf	224	13	be	be	VB
cord-022313-2675sjlf	224	14	separated	separate	VBN
cord-022313-2675sjlf	224	15	into	into	IN
cord-022313-2675sjlf	224	16	as	as	RB
cord-022313-2675sjlf	224	17	many	many	JJ
cord-022313-2675sjlf	224	18	as	as	IN
cord-022313-2675sjlf	224	19	10	10	CD
cord-022313-2675sjlf	224	20	to	to	TO
cord-022313-2675sjlf	224	21	15	15	CD
cord-022313-2675sjlf	224	22	peaks	peak	NNS
cord-022313-2675sjlf	224	23	by	by	IN
cord-022313-2675sjlf	224	24	HPLC	HPLC	NNP
cord-022313-2675sjlf	224	25	(	(	-LRB-
cord-022313-2675sjlf	224	26	22	22	CD
cord-022313-2675sjlf	224	27	,	,	,
cord-022313-2675sjlf	224	28	104	104	CD
cord-022313-2675sjlf	224	29	)	)	-RRB-
cord-022313-2675sjlf	224	30	,	,	,
cord-022313-2675sjlf	224	31	and	and	CC
cord-022313-2675sjlf	224	32	the	the	DT
cord-022313-2675sjlf	224	33	basis	basis	NN
cord-022313-2675sjlf	224	34	of	of	IN
cord-022313-2675sjlf	224	35	this	this	DT
cord-022313-2675sjlf	224	36	separation	separation	NN
cord-022313-2675sjlf	224	37	is	be	VBZ
cord-022313-2675sjlf	224	38	the	the	DT
cord-022313-2675sjlf	224	39	fatty	fatty	JJ
cord-022313-2675sjlf	224	40	acid	acid	NN
cord-022313-2675sjlf	224	41	moiety	moiety	NN
cord-022313-2675sjlf	224	42	.	.	.
cord-022313-2675sjlf	225	1	Interestingly	interestingly	RB
cord-022313-2675sjlf	225	2	enough	enough	RB
cord-022313-2675sjlf	225	3	,	,	,
cord-022313-2675sjlf	225	4	all	all	DT
cord-022313-2675sjlf	225	5	of	of	IN
cord-022313-2675sjlf	225	6	these	these	DT
cord-022313-2675sjlf	225	7	peaks	peak	NNS
cord-022313-2675sjlf	225	8	have	have	VBP
cord-022313-2675sjlf	225	9	biological	biological	JJ
cord-022313-2675sjlf	225	10	activity	activity	NN
cord-022313-2675sjlf	225	11	,	,	,
cord-022313-2675sjlf	225	12	but	but	CC
cord-022313-2675sjlf	225	13	those	those	DT
cord-022313-2675sjlf	225	14	compo	compo	NN
cord-022313-2675sjlf	225	15	nents	nent	NNS
cord-022313-2675sjlf	225	16	with	with	IN
cord-022313-2675sjlf	225	17	the	the	DT
cord-022313-2675sjlf	225	18	longer	long	JJR
cord-022313-2675sjlf	225	19	chain	chain	NN
cord-022313-2675sjlf	225	20	fatty	fatty	JJ
cord-022313-2675sjlf	225	21	acids	acid	NNS
cord-022313-2675sjlf	225	22	appear	appear	VBP
cord-022313-2675sjlf	225	23	to	to	TO
cord-022313-2675sjlf	225	24	be	be	VB
cord-022313-2675sjlf	225	25	more	more	RBR
cord-022313-2675sjlf	225	26	effective	effective	JJ
cord-022313-2675sjlf	225	27	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	225	28	in	in	IN
cord-022313-2675sjlf	225	29	cell	cell	NN
cord-022313-2675sjlf	225	30	culture	culture	NN
cord-022313-2675sjlf	225	31	(	(	-LRB-
cord-022313-2675sjlf	225	32	22	22	CD
cord-022313-2675sjlf	225	33	)	)	-RRB-
cord-022313-2675sjlf	225	34	,	,	,
cord-022313-2675sjlf	225	35	possibly	possibly	RB
cord-022313-2675sjlf	225	36	because	because	IN
cord-022313-2675sjlf	225	37	they	-PRON-	PRP
cord-022313-2675sjlf	225	38	are	be	VBP
cord-022313-2675sjlf	225	39	taken	take	VBN
cord-022313-2675sjlf	225	40	up	up	RP
cord-022313-2675sjlf	225	41	by	by	IN
cord-022313-2675sjlf	225	42	the	the	DT
cord-022313-2675sjlf	225	43	cells	cell	NNS
cord-022313-2675sjlf	225	44	at	at	IN
cord-022313-2675sjlf	225	45	a	a	DT
cord-022313-2675sjlf	225	46	faster	fast	JJR
cord-022313-2675sjlf	225	47	rate	rate	NN
cord-022313-2675sjlf	225	48	.	.	.
cord-022313-2675sjlf	226	1	The	the	DT
cord-022313-2675sjlf	226	2	site	site	NN
cord-022313-2675sjlf	226	3	of	of	IN
cord-022313-2675sjlf	226	4	action	action	NN
cord-022313-2675sjlf	226	5	of	of	IN
cord-022313-2675sjlf	226	6	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	226	7	was	be	VBD
cord-022313-2675sjlf	226	8	initially	initially	RB
cord-022313-2675sjlf	226	9	demonstrated	demonstrate	VBN
cord-022313-2675sjlf	226	10	with	with	IN
cord-022313-2675sjlf	226	11	a	a	DT
cord-022313-2675sjlf	226	12	microsomal	microsomal	FW
cord-022313-2675sjlf	226	13	enzyme	enzyme	NN
cord-022313-2675sjlf	226	14	preparation	preparation	NN
cord-022313-2675sjlf	226	15	from	from	IN
cord-022313-2675sjlf	226	16	calf	calf	NN
cord-022313-2675sjlf	226	17	liver	liver	NN
cord-022313-2675sjlf	226	18	,	,	,
cord-022313-2675sjlf	226	19	and	and	CC
cord-022313-2675sjlf	226	20	the	the	DT
cord-022313-2675sjlf	226	21	antibiotic	antibiotic	NN
cord-022313-2675sjlf	226	22	was	be	VBD
cord-022313-2675sjlf	226	23	shown	show	VBN
cord-022313-2675sjlf	226	24	to	to	TO
cord-022313-2675sjlf	226	25	be	be	VB
cord-022313-2675sjlf	226	26	a	a	DT
cord-022313-2675sjlf	226	27	potent	potent	JJ
cord-022313-2675sjlf	226	28	inhibitor	inhibitor	NN
cord-022313-2675sjlf	226	29	of	of	IN
cord-022313-2675sjlf	226	30	the	the	DT
cord-022313-2675sjlf	226	31	enzyme	enzyme	NN
cord-022313-2675sjlf	226	32	that	that	WDT
cord-022313-2675sjlf	226	33	transfers	transfer	VBZ
cord-022313-2675sjlf	226	34	GlcNAc-1-P	glcnac-1-p	VBP
cord-022313-2675sjlf	226	35	from	from	IN
cord-022313-2675sjlf	226	36	UDP	UDP	NNP
cord-022313-2675sjlf	226	37	-	-	HYPH
cord-022313-2675sjlf	226	38	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	226	39	to	to	IN
cord-022313-2675sjlf	226	40	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	226	41	-	-	HYPH
cord-022313-2675sjlf	226	42	P	p	NN
cord-022313-2675sjlf	226	43	(	(	-LRB-
cord-022313-2675sjlf	226	44	32	32	CD
cord-022313-2675sjlf	226	45	,	,	,
cord-022313-2675sjlf	226	46	105	105	CD
cord-022313-2675sjlf	226	47	)	)	-RRB-
cord-022313-2675sjlf	226	48	.	.	.
cord-022313-2675sjlf	227	1	This	this	DT
cord-022313-2675sjlf	227	2	reaction	reaction	NN
cord-022313-2675sjlf	227	3	produces	produce	VBZ
cord-022313-2675sjlf	227	4	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	227	5	-	-	HYPH
cord-022313-2675sjlf	227	6	PP	PP	NNP
cord-022313-2675sjlf	227	7	-	-	HYPH
cord-022313-2675sjlf	227	8	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	227	9	,	,	,
cord-022313-2675sjlf	227	10	which	which	WDT
cord-022313-2675sjlf	227	11	is	be	VBZ
cord-022313-2675sjlf	227	12	the	the	DT
cord-022313-2675sjlf	227	13	first	first	JJ
cord-022313-2675sjlf	227	14	intermediate	intermediate	JJ
cord-022313-2675sjlf	227	15	in	in	IN
cord-022313-2675sjlf	227	16	the	the	DT
cord-022313-2675sjlf	227	17	dolichol	dolichol	NNP
cord-022313-2675sjlf	227	18	pathway	pathway	NN
cord-022313-2675sjlf	227	19	.	.	.
cord-022313-2675sjlf	228	1	Tunicamycin	Tunicamycin	NNP
cord-022313-2675sjlf	228	2	had	have	VBD
cord-022313-2675sjlf	228	3	the	the	DT
cord-022313-2675sjlf	228	4	same	same	JJ
cord-022313-2675sjlf	228	5	site	site	NN
cord-022313-2675sjlf	228	6	of	of	IN
cord-022313-2675sjlf	228	7	action	action	NN
cord-022313-2675sjlf	228	8	in	in	IN
cord-022313-2675sjlf	228	9	plant	plant	NN
cord-022313-2675sjlf	228	10	microsomes	microsome	NNS
cord-022313-2675sjlf	228	11	(	(	-LRB-
cord-022313-2675sjlf	228	12	106	106	CD
cord-022313-2675sjlf	228	13	)	)	-RRB-
cord-022313-2675sjlf	228	14	and	and	CC
cord-022313-2675sjlf	228	15	in	in	IN
cord-022313-2675sjlf	228	16	microsomes	microsome	NNS
cord-022313-2675sjlf	228	17	from	from	IN
cord-022313-2675sjlf	228	18	chick	chick	NNP
cord-022313-2675sjlf	228	19	oviduct	oviduct	NN
cord-022313-2675sjlf	228	20	(	(	-LRB-
cord-022313-2675sjlf	228	21	107	107	CD
cord-022313-2675sjlf	228	22	)	)	-RRB-
cord-022313-2675sjlf	228	23	.	.	.
cord-022313-2675sjlf	229	1	In	in	IN
cord-022313-2675sjlf	229	2	addition	addition	NN
cord-022313-2675sjlf	229	3	,	,	,
cord-022313-2675sjlf	229	4	tuni	tuni	NNP
cord-022313-2675sjlf	229	5	camycin	camycin	NNS
cord-022313-2675sjlf	229	6	is	be	VBZ
cord-022313-2675sjlf	229	7	a	a	DT
cord-022313-2675sjlf	229	8	very	very	RB
cord-022313-2675sjlf	229	9	potent	potent	JJ
cord-022313-2675sjlf	229	10	inhibitor	inhibitor	NN
cord-022313-2675sjlf	229	11	with	with	IN
cord-022313-2675sjlf	229	12	partially	partially	RB
cord-022313-2675sjlf	229	13	purified	purify	VBN
cord-022313-2675sjlf	229	14	preparations	preparation	NNS
cord-022313-2675sjlf	229	15	of	of	IN
cord-022313-2675sjlf	229	16	the	the	DT
cord-022313-2675sjlf	229	17	UDP	UDP	NNP
cord-022313-2675sjlf	229	18	-	-	HYPH
cord-022313-2675sjlf	229	19	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	229	20	:	:	:
cord-022313-2675sjlf	229	21	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	229	22	-	-	HYPH
cord-022313-2675sjlf	229	23	P	P	NNP
cord-022313-2675sjlf	229	24	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	229	25	-	-	HYPH
cord-022313-2675sjlf	229	26	l	l	NN
cord-022313-2675sjlf	229	27	-	-	HYPH
cord-022313-2675sjlf	229	28	P	p	NN
cord-022313-2675sjlf	229	29	transferase	transferase	NN
cord-022313-2675sjlf	229	30	from	from	IN
cord-022313-2675sjlf	229	31	several	several	JJ
cord-022313-2675sjlf	229	32	animal	animal	NN
cord-022313-2675sjlf	229	33	tissues	tissue	NNS
cord-022313-2675sjlf	229	34	(	(	-LRB-
cord-022313-2675sjlf	229	35	22	22	CD
cord-022313-2675sjlf	229	36	,	,	,
cord-022313-2675sjlf	229	37	32	32	CD
cord-022313-2675sjlf	229	38	,	,	,
cord-022313-2675sjlf	229	39	108	108	CD
cord-022313-2675sjlf	229	40	)	)	-RRB-
cord-022313-2675sjlf	229	41	.	.	.
cord-022313-2675sjlf	230	1	This	this	DT
cord-022313-2675sjlf	230	2	inhibitor	inhibitor	NN
cord-022313-2675sjlf	230	3	also	also	RB
cord-022313-2675sjlf	230	4	affects	affect	VBZ
cord-022313-2675sjlf	230	5	several	several	JJ
cord-022313-2675sjlf	230	6	microbial	microbial	JJ
cord-022313-2675sjlf	230	7	enzymes	enzyme	NNS
cord-022313-2675sjlf	230	8	that	that	WDT
cord-022313-2675sjlf	230	9	are	be	VBP
cord-022313-2675sjlf	230	10	involved	involve	VBN
cord-022313-2675sjlf	230	11	in	in	IN
cord-022313-2675sjlf	230	12	the	the	DT
cord-022313-2675sjlf	230	13	synthesis	synthesis	NN
cord-022313-2675sjlf	230	14	of	of	IN
cord-022313-2675sjlf	230	15	peptidoglycan	peptidoglycan	NN
cord-022313-2675sjlf	230	16	,	,	,
cord-022313-2675sjlf	230	17	i.e.	i.e.	FW
cord-022313-2675sjlf	230	18	,	,	,
cord-022313-2675sjlf	230	19	the	the	DT
cord-022313-2675sjlf	230	20	enzyme	enzyme	NN
cord-022313-2675sjlf	230	21	that	that	WDT
cord-022313-2675sjlf	230	22	forms	form	VBZ
cord-022313-2675sjlf	230	23	undecaprenyl	undecaprenyl	NN
cord-022313-2675sjlf	230	24	-	-	HYPH
cord-022313-2675sjlf	230	25	PP	PP	NNP
cord-022313-2675sjlf	230	26	-	-	HYPH
cord-022313-2675sjlf	230	27	iV	iV	NNP
cord-022313-2675sjlf	230	28	-	-	HYPH
cord-022313-2675sjlf	230	29	acetylmuramoyl	acetylmuramoyl	NNP
cord-022313-2675sjlf	230	30	-	-	HYPH
cord-022313-2675sjlf	230	31	pentapeptide	pentapeptide	NNP
cord-022313-2675sjlf	230	32	(	(	-LRB-
cord-022313-2675sjlf	230	33	109	109	CD
cord-022313-2675sjlf	230	34	)	)	-RRB-
cord-022313-2675sjlf	230	35	,	,	,
cord-022313-2675sjlf	230	36	and	and	CC
cord-022313-2675sjlf	230	37	the	the	DT
cord-022313-2675sjlf	230	38	enzyme	enzyme	NN
cord-022313-2675sjlf	230	39	involved	involve	VBN
cord-022313-2675sjlf	230	40	in	in	IN
cord-022313-2675sjlf	230	41	production	production	NN
cord-022313-2675sjlf	230	42	of	of	IN
cord-022313-2675sjlf	230	43	undecaprenyl	undecaprenyl	NN
cord-022313-2675sjlf	230	44	-	-	HYPH
cord-022313-2675sjlf	230	45	PP	PP	NNP
cord-022313-2675sjlf	230	46	-	-	HYPH
cord-022313-2675sjlf	230	47	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	230	48	(	(	-LRB-
cord-022313-2675sjlf	230	49	110	110	CD
cord-022313-2675sjlf	230	50	)	)	-RRB-
cord-022313-2675sjlf	230	51	.	.	.
cord-022313-2675sjlf	231	1	However	however	RB
cord-022313-2675sjlf	231	2	,	,	,
cord-022313-2675sjlf	231	3	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	231	4	had	have	VBD
cord-022313-2675sjlf	231	5	no	no	DT
cord-022313-2675sjlf	231	6	effect	effect	NN
cord-022313-2675sjlf	231	7	on	on	IN
cord-022313-2675sjlf	231	8	other	other	JJ
cord-022313-2675sjlf	231	9	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	231	10	transferases	transferase	NNS
cord-022313-2675sjlf	231	11	such	such	JJ
cord-022313-2675sjlf	231	12	as	as	IN
cord-022313-2675sjlf	231	13	the	the	DT
cord-022313-2675sjlf	231	14	enzyme	enzyme	NN
cord-022313-2675sjlf	231	15	that	that	WDT
cord-022313-2675sjlf	231	16	adds	add	VBZ
cord-022313-2675sjlf	231	17	the	the	DT
cord-022313-2675sjlf	231	18	next	next	JJ
cord-022313-2675sjlf	231	19	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	231	20	to	to	IN
cord-022313-2675sjlf	231	21	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	231	22	-	-	HYPH
cord-022313-2675sjlf	231	23	PP	PP	NNP
cord-022313-2675sjlf	231	24	-	-	HYPH
cord-022313-2675sjlf	231	25	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	231	26	(	(	-LRB-
cord-022313-2675sjlf	231	27	111	111	CD
cord-022313-2675sjlf	231	28	)	)	-RRB-
cord-022313-2675sjlf	231	29	,	,	,
cord-022313-2675sjlf	231	30	the	the	DT
cord-022313-2675sjlf	231	31	enzymes	enzyme	NNS
cord-022313-2675sjlf	231	32	that	that	WDT
cord-022313-2675sjlf	231	33	add	add	VBP
cord-022313-2675sjlf	231	34	terminal	terminal	JJ
cord-022313-2675sjlf	231	35	GlcNAc	glcnac	NN
cord-022313-2675sjlf	231	36	residues	residue	NNS
cord-022313-2675sjlf	231	37	to	to	IN
cord-022313-2675sjlf	231	38	the	the	DT
cord-022313-2675sjlf	231	39	N	n	NN
cord-022313-2675sjlf	231	40	-	-	HYPH
cord-022313-2675sjlf	231	41	linked	link	VBN
cord-022313-2675sjlf	231	42	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	231	43	core	core	NN
cord-022313-2675sjlf	231	44	(	(	-LRB-
cord-022313-2675sjlf	231	45	107	107	CD
cord-022313-2675sjlf	231	46	)	)	-RRB-
cord-022313-2675sjlf	231	47	,	,	,
cord-022313-2675sjlf	231	48	the	the	DT
cord-022313-2675sjlf	231	49	phosphotransferase	phosphotransferase	NN
cord-022313-2675sjlf	231	50	that	that	WDT
cord-022313-2675sjlf	231	51	adds	add	VBZ
cord-022313-2675sjlf	231	52	GlcNAc-1-P	glcnac-1-p	JJ
cord-022313-2675sjlf	231	53	to	to	IN
cord-022313-2675sjlf	231	54	high	high	JJ
cord-022313-2675sjlf	231	55	-	-	HYPH
cord-022313-2675sjlf	231	56	mannose	mannose	NN
cord-022313-2675sjlf	231	57	chains	chain	NNS
cord-022313-2675sjlf	231	58	on	on	IN
cord-022313-2675sjlf	231	59	lysosomal	lysosomal	JJ
cord-022313-2675sjlf	231	60	enzymes	enzyme	NNS
cord-022313-2675sjlf	231	61	(	(	-LRB-
cord-022313-2675sjlf	231	62	112	112	CD
cord-022313-2675sjlf	231	63	)	)	-RRB-
cord-022313-2675sjlf	231	64	,	,	,
cord-022313-2675sjlf	231	65	and	and	CC
cord-022313-2675sjlf	231	66	the	the	DT
cord-022313-2675sjlf	231	67	trans	trans	NNP
cord-022313-2675sjlf	231	68	ferase	ferase	NNP
cord-022313-2675sjlf	231	69	that	that	WDT
cord-022313-2675sjlf	231	70	adds	add	VBZ
cord-022313-2675sjlf	231	71	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	231	72	to	to	IN
cord-022313-2675sjlf	231	73	serine	serine	JJ
cord-022313-2675sjlf	231	74	residues	residue	NNS
cord-022313-2675sjlf	231	75	on	on	IN
cord-022313-2675sjlf	231	76	nuclear	nuclear	JJ
cord-022313-2675sjlf	231	77	proteins	protein	NNS
cord-022313-2675sjlf	231	78	(	(	-LRB-
cord-022313-2675sjlf	231	79	113	113	CD
cord-022313-2675sjlf	231	80	)	)	-RRB-
cord-022313-2675sjlf	231	81	.	.	.
cord-022313-2675sjlf	232	1	It	-PRON-	PRP
cord-022313-2675sjlf	232	2	also	also	RB
cord-022313-2675sjlf	232	3	had	have	VBD
cord-022313-2675sjlf	232	4	no	no	DT
cord-022313-2675sjlf	232	5	effect	effect	NN
cord-022313-2675sjlf	232	6	on	on	IN
cord-022313-2675sjlf	232	7	the	the	DT
cord-022313-2675sjlf	232	8	formation	formation	NN
cord-022313-2675sjlf	232	9	of	of	IN
cord-022313-2675sjlf	232	10	undecaprenyl	undecaprenyl	NN
cord-022313-2675sjlf	232	11	-	-	HYPH
cord-022313-2675sjlf	232	12	PP	pp	NN
cord-022313-2675sjlf	232	13	-	-	HYPH
cord-022313-2675sjlf	232	14	galactose	galactose	NN
cord-022313-2675sjlf	232	15	or	or	CC
cord-022313-2675sjlf	232	16	undecaprenyl	undecaprenyl	NN
cord-022313-2675sjlf	232	17	-	-	HYPH
cord-022313-2675sjlf	232	18	PP	PP	NNP
cord-022313-2675sjlf	232	19	-	-	HYPH
cord-022313-2675sjlf	232	20	GalNAc	GalNAc	NNP
cord-022313-2675sjlf	232	21	(	(	-LRB-
cord-022313-2675sjlf	232	22	114	114	CD
cord-022313-2675sjlf	232	23	)	)	-RRB-
cord-022313-2675sjlf	232	24	,	,	,
cord-022313-2675sjlf	232	25	but	but	CC
cord-022313-2675sjlf	232	26	at	at	IN
cord-022313-2675sjlf	232	27	high	high	JJ
cord-022313-2675sjlf	232	28	concentrations	concentration	NNS
cord-022313-2675sjlf	232	29	it	-PRON-	PRP
cord-022313-2675sjlf	232	30	did	do	VBD
cord-022313-2675sjlf	232	31	inhibit	inhibit	VB
cord-022313-2675sjlf	232	32	formation	formation	NN
cord-022313-2675sjlf	232	33	of	of	IN
cord-022313-2675sjlf	232	34	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	232	35	-	-	HYPH
cord-022313-2675sjlf	232	36	P	p	NN
cord-022313-2675sjlf	232	37	-	-	HYPH
cord-022313-2675sjlf	232	38	glucose	glucose	NN
cord-022313-2675sjlf	232	39	(	(	-LRB-
cord-022313-2675sjlf	232	40	115	115	CD
cord-022313-2675sjlf	232	41	)	)	-RRB-
cord-022313-2675sjlf	232	42	.	.	.
cord-022313-2675sjlf	233	1	Summing	sum	VBG
cord-022313-2675sjlf	233	2	up	up	RP
cord-022313-2675sjlf	233	3	these	these	DT
cord-022313-2675sjlf	233	4	data	datum	NNS
cord-022313-2675sjlf	233	5	,	,	,
cord-022313-2675sjlf	233	6	it	-PRON-	PRP
cord-022313-2675sjlf	233	7	appears	appear	VBZ
cord-022313-2675sjlf	233	8	that	that	IN
cord-022313-2675sjlf	233	9	tunicamycin	tunicamycin	NNP
cord-022313-2675sjlf	233	10	inhibits	inhibit	VBZ
cord-022313-2675sjlf	233	11	phosphotransferases	phosphotransferase	NNS
cord-022313-2675sjlf	233	12	that	that	WDT
cord-022313-2675sjlf	233	13	catalyze	catalyze	VBP
cord-022313-2675sjlf	233	14	the	the	DT
cord-022313-2675sjlf	233	15	translocation	translocation	NN
cord-022313-2675sjlf	233	16	of	of	IN
cord-022313-2675sjlf	233	17	a	a	DT
cord-022313-2675sjlf	233	18	GlcNAc-1-P	glcnac-1-p	NN
cord-022313-2675sjlf	233	19	from	from	IN
cord-022313-2675sjlf	233	20	its	-PRON-	PRP$
cord-022313-2675sjlf	233	21	UDP	udp	NN
cord-022313-2675sjlf	233	22	derivative	derivative	NN
cord-022313-2675sjlf	233	23	to	to	IN
cord-022313-2675sjlf	233	24	a	a	DT
cord-022313-2675sjlf	233	25	polyprenyl	polyprenyl	NN
cord-022313-2675sjlf	233	26	-	-	HYPH
cord-022313-2675sjlf	233	27	P	p	NN
cord-022313-2675sjlf	233	28	,	,	,
cord-022313-2675sjlf	233	29	but	but	CC
cord-022313-2675sjlf	233	30	the	the	DT
cord-022313-2675sjlf	233	31	sugar	sugar	NN
cord-022313-2675sjlf	233	32	must	must	MD
cord-022313-2675sjlf	233	33	be	be	VB
cord-022313-2675sjlf	233	34	chirally	chirally	RB
cord-022313-2675sjlf	233	35	related	relate	VBN
cord-022313-2675sjlf	233	36	to	to	IN
cord-022313-2675sjlf	233	37	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	233	38	.	.	.
cord-022313-2675sjlf	234	1	Tunicamycin	Tunicamycin	NNP
cord-022313-2675sjlf	234	2	is	be	VBZ
cord-022313-2675sjlf	234	3	probably	probably	RB
cord-022313-2675sjlf	234	4	a	a	DT
cord-022313-2675sjlf	234	5	competitive	competitive	JJ
cord-022313-2675sjlf	234	6	inhibitor	inhibitor	NN
cord-022313-2675sjlf	234	7	of	of	IN
cord-022313-2675sjlf	234	8	the	the	DT
cord-022313-2675sjlf	234	9	GlcNAc-1-P	glcnac-1-p	JJ
cord-022313-2675sjlf	234	10	transferase	transferase	NN
cord-022313-2675sjlf	234	11	,	,	,
cord-022313-2675sjlf	234	12	but	but	CC
cord-022313-2675sjlf	234	13	it	-PRON-	PRP
cord-022313-2675sjlf	234	14	binds	bind	VBZ
cord-022313-2675sjlf	234	15	so	so	RB
cord-022313-2675sjlf	234	16	tightly	tightly	RB
cord-022313-2675sjlf	234	17	to	to	IN
cord-022313-2675sjlf	234	18	this	this	DT
cord-022313-2675sjlf	234	19	enzyme	enzyme	NN
cord-022313-2675sjlf	234	20	that	that	IN
cord-022313-2675sjlf	234	21	it	-PRON-	PRP
cord-022313-2675sjlf	234	22	has	have	VBZ
cord-022313-2675sjlf	234	23	not	not	RB
cord-022313-2675sjlf	234	24	been	be	VBN
cord-022313-2675sjlf	234	25	possible	possible	JJ
cord-022313-2675sjlf	234	26	to	to	TO
cord-022313-2675sjlf	234	27	reverse	reverse	VB
cord-022313-2675sjlf	234	28	the	the	DT
cord-022313-2675sjlf	234	29	inhibition	inhibition	NN
cord-022313-2675sjlf	234	30	by	by	IN
cord-022313-2675sjlf	234	31	adding	add	VBG
cord-022313-2675sjlf	234	32	high	high	JJ
cord-022313-2675sjlf	234	33	concentra	concentra	NNP
cord-022313-2675sjlf	234	34	tions	tion	NNS
cord-022313-2675sjlf	234	35	of	of	IN
cord-022313-2675sjlf	234	36	UDP	UDP	NNP
cord-022313-2675sjlf	234	37	-	-	HYPH
cord-022313-2675sjlf	234	38	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	234	39	(	(	-LRB-
cord-022313-2675sjlf	234	40	105	105	CD
cord-022313-2675sjlf	234	41	)	)	-RRB-
cord-022313-2675sjlf	234	42	.	.	.
cord-022313-2675sjlf	235	1	It	-PRON-	PRP
cord-022313-2675sjlf	235	2	was	be	VBD
cord-022313-2675sjlf	235	3	suggested	suggest	VBN
cord-022313-2675sjlf	235	4	that	that	IN
cord-022313-2675sjlf	235	5	this	this	DT
cord-022313-2675sjlf	235	6	compound	compound	NN
cord-022313-2675sjlf	235	7	was	be	VBD
cord-022313-2675sjlf	235	8	a	a	DT
cord-022313-2675sjlf	235	9	tight	tight	RB
cord-022313-2675sjlf	235	10	-	-	HYPH
cord-022313-2675sjlf	235	11	binding	bind	VBG
cord-022313-2675sjlf	235	12	reversible	reversible	JJ
cord-022313-2675sjlf	235	13	inhibitor	inhibitor	NN
cord-022313-2675sjlf	235	14	and	and	CC
cord-022313-2675sjlf	235	15	might	may	MD
cord-022313-2675sjlf	235	16	be	be	VB
cord-022313-2675sjlf	235	17	a	a	DT
cord-022313-2675sjlf	235	18	substrate	substrate	NN
cord-022313-2675sjlf	235	19	-	-	HYPH
cord-022313-2675sjlf	235	20	product	product	NN
cord-022313-2675sjlf	235	21	transition	transition	NN
cord-022313-2675sjlf	235	22	-	-	HYPH
cord-022313-2675sjlf	235	23	state	state	NN
cord-022313-2675sjlf	235	24	analog	analog	NN
cord-022313-2675sjlf	235	25	(	(	-LRB-
cord-022313-2675sjlf	235	26	32	32	CD
cord-022313-2675sjlf	235	27	)	)	-RRB-
cord-022313-2675sjlf	235	28	.	.	.
cord-022313-2675sjlf	236	1	Tunicamycin	Tunicamycin	NNP
cord-022313-2675sjlf	236	2	has	have	VBZ
cord-022313-2675sjlf	236	3	been	be	VBN
cord-022313-2675sjlf	236	4	used	use	VBN
cord-022313-2675sjlf	236	5	in	in	IN
cord-022313-2675sjlf	236	6	many	many	JJ
cord-022313-2675sjlf	236	7	cell	cell	NN
cord-022313-2675sjlf	236	8	culture	culture	NN
cord-022313-2675sjlf	236	9	systems	system	NNS
cord-022313-2675sjlf	236	10	to	to	TO
cord-022313-2675sjlf	236	11	try	try	VB
cord-022313-2675sjlf	236	12	and	and	CC
cord-022313-2675sjlf	236	13	assess	assess	VB
cord-022313-2675sjlf	236	14	the	the	DT
cord-022313-2675sjlf	236	15	role	role	NN
cord-022313-2675sjlf	236	16	of	of	IN
cord-022313-2675sjlf	236	17	N	n	NN
cord-022313-2675sjlf	236	18	-	-	HYPH
cord-022313-2675sjlf	236	19	linked	link	VBN
cord-022313-2675sjlf	236	20	glycosylation	glycosylation	NN
cord-022313-2675sjlf	236	21	in	in	IN
cord-022313-2675sjlf	236	22	the	the	DT
cord-022313-2675sjlf	236	23	function	function	NN
cord-022313-2675sjlf	236	24	of	of	IN
cord-022313-2675sjlf	236	25	various	various	JJ
cord-022313-2675sjlf	236	26	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	236	27	.	.	.
cord-022313-2675sjlf	237	1	Probably	probably	RB
cord-022313-2675sjlf	237	2	the	the	DT
cord-022313-2675sjlf	237	3	best	good	JJS
cord-022313-2675sjlf	237	4	test	test	NN
cord-022313-2675sjlf	237	5	of	of	IN
cord-022313-2675sjlf	237	6	whether	whether	IN
cord-022313-2675sjlf	237	7	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	237	8	is	be	VBZ
cord-022313-2675sjlf	237	9	really	really	RB
cord-022313-2675sjlf	237	10	effective	effective	JJ
cord-022313-2675sjlf	237	11	in	in	IN
cord-022313-2675sjlf	237	12	preventing	prevent	VBG
cord-022313-2675sjlf	237	13	glycosylation	glycosylation	NN
cord-022313-2675sjlf	237	14	in	in	IN
cord-022313-2675sjlf	237	15	cell	cell	NN
cord-022313-2675sjlf	237	16	culture	culture	NN
cord-022313-2675sjlf	237	17	is	be	VBZ
cord-022313-2675sjlf	237	18	to	to	TO
cord-022313-2675sjlf	237	19	determine	determine	VB
cord-022313-2675sjlf	237	20	whether	whether	IN
cord-022313-2675sjlf	237	21	it	-PRON-	PRP
cord-022313-2675sjlf	237	22	blocks	block	VBZ
cord-022313-2675sjlf	237	23	the	the	DT
cord-022313-2675sjlf	237	24	in	in	IN
cord-022313-2675sjlf	237	25	vivo	vivo	NN
cord-022313-2675sjlf	237	26	incorporation	incorporation	NN
cord-022313-2675sjlf	237	27	of	of	IN
cord-022313-2675sjlf	237	28	labeled	label	VBN
cord-022313-2675sjlf	237	29	glucosamine	glucosamine	NN
cord-022313-2675sjlf	237	30	into	into	IN
cord-022313-2675sjlf	237	31	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	237	32	-	-	HYPH
cord-022313-2675sjlf	237	33	PP	PP	NNP
cord-022313-2675sjlf	237	34	-	-	HYPH
cord-022313-2675sjlf	237	35	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	237	36	or	or	CC
cord-022313-2675sjlf	237	37	the	the	DT
cord-022313-2675sjlf	237	38	incorporation	incorporation	NN
cord-022313-2675sjlf	237	39	of	of	IN
cord-022313-2675sjlf	237	40	[	[	-LRB-
cord-022313-2675sjlf	237	41	2	2	CD
cord-022313-2675sjlf	237	42	-	-	SYM
cord-022313-2675sjlf	237	43	3	3	CD
cord-022313-2675sjlf	237	44	H]mannose	H]mannose	NNP
cord-022313-2675sjlf	237	45	into	into	IN
cord-022313-2675sjlf	237	46	lipidlinked	lipidlinked	JJ
cord-022313-2675sjlf	237	47	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	237	48	.	.	.
cord-022313-2675sjlf	238	1	To	to	TO
cord-022313-2675sjlf	238	2	do	do	VB
cord-022313-2675sjlf	238	3	this	this	DT
cord-022313-2675sjlf	238	4	,	,	,
cord-022313-2675sjlf	238	5	one	one	PRP
cord-022313-2675sjlf	238	6	can	can	MD
cord-022313-2675sjlf	238	7	incubate	incubate	VB
cord-022313-2675sjlf	238	8	cell	cell	NN
cord-022313-2675sjlf	238	9	cultures	culture	NNS
cord-022313-2675sjlf	238	10	in	in	IN
cord-022313-2675sjlf	238	11	the	the	DT
cord-022313-2675sjlf	238	12	presence	presence	NN
cord-022313-2675sjlf	238	13	of	of	IN
cord-022313-2675sjlf	238	14	various	various	JJ
cord-022313-2675sjlf	238	15	concentrations	concentration	NNS
cord-022313-2675sjlf	238	16	of	of	IN
cord-022313-2675sjlf	238	17	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	238	18	(	(	-LRB-
cord-022313-2675sjlf	238	19	usually	usually	RB
cord-022313-2675sjlf	238	20	0.1	0.1	CD
cord-022313-2675sjlf	238	21	to	to	TO
cord-022313-2675sjlf	238	22	10	10	CD
cord-022313-2675sjlf	238	23	μg	μg	NN
cord-022313-2675sjlf	238	24	/	/	SYM
cord-022313-2675sjlf	238	25	ml	ml	NNP
cord-022313-2675sjlf	238	26	)	)	-RRB-
cord-022313-2675sjlf	238	27	for	for	IN
cord-022313-2675sjlf	238	28	30	30	CD
cord-022313-2675sjlf	238	29	min	min	NN
cord-022313-2675sjlf	238	30	to	to	IN
cord-022313-2675sjlf	238	31	1	1	CD
cord-022313-2675sjlf	238	32	hr	hr	NN
cord-022313-2675sjlf	238	33	and	and	CC
cord-022313-2675sjlf	238	34	then	then	RB
cord-022313-2675sjlf	238	35	add	add	VB
cord-022313-2675sjlf	238	36	the	the	DT
cord-022313-2675sjlf	238	37	labeled	label	VBN
cord-022313-2675sjlf	238	38	glucosamine	glucosamine	NN
cord-022313-2675sjlf	238	39	or	or	CC
cord-022313-2675sjlf	238	40	mannose	mannose	NN
cord-022313-2675sjlf	238	41	to	to	IN
cord-022313-2675sjlf	238	42	these	these	DT
cord-022313-2675sjlf	238	43	cells	cell	NNS
cord-022313-2675sjlf	238	44	.	.	.
cord-022313-2675sjlf	239	1	After	after	IN
cord-022313-2675sjlf	239	2	an	an	DT
cord-022313-2675sjlf	239	3	appropriate	appropriate	JJ
cord-022313-2675sjlf	239	4	period	period	NN
cord-022313-2675sjlf	239	5	of	of	IN
cord-022313-2675sjlf	239	6	labeling	labeling	NN
cord-022313-2675sjlf	239	7	(	(	-LRB-
cord-022313-2675sjlf	239	8	deter	deter	VB
cord-022313-2675sjlf	239	9	mined	mine	VBN
cord-022313-2675sjlf	239	10	experimentally	experimentally	RB
cord-022313-2675sjlf	239	11	for	for	IN
cord-022313-2675sjlf	239	12	each	each	DT
cord-022313-2675sjlf	239	13	cell	cell	NN
cord-022313-2675sjlf	239	14	type	type	NN
cord-022313-2675sjlf	239	15	)	)	-RRB-
cord-022313-2675sjlf	239	16	,	,	,
cord-022313-2675sjlf	239	17	the	the	DT
cord-022313-2675sjlf	239	18	cell	cell	NN
cord-022313-2675sjlf	239	19	pellet	pellet	NN
cord-022313-2675sjlf	239	20	is	be	VBZ
cord-022313-2675sjlf	239	21	extracted	extract	VBN
cord-022313-2675sjlf	239	22	with	with	IN
cord-022313-2675sjlf	239	23	CHC1	CHC1	NNP
cord-022313-2675sjlf	239	24	3	3	CD
cord-022313-2675sjlf	239	25	:	:	:
cord-022313-2675sjlf	239	26	CH	CH	NNP
cord-022313-2675sjlf	239	27	3	3	CD
cord-022313-2675sjlf	239	28	0H	0h	NN
cord-022313-2675sjlf	239	29	:	:	:
cord-022313-2675sjlf	240	1	H	h	NN
cord-022313-2675sjlf	240	2	2	2	CD
cord-022313-2675sjlf	240	3	0	0	NFP
cord-022313-2675sjlf	240	4	(	(	-LRB-
cord-022313-2675sjlf	240	5	1:1:1	1:1:1	CD
cord-022313-2675sjlf	240	6	)	)	-RRB-
cord-022313-2675sjlf	241	1	and	and	CC
cord-022313-2675sjlf	241	2	then	then	RB
cord-022313-2675sjlf	241	3	CHC1	CHC1	NNP
cord-022313-2675sjlf	241	4	3	3	CD
cord-022313-2675sjlf	241	5	:	:	:
cord-022313-2675sjlf	242	1	CH	CH	NNP
cord-022313-2675sjlf	242	2	3	3	CD
cord-022313-2675sjlf	242	3	0H	0h	NN
cord-022313-2675sjlf	242	4	:	:	:
cord-022313-2675sjlf	243	1	H	h	NN
cord-022313-2675sjlf	243	2	2	2	CD
cord-022313-2675sjlf	243	3	0	0	CD
cord-022313-2675sjlf	243	4	(	(	-LRB-
cord-022313-2675sjlf	243	5	10:10:3	10:10:3	CD
cord-022313-2675sjlf	243	6	)	)	-RRB-
cord-022313-2675sjlf	243	7	to	to	TO
cord-022313-2675sjlf	243	8	obtain	obtain	VB
cord-022313-2675sjlf	243	9	the	the	DT
cord-022313-2675sjlf	243	10	lipid	lipid	NN
cord-022313-2675sjlf	243	11	-	-	HYPH
cord-022313-2675sjlf	243	12	linked	link	VBN
cord-022313-2675sjlf	243	13	monosaccharides	monosaccharide	NNS
cord-022313-2675sjlf	243	14	and	and	CC
cord-022313-2675sjlf	243	15	the	the	DT
cord-022313-2675sjlf	243	16	lipid	lipid	NN
cord-022313-2675sjlf	243	17	-	-	HYPH
cord-022313-2675sjlf	243	18	linked	link	VBN
cord-022313-2675sjlf	243	19	oligo	oligo	NN
cord-022313-2675sjlf	243	20	saccharides	saccharide	NNS
cord-022313-2675sjlf	243	21	(	(	-LRB-
cord-022313-2675sjlf	243	22	116	116	CD
cord-022313-2675sjlf	243	23	)	)	-RRB-
cord-022313-2675sjlf	243	24	.	.	.
cord-022313-2675sjlf	244	1	One	one	CD
cord-022313-2675sjlf	244	2	important	important	JJ
cord-022313-2675sjlf	244	3	point	point	NN
cord-022313-2675sjlf	244	4	here	here	RB
cord-022313-2675sjlf	244	5	is	be	VBZ
cord-022313-2675sjlf	244	6	that	that	IN
cord-022313-2675sjlf	244	7	the	the	DT
cord-022313-2675sjlf	244	8	effective	effective	JJ
cord-022313-2675sjlf	244	9	concen	concen	NNP
cord-022313-2675sjlf	244	10	tration	tration	NNP
cord-022313-2675sjlf	244	11	of	of	IN
cord-022313-2675sjlf	244	12	inhibitor	inhibitor	NN
cord-022313-2675sjlf	244	13	may	may	MD
cord-022313-2675sjlf	244	14	vary	vary	VB
cord-022313-2675sjlf	244	15	widely	widely	RB
cord-022313-2675sjlf	244	16	depending	depend	VBG
cord-022313-2675sjlf	244	17	on	on	IN
cord-022313-2675sjlf	244	18	the	the	DT
cord-022313-2675sjlf	244	19	cell	cell	NN
cord-022313-2675sjlf	244	20	system	system	NN
cord-022313-2675sjlf	244	21	being	be	VBG
cord-022313-2675sjlf	244	22	used	use	VBN
cord-022313-2675sjlf	244	23	,	,	,
cord-022313-2675sjlf	244	24	and	and	CC
cord-022313-2675sjlf	244	25	the	the	DT
cord-022313-2675sjlf	244	26	optimum	optimum	JJ
cord-022313-2675sjlf	244	27	concentration	concentration	NN
cord-022313-2675sjlf	244	28	needs	need	VBZ
cord-022313-2675sjlf	244	29	to	to	TO
cord-022313-2675sjlf	244	30	be	be	VB
cord-022313-2675sjlf	244	31	determined	determine	VBN
cord-022313-2675sjlf	244	32	in	in	IN
cord-022313-2675sjlf	244	33	each	each	DT
cord-022313-2675sjlf	244	34	case	case	NN
cord-022313-2675sjlf	244	35	.	.	.
cord-022313-2675sjlf	245	1	In	in	IN
cord-022313-2675sjlf	245	2	fact	fact	NN
cord-022313-2675sjlf	245	3	,	,	,
cord-022313-2675sjlf	245	4	it	-PRON-	PRP
cord-022313-2675sjlf	245	5	has	have	VBZ
cord-022313-2675sjlf	245	6	been	be	VBN
cord-022313-2675sjlf	245	7	demonstrated	demonstrate	VBN
cord-022313-2675sjlf	245	8	that	that	IN
cord-022313-2675sjlf	245	9	tunicamycin	tunicamycin	NN
cord-022313-2675sjlf	245	10	-	-	HYPH
cord-022313-2675sjlf	245	11	resistant	resistant	JJ
cord-022313-2675sjlf	245	12	mu	mu	NNS
cord-022313-2675sjlf	245	13	tants	tant	NNS
cord-022313-2675sjlf	245	14	can	can	MD
cord-022313-2675sjlf	245	15	be	be	VB
cord-022313-2675sjlf	245	16	isolated	isolate	VBN
cord-022313-2675sjlf	245	17	and	and	CC
cord-022313-2675sjlf	245	18	these	these	DT
cord-022313-2675sjlf	245	19	mutant	mutant	JJ
cord-022313-2675sjlf	245	20	cells	cell	NNS
cord-022313-2675sjlf	245	21	have	have	VBP
cord-022313-2675sjlf	245	22	amplified	amplify	VBN
cord-022313-2675sjlf	245	23	levels	level	NNS
cord-022313-2675sjlf	245	24	of	of	IN
cord-022313-2675sjlf	245	25	the	the	DT
cord-022313-2675sjlf	245	26	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	245	27	-	-	HYPH
cord-022313-2675sjlf	245	28	l	l	NN
cord-022313-2675sjlf	245	29	-	-	HYPH
cord-022313-2675sjlf	245	30	P	p	NN
cord-022313-2675sjlf	245	31	transferase	transferase	NN
cord-022313-2675sjlf	245	32	(	(	-LRB-
cord-022313-2675sjlf	245	33	117	117	CD
cord-022313-2675sjlf	245	34	)	)	-RRB-
cord-022313-2675sjlf	245	35	.	.	.
cord-022313-2675sjlf	246	1	Thus	thus	RB
cord-022313-2675sjlf	246	2	,	,	,
cord-022313-2675sjlf	246	3	it	-PRON-	PRP
cord-022313-2675sjlf	246	4	seems	seem	VBZ
cord-022313-2675sjlf	246	5	reasonable	reasonable	JJ
cord-022313-2675sjlf	246	6	to	to	TO
cord-022313-2675sjlf	246	7	assume	assume	VB
cord-022313-2675sjlf	246	8	that	that	IN
cord-022313-2675sjlf	246	9	the	the	DT
cord-022313-2675sjlf	246	10	level	level	NN
cord-022313-2675sjlf	246	11	of	of	IN
cord-022313-2675sjlf	246	12	this	this	DT
cord-022313-2675sjlf	246	13	enzyme	enzyme	NN
cord-022313-2675sjlf	246	14	,	,	,
cord-022313-2675sjlf	246	15	and	and	CC
cord-022313-2675sjlf	246	16	therefore	therefore	RB
cord-022313-2675sjlf	246	17	the	the	DT
cord-022313-2675sjlf	246	18	susceptibility	susceptibility	NN
cord-022313-2675sjlf	246	19	of	of	IN
cord-022313-2675sjlf	246	20	the	the	DT
cord-022313-2675sjlf	246	21	cell	cell	NN
cord-022313-2675sjlf	246	22	to	to	IN
cord-022313-2675sjlf	246	23	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	246	24	,	,	,
cord-022313-2675sjlf	246	25	may	may	MD
cord-022313-2675sjlf	246	26	vary	vary	VB
cord-022313-2675sjlf	246	27	from	from	IN
cord-022313-2675sjlf	246	28	cell	cell	NN
cord-022313-2675sjlf	246	29	to	to	IN
cord-022313-2675sjlf	246	30	cell	cell	NN
cord-022313-2675sjlf	246	31	or	or	CC
cord-022313-2675sjlf	246	32	from	from	IN
cord-022313-2675sjlf	246	33	tissue	tissue	NN
cord-022313-2675sjlf	246	34	to	to	IN
cord-022313-2675sjlf	246	35	tissue	tissue	NN
cord-022313-2675sjlf	246	36	.	.	.
cord-022313-2675sjlf	247	1	Something	something	NN
cord-022313-2675sjlf	247	2	else	else	RB
cord-022313-2675sjlf	247	3	to	to	TO
cord-022313-2675sjlf	247	4	consider	consider	VB
cord-022313-2675sjlf	247	5	when	when	WRB
cord-022313-2675sjlf	247	6	using	use	VBG
cord-022313-2675sjlf	247	7	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	247	8	for	for	IN
cord-022313-2675sjlf	247	9	functional	functional	JJ
cord-022313-2675sjlf	247	10	studies	study	NNS
cord-022313-2675sjlf	247	11	is	be	VBZ
cord-022313-2675sjlf	247	12	that	that	IN
cord-022313-2675sjlf	247	13	this	this	DT
cord-022313-2675sjlf	247	14	compound	compound	NN
cord-022313-2675sjlf	247	15	may	may	MD
cord-022313-2675sjlf	247	16	inhibit	inhibit	VB
cord-022313-2675sjlf	247	17	protein	protein	NN
cord-022313-2675sjlf	247	18	synthesis	synthesis	NN
cord-022313-2675sjlf	247	19	(	(	-LRB-
cord-022313-2675sjlf	247	20	118	118	CD
cord-022313-2675sjlf	247	21	)	)	-RRB-
cord-022313-2675sjlf	247	22	.	.	.
cord-022313-2675sjlf	248	1	For	for	IN
cord-022313-2675sjlf	248	2	this	this	DT
cord-022313-2675sjlf	248	3	reason	reason	NN
cord-022313-2675sjlf	248	4	,	,	,
cord-022313-2675sjlf	248	5	any	any	DT
cord-022313-2675sjlf	248	6	effects	effect	NNS
cord-022313-2675sjlf	248	7	on	on	IN
cord-022313-2675sjlf	248	8	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	248	9	function	function	NN
cord-022313-2675sjlf	248	10	should	should	MD
cord-022313-2675sjlf	248	11	be	be	VB
cord-022313-2675sjlf	248	12	thoroughly	thoroughly	RB
cord-022313-2675sjlf	248	13	examined	examine	VBN
cord-022313-2675sjlf	248	14	to	to	TO
cord-022313-2675sjlf	248	15	be	be	VB
cord-022313-2675sjlf	248	16	certain	certain	JJ
cord-022313-2675sjlf	248	17	that	that	IN
cord-022313-2675sjlf	248	18	they	-PRON-	PRP
cord-022313-2675sjlf	248	19	result	result	VBP
cord-022313-2675sjlf	248	20	from	from	IN
cord-022313-2675sjlf	248	21	the	the	DT
cord-022313-2675sjlf	248	22	absence	absence	NN
cord-022313-2675sjlf	248	23	of	of	IN
cord-022313-2675sjlf	248	24	carbohy	carbohy	NNP
cord-022313-2675sjlf	248	25	drate	drate	NNP
cord-022313-2675sjlf	248	26	,	,	,
cord-022313-2675sjlf	248	27	rather	rather	RB
cord-022313-2675sjlf	248	28	than	than	IN
cord-022313-2675sjlf	248	29	from	from	IN
cord-022313-2675sjlf	248	30	the	the	DT
cord-022313-2675sjlf	248	31	loss	loss	NN
cord-022313-2675sjlf	248	32	of	of	IN
cord-022313-2675sjlf	248	33	certain	certain	JJ
cord-022313-2675sjlf	248	34	proteins	protein	NNS
cord-022313-2675sjlf	248	35	.	.	.
cord-022313-2675sjlf	249	1	For	for	IN
cord-022313-2675sjlf	249	2	example	example	NN
cord-022313-2675sjlf	249	3	,	,	,
cord-022313-2675sjlf	249	4	in	in	IN
cord-022313-2675sjlf	249	5	some	some	DT
cord-022313-2675sjlf	249	6	of	of	IN
cord-022313-2675sjlf	249	7	the	the	DT
cord-022313-2675sjlf	249	8	various	various	JJ
cord-022313-2675sjlf	249	9	studies	study	NNS
cord-022313-2675sjlf	249	10	,	,	,
cord-022313-2675sjlf	249	11	at	at	IN
cord-022313-2675sjlf	249	12	tunicamycin	tunicamycin	NNP
cord-022313-2675sjlf	249	13	concentrations	concentration	NNS
cord-022313-2675sjlf	249	14	of	of	IN
cord-022313-2675sjlf	249	15	0.1	0.1	CD
cord-022313-2675sjlf	249	16	to	to	TO
cord-022313-2675sjlf	249	17	10	10	CD
cord-022313-2675sjlf	249	18	μ	μ	NN
cord-022313-2675sjlf	249	19	-	-	HYPH
cord-022313-2675sjlf	249	20	g	g	NN
cord-022313-2675sjlf	249	21	/	/	SYM
cord-022313-2675sjlf	249	22	ml	ml	NN
cord-022313-2675sjlf	249	23	,	,	,
cord-022313-2675sjlf	249	24	[	[	-LRB-
cord-022313-2675sjlf	249	25	3	3	CD
cord-022313-2675sjlf	249	26	H	h	NN
cord-022313-2675sjlf	249	27	]	]	-RRB-
cord-022313-2675sjlf	249	28	leucine	leucine	NN
cord-022313-2675sjlf	249	29	incorporation	incorporation	NN
cord-022313-2675sjlf	249	30	into	into	IN
cord-022313-2675sjlf	249	31	protein	protein	NN
cord-022313-2675sjlf	249	32	was	be	VBD
cord-022313-2675sjlf	249	33	inhibited	inhibit	VBN
cord-022313-2675sjlf	249	34	from	from	IN
cord-022313-2675sjlf	249	35	10	10	CD
cord-022313-2675sjlf	249	36	to	to	TO
cord-022313-2675sjlf	249	37	60	60	CD
cord-022313-2675sjlf	249	38	%	%	NN
cord-022313-2675sjlf	249	39	,	,	,
cord-022313-2675sjlf	249	40	while	while	IN
cord-022313-2675sjlf	249	41	glycosylation	glycosylation	NN
cord-022313-2675sjlf	249	42	was	be	VBD
cord-022313-2675sjlf	249	43	inhibited	inhibit	VBN
cord-022313-2675sjlf	249	44	from	from	IN
cord-022313-2675sjlf	249	45	70	70	CD
cord-022313-2675sjlf	249	46	to	to	TO
cord-022313-2675sjlf	249	47	90	90	CD
cord-022313-2675sjlf	249	48	%	%	NN
cord-022313-2675sjlf	249	49	.	.	.
cord-022313-2675sjlf	250	1	But	but	CC
cord-022313-2675sjlf	250	2	again	again	RB
cord-022313-2675sjlf	250	3	,	,	,
cord-022313-2675sjlf	250	4	the	the	DT
cord-022313-2675sjlf	250	5	important	important	JJ
cord-022313-2675sjlf	250	6	point	point	NN
cord-022313-2675sjlf	250	7	is	be	VBZ
cord-022313-2675sjlf	250	8	that	that	IN
cord-022313-2675sjlf	250	9	some	some	DT
cord-022313-2675sjlf	250	10	cell	cell	NN
cord-022313-2675sjlf	250	11	types	type	NNS
cord-022313-2675sjlf	250	12	are	be	VBP
cord-022313-2675sjlf	250	13	much	much	RB
cord-022313-2675sjlf	250	14	more	more	RBR
cord-022313-2675sjlf	250	15	sensitive	sensitive	JJ
cord-022313-2675sjlf	250	16	to	to	IN
cord-022313-2675sjlf	250	17	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	250	18	than	than	IN
cord-022313-2675sjlf	250	19	are	be	VBP
cord-022313-2675sjlf	250	20	other	other	JJ
cord-022313-2675sjlf	250	21	cell	cell	NN
cord-022313-2675sjlf	250	22	types	type	NNS
cord-022313-2675sjlf	250	23	.	.	.
cord-022313-2675sjlf	251	1	Perhaps	perhaps	RB
cord-022313-2675sjlf	251	2	one	one	CD
cord-022313-2675sjlf	251	3	control	control	NN
cord-022313-2675sjlf	251	4	for	for	IN
cord-022313-2675sjlf	251	5	some	some	DT
cord-022313-2675sjlf	251	6	of	of	IN
cord-022313-2675sjlf	251	7	these	these	DT
cord-022313-2675sjlf	251	8	studies	study	NNS
cord-022313-2675sjlf	251	9	would	would	MD
cord-022313-2675sjlf	251	10	be	be	VB
cord-022313-2675sjlf	251	11	to	to	TO
cord-022313-2675sjlf	251	12	use	use	VB
cord-022313-2675sjlf	251	13	other	other	JJ
cord-022313-2675sjlf	251	14	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	251	15	(	(	-LRB-
cord-022313-2675sjlf	251	16	i.e.	i.e.	FW
cord-022313-2675sjlf	251	17	,	,	,
cord-022313-2675sjlf	251	18	cycloheximide	cycloheximide	NN
cord-022313-2675sjlf	251	19	or	or	CC
cord-022313-2675sjlf	251	20	puromycin	puromycin	NNS
cord-022313-2675sjlf	251	21	)	)	-RRB-
cord-022313-2675sjlf	251	22	that	that	WDT
cord-022313-2675sjlf	251	23	are	be	VBP
cord-022313-2675sjlf	251	24	known	know	VBN
cord-022313-2675sjlf	251	25	to	to	TO
cord-022313-2675sjlf	251	26	block	block	VB
cord-022313-2675sjlf	251	27	protein	protein	NN
cord-022313-2675sjlf	251	28	synthesis	synthesis	NN
cord-022313-2675sjlf	251	29	but	but	CC
cord-022313-2675sjlf	251	30	do	do	VBP
cord-022313-2675sjlf	251	31	not	not	RB
cord-022313-2675sjlf	251	32	affect	affect	VB
cord-022313-2675sjlf	251	33	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	251	34	synthesis	synthesis	NN
cord-022313-2675sjlf	251	35	or	or	CC
cord-022313-2675sjlf	251	36	addition	addition	NN
cord-022313-2675sjlf	251	37	,	,	,
cord-022313-2675sjlf	251	38	or	or	CC
cord-022313-2675sjlf	251	39	some	some	DT
cord-022313-2675sjlf	251	40	other	other	JJ
cord-022313-2675sjlf	251	41	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	251	42	that	that	WDT
cord-022313-2675sjlf	251	43	mod	mod	NN
cord-022313-2675sjlf	251	44	ify	ify	VB
cord-022313-2675sjlf	251	45	the	the	DT
cord-022313-2675sjlf	251	46	structure	structure	NN
cord-022313-2675sjlf	251	47	of	of	IN
cord-022313-2675sjlf	251	48	the	the	DT
cord-022313-2675sjlf	251	49	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	251	50	chain	chain	NN
cord-022313-2675sjlf	251	51	,	,	,
cord-022313-2675sjlf	251	52	and	and	CC
cord-022313-2675sjlf	251	53	compare	compare	VB
cord-022313-2675sjlf	251	54	the	the	DT
cord-022313-2675sjlf	251	55	effects	effect	NNS
cord-022313-2675sjlf	251	56	of	of	IN
cord-022313-2675sjlf	251	57	these	these	DT
cord-022313-2675sjlf	251	58	compounds	compound	NNS
cord-022313-2675sjlf	251	59	with	with	IN
cord-022313-2675sjlf	251	60	those	those	DT
cord-022313-2675sjlf	251	61	of	of	IN
cord-022313-2675sjlf	251	62	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	251	63	on	on	IN
cord-022313-2675sjlf	251	64	the	the	DT
cord-022313-2675sjlf	251	65	function	function	NN
cord-022313-2675sjlf	251	66	of	of	IN
cord-022313-2675sjlf	251	67	the	the	DT
cord-022313-2675sjlf	251	68	particular	particular	JJ
cord-022313-2675sjlf	251	69	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	251	70	.	.	.
cord-022313-2675sjlf	252	1	The	the	DT
cord-022313-2675sjlf	252	2	results	result	NNS
cord-022313-2675sjlf	252	3	of	of	IN
cord-022313-2675sjlf	252	4	producing	produce	VBG
cord-022313-2675sjlf	252	5	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	252	6	in	in	IN
cord-022313-2675sjlf	252	7	cells	cell	NNS
cord-022313-2675sjlf	252	8	in	in	IN
cord-022313-2675sjlf	252	9	the	the	DT
cord-022313-2675sjlf	252	10	presence	presence	NN
cord-022313-2675sjlf	252	11	of	of	IN
cord-022313-2675sjlf	252	12	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	252	13	vary	vary	VBP
cord-022313-2675sjlf	252	14	considerably	considerably	RB
cord-022313-2675sjlf	252	15	depending	depend	VBG
cord-022313-2675sjlf	252	16	on	on	IN
cord-022313-2675sjlf	252	17	the	the	DT
cord-022313-2675sjlf	252	18	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	252	19	in	in	IN
cord-022313-2675sjlf	252	20	ques	ques	NNP
cord-022313-2675sjlf	252	21	tion	tion	NN
cord-022313-2675sjlf	252	22	.	.	.
cord-022313-2675sjlf	253	1	In	in	IN
cord-022313-2675sjlf	253	2	terms	term	NNS
cord-022313-2675sjlf	253	3	of	of	IN
cord-022313-2675sjlf	253	4	structural	structural	JJ
cord-022313-2675sjlf	253	5	studies	study	NNS
cord-022313-2675sjlf	253	6	,	,	,
cord-022313-2675sjlf	253	7	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	253	8	at	at	IN
cord-022313-2675sjlf	253	9	the	the	DT
cord-022313-2675sjlf	253	10	appropriate	appropriate	JJ
cord-022313-2675sjlf	253	11	concentration	concentration	NN
cord-022313-2675sjlf	253	12	seems	seem	VBZ
cord-022313-2675sjlf	253	13	to	to	TO
cord-022313-2675sjlf	253	14	prevent	prevent	VB
cord-022313-2675sjlf	253	15	glycosylation	glycosylation	NN
cord-022313-2675sjlf	253	16	of	of	IN
cord-022313-2675sjlf	253	17	all	all	DT
cord-022313-2675sjlf	253	18	N	n	NN
cord-022313-2675sjlf	253	19	-	-	HYPH
cord-022313-2675sjlf	253	20	linked	link	VBN
cord-022313-2675sjlf	253	21	glycopro	glycopro	NN
cord-022313-2675sjlf	253	22	teins	tein	NNS
cord-022313-2675sjlf	253	23	,	,	,
cord-022313-2675sjlf	253	24	regardless	regardless	RB
cord-022313-2675sjlf	253	25	of	of	IN
cord-022313-2675sjlf	253	26	the	the	DT
cord-022313-2675sjlf	253	27	biological	biological	JJ
cord-022313-2675sjlf	253	28	system	system	NN
cord-022313-2675sjlf	253	29	.	.	.
cord-022313-2675sjlf	254	1	However	however	RB
cord-022313-2675sjlf	254	2	,	,	,
cord-022313-2675sjlf	254	3	in	in	IN
cord-022313-2675sjlf	254	4	terms	term	NNS
cord-022313-2675sjlf	254	5	of	of	IN
cord-022313-2675sjlf	254	6	the	the	DT
cord-022313-2675sjlf	254	7	protein	protein	NN
cord-022313-2675sjlf	254	8	portion	portion	NN
cord-022313-2675sjlf	254	9	of	of	IN
cord-022313-2675sjlf	254	10	the	the	DT
cord-022313-2675sjlf	254	11	molecule	molecule	NN
cord-022313-2675sjlf	254	12	,	,	,
cord-022313-2675sjlf	254	13	some	some	DT
cord-022313-2675sjlf	254	14	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	254	15	are	be	VBP
cord-022313-2675sjlf	254	16	still	still	RB
cord-022313-2675sjlf	254	17	synthesized	synthesize	VBN
cord-022313-2675sjlf	254	18	at	at	IN
cord-022313-2675sjlf	254	19	a	a	DT
cord-022313-2675sjlf	254	20	normal	normal	JJ
cord-022313-2675sjlf	254	21	rate	rate	NN
cord-022313-2675sjlf	254	22	and	and	CC
cord-022313-2675sjlf	254	23	are	be	VBP
cord-022313-2675sjlf	254	24	still	still	RB
cord-022313-2675sjlf	254	25	secreted	secrete	VBN
cord-022313-2675sjlf	254	26	even	even	RB
cord-022313-2675sjlf	254	27	when	when	WRB
cord-022313-2675sjlf	254	28	they	-PRON-	PRP
cord-022313-2675sjlf	254	29	are	be	VBP
cord-022313-2675sjlf	254	30	not	not	RB
cord-022313-2675sjlf	254	31	glycosyl	glycosyl	JJ
cord-022313-2675sjlf	254	32	ated	ate	VBN
cord-022313-2675sjlf	254	33	(	(	-LRB-
cord-022313-2675sjlf	254	34	119	119	CD
cord-022313-2675sjlf	254	35	)	)	-RRB-
cord-022313-2675sjlf	254	36	.	.	.
cord-022313-2675sjlf	255	1	Thus	thus	RB
cord-022313-2675sjlf	255	2	,	,	,
cord-022313-2675sjlf	255	3	no	no	DT
cord-022313-2675sjlf	255	4	effect	effect	NN
cord-022313-2675sjlf	255	5	of	of	IN
cord-022313-2675sjlf	255	6	this	this	DT
cord-022313-2675sjlf	255	7	inhibitor	inhibitor	NN
cord-022313-2675sjlf	255	8	on	on	IN
cord-022313-2675sjlf	255	9	the	the	DT
cord-022313-2675sjlf	255	10	secretion	secretion	NN
cord-022313-2675sjlf	255	11	of	of	IN
cord-022313-2675sjlf	255	12	procolla	procolla	NNS
cord-022313-2675sjlf	255	13	gen	gen	NNP
cord-022313-2675sjlf	255	14	from	from	IN
cord-022313-2675sjlf	255	15	chick	chick	NNP
cord-022313-2675sjlf	255	16	embryo	embryo	NN
cord-022313-2675sjlf	255	17	cells	cell	NNS
cord-022313-2675sjlf	255	18	,	,	,
cord-022313-2675sjlf	255	19	secretion	secretion	NN
cord-022313-2675sjlf	255	20	of	of	IN
cord-022313-2675sjlf	255	21	a	a	DT
cord-022313-2675sjlf	255	22	number	number	NN
cord-022313-2675sjlf	255	23	of	of	IN
cord-022313-2675sjlf	255	24	serum	serum	NN
cord-022313-2675sjlf	255	25	proteins	protein	NNS
cord-022313-2675sjlf	255	26	from	from	IN
cord-022313-2675sjlf	255	27	rat	rat	NN
cord-022313-2675sjlf	255	28	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	255	29	,	,	,
cord-022313-2675sjlf	255	30	interferon	interferon	NN
cord-022313-2675sjlf	255	31	secretion	secretion	NN
cord-022313-2675sjlf	255	32	by	by	IN
cord-022313-2675sjlf	255	33	leukocytes	leukocyte	NNS
cord-022313-2675sjlf	255	34	or	or	CC
cord-022313-2675sjlf	255	35	L	l	NN
cord-022313-2675sjlf	255	36	cells	cell	NNS
cord-022313-2675sjlf	255	37	,	,	,
cord-022313-2675sjlf	255	38	secretion	secretion	NN
cord-022313-2675sjlf	255	39	of	of	IN
cord-022313-2675sjlf	255	40	the	the	DT
cord-022313-2675sjlf	255	41	enzyme	enzyme	NN
cord-022313-2675sjlf	255	42	/3-iV	/3-iv	CD
cord-022313-2675sjlf	255	43	-	-	HYPH
cord-022313-2675sjlf	255	44	acetylhexosaminidase	acetylhexosaminidase	NN
cord-022313-2675sjlf	255	45	by	by	IN
cord-022313-2675sjlf	255	46	fibroblasts	fibroblast	NNS
cord-022313-2675sjlf	255	47	,	,	,
cord-022313-2675sjlf	255	48	and	and	CC
cord-022313-2675sjlf	255	49	so	so	RB
cord-022313-2675sjlf	255	50	on	on	RB
cord-022313-2675sjlf	255	51	was	be	VBD
cord-022313-2675sjlf	255	52	observed	observe	VBN
cord-022313-2675sjlf	255	53	(	(	-LRB-
cord-022313-2675sjlf	255	54	120	120	CD
cord-022313-2675sjlf	255	55	)	)	-RRB-
cord-022313-2675sjlf	255	56	.	.	.
cord-022313-2675sjlf	256	1	The	the	DT
cord-022313-2675sjlf	256	2	conclusion	conclusion	NN
cord-022313-2675sjlf	256	3	here	here	RB
cord-022313-2675sjlf	256	4	is	be	VBZ
cord-022313-2675sjlf	256	5	that	that	IN
cord-022313-2675sjlf	256	6	a	a	DT
cord-022313-2675sjlf	256	7	number	number	NN
cord-022313-2675sjlf	256	8	of	of	IN
cord-022313-2675sjlf	256	9	different	different	JJ
cord-022313-2675sjlf	256	10	types	type	NNS
cord-022313-2675sjlf	256	11	of	of	IN
cord-022313-2675sjlf	256	12	cells	cell	NNS
cord-022313-2675sjlf	256	13	and	and	CC
cord-022313-2675sjlf	256	14	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	256	15	do	do	VBP
cord-022313-2675sjlf	256	16	not	not	RB
cord-022313-2675sjlf	256	17	require	require	VB
cord-022313-2675sjlf	256	18	their	-PRON-	PRP$
cord-022313-2675sjlf	256	19	carbohy	carbohy	NNP
cord-022313-2675sjlf	256	20	drate	drate	NNP
cord-022313-2675sjlf	256	21	for	for	IN
cord-022313-2675sjlf	256	22	either	either	CC
cord-022313-2675sjlf	256	23	folding	folding	NN
cord-022313-2675sjlf	256	24	or	or	CC
cord-022313-2675sjlf	256	25	conformation	conformation	NN
cord-022313-2675sjlf	256	26	and	and	CC
cord-022313-2675sjlf	256	27	appear	appear	VBP
cord-022313-2675sjlf	256	28	to	to	TO
cord-022313-2675sjlf	256	29	function	function	VB
cord-022313-2675sjlf	256	30	normally	normally	RB
cord-022313-2675sjlf	256	31	in	in	IN
cord-022313-2675sjlf	256	32	the	the	DT
cord-022313-2675sjlf	256	33	absence	absence	NN
cord-022313-2675sjlf	256	34	of	of	IN
cord-022313-2675sjlf	256	35	added	add	VBN
cord-022313-2675sjlf	256	36	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	256	37	.	.	.
cord-022313-2675sjlf	257	1	Some	some	DT
cord-022313-2675sjlf	257	2	proteins	protein	NNS
cord-022313-2675sjlf	257	3	,	,	,
cord-022313-2675sjlf	257	4	however	however	RB
cord-022313-2675sjlf	257	5	,	,	,
cord-022313-2675sjlf	257	6	are	be	VBP
cord-022313-2675sjlf	257	7	greatly	greatly	RB
cord-022313-2675sjlf	257	8	affected	affect	VBN
cord-022313-2675sjlf	257	9	by	by	IN
cord-022313-2675sjlf	257	10	the	the	DT
cord-022313-2675sjlf	257	11	absence	absence	NN
cord-022313-2675sjlf	257	12	of	of	IN
cord-022313-2675sjlf	257	13	carbo	carbo	NNP
cord-022313-2675sjlf	257	14	hydrate	hydrate	NNP
cord-022313-2675sjlf	257	15	.	.	.
cord-022313-2675sjlf	258	1	Thus	thus	RB
cord-022313-2675sjlf	258	2	,	,	,
cord-022313-2675sjlf	258	3	a	a	DT
cord-022313-2675sjlf	258	4	considerable	considerable	JJ
cord-022313-2675sjlf	258	5	decrease	decrease	NN
cord-022313-2675sjlf	258	6	in	in	IN
cord-022313-2675sjlf	258	7	the	the	DT
cord-022313-2675sjlf	258	8	rate	rate	NN
cord-022313-2675sjlf	258	9	of	of	IN
cord-022313-2675sjlf	258	10	secretion	secretion	NN
cord-022313-2675sjlf	258	11	of	of	IN
cord-022313-2675sjlf	258	12	IgE	IgE	NNP
cord-022313-2675sjlf	258	13	and	and	CC
cord-022313-2675sjlf	258	14	IgA	IgA	NNP
cord-022313-2675sjlf	258	15	by	by	IN
cord-022313-2675sjlf	258	16	mouse	mouse	NN
cord-022313-2675sjlf	258	17	and	and	CC
cord-022313-2675sjlf	258	18	rat	rat	NN
cord-022313-2675sjlf	258	19	plasma	plasma	NN
cord-022313-2675sjlf	258	20	cells	cell	NNS
cord-022313-2675sjlf	258	21	was	be	VBD
cord-022313-2675sjlf	258	22	observed	observe	VBN
cord-022313-2675sjlf	258	23	in	in	IN
cord-022313-2675sjlf	258	24	the	the	DT
cord-022313-2675sjlf	258	25	presence	presence	NN
cord-022313-2675sjlf	258	26	of	of	IN
cord-022313-2675sjlf	258	27	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	258	28	,	,	,
cord-022313-2675sjlf	258	29	as	as	IN
cord-022313-2675sjlf	258	30	was	be	VBD
cord-022313-2675sjlf	258	31	the	the	DT
cord-022313-2675sjlf	258	32	secretion	secretion	NN
cord-022313-2675sjlf	258	33	of	of	IN
cord-022313-2675sjlf	258	34	IgM	IgM	NNP
cord-022313-2675sjlf	258	35	in	in	IN
cord-022313-2675sjlf	258	36	hybridoma	hybridoma	NN
cord-022313-2675sjlf	258	37	cells	cell	NNS
cord-022313-2675sjlf	258	38	(	(	-LRB-
cord-022313-2675sjlf	258	39	121	121	CD
cord-022313-2675sjlf	258	40	)	)	-RRB-
cord-022313-2675sjlf	258	41	.	.	.
cord-022313-2675sjlf	259	1	One	one	CD
cord-022313-2675sjlf	259	2	rather	rather	RB
cord-022313-2675sjlf	259	3	strange	strange	JJ
cord-022313-2675sjlf	259	4	and	and	CC
cord-022313-2675sjlf	259	5	interesting	interesting	JJ
cord-022313-2675sjlf	259	6	result	result	NN
cord-022313-2675sjlf	259	7	that	that	WDT
cord-022313-2675sjlf	259	8	emerged	emerge	VBD
cord-022313-2675sjlf	259	9	from	from	IN
cord-022313-2675sjlf	259	10	these	these	DT
cord-022313-2675sjlf	259	11	studies	study	NNS
cord-022313-2675sjlf	259	12	was	be	VBD
cord-022313-2675sjlf	259	13	the	the	DT
cord-022313-2675sjlf	259	14	observation	observation	NN
cord-022313-2675sjlf	259	15	that	that	IN
cord-022313-2675sjlf	259	16	tunicamycin	tunicamycin	NNP
cord-022313-2675sjlf	259	17	inhibited	inhibit	VBD
cord-022313-2675sjlf	259	18	IgM	IgM	NNP
cord-022313-2675sjlf	259	19	secretion	secretion	NN
cord-022313-2675sjlf	259	20	in	in	IN
cord-022313-2675sjlf	259	21	hybridoma	hybridoma	NN
cord-022313-2675sjlf	259	22	cells	cell	NNS
cord-022313-2675sjlf	259	23	,	,	,
cord-022313-2675sjlf	259	24	but	but	CC
cord-022313-2675sjlf	259	25	did	do	VBD
cord-022313-2675sjlf	259	26	not	not	RB
cord-022313-2675sjlf	259	27	affect	affect	VB
cord-022313-2675sjlf	259	28	the	the	DT
cord-022313-2675sjlf	259	29	secretion	secretion	NN
cord-022313-2675sjlf	259	30	of	of	IN
cord-022313-2675sjlf	259	31	IgG.	IgG.	NNP
cord-022313-2675sjlf	260	1	These	these	DT
cord-022313-2675sjlf	260	2	results	result	NNS
cord-022313-2675sjlf	260	3	led	lead	VBD
cord-022313-2675sjlf	260	4	the	the	DT
cord-022313-2675sjlf	260	5	authors	author	NNS
cord-022313-2675sjlf	260	6	to	to	TO
cord-022313-2675sjlf	260	7	hypothesize	hypothesize	VB
cord-022313-2675sjlf	260	8	that	that	IN
cord-022313-2675sjlf	260	9	the	the	DT
cord-022313-2675sjlf	260	10	differential	differential	JJ
cord-022313-2675sjlf	260	11	effects	effect	NNS
cord-022313-2675sjlf	260	12	of	of	IN
cord-022313-2675sjlf	260	13	this	this	DT
cord-022313-2675sjlf	260	14	inhibi	inhibi	NNS
cord-022313-2675sjlf	260	15	tor	tor	NNP
cord-022313-2675sjlf	260	16	were	be	VBD
cord-022313-2675sjlf	260	17	due	due	JJ
cord-022313-2675sjlf	260	18	to	to	IN
cord-022313-2675sjlf	260	19	factors	factor	NNS
cord-022313-2675sjlf	260	20	intrinsic	intrinsic	JJ
cord-022313-2675sjlf	260	21	to	to	IN
cord-022313-2675sjlf	260	22	the	the	DT
cord-022313-2675sjlf	260	23	respective	respective	JJ
cord-022313-2675sjlf	260	24	heavy	heavy	JJ
cord-022313-2675sjlf	260	25	-	-	HYPH
cord-022313-2675sjlf	260	26	chain	chain	NN
cord-022313-2675sjlf	260	27	polypep	polypep	NN
cord-022313-2675sjlf	260	28	tides	tide	VBZ
cord-022313-2675sjlf	260	29	themselves	-PRON-	PRP
cord-022313-2675sjlf	260	30	,	,	,
cord-022313-2675sjlf	260	31	rather	rather	RB
cord-022313-2675sjlf	260	32	than	than	IN
cord-022313-2675sjlf	260	33	to	to	IN
cord-022313-2675sjlf	260	34	some	some	DT
cord-022313-2675sjlf	260	35	property	property	NN
cord-022313-2675sjlf	260	36	of	of	IN
cord-022313-2675sjlf	260	37	the	the	DT
cord-022313-2675sjlf	260	38	cells	cell	NNS
cord-022313-2675sjlf	260	39	(	(	-LRB-
cord-022313-2675sjlf	260	40	122	122	CD
cord-022313-2675sjlf	260	41	)	)	-RRB-
cord-022313-2675sjlf	260	42	.	.	.
cord-022313-2675sjlf	261	1	It	-PRON-	PRP
cord-022313-2675sjlf	261	2	would	would	MD
cord-022313-2675sjlf	261	3	seem	seem	VB
cord-022313-2675sjlf	261	4	likely	likely	JJ
cord-022313-2675sjlf	261	5	that	that	IN
cord-022313-2675sjlf	261	6	such	such	JJ
cord-022313-2675sjlf	261	7	factors	factor	NNS
cord-022313-2675sjlf	261	8	are	be	VBP
cord-022313-2675sjlf	261	9	related	relate	VBN
cord-022313-2675sjlf	261	10	to	to	IN
cord-022313-2675sjlf	261	11	the	the	DT
cord-022313-2675sjlf	261	12	conformation	conformation	NN
cord-022313-2675sjlf	261	13	of	of	IN
cord-022313-2675sjlf	261	14	the	the	DT
cord-022313-2675sjlf	261	15	respective	respective	JJ
cord-022313-2675sjlf	261	16	proteins	protein	NNS
cord-022313-2675sjlf	261	17	and	and	CC
cord-022313-2675sjlf	261	18	to	to	IN
cord-022313-2675sjlf	261	19	the	the	DT
cord-022313-2675sjlf	261	20	influence	influence	NN
cord-022313-2675sjlf	261	21	of	of	IN
cord-022313-2675sjlf	261	22	the	the	DT
cord-022313-2675sjlf	261	23	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	261	24	on	on	IN
cord-022313-2675sjlf	261	25	protein	protein	NN
cord-022313-2675sjlf	261	26	structure	structure	NN
cord-022313-2675sjlf	261	27	and/or	and/or	CC
cord-022313-2675sjlf	261	28	folding	folding	NN
cord-022313-2675sjlf	261	29	.	.	.
cord-022313-2675sjlf	262	1	Not	not	RB
cord-022313-2675sjlf	262	2	surprisingly	surprisingly	RB
cord-022313-2675sjlf	262	3	,	,	,
cord-022313-2675sjlf	262	4	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	262	5	also	also	RB
cord-022313-2675sjlf	262	6	has	have	VBZ
cord-022313-2675sjlf	262	7	dramatic	dramatic	JJ
cord-022313-2675sjlf	262	8	effects	effect	NNS
cord-022313-2675sjlf	262	9	on	on	IN
cord-022313-2675sjlf	262	10	some	some	DT
cord-022313-2675sjlf	262	11	membrane	membrane	NN
cord-022313-2675sjlf	262	12	receptors	receptor	NNS
cord-022313-2675sjlf	262	13	,	,	,
cord-022313-2675sjlf	262	14	such	such	JJ
cord-022313-2675sjlf	262	15	as	as	IN
cord-022313-2675sjlf	262	16	the	the	DT
cord-022313-2675sjlf	262	17	acetylcholine	acetylcholine	NN
cord-022313-2675sjlf	262	18	receptor	receptor	NN
cord-022313-2675sjlf	262	19	of	of	IN
cord-022313-2675sjlf	262	20	muscle	muscle	NN
cord-022313-2675sjlf	262	21	cells	cell	NNS
cord-022313-2675sjlf	262	22	(	(	-LRB-
cord-022313-2675sjlf	262	23	123	123	CD
cord-022313-2675sjlf	262	24	)	)	-RRB-
cord-022313-2675sjlf	262	25	,	,	,
cord-022313-2675sjlf	262	26	the	the	DT
cord-022313-2675sjlf	262	27	insulin	insulin	NN
cord-022313-2675sjlf	262	28	receptor	receptor	NN
cord-022313-2675sjlf	262	29	(	(	-LRB-
cord-022313-2675sjlf	262	30	124	124	CD
cord-022313-2675sjlf	262	31	)	)	-RRB-
cord-022313-2675sjlf	262	32	,	,	,
cord-022313-2675sjlf	262	33	the	the	DT
cord-022313-2675sjlf	262	34	receptor	receptor	NN
cord-022313-2675sjlf	262	35	for	for	IN
cord-022313-2675sjlf	262	36	low	low	JJ
cord-022313-2675sjlf	262	37	-	-	HYPH
cord-022313-2675sjlf	262	38	density	density	NN
cord-022313-2675sjlf	262	39	lipoproteins	lipoprotein	NNS
cord-022313-2675sjlf	262	40	(	(	-LRB-
cord-022313-2675sjlf	262	41	LDL	LDL	NNP
cord-022313-2675sjlf	262	42	)	)	-RRB-
cord-022313-2675sjlf	262	43	(	(	-LRB-
cord-022313-2675sjlf	262	44	125	125	CD
cord-022313-2675sjlf	262	45	)	)	-RRB-
cord-022313-2675sjlf	262	46	,	,	,
cord-022313-2675sjlf	262	47	and	and	CC
cord-022313-2675sjlf	262	48	the	the	DT
cord-022313-2675sjlf	262	49	receptor	receptor	NN
cord-022313-2675sjlf	262	50	for	for	IN
cord-022313-2675sjlf	262	51	nerve	nerve	NN
cord-022313-2675sjlf	262	52	growth	growth	NN
cord-022313-2675sjlf	262	53	factor	factor	NN
cord-022313-2675sjlf	262	54	(	(	-LRB-
cord-022313-2675sjlf	262	55	126	126	CD
cord-022313-2675sjlf	262	56	)	)	-RRB-
cord-022313-2675sjlf	262	57	,	,	,
cord-022313-2675sjlf	262	58	to	to	TO
cord-022313-2675sjlf	262	59	cite	cite	VB
cord-022313-2675sjlf	262	60	only	only	RB
cord-022313-2675sjlf	262	61	a	a	DT
cord-022313-2675sjlf	262	62	few	few	JJ
cord-022313-2675sjlf	262	63	examples	example	NNS
cord-022313-2675sjlf	262	64	.	.	.
cord-022313-2675sjlf	263	1	In	in	IN
cord-022313-2675sjlf	263	2	general	general	JJ
cord-022313-2675sjlf	263	3	,	,	,
cord-022313-2675sjlf	263	4	with	with	IN
cord-022313-2675sjlf	263	5	all	all	DT
cord-022313-2675sjlf	263	6	of	of	IN
cord-022313-2675sjlf	263	7	these	these	DT
cord-022313-2675sjlf	263	8	receptors	receptor	NNS
cord-022313-2675sjlf	263	9	,	,	,
cord-022313-2675sjlf	263	10	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	263	11	significantly	significantly	RB
cord-022313-2675sjlf	263	12	decreased	decrease	VBD
cord-022313-2675sjlf	263	13	the	the	DT
cord-022313-2675sjlf	263	14	number	number	NN
cord-022313-2675sjlf	263	15	of	of	IN
cord-022313-2675sjlf	263	16	receptor	receptor	NN
cord-022313-2675sjlf	263	17	molecules	molecule	NNS
cord-022313-2675sjlf	263	18	at	at	IN
cord-022313-2675sjlf	263	19	the	the	DT
cord-022313-2675sjlf	263	20	cell	cell	NN
cord-022313-2675sjlf	263	21	surface	surface	NN
cord-022313-2675sjlf	263	22	,	,	,
cord-022313-2675sjlf	263	23	but	but	CC
cord-022313-2675sjlf	263	24	did	do	VBD
cord-022313-2675sjlf	263	25	not	not	RB
cord-022313-2675sjlf	263	26	change	change	VB
cord-022313-2675sjlf	263	27	the	the	DT
cord-022313-2675sjlf	263	28	total	total	JJ
cord-022313-2675sjlf	263	29	number	number	NN
cord-022313-2675sjlf	263	30	of	of	IN
cord-022313-2675sjlf	263	31	receptors	receptor	NNS
cord-022313-2675sjlf	263	32	in	in	IN
cord-022313-2675sjlf	263	33	the	the	DT
cord-022313-2675sjlf	263	34	cells	cell	NNS
cord-022313-2675sjlf	263	35	or	or	CC
cord-022313-2675sjlf	263	36	the	the	DT
cord-022313-2675sjlf	263	37	binding	bind	VBG
cord-022313-2675sjlf	263	38	affinity	affinity	NN
cord-022313-2675sjlf	263	39	of	of	IN
cord-022313-2675sjlf	263	40	those	those	DT
cord-022313-2675sjlf	263	41	receptors	receptor	NNS
cord-022313-2675sjlf	263	42	that	that	WDT
cord-022313-2675sjlf	263	43	were	be	VBD
cord-022313-2675sjlf	263	44	present	present	JJ
cord-022313-2675sjlf	263	45	in	in	IN
cord-022313-2675sjlf	263	46	the	the	DT
cord-022313-2675sjlf	263	47	plasma	plasma	NN
cord-022313-2675sjlf	263	48	membrane	membrane	NN
cord-022313-2675sjlf	263	49	.	.	.
cord-022313-2675sjlf	264	1	In	in	IN
cord-022313-2675sjlf	264	2	some	some	DT
cord-022313-2675sjlf	264	3	of	of	IN
cord-022313-2675sjlf	264	4	these	these	DT
cord-022313-2675sjlf	264	5	studies	study	NNS
cord-022313-2675sjlf	264	6	,	,	,
cord-022313-2675sjlf	264	7	the	the	DT
cord-022313-2675sjlf	264	8	effects	effect	NNS
cord-022313-2675sjlf	264	9	of	of	IN
cord-022313-2675sjlf	264	10	tuni	tuni	JJ
cord-022313-2675sjlf	264	11	camycin	camycin	NNS
cord-022313-2675sjlf	264	12	were	be	VBD
cord-022313-2675sjlf	264	13	reversible	reversible	JJ
cord-022313-2675sjlf	264	14	,	,	,
cord-022313-2675sjlf	264	15	and	and	CC
cord-022313-2675sjlf	264	16	in	in	IN
cord-022313-2675sjlf	264	17	one	one	CD
cord-022313-2675sjlf	264	18	study	study	NN
cord-022313-2675sjlf	264	19	with	with	IN
cord-022313-2675sjlf	264	20	the	the	DT
cord-022313-2675sjlf	264	21	insulin	insulin	NN
cord-022313-2675sjlf	264	22	receptor	receptor	NN
cord-022313-2675sjlf	264	23	,	,	,
cord-022313-2675sjlf	264	24	it	-PRON-	PRP
cord-022313-2675sjlf	264	25	appeared	appear	VBD
cord-022313-2675sjlf	264	26	that	that	IN
cord-022313-2675sjlf	264	27	the	the	DT
cord-022313-2675sjlf	264	28	nonglycosylated	nonglycosylated	JJ
cord-022313-2675sjlf	264	29	receptor	receptor	NN
cord-022313-2675sjlf	264	30	could	could	MD
cord-022313-2675sjlf	264	31	become	become	VB
cord-022313-2675sjlf	264	32	glycosylated	glycosylate	VBN
cord-022313-2675sjlf	264	33	after	after	IN
cord-022313-2675sjlf	264	34	removal	removal	NN
cord-022313-2675sjlf	264	35	of	of	IN
cord-022313-2675sjlf	264	36	the	the	DT
cord-022313-2675sjlf	264	37	drug	drug	NN
cord-022313-2675sjlf	264	38	(	(	-LRB-
cord-022313-2675sjlf	264	39	127	127	CD
cord-022313-2675sjlf	264	40	)	)	-RRB-
cord-022313-2675sjlf	264	41	.	.	.
cord-022313-2675sjlf	265	1	That	that	DT
cord-022313-2675sjlf	265	2	would	would	MD
cord-022313-2675sjlf	265	3	suggest	suggest	VB
cord-022313-2675sjlf	265	4	that	that	IN
cord-022313-2675sjlf	265	5	in	in	IN
cord-022313-2675sjlf	265	6	some	some	DT
cord-022313-2675sjlf	265	7	cases	case	NNS
cord-022313-2675sjlf	265	8	,	,	,
cord-022313-2675sjlf	265	9	proteins	protein	NNS
cord-022313-2675sjlf	265	10	might	may	MD
cord-022313-2675sjlf	265	11	be	be	VB
cord-022313-2675sjlf	265	12	glycosylated	glycosylate	VBN
cord-022313-2675sjlf	265	13	post	post	NN
cord-022313-2675sjlf	265	14	-	-	NN
cord-022313-2675sjlf	265	15	translationally	translationally	RB
cord-022313-2675sjlf	265	16	.	.	.
cord-022313-2675sjlf	266	1	Since	since	IN
cord-022313-2675sjlf	266	2	there	there	EX
cord-022313-2675sjlf	266	3	is	be	VBZ
cord-022313-2675sjlf	266	4	some	some	DT
cord-022313-2675sjlf	266	5	precedence	precedence	NN
cord-022313-2675sjlf	266	6	for	for	IN
cord-022313-2675sjlf	266	7	surface	surface	NN
cord-022313-2675sjlf	266	8	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	266	9	being	be	VBG
cord-022313-2675sjlf	266	10	endocytosed	endocytose	VBN
cord-022313-2675sjlf	266	11	and	and	CC
cord-022313-2675sjlf	266	12	recycled	recycle	VBN
cord-022313-2675sjlf	266	13	back	back	RB
cord-022313-2675sjlf	266	14	through	through	IN
cord-022313-2675sjlf	266	15	the	the	DT
cord-022313-2675sjlf	266	16	Golgi	Golgi	NNP
cord-022313-2675sjlf	266	17	(	(	-LRB-
cord-022313-2675sjlf	266	18	and	and	CC
cord-022313-2675sjlf	266	19	perhaps	perhaps	RB
cord-022313-2675sjlf	266	20	the	the	DT
cord-022313-2675sjlf	266	21	ER	ER	NNP
cord-022313-2675sjlf	266	22	)	)	-RRB-
cord-022313-2675sjlf	266	23	(	(	-LRB-
cord-022313-2675sjlf	266	24	128	128	CD
cord-022313-2675sjlf	266	25	)	)	-RRB-
cord-022313-2675sjlf	266	26	,	,	,
cord-022313-2675sjlf	266	27	it	-PRON-	PRP
cord-022313-2675sjlf	266	28	is	be	VBZ
cord-022313-2675sjlf	266	29	conceivable	conceivable	JJ
cord-022313-2675sjlf	266	30	that	that	DT
cord-022313-2675sjlf	266	31	glycosylation	glycosylation	NN
cord-022313-2675sjlf	266	32	could	could	MD
cord-022313-2675sjlf	266	33	occur	occur	VB
cord-022313-2675sjlf	266	34	on	on	IN
cord-022313-2675sjlf	266	35	some	some	DT
cord-022313-2675sjlf	266	36	exposed	expose	VBN
cord-022313-2675sjlf	266	37	asparagine	asparagine	NN
cord-022313-2675sjlf	266	38	sequons	sequon	NNS
cord-022313-2675sjlf	266	39	.	.	.
cord-022313-2675sjlf	267	1	Probably	probably	RB
cord-022313-2675sjlf	267	2	one	one	CD
cord-022313-2675sjlf	267	3	of	of	IN
cord-022313-2675sjlf	267	4	the	the	DT
cord-022313-2675sjlf	267	5	reasons	reason	NNS
cord-022313-2675sjlf	267	6	for	for	IN
cord-022313-2675sjlf	267	7	the	the	DT
cord-022313-2675sjlf	267	8	great	great	JJ
cord-022313-2675sjlf	267	9	variation	variation	NN
cord-022313-2675sjlf	267	10	in	in	IN
cord-022313-2675sjlf	267	11	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	267	12	effects	effect	NNS
cord-022313-2675sjlf	267	13	on	on	IN
cord-022313-2675sjlf	267	14	protein	protein	NN
cord-022313-2675sjlf	267	15	function	function	NN
cord-022313-2675sjlf	267	16	is	be	VBZ
cord-022313-2675sjlf	267	17	that	that	IN
cord-022313-2675sjlf	267	18	some	some	DT
cord-022313-2675sjlf	267	19	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	267	20	require	require	VBP
cord-022313-2675sjlf	267	21	their	-PRON-	PRP$
cord-022313-2675sjlf	267	22	re	re	VBN
cord-022313-2675sjlf	267	23	linked	link	VBN
cord-022313-2675sjlf	267	24	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	267	25	for	for	IN
cord-022313-2675sjlf	267	26	stability	stability	NN
cord-022313-2675sjlf	267	27	(	(	-LRB-
cord-022313-2675sjlf	267	28	or	or	CC
cord-022313-2675sjlf	267	29	longevity	longevity	NN
cord-022313-2675sjlf	267	30	)	)	-RRB-
cord-022313-2675sjlf	267	31	,	,	,
cord-022313-2675sjlf	267	32	and	and	CC
cord-022313-2675sjlf	267	33	in	in	IN
cord-022313-2675sjlf	267	34	the	the	DT
cord-022313-2675sjlf	267	35	absence	absence	NN
cord-022313-2675sjlf	267	36	of	of	IN
cord-022313-2675sjlf	267	37	glycosylation	glycosylation	NN
cord-022313-2675sjlf	267	38	these	these	DT
cord-022313-2675sjlf	267	39	proteins	protein	NNS
cord-022313-2675sjlf	267	40	are	be	VBP
cord-022313-2675sjlf	267	41	rapidly	rapidly	RB
cord-022313-2675sjlf	267	42	degraded	degrade	VBN
cord-022313-2675sjlf	267	43	.	.	.
cord-022313-2675sjlf	268	1	That	that	RB
cord-022313-2675sjlf	268	2	is	is	RB
cord-022313-2675sjlf	268	3	,	,	,
cord-022313-2675sjlf	268	4	the	the	DT
cord-022313-2675sjlf	268	5	carbo	carbo	NN
cord-022313-2675sjlf	268	6	hydrate	hydrate	NN
cord-022313-2675sjlf	268	7	may	may	MD
cord-022313-2675sjlf	268	8	protect	protect	VB
cord-022313-2675sjlf	268	9	or	or	CC
cord-022313-2675sjlf	268	10	somehow	somehow	RB
cord-022313-2675sjlf	268	11	prevent	prevent	VB
cord-022313-2675sjlf	268	12	the	the	DT
cord-022313-2675sjlf	268	13	degradative	degradative	JJ
cord-022313-2675sjlf	268	14	enzymes	enzyme	NNS
cord-022313-2675sjlf	268	15	from	from	IN
cord-022313-2675sjlf	268	16	attacking	attack	VBG
cord-022313-2675sjlf	268	17	glycosylated	glycosylated	JJ
cord-022313-2675sjlf	268	18	proteins	protein	NNS
cord-022313-2675sjlf	268	19	.	.	.
cord-022313-2675sjlf	269	1	Such	such	JJ
cord-022313-2675sjlf	269	2	has	have	VBZ
cord-022313-2675sjlf	269	3	been	be	VBN
cord-022313-2675sjlf	269	4	suggested	suggest	VBN
cord-022313-2675sjlf	269	5	to	to	TO
cord-022313-2675sjlf	269	6	be	be	VB
cord-022313-2675sjlf	269	7	the	the	DT
cord-022313-2675sjlf	269	8	case	case	NN
cord-022313-2675sjlf	269	9	for	for	IN
cord-022313-2675sjlf	269	10	fibronectin	fibronectin	NN
cord-022313-2675sjlf	269	11	,	,	,
cord-022313-2675sjlf	269	12	acetylcholine	acetylcholine	NN
cord-022313-2675sjlf	269	13	receptor	receptor	NN
cord-022313-2675sjlf	269	14	,	,	,
cord-022313-2675sjlf	269	15	influenza	influenza	NN
cord-022313-2675sjlf	269	16	viral	viral	JJ
cord-022313-2675sjlf	269	17	hemagglutinin	hemagglutinin	NN
cord-022313-2675sjlf	269	18	,	,	,
cord-022313-2675sjlf	269	19	and	and	CC
cord-022313-2675sjlf	269	20	various	various	JJ
cord-022313-2675sjlf	269	21	immunoglobulins	immunoglobulin	NNS
cord-022313-2675sjlf	269	22	,	,	,
cord-022313-2675sjlf	269	23	just	just	RB
cord-022313-2675sjlf	269	24	to	to	TO
cord-022313-2675sjlf	269	25	cite	cite	VB
cord-022313-2675sjlf	269	26	a	a	DT
cord-022313-2675sjlf	269	27	few	few	JJ
cord-022313-2675sjlf	269	28	examples	example	NNS
cord-022313-2675sjlf	269	29	(	(	-LRB-
cord-022313-2675sjlf	269	30	129	129	CD
cord-022313-2675sjlf	269	31	)	)	-RRB-
cord-022313-2675sjlf	269	32	.	.	.
cord-022313-2675sjlf	270	1	In	in	IN
cord-022313-2675sjlf	270	2	fact	fact	NN
cord-022313-2675sjlf	270	3	,	,	,
cord-022313-2675sjlf	270	4	in	in	IN
cord-022313-2675sjlf	270	5	the	the	DT
cord-022313-2675sjlf	270	6	influenza	influenza	NN
cord-022313-2675sjlf	270	7	system	system	NN
cord-022313-2675sjlf	270	8	,	,	,
cord-022313-2675sjlf	270	9	it	-PRON-	PRP
cord-022313-2675sjlf	270	10	was	be	VBD
cord-022313-2675sjlf	270	11	observed	observe	VBN
cord-022313-2675sjlf	270	12	that	that	IN
cord-022313-2675sjlf	270	13	when	when	WRB
cord-022313-2675sjlf	270	14	viral	viral	JJ
cord-022313-2675sjlf	270	15	replication	replication	NN
cord-022313-2675sjlf	270	16	was	be	VBD
cord-022313-2675sjlf	270	17	examined	examine	VBN
cord-022313-2675sjlf	270	18	in	in	IN
cord-022313-2675sjlf	270	19	the	the	DT
cord-022313-2675sjlf	270	20	presence	presence	NN
cord-022313-2675sjlf	270	21	of	of	IN
cord-022313-2675sjlf	270	22	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	270	23	,	,	,
cord-022313-2675sjlf	270	24	the	the	DT
cord-022313-2675sjlf	270	25	viral	viral	JJ
cord-022313-2675sjlf	270	26	envelope	envelope	NN
cord-022313-2675sjlf	270	27	glyco	glyco	NNP
cord-022313-2675sjlf	270	28	proteins	protein	NNS
cord-022313-2675sjlf	270	29	could	could	MD
cord-022313-2675sjlf	270	30	not	not	RB
cord-022313-2675sjlf	270	31	be	be	VB
cord-022313-2675sjlf	270	32	detected	detect	VBN
cord-022313-2675sjlf	270	33	.	.	.
cord-022313-2675sjlf	271	1	However	however	RB
cord-022313-2675sjlf	271	2	,	,	,
cord-022313-2675sjlf	271	3	when	when	WRB
cord-022313-2675sjlf	271	4	a	a	DT
cord-022313-2675sjlf	271	5	protease	protease	NN
cord-022313-2675sjlf	271	6	inhibitor	inhibitor	NN
cord-022313-2675sjlf	271	7	,	,	,
cord-022313-2675sjlf	271	8	such	such	JJ
cord-022313-2675sjlf	271	9	as	as	IN
cord-022313-2675sjlf	271	10	TCPK	TCPK	NNP
cord-022313-2675sjlf	271	11	or	or	CC
cord-022313-2675sjlf	271	12	leupeptin	leupeptin	NN
cord-022313-2675sjlf	271	13	,	,	,
cord-022313-2675sjlf	271	14	was	be	VBD
cord-022313-2675sjlf	271	15	added	add	VBN
cord-022313-2675sjlf	271	16	to	to	IN
cord-022313-2675sjlf	271	17	the	the	DT
cord-022313-2675sjlf	271	18	cells	cell	NNS
cord-022313-2675sjlf	271	19	along	along	IN
cord-022313-2675sjlf	271	20	with	with	IN
cord-022313-2675sjlf	271	21	the	the	DT
cord-022313-2675sjlf	271	22	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	271	23	,	,	,
cord-022313-2675sjlf	271	24	the	the	DT
cord-022313-2675sjlf	271	25	viral	viral	JJ
cord-022313-2675sjlf	271	26	proteins	protein	NNS
cord-022313-2675sjlf	271	27	in	in	IN
cord-022313-2675sjlf	271	28	their	-PRON-	PRP$
cord-022313-2675sjlf	271	29	nonglycosylated	nonglycosylate	VBN
cord-022313-2675sjlf	271	30	form	form	NN
cord-022313-2675sjlf	271	31	could	could	MD
cord-022313-2675sjlf	271	32	be	be	VB
cord-022313-2675sjlf	271	33	detected	detect	VBN
cord-022313-2675sjlf	271	34	(	(	-LRB-
cord-022313-2675sjlf	271	35	130	130	CD
cord-022313-2675sjlf	271	36	)	)	-RRB-
cord-022313-2675sjlf	271	37	.	.	.
cord-022313-2675sjlf	272	1	These	these	DT
cord-022313-2675sjlf	272	2	studies	study	NNS
cord-022313-2675sjlf	272	3	and	and	CC
cord-022313-2675sjlf	272	4	others	other	NNS
cord-022313-2675sjlf	272	5	cited	cite	VBN
cord-022313-2675sjlf	272	6	above	above	IN
cord-022313-2675sjlf	272	7	all	all	DT
cord-022313-2675sjlf	272	8	indicate	indicate	VBP
cord-022313-2675sjlf	272	9	that	that	IN
cord-022313-2675sjlf	272	10	the	the	DT
cord-022313-2675sjlf	272	11	influence	influence	NN
cord-022313-2675sjlf	272	12	of	of	IN
cord-022313-2675sjlf	272	13	the	the	DT
cord-022313-2675sjlf	272	14	N	n	NN
cord-022313-2675sjlf	272	15	-	-	HYPH
cord-022313-2675sjlf	272	16	linked	link	VBN
cord-022313-2675sjlf	272	17	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	272	18	on	on	IN
cord-022313-2675sjlf	272	19	the	the	DT
cord-022313-2675sjlf	272	20	protein	protein	NN
cord-022313-2675sjlf	272	21	in	in	IN
cord-022313-2675sjlf	272	22	question	question	NN
cord-022313-2675sjlf	272	23	depends	depend	VBZ
cord-022313-2675sjlf	272	24	on	on	IN
cord-022313-2675sjlf	272	25	its	-PRON-	PRP$
cord-022313-2675sjlf	272	26	amino	amino	NN
cord-022313-2675sjlf	272	27	acid	acid	NN
cord-022313-2675sjlf	272	28	sequence	sequence	NN
cord-022313-2675sjlf	272	29	,	,	,
cord-022313-2675sjlf	272	30	which	which	WDT
cord-022313-2675sjlf	272	31	in	in	IN
cord-022313-2675sjlf	272	32	turn	turn	NN
cord-022313-2675sjlf	272	33	determines	determine	VBZ
cord-022313-2675sjlf	272	34	folding	folding	NN
cord-022313-2675sjlf	272	35	and	and	CC
cord-022313-2675sjlf	272	36	conformation	conformation	NN
cord-022313-2675sjlf	272	37	.	.	.
cord-022313-2675sjlf	273	1	Thus	thus	RB
cord-022313-2675sjlf	273	2	,	,	,
cord-022313-2675sjlf	273	3	the	the	DT
cord-022313-2675sjlf	273	4	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	273	5	may	may	MD
cord-022313-2675sjlf	273	6	play	play	VB
cord-022313-2675sjlf	273	7	a	a	DT
cord-022313-2675sjlf	273	8	much	much	RB
cord-022313-2675sjlf	273	9	greater	great	JJR
cord-022313-2675sjlf	273	10	role	role	NN
cord-022313-2675sjlf	273	11	in	in	IN
cord-022313-2675sjlf	273	12	affecting	affect	VBG
cord-022313-2675sjlf	273	13	or	or	CC
cord-022313-2675sjlf	273	14	maintaining	maintain	VBG
cord-022313-2675sjlf	273	15	the	the	DT
cord-022313-2675sjlf	273	16	conformation	conformation	NN
cord-022313-2675sjlf	273	17	of	of	IN
cord-022313-2675sjlf	273	18	some	some	DT
cord-022313-2675sjlf	273	19	proteins	protein	NNS
cord-022313-2675sjlf	273	20	than	than	IN
cord-022313-2675sjlf	273	21	that	that	DT
cord-022313-2675sjlf	273	22	of	of	IN
cord-022313-2675sjlf	273	23	others	other	NNS
cord-022313-2675sjlf	273	24	.	.	.
cord-022313-2675sjlf	274	1	One	one	CD
cord-022313-2675sjlf	274	2	study	study	NN
cord-022313-2675sjlf	274	3	that	that	WDT
cord-022313-2675sjlf	274	4	provides	provide	VBZ
cord-022313-2675sjlf	274	5	strong	strong	JJ
cord-022313-2675sjlf	274	6	support	support	NN
cord-022313-2675sjlf	274	7	for	for	IN
cord-022313-2675sjlf	274	8	the	the	DT
cord-022313-2675sjlf	274	9	hypothesis	hypothesis	NN
cord-022313-2675sjlf	274	10	that	that	IN
cord-022313-2675sjlf	274	11	the	the	DT
cord-022313-2675sjlf	274	12	amino	amino	NN
cord-022313-2675sjlf	274	13	acid	acid	NN
cord-022313-2675sjlf	274	14	sequence	sequence	NN
cord-022313-2675sjlf	274	15	of	of	IN
cord-022313-2675sjlf	274	16	the	the	DT
cord-022313-2675sjlf	274	17	protein	protein	NN
cord-022313-2675sjlf	274	18	determines	determine	VBZ
cord-022313-2675sjlf	274	19	what	what	WDT
cord-022313-2675sjlf	274	20	type	type	NN
cord-022313-2675sjlf	274	21	of	of	IN
cord-022313-2675sjlf	274	22	and	and	CC
cord-022313-2675sjlf	274	23	how	how	WRB
cord-022313-2675sjlf	274	24	important	important	JJ
cord-022313-2675sjlf	274	25	a	a	DT
cord-022313-2675sjlf	274	26	role	role	NN
cord-022313-2675sjlf	274	27	the	the	DT
cord-022313-2675sjlf	274	28	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	274	29	plays	play	VBZ
cord-022313-2675sjlf	274	30	in	in	IN
cord-022313-2675sjlf	274	31	the	the	DT
cord-022313-2675sjlf	274	32	function	function	NN
cord-022313-2675sjlf	274	33	of	of	IN
cord-022313-2675sjlf	274	34	the	the	DT
cord-022313-2675sjlf	274	35	glycopro	glycopro	NNP
cord-022313-2675sjlf	274	36	tein	tein	NNP
cord-022313-2675sjlf	274	37	was	be	VBD
cord-022313-2675sjlf	274	38	done	do	VBN
cord-022313-2675sjlf	274	39	using	use	VBG
cord-022313-2675sjlf	274	40	various	various	JJ
cord-022313-2675sjlf	274	41	temperature	temperature	NN
cord-022313-2675sjlf	274	42	-	-	HYPH
cord-022313-2675sjlf	274	43	sensitive	sensitive	JJ
cord-022313-2675sjlf	274	44	mutants	mutant	NNS
cord-022313-2675sjlf	274	45	of	of	IN
cord-022313-2675sjlf	274	46	vesicular	vesicular	JJ
cord-022313-2675sjlf	274	47	stomatitis	stomatitis	NN
cord-022313-2675sjlf	274	48	virus	virus	NN
cord-022313-2675sjlf	274	49	(	(	-LRB-
cord-022313-2675sjlf	274	50	VSV	VSV	NNP
cord-022313-2675sjlf	274	51	)	)	-RRB-
cord-022313-2675sjlf	274	52	that	that	WDT
cord-022313-2675sjlf	274	53	were	be	VBD
cord-022313-2675sjlf	274	54	grown	grow	VBN
cord-022313-2675sjlf	274	55	in	in	IN
cord-022313-2675sjlf	274	56	the	the	DT
cord-022313-2675sjlf	274	57	presence	presence	NN
cord-022313-2675sjlf	274	58	of	of	IN
cord-022313-2675sjlf	274	59	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	274	60	.	.	.
cord-022313-2675sjlf	275	1	With	with	IN
cord-022313-2675sjlf	275	2	one	one	CD
cord-022313-2675sjlf	275	3	strain	strain	NN
cord-022313-2675sjlf	275	4	of	of	IN
cord-022313-2675sjlf	275	5	VSV	VSV	NNP
cord-022313-2675sjlf	275	6	(	(	-LRB-
cord-022313-2675sjlf	275	7	called	call	VBN
cord-022313-2675sjlf	275	8	the	the	DT
cord-022313-2675sjlf	275	9	San	San	NNP
cord-022313-2675sjlf	275	10	Juan	Juan	NNP
cord-022313-2675sjlf	275	11	strain	strain	NN
cord-022313-2675sjlf	275	12	)	)	-RRB-
cord-022313-2675sjlf	275	13	,	,	,
cord-022313-2675sjlf	275	14	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	275	15	prevented	prevent	VBD
cord-022313-2675sjlf	275	16	viral	viral	JJ
cord-022313-2675sjlf	275	17	replication	replication	NN
cord-022313-2675sjlf	275	18	by	by	IN
cord-022313-2675sjlf	275	19	more	more	JJR
cord-022313-2675sjlf	275	20	than	than	IN
cord-022313-2675sjlf	275	21	90	90	CD
cord-022313-2675sjlf	275	22	%	%	NN
cord-022313-2675sjlf	275	23	when	when	WRB
cord-022313-2675sjlf	275	24	the	the	DT
cord-022313-2675sjlf	275	25	virus	virus	NN
cord-022313-2675sjlf	275	26	was	be	VBD
cord-022313-2675sjlf	275	27	grown	grow	VBN
cord-022313-2675sjlf	275	28	at	at	IN
cord-022313-2675sjlf	275	29	either	either	DT
cord-022313-2675sjlf	275	30	38	38	CD
cord-022313-2675sjlf	275	31	or	or	CC
cord-022313-2675sjlf	275	32	30	30	CD
cord-022313-2675sjlf	275	33	°	°	NN
cord-022313-2675sjlf	275	34	C	c	NN
cord-022313-2675sjlf	275	35	.	.	.
cord-022313-2675sjlf	276	1	However	however	RB
cord-022313-2675sjlf	276	2	,	,	,
cord-022313-2675sjlf	276	3	with	with	IN
cord-022313-2675sjlf	276	4	another	another	DT
cord-022313-2675sjlf	276	5	strain	strain	NN
cord-022313-2675sjlf	276	6	(	(	-LRB-
cord-022313-2675sjlf	276	7	called	call	VBN
cord-022313-2675sjlf	276	8	the	the	DT
cord-022313-2675sjlf	276	9	Orsay	Orsay	NNP
cord-022313-2675sjlf	276	10	strain	strain	NN
cord-022313-2675sjlf	276	11	)	)	-RRB-
cord-022313-2675sjlf	276	12	,	,	,
cord-022313-2675sjlf	276	13	the	the	DT
cord-022313-2675sjlf	276	14	drug	drug	NN
cord-022313-2675sjlf	276	15	inhibited	inhibit	VBD
cord-022313-2675sjlf	276	16	viral	viral	JJ
cord-022313-2675sjlf	276	17	replication	replication	NN
cord-022313-2675sjlf	276	18	by	by	IN
cord-022313-2675sjlf	276	19	90	90	CD
cord-022313-2675sjlf	276	20	%	%	NN
cord-022313-2675sjlf	276	21	when	when	WRB
cord-022313-2675sjlf	276	22	the	the	DT
cord-022313-2675sjlf	276	23	virus	virus	NN
cord-022313-2675sjlf	276	24	was	be	VBD
cord-022313-2675sjlf	276	25	grown	grow	VBN
cord-022313-2675sjlf	276	26	at	at	IN
cord-022313-2675sjlf	276	27	37	37	CD
cord-022313-2675sjlf	276	28	°	°	NN
cord-022313-2675sjlf	276	29	C	c	NN
cord-022313-2675sjlf	276	30	,	,	,
cord-022313-2675sjlf	276	31	but	but	CC
cord-022313-2675sjlf	276	32	there	there	EX
cord-022313-2675sjlf	276	33	was	be	VBD
cord-022313-2675sjlf	276	34	only	only	RB
cord-022313-2675sjlf	276	35	30	30	CD
cord-022313-2675sjlf	276	36	to	to	TO
cord-022313-2675sjlf	276	37	50	50	CD
cord-022313-2675sjlf	276	38	%	%	NN
cord-022313-2675sjlf	276	39	inhibition	inhibition	NN
cord-022313-2675sjlf	276	40	at	at	IN
cord-022313-2675sjlf	276	41	30	30	CD
cord-022313-2675sjlf	276	42	°	°	NN
cord-022313-2675sjlf	276	43	C	c	NN
cord-022313-2675sjlf	276	44	.	.	.
cord-022313-2675sjlf	277	1	Furthermore	furthermore	RB
cord-022313-2675sjlf	277	2	,	,	,
cord-022313-2675sjlf	277	3	when	when	WRB
cord-022313-2675sjlf	277	4	this	this	DT
cord-022313-2675sjlf	277	5	virus	virus	NN
cord-022313-2675sjlf	277	6	was	be	VBD
cord-022313-2675sjlf	277	7	grown	grow	VBN
cord-022313-2675sjlf	277	8	in	in	IN
cord-022313-2675sjlf	277	9	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	277	10	at	at	IN
cord-022313-2675sjlf	277	11	30	30	CD
cord-022313-2675sjlf	277	12	°	°	NN
cord-022313-2675sjlf	277	13	C	c	NN
cord-022313-2675sjlf	277	14	,	,	,
cord-022313-2675sjlf	277	15	the	the	DT
cord-022313-2675sjlf	277	16	nonglycosylated	nonglycosylate	VBN
cord-022313-2675sjlf	277	17	viral	viral	JJ
cord-022313-2675sjlf	277	18	envelope	envelope	NN
cord-022313-2675sjlf	277	19	protein	protein	NN
cord-022313-2675sjlf	277	20	(	(	-LRB-
cord-022313-2675sjlf	277	21	G	g	NN
cord-022313-2675sjlf	277	22	protein	protein	NN
cord-022313-2675sjlf	277	23	)	)	-RRB-
cord-022313-2675sjlf	277	24	was	be	VBD
cord-022313-2675sjlf	277	25	detected	detect	VBN
cord-022313-2675sjlf	277	26	at	at	IN
cord-022313-2675sjlf	277	27	the	the	DT
cord-022313-2675sjlf	277	28	host	host	NN
cord-022313-2675sjlf	277	29	cell	cell	NN
cord-022313-2675sjlf	277	30	surface	surface	NN
cord-022313-2675sjlf	277	31	,	,	,
cord-022313-2675sjlf	277	32	indicating	indicate	VBG
cord-022313-2675sjlf	277	33	that	that	IN
cord-022313-2675sjlf	277	34	it	-PRON-	PRP
cord-022313-2675sjlf	277	35	was	be	VBD
cord-022313-2675sjlf	277	36	synthesized	synthesize	VBN
cord-022313-2675sjlf	277	37	and	and	CC
cord-022313-2675sjlf	277	38	targeted	target	VBN
cord-022313-2675sjlf	277	39	in	in	IN
cord-022313-2675sjlf	277	40	the	the	DT
cord-022313-2675sjlf	277	41	normal	normal	JJ
cord-022313-2675sjlf	277	42	fashion	fashion	NN
cord-022313-2675sjlf	277	43	.	.	.
cord-022313-2675sjlf	278	1	However	however	RB
cord-022313-2675sjlf	278	2	,	,	,
cord-022313-2675sjlf	278	3	at	at	IN
cord-022313-2675sjlf	278	4	37	37	CD
cord-022313-2675sjlf	278	5	°	°	NN
cord-022313-2675sjlf	278	6	C	c	NN
cord-022313-2675sjlf	278	7	,	,	,
cord-022313-2675sjlf	278	8	this	this	DT
cord-022313-2675sjlf	278	9	protein	protein	NN
cord-022313-2675sjlf	278	10	could	could	MD
cord-022313-2675sjlf	278	11	not	not	RB
cord-022313-2675sjlf	278	12	be	be	VB
cord-022313-2675sjlf	278	13	detected	detect	VBN
cord-022313-2675sjlf	278	14	at	at	IN
cord-022313-2675sjlf	278	15	the	the	DT
cord-022313-2675sjlf	278	16	cell	cell	NN
cord-022313-2675sjlf	278	17	surface	surface	NN
cord-022313-2675sjlf	278	18	.	.	.
cord-022313-2675sjlf	279	1	Finally	finally	RB
cord-022313-2675sjlf	279	2	,	,	,
cord-022313-2675sjlf	279	3	studies	study	NNS
cord-022313-2675sjlf	279	4	on	on	IN
cord-022313-2675sjlf	279	5	the	the	DT
cord-022313-2675sjlf	279	6	physical	physical	JJ
cord-022313-2675sjlf	279	7	properties	property	NNS
cord-022313-2675sjlf	279	8	of	of	IN
cord-022313-2675sjlf	279	9	these	these	DT
cord-022313-2675sjlf	279	10	various	various	JJ
cord-022313-2675sjlf	279	11	nonglycosylated	nonglycosylated	JJ
cord-022313-2675sjlf	279	12	proteins	protein	NNS
cord-022313-2675sjlf	279	13	also	also	RB
cord-022313-2675sjlf	279	14	indicated	indicate	VBD
cord-022313-2675sjlf	279	15	that	that	IN
cord-022313-2675sjlf	279	16	these	these	DT
cord-022313-2675sjlf	279	17	proteins	protein	NNS
cord-022313-2675sjlf	279	18	differed	differ	VBD
cord-022313-2675sjlf	279	19	markedely	markedely	RB
cord-022313-2675sjlf	279	20	in	in	IN
cord-022313-2675sjlf	279	21	their	-PRON-	PRP$
cord-022313-2675sjlf	279	22	solubility	solubility	NN
cord-022313-2675sjlf	279	23	in	in	IN
cord-022313-2675sjlf	279	24	detergents	detergent	NNS
cord-022313-2675sjlf	279	25	such	such	JJ
cord-022313-2675sjlf	279	26	as	as	IN
cord-022313-2675sjlf	279	27	Triton	Triton	NNP
cord-022313-2675sjlf	279	28	X-114	X-114	VBZ
cord-022313-2675sjlf	279	29	at	at	IN
cord-022313-2675sjlf	279	30	the	the	DT
cord-022313-2675sjlf	279	31	different	different	JJ
cord-022313-2675sjlf	279	32	temperatures	temperature	NNS
cord-022313-2675sjlf	279	33	(	(	-LRB-
cord-022313-2675sjlf	279	34	131	131	CD
cord-022313-2675sjlf	279	35	)	)	-RRB-
cord-022313-2675sjlf	279	36	.	.	.
cord-022313-2675sjlf	280	1	The	the	DT
cord-022313-2675sjlf	280	2	probable	probable	JJ
cord-022313-2675sjlf	280	3	explana	explana	JJ
cord-022313-2675sjlf	280	4	tion	tion	NN
cord-022313-2675sjlf	280	5	for	for	IN
cord-022313-2675sjlf	280	6	such	such	JJ
cord-022313-2675sjlf	280	7	results	result	NNS
cord-022313-2675sjlf	280	8	is	be	VBZ
cord-022313-2675sjlf	280	9	that	that	IN
cord-022313-2675sjlf	280	10	the	the	DT
cord-022313-2675sjlf	280	11	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	280	12	has	have	VBZ
cord-022313-2675sjlf	280	13	a	a	DT
cord-022313-2675sjlf	280	14	significant	significant	JJ
cord-022313-2675sjlf	280	15	role	role	NN
cord-022313-2675sjlf	280	16	in	in	IN
cord-022313-2675sjlf	280	17	providing	provide	VBG
cord-022313-2675sjlf	280	18	a	a	DT
cord-022313-2675sjlf	280	19	conformation	conformation	NN
cord-022313-2675sjlf	280	20	that	that	WDT
cord-022313-2675sjlf	280	21	has	have	VBZ
cord-022313-2675sjlf	280	22	increased	increase	VBN
cord-022313-2675sjlf	280	23	solubility	solubility	NN
cord-022313-2675sjlf	280	24	as	as	RB
cord-022313-2675sjlf	280	25	well	well	RB
cord-022313-2675sjlf	280	26	as	as	IN
cord-022313-2675sjlf	280	27	stability	stability	NN
cord-022313-2675sjlf	280	28	.	.	.
cord-022313-2675sjlf	281	1	Five	five	CD
cord-022313-2675sjlf	281	2	other	other	JJ
cord-022313-2675sjlf	281	3	antibiotics	antibiotic	NNS
cord-022313-2675sjlf	281	4	have	have	VBP
cord-022313-2675sjlf	281	5	been	be	VBN
cord-022313-2675sjlf	281	6	described	describe	VBN
cord-022313-2675sjlf	281	7	that	that	WDT
cord-022313-2675sjlf	281	8	are	be	VBP
cord-022313-2675sjlf	281	9	now	now	RB
cord-022313-2675sjlf	281	10	known	know	VBN
cord-022313-2675sjlf	281	11	to	to	TO
cord-022313-2675sjlf	281	12	be	be	VB
cord-022313-2675sjlf	281	13	structurally	structurally	RB
cord-022313-2675sjlf	281	14	and	and	CC
cord-022313-2675sjlf	281	15	functionally	functionally	RB
cord-022313-2675sjlf	281	16	related	related	JJ
cord-022313-2675sjlf	281	17	to	to	IN
cord-022313-2675sjlf	281	18	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	281	19	.	.	.
cord-022313-2675sjlf	282	1	These	these	DT
cord-022313-2675sjlf	282	2	antibiotics	antibiotic	NNS
cord-022313-2675sjlf	282	3	are	be	VBP
cord-022313-2675sjlf	282	4	streptoviridin	streptoviridin	NNS
cord-022313-2675sjlf	282	5	(	(	-LRB-
cord-022313-2675sjlf	282	6	132	132	CD
cord-022313-2675sjlf	282	7	)	)	-RRB-
cord-022313-2675sjlf	282	8	,	,	,
cord-022313-2675sjlf	282	9	mycospocidin	mycospocidin	NNP
cord-022313-2675sjlf	282	10	(	(	-LRB-
cord-022313-2675sjlf	282	11	133	133	CD
cord-022313-2675sjlf	282	12	)	)	-RRB-
cord-022313-2675sjlf	282	13	,	,	,
cord-022313-2675sjlf	282	14	antibiotic	antibiotic	JJ
cord-022313-2675sjlf	282	15	24101	24101	CD
cord-022313-2675sjlf	282	16	(	(	-LRB-
cord-022313-2675sjlf	282	17	134	134	CD
cord-022313-2675sjlf	282	18	)	)	-RRB-
cord-022313-2675sjlf	282	19	,	,	,
cord-022313-2675sjlf	282	20	antibiotic	antibiotic	JJ
cord-022313-2675sjlf	282	21	MM	MM	NNP
cord-022313-2675sjlf	282	22	19290	19290	CD
cord-022313-2675sjlf	282	23	(	(	-LRB-
cord-022313-2675sjlf	282	24	135	135	CD
cord-022313-2675sjlf	282	25	)	)	-RRB-
cord-022313-2675sjlf	282	26	,	,	,
cord-022313-2675sjlf	282	27	and	and	CC
cord-022313-2675sjlf	282	28	corynetoxin	corynetoxin	NNP
cord-022313-2675sjlf	282	29	(	(	-LRB-
cord-022313-2675sjlf	282	30	136	136	CD
cord-022313-2675sjlf	282	31	)	)	-RRB-
cord-022313-2675sjlf	282	32	.	.	.
cord-022313-2675sjlf	283	1	All	all	DT
cord-022313-2675sjlf	283	2	of	of	IN
cord-022313-2675sjlf	283	3	these	these	DT
cord-022313-2675sjlf	283	4	com	com	NN
cord-022313-2675sjlf	283	5	pounds	pound	NNS
cord-022313-2675sjlf	283	6	have	have	VBP
cord-022313-2675sjlf	283	7	the	the	DT
cord-022313-2675sjlf	283	8	same	same	JJ
cord-022313-2675sjlf	283	9	general	general	JJ
cord-022313-2675sjlf	283	10	structure	structure	NN
cord-022313-2675sjlf	283	11	as	as	IN
cord-022313-2675sjlf	283	12	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	283	13	,	,	,
cord-022313-2675sjlf	283	14	but	but	CC
cord-022313-2675sjlf	283	15	they	-PRON-	PRP
cord-022313-2675sjlf	283	16	differ	differ	VBP
cord-022313-2675sjlf	283	17	in	in	IN
cord-022313-2675sjlf	283	18	the	the	DT
cord-022313-2675sjlf	283	19	nature	nature	NN
cord-022313-2675sjlf	283	20	of	of	IN
cord-022313-2675sjlf	283	21	the	the	DT
cord-022313-2675sjlf	283	22	fatty	fatty	JJ
cord-022313-2675sjlf	283	23	acids	acid	NNS
cord-022313-2675sjlf	283	24	attached	attach	VBN
cord-022313-2675sjlf	283	25	to	to	IN
cord-022313-2675sjlf	283	26	the	the	DT
cord-022313-2675sjlf	283	27	tunicamine	tunicamine	NN
cord-022313-2675sjlf	283	28	.	.	.
cord-022313-2675sjlf	284	1	Thus	thus	RB
cord-022313-2675sjlf	284	2	,	,	,
cord-022313-2675sjlf	284	3	in	in	IN
cord-022313-2675sjlf	284	4	some	some	DT
cord-022313-2675sjlf	284	5	cases	case	NNS
cord-022313-2675sjlf	284	6	,	,	,
cord-022313-2675sjlf	284	7	they	-PRON-	PRP
cord-022313-2675sjlf	284	8	may	may	MD
cord-022313-2675sjlf	284	9	be	be	VB
cord-022313-2675sjlf	284	10	identical	identical	JJ
cord-022313-2675sjlf	284	11	to	to	IN
cord-022313-2675sjlf	284	12	the	the	DT
cord-022313-2675sjlf	284	13	various	various	JJ
cord-022313-2675sjlf	284	14	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	284	15	homologs	homolog	NNS
cord-022313-2675sjlf	284	16	discussed	discuss	VBN
cord-022313-2675sjlf	284	17	earlier	early	RBR
cord-022313-2675sjlf	284	18	.	.	.
cord-022313-2675sjlf	285	1	For	for	IN
cord-022313-2675sjlf	285	2	example	example	NN
cord-022313-2675sjlf	285	3	,	,	,
cord-022313-2675sjlf	285	4	the	the	DT
cord-022313-2675sjlf	285	5	streptoviridin	streptoviridin	NNP
cord-022313-2675sjlf	285	6	components	component	NNS
cord-022313-2675sjlf	285	7	have	have	VBP
cord-022313-2675sjlf	285	8	shorter	short	JJR
cord-022313-2675sjlf	285	9	chain	chain	NN
cord-022313-2675sjlf	285	10	fatty	fatty	JJ
cord-022313-2675sjlf	285	11	acids	acid	NNS
cord-022313-2675sjlf	285	12	than	than	IN
cord-022313-2675sjlf	285	13	the	the	DT
cord-022313-2675sjlf	285	14	tunicamycins	tunicamycin	NNS
cord-022313-2675sjlf	285	15	,	,	,
cord-022313-2675sjlf	285	16	as	as	IN
cord-022313-2675sjlf	285	17	evidenced	evidence	VBN
cord-022313-2675sjlf	285	18	by	by	IN
cord-022313-2675sjlf	285	19	the	the	DT
cord-022313-2675sjlf	285	20	fact	fact	NN
cord-022313-2675sjlf	285	21	that	that	IN
cord-022313-2675sjlf	285	22	their	-PRON-	PRP$
cord-022313-2675sjlf	285	23	molecular	molecular	JJ
cord-022313-2675sjlf	285	24	weights	weight	NNS
cord-022313-2675sjlf	285	25	range	range	VBP
cord-022313-2675sjlf	285	26	from	from	IN
cord-022313-2675sjlf	285	27	790	790	CD
cord-022313-2675sjlf	285	28	to	to	IN
cord-022313-2675sjlf	285	29	814	814	CD
cord-022313-2675sjlf	285	30	,	,	,
cord-022313-2675sjlf	285	31	whereas	whereas	IN
cord-022313-2675sjlf	285	32	those	those	DT
cord-022313-2675sjlf	285	33	of	of	IN
cord-022313-2675sjlf	285	34	tunicamycins	tunicamycin	NNS
cord-022313-2675sjlf	285	35	are	be	VBP
cord-022313-2675sjlf	285	36	from	from	IN
cord-022313-2675sjlf	285	37	802	802	CD
cord-022313-2675sjlf	285	38	to	to	IN
cord-022313-2675sjlf	285	39	858	858	CD
cord-022313-2675sjlf	285	40	(	(	-LRB-
cord-022313-2675sjlf	285	41	22	22	CD
cord-022313-2675sjlf	285	42	,	,	,
cord-022313-2675sjlf	285	43	132	132	CD
cord-022313-2675sjlf	285	44	)	)	-RRB-
cord-022313-2675sjlf	285	45	.	.	.
cord-022313-2675sjlf	286	1	On	on	IN
cord-022313-2675sjlf	286	2	the	the	DT
cord-022313-2675sjlf	286	3	other	other	JJ
cord-022313-2675sjlf	286	4	hand	hand	NN
cord-022313-2675sjlf	286	5	,	,	,
cord-022313-2675sjlf	286	6	HPLC	HPLC	NNP
cord-022313-2675sjlf	286	7	comparison	comparison	NN
cord-022313-2675sjlf	286	8	of	of	IN
cord-022313-2675sjlf	286	9	the	the	DT
cord-022313-2675sjlf	286	10	mycospocidin	mycospocidin	NNP
cord-022313-2675sjlf	286	11	components	component	NNS
cord-022313-2675sjlf	286	12	with	with	IN
cord-022313-2675sjlf	286	13	those	those	DT
cord-022313-2675sjlf	286	14	from	from	IN
cord-022313-2675sjlf	286	15	the	the	DT
cord-022313-2675sjlf	286	16	tuni	tuni	NNP
cord-022313-2675sjlf	286	17	camycin	camycin	NNS
cord-022313-2675sjlf	286	18	complex	complex	NNP
cord-022313-2675sjlf	286	19	showed	show	VBD
cord-022313-2675sjlf	286	20	a	a	DT
cord-022313-2675sjlf	286	21	number	number	NN
cord-022313-2675sjlf	286	22	of	of	IN
cord-022313-2675sjlf	286	23	identical	identical	JJ
cord-022313-2675sjlf	286	24	components	component	NNS
cord-022313-2675sjlf	286	25	(	(	-LRB-
cord-022313-2675sjlf	286	26	133	133	CD
cord-022313-2675sjlf	286	27	)	)	-RRB-
cord-022313-2675sjlf	286	28	.	.	.
cord-022313-2675sjlf	287	1	The	the	DT
cord-022313-2675sjlf	287	2	corynetoxins	corynetoxin	NNS
cord-022313-2675sjlf	287	3	are	be	VBP
cord-022313-2675sjlf	287	4	an	an	DT
cord-022313-2675sjlf	287	5	interesting	interesting	JJ
cord-022313-2675sjlf	287	6	group	group	NN
cord-022313-2675sjlf	287	7	of	of	IN
cord-022313-2675sjlf	287	8	tunicamycin	tunicamycin	NN
cord-022313-2675sjlf	287	9	-	-	HYPH
cord-022313-2675sjlf	287	10	related	relate	VBN
cord-022313-2675sjlf	287	11	com	com	NN
cord-022313-2675sjlf	287	12	pounds	pound	NNS
cord-022313-2675sjlf	287	13	that	that	WDT
cord-022313-2675sjlf	287	14	appear	appear	VBP
cord-022313-2675sjlf	287	15	to	to	TO
cord-022313-2675sjlf	287	16	be	be	VB
cord-022313-2675sjlf	287	17	involved	involve	VBN
cord-022313-2675sjlf	287	18	in	in	IN
cord-022313-2675sjlf	287	19	or	or	CC
cord-022313-2675sjlf	287	20	responsible	responsible	JJ
cord-022313-2675sjlf	287	21	for	for	IN
cord-022313-2675sjlf	287	22	ryegrass	ryegrass	NN
cord-022313-2675sjlf	287	23	toxicity	toxicity	NN
cord-022313-2675sjlf	287	24	.	.	.
cord-022313-2675sjlf	288	1	In	in	IN
cord-022313-2675sjlf	288	2	this	this	DT
cord-022313-2675sjlf	288	3	case	case	NN
cord-022313-2675sjlf	288	4	,	,	,
cord-022313-2675sjlf	288	5	the	the	DT
cord-022313-2675sjlf	288	6	developing	develop	VBG
cord-022313-2675sjlf	288	7	seed	seed	NN
cord-022313-2675sjlf	288	8	heads	head	NNS
cord-022313-2675sjlf	288	9	of	of	IN
cord-022313-2675sjlf	288	10	annual	annual	JJ
cord-022313-2675sjlf	288	11	ryegrass	ryegrass	NN
cord-022313-2675sjlf	288	12	may	may	MD
cord-022313-2675sjlf	288	13	be	be	VB
cord-022313-2675sjlf	288	14	invaded	invade	VBN
cord-022313-2675sjlf	288	15	by	by	IN
cord-022313-2675sjlf	288	16	a	a	DT
cord-022313-2675sjlf	288	17	nematode	nematode	NN
cord-022313-2675sjlf	288	18	which	which	WDT
cord-022313-2675sjlf	288	19	then	then	RB
cord-022313-2675sjlf	288	20	causes	cause	VBZ
cord-022313-2675sjlf	288	21	a	a	DT
cord-022313-2675sjlf	288	22	gall	gall	NN
cord-022313-2675sjlf	288	23	to	to	TO
cord-022313-2675sjlf	288	24	be	be	VB
cord-022313-2675sjlf	288	25	produced	produce	VBN
cord-022313-2675sjlf	288	26	.	.	.
cord-022313-2675sjlf	289	1	Some	some	DT
cord-022313-2675sjlf	289	2	of	of	IN
cord-022313-2675sjlf	289	3	the	the	DT
cord-022313-2675sjlf	289	4	nematodes	nematode	NNS
cord-022313-2675sjlf	289	5	carry	carry	VBP
cord-022313-2675sjlf	289	6	the	the	DT
cord-022313-2675sjlf	289	7	bacterium	bacterium	NN
cord-022313-2675sjlf	289	8	Corynebacterium	Corynebacterium	NNP
cord-022313-2675sjlf	289	9	rathayi	rathayi	NN
cord-022313-2675sjlf	289	10	,	,	,
cord-022313-2675sjlf	289	11	which	which	WDT
cord-022313-2675sjlf	289	12	produces	produce	VBZ
cord-022313-2675sjlf	289	13	the	the	DT
cord-022313-2675sjlf	289	14	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	289	15	analog	analog	NN
cord-022313-2675sjlf	289	16	corynetoxin	corynetoxin	NNP
cord-022313-2675sjlf	289	17	.	.	.
cord-022313-2675sjlf	290	1	The	the	DT
cord-022313-2675sjlf	290	2	corynetoxins	corynetoxin	NNS
cord-022313-2675sjlf	290	3	are	be	VBP
cord-022313-2675sjlf	290	4	apparantly	apparantly	RB
cord-022313-2675sjlf	290	5	toxic	toxic	JJ
cord-022313-2675sjlf	290	6	to	to	IN
cord-022313-2675sjlf	290	7	sheep	sheep	NNS
cord-022313-2675sjlf	290	8	that	that	WDT
cord-022313-2675sjlf	290	9	eat	eat	VBP
cord-022313-2675sjlf	290	10	the	the	DT
cord-022313-2675sjlf	290	11	infected	infect	VBN
cord-022313-2675sjlf	290	12	ryegrass	ryegrass	NN
cord-022313-2675sjlf	290	13	(	(	-LRB-
cord-022313-2675sjlf	290	14	136	136	CD
cord-022313-2675sjlf	290	15	)	)	-RRB-
cord-022313-2675sjlf	290	16	.	.	.
cord-022313-2675sjlf	291	1	All	all	DT
cord-022313-2675sjlf	291	2	of	of	IN
cord-022313-2675sjlf	291	3	these	these	DT
cord-022313-2675sjlf	291	4	compounds	compound	NNS
cord-022313-2675sjlf	291	5	appear	appear	VBP
cord-022313-2675sjlf	291	6	to	to	TO
cord-022313-2675sjlf	291	7	have	have	VB
cord-022313-2675sjlf	291	8	the	the	DT
cord-022313-2675sjlf	291	9	same	same	JJ
cord-022313-2675sjlf	291	10	action	action	NN
cord-022313-2675sjlf	291	11	as	as	IN
cord-022313-2675sjlf	291	12	tuni	tuni	NNP
cord-022313-2675sjlf	291	13	camycin	camycin	NNS
cord-022313-2675sjlf	291	14	,	,	,
cord-022313-2675sjlf	291	15	i.e.	i.e.	FW
cord-022313-2675sjlf	291	16	,	,	,
cord-022313-2675sjlf	291	17	to	to	TO
cord-022313-2675sjlf	291	18	inhibit	inhibit	VB
cord-022313-2675sjlf	291	19	the	the	DT
cord-022313-2675sjlf	291	20	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	291	21	-	-	HYPH
cord-022313-2675sjlf	291	22	l	l	NN
cord-022313-2675sjlf	291	23	-	-	HYPH
cord-022313-2675sjlf	291	24	P	p	NN
cord-022313-2675sjlf	291	25	transferase	transferase	NN
cord-022313-2675sjlf	291	26	.	.	.
cord-022313-2675sjlf	292	1	Detailed	detailed	JJ
cord-022313-2675sjlf	292	2	studies	study	NNS
cord-022313-2675sjlf	292	3	on	on	IN
cord-022313-2675sjlf	292	4	the	the	DT
cord-022313-2675sjlf	292	5	mechanism	mechanism	NN
cord-022313-2675sjlf	292	6	of	of	IN
cord-022313-2675sjlf	292	7	action	action	NN
cord-022313-2675sjlf	292	8	were	be	VBD
cord-022313-2675sjlf	292	9	done	do	VBN
cord-022313-2675sjlf	292	10	with	with	IN
cord-022313-2675sjlf	292	11	streptoviridin	streptoviridin	NNS
cord-022313-2675sjlf	292	12	and	and	CC
cord-022313-2675sjlf	292	13	this	this	DT
cord-022313-2675sjlf	292	14	inhibitor	inhibitor	NN
cord-022313-2675sjlf	292	15	was	be	VBD
cord-022313-2675sjlf	292	16	compared	compare	VBN
cord-022313-2675sjlf	292	17	with	with	IN
cord-022313-2675sjlf	292	18	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	292	19	on	on	IN
cord-022313-2675sjlf	292	20	the	the	DT
cord-022313-2675sjlf	292	21	crude	crude	NN
cord-022313-2675sjlf	292	22	and	and	CC
cord-022313-2675sjlf	292	23	partially	partially	RB
cord-022313-2675sjlf	292	24	purified	purify	VBN
cord-022313-2675sjlf	292	25	preparations	preparation	NNS
cord-022313-2675sjlf	292	26	of	of	IN
cord-022313-2675sjlf	292	27	the	the	DT
cord-022313-2675sjlf	292	28	enzyme	enzyme	NN
cord-022313-2675sjlf	292	29	,	,	,
cord-022313-2675sjlf	292	30	as	as	RB
cord-022313-2675sjlf	292	31	well	well	RB
cord-022313-2675sjlf	292	32	as	as	IN
cord-022313-2675sjlf	292	33	in	in	IN
cord-022313-2675sjlf	292	34	cell	cell	NN
cord-022313-2675sjlf	292	35	culture	culture	NN
cord-022313-2675sjlf	292	36	systems	system	NNS
cord-022313-2675sjlf	292	37	(	(	-LRB-
cord-022313-2675sjlf	292	38	115	115	CD
cord-022313-2675sjlf	292	39	)	)	-RRB-
cord-022313-2675sjlf	292	40	.	.	.
cord-022313-2675sjlf	293	1	As	as	IN
cord-022313-2675sjlf	293	2	indicated	indicate	VBN
cord-022313-2675sjlf	293	3	above	above	RB
cord-022313-2675sjlf	293	4	for	for	IN
cord-022313-2675sjlf	293	5	the	the	DT
cord-022313-2675sjlf	293	6	various	various	JJ
cord-022313-2675sjlf	293	7	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	293	8	homologs	homolog	NNS
cord-022313-2675sjlf	293	9	,	,	,
cord-022313-2675sjlf	293	10	this	this	DT
cord-022313-2675sjlf	293	11	group	group	NN
cord-022313-2675sjlf	293	12	of	of	IN
cord-022313-2675sjlf	293	13	analogs	analog	NNS
cord-022313-2675sjlf	293	14	also	also	RB
cord-022313-2675sjlf	293	15	showed	show	VBD
cord-022313-2675sjlf	293	16	differences	difference	NNS
cord-022313-2675sjlf	293	17	in	in	IN
cord-022313-2675sjlf	293	18	inhibitory	inhibitory	JJ
cord-022313-2675sjlf	293	19	activity	activity	NN
cord-022313-2675sjlf	293	20	,	,	,
cord-022313-2675sjlf	293	21	and	and	CC
cord-022313-2675sjlf	293	22	those	those	DT
cord-022313-2675sjlf	293	23	compounds	compound	NNS
cord-022313-2675sjlf	293	24	with	with	IN
cord-022313-2675sjlf	293	25	the	the	DT
cord-022313-2675sjlf	293	26	longer	long	JJR
cord-022313-2675sjlf	293	27	chain	chain	NN
cord-022313-2675sjlf	293	28	fatty	fatty	JJ
cord-022313-2675sjlf	293	29	acids	acid	NNS
cord-022313-2675sjlf	293	30	were	be	VBD
cord-022313-2675sjlf	293	31	more	more	RBR
cord-022313-2675sjlf	293	32	effective	effective	JJ
cord-022313-2675sjlf	293	33	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	293	34	in	in	IN
cord-022313-2675sjlf	293	35	cell	cell	NN
cord-022313-2675sjlf	293	36	culture	culture	NN
cord-022313-2675sjlf	293	37	systems	system	NNS
cord-022313-2675sjlf	293	38	than	than	IN
cord-022313-2675sjlf	293	39	those	those	DT
cord-022313-2675sjlf	293	40	with	with	IN
cord-022313-2675sjlf	293	41	shorter	short	JJR
cord-022313-2675sjlf	293	42	chain	chain	NN
cord-022313-2675sjlf	293	43	fatty	fatty	JJ
cord-022313-2675sjlf	293	44	acids	acid	NNS
cord-022313-2675sjlf	293	45	.	.	.
cord-022313-2675sjlf	294	1	In	in	IN
cord-022313-2675sjlf	294	2	addition	addition	NN
cord-022313-2675sjlf	294	3	,	,	,
cord-022313-2675sjlf	294	4	studies	study	NNS
cord-022313-2675sjlf	294	5	with	with	IN
cord-022313-2675sjlf	294	6	cell	cell	NN
cord-022313-2675sjlf	294	7	-	-	HYPH
cord-022313-2675sjlf	294	8	free	free	JJ
cord-022313-2675sjlf	294	9	extracts	extract	NNS
cord-022313-2675sjlf	294	10	or	or	CC
cord-022313-2675sjlf	294	11	partially	partially	RB
cord-022313-2675sjlf	294	12	purified	purify	VBN
cord-022313-2675sjlf	294	13	GlcNAc-1-Ρ	GlcNAc-1-Ρ	NNP
cord-022313-2675sjlf	294	14	transferase	transferase	NN
cord-022313-2675sjlf	294	15	preparations	preparation	NNS
cord-022313-2675sjlf	294	16	showed	show	VBD
cord-022313-2675sjlf	294	17	that	that	IN
cord-022313-2675sjlf	294	18	the	the	DT
cord-022313-2675sjlf	294	19	streptoviridins	streptoviridin	NNS
cord-022313-2675sjlf	294	20	had	have	VBD
cord-022313-2675sjlf	294	21	a	a	DT
cord-022313-2675sjlf	294	22	lower	low	JJR
cord-022313-2675sjlf	294	23	affinity	affinity	NN
cord-022313-2675sjlf	294	24	for	for	IN
cord-022313-2675sjlf	294	25	the	the	DT
cord-022313-2675sjlf	294	26	enzyme	enzyme	NN
cord-022313-2675sjlf	294	27	than	than	IN
cord-022313-2675sjlf	294	28	did	do	VBD
cord-022313-2675sjlf	294	29	the	the	DT
cord-022313-2675sjlf	294	30	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	294	31	complex	complex	NN
cord-022313-2675sjlf	294	32	(	(	-LRB-
cord-022313-2675sjlf	294	33	115	115	CD
cord-022313-2675sjlf	294	34	)	)	-RRB-
cord-022313-2675sjlf	294	35	.	.	.
cord-022313-2675sjlf	295	1	In	in	IN
cord-022313-2675sjlf	295	2	fact	fact	NN
cord-022313-2675sjlf	295	3	,	,	,
cord-022313-2675sjlf	295	4	with	with	IN
cord-022313-2675sjlf	295	5	this	this	DT
cord-022313-2675sjlf	295	6	inhibitor	inhibitor	NN
cord-022313-2675sjlf	295	7	it	-PRON-	PRP
cord-022313-2675sjlf	295	8	was	be	VBD
cord-022313-2675sjlf	295	9	possible	possible	JJ
cord-022313-2675sjlf	295	10	to	to	TO
cord-022313-2675sjlf	295	11	demonstrate	demonstrate	VB
cord-022313-2675sjlf	295	12	competi	competi	NN
cord-022313-2675sjlf	295	13	tive	tive	JJ
cord-022313-2675sjlf	295	14	inhibition	inhibition	NN
cord-022313-2675sjlf	295	15	with	with	IN
cord-022313-2675sjlf	295	16	regard	regard	NN
cord-022313-2675sjlf	295	17	to	to	IN
cord-022313-2675sjlf	295	18	UDP	UDP	NNP
cord-022313-2675sjlf	295	19	-	-	HYPH
cord-022313-2675sjlf	295	20	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	295	21	,	,	,
cord-022313-2675sjlf	295	22	because	because	IN
cord-022313-2675sjlf	295	23	the	the	DT
cord-022313-2675sjlf	295	24	affinity	affinity	NN
cord-022313-2675sjlf	295	25	of	of	IN
cord-022313-2675sjlf	295	26	the	the	DT
cord-022313-2675sjlf	295	27	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	295	28	-	-	HYPH
cord-022313-2675sjlf	295	29	l	l	NN
cord-022313-2675sjlf	295	30	-	-	HYPH
cord-022313-2675sjlf	295	31	P	p	NN
cord-022313-2675sjlf	295	32	transferase	transferase	NN
cord-022313-2675sjlf	295	33	for	for	IN
cord-022313-2675sjlf	295	34	streptoviridin	streptoviridin	NNS
cord-022313-2675sjlf	295	35	was	be	VBD
cord-022313-2675sjlf	295	36	considerably	considerably	RB
cord-022313-2675sjlf	295	37	lower	low	JJR
cord-022313-2675sjlf	295	38	than	than	IN
cord-022313-2675sjlf	295	39	that	that	DT
cord-022313-2675sjlf	295	40	for	for	IN
cord-022313-2675sjlf	295	41	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	295	42	.	.	.
cord-022313-2675sjlf	296	1	A	a	DT
cord-022313-2675sjlf	296	2	number	number	NN
cord-022313-2675sjlf	296	3	of	of	IN
cord-022313-2675sjlf	296	4	other	other	JJ
cord-022313-2675sjlf	296	5	antibiotics	antibiotic	NNS
cord-022313-2675sjlf	296	6	and	and	CC
cord-022313-2675sjlf	296	7	other	other	JJ
cord-022313-2675sjlf	296	8	compounds	compound	NNS
cord-022313-2675sjlf	296	9	have	have	VBP
cord-022313-2675sjlf	296	10	been	be	VBN
cord-022313-2675sjlf	296	11	found	find	VBN
cord-022313-2675sjlf	296	12	to	to	TO
cord-022313-2675sjlf	296	13	be	be	VB
cord-022313-2675sjlf	296	14	useful	useful	JJ
cord-022313-2675sjlf	296	15	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	296	16	of	of	IN
cord-022313-2675sjlf	296	17	some	some	DT
cord-022313-2675sjlf	296	18	of	of	IN
cord-022313-2675sjlf	296	19	the	the	DT
cord-022313-2675sjlf	296	20	steps	step	NNS
cord-022313-2675sjlf	296	21	in	in	IN
cord-022313-2675sjlf	296	22	the	the	DT
cord-022313-2675sjlf	296	23	lipid	lipid	NN
cord-022313-2675sjlf	296	24	-	-	HYPH
cord-022313-2675sjlf	296	25	linked	link	VBN
cord-022313-2675sjlf	296	26	saccharide	saccharide	NN
cord-022313-2675sjlf	296	27	pathway	pathway	NN
cord-022313-2675sjlf	296	28	.	.	.
cord-022313-2675sjlf	297	1	Many	many	JJ
cord-022313-2675sjlf	297	2	of	of	IN
cord-022313-2675sjlf	297	3	these	these	DT
cord-022313-2675sjlf	297	4	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	297	5	,	,	,
cord-022313-2675sjlf	297	6	especially	especially	RB
cord-022313-2675sjlf	297	7	the	the	DT
cord-022313-2675sjlf	297	8	antibiotics	antibiotic	NNS
cord-022313-2675sjlf	297	9	,	,	,
cord-022313-2675sjlf	297	10	were	be	VBD
cord-022313-2675sjlf	297	11	initially	initially	RB
cord-022313-2675sjlf	297	12	discovered	discover	VBN
cord-022313-2675sjlf	297	13	because	because	IN
cord-022313-2675sjlf	297	14	they	-PRON-	PRP
cord-022313-2675sjlf	297	15	block	block	VBP
cord-022313-2675sjlf	297	16	the	the	DT
cord-022313-2675sjlf	297	17	formation	formation	NN
cord-022313-2675sjlf	297	18	of	of	IN
cord-022313-2675sjlf	297	19	bacterial	bacterial	JJ
cord-022313-2675sjlf	297	20	cell	cell	NN
cord-022313-2675sjlf	297	21	wall	wall	NN
cord-022313-2675sjlf	297	22	polymers	polymer	NNS
cord-022313-2675sjlf	297	23	such	such	JJ
cord-022313-2675sjlf	297	24	as	as	IN
cord-022313-2675sjlf	297	25	peptidoglycan	peptidoglycan	NN
cord-022313-2675sjlf	297	26	or	or	CC
cord-022313-2675sjlf	297	27	lipopolysaccharide	lipopolysaccharide	NN
cord-022313-2675sjlf	297	28	.	.	.
cord-022313-2675sjlf	298	1	Because	because	IN
cord-022313-2675sjlf	298	2	the	the	DT
cord-022313-2675sjlf	298	3	formation	formation	NN
cord-022313-2675sjlf	298	4	of	of	IN
cord-022313-2675sjlf	298	5	these	these	DT
cord-022313-2675sjlf	298	6	polymers	polymer	NNS
cord-022313-2675sjlf	298	7	also	also	RB
cord-022313-2675sjlf	298	8	involves	involve	VBZ
cord-022313-2675sjlf	298	9	polyprenyl	polyprenyl	NN
cord-022313-2675sjlf	298	10	-	-	HYPH
cord-022313-2675sjlf	298	11	linked	link	VBN
cord-022313-2675sjlf	298	12	saccharide	saccharide	NN
cord-022313-2675sjlf	298	13	intermediates	intermediate	NNS
cord-022313-2675sjlf	298	14	,	,	,
cord-022313-2675sjlf	298	15	these	these	DT
cord-022313-2675sjlf	298	16	compounds	compound	NNS
cord-022313-2675sjlf	298	17	appeared	appear	VBD
cord-022313-2675sjlf	298	18	to	to	TO
cord-022313-2675sjlf	298	19	be	be	VB
cord-022313-2675sjlf	298	20	likely	likely	JJ
cord-022313-2675sjlf	298	21	candidates	candidate	NNS
cord-022313-2675sjlf	298	22	to	to	TO
cord-022313-2675sjlf	298	23	test	test	VB
cord-022313-2675sjlf	298	24	on	on	IN
cord-022313-2675sjlf	298	25	the	the	DT
cord-022313-2675sjlf	298	26	N	n	NN
cord-022313-2675sjlf	298	27	-	-	HYPH
cord-022313-2675sjlf	298	28	linked	link	VBN
cord-022313-2675sjlf	298	29	glycosylation	glycosylation	NN
cord-022313-2675sjlf	298	30	pathway	pathway	NN
cord-022313-2675sjlf	298	31	.	.	.
cord-022313-2675sjlf	299	1	For	for	IN
cord-022313-2675sjlf	299	2	example	example	NN
cord-022313-2675sjlf	299	3	,	,	,
cord-022313-2675sjlf	299	4	the	the	DT
cord-022313-2675sjlf	299	5	antibiotics	antibiotic	NNS
cord-022313-2675sjlf	299	6	amphomycin	amphomycin	NNS
cord-022313-2675sjlf	299	7	and	and	CC
cord-022313-2675sjlf	299	8	tsushimycin	tsushimycin	NNS
cord-022313-2675sjlf	299	9	inhibit	inhibit	VBP
cord-022313-2675sjlf	299	10	the	the	DT
cord-022313-2675sjlf	299	11	transferase	transferase	NN
cord-022313-2675sjlf	299	12	that	that	WDT
cord-022313-2675sjlf	299	13	adds	add	VBZ
cord-022313-2675sjlf	299	14	phospho	phospho	NN
cord-022313-2675sjlf	299	15	-	-	HYPH
cord-022313-2675sjlf	299	16	N	N	NNP
cord-022313-2675sjlf	299	17	-	-	HYPH
cord-022313-2675sjlf	299	18	acetylmuramoyl	acetylmuramoyl	NNP
cord-022313-2675sjlf	299	19	-	-	HYPH
cord-022313-2675sjlf	299	20	pentapeptide	pentapeptide	NN
cord-022313-2675sjlf	299	21	to	to	IN
cord-022313-2675sjlf	299	22	the	the	DT
cord-022313-2675sjlf	299	23	growing	grow	VBG
cord-022313-2675sjlf	299	24	peptidoglycan	peptidoglycan	NN
cord-022313-2675sjlf	299	25	chains	chain	NNS
cord-022313-2675sjlf	299	26	(	(	-LRB-
cord-022313-2675sjlf	299	27	137	137	CD
cord-022313-2675sjlf	299	28	)	)	-RRB-
cord-022313-2675sjlf	299	29	,	,	,
cord-022313-2675sjlf	299	30	whereas	whereas	IN
cord-022313-2675sjlf	299	31	bacitracin	bacitracin	NN
cord-022313-2675sjlf	299	32	inhibits	inhibit	VBZ
cord-022313-2675sjlf	299	33	the	the	DT
cord-022313-2675sjlf	299	34	enzyme	enzyme	NN
cord-022313-2675sjlf	299	35	that	that	WDT
cord-022313-2675sjlf	299	36	catalyzes	catalyze	VBZ
cord-022313-2675sjlf	299	37	the	the	DT
cord-022313-2675sjlf	299	38	dephosphorylation	dephosphorylation	NN
cord-022313-2675sjlf	299	39	of	of	IN
cord-022313-2675sjlf	299	40	undecaprenyl	undecaprenyl	NN
cord-022313-2675sjlf	299	41	-	-	HYPH
cord-022313-2675sjlf	299	42	pyrophosphate	pyrophosphate	NN
cord-022313-2675sjlf	299	43	(	(	-LRB-
cord-022313-2675sjlf	299	44	138	138	CD
cord-022313-2675sjlf	299	45	)	)	-RRB-
cord-022313-2675sjlf	299	46	,	,	,
cord-022313-2675sjlf	299	47	the	the	DT
cord-022313-2675sjlf	299	48	car	car	NN
cord-022313-2675sjlf	299	49	rier	rier	NN
cord-022313-2675sjlf	299	50	lipid	lipid	NN
cord-022313-2675sjlf	299	51	in	in	IN
cord-022313-2675sjlf	299	52	cell	cell	NN
cord-022313-2675sjlf	299	53	wall	wall	NN
cord-022313-2675sjlf	299	54	biosynthesis	biosynthesis	NNP
cord-022313-2675sjlf	299	55	.	.	.
cord-022313-2675sjlf	300	1	These	these	DT
cord-022313-2675sjlf	300	2	antibiotics	antibiotic	NNS
cord-022313-2675sjlf	300	3	also	also	RB
cord-022313-2675sjlf	300	4	inhibit	inhibit	VBP
cord-022313-2675sjlf	300	5	the	the	DT
cord-022313-2675sjlf	300	6	formation	formation	NN
cord-022313-2675sjlf	300	7	of	of	IN
cord-022313-2675sjlf	300	8	N	n	NN
cord-022313-2675sjlf	300	9	-	-	HYPH
cord-022313-2675sjlf	300	10	linked	link	VBN
cord-022313-2675sjlf	300	11	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	300	12	assembly	assembly	NN
cord-022313-2675sjlf	300	13	as	as	IN
cord-022313-2675sjlf	300	14	discussed	discuss	VBN
cord-022313-2675sjlf	300	15	later	later	RB
cord-022313-2675sjlf	300	16	.	.	.
cord-022313-2675sjlf	301	1	Amphomycin	Amphomycin	NNP
cord-022313-2675sjlf	301	2	is	be	VBZ
cord-022313-2675sjlf	301	3	a	a	DT
cord-022313-2675sjlf	301	4	hydrophobic	hydrophobic	JJ
cord-022313-2675sjlf	301	5	undecapeptide	undecapeptide	NN
cord-022313-2675sjlf	301	6	containing	contain	VBG
cord-022313-2675sjlf	301	7	either	either	CC
cord-022313-2675sjlf	301	8	3isododecanoic	3isododecanoic	CD
cord-022313-2675sjlf	301	9	or	or	CC
cord-022313-2675sjlf	301	10	3-anteisododecanoic	3-anteisododecanoic	CD
cord-022313-2675sjlf	301	11	acids	acid	NNS
cord-022313-2675sjlf	301	12	attached	attach	VBN
cord-022313-2675sjlf	301	13	to	to	IN
cord-022313-2675sjlf	301	14	the	the	DT
cord-022313-2675sjlf	301	15	N	n	CD
cord-022313-2675sjlf	301	16	-	-	HYPH
cord-022313-2675sjlf	301	17	terminal	terminal	JJ
cord-022313-2675sjlf	301	18	aspartic	aspartic	JJ
cord-022313-2675sjlf	301	19	acid	acid	NN
cord-022313-2675sjlf	301	20	in	in	IN
cord-022313-2675sjlf	301	21	an	an	DT
cord-022313-2675sjlf	301	22	amide	amide	NN
cord-022313-2675sjlf	301	23	linkage	linkage	NN
cord-022313-2675sjlf	301	24	(	(	-LRB-
cord-022313-2675sjlf	301	25	139	139	CD
cord-022313-2675sjlf	301	26	)	)	-RRB-
cord-022313-2675sjlf	301	27	.	.	.
cord-022313-2675sjlf	302	1	The	the	DT
cord-022313-2675sjlf	302	2	structure	structure	NN
cord-022313-2675sjlf	302	3	of	of	IN
cord-022313-2675sjlf	302	4	amphomycin	amphomycin	NNS
cord-022313-2675sjlf	302	5	is	be	VBZ
cord-022313-2675sjlf	302	6	presented	present	VBN
cord-022313-2675sjlf	302	7	in	in	IN
cord-022313-2675sjlf	302	8	Fig	Fig	NNP
cord-022313-2675sjlf	302	9	.	.	.
cord-022313-2675sjlf	303	1	7A	7A	NNP
cord-022313-2675sjlf	303	2	.	.	.
cord-022313-2675sjlf	304	1	In	in	IN
cord-022313-2675sjlf	304	2	cell	cell	NN
cord-022313-2675sjlf	304	3	-	-	HYPH
cord-022313-2675sjlf	304	4	free	free	JJ
cord-022313-2675sjlf	304	5	extracts	extract	NNS
cord-022313-2675sjlf	304	6	of	of	IN
cord-022313-2675sjlf	304	7	aorta	aorta	JJ
cord-022313-2675sjlf	304	8	tissue	tissue	NN
cord-022313-2675sjlf	304	9	,	,	,
cord-022313-2675sjlf	304	10	amphomycin	amphomycin	NNS
cord-022313-2675sjlf	304	11	blocked	block	VBD
cord-022313-2675sjlf	304	12	the	the	DT
cord-022313-2675sjlf	304	13	formation	formation	NN
cord-022313-2675sjlf	304	14	of	of	IN
cord-022313-2675sjlf	304	15	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	304	16	-	-	HYPH
cord-022313-2675sjlf	304	17	P	p	NN
cord-022313-2675sjlf	304	18	-	-	HYPH
cord-022313-2675sjlf	304	19	mannose	mannose	NN
cord-022313-2675sjlf	304	20	from	from	IN
cord-022313-2675sjlf	304	21	GDP	gdp	NN
cord-022313-2675sjlf	304	22	-	-	HYPH
cord-022313-2675sjlf	304	23	mannose	mannose	NN
cord-022313-2675sjlf	304	24	,	,	,
cord-022313-2675sjlf	304	25	but	but	CC
cord-022313-2675sjlf	304	26	it	-PRON-	PRP
cord-022313-2675sjlf	304	27	did	do	VBD
cord-022313-2675sjlf	304	28	not	not	RB
cord-022313-2675sjlf	304	29	affect	affect	VB
cord-022313-2675sjlf	304	30	the	the	DT
cord-022313-2675sjlf	304	31	transfer	transfer	NN
cord-022313-2675sjlf	304	32	of	of	IN
cord-022313-2675sjlf	304	33	mannose	mannose	NN
cord-022313-2675sjlf	304	34	to	to	IN
cord-022313-2675sjlf	304	35	lipid	lipid	NN
cord-022313-2675sjlf	304	36	-	-	HYPH
cord-022313-2675sjlf	304	37	linked	link	VBN
cord-022313-2675sjlf	304	38	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	304	39	from	from	IN
cord-022313-2675sjlf	304	40	either	either	CC
cord-022313-2675sjlf	304	41	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	304	42	-	-	HYPH
cord-022313-2675sjlf	304	43	P	p	NN
cord-022313-2675sjlf	304	44	-	-	HYPH
cord-022313-2675sjlf	304	45	mannose	mannose	NN
cord-022313-2675sjlf	304	46	or	or	CC
cord-022313-2675sjlf	304	47	GDP	gdp	NN
cord-022313-2675sjlf	304	48	-	-	HYPH
cord-022313-2675sjlf	304	49	mannose	mannose	NN
cord-022313-2675sjlf	304	50	(	(	-LRB-
cord-022313-2675sjlf	304	51	37	37	CD
cord-022313-2675sjlf	304	52	,	,	,
cord-022313-2675sjlf	304	53	38	38	CD
cord-022313-2675sjlf	304	54	)	)	-RRB-
cord-022313-2675sjlf	304	55	.	.	.
cord-022313-2675sjlf	305	1	Thus	thus	RB
cord-022313-2675sjlf	305	2	,	,	,
cord-022313-2675sjlf	305	3	when	when	WRB
cord-022313-2675sjlf	305	4	microsomes	microsomes	NNP
cord-022313-2675sjlf	305	5	were	be	VBD
cord-022313-2675sjlf	305	6	incubated	incubate	VBN
cord-022313-2675sjlf	305	7	with	with	IN
cord-022313-2675sjlf	305	8	GDP-	GDP-	NNS
cord-022313-2675sjlf	305	9	[	[	-LRB-
cord-022313-2675sjlf	305	10	14	14	CD
cord-022313-2675sjlf	305	11	C]mannose	C]mannose	NNPS
cord-022313-2675sjlf	305	12	in	in	IN
cord-022313-2675sjlf	305	13	the	the	DT
cord-022313-2675sjlf	305	14	presence	presence	NN
cord-022313-2675sjlf	305	15	of	of	IN
cord-022313-2675sjlf	305	16	enough	enough	JJ
cord-022313-2675sjlf	305	17	amphomycin	amphomycin	NNS
cord-022313-2675sjlf	305	18	to	to	TO
cord-022313-2675sjlf	305	19	completely	completely	RB
cord-022313-2675sjlf	305	20	inhibit	inhibit	VB
cord-022313-2675sjlf	305	21	the	the	DT
cord-022313-2675sjlf	305	22	formation	formation	NN
cord-022313-2675sjlf	305	23	of	of	IN
cord-022313-2675sjlf	305	24	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	305	25	-	-	HYPH
cord-022313-2675sjlf	305	26	P-	P-	NNP
cord-022313-2675sjlf	305	27	[	[	-LRB-
cord-022313-2675sjlf	305	28	14	14	CD
cord-022313-2675sjlf	305	29	C]mannose	C]mannose	NNP
cord-022313-2675sjlf	305	30	,	,	,
cord-022313-2675sjlf	305	31	these	these	DT
cord-022313-2675sjlf	305	32	extracts	extract	NNS
cord-022313-2675sjlf	305	33	accumulated	accumulate	VBN
cord-022313-2675sjlf	305	34	14	14	CD
cord-022313-2675sjlf	305	35	C	C	NNP
cord-022313-2675sjlf	305	36	-	-	HYPH
cord-022313-2675sjlf	305	37	Man	Man	NNP
cord-022313-2675sjlf	305	38	5	5	CD
cord-022313-2675sjlf	305	39	(	(	-LRB-
cord-022313-2675sjlf	305	40	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	305	41	)	)	-RRB-
cord-022313-2675sjlf	305	42	2	2	CD
cord-022313-2675sjlf	305	43	-PPdolichol	-ppdolichol	XX
cord-022313-2675sjlf	305	44	,	,	,
cord-022313-2675sjlf	305	45	but	but	CC
cord-022313-2675sjlf	305	46	they	-PRON-	PRP
cord-022313-2675sjlf	305	47	were	be	VBD
cord-022313-2675sjlf	305	48	not	not	RB
cord-022313-2675sjlf	305	49	able	able	JJ
cord-022313-2675sjlf	305	50	to	to	TO
cord-022313-2675sjlf	305	51	elongate	elongate	VB
cord-022313-2675sjlf	305	52	this	this	DT
cord-022313-2675sjlf	305	53	lipid	lipid	NN
cord-022313-2675sjlf	305	54	to	to	IN
cord-022313-2675sjlf	305	55	larger	large	JJR
cord-022313-2675sjlf	305	56	sized	sized	JJ
cord-022313-2675sjlf	305	57	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	305	58	-	-	HYPH
cord-022313-2675sjlf	305	59	lipids	lipid	NNS
cord-022313-2675sjlf	305	60	.	.	.
cord-022313-2675sjlf	306	1	On	on	IN
cord-022313-2675sjlf	306	2	the	the	DT
cord-022313-2675sjlf	306	3	other	other	JJ
cord-022313-2675sjlf	306	4	hand	hand	NN
cord-022313-2675sjlf	306	5	,	,	,
cord-022313-2675sjlf	306	6	when	when	WRB
cord-022313-2675sjlf	306	7	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	306	8	-	-	HYPH
cord-022313-2675sjlf	306	9	P-	P-	NNP
cord-022313-2675sjlf	306	10	[	[	-LRB-
cord-022313-2675sjlf	306	11	14	14	CD
cord-022313-2675sjlf	306	12	C]mannose	C]mannose	NNP
cord-022313-2675sjlf	306	13	was	be	VBD
cord-022313-2675sjlf	306	14	used	use	VBN
cord-022313-2675sjlf	306	15	as	as	IN
cord-022313-2675sjlf	306	16	the	the	DT
cord-022313-2675sjlf	306	17	substrate	substrate	NN
cord-022313-2675sjlf	306	18	with	with	IN
cord-022313-2675sjlf	306	19	these	these	DT
cord-022313-2675sjlf	306	20	extracts	extract	NNS
cord-022313-2675sjlf	306	21	,	,	,
cord-022313-2675sjlf	306	22	mannose	mannose	NN
cord-022313-2675sjlf	306	23	was	be	VBD
cord-022313-2675sjlf	306	24	transferred	transfer	VBN
cord-022313-2675sjlf	306	25	to	to	IN
cord-022313-2675sjlf	306	26	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	306	27	-	-	HYPH
cord-022313-2675sjlf	306	28	lipids	lipid	NNS
cord-022313-2675sjlf	306	29	that	that	WDT
cord-022313-2675sjlf	306	30	contained	contain	VBD
cord-022313-2675sjlf	306	31	six	six	CD
cord-022313-2675sjlf	306	32	or	or	CC
cord-022313-2675sjlf	306	33	more	more	JJR
cord-022313-2675sjlf	306	34	mannose	mannose	JJ
cord-022313-2675sjlf	306	35	residues	residue	NNS
cord-022313-2675sjlf	306	36	.	.	.
cord-022313-2675sjlf	307	1	These	these	DT
cord-022313-2675sjlf	307	2	studies	study	NNS
cord-022313-2675sjlf	307	3	suggested	suggest	VBD
cord-022313-2675sjlf	307	4	that	that	IN
cord-022313-2675sjlf	307	5	the	the	DT
cord-022313-2675sjlf	307	6	first	first	JJ
cord-022313-2675sjlf	307	7	five	five	CD
cord-022313-2675sjlf	307	8	mannose	mannose	NN
cord-022313-2675sjlf	307	9	residues	residue	NNS
cord-022313-2675sjlf	307	10	in	in	IN
cord-022313-2675sjlf	307	11	the	the	DT
cord-022313-2675sjlf	307	12	lipid	lipid	NN
cord-022313-2675sjlf	307	13	-	-	HYPH
cord-022313-2675sjlf	307	14	linked	link	VBN
cord-022313-2675sjlf	307	15	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	307	16	were	be	VBD
cord-022313-2675sjlf	307	17	donated	donate	VBN
cord-022313-2675sjlf	307	18	from	from	IN
cord-022313-2675sjlf	307	19	GDP	gdp	NN
cord-022313-2675sjlf	307	20	-	-	HYPH
cord-022313-2675sjlf	307	21	mannose	mannose	NN
cord-022313-2675sjlf	307	22	,	,	,
cord-022313-2675sjlf	307	23	whereas	whereas	IN
cord-022313-2675sjlf	307	24	the	the	DT
cord-022313-2675sjlf	307	25	next	next	JJ
cord-022313-2675sjlf	307	26	four	four	CD
cord-022313-2675sjlf	307	27	mannoses	mannose	NNS
cord-022313-2675sjlf	307	28	came	come	VBD
cord-022313-2675sjlf	307	29	from	from	IN
cord-022313-2675sjlf	307	30	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	307	31	-	-	HYPH
cord-022313-2675sjlf	307	32	P	p	NN
cord-022313-2675sjlf	307	33	-	-	HYPH
cord-022313-2675sjlf	307	34	mannose	mannose	NN
cord-022313-2675sjlf	307	35	(	(	-LRB-
cord-022313-2675sjlf	307	36	37	37	CD
cord-022313-2675sjlf	307	37	)	)	-RRB-
cord-022313-2675sjlf	307	38	.	.	.
cord-022313-2675sjlf	308	1	Similar	similar	JJ
cord-022313-2675sjlf	308	2	results	result	NNS
cord-022313-2675sjlf	308	3	were	be	VBD
cord-022313-2675sjlf	308	4	obtained	obtain	VBN
cord-022313-2675sjlf	308	5	with	with	IN
cord-022313-2675sjlf	308	6	oviduct	oviduct	NN
cord-022313-2675sjlf	308	7	tissue	tissue	NN
cord-022313-2675sjlf	308	8	(	(	-LRB-
cord-022313-2675sjlf	308	9	140	140	CD
cord-022313-2675sjlf	308	10	)	)	-RRB-
cord-022313-2675sjlf	308	11	and	and	CC
cord-022313-2675sjlf	308	12	embryonic	embryonic	JJ
cord-022313-2675sjlf	308	13	liver	liver	NN
cord-022313-2675sjlf	308	14	(	(	-LRB-
cord-022313-2675sjlf	308	15	141	141	CD
cord-022313-2675sjlf	308	16	)	)	-RRB-
cord-022313-2675sjlf	308	17	.	.	.
cord-022313-2675sjlf	309	1	The	the	DT
cord-022313-2675sjlf	309	2	isolation	isolation	NN
cord-022313-2675sjlf	309	3	of	of	IN
cord-022313-2675sjlf	309	4	a	a	DT
cord-022313-2675sjlf	309	5	CHO	CHO	NNP
cord-022313-2675sjlf	309	6	mutant	mutant	JJ
cord-022313-2675sjlf	309	7	cell	cell	NN
cord-022313-2675sjlf	309	8	line	line	NN
cord-022313-2675sjlf	309	9	missing	miss	VBG
cord-022313-2675sjlf	309	10	the	the	DT
cord-022313-2675sjlf	309	11	dolichyl	dolichyl	NN
cord-022313-2675sjlf	309	12	-	-	HYPH
cord-022313-2675sjlf	309	13	P	p	NN
cord-022313-2675sjlf	309	14	-	-	HYPH
cord-022313-2675sjlf	309	15	mannose	mannose	NN
cord-022313-2675sjlf	309	16	synthase	synthase	NN
cord-022313-2675sjlf	309	17	clearly	clearly	RB
cord-022313-2675sjlf	309	18	established	establish	VBD
cord-022313-2675sjlf	309	19	that	that	IN
cord-022313-2675sjlf	309	20	doli-	doli-	NN
cord-022313-2675sjlf	309	21	chyl	chyl	NN
cord-022313-2675sjlf	309	22	-	-	HYPH
cord-022313-2675sjlf	309	23	P	p	NN
cord-022313-2675sjlf	309	24	-	-	HYPH
cord-022313-2675sjlf	309	25	mannose	mannose	NN
cord-022313-2675sjlf	309	26	was	be	VBD
cord-022313-2675sjlf	309	27	the	the	DT
cord-022313-2675sjlf	309	28	mannosyl	mannosyl	NNP
cord-022313-2675sjlf	309	29	donor	donor	NN
cord-022313-2675sjlf	309	30	for	for	IN
cord-022313-2675sjlf	309	31	the	the	DT
cord-022313-2675sjlf	309	32	last	last	JJ
cord-022313-2675sjlf	309	33	four	four	CD
cord-022313-2675sjlf	309	34	mannose	mannose	NN
cord-022313-2675sjlf	309	35	residues	residue	NNS
cord-022313-2675sjlf	309	36	(	(	-LRB-
cord-022313-2675sjlf	309	37	36	36	CD
cord-022313-2675sjlf	309	38	)	)	-RRB-
cord-022313-2675sjlf	309	39	.	.	.
cord-022313-2675sjlf	310	1	In	in	IN
cord-022313-2675sjlf	310	2	cell	cell	NN
cord-022313-2675sjlf	310	3	-	-	HYPH
cord-022313-2675sjlf	310	4	free	free	JJ
cord-022313-2675sjlf	310	5	extracts	extract	NNS
cord-022313-2675sjlf	310	6	of	of	IN
cord-022313-2675sjlf	310	7	brain	brain	NN
cord-022313-2675sjlf	310	8	tissue	tissue	NN
cord-022313-2675sjlf	310	9	,	,	,
cord-022313-2675sjlf	310	10	amphomycin	amphomycin	NNS
cord-022313-2675sjlf	310	11	inhibited	inhibit	VBD
cord-022313-2675sjlf	310	12	the	the	DT
cord-022313-2675sjlf	310	13	pro	pro	JJ
cord-022313-2675sjlf	310	14	duction	duction	NN
cord-022313-2675sjlf	310	15	of	of	IN
cord-022313-2675sjlf	310	16	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	310	17	-	-	HYPH
cord-022313-2675sjlf	310	18	P	p	NN
cord-022313-2675sjlf	310	19	-	-	HYPH
cord-022313-2675sjlf	310	20	glucose	glucose	NN
cord-022313-2675sjlf	310	21	,	,	,
cord-022313-2675sjlf	310	22	dolichyl	dolichyl	NN
cord-022313-2675sjlf	310	23	-	-	HYPH
cord-022313-2675sjlf	310	24	P	p	NN
cord-022313-2675sjlf	310	25	-	-	HYPH
cord-022313-2675sjlf	310	26	mannose	mannose	NN
cord-022313-2675sjlf	310	27	,	,	,
cord-022313-2675sjlf	310	28	and	and	CC
cord-022313-2675sjlf	310	29	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	310	30	-	-	HYPH
cord-022313-2675sjlf	310	31	PP	PP	NNP
cord-022313-2675sjlf	310	32	-	-	HYPH
cord-022313-2675sjlf	310	33	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	310	34	,	,	,
cord-022313-2675sjlf	310	35	leading	lead	VBG
cord-022313-2675sjlf	310	36	these	these	DT
cord-022313-2675sjlf	310	37	investigators	investigator	NNS
cord-022313-2675sjlf	310	38	to	to	TO
cord-022313-2675sjlf	310	39	suggest	suggest	VB
cord-022313-2675sjlf	310	40	that	that	IN
cord-022313-2675sjlf	310	41	amphomycin	amphomycin	NNS
cord-022313-2675sjlf	310	42	might	may	MD
cord-022313-2675sjlf	310	43	form	form	VB
cord-022313-2675sjlf	310	44	a	a	DT
cord-022313-2675sjlf	310	45	complex	complex	NN
cord-022313-2675sjlf	310	46	with	with	IN
cord-022313-2675sjlf	310	47	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	310	48	-	-	HYPH
cord-022313-2675sjlf	310	49	P	p	NN
cord-022313-2675sjlf	310	50	and	and	CC
cord-022313-2675sjlf	310	51	dolichyl	dolichyl	NN
cord-022313-2675sjlf	310	52	-	-	HYPH
cord-022313-2675sjlf	310	53	P	p	NN
cord-022313-2675sjlf	310	54	derivatives	derivative	NNS
cord-022313-2675sjlf	310	55	(	(	-LRB-
cord-022313-2675sjlf	310	56	142	142	CD
cord-022313-2675sjlf	310	57	)	)	-RRB-
cord-022313-2675sjlf	310	58	.	.	.
cord-022313-2675sjlf	311	1	Some	some	DT
cord-022313-2675sjlf	311	2	evidence	evidence	NN
cord-022313-2675sjlf	311	3	for	for	IN
cord-022313-2675sjlf	311	4	such	such	PDT
cord-022313-2675sjlf	311	5	a	a	DT
cord-022313-2675sjlf	311	6	complex	complex	NN
cord-022313-2675sjlf	311	7	between	between	IN
cord-022313-2675sjlf	311	8	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	311	9	-	-	HYPH
cord-022313-2675sjlf	311	10	P	p	NN
cord-022313-2675sjlf	311	11	and	and	CC
cord-022313-2675sjlf	311	12	amphomycin	amphomycin	NNS
cord-022313-2675sjlf	311	13	has	have	VBZ
cord-022313-2675sjlf	311	14	been	be	VBN
cord-022313-2675sjlf	311	15	obtained	obtain	VBN
cord-022313-2675sjlf	311	16	,	,	,
cord-022313-2675sjlf	311	17	although	although	IN
cord-022313-2675sjlf	311	18	it	-PRON-	PRP
cord-022313-2675sjlf	311	19	is	be	VBZ
cord-022313-2675sjlf	311	20	not	not	RB
cord-022313-2675sjlf	311	21	clear	clear	JJ
cord-022313-2675sjlf	311	22	how	how	WRB
cord-022313-2675sjlf	311	23	this	this	DT
cord-022313-2675sjlf	311	24	relates	relate	VBZ
cord-022313-2675sjlf	311	25	to	to	IN
cord-022313-2675sjlf	311	26	the	the	DT
cord-022313-2675sjlf	311	27	inhibition	inhibition	NN
cord-022313-2675sjlf	311	28	of	of	IN
cord-022313-2675sjlf	311	29	lipid	lipid	NN
cord-022313-2675sjlf	311	30	-	-	HYPH
cord-022313-2675sjlf	311	31	linked	link	VBN
cord-022313-2675sjlf	311	32	saccharide	saccharide	NN
cord-022313-2675sjlf	311	33	formation	formation	NN
cord-022313-2675sjlf	311	34	.	.	.
cord-022313-2675sjlf	312	1	Amphomycin	Amphomycin	NNP
cord-022313-2675sjlf	312	2	has	have	VBZ
cord-022313-2675sjlf	312	3	also	also	RB
cord-022313-2675sjlf	312	4	been	be	VBN
cord-022313-2675sjlf	312	5	used	use	VBN
cord-022313-2675sjlf	312	6	in	in	IN
cord-022313-2675sjlf	312	7	various	various	JJ
cord-022313-2675sjlf	312	8	other	other	JJ
cord-022313-2675sjlf	312	9	experiments	experiment	NNS
cord-022313-2675sjlf	312	10	,	,	,
cord-022313-2675sjlf	312	11	such	such	JJ
cord-022313-2675sjlf	312	12	as	as	IN
cord-022313-2675sjlf	312	13	one	one	CD
cord-022313-2675sjlf	312	14	study	study	NN
cord-022313-2675sjlf	312	15	that	that	WDT
cord-022313-2675sjlf	312	16	demonstrated	demonstrate	VBD
cord-022313-2675sjlf	312	17	that	that	IN
cord-022313-2675sjlf	312	18	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	312	19	-	-	HYPH
cord-022313-2675sjlf	312	20	P	P	NNP
cord-022313-2675sjlf	312	21	was	be	VBD
cord-022313-2675sjlf	312	22	involved	involve	VBN
cord-022313-2675sjlf	312	23	in	in	IN
cord-022313-2675sjlf	312	24	sugar	sugar	NN
cord-022313-2675sjlf	312	25	translocation	translocation	NN
cord-022313-2675sjlf	312	26	across	across	IN
cord-022313-2675sjlf	312	27	the	the	DT
cord-022313-2675sjlf	312	28	ER	ER	NNP
cord-022313-2675sjlf	312	29	membrane	membrane	NN
cord-022313-2675sjlf	312	30	(	(	-LRB-
cord-022313-2675sjlf	312	31	143	143	CD
cord-022313-2675sjlf	312	32	)	)	-RRB-
cord-022313-2675sjlf	312	33	,	,	,
cord-022313-2675sjlf	312	34	and	and	CC
cord-022313-2675sjlf	312	35	in	in	IN
cord-022313-2675sjlf	312	36	one	one	CD
cord-022313-2675sjlf	312	37	case	case	NN
cord-022313-2675sjlf	312	38	to	to	TO
cord-022313-2675sjlf	312	39	show	show	VB
cord-022313-2675sjlf	312	40	that	that	IN
cord-022313-2675sjlf	312	41	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	312	42	-	-	HYPH
cord-022313-2675sjlf	312	43	P	p	NN
cord-022313-2675sjlf	312	44	-	-	HYPH
cord-022313-2675sjlf	312	45	mannose	mannose	NN
cord-022313-2675sjlf	312	46	,	,	,
cord-022313-2675sjlf	312	47	rather	rather	RB
cord-022313-2675sjlf	312	48	than	than	IN
cord-022313-2675sjlf	312	49	GDP	gdp	NN
cord-022313-2675sjlf	312	50	-	-	HYPH
cord-022313-2675sjlf	312	51	mannose	mannose	NN
cord-022313-2675sjlf	312	52	,	,	,
cord-022313-2675sjlf	312	53	was	be	VBD
cord-022313-2675sjlf	312	54	involved	involve	VBN
cord-022313-2675sjlf	312	55	in	in	IN
cord-022313-2675sjlf	312	56	the	the	DT
cord-022313-2675sjlf	312	57	elongation	elongation	NN
cord-022313-2675sjlf	312	58	of	of	IN
cord-022313-2675sjlf	312	59	Man	Man	NNP
cord-022313-2675sjlf	312	60	7	7	CD
cord-022313-2675sjlf	312	61	(	(	-LRB-
cord-022313-2675sjlf	312	62	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	312	63	)	)	-RRB-
cord-022313-2675sjlf	312	64	2	2	CD
cord-022313-2675sjlf	312	65	-PPdolichol	-PPdolichol	:
cord-022313-2675sjlf	312	66	(	(	-LRB-
cord-022313-2675sjlf	312	67	144	144	CD
cord-022313-2675sjlf	312	68	)	)	-RRB-
cord-022313-2675sjlf	312	69	.	.	.
cord-022313-2675sjlf	313	1	Another	another	DT
cord-022313-2675sjlf	313	2	lipopeptide	lipopeptide	NN
cord-022313-2675sjlf	313	3	antibiotic	antibiotic	NN
cord-022313-2675sjlf	313	4	,	,	,
cord-022313-2675sjlf	313	5	called	call	VBN
cord-022313-2675sjlf	313	6	tsushimycin	tsushimycin	NNP
cord-022313-2675sjlf	313	7	,	,	,
cord-022313-2675sjlf	313	8	has	have	VBZ
cord-022313-2675sjlf	313	9	a	a	DT
cord-022313-2675sjlf	313	10	mechanism	mechanism	NN
cord-022313-2675sjlf	313	11	of	of	IN
cord-022313-2675sjlf	313	12	action	action	NN
cord-022313-2675sjlf	313	13	similar	similar	JJ
cord-022313-2675sjlf	313	14	to	to	IN
cord-022313-2675sjlf	313	15	that	that	DT
cord-022313-2675sjlf	313	16	of	of	IN
cord-022313-2675sjlf	313	17	amphomycin	amphomycin	NNS
cord-022313-2675sjlf	313	18	(	(	-LRB-
cord-022313-2675sjlf	313	19	145	145	CD
cord-022313-2675sjlf	313	20	)	)	-RRB-
cord-022313-2675sjlf	313	21	.	.	.
cord-022313-2675sjlf	314	1	Unfortu	Unfortu	NNP
cord-022313-2675sjlf	314	2	nately	nately	RB
cord-022313-2675sjlf	314	3	,	,	,
cord-022313-2675sjlf	314	4	these	these	DT
cord-022313-2675sjlf	314	5	peptide	peptide	NN
cord-022313-2675sjlf	314	6	antibiotics	antibiotic	NNS
cord-022313-2675sjlf	314	7	do	do	VBP
cord-022313-2675sjlf	314	8	not	not	RB
cord-022313-2675sjlf	314	9	appear	appear	VB
cord-022313-2675sjlf	314	10	to	to	TO
cord-022313-2675sjlf	314	11	be	be	VB
cord-022313-2675sjlf	314	12	effective	effective	JJ
cord-022313-2675sjlf	314	13	in	in	IN
cord-022313-2675sjlf	314	14	cell	cell	NN
cord-022313-2675sjlf	314	15	cultures	culture	NNS
cord-022313-2675sjlf	314	16	of	of	IN
cord-022313-2675sjlf	314	17	eucaryotic	eucaryotic	JJ
cord-022313-2675sjlf	314	18	cells	cell	NNS
cord-022313-2675sjlf	314	19	,	,	,
cord-022313-2675sjlf	314	20	probably	probably	RB
cord-022313-2675sjlf	314	21	because	because	IN
cord-022313-2675sjlf	314	22	they	-PRON-	PRP
cord-022313-2675sjlf	314	23	do	do	VBP
cord-022313-2675sjlf	314	24	not	not	RB
cord-022313-2675sjlf	314	25	cross	cross	VB
cord-022313-2675sjlf	314	26	the	the	DT
cord-022313-2675sjlf	314	27	plasma	plasma	NN
cord-022313-2675sjlf	314	28	membrane	membrane	NN
cord-022313-2675sjlf	314	29	.	.	.
cord-022313-2675sjlf	315	1	Bacitracin	Bacitracin	NNP
cord-022313-2675sjlf	315	2	is	be	VBZ
cord-022313-2675sjlf	315	3	another	another	DT
cord-022313-2675sjlf	315	4	lipopeptide	lipopeptide	JJ
cord-022313-2675sjlf	315	5	antibiotic	antibiotic	JJ
cord-022313-2675sjlf	315	6	that	that	WDT
cord-022313-2675sjlf	315	7	has	have	VBZ
cord-022313-2675sjlf	315	8	been	be	VBN
cord-022313-2675sjlf	315	9	useful	useful	JJ
cord-022313-2675sjlf	315	10	in	in	IN
cord-022313-2675sjlf	315	11	studying	study	VBG
cord-022313-2675sjlf	315	12	both	both	DT
cord-022313-2675sjlf	315	13	bacterial	bacterial	JJ
cord-022313-2675sjlf	315	14	cell	cell	NN
cord-022313-2675sjlf	315	15	wall	wall	NN
cord-022313-2675sjlf	315	16	biosynthesis	biosynthesis	NNP
cord-022313-2675sjlf	315	17	and	and	CC
cord-022313-2675sjlf	315	18	the	the	DT
cord-022313-2675sjlf	315	19	synthesis	synthesis	NN
cord-022313-2675sjlf	315	20	of	of	IN
cord-022313-2675sjlf	315	21	lipidlinked	lipidlinked	JJ
cord-022313-2675sjlf	315	22	saccharides	saccharide	NNS
cord-022313-2675sjlf	315	23	.	.	.
cord-022313-2675sjlf	316	1	The	the	DT
cord-022313-2675sjlf	316	2	structure	structure	NN
cord-022313-2675sjlf	316	3	of	of	IN
cord-022313-2675sjlf	316	4	this	this	DT
cord-022313-2675sjlf	316	5	compound	compound	NN
cord-022313-2675sjlf	316	6	is	be	VBZ
cord-022313-2675sjlf	316	7	presented	present	VBN
cord-022313-2675sjlf	316	8	in	in	IN
cord-022313-2675sjlf	316	9	Fig	Fig	NNP
cord-022313-2675sjlf	316	10	.	.	.
cord-022313-2675sjlf	316	11	 	 	_SP
cord-022313-2675sjlf	317	1	7B	7B	NNP
cord-022313-2675sjlf	317	2	.	.	.
cord-022313-2675sjlf	318	1	Bacitracin	Bacitracin	NNP
cord-022313-2675sjlf	318	2	was	be	VBD
cord-022313-2675sjlf	318	3	shown	show	VBN
cord-022313-2675sjlf	318	4	to	to	TO
cord-022313-2675sjlf	318	5	inhibit	inhibit	VB
cord-022313-2675sjlf	318	6	the	the	DT
cord-022313-2675sjlf	318	7	synthesis	synthesis	NN
cord-022313-2675sjlf	318	8	of	of	IN
cord-022313-2675sjlf	318	9	bacterial	bacterial	JJ
cord-022313-2675sjlf	318	10	cell	cell	NN
cord-022313-2675sjlf	318	11	wall	wall	NN
cord-022313-2675sjlf	318	12	peptidoglycan	peptidoglycan	NN
cord-022313-2675sjlf	318	13	by	by	IN
cord-022313-2675sjlf	318	14	inhibiting	inhibit	VBG
cord-022313-2675sjlf	318	15	the	the	DT
cord-022313-2675sjlf	318	16	dephosphorylation	dephosphorylation	NN
cord-022313-2675sjlf	318	17	of	of	IN
cord-022313-2675sjlf	318	18	undecaprenylpyrophosphate	undecaprenylpyrophosphate	NNP
cord-022313-2675sjlf	318	19	,	,	,
cord-022313-2675sjlf	318	20	which	which	WDT
cord-022313-2675sjlf	318	21	is	be	VBZ
cord-022313-2675sjlf	318	22	necessary	necessary	JJ
cord-022313-2675sjlf	318	23	for	for	IN
cord-022313-2675sjlf	318	24	the	the	DT
cord-022313-2675sjlf	318	25	reutilization	reutilization	NN
cord-022313-2675sjlf	318	26	of	of	IN
cord-022313-2675sjlf	318	27	this	this	DT
cord-022313-2675sjlf	318	28	carrier	carrier	NN
cord-022313-2675sjlf	318	29	molecule	molecule	NN
cord-022313-2675sjlf	318	30	(	(	-LRB-
cord-022313-2675sjlf	318	31	138	138	CD
cord-022313-2675sjlf	318	32	)	)	-RRB-
cord-022313-2675sjlf	318	33	.	.	.
cord-022313-2675sjlf	319	1	In	in	IN
cord-022313-2675sjlf	319	2	animal	animal	NN
cord-022313-2675sjlf	319	3	cells	cell	NNS
cord-022313-2675sjlf	319	4	,	,	,
cord-022313-2675sjlf	319	5	the	the	DT
cord-022313-2675sjlf	319	6	specific	specific	JJ
cord-022313-2675sjlf	319	7	site	site	NN
cord-022313-2675sjlf	319	8	of	of	IN
cord-022313-2675sjlf	319	9	inhibition	inhibition	NN
cord-022313-2675sjlf	319	10	by	by	IN
cord-022313-2675sjlf	319	11	this	this	DT
cord-022313-2675sjlf	319	12	antibiotic	antibiotic	NN
cord-022313-2675sjlf	319	13	is	be	VBZ
cord-022313-2675sjlf	319	14	not	not	RB
cord-022313-2675sjlf	319	15	clear	clear	JJ
cord-022313-2675sjlf	319	16	because	because	IN
cord-022313-2675sjlf	319	17	it	-PRON-	PRP
cord-022313-2675sjlf	319	18	has	have	VBZ
cord-022313-2675sjlf	319	19	been	be	VBN
cord-022313-2675sjlf	319	20	reported	report	VBN
cord-022313-2675sjlf	319	21	to	to	TO
cord-022313-2675sjlf	319	22	act	act	VB
cord-022313-2675sjlf	319	23	at	at	IN
cord-022313-2675sjlf	319	24	several	several	JJ
cord-022313-2675sjlf	319	25	different	different	JJ
cord-022313-2675sjlf	319	26	points	point	NNS
cord-022313-2675sjlf	319	27	,	,	,
cord-022313-2675sjlf	319	28	including	include	VBG
cord-022313-2675sjlf	319	29	some	some	DT
cord-022313-2675sjlf	319	30	of	of	IN
cord-022313-2675sjlf	319	31	the	the	DT
cord-022313-2675sjlf	319	32	mannosyltransferases	mannosyltransferase	NNS
cord-022313-2675sjlf	319	33	that	that	WDT
cord-022313-2675sjlf	319	34	add	add	VBP
cord-022313-2675sjlf	319	35	mannose	mannose	NN
cord-022313-2675sjlf	319	36	to	to	IN
cord-022313-2675sjlf	319	37	the	the	DT
cord-022313-2675sjlf	319	38	trisaccharide	trisaccharide	NN
cord-022313-2675sjlf	319	39	-	-	HYPH
cord-022313-2675sjlf	319	40	lipid	lipid	NN
cord-022313-2675sjlf	319	41	Man/3(GlcNAc	Man/3(GlcNAc	NNP
cord-022313-2675sjlf	319	42	)	)	-RRB-
cord-022313-2675sjlf	320	1	2	2	LS
cord-022313-2675sjlf	320	2	-PP	-PP	NNS
cord-022313-2675sjlf	320	3	-	-	HYPH
cord-022313-2675sjlf	320	4	dolichol	dolichol	JJ
cord-022313-2675sjlf	320	5	,	,	,
cord-022313-2675sjlf	320	6	the	the	DT
cord-022313-2675sjlf	320	7	GlcNAc-1-P	glcnac-1-p	JJ
cord-022313-2675sjlf	320	8	transferase	transferase	NN
cord-022313-2675sjlf	320	9	that	that	WDT
cord-022313-2675sjlf	320	10	forms	form	VBZ
cord-022313-2675sjlf	320	11	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	320	12	-	-	HYPH
cord-022313-2675sjlf	320	13	PP	PP	NNP
cord-022313-2675sjlf	320	14	-	-	HYPH
cord-022313-2675sjlf	320	15	dolichol	dolichol	NNP
cord-022313-2675sjlf	320	16	,	,	,
cord-022313-2675sjlf	320	17	and	and	CC
cord-022313-2675sjlf	320	18	the	the	DT
cord-022313-2675sjlf	320	19	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	320	20	transferase	transferase	NN
cord-022313-2675sjlf	320	21	that	that	WDT
cord-022313-2675sjlf	320	22	forms	form	VBZ
cord-022313-2675sjlf	320	23	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	320	24	-	-	HYPH
cord-022313-2675sjlf	320	25	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	320	26	-	-	HYPH
cord-022313-2675sjlf	320	27	PP	PP	NNP
cord-022313-2675sjlf	320	28	-	-	HYPH
cord-022313-2675sjlf	320	29	dolichol	dolichol	NNP
cord-022313-2675sjlf	320	30	(	(	-LRB-
cord-022313-2675sjlf	320	31	146	146	CD
cord-022313-2675sjlf	320	32	)	)	-RRB-
cord-022313-2675sjlf	320	33	.	.	.
cord-022313-2675sjlf	321	1	It	-PRON-	PRP
cord-022313-2675sjlf	321	2	seems	seem	VBZ
cord-022313-2675sjlf	321	3	likely	likely	JJ
cord-022313-2675sjlf	321	4	that	that	IN
cord-022313-2675sjlf	321	5	the	the	DT
cord-022313-2675sjlf	321	6	action	action	NN
cord-022313-2675sjlf	321	7	of	of	IN
cord-022313-2675sjlf	321	8	this	this	DT
cord-022313-2675sjlf	321	9	inhibitor	inhibitor	NN
cord-022313-2675sjlf	321	10	is	be	VBZ
cord-022313-2675sjlf	321	11	similar	similar	JJ
cord-022313-2675sjlf	321	12	to	to	IN
cord-022313-2675sjlf	321	13	that	that	DT
cord-022313-2675sjlf	321	14	of	of	IN
cord-022313-2675sjlf	321	15	ampho	ampho	NNP
cord-022313-2675sjlf	321	16	mycin	mycin	NNP
cord-022313-2675sjlf	321	17	;	;	,
cord-022313-2675sjlf	321	18	i.e.	i.e.	FW
cord-022313-2675sjlf	321	19	,	,	,
cord-022313-2675sjlf	321	20	it	-PRON-	PRP
cord-022313-2675sjlf	321	21	may	may	MD
cord-022313-2675sjlf	321	22	bind	bind	VB
cord-022313-2675sjlf	321	23	various	various	JJ
cord-022313-2675sjlf	321	24	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	321	25	derivatives	derivative	NNS
cord-022313-2675sjlf	321	26	under	under	IN
cord-022313-2675sjlf	321	27	the	the	DT
cord-022313-2675sjlf	321	28	right	right	JJ
cord-022313-2675sjlf	321	29	conditions	condition	NNS
cord-022313-2675sjlf	321	30	and	and	CC
cord-022313-2675sjlf	321	31	therefore	therefore	RB
cord-022313-2675sjlf	321	32	may	may	MD
cord-022313-2675sjlf	321	33	interfere	interfere	VB
cord-022313-2675sjlf	321	34	with	with	IN
cord-022313-2675sjlf	321	35	a	a	DT
cord-022313-2675sjlf	321	36	variety	variety	NN
cord-022313-2675sjlf	321	37	of	of	IN
cord-022313-2675sjlf	321	38	reactions	reaction	NNS
cord-022313-2675sjlf	321	39	in	in	IN
cord-022313-2675sjlf	321	40	the	the	DT
cord-022313-2675sjlf	321	41	"	"	``
cord-022313-2675sjlf	321	42	dolichol	dolichol	JJ
cord-022313-2675sjlf	321	43	cycle	cycle	NN
cord-022313-2675sjlf	321	44	.	.	.
cord-022313-2675sjlf	322	1	"	"	''
cord-022313-2675sjlf	323	1	Several	several	JJ
cord-022313-2675sjlf	323	2	other	other	JJ
cord-022313-2675sjlf	323	3	antibiotics	antibiotic	NNS
cord-022313-2675sjlf	323	4	that	that	WDT
cord-022313-2675sjlf	323	5	affect	affect	VBP
cord-022313-2675sjlf	323	6	the	the	DT
cord-022313-2675sjlf	323	7	synthesis	synthesis	NN
cord-022313-2675sjlf	323	8	of	of	IN
cord-022313-2675sjlf	323	9	bacterial	bacterial	JJ
cord-022313-2675sjlf	323	10	cell	cell	NN
cord-022313-2675sjlf	323	11	walls	wall	NNS
cord-022313-2675sjlf	323	12	are	be	VBP
cord-022313-2675sjlf	323	13	also	also	RB
cord-022313-2675sjlf	323	14	effective	effective	JJ
cord-022313-2675sjlf	323	15	on	on	IN
cord-022313-2675sjlf	323	16	the	the	DT
cord-022313-2675sjlf	323	17	reactions	reaction	NNS
cord-022313-2675sjlf	323	18	described	describe	VBN
cord-022313-2675sjlf	323	19	here	here	RB
cord-022313-2675sjlf	323	20	.	.	.
cord-022313-2675sjlf	324	1	Generally	generally	RB
cord-022313-2675sjlf	324	2	,	,	,
cord-022313-2675sjlf	324	3	these	these	DT
cord-022313-2675sjlf	324	4	compounds	compound	NNS
cord-022313-2675sjlf	324	5	have	have	VBP
cord-022313-2675sjlf	324	6	not	not	RB
cord-022313-2675sjlf	324	7	been	be	VBN
cord-022313-2675sjlf	324	8	well	well	RB
cord-022313-2675sjlf	324	9	defined	define	VBN
cord-022313-2675sjlf	324	10	structurally	structurally	RB
cord-022313-2675sjlf	324	11	or	or	CC
cord-022313-2675sjlf	324	12	functionally	functionally	RB
cord-022313-2675sjlf	324	13	,	,	,
cord-022313-2675sjlf	324	14	but	but	CC
cord-022313-2675sjlf	324	15	some	some	DT
cord-022313-2675sjlf	324	16	of	of	IN
cord-022313-2675sjlf	324	17	their	-PRON-	PRP$
cord-022313-2675sjlf	324	18	inhibitory	inhibitory	JJ
cord-022313-2675sjlf	324	19	actions	action	NNS
cord-022313-2675sjlf	324	20	have	have	VBP
cord-022313-2675sjlf	324	21	been	be	VBN
cord-022313-2675sjlf	324	22	reported	report	VBN
cord-022313-2675sjlf	324	23	.	.	.
cord-022313-2675sjlf	325	1	The	the	DT
cord-022313-2675sjlf	325	2	structure	structure	NN
cord-022313-2675sjlf	325	3	of	of	IN
cord-022313-2675sjlf	325	4	diumycin	diumycin	NNS
cord-022313-2675sjlf	325	5	is	be	VBZ
cord-022313-2675sjlf	325	6	not	not	RB
cord-022313-2675sjlf	325	7	known	know	VBN
cord-022313-2675sjlf	325	8	,	,	,
cord-022313-2675sjlf	325	9	but	but	CC
cord-022313-2675sjlf	325	10	it	-PRON-	PRP
cord-022313-2675sjlf	325	11	was	be	VBD
cord-022313-2675sjlf	325	12	reported	report	VBN
cord-022313-2675sjlf	325	13	to	to	TO
cord-022313-2675sjlf	325	14	inhibit	inhibit	VB
cord-022313-2675sjlf	325	15	the	the	DT
cord-022313-2675sjlf	325	16	formation	formation	NN
cord-022313-2675sjlf	325	17	of	of	IN
cord-022313-2675sjlf	325	18	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	325	19	-	-	HYPH
cord-022313-2675sjlf	325	20	P	p	NN
cord-022313-2675sjlf	325	21	-	-	HYPH
cord-022313-2675sjlf	325	22	mannose	mannose	NN
cord-022313-2675sjlf	325	23	in	in	IN
cord-022313-2675sjlf	325	24	a	a	DT
cord-022313-2675sjlf	325	25	yeast	yeast	NN
cord-022313-2675sjlf	325	26	membrane	membrane	NN
cord-022313-2675sjlf	325	27	preparation	preparation	NN
cord-022313-2675sjlf	325	28	,	,	,
cord-022313-2675sjlf	325	29	as	as	RB
cord-022313-2675sjlf	325	30	well	well	RB
cord-022313-2675sjlf	325	31	as	as	IN
cord-022313-2675sjlf	325	32	the	the	DT
cord-022313-2675sjlf	325	33	transfer	transfer	NN
cord-022313-2675sjlf	325	34	of	of	IN
cord-022313-2675sjlf	325	35	mannose	mannose	NN
cord-022313-2675sjlf	325	36	from	from	IN
cord-022313-2675sjlf	325	37	dolichyl	dolichyl	NN
cord-022313-2675sjlf	325	38	-	-	HYPH
cord-022313-2675sjlf	325	39	P	p	NN
cord-022313-2675sjlf	325	40	-	-	HYPH
cord-022313-2675sjlf	325	41	mannose	mannose	NN
cord-022313-2675sjlf	325	42	to	to	IN
cord-022313-2675sjlf	325	43	serine	serine	NN
cord-022313-2675sjlf	325	44	or	or	CC
cord-022313-2675sjlf	325	45	threonine	threonine	NN
cord-022313-2675sjlf	325	46	residues	residue	NNS
cord-022313-2675sjlf	325	47	(	(	-LRB-
cord-022313-2675sjlf	325	48	147	147	CD
cord-022313-2675sjlf	325	49	)	)	-RRB-
cord-022313-2675sjlf	325	50	.	.	.
cord-022313-2675sjlf	326	1	In	in	IN
cord-022313-2675sjlf	326	2	a	a	DT
cord-022313-2675sjlf	326	3	membrane	membrane	NN
cord-022313-2675sjlf	326	4	preparation	preparation	NN
cord-022313-2675sjlf	326	5	from	from	IN
cord-022313-2675sjlf	326	6	Acanthamoeba	Acanthamoeba	NNP
cord-022313-2675sjlf	326	7	,	,	,
cord-022313-2675sjlf	326	8	diu	diu	NNP
cord-022313-2675sjlf	326	9	mycin	mycin	NNP
cord-022313-2675sjlf	326	10	blocked	block	VBD
cord-022313-2675sjlf	326	11	the	the	DT
cord-022313-2675sjlf	326	12	transfer	transfer	NN
cord-022313-2675sjlf	326	13	of	of	IN
cord-022313-2675sjlf	326	14	mannose	mannose	NN
cord-022313-2675sjlf	326	15	and	and	CC
cord-022313-2675sjlf	326	16	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	326	17	to	to	IN
cord-022313-2675sjlf	326	18	lipid	lipid	NN
cord-022313-2675sjlf	326	19	-	-	HYPH
cord-022313-2675sjlf	326	20	linked	link	VBN
cord-022313-2675sjlf	326	21	monosaccharides	monosaccharide	NNS
cord-022313-2675sjlf	326	22	,	,	,
cord-022313-2675sjlf	326	23	but	but	CC
cord-022313-2675sjlf	326	24	it	-PRON-	PRP
cord-022313-2675sjlf	326	25	did	do	VBD
cord-022313-2675sjlf	326	26	not	not	RB
cord-022313-2675sjlf	326	27	affect	affect	VB
cord-022313-2675sjlf	326	28	the	the	DT
cord-022313-2675sjlf	326	29	synthesis	synthesis	NN
cord-022313-2675sjlf	326	30	of	of	IN
cord-022313-2675sjlf	326	31	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	326	32	-	-	:
cord-022313-2675sjlf	326	33	Pglucose	Pglucose	NNP
cord-022313-2675sjlf	326	34	(	(	-LRB-
cord-022313-2675sjlf	326	35	148	148	CD
cord-022313-2675sjlf	326	36	)	)	-RRB-
cord-022313-2675sjlf	326	37	.	.	.
cord-022313-2675sjlf	327	1	In	in	IN
cord-022313-2675sjlf	327	2	fact	fact	NN
cord-022313-2675sjlf	327	3	,	,	,
cord-022313-2675sjlf	327	4	diumycin	diumycin	NNS
cord-022313-2675sjlf	327	5	(	(	-LRB-
cord-022313-2675sjlf	327	6	and	and	CC
cord-022313-2675sjlf	327	7	another	another	DT
cord-022313-2675sjlf	327	8	antibiotic	antibiotic	NN
cord-022313-2675sjlf	327	9	,	,	,
cord-022313-2675sjlf	327	10	showdomycin	showdomycin	NNP
cord-022313-2675sjlf	327	11	)	)	-RRB-
cord-022313-2675sjlf	327	12	has	have	VBZ
cord-022313-2675sjlf	327	13	been	be	VBN
cord-022313-2675sjlf	327	14	used	use	VBN
cord-022313-2675sjlf	327	15	to	to	TO
cord-022313-2675sjlf	327	16	add	add	VB
cord-022313-2675sjlf	327	17	support	support	NN
cord-022313-2675sjlf	327	18	to	to	IN
cord-022313-2675sjlf	327	19	the	the	DT
cord-022313-2675sjlf	327	20	hypothesis	hypothesis	NN
cord-022313-2675sjlf	327	21	that	that	IN
cord-022313-2675sjlf	327	22	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	327	23	-	-	HYPH
cord-022313-2675sjlf	327	24	P	p	NN
cord-022313-2675sjlf	327	25	-	-	HYPH
cord-022313-2675sjlf	327	26	mannose	mannose	NN
cord-022313-2675sjlf	327	27	is	be	VBZ
cord-022313-2675sjlf	327	28	a	a	DT
cord-022313-2675sjlf	327	29	positive	positive	JJ
cord-022313-2675sjlf	327	30	regulator	regulator	NN
cord-022313-2675sjlf	327	31	of	of	IN
cord-022313-2675sjlf	327	32	the	the	DT
cord-022313-2675sjlf	327	33	GlcNAc-1-P	glcnac-1-p	JJ
cord-022313-2675sjlf	327	34	transferase	transferase	NN
cord-022313-2675sjlf	327	35	that	that	WDT
cord-022313-2675sjlf	327	36	forms	form	VBZ
cord-022313-2675sjlf	327	37	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	327	38	-	-	HYPH
cord-022313-2675sjlf	327	39	PP	PP	NNP
cord-022313-2675sjlf	327	40	-	-	HYPH
cord-022313-2675sjlf	327	41	dolichol	dolichol	NNP
cord-022313-2675sjlf	327	42	(	(	-LRB-
cord-022313-2675sjlf	327	43	143	143	CD
cord-022313-2675sjlf	327	44	)	)	-RRB-
cord-022313-2675sjlf	327	45	.	.	.
cord-022313-2675sjlf	328	1	Thus	thus	RB
cord-022313-2675sjlf	328	2	,	,	,
cord-022313-2675sjlf	328	3	when	when	WRB
cord-022313-2675sjlf	328	4	either	either	DT
cord-022313-2675sjlf	328	5	of	of	IN
cord-022313-2675sjlf	328	6	these	these	DT
cord-022313-2675sjlf	328	7	drugs	drug	NNS
cord-022313-2675sjlf	328	8	was	be	VBD
cord-022313-2675sjlf	328	9	added	add	VBN
cord-022313-2675sjlf	328	10	to	to	IN
cord-022313-2675sjlf	328	11	a	a	DT
cord-022313-2675sjlf	328	12	microsomal	microsomal	JJ
cord-022313-2675sjlf	328	13	preparation	preparation	NN
cord-022313-2675sjlf	328	14	,	,	,
cord-022313-2675sjlf	328	15	it	-PRON-	PRP
cord-022313-2675sjlf	328	16	blocked	block	VBD
cord-022313-2675sjlf	328	17	the	the	DT
cord-022313-2675sjlf	328	18	formation	formation	NN
cord-022313-2675sjlf	328	19	of	of	IN
cord-022313-2675sjlf	328	20	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	328	21	-	-	:
cord-022313-2675sjlf	328	22	Pmannose	Pmannose	NNP
cord-022313-2675sjlf	328	23	from	from	IN
cord-022313-2675sjlf	328	24	GDP	gdp	NN
cord-022313-2675sjlf	328	25	-	-	HYPH
cord-022313-2675sjlf	328	26	mannose	mannose	NN
cord-022313-2675sjlf	328	27	and	and	CC
cord-022313-2675sjlf	328	28	therefore	therefore	RB
cord-022313-2675sjlf	328	29	prevented	prevent	VBD
cord-022313-2675sjlf	328	30	the	the	DT
cord-022313-2675sjlf	328	31	stimulation	stimulation	NN
cord-022313-2675sjlf	328	32	of	of	IN
cord-022313-2675sjlf	328	33	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	328	34	-	-	HYPH
cord-022313-2675sjlf	328	35	PP	PP	NNP
cord-022313-2675sjlf	328	36	-	-	HYPH
cord-022313-2675sjlf	328	37	dolichol	dolichol	JJ
cord-022313-2675sjlf	328	38	formation	formation	NN
cord-022313-2675sjlf	328	39	by	by	IN
cord-022313-2675sjlf	328	40	GDP	gdp	NN
cord-022313-2675sjlf	328	41	-	-	HYPH
cord-022313-2675sjlf	328	42	mannose	mannose	NN
cord-022313-2675sjlf	328	43	.	.	.
cord-022313-2675sjlf	329	1	Flavomycin	Flavomycin	NNP
cord-022313-2675sjlf	329	2	is	be	VBZ
cord-022313-2675sjlf	329	3	an	an	DT
cord-022313-2675sjlf	329	4	antibiotic	antibiotic	NN
cord-022313-2675sjlf	329	5	of	of	IN
cord-022313-2675sjlf	329	6	the	the	DT
cord-022313-2675sjlf	329	7	moenomycin	moenomycin	NNP
cord-022313-2675sjlf	329	8	group	group	NN
cord-022313-2675sjlf	329	9	of	of	IN
cord-022313-2675sjlf	329	10	compounds	compound	NNS
cord-022313-2675sjlf	329	11	.	.	.
cord-022313-2675sjlf	330	1	This	this	DT
cord-022313-2675sjlf	330	2	drug	drug	NN
cord-022313-2675sjlf	330	3	interferes	interfere	VBZ
cord-022313-2675sjlf	330	4	with	with	IN
cord-022313-2675sjlf	330	5	the	the	DT
cord-022313-2675sjlf	330	6	formation	formation	NN
cord-022313-2675sjlf	330	7	of	of	IN
cord-022313-2675sjlf	330	8	lipid	lipid	NN
cord-022313-2675sjlf	330	9	-	-	HYPH
cord-022313-2675sjlf	330	10	linked	link	VBN
cord-022313-2675sjlf	330	11	saccharides	saccharide	NNS
cord-022313-2675sjlf	330	12	in	in	IN
cord-022313-2675sjlf	330	13	microsomes	microsome	NNS
cord-022313-2675sjlf	330	14	from	from	IN
cord-022313-2675sjlf	330	15	pig	pig	NN
cord-022313-2675sjlf	330	16	brain	brain	NN
cord-022313-2675sjlf	330	17	(	(	-LRB-
cord-022313-2675sjlf	330	18	149	149	CD
cord-022313-2675sjlf	330	19	)	)	-RRB-
cord-022313-2675sjlf	330	20	.	.	.
cord-022313-2675sjlf	331	1	Unfortunately	unfortunately	RB
cord-022313-2675sjlf	331	2	,	,	,
cord-022313-2675sjlf	331	3	no	no	DT
cord-022313-2675sjlf	331	4	other	other	JJ
cord-022313-2675sjlf	331	5	studies	study	NNS
cord-022313-2675sjlf	331	6	have	have	VBP
cord-022313-2675sjlf	331	7	been	be	VBN
cord-022313-2675sjlf	331	8	reported	report	VBN
cord-022313-2675sjlf	331	9	with	with	IN
cord-022313-2675sjlf	331	10	this	this	DT
cord-022313-2675sjlf	331	11	compound	compound	NN
cord-022313-2675sjlf	331	12	,	,	,
cord-022313-2675sjlf	331	13	so	so	IN
cord-022313-2675sjlf	331	14	additional	additional	JJ
cord-022313-2675sjlf	331	15	studies	study	NNS
cord-022313-2675sjlf	331	16	will	will	MD
cord-022313-2675sjlf	331	17	be	be	VB
cord-022313-2675sjlf	331	18	needed	need	VBN
cord-022313-2675sjlf	331	19	before	before	IN
cord-022313-2675sjlf	331	20	we	-PRON-	PRP
cord-022313-2675sjlf	331	21	can	can	MD
cord-022313-2675sjlf	331	22	understand	understand	VB
cord-022313-2675sjlf	331	23	its	-PRON-	PRP$
cord-022313-2675sjlf	331	24	mechanism	mechanism	NN
cord-022313-2675sjlf	331	25	of	of	IN
cord-022313-2675sjlf	331	26	action	action	NN
cord-022313-2675sjlf	331	27	.	.	.
cord-022313-2675sjlf	332	1	The	the	DT
cord-022313-2675sjlf	332	2	same	same	JJ
cord-022313-2675sjlf	332	3	applies	apply	VBZ
cord-022313-2675sjlf	332	4	to	to	IN
cord-022313-2675sjlf	332	5	diumycin	diumycin	NNS
cord-022313-2675sjlf	332	6	.	.	.
cord-022313-2675sjlf	333	1	Showdomycin	Showdomycin	NNP
cord-022313-2675sjlf	333	2	is	be	VBZ
cord-022313-2675sjlf	333	3	a	a	DT
cord-022313-2675sjlf	333	4	nucleoside	nucleoside	NN
cord-022313-2675sjlf	333	5	antibiotic	antibiotic	JJ
cord-022313-2675sjlf	333	6	whose	whose	WP$
cord-022313-2675sjlf	333	7	structure	structure	NN
cord-022313-2675sjlf	333	8	is	be	VBZ
cord-022313-2675sjlf	333	9	shown	show	VBN
cord-022313-2675sjlf	333	10	in	in	IN
cord-022313-2675sjlf	333	11	Fig	Fig	NNP
cord-022313-2675sjlf	333	12	.	.	.
cord-022313-2675sjlf	334	1	8	8	CD
cord-022313-2675sjlf	334	2	.	.	.
cord-022313-2675sjlf	335	1	This	this	DT
cord-022313-2675sjlf	335	2	compound	compound	NN
cord-022313-2675sjlf	335	3	has	have	VBZ
cord-022313-2675sjlf	335	4	a	a	DT
cord-022313-2675sjlf	335	5	maleimide	maleimide	NN
cord-022313-2675sjlf	335	6	group	group	NN
cord-022313-2675sjlf	335	7	that	that	WDT
cord-022313-2675sjlf	335	8	reacts	react	VBZ
cord-022313-2675sjlf	335	9	with	with	IN
cord-022313-2675sjlf	335	10	sulfhydryls	sulfhydryls	NN
cord-022313-2675sjlf	335	11	on	on	IN
cord-022313-2675sjlf	335	12	proteins	protein	NNS
cord-022313-2675sjlf	335	13	,	,	,
cord-022313-2675sjlf	335	14	and	and	CC
cord-022313-2675sjlf	335	15	this	this	DT
cord-022313-2675sjlf	335	16	reaction	reaction	NN
cord-022313-2675sjlf	335	17	is	be	VBZ
cord-022313-2675sjlf	335	18	probably	probably	RB
cord-022313-2675sjlf	335	19	the	the	DT
cord-022313-2675sjlf	335	20	basis	basis	NN
cord-022313-2675sjlf	335	21	of	of	IN
cord-022313-2675sjlf	335	22	the	the	DT
cord-022313-2675sjlf	335	23	show	show	NN
cord-022313-2675sjlf	335	24	domycin	domycin	NNS
cord-022313-2675sjlf	335	25	inhibition	inhibition	NN
cord-022313-2675sjlf	335	26	of	of	IN
cord-022313-2675sjlf	335	27	lipid	lipid	NN
cord-022313-2675sjlf	335	28	-	-	HYPH
cord-022313-2675sjlf	335	29	linked	link	VBN
cord-022313-2675sjlf	335	30	saccharide	saccharide	NN
cord-022313-2675sjlf	335	31	formation	formation	NN
cord-022313-2675sjlf	335	32	.	.	.
cord-022313-2675sjlf	336	1	In	in	IN
cord-022313-2675sjlf	336	2	cell	cell	NN
cord-022313-2675sjlf	336	3	-	-	HYPH
cord-022313-2675sjlf	336	4	free	free	JJ
cord-022313-2675sjlf	336	5	extracts	extract	NNS
cord-022313-2675sjlf	336	6	of	of	IN
cord-022313-2675sjlf	336	7	aorta	aorta	NN
cord-022313-2675sjlf	336	8	,	,	,
cord-022313-2675sjlf	336	9	the	the	DT
cord-022313-2675sjlf	336	10	synthesis	synthesis	NN
cord-022313-2675sjlf	336	11	of	of	IN
cord-022313-2675sjlf	336	12	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	336	13	-	-	HYPH
cord-022313-2675sjlf	336	14	P	p	NN
cord-022313-2675sjlf	336	15	-	-	HYPH
cord-022313-2675sjlf	336	16	mannose	mannose	NN
cord-022313-2675sjlf	336	17	and	and	CC
cord-022313-2675sjlf	336	18	dolichyl	dolichyl	NN
cord-022313-2675sjlf	336	19	-	-	HYPH
cord-022313-2675sjlf	336	20	P	p	NN
cord-022313-2675sjlf	336	21	-	-	HYPH
cord-022313-2675sjlf	336	22	glucose	glucose	NN
cord-022313-2675sjlf	336	23	were	be	VBD
cord-022313-2675sjlf	336	24	both	both	DT
cord-022313-2675sjlf	336	25	inhibited	inhibit	VBN
cord-022313-2675sjlf	336	26	by	by	IN
cord-022313-2675sjlf	336	27	this	this	DT
cord-022313-2675sjlf	336	28	drug	drug	NN
cord-022313-2675sjlf	336	29	,	,	,
cord-022313-2675sjlf	336	30	but	but	CC
cord-022313-2675sjlf	336	31	the	the	DT
cord-022313-2675sjlf	336	32	formation	formation	NN
cord-022313-2675sjlf	336	33	of	of	IN
cord-022313-2675sjlf	336	34	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	336	35	-	-	HYPH
cord-022313-2675sjlf	336	36	PP	PP	NNP
cord-022313-2675sjlf	336	37	-	-	HYPH
cord-022313-2675sjlf	336	38	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	336	39	was	be	VBD
cord-022313-2675sjlf	336	40	not	not	RB
cord-022313-2675sjlf	336	41	affected	affect	VBN
cord-022313-2675sjlf	336	42	(	(	-LRB-
cord-022313-2675sjlf	336	43	150	150	CD
cord-022313-2675sjlf	336	44	)	)	-RRB-
cord-022313-2675sjlf	336	45	.	.	.
cord-022313-2675sjlf	337	1	However	however	RB
cord-022313-2675sjlf	337	2	,	,	,
cord-022313-2675sjlf	337	3	in	in	IN
cord-022313-2675sjlf	337	4	Volvox	Volvox	NNP
cord-022313-2675sjlf	337	5	extracts	extract	NNS
cord-022313-2675sjlf	337	6	,	,	,
cord-022313-2675sjlf	337	7	the	the	DT
cord-022313-2675sjlf	337	8	syntheses	synthesis	NNS
cord-022313-2675sjlf	337	9	of	of	IN
cord-022313-2675sjlf	337	10	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	337	11	-	-	HYPH
cord-022313-2675sjlf	337	12	P	p	NN
cord-022313-2675sjlf	337	13	-	-	HYPH
cord-022313-2675sjlf	337	14	glucose	glucose	NN
cord-022313-2675sjlf	337	15	and	and	CC
cord-022313-2675sjlf	337	16	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	337	17	-	-	HYPH
cord-022313-2675sjlf	337	18	PP	PP	NNP
cord-022313-2675sjlf	337	19	-	-	HYPH
cord-022313-2675sjlf	337	20	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	337	21	were	be	VBD
cord-022313-2675sjlf	337	22	equally	equally	RB
cord-022313-2675sjlf	337	23	sensitive	sensitive	JJ
cord-022313-2675sjlf	337	24	to	to	IN
cord-022313-2675sjlf	337	25	showdomycin	showdomycin	NNS
cord-022313-2675sjlf	337	26	in	in	IN
cord-022313-2675sjlf	337	27	the	the	DT
cord-022313-2675sjlf	337	28	presence	presence	NN
cord-022313-2675sjlf	337	29	of	of	IN
cord-022313-2675sjlf	337	30	Triton	Triton	NNP
cord-022313-2675sjlf	337	31	X-100	x-100	RB
cord-022313-2675sjlf	337	32	,	,	,
cord-022313-2675sjlf	337	33	and	and	CC
cord-022313-2675sjlf	337	34	this	this	DT
cord-022313-2675sjlf	337	35	inhibition	inhibition	NN
cord-022313-2675sjlf	337	36	was	be	VBD
cord-022313-2675sjlf	337	37	reversed	reverse	VBN
cord-022313-2675sjlf	337	38	by	by	IN
cord-022313-2675sjlf	337	39	the	the	DT
cord-022313-2675sjlf	337	40	addition	addition	NN
cord-022313-2675sjlf	337	41	of	of	IN
cord-022313-2675sjlf	337	42	dithiothreitol	dithiothreitol	NNP
cord-022313-2675sjlf	337	43	(	(	-LRB-
cord-022313-2675sjlf	337	44	151	151	CD
cord-022313-2675sjlf	337	45	)	)	-RRB-
cord-022313-2675sjlf	337	46	.	.	.
cord-022313-2675sjlf	338	1	As	as	IN
cord-022313-2675sjlf	338	2	indicated	indicate	VBN
cord-022313-2675sjlf	338	3	earlier	early	RBR
cord-022313-2675sjlf	338	4	,	,	,
cord-022313-2675sjlf	338	5	showdomycin	showdomycin	NNP
cord-022313-2675sjlf	338	6	has	have	VBZ
cord-022313-2675sjlf	338	7	also	also	RB
cord-022313-2675sjlf	338	8	been	be	VBN
cord-022313-2675sjlf	338	9	used	use	VBN
cord-022313-2675sjlf	338	10	to	to	TO
cord-022313-2675sjlf	338	11	study	study	VB
cord-022313-2675sjlf	338	12	the	the	DT
cord-022313-2675sjlf	338	13	regulation	regulation	NN
cord-022313-2675sjlf	338	14	of	of	IN
cord-022313-2675sjlf	338	15	lipid	lipid	NN
cord-022313-2675sjlf	338	16	-	-	HYPH
cord-022313-2675sjlf	338	17	linked	link	VBN
cord-022313-2675sjlf	338	18	saccharide	saccharide	NN
cord-022313-2675sjlf	338	19	formation	formation	NN
cord-022313-2675sjlf	338	20	by	by	IN
cord-022313-2675sjlf	338	21	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	338	22	-	-	HYPH
cord-022313-2675sjlf	338	23	P	p	NN
cord-022313-2675sjlf	338	24	-	-	HYPH
cord-022313-2675sjlf	338	25	mannose	mannose	NN
cord-022313-2675sjlf	338	26	.	.	.
cord-022313-2675sjlf	339	1	Probably	probably	RB
cord-022313-2675sjlf	339	2	two	two	CD
cord-022313-2675sjlf	339	3	of	of	IN
cord-022313-2675sjlf	339	4	the	the	DT
cord-022313-2675sjlf	339	5	earliest	early	JJS
cord-022313-2675sjlf	339	6	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	339	7	of	of	IN
cord-022313-2675sjlf	339	8	viral	viral	JJ
cord-022313-2675sjlf	339	9	envelope	envelope	NN
cord-022313-2675sjlf	339	10	formation	formation	NN
cord-022313-2675sjlf	339	11	to	to	TO
cord-022313-2675sjlf	339	12	be	be	VB
cord-022313-2675sjlf	339	13	described	describe	VBN
cord-022313-2675sjlf	339	14	were	be	VBD
cord-022313-2675sjlf	339	15	glucosamine	glucosamine	NN
cord-022313-2675sjlf	339	16	(	(	-LRB-
cord-022313-2675sjlf	339	17	152	152	CD
cord-022313-2675sjlf	339	18	)	)	-RRB-
cord-022313-2675sjlf	339	19	and	and	CC
cord-022313-2675sjlf	339	20	2-deoxyglucose	2-deoxyglucose	CD
cord-022313-2675sjlf	339	21	(	(	-LRB-
cord-022313-2675sjlf	339	22	153	153	CD
cord-022313-2675sjlf	339	23	)	)	-RRB-
cord-022313-2675sjlf	339	24	.	.	.
cord-022313-2675sjlf	340	1	It	-PRON-	PRP
cord-022313-2675sjlf	340	2	is	be	VBZ
cord-022313-2675sjlf	340	3	now	now	RB
cord-022313-2675sjlf	340	4	known	know	VBN
cord-022313-2675sjlf	340	5	that	that	IN
cord-022313-2675sjlf	340	6	glucosamine	glucosamine	NN
cord-022313-2675sjlf	340	7	interferes	interfere	VBZ
cord-022313-2675sjlf	340	8	with	with	IN
cord-022313-2675sjlf	340	9	the	the	DT
cord-022313-2675sjlf	340	10	formation	formation	NN
cord-022313-2675sjlf	340	11	of	of	IN
cord-022313-2675sjlf	340	12	lipidlinked	lipidlinked	JJ
cord-022313-2675sjlf	340	13	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	340	14	and	and	CC
cord-022313-2675sjlf	340	15	blocks	block	VBZ
cord-022313-2675sjlf	340	16	protein	protein	NN
cord-022313-2675sjlf	340	17	glycosylation	glycosylation	NN
cord-022313-2675sjlf	340	18	.	.	.
cord-022313-2675sjlf	341	1	This	this	DT
cord-022313-2675sjlf	341	2	inhibi	inhibi	NN
cord-022313-2675sjlf	341	3	tion	tion	NN
cord-022313-2675sjlf	341	4	,	,	,
cord-022313-2675sjlf	341	5	however	however	RB
cord-022313-2675sjlf	341	6	,	,	,
cord-022313-2675sjlf	341	7	requires	require	VBZ
cord-022313-2675sjlf	341	8	intact	intact	JJ
cord-022313-2675sjlf	341	9	cells	cell	NNS
cord-022313-2675sjlf	341	10	and	and	CC
cord-022313-2675sjlf	341	11	involves	involve	VBZ
cord-022313-2675sjlf	341	12	the	the	DT
cord-022313-2675sjlf	341	13	metabolism	metabolism	NN
cord-022313-2675sjlf	341	14	of	of	IN
cord-022313-2675sjlf	341	15	glucosamine	glucosamine	NN
cord-022313-2675sjlf	341	16	probably	probably	RB
cord-022313-2675sjlf	341	17	to	to	IN
cord-022313-2675sjlf	341	18	an	an	DT
cord-022313-2675sjlf	341	19	intermediate	intermediate	JJ
cord-022313-2675sjlf	341	20	such	such	JJ
cord-022313-2675sjlf	341	21	as	as	IN
cord-022313-2675sjlf	341	22	UDP	udp	NN
cord-022313-2675sjlf	341	23	-	-	HYPH
cord-022313-2675sjlf	341	24	glucosamine	glucosamine	NN
cord-022313-2675sjlf	341	25	(	(	-LRB-
cord-022313-2675sjlf	341	26	154	154	CD
cord-022313-2675sjlf	341	27	)	)	-RRB-
cord-022313-2675sjlf	341	28	,	,	,
cord-022313-2675sjlf	341	29	which	which	WDT
cord-022313-2675sjlf	341	30	may	may	MD
cord-022313-2675sjlf	341	31	compete	compete	VB
cord-022313-2675sjlf	341	32	with	with	IN
cord-022313-2675sjlf	341	33	UDP	UDP	NNP
cord-022313-2675sjlf	341	34	-	-	HYPH
cord-022313-2675sjlf	341	35	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	341	36	for	for	IN
cord-022313-2675sjlf	341	37	various	various	JJ
cord-022313-2675sjlf	341	38	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	341	39	transferases	transferase	NNS
cord-022313-2675sjlf	341	40	.	.	.
cord-022313-2675sjlf	342	1	When	when	WRB
cord-022313-2675sjlf	342	2	MDCK	MDCK	NNP
cord-022313-2675sjlf	342	3	cells	cell	NNS
cord-022313-2675sjlf	342	4	were	be	VBD
cord-022313-2675sjlf	342	5	incubated	incubate	VBN
cord-022313-2675sjlf	342	6	in	in	IN
cord-022313-2675sjlf	342	7	the	the	DT
cord-022313-2675sjlf	342	8	presence	presence	NN
cord-022313-2675sjlf	342	9	of	of	IN
cord-022313-2675sjlf	342	10	1	1	CD
cord-022313-2675sjlf	342	11	mM	mm	CD
cord-022313-2675sjlf	342	12	glucosamine	glucosamine	NN
cord-022313-2675sjlf	342	13	,	,	,
cord-022313-2675sjlf	342	14	there	there	EX
cord-022313-2675sjlf	342	15	was	be	VBD
cord-022313-2675sjlf	342	16	a	a	DT
cord-022313-2675sjlf	342	17	complete	complete	JJ
cord-022313-2675sjlf	342	18	shift	shift	NN
cord-022313-2675sjlf	342	19	in	in	IN
cord-022313-2675sjlf	342	20	the	the	DT
cord-022313-2675sjlf	342	21	composition	composition	NN
cord-022313-2675sjlf	342	22	of	of	IN
cord-022313-2675sjlf	342	23	the	the	DT
cord-022313-2675sjlf	342	24	lipid	lipid	NN
cord-022313-2675sjlf	342	25	-	-	HYPH
cord-022313-2675sjlf	342	26	linked	link	VBN
cord-022313-2675sjlf	342	27	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	342	28	from	from	IN
cord-022313-2675sjlf	342	29	mostly	mostly	RB
cord-022313-2675sjlf	342	30	Glc	Glc	NNP
cord-022313-2675sjlf	342	31	3	3	CD
cord-022313-2675sjlf	342	32	Man	Man	NNP
cord-022313-2675sjlf	342	33	9	9	CD
cord-022313-2675sjlf	342	34	(	(	-LRB-
cord-022313-2675sjlf	342	35	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	342	36	)	)	-RRB-
cord-022313-2675sjlf	343	1	2	2	LS
cord-022313-2675sjlf	343	2	-PPdolichol	-PPdolichol	:
cord-022313-2675sjlf	343	3	in	in	IN
cord-022313-2675sjlf	343	4	normal	normal	JJ
cord-022313-2675sjlf	343	5	cells	cell	NNS
cord-022313-2675sjlf	343	6	to	to	IN
cord-022313-2675sjlf	343	7	Man	man	NN
cord-022313-2675sjlf	343	8	6	6	CD
cord-022313-2675sjlf	343	9	_	_	NN
cord-022313-2675sjlf	343	10	8	8	CD
cord-022313-2675sjlf	344	1	(	(	-LRB-
cord-022313-2675sjlf	344	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	344	3	)	)	-RRB-
cord-022313-2675sjlf	344	4	2	2	CD
cord-022313-2675sjlf	344	5	-PP	-PP	NNS
cord-022313-2675sjlf	344	6	-	-	HYPH
cord-022313-2675sjlf	344	7	dolichol	dolichol	JJ
cord-022313-2675sjlf	344	8	in	in	IN
cord-022313-2675sjlf	344	9	inhibited	inhibited	JJ
cord-022313-2675sjlf	344	10	cells	cell	NNS
cord-022313-2675sjlf	344	11	.	.	.
cord-022313-2675sjlf	345	1	This	this	DT
cord-022313-2675sjlf	345	2	shift	shift	NN
cord-022313-2675sjlf	345	3	to	to	IN
cord-022313-2675sjlf	345	4	smaller	small	JJR
cord-022313-2675sjlf	345	5	sized	sized	JJ
cord-022313-2675sjlf	345	6	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	345	7	-	-	HYPH
cord-022313-2675sjlf	345	8	lipids	lipid	NNS
cord-022313-2675sjlf	345	9	became	become	VBD
cord-022313-2675sjlf	345	10	even	even	RB
cord-022313-2675sjlf	345	11	more	more	RBR
cord-022313-2675sjlf	345	12	pronounced	pronounce	VBN
cord-022313-2675sjlf	345	13	when	when	WRB
cord-022313-2675sjlf	345	14	the	the	DT
cord-022313-2675sjlf	345	15	concentration	concentration	NN
cord-022313-2675sjlf	345	16	of	of	IN
cord-022313-2675sjlf	345	17	glucosamine	glucosamine	NN
cord-022313-2675sjlf	345	18	was	be	VBD
cord-022313-2675sjlf	345	19	raised	raise	VBN
cord-022313-2675sjlf	345	20	to	to	IN
cord-022313-2675sjlf	345	21	10	10	CD
cord-022313-2675sjlf	345	22	mM	mm	NN
cord-022313-2675sjlf	345	23	(	(	-LRB-
cord-022313-2675sjlf	345	24	155	155	CD
cord-022313-2675sjlf	345	25	)	)	-RRB-
cord-022313-2675sjlf	345	26	.	.	.
cord-022313-2675sjlf	346	1	The	the	DT
cord-022313-2675sjlf	346	2	glucosamine	glucosamine	NN
cord-022313-2675sjlf	346	3	effect	effect	NN
cord-022313-2675sjlf	346	4	could	could	MD
cord-022313-2675sjlf	346	5	be	be	VB
cord-022313-2675sjlf	346	6	reversed	reverse	VBN
cord-022313-2675sjlf	346	7	by	by	IN
cord-022313-2675sjlf	346	8	removal	removal	NN
cord-022313-2675sjlf	346	9	of	of	IN
cord-022313-2675sjlf	346	10	this	this	DT
cord-022313-2675sjlf	346	11	amino	amino	NN
cord-022313-2675sjlf	346	12	-	-	HYPH
cord-022313-2675sjlf	346	13	sugar	sugar	NN
cord-022313-2675sjlf	346	14	from	from	IN
cord-022313-2675sjlf	346	15	the	the	DT
cord-022313-2675sjlf	346	16	culture	culture	NN
cord-022313-2675sjlf	346	17	medium	medium	NN
cord-022313-2675sjlf	346	18	,	,	,
cord-022313-2675sjlf	346	19	but	but	CC
cord-022313-2675sjlf	346	20	the	the	DT
cord-022313-2675sjlf	346	21	exact	exact	JJ
cord-022313-2675sjlf	346	22	site	site	NN
cord-022313-2675sjlf	346	23	or	or	CC
cord-022313-2675sjlf	346	24	mechanism	mechanism	NN
cord-022313-2675sjlf	346	25	of	of	IN
cord-022313-2675sjlf	346	26	action	action	NN
cord-022313-2675sjlf	346	27	of	of	IN
cord-022313-2675sjlf	346	28	this	this	DT
cord-022313-2675sjlf	346	29	compound	compound	NN
cord-022313-2675sjlf	346	30	is	be	VBZ
cord-022313-2675sjlf	346	31	still	still	RB
cord-022313-2675sjlf	346	32	unknown	unknown	JJ
cord-022313-2675sjlf	346	33	.	.	.
cord-022313-2675sjlf	347	1	Interestingly	interestingly	RB
cord-022313-2675sjlf	347	2	enough	enough	RB
cord-022313-2675sjlf	347	3	,	,	,
cord-022313-2675sjlf	347	4	another	another	DT
cord-022313-2675sjlf	347	5	amino	amino	NN
cord-022313-2675sjlf	347	6	-	-	HYPH
cord-022313-2675sjlf	347	7	sugar	sugar	NN
cord-022313-2675sjlf	347	8	,	,	,
cord-022313-2675sjlf	347	9	mannosamine	mannosamine	NN
cord-022313-2675sjlf	347	10	,	,	,
cord-022313-2675sjlf	347	11	also	also	RB
cord-022313-2675sjlf	347	12	in	in	IN
cord-022313-2675sjlf	347	13	hibits	hibit	NNS
cord-022313-2675sjlf	347	14	the	the	DT
cord-022313-2675sjlf	347	15	formation	formation	NN
cord-022313-2675sjlf	347	16	of	of	IN
cord-022313-2675sjlf	347	17	lipid	lipid	NN
cord-022313-2675sjlf	347	18	-	-	HYPH
cord-022313-2675sjlf	347	19	linked	link	VBN
cord-022313-2675sjlf	347	20	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	347	21	,	,	,
cord-022313-2675sjlf	347	22	but	but	CC
cord-022313-2675sjlf	347	23	the	the	DT
cord-022313-2675sjlf	347	24	mecha	mecha	JJ
cord-022313-2675sjlf	347	25	nism	nism	NN
cord-022313-2675sjlf	347	26	of	of	IN
cord-022313-2675sjlf	347	27	action	action	NN
cord-022313-2675sjlf	347	28	of	of	IN
cord-022313-2675sjlf	347	29	this	this	DT
cord-022313-2675sjlf	347	30	compound	compound	NN
cord-022313-2675sjlf	347	31	is	be	VBZ
cord-022313-2675sjlf	347	32	quite	quite	RB
cord-022313-2675sjlf	347	33	different	different	JJ
cord-022313-2675sjlf	347	34	from	from	IN
cord-022313-2675sjlf	347	35	that	that	DT
cord-022313-2675sjlf	347	36	of	of	IN
cord-022313-2675sjlf	347	37	glucos	glucos	NNP
cord-022313-2675sjlf	347	38	amine	amine	NN
cord-022313-2675sjlf	347	39	.	.	.
cord-022313-2675sjlf	348	1	The	the	DT
cord-022313-2675sjlf	348	2	inhibition	inhibition	NN
cord-022313-2675sjlf	348	3	by	by	IN
cord-022313-2675sjlf	348	4	mannosamine	mannosamine	NNP
cord-022313-2675sjlf	348	5	was	be	VBD
cord-022313-2675sjlf	348	6	dose	dose	NN
cord-022313-2675sjlf	348	7	-	-	HYPH
cord-022313-2675sjlf	348	8	dependent	dependent	JJ
cord-022313-2675sjlf	348	9	and	and	CC
cord-022313-2675sjlf	348	10	resulted	result	VBD
cord-022313-2675sjlf	348	11	in	in	IN
cord-022313-2675sjlf	348	12	a	a	DT
cord-022313-2675sjlf	348	13	shift	shift	NN
cord-022313-2675sjlf	348	14	in	in	IN
cord-022313-2675sjlf	348	15	the	the	DT
cord-022313-2675sjlf	348	16	size	size	NN
cord-022313-2675sjlf	348	17	of	of	IN
cord-022313-2675sjlf	348	18	the	the	DT
cord-022313-2675sjlf	348	19	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	348	20	moieties	moiety	NNS
cord-022313-2675sjlf	348	21	of	of	IN
cord-022313-2675sjlf	348	22	the	the	DT
cord-022313-2675sjlf	348	23	lipid	lipid	NN
cord-022313-2675sjlf	348	24	-	-	HYPH
cord-022313-2675sjlf	348	25	linked	link	VBN
cord-022313-2675sjlf	348	26	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	348	27	from	from	IN
cord-022313-2675sjlf	348	28	Glc	Glc	NNP
cord-022313-2675sjlf	348	29	3	3	CD
cord-022313-2675sjlf	348	30	Man	Man	NNP
cord-022313-2675sjlf	348	31	9	9	CD
cord-022313-2675sjlf	348	32	(	(	-LRB-
cord-022313-2675sjlf	348	33	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	348	34	)	)	-RRB-
cord-022313-2675sjlf	348	35	2	2	CD
cord-022313-2675sjlf	348	36	-PP	-PP	NNS
cord-022313-2675sjlf	348	37	-	-	HYPH
cord-022313-2675sjlf	348	38	dolichol	dolichol	JJ
cord-022313-2675sjlf	348	39	to	to	IN
cord-022313-2675sjlf	348	40	lipids	lipid	NNS
cord-022313-2675sjlf	348	41	with	with	IN
cord-022313-2675sjlf	348	42	Man	man	NN
cord-022313-2675sjlf	348	43	3	3	CD
cord-022313-2675sjlf	349	1	(	(	-LRB-
cord-022313-2675sjlf	349	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	349	3	)	)	-RRB-
cord-022313-2675sjlf	349	4	2	2	CD
cord-022313-2675sjlf	349	5	to	to	IN
cord-022313-2675sjlf	349	6	Man	man	NN
cord-022313-2675sjlf	349	7	9	9	CD
cord-022313-2675sjlf	349	8	(	(	-LRB-
cord-022313-2675sjlf	349	9	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	349	10	)	)	-RRB-
cord-022313-2675sjlf	349	11	2	2	CD
cord-022313-2675sjlf	349	12	.	.	.
cord-022313-2675sjlf	350	1	The	the	DT
cord-022313-2675sjlf	350	2	major	major	JJ
cord-022313-2675sjlf	350	3	species	specie	NNS
cord-022313-2675sjlf	350	4	were	be	VBD
cord-022313-2675sjlf	350	5	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	350	6	having	have	VBG
cord-022313-2675sjlf	350	7	five	five	CD
cord-022313-2675sjlf	350	8	or	or	CC
cord-022313-2675sjlf	350	9	six	six	CD
cord-022313-2675sjlf	350	10	mannose	mannose	NN
cord-022313-2675sjlf	350	11	residues	residue	NNS
cord-022313-2675sjlf	350	12	.	.	.
cord-022313-2675sjlf	351	1	These	these	DT
cord-022313-2675sjlf	351	2	studies	study	NNS
cord-022313-2675sjlf	351	3	demonstrated	demonstrate	VBD
cord-022313-2675sjlf	351	4	that	that	IN
cord-022313-2675sjlf	351	5	mannosamine	mannosamine	NN
cord-022313-2675sjlf	351	6	itself	-PRON-	PRP
cord-022313-2675sjlf	351	7	was	be	VBD
cord-022313-2675sjlf	351	8	incorporated	incorporate	VBN
cord-022313-2675sjlf	351	9	into	into	IN
cord-022313-2675sjlf	351	10	the	the	DT
cord-022313-2675sjlf	351	11	lipidlinked	lipidlinked	JJ
cord-022313-2675sjlf	351	12	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	351	13	,	,	,
cord-022313-2675sjlf	351	14	mostly	mostly	RB
cord-022313-2675sjlf	351	15	in	in	IN
cord-022313-2675sjlf	351	16	place	place	NN
cord-022313-2675sjlf	351	17	of	of	IN
cord-022313-2675sjlf	351	18	the	the	DT
cord-022313-2675sjlf	351	19	mannose	mannose	NN
cord-022313-2675sjlf	351	20	that	that	WDT
cord-022313-2675sjlf	351	21	is	be	VBZ
cord-022313-2675sjlf	351	22	in	in	IN
cord-022313-2675sjlf	351	23	al,3linkage	al,3linkage	NN
cord-022313-2675sjlf	352	1	to	to	IN
cord-022313-2675sjlf	352	2	the	the	DT
cord-022313-2675sjlf	352	3	β	β	NN
cord-022313-2675sjlf	352	4	-	-	HYPH
cord-022313-2675sjlf	352	5	linked	link	VBN
cord-022313-2675sjlf	352	6	mannose	mannose	NN
cord-022313-2675sjlf	352	7	.	.	.
cord-022313-2675sjlf	353	1	This	this	DT
cord-022313-2675sjlf	353	2	substitution	substitution	NN
cord-022313-2675sjlf	353	3	appears	appear	VBZ
cord-022313-2675sjlf	353	4	to	to	TO
cord-022313-2675sjlf	353	5	prevent	prevent	VB
cord-022313-2675sjlf	353	6	the	the	DT
cord-022313-2675sjlf	353	7	addition	addition	NN
cord-022313-2675sjlf	353	8	of	of	IN
cord-022313-2675sjlf	353	9	the	the	DT
cord-022313-2675sjlf	353	10	al,2-linked	al,2-linked	JJ
cord-022313-2675sjlf	353	11	mannose	mannose	NN
cord-022313-2675sjlf	353	12	to	to	IN
cord-022313-2675sjlf	353	13	this	this	DT
cord-022313-2675sjlf	353	14	al,3-linked	al,3-linked	NNP
cord-022313-2675sjlf	353	15	mannosam	mannosam	NNP
cord-022313-2675sjlf	353	16	ine	ine	NNP
cord-022313-2675sjlf	353	17	(	(	-LRB-
cord-022313-2675sjlf	353	18	156	156	CD
cord-022313-2675sjlf	353	19	)	)	-RRB-
cord-022313-2675sjlf	353	20	.	.	.
cord-022313-2675sjlf	354	1	In	in	IN
cord-022313-2675sjlf	354	2	the	the	DT
cord-022313-2675sjlf	354	3	presence	presence	NN
cord-022313-2675sjlf	354	4	of	of	IN
cord-022313-2675sjlf	354	5	mannosamine	mannosamine	NNP
cord-022313-2675sjlf	354	6	,	,	,
cord-022313-2675sjlf	354	7	a	a	DT
cord-022313-2675sjlf	354	8	series	series	NN
cord-022313-2675sjlf	354	9	of	of	IN
cord-022313-2675sjlf	354	10	basic	basic	JJ
cord-022313-2675sjlf	354	11	oligosaccha	oligosaccha	NNP
cord-022313-2675sjlf	354	12	rides	ride	NNS
cord-022313-2675sjlf	354	13	linked	link	VBN
cord-022313-2675sjlf	354	14	to	to	IN
cord-022313-2675sjlf	354	15	dolichol	dolichol	NNP
cord-022313-2675sjlf	354	16	were	be	VBD
cord-022313-2675sjlf	354	17	formed	form	VBN
cord-022313-2675sjlf	354	18	,	,	,
cord-022313-2675sjlf	354	19	and	and	CC
cord-022313-2675sjlf	354	20	at	at	IN
cord-022313-2675sjlf	354	21	least	least	JJS
cord-022313-2675sjlf	354	22	some	some	DT
cord-022313-2675sjlf	354	23	of	of	IN
cord-022313-2675sjlf	354	24	these	these	DT
cord-022313-2675sjlf	354	25	oligosac	oligosac	NNP
cord-022313-2675sjlf	354	26	charides	charides	NNP
cord-022313-2675sjlf	354	27	were	be	VBD
cord-022313-2675sjlf	354	28	still	still	RB
cord-022313-2675sjlf	354	29	transferred	transfer	VBN
cord-022313-2675sjlf	354	30	to	to	IN
cord-022313-2675sjlf	354	31	protein	protein	NN
cord-022313-2675sjlf	354	32	.	.	.
cord-022313-2675sjlf	355	1	However	however	RB
cord-022313-2675sjlf	355	2	,	,	,
cord-022313-2675sjlf	355	3	it	-PRON-	PRP
cord-022313-2675sjlf	355	4	is	be	VBZ
cord-022313-2675sjlf	355	5	not	not	RB
cord-022313-2675sjlf	355	6	clear	clear	JJ
cord-022313-2675sjlf	355	7	whether	whether	IN
cord-022313-2675sjlf	355	8	these	these	DT
cord-022313-2675sjlf	355	9	altered	alter	VBN
cord-022313-2675sjlf	355	10	glycopeptides	glycopeptide	NNS
cord-022313-2675sjlf	355	11	can	can	MD
cord-022313-2675sjlf	355	12	be	be	VB
cord-022313-2675sjlf	355	13	processed	process	VBN
cord-022313-2675sjlf	355	14	by	by	IN
cord-022313-2675sjlf	355	15	the	the	DT
cord-022313-2675sjlf	355	16	normal	normal	JJ
cord-022313-2675sjlf	355	17	pathway	pathway	NN
cord-022313-2675sjlf	355	18	or	or	CC
cord-022313-2675sjlf	355	19	they	-PRON-	PRP
cord-022313-2675sjlf	355	20	accumulate	accumulate	VBP
cord-022313-2675sjlf	355	21	in	in	IN
cord-022313-2675sjlf	355	22	the	the	DT
cord-022313-2675sjlf	355	23	cells	cell	NNS
cord-022313-2675sjlf	355	24	as	as	IN
cord-022313-2675sjlf	355	25	mannosamine	mannosamine	NN
cord-022313-2675sjlf	355	26	and	and	CC
cord-022313-2675sjlf	355	27	mannose	mannose	NN
cord-022313-2675sjlf	355	28	containing	contain	VBG
cord-022313-2675sjlf	355	29	structures	structure	NNS
cord-022313-2675sjlf	355	30	.	.	.
cord-022313-2675sjlf	356	1	In	in	IN
cord-022313-2675sjlf	356	2	terms	term	NNS
cord-022313-2675sjlf	356	3	of	of	IN
cord-022313-2675sjlf	356	4	glucose	glucose	NN
cord-022313-2675sjlf	356	5	analogs	analog	NNS
cord-022313-2675sjlf	356	6	,	,	,
cord-022313-2675sjlf	356	7	such	such	JJ
cord-022313-2675sjlf	356	8	as	as	IN
cord-022313-2675sjlf	356	9	2-deoxyglucose	2-deoxyglucose	CD
cord-022313-2675sjlf	356	10	,	,	,
cord-022313-2675sjlf	356	11	it	-PRON-	PRP
cord-022313-2675sjlf	356	12	is	be	VBZ
cord-022313-2675sjlf	356	13	now	now	RB
cord-022313-2675sjlf	356	14	clear	clear	JJ
cord-022313-2675sjlf	356	15	that	that	IN
cord-022313-2675sjlf	356	16	this	this	DT
cord-022313-2675sjlf	356	17	sugar	sugar	NN
cord-022313-2675sjlf	356	18	is	be	VBZ
cord-022313-2675sjlf	356	19	metabolized	metabolize	VBN
cord-022313-2675sjlf	356	20	in	in	IN
cord-022313-2675sjlf	356	21	cells	cell	NNS
cord-022313-2675sjlf	356	22	and	and	CC
cord-022313-2675sjlf	356	23	is	be	VBZ
cord-022313-2675sjlf	356	24	converted	convert	VBN
cord-022313-2675sjlf	356	25	to	to	IN
cord-022313-2675sjlf	356	26	UDP-2deoxyglucose	udp-2deoxyglucose	NN
cord-022313-2675sjlf	356	27	and	and	CC
cord-022313-2675sjlf	356	28	GDP-2-deoxyglucose	gdp-2-deoxyglucose	VB
cord-022313-2675sjlf	356	29	,	,	,
cord-022313-2675sjlf	356	30	as	as	RB
cord-022313-2675sjlf	356	31	well	well	RB
cord-022313-2675sjlf	356	32	as	as	IN
cord-022313-2675sjlf	356	33	to	to	IN
cord-022313-2675sjlf	356	34	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	356	35	-	-	:
cord-022313-2675sjlf	356	36	P-2deoxyglucose	P-2deoxyglucose	NNP
cord-022313-2675sjlf	356	37	.	.	.
cord-022313-2675sjlf	357	1	The	the	DT
cord-022313-2675sjlf	357	2	inhibition	inhibition	NN
cord-022313-2675sjlf	357	3	of	of	IN
cord-022313-2675sjlf	357	4	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	357	5	synthesis	synthesis	NN
cord-022313-2675sjlf	357	6	by	by	IN
cord-022313-2675sjlf	357	7	this	this	DT
cord-022313-2675sjlf	357	8	deoxysugar	deoxysugar	NN
cord-022313-2675sjlf	357	9	appears	appear	VBZ
cord-022313-2675sjlf	357	10	to	to	TO
cord-022313-2675sjlf	357	11	be	be	VB
cord-022313-2675sjlf	357	12	due	due	JJ
cord-022313-2675sjlf	357	13	to	to	IN
cord-022313-2675sjlf	357	14	the	the	DT
cord-022313-2675sjlf	357	15	GDP-2-deoxymannose	GDP-2-deoxymannose	NNS
cord-022313-2675sjlf	357	16	(	(	-LRB-
cord-022313-2675sjlf	357	17	glucose	glucose	NN
cord-022313-2675sjlf	357	18	)	)	-RRB-
cord-022313-2675sjlf	357	19	,	,	,
cord-022313-2675sjlf	357	20	because	because	IN
cord-022313-2675sjlf	357	21	mannose	mannose	NN
cord-022313-2675sjlf	357	22	itself	-PRON-	PRP
cord-022313-2675sjlf	357	23	can	can	MD
cord-022313-2675sjlf	357	24	reverse	reverse	VB
cord-022313-2675sjlf	357	25	the	the	DT
cord-022313-2675sjlf	357	26	inhibition	inhibition	NN
cord-022313-2675sjlf	357	27	(	(	-LRB-
cord-022313-2675sjlf	357	28	157	157	CD
cord-022313-2675sjlf	357	29	)	)	-RRB-
cord-022313-2675sjlf	357	30	.	.	.
cord-022313-2675sjlf	358	1	Probably	probably	RB
cord-022313-2675sjlf	358	2	when	when	WRB
cord-022313-2675sjlf	358	3	deoxyglucose	deoxyglucose	NNP
cord-022313-2675sjlf	358	4	is	be	VBZ
cord-022313-2675sjlf	358	5	incorporated	incorporate	VBN
cord-022313-2675sjlf	358	6	into	into	IN
cord-022313-2675sjlf	358	7	the	the	DT
cord-022313-2675sjlf	358	8	lipid	lipid	NN
cord-022313-2675sjlf	358	9	-	-	HYPH
cord-022313-2675sjlf	358	10	linked	link	VBN
cord-022313-2675sjlf	358	11	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	358	12	instead	instead	RB
cord-022313-2675sjlf	358	13	of	of	IN
cord-022313-2675sjlf	358	14	the	the	DT
cord-022313-2675sjlf	358	15	mannose	mannose	NN
cord-022313-2675sjlf	358	16	at	at	IN
cord-022313-2675sjlf	358	17	the	the	DT
cord-022313-2675sjlf	358	18	3-branch	3-branch	CD
cord-022313-2675sjlf	358	19	,	,	,
cord-022313-2675sjlf	358	20	it	-PRON-	PRP
cord-022313-2675sjlf	358	21	acts	act	VBZ
cord-022313-2675sjlf	358	22	like	like	IN
cord-022313-2675sjlf	358	23	mannosamine	mannosamine	NN
cord-022313-2675sjlf	358	24	and	and	CC
cord-022313-2675sjlf	358	25	prevents	prevent	VBZ
cord-022313-2675sjlf	358	26	further	further	JJ
cord-022313-2675sjlf	358	27	extension	extension	NN
cord-022313-2675sjlf	358	28	of	of	IN
cord-022313-2675sjlf	358	29	this	this	DT
cord-022313-2675sjlf	358	30	chain	chain	NN
cord-022313-2675sjlf	358	31	because	because	IN
cord-022313-2675sjlf	358	32	additional	additional	JJ
cord-022313-2675sjlf	358	33	mannoses	mannose	NNS
cord-022313-2675sjlf	358	34	are	be	VBP
cord-022313-2675sjlf	358	35	linked	link	VBN
cord-022313-2675sjlf	358	36	in	in	IN
cord-022313-2675sjlf	358	37	al,2-bonds	al,2-bond	NNS
cord-022313-2675sjlf	358	38	.	.	.
cord-022313-2675sjlf	359	1	These	these	DT
cord-022313-2675sjlf	359	2	2-deoxyglucose	2-deoxyglucose	CD
cord-022313-2675sjlf	359	3	-	-	HYPH
cord-022313-2675sjlf	359	4	containing	contain	VBG
cord-022313-2675sjlf	359	5	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	359	6	ap	ap	NNP
cord-022313-2675sjlf	359	7	peared	peare	VBD
cord-022313-2675sjlf	359	8	not	not	RB
cord-022313-2675sjlf	359	9	to	to	TO
cord-022313-2675sjlf	359	10	be	be	VB
cord-022313-2675sjlf	359	11	transferred	transfer	VBN
cord-022313-2675sjlf	359	12	to	to	IN
cord-022313-2675sjlf	359	13	protein	protein	NN
cord-022313-2675sjlf	359	14	in	in	IN
cord-022313-2675sjlf	359	15	contrast	contrast	NN
cord-022313-2675sjlf	359	16	to	to	IN
cord-022313-2675sjlf	359	17	the	the	DT
cord-022313-2675sjlf	359	18	situation	situation	NN
cord-022313-2675sjlf	359	19	with	with	IN
cord-022313-2675sjlf	359	20	the	the	DT
cord-022313-2675sjlf	359	21	mannosamine	mannosamine	NN
cord-022313-2675sjlf	359	22	-	-	HYPH
cord-022313-2675sjlf	359	23	containing	contain	VBG
cord-022313-2675sjlf	359	24	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	359	25	(	(	-LRB-
cord-022313-2675sjlf	359	26	from	from	IN
cord-022313-2675sjlf	359	27	the	the	DT
cord-022313-2675sjlf	359	28	lipid	lipid	NN
cord-022313-2675sjlf	359	29	-	-	HYPH
cord-022313-2675sjlf	359	30	linked	link	VBN
cord-022313-2675sjlf	359	31	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	359	32	)	)	-RRB-
cord-022313-2675sjlf	359	33	.	.	.
cord-022313-2675sjlf	360	1	A	a	DT
cord-022313-2675sjlf	360	2	number	number	NN
cord-022313-2675sjlf	360	3	of	of	IN
cord-022313-2675sjlf	360	4	fluoro	fluoro	NN
cord-022313-2675sjlf	360	5	-	-	HYPH
cord-022313-2675sjlf	360	6	sugars	sugar	NNS
cord-022313-2675sjlf	360	7	such	such	JJ
cord-022313-2675sjlf	360	8	as	as	IN
cord-022313-2675sjlf	360	9	2-deoxy-2-fluoro	2-deoxy-2-fluoro	CD
cord-022313-2675sjlf	360	10	-	-	HYPH
cord-022313-2675sjlf	360	11	D	d	NN
cord-022313-2675sjlf	360	12	-	-	HYPH
cord-022313-2675sjlf	360	13	mannose	mannose	NN
cord-022313-2675sjlf	360	14	,	,	,
cord-022313-2675sjlf	360	15	and	and	CC
cord-022313-2675sjlf	360	16	4-deoxy-4-fluoro	4-deoxy-4-fluoro	CD
cord-022313-2675sjlf	360	17	-	-	HYPH
cord-022313-2675sjlf	360	18	D	d	NN
cord-022313-2675sjlf	360	19	-	-	HYPH
cord-022313-2675sjlf	360	20	mannose	mannose	NN
cord-022313-2675sjlf	360	21	have	have	VBP
cord-022313-2675sjlf	360	22	also	also	RB
cord-022313-2675sjlf	360	23	been	be	VBN
cord-022313-2675sjlf	360	24	shown	show	VBN
cord-022313-2675sjlf	360	25	to	to	TO
cord-022313-2675sjlf	360	26	be	be	VB
cord-022313-2675sjlf	360	27	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	360	28	of	of	IN
cord-022313-2675sjlf	360	29	glycosylation	glycosylation	NN
cord-022313-2675sjlf	360	30	(	(	-LRB-
cord-022313-2675sjlf	360	31	158	158	CD
cord-022313-2675sjlf	360	32	)	)	-RRB-
cord-022313-2675sjlf	360	33	.	.	.
cord-022313-2675sjlf	361	1	It	-PRON-	PRP
cord-022313-2675sjlf	361	2	seems	seem	VBZ
cord-022313-2675sjlf	361	3	likely	likely	JJ
cord-022313-2675sjlf	361	4	that	that	IN
cord-022313-2675sjlf	361	5	the	the	DT
cord-022313-2675sjlf	361	6	mechanism	mechanism	NN
cord-022313-2675sjlf	361	7	of	of	IN
cord-022313-2675sjlf	361	8	action	action	NN
cord-022313-2675sjlf	361	9	of	of	IN
cord-022313-2675sjlf	361	10	these	these	DT
cord-022313-2675sjlf	361	11	analogs	analog	NNS
cord-022313-2675sjlf	361	12	is	be	VBZ
cord-022313-2675sjlf	361	13	similar	similar	JJ
cord-022313-2675sjlf	361	14	to	to	IN
cord-022313-2675sjlf	361	15	that	that	DT
cord-022313-2675sjlf	361	16	of	of	IN
cord-022313-2675sjlf	361	17	2-deoxyglucose	2-deoxyglucose	CD
cord-022313-2675sjlf	361	18	.	.	.
cord-022313-2675sjlf	362	1	Some	some	DT
cord-022313-2675sjlf	362	2	animal	animal	NN
cord-022313-2675sjlf	362	3	cells	cell	NNS
cord-022313-2675sjlf	362	4	,	,	,
cord-022313-2675sjlf	362	5	especially	especially	RB
cord-022313-2675sjlf	362	6	Chinese	chinese	JJ
cord-022313-2675sjlf	362	7	hamster	hamster	NN
cord-022313-2675sjlf	362	8	ovary	ovary	NN
cord-022313-2675sjlf	362	9	(	(	-LRB-
cord-022313-2675sjlf	362	10	CHO	CHO	NNP
cord-022313-2675sjlf	362	11	)	)	-RRB-
cord-022313-2675sjlf	362	12	cells	cell	NNS
cord-022313-2675sjlf	362	13	,	,	,
cord-022313-2675sjlf	362	14	show	show	VBP
cord-022313-2675sjlf	362	15	a	a	DT
cord-022313-2675sjlf	362	16	phenomenon	phenomenon	NN
cord-022313-2675sjlf	362	17	that	that	WDT
cord-022313-2675sjlf	362	18	has	have	VBZ
cord-022313-2675sjlf	362	19	been	be	VBN
cord-022313-2675sjlf	362	20	called	call	VBN
cord-022313-2675sjlf	362	21	"	"	``
cord-022313-2675sjlf	362	22	glucose	glucose	NN
cord-022313-2675sjlf	362	23	starvation	starvation	NN
cord-022313-2675sjlf	362	24	.	.	.
cord-022313-2675sjlf	362	25	"	"	''
cord-022313-2675sjlf	363	1	Thus	thus	RB
cord-022313-2675sjlf	363	2	,	,	,
cord-022313-2675sjlf	363	3	when	when	WRB
cord-022313-2675sjlf	363	4	glucose	glucose	NN
cord-022313-2675sjlf	363	5	is	be	VBZ
cord-022313-2675sjlf	363	6	removed	remove	VBN
cord-022313-2675sjlf	363	7	from	from	IN
cord-022313-2675sjlf	363	8	the	the	DT
cord-022313-2675sjlf	363	9	medium	medium	NN
cord-022313-2675sjlf	363	10	,	,	,
cord-022313-2675sjlf	363	11	these	these	DT
cord-022313-2675sjlf	363	12	cells	cell	NNS
cord-022313-2675sjlf	363	13	can	can	MD
cord-022313-2675sjlf	363	14	no	no	RB
cord-022313-2675sjlf	363	15	longer	longer	RB
cord-022313-2675sjlf	363	16	produce	produce	VB
cord-022313-2675sjlf	363	17	the	the	DT
cord-022313-2675sjlf	363	18	typical	typical	JJ
cord-022313-2675sjlf	363	19	Glc	Glc	NNP
cord-022313-2675sjlf	363	20	3	3	CD
cord-022313-2675sjlf	363	21	Man	Man	NNP
cord-022313-2675sjlf	363	22	9	9	CD
cord-022313-2675sjlf	363	23	(	(	-LRB-
cord-022313-2675sjlf	363	24	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	363	25	)	)	-RRB-
cord-022313-2675sjlf	363	26	2	2	CD
cord-022313-2675sjlf	363	27	-PP	-PP	NNS
cord-022313-2675sjlf	363	28	-	-	HYPH
cord-022313-2675sjlf	363	29	dolichol	dolichol	JJ
cord-022313-2675sjlf	363	30	that	that	WDT
cord-022313-2675sjlf	363	31	is	be	VBZ
cord-022313-2675sjlf	363	32	the	the	DT
cord-022313-2675sjlf	363	33	natural	natural	JJ
cord-022313-2675sjlf	363	34	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	363	35	donor	donor	NN
cord-022313-2675sjlf	363	36	for	for	IN
cord-022313-2675sjlf	363	37	N	n	NN
cord-022313-2675sjlf	363	38	-	-	HYPH
cord-022313-2675sjlf	363	39	linked	link	VBN
cord-022313-2675sjlf	363	40	glycosylation	glycosylation	NN
cord-022313-2675sjlf	363	41	.	.	.
cord-022313-2675sjlf	364	1	Instead	instead	RB
cord-022313-2675sjlf	364	2	,	,	,
cord-022313-2675sjlf	364	3	such	such	JJ
cord-022313-2675sjlf	364	4	cells	cell	NNS
cord-022313-2675sjlf	364	5	produce	produce	VBP
cord-022313-2675sjlf	364	6	a	a	DT
cord-022313-2675sjlf	364	7	truncated	truncated	JJ
cord-022313-2675sjlf	364	8	lipid	lipid	NN
cord-022313-2675sjlf	364	9	-	-	HYPH
cord-022313-2675sjlf	364	10	linked	link	VBN
cord-022313-2675sjlf	364	11	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	364	12	that	that	WDT
cord-022313-2675sjlf	364	13	is	be	VBZ
cord-022313-2675sjlf	364	14	a	a	DT
cord-022313-2675sjlf	364	15	Man	man	NN
cord-022313-2675sjlf	364	16	5	5	CD
cord-022313-2675sjlf	364	17	(	(	-LRB-
cord-022313-2675sjlf	364	18	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	364	19	)	)	-RRB-
cord-022313-2675sjlf	364	20	2	2	CD
cord-022313-2675sjlf	364	21	-PP	-PP	NNS
cord-022313-2675sjlf	364	22	-	-	HYPH
cord-022313-2675sjlf	364	23	dolichol	dolichol	JJ
cord-022313-2675sjlf	364	24	(	(	-LRB-
cord-022313-2675sjlf	364	25	i.e.	i.e.	FW
cord-022313-2675sjlf	364	26	,	,	,
cord-022313-2675sjlf	364	27	Manal,2Manal,2Manal,3[Manal,6	manal,2manal,2manal,3[manal,6	NN
cord-022313-2675sjlf	364	28	]	]	-RRB-
cord-022313-2675sjlf	364	29	Man/31,4GlcNAc/31,4GlcNAc-	Man/31,4GlcNAc/31,4GlcNAc-	NNP
cord-022313-2675sjlf	364	30	)	)	-RRB-
cord-022313-2675sjlf	364	31	and	and	CC
cord-022313-2675sjlf	364	32	then	then	RB
cord-022313-2675sjlf	364	33	glucosylate	glucosylate	NNP
cord-022313-2675sjlf	364	34	this	this	DT
cord-022313-2675sjlf	364	35	intermediate	intermediate	JJ
cord-022313-2675sjlf	364	36	to	to	TO
cord-022313-2675sjlf	364	37	produce	produce	VB
cord-022313-2675sjlf	364	38	a	a	DT
cord-022313-2675sjlf	364	39	Glc	Glc	NNP
cord-022313-2675sjlf	364	40	3	3	CD
cord-022313-2675sjlf	364	41	Man	Man	NNP
cord-022313-2675sjlf	364	42	5	5	CD
cord-022313-2675sjlf	364	43	(	(	-LRB-
cord-022313-2675sjlf	364	44	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	364	45	)	)	-RRB-
cord-022313-2675sjlf	364	46	2	2	CD
cord-022313-2675sjlf	364	47	-PP	-PP	NNS
cord-022313-2675sjlf	364	48	-	-	HYPH
cord-022313-2675sjlf	364	49	dolichol	dolichol	JJ
cord-022313-2675sjlf	364	50	(	(	-LRB-
cord-022313-2675sjlf	364	51	159	159	CD
cord-022313-2675sjlf	364	52	)	)	-RRB-
cord-022313-2675sjlf	364	53	(	(	-LRB-
cord-022313-2675sjlf	364	54	160	160	CD
cord-022313-2675sjlf	364	55	)	)	-RRB-
cord-022313-2675sjlf	364	56	(	(	-LRB-
cord-022313-2675sjlf	364	57	161	161	CD
cord-022313-2675sjlf	364	58	)	)	-RRB-
cord-022313-2675sjlf	364	59	.	.	.
cord-022313-2675sjlf	365	1	It	-PRON-	PRP
cord-022313-2675sjlf	365	2	appears	appear	VBZ
cord-022313-2675sjlf	365	3	that	that	IN
cord-022313-2675sjlf	365	4	under	under	IN
cord-022313-2675sjlf	365	5	glucose	glucose	NN
cord-022313-2675sjlf	365	6	starvation	starvation	NN
cord-022313-2675sjlf	365	7	conditions	condition	NNS
cord-022313-2675sjlf	365	8	,	,	,
cord-022313-2675sjlf	365	9	the	the	DT
cord-022313-2675sjlf	365	10	cells	cell	NNS
cord-022313-2675sjlf	365	11	are	be	VBP
cord-022313-2675sjlf	365	12	not	not	RB
cord-022313-2675sjlf	365	13	able	able	JJ
cord-022313-2675sjlf	365	14	to	to	TO
cord-022313-2675sjlf	365	15	synthesize	synthesize	VB
cord-022313-2675sjlf	365	16	dolichyl	dolichyl	NN
cord-022313-2675sjlf	365	17	-	-	HYPH
cord-022313-2675sjlf	365	18	P	p	NN
cord-022313-2675sjlf	365	19	-	-	HYPH
cord-022313-2675sjlf	365	20	mannose	mannose	NN
cord-022313-2675sjlf	365	21	,	,	,
cord-022313-2675sjlf	365	22	but	but	CC
cord-022313-2675sjlf	365	23	the	the	DT
cord-022313-2675sjlf	365	24	reason	reason	NN
cord-022313-2675sjlf	365	25	for	for	IN
cord-022313-2675sjlf	365	26	this	this	DT
cord-022313-2675sjlf	365	27	lesion	lesion	NN
cord-022313-2675sjlf	365	28	is	be	VBZ
cord-022313-2675sjlf	365	29	not	not	RB
cord-022313-2675sjlf	365	30	clear	clear	JJ
cord-022313-2675sjlf	365	31	because	because	IN
cord-022313-2675sjlf	365	32	these	these	DT
cord-022313-2675sjlf	365	33	cells	cell	NNS
cord-022313-2675sjlf	365	34	still	still	RB
cord-022313-2675sjlf	365	35	do	do	VBP
cord-022313-2675sjlf	365	36	make	make	VB
cord-022313-2675sjlf	365	37	dolichyl	dolichyl	NN
cord-022313-2675sjlf	365	38	-	-	HYPH
cord-022313-2675sjlf	365	39	P	p	NN
cord-022313-2675sjlf	365	40	-	-	HYPH
cord-022313-2675sjlf	365	41	glucose	glucose	NN
cord-022313-2675sjlf	365	42	and	and	CC
cord-022313-2675sjlf	365	43	appear	appear	VBP
cord-022313-2675sjlf	365	44	to	to	TO
cord-022313-2675sjlf	365	45	glucosylate	glucosylate	VB
cord-022313-2675sjlf	365	46	the	the	DT
cord-022313-2675sjlf	365	47	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	365	48	.	.	.
cord-022313-2675sjlf	366	1	In	in	IN
cord-022313-2675sjlf	366	2	several	several	JJ
cord-022313-2675sjlf	366	3	cell	cell	NN
cord-022313-2675sjlf	366	4	lines	line	NNS
cord-022313-2675sjlf	366	5	,	,	,
cord-022313-2675sjlf	366	6	the	the	DT
cord-022313-2675sjlf	366	7	effect	effect	NN
cord-022313-2675sjlf	366	8	of	of	IN
cord-022313-2675sjlf	366	9	glucose	glucose	NN
cord-022313-2675sjlf	366	10	starva	starva	NNP
cord-022313-2675sjlf	366	11	tion	tion	NN
cord-022313-2675sjlf	366	12	was	be	VBD
cord-022313-2675sjlf	366	13	seen	see	VBN
cord-022313-2675sjlf	366	14	within	within	IN
cord-022313-2675sjlf	366	15	20	20	CD
cord-022313-2675sjlf	366	16	min	min	NN
cord-022313-2675sjlf	366	17	after	after	IN
cord-022313-2675sjlf	366	18	the	the	DT
cord-022313-2675sjlf	366	19	removal	removal	NN
cord-022313-2675sjlf	366	20	of	of	IN
cord-022313-2675sjlf	366	21	glucose	glucose	NN
cord-022313-2675sjlf	366	22	,	,	,
cord-022313-2675sjlf	366	23	as	as	RB
cord-022313-2675sjlf	366	24	long	long	RB
cord-022313-2675sjlf	366	25	as	as	IN
cord-022313-2675sjlf	366	26	the	the	DT
cord-022313-2675sjlf	366	27	cells	cell	NNS
cord-022313-2675sjlf	366	28	were	be	VBD
cord-022313-2675sjlf	366	29	at	at	IN
cord-022313-2675sjlf	366	30	low	low	JJ
cord-022313-2675sjlf	366	31	to	to	IN
cord-022313-2675sjlf	366	32	moderate	moderate	JJ
cord-022313-2675sjlf	366	33	density	density	NN
cord-022313-2675sjlf	366	34	,	,	,
cord-022313-2675sjlf	366	35	but	but	CC
cord-022313-2675sjlf	366	36	at	at	IN
cord-022313-2675sjlf	366	37	high	high	JJ
cord-022313-2675sjlf	366	38	density	density	NN
cord-022313-2675sjlf	366	39	no	no	DT
cord-022313-2675sjlf	366	40	effect	effect	NN
cord-022313-2675sjlf	366	41	was	be	VBD
cord-022313-2675sjlf	366	42	seen	see	VBN
cord-022313-2675sjlf	366	43	(	(	-LRB-
cord-022313-2675sjlf	366	44	162	162	CD
cord-022313-2675sjlf	366	45	)	)	-RRB-
cord-022313-2675sjlf	366	46	.	.	.
cord-022313-2675sjlf	367	1	The	the	DT
cord-022313-2675sjlf	367	2	glucose	glucose	NN
cord-022313-2675sjlf	367	3	starvation	starvation	NN
cord-022313-2675sjlf	367	4	phenomenon	phenomenon	NN
cord-022313-2675sjlf	367	5	could	could	MD
cord-022313-2675sjlf	367	6	be	be	VB
cord-022313-2675sjlf	367	7	overcome	overcome	VBN
cord-022313-2675sjlf	367	8	by	by	IN
cord-022313-2675sjlf	367	9	the	the	DT
cord-022313-2675sjlf	367	10	addition	addition	NN
cord-022313-2675sjlf	367	11	of	of	IN
cord-022313-2675sjlf	367	12	glucose	glucose	NN
cord-022313-2675sjlf	367	13	,	,	,
cord-022313-2675sjlf	367	14	but	but	CC
cord-022313-2675sjlf	367	15	not	not	RB
cord-022313-2675sjlf	367	16	the	the	DT
cord-022313-2675sjlf	367	17	addition	addition	NN
cord-022313-2675sjlf	367	18	of	of	IN
cord-022313-2675sjlf	367	19	galactose	galactose	NN
cord-022313-2675sjlf	367	20	,	,	,
cord-022313-2675sjlf	367	21	glutamine	glutamine	NN
cord-022313-2675sjlf	367	22	,	,	,
cord-022313-2675sjlf	367	23	pyruvate	pyruvate	NN
cord-022313-2675sjlf	367	24	,	,	,
cord-022313-2675sjlf	367	25	inositol	inositol	NN
cord-022313-2675sjlf	367	26	,	,	,
cord-022313-2675sjlf	367	27	or	or	CC
cord-022313-2675sjlf	367	28	glycerol	glycerol	NN
cord-022313-2675sjlf	367	29	.	.	.
cord-022313-2675sjlf	368	1	In	in	IN
cord-022313-2675sjlf	368	2	rat	rat	NN
cord-022313-2675sjlf	368	3	hepatoma	hepatoma	NN
cord-022313-2675sjlf	368	4	cells	cell	NNS
cord-022313-2675sjlf	368	5	that	that	WDT
cord-022313-2675sjlf	368	6	were	be	VBD
cord-022313-2675sjlf	368	7	starved	starve	VBN
cord-022313-2675sjlf	368	8	for	for	IN
cord-022313-2675sjlf	368	9	glucose	glucose	NN
cord-022313-2675sjlf	368	10	,	,	,
cord-022313-2675sjlf	368	11	a	a	DT
cord-022313-2675sjlf	368	12	lower	low	JJR
cord-022313-2675sjlf	368	13	molecular	molecular	JJ
cord-022313-2675sjlf	368	14	weight	weight	NN
cord-022313-2675sjlf	368	15	form	form	NN
cord-022313-2675sjlf	368	16	of	of	IN
cord-022313-2675sjlf	368	17	a	a	DT
cord-022313-2675sjlf	368	18	r	r	NN
cord-022313-2675sjlf	368	19	acid	acid	NN
cord-022313-2675sjlf	368	20	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	368	21	was	be	VBD
cord-022313-2675sjlf	368	22	produced	produce	VBN
cord-022313-2675sjlf	368	23	and	and	CC
cord-022313-2675sjlf	368	24	this	this	DT
cord-022313-2675sjlf	368	25	decrease	decrease	NN
cord-022313-2675sjlf	368	26	in	in	IN
cord-022313-2675sjlf	368	27	molecular	molecular	JJ
cord-022313-2675sjlf	368	28	weight	weight	NN
cord-022313-2675sjlf	368	29	was	be	VBD
cord-022313-2675sjlf	368	30	due	due	JJ
cord-022313-2675sjlf	368	31	not	not	RB
cord-022313-2675sjlf	368	32	only	only	RB
cord-022313-2675sjlf	368	33	to	to	IN
cord-022313-2675sjlf	368	34	the	the	DT
cord-022313-2675sjlf	368	35	truncated	truncate	VBN
cord-022313-2675sjlf	368	36	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	368	37	,	,	,
cord-022313-2675sjlf	368	38	but	but	CC
cord-022313-2675sjlf	368	39	also	also	RB
cord-022313-2675sjlf	368	40	to	to	IN
cord-022313-2675sjlf	368	41	fewer	few	JJR
cord-022313-2675sjlf	368	42	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	368	43	chains	chain	NNS
cord-022313-2675sjlf	368	44	on	on	IN
cord-022313-2675sjlf	368	45	the	the	DT
cord-022313-2675sjlf	368	46	protein	protein	NN
cord-022313-2675sjlf	368	47	(	(	-LRB-
cord-022313-2675sjlf	368	48	163	163	CD
cord-022313-2675sjlf	368	49	)	)	-RRB-
cord-022313-2675sjlf	368	50	.	.	.
cord-022313-2675sjlf	369	1	Carbonyl	Carbonyl	NNP
cord-022313-2675sjlf	369	2	-	-	HYPH
cord-022313-2675sjlf	369	3	cyanide	cyanide	NN
cord-022313-2675sjlf	369	4	m	m	NN
cord-022313-2675sjlf	369	5	-	-	HYPH
cord-022313-2675sjlf	369	6	chlorophenylhydrazone	chlorophenylhydrazone	NNP
cord-022313-2675sjlf	369	7	(	(	-LRB-
cord-022313-2675sjlf	369	8	CCCP	CCCP	NNP
cord-022313-2675sjlf	369	9	)	)	-RRB-
cord-022313-2675sjlf	369	10	is	be	VBZ
cord-022313-2675sjlf	369	11	an	an	DT
cord-022313-2675sjlf	369	12	uncoupler	uncoupler	NN
cord-022313-2675sjlf	369	13	of	of	IN
cord-022313-2675sjlf	369	14	oxidative	oxidative	JJ
cord-022313-2675sjlf	369	15	phosphorylation	phosphorylation	NN
cord-022313-2675sjlf	369	16	that	that	WDT
cord-022313-2675sjlf	369	17	causes	cause	VBZ
cord-022313-2675sjlf	369	18	cells	cell	NNS
cord-022313-2675sjlf	369	19	to	to	TO
cord-022313-2675sjlf	369	20	be	be	VB
cord-022313-2675sjlf	369	21	depleted	deplete	VBN
cord-022313-2675sjlf	369	22	of	of	IN
cord-022313-2675sjlf	369	23	energy	energy	NN
cord-022313-2675sjlf	369	24	.	.	.
cord-022313-2675sjlf	370	1	When	when	WRB
cord-022313-2675sjlf	370	2	this	this	DT
cord-022313-2675sjlf	370	3	compound	compound	NN
cord-022313-2675sjlf	370	4	is	be	VBZ
cord-022313-2675sjlf	370	5	given	give	VBN
cord-022313-2675sjlf	370	6	to	to	IN
cord-022313-2675sjlf	370	7	various	various	JJ
cord-022313-2675sjlf	370	8	animal	animal	NN
cord-022313-2675sjlf	370	9	cells	cell	NNS
cord-022313-2675sjlf	370	10	,	,	,
cord-022313-2675sjlf	370	11	it	-PRON-	PRP
cord-022313-2675sjlf	370	12	causes	cause	VBZ
cord-022313-2675sjlf	370	13	a	a	DT
cord-022313-2675sjlf	370	14	similar	similar	JJ
cord-022313-2675sjlf	370	15	situation	situation	NN
cord-022313-2675sjlf	370	16	to	to	IN
cord-022313-2675sjlf	370	17	that	that	DT
cord-022313-2675sjlf	370	18	seen	see	VBN
cord-022313-2675sjlf	370	19	with	with	IN
cord-022313-2675sjlf	370	20	glucose	glucose	NN
cord-022313-2675sjlf	370	21	starvartion	starvartion	NN
cord-022313-2675sjlf	370	22	;	;	,
cord-022313-2675sjlf	370	23	i.e.	i.e.	FW
cord-022313-2675sjlf	370	24	,	,	,
cord-022313-2675sjlf	370	25	cells	cell	NNS
cord-022313-2675sjlf	370	26	are	be	VBP
cord-022313-2675sjlf	370	27	unable	unable	JJ
cord-022313-2675sjlf	370	28	to	to	TO
cord-022313-2675sjlf	370	29	produce	produce	VB
cord-022313-2675sjlf	370	30	dolichyl	dolichyl	NN
cord-022313-2675sjlf	370	31	-	-	HYPH
cord-022313-2675sjlf	370	32	P	p	NN
cord-022313-2675sjlf	370	33	-	-	HYPH
cord-022313-2675sjlf	370	34	mannose	mannose	NN
cord-022313-2675sjlf	370	35	,	,	,
cord-022313-2675sjlf	370	36	although	although	IN
cord-022313-2675sjlf	370	37	they	-PRON-	PRP
cord-022313-2675sjlf	370	38	still	still	RB
cord-022313-2675sjlf	370	39	synthesize	synthesize	VBP
cord-022313-2675sjlf	370	40	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	370	41	-	-	HYPH
cord-022313-2675sjlf	370	42	PP	PP	NNP
cord-022313-2675sjlf	370	43	-	-	HYPH
cord-022313-2675sjlf	370	44	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	370	45	and	and	CC
cord-022313-2675sjlf	370	46	dolichyl	dolichyl	NN
cord-022313-2675sjlf	370	47	-	-	HYPH
cord-022313-2675sjlf	370	48	P	p	NN
cord-022313-2675sjlf	370	49	-	-	HYPH
cord-022313-2675sjlf	370	50	glucose	glucose	NN
cord-022313-2675sjlf	370	51	.	.	.
cord-022313-2675sjlf	371	1	These	these	DT
cord-022313-2675sjlf	371	2	cells	cell	NNS
cord-022313-2675sjlf	371	3	form	form	VBP
cord-022313-2675sjlf	371	4	a	a	DT
cord-022313-2675sjlf	371	5	Glc	Glc	NNP
cord-022313-2675sjlf	371	6	3	3	CD
cord-022313-2675sjlf	371	7	Man	Man	NNP
cord-022313-2675sjlf	371	8	5	5	CD
cord-022313-2675sjlf	371	9	(	(	-LRB-
cord-022313-2675sjlf	371	10	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	371	11	)	)	-RRB-
cord-022313-2675sjlf	371	12	2	2	CD
cord-022313-2675sjlf	371	13	-PP	-PP	NNS
cord-022313-2675sjlf	371	14	-	-	HYPH
cord-022313-2675sjlf	371	15	dolichol	dolichol	JJ
cord-022313-2675sjlf	371	16	and	and	CC
cord-022313-2675sjlf	371	17	transfer	transfer	VB
cord-022313-2675sjlf	371	18	this	this	DT
cord-022313-2675sjlf	371	19	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	371	20	to	to	IN
cord-022313-2675sjlf	371	21	protein	protein	NN
cord-022313-2675sjlf	371	22	(	(	-LRB-
cord-022313-2675sjlf	371	23	164	164	CD
cord-022313-2675sjlf	371	24	)	)	-RRB-
cord-022313-2675sjlf	371	25	.	.	.
cord-022313-2675sjlf	372	1	On	on	IN
cord-022313-2675sjlf	372	2	the	the	DT
cord-022313-2675sjlf	372	3	other	other	JJ
cord-022313-2675sjlf	372	4	hand	hand	NN
cord-022313-2675sjlf	372	5	,	,	,
cord-022313-2675sjlf	372	6	in	in	IN
cord-022313-2675sjlf	372	7	thyroid	thyroid	JJ
cord-022313-2675sjlf	372	8	slices	slice	NNS
cord-022313-2675sjlf	372	9	incubated	incubate	VBN
cord-022313-2675sjlf	372	10	with	with	IN
cord-022313-2675sjlf	372	11	CCCP	CCCP	NNP
cord-022313-2675sjlf	372	12	,	,	,
cord-022313-2675sjlf	372	13	Man	Man	NNP
cord-022313-2675sjlf	372	14	9	9	CD
cord-022313-2675sjlf	372	15	.	.	.
cord-022313-2675sjlf	372	16	8	8	CD
cord-022313-2675sjlf	372	17	(	(	-LRB-
cord-022313-2675sjlf	372	18	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	372	19	)	)	-RRB-
cord-022313-2675sjlf	372	20	2	2	CD
cord-022313-2675sjlf	372	21	-PP	-pp	JJ
cord-022313-2675sjlf	372	22	-	-	HYPH
cord-022313-2675sjlf	372	23	dolichol	dolichol	JJ
cord-022313-2675sjlf	372	24	intermediates	intermediate	NNS
cord-022313-2675sjlf	372	25	were	be	VBD
cord-022313-2675sjlf	372	26	produced	produce	VBN
cord-022313-2675sjlf	372	27	,	,	,
cord-022313-2675sjlf	372	28	and	and	CC
cord-022313-2675sjlf	372	29	a	a	DT
cord-022313-2675sjlf	372	30	decrease	decrease	NN
cord-022313-2675sjlf	372	31	in	in	IN
cord-022313-2675sjlf	372	32	N	n	CD
cord-022313-2675sjlf	372	33	-	-	HYPH
cord-022313-2675sjlf	372	34	linked	link	VBN
cord-022313-2675sjlf	372	35	glycosylation	glycosylation	NN
cord-022313-2675sjlf	372	36	was	be	VBD
cord-022313-2675sjlf	372	37	observed	observe	VBN
cord-022313-2675sjlf	372	38	(	(	-LRB-
cord-022313-2675sjlf	372	39	165	165	CD
cord-022313-2675sjlf	372	40	)	)	-RRB-
cord-022313-2675sjlf	372	41	.	.	.
cord-022313-2675sjlf	373	1	In	in	IN
cord-022313-2675sjlf	373	2	this	this	DT
cord-022313-2675sjlf	373	3	study	study	NN
cord-022313-2675sjlf	373	4	,	,	,
cord-022313-2675sjlf	373	5	other	other	JJ
cord-022313-2675sjlf	373	6	inhibi	inhibi	NNP
cord-022313-2675sjlf	373	7	tors	tor	NNS
cord-022313-2675sjlf	373	8	of	of	IN
cord-022313-2675sjlf	373	9	respiration	respiration	NN
cord-022313-2675sjlf	373	10	such	such	JJ
cord-022313-2675sjlf	373	11	as	as	IN
cord-022313-2675sjlf	373	12	N	n	CD
cord-022313-2675sjlf	373	13	2	2	CD
cord-022313-2675sjlf	373	14	or	or	CC
cord-022313-2675sjlf	373	15	antimycin	antimycin	NNS
cord-022313-2675sjlf	373	16	A	a	DT
cord-022313-2675sjlf	373	17	caused	cause	VBD
cord-022313-2675sjlf	373	18	the	the	DT
cord-022313-2675sjlf	373	19	same	same	JJ
cord-022313-2675sjlf	373	20	effects	effect	NNS
cord-022313-2675sjlf	373	21	.	.	.
cord-022313-2675sjlf	374	1	Since	since	IN
cord-022313-2675sjlf	374	2	some	some	DT
cord-022313-2675sjlf	374	3	uncouplers	uncoupler	NNS
cord-022313-2675sjlf	374	4	of	of	IN
cord-022313-2675sjlf	374	5	oxidative	oxidative	JJ
cord-022313-2675sjlf	374	6	phosphorylation	phosphorylation	NN
cord-022313-2675sjlf	374	7	have	have	VBP
cord-022313-2675sjlf	374	8	been	be	VBN
cord-022313-2675sjlf	374	9	reported	report	VBN
cord-022313-2675sjlf	374	10	to	to	TO
cord-022313-2675sjlf	374	11	disrupt	disrupt	VB
cord-022313-2675sjlf	374	12	the	the	DT
cord-022313-2675sjlf	374	13	recycling	recycling	NN
cord-022313-2675sjlf	374	14	of	of	IN
cord-022313-2675sjlf	374	15	the	the	DT
cord-022313-2675sjlf	374	16	glucose	glucose	NN
cord-022313-2675sjlf	374	17	transporter	transporter	NN
cord-022313-2675sjlf	374	18	,	,	,
cord-022313-2675sjlf	374	19	these	these	DT
cord-022313-2675sjlf	374	20	compounds	compound	NNS
cord-022313-2675sjlf	374	21	may	may	MD
cord-022313-2675sjlf	374	22	limit	limit	VB
cord-022313-2675sjlf	374	23	the	the	DT
cord-022313-2675sjlf	374	24	entry	entry	NN
cord-022313-2675sjlf	374	25	of	of	IN
cord-022313-2675sjlf	374	26	glucose	glucose	NN
cord-022313-2675sjlf	374	27	into	into	IN
cord-022313-2675sjlf	374	28	the	the	DT
cord-022313-2675sjlf	374	29	cells	cell	NNS
cord-022313-2675sjlf	374	30	,	,	,
cord-022313-2675sjlf	374	31	thus	thus	RB
cord-022313-2675sjlf	374	32	mimicking	mimic	VBG
cord-022313-2675sjlf	374	33	the	the	DT
cord-022313-2675sjlf	374	34	glucose	glucose	NN
cord-022313-2675sjlf	374	35	starvation	starvation	NN
cord-022313-2675sjlf	374	36	effect	effect	NN
cord-022313-2675sjlf	374	37	.	.	.
cord-022313-2675sjlf	375	1	The	the	DT
cord-022313-2675sjlf	375	2	puzzle	puzzle	NN
cord-022313-2675sjlf	375	3	here	here	RB
cord-022313-2675sjlf	375	4	is	be	VBZ
cord-022313-2675sjlf	375	5	the	the	DT
cord-022313-2675sjlf	375	6	same	same	JJ
cord-022313-2675sjlf	375	7	as	as	IN
cord-022313-2675sjlf	375	8	that	that	DT
cord-022313-2675sjlf	375	9	mentioned	mention	VBD
cord-022313-2675sjlf	375	10	earlier	early	RBR
cord-022313-2675sjlf	375	11	;	;	,
cord-022313-2675sjlf	375	12	i.e.	i.e.	FW
cord-022313-2675sjlf	375	13	,	,	,
cord-022313-2675sjlf	375	14	Why	why	WRB
cord-022313-2675sjlf	375	15	is	be	VBZ
cord-022313-2675sjlf	375	16	the	the	DT
cord-022313-2675sjlf	375	17	formation	formation	NN
cord-022313-2675sjlf	375	18	of	of	IN
cord-022313-2675sjlf	375	19	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	375	20	-	-	HYPH
cord-022313-2675sjlf	375	21	P	p	NN
cord-022313-2675sjlf	375	22	-	-	HYPH
cord-022313-2675sjlf	375	23	mannose	mannose	NN
cord-022313-2675sjlf	375	24	inhibited	inhibit	VBN
cord-022313-2675sjlf	375	25	,	,	,
cord-022313-2675sjlf	375	26	but	but	CC
cord-022313-2675sjlf	375	27	not	not	RB
cord-022313-2675sjlf	375	28	that	that	DT
cord-022313-2675sjlf	375	29	of	of	IN
cord-022313-2675sjlf	375	30	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	375	31	-	-	HYPH
cord-022313-2675sjlf	375	32	P	p	NN
cord-022313-2675sjlf	375	33	-	-	HYPH
cord-022313-2675sjlf	375	34	glucose	glucose	NN
cord-022313-2675sjlf	375	35	?	?	.
cord-022313-2675sjlf	376	1	Perhaps	perhaps	RB
cord-022313-2675sjlf	376	2	it	-PRON-	PRP
cord-022313-2675sjlf	376	3	could	could	MD
cord-022313-2675sjlf	376	4	have	have	VB
cord-022313-2675sjlf	376	5	something	something	NN
cord-022313-2675sjlf	376	6	to	to	TO
cord-022313-2675sjlf	376	7	do	do	VB
cord-022313-2675sjlf	376	8	with	with	IN
cord-022313-2675sjlf	376	9	the	the	DT
cord-022313-2675sjlf	376	10	postulation	postulation	NN
cord-022313-2675sjlf	376	11	that	that	IN
cord-022313-2675sjlf	376	12	the	the	DT
cord-022313-2675sjlf	376	13	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	376	14	-	-	HYPH
cord-022313-2675sjlf	376	15	P	p	NN
cord-022313-2675sjlf	376	16	-	-	HYPH
cord-022313-2675sjlf	376	17	mannose	mannose	NN
cord-022313-2675sjlf	376	18	synthase	synthase	NN
cord-022313-2675sjlf	376	19	is	be	VBZ
cord-022313-2675sjlf	376	20	a	a	DT
cord-022313-2675sjlf	376	21	regulatory	regulatory	JJ
cord-022313-2675sjlf	376	22	en	en	IN
cord-022313-2675sjlf	376	23	zyme	zyme	NNP
cord-022313-2675sjlf	376	24	and	and	CC
cord-022313-2675sjlf	376	25	the	the	DT
cord-022313-2675sjlf	376	26	protein	protein	NN
cord-022313-2675sjlf	376	27	itself	-PRON-	PRP
cord-022313-2675sjlf	376	28	undergoes	undergo	VBZ
cord-022313-2675sjlf	376	29	phosphorylation	phosphorylation	NN
cord-022313-2675sjlf	376	30	under	under	IN
cord-022313-2675sjlf	376	31	some	some	DT
cord-022313-2675sjlf	376	32	conditions	condition	NNS
cord-022313-2675sjlf	376	33	.	.	.
cord-022313-2675sjlf	377	1	A	a	DT
cord-022313-2675sjlf	377	2	number	number	NN
cord-022313-2675sjlf	377	3	of	of	IN
cord-022313-2675sjlf	377	4	naturally	naturally	RB
cord-022313-2675sjlf	377	5	occurring	occur	VBG
cord-022313-2675sjlf	377	6	,	,	,
cord-022313-2675sjlf	377	7	sugarlike	sugarlike	JJ
cord-022313-2675sjlf	377	8	compounds	compound	NNS
cord-022313-2675sjlf	377	9	in	in	IN
cord-022313-2675sjlf	377	10	which	which	WDT
cord-022313-2675sjlf	377	11	the	the	DT
cord-022313-2675sjlf	377	12	ring	ring	NN
cord-022313-2675sjlf	377	13	oxygen	oxygen	NN
cord-022313-2675sjlf	377	14	is	be	VBZ
cord-022313-2675sjlf	377	15	replaced	replace	VBN
cord-022313-2675sjlf	377	16	by	by	IN
cord-022313-2675sjlf	377	17	a	a	DT
cord-022313-2675sjlf	377	18	nitrogen	nitrogen	NN
cord-022313-2675sjlf	377	19	have	have	VBP
cord-022313-2675sjlf	377	20	been	be	VBN
cord-022313-2675sjlf	377	21	isolated	isolate	VBN
cord-022313-2675sjlf	377	22	,	,	,
cord-022313-2675sjlf	377	23	and	and	CC
cord-022313-2675sjlf	377	24	these	these	DT
cord-022313-2675sjlf	377	25	alkaloids	alkaloid	NNS
cord-022313-2675sjlf	377	26	have	have	VBP
cord-022313-2675sjlf	377	27	been	be	VBN
cord-022313-2675sjlf	377	28	found	find	VBN
cord-022313-2675sjlf	377	29	to	to	TO
cord-022313-2675sjlf	377	30	be	be	VB
cord-022313-2675sjlf	377	31	potent	potent	JJ
cord-022313-2675sjlf	377	32	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	377	33	of	of	IN
cord-022313-2675sjlf	377	34	various	various	JJ
cord-022313-2675sjlf	377	35	glycosidases	glycosidase	NNS
cord-022313-2675sjlf	377	36	.	.	.
cord-022313-2675sjlf	378	1	Apparantly	apparantly	RB
cord-022313-2675sjlf	378	2	this	this	DT
cord-022313-2675sjlf	378	3	nitrogen	nitrogen	NN
cord-022313-2675sjlf	378	4	in	in	IN
cord-022313-2675sjlf	378	5	the	the	DT
cord-022313-2675sjlf	378	6	ring	ring	NN
cord-022313-2675sjlf	378	7	makes	make	VBZ
cord-022313-2675sjlf	378	8	these	these	DT
cord-022313-2675sjlf	378	9	compounds	compound	NNS
cord-022313-2675sjlf	378	10	inactive	inactive	JJ
cord-022313-2675sjlf	378	11	from	from	IN
cord-022313-2675sjlf	378	12	a	a	DT
cord-022313-2675sjlf	378	13	metabolic	metabolic	JJ
cord-022313-2675sjlf	378	14	standpoint	standpoint	NN
cord-022313-2675sjlf	378	15	,	,	,
cord-022313-2675sjlf	378	16	but	but	CC
cord-022313-2675sjlf	378	17	they	-PRON-	PRP
cord-022313-2675sjlf	378	18	are	be	VBP
cord-022313-2675sjlf	378	19	still	still	RB
cord-022313-2675sjlf	378	20	recognized	recognize	VBN
cord-022313-2675sjlf	378	21	by	by	IN
cord-022313-2675sjlf	378	22	specific	specific	JJ
cord-022313-2675sjlf	378	23	glycosidases	glycosidase	NNS
cord-022313-2675sjlf	378	24	and	and	CC
cord-022313-2675sjlf	378	25	therefore	therefore	RB
cord-022313-2675sjlf	378	26	function	function	VBP
cord-022313-2675sjlf	378	27	as	as	IN
cord-022313-2675sjlf	378	28	useful	useful	JJ
cord-022313-2675sjlf	378	29	enzyme	enzyme	NN
cord-022313-2675sjlf	378	30	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	378	31	.	.	.
cord-022313-2675sjlf	379	1	Because	because	IN
cord-022313-2675sjlf	379	2	the	the	DT
cord-022313-2675sjlf	379	3	enzymes	enzyme	NNS
cord-022313-2675sjlf	379	4	involved	involve	VBN
cord-022313-2675sjlf	379	5	in	in	IN
cord-022313-2675sjlf	379	6	the	the	DT
cord-022313-2675sjlf	379	7	early	early	JJ
cord-022313-2675sjlf	379	8	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	379	9	processing	processing	NN
cord-022313-2675sjlf	379	10	reactions	reaction	NNS
cord-022313-2675sjlf	379	11	are	be	VBP
cord-022313-2675sjlf	379	12	glycosidases	glycosidase	NNS
cord-022313-2675sjlf	379	13	,	,	,
cord-022313-2675sjlf	379	14	these	these	DT
cord-022313-2675sjlf	379	15	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	379	16	have	have	VBP
cord-022313-2675sjlf	379	17	played	play	VBN
cord-022313-2675sjlf	379	18	a	a	DT
cord-022313-2675sjlf	379	19	significant	significant	JJ
cord-022313-2675sjlf	379	20	role	role	NN
cord-022313-2675sjlf	379	21	in	in	IN
cord-022313-2675sjlf	379	22	studying	study	VBG
cord-022313-2675sjlf	379	23	the	the	DT
cord-022313-2675sjlf	379	24	sequence	sequence	NN
cord-022313-2675sjlf	379	25	of	of	IN
cord-022313-2675sjlf	379	26	reactions	reaction	NNS
cord-022313-2675sjlf	379	27	of	of	IN
cord-022313-2675sjlf	379	28	N	n	CD
cord-022313-2675sjlf	379	29	-	-	HYPH
cord-022313-2675sjlf	379	30	linked	link	VBN
cord-022313-2675sjlf	379	31	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	379	32	,	,	,
cord-022313-2675sjlf	379	33	as	as	RB
cord-022313-2675sjlf	379	34	well	well	RB
cord-022313-2675sjlf	379	35	as	as	IN
cord-022313-2675sjlf	379	36	the	the	DT
cord-022313-2675sjlf	379	37	requirement	requirement	NN
cord-022313-2675sjlf	379	38	for	for	IN
cord-022313-2675sjlf	379	39	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	379	40	processing	processing	NN
cord-022313-2675sjlf	379	41	in	in	IN
cord-022313-2675sjlf	379	42	many	many	JJ
cord-022313-2675sjlf	379	43	animal	animal	NN
cord-022313-2675sjlf	379	44	cell	cell	NN
cord-022313-2675sjlf	379	45	lines	line	NNS
cord-022313-2675sjlf	379	46	.	.	.
cord-022313-2675sjlf	380	1	Many	many	JJ
cord-022313-2675sjlf	380	2	of	of	IN
cord-022313-2675sjlf	380	3	these	these	DT
cord-022313-2675sjlf	380	4	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	380	5	have	have	VBP
cord-022313-2675sjlf	380	6	been	be	VBN
cord-022313-2675sjlf	380	7	isolated	isolate	VBN
cord-022313-2675sjlf	380	8	from	from	IN
cord-022313-2675sjlf	380	9	plant	plant	NN
cord-022313-2675sjlf	380	10	sources	source	NNS
cord-022313-2675sjlf	380	11	,	,	,
cord-022313-2675sjlf	380	12	but	but	CC
cord-022313-2675sjlf	380	13	the	the	DT
cord-022313-2675sjlf	380	14	characterization	characterization	NN
cord-022313-2675sjlf	380	15	of	of	IN
cord-022313-2675sjlf	380	16	their	-PRON-	PRP$
cord-022313-2675sjlf	380	17	structures	structure	NNS
cord-022313-2675sjlf	380	18	and	and	CC
cord-022313-2675sjlf	380	19	the	the	DT
cord-022313-2675sjlf	380	20	demonstra	demonstra	NNP
cord-022313-2675sjlf	380	21	tion	tion	NN
cord-022313-2675sjlf	380	22	of	of	IN
cord-022313-2675sjlf	380	23	their	-PRON-	PRP$
cord-022313-2675sjlf	380	24	biological	biological	JJ
cord-022313-2675sjlf	380	25	activity	activity	NN
cord-022313-2675sjlf	380	26	have	have	VBP
cord-022313-2675sjlf	380	27	stimulated	stimulate	VBN
cord-022313-2675sjlf	380	28	the	the	DT
cord-022313-2675sjlf	380	29	chemical	chemical	JJ
cord-022313-2675sjlf	380	30	synthesis	synthesis	NN
cord-022313-2675sjlf	380	31	of	of	IN
cord-022313-2675sjlf	380	32	a	a	DT
cord-022313-2675sjlf	380	33	number	number	NN
cord-022313-2675sjlf	380	34	of	of	IN
cord-022313-2675sjlf	380	35	other	other	JJ
cord-022313-2675sjlf	380	36	analogues	analogue	NNS
cord-022313-2675sjlf	380	37	.	.	.
cord-022313-2675sjlf	381	1	The	the	DT
cord-022313-2675sjlf	381	2	plant	plant	NN
cord-022313-2675sjlf	381	3	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	381	4	are	be	VBP
cord-022313-2675sjlf	381	5	all	all	DT
cord-022313-2675sjlf	381	6	alkaloids	alkaloid	NNS
cord-022313-2675sjlf	381	7	and	and	CC
cord-022313-2675sjlf	381	8	fall	fall	VB
cord-022313-2675sjlf	381	9	into	into	IN
cord-022313-2675sjlf	381	10	various	various	JJ
cord-022313-2675sjlf	381	11	chemical	chemical	NN
cord-022313-2675sjlf	381	12	classes	class	NNS
cord-022313-2675sjlf	381	13	designated	designate	VBN
cord-022313-2675sjlf	381	14	piperidines	piperidines	NNPS
cord-022313-2675sjlf	381	15	,	,	,
cord-022313-2675sjlf	381	16	pyrroli	pyrroli	NNP
cord-022313-2675sjlf	381	17	dines	dine	VBZ
cord-022313-2675sjlf	381	18	,	,	,
cord-022313-2675sjlf	381	19	indolizidines	indolizidine	NNS
cord-022313-2675sjlf	381	20	,	,	,
cord-022313-2675sjlf	381	21	and	and	CC
cord-022313-2675sjlf	381	22	pyrrolizidines	pyrrolizidines	NNP
cord-022313-2675sjlf	381	23	(	(	-LRB-
cord-022313-2675sjlf	381	24	166	166	CD
cord-022313-2675sjlf	381	25	)	)	-RRB-
cord-022313-2675sjlf	381	26	.	.	.
cord-022313-2675sjlf	382	1	Castanospermine	Castanospermine	NNP
cord-022313-2675sjlf	382	2	is	be	VBZ
cord-022313-2675sjlf	382	3	an	an	DT
cord-022313-2675sjlf	382	4	indolizidine	indolizidine	NN
cord-022313-2675sjlf	382	5	alkaloid	alkaloid	NN
cord-022313-2675sjlf	382	6	that	that	WDT
cord-022313-2675sjlf	382	7	is	be	VBZ
cord-022313-2675sjlf	382	8	found	find	VBN
cord-022313-2675sjlf	382	9	in	in	IN
cord-022313-2675sjlf	382	10	the	the	DT
cord-022313-2675sjlf	382	11	seeds	seed	NNS
cord-022313-2675sjlf	382	12	of	of	IN
cord-022313-2675sjlf	382	13	the	the	DT
cord-022313-2675sjlf	382	14	Australian	australian	JJ
cord-022313-2675sjlf	382	15	chestnut	chestnut	NN
cord-022313-2675sjlf	382	16	tree	tree	NN
cord-022313-2675sjlf	382	17	,	,	,
cord-022313-2675sjlf	382	18	Castanospermum	Castanospermum	NNP
cord-022313-2675sjlf	382	19	australe	australe	NNP
cord-022313-2675sjlf	382	20	(	(	-LRB-
cord-022313-2675sjlf	382	21	167	167	CD
cord-022313-2675sjlf	382	22	)	)	-RRB-
cord-022313-2675sjlf	382	23	.	.	.
cord-022313-2675sjlf	383	1	Its	-PRON-	PRP$
cord-022313-2675sjlf	383	2	structure	structure	NN
cord-022313-2675sjlf	383	3	is	be	VBZ
cord-022313-2675sjlf	383	4	shown	show	VBN
cord-022313-2675sjlf	383	5	in	in	IN
cord-022313-2675sjlf	383	6	Fig	Fig	NNP
cord-022313-2675sjlf	383	7	.	.	.
cord-022313-2675sjlf	384	1	9	9	LS
cord-022313-2675sjlf	384	2	.	.	.
cord-022313-2675sjlf	385	1	This	this	DT
cord-022313-2675sjlf	385	2	alkaloid	alkaloid	NN
cord-022313-2675sjlf	385	3	is	be	VBZ
cord-022313-2675sjlf	385	4	a	a	DT
cord-022313-2675sjlf	385	5	potent	potent	JJ
cord-022313-2675sjlf	385	6	inhibitor	inhibitor	NN
cord-022313-2675sjlf	385	7	of	of	IN
cord-022313-2675sjlf	385	8	βglucosidase	βglucosidase	NNP
cord-022313-2675sjlf	385	9	(	(	-LRB-
cord-022313-2675sjlf	385	10	168	168	CD
cord-022313-2675sjlf	385	11	)	)	-RRB-
cord-022313-2675sjlf	385	12	and	and	CC
cord-022313-2675sjlf	385	13	also	also	RB
cord-022313-2675sjlf	385	14	inhibits	inhibit	VBZ
cord-022313-2675sjlf	385	15	the	the	DT
cord-022313-2675sjlf	385	16	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	385	17	processing	processing	NN
cord-022313-2675sjlf	385	18	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	385	19	(	(	-LRB-
cord-022313-2675sjlf	385	20	I	i	NN
cord-022313-2675sjlf	385	21	and	and	CC
cord-022313-2675sjlf	385	22	II	II	NNP
cord-022313-2675sjlf	385	23	)	)	-RRB-
cord-022313-2675sjlf	385	24	,	,	,
cord-022313-2675sjlf	385	25	as	as	RB
cord-022313-2675sjlf	385	26	well	well	RB
cord-022313-2675sjlf	385	27	as	as	IN
cord-022313-2675sjlf	385	28	various	various	JJ
cord-022313-2675sjlf	385	29	other	other	JJ
cord-022313-2675sjlf	385	30	α	α	NN
cord-022313-2675sjlf	385	31	-	-	HYPH
cord-022313-2675sjlf	385	32	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	385	33	such	such	JJ
cord-022313-2675sjlf	385	34	as	as	IN
cord-022313-2675sjlf	385	35	sucrase	sucrase	NN
cord-022313-2675sjlf	385	36	,	,	,
cord-022313-2675sjlf	385	37	maltase	maltase	NNP
cord-022313-2675sjlf	385	38	,	,	,
cord-022313-2675sjlf	385	39	and	and	CC
cord-022313-2675sjlf	385	40	lysosomal	lysosomal	VBG
cord-022313-2675sjlf	385	41	a	a	DT
cord-022313-2675sjlf	385	42	-	-	HYPH
cord-022313-2675sjlf	385	43	glucosidase	glucosidase	NN
cord-022313-2675sjlf	385	44	(	(	-LRB-
cord-022313-2675sjlf	385	45	169	169	CD
cord-022313-2675sjlf	385	46	)	)	-RRB-
cord-022313-2675sjlf	385	47	.	.	.
cord-022313-2675sjlf	386	1	Because	because	IN
cord-022313-2675sjlf	386	2	this	this	DT
cord-022313-2675sjlf	386	3	compound	compound	NN
cord-022313-2675sjlf	386	4	Structures	structure	NNS
cord-022313-2675sjlf	386	5	of	of	IN
cord-022313-2675sjlf	386	6	various	various	JJ
cord-022313-2675sjlf	386	7	glucosidase	glucosidase	NN
cord-022313-2675sjlf	386	8	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	386	9	.	.	.
cord-022313-2675sjlf	387	1	Castanospermine	castanospermine	NN
cord-022313-2675sjlf	387	2	and	and	CC
cord-022313-2675sjlf	387	3	2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine	2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine	NN
cord-022313-2675sjlf	387	4	are	be	VBP
cord-022313-2675sjlf	387	5	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	387	6	of	of	IN
cord-022313-2675sjlf	387	7	both	both	DT
cord-022313-2675sjlf	387	8	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	387	9	I	I	NNP
cord-022313-2675sjlf	387	10	and	and	CC
cord-022313-2675sjlf	387	11	glucosi	glucosi	NNP
cord-022313-2675sjlf	387	12	dase	dase	NNP
cord-022313-2675sjlf	387	13	II	II	NNP
cord-022313-2675sjlf	387	14	,	,	,
cord-022313-2675sjlf	387	15	whereas	whereas	IN
cord-022313-2675sjlf	387	16	australine	australine	NN
cord-022313-2675sjlf	387	17	is	be	VBZ
cord-022313-2675sjlf	387	18	a	a	DT
cord-022313-2675sjlf	387	19	much	much	RB
cord-022313-2675sjlf	387	20	better	well	JJR
cord-022313-2675sjlf	387	21	inhibitor	inhibitor	NN
cord-022313-2675sjlf	387	22	of	of	IN
cord-022313-2675sjlf	387	23	glucosidase	glucosidase	NN
cord-022313-2675sjlf	387	24	I	-PRON-	PRP
cord-022313-2675sjlf	387	25	than	than	IN
cord-022313-2675sjlf	387	26	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	387	27	II	II	NNP
cord-022313-2675sjlf	387	28	and	and	CC
cord-022313-2675sjlf	387	29	MDL	MDL	NNP
cord-022313-2675sjlf	387	30	is	be	VBZ
cord-022313-2675sjlf	387	31	a	a	DT
cord-022313-2675sjlf	387	32	more	more	RBR
cord-022313-2675sjlf	387	33	potent	potent	JJ
cord-022313-2675sjlf	387	34	inhibitor	inhibitor	NN
cord-022313-2675sjlf	387	35	of	of	IN
cord-022313-2675sjlf	387	36	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	387	37	II	II	NNP
cord-022313-2675sjlf	387	38	.	.	.
cord-022313-2675sjlf	388	1	Lentiginosine	Lentiginosine	NNP
cord-022313-2675sjlf	388	2	,	,	,
cord-022313-2675sjlf	388	3	shown	show	VBN
cord-022313-2675sjlf	388	4	for	for	IN
cord-022313-2675sjlf	388	5	compari	compari	JJ
cord-022313-2675sjlf	388	6	son	son	NN
cord-022313-2675sjlf	388	7	,	,	,
cord-022313-2675sjlf	388	8	is	be	VBZ
cord-022313-2675sjlf	388	9	an	an	DT
cord-022313-2675sjlf	388	10	inhibitor	inhibitor	NN
cord-022313-2675sjlf	388	11	of	of	IN
cord-022313-2675sjlf	388	12	amyloglucosidase	amyloglucosidase	NN
cord-022313-2675sjlf	388	13	but	but	CC
cord-022313-2675sjlf	388	14	is	be	VBZ
cord-022313-2675sjlf	388	15	ineffective	ineffective	JJ
cord-022313-2675sjlf	388	16	against	against	IN
cord-022313-2675sjlf	388	17	the	the	DT
cord-022313-2675sjlf	388	18	processing	processing	NN
cord-022313-2675sjlf	388	19	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	388	20	.	.	.
cord-022313-2675sjlf	389	1	is	be	VBZ
cord-022313-2675sjlf	389	2	such	such	PDT
cord-022313-2675sjlf	389	3	a	a	DT
cord-022313-2675sjlf	389	4	strong	strong	JJ
cord-022313-2675sjlf	389	5	inhibitor	inhibitor	NN
cord-022313-2675sjlf	389	6	of	of	IN
cord-022313-2675sjlf	389	7	α	α	NN
cord-022313-2675sjlf	389	8	-	-	HYPH
cord-022313-2675sjlf	389	9	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	389	10	(	(	-LRB-
cord-022313-2675sjlf	389	11	such	such	JJ
cord-022313-2675sjlf	389	12	as	as	IN
cord-022313-2675sjlf	389	13	sucrase	sucrase	NN
cord-022313-2675sjlf	389	14	and	and	CC
cord-022313-2675sjlf	389	15	maltase	maltase	NNP
cord-022313-2675sjlf	389	16	)	)	-RRB-
cord-022313-2675sjlf	389	17	and	and	CC
cord-022313-2675sjlf	389	18	therefore	therefore	RB
cord-022313-2675sjlf	389	19	prevents	prevent	VBZ
cord-022313-2675sjlf	389	20	the	the	DT
cord-022313-2675sjlf	389	21	normal	normal	JJ
cord-022313-2675sjlf	389	22	digestion	digestion	NN
cord-022313-2675sjlf	389	23	of	of	IN
cord-022313-2675sjlf	389	24	starch	starch	NN
cord-022313-2675sjlf	389	25	and	and	CC
cord-022313-2675sjlf	389	26	sucrose	sucrose	NN
cord-022313-2675sjlf	389	27	,	,	,
cord-022313-2675sjlf	389	28	the	the	DT
cord-022313-2675sjlf	389	29	seeds	seed	NNS
cord-022313-2675sjlf	389	30	of	of	IN
cord-022313-2675sjlf	389	31	this	this	DT
cord-022313-2675sjlf	389	32	plant	plant	NN
cord-022313-2675sjlf	389	33	are	be	VBP
cord-022313-2675sjlf	389	34	toxic	toxic	JJ
cord-022313-2675sjlf	389	35	to	to	IN
cord-022313-2675sjlf	389	36	animals	animal	NNS
cord-022313-2675sjlf	389	37	and	and	CC
cord-022313-2675sjlf	389	38	cause	cause	VB
cord-022313-2675sjlf	389	39	severe	severe	JJ
cord-022313-2675sjlf	389	40	diarrhea	diarrhea	NN
cord-022313-2675sjlf	389	41	(	(	-LRB-
cord-022313-2675sjlf	389	42	170	170	CD
cord-022313-2675sjlf	389	43	)	)	-RRB-
cord-022313-2675sjlf	389	44	.	.	.
cord-022313-2675sjlf	390	1	When	when	WRB
cord-022313-2675sjlf	390	2	various	various	JJ
cord-022313-2675sjlf	390	3	cultured	cultured	JJ
cord-022313-2675sjlf	390	4	animal	animal	NN
cord-022313-2675sjlf	390	5	cells	cell	NNS
cord-022313-2675sjlf	390	6	are	be	VBP
cord-022313-2675sjlf	390	7	grown	grow	VBN
cord-022313-2675sjlf	390	8	or	or	CC
cord-022313-2675sjlf	390	9	incubated	incubate	VBN
cord-022313-2675sjlf	390	10	in	in	IN
cord-022313-2675sjlf	390	11	the	the	DT
cord-022313-2675sjlf	390	12	presence	presence	NN
cord-022313-2675sjlf	390	13	of	of	IN
cord-022313-2675sjlf	390	14	this	this	DT
cord-022313-2675sjlf	390	15	alkaloid	alkaloid	NN
cord-022313-2675sjlf	390	16	,	,	,
cord-022313-2675sjlf	390	17	the	the	DT
cord-022313-2675sjlf	390	18	processing	processing	NN
cord-022313-2675sjlf	390	19	of	of	IN
cord-022313-2675sjlf	390	20	N	n	CD
cord-022313-2675sjlf	390	21	-	-	HYPH
cord-022313-2675sjlf	390	22	linked	link	VBN
cord-022313-2675sjlf	390	23	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	390	24	is	be	VBZ
cord-022313-2675sjlf	390	25	blocked	block	VBN
cord-022313-2675sjlf	390	26	at	at	IN
cord-022313-2675sjlf	390	27	the	the	DT
cord-022313-2675sjlf	390	28	first	first	JJ
cord-022313-2675sjlf	390	29	step	step	NN
cord-022313-2675sjlf	390	30	in	in	IN
cord-022313-2675sjlf	390	31	the	the	DT
cord-022313-2675sjlf	390	32	pathway	pathway	NN
cord-022313-2675sjlf	390	33	(	(	-LRB-
cord-022313-2675sjlf	390	34	see	see	VB
cord-022313-2675sjlf	390	35	Fig	Fig	NNP
cord-022313-2675sjlf	390	36	.	.	.
cord-022313-2675sjlf	390	37	3	3	CD
cord-022313-2675sjlf	390	38	)	)	-RRB-
cord-022313-2675sjlf	390	39	,	,	,
cord-022313-2675sjlf	390	40	and	and	CC
cord-022313-2675sjlf	390	41	the	the	DT
cord-022313-2675sjlf	390	42	asparaginelinked	asparaginelinked	JJ
cord-022313-2675sjlf	390	43	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	390	44	have	have	VBP
cord-022313-2675sjlf	390	45	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	390	46	mostly	mostly	RB
cord-022313-2675sjlf	390	47	of	of	IN
cord-022313-2675sjlf	390	48	the	the	DT
cord-022313-2675sjlf	390	49	Glc	Glc	NNP
cord-022313-2675sjlf	390	50	3	3	CD
cord-022313-2675sjlf	390	51	Man	Man	NNP
cord-022313-2675sjlf	390	52	7	7	CD
cord-022313-2675sjlf	390	53	_	_	NN
cord-022313-2675sjlf	390	54	9	9	CD
cord-022313-2675sjlf	390	55	(	(	-LRB-
cord-022313-2675sjlf	390	56	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	390	57	)	)	-RRB-
cord-022313-2675sjlf	390	58	2	2	CD
cord-022313-2675sjlf	390	59	structure	structure	NN
cord-022313-2675sjlf	390	60	.	.	.
cord-022313-2675sjlf	391	1	Another	another	DT
cord-022313-2675sjlf	391	2	glucosidase	glucosidase	NN
cord-022313-2675sjlf	391	3	inhibitor	inhibitor	NN
cord-022313-2675sjlf	391	4	is	be	VBZ
cord-022313-2675sjlf	391	5	the	the	DT
cord-022313-2675sjlf	391	6	polyhydroxylated	polyhydroxylated	JJ
cord-022313-2675sjlf	391	7	piperidine	piperidine	JJ
cord-022313-2675sjlf	391	8	analog	analog	NN
cord-022313-2675sjlf	391	9	nojirimycin	nojirimycin	NNS
cord-022313-2675sjlf	391	10	,	,	,
cord-022313-2675sjlf	391	11	which	which	WDT
cord-022313-2675sjlf	391	12	corresponds	correspond	VBZ
cord-022313-2675sjlf	391	13	to	to	IN
cord-022313-2675sjlf	391	14	glucose	glucose	NN
cord-022313-2675sjlf	391	15	in	in	IN
cord-022313-2675sjlf	391	16	the	the	DT
cord-022313-2675sjlf	391	17	pyranose	pyranose	NN
cord-022313-2675sjlf	391	18	ring	ring	NN
cord-022313-2675sjlf	391	19	form	form	NN
cord-022313-2675sjlf	391	20	(	(	-LRB-
cord-022313-2675sjlf	391	21	see	see	VB
cord-022313-2675sjlf	391	22	Fig	Fig	NNP
cord-022313-2675sjlf	391	23	.	.	.
cord-022313-2675sjlf	391	24	9	9	CD
cord-022313-2675sjlf	391	25	)	)	-RRB-
cord-022313-2675sjlf	391	26	.	.	.
cord-022313-2675sjlf	392	1	This	this	DT
cord-022313-2675sjlf	392	2	compound	compound	NN
cord-022313-2675sjlf	392	3	was	be	VBD
cord-022313-2675sjlf	392	4	originally	originally	RB
cord-022313-2675sjlf	392	5	isolated	isolate	VBN
cord-022313-2675sjlf	392	6	from	from	IN
cord-022313-2675sjlf	392	7	Streptomyces	Streptomyces	NNP
cord-022313-2675sjlf	392	8	and	and	CC
cord-022313-2675sjlf	392	9	was	be	VBD
cord-022313-2675sjlf	392	10	found	find	VBN
cord-022313-2675sjlf	392	11	to	to	TO
cord-022313-2675sjlf	392	12	be	be	VB
cord-022313-2675sjlf	392	13	a	a	DT
cord-022313-2675sjlf	392	14	potent	potent	JJ
cord-022313-2675sjlf	392	15	inhibitor	inhibitor	NN
cord-022313-2675sjlf	392	16	of	of	IN
cord-022313-2675sjlf	392	17	a	a	DT
cord-022313-2675sjlf	392	18	-	-	:
cord-022313-2675sjlf	392	19	and	and	CC
cord-022313-2675sjlf	392	20	β	β	NN
cord-022313-2675sjlf	392	21	-	-	HYPH
cord-022313-2675sjlf	392	22	glucosidases	glucosidases	NNP
cord-022313-2675sjlf	392	23	(	(	-LRB-
cord-022313-2675sjlf	392	24	171	171	CD
cord-022313-2675sjlf	392	25	)	)	-RRB-
cord-022313-2675sjlf	392	26	.	.	.
cord-022313-2675sjlf	393	1	Chemical	chemical	JJ
cord-022313-2675sjlf	393	2	reduction	reduction	NN
cord-022313-2675sjlf	393	3	of	of	IN
cord-022313-2675sjlf	393	4	nojirimycin	nojirimycin	NNS
cord-022313-2675sjlf	393	5	gave	give	VBD
cord-022313-2675sjlf	393	6	the	the	DT
cord-022313-2675sjlf	393	7	more	more	RBR
cord-022313-2675sjlf	393	8	stable	stable	JJ
cord-022313-2675sjlf	393	9	deoxynojirimycin	deoxynojirimycin	NNS
cord-022313-2675sjlf	393	10	,	,	,
cord-022313-2675sjlf	393	11	which	which	WDT
cord-022313-2675sjlf	393	12	is	be	VBZ
cord-022313-2675sjlf	393	13	also	also	RB
cord-022313-2675sjlf	393	14	a	a	DT
cord-022313-2675sjlf	393	15	glucosidase	glucosidase	NN
cord-022313-2675sjlf	393	16	inhibitor	inhibitor	NN
cord-022313-2675sjlf	393	17	and	and	CC
cord-022313-2675sjlf	393	18	which	which	WDT
cord-022313-2675sjlf	393	19	has	have	VBZ
cord-022313-2675sjlf	393	20	subsequently	subsequently	RB
cord-022313-2675sjlf	393	21	been	be	VBN
cord-022313-2675sjlf	393	22	isolated	isolate	VBN
cord-022313-2675sjlf	393	23	from	from	IN
cord-022313-2675sjlf	393	24	bacteria	bacteria	NNS
cord-022313-2675sjlf	393	25	and	and	CC
cord-022313-2675sjlf	393	26	plants	plant	NNS
cord-022313-2675sjlf	393	27	(	(	-LRB-
cord-022313-2675sjlf	393	28	172	172	CD
cord-022313-2675sjlf	393	29	)	)	-RRB-
cord-022313-2675sjlf	393	30	.	.	.
cord-022313-2675sjlf	394	1	Deoxynojirimycin	Deoxynojirimycin	NNP
cord-022313-2675sjlf	394	2	causes	cause	VBZ
cord-022313-2675sjlf	394	3	the	the	DT
cord-022313-2675sjlf	394	4	same	same	JJ
cord-022313-2675sjlf	394	5	general	general	JJ
cord-022313-2675sjlf	394	6	effects	effect	NNS
cord-022313-2675sjlf	394	7	in	in	IN
cord-022313-2675sjlf	394	8	cell	cell	NN
cord-022313-2675sjlf	394	9	culture	culture	NN
cord-022313-2675sjlf	394	10	as	as	IN
cord-022313-2675sjlf	394	11	does	do	VBZ
cord-022313-2675sjlf	394	12	castanospermine	castanospermine	NN
cord-022313-2675sjlf	394	13	,	,	,
cord-022313-2675sjlf	394	14	although	although	IN
cord-022313-2675sjlf	394	15	it	-PRON-	PRP
cord-022313-2675sjlf	394	16	is	be	VBZ
cord-022313-2675sjlf	394	17	more	more	RBR
cord-022313-2675sjlf	394	18	active	active	JJ
cord-022313-2675sjlf	394	19	toward	toward	IN
cord-022313-2675sjlf	394	20	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	394	21	II	II	NNP
cord-022313-2675sjlf	394	22	than	than	IN
cord-022313-2675sjlf	394	23	toward	toward	IN
cord-022313-2675sjlf	394	24	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	394	25	I	I	NNP
cord-022313-2675sjlf	394	26	,	,	,
cord-022313-2675sjlf	394	27	and	and	CC
cord-022313-2675sjlf	394	28	it	-PRON-	PRP
cord-022313-2675sjlf	394	29	does	do	VBZ
cord-022313-2675sjlf	394	30	cause	cause	VB
cord-022313-2675sjlf	394	31	other	other	JJ
cord-022313-2675sjlf	394	32	alterations	alteration	NNS
cord-022313-2675sjlf	394	33	such	such	JJ
cord-022313-2675sjlf	394	34	as	as	IN
cord-022313-2675sjlf	394	35	changes	change	NNS
cord-022313-2675sjlf	394	36	in	in	IN
cord-022313-2675sjlf	394	37	the	the	DT
cord-022313-2675sjlf	394	38	structures	structure	NNS
cord-022313-2675sjlf	394	39	of	of	IN
cord-022313-2675sjlf	394	40	the	the	DT
cord-022313-2675sjlf	394	41	lipid	lipid	NN
cord-022313-2675sjlf	394	42	-	-	HYPH
cord-022313-2675sjlf	394	43	linked	link	VBN
cord-022313-2675sjlf	394	44	saccharides	saccharide	NNS
cord-022313-2675sjlf	394	45	(	(	-LRB-
cord-022313-2675sjlf	394	46	173	173	CD
cord-022313-2675sjlf	394	47	)	)	-RRB-
cord-022313-2675sjlf	394	48	.	.	.
cord-022313-2675sjlf	395	1	Another	another	DT
cord-022313-2675sjlf	395	2	glucosidase	glucosidase	NN
cord-022313-2675sjlf	396	1	I	-PRON-	PRP
cord-022313-2675sjlf	396	2	inhibitor	inhibitor	VBP
cord-022313-2675sjlf	396	3	that	that	WDT
cord-022313-2675sjlf	396	4	also	also	RB
cord-022313-2675sjlf	396	5	is	be	VBZ
cord-022313-2675sjlf	396	6	found	find	VBN
cord-022313-2675sjlf	396	7	in	in	IN
cord-022313-2675sjlf	396	8	plants	plant	NNS
cord-022313-2675sjlf	396	9	is	be	VBZ
cord-022313-2675sjlf	396	10	the	the	DT
cord-022313-2675sjlf	396	11	pyrrolidine	pyrrolidine	JJ
cord-022313-2675sjlf	396	12	alkaloid	alkaloid	NN
cord-022313-2675sjlf	396	13	2,5-dihydroxymethy	2,5-dihydroxymethy	CD
cord-022313-2675sjlf	396	14	1	1	CD
cord-022313-2675sjlf	396	15	-	-	HYPH
cord-022313-2675sjlf	396	16	3,4-dihydroxypyrrolidine	3,4-dihydroxypyrrolidine	CD
cord-022313-2675sjlf	396	17	(	(	-LRB-
cord-022313-2675sjlf	396	18	174	174	CD
cord-022313-2675sjlf	396	19	)	)	-RRB-
cord-022313-2675sjlf	396	20	.	.	.
cord-022313-2675sjlf	397	1	This	this	DT
cord-022313-2675sjlf	397	2	compound	compound	NN
cord-022313-2675sjlf	397	3	,	,	,
cord-022313-2675sjlf	397	4	although	although	IN
cord-022313-2675sjlf	397	5	considerably	considerably	RB
cord-022313-2675sjlf	397	6	less	less	RBR
cord-022313-2675sjlf	397	7	effective	effective	JJ
cord-022313-2675sjlf	397	8	than	than	IN
cord-022313-2675sjlf	397	9	the	the	DT
cord-022313-2675sjlf	397	10	six	six	CD
cord-022313-2675sjlf	397	11	-	-	HYPH
cord-022313-2675sjlf	397	12	membered	membered	JJ
cord-022313-2675sjlf	397	13	ring	ring	NN
cord-022313-2675sjlf	397	14	structures	structure	NNS
cord-022313-2675sjlf	397	15	described	describe	VBN
cord-022313-2675sjlf	397	16	above	above	IN
cord-022313-2675sjlf	397	17	(	(	-LRB-
cord-022313-2675sjlf	397	18	e.g.	e.g.	RB
cord-022313-2675sjlf	397	19	,	,	,
cord-022313-2675sjlf	397	20	compare	compare	VB
cord-022313-2675sjlf	397	21	the	the	DT
cord-022313-2675sjlf	397	22	structure	structure	NN
cord-022313-2675sjlf	397	23	in	in	IN
cord-022313-2675sjlf	397	24	Fig	Fig	NNP
cord-022313-2675sjlf	397	25	.	.	.
cord-022313-2675sjlf	397	26	9	9	CD
cord-022313-2675sjlf	397	27	with	with	IN
cord-022313-2675sjlf	397	28	those	those	DT
cord-022313-2675sjlf	397	29	of	of	IN
cord-022313-2675sjlf	397	30	castanospermine	castanospermine	NN
cord-022313-2675sjlf	397	31	and	and	CC
cord-022313-2675sjlf	397	32	deoxynojirimycin	deoxynojirimycin	NNP
cord-022313-2675sjlf	397	33	)	)	-RRB-
cord-022313-2675sjlf	397	34	,	,	,
cord-022313-2675sjlf	397	35	causes	cause	VBZ
cord-022313-2675sjlf	397	36	similar	similar	JJ
cord-022313-2675sjlf	397	37	changes	change	NNS
cord-022313-2675sjlf	397	38	in	in	IN
cord-022313-2675sjlf	397	39	the	the	DT
cord-022313-2675sjlf	397	40	structures	structure	NNS
cord-022313-2675sjlf	397	41	of	of	IN
cord-022313-2675sjlf	397	42	the	the	DT
cord-022313-2675sjlf	397	43	N	n	NN
cord-022313-2675sjlf	397	44	-	-	HYPH
cord-022313-2675sjlf	397	45	linked	link	VBN
cord-022313-2675sjlf	397	46	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	397	47	.	.	.
cord-022313-2675sjlf	398	1	The	the	DT
cord-022313-2675sjlf	398	2	effect	effect	NN
cord-022313-2675sjlf	398	3	on	on	IN
cord-022313-2675sjlf	398	4	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	398	5	targeting	targeting	NN
cord-022313-2675sjlf	398	6	and	and	CC
cord-022313-2675sjlf	398	7	function	function	NN
cord-022313-2675sjlf	398	8	of	of	IN
cord-022313-2675sjlf	398	9	preventing	prevent	VBG
cord-022313-2675sjlf	398	10	the	the	DT
cord-022313-2675sjlf	398	11	removal	removal	NN
cord-022313-2675sjlf	398	12	of	of	IN
cord-022313-2675sjlf	398	13	glucoses	glucose	NNS
cord-022313-2675sjlf	398	14	from	from	IN
cord-022313-2675sjlf	398	15	the	the	DT
cord-022313-2675sjlf	398	16	N	n	NN
cord-022313-2675sjlf	398	17	-	-	HYPH
cord-022313-2675sjlf	398	18	linked	link	VBN
cord-022313-2675sjlf	398	19	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	398	20	is	be	VBZ
cord-022313-2675sjlf	398	21	quite	quite	RB
cord-022313-2675sjlf	398	22	dra	dra	XX
cord-022313-2675sjlf	398	23	matic	matic	NNP
cord-022313-2675sjlf	398	24	.	.	.
cord-022313-2675sjlf	399	1	For	for	IN
cord-022313-2675sjlf	399	2	example	example	NN
cord-022313-2675sjlf	399	3	,	,	,
cord-022313-2675sjlf	399	4	when	when	WRB
cord-022313-2675sjlf	399	5	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	399	6	(	(	-LRB-
cord-022313-2675sjlf	399	7	Hep	Hep	NNP
cord-022313-2675sjlf	399	8	-	-	HYPH
cord-022313-2675sjlf	399	9	G2	G2	NNP
cord-022313-2675sjlf	399	10	cells	cell	NNS
cord-022313-2675sjlf	399	11	)	)	-RRB-
cord-022313-2675sjlf	399	12	are	be	VBP
cord-022313-2675sjlf	399	13	incubated	incubate	VBN
cord-022313-2675sjlf	399	14	in	in	IN
cord-022313-2675sjlf	399	15	the	the	DT
cord-022313-2675sjlf	399	16	presence	presence	NN
cord-022313-2675sjlf	399	17	of	of	IN
cord-022313-2675sjlf	399	18	deoxynojirimycin	deoxynojirimycin	NNS
cord-022313-2675sjlf	399	19	,	,	,
cord-022313-2675sjlf	399	20	the	the	DT
cord-022313-2675sjlf	399	21	rate	rate	NN
cord-022313-2675sjlf	399	22	of	of	IN
cord-022313-2675sjlf	399	23	secretion	secretion	NN
cord-022313-2675sjlf	399	24	of	of	IN
cord-022313-2675sjlf	399	25	a	a	DT
cord-022313-2675sjlf	399	26	r	r	NN
cord-022313-2675sjlf	399	27	antitrypsin	antitrypsin	NN
cord-022313-2675sjlf	399	28	was	be	VBD
cord-022313-2675sjlf	399	29	substantially	substantially	RB
cord-022313-2675sjlf	399	30	diminished	diminish	VBN
cord-022313-2675sjlf	399	31	,	,	,
cord-022313-2675sjlf	399	32	whereas	whereas	IN
cord-022313-2675sjlf	399	33	the	the	DT
cord-022313-2675sjlf	399	34	rate	rate	NN
cord-022313-2675sjlf	399	35	of	of	IN
cord-022313-2675sjlf	399	36	secretion	secretion	NN
cord-022313-2675sjlf	399	37	of	of	IN
cord-022313-2675sjlf	399	38	other	other	JJ
cord-022313-2675sjlf	399	39	N	n	CD
cord-022313-2675sjlf	399	40	-	-	HYPH
cord-022313-2675sjlf	399	41	linked	link	VBN
cord-022313-2675sjlf	399	42	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	399	43	such	such	JJ
cord-022313-2675sjlf	399	44	as	as	IN
cord-022313-2675sjlf	399	45	ceruloplasmin	ceruloplasmin	NNP
cord-022313-2675sjlf	399	46	and	and	CC
cord-022313-2675sjlf	399	47	the	the	DT
cord-022313-2675sjlf	399	48	C3	c3	NN
cord-022313-2675sjlf	399	49	component	component	NN
cord-022313-2675sjlf	399	50	of	of	IN
cord-022313-2675sjlf	399	51	complement	complement	NN
cord-022313-2675sjlf	399	52	was	be	VBD
cord-022313-2675sjlf	399	53	only	only	RB
cord-022313-2675sjlf	399	54	marginally	marginally	RB
cord-022313-2675sjlf	399	55	altered	alter	VBN
cord-022313-2675sjlf	399	56	.	.	.
cord-022313-2675sjlf	400	1	Based	base	VBN
cord-022313-2675sjlf	400	2	on	on	IN
cord-022313-2675sjlf	400	3	some	some	DT
cord-022313-2675sjlf	400	4	preliminary	preliminary	JJ
cord-022313-2675sjlf	400	5	cell	cell	NN
cord-022313-2675sjlf	400	6	fractionation	fractionation	NN
cord-022313-2675sjlf	400	7	studies	study	NNS
cord-022313-2675sjlf	400	8	,	,	,
cord-022313-2675sjlf	400	9	it	-PRON-	PRP
cord-022313-2675sjlf	400	10	was	be	VBD
cord-022313-2675sjlf	400	11	suggested	suggest	VBN
cord-022313-2675sjlf	400	12	that	that	IN
cord-022313-2675sjlf	400	13	the	the	DT
cord-022313-2675sjlf	400	14	presence	presence	NN
cord-022313-2675sjlf	400	15	of	of	IN
cord-022313-2675sjlf	400	16	glucose	glucose	NN
cord-022313-2675sjlf	400	17	on	on	IN
cord-022313-2675sjlf	400	18	the	the	DT
cord-022313-2675sjlf	400	19	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	400	20	of	of	IN
cord-022313-2675sjlf	400	21	certain	certain	JJ
cord-022313-2675sjlf	400	22	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	400	23	might	may	MD
cord-022313-2675sjlf	400	24	retard	retard	VB
cord-022313-2675sjlf	400	25	the	the	DT
cord-022313-2675sjlf	400	26	move	move	NN
cord-022313-2675sjlf	400	27	ment	ment	NN
cord-022313-2675sjlf	400	28	of	of	IN
cord-022313-2675sjlf	400	29	these	these	DT
cord-022313-2675sjlf	400	30	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	400	31	from	from	IN
cord-022313-2675sjlf	400	32	the	the	DT
cord-022313-2675sjlf	400	33	ER	ER	NNP
cord-022313-2675sjlf	400	34	to	to	IN
cord-022313-2675sjlf	400	35	the	the	DT
cord-022313-2675sjlf	400	36	Golgi	Golgi	NNP
cord-022313-2675sjlf	400	37	apparatus	apparatus	NN
cord-022313-2675sjlf	400	38	(	(	-LRB-
cord-022313-2675sjlf	400	39	175	175	CD
cord-022313-2675sjlf	400	40	)	)	-RRB-
cord-022313-2675sjlf	400	41	.	.	.
cord-022313-2675sjlf	401	1	Similar	similar	JJ
cord-022313-2675sjlf	401	2	results	result	NNS
cord-022313-2675sjlf	401	3	were	be	VBD
cord-022313-2675sjlf	401	4	obtained	obtain	VBN
cord-022313-2675sjlf	401	5	with	with	IN
cord-022313-2675sjlf	401	6	fibroblasts	fibroblast	NNS
cord-022313-2675sjlf	401	7	and	and	CC
cord-022313-2675sjlf	401	8	smooth	smooth	JJ
cord-022313-2675sjlf	401	9	muscle	muscle	NN
cord-022313-2675sjlf	401	10	cells	cell	NNS
cord-022313-2675sjlf	401	11	when	when	WRB
cord-022313-2675sjlf	401	12	the	the	DT
cord-022313-2675sjlf	401	13	effect	effect	NN
cord-022313-2675sjlf	401	14	of	of	IN
cord-022313-2675sjlf	401	15	castanospermine	castanospermine	NN
cord-022313-2675sjlf	401	16	on	on	IN
cord-022313-2675sjlf	401	17	the	the	DT
cord-022313-2675sjlf	401	18	LDL	LDL	NNP
cord-022313-2675sjlf	401	19	receptor	receptor	NN
cord-022313-2675sjlf	401	20	was	be	VBD
cord-022313-2675sjlf	401	21	examined	examine	VBN
cord-022313-2675sjlf	401	22	.	.	.
cord-022313-2675sjlf	402	1	In	in	IN
cord-022313-2675sjlf	402	2	this	this	DT
cord-022313-2675sjlf	402	3	case	case	NN
cord-022313-2675sjlf	402	4	,	,	,
cord-022313-2675sjlf	402	5	there	there	EX
cord-022313-2675sjlf	402	6	was	be	VBD
cord-022313-2675sjlf	402	7	a	a	DT
cord-022313-2675sjlf	402	8	significant	significant	JJ
cord-022313-2675sjlf	402	9	decrease	decrease	NN
cord-022313-2675sjlf	402	10	in	in	IN
cord-022313-2675sjlf	402	11	the	the	DT
cord-022313-2675sjlf	402	12	binding	binding	NN
cord-022313-2675sjlf	402	13	and	and	CC
cord-022313-2675sjlf	402	14	endocytosis	endocytosis	NN
cord-022313-2675sjlf	402	15	of	of	IN
cord-022313-2675sjlf	402	16	LDL	ldl	NN
cord-022313-2675sjlf	402	17	when	when	WRB
cord-022313-2675sjlf	402	18	arterial	arterial	JJ
cord-022313-2675sjlf	402	19	smooth	smooth	JJ
cord-022313-2675sjlf	402	20	muscle	muscle	NN
cord-022313-2675sjlf	402	21	cells	cell	NNS
cord-022313-2675sjlf	402	22	were	be	VBD
cord-022313-2675sjlf	402	23	upregulated	upregulate	VBN
cord-022313-2675sjlf	402	24	to	to	TO
cord-022313-2675sjlf	402	25	produce	produce	VB
cord-022313-2675sjlf	402	26	LDL	ldl	NN
cord-022313-2675sjlf	402	27	receptors	receptor	NNS
cord-022313-2675sjlf	402	28	in	in	IN
cord-022313-2675sjlf	402	29	the	the	DT
cord-022313-2675sjlf	402	30	presence	presence	NN
cord-022313-2675sjlf	402	31	of	of	IN
cord-022313-2675sjlf	402	32	castanospermine	castanospermine	NN
cord-022313-2675sjlf	402	33	.	.	.
cord-022313-2675sjlf	403	1	The	the	DT
cord-022313-2675sjlf	403	2	reason	reason	NN
cord-022313-2675sjlf	403	3	for	for	IN
cord-022313-2675sjlf	403	4	this	this	DT
cord-022313-2675sjlf	403	5	decreased	decrease	VBN
cord-022313-2675sjlf	403	6	binding	binding	NN
cord-022313-2675sjlf	403	7	was	be	VBD
cord-022313-2675sjlf	403	8	shown	show	VBN
cord-022313-2675sjlf	403	9	to	to	TO
cord-022313-2675sjlf	403	10	be	be	VB
cord-022313-2675sjlf	403	11	due	due	JJ
cord-022313-2675sjlf	403	12	to	to	IN
cord-022313-2675sjlf	403	13	a	a	DT
cord-022313-2675sjlf	403	14	reduced	reduce	VBN
cord-022313-2675sjlf	403	15	number	number	NN
cord-022313-2675sjlf	403	16	of	of	IN
cord-022313-2675sjlf	403	17	receptors	receptor	NNS
cord-022313-2675sjlf	403	18	at	at	IN
cord-022313-2675sjlf	403	19	the	the	DT
cord-022313-2675sjlf	403	20	cell	cell	NN
cord-022313-2675sjlf	403	21	surface	surface	NN
cord-022313-2675sjlf	403	22	rather	rather	RB
cord-022313-2675sjlf	403	23	than	than	IN
cord-022313-2675sjlf	403	24	to	to	IN
cord-022313-2675sjlf	403	25	a	a	DT
cord-022313-2675sjlf	403	26	change	change	NN
cord-022313-2675sjlf	403	27	in	in	IN
cord-022313-2675sjlf	403	28	the	the	DT
cord-022313-2675sjlf	403	29	affinity	affinity	NN
cord-022313-2675sjlf	403	30	of	of	IN
cord-022313-2675sjlf	403	31	receptor	receptor	NN
cord-022313-2675sjlf	403	32	for	for	IN
cord-022313-2675sjlf	403	33	its	-PRON-	PRP$
cord-022313-2675sjlf	403	34	ligand	ligand	NN
cord-022313-2675sjlf	403	35	.	.	.
cord-022313-2675sjlf	404	1	Furthermore	furthermore	RB
cord-022313-2675sjlf	404	2	,	,	,
cord-022313-2675sjlf	404	3	the	the	DT
cord-022313-2675sjlf	404	4	total	total	JJ
cord-022313-2675sjlf	404	5	number	number	NN
cord-022313-2675sjlf	404	6	of	of	IN
cord-022313-2675sjlf	404	7	LDL	LDL	NNP
cord-022313-2675sjlf	404	8	recep	recep	NNP
cord-022313-2675sjlf	404	9	tors	tor	NNS
cord-022313-2675sjlf	404	10	in	in	IN
cord-022313-2675sjlf	404	11	the	the	DT
cord-022313-2675sjlf	404	12	cell	cell	NN
cord-022313-2675sjlf	404	13	did	do	VBD
cord-022313-2675sjlf	404	14	not	not	RB
cord-022313-2675sjlf	404	15	change	change	VB
cord-022313-2675sjlf	404	16	in	in	IN
cord-022313-2675sjlf	404	17	the	the	DT
cord-022313-2675sjlf	404	18	presence	presence	NN
cord-022313-2675sjlf	404	19	of	of	IN
cord-022313-2675sjlf	404	20	castanospermine	castanospermine	NNP
cord-022313-2675sjlf	404	21	,	,	,
cord-022313-2675sjlf	404	22	indicating	indicate	VBG
cord-022313-2675sjlf	404	23	that	that	IN
cord-022313-2675sjlf	404	24	this	this	DT
cord-022313-2675sjlf	404	25	drug	drug	NN
cord-022313-2675sjlf	404	26	did	do	VBD
cord-022313-2675sjlf	404	27	not	not	RB
cord-022313-2675sjlf	404	28	inhibit	inhibit	VB
cord-022313-2675sjlf	404	29	the	the	DT
cord-022313-2675sjlf	404	30	synthesis	synthesis	NN
cord-022313-2675sjlf	404	31	of	of	IN
cord-022313-2675sjlf	404	32	the	the	DT
cord-022313-2675sjlf	404	33	receptor	receptor	NN
cord-022313-2675sjlf	404	34	,	,	,
cord-022313-2675sjlf	404	35	nor	nor	CC
cord-022313-2675sjlf	404	36	did	do	VBD
cord-022313-2675sjlf	404	37	it	-PRON-	PRP
cord-022313-2675sjlf	404	38	affect	affect	VB
cord-022313-2675sjlf	404	39	its	-PRON-	PRP$
cord-022313-2675sjlf	404	40	degradation	degradation	NN
cord-022313-2675sjlf	404	41	.	.	.
cord-022313-2675sjlf	405	1	Cell	cell	NN
cord-022313-2675sjlf	405	2	fractionation	fractionation	NN
cord-022313-2675sjlf	405	3	studies	study	NNS
cord-022313-2675sjlf	405	4	designed	design	VBN
cord-022313-2675sjlf	405	5	to	to	TO
cord-022313-2675sjlf	405	6	isolate	isolate	VB
cord-022313-2675sjlf	405	7	various	various	JJ
cord-022313-2675sjlf	405	8	membrane	membrane	NN
cord-022313-2675sjlf	405	9	fractions	fraction	NNS
cord-022313-2675sjlf	405	10	demonstrated	demonstrate	VBD
cord-022313-2675sjlf	405	11	a	a	DT
cord-022313-2675sjlf	405	12	shift	shift	NN
cord-022313-2675sjlf	405	13	in	in	IN
cord-022313-2675sjlf	405	14	the	the	DT
cord-022313-2675sjlf	405	15	distri	distri	JJ
cord-022313-2675sjlf	405	16	bution	bution	NN
cord-022313-2675sjlf	405	17	of	of	IN
cord-022313-2675sjlf	405	18	LDL	LDL	NNP
cord-022313-2675sjlf	405	19	receptors	receptor	NNS
cord-022313-2675sjlf	405	20	within	within	IN
cord-022313-2675sjlf	405	21	the	the	DT
cord-022313-2675sjlf	405	22	cell	cell	NN
cord-022313-2675sjlf	405	23	compartments	compartment	NNS
cord-022313-2675sjlf	405	24	and	and	CC
cord-022313-2675sjlf	405	25	indicated	indicate	VBD
cord-022313-2675sjlf	405	26	a	a	DT
cord-022313-2675sjlf	405	27	decrease	decrease	NN
cord-022313-2675sjlf	405	28	in	in	IN
cord-022313-2675sjlf	405	29	receptors	receptor	NNS
cord-022313-2675sjlf	405	30	at	at	IN
cord-022313-2675sjlf	405	31	the	the	DT
cord-022313-2675sjlf	405	32	cell	cell	NN
cord-022313-2675sjlf	405	33	surface	surface	NN
cord-022313-2675sjlf	405	34	and	and	CC
cord-022313-2675sjlf	405	35	a	a	DT
cord-022313-2675sjlf	405	36	corresponding	corresponding	JJ
cord-022313-2675sjlf	405	37	increase	increase	NN
cord-022313-2675sjlf	405	38	in	in	IN
cord-022313-2675sjlf	405	39	receptors	receptor	NNS
cord-022313-2675sjlf	405	40	in	in	IN
cord-022313-2675sjlf	405	41	the	the	DT
cord-022313-2675sjlf	405	42	ER	ER	NNP
cord-022313-2675sjlf	405	43	-	-	HYPH
cord-022313-2675sjlf	405	44	Golgi	Golgi	NNP
cord-022313-2675sjlf	405	45	membrane	membrane	NN
cord-022313-2675sjlf	405	46	fractions	fraction	NNS
cord-022313-2675sjlf	405	47	(	(	-LRB-
cord-022313-2675sjlf	405	48	176	176	CD
cord-022313-2675sjlf	405	49	)	)	-RRB-
cord-022313-2675sjlf	405	50	.	.	.
cord-022313-2675sjlf	406	1	In	in	IN
cord-022313-2675sjlf	406	2	the	the	DT
cord-022313-2675sjlf	406	3	case	case	NN
cord-022313-2675sjlf	406	4	of	of	IN
cord-022313-2675sjlf	406	5	IM-9	IM-9	NNP
cord-022313-2675sjlf	406	6	lymphocytes	lymphocyte	NNS
cord-022313-2675sjlf	406	7	,	,	,
cord-022313-2675sjlf	406	8	castanospermine	castanospermine	NNP
cord-022313-2675sjlf	406	9	was	be	VBD
cord-022313-2675sjlf	406	10	used	use	VBN
cord-022313-2675sjlf	406	11	to	to	TO
cord-022313-2675sjlf	406	12	study	study	VB
cord-022313-2675sjlf	406	13	the	the	DT
cord-022313-2675sjlf	406	14	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	406	15	and	and	CC
cord-022313-2675sjlf	406	16	processing	processing	NN
cord-022313-2675sjlf	406	17	of	of	IN
cord-022313-2675sjlf	406	18	the	the	DT
cord-022313-2675sjlf	406	19	insulin	insulin	NN
cord-022313-2675sjlf	406	20	receptor	receptor	NN
cord-022313-2675sjlf	406	21	.	.	.
cord-022313-2675sjlf	407	1	When	when	WRB
cord-022313-2675sjlf	407	2	these	these	DT
cord-022313-2675sjlf	407	3	cells	cell	NNS
cord-022313-2675sjlf	407	4	were	be	VBD
cord-022313-2675sjlf	407	5	treated	treat	VBN
cord-022313-2675sjlf	407	6	with	with	IN
cord-022313-2675sjlf	407	7	this	this	DT
cord-022313-2675sjlf	407	8	alkaloid	alkaloid	NN
cord-022313-2675sjlf	407	9	,	,	,
cord-022313-2675sjlf	407	10	they	-PRON-	PRP
cord-022313-2675sjlf	407	11	showed	show	VBD
cord-022313-2675sjlf	407	12	a	a	DT
cord-022313-2675sjlf	407	13	50	50	CD
cord-022313-2675sjlf	407	14	%	%	NN
cord-022313-2675sjlf	407	15	decrease	decrease	NN
cord-022313-2675sjlf	407	16	in	in	IN
cord-022313-2675sjlf	407	17	cell	cell	NN
cord-022313-2675sjlf	407	18	-	-	HYPH
cord-022313-2675sjlf	407	19	surface	surface	NN
cord-022313-2675sjlf	407	20	insulin	insulin	NN
cord-022313-2675sjlf	407	21	receptors	receptor	NNS
cord-022313-2675sjlf	407	22	as	as	IN
cord-022313-2675sjlf	407	23	demonstrated	demonstrate	VBN
cord-022313-2675sjlf	407	24	by	by	IN
cord-022313-2675sjlf	407	25	the	the	DT
cord-022313-2675sjlf	407	26	binding	binding	NN
cord-022313-2675sjlf	407	27	of	of	IN
cord-022313-2675sjlf	407	28	125	125	CD
cord-022313-2675sjlf	407	29	Iinsulin	Iinsulin	NNP
cord-022313-2675sjlf	407	30	,	,	,
cord-022313-2675sjlf	407	31	as	as	RB
cord-022313-2675sjlf	407	32	well	well	RB
cord-022313-2675sjlf	407	33	as	as	IN
cord-022313-2675sjlf	407	34	by	by	IN
cord-022313-2675sjlf	407	35	Na	Na	NNP
cord-022313-2675sjlf	407	36	125	125	CD
cord-022313-2675sjlf	408	1	I	-PRON-	PRP
cord-022313-2675sjlf	408	2	-	-	HYPH
cord-022313-2675sjlf	408	3	lactoperoxidase	lactoperoxidase	NNP
cord-022313-2675sjlf	408	4	labeling	labeling	NN
cord-022313-2675sjlf	408	5	and	and	CC
cord-022313-2675sjlf	408	6	by	by	IN
cord-022313-2675sjlf	408	7	crosslinking	crosslinke	VBG
cord-022313-2675sjlf	408	8	studies	study	NNS
cord-022313-2675sjlf	408	9	with	with	IN
cord-022313-2675sjlf	408	10	125	125	CD
cord-022313-2675sjlf	408	11	I	i	NN
cord-022313-2675sjlf	408	12	-	-	HYPH
cord-022313-2675sjlf	408	13	insulin	insulin	NN
cord-022313-2675sjlf	408	14	.	.	.
cord-022313-2675sjlf	409	1	These	these	DT
cord-022313-2675sjlf	409	2	studies	study	NNS
cord-022313-2675sjlf	409	3	demonstrated	demonstrate	VBD
cord-022313-2675sjlf	409	4	that	that	IN
cord-022313-2675sjlf	409	5	pro	pro	JJ
cord-022313-2675sjlf	409	6	cessing	cessing	NN
cord-022313-2675sjlf	409	7	,	,	,
cord-022313-2675sjlf	409	8	i.e.	i.e.	FW
cord-022313-2675sjlf	409	9	,	,	,
cord-022313-2675sjlf	409	10	removal	removal	NN
cord-022313-2675sjlf	409	11	of	of	IN
cord-022313-2675sjlf	409	12	glucose	glucose	NN
cord-022313-2675sjlf	409	13	from	from	IN
cord-022313-2675sjlf	409	14	the	the	DT
cord-022313-2675sjlf	409	15	N	n	NN
cord-022313-2675sjlf	409	16	-	-	HYPH
cord-022313-2675sjlf	409	17	linked	link	VBN
cord-022313-2675sjlf	409	18	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	409	19	,	,	,
cord-022313-2675sjlf	409	20	was	be	VBD
cord-022313-2675sjlf	409	21	not	not	RB
cord-022313-2675sjlf	409	22	necessary	necessary	JJ
cord-022313-2675sjlf	409	23	for	for	IN
cord-022313-2675sjlf	409	24	the	the	DT
cord-022313-2675sjlf	409	25	cleavage	cleavage	NN
cord-022313-2675sjlf	409	26	of	of	IN
cord-022313-2675sjlf	409	27	the	the	DT
cord-022313-2675sjlf	409	28	insulin	insulin	NN
cord-022313-2675sjlf	409	29	proreceptor	proreceptor	NN
cord-022313-2675sjlf	409	30	,	,	,
cord-022313-2675sjlf	409	31	i.e.	i.e.	FW
cord-022313-2675sjlf	409	32	,	,	,
cord-022313-2675sjlf	409	33	for	for	IN
cord-022313-2675sjlf	409	34	protein	protein	NN
cord-022313-2675sjlf	409	35	maturation	maturation	NN
cord-022313-2675sjlf	409	36	.	.	.
cord-022313-2675sjlf	410	1	However	however	RB
cord-022313-2675sjlf	410	2	,	,	,
cord-022313-2675sjlf	410	3	as	as	IN
cord-022313-2675sjlf	410	4	indicated	indicate	VBN
cord-022313-2675sjlf	410	5	above	above	RB
cord-022313-2675sjlf	410	6	,	,	,
cord-022313-2675sjlf	410	7	the	the	DT
cord-022313-2675sjlf	410	8	presence	presence	NN
cord-022313-2675sjlf	410	9	of	of	IN
cord-022313-2675sjlf	410	10	glu	glu	NNP
cord-022313-2675sjlf	410	11	cose	cose	NNP
cord-022313-2675sjlf	410	12	appears	appear	VBZ
cord-022313-2675sjlf	410	13	to	to	TO
cord-022313-2675sjlf	410	14	slow	slow	VB
cord-022313-2675sjlf	410	15	down	down	RP
cord-022313-2675sjlf	410	16	the	the	DT
cord-022313-2675sjlf	410	17	transport	transport	NN
cord-022313-2675sjlf	410	18	of	of	IN
cord-022313-2675sjlf	410	19	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	410	20	from	from	IN
cord-022313-2675sjlf	410	21	the	the	DT
cord-022313-2675sjlf	410	22	ER	ER	NNP
cord-022313-2675sjlf	410	23	to	to	IN
cord-022313-2675sjlf	410	24	the	the	DT
cord-022313-2675sjlf	410	25	Golgi	Golgi	NNP
cord-022313-2675sjlf	410	26	apparatus	apparatus	NN
cord-022313-2675sjlf	410	27	(	(	-LRB-
cord-022313-2675sjlf	410	28	177	177	CD
cord-022313-2675sjlf	410	29	)	)	-RRB-
cord-022313-2675sjlf	410	30	.	.	.
cord-022313-2675sjlf	411	1	These	these	DT
cord-022313-2675sjlf	411	2	data	datum	NNS
cord-022313-2675sjlf	411	3	suggest	suggest	VBP
cord-022313-2675sjlf	411	4	the	the	DT
cord-022313-2675sjlf	411	5	presence	presence	NN
cord-022313-2675sjlf	411	6	of	of	IN
cord-022313-2675sjlf	411	7	a	a	DT
cord-022313-2675sjlf	411	8	glucose	glucose	NN
cord-022313-2675sjlf	411	9	receptor	receptor	NN
cord-022313-2675sjlf	411	10	in	in	IN
cord-022313-2675sjlf	411	11	the	the	DT
cord-022313-2675sjlf	411	12	ER	er	NN
cord-022313-2675sjlf	411	13	that	that	IN
cord-022313-2675sjlf	411	14	"	"	``
cord-022313-2675sjlf	411	15	holds	hold	VBZ
cord-022313-2675sjlf	411	16	up	up	RP
cord-022313-2675sjlf	411	17	"	"	''
cord-022313-2675sjlf	411	18	or	or	CC
cord-022313-2675sjlf	411	19	binds	bind	VBZ
cord-022313-2675sjlf	411	20	glucose	glucose	NN
cord-022313-2675sjlf	411	21	-	-	HYPH
cord-022313-2675sjlf	411	22	containing	contain	VBG
cord-022313-2675sjlf	411	23	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	411	24	,	,	,
cord-022313-2675sjlf	411	25	or	or	CC
cord-022313-2675sjlf	411	26	the	the	DT
cord-022313-2675sjlf	411	27	data	datum	NNS
cord-022313-2675sjlf	411	28	may	may	MD
cord-022313-2675sjlf	411	29	indicate	indicate	VB
cord-022313-2675sjlf	411	30	that	that	IN
cord-022313-2675sjlf	411	31	some	some	DT
cord-022313-2675sjlf	411	32	proteins	protein	NNS
cord-022313-2675sjlf	411	33	undergo	undergo	VBP
cord-022313-2675sjlf	411	34	a	a	DT
cord-022313-2675sjlf	411	35	conformational	conformational	JJ
cord-022313-2675sjlf	411	36	change	change	NN
cord-022313-2675sjlf	411	37	when	when	WRB
cord-022313-2675sjlf	411	38	glucose	glucose	NN
cord-022313-2675sjlf	411	39	is	be	VBZ
cord-022313-2675sjlf	411	40	removed	remove	VBN
cord-022313-2675sjlf	411	41	,	,	,
cord-022313-2675sjlf	411	42	and	and	CC
cord-022313-2675sjlf	411	43	the	the	DT
cord-022313-2675sjlf	411	44	newly	newly	RB
cord-022313-2675sjlf	411	45	altered	alter	VBN
cord-022313-2675sjlf	411	46	protein	protein	NN
cord-022313-2675sjlf	411	47	is	be	VBZ
cord-022313-2675sjlf	411	48	transferred	transfer	VBN
cord-022313-2675sjlf	411	49	from	from	IN
cord-022313-2675sjlf	411	50	the	the	DT
cord-022313-2675sjlf	411	51	ER	ER	NNP
cord-022313-2675sjlf	411	52	to	to	IN
cord-022313-2675sjlf	411	53	the	the	DT
cord-022313-2675sjlf	411	54	Golgi	Golgi	NNP
cord-022313-2675sjlf	411	55	at	at	IN
cord-022313-2675sjlf	411	56	a	a	DT
cord-022313-2675sjlf	411	57	more	more	RBR
cord-022313-2675sjlf	411	58	rapid	rapid	JJ
cord-022313-2675sjlf	411	59	rate	rate	NN
cord-022313-2675sjlf	411	60	.	.	.
cord-022313-2675sjlf	412	1	In	in	IN
cord-022313-2675sjlf	412	2	the	the	DT
cord-022313-2675sjlf	412	3	case	case	NN
cord-022313-2675sjlf	412	4	of	of	IN
cord-022313-2675sjlf	412	5	synthesis	synthesis	NN
cord-022313-2675sjlf	412	6	of	of	IN
cord-022313-2675sjlf	412	7	the	the	DT
cord-022313-2675sjlf	412	8	E	e	NN
cord-022313-2675sjlf	412	9	2	2	CD
cord-022313-2675sjlf	412	10	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	412	11	of	of	IN
cord-022313-2675sjlf	412	12	coronavirus	coronavirus	NN
cord-022313-2675sjlf	412	13	,	,	,
cord-022313-2675sjlf	412	14	casta	casta	NNP
cord-022313-2675sjlf	412	15	nospermine	nospermine	NNP
cord-022313-2675sjlf	412	16	or	or	CC
cord-022313-2675sjlf	412	17	deoxynojirimycin	deoxynojirimycin	NNP
cord-022313-2675sjlf	412	18	caused	cause	VBD
cord-022313-2675sjlf	412	19	a	a	DT
cord-022313-2675sjlf	412	20	drop	drop	NN
cord-022313-2675sjlf	412	21	in	in	IN
cord-022313-2675sjlf	412	22	virus	virus	NN
cord-022313-2675sjlf	412	23	formation	formation	NN
cord-022313-2675sjlf	412	24	by	by	IN
cord-022313-2675sjlf	412	25	2	2	CD
cord-022313-2675sjlf	412	26	logs	log	NNS
cord-022313-2675sjlf	412	27	and	and	CC
cord-022313-2675sjlf	412	28	also	also	RB
cord-022313-2675sjlf	412	29	caused	cause	VBD
cord-022313-2675sjlf	412	30	a	a	DT
cord-022313-2675sjlf	412	31	dramatic	dramatic	JJ
cord-022313-2675sjlf	412	32	decrease	decrease	NN
cord-022313-2675sjlf	412	33	in	in	IN
cord-022313-2675sjlf	412	34	the	the	DT
cord-022313-2675sjlf	412	35	appearance	appearance	NN
cord-022313-2675sjlf	412	36	of	of	IN
cord-022313-2675sjlf	412	37	E	e	NN
cord-022313-2675sjlf	412	38	2	2	CD
cord-022313-2675sjlf	412	39	at	at	IN
cord-022313-2675sjlf	412	40	the	the	DT
cord-022313-2675sjlf	412	41	cell	cell	NN
cord-022313-2675sjlf	412	42	surface	surface	NN
cord-022313-2675sjlf	412	43	.	.	.
cord-022313-2675sjlf	413	1	Interestingly	interestingly	RB
cord-022313-2675sjlf	413	2	enough	enough	RB
cord-022313-2675sjlf	413	3	,	,	,
cord-022313-2675sjlf	413	4	the	the	DT
cord-022313-2675sjlf	413	5	E	e	NN
cord-022313-2675sjlf	413	6	2	2	CD
cord-022313-2675sjlf	413	7	that	that	WDT
cord-022313-2675sjlf	413	8	was	be	VBD
cord-022313-2675sjlf	413	9	produced	produce	VBN
cord-022313-2675sjlf	413	10	in	in	IN
cord-022313-2675sjlf	413	11	the	the	DT
cord-022313-2675sjlf	413	12	presence	presence	NN
cord-022313-2675sjlf	413	13	of	of	IN
cord-022313-2675sjlf	413	14	these	these	DT
cord-022313-2675sjlf	413	15	drugs	drug	NNS
cord-022313-2675sjlf	413	16	was	be	VBD
cord-022313-2675sjlf	413	17	still	still	RB
cord-022313-2675sjlf	413	18	acylated	acylate	VBN
cord-022313-2675sjlf	413	19	with	with	IN
cord-022313-2675sjlf	413	20	a	a	DT
cord-022313-2675sjlf	413	21	fatty	fatty	JJ
cord-022313-2675sjlf	413	22	acid	acid	NN
cord-022313-2675sjlf	413	23	,	,	,
cord-022313-2675sjlf	413	24	as	as	IN
cord-022313-2675sjlf	413	25	was	be	VBD
cord-022313-2675sjlf	413	26	the	the	DT
cord-022313-2675sjlf	413	27	control	control	NN
cord-022313-2675sjlf	413	28	E	e	NN
cord-022313-2675sjlf	413	29	2	2	CD
cord-022313-2675sjlf	413	30	,	,	,
cord-022313-2675sjlf	413	31	but	but	CC
cord-022313-2675sjlf	413	32	the	the	DT
cord-022313-2675sjlf	413	33	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	413	34	accumulated	accumulate	VBN
cord-022313-2675sjlf	413	35	intracellularly	intracellularly	RB
cord-022313-2675sjlf	413	36	in	in	IN
cord-022313-2675sjlf	413	37	a	a	DT
cord-022313-2675sjlf	413	38	compartment	compartment	NN
cord-022313-2675sjlf	413	39	that	that	WDT
cord-022313-2675sjlf	413	40	was	be	VBD
cord-022313-2675sjlf	413	41	distinct	distinct	JJ
cord-022313-2675sjlf	413	42	from	from	IN
cord-022313-2675sjlf	413	43	the	the	DT
cord-022313-2675sjlf	413	44	Golgi	Golgi	NNP
cord-022313-2675sjlf	413	45	apparatus	apparatus	NN
cord-022313-2675sjlf	413	46	(	(	-LRB-
cord-022313-2675sjlf	413	47	178	178	CD
cord-022313-2675sjlf	413	48	)	)	-RRB-
cord-022313-2675sjlf	413	49	.	.	.
cord-022313-2675sjlf	414	1	Could	Could	MD
cord-022313-2675sjlf	414	2	this	this	DT
cord-022313-2675sjlf	414	3	compartment	compartment	NN
cord-022313-2675sjlf	414	4	be	be	VB
cord-022313-2675sjlf	414	5	the	the	DT
cord-022313-2675sjlf	414	6	ER	er	NN
cord-022313-2675sjlf	414	7	?	?	.
cord-022313-2675sjlf	415	1	In	in	IN
cord-022313-2675sjlf	415	2	another	another	DT
cord-022313-2675sjlf	415	3	case	case	NN
cord-022313-2675sjlf	415	4	,	,	,
cord-022313-2675sjlf	415	5	post	post	JJ
cord-022313-2675sjlf	415	6	-	-	JJ
cord-022313-2675sjlf	415	7	translational	translational	JJ
cord-022313-2675sjlf	415	8	addition	addition	NN
cord-022313-2675sjlf	415	9	of	of	IN
cord-022313-2675sjlf	415	10	palmitic	palmitic	JJ
cord-022313-2675sjlf	415	11	acid	acid	NN
cord-022313-2675sjlf	415	12	was	be	VBD
cord-022313-2675sjlf	415	13	also	also	RB
cord-022313-2675sjlf	415	14	not	not	RB
cord-022313-2675sjlf	415	15	affected	affect	VBN
cord-022313-2675sjlf	415	16	by	by	IN
cord-022313-2675sjlf	415	17	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	416	1	I	-PRON-	PRP
cord-022313-2675sjlf	416	2	inhibitors	inhibitors	VBP
cord-022313-2675sjlf	416	3	.	.	.
cord-022313-2675sjlf	417	1	The	the	DT
cord-022313-2675sjlf	417	2	Na	Na	NNP
cord-022313-2675sjlf	417	3	channel	channel	NN
cord-022313-2675sjlf	417	4	of	of	IN
cord-022313-2675sjlf	417	5	rat	rat	NNP
cord-022313-2675sjlf	417	6	brain	brain	NN
cord-022313-2675sjlf	417	7	neurons	neuron	NNS
cord-022313-2675sjlf	417	8	is	be	VBZ
cord-022313-2675sjlf	417	9	composed	compose	VBN
cord-022313-2675sjlf	417	10	of	of	IN
cord-022313-2675sjlf	417	11	a	a	DT
cord-022313-2675sjlf	417	12	-	-	:
cord-022313-2675sjlf	417	13	and	and	CC
cord-022313-2675sjlf	417	14	β	β	NN
cord-022313-2675sjlf	417	15	-	-	HYPH
cord-022313-2675sjlf	417	16	subunits	subunit	NNS
cord-022313-2675sjlf	417	17	that	that	WDT
cord-022313-2675sjlf	417	18	form	form	VBP
cord-022313-2675sjlf	417	19	a	a	DT
cord-022313-2675sjlf	417	20	complex	complex	NN
cord-022313-2675sjlf	417	21	during	during	IN
cord-022313-2675sjlf	417	22	maturation	maturation	NN
cord-022313-2675sjlf	417	23	.	.	.
cord-022313-2675sjlf	418	1	The	the	DT
cord-022313-2675sjlf	418	2	α	α	NN
cord-022313-2675sjlf	418	3	-	-	HYPH
cord-022313-2675sjlf	418	4	subunit	subunit	NN
cord-022313-2675sjlf	418	5	is	be	VBZ
cord-022313-2675sjlf	418	6	post	post	VB
cord-022313-2675sjlf	418	7	-	-	JJ
cord-022313-2675sjlf	418	8	translationally	translationally	RB
cord-022313-2675sjlf	418	9	modified	modify	VBN
cord-022313-2675sjlf	418	10	by	by	IN
cord-022313-2675sjlf	418	11	the	the	DT
cord-022313-2675sjlf	418	12	addi	addi	NNP
cord-022313-2675sjlf	418	13	tion	tion	NN
cord-022313-2675sjlf	418	14	of	of	IN
cord-022313-2675sjlf	418	15	a	a	DT
cord-022313-2675sjlf	418	16	palmitic	palmitic	JJ
cord-022313-2675sjlf	418	17	acid	acid	NN
cord-022313-2675sjlf	418	18	,	,	,
cord-022313-2675sjlf	418	19	and	and	CC
cord-022313-2675sjlf	418	20	the	the	DT
cord-022313-2675sjlf	418	21	incorporation	incorporation	NN
cord-022313-2675sjlf	418	22	of	of	IN
cord-022313-2675sjlf	418	23	labeled	label	VBN
cord-022313-2675sjlf	418	24	palmitate	palmitate	NN
cord-022313-2675sjlf	418	25	into	into	IN
cord-022313-2675sjlf	418	26	this	this	DT
cord-022313-2675sjlf	418	27	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	418	28	is	be	VBZ
cord-022313-2675sjlf	418	29	blocked	block	VBN
cord-022313-2675sjlf	418	30	by	by	IN
cord-022313-2675sjlf	418	31	the	the	DT
cord-022313-2675sjlf	418	32	glycosylation	glycosylation	NN
cord-022313-2675sjlf	418	33	inhibitor	inhibitor	NN
cord-022313-2675sjlf	418	34	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	418	35	.	.	.
cord-022313-2675sjlf	419	1	However	however	RB
cord-022313-2675sjlf	419	2	,	,	,
cord-022313-2675sjlf	419	3	the	the	DT
cord-022313-2675sjlf	419	4	α	α	NN
cord-022313-2675sjlf	419	5	-	-	HYPH
cord-022313-2675sjlf	419	6	subunit	subunit	NN
cord-022313-2675sjlf	419	7	formed	form	VBN
cord-022313-2675sjlf	419	8	in	in	IN
cord-022313-2675sjlf	419	9	the	the	DT
cord-022313-2675sjlf	419	10	presence	presence	NN
cord-022313-2675sjlf	419	11	of	of	IN
cord-022313-2675sjlf	419	12	castanospermine	castanospermine	NN
cord-022313-2675sjlf	419	13	is	be	VBZ
cord-022313-2675sjlf	419	14	of	of	IN
cord-022313-2675sjlf	419	15	lower	low	JJR
cord-022313-2675sjlf	419	16	molecular	molecular	JJ
cord-022313-2675sjlf	419	17	weight	weight	NN
cord-022313-2675sjlf	419	18	,	,	,
cord-022313-2675sjlf	419	19	does	do	VBZ
cord-022313-2675sjlf	419	20	not	not	RB
cord-022313-2675sjlf	419	21	contain	contain	VB
cord-022313-2675sjlf	419	22	sialic	sialic	JJ
cord-022313-2675sjlf	419	23	acid	acid	NN
cord-022313-2675sjlf	419	24	,	,	,
cord-022313-2675sjlf	419	25	and	and	CC
cord-022313-2675sjlf	419	26	has	have	VBZ
cord-022313-2675sjlf	419	27	a	a	DT
cord-022313-2675sjlf	419	28	lower	low	JJR
cord-022313-2675sjlf	419	29	sulfate	sulfate	NN
cord-022313-2675sjlf	419	30	content	content	NN
cord-022313-2675sjlf	419	31	,	,	,
cord-022313-2675sjlf	419	32	but	but	CC
cord-022313-2675sjlf	419	33	it	-PRON-	PRP
cord-022313-2675sjlf	419	34	is	be	VBZ
cord-022313-2675sjlf	419	35	similar	similar	JJ
cord-022313-2675sjlf	419	36	to	to	TO
cord-022313-2675sjlf	419	37	control	control	VB
cord-022313-2675sjlf	419	38	α	α	NN
cord-022313-2675sjlf	419	39	-	-	HYPH
cord-022313-2675sjlf	419	40	subunit	subunit	NN
cord-022313-2675sjlf	419	41	in	in	IN
cord-022313-2675sjlf	419	42	its	-PRON-	PRP$
cord-022313-2675sjlf	419	43	content	content	NN
cord-022313-2675sjlf	419	44	of	of	IN
cord-022313-2675sjlf	419	45	palmitic	palmitic	JJ
cord-022313-2675sjlf	419	46	acid	acid	NN
cord-022313-2675sjlf	419	47	(	(	-LRB-
cord-022313-2675sjlf	419	48	179	179	CD
cord-022313-2675sjlf	419	49	)	)	-RRB-
cord-022313-2675sjlf	419	50	.	.	.
cord-022313-2675sjlf	420	1	The	the	DT
cord-022313-2675sjlf	420	2	drug	drug	NN
cord-022313-2675sjlf	420	3	also	also	RB
cord-022313-2675sjlf	420	4	did	do	VBD
cord-022313-2675sjlf	420	5	not	not	RB
cord-022313-2675sjlf	420	6	prevent	prevent	VB
cord-022313-2675sjlf	420	7	the	the	DT
cord-022313-2675sjlf	420	8	covalent	covalent	NNP
cord-022313-2675sjlf	420	9	assembly	assembly	NN
cord-022313-2675sjlf	420	10	of	of	IN
cord-022313-2675sjlf	420	11	a	a	DT
cord-022313-2675sjlf	420	12	-	-	:
cord-022313-2675sjlf	420	13	and	and	CC
cord-022313-2675sjlf	420	14	/3-subunits	/3-subunit	NNS
cord-022313-2675sjlf	420	15	,	,	,
cord-022313-2675sjlf	420	16	nor	nor	CC
cord-022313-2675sjlf	420	17	did	do	VBD
cord-022313-2675sjlf	420	18	it	-PRON-	PRP
cord-022313-2675sjlf	420	19	affect	affect	VB
cord-022313-2675sjlf	420	20	the	the	DT
cord-022313-2675sjlf	420	21	biological	biological	JJ
cord-022313-2675sjlf	420	22	activity	activity	NN
cord-022313-2675sjlf	420	23	of	of	IN
cord-022313-2675sjlf	420	24	the	the	DT
cord-022313-2675sjlf	420	25	channel	channel	NN
cord-022313-2675sjlf	420	26	with	with	IN
cord-022313-2675sjlf	420	27	regard	regard	NN
cord-022313-2675sjlf	420	28	to	to	IN
cord-022313-2675sjlf	420	29	its	-PRON-	PRP$
cord-022313-2675sjlf	420	30	binding	binding	NN
cord-022313-2675sjlf	420	31	of	of	IN
cord-022313-2675sjlf	420	32	saxitoxin	saxitoxin	NN
cord-022313-2675sjlf	420	33	.	.	.
cord-022313-2675sjlf	421	1	The	the	DT
cord-022313-2675sjlf	421	2	external	external	JJ
cord-022313-2675sjlf	421	3	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	421	4	of	of	IN
cord-022313-2675sjlf	421	5	the	the	DT
cord-022313-2675sjlf	421	6	AIDS	AIDS	NNP
cord-022313-2675sjlf	421	7	-	-	HYPH
cord-022313-2675sjlf	421	8	associated	associate	VBN
cord-022313-2675sjlf	421	9	virus	virus	NN
cord-022313-2675sjlf	421	10	HIV	HIV	NNP
cord-022313-2675sjlf	421	11	is	be	VBZ
cord-022313-2675sjlf	421	12	called	call	VBN
cord-022313-2675sjlf	421	13	GP120	GP120	NNP
cord-022313-2675sjlf	421	14	and	and	CC
cord-022313-2675sjlf	421	15	is	be	VBZ
cord-022313-2675sjlf	421	16	a	a	DT
cord-022313-2675sjlf	421	17	heavily	heavily	RB
cord-022313-2675sjlf	421	18	glycosylated	glycosylated	JJ
cord-022313-2675sjlf	421	19	protein	protein	NN
cord-022313-2675sjlf	421	20	that	that	WDT
cord-022313-2675sjlf	421	21	is	be	VBZ
cord-022313-2675sjlf	421	22	involved	involve	VBN
cord-022313-2675sjlf	421	23	in	in	IN
cord-022313-2675sjlf	421	24	the	the	DT
cord-022313-2675sjlf	421	25	mechanism	mechanism	NN
cord-022313-2675sjlf	421	26	of	of	IN
cord-022313-2675sjlf	421	27	attachment	attachment	NN
cord-022313-2675sjlf	421	28	of	of	IN
cord-022313-2675sjlf	421	29	HIV	HIV	NNP
cord-022313-2675sjlf	421	30	to	to	IN
cord-022313-2675sjlf	421	31	the	the	DT
cord-022313-2675sjlf	421	32	CD4	CD4	NNP
cord-022313-2675sjlf	421	33	receptor	receptor	NN
cord-022313-2675sjlf	421	34	on	on	IN
cord-022313-2675sjlf	421	35	Τ	τ	NN
cord-022313-2675sjlf	421	36	lymphocytes	lymphocyte	NNS
cord-022313-2675sjlf	421	37	and	and	CC
cord-022313-2675sjlf	421	38	other	other	JJ
cord-022313-2675sjlf	421	39	susceptible	susceptible	JJ
cord-022313-2675sjlf	421	40	cells	cell	NNS
cord-022313-2675sjlf	421	41	.	.	.
cord-022313-2675sjlf	422	1	The	the	DT
cord-022313-2675sjlf	422	2	GP120	gp120	NN
cord-022313-2675sjlf	422	3	interacts	interact	VBZ
cord-022313-2675sjlf	422	4	with	with	IN
cord-022313-2675sjlf	422	5	target	target	NN
cord-022313-2675sjlf	422	6	molecules	molecule	NNS
cord-022313-2675sjlf	422	7	on	on	IN
cord-022313-2675sjlf	422	8	susceptible	susceptible	JJ
cord-022313-2675sjlf	422	9	cells	cell	NNS
cord-022313-2675sjlf	422	10	to	to	TO
cord-022313-2675sjlf	422	11	cause	cause	VB
cord-022313-2675sjlf	422	12	the	the	DT
cord-022313-2675sjlf	422	13	fusion	fusion	NN
cord-022313-2675sjlf	422	14	of	of	IN
cord-022313-2675sjlf	422	15	the	the	DT
cord-022313-2675sjlf	422	16	cells	cell	NNS
cord-022313-2675sjlf	422	17	,	,	,
cord-022313-2675sjlf	422	18	which	which	WDT
cord-022313-2675sjlf	422	19	is	be	VBZ
cord-022313-2675sjlf	422	20	referred	refer	VBN
cord-022313-2675sjlf	422	21	to	to	IN
cord-022313-2675sjlf	422	22	as	as	IN
cord-022313-2675sjlf	422	23	the	the	DT
cord-022313-2675sjlf	422	24	formation	formation	NN
cord-022313-2675sjlf	422	25	of	of	IN
cord-022313-2675sjlf	422	26	syncytia	syncytia	NN
cord-022313-2675sjlf	422	27	.	.	.
cord-022313-2675sjlf	423	1	Both	both	DT
cord-022313-2675sjlf	423	2	glucosidase	glucosidase	NN
cord-022313-2675sjlf	424	1	I	-PRON-	PRP
cord-022313-2675sjlf	424	2	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	424	3	(	(	-LRB-
cord-022313-2675sjlf	424	4	i.e.	i.e.	FW
cord-022313-2675sjlf	424	5	,	,	,
cord-022313-2675sjlf	424	6	castanospsermine	castanospsermine	NN
cord-022313-2675sjlf	424	7	and	and	CC
cord-022313-2675sjlf	424	8	deoxynojirimycin	deoxynojirimycin	NNS
cord-022313-2675sjlf	424	9	)	)	-RRB-
cord-022313-2675sjlf	424	10	caused	cause	VBD
cord-022313-2675sjlf	424	11	a	a	DT
cord-022313-2675sjlf	424	12	drastic	drastic	JJ
cord-022313-2675sjlf	424	13	inhibition	inhibition	NN
cord-022313-2675sjlf	424	14	of	of	IN
cord-022313-2675sjlf	424	15	virus	virus	NN
cord-022313-2675sjlf	424	16	replication	replication	NN
cord-022313-2675sjlf	424	17	as	as	RB
cord-022313-2675sjlf	424	18	well	well	RB
cord-022313-2675sjlf	424	19	as	as	IN
cord-022313-2675sjlf	424	20	of	of	IN
cord-022313-2675sjlf	424	21	syncytium	syncytium	NN
cord-022313-2675sjlf	424	22	formation	formation	NN
cord-022313-2675sjlf	424	23	(	(	-LRB-
cord-022313-2675sjlf	424	24	180	180	CD
cord-022313-2675sjlf	424	25	)	)	-RRB-
cord-022313-2675sjlf	424	26	(	(	-LRB-
cord-022313-2675sjlf	424	27	181	181	CD
cord-022313-2675sjlf	424	28	)	)	-RRB-
cord-022313-2675sjlf	424	29	(	(	-LRB-
cord-022313-2675sjlf	424	30	182	182	CD
cord-022313-2675sjlf	424	31	)	)	-RRB-
cord-022313-2675sjlf	424	32	.	.	.
cord-022313-2675sjlf	425	1	Because	because	IN
cord-022313-2675sjlf	425	2	of	of	IN
cord-022313-2675sjlf	425	3	these	these	DT
cord-022313-2675sjlf	425	4	interesting	interesting	JJ
cord-022313-2675sjlf	425	5	results	result	NNS
cord-022313-2675sjlf	425	6	,	,	,
cord-022313-2675sjlf	425	7	castanospermine	castanospermine	NN
cord-022313-2675sjlf	425	8	and	and	CC
cord-022313-2675sjlf	425	9	deoxynojirimycin	deoxynojirimycin	NNS
cord-022313-2675sjlf	425	10	,	,	,
cord-022313-2675sjlf	425	11	as	as	RB
cord-022313-2675sjlf	425	12	well	well	RB
cord-022313-2675sjlf	425	13	as	as	IN
cord-022313-2675sjlf	425	14	other	other	JJ
cord-022313-2675sjlf	425	15	glucosidase	glucosidase	NN
cord-022313-2675sjlf	426	1	I	-PRON-	PRP
cord-022313-2675sjlf	426	2	and	and	CC
cord-022313-2675sjlf	426	3	II	II	NNP
cord-022313-2675sjlf	426	4	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	426	5	and	and	CC
cord-022313-2675sjlf	426	6	analogs	analog	NNS
cord-022313-2675sjlf	426	7	of	of	IN
cord-022313-2675sjlf	426	8	these	these	DT
cord-022313-2675sjlf	426	9	various	various	JJ
cord-022313-2675sjlf	426	10	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	426	11	,	,	,
cord-022313-2675sjlf	426	12	are	be	VBP
cord-022313-2675sjlf	426	13	being	be	VBG
cord-022313-2675sjlf	426	14	tested	test	VBN
cord-022313-2675sjlf	426	15	as	as	IN
cord-022313-2675sjlf	426	16	potential	potential	JJ
cord-022313-2675sjlf	426	17	anti	anti	JJ
cord-022313-2675sjlf	426	18	-	-	JJ
cord-022313-2675sjlf	426	19	AIDS	aids	JJ
cord-022313-2675sjlf	426	20	compounds	compound	NNS
cord-022313-2675sjlf	426	21	.	.	.
cord-022313-2675sjlf	427	1	As	as	IN
cord-022313-2675sjlf	427	2	shown	show	VBN
cord-022313-2675sjlf	427	3	in	in	IN
cord-022313-2675sjlf	427	4	Fig	Fig	NNP
cord-022313-2675sjlf	427	5	.	.	.
cord-022313-2675sjlf	428	1	9	9	LS
cord-022313-2675sjlf	428	2	,	,	,
cord-022313-2675sjlf	428	3	there	there	EX
cord-022313-2675sjlf	428	4	are	be	VBP
cord-022313-2675sjlf	428	5	other	other	JJ
cord-022313-2675sjlf	428	6	compounds	compound	NNS
cord-022313-2675sjlf	428	7	besides	besides	IN
cord-022313-2675sjlf	428	8	castano	castano	NNP
cord-022313-2675sjlf	428	9	spermine	spermine	NN
cord-022313-2675sjlf	428	10	and	and	CC
cord-022313-2675sjlf	428	11	deoxynojirimycin	deoxynojirimycin	NNP
cord-022313-2675sjlf	428	12	,	,	,
cord-022313-2675sjlf	428	13	that	that	WDT
cord-022313-2675sjlf	428	14	also	also	RB
cord-022313-2675sjlf	428	15	have	have	VBP
cord-022313-2675sjlf	428	16	activity	activity	NN
cord-022313-2675sjlf	428	17	against	against	IN
cord-022313-2675sjlf	428	18	the	the	DT
cord-022313-2675sjlf	428	19	α	α	NN
cord-022313-2675sjlf	428	20	-	-	HYPH
cord-022313-2675sjlf	428	21	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	428	22	and	and	CC
cord-022313-2675sjlf	428	23	that	that	DT
cord-022313-2675sjlf	428	24	function	function	NN
cord-022313-2675sjlf	428	25	as	as	IN
cord-022313-2675sjlf	428	26	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	428	27	processing	processing	NN
cord-022313-2675sjlf	428	28	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	428	29	.	.	.
cord-022313-2675sjlf	429	1	One	one	CD
cord-022313-2675sjlf	429	2	of	of	IN
cord-022313-2675sjlf	429	3	these	these	DT
cord-022313-2675sjlf	429	4	compounds	compound	NNS
cord-022313-2675sjlf	429	5	is	be	VBZ
cord-022313-2675sjlf	429	6	the	the	DT
cord-022313-2675sjlf	429	7	pyrrolidine	pyrrolidine	JJ
cord-022313-2675sjlf	429	8	alkaloid	alkaloid	NN
cord-022313-2675sjlf	429	9	mentioned	mention	VBD
cord-022313-2675sjlf	429	10	earlier	early	RBR
cord-022313-2675sjlf	429	11	and	and	CC
cord-022313-2675sjlf	429	12	referred	refer	VBD
cord-022313-2675sjlf	429	13	to	to	IN
cord-022313-2675sjlf	429	14	as	as	IN
cord-022313-2675sjlf	429	15	2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine	2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine	CD
cord-022313-2675sjlf	429	16	(	(	-LRB-
cord-022313-2675sjlf	429	17	DMDP	DMDP	NNP
cord-022313-2675sjlf	429	18	)	)	-RRB-
cord-022313-2675sjlf	429	19	,	,	,
cord-022313-2675sjlf	429	20	which	which	WDT
cord-022313-2675sjlf	429	21	has	have	VBZ
cord-022313-2675sjlf	429	22	been	be	VBN
cord-022313-2675sjlf	429	23	found	find	VBN
cord-022313-2675sjlf	429	24	in	in	IN
cord-022313-2675sjlf	429	25	several	several	JJ
cord-022313-2675sjlf	429	26	plants	plant	NNS
cord-022313-2675sjlf	429	27	of	of	IN
cord-022313-2675sjlf	429	28	the	the	DT
cord-022313-2675sjlf	429	29	Leguminosae	Leguminosae	NNP
cord-022313-2675sjlf	429	30	family	family	NN
cord-022313-2675sjlf	429	31	.	.	.
cord-022313-2675sjlf	430	1	In	in	IN
cord-022313-2675sjlf	430	2	cell	cell	NN
cord-022313-2675sjlf	430	3	culture	culture	NN
cord-022313-2675sjlf	430	4	,	,	,
cord-022313-2675sjlf	430	5	DMDP	DMDP	NNP
cord-022313-2675sjlf	430	6	gives	give	VBZ
cord-022313-2675sjlf	430	7	the	the	DT
cord-022313-2675sjlf	430	8	same	same	JJ
cord-022313-2675sjlf	430	9	type	type	NN
cord-022313-2675sjlf	430	10	of	of	IN
cord-022313-2675sjlf	430	11	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	430	12	structure	structure	NN
cord-022313-2675sjlf	430	13	,	,	,
cord-022313-2675sjlf	430	14	i.e.	i.e.	FW
cord-022313-2675sjlf	430	15	,	,	,
cord-022313-2675sjlf	430	16	Glc	Glc	NNP
cord-022313-2675sjlf	430	17	3	3	CD
cord-022313-2675sjlf	430	18	Man	Man	NNP
cord-022313-2675sjlf	430	19	7	7	CD
cord-022313-2675sjlf	430	20	_	_	NN
cord-022313-2675sjlf	430	21	9	9	CD
cord-022313-2675sjlf	431	1	(	(	-LRB-
cord-022313-2675sjlf	431	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	431	3	)	)	-RRB-
cord-022313-2675sjlf	431	4	2	2	CD
cord-022313-2675sjlf	431	5	,	,	,
cord-022313-2675sjlf	431	6	as	as	IN
cord-022313-2675sjlf	431	7	does	do	VBZ
cord-022313-2675sjlf	431	8	castanospermine	castanospermine	NN
cord-022313-2675sjlf	431	9	,	,	,
cord-022313-2675sjlf	431	10	although	although	IN
cord-022313-2675sjlf	431	11	it	-PRON-	PRP
cord-022313-2675sjlf	431	12	is	be	VBZ
cord-022313-2675sjlf	431	13	much	much	RB
cord-022313-2675sjlf	431	14	less	less	RBR
cord-022313-2675sjlf	431	15	active	active	JJ
cord-022313-2675sjlf	431	16	as	as	IN
cord-022313-2675sjlf	431	17	an	an	DT
cord-022313-2675sjlf	431	18	inhibitor	inhibitor	NN
cord-022313-2675sjlf	431	19	(	(	-LRB-
cord-022313-2675sjlf	431	20	i.e.	i.e.	FW
cord-022313-2675sjlf	431	21	,	,	,
cord-022313-2675sjlf	431	22	higher	high	JJR
cord-022313-2675sjlf	431	23	concentrations	concentration	NNS
cord-022313-2675sjlf	431	24	are	be	VBP
cord-022313-2675sjlf	431	25	required	require	VBN
cord-022313-2675sjlf	431	26	)	)	-RRB-
cord-022313-2675sjlf	431	27	(	(	-LRB-
cord-022313-2675sjlf	431	28	174	174	CD
cord-022313-2675sjlf	431	29	)	)	-RRB-
cord-022313-2675sjlf	431	30	.	.	.
cord-022313-2675sjlf	432	1	Nevertheless	nevertheless	RB
cord-022313-2675sjlf	432	2	,	,	,
cord-022313-2675sjlf	432	3	it	-PRON-	PRP
cord-022313-2675sjlf	432	4	is	be	VBZ
cord-022313-2675sjlf	432	5	an	an	DT
cord-022313-2675sjlf	432	6	interesting	interesting	JJ
cord-022313-2675sjlf	432	7	inhibitor	inhibitor	NN
cord-022313-2675sjlf	432	8	because	because	IN
cord-022313-2675sjlf	432	9	it	-PRON-	PRP
cord-022313-2675sjlf	432	10	demonstrates	demonstrate	VBZ
cord-022313-2675sjlf	432	11	that	that	IN
cord-022313-2675sjlf	432	12	a	a	DT
cord-022313-2675sjlf	432	13	six	six	CD
cord-022313-2675sjlf	432	14	-	-	HYPH
cord-022313-2675sjlf	432	15	membered	membered	JJ
cord-022313-2675sjlf	432	16	ring	ring	NN
cord-022313-2675sjlf	432	17	structure	structure	NN
cord-022313-2675sjlf	432	18	is	be	VBZ
cord-022313-2675sjlf	432	19	not	not	RB
cord-022313-2675sjlf	432	20	absolutely	absolutely	RB
cord-022313-2675sjlf	432	21	required	require	VBN
cord-022313-2675sjlf	432	22	for	for	IN
cord-022313-2675sjlf	432	23	inhibitory	inhibitory	JJ
cord-022313-2675sjlf	432	24	activity	activity	NN
cord-022313-2675sjlf	432	25	,	,	,
cord-022313-2675sjlf	432	26	and	and	CC
cord-022313-2675sjlf	432	27	knowledge	knowledge	NN
cord-022313-2675sjlf	432	28	of	of	IN
cord-022313-2675sjlf	432	29	such	such	JJ
cord-022313-2675sjlf	432	30	structures	structure	NNS
cord-022313-2675sjlf	432	31	helps	help	VBZ
cord-022313-2675sjlf	432	32	us	-PRON-	PRP
cord-022313-2675sjlf	432	33	to	to	TO
cord-022313-2675sjlf	432	34	define	define	VB
cord-022313-2675sjlf	432	35	the	the	DT
cord-022313-2675sjlf	432	36	particular	particular	JJ
cord-022313-2675sjlf	432	37	structural	structural	JJ
cord-022313-2675sjlf	432	38	requirements	requirement	NNS
cord-022313-2675sjlf	432	39	that	that	WDT
cord-022313-2675sjlf	432	40	are	be	VBP
cord-022313-2675sjlf	432	41	necessary	necessary	JJ
cord-022313-2675sjlf	432	42	for	for	IN
cord-022313-2675sjlf	432	43	such	such	JJ
cord-022313-2675sjlf	432	44	biological	biological	JJ
cord-022313-2675sjlf	432	45	activity	activity	NN
cord-022313-2675sjlf	432	46	.	.	.
cord-022313-2675sjlf	433	1	Along	along	IN
cord-022313-2675sjlf	433	2	these	these	DT
cord-022313-2675sjlf	433	3	lines	line	NNS
cord-022313-2675sjlf	433	4	,	,	,
cord-022313-2675sjlf	433	5	two	two	CD
cord-022313-2675sjlf	433	6	other	other	JJ
cord-022313-2675sjlf	433	7	structures	structure	NNS
cord-022313-2675sjlf	433	8	that	that	WDT
cord-022313-2675sjlf	433	9	are	be	VBP
cord-022313-2675sjlf	433	10	also	also	RB
cord-022313-2675sjlf	433	11	interesting	interesting	JJ
cord-022313-2675sjlf	433	12	glucosidase	glucosidase	NN
cord-022313-2675sjlf	433	13	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	433	14	,	,	,
cord-022313-2675sjlf	433	15	partly	partly	RB
cord-022313-2675sjlf	433	16	because	because	IN
cord-022313-2675sjlf	433	17	they	-PRON-	PRP
cord-022313-2675sjlf	433	18	are	be	VBP
cord-022313-2675sjlf	433	19	unusual	unusual	JJ
cord-022313-2675sjlf	433	20	and	and	CC
cord-022313-2675sjlf	433	21	partly	partly	RB
cord-022313-2675sjlf	433	22	because	because	IN
cord-022313-2675sjlf	433	23	they	-PRON-	PRP
cord-022313-2675sjlf	433	24	show	show	VBP
cord-022313-2675sjlf	433	25	more	more	JJR
cord-022313-2675sjlf	433	26	selectivity	selectivity	NN
cord-022313-2675sjlf	433	27	than	than	IN
cord-022313-2675sjlf	433	28	those	those	DT
cord-022313-2675sjlf	433	29	described	describe	VBN
cord-022313-2675sjlf	433	30	thus	thus	RB
cord-022313-2675sjlf	433	31	far	far	RB
cord-022313-2675sjlf	433	32	,	,	,
cord-022313-2675sjlf	433	33	are	be	VBP
cord-022313-2675sjlf	433	34	shown	show	VBN
cord-022313-2675sjlf	433	35	in	in	IN
cord-022313-2675sjlf	433	36	Fig	Fig	NNP
cord-022313-2675sjlf	433	37	.	.	.
cord-022313-2675sjlf	434	1	9	9	LS
cord-022313-2675sjlf	434	2	.	.	.
cord-022313-2675sjlf	435	1	Australine	Australine	NNP
cord-022313-2675sjlf	435	2	is	be	VBZ
cord-022313-2675sjlf	435	3	a	a	DT
cord-022313-2675sjlf	435	4	tetrahydroxypyrrolizidine	tetrahydroxypyrrolizidine	NN
cord-022313-2675sjlf	435	5	alkaloid	alkaloid	NN
cord-022313-2675sjlf	435	6	that	that	WDT
cord-022313-2675sjlf	435	7	was	be	VBD
cord-022313-2675sjlf	435	8	isolated	isolate	VBN
cord-022313-2675sjlf	435	9	from	from	IN
cord-022313-2675sjlf	435	10	the	the	DT
cord-022313-2675sjlf	435	11	seeds	seed	NNS
cord-022313-2675sjlf	435	12	of	of	IN
cord-022313-2675sjlf	435	13	the	the	DT
cord-022313-2675sjlf	435	14	tree	tree	NN
cord-022313-2675sjlf	435	15	C.	C.	NNP
cord-022313-2675sjlf	435	16	australe	australe	NNP
cord-022313-2675sjlf	435	17	(	(	-LRB-
cord-022313-2675sjlf	435	18	as	as	IN
cord-022313-2675sjlf	435	19	is	be	VBZ
cord-022313-2675sjlf	435	20	castanospermine	castanospermine	NN
cord-022313-2675sjlf	435	21	)	)	-RRB-
cord-022313-2675sjlf	435	22	.	.	.
cord-022313-2675sjlf	436	1	This	this	DT
cord-022313-2675sjlf	436	2	compound	compound	NN
cord-022313-2675sjlf	436	3	has	have	VBZ
cord-022313-2675sjlf	436	4	a	a	DT
cord-022313-2675sjlf	436	5	unique	unique	JJ
cord-022313-2675sjlf	436	6	substitution	substitution	NN
cord-022313-2675sjlf	436	7	pattern	pattern	NN
cord-022313-2675sjlf	436	8	(	(	-LRB-
cord-022313-2675sjlf	436	9	i.e.	i.e.	FW
cord-022313-2675sjlf	436	10	,	,	,
cord-022313-2675sjlf	436	11	(	(	-LRB-
cord-022313-2675sjlf	436	12	lR,2R,3R,7S,7aS)-3-hydroxymethyl	lr,2r,3r,7s,7as)-3-hydroxymethyl	NN
cord-022313-2675sjlf	436	13	-	-	HYPH
cord-022313-2675sjlf	436	14	l,2,7-trihydroxypyrrolizidine	l,2,7-trihydroxypyrrolizidine	NNP
cord-022313-2675sjlf	436	15	)	)	-RRB-
cord-022313-2675sjlf	436	16	.	.	.
cord-022313-2675sjlf	437	1	This	this	DT
cord-022313-2675sjlf	437	2	bicyclic	bicyclic	JJ
cord-022313-2675sjlf	437	3	alkaloid	alkaloid	NN
cord-022313-2675sjlf	437	4	is	be	VBZ
cord-022313-2675sjlf	437	5	a	a	DT
cord-022313-2675sjlf	437	6	reasonably	reasonably	RB
cord-022313-2675sjlf	437	7	good	good	JJ
cord-022313-2675sjlf	437	8	,	,	,
cord-022313-2675sjlf	437	9	competitive	competitive	JJ
cord-022313-2675sjlf	437	10	inhibitor	inhibitor	NN
cord-022313-2675sjlf	437	11	of	of	IN
cord-022313-2675sjlf	437	12	the	the	DT
cord-022313-2675sjlf	437	13	fungal	fungal	JJ
cord-022313-2675sjlf	437	14	amyloglucosidase	amyloglucosidase	NN
cord-022313-2675sjlf	437	15	(	(	-LRB-
cord-022313-2675sjlf	437	16	an	an	DT
cord-022313-2675sjlf	437	17	aryl	aryl	NN
cord-022313-2675sjlf	437	18	-	-	HYPH
cord-022313-2675sjlf	437	19	glucosidase	glucosidase	NN
cord-022313-2675sjlf	437	20	)	)	-RRB-
cord-022313-2675sjlf	438	1	and	and	CC
cord-022313-2675sjlf	438	2	it	-PRON-	PRP
cord-022313-2675sjlf	438	3	also	also	RB
cord-022313-2675sjlf	438	4	inhibits	inhibit	VBZ
cord-022313-2675sjlf	438	5	the	the	DT
cord-022313-2675sjlf	438	6	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	438	7	pro	pro	JJ
cord-022313-2675sjlf	438	8	cessing	cessing	NN
cord-022313-2675sjlf	438	9	enzyme	enzyme	NN
cord-022313-2675sjlf	438	10	glucosidase	glucosidase	NN
cord-022313-2675sjlf	438	11	I.	i.	NN
cord-022313-2675sjlf	439	1	However	however	RB
cord-022313-2675sjlf	439	2	,	,	,
cord-022313-2675sjlf	439	3	in	in	IN
cord-022313-2675sjlf	439	4	contrast	contrast	NN
cord-022313-2675sjlf	439	5	to	to	IN
cord-022313-2675sjlf	439	6	castanospermine	castanospermine	NN
cord-022313-2675sjlf	439	7	and	and	CC
cord-022313-2675sjlf	439	8	deoxynojirimycin	deoxynojirimycin	NNS
cord-022313-2675sjlf	439	9	,	,	,
cord-022313-2675sjlf	439	10	australine	australine	NN
cord-022313-2675sjlf	439	11	is	be	VBZ
cord-022313-2675sjlf	439	12	a	a	DT
cord-022313-2675sjlf	439	13	very	very	RB
cord-022313-2675sjlf	439	14	poor	poor	JJ
cord-022313-2675sjlf	439	15	inhibitor	inhibitor	NN
cord-022313-2675sjlf	439	16	of	of	IN
cord-022313-2675sjlf	439	17	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	439	18	II	II	NNP
cord-022313-2675sjlf	439	19	(	(	-LRB-
cord-022313-2675sjlf	439	20	183	183	CD
cord-022313-2675sjlf	439	21	)	)	-RRB-
cord-022313-2675sjlf	439	22	.	.	.
cord-022313-2675sjlf	440	1	This	this	DT
cord-022313-2675sjlf	440	2	compound	compound	NN
cord-022313-2675sjlf	440	3	is	be	VBZ
cord-022313-2675sjlf	440	4	the	the	DT
cord-022313-2675sjlf	440	5	first	first	JJ
cord-022313-2675sjlf	440	6	glucosidase	glucosidase	NN
cord-022313-2675sjlf	440	7	inhibitor	inhibitor	NN
cord-022313-2675sjlf	440	8	to	to	TO
cord-022313-2675sjlf	440	9	distinguish	distinguish	VB
cord-022313-2675sjlf	440	10	between	between	IN
cord-022313-2675sjlf	440	11	these	these	DT
cord-022313-2675sjlf	440	12	two	two	CD
cord-022313-2675sjlf	440	13	processing	processing	NN
cord-022313-2675sjlf	440	14	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	440	15	.	.	.
cord-022313-2675sjlf	441	1	Thus	thus	RB
cord-022313-2675sjlf	441	2	,	,	,
cord-022313-2675sjlf	441	3	additional	additional	JJ
cord-022313-2675sjlf	441	4	compounds	compound	NNS
cord-022313-2675sjlf	441	5	such	such	JJ
cord-022313-2675sjlf	441	6	as	as	IN
cord-022313-2675sjlf	441	7	australine	australine	NN
cord-022313-2675sjlf	441	8	that	that	WDT
cord-022313-2675sjlf	441	9	show	show	VBP
cord-022313-2675sjlf	441	10	increased	increase	VBD
cord-022313-2675sjlf	441	11	specificity	specificity	NN
cord-022313-2675sjlf	441	12	will	will	MD
cord-022313-2675sjlf	441	13	be	be	VB
cord-022313-2675sjlf	441	14	valuable	valuable	JJ
cord-022313-2675sjlf	441	15	to	to	TO
cord-022313-2675sjlf	441	16	help	help	VB
cord-022313-2675sjlf	441	17	us	-PRON-	PRP
cord-022313-2675sjlf	441	18	understand	understand	VB
cord-022313-2675sjlf	441	19	how	how	WRB
cord-022313-2675sjlf	441	20	these	these	DT
cord-022313-2675sjlf	441	21	two	two	CD
cord-022313-2675sjlf	441	22	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	441	23	differ	differ	VBP
cord-022313-2675sjlf	441	24	in	in	IN
cord-022313-2675sjlf	441	25	their	-PRON-	PRP$
cord-022313-2675sjlf	441	26	mecha	mecha	NN
cord-022313-2675sjlf	441	27	nism	nism	NN
cord-022313-2675sjlf	441	28	of	of	IN
cord-022313-2675sjlf	441	29	catalysis	catalysis	NN
cord-022313-2675sjlf	441	30	and	and	CC
cord-022313-2675sjlf	441	31	also	also	RB
cord-022313-2675sjlf	441	32	to	to	TO
cord-022313-2675sjlf	441	33	determine	determine	VB
cord-022313-2675sjlf	441	34	the	the	DT
cord-022313-2675sjlf	441	35	chirality	chirality	NN
cord-022313-2675sjlf	441	36	and	and	CC
cord-022313-2675sjlf	441	37	spacial	spacial	JJ
cord-022313-2675sjlf	441	38	config	config	NN
cord-022313-2675sjlf	441	39	urations	uration	NNS
cord-022313-2675sjlf	441	40	that	that	WDT
cord-022313-2675sjlf	441	41	are	be	VBP
cord-022313-2675sjlf	441	42	necessary	necessary	JJ
cord-022313-2675sjlf	441	43	for	for	IN
cord-022313-2675sjlf	441	44	activity	activity	NN
cord-022313-2675sjlf	441	45	of	of	IN
cord-022313-2675sjlf	441	46	various	various	JJ
cord-022313-2675sjlf	441	47	glycosidases	glycosidase	NNS
cord-022313-2675sjlf	441	48	.	.	.
cord-022313-2675sjlf	442	1	Another	another	DT
cord-022313-2675sjlf	442	2	inhibitor	inhibitor	NN
cord-022313-2675sjlf	442	3	whose	whose	WP$
cord-022313-2675sjlf	442	4	structure	structure	NN
cord-022313-2675sjlf	442	5	is	be	VBZ
cord-022313-2675sjlf	442	6	shown	show	VBN
cord-022313-2675sjlf	442	7	in	in	IN
cord-022313-2675sjlf	442	8	Fig	Fig	NNP
cord-022313-2675sjlf	442	9	.	.	.
cord-022313-2675sjlf	443	1	9	9	CD
cord-022313-2675sjlf	443	2	is	be	VBZ
cord-022313-2675sjlf	443	3	2,6-diamino-2,6-imino-7	2,6-diamino-2,6-imino-7	CD
cord-022313-2675sjlf	443	4	-	-	HYPH
cord-022313-2675sjlf	443	5	0-(^-D	0-(^-d	CD
cord-022313-2675sjlf	443	6	-	-	HYPH
cord-022313-2675sjlf	443	7	glucopyranosyl)-D	glucopyranosyl)-d	CD
cord-022313-2675sjlf	443	8	-	-	HYPH
cord-022313-2675sjlf	443	9	glycero	glycero	NN
cord-022313-2675sjlf	443	10	-	-	HYPH
cord-022313-2675sjlf	443	11	L	L	NNP
cord-022313-2675sjlf	443	12	-	-	HYPH
cord-022313-2675sjlf	443	13	guloheptitol	guloheptitol	NNP
cord-022313-2675sjlf	443	14	(	(	-LRB-
cord-022313-2675sjlf	443	15	MDL	MDL	NNP
cord-022313-2675sjlf	443	16	)	)	-RRB-
cord-022313-2675sjlf	443	17	.	.	.
cord-022313-2675sjlf	444	1	This	this	DT
cord-022313-2675sjlf	444	2	compound	compound	NN
cord-022313-2675sjlf	444	3	was	be	VBD
cord-022313-2675sjlf	444	4	chemically	chemically	RB
cord-022313-2675sjlf	444	5	synthesized	synthesize	VBN
cord-022313-2675sjlf	444	6	to	to	TO
cord-022313-2675sjlf	444	7	mimic	mimic	VB
cord-022313-2675sjlf	444	8	a	a	DT
cord-022313-2675sjlf	444	9	disaccharide	disaccharide	NN
cord-022313-2675sjlf	444	10	that	that	WDT
cord-022313-2675sjlf	444	11	would	would	MD
cord-022313-2675sjlf	444	12	act	act	VB
cord-022313-2675sjlf	444	13	as	as	IN
cord-022313-2675sjlf	444	14	a	a	DT
cord-022313-2675sjlf	444	15	transition	transition	NN
cord-022313-2675sjlf	444	16	state	state	NN
cord-022313-2675sjlf	444	17	analog	analog	NN
cord-022313-2675sjlf	444	18	of	of	IN
cord-022313-2675sjlf	444	19	the	the	DT
cord-022313-2675sjlf	444	20	intestinal	intestinal	JJ
cord-022313-2675sjlf	444	21	enzyme	enzyme	NN
cord-022313-2675sjlf	444	22	sucrase	sucrase	NN
cord-022313-2675sjlf	444	23	(	(	-LRB-
cord-022313-2675sjlf	444	24	184	184	CD
cord-022313-2675sjlf	444	25	)	)	-RRB-
cord-022313-2675sjlf	444	26	.	.	.
cord-022313-2675sjlf	445	1	As	as	IN
cord-022313-2675sjlf	445	2	anticipated	anticipate	VBN
cord-022313-2675sjlf	445	3	,	,	,
cord-022313-2675sjlf	445	4	MDL	MDL	NNP
cord-022313-2675sjlf	445	5	inhibited	inhibit	VBD
cord-022313-2675sjlf	445	6	rat	rat	NN
cord-022313-2675sjlf	445	7	intestinal	intestinal	JJ
cord-022313-2675sjlf	445	8	maltase	maltase	NN
cord-022313-2675sjlf	445	9	,	,	,
cord-022313-2675sjlf	445	10	sucrase	sucrase	NN
cord-022313-2675sjlf	445	11	,	,	,
cord-022313-2675sjlf	445	12	isomaltase	isomaltase	NNP
cord-022313-2675sjlf	445	13	,	,	,
cord-022313-2675sjlf	445	14	glucoamylase	glucoamylase	NNP
cord-022313-2675sjlf	445	15	,	,	,
cord-022313-2675sjlf	445	16	and	and	CC
cord-022313-2675sjlf	445	17	trehalase	trehalase	NN
cord-022313-2675sjlf	445	18	at	at	IN
cord-022313-2675sjlf	445	19	micromolar	micromolar	NNP
cord-022313-2675sjlf	445	20	con	con	NN
cord-022313-2675sjlf	445	21	centrations	centration	NNS
cord-022313-2675sjlf	445	22	.	.	.
cord-022313-2675sjlf	446	1	Interestingly	interestingly	RB
cord-022313-2675sjlf	446	2	enough	enough	RB
cord-022313-2675sjlf	446	3	,	,	,
cord-022313-2675sjlf	446	4	when	when	WRB
cord-022313-2675sjlf	446	5	tested	test	VBN
cord-022313-2675sjlf	446	6	on	on	IN
cord-022313-2675sjlf	446	7	the	the	DT
cord-022313-2675sjlf	446	8	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	446	9	pro	pro	JJ
cord-022313-2675sjlf	446	10	cessing	cesse	VBG
cord-022313-2675sjlf	446	11	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	446	12	,	,	,
cord-022313-2675sjlf	446	13	it	-PRON-	PRP
cord-022313-2675sjlf	446	14	was	be	VBD
cord-022313-2675sjlf	446	15	the	the	DT
cord-022313-2675sjlf	446	16	opposite	opposite	NN
cord-022313-2675sjlf	446	17	of	of	IN
cord-022313-2675sjlf	446	18	australine	australine	NN
cord-022313-2675sjlf	446	19	in	in	IN
cord-022313-2675sjlf	446	20	its	-PRON-	PRP$
cord-022313-2675sjlf	446	21	specificity	specificity	NN
cord-022313-2675sjlf	446	22	.	.	.
cord-022313-2675sjlf	447	1	That	that	DT
cord-022313-2675sjlf	447	2	is	is	RB
cord-022313-2675sjlf	447	3	,	,	,
cord-022313-2675sjlf	447	4	MDL	MDL	NNP
cord-022313-2675sjlf	447	5	was	be	VBD
cord-022313-2675sjlf	447	6	a	a	DT
cord-022313-2675sjlf	447	7	much	much	RB
cord-022313-2675sjlf	447	8	more	more	RBR
cord-022313-2675sjlf	447	9	effective	effective	JJ
cord-022313-2675sjlf	447	10	inhibitor	inhibitor	NN
cord-022313-2675sjlf	447	11	of	of	IN
cord-022313-2675sjlf	447	12	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	447	13	II	II	NNP
cord-022313-2675sjlf	447	14	than	than	IN
cord-022313-2675sjlf	447	15	it	-PRON-	PRP
cord-022313-2675sjlf	447	16	was	be	VBD
cord-022313-2675sjlf	447	17	of	of	IN
cord-022313-2675sjlf	447	18	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	447	19	I	i	NN
cord-022313-2675sjlf	447	20	(	(	-LRB-
cord-022313-2675sjlf	447	21	185	185	CD
cord-022313-2675sjlf	447	22	)	)	-RRB-
cord-022313-2675sjlf	447	23	.	.	.
cord-022313-2675sjlf	448	1	In	in	IN
cord-022313-2675sjlf	448	2	cell	cell	NN
cord-022313-2675sjlf	448	3	culture	culture	NN
cord-022313-2675sjlf	448	4	experiments	experiment	NNS
cord-022313-2675sjlf	448	5	,	,	,
cord-022313-2675sjlf	448	6	MDL	MDL	NNP
cord-022313-2675sjlf	448	7	caused	cause	VBD
cord-022313-2675sjlf	448	8	the	the	DT
cord-022313-2675sjlf	448	9	accumulation	accumulation	NN
cord-022313-2675sjlf	448	10	of	of	IN
cord-022313-2675sjlf	448	11	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	448	12	having	have	VBG
cord-022313-2675sjlf	448	13	mostly	mostly	RB
cord-022313-2675sjlf	448	14	Glc	Glc	NNP
cord-022313-2675sjlf	448	15	2	2	CD
cord-022313-2675sjlf	448	16	Man	Man	NNP
cord-022313-2675sjlf	448	17	7	7	CD
cord-022313-2675sjlf	448	18	_	_	NN
cord-022313-2675sjlf	448	19	9	9	CD
cord-022313-2675sjlf	449	1	(	(	-LRB-
cord-022313-2675sjlf	449	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	449	3	)	)	-RRB-
cord-022313-2675sjlf	449	4	2	2	CD
cord-022313-2675sjlf	449	5	structures	structure	NNS
cord-022313-2675sjlf	449	6	.	.	.
cord-022313-2675sjlf	450	1	The	the	DT
cord-022313-2675sjlf	450	2	finding	finding	NN
cord-022313-2675sjlf	450	3	that	that	IN
cord-022313-2675sjlf	450	4	australine	australine	NN
cord-022313-2675sjlf	450	5	and	and	CC
cord-022313-2675sjlf	450	6	MDL	MDL	NNP
cord-022313-2675sjlf	450	7	are	be	VBP
cord-022313-2675sjlf	450	8	more	more	RBR
cord-022313-2675sjlf	450	9	specific	specific	JJ
cord-022313-2675sjlf	450	10	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	450	11	than	than	IN
cord-022313-2675sjlf	450	12	castanospermine	castanospermine	NN
cord-022313-2675sjlf	450	13	and	and	CC
cord-022313-2675sjlf	450	14	deoxynojirimycin	deoxynojirimycin	NNS
cord-022313-2675sjlf	450	15	will	will	MD
cord-022313-2675sjlf	450	16	hopefully	hopefully	RB
cord-022313-2675sjlf	450	17	stimulate	stimulate	VB
cord-022313-2675sjlf	450	18	a	a	DT
cord-022313-2675sjlf	450	19	more	more	RBR
cord-022313-2675sjlf	450	20	intense	intense	JJ
cord-022313-2675sjlf	450	21	search	search	NN
cord-022313-2675sjlf	450	22	for	for	IN
cord-022313-2675sjlf	450	23	other	other	JJ
cord-022313-2675sjlf	450	24	naturally	naturally	RB
cord-022313-2675sjlf	450	25	occurring	occur	VBG
cord-022313-2675sjlf	450	26	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	450	27	with	with	IN
cord-022313-2675sjlf	450	28	improved	improve	VBN
cord-022313-2675sjlf	450	29	selectivity	selectivity	NN
cord-022313-2675sjlf	450	30	for	for	IN
cord-022313-2675sjlf	450	31	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	450	32	and	and	CC
cord-022313-2675sjlf	450	33	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	450	34	,	,	,
cord-022313-2675sjlf	450	35	and	and	CC
cord-022313-2675sjlf	450	36	will	will	MD
cord-022313-2675sjlf	450	37	also	also	RB
cord-022313-2675sjlf	450	38	entice	entice	VB
cord-022313-2675sjlf	450	39	chemists	chemist	NNS
cord-022313-2675sjlf	450	40	to	to	TO
cord-022313-2675sjlf	450	41	use	use	VB
cord-022313-2675sjlf	450	42	their	-PRON-	PRP$
cord-022313-2675sjlf	450	43	imagination	imagination	NN
cord-022313-2675sjlf	450	44	to	to	TO
cord-022313-2675sjlf	450	45	synthesize	synthesize	VB
cord-022313-2675sjlf	450	46	more	more	JJR
cord-022313-2675sjlf	450	47	novel	novel	JJ
cord-022313-2675sjlf	450	48	compounds	compound	NNS
cord-022313-2675sjlf	450	49	.	.	.
cord-022313-2675sjlf	451	1	The	the	DT
cord-022313-2675sjlf	451	2	first	first	JJ
cord-022313-2675sjlf	451	3	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	451	4	processing	processing	NN
cord-022313-2675sjlf	451	5	inhibitor	inhibitor	NN
cord-022313-2675sjlf	451	6	to	to	TO
cord-022313-2675sjlf	451	7	be	be	VB
cord-022313-2675sjlf	451	8	reported	report	VBN
cord-022313-2675sjlf	451	9	was	be	VBD
cord-022313-2675sjlf	451	10	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	451	11	(	(	-LRB-
cord-022313-2675sjlf	451	12	186	186	CD
cord-022313-2675sjlf	451	13	)	)	-RRB-
cord-022313-2675sjlf	451	14	,	,	,
cord-022313-2675sjlf	451	15	which	which	WDT
cord-022313-2675sjlf	451	16	is	be	VBZ
cord-022313-2675sjlf	451	17	described	describe	VBN
cord-022313-2675sjlf	451	18	in	in	IN
cord-022313-2675sjlf	451	19	more	more	JJR
cord-022313-2675sjlf	451	20	detail	detail	NN
cord-022313-2675sjlf	451	21	below	below	RB
cord-022313-2675sjlf	451	22	.	.	.
cord-022313-2675sjlf	452	1	This	this	DT
cord-022313-2675sjlf	452	2	indolizidine	indolizidine	NN
cord-022313-2675sjlf	452	3	alkaloid	alkaloid	NN
cord-022313-2675sjlf	452	4	was	be	VBD
cord-022313-2675sjlf	452	5	initially	initially	RB
cord-022313-2675sjlf	452	6	found	find	VBN
cord-022313-2675sjlf	452	7	to	to	TO
cord-022313-2675sjlf	452	8	be	be	VB
cord-022313-2675sjlf	452	9	an	an	DT
cord-022313-2675sjlf	452	10	inhibitor	inhibitor	NN
cord-022313-2675sjlf	452	11	of	of	IN
cord-022313-2675sjlf	452	12	lysosomal	lysosomal	NN
cord-022313-2675sjlf	452	13	and	and	CC
cord-022313-2675sjlf	452	14	arylmannosidases	arylmannosidase	NNS
cord-022313-2675sjlf	452	15	(	(	-LRB-
cord-022313-2675sjlf	452	16	187	187	CD
cord-022313-2675sjlf	452	17	)	)	-RRB-
cord-022313-2675sjlf	452	18	,	,	,
cord-022313-2675sjlf	452	19	and	and	CC
cord-022313-2675sjlf	452	20	was	be	VBD
cord-022313-2675sjlf	452	21	later	later	RB
cord-022313-2675sjlf	452	22	shown	show	VBN
cord-022313-2675sjlf	452	23	to	to	TO
cord-022313-2675sjlf	452	24	specifically	specifically	RB
cord-022313-2675sjlf	452	25	inhibit	inhibit	VB
cord-022313-2675sjlf	452	26	the	the	DT
cord-022313-2675sjlf	452	27	processing	processing	NN
cord-022313-2675sjlf	452	28	mannosidase	mannosidase	NN
cord-022313-2675sjlf	452	29	II	II	NNP
cord-022313-2675sjlf	452	30	(	(	-LRB-
cord-022313-2675sjlf	452	31	188	188	CD
cord-022313-2675sjlf	452	32	)	)	-RRB-
cord-022313-2675sjlf	452	33	.	.	.
cord-022313-2675sjlf	453	1	However	however	RB
cord-022313-2675sjlf	453	2	,	,	,
cord-022313-2675sjlf	453	3	for	for	IN
cord-022313-2675sjlf	453	4	ease	ease	NN
cord-022313-2675sjlf	453	5	of	of	IN
cord-022313-2675sjlf	453	6	understanding	understanding	NN
cord-022313-2675sjlf	453	7	,	,	,
cord-022313-2675sjlf	453	8	I	-PRON-	PRP
cord-022313-2675sjlf	453	9	will	will	MD
cord-022313-2675sjlf	453	10	consider	consider	VB
cord-022313-2675sjlf	453	11	the	the	DT
cord-022313-2675sjlf	453	12	various	various	JJ
cord-022313-2675sjlf	453	13	mannosidase	mannosidase	NN
cord-022313-2675sjlf	453	14	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	453	15	in	in	IN
cord-022313-2675sjlf	453	16	the	the	DT
cord-022313-2675sjlf	453	17	order	order	NN
cord-022313-2675sjlf	453	18	in	in	IN
cord-022313-2675sjlf	453	19	which	which	WDT
cord-022313-2675sjlf	453	20	they	-PRON-	PRP
cord-022313-2675sjlf	453	21	occur	occur	VBP
cord-022313-2675sjlf	453	22	in	in	IN
cord-022313-2675sjlf	453	23	the	the	DT
cord-022313-2675sjlf	453	24	processing	processing	NN
cord-022313-2675sjlf	453	25	pathway	pathway	NN
cord-022313-2675sjlf	453	26	rather	rather	RB
cord-022313-2675sjlf	453	27	than	than	IN
cord-022313-2675sjlf	453	28	in	in	IN
cord-022313-2675sjlf	453	29	the	the	DT
cord-022313-2675sjlf	453	30	order	order	NN
cord-022313-2675sjlf	453	31	in	in	IN
cord-022313-2675sjlf	453	32	which	which	WDT
cord-022313-2675sjlf	453	33	they	-PRON-	PRP
cord-022313-2675sjlf	453	34	were	be	VBD
cord-022313-2675sjlf	453	35	first	first	RB
cord-022313-2675sjlf	453	36	reported	report	VBN
cord-022313-2675sjlf	453	37	.	.	.
cord-022313-2675sjlf	454	1	The	the	DT
cord-022313-2675sjlf	454	2	discovery	discovery	NN
cord-022313-2675sjlf	454	3	of	of	IN
cord-022313-2675sjlf	454	4	deoxynojirimycin	deoxynojirimycin	NNS
cord-022313-2675sjlf	454	5	and	and	CC
cord-022313-2675sjlf	454	6	castanospermine	castanospermine	NN
cord-022313-2675sjlf	454	7	as	as	IN
cord-022313-2675sjlf	454	8	glycopro	glycopro	NNP
cord-022313-2675sjlf	454	9	tein	tein	NNP
cord-022313-2675sjlf	454	10	processing	processing	NN
cord-022313-2675sjlf	454	11	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	454	12	indicated	indicate	VBD
cord-022313-2675sjlf	454	13	that	that	IN
cord-022313-2675sjlf	454	14	a	a	DT
cord-022313-2675sjlf	454	15	good	good	JJ
cord-022313-2675sjlf	454	16	glycosidase	glycosidase	JJ
cord-022313-2675sjlf	454	17	inhibitor	inhibitor	NN
cord-022313-2675sjlf	454	18	should	should	MD
cord-022313-2675sjlf	454	19	possess	possess	VB
cord-022313-2675sjlf	454	20	the	the	DT
cord-022313-2675sjlf	454	21	following	follow	VBG
cord-022313-2675sjlf	454	22	properties	property	NNS
cord-022313-2675sjlf	454	23	:	:	:
cord-022313-2675sjlf	454	24	(	(	-LRB-
cord-022313-2675sjlf	454	25	a	a	LS
cord-022313-2675sjlf	454	26	)	)	-RRB-
cord-022313-2675sjlf	454	27	a	a	DT
cord-022313-2675sjlf	454	28	pyranose	pyranose	NN
cord-022313-2675sjlf	454	29	ring	ring	NN
cord-022313-2675sjlf	454	30	structure	structure	NN
cord-022313-2675sjlf	454	31	with	with	IN
cord-022313-2675sjlf	454	32	a	a	DT
cord-022313-2675sjlf	454	33	nitrogen	nitrogen	NN
cord-022313-2675sjlf	454	34	in	in	IN
cord-022313-2675sjlf	454	35	the	the	DT
cord-022313-2675sjlf	454	36	ring	ring	NN
cord-022313-2675sjlf	454	37	replacing	replace	VBG
cord-022313-2675sjlf	454	38	the	the	DT
cord-022313-2675sjlf	454	39	oxygen	oxygen	NN
cord-022313-2675sjlf	454	40	and	and	CC
cord-022313-2675sjlf	454	41	(	(	-LRB-
cord-022313-2675sjlf	454	42	b	b	NN
cord-022313-2675sjlf	454	43	)	)	-RRB-
cord-022313-2675sjlf	454	44	the	the	DT
cord-022313-2675sjlf	454	45	stereochem	stereochem	NNP
cord-022313-2675sjlf	454	46	istry	istry	NNP
cord-022313-2675sjlf	454	47	of	of	IN
cord-022313-2675sjlf	454	48	the	the	DT
cord-022313-2675sjlf	454	49	hydroxyl	hydroxyl	NN
cord-022313-2675sjlf	454	50	groups	group	NNS
cord-022313-2675sjlf	454	51	in	in	IN
cord-022313-2675sjlf	454	52	keeping	keep	VBG
cord-022313-2675sjlf	454	53	with	with	IN
cord-022313-2675sjlf	454	54	those	those	DT
cord-022313-2675sjlf	454	55	of	of	IN
cord-022313-2675sjlf	454	56	the	the	DT
cord-022313-2675sjlf	454	57	particular	particular	JJ
cord-022313-2675sjlf	454	58	sugar	sugar	NN
cord-022313-2675sjlf	454	59	that	that	WDT
cord-022313-2675sjlf	454	60	is	be	VBZ
cord-022313-2675sjlf	454	61	recognized	recognize	VBN
cord-022313-2675sjlf	454	62	by	by	IN
cord-022313-2675sjlf	454	63	the	the	DT
cord-022313-2675sjlf	454	64	glycosidase	glycosidase	NN
cord-022313-2675sjlf	454	65	of	of	IN
cord-022313-2675sjlf	454	66	interest	interest	NN
cord-022313-2675sjlf	454	67	.	.	.
cord-022313-2675sjlf	455	1	Thus	thus	RB
cord-022313-2675sjlf	455	2	,	,	,
cord-022313-2675sjlf	455	3	it	-PRON-	PRP
cord-022313-2675sjlf	455	4	was	be	VBD
cord-022313-2675sjlf	455	5	reasonable	reasonable	JJ
cord-022313-2675sjlf	455	6	to	to	TO
cord-022313-2675sjlf	455	7	assume	assume	VB
cord-022313-2675sjlf	455	8	that	that	IN
cord-022313-2675sjlf	455	9	a	a	DT
cord-022313-2675sjlf	455	10	structure	structure	NN
cord-022313-2675sjlf	455	11	similar	similar	JJ
cord-022313-2675sjlf	455	12	to	to	IN
cord-022313-2675sjlf	455	13	deoxynojirimycin	deoxynojirimycin	NNS
cord-022313-2675sjlf	455	14	but	but	CC
cord-022313-2675sjlf	455	15	with	with	IN
cord-022313-2675sjlf	455	16	the	the	DT
cord-022313-2675sjlf	455	17	mannose	mannose	NN
cord-022313-2675sjlf	455	18	configuration	configuration	NN
cord-022313-2675sjlf	455	19	(	(	-LRB-
cord-022313-2675sjlf	455	20	i.e.	i.e.	FW
cord-022313-2675sjlf	455	21	,	,	,
cord-022313-2675sjlf	455	22	the	the	DT
cord-022313-2675sjlf	455	23	2-epimer	2-epimer	CD
cord-022313-2675sjlf	455	24	)	)	-RRB-
cord-022313-2675sjlf	455	25	should	should	MD
cord-022313-2675sjlf	455	26	be	be	VB
cord-022313-2675sjlf	455	27	a	a	DT
cord-022313-2675sjlf	455	28	good	good	JJ
cord-022313-2675sjlf	455	29	inhibitor	inhibitor	NN
cord-022313-2675sjlf	455	30	of	of	IN
cord-022313-2675sjlf	455	31	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	455	32	.	.	.
cord-022313-2675sjlf	456	1	The	the	DT
cord-022313-2675sjlf	456	2	2-epimer	2-epimer	CD
cord-022313-2675sjlf	456	3	of	of	IN
cord-022313-2675sjlf	456	4	deoxynojirimycin	deoxynojirimycin	NNS
cord-022313-2675sjlf	456	5	was	be	VBD
cord-022313-2675sjlf	456	6	syn	syn	NN
cord-022313-2675sjlf	456	7	thesized	thesize	VBN
cord-022313-2675sjlf	456	8	chemically	chemically	RB
cord-022313-2675sjlf	456	9	and	and	CC
cord-022313-2675sjlf	456	10	was	be	VBD
cord-022313-2675sjlf	456	11	indeed	indeed	RB
cord-022313-2675sjlf	456	12	found	find	VBN
cord-022313-2675sjlf	456	13	to	to	TO
cord-022313-2675sjlf	456	14	be	be	VB
cord-022313-2675sjlf	456	15	a	a	DT
cord-022313-2675sjlf	456	16	potent	potent	JJ
cord-022313-2675sjlf	456	17	inhibitor	inhibitor	NN
cord-022313-2675sjlf	456	18	of	of	IN
cord-022313-2675sjlf	456	19	the	the	DT
cord-022313-2675sjlf	456	20	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	456	21	processing	processing	NN
cord-022313-2675sjlf	456	22	enzyme	enzyme	NN
cord-022313-2675sjlf	457	1	mannosidase	mannosidase	NNP
cord-022313-2675sjlf	457	2	I	-PRON-	PRP
cord-022313-2675sjlf	457	3	(	(	-LRB-
cord-022313-2675sjlf	457	4	189	189	CD
cord-022313-2675sjlf	457	5	)	)	-RRB-
cord-022313-2675sjlf	457	6	.	.	.
cord-022313-2675sjlf	458	1	Surprisingly	surprisingly	RB
cord-022313-2675sjlf	458	2	enough	enough	RB
cord-022313-2675sjlf	458	3	,	,	,
cord-022313-2675sjlf	458	4	deoxymannojirimycin	deoxymannojirimycin	NNP
cord-022313-2675sjlf	458	5	d	d	NNP
cord-022313-2675sjlf	458	6	d	d	NNP
cord-022313-2675sjlf	458	7	not	not	RB
cord-022313-2675sjlf	458	8	inhibit	inhibit	VB
cord-022313-2675sjlf	458	9	jack	jack	NN
cord-022313-2675sjlf	458	10	bean	bean	NN
cord-022313-2675sjlf	458	11	or	or	CC
cord-022313-2675sjlf	458	12	lysosomal	lysosomal	NN
cord-022313-2675sjlf	458	13	α	α	NN
cord-022313-2675sjlf	458	14	-	-	HYPH
cord-022313-2675sjlf	458	15	mannosidase	mannosidase	NN
cord-022313-2675sjlf	458	16	,	,	,
cord-022313-2675sjlf	458	17	nor	nor	CC
cord-022313-2675sjlf	458	18	did	do	VBD
cord-022313-2675sjlf	458	19	it	-PRON-	PRP
cord-022313-2675sjlf	458	20	inhibit	inhibit	VB
cord-022313-2675sjlf	458	21	che	che	NNP
cord-022313-2675sjlf	458	22	processing	process	VBG
cord-022313-2675sjlf	458	23	mannosidase	mannosidase	NN
cord-022313-2675sjlf	458	24	II	II	NNP
cord-022313-2675sjlf	458	25	.	.	.
cord-022313-2675sjlf	459	1	In	in	IN
cord-022313-2675sjlf	459	2	fact	fact	NN
cord-022313-2675sjlf	459	3	,	,	,
cord-022313-2675sjlf	459	4	this	this	DT
cord-022313-2675sjlf	459	5	inhibitor	inhibitor	NN
cord-022313-2675sjlf	459	6	demonstrates	demonstrate	VBZ
cord-022313-2675sjlf	459	7	thai	thai	NNP
cord-022313-2675sjlf	459	8	,	,	,
cord-022313-2675sjlf	459	9	it	-PRON-	PRP
cord-022313-2675sjlf	459	10	is	be	VBZ
cord-022313-2675sjlf	459	11	dangerous	dangerous	JJ
cord-022313-2675sjlf	459	12	to	to	TO
cord-022313-2675sjlf	459	13	screen	screen	NN
cord-022313-2675sjlf	459	14	for	for	IN
cord-022313-2675sjlf	459	15	new	new	JJ
cord-022313-2675sjlf	459	16	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	459	17	using	use	VBG
cord-022313-2675sjlf	459	18	aryl	aryl	NN
cord-022313-2675sjlf	459	19	-	-	HYPH
cord-022313-2675sjlf	459	20	glycosidases	glycosidase	NNS
cord-022313-2675sjlf	459	21	as	as	IN
cord-022313-2675sjlf	459	22	the	the	DT
cord-022313-2675sjlf	459	23	source	source	NN
cord-022313-2675sjlf	459	24	of	of	IN
cord-022313-2675sjlf	459	25	enzymes	enzyme	NNS
cord-022313-2675sjlf	459	26	or	or	CC
cord-022313-2675sjlf	459	27	even	even	RB
cord-022313-2675sjlf	459	28	using	use	VBG
cord-022313-2675sjlf	459	29	only	only	RB
cord-022313-2675sjlf	459	30	a	a	DT
cord-022313-2675sjlf	459	31	few	few	JJ
cord-022313-2675sjlf	459	32	of	of	IN
cord-022313-2675sjlf	459	33	the	the	DT
cord-022313-2675sjlf	459	34	processing	processing	NN
cord-022313-2675sjlf	459	35	enzymes	enzyme	NNS
cord-022313-2675sjlf	459	36	,	,	,
cord-022313-2675sjlf	459	37	because	because	IN
cord-022313-2675sjlf	459	38	the	the	DT
cord-022313-2675sjlf	459	39	most	most	RBS
cord-022313-2675sjlf	459	40	useful	useful	JJ
cord-022313-2675sjlf	459	41	and	and	CC
cord-022313-2675sjlf	459	42	desirable	desirable	JJ
cord-022313-2675sjlf	459	43	processing	processing	NN
cord-022313-2675sjlf	459	44	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	459	45	will	will	MD
cord-022313-2675sjlf	459	46	be	be	VB
cord-022313-2675sjlf	459	47	specific	specific	JJ
cord-022313-2675sjlf	459	48	for	for	IN
cord-022313-2675sjlf	459	49	a	a	DT
cord-022313-2675sjlf	459	50	particular	particular	JJ
cord-022313-2675sjlf	459	51	processing	processing	NN
cord-022313-2675sjlf	459	52	glycosidase	glycosidase	NN
cord-022313-2675sjlf	459	53	and	and	CC
cord-022313-2675sjlf	459	54	may	may	MD
cord-022313-2675sjlf	459	55	not	not	RB
cord-022313-2675sjlf	459	56	inhibit	inhibit	VB
cord-022313-2675sjlf	459	57	these	these	DT
cord-022313-2675sjlf	459	58	other	other	JJ
cord-022313-2675sjlf	459	59	activities	activity	NNS
cord-022313-2675sjlf	459	60	.	.	.
cord-022313-2675sjlf	460	1	The	the	DT
cord-022313-2675sjlf	460	2	structures	structure	NNS
cord-022313-2675sjlf	460	3	of	of	IN
cord-022313-2675sjlf	460	4	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	460	5	,	,	,
cord-022313-2675sjlf	460	6	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	460	7	,	,	,
cord-022313-2675sjlf	460	8	and	and	CC
cord-022313-2675sjlf	460	9	other	other	JJ
cord-022313-2675sjlf	460	10	known	know	VBN
cord-022313-2675sjlf	460	11	mannosidase	mannosidase	NN
cord-022313-2675sjlf	460	12	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	460	13	are	be	VBP
cord-022313-2675sjlf	460	14	shown	show	VBN
cord-022313-2675sjlf	460	15	in	in	IN
cord-022313-2675sjlf	460	16	Fig	Fig	NNP
cord-022313-2675sjlf	460	17	.	.	.
cord-022313-2675sjlf	461	1	10	10	CD
cord-022313-2675sjlf	461	2	.	.	.
cord-022313-2675sjlf	462	1	Since	since	IN
cord-022313-2675sjlf	462	2	the	the	DT
cord-022313-2675sjlf	462	3	time	time	NN
cord-022313-2675sjlf	462	4	when	when	WRB
cord-022313-2675sjlf	462	5	many	many	JJ
cord-022313-2675sjlf	462	6	of	of	IN
cord-022313-2675sjlf	462	7	the	the	DT
cord-022313-2675sjlf	462	8	studies	study	NNS
cord-022313-2675sjlf	462	9	on	on	IN
cord-022313-2675sjlf	462	10	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	462	11	were	be	VBD
cord-022313-2675sjlf	462	12	done	do	VBN
cord-022313-2675sjlf	462	13	,	,	,
cord-022313-2675sjlf	462	14	several	several	JJ
cord-022313-2675sjlf	462	15	other	other	JJ
cord-022313-2675sjlf	462	16	neutral	neutral	JJ
cord-022313-2675sjlf	462	17	α	α	NN
cord-022313-2675sjlf	462	18	-	-	HYPH
cord-022313-2675sjlf	462	19	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	462	20	that	that	WDT
cord-022313-2675sjlf	462	21	have	have	VBP
cord-022313-2675sjlf	462	22	different	different	JJ
cord-022313-2675sjlf	462	23	specificities	specificity	NNS
cord-022313-2675sjlf	462	24	and	and	CC
cord-022313-2675sjlf	462	25	are	be	VBP
cord-022313-2675sjlf	462	26	enzymes	enzyme	NNS
cord-022313-2675sjlf	462	27	distinct	distinct	JJ
cord-022313-2675sjlf	462	28	from	from	IN
cord-022313-2675sjlf	462	29	mannosidase	mannosidase	NN
cord-022313-2675sjlf	463	1	I	-PRON-	PRP
cord-022313-2675sjlf	463	2	or	or	CC
cord-022313-2675sjlf	463	3	mannosidase	mannosidase	NN
cord-022313-2675sjlf	463	4	II	ii	CD
cord-022313-2675sjlf	463	5	have	have	VBP
cord-022313-2675sjlf	463	6	been	be	VBN
cord-022313-2675sjlf	463	7	identified	identify	VBN
cord-022313-2675sjlf	463	8	.	.	.
cord-022313-2675sjlf	464	1	Some	some	DT
cord-022313-2675sjlf	464	2	of	of	IN
cord-022313-2675sjlf	464	3	these	these	DT
cord-022313-2675sjlf	464	4	enzymes	enzyme	NNS
cord-022313-2675sjlf	464	5	have	have	VBP
cord-022313-2675sjlf	464	6	been	be	VBN
cord-022313-2675sjlf	464	7	found	find	VBN
cord-022313-2675sjlf	464	8	to	to	TO
cord-022313-2675sjlf	464	9	be	be	VB
cord-022313-2675sjlf	464	10	resistant	resistant	JJ
cord-022313-2675sjlf	464	11	to	to	IN
cord-022313-2675sjlf	464	12	inhibition	inhibition	NN
cord-022313-2675sjlf	464	13	by	by	IN
cord-022313-2675sjlf	464	14	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	464	15	,	,	,
cord-022313-2675sjlf	464	16	but	but	CC
cord-022313-2675sjlf	464	17	there	there	EX
cord-022313-2675sjlf	464	18	are	be	VBP
cord-022313-2675sjlf	464	19	not	not	RB
cord-022313-2675sjlf	464	20	enough	enough	JJ
cord-022313-2675sjlf	464	21	mannosi	mannosi	NNP
cord-022313-2675sjlf	464	22	dase	dase	NNP
cord-022313-2675sjlf	464	23	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	464	24	yet	yet	RB
cord-022313-2675sjlf	464	25	known	know	VBN
cord-022313-2675sjlf	464	26	to	to	TO
cord-022313-2675sjlf	464	27	be	be	VB
cord-022313-2675sjlf	464	28	able	able	JJ
cord-022313-2675sjlf	464	29	to	to	TO
cord-022313-2675sjlf	464	30	specifically	specifically	RB
cord-022313-2675sjlf	464	31	inhibit	inhibit	VB
cord-022313-2675sjlf	464	32	some	some	DT
cord-022313-2675sjlf	464	33	of	of	IN
cord-022313-2675sjlf	464	34	these	these	DT
cord-022313-2675sjlf	464	35	activities	activity	NNS
cord-022313-2675sjlf	464	36	.	.	.
cord-022313-2675sjlf	465	1	In	in	IN
cord-022313-2675sjlf	465	2	addition	addition	NN
cord-022313-2675sjlf	465	3	,	,	,
cord-022313-2675sjlf	465	4	most	most	JJS
cord-022313-2675sjlf	465	5	of	of	IN
cord-022313-2675sjlf	465	6	these	these	DT
cord-022313-2675sjlf	465	7	other	other	JJ
cord-022313-2675sjlf	465	8	enzymes	enzyme	NNS
cord-022313-2675sjlf	465	9	have	have	VBP
cord-022313-2675sjlf	465	10	not	not	RB
cord-022313-2675sjlf	465	11	yet	yet	RB
cord-022313-2675sjlf	465	12	been	be	VBN
cord-022313-2675sjlf	465	13	purified	purify	VBN
cord-022313-2675sjlf	465	14	,	,	,
cord-022313-2675sjlf	465	15	so	so	IN
cord-022313-2675sjlf	465	16	they	-PRON-	PRP
cord-022313-2675sjlf	465	17	have	have	VBP
cord-022313-2675sjlf	465	18	not	not	RB
cord-022313-2675sjlf	465	19	been	be	VBN
cord-022313-2675sjlf	465	20	tested	test	VBN
cord-022313-2675sjlf	465	21	against	against	IN
cord-022313-2675sjlf	465	22	the	the	DT
cord-022313-2675sjlf	465	23	various	various	JJ
cord-022313-2675sjlf	465	24	processing	processing	NN
cord-022313-2675sjlf	465	25	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	465	26	.	.	.
cord-022313-2675sjlf	466	1	In	in	IN
cord-022313-2675sjlf	466	2	animal	animal	NN
cord-022313-2675sjlf	466	3	cells	cell	NNS
cord-022313-2675sjlf	466	4	,	,	,
cord-022313-2675sjlf	466	5	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	466	6	inhibited	inhibit	VBD
cord-022313-2675sjlf	466	7	the	the	DT
cord-022313-2675sjlf	466	8	Golgi	Golgi	NNP
cord-022313-2675sjlf	466	9	mannosidase	mannosidase	NN
cord-022313-2675sjlf	466	10	IA	IA	NNP
cord-022313-2675sjlf	466	11	/	/	SYM
cord-022313-2675sjlf	466	12	B	B	NNP
cord-022313-2675sjlf	466	13	and	and	CC
cord-022313-2675sjlf	466	14	caused	cause	VBD
cord-022313-2675sjlf	466	15	the	the	DT
cord-022313-2675sjlf	466	16	accumulation	accumulation	NN
cord-022313-2675sjlf	466	17	of	of	IN
cord-022313-2675sjlf	466	18	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	466	19	hav	hav	VBP
cord-022313-2675sjlf	466	20	ing	ing	DT
cord-022313-2675sjlf	466	21	high	high	JJ
cord-022313-2675sjlf	466	22	-	-	HYPH
cord-022313-2675sjlf	466	23	mannose	mannose	NN
cord-022313-2675sjlf	466	24	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	466	25	,	,	,
cord-022313-2675sjlf	466	26	mostly	mostly	RB
cord-022313-2675sjlf	466	27	of	of	IN
cord-022313-2675sjlf	466	28	the	the	DT
cord-022313-2675sjlf	466	29	Man	Man	NNP
cord-022313-2675sjlf	466	30	8	8	CD
cord-022313-2675sjlf	466	31	.	.	.
cord-022313-2675sjlf	467	1	9	9	LS
cord-022313-2675sjlf	467	2	(	(	-LRB-
cord-022313-2675sjlf	467	3	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	467	4	)	)	-RRB-
cord-022313-2675sjlf	467	5	2	2	CD
cord-022313-2675sjlf	467	6	structure	structure	NN
cord-022313-2675sjlf	467	7	(	(	-LRB-
cord-022313-2675sjlf	467	8	191	191	CD
cord-022313-2675sjlf	467	9	)	)	-RRB-
cord-022313-2675sjlf	467	10	.	.	.
cord-022313-2675sjlf	468	1	This	this	DT
cord-022313-2675sjlf	468	2	inhibitor	inhibitor	NN
cord-022313-2675sjlf	468	3	,	,	,
cord-022313-2675sjlf	468	4	however	however	RB
cord-022313-2675sjlf	468	5	,	,	,
cord-022313-2675sjlf	468	6	did	do	VBD
cord-022313-2675sjlf	468	7	not	not	RB
cord-022313-2675sjlf	468	8	prevent	prevent	VB
cord-022313-2675sjlf	468	9	the	the	DT
cord-022313-2675sjlf	468	10	secretion	secretion	NN
cord-022313-2675sjlf	468	11	of	of	IN
cord-022313-2675sjlf	468	12	IgD	IgD	NNP
cord-022313-2675sjlf	468	13	or	or	CC
cord-022313-2675sjlf	468	14	IgM	IgM	NNP
cord-022313-2675sjlf	468	15	in	in	IN
cord-022313-2675sjlf	468	16	cell	cell	NN
cord-022313-2675sjlf	468	17	culture	culture	NN
cord-022313-2675sjlf	468	18	,	,	,
cord-022313-2675sjlf	468	19	although	although	IN
cord-022313-2675sjlf	468	20	the	the	DT
cord-022313-2675sjlf	468	21	glucose	glucose	NN
cord-022313-2675sjlf	468	22	analog	analog	NN
cord-022313-2675sjlf	468	23	deoxynojiri	deoxynojiri	NNP
cord-022313-2675sjlf	468	24	mycin	mycin	NNP
cord-022313-2675sjlf	468	25	did	do	VBD
cord-022313-2675sjlf	468	26	(	(	-LRB-
cord-022313-2675sjlf	468	27	192	192	CD
cord-022313-2675sjlf	468	28	)	)	-RRB-
cord-022313-2675sjlf	468	29	.	.	.
cord-022313-2675sjlf	469	1	Thus	thus	RB
cord-022313-2675sjlf	469	2	the	the	DT
cord-022313-2675sjlf	469	3	presence	presence	NN
cord-022313-2675sjlf	469	4	of	of	IN
cord-022313-2675sjlf	469	5	glucose	glucose	NN
cord-022313-2675sjlf	469	6	on	on	IN
cord-022313-2675sjlf	469	7	the	the	DT
cord-022313-2675sjlf	469	8	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	469	9	does	do	VBZ
cord-022313-2675sjlf	469	10	have	have	VB
cord-022313-2675sjlf	469	11	a	a	DT
cord-022313-2675sjlf	469	12	significant	significant	JJ
cord-022313-2675sjlf	469	13	effect	effect	NN
cord-022313-2675sjlf	469	14	on	on	IN
cord-022313-2675sjlf	469	15	the	the	DT
cord-022313-2675sjlf	469	16	intracellular	intracellular	JJ
cord-022313-2675sjlf	469	17	transport	transport	NN
cord-022313-2675sjlf	469	18	of	of	IN
cord-022313-2675sjlf	469	19	at	at	IN
cord-022313-2675sjlf	469	20	least	least	JJS
cord-022313-2675sjlf	469	21	some	some	DT
cord-022313-2675sjlf	469	22	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	469	23	,	,	,
cord-022313-2675sjlf	469	24	but	but	CC
cord-022313-2675sjlf	469	25	the	the	DT
cord-022313-2675sjlf	469	26	presence	presence	NN
cord-022313-2675sjlf	469	27	of	of	IN
cord-022313-2675sjlf	469	28	high	high	JJ
cord-022313-2675sjlf	469	29	-	-	HYPH
cord-022313-2675sjlf	469	30	mannose	mannose	NN
cord-022313-2675sjlf	469	31	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	469	32	rather	rather	RB
cord-022313-2675sjlf	469	33	than	than	IN
cord-022313-2675sjlf	469	34	the	the	DT
cord-022313-2675sjlf	469	35	normal	normal	JJ
cord-022313-2675sjlf	469	36	complex	complex	JJ
cord-022313-2675sjlf	469	37	chains	chain	NNS
cord-022313-2675sjlf	469	38	does	do	VBZ
cord-022313-2675sjlf	469	39	not	not	RB
cord-022313-2675sjlf	469	40	appear	appear	VB
cord-022313-2675sjlf	469	41	to	to	TO
cord-022313-2675sjlf	469	42	be	be	VB
cord-022313-2675sjlf	469	43	a	a	DT
cord-022313-2675sjlf	469	44	problem	problem	NN
cord-022313-2675sjlf	469	45	in	in	IN
cord-022313-2675sjlf	469	46	terms	term	NNS
cord-022313-2675sjlf	469	47	of	of	IN
cord-022313-2675sjlf	469	48	protein	protein	NN
cord-022313-2675sjlf	469	49	secretion	secretion	NN
cord-022313-2675sjlf	469	50	.	.	.
cord-022313-2675sjlf	470	1	Deoxymannojirimycin	Deoxymannojirimycin	NNP
cord-022313-2675sjlf	470	2	was	be	VBD
cord-022313-2675sjlf	470	3	also	also	RB
cord-022313-2675sjlf	470	4	without	without	IN
cord-022313-2675sjlf	470	5	effect	effect	NN
cord-022313-2675sjlf	470	6	on	on	IN
cord-022313-2675sjlf	470	7	the	the	DT
cord-022313-2675sjlf	470	8	formation	formation	NN
cord-022313-2675sjlf	470	9	and	and	CC
cord-022313-2675sjlf	470	10	appearance	appearance	NN
cord-022313-2675sjlf	470	11	of	of	IN
cord-022313-2675sjlf	470	12	the	the	DT
cord-022313-2675sjlf	470	13	G	g	NN
cord-022313-2675sjlf	470	14	protein	protein	NN
cord-022313-2675sjlf	470	15	of	of	IN
cord-022313-2675sjlf	470	16	vesicular	vesicular	JJ
cord-022313-2675sjlf	470	17	stomatitis	stomatitis	NN
cord-022313-2675sjlf	470	18	virus	virus	NN
cord-022313-2675sjlf	470	19	,	,	,
cord-022313-2675sjlf	470	20	the	the	DT
cord-022313-2675sjlf	470	21	hemagglutinin	hemagglutinin	NN
cord-022313-2675sjlf	470	22	of	of	IN
cord-022313-2675sjlf	470	23	influenza	influenza	NN
cord-022313-2675sjlf	470	24	virus	virus	NN
cord-022313-2675sjlf	470	25	,	,	,
cord-022313-2675sjlf	470	26	and	and	CC
cord-022313-2675sjlf	470	27	the	the	DT
cord-022313-2675sjlf	470	28	HLA	HLA	NNP
cord-022313-2675sjlf	470	29	A	A	NNP
cord-022313-2675sjlf	470	30	,	,	,
cord-022313-2675sjlf	470	31	B	b	NN
cord-022313-2675sjlf	470	32	,	,	,
cord-022313-2675sjlf	470	33	and	and	CC
cord-022313-2675sjlf	470	34	C	c	NN
cord-022313-2675sjlf	470	35	antigens	antigen	NNS
cord-022313-2675sjlf	470	36	,	,	,
cord-022313-2675sjlf	470	37	as	as	RB
cord-022313-2675sjlf	470	38	well	well	RB
cord-022313-2675sjlf	470	39	as	as	IN
cord-022313-2675sjlf	470	40	on	on	IN
cord-022313-2675sjlf	470	41	a	a	DT
cord-022313-2675sjlf	470	42	r	r	NN
cord-022313-2675sjlf	470	43	aeid	aeid	NN
cord-022313-2675sjlf	470	44	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	470	45	and	and	CC
cord-022313-2675sjlf	470	46	a	a	DT
cord-022313-2675sjlf	470	47	r	r	NN
cord-022313-2675sjlf	470	48	protease	protease	NN
cord-022313-2675sjlf	470	49	inhibitor	inhibitor	NN
cord-022313-2675sjlf	470	50	(	(	-LRB-
cord-022313-2675sjlf	470	51	192	192	CD
cord-022313-2675sjlf	470	52	)	)	-RRB-
cord-022313-2675sjlf	470	53	.	.	.
cord-022313-2675sjlf	471	1	Deoxymannojirimycin	Deoxymannojirimycin	NNP
cord-022313-2675sjlf	471	2	was	be	VBD
cord-022313-2675sjlf	471	3	used	use	VBN
cord-022313-2675sjlf	471	4	in	in	IN
cord-022313-2675sjlf	471	5	one	one	CD
cord-022313-2675sjlf	471	6	study	study	NN
cord-022313-2675sjlf	471	7	to	to	TO
cord-022313-2675sjlf	471	8	determine	determine	VB
cord-022313-2675sjlf	471	9	if	if	IN
cord-022313-2675sjlf	471	10	mem	mem	NNP
cord-022313-2675sjlf	471	11	brane	brane	NN
cord-022313-2675sjlf	471	12	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	471	13	were	be	VBD
cord-022313-2675sjlf	471	14	recycled	recycle	VBN
cord-022313-2675sjlf	471	15	through	through	IN
cord-022313-2675sjlf	471	16	the	the	DT
cord-022313-2675sjlf	471	17	Golgi	Golgi	NNP
cord-022313-2675sjlf	471	18	apparatus	apparatus	NN
cord-022313-2675sjlf	471	19	during	during	IN
cord-022313-2675sjlf	471	20	the	the	DT
cord-022313-2675sjlf	471	21	endocytic	endocytic	JJ
cord-022313-2675sjlf	471	22	process	process	NN
cord-022313-2675sjlf	471	23	.	.	.
cord-022313-2675sjlf	472	1	In	in	IN
cord-022313-2675sjlf	472	2	this	this	DT
cord-022313-2675sjlf	472	3	experiment	experiment	NN
cord-022313-2675sjlf	472	4	,	,	,
cord-022313-2675sjlf	472	5	membrane	membrane	NN
cord-022313-2675sjlf	472	6	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	472	7	were	be	VBD
cord-022313-2675sjlf	472	8	synthesized	synthesize	VBN
cord-022313-2675sjlf	472	9	and	and	CC
cord-022313-2675sjlf	472	10	labeled	label	VBN
cord-022313-2675sjlf	472	11	with	with	IN
cord-022313-2675sjlf	472	12	[	[	-LRB-
cord-022313-2675sjlf	472	13	3	3	CD
cord-022313-2675sjlf	472	14	H]mannose	H]mannose	NNP
cord-022313-2675sjlf	472	15	in	in	IN
cord-022313-2675sjlf	472	16	the	the	DT
cord-022313-2675sjlf	472	17	presence	presence	NN
cord-022313-2675sjlf	472	18	of	of	IN
cord-022313-2675sjlf	472	19	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	472	20	so	so	IN
cord-022313-2675sjlf	472	21	that	that	IN
cord-022313-2675sjlf	472	22	the	the	DT
cord-022313-2675sjlf	472	23	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	472	24	would	would	MD
cord-022313-2675sjlf	472	25	all	all	DT
cord-022313-2675sjlf	472	26	have	have	VB
cord-022313-2675sjlf	472	27	highmannose	highmannose	JJ
cord-022313-2675sjlf	472	28	structures	structure	NNS
cord-022313-2675sjlf	472	29	.	.	.
cord-022313-2675sjlf	473	1	Then	then	RB
cord-022313-2675sjlf	473	2	the	the	DT
cord-022313-2675sjlf	473	3	inhibitor	inhibitor	NN
cord-022313-2675sjlf	473	4	and	and	CC
cord-022313-2675sjlf	473	5	labeled	label	VBN
cord-022313-2675sjlf	473	6	sugar	sugar	NN
cord-022313-2675sjlf	473	7	were	be	VBD
cord-022313-2675sjlf	473	8	re	re	VBN
cord-022313-2675sjlf	473	9	moved	move	VBN
cord-022313-2675sjlf	473	10	,	,	,
cord-022313-2675sjlf	473	11	and	and	CC
cord-022313-2675sjlf	473	12	the	the	DT
cord-022313-2675sjlf	473	13	oligosaccharide	oligosaccharide	JJ
cord-022313-2675sjlf	473	14	structure	structure	NN
cord-022313-2675sjlf	473	15	of	of	IN
cord-022313-2675sjlf	473	16	the	the	DT
cord-022313-2675sjlf	473	17	transferrin	transferrin	NN
cord-022313-2675sjlf	473	18	receptor	receptor	NN
cord-022313-2675sjlf	473	19	was	be	VBD
cord-022313-2675sjlf	473	20	determined	determine	VBN
cord-022313-2675sjlf	473	21	at	at	IN
cord-022313-2675sjlf	473	22	various	various	JJ
cord-022313-2675sjlf	473	23	times	time	NNS
cord-022313-2675sjlf	473	24	and	and	CC
cord-022313-2675sjlf	473	25	in	in	IN
cord-022313-2675sjlf	473	26	conditions	condition	NNS
cord-022313-2675sjlf	473	27	under	under	IN
cord-022313-2675sjlf	473	28	which	which	WDT
cord-022313-2675sjlf	473	29	this	this	DT
cord-022313-2675sjlf	473	30	receptor	receptor	NN
cord-022313-2675sjlf	473	31	would	would	MD
cord-022313-2675sjlf	473	32	be	be	VB
cord-022313-2675sjlf	473	33	endocytosed	endocytose	VBN
cord-022313-2675sjlf	473	34	.	.	.
cord-022313-2675sjlf	474	1	The	the	DT
cord-022313-2675sjlf	474	2	initial	initial	JJ
cord-022313-2675sjlf	474	3	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	474	4	of	of	IN
cord-022313-2675sjlf	474	5	the	the	DT
cord-022313-2675sjlf	474	6	trans	trans	NNP
cord-022313-2675sjlf	474	7	ferrin	ferrin	NNP
cord-022313-2675sjlf	474	8	receptor	receptor	NN
cord-022313-2675sjlf	474	9	were	be	VBD
cord-022313-2675sjlf	474	10	high	high	JJ
cord-022313-2675sjlf	474	11	-	-	HYPH
cord-022313-2675sjlf	474	12	mannose	mannose	NN
cord-022313-2675sjlf	474	13	structures	structure	NNS
cord-022313-2675sjlf	474	14	because	because	IN
cord-022313-2675sjlf	474	15	of	of	IN
cord-022313-2675sjlf	474	16	the	the	DT
cord-022313-2675sjlf	474	17	presence	presence	NN
cord-022313-2675sjlf	474	18	of	of	IN
cord-022313-2675sjlf	474	19	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	474	20	during	during	IN
cord-022313-2675sjlf	474	21	their	-PRON-	PRP$
cord-022313-2675sjlf	474	22	synthesis	synthesis	NN
cord-022313-2675sjlf	474	23	,	,	,
cord-022313-2675sjlf	474	24	but	but	CC
cord-022313-2675sjlf	474	25	during	during	IN
cord-022313-2675sjlf	474	26	the	the	DT
cord-022313-2675sjlf	474	27	chase	chase	NN
cord-022313-2675sjlf	474	28	,	,	,
cord-022313-2675sjlf	474	29	a	a	DT
cord-022313-2675sjlf	474	30	small	small	JJ
cord-022313-2675sjlf	474	31	percentage	percentage	NN
cord-022313-2675sjlf	474	32	of	of	IN
cord-022313-2675sjlf	474	33	the	the	DT
cord-022313-2675sjlf	474	34	recycled	recycle	VBN
cord-022313-2675sjlf	474	35	receptor	receptor	NN
cord-022313-2675sjlf	474	36	underwent	undergo	VBD
cord-022313-2675sjlf	474	37	processing	processing	NN
cord-022313-2675sjlf	474	38	and	and	CC
cord-022313-2675sjlf	474	39	attained	attain	VBD
cord-022313-2675sjlf	474	40	complex	complex	JJ
cord-022313-2675sjlf	474	41	types	type	NNS
cord-022313-2675sjlf	474	42	of	of	IN
cord-022313-2675sjlf	474	43	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	474	44	structures	structure	NNS
cord-022313-2675sjlf	474	45	,	,	,
cord-022313-2675sjlf	474	46	indicating	indicate	VBG
cord-022313-2675sjlf	474	47	that	that	IN
cord-022313-2675sjlf	474	48	some	some	DT
cord-022313-2675sjlf	474	49	of	of	IN
cord-022313-2675sjlf	474	50	the	the	DT
cord-022313-2675sjlf	474	51	endocytosed	endocytosed	JJ
cord-022313-2675sjlf	474	52	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	474	53	was	be	VBD
cord-022313-2675sjlf	474	54	recycled	recycle	VBN
cord-022313-2675sjlf	474	55	through	through	IN
cord-022313-2675sjlf	474	56	the	the	DT
cord-022313-2675sjlf	474	57	cis	cis	NNP
cord-022313-2675sjlf	474	58	-	-	HYPH
cord-022313-2675sjlf	474	59	Golgi	Golgi	NNP
cord-022313-2675sjlf	474	60	compartments	compartment	NNS
cord-022313-2675sjlf	474	61	(	(	-LRB-
cord-022313-2675sjlf	474	62	193	193	CD
cord-022313-2675sjlf	474	63	)	)	-RRB-
cord-022313-2675sjlf	474	64	.	.	.
cord-022313-2675sjlf	475	1	However	however	RB
cord-022313-2675sjlf	475	2	,	,	,
cord-022313-2675sjlf	475	3	the	the	DT
cord-022313-2675sjlf	475	4	amount	amount	NN
cord-022313-2675sjlf	475	5	of	of	IN
cord-022313-2675sjlf	475	6	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	475	7	that	that	WDT
cord-022313-2675sjlf	475	8	actually	actually	RB
cord-022313-2675sjlf	475	9	underwent	undergo	VBD
cord-022313-2675sjlf	475	10	modification	modification	NN
cord-022313-2675sjlf	475	11	during	during	IN
cord-022313-2675sjlf	475	12	the	the	DT
cord-022313-2675sjlf	475	13	recycling	recycling	NN
cord-022313-2675sjlf	475	14	was	be	VBD
cord-022313-2675sjlf	475	15	quite	quite	RB
cord-022313-2675sjlf	475	16	small	small	JJ
cord-022313-2675sjlf	475	17	,	,	,
cord-022313-2675sjlf	475	18	indicating	indicate	VBG
cord-022313-2675sjlf	475	19	that	that	IN
cord-022313-2675sjlf	475	20	,	,	,
cord-022313-2675sjlf	475	21	while	while	IN
cord-022313-2675sjlf	475	22	some	some	DT
cord-022313-2675sjlf	475	23	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	475	24	does	do	VBZ
cord-022313-2675sjlf	475	25	recycle	recycle	VB
cord-022313-2675sjlf	475	26	through	through	IN
cord-022313-2675sjlf	475	27	the	the	DT
cord-022313-2675sjlf	475	28	Golgi	Golgi	NNP
cord-022313-2675sjlf	475	29	,	,	,
cord-022313-2675sjlf	475	30	this	this	DT
cord-022313-2675sjlf	475	31	is	be	VBZ
cord-022313-2675sjlf	475	32	probably	probably	RB
cord-022313-2675sjlf	475	33	not	not	RB
cord-022313-2675sjlf	475	34	a	a	DT
cord-022313-2675sjlf	475	35	major	major	JJ
cord-022313-2675sjlf	475	36	route	route	NN
cord-022313-2675sjlf	475	37	.	.	.
cord-022313-2675sjlf	476	1	The	the	DT
cord-022313-2675sjlf	476	2	role	role	NN
cord-022313-2675sjlf	476	3	of	of	IN
cord-022313-2675sjlf	476	4	endoplasmic	endoplasmic	NN
cord-022313-2675sjlf	476	5	reticulum	reticulum	NN
cord-022313-2675sjlf	476	6	α	α	NNP
cord-022313-2675sjlf	476	7	-	-	HYPH
cord-022313-2675sjlf	476	8	mannosidase	mannosidase	NN
cord-022313-2675sjlf	476	9	was	be	VBD
cord-022313-2675sjlf	476	10	also	also	RB
cord-022313-2675sjlf	476	11	examined	examine	VBN
cord-022313-2675sjlf	476	12	in	in	IN
cord-022313-2675sjlf	476	13	UT-1	UT-1	NNP
cord-022313-2675sjlf	476	14	cells	cell	NNS
cord-022313-2675sjlf	476	15	,	,	,
cord-022313-2675sjlf	476	16	a	a	DT
cord-022313-2675sjlf	476	17	cell	cell	NN
cord-022313-2675sjlf	476	18	line	line	NN
cord-022313-2675sjlf	476	19	that	that	WDT
cord-022313-2675sjlf	476	20	overexpresses	overexpresse	VBZ
cord-022313-2675sjlf	476	21	HMG	HMG	NNP
cord-022313-2675sjlf	476	22	CoA	coa	NN
cord-022313-2675sjlf	476	23	reductase	reductase	NN
cord-022313-2675sjlf	476	24	.	.	.
cord-022313-2675sjlf	477	1	The	the	DT
cord-022313-2675sjlf	477	2	HMG	HMG	NNP
cord-022313-2675sjlf	477	3	CoA	coa	NN
cord-022313-2675sjlf	477	4	reductase	reductase	NN
cord-022313-2675sjlf	477	5	resides	reside	VBZ
cord-022313-2675sjlf	477	6	in	in	IN
cord-022313-2675sjlf	477	7	the	the	DT
cord-022313-2675sjlf	477	8	ER	er	NN
cord-022313-2675sjlf	477	9	of	of	IN
cord-022313-2675sjlf	477	10	cells	cell	NNS
cord-022313-2675sjlf	477	11	and	and	CC
cord-022313-2675sjlf	477	12	is	be	VBZ
cord-022313-2675sjlf	477	13	a	a	DT
cord-022313-2675sjlf	477	14	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	477	15	that	that	WDT
cord-022313-2675sjlf	477	16	has	have	VBZ
cord-022313-2675sjlf	477	17	high	high	JJ
cord-022313-2675sjlf	477	18	mannose	mannose	NN
cord-022313-2675sjlf	477	19	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	477	20	mostly	mostly	RB
cord-022313-2675sjlf	477	21	of	of	IN
cord-022313-2675sjlf	477	22	the	the	DT
cord-022313-2675sjlf	477	23	Man	Man	NNP
cord-022313-2675sjlf	477	24	8	8	CD
cord-022313-2675sjlf	477	25	(	(	-LRB-
cord-022313-2675sjlf	477	26	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	477	27	)	)	-RRB-
cord-022313-2675sjlf	477	28	2	2	CD
cord-022313-2675sjlf	477	29	and	and	CC
cord-022313-2675sjlf	477	30	Man	Man	NNP
cord-022313-2675sjlf	477	31	6	6	CD
cord-022313-2675sjlf	477	32	(	(	-LRB-
cord-022313-2675sjlf	477	33	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	477	34	)	)	-RRB-
cord-022313-2675sjlf	477	35	2	2	CD
cord-022313-2675sjlf	477	36	structures	structure	NNS
cord-022313-2675sjlf	477	37	.	.	.
cord-022313-2675sjlf	478	1	Previous	previous	JJ
cord-022313-2675sjlf	478	2	studies	study	NNS
cord-022313-2675sjlf	478	3	indicated	indicate	VBD
cord-022313-2675sjlf	478	4	that	that	IN
cord-022313-2675sjlf	478	5	"	"	``
cord-022313-2675sjlf	478	6	ER	ER	NNP
cord-022313-2675sjlf	478	7	"	"	''
cord-022313-2675sjlf	478	8	α	α	NN
cord-022313-2675sjlf	478	9	-	-	HYPH
cord-022313-2675sjlf	478	10	mannosidase	mannosidase	NN
cord-022313-2675sjlf	478	11	was	be	VBD
cord-022313-2675sjlf	478	12	not	not	RB
cord-022313-2675sjlf	478	13	inhibited	inhibit	VBN
cord-022313-2675sjlf	478	14	by	by	IN
cord-022313-2675sjlf	478	15	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	478	16	.	.	.
cord-022313-2675sjlf	479	1	Thus	thus	RB
cord-022313-2675sjlf	479	2	,	,	,
cord-022313-2675sjlf	479	3	in	in	IN
cord-022313-2675sjlf	479	4	the	the	DT
cord-022313-2675sjlf	479	5	presence	presence	NN
cord-022313-2675sjlf	479	6	of	of	IN
cord-022313-2675sjlf	479	7	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	479	8	,	,	,
cord-022313-2675sjlf	479	9	the	the	DT
cord-022313-2675sjlf	479	10	initial	initial	JJ
cord-022313-2675sjlf	479	11	trimming	trimming	NN
cord-022313-2675sjlf	479	12	of	of	IN
cord-022313-2675sjlf	479	13	the	the	DT
cord-022313-2675sjlf	479	14	oligo	oligo	NN
cord-022313-2675sjlf	479	15	saccharide	saccharide	NN
cord-022313-2675sjlf	479	16	chains	chain	NNS
cord-022313-2675sjlf	479	17	of	of	IN
cord-022313-2675sjlf	479	18	the	the	DT
cord-022313-2675sjlf	479	19	reductase	reductase	NN
cord-022313-2675sjlf	479	20	still	still	RB
cord-022313-2675sjlf	479	21	occurred	occur	VBD
cord-022313-2675sjlf	479	22	,	,	,
cord-022313-2675sjlf	479	23	but	but	CC
cord-022313-2675sjlf	479	24	in	in	IN
cord-022313-2675sjlf	479	25	this	this	DT
cord-022313-2675sjlf	479	26	case	case	NN
cord-022313-2675sjlf	479	27	,	,	,
cord-022313-2675sjlf	479	28	the	the	DT
cord-022313-2675sjlf	479	29	major	major	JJ
cord-022313-2675sjlf	479	30	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	479	31	structure	structure	NN
cord-022313-2675sjlf	479	32	on	on	IN
cord-022313-2675sjlf	479	33	the	the	DT
cord-022313-2675sjlf	479	34	protein	protein	NN
cord-022313-2675sjlf	479	35	was	be	VBD
cord-022313-2675sjlf	479	36	a	a	DT
cord-022313-2675sjlf	479	37	Man	man	NN
cord-022313-2675sjlf	479	38	8	8	CD
cord-022313-2675sjlf	479	39	(	(	-LRB-
cord-022313-2675sjlf	479	40	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	479	41	)	)	-RRB-
cord-022313-2675sjlf	479	42	2	2	CD
cord-022313-2675sjlf	479	43	and	and	CC
cord-022313-2675sjlf	479	44	the	the	DT
cord-022313-2675sjlf	479	45	smaller	small	JJR
cord-022313-2675sjlf	479	46	sized	sized	JJ
cord-022313-2675sjlf	479	47	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	479	48	were	be	VBD
cord-022313-2675sjlf	479	49	not	not	RB
cord-022313-2675sjlf	479	50	detected	detect	VBN
cord-022313-2675sjlf	479	51	.	.	.
cord-022313-2675sjlf	480	1	These	these	DT
cord-022313-2675sjlf	480	2	studies	study	NNS
cord-022313-2675sjlf	480	3	indicated	indicate	VBD
cord-022313-2675sjlf	480	4	that	that	IN
cord-022313-2675sjlf	480	5	the	the	DT
cord-022313-2675sjlf	480	6	ER	ER	NNP
cord-022313-2675sjlf	480	7	α	α	NNP
cord-022313-2675sjlf	480	8	-	-	HYPH
cord-022313-2675sjlf	480	9	mannosidase	mannosidase	NNP
cord-022313-2675sjlf	480	10	was	be	VBD
cord-022313-2675sjlf	480	11	involved	involve	VBN
cord-022313-2675sjlf	480	12	in	in	IN
cord-022313-2675sjlf	480	13	the	the	DT
cord-022313-2675sjlf	480	14	removal	removal	NN
cord-022313-2675sjlf	480	15	of	of	IN
cord-022313-2675sjlf	480	16	the	the	DT
cord-022313-2675sjlf	480	17	first	first	JJ
cord-022313-2675sjlf	480	18	mannose	mannose	NN
cord-022313-2675sjlf	480	19	,	,	,
cord-022313-2675sjlf	480	20	but	but	CC
cord-022313-2675sjlf	480	21	that	that	IN
cord-022313-2675sjlf	480	22	other	other	JJ
cord-022313-2675sjlf	480	23	α	α	NN
cord-022313-2675sjlf	480	24	-	-	HYPH
cord-022313-2675sjlf	480	25	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	480	26	were	be	VBD
cord-022313-2675sjlf	480	27	necessary	necessary	JJ
cord-022313-2675sjlf	480	28	for	for	IN
cord-022313-2675sjlf	480	29	the	the	DT
cord-022313-2675sjlf	480	30	removal	removal	NN
cord-022313-2675sjlf	480	31	of	of	IN
cord-022313-2675sjlf	480	32	other	other	JJ
cord-022313-2675sjlf	480	33	mannose	mannose	NN
cord-022313-2675sjlf	480	34	residues	residue	NNS
cord-022313-2675sjlf	480	35	(	(	-LRB-
cord-022313-2675sjlf	480	36	194	194	CD
cord-022313-2675sjlf	480	37	)	)	-RRB-
cord-022313-2675sjlf	480	38	.	.	.
cord-022313-2675sjlf	481	1	Another	another	DT
cord-022313-2675sjlf	481	2	mannosidase	mannosidase	NN
cord-022313-2675sjlf	481	3	inhibitor	inhibitor	NN
cord-022313-2675sjlf	481	4	is	be	VBZ
cord-022313-2675sjlf	481	5	l,4-dideoxy	l,4-dideoxy	JJ
cord-022313-2675sjlf	481	6	-	-	HYPH
cord-022313-2675sjlf	481	7	l,4-imino	l,4-imino	NNP
cord-022313-2675sjlf	481	8	-	-	HYPH
cord-022313-2675sjlf	481	9	D	d	NN
cord-022313-2675sjlf	481	10	-	-	HYPH
cord-022313-2675sjlf	481	11	mannitol	mannitol	NN
cord-022313-2675sjlf	481	12	(	(	-LRB-
cord-022313-2675sjlf	481	13	DIM	DIM	NNP
cord-022313-2675sjlf	481	14	)	)	-RRB-
cord-022313-2675sjlf	481	15	.	.	.
cord-022313-2675sjlf	482	1	This	this	DT
cord-022313-2675sjlf	482	2	inhibitor	inhibitor	NN
cord-022313-2675sjlf	482	3	has	have	VBZ
cord-022313-2675sjlf	482	4	a	a	DT
cord-022313-2675sjlf	482	5	furanose	furanose	JJ
cord-022313-2675sjlf	482	6	ring	ring	NN
cord-022313-2675sjlf	482	7	structure	structure	NN
cord-022313-2675sjlf	482	8	rather	rather	RB
cord-022313-2675sjlf	482	9	than	than	IN
cord-022313-2675sjlf	482	10	the	the	DT
cord-022313-2675sjlf	482	11	pyranose	pyranose	JJ
cord-022313-2675sjlf	482	12	rings	ring	NNS
cord-022313-2675sjlf	482	13	of	of	IN
cord-022313-2675sjlf	482	14	most	most	JJS
cord-022313-2675sjlf	482	15	of	of	IN
cord-022313-2675sjlf	482	16	the	the	DT
cord-022313-2675sjlf	482	17	other	other	JJ
cord-022313-2675sjlf	482	18	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	482	19	.	.	.
cord-022313-2675sjlf	483	1	DIM	DIM	NNP
cord-022313-2675sjlf	483	2	was	be	VBD
cord-022313-2675sjlf	483	3	synthesized	synthesize	VBN
cord-022313-2675sjlf	483	4	chemically	chemically	RB
cord-022313-2675sjlf	483	5	from	from	IN
cord-022313-2675sjlf	483	6	benzyl	benzyl	NN
cord-022313-2675sjlf	483	7	-	-	HYPH
cord-022313-2675sjlf	483	8	a	a	DT
cord-022313-2675sjlf	483	9	-	-	HYPH
cord-022313-2675sjlf	483	10	D	d	NN
cord-022313-2675sjlf	483	11	-	-	HYPH
cord-022313-2675sjlf	483	12	mannopyranose	mannopyranose	NN
cord-022313-2675sjlf	483	13	and	and	CC
cord-022313-2675sjlf	483	14	was	be	VBD
cord-022313-2675sjlf	483	15	found	find	VBN
cord-022313-2675sjlf	483	16	to	to	TO
cord-022313-2675sjlf	483	17	be	be	VB
cord-022313-2675sjlf	483	18	a	a	DT
cord-022313-2675sjlf	483	19	good	good	JJ
cord-022313-2675sjlf	483	20	inhibitor	inhibitor	NN
cord-022313-2675sjlf	483	21	of	of	IN
cord-022313-2675sjlf	483	22	jack	jack	NNP
cord-022313-2675sjlf	483	23	bean	bean	NNP
cord-022313-2675sjlf	483	24	α	α	NNP
cord-022313-2675sjlf	483	25	-	-	HYPH
cord-022313-2675sjlf	483	26	mannosidase	mannosidase	NN
cord-022313-2675sjlf	483	27	(	(	-LRB-
cord-022313-2675sjlf	483	28	195	195	CD
cord-022313-2675sjlf	483	29	)	)	-RRB-
cord-022313-2675sjlf	483	30	.	.	.
cord-022313-2675sjlf	484	1	It	-PRON-	PRP
cord-022313-2675sjlf	484	2	also	also	RB
cord-022313-2675sjlf	484	3	inhibited	inhibit	VBD
cord-022313-2675sjlf	484	4	the	the	DT
cord-022313-2675sjlf	484	5	pro	pro	JJ
cord-022313-2675sjlf	484	6	cessing	cessing	NN
cord-022313-2675sjlf	484	7	of	of	IN
cord-022313-2675sjlf	484	8	N	n	NN
cord-022313-2675sjlf	484	9	-	-	HYPH
cord-022313-2675sjlf	484	10	linked	link	VBN
cord-022313-2675sjlf	484	11	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	484	12	in	in	IN
cord-022313-2675sjlf	484	13	cell	cell	NN
cord-022313-2675sjlf	484	14	culture	culture	NN
cord-022313-2675sjlf	484	15	when	when	WRB
cord-022313-2675sjlf	484	16	it	-PRON-	PRP
cord-022313-2675sjlf	484	17	was	be	VBD
cord-022313-2675sjlf	484	18	added	add	VBN
cord-022313-2675sjlf	484	19	to	to	IN
cord-022313-2675sjlf	484	20	the	the	DT
cord-022313-2675sjlf	484	21	culture	culture	NN
cord-022313-2675sjlf	484	22	medium	medium	NN
cord-022313-2675sjlf	484	23	of	of	IN
cord-022313-2675sjlf	484	24	MDCK	MDCK	NNP
cord-022313-2675sjlf	484	25	cells	cell	NNS
cord-022313-2675sjlf	484	26	.	.	.
cord-022313-2675sjlf	485	1	In	in	IN
cord-022313-2675sjlf	485	2	those	those	DT
cord-022313-2675sjlf	485	3	experiments	experiment	NNS
cord-022313-2675sjlf	485	4	,	,	,
cord-022313-2675sjlf	485	5	the	the	DT
cord-022313-2675sjlf	485	6	major	major	JJ
cord-022313-2675sjlf	485	7	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	485	8	formed	form	VBN
cord-022313-2675sjlf	485	9	on	on	IN
cord-022313-2675sjlf	485	10	the	the	DT
cord-022313-2675sjlf	485	11	cell	cell	NN
cord-022313-2675sjlf	485	12	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	485	13	were	be	VBD
cord-022313-2675sjlf	485	14	Man	man	NN
cord-022313-2675sjlf	485	15	9	9	CD
cord-022313-2675sjlf	485	16	(	(	-LRB-
cord-022313-2675sjlf	485	17	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	485	18	)	)	-RRB-
cord-022313-2675sjlf	485	19	2	2	CD
cord-022313-2675sjlf	485	20	structures	structure	NNS
cord-022313-2675sjlf	485	21	in	in	IN
cord-022313-2675sjlf	485	22	keeping	keep	VBG
cord-022313-2675sjlf	485	23	with	with	IN
cord-022313-2675sjlf	485	24	the	the	DT
cord-022313-2675sjlf	485	25	hypothesis	hypothesis	NN
cord-022313-2675sjlf	485	26	that	that	WDT
cord-022313-2675sjlf	485	27	DIM	dim	VBP
cord-022313-2675sjlf	485	28	inhibited	inhibit	VBD
cord-022313-2675sjlf	485	29	the	the	DT
cord-022313-2675sjlf	485	30	Golgi	Golgi	NNP
cord-022313-2675sjlf	485	31	mannosidase	mannosidase	NN
cord-022313-2675sjlf	486	1	I	-PRON-	PRP
cord-022313-2675sjlf	486	2	(	(	-LRB-
cord-022313-2675sjlf	486	3	196	196	CD
cord-022313-2675sjlf	486	4	)	)	-RRB-
cord-022313-2675sjlf	486	5	.	.	.
cord-022313-2675sjlf	487	1	However	however	RB
cord-022313-2675sjlf	487	2	,	,	,
cord-022313-2675sjlf	487	3	it	-PRON-	PRP
cord-022313-2675sjlf	487	4	is	be	VBZ
cord-022313-2675sjlf	487	5	not	not	RB
cord-022313-2675sjlf	487	6	known	know	VBN
cord-022313-2675sjlf	487	7	whether	whether	IN
cord-022313-2675sjlf	487	8	DIM	dim	NN
cord-022313-2675sjlf	488	1	also	also	RB
cord-022313-2675sjlf	488	2	inhib	inhib	NNP
cord-022313-2675sjlf	488	3	its	-PRON-	PRP$
cord-022313-2675sjlf	488	4	the	the	DT
cord-022313-2675sjlf	488	5	ER	ER	NNP
cord-022313-2675sjlf	488	6	mannosidase	mannosidase	NN
cord-022313-2675sjlf	488	7	,	,	,
cord-022313-2675sjlf	488	8	because	because	IN
cord-022313-2675sjlf	488	9	this	this	DT
cord-022313-2675sjlf	488	10	activity	activity	NN
cord-022313-2675sjlf	488	11	does	do	VBZ
cord-022313-2675sjlf	488	12	not	not	RB
cord-022313-2675sjlf	488	13	appear	appear	VB
cord-022313-2675sjlf	488	14	to	to	TO
cord-022313-2675sjlf	488	15	be	be	VB
cord-022313-2675sjlf	488	16	present	present	JJ
cord-022313-2675sjlf	488	17	in	in	IN
cord-022313-2675sjlf	488	18	MDCK	MDCK	NNP
cord-022313-2675sjlf	488	19	cells	cell	NNS
cord-022313-2675sjlf	488	20	.	.	.
cord-022313-2675sjlf	489	1	Furthermore	furthermore	RB
cord-022313-2675sjlf	489	2	,	,	,
cord-022313-2675sjlf	489	3	there	there	EX
cord-022313-2675sjlf	489	4	is	be	VBZ
cord-022313-2675sjlf	489	5	no	no	DT
cord-022313-2675sjlf	489	6	indication	indication	NN
cord-022313-2675sjlf	489	7	that	that	IN
cord-022313-2675sjlf	489	8	this	this	DT
cord-022313-2675sjlf	489	9	inhibitor	inhibitor	NN
cord-022313-2675sjlf	489	10	has	have	VBZ
cord-022313-2675sjlf	489	11	been	be	VBN
cord-022313-2675sjlf	489	12	tested	test	VBN
cord-022313-2675sjlf	489	13	against	against	IN
cord-022313-2675sjlf	489	14	this	this	DT
cord-022313-2675sjlf	489	15	ER	ER	NNP
cord-022313-2675sjlf	489	16	mannosidase	mannosidase	NN
cord-022313-2675sjlf	489	17	or	or	CC
cord-022313-2675sjlf	489	18	other	other	JJ
cord-022313-2675sjlf	489	19	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	489	20	,	,	,
cord-022313-2675sjlf	489	21	although	although	IN
cord-022313-2675sjlf	489	22	it	-PRON-	PRP
cord-022313-2675sjlf	489	23	is	be	VBZ
cord-022313-2675sjlf	489	24	active	active	JJ
cord-022313-2675sjlf	489	25	against	against	IN
cord-022313-2675sjlf	489	26	mannosidase	mannosidase	NN
cord-022313-2675sjlf	490	1	I.	I.	NNP
cord-022313-2675sjlf	490	2	Thus	thus	RB
cord-022313-2675sjlf	490	3	,	,	,
cord-022313-2675sjlf	490	4	in	in	IN
cord-022313-2675sjlf	490	5	vitro	vitro	FW
cord-022313-2675sjlf	490	6	stud	stud	NN
cord-022313-2675sjlf	490	7	ies	ie	NNS
cord-022313-2675sjlf	490	8	with	with	IN
cord-022313-2675sjlf	490	9	DIM	dim	NN
cord-022313-2675sjlf	490	10	and	and	CC
cord-022313-2675sjlf	490	11	a	a	DT
cord-022313-2675sjlf	490	12	partially	partially	RB
cord-022313-2675sjlf	490	13	purified	purify	VBN
cord-022313-2675sjlf	490	14	preparation	preparation	NN
cord-022313-2675sjlf	490	15	of	of	IN
cord-022313-2675sjlf	490	16	mannosidase	mannosidase	NN
cord-022313-2675sjlf	490	17	I	-PRON-	PRP
cord-022313-2675sjlf	490	18	from	from	IN
cord-022313-2675sjlf	490	19	rat	rat	NN
cord-022313-2675sjlf	490	20	liver	liver	NN
cord-022313-2675sjlf	490	21	showed	show	VBD
cord-022313-2675sjlf	490	22	that	that	IN
cord-022313-2675sjlf	490	23	this	this	DT
cord-022313-2675sjlf	490	24	compound	compound	NN
cord-022313-2675sjlf	490	25	inhibits	inhibit	VBZ
cord-022313-2675sjlf	490	26	the	the	DT
cord-022313-2675sjlf	490	27	release	release	NN
cord-022313-2675sjlf	490	28	of	of	IN
cord-022313-2675sjlf	490	29	[	[	-LRB-
cord-022313-2675sjlf	490	30	3	3	CD
cord-022313-2675sjlf	490	31	H]mannose	H]mannose	NNP
cord-022313-2675sjlf	490	32	from	from	IN
cord-022313-2675sjlf	490	33	[	[	-LRB-
cord-022313-2675sjlf	490	34	3	3	CD
cord-022313-2675sjlf	490	35	H]mannose	H]mannose	NNP
cord-022313-2675sjlf	490	36	-	-	HYPH
cord-022313-2675sjlf	490	37	labeled	label	VBN
cord-022313-2675sjlf	490	38	Man	Man	NNP
cord-022313-2675sjlf	490	39	9	9	CD
cord-022313-2675sjlf	490	40	GlcNAc	glcnac	NN
cord-022313-2675sjlf	490	41	.	.	.
cord-022313-2675sjlf	491	1	DIM	DIM	NNP
cord-022313-2675sjlf	491	2	is	be	VBZ
cord-022313-2675sjlf	491	3	not	not	RB
cord-022313-2675sjlf	491	4	nearly	nearly	RB
cord-022313-2675sjlf	491	5	as	as	RB
cord-022313-2675sjlf	491	6	effective	effective	JJ
cord-022313-2675sjlf	491	7	as	as	IN
cord-022313-2675sjlf	491	8	a	a	DT
cord-022313-2675sjlf	491	9	mannosidase	mannosidase	NN
cord-022313-2675sjlf	491	10	inhibitor	inhibitor	NN
cord-022313-2675sjlf	491	11	as	as	IN
cord-022313-2675sjlf	491	12	is	be	VBZ
cord-022313-2675sjlf	491	13	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	491	14	or	or	CC
cord-022313-2675sjlf	491	15	kifunensine	kifunensine	NNP
cord-022313-2675sjlf	491	16	.	.	.
cord-022313-2675sjlf	492	1	However	however	RB
cord-022313-2675sjlf	492	2	,	,	,
cord-022313-2675sjlf	492	3	it	-PRON-	PRP
cord-022313-2675sjlf	492	4	is	be	VBZ
cord-022313-2675sjlf	492	5	much	much	RB
cord-022313-2675sjlf	492	6	more	more	RBR
cord-022313-2675sjlf	492	7	readily	readily	RB
cord-022313-2675sjlf	492	8	available	available	JJ
cord-022313-2675sjlf	492	9	in	in	IN
cord-022313-2675sjlf	492	10	large	large	JJ
cord-022313-2675sjlf	492	11	amounts	amount	NNS
cord-022313-2675sjlf	492	12	because	because	IN
cord-022313-2675sjlf	492	13	the	the	DT
cord-022313-2675sjlf	492	14	chemical	chemical	JJ
cord-022313-2675sjlf	492	15	synthesis	synthesis	NN
cord-022313-2675sjlf	492	16	is	be	VBZ
cord-022313-2675sjlf	492	17	quite	quite	RB
cord-022313-2675sjlf	492	18	simple	simple	JJ
cord-022313-2675sjlf	492	19	.	.	.
cord-022313-2675sjlf	493	1	Therefore	therefore	RB
cord-022313-2675sjlf	493	2	,	,	,
cord-022313-2675sjlf	493	3	DIM	dim	NN
cord-022313-2675sjlf	493	4	and	and	CC
cord-022313-2675sjlf	493	5	its	-PRON-	PRP$
cord-022313-2675sjlf	493	6	isomers	isomer	NNS
cord-022313-2675sjlf	493	7	should	should	MD
cord-022313-2675sjlf	493	8	be	be	VB
cord-022313-2675sjlf	493	9	valuable	valuable	JJ
cord-022313-2675sjlf	493	10	for	for	IN
cord-022313-2675sjlf	493	11	animal	animal	NN
cord-022313-2675sjlf	493	12	studies	study	NNS
cord-022313-2675sjlf	493	13	,	,	,
cord-022313-2675sjlf	493	14	as	as	RB
cord-022313-2675sjlf	493	15	well	well	RB
cord-022313-2675sjlf	493	16	as	as	IN
cord-022313-2675sjlf	493	17	for	for	IN
cord-022313-2675sjlf	493	18	other	other	JJ
cord-022313-2675sjlf	493	19	experiments	experiment	NNS
cord-022313-2675sjlf	493	20	requiring	require	VBG
cord-022313-2675sjlf	493	21	large	large	JJ
cord-022313-2675sjlf	493	22	amounts	amount	NNS
cord-022313-2675sjlf	493	23	of	of	IN
cord-022313-2675sjlf	493	24	mannosidase	mannosidase	NN
cord-022313-2675sjlf	493	25	inhibitor	inhibitor	NN
cord-022313-2675sjlf	493	26	.	.	.
cord-022313-2675sjlf	494	1	Kifunensine	Kifunensine	NNP
cord-022313-2675sjlf	494	2	is	be	VBZ
cord-022313-2675sjlf	494	3	an	an	DT
cord-022313-2675sjlf	494	4	alkaloid	alkaloid	NN
cord-022313-2675sjlf	494	5	,	,	,
cord-022313-2675sjlf	494	6	produced	produce	VBN
cord-022313-2675sjlf	494	7	by	by	IN
cord-022313-2675sjlf	494	8	the	the	DT
cord-022313-2675sjlf	494	9	actinomycete	actinomycete	NN
cord-022313-2675sjlf	494	10	Kitasatosporia	Kitasatosporia	NNP
cord-022313-2675sjlf	494	11	kifunense	kifunense	NN
cord-022313-2675sjlf	494	12	and	and	CC
cord-022313-2675sjlf	494	13	corresponding	correspond	VBG
cord-022313-2675sjlf	494	14	in	in	IN
cord-022313-2675sjlf	494	15	structure	structure	NN
cord-022313-2675sjlf	494	16	to	to	IN
cord-022313-2675sjlf	494	17	the	the	DT
cord-022313-2675sjlf	494	18	cyclic	cyclic	JJ
cord-022313-2675sjlf	494	19	oxamide	oxamide	NN
cord-022313-2675sjlf	494	20	derivative	derivative	NN
cord-022313-2675sjlf	494	21	of	of	IN
cord-022313-2675sjlf	494	22	1-aminodeoxymannojirimycin	1-aminodeoxymannojirimycin	CD
cord-022313-2675sjlf	494	23	(	(	-LRB-
cord-022313-2675sjlf	494	24	197	197	CD
cord-022313-2675sjlf	494	25	)	)	-RRB-
cord-022313-2675sjlf	494	26	.	.	.
cord-022313-2675sjlf	495	1	Kifunensine	Kifunensine	NNP
cord-022313-2675sjlf	495	2	is	be	VBZ
cord-022313-2675sjlf	495	3	a	a	DT
cord-022313-2675sjlf	495	4	very	very	RB
cord-022313-2675sjlf	495	5	weak	weak	JJ
cord-022313-2675sjlf	495	6	inhibitor	inhibitor	NN
cord-022313-2675sjlf	495	7	of	of	IN
cord-022313-2675sjlf	495	8	jack	jack	NNP
cord-022313-2675sjlf	495	9	bean	bean	NNP
cord-022313-2675sjlf	495	10	α	α	NNP
cord-022313-2675sjlf	495	11	-	-	HYPH
cord-022313-2675sjlf	495	12	mannosidase	mannosidase	NN
cord-022313-2675sjlf	495	13	(	(	-LRB-
cord-022313-2675sjlf	495	14	IC	IC	NNP
cord-022313-2675sjlf	495	15	50	50	CD
cord-022313-2675sjlf	495	16	=	=	SYM
cord-022313-2675sjlf	495	17	1.2	1.2	CD
cord-022313-2675sjlf	495	18	χ	χ	CD
cord-022313-2675sjlf	495	19	10	10	CD
cord-022313-2675sjlf	495	20	"	"	``
cord-022313-2675sjlf	495	21	4	4	CD
cord-022313-2675sjlf	495	22	M	M	NNP
cord-022313-2675sjlf	495	23	)	)	-RRB-
cord-022313-2675sjlf	495	24	,	,	,
cord-022313-2675sjlf	495	25	but	but	CC
cord-022313-2675sjlf	495	26	it	-PRON-	PRP
cord-022313-2675sjlf	495	27	is	be	VBZ
cord-022313-2675sjlf	495	28	a	a	DT
cord-022313-2675sjlf	495	29	potent	potent	JJ
cord-022313-2675sjlf	495	30	inhibitor	inhibitor	NN
cord-022313-2675sjlf	495	31	of	of	IN
cord-022313-2675sjlf	495	32	the	the	DT
cord-022313-2675sjlf	495	33	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	495	34	processing	processing	NN
cord-022313-2675sjlf	495	35	mannosidase	mannosidase	NN
cord-022313-2675sjlf	495	36	I	I	NNP
cord-022313-2675sjlf	495	37	(	(	-LRB-
cord-022313-2675sjlf	495	38	IC	IC	NNP
cord-022313-2675sjlf	495	39	50	50	CD
cord-022313-2675sjlf	495	40	=	=	SYM
cord-022313-2675sjlf	495	41	2	2	CD
cord-022313-2675sjlf	495	42	-	-	SYM
cord-022313-2675sjlf	495	43	5	5	CD
cord-022313-2675sjlf	495	44	χ	χ	CD
cord-022313-2675sjlf	495	45	10	10	CD
cord-022313-2675sjlf	495	46	"	"	``
cord-022313-2675sjlf	495	47	8	8	CD
cord-022313-2675sjlf	495	48	M	M	NNP
cord-022313-2675sjlf	495	49	)	)	-RRB-
cord-022313-2675sjlf	495	50	.	.	.
cord-022313-2675sjlf	496	1	Thus	thus	RB
cord-022313-2675sjlf	496	2	,	,	,
cord-022313-2675sjlf	496	3	this	this	DT
cord-022313-2675sjlf	496	4	inhibitor	inhibitor	NN
cord-022313-2675sjlf	496	5	is	be	VBZ
cord-022313-2675sjlf	496	6	about	about	RB
cord-022313-2675sjlf	496	7	100	100	CD
cord-022313-2675sjlf	496	8	times	time	NNS
cord-022313-2675sjlf	496	9	more	more	RBR
cord-022313-2675sjlf	496	10	effective	effective	JJ
cord-022313-2675sjlf	496	11	against	against	IN
cord-022313-2675sjlf	496	12	this	this	DT
cord-022313-2675sjlf	496	13	enzyme	enzyme	NN
cord-022313-2675sjlf	496	14	than	than	IN
cord-022313-2675sjlf	496	15	is	be	VBZ
cord-022313-2675sjlf	496	16	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	496	17	.	.	.
cord-022313-2675sjlf	497	1	On	on	IN
cord-022313-2675sjlf	497	2	the	the	DT
cord-022313-2675sjlf	497	3	other	other	JJ
cord-022313-2675sjlf	497	4	hand	hand	NN
cord-022313-2675sjlf	497	5	,	,	,
cord-022313-2675sjlf	497	6	kifunensine	kifunensine	NNP
cord-022313-2675sjlf	497	7	had	have	VBD
cord-022313-2675sjlf	497	8	no	no	DT
cord-022313-2675sjlf	497	9	effect	effect	NN
cord-022313-2675sjlf	497	10	on	on	IN
cord-022313-2675sjlf	497	11	mannosidase	mannosidase	NN
cord-022313-2675sjlf	498	1	I	-PRON-	PRP
cord-022313-2675sjlf	498	2	(	(	-LRB-
cord-022313-2675sjlf	498	3	198	198	CD
cord-022313-2675sjlf	498	4	)	)	-RRB-
cord-022313-2675sjlf	498	5	.	.	.
cord-022313-2675sjlf	499	1	Using	use	VBG
cord-022313-2675sjlf	499	2	rat	rat	NN
cord-022313-2675sjlf	499	3	liver	liver	NN
cord-022313-2675sjlf	499	4	microsomes	microsome	NNS
cord-022313-2675sjlf	499	5	as	as	IN
cord-022313-2675sjlf	499	6	a	a	DT
cord-022313-2675sjlf	499	7	source	source	NN
cord-022313-2675sjlf	499	8	of	of	IN
cord-022313-2675sjlf	499	9	mannosidase	mannosidase	NN
cord-022313-2675sjlf	499	10	activities	activity	NNS
cord-022313-2675sjlf	499	11	,	,	,
cord-022313-2675sjlf	499	12	kifunensine	kifunensine	NNP
cord-022313-2675sjlf	499	13	strongly	strongly	RB
cord-022313-2675sjlf	499	14	inhibited	inhibit	VBD
cord-022313-2675sjlf	499	15	the	the	DT
cord-022313-2675sjlf	499	16	Golgi	Golgi	NNP
cord-022313-2675sjlf	499	17	mannosidase	mannosidase	NN
cord-022313-2675sjlf	500	1	I	-PRON-	PRP
cord-022313-2675sjlf	501	1	but	but	CC
cord-022313-2675sjlf	501	2	it	-PRON-	PRP
cord-022313-2675sjlf	501	3	was	be	VBD
cord-022313-2675sjlf	501	4	probably	probably	RB
cord-022313-2675sjlf	501	5	without	without	IN
cord-022313-2675sjlf	501	6	effect	effect	NN
cord-022313-2675sjlf	501	7	on	on	IN
cord-022313-2675sjlf	501	8	the	the	DT
cord-022313-2675sjlf	501	9	proposed	propose	VBN
cord-022313-2675sjlf	501	10	ER	ER	NNP
cord-022313-2675sjlf	501	11	α	α	NNP
cord-022313-2675sjlf	501	12	-	-	HYPH
cord-022313-2675sjlf	501	13	mannosidase	mannosidase	NN
cord-022313-2675sjlf	501	14	.	.	.
cord-022313-2675sjlf	502	1	In	in	IN
cord-022313-2675sjlf	502	2	cell	cell	NN
cord-022313-2675sjlf	502	3	culture	culture	NN
cord-022313-2675sjlf	502	4	with	with	IN
cord-022313-2675sjlf	502	5	MDCK	MDCK	NNP
cord-022313-2675sjlf	502	6	cells	cell	NNS
cord-022313-2675sjlf	502	7	,	,	,
cord-022313-2675sjlf	502	8	kifunensine	kifunensine	NNP
cord-022313-2675sjlf	502	9	gave	give	VBD
cord-022313-2675sjlf	502	10	rise	rise	NN
cord-022313-2675sjlf	502	11	to	to	IN
cord-022313-2675sjlf	502	12	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	502	13	having	have	VBG
cord-022313-2675sjlf	502	14	Man	man	NN
cord-022313-2675sjlf	502	15	9	9	CD
cord-022313-2675sjlf	503	1	(	(	-LRB-
cord-022313-2675sjlf	503	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	503	3	)	)	-RRB-
cord-022313-2675sjlf	503	4	2	2	CD
cord-022313-2675sjlf	503	5	structures	structure	NNS
cord-022313-2675sjlf	503	6	just	just	RB
cord-022313-2675sjlf	503	7	as	as	IN
cord-022313-2675sjlf	503	8	did	do	VBD
cord-022313-2675sjlf	503	9	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	503	10	,	,	,
cord-022313-2675sjlf	503	11	but	but	CC
cord-022313-2675sjlf	503	12	the	the	DT
cord-022313-2675sjlf	503	13	amount	amount	NN
cord-022313-2675sjlf	503	14	of	of	IN
cord-022313-2675sjlf	503	15	kifunen	kifunen	NNP
cord-022313-2675sjlf	503	16	sine	sine	NN
cord-022313-2675sjlf	503	17	needed	need	VBN
cord-022313-2675sjlf	503	18	for	for	IN
cord-022313-2675sjlf	503	19	this	this	DT
cord-022313-2675sjlf	503	20	effect	effect	NN
cord-022313-2675sjlf	503	21	was	be	VBD
cord-022313-2675sjlf	503	22	only	only	RB
cord-022313-2675sjlf	503	23	about	about	RB
cord-022313-2675sjlf	503	24	one	one	CD
cord-022313-2675sjlf	503	25	-	-	HYPH
cord-022313-2675sjlf	503	26	fiftieth	fiftieth	NN
cord-022313-2675sjlf	503	27	as	as	RB
cord-022313-2675sjlf	503	28	much	much	JJ
cord-022313-2675sjlf	503	29	as	as	IN
cord-022313-2675sjlf	503	30	deoxy	deoxy	JJ
cord-022313-2675sjlf	503	31	mannojirimycin	mannojirimycin	NNS
cord-022313-2675sjlf	503	32	.	.	.
cord-022313-2675sjlf	504	1	Recently	recently	RB
cord-022313-2675sjlf	504	2	,	,	,
cord-022313-2675sjlf	504	3	a	a	DT
cord-022313-2675sjlf	504	4	broad	broad	JJ
cord-022313-2675sjlf	504	5	-	-	HYPH
cord-022313-2675sjlf	504	6	spectrum	spectrum	NN
cord-022313-2675sjlf	504	7	α	α	NN
cord-022313-2675sjlf	504	8	-	-	HYPH
cord-022313-2675sjlf	504	9	mannosidase	mannosidase	NN
cord-022313-2675sjlf	504	10	inhibitor	inhibitor	NN
cord-022313-2675sjlf	504	11	was	be	VBD
cord-022313-2675sjlf	504	12	synthesized	synthesize	VBN
cord-022313-2675sjlf	504	13	chemically	chemically	RB
cord-022313-2675sjlf	504	14	as	as	IN
cord-022313-2675sjlf	504	15	a	a	DT
cord-022313-2675sjlf	504	16	mimic	mimic	NN
cord-022313-2675sjlf	504	17	of	of	IN
cord-022313-2675sjlf	504	18	the	the	DT
cord-022313-2675sjlf	504	19	mannopyranosyl	mannopyranosyl	NNP
cord-022313-2675sjlf	504	20	cation	cation	NNP
cord-022313-2675sjlf	504	21	,	,	,
cord-022313-2675sjlf	504	22	which	which	WDT
cord-022313-2675sjlf	504	23	is	be	VBZ
cord-022313-2675sjlf	504	24	the	the	DT
cord-022313-2675sjlf	504	25	putative	putative	JJ
cord-022313-2675sjlf	504	26	intermediate	intermediate	NN
cord-022313-2675sjlf	504	27	in	in	IN
cord-022313-2675sjlf	504	28	the	the	DT
cord-022313-2675sjlf	504	29	hydrolysis	hydrolysis	NN
cord-022313-2675sjlf	504	30	of	of	IN
cord-022313-2675sjlf	504	31	mannopyranosides	mannopyranoside	NNS
cord-022313-2675sjlf	504	32	(	(	-LRB-
cord-022313-2675sjlf	504	33	199	199	CD
cord-022313-2675sjlf	504	34	)	)	-RRB-
cord-022313-2675sjlf	504	35	.	.	.
cord-022313-2675sjlf	505	1	This	this	DT
cord-022313-2675sjlf	505	2	compound	compound	NN
cord-022313-2675sjlf	505	3	,	,	,
cord-022313-2675sjlf	505	4	whose	whose	WP$
cord-022313-2675sjlf	505	5	structure	structure	NN
cord-022313-2675sjlf	505	6	is	be	VBZ
cord-022313-2675sjlf	505	7	shown	show	VBN
cord-022313-2675sjlf	505	8	in	in	IN
cord-022313-2675sjlf	505	9	Fig	Fig	NNP
cord-022313-2675sjlf	505	10	.	.	NNP
cord-022313-2675sjlf	505	11	10	10	CD
cord-022313-2675sjlf	505	12	,	,	,
cord-022313-2675sjlf	505	13	is	be	VBZ
cord-022313-2675sjlf	505	14	called	call	VBN
cord-022313-2675sjlf	505	15	mannonolactam	mannonolactam	NNP
cord-022313-2675sjlf	505	16	amidrazone	amidrazone	NNP
cord-022313-2675sjlf	505	17	.	.	.
cord-022313-2675sjlf	506	1	This	this	DT
cord-022313-2675sjlf	506	2	compound	compound	NN
cord-022313-2675sjlf	506	3	was	be	VBD
cord-022313-2675sjlf	506	4	found	find	VBN
cord-022313-2675sjlf	506	5	to	to	TO
cord-022313-2675sjlf	506	6	be	be	VB
cord-022313-2675sjlf	506	7	a	a	DT
cord-022313-2675sjlf	506	8	more	more	RBR
cord-022313-2675sjlf	506	9	general	general	JJ
cord-022313-2675sjlf	506	10	mannosidase	mannosidase	NN
cord-022313-2675sjlf	506	11	inhibitor	inhibitor	NN
cord-022313-2675sjlf	506	12	than	than	IN
cord-022313-2675sjlf	506	13	any	any	DT
cord-022313-2675sjlf	506	14	of	of	IN
cord-022313-2675sjlf	506	15	the	the	DT
cord-022313-2675sjlf	506	16	other	other	JJ
cord-022313-2675sjlf	506	17	currently	currently	RB
cord-022313-2675sjlf	506	18	known	know	VBN
cord-022313-2675sjlf	506	19	com	com	NN
cord-022313-2675sjlf	506	20	pounds	pound	NNS
cord-022313-2675sjlf	506	21	and	and	CC
cord-022313-2675sjlf	506	22	those	those	DT
cord-022313-2675sjlf	506	23	shown	show	VBN
cord-022313-2675sjlf	506	24	in	in	IN
cord-022313-2675sjlf	506	25	Fig	Fig	NNP
cord-022313-2675sjlf	506	26	.	.	.
cord-022313-2675sjlf	507	1	10	10	CD
cord-022313-2675sjlf	507	2	.	.	.
cord-022313-2675sjlf	508	1	Thus	thus	RB
cord-022313-2675sjlf	508	2	,	,	,
cord-022313-2675sjlf	508	3	the	the	DT
cord-022313-2675sjlf	508	4	amidrazone	amidrazone	NN
cord-022313-2675sjlf	508	5	not	not	RB
cord-022313-2675sjlf	508	6	only	only	RB
cord-022313-2675sjlf	508	7	inhibits	inhibit	VBZ
cord-022313-2675sjlf	508	8	the	the	DT
cord-022313-2675sjlf	508	9	Golgi	Golgi	NNP
cord-022313-2675sjlf	508	10	mannosidase	mannosidase	NN
cord-022313-2675sjlf	509	1	I	-PRON-	PRP
cord-022313-2675sjlf	509	2	(	(	-LRB-
cord-022313-2675sjlf	509	3	IC	IC	NNP
cord-022313-2675sjlf	509	4	50	50	CD
cord-022313-2675sjlf	509	5	=	=	SYM
cord-022313-2675sjlf	509	6	4	4	CD
cord-022313-2675sjlf	509	7	μΜ	μΜ	NNP
cord-022313-2675sjlf	509	8	)	)	-RRB-
cord-022313-2675sjlf	509	9	and	and	CC
cord-022313-2675sjlf	509	10	mannosidase	mannosidase	NNP
cord-022313-2675sjlf	509	11	II	II	NNP
cord-022313-2675sjlf	509	12	(	(	-LRB-
cord-022313-2675sjlf	509	13	IC	IC	NNP
cord-022313-2675sjlf	509	14	50	50	CD
cord-022313-2675sjlf	509	15	=	=	SYM
cord-022313-2675sjlf	509	16	90	90	CD
cord-022313-2675sjlf	509	17	-	-	SYM
cord-022313-2675sjlf	509	18	100	100	CD
cord-022313-2675sjlf	509	19	nM	nM	NNP
cord-022313-2675sjlf	509	20	)	)	-RRB-
cord-022313-2675sjlf	509	21	,	,	,
cord-022313-2675sjlf	509	22	but	but	CC
cord-022313-2675sjlf	509	23	also	also	RB
cord-022313-2675sjlf	509	24	is	be	VBZ
cord-022313-2675sjlf	509	25	the	the	DT
cord-022313-2675sjlf	509	26	first	first	JJ
cord-022313-2675sjlf	509	27	compound	compound	NN
cord-022313-2675sjlf	509	28	that	that	WDT
cord-022313-2675sjlf	509	29	has	have	VBZ
cord-022313-2675sjlf	509	30	been	be	VBN
cord-022313-2675sjlf	509	31	found	find	VBN
cord-022313-2675sjlf	509	32	to	to	TO
cord-022313-2675sjlf	509	33	be	be	VB
cord-022313-2675sjlf	509	34	a	a	DT
cord-022313-2675sjlf	509	35	potent	potent	JJ
cord-022313-2675sjlf	509	36	inhibitor	inhibitor	NN
cord-022313-2675sjlf	509	37	of	of	IN
cord-022313-2675sjlf	509	38	the	the	DT
cord-022313-2675sjlf	509	39	soluble	soluble	JJ
cord-022313-2675sjlf	509	40	or	or	CC
cord-022313-2675sjlf	509	41	ER	ER	NNP
cord-022313-2675sjlf	509	42	α	α	NN
cord-022313-2675sjlf	509	43	-	-	HYPH
cord-022313-2675sjlf	509	44	mannosidase	mannosidase	NN
cord-022313-2675sjlf	509	45	(	(	-LRB-
cord-022313-2675sjlf	509	46	IC	IC	NNP
cord-022313-2675sjlf	509	47	50	50	CD
cord-022313-2675sjlf	509	48	=	=	SYM
cord-022313-2675sjlf	509	49	1	1	CD
cord-022313-2675sjlf	509	50	μΜ	μΜ	NNP
cord-022313-2675sjlf	509	51	)	)	-RRB-
cord-022313-2675sjlf	509	52	.	.	.
cord-022313-2675sjlf	510	1	In	in	IN
cord-022313-2675sjlf	510	2	addition	addition	NN
cord-022313-2675sjlf	510	3	,	,	,
cord-022313-2675sjlf	510	4	the	the	DT
cord-022313-2675sjlf	510	5	amidrazone	amidrazone	NN
cord-022313-2675sjlf	510	6	also	also	RB
cord-022313-2675sjlf	510	7	inhibited	inhibit	VBD
cord-022313-2675sjlf	510	8	both	both	CC
cord-022313-2675sjlf	510	9	the	the	DT
cord-022313-2675sjlf	510	10	aryl	aryl	NN
cord-022313-2675sjlf	510	11	-	-	HYPH
cord-022313-2675sjlf	510	12	amannosidase	amannosidase	NN
cord-022313-2675sjlf	510	13	and	and	CC
cord-022313-2675sjlf	510	14	the	the	DT
cord-022313-2675sjlf	510	15	aryl-/3-mannosidase	aryl-/3-mannosidase	NN
cord-022313-2675sjlf	510	16	,	,	,
cord-022313-2675sjlf	510	17	although	although	IN
cord-022313-2675sjlf	510	18	it	-PRON-	PRP
cord-022313-2675sjlf	510	19	was	be	VBD
cord-022313-2675sjlf	510	20	much	much	RB
cord-022313-2675sjlf	510	21	more	more	RBR
cord-022313-2675sjlf	510	22	effective	effective	JJ
cord-022313-2675sjlf	510	23	on	on	IN
cord-022313-2675sjlf	510	24	the	the	DT
cord-022313-2675sjlf	510	25	enzyme	enzyme	NN
cord-022313-2675sjlf	510	26	recognizing	recognize	VBG
cord-022313-2675sjlf	510	27	the	the	DT
cord-022313-2675sjlf	510	28	α	α	NN
cord-022313-2675sjlf	510	29	-	-	HYPH
cord-022313-2675sjlf	510	30	linkage	linkage	NN
cord-022313-2675sjlf	510	31	(	(	-LRB-
cord-022313-2675sjlf	510	32	IC	IC	NNP
cord-022313-2675sjlf	510	33	50	50	CD
cord-022313-2675sjlf	510	34	=	=	SYM
cord-022313-2675sjlf	510	35	400	400	CD
cord-022313-2675sjlf	510	36	η	η	NN
cord-022313-2675sjlf	510	37	M	M	NNP
cord-022313-2675sjlf	510	38	for	for	IN
cord-022313-2675sjlf	510	39	jack	jack	NNP
cord-022313-2675sjlf	510	40	bean	bean	NNP
cord-022313-2675sjlf	510	41	α	α	NNP
cord-022313-2675sjlf	510	42	-	-	HYPH
cord-022313-2675sjlf	510	43	mannosidase	mannosidase	NN
cord-022313-2675sjlf	510	44	compared	compare	VBN
cord-022313-2675sjlf	510	45	with	with	IN
cord-022313-2675sjlf	510	46	150	150	CD
cord-022313-2675sjlf	510	47	μΜ	μμ	NN
cord-022313-2675sjlf	510	48	for	for	IN
cord-022313-2675sjlf	510	49	/^-mannosidase	/^-mannosidase	NNP
cord-022313-2675sjlf	510	50	)	)	-RRB-
cord-022313-2675sjlf	510	51	.	.	.
cord-022313-2675sjlf	511	1	In	in	IN
cord-022313-2675sjlf	511	2	cell	cell	NN
cord-022313-2675sjlf	511	3	culture	culture	NN
cord-022313-2675sjlf	511	4	studies	study	NNS
cord-022313-2675sjlf	511	5	,	,	,
cord-022313-2675sjlf	511	6	the	the	DT
cord-022313-2675sjlf	511	7	amidrazone	amidrazone	NN
cord-022313-2675sjlf	511	8	completely	completely	RB
cord-022313-2675sjlf	511	9	prevented	prevent	VBD
cord-022313-2675sjlf	511	10	the	the	DT
cord-022313-2675sjlf	511	11	forma	forma	NN
cord-022313-2675sjlf	511	12	tion	tion	NN
cord-022313-2675sjlf	511	13	of	of	IN
cord-022313-2675sjlf	511	14	complex	complex	JJ
cord-022313-2675sjlf	511	15	types	type	NNS
cord-022313-2675sjlf	511	16	of	of	IN
cord-022313-2675sjlf	511	17	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	511	18	and	and	CC
cord-022313-2675sjlf	511	19	instead	instead	RB
cord-022313-2675sjlf	511	20	caused	cause	VBD
cord-022313-2675sjlf	511	21	the	the	DT
cord-022313-2675sjlf	511	22	forma	forma	NN
cord-022313-2675sjlf	511	23	tion	tion	NN
cord-022313-2675sjlf	511	24	of	of	IN
cord-022313-2675sjlf	511	25	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	511	26	having	have	VBG
cord-022313-2675sjlf	511	27	Man	man	NN
cord-022313-2675sjlf	511	28	9	9	CD
cord-022313-2675sjlf	511	29	(	(	-LRB-
cord-022313-2675sjlf	511	30	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	511	31	)	)	-RRB-
cord-022313-2675sjlf	511	32	2	2	CD
cord-022313-2675sjlf	511	33	and	and	CC
cord-022313-2675sjlf	511	34	Man	Man	NNP
cord-022313-2675sjlf	511	35	8	8	CD
cord-022313-2675sjlf	511	36	(	(	-LRB-
cord-022313-2675sjlf	511	37	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	511	38	)	)	-RRB-
cord-022313-2675sjlf	511	39	2	2	CD
cord-022313-2675sjlf	511	40	structures	structure	NNS
cord-022313-2675sjlf	511	41	.	.	.
cord-022313-2675sjlf	512	1	It	-PRON-	PRP
cord-022313-2675sjlf	512	2	is	be	VBZ
cord-022313-2675sjlf	512	3	hypothesized	hypothesize	VBN
cord-022313-2675sjlf	512	4	that	that	IN
cord-022313-2675sjlf	512	5	the	the	DT
cord-022313-2675sjlf	512	6	reason	reason	NN
cord-022313-2675sjlf	512	7	that	that	IN
cord-022313-2675sjlf	512	8	this	this	DT
cord-022313-2675sjlf	512	9	compound	compound	NN
cord-022313-2675sjlf	512	10	is	be	VBZ
cord-022313-2675sjlf	512	11	so	so	RB
cord-022313-2675sjlf	512	12	effective	effective	JJ
cord-022313-2675sjlf	512	13	against	against	IN
cord-022313-2675sjlf	512	14	all	all	DT
cord-022313-2675sjlf	512	15	of	of	IN
cord-022313-2675sjlf	512	16	these	these	DT
cord-022313-2675sjlf	512	17	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	512	18	is	be	VBZ
cord-022313-2675sjlf	512	19	that	that	IN
cord-022313-2675sjlf	512	20	it	-PRON-	PRP
cord-022313-2675sjlf	512	21	is	be	VBZ
cord-022313-2675sjlf	512	22	the	the	DT
cord-022313-2675sjlf	512	23	first	first	JJ
cord-022313-2675sjlf	512	24	monosaccharide	monosaccharide	NN
cord-022313-2675sjlf	512	25	analog	analog	NN
cord-022313-2675sjlf	512	26	that	that	WDT
cord-022313-2675sjlf	512	27	mimics	mimic	VBZ
cord-022313-2675sjlf	512	28	the	the	DT
cord-022313-2675sjlf	512	29	true	true	JJ
cord-022313-2675sjlf	512	30	half	half	JJ
cord-022313-2675sjlf	512	31	-	-	HYPH
cord-022313-2675sjlf	512	32	chair	chair	NN
cord-022313-2675sjlf	512	33	conformation	conformation	NN
cord-022313-2675sjlf	512	34	of	of	IN
cord-022313-2675sjlf	512	35	the	the	DT
cord-022313-2675sjlf	512	36	cationic	cationic	JJ
cord-022313-2675sjlf	512	37	intermediate	intermediate	NN
cord-022313-2675sjlf	512	38	that	that	WDT
cord-022313-2675sjlf	512	39	is	be	VBZ
cord-022313-2675sjlf	512	40	believed	believe	VBN
cord-022313-2675sjlf	512	41	to	to	TO
cord-022313-2675sjlf	512	42	be	be	VB
cord-022313-2675sjlf	512	43	involved	involve	VBN
cord-022313-2675sjlf	512	44	in	in	IN
cord-022313-2675sjlf	512	45	the	the	DT
cord-022313-2675sjlf	512	46	cataly	cataly	NNP
cord-022313-2675sjlf	512	47	sis	sis	NN
cord-022313-2675sjlf	512	48	of	of	IN
cord-022313-2675sjlf	512	49	the	the	DT
cord-022313-2675sjlf	512	50	α	α	NN
cord-022313-2675sjlf	512	51	-	-	HYPH
cord-022313-2675sjlf	512	52	mannose	mannose	VBG
cord-022313-2675sjlf	512	53	glycosidic	glycosidic	NN
cord-022313-2675sjlf	512	54	bond	bond	NN
cord-022313-2675sjlf	512	55	.	.	.
cord-022313-2675sjlf	513	1	This	this	DT
cord-022313-2675sjlf	513	2	compound	compound	NN
cord-022313-2675sjlf	513	3	should	should	MD
cord-022313-2675sjlf	513	4	serve	serve	VB
cord-022313-2675sjlf	513	5	as	as	IN
cord-022313-2675sjlf	513	6	a	a	DT
cord-022313-2675sjlf	513	7	useful	useful	JJ
cord-022313-2675sjlf	513	8	model	model	NN
cord-022313-2675sjlf	513	9	to	to	TO
cord-022313-2675sjlf	513	10	synthesize	synthesize	VB
cord-022313-2675sjlf	513	11	other	other	JJ
cord-022313-2675sjlf	513	12	more	more	RBR
cord-022313-2675sjlf	513	13	specific	specific	JJ
cord-022313-2675sjlf	513	14	mannosidase	mannosidase	NN
cord-022313-2675sjlf	513	15	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	513	16	.	.	.
cord-022313-2675sjlf	514	1	As	as	IN
cord-022313-2675sjlf	514	2	indicated	indicate	VBN
cord-022313-2675sjlf	514	3	above	above	RB
cord-022313-2675sjlf	514	4	,	,	,
cord-022313-2675sjlf	514	5	the	the	DT
cord-022313-2675sjlf	514	6	first	first	JJ
cord-022313-2675sjlf	514	7	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	514	8	processing	processing	NN
cord-022313-2675sjlf	514	9	inhibitor	inhibitor	NN
cord-022313-2675sjlf	514	10	to	to	TO
cord-022313-2675sjlf	514	11	be	be	VB
cord-022313-2675sjlf	514	12	identified	identify	VBN
cord-022313-2675sjlf	514	13	was	be	VBD
cord-022313-2675sjlf	514	14	swainsonine	swainsonine	JJ
cord-022313-2675sjlf	514	15	.	.	.
cord-022313-2675sjlf	515	1	The	the	DT
cord-022313-2675sjlf	515	2	initial	initial	JJ
cord-022313-2675sjlf	515	3	interest	interest	NN
cord-022313-2675sjlf	515	4	in	in	IN
cord-022313-2675sjlf	515	5	this	this	DT
cord-022313-2675sjlf	515	6	compound	compound	NN
cord-022313-2675sjlf	515	7	was	be	VBD
cord-022313-2675sjlf	515	8	due	due	JJ
cord-022313-2675sjlf	515	9	to	to	IN
cord-022313-2675sjlf	515	10	the	the	DT
cord-022313-2675sjlf	515	11	fact	fact	NN
cord-022313-2675sjlf	515	12	that	that	IN
cord-022313-2675sjlf	515	13	it	-PRON-	PRP
cord-022313-2675sjlf	515	14	is	be	VBZ
cord-022313-2675sjlf	515	15	found	find	VBN
cord-022313-2675sjlf	515	16	in	in	IN
cord-022313-2675sjlf	515	17	plants	plant	NNS
cord-022313-2675sjlf	515	18	that	that	WDT
cord-022313-2675sjlf	515	19	are	be	VBP
cord-022313-2675sjlf	515	20	toxic	toxic	JJ
cord-022313-2675sjlf	515	21	to	to	IN
cord-022313-2675sjlf	515	22	grazing	graze	VBG
cord-022313-2675sjlf	515	23	animals	animal	NNS
cord-022313-2675sjlf	515	24	.	.	.
cord-022313-2675sjlf	516	1	In	in	IN
cord-022313-2675sjlf	516	2	Australia	Australia	NNP
cord-022313-2675sjlf	516	3	,	,	,
cord-022313-2675sjlf	516	4	the	the	DT
cord-022313-2675sjlf	516	5	major	major	JJ
cord-022313-2675sjlf	516	6	plant	plant	NN
cord-022313-2675sjlf	516	7	having	have	VBG
cord-022313-2675sjlf	516	8	this	this	DT
cord-022313-2675sjlf	516	9	alkaloid	alkaloid	NN
cord-022313-2675sjlf	516	10	is	be	VBZ
cord-022313-2675sjlf	516	11	called	call	VBN
cord-022313-2675sjlf	516	12	Swainsona	Swainsona	NNP
cord-022313-2675sjlf	516	13	canescens	canescen	NNS
cord-022313-2675sjlf	516	14	(	(	-LRB-
cord-022313-2675sjlf	516	15	200	200	CD
cord-022313-2675sjlf	516	16	)	)	-RRB-
cord-022313-2675sjlf	516	17	,	,	,
cord-022313-2675sjlf	516	18	while	while	IN
cord-022313-2675sjlf	516	19	in	in	IN
cord-022313-2675sjlf	516	20	the	the	DT
cord-022313-2675sjlf	516	21	United	United	NNP
cord-022313-2675sjlf	516	22	States	States	NNP
cord-022313-2675sjlf	516	23	,	,	,
cord-022313-2675sjlf	516	24	various	various	JJ
cord-022313-2675sjlf	516	25	plants	plant	NNS
cord-022313-2675sjlf	516	26	of	of	IN
cord-022313-2675sjlf	516	27	the	the	DT
cord-022313-2675sjlf	516	28	genus	genus	NN
cord-022313-2675sjlf	516	29	Astragalus	Astragalus	NNP
cord-022313-2675sjlf	516	30	contain	contain	VBP
cord-022313-2675sjlf	516	31	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	516	32	(	(	-LRB-
cord-022313-2675sjlf	516	33	201	201	CD
cord-022313-2675sjlf	516	34	,	,	,
cord-022313-2675sjlf	516	35	202	202	CD
cord-022313-2675sjlf	516	36	)	)	-RRB-
cord-022313-2675sjlf	516	37	.	.	.
cord-022313-2675sjlf	517	1	These	these	DT
cord-022313-2675sjlf	517	2	plants	plant	NNS
cord-022313-2675sjlf	517	3	present	present	VBP
cord-022313-2675sjlf	517	4	a	a	DT
cord-022313-2675sjlf	517	5	major	major	JJ
cord-022313-2675sjlf	517	6	hazard	hazard	NN
cord-022313-2675sjlf	517	7	to	to	IN
cord-022313-2675sjlf	517	8	the	the	DT
cord-022313-2675sjlf	517	9	livestock	livestock	NN
cord-022313-2675sjlf	517	10	industry	industry	NN
cord-022313-2675sjlf	517	11	and	and	CC
cord-022313-2675sjlf	517	12	cause	cause	VB
cord-022313-2675sjlf	517	13	severe	severe	JJ
cord-022313-2675sjlf	517	14	neurological	neurological	JJ
cord-022313-2675sjlf	517	15	and	and	CC
cord-022313-2675sjlf	517	16	skeletal	skeletal	JJ
cord-022313-2675sjlf	517	17	problems	problem	NNS
cord-022313-2675sjlf	517	18	in	in	IN
cord-022313-2675sjlf	517	19	animals	animal	NNS
cord-022313-2675sjlf	517	20	that	that	WDT
cord-022313-2675sjlf	517	21	feed	feed	VBP
cord-022313-2675sjlf	517	22	on	on	IN
cord-022313-2675sjlf	517	23	them	-PRON-	PRP
cord-022313-2675sjlf	517	24	.	.	.
cord-022313-2675sjlf	518	1	Early	early	JJ
cord-022313-2675sjlf	518	2	studies	study	NNS
cord-022313-2675sjlf	518	3	on	on	IN
cord-022313-2675sjlf	518	4	the	the	DT
cord-022313-2675sjlf	518	5	inhibition	inhibition	NN
cord-022313-2675sjlf	518	6	of	of	IN
cord-022313-2675sjlf	518	7	aryl	aryl	RB
cord-022313-2675sjlf	518	8	-	-	HYPH
cord-022313-2675sjlf	518	9	a	a	DT
cord-022313-2675sjlf	518	10	-	-	HYPH
cord-022313-2675sjlf	518	11	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	518	12	by	by	IN
cord-022313-2675sjlf	518	13	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	518	14	sug	sug	NNP
cord-022313-2675sjlf	518	15	gested	geste	VBD
cord-022313-2675sjlf	518	16	that	that	IN
cord-022313-2675sjlf	518	17	its	-PRON-	PRP$
cord-022313-2675sjlf	518	18	potent	potent	JJ
cord-022313-2675sjlf	518	19	inhibitory	inhibitory	JJ
cord-022313-2675sjlf	518	20	activity	activity	NN
cord-022313-2675sjlf	518	21	(	(	-LRB-
cord-022313-2675sjlf	518	22	IC	IC	NNP
cord-022313-2675sjlf	518	23	50	50	CD
cord-022313-2675sjlf	518	24	=	=	SYM
cord-022313-2675sjlf	518	25	1	1	CD
cord-022313-2675sjlf	518	26	χ	χ	CD
cord-022313-2675sjlf	518	27	10	10	CD
cord-022313-2675sjlf	518	28	"	"	``
cord-022313-2675sjlf	518	29	7	7	CD
cord-022313-2675sjlf	518	30	M	M	NNP
cord-022313-2675sjlf	518	31	)	)	-RRB-
cord-022313-2675sjlf	518	32	resulted	result	VBD
cord-022313-2675sjlf	518	33	from	from	IN
cord-022313-2675sjlf	518	34	the	the	DT
cord-022313-2675sjlf	518	35	structural	structural	JJ
cord-022313-2675sjlf	518	36	similarity	similarity	NN
cord-022313-2675sjlf	518	37	of	of	IN
cord-022313-2675sjlf	518	38	the	the	DT
cord-022313-2675sjlf	518	39	protonated	protonated	JJ
cord-022313-2675sjlf	518	40	form	form	NN
cord-022313-2675sjlf	518	41	of	of	IN
cord-022313-2675sjlf	518	42	swainsonine	swainsonine	NN
cord-022313-2675sjlf	518	43	to	to	IN
cord-022313-2675sjlf	518	44	that	that	DT
cord-022313-2675sjlf	518	45	of	of	IN
cord-022313-2675sjlf	518	46	the	the	DT
cord-022313-2675sjlf	518	47	mannosyl	mannosyl	NNP
cord-022313-2675sjlf	518	48	cation	cation	NNP
cord-022313-2675sjlf	518	49	,	,	,
cord-022313-2675sjlf	518	50	since	since	IN
cord-022313-2675sjlf	518	51	the	the	DT
cord-022313-2675sjlf	518	52	glycosyl	glycosyl	NN
cord-022313-2675sjlf	518	53	ion	ion	NN
cord-022313-2675sjlf	518	54	intermediate	intermediate	NN
cord-022313-2675sjlf	518	55	is	be	VBZ
cord-022313-2675sjlf	518	56	probably	probably	RB
cord-022313-2675sjlf	518	57	formed	form	VBN
cord-022313-2675sjlf	518	58	during	during	IN
cord-022313-2675sjlf	518	59	natural	natural	JJ
cord-022313-2675sjlf	518	60	hydrolysis	hydrolysis	NN
cord-022313-2675sjlf	518	61	by	by	IN
cord-022313-2675sjlf	518	62	glycosidases	glycosidases	NNP
cord-022313-2675sjlf	518	63	(	(	-LRB-
cord-022313-2675sjlf	518	64	203	203	CD
cord-022313-2675sjlf	518	65	)	)	-RRB-
cord-022313-2675sjlf	518	66	.	.	.
cord-022313-2675sjlf	519	1	Lymphnodes	lymphnode	NNS
cord-022313-2675sjlf	519	2	of	of	IN
cord-022313-2675sjlf	519	3	sheep	sheep	NNS
cord-022313-2675sjlf	519	4	that	that	WDT
cord-022313-2675sjlf	519	5	had	have	VBD
cord-022313-2675sjlf	519	6	injested	injeste	VBN
cord-022313-2675sjlf	519	7	these	these	DT
cord-022313-2675sjlf	519	8	toxic	toxic	JJ
cord-022313-2675sjlf	519	9	plants	plant	NNS
cord-022313-2675sjlf	519	10	contained	contain	VBD
cord-022313-2675sjlf	519	11	high	high	JJ
cord-022313-2675sjlf	519	12	levels	level	NNS
cord-022313-2675sjlf	519	13	of	of	IN
cord-022313-2675sjlf	519	14	mannose	mannose	NN
cord-022313-2675sjlf	519	15	-	-	HYPH
cord-022313-2675sjlf	519	16	rich	rich	JJ
cord-022313-2675sjlf	519	17	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	519	18	(	(	-LRB-
cord-022313-2675sjlf	519	19	204	204	CD
cord-022313-2675sjlf	519	20	)	)	-RRB-
cord-022313-2675sjlf	519	21	,	,	,
cord-022313-2675sjlf	519	22	which	which	WDT
cord-022313-2675sjlf	519	23	led	lead	VBD
cord-022313-2675sjlf	519	24	to	to	IN
cord-022313-2675sjlf	519	25	the	the	DT
cord-022313-2675sjlf	519	26	postulation	postulation	NN
cord-022313-2675sjlf	519	27	that	that	IN
cord-022313-2675sjlf	519	28	swainsonine	swainsonine	NN
cord-022313-2675sjlf	519	29	causes	cause	VBZ
cord-022313-2675sjlf	519	30	a	a	DT
cord-022313-2675sjlf	519	31	"	"	``
cord-022313-2675sjlf	519	32	lysosomal	lysosomal	NN
cord-022313-2675sjlf	519	33	-	-	HYPH
cord-022313-2675sjlf	519	34	like	like	JJ
cord-022313-2675sjlf	519	35	"	"	''
cord-022313-2675sjlf	519	36	storage	storage	NN
cord-022313-2675sjlf	519	37	disease	disease	NN
cord-022313-2675sjlf	519	38	that	that	WDT
cord-022313-2675sjlf	519	39	is	be	VBZ
cord-022313-2675sjlf	519	40	similar	similar	JJ
cord-022313-2675sjlf	519	41	to	to	IN
cord-022313-2675sjlf	519	42	that	that	DT
cord-022313-2675sjlf	519	43	of	of	IN
cord-022313-2675sjlf	519	44	human	human	JJ
cord-022313-2675sjlf	519	45	α	α	NN
cord-022313-2675sjlf	519	46	-	-	HYPH
cord-022313-2675sjlf	519	47	mannosidosis	mannosidosis	NNP
cord-022313-2675sjlf	519	48	,	,	,
cord-022313-2675sjlf	519	49	both	both	CC
cord-022313-2675sjlf	519	50	morphologically	morphologically	RB
cord-022313-2675sjlf	519	51	and	and	CC
cord-022313-2675sjlf	519	52	biochemically	biochemically	RB
cord-022313-2675sjlf	519	53	.	.	.
cord-022313-2675sjlf	520	1	That	that	DT
cord-022313-2675sjlf	520	2	swainsonine	swainsonine	NN
cord-022313-2675sjlf	520	3	is	be	VBZ
cord-022313-2675sjlf	520	4	actually	actually	RB
cord-022313-2675sjlf	520	5	the	the	DT
cord-022313-2675sjlf	520	6	causative	causative	JJ
cord-022313-2675sjlf	520	7	agent	agent	NN
cord-022313-2675sjlf	520	8	of	of	IN
cord-022313-2675sjlf	520	9	these	these	DT
cord-022313-2675sjlf	520	10	symptoms	symptom	NNS
cord-022313-2675sjlf	520	11	was	be	VBD
cord-022313-2675sjlf	520	12	indicated	indicate	VBN
cord-022313-2675sjlf	520	13	by	by	IN
cord-022313-2675sjlf	520	14	feeding	feed	VBG
cord-022313-2675sjlf	520	15	pigs	pig	NNS
cord-022313-2675sjlf	520	16	either	either	CC
cord-022313-2675sjlf	520	17	the	the	DT
cord-022313-2675sjlf	520	18	whole	whole	JJ
cord-022313-2675sjlf	520	19	toxic	toxic	JJ
cord-022313-2675sjlf	520	20	plant	plant	NN
cord-022313-2675sjlf	520	21	(	(	-LRB-
cord-022313-2675sjlf	520	22	i.e.	i.e.	FW
cord-022313-2675sjlf	520	23	,	,	,
cord-022313-2675sjlf	520	24	Astragalus	Astragalus	NNP
cord-022313-2675sjlf	520	25	)	)	-RRB-
cord-022313-2675sjlf	520	26	or	or	CC
cord-022313-2675sjlf	520	27	swainsonine	swainsonine	NN
cord-022313-2675sjlf	520	28	and	and	CC
cord-022313-2675sjlf	520	29	showing	show	VBG
cord-022313-2675sjlf	520	30	that	that	IN
cord-022313-2675sjlf	520	31	both	both	DT
cord-022313-2675sjlf	520	32	sets	set	NNS
cord-022313-2675sjlf	520	33	of	of	IN
cord-022313-2675sjlf	520	34	animals	animal	NNS
cord-022313-2675sjlf	520	35	exhibited	exhibit	VBD
cord-022313-2675sjlf	520	36	the	the	DT
cord-022313-2675sjlf	520	37	same	same	JJ
cord-022313-2675sjlf	520	38	symptoms	symptom	NNS
cord-022313-2675sjlf	520	39	(	(	-LRB-
cord-022313-2675sjlf	520	40	205	205	CD
cord-022313-2675sjlf	520	41	)	)	-RRB-
cord-022313-2675sjlf	520	42	.	.	.
cord-022313-2675sjlf	521	1	In	in	IN
cord-022313-2675sjlf	521	2	these	these	DT
cord-022313-2675sjlf	521	3	animals	animal	NNS
cord-022313-2675sjlf	521	4	,	,	,
cord-022313-2675sjlf	521	5	liver	liver	NN
cord-022313-2675sjlf	521	6	Golgi	Golgi	NNP
cord-022313-2675sjlf	521	7	mannosidase	mannosidase	NN
cord-022313-2675sjlf	521	8	II	ii	CD
cord-022313-2675sjlf	521	9	activity	activity	NN
cord-022313-2675sjlf	521	10	was	be	VBD
cord-022313-2675sjlf	521	11	significantly	significantly	RB
cord-022313-2675sjlf	521	12	decreased	decrease	VBN
cord-022313-2675sjlf	521	13	,	,	,
cord-022313-2675sjlf	521	14	but	but	CC
cord-022313-2675sjlf	521	15	strangely	strangely	RB
cord-022313-2675sjlf	521	16	enough	enough	RB
cord-022313-2675sjlf	521	17	,	,	,
cord-022313-2675sjlf	521	18	a	a	DT
cord-022313-2675sjlf	521	19	number	number	NN
cord-022313-2675sjlf	521	20	of	of	IN
cord-022313-2675sjlf	521	21	lysosomal	lysosomal	JJ
cord-022313-2675sjlf	521	22	hydrolases	hydrolase	NNS
cord-022313-2675sjlf	521	23	such	such	JJ
cord-022313-2675sjlf	521	24	as	as	IN
cord-022313-2675sjlf	521	25	amannosidase	amannosidase	NN
cord-022313-2675sjlf	521	26	,	,	,
cord-022313-2675sjlf	521	27	α	α	NN
cord-022313-2675sjlf	521	28	-	-	HYPH
cord-022313-2675sjlf	521	29	fucosidase	fucosidase	NN
cord-022313-2675sjlf	521	30	,	,	,
cord-022313-2675sjlf	521	31	and	and	CC
cord-022313-2675sjlf	521	32	^-hexosaminidase	^-hexosaminidase	NNP
cord-022313-2675sjlf	521	33	increased	increase	VBD
cord-022313-2675sjlf	521	34	in	in	IN
cord-022313-2675sjlf	521	35	activ	activ	JJ
cord-022313-2675sjlf	521	36	ity	ity	NN
cord-022313-2675sjlf	521	37	.	.	.
cord-022313-2675sjlf	522	1	In	in	IN
cord-022313-2675sjlf	522	2	addition	addition	NN
cord-022313-2675sjlf	522	3	,	,	,
cord-022313-2675sjlf	522	4	the	the	DT
cord-022313-2675sjlf	522	5	activity	activity	NN
cord-022313-2675sjlf	522	6	of	of	IN
cord-022313-2675sjlf	522	7	various	various	JJ
cord-022313-2675sjlf	522	8	hydrolases	hydrolase	NNS
cord-022313-2675sjlf	522	9	in	in	IN
cord-022313-2675sjlf	522	10	the	the	DT
cord-022313-2675sjlf	522	11	plasma	plasma	NN
cord-022313-2675sjlf	522	12	was	be	VBD
cord-022313-2675sjlf	522	13	also	also	RB
cord-022313-2675sjlf	522	14	elevated	elevate	VBN
cord-022313-2675sjlf	522	15	.	.	.
cord-022313-2675sjlf	523	1	In	in	IN
cord-022313-2675sjlf	523	2	sheep	sheep	NN
cord-022313-2675sjlf	523	3	fed	fed	NNP
cord-022313-2675sjlf	523	4	locoweed	locowee	VBD
cord-022313-2675sjlf	523	5	,	,	,
cord-022313-2675sjlf	523	6	various	various	JJ
cord-022313-2675sjlf	523	7	high	high	JJ
cord-022313-2675sjlf	523	8	-	-	HYPH
cord-022313-2675sjlf	523	9	mannose	mannose	NN
cord-022313-2675sjlf	523	10	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	523	11	were	be	VBD
cord-022313-2675sjlf	523	12	found	find	VBN
cord-022313-2675sjlf	523	13	in	in	IN
cord-022313-2675sjlf	523	14	the	the	DT
cord-022313-2675sjlf	523	15	urine	urine	NN
cord-022313-2675sjlf	523	16	and	and	CC
cord-022313-2675sjlf	523	17	the	the	DT
cord-022313-2675sjlf	523	18	two	two	CD
cord-022313-2675sjlf	523	19	major	major	JJ
cord-022313-2675sjlf	523	20	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	523	21	were	be	VBD
cord-022313-2675sjlf	523	22	identi	identi	VBN
cord-022313-2675sjlf	523	23	fied	fie	VBN
cord-022313-2675sjlf	523	24	as	as	IN
cord-022313-2675sjlf	523	25	Man	Man	NNP
cord-022313-2675sjlf	523	26	4	4	CD
cord-022313-2675sjlf	523	27	(	(	-LRB-
cord-022313-2675sjlf	523	28	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	523	29	)	)	-RRB-
cord-022313-2675sjlf	523	30	2	2	CD
cord-022313-2675sjlf	523	31	and	and	CC
cord-022313-2675sjlf	523	32	Man	Man	NNP
cord-022313-2675sjlf	523	33	6	6	CD
cord-022313-2675sjlf	523	34	(	(	-LRB-
cord-022313-2675sjlf	523	35	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	523	36	)	)	-RRB-
cord-022313-2675sjlf	523	37	6	6	CD
cord-022313-2675sjlf	523	38	(	(	-LRB-
cord-022313-2675sjlf	523	39	206	206	CD
cord-022313-2675sjlf	523	40	)	)	-RRB-
cord-022313-2675sjlf	523	41	.	.	.
cord-022313-2675sjlf	524	1	The	the	DT
cord-022313-2675sjlf	524	2	relative	relative	JJ
cord-022313-2675sjlf	524	3	abun	abun	NN
cord-022313-2675sjlf	524	4	dance	dance	NN
cord-022313-2675sjlf	524	5	of	of	IN
cord-022313-2675sjlf	524	6	the	the	DT
cord-022313-2675sjlf	524	7	various	various	JJ
cord-022313-2675sjlf	524	8	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	524	9	changed	change	VBN
cord-022313-2675sjlf	524	10	over	over	IN
cord-022313-2675sjlf	524	11	the	the	DT
cord-022313-2675sjlf	524	12	course	course	NN
cord-022313-2675sjlf	524	13	of	of	IN
cord-022313-2675sjlf	524	14	the	the	DT
cord-022313-2675sjlf	524	15	feeding	feeding	NN
cord-022313-2675sjlf	524	16	,	,	,
cord-022313-2675sjlf	524	17	but	but	CC
cord-022313-2675sjlf	524	18	when	when	WRB
cord-022313-2675sjlf	524	19	the	the	DT
cord-022313-2675sjlf	524	20	feeding	feeding	NN
cord-022313-2675sjlf	524	21	was	be	VBD
cord-022313-2675sjlf	524	22	discontinued	discontinue	VBN
cord-022313-2675sjlf	524	23	,	,	,
cord-022313-2675sjlf	524	24	the	the	DT
cord-022313-2675sjlf	524	25	amount	amount	NN
cord-022313-2675sjlf	524	26	of	of	IN
cord-022313-2675sjlf	524	27	urinary	urinary	JJ
cord-022313-2675sjlf	524	28	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	524	29	declined	decline	VBD
cord-022313-2675sjlf	524	30	rapidly	rapidly	RB
cord-022313-2675sjlf	524	31	and	and	CC
cord-022313-2675sjlf	524	32	reached	reach	VBD
cord-022313-2675sjlf	524	33	a	a	DT
cord-022313-2675sjlf	524	34	baseline	baseline	NN
cord-022313-2675sjlf	524	35	within	within	IN
cord-022313-2675sjlf	524	36	about	about	RB
cord-022313-2675sjlf	524	37	12	12	CD
cord-022313-2675sjlf	524	38	days	day	NNS
cord-022313-2675sjlf	524	39	.	.	.
cord-022313-2675sjlf	525	1	Similar	similar	JJ
cord-022313-2675sjlf	525	2	types	type	NNS
cord-022313-2675sjlf	525	3	of	of	IN
cord-022313-2675sjlf	525	4	high	high	JJ
cord-022313-2675sjlf	525	5	-	-	HYPH
cord-022313-2675sjlf	525	6	mannose	mannose	NN
cord-022313-2675sjlf	525	7	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	525	8	also	also	RB
cord-022313-2675sjlf	525	9	accumu	accumu	VBN
cord-022313-2675sjlf	525	10	lated	late	VBN
cord-022313-2675sjlf	525	11	in	in	IN
cord-022313-2675sjlf	525	12	rats	rat	NNS
cord-022313-2675sjlf	525	13	and	and	CC
cord-022313-2675sjlf	525	14	guinea	guinea	NN
cord-022313-2675sjlf	525	15	pigs	pig	NNS
cord-022313-2675sjlf	525	16	fed	feed	VBD
cord-022313-2675sjlf	525	17	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	525	18	,	,	,
cord-022313-2675sjlf	525	19	but	but	CC
cord-022313-2675sjlf	525	20	there	there	EX
cord-022313-2675sjlf	525	21	were	be	VBD
cord-022313-2675sjlf	525	22	some	some	DT
cord-022313-2675sjlf	525	23	differences	difference	NNS
cord-022313-2675sjlf	525	24	in	in	IN
cord-022313-2675sjlf	525	25	the	the	DT
cord-022313-2675sjlf	525	26	structures	structure	NNS
cord-022313-2675sjlf	525	27	,	,	,
cord-022313-2675sjlf	525	28	especially	especially	RB
cord-022313-2675sjlf	525	29	the	the	DT
cord-022313-2675sjlf	525	30	presence	presence	NN
cord-022313-2675sjlf	525	31	of	of	IN
cord-022313-2675sjlf	525	32	one	one	CD
cord-022313-2675sjlf	525	33	or	or	CC
cord-022313-2675sjlf	525	34	two	two	CD
cord-022313-2675sjlf	525	35	GlcNAc	glcnac	NN
cord-022313-2675sjlf	525	36	residues	residue	NNS
cord-022313-2675sjlf	525	37	at	at	IN
cord-022313-2675sjlf	525	38	and	and	CC
cord-022313-2675sjlf	525	39	near	near	IN
cord-022313-2675sjlf	525	40	the	the	DT
cord-022313-2675sjlf	525	41	reducing	reduce	VBG
cord-022313-2675sjlf	525	42	terminus	terminus	NN
cord-022313-2675sjlf	525	43	(	(	-LRB-
cord-022313-2675sjlf	525	44	207	207	CD
cord-022313-2675sjlf	525	45	)	)	-RRB-
cord-022313-2675sjlf	525	46	.	.	.
cord-022313-2675sjlf	526	1	These	these	DT
cord-022313-2675sjlf	526	2	differ	differ	VBP
cord-022313-2675sjlf	527	1	ences	ence	NNS
cord-022313-2675sjlf	527	2	probably	probably	RB
cord-022313-2675sjlf	527	3	reflect	reflect	VBP
cord-022313-2675sjlf	527	4	the	the	DT
cord-022313-2675sjlf	527	5	presence	presence	NN
cord-022313-2675sjlf	527	6	or	or	CC
cord-022313-2675sjlf	527	7	absence	absence	NN
cord-022313-2675sjlf	527	8	of	of	IN
cord-022313-2675sjlf	527	9	an	an	DT
cord-022313-2675sjlf	527	10	endoglucosaminidase	endoglucosaminidase	NN
cord-022313-2675sjlf	527	11	in	in	IN
cord-022313-2675sjlf	527	12	some	some	DT
cord-022313-2675sjlf	527	13	of	of	IN
cord-022313-2675sjlf	527	14	these	these	DT
cord-022313-2675sjlf	527	15	animals	animal	NNS
cord-022313-2675sjlf	527	16	.	.	.
cord-022313-2675sjlf	528	1	Swainsonine	Swainsonine	NNP
cord-022313-2675sjlf	528	2	was	be	VBD
cord-022313-2675sjlf	528	3	the	the	DT
cord-022313-2675sjlf	528	4	first	first	JJ
cord-022313-2675sjlf	528	5	compound	compound	NN
cord-022313-2675sjlf	528	6	that	that	WDT
cord-022313-2675sjlf	528	7	was	be	VBD
cord-022313-2675sjlf	528	8	shown	show	VBN
cord-022313-2675sjlf	528	9	to	to	TO
cord-022313-2675sjlf	528	10	inhibit	inhibit	VB
cord-022313-2675sjlf	528	11	glyco	glyco	NNP
cord-022313-2675sjlf	528	12	protein	protein	NN
cord-022313-2675sjlf	528	13	processing	processing	NN
cord-022313-2675sjlf	528	14	(	(	-LRB-
cord-022313-2675sjlf	528	15	186	186	CD
cord-022313-2675sjlf	528	16	)	)	-RRB-
cord-022313-2675sjlf	528	17	.	.	.
cord-022313-2675sjlf	529	1	In	in	IN
cord-022313-2675sjlf	529	2	the	the	DT
cord-022313-2675sjlf	529	3	initial	initial	JJ
cord-022313-2675sjlf	529	4	studies	study	NNS
cord-022313-2675sjlf	529	5	,	,	,
cord-022313-2675sjlf	529	6	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	529	7	was	be	VBD
cord-022313-2675sjlf	529	8	added	add	VBN
cord-022313-2675sjlf	529	9	to	to	IN
cord-022313-2675sjlf	529	10	the	the	DT
cord-022313-2675sjlf	529	11	culture	culture	NN
cord-022313-2675sjlf	529	12	medium	medium	NN
cord-022313-2675sjlf	529	13	of	of	IN
cord-022313-2675sjlf	529	14	MDCK	MDCK	NNP
cord-022313-2675sjlf	529	15	cells	cell	NNS
cord-022313-2675sjlf	529	16	and	and	CC
cord-022313-2675sjlf	529	17	was	be	VBD
cord-022313-2675sjlf	529	18	found	find	VBN
cord-022313-2675sjlf	529	19	to	to	TO
cord-022313-2675sjlf	529	20	cause	cause	VB
cord-022313-2675sjlf	529	21	a	a	DT
cord-022313-2675sjlf	529	22	great	great	JJ
cord-022313-2675sjlf	529	23	decrease	decrease	NN
cord-022313-2675sjlf	529	24	in	in	IN
cord-022313-2675sjlf	529	25	the	the	DT
cord-022313-2675sjlf	529	26	amount	amount	NN
cord-022313-2675sjlf	529	27	of	of	IN
cord-022313-2675sjlf	529	28	[	[	-LRB-
cord-022313-2675sjlf	529	29	2	2	CD
cord-022313-2675sjlf	529	30	-	-	SYM
cord-022313-2675sjlf	529	31	3	3	CD
cord-022313-2675sjlf	529	32	H]mannose	H]mannose	NNP
cord-022313-2675sjlf	529	33	incorported	incorporte	VBD
cord-022313-2675sjlf	529	34	into	into	IN
cord-022313-2675sjlf	529	35	complex	complex	JJ
cord-022313-2675sjlf	529	36	types	type	NNS
cord-022313-2675sjlf	529	37	of	of	IN
cord-022313-2675sjlf	529	38	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	529	39	and	and	CC
cord-022313-2675sjlf	529	40	a	a	DT
cord-022313-2675sjlf	529	41	corresponding	corresponding	JJ
cord-022313-2675sjlf	529	42	increase	increase	NN
cord-022313-2675sjlf	529	43	in	in	IN
cord-022313-2675sjlf	529	44	incorporation	incorporation	NN
cord-022313-2675sjlf	529	45	of	of	IN
cord-022313-2675sjlf	529	46	labeled	label	VBN
cord-022313-2675sjlf	529	47	sugar	sugar	NN
cord-022313-2675sjlf	529	48	into	into	IN
cord-022313-2675sjlf	529	49	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	529	50	that	that	WDT
cord-022313-2675sjlf	529	51	were	be	VBD
cord-022313-2675sjlf	529	52	sensitive	sensitive	JJ
cord-022313-2675sjlf	529	53	to	to	IN
cord-022313-2675sjlf	529	54	digestion	digestion	NN
cord-022313-2675sjlf	529	55	by	by	IN
cord-022313-2675sjlf	529	56	endoglucosaminidase	endoglucosaminidase	NN
cord-022313-2675sjlf	529	57	H.	H.	NNP
cord-022313-2675sjlf	530	1	In	in	IN
cord-022313-2675sjlf	530	2	influenza	influenza	NN
cord-022313-2675sjlf	530	3	-	-	HYPH
cord-022313-2675sjlf	530	4	virus	virus	NN
cord-022313-2675sjlf	530	5	-	-	HYPH
cord-022313-2675sjlf	530	6	infected	infect	VBN
cord-022313-2675sjlf	530	7	MDCK	MDCK	NNP
cord-022313-2675sjlf	530	8	cells	cell	NNS
cord-022313-2675sjlf	530	9	,	,	,
cord-022313-2675sjlf	530	10	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	530	11	caused	cause	VBD
cord-022313-2675sjlf	530	12	the	the	DT
cord-022313-2675sjlf	530	13	viral	viral	JJ
cord-022313-2675sjlf	530	14	hemagglutinin	hemagglutinin	NN
cord-022313-2675sjlf	530	15	,	,	,
cord-022313-2675sjlf	530	16	an	an	DT
cord-022313-2675sjlf	530	17	N	n	NN
cord-022313-2675sjlf	530	18	-	-	HYPH
cord-022313-2675sjlf	530	19	linked	link	VBN
cord-022313-2675sjlf	530	20	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	530	21	with	with	IN
cord-022313-2675sjlf	530	22	several	several	JJ
cord-022313-2675sjlf	530	23	complex	complex	JJ
cord-022313-2675sjlf	530	24	chains	chain	NNS
cord-022313-2675sjlf	530	25	,	,	,
cord-022313-2675sjlf	530	26	to	to	TO
cord-022313-2675sjlf	530	27	migrate	migrate	VB
cord-022313-2675sjlf	530	28	more	more	RBR
cord-022313-2675sjlf	530	29	rapidly	rapidly	RB
cord-022313-2675sjlf	530	30	on	on	IN
cord-022313-2675sjlf	530	31	SDS	SDS	NNP
cord-022313-2675sjlf	530	32	gels	gel	NNS
cord-022313-2675sjlf	530	33	,	,	,
cord-022313-2675sjlf	530	34	and	and	CC
cord-022313-2675sjlf	530	35	these	these	DT
cord-022313-2675sjlf	530	36	changes	change	NNS
cord-022313-2675sjlf	530	37	were	be	VBD
cord-022313-2675sjlf	530	38	shown	show	VBN
cord-022313-2675sjlf	530	39	to	to	TO
cord-022313-2675sjlf	530	40	be	be	VB
cord-022313-2675sjlf	530	41	due	due	JJ
cord-022313-2675sjlf	530	42	to	to	IN
cord-022313-2675sjlf	530	43	changes	change	NNS
cord-022313-2675sjlf	530	44	in	in	IN
cord-022313-2675sjlf	530	45	the	the	DT
cord-022313-2675sjlf	530	46	structure	structure	NN
cord-022313-2675sjlf	530	47	of	of	IN
cord-022313-2675sjlf	530	48	the	the	DT
cord-022313-2675sjlf	530	49	N	n	NN
cord-022313-2675sjlf	530	50	-	-	HYPH
cord-022313-2675sjlf	530	51	linked	link	VBN
cord-022313-2675sjlf	530	52	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	530	53	(	(	-LRB-
cord-022313-2675sjlf	530	54	208	208	CD
cord-022313-2675sjlf	530	55	)	)	-RRB-
cord-022313-2675sjlf	530	56	.	.	.
cord-022313-2675sjlf	531	1	Later	later	JJ
cord-022313-2675sjlf	531	2	studies	study	NNS
cord-022313-2675sjlf	531	3	with	with	IN
cord-022313-2675sjlf	531	4	purified	purify	VBN
cord-022313-2675sjlf	531	5	processing	processing	NN
cord-022313-2675sjlf	531	6	enzymes	enzyme	NNS
cord-022313-2675sjlf	531	7	showed	show	VBD
cord-022313-2675sjlf	531	8	that	that	IN
cord-022313-2675sjlf	531	9	the	the	DT
cord-022313-2675sjlf	531	10	site	site	NN
cord-022313-2675sjlf	531	11	of	of	IN
cord-022313-2675sjlf	531	12	action	action	NN
cord-022313-2675sjlf	531	13	of	of	IN
cord-022313-2675sjlf	531	14	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	531	15	was	be	VBD
cord-022313-2675sjlf	531	16	the	the	DT
cord-022313-2675sjlf	531	17	Golgi	Golgi	NNP
cord-022313-2675sjlf	531	18	mannosidase	mannosidase	NN
cord-022313-2675sjlf	531	19	II	II	NNP
cord-022313-2675sjlf	531	20	and	and	CC
cord-022313-2675sjlf	531	21	that	that	IN
cord-022313-2675sjlf	531	22	this	this	DT
cord-022313-2675sjlf	531	23	alkaloid	alkaloid	NN
cord-022313-2675sjlf	531	24	was	be	VBD
cord-022313-2675sjlf	531	25	inactive	inactive	JJ
cord-022313-2675sjlf	531	26	toward	toward	IN
cord-022313-2675sjlf	531	27	the	the	DT
cord-022313-2675sjlf	531	28	pro	pro	JJ
cord-022313-2675sjlf	531	29	cessing	cessing	NN
cord-022313-2675sjlf	531	30	mannosidase	mannosidase	NN
cord-022313-2675sjlf	531	31	I	-PRON-	PRP
cord-022313-2675sjlf	531	32	(	(	-LRB-
cord-022313-2675sjlf	531	33	188	188	CD
cord-022313-2675sjlf	531	34	)	)	-RRB-
cord-022313-2675sjlf	531	35	.	.	.
cord-022313-2675sjlf	532	1	In	in	IN
cord-022313-2675sjlf	532	2	keeping	keep	VBG
cord-022313-2675sjlf	532	3	with	with	IN
cord-022313-2675sjlf	532	4	this	this	DT
cord-022313-2675sjlf	532	5	site	site	NN
cord-022313-2675sjlf	532	6	of	of	IN
cord-022313-2675sjlf	532	7	action	action	NN
cord-022313-2675sjlf	532	8	,	,	,
cord-022313-2675sjlf	532	9	this	this	DT
cord-022313-2675sjlf	532	10	indolizidine	indolizidine	NN
cord-022313-2675sjlf	532	11	alkaloid	alkaloid	NN
cord-022313-2675sjlf	532	12	also	also	RB
cord-022313-2675sjlf	532	13	caused	cause	VBD
cord-022313-2675sjlf	532	14	the	the	DT
cord-022313-2675sjlf	532	15	formation	formation	NN
cord-022313-2675sjlf	532	16	of	of	IN
cord-022313-2675sjlf	532	17	hybrid	hybrid	JJ
cord-022313-2675sjlf	532	18	types	type	NNS
cord-022313-2675sjlf	532	19	of	of	IN
cord-022313-2675sjlf	532	20	struc	struc	JJ
cord-022313-2675sjlf	532	21	tures	tures	NNP
cord-022313-2675sjlf	532	22	when	when	WRB
cord-022313-2675sjlf	532	23	it	-PRON-	PRP
cord-022313-2675sjlf	532	24	was	be	VBD
cord-022313-2675sjlf	532	25	placed	place	VBN
cord-022313-2675sjlf	532	26	in	in	IN
cord-022313-2675sjlf	532	27	the	the	DT
cord-022313-2675sjlf	532	28	culture	culture	NN
cord-022313-2675sjlf	532	29	medium	medium	NN
cord-022313-2675sjlf	532	30	of	of	IN
cord-022313-2675sjlf	532	31	cells	cell	NNS
cord-022313-2675sjlf	532	32	producing	produce	VBG
cord-022313-2675sjlf	532	33	various	various	JJ
cord-022313-2675sjlf	532	34	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	532	35	such	such	JJ
cord-022313-2675sjlf	532	36	as	as	IN
cord-022313-2675sjlf	532	37	the	the	DT
cord-022313-2675sjlf	532	38	VSV	VSV	NNP
cord-022313-2675sjlf	532	39	G	G	NNP
cord-022313-2675sjlf	532	40	protein	protein	NN
cord-022313-2675sjlf	532	41	(	(	-LRB-
cord-022313-2675sjlf	532	42	209	209	CD
cord-022313-2675sjlf	532	43	)	)	-RRB-
cord-022313-2675sjlf	532	44	,	,	,
cord-022313-2675sjlf	532	45	fibronectin	fibronectin	NN
cord-022313-2675sjlf	532	46	(	(	-LRB-
cord-022313-2675sjlf	532	47	210	210	CD
cord-022313-2675sjlf	532	48	)	)	-RRB-
cord-022313-2675sjlf	532	49	,	,	,
cord-022313-2675sjlf	532	50	and	and	CC
cord-022313-2675sjlf	532	51	BHK	BHK	NNP
cord-022313-2675sjlf	532	52	cell	cell	NN
cord-022313-2675sjlf	532	53	surface	surface	NN
cord-022313-2675sjlf	532	54	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	532	55	(	(	-LRB-
cord-022313-2675sjlf	532	56	211	211	CD
cord-022313-2675sjlf	532	57	)	)	-RRB-
cord-022313-2675sjlf	532	58	.	.	.
cord-022313-2675sjlf	533	1	Swainsonine	Swainsonine	NNP
cord-022313-2675sjlf	533	2	has	have	VBZ
cord-022313-2675sjlf	533	3	been	be	VBN
cord-022313-2675sjlf	533	4	used	use	VBN
cord-022313-2675sjlf	533	5	with	with	IN
cord-022313-2675sjlf	533	6	a	a	DT
cord-022313-2675sjlf	533	7	number	number	NN
cord-022313-2675sjlf	533	8	of	of	IN
cord-022313-2675sjlf	533	9	cell	cell	NN
cord-022313-2675sjlf	533	10	culture	culture	NN
cord-022313-2675sjlf	533	11	systems	system	NNS
cord-022313-2675sjlf	533	12	to	to	TO
cord-022313-2675sjlf	533	13	try	try	VB
cord-022313-2675sjlf	533	14	and	and	CC
cord-022313-2675sjlf	533	15	determine	determine	VB
cord-022313-2675sjlf	533	16	the	the	DT
cord-022313-2675sjlf	533	17	role	role	NN
cord-022313-2675sjlf	533	18	of	of	IN
cord-022313-2675sjlf	533	19	specific	specific	JJ
cord-022313-2675sjlf	533	20	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	533	21	structures	structure	NNS
cord-022313-2675sjlf	533	22	in	in	IN
cord-022313-2675sjlf	533	23	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	533	24	function	function	NN
cord-022313-2675sjlf	533	25	.	.	.
cord-022313-2675sjlf	534	1	In	in	IN
cord-022313-2675sjlf	534	2	most	most	JJS
cord-022313-2675sjlf	534	3	of	of	IN
cord-022313-2675sjlf	534	4	these	these	DT
cord-022313-2675sjlf	534	5	studies	study	NNS
cord-022313-2675sjlf	534	6	,	,	,
cord-022313-2675sjlf	534	7	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	534	8	was	be	VBD
cord-022313-2675sjlf	534	9	found	find	VBN
cord-022313-2675sjlf	534	10	to	to	TO
cord-022313-2675sjlf	534	11	have	have	VB
cord-022313-2675sjlf	534	12	little	little	JJ
cord-022313-2675sjlf	534	13	effect	effect	NN
cord-022313-2675sjlf	534	14	on	on	IN
cord-022313-2675sjlf	534	15	the	the	DT
cord-022313-2675sjlf	534	16	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	534	17	in	in	IN
cord-022313-2675sjlf	534	18	question	question	NN
cord-022313-2675sjlf	534	19	,	,	,
cord-022313-2675sjlf	534	20	indicating	indicate	VBG
cord-022313-2675sjlf	534	21	that	that	IN
cord-022313-2675sjlf	534	22	a	a	DT
cord-022313-2675sjlf	534	23	partial	partial	JJ
cord-022313-2675sjlf	534	24	complex	complex	NN
cord-022313-2675sjlf	534	25	oligosac	oligosac	FW
cord-022313-2675sjlf	534	26	charide	charide	NN
cord-022313-2675sjlf	534	27	(	(	-LRB-
cord-022313-2675sjlf	534	28	i.e.	i.e.	FW
cord-022313-2675sjlf	534	29	,	,	,
cord-022313-2675sjlf	534	30	hybrid	hybrid	JJ
cord-022313-2675sjlf	534	31	chain	chain	NN
cord-022313-2675sjlf	534	32	)	)	-RRB-
cord-022313-2675sjlf	534	33	is	be	VBZ
cord-022313-2675sjlf	534	34	sufficient	sufficient	JJ
cord-022313-2675sjlf	534	35	for	for	IN
cord-022313-2675sjlf	534	36	functional	functional	JJ
cord-022313-2675sjlf	534	37	activity	activity	NN
cord-022313-2675sjlf	534	38	,	,	,
cord-022313-2675sjlf	534	39	at	at	IN
cord-022313-2675sjlf	534	40	least	least	JJS
cord-022313-2675sjlf	534	41	in	in	IN
cord-022313-2675sjlf	534	42	tissue	tissue	NN
cord-022313-2675sjlf	534	43	culture	culture	NN
cord-022313-2675sjlf	534	44	.	.	.
cord-022313-2675sjlf	535	1	For	for	IN
cord-022313-2675sjlf	535	2	example	example	NN
cord-022313-2675sjlf	535	3	,	,	,
cord-022313-2675sjlf	535	4	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	535	5	did	do	VBD
cord-022313-2675sjlf	535	6	not	not	RB
cord-022313-2675sjlf	535	7	impair	impair	VB
cord-022313-2675sjlf	535	8	the	the	DT
cord-022313-2675sjlf	535	9	synthesis	synthesis	NN
cord-022313-2675sjlf	535	10	or	or	CC
cord-022313-2675sjlf	535	11	export	export	NN
cord-022313-2675sjlf	535	12	of	of	IN
cord-022313-2675sjlf	535	13	thyroglobulin	thyroglobulin	NN
cord-022313-2675sjlf	535	14	in	in	IN
cord-022313-2675sjlf	535	15	porcine	porcine	JJ
cord-022313-2675sjlf	535	16	thyroid	thyroid	NN
cord-022313-2675sjlf	535	17	cells	cell	NNS
cord-022313-2675sjlf	535	18	(	(	-LRB-
cord-022313-2675sjlf	535	19	212	212	CD
cord-022313-2675sjlf	535	20	)	)	-RRB-
cord-022313-2675sjlf	535	21	,	,	,
cord-022313-2675sjlf	535	22	nor	nor	CC
cord-022313-2675sjlf	535	23	did	do	VBD
cord-022313-2675sjlf	535	24	it	-PRON-	PRP
cord-022313-2675sjlf	535	25	affect	affect	VB
cord-022313-2675sjlf	535	26	surfactant	surfactant	NN
cord-022313-2675sjlf	535	27	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	535	28	A	a	NN
cord-022313-2675sjlf	535	29	in	in	IN
cord-022313-2675sjlf	535	30	Type	Type	NNP
cord-022313-2675sjlf	535	31	II	II	NNP
cord-022313-2675sjlf	535	32	epithelial	epithelial	JJ
cord-022313-2675sjlf	535	33	cells	cell	NNS
cord-022313-2675sjlf	535	34	(	(	-LRB-
cord-022313-2675sjlf	535	35	213	213	CD
cord-022313-2675sjlf	535	36	)	)	-RRB-
cord-022313-2675sjlf	535	37	,	,	,
cord-022313-2675sjlf	535	38	H2-DK	H2-DK	NNP
cord-022313-2675sjlf	535	39	histocompatability	histocompatability	NN
cord-022313-2675sjlf	535	40	antigen	antigen	NN
cord-022313-2675sjlf	535	41	in	in	IN
cord-022313-2675sjlf	535	42	macrophages	macrophage	NNS
cord-022313-2675sjlf	535	43	(	(	-LRB-
cord-022313-2675sjlf	535	44	214	214	CD
cord-022313-2675sjlf	535	45	)	)	-RRB-
cord-022313-2675sjlf	535	46	,	,	,
cord-022313-2675sjlf	535	47	or	or	CC
cord-022313-2675sjlf	535	48	von	von	NNP
cord-022313-2675sjlf	535	49	Willebrand	Willebrand	NNP
cord-022313-2675sjlf	535	50	protein	protein	NN
cord-022313-2675sjlf	535	51	in	in	IN
cord-022313-2675sjlf	535	52	epithelial	epithelial	JJ
cord-022313-2675sjlf	535	53	cells	cell	NNS
cord-022313-2675sjlf	535	54	(	(	-LRB-
cord-022313-2675sjlf	535	55	215	215	CD
cord-022313-2675sjlf	535	56	)	)	-RRB-
cord-022313-2675sjlf	535	57	.	.	.
cord-022313-2675sjlf	536	1	It	-PRON-	PRP
cord-022313-2675sjlf	536	2	also	also	RB
cord-022313-2675sjlf	536	3	did	do	VBD
cord-022313-2675sjlf	536	4	not	not	RB
cord-022313-2675sjlf	536	5	affect	affect	VB
cord-022313-2675sjlf	536	6	the	the	DT
cord-022313-2675sjlf	536	7	targeting	targeting	NN
cord-022313-2675sjlf	536	8	or	or	CC
cord-022313-2675sjlf	536	9	function	function	NN
cord-022313-2675sjlf	536	10	of	of	IN
cord-022313-2675sjlf	536	11	various	various	JJ
cord-022313-2675sjlf	536	12	membrane	membrane	NN
cord-022313-2675sjlf	536	13	receptors	receptor	NNS
cord-022313-2675sjlf	536	14	,	,	,
cord-022313-2675sjlf	536	15	including	include	VBG
cord-022313-2675sjlf	536	16	insulin	insulin	NN
cord-022313-2675sjlf	536	17	receptor	receptor	NN
cord-022313-2675sjlf	536	18	(	(	-LRB-
cord-022313-2675sjlf	536	19	216	216	CD
cord-022313-2675sjlf	536	20	)	)	-RRB-
cord-022313-2675sjlf	536	21	,	,	,
cord-022313-2675sjlf	536	22	epidermal	epidermal	JJ
cord-022313-2675sjlf	536	23	growth	growth	NN
cord-022313-2675sjlf	536	24	factor	factor	NN
cord-022313-2675sjlf	536	25	receptor	receptor	NN
cord-022313-2675sjlf	536	26	(	(	-LRB-
cord-022313-2675sjlf	536	27	217	217	CD
cord-022313-2675sjlf	536	28	)	)	-RRB-
cord-022313-2675sjlf	536	29	,	,	,
cord-022313-2675sjlf	536	30	or	or	CC
cord-022313-2675sjlf	536	31	the	the	DT
cord-022313-2675sjlf	536	32	receptor	receptor	NN
cord-022313-2675sjlf	536	33	for	for	IN
cord-022313-2675sjlf	536	34	asialoglycoproteins	asialoglycoprotein	NNS
cord-022313-2675sjlf	536	35	(	(	-LRB-
cord-022313-2675sjlf	536	36	218	218	CD
cord-022313-2675sjlf	536	37	)	)	-RRB-
cord-022313-2675sjlf	536	38	.	.	.
cord-022313-2675sjlf	537	1	The	the	DT
cord-022313-2675sjlf	537	2	inhibitor	inhibitor	NN
cord-022313-2675sjlf	537	3	did	do	VBD
cord-022313-2675sjlf	537	4	,	,	,
cord-022313-2675sjlf	537	5	however	however	RB
cord-022313-2675sjlf	537	6	,	,	,
cord-022313-2675sjlf	537	7	block	block	VB
cord-022313-2675sjlf	537	8	the	the	DT
cord-022313-2675sjlf	537	9	receptormediated	receptormediate	VBN
cord-022313-2675sjlf	537	10	uptake	uptake	NN
cord-022313-2675sjlf	537	11	of	of	IN
cord-022313-2675sjlf	537	12	mannose	mannose	NN
cord-022313-2675sjlf	537	13	-	-	HYPH
cord-022313-2675sjlf	537	14	terminated	terminate	VBN
cord-022313-2675sjlf	537	15	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	537	16	by	by	IN
cord-022313-2675sjlf	537	17	macro	macro	JJ
cord-022313-2675sjlf	537	18	phages	phage	NNS
cord-022313-2675sjlf	537	19	.	.	.
cord-022313-2675sjlf	538	1	This	this	DT
cord-022313-2675sjlf	538	2	blockage	blockage	NN
cord-022313-2675sjlf	538	3	appeared	appear	VBD
cord-022313-2675sjlf	538	4	to	to	TO
cord-022313-2675sjlf	538	5	be	be	VB
cord-022313-2675sjlf	538	6	due	due	JJ
cord-022313-2675sjlf	538	7	to	to	IN
cord-022313-2675sjlf	538	8	the	the	DT
cord-022313-2675sjlf	538	9	formation	formation	NN
cord-022313-2675sjlf	538	10	of	of	IN
cord-022313-2675sjlf	538	11	hybrid	hybrid	JJ
cord-022313-2675sjlf	538	12	types	type	NNS
cord-022313-2675sjlf	538	13	of	of	IN
cord-022313-2675sjlf	538	14	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	538	15	on	on	IN
cord-022313-2675sjlf	538	16	the	the	DT
cord-022313-2675sjlf	538	17	macrophage	macrophage	NN
cord-022313-2675sjlf	538	18	surface	surface	NN
cord-022313-2675sjlf	538	19	,	,	,
cord-022313-2675sjlf	538	20	which	which	WDT
cord-022313-2675sjlf	538	21	then	then	RB
cord-022313-2675sjlf	538	22	reacted	react	VBD
cord-022313-2675sjlf	538	23	with	with	IN
cord-022313-2675sjlf	538	24	and	and	CC
cord-022313-2675sjlf	538	25	bound	bind	VBD
cord-022313-2675sjlf	538	26	the	the	DT
cord-022313-2675sjlf	538	27	mannose	mannose	NN
cord-022313-2675sjlf	538	28	receptors	receptor	NNS
cord-022313-2675sjlf	538	29	(	(	-LRB-
cord-022313-2675sjlf	538	30	219	219	CD
cord-022313-2675sjlf	538	31	)	)	-RRB-
cord-022313-2675sjlf	538	32	.	.	.
cord-022313-2675sjlf	539	1	Swainsonine	Swainsonine	NNP
cord-022313-2675sjlf	539	2	proved	prove	VBD
cord-022313-2675sjlf	539	3	to	to	TO
cord-022313-2675sjlf	539	4	be	be	VB
cord-022313-2675sjlf	539	5	useful	useful	JJ
cord-022313-2675sjlf	539	6	in	in	IN
cord-022313-2675sjlf	539	7	demonstrating	demonstrate	VBG
cord-022313-2675sjlf	539	8	the	the	DT
cord-022313-2675sjlf	539	9	sequence	sequence	NN
cord-022313-2675sjlf	539	10	of	of	IN
cord-022313-2675sjlf	539	11	addition	addition	NN
cord-022313-2675sjlf	539	12	of	of	IN
cord-022313-2675sjlf	539	13	the	the	DT
cord-022313-2675sjlf	539	14	various	various	JJ
cord-022313-2675sjlf	539	15	sugars	sugar	NNS
cord-022313-2675sjlf	539	16	in	in	IN
cord-022313-2675sjlf	539	17	the	the	DT
cord-022313-2675sjlf	539	18	N	n	NN
cord-022313-2675sjlf	539	19	-	-	HYPH
cord-022313-2675sjlf	539	20	linked	link	VBN
cord-022313-2675sjlf	539	21	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	539	22	assembly	assembly	NN
cord-022313-2675sjlf	539	23	pathway	pathway	NN
cord-022313-2675sjlf	539	24	.	.	.
cord-022313-2675sjlf	540	1	Thus	thus	RB
cord-022313-2675sjlf	540	2	,	,	,
cord-022313-2675sjlf	540	3	when	when	WRB
cord-022313-2675sjlf	540	4	fucosylation	fucosylation	NN
cord-022313-2675sjlf	540	5	(	(	-LRB-
cord-022313-2675sjlf	540	6	220	220	CD
cord-022313-2675sjlf	540	7	)	)	-RRB-
cord-022313-2675sjlf	540	8	and	and	CC
cord-022313-2675sjlf	540	9	sulfation	sulfation	NN
cord-022313-2675sjlf	540	10	(	(	-LRB-
cord-022313-2675sjlf	540	11	221	221	CD
cord-022313-2675sjlf	540	12	)	)	-RRB-
cord-022313-2675sjlf	540	13	of	of	IN
cord-022313-2675sjlf	540	14	the	the	DT
cord-022313-2675sjlf	540	15	influenza	influenza	NN
cord-022313-2675sjlf	540	16	viral	viral	JJ
cord-022313-2675sjlf	540	17	hemaggluti	hemaggluti	NNP
cord-022313-2675sjlf	540	18	nin	nin	NNP
cord-022313-2675sjlf	540	19	was	be	VBD
cord-022313-2675sjlf	540	20	examined	examine	VBN
cord-022313-2675sjlf	540	21	in	in	IN
cord-022313-2675sjlf	540	22	cells	cell	NNS
cord-022313-2675sjlf	540	23	grown	grow	VBN
cord-022313-2675sjlf	540	24	in	in	IN
cord-022313-2675sjlf	540	25	the	the	DT
cord-022313-2675sjlf	540	26	presence	presence	NN
cord-022313-2675sjlf	540	27	of	of	IN
cord-022313-2675sjlf	540	28	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	540	29	or	or	CC
cord-022313-2675sjlf	540	30	castanospermine	castanospermine	NN
cord-022313-2675sjlf	540	31	,	,	,
cord-022313-2675sjlf	540	32	it	-PRON-	PRP
cord-022313-2675sjlf	540	33	was	be	VBD
cord-022313-2675sjlf	540	34	found	find	VBN
cord-022313-2675sjlf	540	35	that	that	IN
cord-022313-2675sjlf	540	36	the	the	DT
cord-022313-2675sjlf	540	37	hemagglutinin	hemagglutinin	NN
cord-022313-2675sjlf	540	38	did	do	VBD
cord-022313-2675sjlf	540	39	contain	contain	VB
cord-022313-2675sjlf	540	40	[	[	-LRB-
cord-022313-2675sjlf	540	41	3	3	CD
cord-022313-2675sjlf	540	42	H]fucose	H]fucose	NNP
cord-022313-2675sjlf	540	43	and	and	CC
cord-022313-2675sjlf	540	44	[	[	-LRB-
cord-022313-2675sjlf	540	45	35	35	CD
cord-022313-2675sjlf	540	46	S]sulfate	S]sulfate	NNP
cord-022313-2675sjlf	540	47	when	when	WRB
cord-022313-2675sjlf	540	48	the	the	DT
cord-022313-2675sjlf	540	49	virus	virus	NN
cord-022313-2675sjlf	540	50	was	be	VBD
cord-022313-2675sjlf	540	51	raised	raise	VBN
cord-022313-2675sjlf	540	52	in	in	IN
cord-022313-2675sjlf	540	53	the	the	DT
cord-022313-2675sjlf	540	54	presence	presence	NN
cord-022313-2675sjlf	540	55	of	of	IN
cord-022313-2675sjlf	540	56	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	540	57	,	,	,
cord-022313-2675sjlf	540	58	but	but	CC
cord-022313-2675sjlf	540	59	not	not	RB
cord-022313-2675sjlf	540	60	when	when	WRB
cord-022313-2675sjlf	540	61	virus	virus	NN
cord-022313-2675sjlf	540	62	was	be	VBD
cord-022313-2675sjlf	540	63	produced	produce	VBN
cord-022313-2675sjlf	540	64	in	in	IN
cord-022313-2675sjlf	540	65	the	the	DT
cord-022313-2675sjlf	540	66	presence	presence	NN
cord-022313-2675sjlf	540	67	of	of	IN
cord-022313-2675sjlf	540	68	castanospermine	castanospermine	NN
cord-022313-2675sjlf	540	69	(	(	-LRB-
cord-022313-2675sjlf	540	70	or	or	CC
cord-022313-2675sjlf	540	71	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	540	72	)	)	-RRB-
cord-022313-2675sjlf	540	73	.	.	.
cord-022313-2675sjlf	541	1	These	these	DT
cord-022313-2675sjlf	541	2	studies	study	NNS
cord-022313-2675sjlf	541	3	suggest	suggest	VBP
cord-022313-2675sjlf	541	4	that	that	IN
cord-022313-2675sjlf	541	5	the	the	DT
cord-022313-2675sjlf	541	6	fucosyltransferase	fucosyltransferase	NN
cord-022313-2675sjlf	541	7	and	and	CC
cord-022313-2675sjlf	541	8	the	the	DT
cord-022313-2675sjlf	541	9	sulfotransferase	sulfotransferase	NNP
cord-022313-2675sjlf	541	10	recognize	recognize	VB
cord-022313-2675sjlf	541	11	the	the	DT
cord-022313-2675sjlf	541	12	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	541	13	-	-	HYPH
cord-022313-2675sjlf	541	14	Man	Man	NNP
cord-022313-2675sjlf	541	15	5	5	CD
cord-022313-2675sjlf	541	16	(	(	-LRB-
cord-022313-2675sjlf	541	17	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	541	18	)	)	-RRB-
cord-022313-2675sjlf	541	19	2	2	CD
cord-022313-2675sjlf	541	20	structure	structure	NN
cord-022313-2675sjlf	541	21	as	as	IN
cord-022313-2675sjlf	541	22	the	the	DT
cord-022313-2675sjlf	541	23	appropriate	appropriate	JJ
cord-022313-2675sjlf	541	24	acceptor	acceptor	NN
cord-022313-2675sjlf	541	25	sub	sub	NN
cord-022313-2675sjlf	541	26	strate	strate	NNP
cord-022313-2675sjlf	541	27	.	.	.
cord-022313-2675sjlf	542	1	Some	some	DT
cord-022313-2675sjlf	542	2	proteins	protein	NNS
cord-022313-2675sjlf	542	3	do	do	VBP
cord-022313-2675sjlf	542	4	show	show	VB
cord-022313-2675sjlf	542	5	a	a	DT
cord-022313-2675sjlf	542	6	loss	loss	NN
cord-022313-2675sjlf	542	7	of	of	IN
cord-022313-2675sjlf	542	8	function	function	NN
cord-022313-2675sjlf	542	9	when	when	WRB
cord-022313-2675sjlf	542	10	they	-PRON-	PRP
cord-022313-2675sjlf	542	11	are	be	VBP
cord-022313-2675sjlf	542	12	produced	produce	VBN
cord-022313-2675sjlf	542	13	in	in	IN
cord-022313-2675sjlf	542	14	the	the	DT
cord-022313-2675sjlf	542	15	presence	presence	NN
cord-022313-2675sjlf	542	16	of	of	IN
cord-022313-2675sjlf	542	17	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	542	18	.	.	.
cord-022313-2675sjlf	543	1	Thus	thus	RB
cord-022313-2675sjlf	543	2	,	,	,
cord-022313-2675sjlf	543	3	the	the	DT
cord-022313-2675sjlf	543	4	glucocorticoid	glucocorticoid	JJ
cord-022313-2675sjlf	543	5	stimulation	stimulation	NN
cord-022313-2675sjlf	543	6	of	of	IN
cord-022313-2675sjlf	543	7	resorptive	resorptive	JJ
cord-022313-2675sjlf	543	8	cells	cell	NNS
cord-022313-2675sjlf	543	9	,	,	,
cord-022313-2675sjlf	543	10	which	which	WDT
cord-022313-2675sjlf	543	11	appears	appear	VBZ
cord-022313-2675sjlf	543	12	to	to	TO
cord-022313-2675sjlf	543	13	involve	involve	VB
cord-022313-2675sjlf	543	14	the	the	DT
cord-022313-2675sjlf	543	15	attachment	attachment	NN
cord-022313-2675sjlf	543	16	of	of	IN
cord-022313-2675sjlf	543	17	osteoblasts	osteoblast	NNS
cord-022313-2675sjlf	543	18	and	and	CC
cord-022313-2675sjlf	543	19	related	related	JJ
cord-022313-2675sjlf	543	20	cells	cell	NNS
cord-022313-2675sjlf	543	21	to	to	IN
cord-022313-2675sjlf	543	22	bone	bone	NN
cord-022313-2675sjlf	543	23	,	,	,
cord-022313-2675sjlf	543	24	is	be	VBZ
cord-022313-2675sjlf	543	25	inhibited	inhibit	VBN
cord-022313-2675sjlf	543	26	or	or	CC
cord-022313-2675sjlf	543	27	blocked	block	VBN
cord-022313-2675sjlf	543	28	by	by	IN
cord-022313-2675sjlf	543	29	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	543	30	(	(	-LRB-
cord-022313-2675sjlf	543	31	222	222	CD
cord-022313-2675sjlf	543	32	)	)	-RRB-
cord-022313-2675sjlf	543	33	.	.	.
cord-022313-2675sjlf	544	1	This	this	DT
cord-022313-2675sjlf	544	2	drug	drug	NN
cord-022313-2675sjlf	544	3	also	also	RB
cord-022313-2675sjlf	544	4	reduced	reduce	VBD
cord-022313-2675sjlf	544	5	the	the	DT
cord-022313-2675sjlf	544	6	interaction	interaction	NN
cord-022313-2675sjlf	544	7	of	of	IN
cord-022313-2675sjlf	544	8	Tyrpanosoma	Tyrpanosoma	NNP
cord-022313-2675sjlf	544	9	cruzi	cruzi	NNP
cord-022313-2675sjlf	544	10	with	with	IN
cord-022313-2675sjlf	544	11	peri	peri	NNP
cord-022313-2675sjlf	544	12	toneal	toneal	NN
cord-022313-2675sjlf	544	13	macrophages	macrophage	NNS
cord-022313-2675sjlf	544	14	when	when	WRB
cord-022313-2675sjlf	544	15	either	either	CC
cord-022313-2675sjlf	544	16	the	the	DT
cord-022313-2675sjlf	544	17	host	host	NN
cord-022313-2675sjlf	544	18	cells	cell	NNS
cord-022313-2675sjlf	544	19	or	or	CC
cord-022313-2675sjlf	544	20	the	the	DT
cord-022313-2675sjlf	544	21	parasites	parasite	NNS
cord-022313-2675sjlf	544	22	were	be	VBD
cord-022313-2675sjlf	544	23	treated	treat	VBN
cord-022313-2675sjlf	544	24	with	with	IN
cord-022313-2675sjlf	544	25	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	544	26	(	(	-LRB-
cord-022313-2675sjlf	544	27	223	223	CD
cord-022313-2675sjlf	544	28	)	)	-RRB-
cord-022313-2675sjlf	544	29	.	.	.
cord-022313-2675sjlf	545	1	Also	also	RB
cord-022313-2675sjlf	545	2	a	a	DT
cord-022313-2675sjlf	545	3	dramatic	dramatic	JJ
cord-022313-2675sjlf	545	4	decline	decline	NN
cord-022313-2675sjlf	545	5	in	in	IN
cord-022313-2675sjlf	545	6	the	the	DT
cord-022313-2675sjlf	545	7	ability	ability	NN
cord-022313-2675sjlf	545	8	of	of	IN
cord-022313-2675sjlf	545	9	B16	B16	NNP
cord-022313-2675sjlf	545	10	melanoma	melanoma	NN
cord-022313-2675sjlf	545	11	cells	cell	NNS
cord-022313-2675sjlf	545	12	to	to	TO
cord-022313-2675sjlf	545	13	colonize	colonize	VB
cord-022313-2675sjlf	545	14	the	the	DT
cord-022313-2675sjlf	545	15	lungs	lung	NNS
cord-022313-2675sjlf	545	16	of	of	IN
cord-022313-2675sjlf	545	17	experimental	experimental	JJ
cord-022313-2675sjlf	545	18	animals	animal	NNS
cord-022313-2675sjlf	545	19	was	be	VBD
cord-022313-2675sjlf	545	20	observed	observe	VBN
cord-022313-2675sjlf	545	21	when	when	WRB
cord-022313-2675sjlf	545	22	the	the	DT
cord-022313-2675sjlf	545	23	cells	cell	NNS
cord-022313-2675sjlf	545	24	were	be	VBD
cord-022313-2675sjlf	545	25	incubated	incubate	VBN
cord-022313-2675sjlf	545	26	in	in	IN
cord-022313-2675sjlf	545	27	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	545	28	(	(	-LRB-
cord-022313-2675sjlf	545	29	224	224	CD
cord-022313-2675sjlf	545	30	)	)	-RRB-
cord-022313-2675sjlf	545	31	.	.	.
cord-022313-2675sjlf	546	1	Treatment	treatment	NN
cord-022313-2675sjlf	546	2	of	of	IN
cord-022313-2675sjlf	546	3	lymphocytes	lymphocyte	NNS
cord-022313-2675sjlf	546	4	with	with	IN
cord-022313-2675sjlf	546	5	the	the	DT
cord-022313-2675sjlf	546	6	mitogen	mitogen	NNP
cord-022313-2675sjlf	546	7	concanavalin	concanavalin	NNP
cord-022313-2675sjlf	547	1	A	a	DT
cord-022313-2675sjlf	547	2	stimulates	stimulate	VBZ
cord-022313-2675sjlf	547	3	them	-PRON-	PRP
cord-022313-2675sjlf	547	4	to	to	TO
cord-022313-2675sjlf	547	5	proliferate	proliferate	VB
cord-022313-2675sjlf	547	6	,	,	,
cord-022313-2675sjlf	547	7	but	but	CC
cord-022313-2675sjlf	547	8	this	this	DT
cord-022313-2675sjlf	547	9	proliferation	proliferation	NN
cord-022313-2675sjlf	547	10	can	can	MD
cord-022313-2675sjlf	547	11	be	be	VB
cord-022313-2675sjlf	547	12	blocked	block	VBN
cord-022313-2675sjlf	547	13	by	by	IN
cord-022313-2675sjlf	547	14	an	an	DT
cord-022313-2675sjlf	547	15	immunosuppresive	immunosuppresive	JJ
cord-022313-2675sjlf	547	16	factor	factor	NN
cord-022313-2675sjlf	547	17	found	find	VBN
cord-022313-2675sjlf	547	18	in	in	IN
cord-022313-2675sjlf	547	19	the	the	DT
cord-022313-2675sjlf	547	20	serum	serum	NN
cord-022313-2675sjlf	547	21	of	of	IN
cord-022313-2675sjlf	547	22	mice	mouse	NNS
cord-022313-2675sjlf	547	23	that	that	WDT
cord-022313-2675sjlf	547	24	contain	contain	VBP
cord-022313-2675sjlf	547	25	the	the	DT
cord-022313-2675sjlf	547	26	tumor	tumor	NN
cord-022313-2675sjlf	547	27	sarcoma	sarcoma	NN
cord-022313-2675sjlf	547	28	180	180	CD
cord-022313-2675sjlf	547	29	.	.	.
cord-022313-2675sjlf	548	1	The	the	DT
cord-022313-2675sjlf	548	2	suppression	suppression	NN
cord-022313-2675sjlf	548	3	caused	cause	VBN
cord-022313-2675sjlf	548	4	by	by	IN
cord-022313-2675sjlf	548	5	this	this	DT
cord-022313-2675sjlf	548	6	factor	factor	NN
cord-022313-2675sjlf	548	7	is	be	VBZ
cord-022313-2675sjlf	548	8	somehow	somehow	RB
cord-022313-2675sjlf	548	9	over	over	IN
cord-022313-2675sjlf	548	10	come	come	VBN
cord-022313-2675sjlf	548	11	by	by	IN
cord-022313-2675sjlf	548	12	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	548	13	,	,	,
cord-022313-2675sjlf	548	14	indicating	indicate	VBG
cord-022313-2675sjlf	548	15	that	that	IN
cord-022313-2675sjlf	548	16	this	this	DT
cord-022313-2675sjlf	548	17	alkaloid	alkaloid	NN
cord-022313-2675sjlf	548	18	might	may	MD
cord-022313-2675sjlf	548	19	have	have	VB
cord-022313-2675sjlf	548	20	some	some	DT
cord-022313-2675sjlf	548	21	chemotherapeutic	chemotherapeutic	JJ
cord-022313-2675sjlf	548	22	value	value	NN
cord-022313-2675sjlf	548	23	in	in	IN
cord-022313-2675sjlf	548	24	immunosuppressive	immunosuppressive	JJ
cord-022313-2675sjlf	548	25	diseases	disease	NNS
cord-022313-2675sjlf	548	26	(	(	-LRB-
cord-022313-2675sjlf	548	27	225	225	CD
cord-022313-2675sjlf	548	28	)	)	-RRB-
cord-022313-2675sjlf	548	29	.	.	.
cord-022313-2675sjlf	549	1	The	the	DT
cord-022313-2675sjlf	549	2	turnover	turnover	NN
cord-022313-2675sjlf	549	3	or	or	CC
cord-022313-2675sjlf	549	4	degradation	degradation	NN
cord-022313-2675sjlf	549	5	of	of	IN
cord-022313-2675sjlf	549	6	endocytosed	endocytose	VBN
cord-022313-2675sjlf	549	7	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	549	8	is	be	VBZ
cord-022313-2675sjlf	549	9	also	also	RB
cord-022313-2675sjlf	549	10	inhibited	inhibit	VBN
cord-022313-2675sjlf	549	11	by	by	IN
cord-022313-2675sjlf	549	12	swainsonine	swainsonine	NN
cord-022313-2675sjlf	549	13	and	and	CC
cord-022313-2675sjlf	549	14	this	this	DT
cord-022313-2675sjlf	549	15	leads	lead	VBZ
cord-022313-2675sjlf	549	16	to	to	IN
cord-022313-2675sjlf	549	17	the	the	DT
cord-022313-2675sjlf	549	18	accumulation	accumulation	NN
cord-022313-2675sjlf	549	19	of	of	IN
cord-022313-2675sjlf	549	20	these	these	DT
cord-022313-2675sjlf	549	21	glycopro	glycopro	NNP
cord-022313-2675sjlf	549	22	teins	tein	NNS
cord-022313-2675sjlf	549	23	in	in	IN
cord-022313-2675sjlf	549	24	the	the	DT
cord-022313-2675sjlf	549	25	lysosomes	lysosome	NNS
cord-022313-2675sjlf	549	26	of	of	IN
cord-022313-2675sjlf	549	27	tissue	tissue	NN
cord-022313-2675sjlf	549	28	culture	culture	NN
cord-022313-2675sjlf	549	29	cells	cell	NNS
cord-022313-2675sjlf	549	30	incubated	incubate	VBN
cord-022313-2675sjlf	549	31	with	with	IN
cord-022313-2675sjlf	549	32	this	this	DT
cord-022313-2675sjlf	549	33	drug	drug	NN
cord-022313-2675sjlf	549	34	.	.	.
cord-022313-2675sjlf	550	1	The	the	DT
cord-022313-2675sjlf	550	2	block	block	NN
cord-022313-2675sjlf	550	3	here	here	RB
cord-022313-2675sjlf	550	4	appears	appear	VBZ
cord-022313-2675sjlf	550	5	to	to	TO
cord-022313-2675sjlf	550	6	be	be	VB
cord-022313-2675sjlf	550	7	due	due	JJ
cord-022313-2675sjlf	550	8	to	to	IN
cord-022313-2675sjlf	550	9	the	the	DT
cord-022313-2675sjlf	550	10	inhibition	inhibition	NN
cord-022313-2675sjlf	550	11	of	of	IN
cord-022313-2675sjlf	550	12	lysosomal	lysosomal	JJ
cord-022313-2675sjlf	550	13	mannosi	mannosi	NNP
cord-022313-2675sjlf	550	14	dase	dase	NNP
cord-022313-2675sjlf	550	15	(	(	-LRB-
cord-022313-2675sjlf	550	16	and	and	CC
cord-022313-2675sjlf	550	17	perhaps	perhaps	RB
cord-022313-2675sjlf	550	18	other	other	JJ
cord-022313-2675sjlf	550	19	enzymes	enzyme	NNS
cord-022313-2675sjlf	550	20	)	)	-RRB-
cord-022313-2675sjlf	550	21	,	,	,
cord-022313-2675sjlf	550	22	indicating	indicate	VBG
cord-022313-2675sjlf	550	23	that	that	IN
cord-022313-2675sjlf	550	24	the	the	DT
cord-022313-2675sjlf	550	25	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	550	26	portion	portion	NN
cord-022313-2675sjlf	550	27	of	of	IN
cord-022313-2675sjlf	550	28	these	these	DT
cord-022313-2675sjlf	550	29	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	550	30	must	must	MD
cord-022313-2675sjlf	550	31	be	be	VB
cord-022313-2675sjlf	550	32	degraded	degrade	VBN
cord-022313-2675sjlf	550	33	before	before	IN
cord-022313-2675sjlf	550	34	the	the	DT
cord-022313-2675sjlf	550	35	protein	protein	NN
cord-022313-2675sjlf	550	36	(	(	-LRB-
cord-022313-2675sjlf	550	37	226	226	CD
cord-022313-2675sjlf	550	38	)	)	-RRB-
cord-022313-2675sjlf	550	39	.	.	.
cord-022313-2675sjlf	551	1	All	all	DT
cord-022313-2675sjlf	551	2	of	of	IN
cord-022313-2675sjlf	551	3	these	these	DT
cord-022313-2675sjlf	551	4	studies	study	NNS
cord-022313-2675sjlf	551	5	suggest	suggest	VBP
cord-022313-2675sjlf	551	6	that	that	IN
cord-022313-2675sjlf	551	7	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	551	8	may	may	MD
cord-022313-2675sjlf	551	9	have	have	VB
cord-022313-2675sjlf	551	10	important	important	JJ
cord-022313-2675sjlf	551	11	effects	effect	NNS
cord-022313-2675sjlf	551	12	on	on	IN
cord-022313-2675sjlf	551	13	some	some	DT
cord-022313-2675sjlf	551	14	cell	cell	NN
cord-022313-2675sjlf	551	15	systems	system	NNS
cord-022313-2675sjlf	551	16	and	and	CC
cord-022313-2675sjlf	551	17	therefore	therefore	RB
cord-022313-2675sjlf	551	18	it	-PRON-	PRP
cord-022313-2675sjlf	551	19	or	or	CC
cord-022313-2675sjlf	551	20	some	some	DT
cord-022313-2675sjlf	551	21	related	related	JJ
cord-022313-2675sjlf	551	22	compounds	compound	NNS
cord-022313-2675sjlf	551	23	may	may	MD
cord-022313-2675sjlf	551	24	have	have	VB
cord-022313-2675sjlf	551	25	some	some	DT
cord-022313-2675sjlf	551	26	chemotherapeutic	chemotherapeutic	JJ
cord-022313-2675sjlf	551	27	value	value	NN
cord-022313-2675sjlf	551	28	.	.	.
cord-022313-2675sjlf	552	1	However	however	RB
cord-022313-2675sjlf	552	2	,	,	,
cord-022313-2675sjlf	552	3	additional	additional	JJ
cord-022313-2675sjlf	552	4	studies	study	NNS
cord-022313-2675sjlf	552	5	will	will	MD
cord-022313-2675sjlf	552	6	be	be	VB
cord-022313-2675sjlf	552	7	required	require	VBN
cord-022313-2675sjlf	552	8	with	with	IN
cord-022313-2675sjlf	552	9	these	these	DT
cord-022313-2675sjlf	552	10	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	552	11	.	.	.
cord-022313-2675sjlf	553	1	Another	another	DT
cord-022313-2675sjlf	553	2	inhibitor	inhibitor	NN
cord-022313-2675sjlf	553	3	of	of	IN
cord-022313-2675sjlf	553	4	mannosidase	mannosidase	NN
cord-022313-2675sjlf	553	5	II	II	NNP
cord-022313-2675sjlf	553	6	that	that	WDT
cord-022313-2675sjlf	553	7	was	be	VBD
cord-022313-2675sjlf	553	8	recently	recently	RB
cord-022313-2675sjlf	553	9	isolated	isolate	VBN
cord-022313-2675sjlf	553	10	from	from	IN
cord-022313-2675sjlf	553	11	a	a	DT
cord-022313-2675sjlf	553	12	fungus	fungus	NN
cord-022313-2675sjlf	553	13	is	be	VBZ
cord-022313-2675sjlf	553	14	called	call	VBN
cord-022313-2675sjlf	553	15	mannostatin	mannostatin	NNP
cord-022313-2675sjlf	553	16	(	(	-LRB-
cord-022313-2675sjlf	553	17	227	227	CD
cord-022313-2675sjlf	553	18	)	)	-RRB-
cord-022313-2675sjlf	553	19	.	.	.
cord-022313-2675sjlf	554	1	This	this	DT
cord-022313-2675sjlf	554	2	compound	compound	NN
cord-022313-2675sjlf	554	3	is	be	VBZ
cord-022313-2675sjlf	554	4	interesting	interesting	JJ
cord-022313-2675sjlf	554	5	because	because	IN
cord-022313-2675sjlf	554	6	it	-PRON-	PRP
cord-022313-2675sjlf	554	7	is	be	VBZ
cord-022313-2675sjlf	554	8	the	the	DT
cord-022313-2675sjlf	554	9	only	only	JJ
cord-022313-2675sjlf	554	10	one	one	CD
cord-022313-2675sjlf	554	11	of	of	IN
cord-022313-2675sjlf	554	12	these	these	DT
cord-022313-2675sjlf	554	13	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	554	14	presently	presently	RB
cord-022313-2675sjlf	554	15	known	know	VBN
cord-022313-2675sjlf	554	16	that	that	WDT
cord-022313-2675sjlf	554	17	has	have	VBZ
cord-022313-2675sjlf	554	18	an	an	DT
cord-022313-2675sjlf	554	19	exocyclic	exocyclic	JJ
cord-022313-2675sjlf	554	20	nitrogen	nitrogen	NN
cord-022313-2675sjlf	554	21	rather	rather	RB
cord-022313-2675sjlf	554	22	than	than	IN
cord-022313-2675sjlf	554	23	a	a	DT
cord-022313-2675sjlf	554	24	nitrogen	nitrogen	NN
cord-022313-2675sjlf	554	25	in	in	IN
cord-022313-2675sjlf	554	26	the	the	DT
cord-022313-2675sjlf	554	27	ring	ring	NN
cord-022313-2675sjlf	554	28	.	.	.
cord-022313-2675sjlf	555	1	In	in	IN
cord-022313-2675sjlf	555	2	addition	addition	NN
cord-022313-2675sjlf	555	3	,	,	,
cord-022313-2675sjlf	555	4	as	as	IN
cord-022313-2675sjlf	555	5	seen	see	VBN
cord-022313-2675sjlf	555	6	in	in	IN
cord-022313-2675sjlf	555	7	Fig	Fig	NNP
cord-022313-2675sjlf	555	8	.	.	.
cord-022313-2675sjlf	556	1	10	10	CD
cord-022313-2675sjlf	556	2	,	,	,
cord-022313-2675sjlf	556	3	mannostatin	mannostatin	NNP
cord-022313-2675sjlf	556	4	has	have	VBZ
cord-022313-2675sjlf	556	5	a	a	DT
cord-022313-2675sjlf	556	6	thiomethyl	thiomethyl	NN
cord-022313-2675sjlf	556	7	group	group	NN
cord-022313-2675sjlf	556	8	and	and	CC
cord-022313-2675sjlf	556	9	a	a	DT
cord-022313-2675sjlf	556	10	fivemembered	fivemembered	JJ
cord-022313-2675sjlf	556	11	ring	ring	NN
cord-022313-2675sjlf	556	12	.	.	.
cord-022313-2675sjlf	557	1	Mannostatin	Mannostatin	NNP
cord-022313-2675sjlf	557	2	was	be	VBD
cord-022313-2675sjlf	557	3	found	find	VBN
cord-022313-2675sjlf	557	4	to	to	TO
cord-022313-2675sjlf	557	5	be	be	VB
cord-022313-2675sjlf	557	6	a	a	DT
cord-022313-2675sjlf	557	7	potent	potent	JJ
cord-022313-2675sjlf	557	8	inhibitor	inhibitor	NN
cord-022313-2675sjlf	557	9	of	of	IN
cord-022313-2675sjlf	557	10	mannosidase	mannosidase	NN
cord-022313-2675sjlf	557	11	II	II	NNP
cord-022313-2675sjlf	558	1	(	(	-LRB-
cord-022313-2675sjlf	558	2	IC	IC	NNP
cord-022313-2675sjlf	558	3	50	50	CD
cord-022313-2675sjlf	558	4	=	=	SYM
cord-022313-2675sjlf	558	5	100	100	CD
cord-022313-2675sjlf	558	6	nM	nM	NNP
cord-022313-2675sjlf	558	7	)	)	-RRB-
cord-022313-2675sjlf	558	8	and	and	CC
cord-022313-2675sjlf	558	9	jack	jack	NNP
cord-022313-2675sjlf	558	10	bean	bean	NNP
cord-022313-2675sjlf	558	11	mannosidase	mannosidase	NNP
cord-022313-2675sjlf	558	12	.	.	.
cord-022313-2675sjlf	559	1	In	in	IN
cord-022313-2675sjlf	559	2	cell	cell	NN
cord-022313-2675sjlf	559	3	culture	culture	NN
cord-022313-2675sjlf	559	4	studies	study	NNS
cord-022313-2675sjlf	559	5	,	,	,
cord-022313-2675sjlf	559	6	mannostatin	mannostatin	NNP
cord-022313-2675sjlf	559	7	gave	give	VBD
cord-022313-2675sjlf	559	8	rise	rise	NN
cord-022313-2675sjlf	559	9	to	to	IN
cord-022313-2675sjlf	559	10	the	the	DT
cord-022313-2675sjlf	559	11	same	same	JJ
cord-022313-2675sjlf	559	12	types	type	NNS
cord-022313-2675sjlf	559	13	of	of	IN
cord-022313-2675sjlf	559	14	hybrid	hybrid	JJ
cord-022313-2675sjlf	559	15	structures	structure	NNS
cord-022313-2675sjlf	559	16	that	that	WDT
cord-022313-2675sjlf	559	17	are	be	VBP
cord-022313-2675sjlf	559	18	observed	observe	VBN
cord-022313-2675sjlf	559	19	in	in	IN
cord-022313-2675sjlf	559	20	cells	cell	NNS
cord-022313-2675sjlf	559	21	incubated	incubate	VBN
cord-022313-2675sjlf	559	22	in	in	IN
cord-022313-2675sjlf	559	23	the	the	DT
cord-022313-2675sjlf	559	24	presence	presence	NN
cord-022313-2675sjlf	559	25	of	of	IN
cord-022313-2675sjlf	559	26	swasinsonine	swasinsonine	NNP
cord-022313-2675sjlf	559	27	(	(	-LRB-
cord-022313-2675sjlf	559	28	228	228	CD
cord-022313-2675sjlf	559	29	)	)	-RRB-
cord-022313-2675sjlf	559	30	.	.	.
cord-022313-2675sjlf	560	1	However	however	RB
cord-022313-2675sjlf	560	2	,	,	,
cord-022313-2675sjlf	560	3	the	the	DT
cord-022313-2675sjlf	560	4	N	n	CD
cord-022313-2675sjlf	560	5	-	-	HYPH
cord-022313-2675sjlf	560	6	acetylated	acetylated	JJ
cord-022313-2675sjlf	560	7	derivative	derivative	NN
cord-022313-2675sjlf	560	8	of	of	IN
cord-022313-2675sjlf	560	9	mannostatin	mannostatin	NNP
cord-022313-2675sjlf	560	10	was	be	VBD
cord-022313-2675sjlf	560	11	inactive	inactive	JJ
cord-022313-2675sjlf	560	12	against	against	IN
cord-022313-2675sjlf	560	13	any	any	DT
cord-022313-2675sjlf	560	14	of	of	IN
cord-022313-2675sjlf	560	15	the	the	DT
cord-022313-2675sjlf	560	16	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	560	17	.	.	.
cord-022313-2675sjlf	561	1	Although	although	IN
cord-022313-2675sjlf	561	2	mannostatin	mannostatin	NNP
cord-022313-2675sjlf	561	3	is	be	VBZ
cord-022313-2675sjlf	561	4	not	not	RB
cord-022313-2675sjlf	561	5	any	any	RB
cord-022313-2675sjlf	561	6	different	different	JJ
cord-022313-2675sjlf	561	7	in	in	IN
cord-022313-2675sjlf	561	8	its	-PRON-	PRP$
cord-022313-2675sjlf	561	9	site	site	NN
cord-022313-2675sjlf	561	10	of	of	IN
cord-022313-2675sjlf	561	11	action	action	NN
cord-022313-2675sjlf	561	12	,	,	,
cord-022313-2675sjlf	561	13	or	or	CC
cord-022313-2675sjlf	561	14	any	any	DT
cord-022313-2675sjlf	561	15	more	more	RBR
cord-022313-2675sjlf	561	16	active	active	JJ
cord-022313-2675sjlf	561	17	than	than	IN
cord-022313-2675sjlf	561	18	swain	swain	NNP
cord-022313-2675sjlf	561	19	sonine	sonine	NNP
cord-022313-2675sjlf	561	20	,	,	,
cord-022313-2675sjlf	561	21	it	-PRON-	PRP
cord-022313-2675sjlf	561	22	is	be	VBZ
cord-022313-2675sjlf	561	23	an	an	DT
cord-022313-2675sjlf	561	24	interesting	interesting	JJ
cord-022313-2675sjlf	561	25	addition	addition	NN
cord-022313-2675sjlf	561	26	to	to	IN
cord-022313-2675sjlf	561	27	the	the	DT
cord-022313-2675sjlf	561	28	repertoire	repertoire	NN
cord-022313-2675sjlf	561	29	of	of	IN
cord-022313-2675sjlf	561	30	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	561	31	be	be	VB
cord-022313-2675sjlf	561	32	cause	cause	IN
cord-022313-2675sjlf	561	33	it	-PRON-	PRP
cord-022313-2675sjlf	561	34	shows	show	VBZ
cord-022313-2675sjlf	561	35	a	a	DT
cord-022313-2675sjlf	561	36	heretofore	heretofore	RB
cord-022313-2675sjlf	561	37	unanticipated	unanticipated	JJ
cord-022313-2675sjlf	561	38	structure	structure	NN
cord-022313-2675sjlf	561	39	as	as	IN
cord-022313-2675sjlf	561	40	a	a	DT
cord-022313-2675sjlf	561	41	glycosidase	glycosidase	JJ
cord-022313-2675sjlf	561	42	inhibitor	inhibitor	NN
cord-022313-2675sjlf	561	43	.	.	.
cord-022313-2675sjlf	562	1	This	this	DT
cord-022313-2675sjlf	562	2	opens	open	VBZ
cord-022313-2675sjlf	562	3	up	up	RP
cord-022313-2675sjlf	562	4	a	a	DT
cord-022313-2675sjlf	562	5	number	number	NN
cord-022313-2675sjlf	562	6	of	of	IN
cord-022313-2675sjlf	562	7	new	new	JJ
cord-022313-2675sjlf	562	8	possibilities	possibility	NNS
cord-022313-2675sjlf	562	9	for	for	IN
cord-022313-2675sjlf	562	10	chemical	chemical	JJ
cord-022313-2675sjlf	562	11	synthesis	synthesis	NN
cord-022313-2675sjlf	562	12	of	of	IN
cord-022313-2675sjlf	562	13	related	related	JJ
cord-022313-2675sjlf	562	14	structures	structure	NNS
cord-022313-2675sjlf	562	15	or	or	CC
cord-022313-2675sjlf	562	16	perhaps	perhaps	RB
cord-022313-2675sjlf	562	17	structures	structure	NNS
cord-022313-2675sjlf	562	18	that	that	WDT
cord-022313-2675sjlf	562	19	combine	combine	VBP
cord-022313-2675sjlf	562	20	some	some	DT
cord-022313-2675sjlf	562	21	aspects	aspect	NNS
cord-022313-2675sjlf	562	22	of	of	IN
cord-022313-2675sjlf	562	23	mannostatin	mannostatin	NNP
cord-022313-2675sjlf	562	24	and	and	CC
cord-022313-2675sjlf	562	25	some	some	DT
cord-022313-2675sjlf	562	26	aspects	aspect	NNS
cord-022313-2675sjlf	562	27	of	of	IN
cord-022313-2675sjlf	562	28	other	other	JJ
cord-022313-2675sjlf	562	29	alkaloids	alkaloid	NNS
cord-022313-2675sjlf	562	30	.	.	.
cord-022313-2675sjlf	563	1	A	a	DT
cord-022313-2675sjlf	563	2	number	number	NN
cord-022313-2675sjlf	563	3	of	of	IN
cord-022313-2675sjlf	563	4	laboratories	laboratory	NNS
cord-022313-2675sjlf	563	5	have	have	VBP
cord-022313-2675sjlf	563	6	been	be	VBN
cord-022313-2675sjlf	563	7	developing	develop	VBG
cord-022313-2675sjlf	563	8	methods	method	NNS
cord-022313-2675sjlf	563	9	for	for	IN
cord-022313-2675sjlf	563	10	the	the	DT
cord-022313-2675sjlf	563	11	syn	syn	NN
cord-022313-2675sjlf	563	12	thesis	thesis	NN
cord-022313-2675sjlf	563	13	of	of	IN
cord-022313-2675sjlf	563	14	the	the	DT
cord-022313-2675sjlf	563	15	above	above	JJ
cord-022313-2675sjlf	563	16	alkaloids	alkaloid	NNS
cord-022313-2675sjlf	563	17	or	or	CC
cord-022313-2675sjlf	563	18	their	-PRON-	PRP$
cord-022313-2675sjlf	563	19	derivatives	derivative	NNS
cord-022313-2675sjlf	563	20	,	,	,
cord-022313-2675sjlf	563	21	as	as	RB
cord-022313-2675sjlf	563	22	well	well	RB
cord-022313-2675sjlf	563	23	as	as	IN
cord-022313-2675sjlf	563	24	of	of	IN
cord-022313-2675sjlf	563	25	other	other	JJ
cord-022313-2675sjlf	563	26	new	new	JJ
cord-022313-2675sjlf	563	27	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	563	28	(	(	-LRB-
cord-022313-2675sjlf	563	29	229	229	CD
cord-022313-2675sjlf	563	30	)	)	-RRB-
cord-022313-2675sjlf	563	31	.	.	.
cord-022313-2675sjlf	564	1	So	so	RB
cord-022313-2675sjlf	564	2	far	far	RB
cord-022313-2675sjlf	564	3	,	,	,
cord-022313-2675sjlf	564	4	with	with	IN
cord-022313-2675sjlf	564	5	the	the	DT
cord-022313-2675sjlf	564	6	exception	exception	NN
cord-022313-2675sjlf	564	7	of	of	IN
cord-022313-2675sjlf	564	8	mannostatin	mannostatin	NNP
cord-022313-2675sjlf	564	9	,	,	,
cord-022313-2675sjlf	564	10	all	all	DT
cord-022313-2675sjlf	564	11	of	of	IN
cord-022313-2675sjlf	564	12	the	the	DT
cord-022313-2675sjlf	564	13	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	564	14	have	have	VBP
cord-022313-2675sjlf	564	15	had	have	VBN
cord-022313-2675sjlf	564	16	a	a	DT
cord-022313-2675sjlf	564	17	nitrogen	nitrogen	NN
cord-022313-2675sjlf	564	18	in	in	IN
cord-022313-2675sjlf	564	19	the	the	DT
cord-022313-2675sjlf	564	20	ring	ring	NN
cord-022313-2675sjlf	564	21	in	in	IN
cord-022313-2675sjlf	564	22	place	place	NN
cord-022313-2675sjlf	564	23	of	of	IN
cord-022313-2675sjlf	564	24	the	the	DT
cord-022313-2675sjlf	564	25	oxygen	oxygen	NN
cord-022313-2675sjlf	564	26	,	,	,
cord-022313-2675sjlf	564	27	and	and	CC
cord-022313-2675sjlf	564	28	at	at	RB
cord-022313-2675sjlf	564	29	least	least	RBS
cord-022313-2675sjlf	564	30	three	three	CD
cord-022313-2675sjlf	564	31	assy	assy	NN
cord-022313-2675sjlf	564	32	metric	metric	JJ
cord-022313-2675sjlf	564	33	hydroxy	hydroxy	NN
cord-022313-2675sjlf	564	34	1	1	CD
cord-022313-2675sjlf	564	35	groups	group	NNS
cord-022313-2675sjlf	564	36	.	.	.
cord-022313-2675sjlf	565	1	The	the	DT
cord-022313-2675sjlf	565	2	substitution	substitution	NN
cord-022313-2675sjlf	565	3	of	of	IN
cord-022313-2675sjlf	565	4	the	the	DT
cord-022313-2675sjlf	565	5	ring	ring	NN
cord-022313-2675sjlf	565	6	oxygen	oxygen	NN
cord-022313-2675sjlf	565	7	by	by	IN
cord-022313-2675sjlf	565	8	a	a	DT
cord-022313-2675sjlf	565	9	nitrogen	nitrogen	NN
cord-022313-2675sjlf	565	10	apparantly	apparantly	RB
cord-022313-2675sjlf	565	11	renders	render	VBZ
cord-022313-2675sjlf	565	12	the	the	DT
cord-022313-2675sjlf	565	13	compound	compound	NN
cord-022313-2675sjlf	565	14	metabolically	metabolically	RB
cord-022313-2675sjlf	565	15	inert	inert	JJ
cord-022313-2675sjlf	565	16	but	but	CC
cord-022313-2675sjlf	565	17	does	do	VBZ
cord-022313-2675sjlf	565	18	not	not	RB
cord-022313-2675sjlf	565	19	prevent	prevent	VB
cord-022313-2675sjlf	565	20	the	the	DT
cord-022313-2675sjlf	565	21	recognition	recognition	NN
cord-022313-2675sjlf	565	22	of	of	IN
cord-022313-2675sjlf	565	23	the	the	DT
cord-022313-2675sjlf	565	24	compound	compound	NN
cord-022313-2675sjlf	565	25	by	by	IN
cord-022313-2675sjlf	565	26	glycosidases	glycosidase	NNS
cord-022313-2675sjlf	565	27	or	or	CC
cord-022313-2675sjlf	565	28	perhaps	perhaps	RB
cord-022313-2675sjlf	565	29	by	by	IN
cord-022313-2675sjlf	565	30	other	other	JJ
cord-022313-2675sjlf	565	31	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	565	32	recognizing	recognize	VBG
cord-022313-2675sjlf	565	33	enzymes	enzyme	NNS
cord-022313-2675sjlf	565	34	.	.	.
cord-022313-2675sjlf	566	1	Presumably	presumably	RB
cord-022313-2675sjlf	566	2	the	the	DT
cord-022313-2675sjlf	566	3	hydroxyl	hydroxyl	NN
cord-022313-2675sjlf	566	4	groups	group	NNS
cord-022313-2675sjlf	566	5	in	in	IN
cord-022313-2675sjlf	566	6	these	these	DT
cord-022313-2675sjlf	566	7	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	566	8	have	have	VBP
cord-022313-2675sjlf	566	9	the	the	DT
cord-022313-2675sjlf	566	10	same	same	JJ
cord-022313-2675sjlf	566	11	chirality	chirality	NN
cord-022313-2675sjlf	566	12	as	as	IN
cord-022313-2675sjlf	566	13	the	the	DT
cord-022313-2675sjlf	566	14	sugar	sugar	NN
cord-022313-2675sjlf	566	15	that	that	WDT
cord-022313-2675sjlf	566	16	is	be	VBZ
cord-022313-2675sjlf	566	17	a	a	DT
cord-022313-2675sjlf	566	18	substrate	substrate	NN
cord-022313-2675sjlf	566	19	for	for	IN
cord-022313-2675sjlf	566	20	the	the	DT
cord-022313-2675sjlf	566	21	glycosidase	glycosidase	NN
cord-022313-2675sjlf	566	22	to	to	TO
cord-022313-2675sjlf	566	23	be	be	VB
cord-022313-2675sjlf	566	24	inhibited	inhibit	VBN
cord-022313-2675sjlf	566	25	.	.	.
cord-022313-2675sjlf	567	1	Interestingly	interestingly	RB
cord-022313-2675sjlf	567	2	enough	enough	RB
cord-022313-2675sjlf	567	3	,	,	,
cord-022313-2675sjlf	567	4	these	these	DT
cord-022313-2675sjlf	567	5	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	567	6	do	do	VBP
cord-022313-2675sjlf	567	7	not	not	RB
cord-022313-2675sjlf	567	8	necessarily	necessarily	RB
cord-022313-2675sjlf	567	9	need	need	VB
cord-022313-2675sjlf	567	10	to	to	TO
cord-022313-2675sjlf	567	11	have	have	VB
cord-022313-2675sjlf	567	12	a	a	DT
cord-022313-2675sjlf	567	13	six	six	CD
cord-022313-2675sjlf	567	14	-	-	HYPH
cord-022313-2675sjlf	567	15	membered	membered	JJ
cord-022313-2675sjlf	567	16	ring	ring	NN
cord-022313-2675sjlf	567	17	structure	structure	NN
cord-022313-2675sjlf	567	18	to	to	TO
cord-022313-2675sjlf	567	19	mimic	mimic	VB
cord-022313-2675sjlf	567	20	the	the	DT
cord-022313-2675sjlf	567	21	catalytic	catalytic	JJ
cord-022313-2675sjlf	567	22	intermediate	intermediate	NN
cord-022313-2675sjlf	567	23	that	that	WDT
cord-022313-2675sjlf	567	24	is	be	VBZ
cord-022313-2675sjlf	567	25	involved	involve	VBN
cord-022313-2675sjlf	567	26	in	in	IN
cord-022313-2675sjlf	567	27	the	the	DT
cord-022313-2675sjlf	567	28	substrate	substrate	NN
cord-022313-2675sjlf	567	29	recognition	recognition	NN
cord-022313-2675sjlf	567	30	or	or	CC
cord-022313-2675sjlf	567	31	hydrolytic	hydrolytic	JJ
cord-022313-2675sjlf	567	32	step	step	NN
cord-022313-2675sjlf	567	33	.	.	.
cord-022313-2675sjlf	568	1	In	in	IN
cord-022313-2675sjlf	568	2	fact	fact	NN
cord-022313-2675sjlf	568	3	,	,	,
cord-022313-2675sjlf	568	4	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	568	5	best	good	JJS
cord-022313-2675sjlf	568	6	fits	fit	VBZ
cord-022313-2675sjlf	568	7	as	as	IN
cord-022313-2675sjlf	568	8	a	a	DT
cord-022313-2675sjlf	568	9	mannose	mannose	NN
cord-022313-2675sjlf	568	10	analog	analog	NN
cord-022313-2675sjlf	568	11	when	when	WRB
cord-022313-2675sjlf	568	12	it	-PRON-	PRP
cord-022313-2675sjlf	568	13	is	be	VBZ
cord-022313-2675sjlf	568	14	in	in	IN
cord-022313-2675sjlf	568	15	a	a	DT
cord-022313-2675sjlf	568	16	staggered	staggered	JJ
cord-022313-2675sjlf	568	17	or	or	CC
cord-022313-2675sjlf	568	18	half	half	JJ
cord-022313-2675sjlf	568	19	-	-	HYPH
cord-022313-2675sjlf	568	20	chair	chair	NN
cord-022313-2675sjlf	568	21	conformation	conformation	NN
cord-022313-2675sjlf	568	22	(	(	-LRB-
cord-022313-2675sjlf	568	23	203	203	CD
cord-022313-2675sjlf	568	24	)	)	-RRB-
cord-022313-2675sjlf	568	25	,	,	,
cord-022313-2675sjlf	568	26	and	and	CC
cord-022313-2675sjlf	568	27	other	other	JJ
cord-022313-2675sjlf	568	28	pyrrolidine	pyrrolidine	JJ
cord-022313-2675sjlf	568	29	or	or	CC
cord-022313-2675sjlf	568	30	pyrrolizidine	pyrrolizidine	JJ
cord-022313-2675sjlf	568	31	ring	ring	NN
cord-022313-2675sjlf	568	32	structures	structure	NNS
cord-022313-2675sjlf	568	33	may	may	MD
cord-022313-2675sjlf	568	34	also	also	RB
cord-022313-2675sjlf	568	35	assume	assume	VB
cord-022313-2675sjlf	568	36	similar	similar	JJ
cord-022313-2675sjlf	568	37	conformations	conformation	NNS
cord-022313-2675sjlf	568	38	.	.	.
cord-022313-2675sjlf	569	1	Molecular	molecular	JJ
cord-022313-2675sjlf	569	2	modeling	modeling	NN
cord-022313-2675sjlf	569	3	studies	study	NNS
cord-022313-2675sjlf	569	4	with	with	IN
cord-022313-2675sjlf	569	5	these	these	DT
cord-022313-2675sjlf	569	6	compounds	compound	NNS
cord-022313-2675sjlf	569	7	will	will	MD
cord-022313-2675sjlf	569	8	help	help	VB
cord-022313-2675sjlf	569	9	to	to	IN
cord-022313-2675sjlf	569	10	under	under	IN
cord-022313-2675sjlf	569	11	stand	stand	VB
cord-022313-2675sjlf	569	12	the	the	DT
cord-022313-2675sjlf	569	13	mechanism	mechanism	NN
cord-022313-2675sjlf	569	14	of	of	IN
cord-022313-2675sjlf	569	15	inhibition	inhibition	NN
cord-022313-2675sjlf	569	16	by	by	IN
cord-022313-2675sjlf	569	17	some	some	DT
cord-022313-2675sjlf	569	18	of	of	IN
cord-022313-2675sjlf	569	19	these	these	DT
cord-022313-2675sjlf	569	20	compounds	compound	NNS
cord-022313-2675sjlf	569	21	.	.	.
cord-022313-2675sjlf	570	1	Such	such	JJ
cord-022313-2675sjlf	570	2	modeling	modeling	NN
cord-022313-2675sjlf	570	3	studies	study	NNS
cord-022313-2675sjlf	570	4	have	have	VBP
cord-022313-2675sjlf	570	5	been	be	VBN
cord-022313-2675sjlf	570	6	done	do	VBN
cord-022313-2675sjlf	570	7	with	with	IN
cord-022313-2675sjlf	570	8	some	some	DT
cord-022313-2675sjlf	570	9	of	of	IN
cord-022313-2675sjlf	570	10	the	the	DT
cord-022313-2675sjlf	570	11	mannosidase	mannosidase	NNP
cord-022313-2675sjlf	570	12	inhibi	inhibi	NNP
cord-022313-2675sjlf	570	13	tors	tor	NNS
cord-022313-2675sjlf	570	14	compared	compare	VBN
cord-022313-2675sjlf	570	15	with	with	IN
cord-022313-2675sjlf	570	16	the	the	DT
cord-022313-2675sjlf	570	17	mannopyranosyl	mannopyranosyl	NNP
cord-022313-2675sjlf	570	18	cation	cation	NN
cord-022313-2675sjlf	570	19	as	as	IN
cord-022313-2675sjlf	570	20	the	the	DT
cord-022313-2675sjlf	570	21	active	active	JJ
cord-022313-2675sjlf	570	22	intermedi	intermedi	NNP
cord-022313-2675sjlf	570	23	ate	eat	VBD
cord-022313-2675sjlf	570	24	of	of	IN
cord-022313-2675sjlf	570	25	jack	jack	NNP
cord-022313-2675sjlf	570	26	bean	bean	NNP
cord-022313-2675sjlf	570	27	mannosidase	mannosidase	NNP
cord-022313-2675sjlf	570	28	(	(	-LRB-
cord-022313-2675sjlf	570	29	230	230	CD
cord-022313-2675sjlf	570	30	)	)	-RRB-
cord-022313-2675sjlf	570	31	.	.	.
cord-022313-2675sjlf	571	1	However	however	RB
cord-022313-2675sjlf	571	2	,	,	,
cord-022313-2675sjlf	571	3	the	the	DT
cord-022313-2675sjlf	571	4	synthesis	synthesis	NN
cord-022313-2675sjlf	571	5	or	or	CC
cord-022313-2675sjlf	571	6	isolation	isolation	NN
cord-022313-2675sjlf	571	7	of	of	IN
cord-022313-2675sjlf	571	8	other	other	JJ
cord-022313-2675sjlf	571	9	and	and	CC
cord-022313-2675sjlf	571	10	different	different	JJ
cord-022313-2675sjlf	571	11	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	571	12	of	of	IN
cord-022313-2675sjlf	571	13	these	these	DT
cord-022313-2675sjlf	571	14	enzymes	enzyme	NNS
cord-022313-2675sjlf	571	15	will	will	MD
cord-022313-2675sjlf	571	16	add	add	VB
cord-022313-2675sjlf	571	17	to	to	IN
cord-022313-2675sjlf	571	18	this	this	DT
cord-022313-2675sjlf	571	19	infor	infor	FW
cord-022313-2675sjlf	571	20	mation	mation	NN
cord-022313-2675sjlf	571	21	.	.	.
cord-022313-2675sjlf	572	1	The	the	DT
cord-022313-2675sjlf	572	2	synthesis	synthesis	NN
cord-022313-2675sjlf	572	3	of	of	IN
cord-022313-2675sjlf	572	4	lipid	lipid	NN
cord-022313-2675sjlf	572	5	-	-	HYPH
cord-022313-2675sjlf	572	6	linked	link	VBN
cord-022313-2675sjlf	572	7	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	572	8	in	in	IN
cord-022313-2675sjlf	572	9	animal	animal	NN
cord-022313-2675sjlf	572	10	tissues	tissue	NNS
cord-022313-2675sjlf	572	11	or	or	CC
cord-022313-2675sjlf	572	12	by	by	IN
cord-022313-2675sjlf	572	13	cultured	cultured	JJ
cord-022313-2675sjlf	572	14	animal	animal	NN
cord-022313-2675sjlf	572	15	cells	cell	NNS
cord-022313-2675sjlf	572	16	has	have	VBZ
cord-022313-2675sjlf	572	17	been	be	VBN
cord-022313-2675sjlf	572	18	shown	show	VBN
cord-022313-2675sjlf	572	19	to	to	TO
cord-022313-2675sjlf	572	20	be	be	VB
cord-022313-2675sjlf	572	21	inhibited	inhibit	VBN
cord-022313-2675sjlf	572	22	by	by	IN
cord-022313-2675sjlf	572	23	several	several	JJ
cord-022313-2675sjlf	572	24	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	572	25	of	of	IN
cord-022313-2675sjlf	572	26	protein	protein	NN
cord-022313-2675sjlf	572	27	synthesis	synthesis	NN
cord-022313-2675sjlf	572	28	(	(	-LRB-
cord-022313-2675sjlf	572	29	231	231	CD
cord-022313-2675sjlf	572	30	)	)	-RRB-
cord-022313-2675sjlf	572	31	.	.	.
cord-022313-2675sjlf	573	1	For	for	IN
cord-022313-2675sjlf	573	2	example	example	NN
cord-022313-2675sjlf	573	3	,	,	,
cord-022313-2675sjlf	573	4	when	when	WRB
cord-022313-2675sjlf	573	5	MDCK	MDCK	NNP
cord-022313-2675sjlf	573	6	cells	cell	NNS
cord-022313-2675sjlf	573	7	were	be	VBD
cord-022313-2675sjlf	573	8	grown	grow	VBN
cord-022313-2675sjlf	573	9	in	in	IN
cord-022313-2675sjlf	573	10	the	the	DT
cord-022313-2675sjlf	573	11	presence	presence	NN
cord-022313-2675sjlf	573	12	of	of	IN
cord-022313-2675sjlf	573	13	cycloheximide	cycloheximide	NN
cord-022313-2675sjlf	573	14	or	or	CC
cord-022313-2675sjlf	573	15	puromycin	puromycin	NNS
cord-022313-2675sjlf	573	16	,	,	,
cord-022313-2675sjlf	573	17	both	both	DT
cord-022313-2675sjlf	573	18	in	in	IN
cord-022313-2675sjlf	573	19	hibitors	hibitor	NNS
cord-022313-2675sjlf	573	20	of	of	IN
cord-022313-2675sjlf	573	21	protein	protein	NN
cord-022313-2675sjlf	573	22	synthesis	synthesis	NN
cord-022313-2675sjlf	573	23	but	but	CC
cord-022313-2675sjlf	573	24	by	by	IN
cord-022313-2675sjlf	573	25	different	different	JJ
cord-022313-2675sjlf	573	26	mechanisms	mechanism	NNS
cord-022313-2675sjlf	573	27	,	,	,
cord-022313-2675sjlf	573	28	there	there	EX
cord-022313-2675sjlf	573	29	was	be	VBD
cord-022313-2675sjlf	573	30	a	a	DT
cord-022313-2675sjlf	573	31	dose	dose	NN
cord-022313-2675sjlf	573	32	-	-	HYPH
cord-022313-2675sjlf	573	33	dependent	dependent	JJ
cord-022313-2675sjlf	573	34	inhibition	inhibition	NN
cord-022313-2675sjlf	573	35	in	in	IN
cord-022313-2675sjlf	573	36	the	the	DT
cord-022313-2675sjlf	573	37	incorporation	incorporation	NN
cord-022313-2675sjlf	573	38	of	of	IN
cord-022313-2675sjlf	573	39	[	[	-LRB-
cord-022313-2675sjlf	573	40	2	2	CD
cord-022313-2675sjlf	573	41	-	-	SYM
cord-022313-2675sjlf	573	42	3	3	CD
cord-022313-2675sjlf	573	43	H]mannose	H]mannose	NNP
cord-022313-2675sjlf	573	44	into	into	IN
cord-022313-2675sjlf	573	45	the	the	DT
cord-022313-2675sjlf	573	46	lipid	lipid	NN
cord-022313-2675sjlf	573	47	-	-	HYPH
cord-022313-2675sjlf	573	48	linked	link	VBN
cord-022313-2675sjlf	573	49	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	573	50	.	.	.
cord-022313-2675sjlf	574	1	However	however	RB
cord-022313-2675sjlf	574	2	,	,	,
cord-022313-2675sjlf	574	3	these	these	DT
cord-022313-2675sjlf	574	4	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	574	5	did	do	VBD
cord-022313-2675sjlf	574	6	not	not	RB
cord-022313-2675sjlf	574	7	affect	affect	VB
cord-022313-2675sjlf	574	8	mannose	mannose	JJ
cord-022313-2675sjlf	574	9	incorporation	incorporation	NN
cord-022313-2675sjlf	574	10	into	into	IN
cord-022313-2675sjlf	574	11	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	574	12	-	-	HYPH
cord-022313-2675sjlf	574	13	P	p	NN
cord-022313-2675sjlf	574	14	-	-	HYPH
cord-022313-2675sjlf	574	15	mannose	mannose	NN
cord-022313-2675sjlf	574	16	,	,	,
cord-022313-2675sjlf	574	17	nor	nor	CC
cord-022313-2675sjlf	574	18	did	do	VBD
cord-022313-2675sjlf	574	19	they	-PRON-	PRP
cord-022313-2675sjlf	574	20	block	block	VB
cord-022313-2675sjlf	574	21	mannose	mannose	NN
cord-022313-2675sjlf	574	22	incorporation	incorporation	NN
cord-022313-2675sjlf	574	23	from	from	IN
cord-022313-2675sjlf	574	24	GDP-	GDP-	NNP
cord-022313-2675sjlf	574	25	[	[	-LRB-
cord-022313-2675sjlf	574	26	14	14	CD
cord-022313-2675sjlf	574	27	C]mannose	C]mannose	NNP
cord-022313-2675sjlf	574	28	into	into	IN
cord-022313-2675sjlf	574	29	lipid	lipid	NN
cord-022313-2675sjlf	574	30	-	-	HYPH
cord-022313-2675sjlf	574	31	linked	link	VBN
cord-022313-2675sjlf	574	32	saccharides	saccharide	NNS
cord-022313-2675sjlf	574	33	in	in	IN
cord-022313-2675sjlf	574	34	cell	cell	NN
cord-022313-2675sjlf	574	35	-	-	HYPH
cord-022313-2675sjlf	574	36	free	free	JJ
cord-022313-2675sjlf	574	37	extracts	extract	NNS
cord-022313-2675sjlf	574	38	prepared	prepare	VBN
cord-022313-2675sjlf	574	39	from	from	IN
cord-022313-2675sjlf	574	40	MDCK	MDCK	NNP
cord-022313-2675sjlf	574	41	cells	cell	NNS
cord-022313-2675sjlf	574	42	or	or	CC
cord-022313-2675sjlf	574	43	from	from	IN
cord-022313-2675sjlf	574	44	porcine	porcine	JJ
cord-022313-2675sjlf	574	45	aorta	aorta	NN
cord-022313-2675sjlf	574	46	.	.	.
cord-022313-2675sjlf	575	1	These	these	DT
cord-022313-2675sjlf	575	2	results	result	NNS
cord-022313-2675sjlf	575	3	could	could	MD
cord-022313-2675sjlf	575	4	be	be	VB
cord-022313-2675sjlf	575	5	explained	explain	VBN
cord-022313-2675sjlf	575	6	by	by	IN
cord-022313-2675sjlf	575	7	one	one	CD
cord-022313-2675sjlf	575	8	of	of	IN
cord-022313-2675sjlf	575	9	the	the	DT
cord-022313-2675sjlf	575	10	following	follow	VBG
cord-022313-2675sjlf	575	11	postulations	postulation	NNS
cord-022313-2675sjlf	575	12	:	:	:
cord-022313-2675sjlf	575	13	(	(	-LRB-
cord-022313-2675sjlf	575	14	a	a	LS
cord-022313-2675sjlf	575	15	)	)	-RRB-
cord-022313-2675sjlf	575	16	limitation	limitation	NN
cord-022313-2675sjlf	575	17	in	in	IN
cord-022313-2675sjlf	575	18	the	the	DT
cord-022313-2675sjlf	575	19	amount	amount	NN
cord-022313-2675sjlf	575	20	of	of	IN
cord-022313-2675sjlf	575	21	dolichyl	dolichyl	NN
cord-022313-2675sjlf	575	22	-	-	HYPH
cord-022313-2675sjlf	575	23	P	p	NN
cord-022313-2675sjlf	575	24	available	available	JJ
cord-022313-2675sjlf	575	25	to	to	TO
cord-022313-2675sjlf	575	26	serve	serve	VB
cord-022313-2675sjlf	575	27	as	as	IN
cord-022313-2675sjlf	575	28	a	a	DT
cord-022313-2675sjlf	575	29	carrier	carrier	NN
cord-022313-2675sjlf	575	30	of	of	IN
cord-022313-2675sjlf	575	31	the	the	DT
cord-022313-2675sjlf	575	32	sugars	sugar	NNS
cord-022313-2675sjlf	575	33	or	or	CC
cord-022313-2675sjlf	575	34	(	(	-LRB-
cord-022313-2675sjlf	575	35	b	b	LS
cord-022313-2675sjlf	575	36	)	)	-RRB-
cord-022313-2675sjlf	575	37	feedback	feedback	VB
cord-022313-2675sjlf	575	38	inhibition	inhibition	NN
cord-022313-2675sjlf	575	39	in	in	IN
cord-022313-2675sjlf	575	40	the	the	DT
cord-022313-2675sjlf	575	41	synthesis	synthesis	NN
cord-022313-2675sjlf	575	42	of	of	IN
cord-022313-2675sjlf	575	43	lipid	lipid	NN
cord-022313-2675sjlf	575	44	-	-	HYPH
cord-022313-2675sjlf	575	45	linked	link	VBN
cord-022313-2675sjlf	575	46	saccharides	saccharide	NNS
cord-022313-2675sjlf	575	47	caused	cause	VBN
cord-022313-2675sjlf	575	48	by	by	IN
cord-022313-2675sjlf	575	49	the	the	DT
cord-022313-2675sjlf	575	50	accumulation	accumulation	NN
cord-022313-2675sjlf	575	51	of	of	IN
cord-022313-2675sjlf	575	52	lipid	lipid	NN
cord-022313-2675sjlf	575	53	-	-	HYPH
cord-022313-2675sjlf	575	54	linked	link	VBN
cord-022313-2675sjlf	575	55	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	575	56	resulting	result	VBG
cord-022313-2675sjlf	575	57	from	from	IN
cord-022313-2675sjlf	575	58	lack	lack	NN
cord-022313-2675sjlf	575	59	of	of	IN
cord-022313-2675sjlf	575	60	acceptor	acceptor	NN
cord-022313-2675sjlf	575	61	protein	protein	NN
cord-022313-2675sjlf	575	62	.	.	.
cord-022313-2675sjlf	576	1	However	however	RB
cord-022313-2675sjlf	576	2	,	,	,
cord-022313-2675sjlf	576	3	since	since	IN
cord-022313-2675sjlf	576	4	the	the	DT
cord-022313-2675sjlf	576	5	synthesis	synthesis	NN
cord-022313-2675sjlf	576	6	of	of	IN
cord-022313-2675sjlf	576	7	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	576	8	-	-	HYPH
cord-022313-2675sjlf	576	9	P	p	NN
cord-022313-2675sjlf	576	10	-	-	HYPH
cord-022313-2675sjlf	576	11	mannose	mannose	NN
cord-022313-2675sjlf	576	12	was	be	VBD
cord-022313-2675sjlf	576	13	not	not	RB
cord-022313-2675sjlf	576	14	inhibited	inhibit	VBN
cord-022313-2675sjlf	576	15	,	,	,
cord-022313-2675sjlf	576	16	the	the	DT
cord-022313-2675sjlf	576	17	feedback	feedback	NN
cord-022313-2675sjlf	576	18	mechanism	mechanism	NN
cord-022313-2675sjlf	576	19	seemed	seem	VBD
cord-022313-2675sjlf	576	20	more	more	RBR
cord-022313-2675sjlf	576	21	likely	likely	JJ
cord-022313-2675sjlf	576	22	(	(	-LRB-
cord-022313-2675sjlf	576	23	232	232	CD
cord-022313-2675sjlf	576	24	)	)	-RRB-
cord-022313-2675sjlf	576	25	.	.	.
cord-022313-2675sjlf	577	1	Additional	additional	JJ
cord-022313-2675sjlf	577	2	studies	study	NNS
cord-022313-2675sjlf	577	3	showed	show	VBD
cord-022313-2675sjlf	577	4	that	that	IN
cord-022313-2675sjlf	577	5	the	the	DT
cord-022313-2675sjlf	577	6	inhibition	inhibition	NN
cord-022313-2675sjlf	577	7	by	by	IN
cord-022313-2675sjlf	577	8	cycloheximide	cycloheximide	NN
cord-022313-2675sjlf	577	9	could	could	MD
cord-022313-2675sjlf	577	10	not	not	RB
cord-022313-2675sjlf	577	11	be	be	VB
cord-022313-2675sjlf	577	12	overcome	overcome	VBN
cord-022313-2675sjlf	577	13	by	by	IN
cord-022313-2675sjlf	577	14	adding	add	VBG
cord-022313-2675sjlf	577	15	exogenous	exogenous	JJ
cord-022313-2675sjlf	577	16	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	577	17	-	-	HYPH
cord-022313-2675sjlf	577	18	P	p	NN
cord-022313-2675sjlf	577	19	,	,	,
cord-022313-2675sjlf	577	20	even	even	RB
cord-022313-2675sjlf	577	21	though	though	IN
cord-022313-2675sjlf	577	22	addition	addition	NN
cord-022313-2675sjlf	577	23	of	of	IN
cord-022313-2675sjlf	577	24	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	577	25	-	-	HYPH
cord-022313-2675sjlf	577	26	P	p	NN
cord-022313-2675sjlf	577	27	to	to	IN
cord-022313-2675sjlf	577	28	normal	normal	JJ
cord-022313-2675sjlf	577	29	cells	cell	NNS
cord-022313-2675sjlf	577	30	did	do	VBD
cord-022313-2675sjlf	577	31	stimulate	stimulate	VB
cord-022313-2675sjlf	577	32	the	the	DT
cord-022313-2675sjlf	577	33	incorporation	incorporation	NN
cord-022313-2675sjlf	577	34	of	of	IN
cord-022313-2675sjlf	577	35	mannose	mannose	NN
cord-022313-2675sjlf	577	36	into	into	IN
cord-022313-2675sjlf	577	37	lipid	lipid	NN
cord-022313-2675sjlf	577	38	-	-	HYPH
cord-022313-2675sjlf	577	39	linked	link	VBN
cord-022313-2675sjlf	577	40	saccharides	saccharide	NNS
cord-022313-2675sjlf	577	41	.	.	.
cord-022313-2675sjlf	578	1	However	however	RB
cord-022313-2675sjlf	578	2	,	,	,
cord-022313-2675sjlf	578	3	the	the	DT
cord-022313-2675sjlf	578	4	specific	specific	JJ
cord-022313-2675sjlf	578	5	site	site	NN
cord-022313-2675sjlf	578	6	of	of	IN
cord-022313-2675sjlf	578	7	inhibition	inhibition	NN
cord-022313-2675sjlf	578	8	(	(	-LRB-
cord-022313-2675sjlf	578	9	or	or	CC
cord-022313-2675sjlf	578	10	feedback	feedback	NN
cord-022313-2675sjlf	578	11	inhibition	inhibition	NN
cord-022313-2675sjlf	578	12	)	)	-RRB-
cord-022313-2675sjlf	578	13	by	by	IN
cord-022313-2675sjlf	578	14	these	these	DT
cord-022313-2675sjlf	578	15	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	578	16	is	be	VBZ
cord-022313-2675sjlf	578	17	not	not	RB
cord-022313-2675sjlf	578	18	known	know	VBN
cord-022313-2675sjlf	578	19	.	.	.
cord-022313-2675sjlf	579	1	Actinomycin	Actinomycin	NNP
cord-022313-2675sjlf	579	2	,	,	,
cord-022313-2675sjlf	579	3	an	an	DT
cord-022313-2675sjlf	579	4	inhibitor	inhibitor	NN
cord-022313-2675sjlf	579	5	of	of	IN
cord-022313-2675sjlf	579	6	RNA	RNA	NNP
cord-022313-2675sjlf	579	7	synthesis	synthesis	NN
cord-022313-2675sjlf	579	8	,	,	,
cord-022313-2675sjlf	579	9	was	be	VBD
cord-022313-2675sjlf	579	10	also	also	RB
cord-022313-2675sjlf	579	11	found	find	VBN
cord-022313-2675sjlf	579	12	to	to	TO
cord-022313-2675sjlf	579	13	inhibit	inhibit	VB
cord-022313-2675sjlf	579	14	the	the	DT
cord-022313-2675sjlf	579	15	incorpora	incorpora	NNP
cord-022313-2675sjlf	579	16	tion	tion	NN
cord-022313-2675sjlf	579	17	of	of	IN
cord-022313-2675sjlf	579	18	mannose	mannose	NN
cord-022313-2675sjlf	579	19	into	into	IN
cord-022313-2675sjlf	579	20	lipid	lipid	NN
cord-022313-2675sjlf	579	21	-	-	HYPH
cord-022313-2675sjlf	579	22	linked	link	VBN
cord-022313-2675sjlf	579	23	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	579	24	,	,	,
cord-022313-2675sjlf	579	25	but	but	CC
cord-022313-2675sjlf	579	26	again	again	RB
cord-022313-2675sjlf	579	27	the	the	DT
cord-022313-2675sjlf	579	28	exact	exact	JJ
cord-022313-2675sjlf	579	29	site	site	NN
cord-022313-2675sjlf	579	30	of	of	IN
cord-022313-2675sjlf	579	31	inhibition	inhibition	NN
cord-022313-2675sjlf	579	32	was	be	VBD
cord-022313-2675sjlf	579	33	not	not	RB
cord-022313-2675sjlf	579	34	determined	determine	VBN
cord-022313-2675sjlf	579	35	(	(	-LRB-
cord-022313-2675sjlf	579	36	233	233	CD
cord-022313-2675sjlf	579	37	)	)	-RRB-
cord-022313-2675sjlf	579	38	.	.	.
cord-022313-2675sjlf	580	1	Based	base	VBN
cord-022313-2675sjlf	580	2	on	on	IN
cord-022313-2675sjlf	580	3	the	the	DT
cord-022313-2675sjlf	580	4	above	above	JJ
cord-022313-2675sjlf	580	5	results	result	NNS
cord-022313-2675sjlf	580	6	,	,	,
cord-022313-2675sjlf	580	7	as	as	RB
cord-022313-2675sjlf	580	8	well	well	RB
cord-022313-2675sjlf	580	9	as	as	IN
cord-022313-2675sjlf	580	10	additional	additional	JJ
cord-022313-2675sjlf	580	11	studies	study	NNS
cord-022313-2675sjlf	580	12	on	on	IN
cord-022313-2675sjlf	580	13	the	the	DT
cord-022313-2675sjlf	580	14	levels	level	NNS
cord-022313-2675sjlf	580	15	of	of	IN
cord-022313-2675sjlf	580	16	various	various	JJ
cord-022313-2675sjlf	580	17	intermediates	intermediate	NNS
cord-022313-2675sjlf	580	18	in	in	IN
cord-022313-2675sjlf	580	19	normal	normal	JJ
cord-022313-2675sjlf	580	20	and	and	CC
cord-022313-2675sjlf	580	21	inhibited	inhibited	JJ
cord-022313-2675sjlf	580	22	cells	cell	NNS
cord-022313-2675sjlf	580	23	,	,	,
cord-022313-2675sjlf	580	24	it	-PRON-	PRP
cord-022313-2675sjlf	580	25	was	be	VBD
cord-022313-2675sjlf	580	26	postulated	postulate	VBN
cord-022313-2675sjlf	580	27	that	that	IN
cord-022313-2675sjlf	580	28	the	the	DT
cord-022313-2675sjlf	580	29	mechanism	mechanism	NN
cord-022313-2675sjlf	580	30	of	of	IN
cord-022313-2675sjlf	580	31	inhibition	inhibition	NN
cord-022313-2675sjlf	580	32	involved	involve	VBD
cord-022313-2675sjlf	580	33	a	a	DT
cord-022313-2675sjlf	580	34	feedback	feedback	NN
cord-022313-2675sjlf	580	35	type	type	NN
cord-022313-2675sjlf	580	36	of	of	IN
cord-022313-2675sjlf	580	37	control	control	NN
cord-022313-2675sjlf	580	38	that	that	WDT
cord-022313-2675sjlf	580	39	was	be	VBD
cord-022313-2675sjlf	580	40	caused	cause	VBN
cord-022313-2675sjlf	580	41	by	by	IN
cord-022313-2675sjlf	580	42	ele	ele	NNP
cord-022313-2675sjlf	580	43	vated	vate	VBN
cord-022313-2675sjlf	580	44	levels	level	NNS
cord-022313-2675sjlf	580	45	of	of	IN
cord-022313-2675sjlf	580	46	GTP	GTP	NNP
cord-022313-2675sjlf	580	47	in	in	IN
cord-022313-2675sjlf	580	48	the	the	DT
cord-022313-2675sjlf	580	49	cells	cell	NNS
cord-022313-2675sjlf	580	50	(	(	-LRB-
cord-022313-2675sjlf	580	51	234	234	CD
cord-022313-2675sjlf	580	52	)	)	-RRB-
cord-022313-2675sjlf	580	53	.	.	.
cord-022313-2675sjlf	581	1	In	in	IN
cord-022313-2675sjlf	581	2	N	n	NN
cord-022313-2675sjlf	581	3	-	-	HYPH
cord-022313-2675sjlf	581	4	linked	link	VBN
cord-022313-2675sjlf	581	5	glycosylation	glycosylation	NN
cord-022313-2675sjlf	581	6	,	,	,
cord-022313-2675sjlf	581	7	the	the	DT
cord-022313-2675sjlf	581	8	consensus	consensus	NN
cord-022313-2675sjlf	581	9	sequence	sequence	NN
cord-022313-2675sjlf	581	10	that	that	WDT
cord-022313-2675sjlf	581	11	accepts	accept	VBZ
cord-022313-2675sjlf	581	12	the	the	DT
cord-022313-2675sjlf	581	13	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	581	14	chain	chain	NN
cord-022313-2675sjlf	581	15	is	be	VBZ
cord-022313-2675sjlf	581	16	H	H	NNP
cord-022313-2675sjlf	581	17	3	3	CD
cord-022313-2675sjlf	581	18	N	N	NNP
cord-022313-2675sjlf	581	19	.	.	.
cord-022313-2675sjlf	581	20	.	.	.
cord-022313-2675sjlf	581	21	.	.	.
cord-022313-2675sjlf	582	1	Asn	Asn	NNP
cord-022313-2675sjlf	582	2	-	-	HYPH
cord-022313-2675sjlf	582	3	X	X	NNP
cord-022313-2675sjlf	582	4	-	-	JJ
cord-022313-2675sjlf	582	5	Ser	ser	JJ
cord-022313-2675sjlf	582	6	(	(	-LRB-
cord-022313-2675sjlf	582	7	Thr	Thr	NNP
cord-022313-2675sjlf	582	8	)	)	-RRB-
cord-022313-2675sjlf	582	9	.	.	.
cord-022313-2675sjlf	582	10	.	.	.
cord-022313-2675sjlf	582	11	.	.	.
cord-022313-2675sjlf	582	12	,	,	,
cord-022313-2675sjlf	582	13	where	where	WRB
cord-022313-2675sjlf	582	14	X	x	NN
cord-022313-2675sjlf	582	15	can	can	MD
cord-022313-2675sjlf	582	16	be	be	VB
cord-022313-2675sjlf	582	17	any	any	DT
cord-022313-2675sjlf	582	18	amino	amino	NN
cord-022313-2675sjlf	582	19	acid	acid	NN
cord-022313-2675sjlf	582	20	except	except	IN
cord-022313-2675sjlf	582	21	proline	proline	NN
cord-022313-2675sjlf	582	22	or	or	CC
cord-022313-2675sjlf	582	23	aspartic	aspartic	JJ
cord-022313-2675sjlf	582	24	acid	acid	NN
cord-022313-2675sjlf	582	25	.	.	.
cord-022313-2675sjlf	583	1	This	this	DT
cord-022313-2675sjlf	583	2	sequence	sequence	NN
cord-022313-2675sjlf	583	3	is	be	VBZ
cord-022313-2675sjlf	583	4	,	,	,
cord-022313-2675sjlf	583	5	however	however	RB
cord-022313-2675sjlf	583	6	,	,	,
cord-022313-2675sjlf	583	7	not	not	RB
cord-022313-2675sjlf	583	8	sufficient	sufficient	JJ
cord-022313-2675sjlf	583	9	for	for	IN
cord-022313-2675sjlf	583	10	glycosylation	glycosylation	NN
cord-022313-2675sjlf	583	11	to	to	TO
cord-022313-2675sjlf	583	12	occur	occur	VB
cord-022313-2675sjlf	583	13	,	,	,
cord-022313-2675sjlf	583	14	and	and	CC
cord-022313-2675sjlf	583	15	the	the	DT
cord-022313-2675sjlf	583	16	conforma	conforma	NNP
cord-022313-2675sjlf	583	17	tion	tion	NN
cord-022313-2675sjlf	583	18	of	of	IN
cord-022313-2675sjlf	583	19	the	the	DT
cord-022313-2675sjlf	583	20	protein	protein	NN
cord-022313-2675sjlf	583	21	around	around	IN
cord-022313-2675sjlf	583	22	this	this	DT
cord-022313-2675sjlf	583	23	glycosylation	glycosylation	NN
cord-022313-2675sjlf	583	24	site	site	NN
cord-022313-2675sjlf	583	25	is	be	VBZ
cord-022313-2675sjlf	583	26	apparantly	apparantly	RB
cord-022313-2675sjlf	583	27	also	also	RB
cord-022313-2675sjlf	583	28	critical	critical	JJ
cord-022313-2675sjlf	583	29	.	.	.
cord-022313-2675sjlf	584	1	Statistical	statistical	JJ
cord-022313-2675sjlf	584	2	studies	study	NNS
cord-022313-2675sjlf	584	3	on	on	IN
cord-022313-2675sjlf	584	4	a	a	DT
cord-022313-2675sjlf	584	5	number	number	NN
cord-022313-2675sjlf	584	6	of	of	IN
cord-022313-2675sjlf	584	7	asparagine	asparagine	NN
cord-022313-2675sjlf	584	8	-	-	HYPH
cord-022313-2675sjlf	584	9	linked	link	VBN
cord-022313-2675sjlf	584	10	glycopro	glycopro	NN
cord-022313-2675sjlf	584	11	teins	tein	NNS
cord-022313-2675sjlf	584	12	have	have	VBP
cord-022313-2675sjlf	584	13	indicated	indicate	VBN
cord-022313-2675sjlf	584	14	that	that	IN
cord-022313-2675sjlf	584	15	most	most	JJS
cord-022313-2675sjlf	584	16	of	of	IN
cord-022313-2675sjlf	584	17	the	the	DT
cord-022313-2675sjlf	584	18	asparagine	asparagine	NN
cord-022313-2675sjlf	584	19	residues	residue	NNS
cord-022313-2675sjlf	584	20	that	that	WDT
cord-022313-2675sjlf	584	21	do	do	VBP
cord-022313-2675sjlf	584	22	be	be	VB
cord-022313-2675sjlf	584	23	come	come	VBN
cord-022313-2675sjlf	584	24	glycosylated	glycosylated	JJ
cord-022313-2675sjlf	584	25	are	be	VBP
cord-022313-2675sjlf	584	26	located	locate	VBN
cord-022313-2675sjlf	584	27	in	in	IN
cord-022313-2675sjlf	584	28	regions	region	NNS
cord-022313-2675sjlf	584	29	of	of	IN
cord-022313-2675sjlf	584	30	the	the	DT
cord-022313-2675sjlf	584	31	polypeptide	polypeptide	NN
cord-022313-2675sjlf	584	32	chain	chain	NN
cord-022313-2675sjlf	584	33	that	that	WDT
cord-022313-2675sjlf	584	34	favor	favor	VBP
cord-022313-2675sjlf	584	35	the	the	DT
cord-022313-2675sjlf	584	36	formation	formation	NN
cord-022313-2675sjlf	584	37	of	of	IN
cord-022313-2675sjlf	584	38	/3-turns	/3-turns	.
cord-022313-2675sjlf	584	39	.	.	.
cord-022313-2675sjlf	585	1	The	the	DT
cord-022313-2675sjlf	585	2	importance	importance	NN
cord-022313-2675sjlf	585	3	of	of	IN
cord-022313-2675sjlf	585	4	the	the	DT
cord-022313-2675sjlf	585	5	threonine	threonine	NN
cord-022313-2675sjlf	585	6	residue	residue	NN
cord-022313-2675sjlf	585	7	in	in	IN
cord-022313-2675sjlf	585	8	the	the	DT
cord-022313-2675sjlf	585	9	tripeptide	tripeptide	NN
cord-022313-2675sjlf	585	10	sequence	sequence	NN
cord-022313-2675sjlf	585	11	was	be	VBD
cord-022313-2675sjlf	585	12	examined	examine	VBN
cord-022313-2675sjlf	585	13	by	by	IN
cord-022313-2675sjlf	585	14	using	use	VBG
cord-022313-2675sjlf	585	15	a	a	DT
cord-022313-2675sjlf	585	16	threonine	threonine	NN
cord-022313-2675sjlf	585	17	analog	analog	NN
cord-022313-2675sjlf	585	18	,	,	,
cord-022313-2675sjlf	585	19	β	β	NN
cord-022313-2675sjlf	585	20	-	-	HYPH
cord-022313-2675sjlf	585	21	hydroxynorvaline	hydroxynorvaline	NNP
cord-022313-2675sjlf	585	22	,	,	,
cord-022313-2675sjlf	585	23	and	and	CC
cord-022313-2675sjlf	585	24	determining	determine	VBG
cord-022313-2675sjlf	585	25	its	-PRON-	PRP$
cord-022313-2675sjlf	585	26	effects	effect	NNS
cord-022313-2675sjlf	585	27	on	on	IN
cord-022313-2675sjlf	585	28	cotranslational	cotranslational	JJ
cord-022313-2675sjlf	585	29	glycosylation	glycosylation	NN
cord-022313-2675sjlf	585	30	in	in	IN
cord-022313-2675sjlf	585	31	extracts	extract	NNS
cord-022313-2675sjlf	585	32	of	of	IN
cord-022313-2675sjlf	585	33	ascites	ascites	NN
cord-022313-2675sjlf	585	34	cells	cell	NNS
cord-022313-2675sjlf	585	35	.	.	.
cord-022313-2675sjlf	586	1	This	this	DT
cord-022313-2675sjlf	586	2	analog	analog	NN
cord-022313-2675sjlf	586	3	inhibited	inhibit	VBD
cord-022313-2675sjlf	586	4	the	the	DT
cord-022313-2675sjlf	586	5	glycosylation	glycosylation	NN
cord-022313-2675sjlf	586	6	of	of	IN
cord-022313-2675sjlf	586	7	the	the	DT
cord-022313-2675sjlf	586	8	α	α	NN
cord-022313-2675sjlf	586	9	-	-	HYPH
cord-022313-2675sjlf	586	10	subunit	subunit	NN
cord-022313-2675sjlf	586	11	of	of	IN
cord-022313-2675sjlf	586	12	human	human	JJ
cord-022313-2675sjlf	586	13	chorionic	chorionic	JJ
cord-022313-2675sjlf	586	14	gonadotropin	gonadotropin	NN
cord-022313-2675sjlf	586	15	and	and	CC
cord-022313-2675sjlf	586	16	the	the	DT
cord-022313-2675sjlf	586	17	β	β	XX
cord-022313-2675sjlf	586	18	subunit	subunit	NN
cord-022313-2675sjlf	586	19	of	of	IN
cord-022313-2675sjlf	586	20	bovine	bovine	JJ
cord-022313-2675sjlf	586	21	leutinizing	leutinize	VBG
cord-022313-2675sjlf	586	22	hormone	hormone	NN
cord-022313-2675sjlf	586	23	.	.	.
cord-022313-2675sjlf	587	1	This	this	DT
cord-022313-2675sjlf	587	2	inhibition	inhibition	NN
cord-022313-2675sjlf	587	3	could	could	MD
cord-022313-2675sjlf	587	4	be	be	VB
cord-022313-2675sjlf	587	5	overcome	overcome	VBN
cord-022313-2675sjlf	587	6	by	by	IN
cord-022313-2675sjlf	587	7	adding	add	VBG
cord-022313-2675sjlf	587	8	threonine	threonine	NN
cord-022313-2675sjlf	587	9	,	,	,
cord-022313-2675sjlf	587	10	strongly	strongly	RB
cord-022313-2675sjlf	587	11	suggesting	suggest	VBG
cord-022313-2675sjlf	587	12	that	that	IN
cord-022313-2675sjlf	587	13	the	the	DT
cord-022313-2675sjlf	587	14	analog	analog	NN
cord-022313-2675sjlf	587	15	was	be	VBD
cord-022313-2675sjlf	587	16	inhibiting	inhibit	VBG
cord-022313-2675sjlf	587	17	by	by	IN
cord-022313-2675sjlf	587	18	competing	compete	VBG
cord-022313-2675sjlf	587	19	with	with	IN
cord-022313-2675sjlf	587	20	threonine	threonine	NN
cord-022313-2675sjlf	587	21	for	for	IN
cord-022313-2675sjlf	587	22	incorporation	incorporation	NN
cord-022313-2675sjlf	587	23	into	into	IN
cord-022313-2675sjlf	587	24	protein	protein	NN
cord-022313-2675sjlf	587	25	(	(	-LRB-
cord-022313-2675sjlf	587	26	235	235	CD
cord-022313-2675sjlf	587	27	)	)	-RRB-
cord-022313-2675sjlf	587	28	.	.	.
cord-022313-2675sjlf	588	1	In	in	IN
cord-022313-2675sjlf	588	2	cultured	cultured	JJ
cord-022313-2675sjlf	588	3	fibroblasts	fibroblast	NNS
cord-022313-2675sjlf	588	4	,	,	,
cord-022313-2675sjlf	588	5	β	β	NN
cord-022313-2675sjlf	588	6	-	-	HYPH
cord-022313-2675sjlf	588	7	hydroxynorvaline	hydroxynorvaline	NNP
cord-022313-2675sjlf	588	8	caused	cause	VBD
cord-022313-2675sjlf	588	9	the	the	DT
cord-022313-2675sjlf	588	10	formation	formation	NN
cord-022313-2675sjlf	588	11	of	of	IN
cord-022313-2675sjlf	588	12	a	a	DT
cord-022313-2675sjlf	588	13	variety	variety	NN
cord-022313-2675sjlf	588	14	of	of	IN
cord-022313-2675sjlf	588	15	cathepsin	cathepsin	NN
cord-022313-2675sjlf	588	16	D	d	NN
cord-022313-2675sjlf	588	17	molecules	molecule	NNS
cord-022313-2675sjlf	588	18	that	that	WDT
cord-022313-2675sjlf	588	19	differed	differ	VBD
cord-022313-2675sjlf	588	20	from	from	IN
cord-022313-2675sjlf	588	21	each	each	DT
cord-022313-2675sjlf	588	22	other	other	JJ
cord-022313-2675sjlf	588	23	by	by	IN
cord-022313-2675sjlf	588	24	having	have	VBG
cord-022313-2675sjlf	588	25	one	one	CD
cord-022313-2675sjlf	588	26	,	,	,
cord-022313-2675sjlf	588	27	two	two	CD
cord-022313-2675sjlf	588	28	,	,	,
cord-022313-2675sjlf	588	29	or	or	CC
cord-022313-2675sjlf	588	30	no	no	DT
cord-022313-2675sjlf	588	31	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	588	32	chains	chain	NNS
cord-022313-2675sjlf	588	33	on	on	IN
cord-022313-2675sjlf	588	34	the	the	DT
cord-022313-2675sjlf	588	35	protein	protein	NN
cord-022313-2675sjlf	588	36	.	.	.
cord-022313-2675sjlf	589	1	The	the	DT
cord-022313-2675sjlf	589	2	nonglycosylated	nonglycosylated	JJ
cord-022313-2675sjlf	589	3	form	form	NN
cord-022313-2675sjlf	589	4	of	of	IN
cord-022313-2675sjlf	589	5	cathepsin	cathepsin	NN
cord-022313-2675sjlf	589	6	was	be	VBD
cord-022313-2675sjlf	589	7	a	a	DT
cord-022313-2675sjlf	589	8	minor	minor	JJ
cord-022313-2675sjlf	589	9	component	component	NN
cord-022313-2675sjlf	589	10	and	and	CC
cord-022313-2675sjlf	589	11	it	-PRON-	PRP
cord-022313-2675sjlf	589	12	was	be	VBD
cord-022313-2675sjlf	589	13	rapidly	rapidly	RB
cord-022313-2675sjlf	589	14	degraded	degrade	VBN
cord-022313-2675sjlf	589	15	within	within	IN
cord-022313-2675sjlf	589	16	45	45	CD
cord-022313-2675sjlf	589	17	min	min	NN
cord-022313-2675sjlf	589	18	of	of	IN
cord-022313-2675sjlf	589	19	its	-PRON-	PRP$
cord-022313-2675sjlf	589	20	synthesis	synthesis	NN
cord-022313-2675sjlf	589	21	.	.	.
cord-022313-2675sjlf	590	1	However	however	RB
cord-022313-2675sjlf	590	2	,	,	,
cord-022313-2675sjlf	590	3	those	those	DT
cord-022313-2675sjlf	590	4	forms	form	NNS
cord-022313-2675sjlf	590	5	having	have	VBG
cord-022313-2675sjlf	590	6	one	one	CD
cord-022313-2675sjlf	590	7	or	or	CC
cord-022313-2675sjlf	590	8	two	two	CD
cord-022313-2675sjlf	590	9	oligo	oligo	NN
cord-022313-2675sjlf	590	10	-	-	HYPH
cord-022313-2675sjlf	590	11	saccharide	saccharide	JJ
cord-022313-2675sjlf	590	12	chains	chain	NNS
cord-022313-2675sjlf	590	13	behaved	behave	VBD
cord-022313-2675sjlf	590	14	normally	normally	RB
cord-022313-2675sjlf	590	15	,	,	,
cord-022313-2675sjlf	590	16	were	be	VBD
cord-022313-2675sjlf	590	17	segregated	segregate	VBN
cord-022313-2675sjlf	590	18	to	to	IN
cord-022313-2675sjlf	590	19	the	the	DT
cord-022313-2675sjlf	590	20	lysosomes	lysosome	NNS
cord-022313-2675sjlf	590	21	,	,	,
cord-022313-2675sjlf	590	22	and	and	CC
cord-022313-2675sjlf	590	23	underwent	undergo	VBD
cord-022313-2675sjlf	590	24	proteolytic	proteolytic	JJ
cord-022313-2675sjlf	590	25	maturation	maturation	NN
cord-022313-2675sjlf	590	26	in	in	IN
cord-022313-2675sjlf	590	27	the	the	DT
cord-022313-2675sjlf	590	28	usual	usual	JJ
cord-022313-2675sjlf	590	29	fashion	fashion	NN
cord-022313-2675sjlf	590	30	(	(	-LRB-
cord-022313-2675sjlf	590	31	236	236	CD
cord-022313-2675sjlf	590	32	)	)	-RRB-
cord-022313-2675sjlf	590	33	.	.	.
cord-022313-2675sjlf	591	1	Simi	Simi	NNP
cord-022313-2675sjlf	591	2	lar	lar	NNP
cord-022313-2675sjlf	591	3	types	type	NNS
cord-022313-2675sjlf	591	4	of	of	IN
cord-022313-2675sjlf	591	5	results	result	NNS
cord-022313-2675sjlf	591	6	were	be	VBD
cord-022313-2675sjlf	591	7	observed	observe	VBN
cord-022313-2675sjlf	591	8	with	with	IN
cord-022313-2675sjlf	591	9	respect	respect	NN
cord-022313-2675sjlf	591	10	to	to	IN
cord-022313-2675sjlf	591	11	the	the	DT
cord-022313-2675sjlf	591	12	effects	effect	NNS
cord-022313-2675sjlf	591	13	of	of	IN
cord-022313-2675sjlf	591	14	this	this	DT
cord-022313-2675sjlf	591	15	analog	analog	NN
cord-022313-2675sjlf	591	16	on	on	IN
cord-022313-2675sjlf	591	17	the	the	DT
cord-022313-2675sjlf	591	18	formation	formation	NN
cord-022313-2675sjlf	591	19	of	of	IN
cord-022313-2675sjlf	591	20	a	a	DT
cord-022313-2675sjlf	591	21	r	r	NN
cord-022313-2675sjlf	591	22	acid	acid	NN
cord-022313-2675sjlf	591	23	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	591	24	(	(	-LRB-
cord-022313-2675sjlf	591	25	237	237	CD
cord-022313-2675sjlf	591	26	)	)	-RRB-
cord-022313-2675sjlf	591	27	.	.	.
cord-022313-2675sjlf	592	1	Another	another	DT
cord-022313-2675sjlf	592	2	amino	amino	NN
cord-022313-2675sjlf	592	3	acid	acid	NN
cord-022313-2675sjlf	592	4	analog	analog	NN
cord-022313-2675sjlf	592	5	that	that	WDT
cord-022313-2675sjlf	592	6	has	have	VBZ
cord-022313-2675sjlf	592	7	interesting	interesting	JJ
cord-022313-2675sjlf	592	8	effects	effect	NNS
cord-022313-2675sjlf	592	9	on	on	IN
cord-022313-2675sjlf	592	10	glycosyla	glycosyla	NNP
cord-022313-2675sjlf	592	11	tion	tion	NN
cord-022313-2675sjlf	592	12	is	be	VBZ
cord-022313-2675sjlf	592	13	threo-/3-fluoroasparagine	threo-/3-fluoroasparagine	NNP
cord-022313-2675sjlf	592	14	.	.	.
cord-022313-2675sjlf	593	1	This	this	DT
cord-022313-2675sjlf	593	2	analog	analog	NN
cord-022313-2675sjlf	593	3	is	be	VBZ
cord-022313-2675sjlf	593	4	toxic	toxic	JJ
cord-022313-2675sjlf	593	5	to	to	IN
cord-022313-2675sjlf	593	6	asparaginedependent	asparaginedependent	NN
cord-022313-2675sjlf	593	7	cells	cell	NNS
cord-022313-2675sjlf	593	8	when	when	WRB
cord-022313-2675sjlf	593	9	aspartic	aspartic	JJ
cord-022313-2675sjlf	593	10	acid	acid	NN
cord-022313-2675sjlf	593	11	is	be	VBZ
cord-022313-2675sjlf	593	12	included	include	VBN
cord-022313-2675sjlf	593	13	in	in	IN
cord-022313-2675sjlf	593	14	the	the	DT
cord-022313-2675sjlf	593	15	culture	culture	NN
cord-022313-2675sjlf	593	16	medium	medium	NN
cord-022313-2675sjlf	593	17	.	.	.
cord-022313-2675sjlf	594	1	The	the	DT
cord-022313-2675sjlf	594	2	actual	actual	JJ
cord-022313-2675sjlf	594	3	mechanism	mechanism	NN
cord-022313-2675sjlf	594	4	of	of	IN
cord-022313-2675sjlf	594	5	toxicity	toxicity	NN
cord-022313-2675sjlf	594	6	has	have	VBZ
cord-022313-2675sjlf	594	7	not	not	RB
cord-022313-2675sjlf	594	8	been	be	VBN
cord-022313-2675sjlf	594	9	determined	determine	VBN
cord-022313-2675sjlf	594	10	but	but	CC
cord-022313-2675sjlf	594	11	it	-PRON-	PRP
cord-022313-2675sjlf	594	12	is	be	VBZ
cord-022313-2675sjlf	594	13	believed	believe	VBN
cord-022313-2675sjlf	594	14	to	to	TO
cord-022313-2675sjlf	594	15	be	be	VB
cord-022313-2675sjlf	594	16	due	due	JJ
cord-022313-2675sjlf	594	17	to	to	IN
cord-022313-2675sjlf	594	18	the	the	DT
cord-022313-2675sjlf	594	19	incorporation	incorporation	NN
cord-022313-2675sjlf	594	20	of	of	IN
cord-022313-2675sjlf	594	21	the	the	DT
cord-022313-2675sjlf	594	22	analog	analog	NN
cord-022313-2675sjlf	594	23	into	into	IN
cord-022313-2675sjlf	594	24	protein	protein	NN
cord-022313-2675sjlf	594	25	.	.	.
cord-022313-2675sjlf	595	1	At	at	IN
cord-022313-2675sjlf	595	2	1	1	CD
cord-022313-2675sjlf	595	3	mM	mm	CD
cord-022313-2675sjlf	595	4	concentrations	concentration	NNS
cord-022313-2675sjlf	595	5	,	,	,
cord-022313-2675sjlf	595	6	this	this	DT
cord-022313-2675sjlf	595	7	analog	analog	NN
cord-022313-2675sjlf	595	8	strongly	strongly	RB
cord-022313-2675sjlf	595	9	inhibits	inhibit	VBZ
cord-022313-2675sjlf	595	10	glycosylation	glycosylation	NN
cord-022313-2675sjlf	595	11	but	but	CC
cord-022313-2675sjlf	595	12	this	this	DT
cord-022313-2675sjlf	595	13	inhibition	inhibition	NN
cord-022313-2675sjlf	595	14	is	be	VBZ
cord-022313-2675sjlf	595	15	blocked	block	VBN
cord-022313-2675sjlf	595	16	by	by	IN
cord-022313-2675sjlf	595	17	adding	add	VBG
cord-022313-2675sjlf	595	18	asparagine	asparagine	NN
cord-022313-2675sjlf	595	19	,	,	,
cord-022313-2675sjlf	595	20	further	further	RB
cord-022313-2675sjlf	595	21	strengthening	strengthen	VBG
cord-022313-2675sjlf	595	22	the	the	DT
cord-022313-2675sjlf	595	23	idea	idea	NN
cord-022313-2675sjlf	595	24	that	that	IN
cord-022313-2675sjlf	595	25	the	the	DT
cord-022313-2675sjlf	595	26	analog	analog	NN
cord-022313-2675sjlf	595	27	is	be	VBZ
cord-022313-2675sjlf	595	28	incorporated	incorporate	VBN
cord-022313-2675sjlf	595	29	.	.	.
cord-022313-2675sjlf	596	1	However	however	RB
cord-022313-2675sjlf	596	2	,	,	,
cord-022313-2675sjlf	596	3	the	the	DT
cord-022313-2675sjlf	596	4	erythro	erythro	NN
cord-022313-2675sjlf	596	5	-	-	HYPH
cord-022313-2675sjlf	596	6	analog	analog	NN
cord-022313-2675sjlf	596	7	was	be	VBD
cord-022313-2675sjlf	596	8	not	not	RB
cord-022313-2675sjlf	596	9	an	an	DT
cord-022313-2675sjlf	596	10	inhibitor	inhibitor	NN
cord-022313-2675sjlf	596	11	of	of	IN
cord-022313-2675sjlf	596	12	glycosylation	glycosylation	NN
cord-022313-2675sjlf	596	13	(	(	-LRB-
cord-022313-2675sjlf	596	14	238	238	CD
cord-022313-2675sjlf	596	15	)	)	-RRB-
cord-022313-2675sjlf	596	16	.	.	.
cord-022313-2675sjlf	597	1	Interestingly	interestingly	RB
cord-022313-2675sjlf	597	2	enough	enough	RB
cord-022313-2675sjlf	597	3	,	,	,
cord-022313-2675sjlf	597	4	when	when	WRB
cord-022313-2675sjlf	597	5	the	the	DT
cord-022313-2675sjlf	597	6	above	above	JJ
cord-022313-2675sjlf	597	7	two	two	CD
cord-022313-2675sjlf	597	8	amino	amino	NN
cord-022313-2675sjlf	597	9	acid	acid	NN
cord-022313-2675sjlf	597	10	analogs	analog	NNS
cord-022313-2675sjlf	597	11	(	(	-LRB-
cord-022313-2675sjlf	597	12	i.e.	i.e.	FW
cord-022313-2675sjlf	597	13	,	,	,
cord-022313-2675sjlf	597	14	β	β	NN
cord-022313-2675sjlf	597	15	-	-	HYPH
cord-022313-2675sjlf	597	16	hydroxynorvaline	hydroxynorvaline	NNP
cord-022313-2675sjlf	597	17	and	and	CC
cord-022313-2675sjlf	597	18	threoβ	threoβ	NNP
cord-022313-2675sjlf	597	19	-	-	HYPH
cord-022313-2675sjlf	597	20	fluoroasparagine	fluoroasparagine	NNP
cord-022313-2675sjlf	597	21	)	)	-RRB-
cord-022313-2675sjlf	597	22	were	be	VBD
cord-022313-2675sjlf	597	23	used	use	VBN
cord-022313-2675sjlf	597	24	to	to	TO
cord-022313-2675sjlf	597	25	inhibit	inhibit	VB
cord-022313-2675sjlf	597	26	protein	protein	NN
cord-022313-2675sjlf	597	27	synthesis	synthesis	NN
cord-022313-2675sjlf	597	28	,	,	,
cord-022313-2675sjlf	597	29	they	-PRON-	PRP
cord-022313-2675sjlf	597	30	also	also	RB
cord-022313-2675sjlf	597	31	inhibited	inhibit	VBD
cord-022313-2675sjlf	597	32	the	the	DT
cord-022313-2675sjlf	597	33	incorporation	incorporation	NN
cord-022313-2675sjlf	597	34	of	of	IN
cord-022313-2675sjlf	597	35	radioactive	radioactive	JJ
cord-022313-2675sjlf	597	36	mannose	mannose	NN
cord-022313-2675sjlf	597	37	into	into	IN
cord-022313-2675sjlf	597	38	lipid	lipid	NN
cord-022313-2675sjlf	597	39	-	-	HYPH
cord-022313-2675sjlf	597	40	linked	link	VBN
cord-022313-2675sjlf	597	41	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	597	42	as	as	IN
cord-022313-2675sjlf	597	43	demonstrated	demonstrate	VBN
cord-022313-2675sjlf	597	44	with	with	IN
cord-022313-2675sjlf	597	45	cycloheximide	cycloheximide	NN
cord-022313-2675sjlf	597	46	and	and	CC
cord-022313-2675sjlf	597	47	puromycin	puromycin	NNS
cord-022313-2675sjlf	597	48	(	(	-LRB-
cord-022313-2675sjlf	597	49	232	232	CD
cord-022313-2675sjlf	597	50	)	)	-RRB-
cord-022313-2675sjlf	597	51	.	.	.
cord-022313-2675sjlf	598	1	It	-PRON-	PRP
cord-022313-2675sjlf	598	2	seems	seem	VBZ
cord-022313-2675sjlf	598	3	likely	likely	JJ
cord-022313-2675sjlf	598	4	that	that	IN
cord-022313-2675sjlf	598	5	the	the	DT
cord-022313-2675sjlf	598	6	toxicity	toxicity	NN
cord-022313-2675sjlf	598	7	of	of	IN
cord-022313-2675sjlf	598	8	fluoroasparagine	fluoroasparagine	NN
cord-022313-2675sjlf	598	9	is	be	VBZ
cord-022313-2675sjlf	598	10	due	due	JJ
cord-022313-2675sjlf	598	11	to	to	IN
cord-022313-2675sjlf	598	12	its	-PRON-	PRP$
cord-022313-2675sjlf	598	13	preventing	prevent	VBG
cord-022313-2675sjlf	598	14	the	the	DT
cord-022313-2675sjlf	598	15	cells	cell	NNS
cord-022313-2675sjlf	598	16	from	from	IN
cord-022313-2675sjlf	598	17	glycosylating	glycosylate	VBG
cord-022313-2675sjlf	598	18	their	-PRON-	PRP$
cord-022313-2675sjlf	598	19	N	n	CD
cord-022313-2675sjlf	598	20	-	-	HYPH
cord-022313-2675sjlf	598	21	linked	link	VBN
cord-022313-2675sjlf	598	22	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	598	23	in	in	IN
cord-022313-2675sjlf	598	24	much	much	RB
cord-022313-2675sjlf	598	25	the	the	DT
cord-022313-2675sjlf	598	26	same	same	JJ
cord-022313-2675sjlf	598	27	manner	manner	NN
cord-022313-2675sjlf	598	28	as	as	IN
cord-022313-2675sjlf	598	29	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	598	30	.	.	.
cord-022313-2675sjlf	599	1	VII	VII	NNP
cord-022313-2675sjlf	599	2	.	.	.
cord-022313-2675sjlf	600	1	As	as	IN
cord-022313-2675sjlf	600	2	indicated	indicate	VBN
cord-022313-2675sjlf	600	3	earlier	early	RBR
cord-022313-2675sjlf	600	4	,	,	,
cord-022313-2675sjlf	600	5	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	600	6	-	-	HYPH
cord-022313-2675sjlf	600	7	P	P	NNP
cord-022313-2675sjlf	600	8	serves	serve	VBZ
cord-022313-2675sjlf	600	9	as	as	IN
cord-022313-2675sjlf	600	10	an	an	DT
cord-022313-2675sjlf	600	11	obligatory	obligatory	JJ
cord-022313-2675sjlf	600	12	carrier	carrier	NN
cord-022313-2675sjlf	600	13	in	in	IN
cord-022313-2675sjlf	600	14	the	the	DT
cord-022313-2675sjlf	600	15	glycosylation	glycosylation	NN
cord-022313-2675sjlf	600	16	of	of	IN
cord-022313-2675sjlf	600	17	N	n	NN
cord-022313-2675sjlf	600	18	-	-	HYPH
cord-022313-2675sjlf	600	19	linked	link	VBN
cord-022313-2675sjlf	600	20	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	600	21	.	.	.
cord-022313-2675sjlf	601	1	Dolichyl	Dolichyl	NNP
cord-022313-2675sjlf	601	2	-	-	HYPH
cord-022313-2675sjlf	601	3	P	P	NNP
cord-022313-2675sjlf	601	4	is	be	VBZ
cord-022313-2675sjlf	601	5	produced	produce	VBN
cord-022313-2675sjlf	601	6	by	by	IN
cord-022313-2675sjlf	601	7	the	the	DT
cord-022313-2675sjlf	601	8	same	same	JJ
cord-022313-2675sjlf	601	9	initial	initial	JJ
cord-022313-2675sjlf	601	10	pathway	pathway	NN
cord-022313-2675sjlf	601	11	as	as	IN
cord-022313-2675sjlf	601	12	that	that	DT
cord-022313-2675sjlf	601	13	responsible	responsible	JJ
cord-022313-2675sjlf	601	14	for	for	IN
cord-022313-2675sjlf	601	15	the	the	DT
cord-022313-2675sjlf	601	16	synthesis	synthesis	NN
cord-022313-2675sjlf	601	17	of	of	IN
cord-022313-2675sjlf	601	18	polyprenol	polyprenol	JJ
cord-022313-2675sjlf	601	19	units	unit	NNS
cord-022313-2675sjlf	601	20	and	and	CC
cord-022313-2675sjlf	601	21	,	,	,
cord-022313-2675sjlf	601	22	therefore	therefore	RB
cord-022313-2675sjlf	601	23	,	,	,
cord-022313-2675sjlf	601	24	one	one	PRP
cord-022313-2675sjlf	601	25	would	would	MD
cord-022313-2675sjlf	601	26	anticipate	anticipate	VB
cord-022313-2675sjlf	601	27	that	that	IN
cord-022313-2675sjlf	601	28	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	601	29	of	of	IN
cord-022313-2675sjlf	601	30	polyprenol	polyprenol	JJ
cord-022313-2675sjlf	601	31	formation	formation	NN
cord-022313-2675sjlf	601	32	should	should	MD
cord-022313-2675sjlf	601	33	also	also	RB
cord-022313-2675sjlf	601	34	inhibit	inhibit	VB
cord-022313-2675sjlf	601	35	dolichyl	dolichyl	NN
cord-022313-2675sjlf	601	36	-	-	HYPH
cord-022313-2675sjlf	601	37	P	p	NN
cord-022313-2675sjlf	601	38	formation	formation	NN
cord-022313-2675sjlf	601	39	.	.	.
cord-022313-2675sjlf	602	1	Fur	fur	NN
cord-022313-2675sjlf	602	2	thermore	thermore	NN
cord-022313-2675sjlf	602	3	,	,	,
cord-022313-2675sjlf	602	4	such	such	JJ
cord-022313-2675sjlf	602	5	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	602	6	should	should	MD
cord-022313-2675sjlf	602	7	also	also	RB
cord-022313-2675sjlf	602	8	have	have	VB
cord-022313-2675sjlf	602	9	a	a	DT
cord-022313-2675sjlf	602	10	potent	potent	JJ
cord-022313-2675sjlf	602	11	effect	effect	NN
cord-022313-2675sjlf	602	12	on	on	IN
cord-022313-2675sjlf	602	13	the	the	DT
cord-022313-2675sjlf	602	14	gly	gly	NNP
cord-022313-2675sjlf	602	15	cosylation	cosylation	NN
cord-022313-2675sjlf	602	16	of	of	IN
cord-022313-2675sjlf	602	17	asparagine	asparagine	NN
cord-022313-2675sjlf	602	18	-	-	HYPH
cord-022313-2675sjlf	602	19	linked	link	VBN
cord-022313-2675sjlf	602	20	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	602	21	.	.	.
cord-022313-2675sjlf	603	1	Since	since	IN
cord-022313-2675sjlf	603	2	the	the	DT
cord-022313-2675sjlf	603	3	formation	formation	NN
cord-022313-2675sjlf	603	4	of	of	IN
cord-022313-2675sjlf	603	5	polyphenols	polyphenol	NNS
cord-022313-2675sjlf	603	6	utilizes	utilize	VBZ
cord-022313-2675sjlf	603	7	the	the	DT
cord-022313-2675sjlf	603	8	rate	rate	NN
cord-022313-2675sjlf	603	9	-	-	HYPH
cord-022313-2675sjlf	603	10	limiting	limit	VBG
cord-022313-2675sjlf	603	11	step	step	NN
cord-022313-2675sjlf	603	12	catalyzed	catalyze	VBN
cord-022313-2675sjlf	603	13	by	by	IN
cord-022313-2675sjlf	603	14	the	the	DT
cord-022313-2675sjlf	603	15	enzyme	enzyme	NN
cord-022313-2675sjlf	603	16	hydroxymethylglutaryl	hydroxymethylglutaryl	NNP
cord-022313-2675sjlf	603	17	-	-	:
cord-022313-2675sjlf	603	18	Co	Co	NNP
cord-022313-2675sjlf	603	19	A	a	DT
cord-022313-2675sjlf	603	20	reductase	reductase	NN
cord-022313-2675sjlf	603	21	(	(	-LRB-
cord-022313-2675sjlf	603	22	HMG	HMG	NNP
cord-022313-2675sjlf	603	23	CoA	coa	NN
cord-022313-2675sjlf	603	24	reductase	reductase	NN
cord-022313-2675sjlf	603	25	)	)	-RRB-
cord-022313-2675sjlf	603	26	,	,	,
cord-022313-2675sjlf	603	27	inhibi	inhibi	NNP
cord-022313-2675sjlf	603	28	tors	tor	NNS
cord-022313-2675sjlf	603	29	of	of	IN
cord-022313-2675sjlf	603	30	this	this	DT
cord-022313-2675sjlf	603	31	enzyme	enzyme	NN
cord-022313-2675sjlf	603	32	such	such	JJ
cord-022313-2675sjlf	603	33	as	as	IN
cord-022313-2675sjlf	603	34	25-hydroxycholesterol	25-hydroxycholesterol	CD
cord-022313-2675sjlf	603	35	and	and	CC
cord-022313-2675sjlf	603	36	compactin	compactin	NNP
cord-022313-2675sjlf	603	37	(	(	-LRB-
cord-022313-2675sjlf	603	38	or	or	CC
cord-022313-2675sjlf	603	39	mevanolin	mevanolin	NNP
cord-022313-2675sjlf	603	40	)	)	-RRB-
cord-022313-2675sjlf	603	41	should	should	MD
cord-022313-2675sjlf	603	42	also	also	RB
cord-022313-2675sjlf	603	43	inhibit	inhibit	VB
cord-022313-2675sjlf	603	44	glycosylation	glycosylation	NN
cord-022313-2675sjlf	603	45	.	.	.
cord-022313-2675sjlf	604	1	When	when	WRB
cord-022313-2675sjlf	604	2	smooth	smooth	JJ
cord-022313-2675sjlf	604	3	muscle	muscle	NN
cord-022313-2675sjlf	604	4	cells	cell	NNS
cord-022313-2675sjlf	604	5	,	,	,
cord-022313-2675sjlf	604	6	derived	derive	VBN
cord-022313-2675sjlf	604	7	from	from	IN
cord-022313-2675sjlf	604	8	aorta	aorta	NN
cord-022313-2675sjlf	604	9	,	,	,
cord-022313-2675sjlf	604	10	are	be	VBP
cord-022313-2675sjlf	604	11	grown	grow	VBN
cord-022313-2675sjlf	604	12	in	in	IN
cord-022313-2675sjlf	604	13	the	the	DT
cord-022313-2675sjlf	604	14	presence	presence	NN
cord-022313-2675sjlf	604	15	of	of	IN
cord-022313-2675sjlf	604	16	25-hydroxycholesterol	25-hydroxycholesterol	CD
cord-022313-2675sjlf	604	17	,	,	,
cord-022313-2675sjlf	604	18	the	the	DT
cord-022313-2675sjlf	604	19	incorporation	incorporation	NN
cord-022313-2675sjlf	604	20	of	of	IN
cord-022313-2675sjlf	604	21	[	[	-LRB-
cord-022313-2675sjlf	604	22	14	14	CD
cord-022313-2675sjlf	604	23	C]acetate	C]acetate	NNP
cord-022313-2675sjlf	604	24	into	into	IN
cord-022313-2675sjlf	604	25	cholesterol	cholesterol	NN
cord-022313-2675sjlf	604	26	and	and	CC
cord-022313-2675sjlf	604	27	into	into	IN
cord-022313-2675sjlf	604	28	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	604	29	-	-	HYPH
cord-022313-2675sjlf	604	30	P	p	NN
cord-022313-2675sjlf	604	31	is	be	VBZ
cord-022313-2675sjlf	604	32	inhibited	inhibit	VBN
cord-022313-2675sjlf	604	33	by	by	IN
cord-022313-2675sjlf	604	34	up	up	IN
cord-022313-2675sjlf	604	35	to	to	TO
cord-022313-2675sjlf	604	36	90	90	CD
cord-022313-2675sjlf	604	37	%	%	NN
cord-022313-2675sjlf	604	38	,	,	,
cord-022313-2675sjlf	604	39	as	as	IN
cord-022313-2675sjlf	604	40	is	be	VBZ
cord-022313-2675sjlf	604	41	N	n	CD
cord-022313-2675sjlf	604	42	-	-	HYPH
cord-022313-2675sjlf	604	43	linked	link	VBN
cord-022313-2675sjlf	604	44	glycosylation	glycosylation	NN
cord-022313-2675sjlf	604	45	.	.	.
cord-022313-2675sjlf	605	1	However	however	RB
cord-022313-2675sjlf	605	2	,	,	,
cord-022313-2675sjlf	605	3	mevalonate	mevalonate	NN
cord-022313-2675sjlf	605	4	incorporation	incorporation	NN
cord-022313-2675sjlf	605	5	into	into	IN
cord-022313-2675sjlf	605	6	these	these	DT
cord-022313-2675sjlf	605	7	lipids	lipid	NNS
cord-022313-2675sjlf	605	8	is	be	VBZ
cord-022313-2675sjlf	605	9	unaffected	unaffected	JJ
cord-022313-2675sjlf	605	10	,	,	,
cord-022313-2675sjlf	605	11	as	as	IN
cord-022313-2675sjlf	605	12	expected	expect	VBN
cord-022313-2675sjlf	605	13	.	.	.
cord-022313-2675sjlf	606	1	Mevalonate	Mevalonate	NNP
cord-022313-2675sjlf	606	2	,	,	,
cord-022313-2675sjlf	606	3	in	in	IN
cord-022313-2675sjlf	606	4	fact	fact	NN
cord-022313-2675sjlf	606	5	,	,	,
cord-022313-2675sjlf	606	6	when	when	WRB
cord-022313-2675sjlf	606	7	added	add	VBN
cord-022313-2675sjlf	606	8	to	to	IN
cord-022313-2675sjlf	606	9	inhibited	inhibited	JJ
cord-022313-2675sjlf	606	10	cells	cell	NNS
cord-022313-2675sjlf	606	11	,	,	,
cord-022313-2675sjlf	606	12	can	can	MD
cord-022313-2675sjlf	606	13	overcome	overcome	VB
cord-022313-2675sjlf	606	14	the	the	DT
cord-022313-2675sjlf	606	15	inhibition	inhibition	NN
cord-022313-2675sjlf	606	16	with	with	IN
cord-022313-2675sjlf	606	17	respect	respect	NN
cord-022313-2675sjlf	606	18	to	to	IN
cord-022313-2675sjlf	606	19	N	n	NN
cord-022313-2675sjlf	606	20	-	-	HYPH
cord-022313-2675sjlf	606	21	linked	link	VBN
cord-022313-2675sjlf	606	22	glycosylation	glycosylation	NN
cord-022313-2675sjlf	606	23	,	,	,
cord-022313-2675sjlf	606	24	presumably	presumably	RB
cord-022313-2675sjlf	606	25	because	because	IN
cord-022313-2675sjlf	606	26	it	-PRON-	PRP
cord-022313-2675sjlf	606	27	allows	allow	VBZ
cord-022313-2675sjlf	606	28	dolichyl	dolichyl	NN
cord-022313-2675sjlf	606	29	-	-	HYPH
cord-022313-2675sjlf	606	30	P	p	NN
cord-022313-2675sjlf	606	31	to	to	TO
cord-022313-2675sjlf	606	32	be	be	VB
cord-022313-2675sjlf	606	33	formed	form	VBN
cord-022313-2675sjlf	606	34	(	(	-LRB-
cord-022313-2675sjlf	606	35	239	239	CD
cord-022313-2675sjlf	606	36	)	)	-RRB-
cord-022313-2675sjlf	606	37	.	.	.
cord-022313-2675sjlf	607	1	On	on	IN
cord-022313-2675sjlf	607	2	the	the	DT
cord-022313-2675sjlf	607	3	other	other	JJ
cord-022313-2675sjlf	607	4	hand	hand	NN
cord-022313-2675sjlf	607	5	,	,	,
cord-022313-2675sjlf	607	6	in	in	IN
cord-022313-2675sjlf	607	7	mouse	mouse	NN
cord-022313-2675sjlf	607	8	L	L	NNP
cord-022313-2675sjlf	607	9	cells	cell	NNS
cord-022313-2675sjlf	607	10	,	,	,
cord-022313-2675sjlf	607	11	hydroxycholesterol	hydroxycholesterol	NNP
cord-022313-2675sjlf	607	12	also	also	RB
cord-022313-2675sjlf	607	13	affected	affect	VBD
cord-022313-2675sjlf	607	14	the	the	DT
cord-022313-2675sjlf	607	15	synthesis	synthesis	NN
cord-022313-2675sjlf	607	16	of	of	IN
cord-022313-2675sjlf	607	17	dolichol	dolichol	NNP
cord-022313-2675sjlf	607	18	and	and	CC
cord-022313-2675sjlf	607	19	cholesterol	cholesterol	NN
cord-022313-2675sjlf	607	20	,	,	,
cord-022313-2675sjlf	607	21	but	but	CC
cord-022313-2675sjlf	607	22	in	in	IN
cord-022313-2675sjlf	607	23	this	this	DT
cord-022313-2675sjlf	607	24	system	system	NN
cord-022313-2675sjlf	607	25	,	,	,
cord-022313-2675sjlf	607	26	there	there	EX
cord-022313-2675sjlf	607	27	were	be	VBD
cord-022313-2675sjlf	607	28	conditions	condition	NNS
cord-022313-2675sjlf	607	29	that	that	WDT
cord-022313-2675sjlf	607	30	gave	give	VBD
cord-022313-2675sjlf	607	31	great	great	JJ
cord-022313-2675sjlf	607	32	fluctuations	fluctuation	NNS
cord-022313-2675sjlf	607	33	in	in	IN
cord-022313-2675sjlf	607	34	cholesterol	cholesterol	NN
cord-022313-2675sjlf	607	35	synthesis	synthesis	NN
cord-022313-2675sjlf	607	36	but	but	CC
cord-022313-2675sjlf	607	37	only	only	JJ
cord-022313-2675sjlf	607	38	slight	slight	JJ
cord-022313-2675sjlf	607	39	effects	effect	NNS
cord-022313-2675sjlf	607	40	on	on	IN
cord-022313-2675sjlf	607	41	dolichyl	dolichyl	NN
cord-022313-2675sjlf	607	42	-	-	HYPH
cord-022313-2675sjlf	607	43	P	p	NN
cord-022313-2675sjlf	607	44	formation	formation	NN
cord-022313-2675sjlf	607	45	.	.	.
cord-022313-2675sjlf	608	1	The	the	DT
cord-022313-2675sjlf	608	2	authors	author	NNS
cord-022313-2675sjlf	608	3	postulated	postulate	VBD
cord-022313-2675sjlf	608	4	that	that	IN
cord-022313-2675sjlf	608	5	there	there	EX
cord-022313-2675sjlf	608	6	were	be	VBD
cord-022313-2675sjlf	608	7	other	other	JJ
cord-022313-2675sjlf	608	8	points	point	NNS
cord-022313-2675sjlf	608	9	in	in	IN
cord-022313-2675sjlf	608	10	the	the	DT
cord-022313-2675sjlf	608	11	pathway	pathway	NN
cord-022313-2675sjlf	608	12	that	that	WDT
cord-022313-2675sjlf	608	13	must	must	MD
cord-022313-2675sjlf	608	14	control	control	VB
cord-022313-2675sjlf	608	15	the	the	DT
cord-022313-2675sjlf	608	16	levels	level	NNS
cord-022313-2675sjlf	608	17	of	of	IN
cord-022313-2675sjlf	608	18	these	these	DT
cord-022313-2675sjlf	608	19	two	two	CD
cord-022313-2675sjlf	608	20	lipids	lipid	NNS
cord-022313-2675sjlf	608	21	(	(	-LRB-
cord-022313-2675sjlf	608	22	i.e.	i.e.	FW
cord-022313-2675sjlf	608	23	,	,	,
cord-022313-2675sjlf	608	24	cholesterol	cholesterol	NN
cord-022313-2675sjlf	608	25	and	and	CC
cord-022313-2675sjlf	608	26	dolichol	dolichol	NN
cord-022313-2675sjlf	608	27	)	)	-RRB-
cord-022313-2675sjlf	608	28	(	(	-LRB-
cord-022313-2675sjlf	608	29	240	240	CD
cord-022313-2675sjlf	608	30	)	)	-RRB-
cord-022313-2675sjlf	608	31	.	.	.
cord-022313-2675sjlf	609	1	Cholestyramineis	Cholestyramineis	NNP
cord-022313-2675sjlf	609	2	a	a	DT
cord-022313-2675sjlf	609	3	compound	compound	NN
cord-022313-2675sjlf	609	4	that	that	IN
cord-022313-2675sjlf	609	5	when	when	WRB
cord-022313-2675sjlf	609	6	fed	feed	VBN
cord-022313-2675sjlf	609	7	to	to	IN
cord-022313-2675sjlf	609	8	animals	animal	NNS
cord-022313-2675sjlf	609	9	causes	cause	VBZ
cord-022313-2675sjlf	609	10	an	an	DT
cord-022313-2675sjlf	609	11	increase	increase	NN
cord-022313-2675sjlf	609	12	in	in	IN
cord-022313-2675sjlf	609	13	the	the	DT
cord-022313-2675sjlf	609	14	activity	activity	NN
cord-022313-2675sjlf	609	15	of	of	IN
cord-022313-2675sjlf	609	16	HMG	HMG	NNP
cord-022313-2675sjlf	609	17	CoA	coa	NN
cord-022313-2675sjlf	609	18	reductase	reductase	NN
cord-022313-2675sjlf	609	19	and	and	CC
cord-022313-2675sjlf	609	20	a	a	DT
cord-022313-2675sjlf	609	21	great	great	JJ
cord-022313-2675sjlf	609	22	stimulation	stimulation	NN
cord-022313-2675sjlf	609	23	in	in	IN
cord-022313-2675sjlf	609	24	the	the	DT
cord-022313-2675sjlf	609	25	incorporation	incorporation	NN
cord-022313-2675sjlf	609	26	of	of	IN
cord-022313-2675sjlf	609	27	acetate	acetate	NN
cord-022313-2675sjlf	609	28	into	into	IN
cord-022313-2675sjlf	609	29	cholesterol	cholesterol	NN
cord-022313-2675sjlf	609	30	.	.	.
cord-022313-2675sjlf	610	1	However	however	RB
cord-022313-2675sjlf	610	2	,	,	,
cord-022313-2675sjlf	610	3	it	-PRON-	PRP
cord-022313-2675sjlf	610	4	did	do	VBD
cord-022313-2675sjlf	610	5	not	not	RB
cord-022313-2675sjlf	610	6	increase	increase	VB
cord-022313-2675sjlf	610	7	the	the	DT
cord-022313-2675sjlf	610	8	incorporation	incorporation	NN
cord-022313-2675sjlf	610	9	of	of	IN
cord-022313-2675sjlf	610	10	acetate	acetate	NN
cord-022313-2675sjlf	610	11	into	into	IN
cord-022313-2675sjlf	610	12	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	610	13	-	-	HYPH
cord-022313-2675sjlf	610	14	P	p	NN
cord-022313-2675sjlf	610	15	(	(	-LRB-
cord-022313-2675sjlf	610	16	241	241	CD
cord-022313-2675sjlf	610	17	)	)	-RRB-
cord-022313-2675sjlf	610	18	.	.	.
cord-022313-2675sjlf	611	1	On	on	IN
cord-022313-2675sjlf	611	2	the	the	DT
cord-022313-2675sjlf	611	3	other	other	JJ
cord-022313-2675sjlf	611	4	hand	hand	NN
cord-022313-2675sjlf	611	5	,	,	,
cord-022313-2675sjlf	611	6	feeding	feed	VBG
cord-022313-2675sjlf	611	7	animals	animal	NNS
cord-022313-2675sjlf	611	8	a	a	DT
cord-022313-2675sjlf	611	9	diet	diet	NN
cord-022313-2675sjlf	611	10	high	high	RB
cord-022313-2675sjlf	611	11	in	in	IN
cord-022313-2675sjlf	611	12	cholesterol	cholesterol	NN
cord-022313-2675sjlf	611	13	would	would	MD
cord-022313-2675sjlf	611	14	be	be	VB
cord-022313-2675sjlf	611	15	expected	expect	VBN
cord-022313-2675sjlf	611	16	to	to	TO
cord-022313-2675sjlf	611	17	suppress	suppress	VB
cord-022313-2675sjlf	611	18	cholesterol	cholesterol	NN
cord-022313-2675sjlf	611	19	synthesis	synthesis	NN
cord-022313-2675sjlf	611	20	at	at	IN
cord-022313-2675sjlf	611	21	the	the	DT
cord-022313-2675sjlf	611	22	level	level	NN
cord-022313-2675sjlf	611	23	of	of	IN
cord-022313-2675sjlf	611	24	the	the	DT
cord-022313-2675sjlf	611	25	HMG	HMG	NNP
cord-022313-2675sjlf	611	26	CoA	coa	NN
cord-022313-2675sjlf	611	27	reductase	reductase	NN
cord-022313-2675sjlf	611	28	.	.	.
cord-022313-2675sjlf	612	1	However	however	RB
cord-022313-2675sjlf	612	2	,	,	,
cord-022313-2675sjlf	612	3	this	this	DT
cord-022313-2675sjlf	612	4	treatment	treatment	NN
cord-022313-2675sjlf	612	5	caused	cause	VBD
cord-022313-2675sjlf	612	6	a	a	DT
cord-022313-2675sjlf	612	7	significant	significant	JJ
cord-022313-2675sjlf	612	8	increase	increase	NN
cord-022313-2675sjlf	612	9	in	in	IN
cord-022313-2675sjlf	612	10	the	the	DT
cord-022313-2675sjlf	612	11	incorporation	incorporation	NN
cord-022313-2675sjlf	612	12	of	of	IN
cord-022313-2675sjlf	612	13	mevalonate	mevalonate	NNP
cord-022313-2675sjlf	612	14	into	into	IN
cord-022313-2675sjlf	612	15	dolichol	dolichol	NNP
cord-022313-2675sjlf	612	16	and	and	CC
cord-022313-2675sjlf	612	17	dolichol	dolichol	RB
cord-022313-2675sjlf	612	18	-	-	HYPH
cord-022313-2675sjlf	612	19	linked	link	VBN
cord-022313-2675sjlf	612	20	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	612	21	as	as	RB
cord-022313-2675sjlf	612	22	well	well	RB
cord-022313-2675sjlf	612	23	as	as	IN
cord-022313-2675sjlf	612	24	increased	increase	VBN
cord-022313-2675sjlf	612	25	activity	activity	NN
cord-022313-2675sjlf	612	26	of	of	IN
cord-022313-2675sjlf	612	27	some	some	DT
cord-022313-2675sjlf	612	28	of	of	IN
cord-022313-2675sjlf	612	29	the	the	DT
cord-022313-2675sjlf	612	30	glycosyltransferases	glycosyltransferase	NNS
cord-022313-2675sjlf	612	31	that	that	WDT
cord-022313-2675sjlf	612	32	are	be	VBP
cord-022313-2675sjlf	612	33	required	require	VBN
cord-022313-2675sjlf	612	34	for	for	IN
cord-022313-2675sjlf	612	35	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	612	36	synthesis	synthesis	NN
cord-022313-2675sjlf	612	37	(	(	-LRB-
cord-022313-2675sjlf	612	38	242	242	CD
cord-022313-2675sjlf	612	39	)	)	-RRB-
cord-022313-2675sjlf	612	40	.	.	.
cord-022313-2675sjlf	613	1	The	the	DT
cord-022313-2675sjlf	613	2	explanation	explanation	NN
cord-022313-2675sjlf	613	3	for	for	IN
cord-022313-2675sjlf	613	4	these	these	DT
cord-022313-2675sjlf	613	5	data	datum	NNS
cord-022313-2675sjlf	613	6	is	be	VBZ
cord-022313-2675sjlf	613	7	not	not	RB
cord-022313-2675sjlf	613	8	clear	clear	JJ
cord-022313-2675sjlf	613	9	,	,	,
cord-022313-2675sjlf	613	10	but	but	CC
cord-022313-2675sjlf	613	11	perhaps	perhaps	RB
cord-022313-2675sjlf	613	12	inhibiting	inhibit	VBG
cord-022313-2675sjlf	613	13	the	the	DT
cord-022313-2675sjlf	613	14	cholesterol	cholesterol	NN
cord-022313-2675sjlf	613	15	branch	branch	NN
cord-022313-2675sjlf	613	16	of	of	IN
cord-022313-2675sjlf	613	17	the	the	DT
cord-022313-2675sjlf	613	18	polyprenol	polyprenol	NNP
cord-022313-2675sjlf	613	19	pathway	pathway	NN
cord-022313-2675sjlf	613	20	results	result	NNS
cord-022313-2675sjlf	613	21	in	in	IN
cord-022313-2675sjlf	613	22	the	the	DT
cord-022313-2675sjlf	613	23	accumula	accumula	JJ
cord-022313-2675sjlf	613	24	tion	tion	NN
cord-022313-2675sjlf	613	25	of	of	IN
cord-022313-2675sjlf	613	26	certain	certain	JJ
cord-022313-2675sjlf	613	27	intermediates	intermediate	NNS
cord-022313-2675sjlf	613	28	that	that	WDT
cord-022313-2675sjlf	613	29	are	be	VBP
cord-022313-2675sjlf	613	30	key	key	JJ
cord-022313-2675sjlf	613	31	players	player	NNS
cord-022313-2675sjlf	613	32	in	in	IN
cord-022313-2675sjlf	613	33	other	other	JJ
cord-022313-2675sjlf	613	34	branches	branch	NNS
cord-022313-2675sjlf	613	35	of	of	IN
cord-022313-2675sjlf	613	36	the	the	DT
cord-022313-2675sjlf	613	37	biosynthetic	biosynthetic	JJ
cord-022313-2675sjlf	613	38	pathway	pathway	NN
cord-022313-2675sjlf	613	39	.	.	.
cord-022313-2675sjlf	614	1	Compactin	Compactin	NNP
cord-022313-2675sjlf	614	2	is	be	VBZ
cord-022313-2675sjlf	614	3	a	a	DT
cord-022313-2675sjlf	614	4	fungal	fungal	JJ
cord-022313-2675sjlf	614	5	product	product	NN
cord-022313-2675sjlf	614	6	that	that	WDT
cord-022313-2675sjlf	614	7	is	be	VBZ
cord-022313-2675sjlf	614	8	a	a	DT
cord-022313-2675sjlf	614	9	competitive	competitive	JJ
cord-022313-2675sjlf	614	10	inhibitor	inhibitor	NN
cord-022313-2675sjlf	614	11	of	of	IN
cord-022313-2675sjlf	614	12	HMG	HMG	NNP
cord-022313-2675sjlf	614	13	CoA	coa	NN
cord-022313-2675sjlf	614	14	reductase	reductase	NN
cord-022313-2675sjlf	614	15	(	(	-LRB-
cord-022313-2675sjlf	614	16	243	243	CD
cord-022313-2675sjlf	614	17	)	)	-RRB-
cord-022313-2675sjlf	614	18	.	.	.
cord-022313-2675sjlf	615	1	Compactin	Compactin	NNP
cord-022313-2675sjlf	615	2	,	,	,
cord-022313-2675sjlf	615	3	and	and	CC
cord-022313-2675sjlf	615	4	a	a	DT
cord-022313-2675sjlf	615	5	number	number	NN
cord-022313-2675sjlf	615	6	of	of	IN
cord-022313-2675sjlf	615	7	chemically	chemically	RB
cord-022313-2675sjlf	615	8	synthe	synthe	NNP
cord-022313-2675sjlf	615	9	sized	sized	JJ
cord-022313-2675sjlf	615	10	derivatives	derivative	NNS
cord-022313-2675sjlf	615	11	of	of	IN
cord-022313-2675sjlf	615	12	this	this	DT
cord-022313-2675sjlf	615	13	structure	structure	NN
cord-022313-2675sjlf	615	14	(	(	-LRB-
cord-022313-2675sjlf	615	15	i.e.	i.e.	FW
cord-022313-2675sjlf	615	16	,	,	,
cord-022313-2675sjlf	615	17	mevinolin	mevinolin	NNP
cord-022313-2675sjlf	615	18	)	)	-RRB-
cord-022313-2675sjlf	615	19	,	,	,
cord-022313-2675sjlf	615	20	have	have	VBP
cord-022313-2675sjlf	615	21	been	be	VBN
cord-022313-2675sjlf	615	22	studied	study	VBN
cord-022313-2675sjlf	615	23	extensively	extensively	RB
cord-022313-2675sjlf	615	24	because	because	IN
cord-022313-2675sjlf	615	25	of	of	IN
cord-022313-2675sjlf	615	26	their	-PRON-	PRP$
cord-022313-2675sjlf	615	27	enormous	enormous	JJ
cord-022313-2675sjlf	615	28	chemotherapeutic	chemotherapeutic	JJ
cord-022313-2675sjlf	615	29	potential	potential	NN
cord-022313-2675sjlf	615	30	in	in	IN
cord-022313-2675sjlf	615	31	lowering	lower	VBG
cord-022313-2675sjlf	615	32	serum	serum	NN
cord-022313-2675sjlf	615	33	cholesterol	cholesterol	NN
cord-022313-2675sjlf	615	34	levels	level	NNS
cord-022313-2675sjlf	615	35	.	.	.
cord-022313-2675sjlf	616	1	In	in	IN
cord-022313-2675sjlf	616	2	one	one	CD
cord-022313-2675sjlf	616	3	study	study	NN
cord-022313-2675sjlf	616	4	,	,	,
cord-022313-2675sjlf	616	5	when	when	WRB
cord-022313-2675sjlf	616	6	rat	rat	NN
cord-022313-2675sjlf	616	7	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	616	8	were	be	VBD
cord-022313-2675sjlf	616	9	cultured	culture	VBN
cord-022313-2675sjlf	616	10	in	in	IN
cord-022313-2675sjlf	616	11	compactin	compactin	NNS
cord-022313-2675sjlf	616	12	for	for	IN
cord-022313-2675sjlf	616	13	24	24	CD
cord-022313-2675sjlf	616	14	hr	hr	NN
cord-022313-2675sjlf	616	15	,	,	,
cord-022313-2675sjlf	616	16	the	the	DT
cord-022313-2675sjlf	616	17	synthesis	synthesis	NN
cord-022313-2675sjlf	616	18	of	of	IN
cord-022313-2675sjlf	616	19	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	616	20	-	-	HYPH
cord-022313-2675sjlf	616	21	P	P	NNP
cord-022313-2675sjlf	616	22	was	be	VBD
cord-022313-2675sjlf	616	23	decreased	decrease	VBN
cord-022313-2675sjlf	616	24	by	by	IN
cord-022313-2675sjlf	616	25	75	75	CD
cord-022313-2675sjlf	616	26	-	-	SYM
cord-022313-2675sjlf	616	27	90	90	CD
cord-022313-2675sjlf	616	28	%	%	NN
cord-022313-2675sjlf	616	29	,	,	,
cord-022313-2675sjlf	616	30	suggesting	suggest	VBG
cord-022313-2675sjlf	616	31	that	that	IN
cord-022313-2675sjlf	616	32	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	616	33	-	-	HYPH
cord-022313-2675sjlf	616	34	P	P	NNP
cord-022313-2675sjlf	616	35	was	be	VBD
cord-022313-2675sjlf	616	36	mainly	mainly	RB
cord-022313-2675sjlf	616	37	synthe	synthe	NNP
cord-022313-2675sjlf	616	38	sized	size	VBN
cord-022313-2675sjlf	616	39	by	by	IN
cord-022313-2675sjlf	616	40	the	the	DT
cord-022313-2675sjlf	616	41	de	de	FW
cord-022313-2675sjlf	616	42	novo	novo	NNP
cord-022313-2675sjlf	616	43	pathway	pathway	NNP
cord-022313-2675sjlf	616	44	and	and	CC
cord-022313-2675sjlf	616	45	that	that	IN
cord-022313-2675sjlf	616	46	the	the	DT
cord-022313-2675sjlf	616	47	CTP	CTP	NNP
cord-022313-2675sjlf	616	48	-	-	HYPH
cord-022313-2675sjlf	616	49	mediated	mediate	VBN
cord-022313-2675sjlf	616	50	phosphoryla	phosphoryla	NNP
cord-022313-2675sjlf	616	51	tion	tion	NN
cord-022313-2675sjlf	616	52	of	of	IN
cord-022313-2675sjlf	616	53	dolichol	dolichol	NNP
cord-022313-2675sjlf	616	54	was	be	VBD
cord-022313-2675sjlf	616	55	of	of	IN
cord-022313-2675sjlf	616	56	limited	limit	VBN
cord-022313-2675sjlf	616	57	use	use	NN
cord-022313-2675sjlf	616	58	.	.	.
cord-022313-2675sjlf	617	1	However	however	RB
cord-022313-2675sjlf	617	2	,	,	,
cord-022313-2675sjlf	617	3	another	another	DT
cord-022313-2675sjlf	617	4	study	study	NN
cord-022313-2675sjlf	617	5	(	(	-LRB-
cord-022313-2675sjlf	617	6	244	244	CD
cord-022313-2675sjlf	617	7	)	)	-RRB-
cord-022313-2675sjlf	617	8	indi	indi	NNP
cord-022313-2675sjlf	617	9	cated	cat	VBD
cord-022313-2675sjlf	617	10	that	that	IN
cord-022313-2675sjlf	617	11	the	the	DT
cord-022313-2675sjlf	617	12	dolichol	dolichol	NNP
cord-022313-2675sjlf	617	13	kinase	kinase	NN
cord-022313-2675sjlf	617	14	and	and	CC
cord-022313-2675sjlf	617	15	the	the	DT
cord-022313-2675sjlf	617	16	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	617	17	-	-	HYPH
cord-022313-2675sjlf	617	18	P	p	NN
cord-022313-2675sjlf	617	19	phosphatase	phosphatase	NN
cord-022313-2675sjlf	617	20	played	play	VBD
cord-022313-2675sjlf	617	21	key	key	JJ
cord-022313-2675sjlf	617	22	roles	role	NNS
cord-022313-2675sjlf	617	23	in	in	IN
cord-022313-2675sjlf	617	24	regulating	regulate	VBG
cord-022313-2675sjlf	617	25	the	the	DT
cord-022313-2675sjlf	617	26	cellular	cellular	JJ
cord-022313-2675sjlf	617	27	levels	level	NNS
cord-022313-2675sjlf	617	28	of	of	IN
cord-022313-2675sjlf	617	29	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	618	1	-P.	-P.	NNS
cord-022313-2675sjlf	618	2	When	when	WRB
cord-022313-2675sjlf	618	3	com	com	NN
cord-022313-2675sjlf	618	4	pactin	pactin	NN
cord-022313-2675sjlf	618	5	,	,	,
cord-022313-2675sjlf	618	6	at	at	IN
cord-022313-2675sjlf	618	7	concentrations	concentration	NNS
cord-022313-2675sjlf	618	8	of	of	IN
cord-022313-2675sjlf	618	9	1	1	CD
cord-022313-2675sjlf	618	10	-	-	SYM
cord-022313-2675sjlf	618	11	5	5	CD
cord-022313-2675sjlf	619	1	μΜ	μΜ	NNP
cord-022313-2675sjlf	619	2	,	,	,
cord-022313-2675sjlf	619	3	was	be	VBD
cord-022313-2675sjlf	619	4	fed	feed	VBN
cord-022313-2675sjlf	619	5	to	to	IN
cord-022313-2675sjlf	619	6	sea	sea	NN
cord-022313-2675sjlf	619	7	urchin	urchin	NN
cord-022313-2675sjlf	619	8	embryos	embryo	NNS
cord-022313-2675sjlf	619	9	,	,	,
cord-022313-2675sjlf	619	10	it	-PRON-	PRP
cord-022313-2675sjlf	619	11	induced	induce	VBD
cord-022313-2675sjlf	619	12	abnormal	abnormal	JJ
cord-022313-2675sjlf	619	13	gastrulation	gastrulation	NN
cord-022313-2675sjlf	619	14	.	.	.
cord-022313-2675sjlf	620	1	This	this	DT
cord-022313-2675sjlf	620	2	effect	effect	NN
cord-022313-2675sjlf	620	3	appeared	appear	VBD
cord-022313-2675sjlf	620	4	to	to	TO
cord-022313-2675sjlf	620	5	be	be	VB
cord-022313-2675sjlf	620	6	due	due	JJ
cord-022313-2675sjlf	620	7	to	to	IN
cord-022313-2675sjlf	620	8	an	an	DT
cord-022313-2675sjlf	620	9	inhibition	inhibition	NN
cord-022313-2675sjlf	620	10	in	in	IN
cord-022313-2675sjlf	620	11	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	620	12	-	-	HYPH
cord-022313-2675sjlf	620	13	P	p	NN
cord-022313-2675sjlf	620	14	formation	formation	NN
cord-022313-2675sjlf	620	15	because	because	IN
cord-022313-2675sjlf	620	16	these	these	DT
cord-022313-2675sjlf	620	17	embryos	embryo	NNS
cord-022313-2675sjlf	620	18	also	also	RB
cord-022313-2675sjlf	620	19	showed	show	VBD
cord-022313-2675sjlf	620	20	a	a	DT
cord-022313-2675sjlf	620	21	decreased	decrease	VBN
cord-022313-2675sjlf	620	22	capacity	capacity	NN
cord-022313-2675sjlf	620	23	to	to	TO
cord-022313-2675sjlf	620	24	synthesize	synthesize	VB
cord-022313-2675sjlf	620	25	lipid	lipid	NN
cord-022313-2675sjlf	620	26	-	-	HYPH
cord-022313-2675sjlf	620	27	linked	link	VBN
cord-022313-2675sjlf	620	28	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	620	29	and	and	CC
cord-022313-2675sjlf	620	30	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	620	31	.	.	.
cord-022313-2675sjlf	621	1	Furthermore	furthermore	RB
cord-022313-2675sjlf	621	2	the	the	DT
cord-022313-2675sjlf	621	3	inhibitory	inhibitory	JJ
cord-022313-2675sjlf	621	4	effect	effect	NN
cord-022313-2675sjlf	621	5	of	of	IN
cord-022313-2675sjlf	621	6	compactin	compactin	NNS
cord-022313-2675sjlf	621	7	on	on	IN
cord-022313-2675sjlf	621	8	devel	devel	NN
cord-022313-2675sjlf	621	9	opment	opment	NN
cord-022313-2675sjlf	621	10	could	could	MD
cord-022313-2675sjlf	621	11	be	be	VB
cord-022313-2675sjlf	621	12	overcome	overcome	VBN
cord-022313-2675sjlf	621	13	by	by	IN
cord-022313-2675sjlf	621	14	supplementing	supplement	VBG
cord-022313-2675sjlf	621	15	the	the	DT
cord-022313-2675sjlf	621	16	embryos	embryo	NNS
cord-022313-2675sjlf	621	17	with	with	IN
cord-022313-2675sjlf	621	18	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	621	19	-	-	HYPH
cord-022313-2675sjlf	621	20	P	p	NN
cord-022313-2675sjlf	621	21	,	,	,
cord-022313-2675sjlf	621	22	but	but	CC
cord-022313-2675sjlf	621	23	the	the	DT
cord-022313-2675sjlf	621	24	addition	addition	NN
cord-022313-2675sjlf	621	25	of	of	IN
cord-022313-2675sjlf	621	26	cholesterol	cholesterol	NN
cord-022313-2675sjlf	621	27	or	or	CC
cord-022313-2675sjlf	621	28	coenzyme	coenzyme	NN
cord-022313-2675sjlf	621	29	Q	Q	NNP
cord-022313-2675sjlf	621	30	could	could	MD
cord-022313-2675sjlf	621	31	not	not	RB
cord-022313-2675sjlf	621	32	overcome	overcome	VB
cord-022313-2675sjlf	621	33	the	the	DT
cord-022313-2675sjlf	621	34	inhibition	inhibition	NN
cord-022313-2675sjlf	621	35	(	(	-LRB-
cord-022313-2675sjlf	621	36	245	245	CD
cord-022313-2675sjlf	621	37	)	)	-RRB-
cord-022313-2675sjlf	621	38	.	.	.
cord-022313-2675sjlf	622	1	Similar	similar	JJ
cord-022313-2675sjlf	622	2	results	result	NNS
cord-022313-2675sjlf	622	3	were	be	VBD
cord-022313-2675sjlf	622	4	obtained	obtain	VBN
cord-022313-2675sjlf	622	5	with	with	IN
cord-022313-2675sjlf	622	6	mouse	mouse	NN
cord-022313-2675sjlf	622	7	embryos	embryo	NNS
cord-022313-2675sjlf	622	8	,	,	,
cord-022313-2675sjlf	622	9	in	in	IN
cord-022313-2675sjlf	622	10	which	which	WDT
cord-022313-2675sjlf	622	11	compactin	compactin	NNP
cord-022313-2675sjlf	622	12	and	and	CC
cord-022313-2675sjlf	622	13	an	an	DT
cord-022313-2675sjlf	622	14	oxygenated	oxygenated	JJ
cord-022313-2675sjlf	622	15	sterol	sterol	NN
cord-022313-2675sjlf	622	16	arrested	arrest	VBN
cord-022313-2675sjlf	622	17	development	development	NN
cord-022313-2675sjlf	622	18	at	at	IN
cord-022313-2675sjlf	622	19	the	the	DT
cord-022313-2675sjlf	622	20	32-cell	32-cell	CD
cord-022313-2675sjlf	622	21	stage	stage	NN
cord-022313-2675sjlf	622	22	and	and	CC
cord-022313-2675sjlf	622	23	left	leave	VBD
cord-022313-2675sjlf	622	24	the	the	DT
cord-022313-2675sjlf	622	25	blastomeres	blastomere	NNS
cord-022313-2675sjlf	622	26	decompacted	decompacte	VBN
cord-022313-2675sjlf	622	27	.	.	.
cord-022313-2675sjlf	623	1	Here	here	RB
cord-022313-2675sjlf	623	2	also	also	RB
cord-022313-2675sjlf	623	3	,	,	,
cord-022313-2675sjlf	623	4	Nglycosylation	Nglycosylation	NNP
cord-022313-2675sjlf	623	5	was	be	VBD
cord-022313-2675sjlf	623	6	effected	effect	VBN
cord-022313-2675sjlf	623	7	and	and	CC
cord-022313-2675sjlf	623	8	this	this	DT
cord-022313-2675sjlf	623	9	affect	affect	NN
cord-022313-2675sjlf	623	10	could	could	MD
cord-022313-2675sjlf	623	11	be	be	VB
cord-022313-2675sjlf	623	12	overcome	overcome	VBN
cord-022313-2675sjlf	623	13	by	by	IN
cord-022313-2675sjlf	623	14	adding	add	VBG
cord-022313-2675sjlf	623	15	mevalonate	mevalonate	NNP
cord-022313-2675sjlf	623	16	(	(	-LRB-
cord-022313-2675sjlf	623	17	246	246	CD
cord-022313-2675sjlf	623	18	)	)	-RRB-
cord-022313-2675sjlf	623	19	.	.	.
cord-022313-2675sjlf	624	1	During	during	IN
cord-022313-2675sjlf	624	2	their	-PRON-	PRP$
cord-022313-2675sjlf	624	3	synthesis	synthesis	NN
cord-022313-2675sjlf	624	4	and	and	CC
cord-022313-2675sjlf	624	5	processing	processing	NN
cord-022313-2675sjlf	624	6	,	,	,
cord-022313-2675sjlf	624	7	the	the	DT
cord-022313-2675sjlf	624	8	N	n	NN
cord-022313-2675sjlf	624	9	-	-	HYPH
cord-022313-2675sjlf	624	10	linked	link	VBN
cord-022313-2675sjlf	624	11	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	624	12	are	be	VBP
cord-022313-2675sjlf	624	13	transported	transport	VBN
cord-022313-2675sjlf	624	14	from	from	IN
cord-022313-2675sjlf	624	15	the	the	DT
cord-022313-2675sjlf	624	16	initial	initial	JJ
cord-022313-2675sjlf	624	17	site	site	NN
cord-022313-2675sjlf	624	18	of	of	IN
cord-022313-2675sjlf	624	19	synthesis	synthesis	NN
cord-022313-2675sjlf	624	20	in	in	IN
cord-022313-2675sjlf	624	21	the	the	DT
cord-022313-2675sjlf	624	22	endoplasmic	endoplasmic	NN
cord-022313-2675sjlf	624	23	reticulum	reticulum	NN
cord-022313-2675sjlf	624	24	of	of	IN
cord-022313-2675sjlf	624	25	the	the	DT
cord-022313-2675sjlf	624	26	cell	cell	NN
cord-022313-2675sjlf	624	27	through	through	IN
cord-022313-2675sjlf	624	28	the	the	DT
cord-022313-2675sjlf	624	29	various	various	JJ
cord-022313-2675sjlf	624	30	Golgi	Golgi	NNP
cord-022313-2675sjlf	624	31	stacks	stack	NNS
cord-022313-2675sjlf	624	32	(	(	-LRB-
cord-022313-2675sjlf	624	33	i.e.	i.e.	FW
cord-022313-2675sjlf	624	34	,	,	,
cord-022313-2675sjlf	624	35	from	from	IN
cord-022313-2675sjlf	624	36	cis	cis	NNP
cord-022313-2675sjlf	624	37	-	-	HYPH
cord-022313-2675sjlf	624	38	Golgi	Golgi	NNP
cord-022313-2675sjlf	624	39	,	,	,
cord-022313-2675sjlf	624	40	through	through	IN
cord-022313-2675sjlf	624	41	medial	medial	JJ
cord-022313-2675sjlf	624	42	Golgi	Golgi	NNP
cord-022313-2675sjlf	624	43	,	,	,
cord-022313-2675sjlf	624	44	to	to	IN
cord-022313-2675sjlf	624	45	trans	trans	NNP
cord-022313-2675sjlf	624	46	-	-	NNP
cord-022313-2675sjlf	624	47	Golgi	Golgi	NNP
cord-022313-2675sjlf	624	48	)	)	-RRB-
cord-022313-2675sjlf	624	49	to	to	IN
cord-022313-2675sjlf	624	50	their	-PRON-	PRP$
cord-022313-2675sjlf	624	51	final	final	JJ
cord-022313-2675sjlf	624	52	destination	destination	NN
cord-022313-2675sjlf	624	53	in	in	IN
cord-022313-2675sjlf	624	54	the	the	DT
cord-022313-2675sjlf	624	55	plasma	plasma	NN
cord-022313-2675sjlf	624	56	membranes	membrane	NNS
cord-022313-2675sjlf	624	57	,	,	,
cord-022313-2675sjlf	624	58	in	in	IN
cord-022313-2675sjlf	624	59	lysosomes	lysosome	NNS
cord-022313-2675sjlf	624	60	or	or	CC
cord-022313-2675sjlf	624	61	in	in	IN
cord-022313-2675sjlf	624	62	other	other	JJ
cord-022313-2675sjlf	624	63	locations	location	NNS
cord-022313-2675sjlf	624	64	in	in	IN
cord-022313-2675sjlf	624	65	the	the	DT
cord-022313-2675sjlf	624	66	cell	cell	NN
cord-022313-2675sjlf	624	67	.	.	.
cord-022313-2675sjlf	625	1	While	while	IN
cord-022313-2675sjlf	625	2	the	the	DT
cord-022313-2675sjlf	625	3	signals	signal	NNS
cord-022313-2675sjlf	625	4	that	that	WDT
cord-022313-2675sjlf	625	5	direct	direct	VBP
cord-022313-2675sjlf	625	6	these	these	DT
cord-022313-2675sjlf	625	7	proteins	protein	NNS
cord-022313-2675sjlf	625	8	to	to	IN
cord-022313-2675sjlf	625	9	specific	specific	JJ
cord-022313-2675sjlf	625	10	sites	site	NNS
cord-022313-2675sjlf	625	11	are	be	VBP
cord-022313-2675sjlf	625	12	known	know	VBN
cord-022313-2675sjlf	625	13	in	in	IN
cord-022313-2675sjlf	625	14	some	some	DT
cord-022313-2675sjlf	625	15	cases	case	NNS
cord-022313-2675sjlf	625	16	(	(	-LRB-
cord-022313-2675sjlf	625	17	e.g.	e.g.	RB
cord-022313-2675sjlf	625	18	,	,	,
cord-022313-2675sjlf	625	19	the	the	DT
cord-022313-2675sjlf	625	20	mannose-6-phosphate	mannose-6-phosphate	NNP
cord-022313-2675sjlf	625	21	receptor	receptor	NN
cord-022313-2675sjlf	625	22	for	for	IN
cord-022313-2675sjlf	625	23	lyso	lyso	NNP
cord-022313-2675sjlf	625	24	somal	somal	NNP
cord-022313-2675sjlf	625	25	targeting	targeting	NN
cord-022313-2675sjlf	625	26	has	have	VBZ
cord-022313-2675sjlf	625	27	been	be	VBN
cord-022313-2675sjlf	625	28	elegantly	elegantly	RB
cord-022313-2675sjlf	625	29	described	describe	VBN
cord-022313-2675sjlf	625	30	(	(	-LRB-
cord-022313-2675sjlf	625	31	247	247	CD
cord-022313-2675sjlf	625	32	)	)	-RRB-
cord-022313-2675sjlf	625	33	)	)	-RRB-
cord-022313-2675sjlf	625	34	,	,	,
cord-022313-2675sjlf	625	35	in	in	IN
cord-022313-2675sjlf	625	36	other	other	JJ
cord-022313-2675sjlf	625	37	cases	case	NNS
cord-022313-2675sjlf	625	38	the	the	DT
cord-022313-2675sjlf	625	39	signals	signal	NNS
cord-022313-2675sjlf	625	40	are	be	VBP
cord-022313-2675sjlf	625	41	just	just	RB
cord-022313-2675sjlf	625	42	beginning	begin	VBG
cord-022313-2675sjlf	625	43	to	to	TO
cord-022313-2675sjlf	625	44	become	become	VB
cord-022313-2675sjlf	625	45	known	know	VBN
cord-022313-2675sjlf	625	46	.	.	.
cord-022313-2675sjlf	626	1	Nevertheless	nevertheless	RB
cord-022313-2675sjlf	626	2	,	,	,
cord-022313-2675sjlf	626	3	a	a	DT
cord-022313-2675sjlf	626	4	number	number	NN
cord-022313-2675sjlf	626	5	of	of	IN
cord-022313-2675sjlf	626	6	compounds	compound	NNS
cord-022313-2675sjlf	626	7	have	have	VBP
cord-022313-2675sjlf	626	8	been	be	VBN
cord-022313-2675sjlf	626	9	identified	identify	VBN
cord-022313-2675sjlf	626	10	that	that	WDT
cord-022313-2675sjlf	626	11	perturb	perturb	VBP
cord-022313-2675sjlf	626	12	the	the	DT
cord-022313-2675sjlf	626	13	transport	transport	NN
cord-022313-2675sjlf	626	14	or	or	CC
cord-022313-2675sjlf	626	15	migra	migra	NNP
cord-022313-2675sjlf	626	16	tion	tion	NN
cord-022313-2675sjlf	626	17	of	of	IN
cord-022313-2675sjlf	626	18	proteins	protein	NNS
cord-022313-2675sjlf	626	19	through	through	IN
cord-022313-2675sjlf	626	20	the	the	DT
cord-022313-2675sjlf	626	21	various	various	JJ
cord-022313-2675sjlf	626	22	compartments	compartment	NNS
cord-022313-2675sjlf	626	23	of	of	IN
cord-022313-2675sjlf	626	24	the	the	DT
cord-022313-2675sjlf	626	25	cell	cell	NN
cord-022313-2675sjlf	626	26	.	.	.
cord-022313-2675sjlf	627	1	Most	Most	JJS
cord-022313-2675sjlf	627	2	of	of	IN
cord-022313-2675sjlf	627	3	these	these	DT
cord-022313-2675sjlf	627	4	pertubants	pertubant	NNS
cord-022313-2675sjlf	627	5	are	be	VBP
cord-022313-2675sjlf	627	6	ionophores	ionophore	NNS
cord-022313-2675sjlf	627	7	that	that	WDT
cord-022313-2675sjlf	627	8	affect	affect	VBP
cord-022313-2675sjlf	627	9	the	the	DT
cord-022313-2675sjlf	627	10	concentrations	concentration	NNS
cord-022313-2675sjlf	627	11	of	of	IN
cord-022313-2675sjlf	627	12	vari	vari	FW
cord-022313-2675sjlf	627	13	ous	ous	JJ
cord-022313-2675sjlf	627	14	ions	ion	NNS
cord-022313-2675sjlf	627	15	in	in	IN
cord-022313-2675sjlf	627	16	some	some	DT
cord-022313-2675sjlf	627	17	cellular	cellular	JJ
cord-022313-2675sjlf	627	18	compartments	compartment	NNS
cord-022313-2675sjlf	627	19	and	and	CC
cord-022313-2675sjlf	627	20	may	may	MD
cord-022313-2675sjlf	627	21	also	also	RB
cord-022313-2675sjlf	627	22	affect	affect	VB
cord-022313-2675sjlf	627	23	the	the	DT
cord-022313-2675sjlf	627	24	internal	internal	JJ
cord-022313-2675sjlf	627	25	pH	ph	NN
cord-022313-2675sjlf	627	26	of	of	IN
cord-022313-2675sjlf	627	27	these	these	DT
cord-022313-2675sjlf	627	28	compartments	compartment	NNS
cord-022313-2675sjlf	627	29	.	.	.
cord-022313-2675sjlf	628	1	For	for	IN
cord-022313-2675sjlf	628	2	example	example	NN
cord-022313-2675sjlf	628	3	,	,	,
cord-022313-2675sjlf	628	4	the	the	DT
cord-022313-2675sjlf	628	5	secretion	secretion	NN
cord-022313-2675sjlf	628	6	of	of	IN
cord-022313-2675sjlf	628	7	immunoglobu	immunoglobu	NNP
cord-022313-2675sjlf	628	8	lins	lins	NNP
cord-022313-2675sjlf	628	9	by	by	IN
cord-022313-2675sjlf	628	10	plasma	plasma	NN
cord-022313-2675sjlf	628	11	cells	cell	NNS
cord-022313-2675sjlf	628	12	was	be	VBD
cord-022313-2675sjlf	628	13	markedly	markedly	RB
cord-022313-2675sjlf	628	14	inhibited	inhibit	VBN
cord-022313-2675sjlf	628	15	by	by	IN
cord-022313-2675sjlf	628	16	monensin	monensin	NNP
cord-022313-2675sjlf	628	17	,	,	,
cord-022313-2675sjlf	628	18	and	and	CC
cord-022313-2675sjlf	628	19	striking	striking	JJ
cord-022313-2675sjlf	628	20	alterations	alteration	NNS
cord-022313-2675sjlf	628	21	in	in	IN
cord-022313-2675sjlf	628	22	the	the	DT
cord-022313-2675sjlf	628	23	ultrastructural	ultrastructural	JJ
cord-022313-2675sjlf	628	24	appearance	appearance	NN
cord-022313-2675sjlf	628	25	of	of	IN
cord-022313-2675sjlf	628	26	the	the	DT
cord-022313-2675sjlf	628	27	Golgi	Golgi	NNP
cord-022313-2675sjlf	628	28	apparatus	apparatus	NN
cord-022313-2675sjlf	628	29	were	be	VBD
cord-022313-2675sjlf	628	30	seen	see	VBN
cord-022313-2675sjlf	628	31	(	(	-LRB-
cord-022313-2675sjlf	628	32	248	248	CD
cord-022313-2675sjlf	628	33	)	)	-RRB-
cord-022313-2675sjlf	628	34	.	.	.
cord-022313-2675sjlf	629	1	The	the	DT
cord-022313-2675sjlf	629	2	suggestion	suggestion	NN
cord-022313-2675sjlf	629	3	was	be	VBD
cord-022313-2675sjlf	629	4	made	make	VBN
cord-022313-2675sjlf	629	5	that	that	DT
cord-022313-2675sjlf	629	6	depletion	depletion	NN
cord-022313-2675sjlf	629	7	of	of	IN
cord-022313-2675sjlf	629	8	Ca	Ca	NNP
cord-022313-2675sjlf	629	9	2	2	CD
cord-022313-2675sjlf	629	10	+	+	SYM
cord-022313-2675sjlf	629	11	levels	level	NNS
cord-022313-2675sjlf	629	12	by	by	IN
cord-022313-2675sjlf	629	13	this	this	DT
cord-022313-2675sjlf	629	14	ionophore	ionophore	NN
cord-022313-2675sjlf	629	15	rendered	render	VBD
cord-022313-2675sjlf	629	16	the	the	DT
cord-022313-2675sjlf	629	17	Golgi	Golgi	NNP
cord-022313-2675sjlf	629	18	vesicles	vesicle	NNS
cord-022313-2675sjlf	629	19	incapable	incapable	JJ
cord-022313-2675sjlf	629	20	of	of	IN
cord-022313-2675sjlf	629	21	fusing	fusing	NN
cord-022313-2675sjlf	629	22	,	,	,
cord-022313-2675sjlf	629	23	which	which	WDT
cord-022313-2675sjlf	629	24	resulted	result	VBD
cord-022313-2675sjlf	629	25	in	in	IN
cord-022313-2675sjlf	629	26	a	a	DT
cord-022313-2675sjlf	629	27	disruption	disruption	NN
cord-022313-2675sjlf	629	28	in	in	IN
cord-022313-2675sjlf	629	29	the	the	DT
cord-022313-2675sjlf	629	30	flow	flow	NN
cord-022313-2675sjlf	629	31	of	of	IN
cord-022313-2675sjlf	629	32	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	629	33	from	from	IN
cord-022313-2675sjlf	629	34	the	the	DT
cord-022313-2675sjlf	629	35	ER	ER	NNP
cord-022313-2675sjlf	629	36	to	to	IN
cord-022313-2675sjlf	629	37	the	the	DT
cord-022313-2675sjlf	629	38	Golgi	Golgi	NNP
cord-022313-2675sjlf	629	39	(	(	-LRB-
cord-022313-2675sjlf	629	40	249	249	CD
cord-022313-2675sjlf	629	41	)	)	-RRB-
cord-022313-2675sjlf	629	42	.	.	.
cord-022313-2675sjlf	630	1	The	the	DT
cord-022313-2675sjlf	630	2	transport	transport	NN
cord-022313-2675sjlf	630	3	of	of	IN
cord-022313-2675sjlf	630	4	other	other	JJ
cord-022313-2675sjlf	630	5	proteins	protein	NNS
cord-022313-2675sjlf	630	6	,	,	,
cord-022313-2675sjlf	630	7	such	such	JJ
cord-022313-2675sjlf	630	8	as	as	IN
cord-022313-2675sjlf	630	9	fibronectin	fibronectin	NN
cord-022313-2675sjlf	630	10	and	and	CC
cord-022313-2675sjlf	630	11	procollagen	procollagen	NNP
cord-022313-2675sjlf	630	12	,	,	,
cord-022313-2675sjlf	630	13	is	be	VBZ
cord-022313-2675sjlf	630	14	also	also	RB
cord-022313-2675sjlf	630	15	inhibited	inhibit	VBN
cord-022313-2675sjlf	630	16	by	by	IN
cord-022313-2675sjlf	630	17	ionophores	ionophores	NNP
cord-022313-2675sjlf	630	18	(	(	-LRB-
cord-022313-2675sjlf	630	19	250	250	CD
cord-022313-2675sjlf	630	20	)	)	-RRB-
cord-022313-2675sjlf	630	21	,	,	,
cord-022313-2675sjlf	630	22	as	as	IN
cord-022313-2675sjlf	630	23	is	be	VBZ
cord-022313-2675sjlf	630	24	the	the	DT
cord-022313-2675sjlf	630	25	transport	transport	NN
cord-022313-2675sjlf	630	26	of	of	IN
cord-022313-2675sjlf	630	27	various	various	JJ
cord-022313-2675sjlf	630	28	viral	viral	JJ
cord-022313-2675sjlf	630	29	envelope	envelope	NN
cord-022313-2675sjlf	630	30	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	630	31	(	(	-LRB-
cord-022313-2675sjlf	630	32	251	251	CD
cord-022313-2675sjlf	630	33	)	)	-RRB-
cord-022313-2675sjlf	630	34	.	.	.
cord-022313-2675sjlf	631	1	In	in	IN
cord-022313-2675sjlf	631	2	these	these	DT
cord-022313-2675sjlf	631	3	experiments	experiment	NNS
cord-022313-2675sjlf	631	4	,	,	,
cord-022313-2675sjlf	631	5	membrane	membrane	NN
cord-022313-2675sjlf	631	6	vacuoles	vacuole	NNS
cord-022313-2675sjlf	631	7	could	could	MD
cord-022313-2675sjlf	631	8	be	be	VB
cord-022313-2675sjlf	631	9	visualized	visualize	VBN
cord-022313-2675sjlf	631	10	by	by	IN
cord-022313-2675sjlf	631	11	electron	electron	NN
cord-022313-2675sjlf	631	12	microscopy	microscopy	NN
cord-022313-2675sjlf	631	13	,	,	,
cord-022313-2675sjlf	631	14	and	and	CC
cord-022313-2675sjlf	631	15	large	large	JJ
cord-022313-2675sjlf	631	16	accumulations	accumulation	NNS
cord-022313-2675sjlf	631	17	of	of	IN
cord-022313-2675sjlf	631	18	procollagen	procollagen	NN
cord-022313-2675sjlf	631	19	and	and	CC
cord-022313-2675sjlf	631	20	fibronectin	fibronectin	NN
cord-022313-2675sjlf	631	21	could	could	MD
cord-022313-2675sjlf	631	22	be	be	VB
cord-022313-2675sjlf	631	23	seen	see	VBN
cord-022313-2675sjlf	631	24	in	in	IN
cord-022313-2675sjlf	631	25	these	these	DT
cord-022313-2675sjlf	631	26	vacuoles	vacuole	NNS
cord-022313-2675sjlf	631	27	by	by	IN
cord-022313-2675sjlf	631	28	immunofluoresence	immunofluoresence	NN
cord-022313-2675sjlf	631	29	.	.	.
cord-022313-2675sjlf	632	1	In	in	IN
cord-022313-2675sjlf	632	2	one	one	CD
cord-022313-2675sjlf	632	3	interesting	interesting	JJ
cord-022313-2675sjlf	632	4	study	study	NN
cord-022313-2675sjlf	632	5	,	,	,
cord-022313-2675sjlf	632	6	monensin	monensin	NNP
cord-022313-2675sjlf	632	7	was	be	VBD
cord-022313-2675sjlf	632	8	used	use	VBN
cord-022313-2675sjlf	632	9	as	as	IN
cord-022313-2675sjlf	632	10	a	a	DT
cord-022313-2675sjlf	632	11	tool	tool	NN
cord-022313-2675sjlf	632	12	to	to	TO
cord-022313-2675sjlf	632	13	isolate	isolate	VB
cord-022313-2675sjlf	632	14	those	those	DT
cord-022313-2675sjlf	632	15	cisternae	cisternae	NNP
cord-022313-2675sjlf	632	16	that	that	WDT
cord-022313-2675sjlf	632	17	contained	contain	VBD
cord-022313-2675sjlf	632	18	accumulations	accumulation	NNS
cord-022313-2675sjlf	632	19	of	of	IN
cord-022313-2675sjlf	632	20	viral	viral	JJ
cord-022313-2675sjlf	632	21	capsids	capsid	NNS
cord-022313-2675sjlf	632	22	because	because	IN
cord-022313-2675sjlf	632	23	they	-PRON-	PRP
cord-022313-2675sjlf	632	24	sedimented	sediment	VBD
cord-022313-2675sjlf	632	25	at	at	IN
cord-022313-2675sjlf	632	26	a	a	DT
cord-022313-2675sjlf	632	27	higher	high	JJR
cord-022313-2675sjlf	632	28	density	density	NN
cord-022313-2675sjlf	632	29	that	that	WDT
cord-022313-2675sjlf	632	30	normal	normal	JJ
cord-022313-2675sjlf	632	31	cisternae	cisternae	NN
cord-022313-2675sjlf	632	32	(	(	-LRB-
cord-022313-2675sjlf	632	33	252	252	CD
cord-022313-2675sjlf	632	34	)	)	-RRB-
cord-022313-2675sjlf	632	35	.	.	.
cord-022313-2675sjlf	633	1	In	in	IN
cord-022313-2675sjlf	633	2	the	the	DT
cord-022313-2675sjlf	633	3	presence	presence	NN
cord-022313-2675sjlf	633	4	of	of	IN
cord-022313-2675sjlf	633	5	monensin	monensin	NNP
cord-022313-2675sjlf	633	6	,	,	,
cord-022313-2675sjlf	633	7	terminal	terminal	JJ
cord-022313-2675sjlf	633	8	glycosylation	glycosylation	NN
cord-022313-2675sjlf	633	9	is	be	VBZ
cord-022313-2675sjlf	633	10	inhibited	inhibit	VBN
cord-022313-2675sjlf	633	11	,	,	,
cord-022313-2675sjlf	633	12	i.e.	i.e.	FW
cord-022313-2675sjlf	633	13	,	,	,
cord-022313-2675sjlf	633	14	addition	addition	NN
cord-022313-2675sjlf	633	15	of	of	IN
cord-022313-2675sjlf	633	16	complex	complex	JJ
cord-022313-2675sjlf	633	17	sugars	sugar	NNS
cord-022313-2675sjlf	633	18	such	such	JJ
cord-022313-2675sjlf	633	19	as	as	IN
cord-022313-2675sjlf	633	20	galactose	galactose	NN
cord-022313-2675sjlf	633	21	,	,	,
cord-022313-2675sjlf	633	22	sialic	sialic	NN
cord-022313-2675sjlf	633	23	acid	acid	NN
cord-022313-2675sjlf	633	24	,	,	,
cord-022313-2675sjlf	633	25	fucose	fucose	NNP
cord-022313-2675sjlf	633	26	,	,	,
cord-022313-2675sjlf	633	27	etc	etc	FW
cord-022313-2675sjlf	633	28	.	.	FW
cord-022313-2675sjlf	633	29	,	,	,
cord-022313-2675sjlf	633	30	but	but	CC
cord-022313-2675sjlf	633	31	the	the	DT
cord-022313-2675sjlf	633	32	incorporation	incorporation	NN
cord-022313-2675sjlf	633	33	of	of	IN
cord-022313-2675sjlf	633	34	amino	amino	JJ
cord-022313-2675sjlf	633	35	acids	acid	NNS
cord-022313-2675sjlf	633	36	into	into	IN
cord-022313-2675sjlf	633	37	protein	protein	NN
cord-022313-2675sjlf	633	38	and	and	CC
cord-022313-2675sjlf	633	39	the	the	DT
cord-022313-2675sjlf	633	40	hydroxylation	hydroxylation	NN
cord-022313-2675sjlf	633	41	of	of	IN
cord-022313-2675sjlf	633	42	proline	proline	NN
cord-022313-2675sjlf	633	43	were	be	VBD
cord-022313-2675sjlf	633	44	not	not	RB
cord-022313-2675sjlf	633	45	affected	affect	VBN
cord-022313-2675sjlf	633	46	.	.	.
cord-022313-2675sjlf	634	1	Thus	thus	RB
cord-022313-2675sjlf	634	2	,	,	,
cord-022313-2675sjlf	634	3	in	in	IN
cord-022313-2675sjlf	634	4	monensin	monensin	NNP
cord-022313-2675sjlf	634	5	-	-	HYPH
cord-022313-2675sjlf	634	6	treated	treat	VBN
cord-022313-2675sjlf	634	7	cells	cell	NNS
cord-022313-2675sjlf	634	8	,	,	,
cord-022313-2675sjlf	634	9	newly	newly	RB
cord-022313-2675sjlf	634	10	synthesized	synthesize	VBN
cord-022313-2675sjlf	634	11	proteins	protein	NNS
cord-022313-2675sjlf	634	12	accumulate	accumulate	VBP
cord-022313-2675sjlf	634	13	in	in	IN
cord-022313-2675sjlf	634	14	intracellular	intracellular	JJ
cord-022313-2675sjlf	634	15	vesicles	vesicle	NNS
cord-022313-2675sjlf	634	16	that	that	WDT
cord-022313-2675sjlf	634	17	appear	appear	VBP
cord-022313-2675sjlf	634	18	to	to	TO
cord-022313-2675sjlf	634	19	be	be	VB
cord-022313-2675sjlf	634	20	derived	derive	VBN
cord-022313-2675sjlf	634	21	from	from	IN
cord-022313-2675sjlf	634	22	the	the	DT
cord-022313-2675sjlf	634	23	Golgi	Golgi	NNP
cord-022313-2675sjlf	634	24	apparatus	apparatus	NN
cord-022313-2675sjlf	634	25	,	,	,
cord-022313-2675sjlf	634	26	and	and	CC
cord-022313-2675sjlf	634	27	some	some	DT
cord-022313-2675sjlf	634	28	of	of	IN
cord-022313-2675sjlf	634	29	the	the	DT
cord-022313-2675sjlf	634	30	posttranslational	posttranslational	JJ
cord-022313-2675sjlf	634	31	modifications	modification	NNS
cord-022313-2675sjlf	634	32	are	be	VBP
cord-022313-2675sjlf	634	33	blocked	block	VBN
cord-022313-2675sjlf	634	34	.	.	.
cord-022313-2675sjlf	635	1	Apparantly	apparantly	RB
cord-022313-2675sjlf	635	2	there	there	EX
cord-022313-2675sjlf	635	3	exists	exist	VBZ
cord-022313-2675sjlf	635	4	an	an	DT
cord-022313-2675sjlf	635	5	acidic	acidic	JJ
cord-022313-2675sjlf	635	6	compartment	compartment	NN
cord-022313-2675sjlf	635	7	in	in	IN
cord-022313-2675sjlf	635	8	the	the	DT
cord-022313-2675sjlf	635	9	Golgi	Golgi	NNP
cord-022313-2675sjlf	635	10	that	that	WDT
cord-022313-2675sjlf	635	11	is	be	VBZ
cord-022313-2675sjlf	635	12	necessary	necessary	JJ
cord-022313-2675sjlf	635	13	for	for	IN
cord-022313-2675sjlf	635	14	the	the	DT
cord-022313-2675sjlf	635	15	secretory	secretory	JJ
cord-022313-2675sjlf	635	16	process	process	NN
cord-022313-2675sjlf	635	17	(	(	-LRB-
cord-022313-2675sjlf	635	18	253	253	CD
cord-022313-2675sjlf	635	19	)	)	-RRB-
cord-022313-2675sjlf	635	20	.	.	.
cord-022313-2675sjlf	636	1	A	a	DT
cord-022313-2675sjlf	636	2	recently	recently	RB
cord-022313-2675sjlf	636	3	discovered	discover	VBN
cord-022313-2675sjlf	636	4	and	and	CC
cord-022313-2675sjlf	636	5	vegry	vegry	NNP
cord-022313-2675sjlf	636	6	useful	useful	JJ
cord-022313-2675sjlf	636	7	antibiotic	antibiotic	NN
cord-022313-2675sjlf	636	8	,	,	,
cord-022313-2675sjlf	636	9	called	call	VBN
cord-022313-2675sjlf	636	10	brefeldin	brefeldin	NNP
cord-022313-2675sjlf	636	11	A	A	NNP
cord-022313-2675sjlf	636	12	,	,	,
cord-022313-2675sjlf	636	13	also	also	RB
cord-022313-2675sjlf	636	14	inhibits	inhibit	VBZ
cord-022313-2675sjlf	636	15	the	the	DT
cord-022313-2675sjlf	636	16	secretion	secretion	NN
cord-022313-2675sjlf	636	17	of	of	IN
cord-022313-2675sjlf	636	18	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	636	19	in	in	IN
cord-022313-2675sjlf	636	20	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	636	21	but	but	CC
cord-022313-2675sjlf	636	22	does	do	VBZ
cord-022313-2675sjlf	636	23	not	not	RB
cord-022313-2675sjlf	636	24	affect	affect	VB
cord-022313-2675sjlf	636	25	protein	protein	NN
cord-022313-2675sjlf	636	26	synthesis	synthesis	NN
cord-022313-2675sjlf	636	27	.	.	.
cord-022313-2675sjlf	637	1	Brefeldin	Brefeldin	NNP
cord-022313-2675sjlf	637	2	inhibited	inhibit	VBD
cord-022313-2675sjlf	637	3	the	the	DT
cord-022313-2675sjlf	637	4	terminal	terminal	JJ
cord-022313-2675sjlf	637	5	glycosylation	glycosylation	NN
cord-022313-2675sjlf	637	6	of	of	IN
cord-022313-2675sjlf	637	7	c^-protease	c^-protease	CD
cord-022313-2675sjlf	637	8	inhibitor	inhibitor	NN
cord-022313-2675sjlf	637	9	and	and	CC
cord-022313-2675sjlf	637	10	haptoglobulin	haptoglobulin	NNP
cord-022313-2675sjlf	637	11	,	,	,
cord-022313-2675sjlf	637	12	as	as	RB
cord-022313-2675sjlf	637	13	well	well	RB
cord-022313-2675sjlf	637	14	as	as	IN
cord-022313-2675sjlf	637	15	the	the	DT
cord-022313-2675sjlf	637	16	conversion	conversion	NN
cord-022313-2675sjlf	637	17	of	of	IN
cord-022313-2675sjlf	637	18	proalbumin	proalbumin	NNP
cord-022313-2675sjlf	637	19	to	to	IN
cord-022313-2675sjlf	637	20	albumin	albumin	NN
cord-022313-2675sjlf	637	21	.	.	.
cord-022313-2675sjlf	638	1	Both	both	DT
cord-022313-2675sjlf	638	2	of	of	IN
cord-022313-2675sjlf	638	3	these	these	DT
cord-022313-2675sjlf	638	4	modifications	modification	NNS
cord-022313-2675sjlf	638	5	appear	appear	VBP
cord-022313-2675sjlf	638	6	to	to	TO
cord-022313-2675sjlf	638	7	occur	occur	VB
cord-022313-2675sjlf	638	8	in	in	IN
cord-022313-2675sjlf	638	9	the	the	DT
cord-022313-2675sjlf	638	10	trans	trans	NNP
cord-022313-2675sjlf	638	11	-	-	NNP
cord-022313-2675sjlf	638	12	Golgi	Golgi	NNP
cord-022313-2675sjlf	638	13	(	(	-LRB-
cord-022313-2675sjlf	638	14	254	254	CD
cord-022313-2675sjlf	638	15	)	)	-RRB-
cord-022313-2675sjlf	638	16	.	.	.
cord-022313-2675sjlf	639	1	On	on	IN
cord-022313-2675sjlf	639	2	the	the	DT
cord-022313-2675sjlf	639	3	other	other	JJ
cord-022313-2675sjlf	639	4	hand	hand	NN
cord-022313-2675sjlf	639	5	,	,	,
cord-022313-2675sjlf	639	6	the	the	DT
cord-022313-2675sjlf	639	7	proteolytic	proteolytic	JJ
cord-022313-2675sjlf	639	8	processing	processing	NN
cord-022313-2675sjlf	639	9	of	of	IN
cord-022313-2675sjlf	639	10	haptoglobulin	haptoglobulin	NN
cord-022313-2675sjlf	639	11	occurs	occur	VBZ
cord-022313-2675sjlf	639	12	in	in	IN
cord-022313-2675sjlf	639	13	the	the	DT
cord-022313-2675sjlf	639	14	endoplasmic	endoplasmic	NN
cord-022313-2675sjlf	639	15	reticulum	reticulum	NN
cord-022313-2675sjlf	639	16	and	and	CC
cord-022313-2675sjlf	639	17	this	this	DT
cord-022313-2675sjlf	639	18	modifi	modifi	JJ
cord-022313-2675sjlf	639	19	cation	cation	NN
cord-022313-2675sjlf	639	20	was	be	VBD
cord-022313-2675sjlf	639	21	not	not	RB
cord-022313-2675sjlf	639	22	affected	affect	VBN
cord-022313-2675sjlf	639	23	by	by	IN
cord-022313-2675sjlf	639	24	brefeldin	brefeldin	NNS
cord-022313-2675sjlf	639	25	(	(	-LRB-
cord-022313-2675sjlf	639	26	255	255	CD
cord-022313-2675sjlf	639	27	)	)	-RRB-
cord-022313-2675sjlf	639	28	.	.	.
cord-022313-2675sjlf	640	1	The	the	DT
cord-022313-2675sjlf	640	2	effect	effect	NN
cord-022313-2675sjlf	640	3	of	of	IN
cord-022313-2675sjlf	640	4	brefeldin	brefeldin	NNS
cord-022313-2675sjlf	640	5	on	on	IN
cord-022313-2675sjlf	640	6	the	the	DT
cord-022313-2675sjlf	640	7	Golgi	Golgi	NNP
cord-022313-2675sjlf	640	8	complex	complex	NN
cord-022313-2675sjlf	640	9	and	and	CC
cord-022313-2675sjlf	640	10	endoplasmic	endoplasmic	NN
cord-022313-2675sjlf	640	11	reticululm	reticululm	NN
cord-022313-2675sjlf	640	12	of	of	IN
cord-022313-2675sjlf	640	13	retrovirus	retrovirus	NN
cord-022313-2675sjlf	640	14	-	-	HYPH
cord-022313-2675sjlf	640	15	transformed	transform	VBN
cord-022313-2675sjlf	640	16	murine	murine	JJ
cord-022313-2675sjlf	640	17	erythroleukemia	erythroleukemia	NN
cord-022313-2675sjlf	640	18	(	(	-LRB-
cord-022313-2675sjlf	640	19	MEL	MEL	NNP
cord-022313-2675sjlf	640	20	)	)	-RRB-
cord-022313-2675sjlf	640	21	cells	cell	NNS
cord-022313-2675sjlf	640	22	was	be	VBD
cord-022313-2675sjlf	640	23	studied	study	VBN
cord-022313-2675sjlf	640	24	.	.	.
cord-022313-2675sjlf	641	1	Within	within	IN
cord-022313-2675sjlf	641	2	5	5	CD
cord-022313-2675sjlf	641	3	min	min	NN
cord-022313-2675sjlf	641	4	of	of	IN
cord-022313-2675sjlf	641	5	addition	addition	NN
cord-022313-2675sjlf	641	6	of	of	IN
cord-022313-2675sjlf	641	7	this	this	DT
cord-022313-2675sjlf	641	8	compound	compound	NN
cord-022313-2675sjlf	641	9	,	,	,
cord-022313-2675sjlf	641	10	most	most	RBS
cord-022313-2675sjlf	641	11	stacked	stack	VBN
cord-022313-2675sjlf	641	12	cisternae	cisternae	NNP
cord-022313-2675sjlf	641	13	were	be	VBD
cord-022313-2675sjlf	641	14	converted	convert	VBN
cord-022313-2675sjlf	641	15	to	to	IN
cord-022313-2675sjlf	641	16	vesicles	vesicle	NNS
cord-022313-2675sjlf	641	17	that	that	WDT
cord-022313-2675sjlf	641	18	were	be	VBD
cord-022313-2675sjlf	641	19	scattered	scatter	VBN
cord-022313-2675sjlf	641	20	throughout	throughout	IN
cord-022313-2675sjlf	641	21	the	the	DT
cord-022313-2675sjlf	641	22	centrosphere	centrosphere	JJ
cord-022313-2675sjlf	641	23	region	region	NN
cord-022313-2675sjlf	641	24	,	,	,
cord-022313-2675sjlf	641	25	and	and	CC
cord-022313-2675sjlf	641	26	by	by	IN
cord-022313-2675sjlf	641	27	30	30	CD
cord-022313-2675sjlf	641	28	min	min	NN
cord-022313-2675sjlf	641	29	,	,	,
cord-022313-2675sjlf	641	30	the	the	DT
cord-022313-2675sjlf	641	31	Golgi	Golgi	NNP
cord-022313-2675sjlf	641	32	complexes	complex	NNS
cord-022313-2675sjlf	641	33	were	be	VBD
cord-022313-2675sjlf	641	34	completely	completely	RB
cord-022313-2675sjlf	641	35	disassembled	disassemble	VBN
cord-022313-2675sjlf	641	36	.	.	.
cord-022313-2675sjlf	642	1	Over	over	IN
cord-022313-2675sjlf	642	2	the	the	DT
cord-022313-2675sjlf	642	3	next	next	JJ
cord-022313-2675sjlf	642	4	few	few	JJ
cord-022313-2675sjlf	642	5	hours	hour	NNS
cord-022313-2675sjlf	642	6	,	,	,
cord-022313-2675sjlf	642	7	the	the	DT
cord-022313-2675sjlf	642	8	number	number	NN
cord-022313-2675sjlf	642	9	of	of	IN
cord-022313-2675sjlf	642	10	vesi	vesi	NNP
cord-022313-2675sjlf	642	11	cles	cles	NNP
cord-022313-2675sjlf	642	12	in	in	IN
cord-022313-2675sjlf	642	13	the	the	DT
cord-022313-2675sjlf	642	14	Golgi	Golgi	NNP
cord-022313-2675sjlf	642	15	area	area	NN
cord-022313-2675sjlf	642	16	decreased	decrease	VBD
cord-022313-2675sjlf	642	17	concomitantly	concomitantly	RB
cord-022313-2675sjlf	642	18	with	with	IN
cord-022313-2675sjlf	642	19	an	an	DT
cord-022313-2675sjlf	642	20	expansion	expansion	NN
cord-022313-2675sjlf	642	21	of	of	IN
cord-022313-2675sjlf	642	22	a	a	DT
cord-022313-2675sjlf	642	23	predominantly	predominantly	RB
cord-022313-2675sjlf	642	24	smooth	smooth	JJ
cord-022313-2675sjlf	642	25	endoplasmic	endoplasmic	NN
cord-022313-2675sjlf	642	26	reticulum	reticulum	NN
cord-022313-2675sjlf	642	27	that	that	WDT
cord-022313-2675sjlf	642	28	consisted	consist	VBD
cord-022313-2675sjlf	642	29	of	of	IN
cord-022313-2675sjlf	642	30	a	a	DT
cord-022313-2675sjlf	642	31	net	net	JJ
cord-022313-2675sjlf	642	32	work	work	NN
cord-022313-2675sjlf	642	33	of	of	IN
cord-022313-2675sjlf	642	34	dilated	dilated	JJ
cord-022313-2675sjlf	642	35	tubules	tubule	NNS
cord-022313-2675sjlf	642	36	in	in	IN
cord-022313-2675sjlf	642	37	continuity	continuity	NN
cord-022313-2675sjlf	642	38	with	with	IN
cord-022313-2675sjlf	642	39	regular	regular	JJ
cord-022313-2675sjlf	642	40	RER	RER	NNP
cord-022313-2675sjlf	642	41	cisternae	cisternae	NNP
cord-022313-2675sjlf	642	42	,	,	,
cord-022313-2675sjlf	642	43	annulate	annulate	NNP
cord-022313-2675sjlf	642	44	lamellae	lamella	NNS
cord-022313-2675sjlf	642	45	,	,	,
cord-022313-2675sjlf	642	46	and	and	CC
cord-022313-2675sjlf	642	47	the	the	DT
cord-022313-2675sjlf	642	48	nuclear	nuclear	JJ
cord-022313-2675sjlf	642	49	envelope	envelope	NN
cord-022313-2675sjlf	642	50	.	.	.
cord-022313-2675sjlf	643	1	By	by	IN
cord-022313-2675sjlf	643	2	electron	electron	NN
cord-022313-2675sjlf	643	3	microscopy	microscopy	NNS
cord-022313-2675sjlf	643	4	,	,	,
cord-022313-2675sjlf	643	5	viral	viral	JJ
cord-022313-2675sjlf	643	6	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	643	7	appeared	appear	VBD
cord-022313-2675sjlf	643	8	to	to	TO
cord-022313-2675sjlf	643	9	accumulate	accumulate	VB
cord-022313-2675sjlf	643	10	on	on	IN
cord-022313-2675sjlf	643	11	these	these	DT
cord-022313-2675sjlf	643	12	membranes	membrane	NNS
cord-022313-2675sjlf	643	13	and	and	CC
cord-022313-2675sjlf	643	14	immature	immature	JJ
cord-022313-2675sjlf	643	15	virions	virion	NNS
cord-022313-2675sjlf	643	16	budded	bud	VBN
cord-022313-2675sjlf	643	17	preferentially	preferentially	RB
cord-022313-2675sjlf	643	18	into	into	IN
cord-022313-2675sjlf	643	19	the	the	DT
cord-022313-2675sjlf	643	20	cisternal	cisternal	JJ
cord-022313-2675sjlf	643	21	space	space	NN
cord-022313-2675sjlf	643	22	.	.	.
cord-022313-2675sjlf	644	1	These	these	DT
cord-022313-2675sjlf	644	2	findings	finding	NNS
cord-022313-2675sjlf	644	3	suggest	suggest	VBP
cord-022313-2675sjlf	644	4	that	that	IN
cord-022313-2675sjlf	644	5	brefeldin	brefeldin	NNP
cord-022313-2675sjlf	644	6	blocks	block	VBZ
cord-022313-2675sjlf	644	7	the	the	DT
cord-022313-2675sjlf	644	8	intracellular	intracellular	JJ
cord-022313-2675sjlf	644	9	transport	transport	NN
cord-022313-2675sjlf	644	10	of	of	IN
cord-022313-2675sjlf	644	11	newly	newly	RB
cord-022313-2675sjlf	644	12	synthesized	synthesize	VBN
cord-022313-2675sjlf	644	13	cellular	cellular	JJ
cord-022313-2675sjlf	644	14	and	and	CC
cord-022313-2675sjlf	644	15	viral	viral	JJ
cord-022313-2675sjlf	644	16	proteins	protein	NNS
cord-022313-2675sjlf	644	17	immediately	immediately	RB
cord-022313-2675sjlf	644	18	distal	distal	JJ
cord-022313-2675sjlf	644	19	to	to	IN
cord-022313-2675sjlf	644	20	the	the	DT
cord-022313-2675sjlf	644	21	distinct	distinct	JJ
cord-022313-2675sjlf	644	22	compartment	compartment	NN
cord-022313-2675sjlf	644	23	of	of	IN
cord-022313-2675sjlf	644	24	the	the	DT
cord-022313-2675sjlf	644	25	ER	ER	NNP
cord-022313-2675sjlf	644	26	.	.	.
cord-022313-2675sjlf	645	1	The	the	DT
cord-022313-2675sjlf	645	2	effects	effect	NNS
cord-022313-2675sjlf	645	3	of	of	IN
cord-022313-2675sjlf	645	4	brefeldin	brefeldin	NNS
cord-022313-2675sjlf	645	5	were	be	VBD
cord-022313-2675sjlf	645	6	completely	completely	RB
cord-022313-2675sjlf	645	7	reversible	reversible	JJ
cord-022313-2675sjlf	645	8	and	and	CC
cord-022313-2675sjlf	645	9	,	,	,
cord-022313-2675sjlf	645	10	within	within	IN
cord-022313-2675sjlf	645	11	a	a	DT
cord-022313-2675sjlf	645	12	short	short	JJ
cord-022313-2675sjlf	645	13	time	time	NN
cord-022313-2675sjlf	645	14	after	after	IN
cord-022313-2675sjlf	645	15	removal	removal	NN
cord-022313-2675sjlf	645	16	of	of	IN
cord-022313-2675sjlf	645	17	the	the	DT
cord-022313-2675sjlf	645	18	drug	drug	NN
cord-022313-2675sjlf	645	19	,	,	,
cord-022313-2675sjlf	645	20	Golgi	Golgi	NNP
cord-022313-2675sjlf	645	21	cisternae	cisternae	NNP
cord-022313-2675sjlf	645	22	bergan	bergan	NN
cord-022313-2675sjlf	645	23	to	to	TO
cord-022313-2675sjlf	645	24	reappear	reappear	VB
cord-022313-2675sjlf	645	25	(	(	-LRB-
cord-022313-2675sjlf	645	26	256	256	CD
cord-022313-2675sjlf	645	27	)	)	-RRB-
cord-022313-2675sjlf	645	28	.	.	.
cord-022313-2675sjlf	646	1	In	in	IN
cord-022313-2675sjlf	646	2	a	a	DT
cord-022313-2675sjlf	646	3	cell	cell	NN
cord-022313-2675sjlf	646	4	free	free	JJ
cord-022313-2675sjlf	646	5	system	system	NN
cord-022313-2675sjlf	646	6	,	,	,
cord-022313-2675sjlf	646	7	brefeldin	brefeldin	NNP
cord-022313-2675sjlf	646	8	A	A	NNP
cord-022313-2675sjlf	646	9	prevented	prevent	VBD
cord-022313-2675sjlf	646	10	the	the	DT
cord-022313-2675sjlf	646	11	assembly	assembly	NN
cord-022313-2675sjlf	646	12	of	of	IN
cord-022313-2675sjlf	646	13	nonclathrin	nonclathrin	JJ
cord-022313-2675sjlf	646	14	-	-	HYPH
cord-022313-2675sjlf	646	15	coated	coat	VBN
cord-022313-2675sjlf	646	16	vesicles	vesicle	NNS
cord-022313-2675sjlf	646	17	from	from	IN
cord-022313-2675sjlf	646	18	Golgi	Golgi	NNP
cord-022313-2675sjlf	646	19	cisternae	cisternae	NNP
cord-022313-2675sjlf	646	20	.	.	.
cord-022313-2675sjlf	647	1	Furthermore	furthermore	RB
cord-022313-2675sjlf	647	2	,	,	,
cord-022313-2675sjlf	647	3	when	when	WRB
cord-022313-2675sjlf	647	4	coated	coated	JJ
cord-022313-2675sjlf	647	5	vesicle	vesicle	NN
cord-022313-2675sjlf	647	6	assembly	assembly	NN
cord-022313-2675sjlf	647	7	is	be	VBZ
cord-022313-2675sjlf	647	8	blocked	block	VBN
cord-022313-2675sjlf	647	9	,	,	,
cord-022313-2675sjlf	647	10	extensive	extensive	JJ
cord-022313-2675sjlf	647	11	tubule	tubule	NN
cord-022313-2675sjlf	647	12	networks	network	NNS
cord-022313-2675sjlf	647	13	form	form	VBP
cord-022313-2675sjlf	647	14	.	.	.
cord-022313-2675sjlf	648	1	These	these	DT
cord-022313-2675sjlf	648	2	connect	connect	VBP
cord-022313-2675sjlf	648	3	previously	previously	RB
cord-022313-2675sjlf	648	4	separate	separate	JJ
cord-022313-2675sjlf	648	5	cisternae	cisternae	NN
cord-022313-2675sjlf	648	6	and	and	CC
cord-022313-2675sjlf	648	7	stacks	stack	VBZ
cord-022313-2675sjlf	648	8	into	into	IN
cord-022313-2675sjlf	648	9	a	a	DT
cord-022313-2675sjlf	648	10	single	single	JJ
cord-022313-2675sjlf	648	11	topological	topological	JJ
cord-022313-2675sjlf	648	12	unit	unit	NN
cord-022313-2675sjlf	648	13	that	that	WDT
cord-022313-2675sjlf	648	14	allows	allow	VBZ
cord-022313-2675sjlf	648	15	the	the	DT
cord-022313-2675sjlf	648	16	mixing	mixing	NN
cord-022313-2675sjlf	648	17	of	of	IN
cord-022313-2675sjlf	648	18	the	the	DT
cord-022313-2675sjlf	648	19	contents	content	NNS
cord-022313-2675sjlf	648	20	of	of	IN
cord-022313-2675sjlf	648	21	Golgi	Golgi	NNP
cord-022313-2675sjlf	648	22	cisternae	cisternae	NNP
cord-022313-2675sjlf	648	23	(	(	-LRB-
cord-022313-2675sjlf	648	24	257	257	CD
cord-022313-2675sjlf	648	25	)	)	-RRB-
cord-022313-2675sjlf	648	26	.	.	.
cord-022313-2675sjlf	649	1	These	these	DT
cord-022313-2675sjlf	649	2	studies	study	NNS
cord-022313-2675sjlf	649	3	are	be	VBP
cord-022313-2675sjlf	649	4	consistent	consistent	JJ
cord-022313-2675sjlf	649	5	with	with	IN
cord-022313-2675sjlf	649	6	in	in	IN
cord-022313-2675sjlf	649	7	vivo	vivo	NN
cord-022313-2675sjlf	649	8	studies	study	NNS
cord-022313-2675sjlf	649	9	that	that	WDT
cord-022313-2675sjlf	649	10	showed	show	VBD
cord-022313-2675sjlf	649	11	that	that	IN
cord-022313-2675sjlf	649	12	the	the	DT
cord-022313-2675sjlf	649	13	earliest	early	RBS
cord-022313-2675sjlf	649	14	detectable	detectable	JJ
cord-022313-2675sjlf	649	15	effect	effect	NN
cord-022313-2675sjlf	649	16	of	of	IN
cord-022313-2675sjlf	649	17	brefeldin	brefeldin	NNS
cord-022313-2675sjlf	649	18	was	be	VBD
cord-022313-2675sjlf	649	19	the	the	DT
cord-022313-2675sjlf	649	20	displacement	displacement	NN
cord-022313-2675sjlf	649	21	from	from	IN
cord-022313-2675sjlf	649	22	the	the	DT
cord-022313-2675sjlf	649	23	Golgi	Golgi	NNP
cord-022313-2675sjlf	649	24	stacks	stack	NNS
cord-022313-2675sjlf	649	25	of	of	IN
cord-022313-2675sjlf	649	26	a	a	DT
cord-022313-2675sjlf	649	27	110-kDa	110-kda	CD
cord-022313-2675sjlf	649	28	protein	protein	NN
cord-022313-2675sjlf	649	29	(	(	-LRB-
cord-022313-2675sjlf	649	30	258	258	CD
cord-022313-2675sjlf	649	31	,	,	,
cord-022313-2675sjlf	649	32	259	259	CD
cord-022313-2675sjlf	649	33	)	)	-RRB-
cord-022313-2675sjlf	649	34	,	,	,
cord-022313-2675sjlf	649	35	and	and	CC
cord-022313-2675sjlf	649	36	this	this	DT
cord-022313-2675sjlf	649	37	protein	protein	NN
cord-022313-2675sjlf	649	38	was	be	VBD
cord-022313-2675sjlf	649	39	found	find	VBN
cord-022313-2675sjlf	649	40	to	to	TO
cord-022313-2675sjlf	649	41	be	be	VB
cord-022313-2675sjlf	649	42	identical	identical	JJ
cord-022313-2675sjlf	649	43	to	to	IN
cord-022313-2675sjlf	649	44	one	one	CD
cord-022313-2675sjlf	649	45	of	of	IN
cord-022313-2675sjlf	649	46	the	the	DT
cord-022313-2675sjlf	649	47	major	major	JJ
cord-022313-2675sjlf	649	48	coat	coat	NN
cord-022313-2675sjlf	649	49	protein	protein	NN
cord-022313-2675sjlf	649	50	subunits	subunit	NNS
cord-022313-2675sjlf	649	51	(	(	-LRB-
cord-022313-2675sjlf	649	52	COPS	cop	NNS
cord-022313-2675sjlf	649	53	)	)	-RRB-
cord-022313-2675sjlf	649	54	of	of	IN
cord-022313-2675sjlf	649	55	Golgi	Golgi	NNP
cord-022313-2675sjlf	649	56	non	non	JJ
cord-022313-2675sjlf	649	57	-	-	JJ
cord-022313-2675sjlf	649	58	clathrin	clathrin	JJ
cord-022313-2675sjlf	649	59	-	-	HYPH
cord-022313-2675sjlf	649	60	coated	coat	VBN
cord-022313-2675sjlf	649	61	vesicles	vesicle	NNS
cord-022313-2675sjlf	649	62	,	,	,
cord-022313-2675sjlf	649	63	β	β	NN
cord-022313-2675sjlf	649	64	-	-	HYPH
cord-022313-2675sjlf	649	65	COP	cop	NN
cord-022313-2675sjlf	649	66	(	(	-LRB-
cord-022313-2675sjlf	649	67	260	260	CD
cord-022313-2675sjlf	649	68	)	)	-RRB-
cord-022313-2675sjlf	649	69	.	.	.
cord-022313-2675sjlf	650	1	Thus	thus	RB
cord-022313-2675sjlf	650	2	,	,	,
cord-022313-2675sjlf	650	3	a	a	DT
cord-022313-2675sjlf	650	4	simple	simple	JJ
cord-022313-2675sjlf	650	5	explanation	explanation	NN
cord-022313-2675sjlf	650	6	for	for	IN
cord-022313-2675sjlf	650	7	the	the	DT
cord-022313-2675sjlf	650	8	effect	effect	NN
cord-022313-2675sjlf	650	9	of	of	IN
cord-022313-2675sjlf	650	10	this	this	DT
cord-022313-2675sjlf	650	11	interesting	interesting	JJ
cord-022313-2675sjlf	650	12	and	and	CC
cord-022313-2675sjlf	650	13	very	very	RB
cord-022313-2675sjlf	650	14	useful	useful	JJ
cord-022313-2675sjlf	650	15	compound	compound	NN
cord-022313-2675sjlf	650	16	is	be	VBZ
cord-022313-2675sjlf	650	17	that	that	IN
cord-022313-2675sjlf	650	18	it	-PRON-	PRP
cord-022313-2675sjlf	650	19	acts	act	VBZ
cord-022313-2675sjlf	650	20	by	by	IN
cord-022313-2675sjlf	650	21	blocking	block	VBG
cord-022313-2675sjlf	650	22	the	the	DT
cord-022313-2675sjlf	650	23	budding	budding	NN
cord-022313-2675sjlf	650	24	of	of	IN
cord-022313-2675sjlf	650	25	coated	coated	JJ
cord-022313-2675sjlf	650	26	transport	transport	NN
cord-022313-2675sjlf	650	27	vesicles	vesicle	NNS
cord-022313-2675sjlf	650	28	.	.	.
cord-022313-2675sjlf	651	1	Brefeldin	Brefeldin	NNP
cord-022313-2675sjlf	651	2	A	A	NNP
cord-022313-2675sjlf	651	3	is	be	VBZ
cord-022313-2675sjlf	651	4	now	now	RB
cord-022313-2675sjlf	651	5	being	be	VBG
cord-022313-2675sjlf	651	6	widely	widely	RB
cord-022313-2675sjlf	651	7	used	use	VBN
cord-022313-2675sjlf	651	8	in	in	IN
cord-022313-2675sjlf	651	9	cell	cell	NN
cord-022313-2675sjlf	651	10	biology	biology	NN
cord-022313-2675sjlf	651	11	and	and	CC
cord-022313-2675sjlf	651	12	biochemistry	biochemistry	NN
cord-022313-2675sjlf	651	13	and	and	CC
cord-022313-2675sjlf	651	14	its	-PRON-	PRP$
cord-022313-2675sjlf	651	15	use	use	NN
cord-022313-2675sjlf	651	16	will	will	MD
cord-022313-2675sjlf	651	17	undoubtedly	undoubtedly	RB
cord-022313-2675sjlf	651	18	provide	provide	VB
cord-022313-2675sjlf	651	19	important	important	JJ
cord-022313-2675sjlf	651	20	insight	insight	NN
cord-022313-2675sjlf	651	21	into	into	IN
cord-022313-2675sjlf	651	22	mechanisms	mechanism	NNS
cord-022313-2675sjlf	651	23	of	of	IN
cord-022313-2675sjlf	651	24	protein	protein	NN
cord-022313-2675sjlf	651	25	transport	transport	NN
cord-022313-2675sjlf	651	26	and	and	CC
cord-022313-2675sjlf	651	27	Golgi	Golgi	NNP
cord-022313-2675sjlf	651	28	assembly	assembly	NN
cord-022313-2675sjlf	651	29	and	and	CC
cord-022313-2675sjlf	651	30	disas	disas	NNP
cord-022313-2675sjlf	651	31	sembly	sembly	NNP
cord-022313-2675sjlf	651	32	.	.	.
cord-022313-2675sjlf	652	1	As	as	IN
cord-022313-2675sjlf	652	2	indicated	indicate	VBN
cord-022313-2675sjlf	652	3	earlier	early	RBR
cord-022313-2675sjlf	652	4	,	,	,
cord-022313-2675sjlf	652	5	many	many	JJ
cord-022313-2675sjlf	652	6	membrane	membrane	NN
cord-022313-2675sjlf	652	7	proteins	protein	NNS
cord-022313-2675sjlf	652	8	are	be	VBP
cord-022313-2675sjlf	652	9	anchored	anchor	VBN
cord-022313-2675sjlf	652	10	to	to	IN
cord-022313-2675sjlf	652	11	the	the	DT
cord-022313-2675sjlf	652	12	cell	cell	NN
cord-022313-2675sjlf	652	13	surface	surface	NN
cord-022313-2675sjlf	652	14	by	by	IN
cord-022313-2675sjlf	652	15	a	a	DT
cord-022313-2675sjlf	652	16	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NN
cord-022313-2675sjlf	652	17	(	(	-LRB-
cord-022313-2675sjlf	652	18	GPI	GPI	NNP
cord-022313-2675sjlf	652	19	)	)	-RRB-
cord-022313-2675sjlf	652	20	anchor	anchor	NN
cord-022313-2675sjlf	652	21	in	in	IN
cord-022313-2675sjlf	652	22	which	which	WDT
cord-022313-2675sjlf	652	23	the	the	DT
cord-022313-2675sjlf	652	24	protein	protein	NN
cord-022313-2675sjlf	652	25	is	be	VBZ
cord-022313-2675sjlf	652	26	linked	link	VBN
cord-022313-2675sjlf	652	27	from	from	IN
cord-022313-2675sjlf	652	28	its	-PRON-	PRP$
cord-022313-2675sjlf	652	29	carboxyl	carboxyl	NN
cord-022313-2675sjlf	652	30	-	-	HYPH
cord-022313-2675sjlf	652	31	terminal	terminal	NN
cord-022313-2675sjlf	652	32	region	region	NN
cord-022313-2675sjlf	652	33	to	to	IN
cord-022313-2675sjlf	652	34	the	the	DT
cord-022313-2675sjlf	652	35	glycan	glycan	NN
cord-022313-2675sjlf	652	36	via	via	IN
cord-022313-2675sjlf	652	37	a	a	DT
cord-022313-2675sjlf	652	38	phosphoethanolamine	phosphoethanolamine	JJ
cord-022313-2675sjlf	652	39	bridge	bridge	NN
cord-022313-2675sjlf	652	40	.	.	.
cord-022313-2675sjlf	653	1	Since	since	IN
cord-022313-2675sjlf	653	2	the	the	DT
cord-022313-2675sjlf	653	3	glycan	glycan	NN
cord-022313-2675sjlf	653	4	portion	portion	NN
cord-022313-2675sjlf	653	5	of	of	IN
cord-022313-2675sjlf	653	6	the	the	DT
cord-022313-2675sjlf	653	7	molecule	molecule	NN
cord-022313-2675sjlf	653	8	is	be	VBZ
cord-022313-2675sjlf	653	9	essential	essential	JJ
cord-022313-2675sjlf	653	10	to	to	IN
cord-022313-2675sjlf	653	11	this	this	DT
cord-022313-2675sjlf	653	12	anchoring	anchor	VBG
cord-022313-2675sjlf	653	13	mechanism	mechanism	NN
cord-022313-2675sjlf	653	14	,	,	,
cord-022313-2675sjlf	653	15	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	653	16	of	of	IN
cord-022313-2675sjlf	653	17	glycan	glycan	NN
cord-022313-2675sjlf	653	18	formation	formation	NN
cord-022313-2675sjlf	653	19	should	should	MD
cord-022313-2675sjlf	653	20	be	be	VB
cord-022313-2675sjlf	653	21	of	of	IN
cord-022313-2675sjlf	653	22	considerable	considerable	JJ
cord-022313-2675sjlf	653	23	interest	interest	NN
cord-022313-2675sjlf	653	24	for	for	IN
cord-022313-2675sjlf	653	25	determining	determine	VBG
cord-022313-2675sjlf	653	26	the	the	DT
cord-022313-2675sjlf	653	27	role	role	NN
cord-022313-2675sjlf	653	28	of	of	IN
cord-022313-2675sjlf	653	29	this	this	DT
cord-022313-2675sjlf	653	30	anchoring	anchor	VBG
cord-022313-2675sjlf	653	31	mechanism	mechanism	NN
cord-022313-2675sjlf	653	32	,	,	,
cord-022313-2675sjlf	653	33	as	as	RB
cord-022313-2675sjlf	653	34	well	well	RB
cord-022313-2675sjlf	653	35	as	as	IN
cord-022313-2675sjlf	653	36	for	for	IN
cord-022313-2675sjlf	653	37	understanding	understand	VBG
cord-022313-2675sjlf	653	38	the	the	DT
cord-022313-2675sjlf	653	39	function	function	NN
cord-022313-2675sjlf	653	40	of	of	IN
cord-022313-2675sjlf	653	41	the	the	DT
cord-022313-2675sjlf	653	42	anchored	anchor	VBN
cord-022313-2675sjlf	653	43	proteins	protein	NNS
cord-022313-2675sjlf	653	44	.	.	.
cord-022313-2675sjlf	654	1	As	as	IN
cord-022313-2675sjlf	654	2	discussed	discuss	VBN
cord-022313-2675sjlf	654	3	in	in	IN
cord-022313-2675sjlf	654	4	a	a	DT
cord-022313-2675sjlf	654	5	previous	previous	JJ
cord-022313-2675sjlf	654	6	section	section	NN
cord-022313-2675sjlf	654	7	,	,	,
cord-022313-2675sjlf	654	8	the	the	DT
cord-022313-2675sjlf	654	9	manno	manno	NNP
cord-022313-2675sjlf	654	10	syl	syl	NNP
cord-022313-2675sjlf	654	11	residues	residue	NNS
cord-022313-2675sjlf	654	12	of	of	IN
cord-022313-2675sjlf	654	13	the	the	DT
cord-022313-2675sjlf	654	14	anchor	anchor	NN
cord-022313-2675sjlf	654	15	are	be	VBP
cord-022313-2675sjlf	654	16	donated	donate	VBN
cord-022313-2675sjlf	654	17	via	via	IN
cord-022313-2675sjlf	654	18	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	654	19	-	-	HYPH
cord-022313-2675sjlf	654	20	P	p	NN
cord-022313-2675sjlf	654	21	-	-	HYPH
cord-022313-2675sjlf	654	22	mannose	mannose	NN
cord-022313-2675sjlf	654	23	,	,	,
cord-022313-2675sjlf	654	24	so	so	IN
cord-022313-2675sjlf	654	25	inhibi	inhibi	NNP
cord-022313-2675sjlf	654	26	tors	tor	NNS
cord-022313-2675sjlf	654	27	that	that	WDT
cord-022313-2675sjlf	654	28	block	block	VBP
cord-022313-2675sjlf	654	29	the	the	DT
cord-022313-2675sjlf	654	30	formation	formation	NN
cord-022313-2675sjlf	654	31	of	of	IN
cord-022313-2675sjlf	654	32	this	this	DT
cord-022313-2675sjlf	654	33	glycolipid	glycolipid	NN
cord-022313-2675sjlf	654	34	should	should	MD
cord-022313-2675sjlf	654	35	affect	affect	VB
cord-022313-2675sjlf	654	36	anchor	anchor	NN
cord-022313-2675sjlf	654	37	formation	formation	NN
cord-022313-2675sjlf	654	38	.	.	.
cord-022313-2675sjlf	655	1	Thus	thus	RB
cord-022313-2675sjlf	655	2	,	,	,
cord-022313-2675sjlf	655	3	amphomycin	amphomycin	NNS
cord-022313-2675sjlf	655	4	was	be	VBD
cord-022313-2675sjlf	655	5	effective	effective	JJ
cord-022313-2675sjlf	655	6	in	in	IN
cord-022313-2675sjlf	655	7	cell	cell	NN
cord-022313-2675sjlf	655	8	-	-	HYPH
cord-022313-2675sjlf	655	9	free	free	JJ
cord-022313-2675sjlf	655	10	experiments	experiment	NNS
cord-022313-2675sjlf	655	11	to	to	TO
cord-022313-2675sjlf	655	12	demonstrate	demonstrate	VB
cord-022313-2675sjlf	655	13	that	that	IN
cord-022313-2675sjlf	655	14	the	the	DT
cord-022313-2675sjlf	655	15	mannosyl	mannosyl	NNP
cord-022313-2675sjlf	655	16	donor	donor	NN
cord-022313-2675sjlf	655	17	for	for	IN
cord-022313-2675sjlf	655	18	the	the	DT
cord-022313-2675sjlf	655	19	three	three	CD
cord-022313-2675sjlf	655	20	mannose	mannose	JJ
cord-022313-2675sjlf	655	21	units	unit	NNS
cord-022313-2675sjlf	655	22	of	of	IN
cord-022313-2675sjlf	655	23	the	the	DT
cord-022313-2675sjlf	655	24	glycan	glycan	NN
cord-022313-2675sjlf	655	25	portion	portion	NN
cord-022313-2675sjlf	655	26	of	of	IN
cord-022313-2675sjlf	655	27	the	the	DT
cord-022313-2675sjlf	655	28	anchor	anchor	NN
cord-022313-2675sjlf	655	29	was	be	VBD
cord-022313-2675sjlf	655	30	indeed	indeed	RB
cord-022313-2675sjlf	655	31	dolichyl	dolichyl	JJ
cord-022313-2675sjlf	655	32	-	-	HYPH
cord-022313-2675sjlf	655	33	P	p	NN
cord-022313-2675sjlf	655	34	-	-	HYPH
cord-022313-2675sjlf	655	35	mannose	mannose	NN
cord-022313-2675sjlf	655	36	(	(	-LRB-
cord-022313-2675sjlf	655	37	261	261	CD
cord-022313-2675sjlf	655	38	)	)	-RRB-
cord-022313-2675sjlf	655	39	.	.	.
cord-022313-2675sjlf	656	1	The	the	DT
cord-022313-2675sjlf	656	2	sugar	sugar	NN
cord-022313-2675sjlf	656	3	analog	analog	NN
cord-022313-2675sjlf	656	4	,	,	,
cord-022313-2675sjlf	656	5	2-fluoro-2-deoxyglucose	2-fluoro-2-deoxyglucose	CD
cord-022313-2675sjlf	656	6	,	,	,
cord-022313-2675sjlf	656	7	which	which	WDT
cord-022313-2675sjlf	656	8	was	be	VBD
cord-022313-2675sjlf	656	9	previously	previously	RB
cord-022313-2675sjlf	656	10	shown	show	VBN
cord-022313-2675sjlf	656	11	to	to	TO
cord-022313-2675sjlf	656	12	inhibit	inhibit	VB
cord-022313-2675sjlf	656	13	dolichyl	dolichyl	NN
cord-022313-2675sjlf	656	14	-	-	HYPH
cord-022313-2675sjlf	656	15	P	p	NN
cord-022313-2675sjlf	656	16	-	-	HYPH
cord-022313-2675sjlf	656	17	mannose	mannose	NN
cord-022313-2675sjlf	656	18	formation	formation	NN
cord-022313-2675sjlf	656	19	and	and	CC
cord-022313-2675sjlf	656	20	lipid	lipid	NN
cord-022313-2675sjlf	656	21	-	-	HYPH
cord-022313-2675sjlf	656	22	linked	link	VBN
cord-022313-2675sjlf	656	23	oligosaccha	oligosaccha	NN
cord-022313-2675sjlf	656	24	rides	ride	NNS
cord-022313-2675sjlf	656	25	(	(	-LRB-
cord-022313-2675sjlf	656	26	154	154	CD
cord-022313-2675sjlf	656	27	)	)	-RRB-
cord-022313-2675sjlf	656	28	,	,	,
cord-022313-2675sjlf	656	29	also	also	RB
cord-022313-2675sjlf	656	30	altered	alter	VBD
cord-022313-2675sjlf	656	31	the	the	DT
cord-022313-2675sjlf	656	32	synthesis	synthesis	NN
cord-022313-2675sjlf	656	33	of	of	IN
cord-022313-2675sjlf	656	34	the	the	DT
cord-022313-2675sjlf	656	35	GPI	GPI	NNP
cord-022313-2675sjlf	656	36	-	-	HYPH
cord-022313-2675sjlf	656	37	anchored	anchor	VBN
cord-022313-2675sjlf	656	38	protein	protein	NN
cord-022313-2675sjlf	656	39	alka	alka	NNP
cord-022313-2675sjlf	656	40	line	line	NN
cord-022313-2675sjlf	656	41	phosphatase	phosphatase	NN
cord-022313-2675sjlf	656	42	in	in	IN
cord-022313-2675sjlf	656	43	JEG-3	JEG-3	NNP
cord-022313-2675sjlf	656	44	cells	cell	NNS
cord-022313-2675sjlf	656	45	and	and	CC
cord-022313-2675sjlf	656	46	caused	cause	VBD
cord-022313-2675sjlf	656	47	the	the	DT
cord-022313-2675sjlf	656	48	accumulation	accumulation	NN
cord-022313-2675sjlf	656	49	of	of	IN
cord-022313-2675sjlf	656	50	a	a	DT
cord-022313-2675sjlf	656	51	proform	proform	NN
cord-022313-2675sjlf	656	52	of	of	IN
cord-022313-2675sjlf	656	53	the	the	DT
cord-022313-2675sjlf	656	54	enzyme	enzyme	NN
cord-022313-2675sjlf	656	55	.	.	.
cord-022313-2675sjlf	657	1	This	this	DT
cord-022313-2675sjlf	657	2	proform	proform	NN
cord-022313-2675sjlf	657	3	was	be	VBD
cord-022313-2675sjlf	657	4	gradually	gradually	RB
cord-022313-2675sjlf	657	5	processed	process	VBN
cord-022313-2675sjlf	657	6	into	into	IN
cord-022313-2675sjlf	657	7	a	a	DT
cord-022313-2675sjlf	657	8	secretory	secretory	JJ
cord-022313-2675sjlf	657	9	form	form	NN
cord-022313-2675sjlf	657	10	by	by	IN
cord-022313-2675sjlf	657	11	proteolytic	proteolytic	JJ
cord-022313-2675sjlf	657	12	removal	removal	NN
cord-022313-2675sjlf	657	13	of	of	IN
cord-022313-2675sjlf	657	14	the	the	DT
cord-022313-2675sjlf	657	15	carboxy	carboxy	JJ
cord-022313-2675sjlf	657	16	-	-	HYPH
cord-022313-2675sjlf	657	17	terminal	terminal	NN
cord-022313-2675sjlf	657	18	hy	hy	NNP
cord-022313-2675sjlf	657	19	drophobic	drophobic	NNP
cord-022313-2675sjlf	657	20	peptide	peptide	NNP
cord-022313-2675sjlf	657	21	(	(	-LRB-
cord-022313-2675sjlf	657	22	262	262	CD
cord-022313-2675sjlf	657	23	)	)	-RRB-
cord-022313-2675sjlf	657	24	.	.	.
cord-022313-2675sjlf	658	1	Thus	thus	RB
cord-022313-2675sjlf	658	2	,	,	,
cord-022313-2675sjlf	658	3	both	both	DT
cord-022313-2675sjlf	658	4	of	of	IN
cord-022313-2675sjlf	658	5	these	these	DT
cord-022313-2675sjlf	658	6	studies	study	NNS
cord-022313-2675sjlf	658	7	indicated	indicate	VBD
cord-022313-2675sjlf	658	8	that	that	IN
cord-022313-2675sjlf	658	9	inhibition	inhibition	NN
cord-022313-2675sjlf	658	10	of	of	IN
cord-022313-2675sjlf	658	11	the	the	DT
cord-022313-2675sjlf	658	12	synthesis	synthesis	NN
cord-022313-2675sjlf	658	13	of	of	IN
cord-022313-2675sjlf	658	14	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	658	15	-	-	HYPH
cord-022313-2675sjlf	658	16	P	p	NN
cord-022313-2675sjlf	658	17	-	-	HYPH
cord-022313-2675sjlf	658	18	mannose	mannose	NN
cord-022313-2675sjlf	658	19	can	can	MD
cord-022313-2675sjlf	658	20	block	block	VB
cord-022313-2675sjlf	658	21	proteinanchor	proteinanchor	NNP
cord-022313-2675sjlf	658	22	assembly	assembly	NNP
cord-022313-2675sjlf	658	23	.	.	.
cord-022313-2675sjlf	659	1	Another	another	DT
cord-022313-2675sjlf	659	2	recently	recently	RB
cord-022313-2675sjlf	659	3	reported	report	VBN
cord-022313-2675sjlf	659	4	inhibitor	inhibitor	NN
cord-022313-2675sjlf	659	5	of	of	IN
cord-022313-2675sjlf	659	6	protein	protein	NN
cord-022313-2675sjlf	659	7	-	-	HYPH
cord-022313-2675sjlf	659	8	anchor	anchor	NN
cord-022313-2675sjlf	659	9	formation	formation	NN
cord-022313-2675sjlf	659	10	is	be	VBZ
cord-022313-2675sjlf	659	11	mannosamine	mannosamine	NN
cord-022313-2675sjlf	659	12	.	.	.
cord-022313-2675sjlf	660	1	Mannosamine	Mannosamine	NNP
cord-022313-2675sjlf	660	2	was	be	VBD
cord-022313-2675sjlf	660	3	previously	previously	RB
cord-022313-2675sjlf	660	4	shown	show	VBN
cord-022313-2675sjlf	660	5	to	to	TO
cord-022313-2675sjlf	660	6	be	be	VB
cord-022313-2675sjlf	660	7	an	an	DT
cord-022313-2675sjlf	660	8	inhibitor	inhibitor	NN
cord-022313-2675sjlf	660	9	of	of	IN
cord-022313-2675sjlf	660	10	lipid	lipid	NN
cord-022313-2675sjlf	660	11	-	-	HYPH
cord-022313-2675sjlf	660	12	linked	link	VBN
cord-022313-2675sjlf	660	13	saccharide	saccharide	NN
cord-022313-2675sjlf	660	14	formation	formation	NN
cord-022313-2675sjlf	660	15	and	and	CC
cord-022313-2675sjlf	660	16	to	to	TO
cord-022313-2675sjlf	660	17	cause	cause	VB
cord-022313-2675sjlf	660	18	the	the	DT
cord-022313-2675sjlf	660	19	production	production	NN
cord-022313-2675sjlf	660	20	of	of	IN
cord-022313-2675sjlf	660	21	truncated	truncated	JJ
cord-022313-2675sjlf	660	22	lipid	lipid	NN
cord-022313-2675sjlf	660	23	-	-	HYPH
cord-022313-2675sjlf	660	24	linked	link	VBN
cord-022313-2675sjlf	660	25	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	660	26	in	in	IN
cord-022313-2675sjlf	660	27	MDCK	MDCK	NNP
cord-022313-2675sjlf	660	28	cells	cell	NNS
cord-022313-2675sjlf	660	29	incubated	incubate	VBN
cord-022313-2675sjlf	660	30	with	with	IN
cord-022313-2675sjlf	660	31	micromolar	micromolar	JJ
cord-022313-2675sjlf	660	32	concentrations	concentration	NNS
cord-022313-2675sjlf	660	33	of	of	IN
cord-022313-2675sjlf	660	34	this	this	DT
cord-022313-2675sjlf	660	35	compound	compound	NN
cord-022313-2675sjlf	660	36	(	(	-LRB-
cord-022313-2675sjlf	660	37	156	156	CD
cord-022313-2675sjlf	660	38	)	)	-RRB-
cord-022313-2675sjlf	660	39	.	.	.
cord-022313-2675sjlf	661	1	When	when	WRB
cord-022313-2675sjlf	661	2	mannosamine	mannosamine	NNP
cord-022313-2675sjlf	661	3	was	be	VBD
cord-022313-2675sjlf	661	4	included	include	VBN
cord-022313-2675sjlf	661	5	in	in	IN
cord-022313-2675sjlf	661	6	the	the	DT
cord-022313-2675sjlf	661	7	growth	growth	NN
cord-022313-2675sjlf	661	8	medium	medium	NN
cord-022313-2675sjlf	661	9	of	of	IN
cord-022313-2675sjlf	661	10	MDCK	MDCK	NNP
cord-022313-2675sjlf	661	11	cells	cell	NNS
cord-022313-2675sjlf	661	12	,	,	,
cord-022313-2675sjlf	661	13	it	-PRON-	PRP
cord-022313-2675sjlf	661	14	blocked	block	VBD
cord-022313-2675sjlf	661	15	the	the	DT
cord-022313-2675sjlf	661	16	incorporation	incorporation	NN
cord-022313-2675sjlf	661	17	of	of	IN
cord-022313-2675sjlf	661	18	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NNP
cord-022313-2675sjlf	661	19	into	into	IN
cord-022313-2675sjlf	661	20	GPI	GPI	NNP
cord-022313-2675sjlf	661	21	-	-	HYPH
cord-022313-2675sjlf	661	22	anchored	anchor	VBN
cord-022313-2675sjlf	661	23	pro	pro	JJ
cord-022313-2675sjlf	661	24	teins	tein	NNS
cord-022313-2675sjlf	661	25	.	.	.
cord-022313-2675sjlf	662	1	Thus	thus	RB
cord-022313-2675sjlf	662	2	,	,	,
cord-022313-2675sjlf	662	3	in	in	IN
cord-022313-2675sjlf	662	4	polarized	polarized	JJ
cord-022313-2675sjlf	662	5	MDCK	MDCK	NNP
cord-022313-2675sjlf	662	6	cell	cell	NN
cord-022313-2675sjlf	662	7	cultures	culture	NNS
cord-022313-2675sjlf	662	8	,	,	,
cord-022313-2675sjlf	662	9	this	this	DT
cord-022313-2675sjlf	662	10	amino	amino	NN
cord-022313-2675sjlf	662	11	-	-	HYPH
cord-022313-2675sjlf	662	12	sugar	sugar	NN
cord-022313-2675sjlf	662	13	markedely	markedely	RB
cord-022313-2675sjlf	662	14	reduced	reduce	VBD
cord-022313-2675sjlf	662	15	the	the	DT
cord-022313-2675sjlf	662	16	appearance	appearance	NN
cord-022313-2675sjlf	662	17	at	at	IN
cord-022313-2675sjlf	662	18	the	the	DT
cord-022313-2675sjlf	662	19	cell	cell	NN
cord-022313-2675sjlf	662	20	surface	surface	NN
cord-022313-2675sjlf	662	21	of	of	IN
cord-022313-2675sjlf	662	22	a	a	DT
cord-022313-2675sjlf	662	23	recombinant	recombinant	JJ
cord-022313-2675sjlf	662	24	GPI	GPI	NNP
cord-022313-2675sjlf	662	25	-	-	HYPH
cord-022313-2675sjlf	662	26	anchored	anchor	VBN
cord-022313-2675sjlf	662	27	protein	protein	NN
cord-022313-2675sjlf	662	28	and	and	CC
cord-022313-2675sjlf	662	29	converted	convert	VBD
cord-022313-2675sjlf	662	30	this	this	DT
cord-022313-2675sjlf	662	31	apically	apically	RB
cord-022313-2675sjlf	662	32	oriented	orient	VBN
cord-022313-2675sjlf	662	33	membrane	membrane	NN
cord-022313-2675sjlf	662	34	protein	protein	NN
cord-022313-2675sjlf	662	35	to	to	IN
cord-022313-2675sjlf	662	36	an	an	DT
cord-022313-2675sjlf	662	37	unpolarized	unpolarized	JJ
cord-022313-2675sjlf	662	38	secretory	secretory	JJ
cord-022313-2675sjlf	662	39	protein	protein	NN
cord-022313-2675sjlf	662	40	.	.	.
cord-022313-2675sjlf	663	1	It	-PRON-	PRP
cord-022313-2675sjlf	663	2	also	also	RB
cord-022313-2675sjlf	663	3	blocked	block	VBD
cord-022313-2675sjlf	663	4	the	the	DT
cord-022313-2675sjlf	663	5	surface	surface	NN
cord-022313-2675sjlf	663	6	appearance	appearance	NN
cord-022313-2675sjlf	663	7	of	of	IN
cord-022313-2675sjlf	663	8	other	other	JJ
cord-022313-2675sjlf	663	9	endogenous	endogenous	JJ
cord-022313-2675sjlf	663	10	GPI	GPI	NNP
cord-022313-2675sjlf	663	11	-	-	HYPH
cord-022313-2675sjlf	663	12	anchored	anchor	VBN
cord-022313-2675sjlf	663	13	proteins	protein	NNS
cord-022313-2675sjlf	663	14	.	.	.
cord-022313-2675sjlf	664	1	In	in	IN
cord-022313-2675sjlf	664	2	this	this	DT
cord-022313-2675sjlf	664	3	system	system	NN
cord-022313-2675sjlf	664	4	,	,	,
cord-022313-2675sjlf	664	5	mannosamine	mannosamine	NNP
cord-022313-2675sjlf	664	6	also	also	RB
cord-022313-2675sjlf	664	7	inhibited	inhibit	VBD
cord-022313-2675sjlf	664	8	the	the	DT
cord-022313-2675sjlf	664	9	incorporation	incorporation	NN
cord-022313-2675sjlf	664	10	of	of	IN
cord-022313-2675sjlf	664	11	[	[	-LRB-
cord-022313-2675sjlf	664	12	3	3	CD
cord-022313-2675sjlf	664	13	H]ethanolamine	H]ethanolamine	NNP
cord-022313-2675sjlf	664	14	into	into	IN
cord-022313-2675sjlf	664	15	GPI	GPI	NNP
cord-022313-2675sjlf	664	16	-	-	HYPH
cord-022313-2675sjlf	664	17	anchored	anchor	VBN
cord-022313-2675sjlf	664	18	proteins	protein	NNS
cord-022313-2675sjlf	664	19	and	and	CC
cord-022313-2675sjlf	664	20	GPI	GPI	NNP
cord-022313-2675sjlf	664	21	intermediates	intermediate	NNS
cord-022313-2675sjlf	664	22	,	,	,
cord-022313-2675sjlf	664	23	suggesting	suggest	VBG
cord-022313-2675sjlf	664	24	that	that	IN
cord-022313-2675sjlf	664	25	this	this	DT
cord-022313-2675sjlf	664	26	amino	amino	NN
cord-022313-2675sjlf	664	27	-	-	HYPH
cord-022313-2675sjlf	664	28	sugar	sugar	NN
cord-022313-2675sjlf	664	29	inhibits	inhibit	VBZ
cord-022313-2675sjlf	664	30	the	the	DT
cord-022313-2675sjlf	664	31	assembly	assembly	NN
cord-022313-2675sjlf	664	32	of	of	IN
cord-022313-2675sjlf	664	33	the	the	DT
cord-022313-2675sjlf	664	34	glycan	glycan	NN
cord-022313-2675sjlf	664	35	portion	portion	NN
cord-022313-2675sjlf	664	36	of	of	IN
cord-022313-2675sjlf	664	37	the	the	DT
cord-022313-2675sjlf	664	38	anchor	anchor	NN
cord-022313-2675sjlf	664	39	(	(	-LRB-
cord-022313-2675sjlf	664	40	263	263	CD
cord-022313-2675sjlf	664	41	)	)	-RRB-
cord-022313-2675sjlf	664	42	.	.	.
cord-022313-2675sjlf	665	1	The	the	DT
cord-022313-2675sjlf	665	2	effect	effect	NN
cord-022313-2675sjlf	665	3	of	of	IN
cord-022313-2675sjlf	665	4	mannosamine	mannosamine	NN
cord-022313-2675sjlf	665	5	on	on	IN
cord-022313-2675sjlf	665	6	the	the	DT
cord-022313-2675sjlf	665	7	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	665	8	of	of	IN
cord-022313-2675sjlf	665	9	intermediates	intermediate	NNS
cord-022313-2675sjlf	665	10	in	in	IN
cord-022313-2675sjlf	665	11	volved	volved	NN
cord-022313-2675sjlf	665	12	in	in	IN
cord-022313-2675sjlf	665	13	anchor	anchor	NN
cord-022313-2675sjlf	665	14	formation	formation	NN
cord-022313-2675sjlf	665	15	was	be	VBD
cord-022313-2675sjlf	665	16	also	also	RB
cord-022313-2675sjlf	665	17	examined	examine	VBN
cord-022313-2675sjlf	665	18	in	in	IN
cord-022313-2675sjlf	665	19	MDCK	MDCK	NNP
cord-022313-2675sjlf	665	20	cell	cell	NN
cord-022313-2675sjlf	665	21	cultures	culture	NNS
cord-022313-2675sjlf	665	22	by	by	IN
cord-022313-2675sjlf	665	23	incubating	incubate	VBG
cord-022313-2675sjlf	665	24	these	these	DT
cord-022313-2675sjlf	665	25	cells	cell	NNS
cord-022313-2675sjlf	665	26	with	with	IN
cord-022313-2675sjlf	665	27	[	[	-LRB-
cord-022313-2675sjlf	665	28	2	2	CD
cord-022313-2675sjlf	665	29	-	-	SYM
cord-022313-2675sjlf	665	30	3	3	CD
cord-022313-2675sjlf	665	31	H]mannose	H]mannose	NNP
cord-022313-2675sjlf	665	32	in	in	IN
cord-022313-2675sjlf	665	33	the	the	DT
cord-022313-2675sjlf	665	34	presence	presence	NN
cord-022313-2675sjlf	665	35	of	of	IN
cord-022313-2675sjlf	665	36	various	various	JJ
cord-022313-2675sjlf	665	37	amounts	amount	NNS
cord-022313-2675sjlf	665	38	of	of	IN
cord-022313-2675sjlf	665	39	mannosamine	mannosamine	NN
cord-022313-2675sjlf	665	40	.	.	.
cord-022313-2675sjlf	666	1	This	this	DT
cord-022313-2675sjlf	666	2	amino	amino	NN
cord-022313-2675sjlf	666	3	-	-	HYPH
cord-022313-2675sjlf	666	4	sugar	sugar	NN
cord-022313-2675sjlf	666	5	inhibited	inhibit	VBD
cord-022313-2675sjlf	666	6	the	the	DT
cord-022313-2675sjlf	666	7	incorpora	incorpora	NNP
cord-022313-2675sjlf	666	8	tion	tion	NN
cord-022313-2675sjlf	666	9	of	of	IN
cord-022313-2675sjlf	666	10	mannose	mannose	NN
cord-022313-2675sjlf	666	11	into	into	IN
cord-022313-2675sjlf	666	12	GPI	GPI	NNP
cord-022313-2675sjlf	666	13	intermediates	intermediate	NNS
cord-022313-2675sjlf	666	14	in	in	IN
cord-022313-2675sjlf	666	15	a	a	DT
cord-022313-2675sjlf	666	16	dose	dose	NN
cord-022313-2675sjlf	666	17	-	-	HYPH
cord-022313-2675sjlf	666	18	dependent	dependent	JJ
cord-022313-2675sjlf	666	19	and	and	CC
cord-022313-2675sjlf	666	20	revers	revers	FW
cord-022313-2675sjlf	666	21	ible	ible	JJ
cord-022313-2675sjlf	666	22	manner	manner	NN
cord-022313-2675sjlf	666	23	.	.	.
cord-022313-2675sjlf	667	1	Mannosamine	Mannosamine	NNP
cord-022313-2675sjlf	667	2	was	be	VBD
cord-022313-2675sjlf	667	3	shown	show	VBN
cord-022313-2675sjlf	667	4	to	to	TO
cord-022313-2675sjlf	667	5	be	be	VB
cord-022313-2675sjlf	667	6	incorporated	incorporate	VBN
cord-022313-2675sjlf	667	7	into	into	IN
cord-022313-2675sjlf	667	8	the	the	DT
cord-022313-2675sjlf	667	9	glycan	glycan	NN
cord-022313-2675sjlf	667	10	as	as	IN
cord-022313-2675sjlf	667	11	mannosamine	mannosamine	NNP
cord-022313-2675sjlf	667	12	and	and	CC
cord-022313-2675sjlf	667	13	probably	probably	RB
cord-022313-2675sjlf	667	14	mostly	mostly	RB
cord-022313-2675sjlf	667	15	in	in	IN
cord-022313-2675sjlf	667	16	the	the	DT
cord-022313-2675sjlf	667	17	second	second	JJ
cord-022313-2675sjlf	667	18	mannose	mannose	NN
cord-022313-2675sjlf	667	19	position	position	NN
cord-022313-2675sjlf	667	20	.	.	.
cord-022313-2675sjlf	668	1	Thus	thus	RB
cord-022313-2675sjlf	668	2	,	,	,
cord-022313-2675sjlf	668	3	it	-PRON-	PRP
cord-022313-2675sjlf	668	4	appears	appear	VBZ
cord-022313-2675sjlf	668	5	to	to	TO
cord-022313-2675sjlf	668	6	block	block	VB
cord-022313-2675sjlf	668	7	further	further	JJ
cord-022313-2675sjlf	668	8	addition	addition	NN
cord-022313-2675sjlf	668	9	of	of	IN
cord-022313-2675sjlf	668	10	mannose	mannose	NN
cord-022313-2675sjlf	668	11	because	because	IN
cord-022313-2675sjlf	668	12	the	the	DT
cord-022313-2675sjlf	668	13	next	next	JJ
cord-022313-2675sjlf	668	14	mannose	mannose	NN
cord-022313-2675sjlf	668	15	is	be	VBZ
cord-022313-2675sjlf	668	16	attached	attach	VBN
cord-022313-2675sjlf	668	17	to	to	IN
cord-022313-2675sjlf	668	18	the	the	DT
cord-022313-2675sjlf	668	19	2-hydroxyl	2-hydroxyl	CD
cord-022313-2675sjlf	668	20	of	of	IN
cord-022313-2675sjlf	668	21	this	this	DT
cord-022313-2675sjlf	668	22	second	second	JJ
cord-022313-2675sjlf	668	23	mannose	mannose	NN
cord-022313-2675sjlf	668	24	.	.	.
cord-022313-2675sjlf	669	1	Various	various	JJ
cord-022313-2675sjlf	669	2	smaller	small	JJR
cord-022313-2675sjlf	669	3	sized	sized	JJ
cord-022313-2675sjlf	669	4	intermediates	intermediate	NNS
cord-022313-2675sjlf	669	5	were	be	VBD
cord-022313-2675sjlf	669	6	detected	detect	VBN
cord-022313-2675sjlf	669	7	in	in	IN
cord-022313-2675sjlf	669	8	cells	cell	NNS
cord-022313-2675sjlf	669	9	incubated	incubate	VBN
cord-022313-2675sjlf	669	10	in	in	IN
cord-022313-2675sjlf	669	11	the	the	DT
cord-022313-2675sjlf	669	12	presence	presence	NN
cord-022313-2675sjlf	669	13	of	of	IN
cord-022313-2675sjlf	669	14	this	this	DT
cord-022313-2675sjlf	669	15	drug	drug	NN
cord-022313-2675sjlf	669	16	.	.	.
cord-022313-2675sjlf	670	1	As	as	IN
cord-022313-2675sjlf	670	2	a	a	DT
cord-022313-2675sjlf	670	3	result	result	NN
cord-022313-2675sjlf	670	4	,	,	,
cord-022313-2675sjlf	670	5	ethanolamine	ethanolamine	NN
cord-022313-2675sjlf	670	6	-	-	HYPH
cord-022313-2675sjlf	670	7	P	p	NN
cord-022313-2675sjlf	670	8	could	could	MD
cord-022313-2675sjlf	670	9	not	not	RB
cord-022313-2675sjlf	670	10	be	be	VB
cord-022313-2675sjlf	670	11	added	add	VBN
cord-022313-2675sjlf	670	12	,	,	,
cord-022313-2675sjlf	670	13	nor	nor	CC
cord-022313-2675sjlf	670	14	could	could	MD
cord-022313-2675sjlf	670	15	the	the	DT
cord-022313-2675sjlf	670	16	protein	protein	NN
cord-022313-2675sjlf	670	17	be	be	VB
cord-022313-2675sjlf	670	18	transferred	transfer	VBN
cord-022313-2675sjlf	670	19	to	to	IN
cord-022313-2675sjlf	670	20	this	this	DT
cord-022313-2675sjlf	670	21	anchor	anchor	NN
cord-022313-2675sjlf	670	22	.	.	.
cord-022313-2675sjlf	671	1	This	this	DT
cord-022313-2675sjlf	671	2	inhibi	inhibi	NNS
cord-022313-2675sjlf	671	3	tion	tion	NN
cord-022313-2675sjlf	671	4	was	be	VBD
cord-022313-2675sjlf	671	5	specific	specific	JJ
cord-022313-2675sjlf	671	6	for	for	IN
cord-022313-2675sjlf	671	7	mannosamine	mannosamine	NN
cord-022313-2675sjlf	671	8	,	,	,
cord-022313-2675sjlf	671	9	and	and	CC
cord-022313-2675sjlf	671	10	other	other	JJ
cord-022313-2675sjlf	671	11	amino	amino	NNS
cord-022313-2675sjlf	671	12	-	-	HYPH
cord-022313-2675sjlf	671	13	sugars	sugar	NNS
cord-022313-2675sjlf	671	14	such	such	JJ
cord-022313-2675sjlf	671	15	as	as	IN
cord-022313-2675sjlf	671	16	galactosamine	galactosamine	NNP
cord-022313-2675sjlf	671	17	and	and	CC
cord-022313-2675sjlf	671	18	trehalosamine	trehalosamine	NNP
cord-022313-2675sjlf	671	19	were	be	VBD
cord-022313-2675sjlf	671	20	not	not	RB
cord-022313-2675sjlf	671	21	inhibitory	inhibitory	JJ
cord-022313-2675sjlf	671	22	(	(	-LRB-
cord-022313-2675sjlf	671	23	264	264	CD
cord-022313-2675sjlf	671	24	)	)	-RRB-
cord-022313-2675sjlf	671	25	.	.	.
cord-022313-2675sjlf	672	1	Further	further	JJ
cord-022313-2675sjlf	672	2	studies	study	NNS
cord-022313-2675sjlf	672	3	with	with	IN
cord-022313-2675sjlf	672	4	mannosamine	mannosamine	NN
cord-022313-2675sjlf	672	5	or	or	CC
cord-022313-2675sjlf	672	6	with	with	IN
cord-022313-2675sjlf	672	7	other	other	JJ
cord-022313-2675sjlf	672	8	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	672	9	as	as	IN
cord-022313-2675sjlf	672	10	they	-PRON-	PRP
cord-022313-2675sjlf	672	11	become	become	VBP
cord-022313-2675sjlf	672	12	known	know	VBN
cord-022313-2675sjlf	672	13	should	should	MD
cord-022313-2675sjlf	672	14	help	help	VB
cord-022313-2675sjlf	672	15	us	-PRON-	PRP
cord-022313-2675sjlf	672	16	to	to	TO
cord-022313-2675sjlf	672	17	understand	understand	VB
cord-022313-2675sjlf	672	18	the	the	DT
cord-022313-2675sjlf	672	19	physiological	physiological	JJ
cord-022313-2675sjlf	672	20	significance	significance	NN
cord-022313-2675sjlf	672	21	of	of	IN
cord-022313-2675sjlf	672	22	this	this	DT
cord-022313-2675sjlf	672	23	anchoring	anchor	VBG
cord-022313-2675sjlf	672	24	mechanism	mechanism	NN
cord-022313-2675sjlf	672	25	.	.	.
cord-022313-2675sjlf	673	1	Inhibitors	inhibitor	NNS
cord-022313-2675sjlf	673	2	are	be	VBP
cord-022313-2675sjlf	673	3	certainly	certainly	RB
cord-022313-2675sjlf	673	4	not	not	RB
cord-022313-2675sjlf	673	5	a	a	DT
cord-022313-2675sjlf	673	6	panacea	panacea	NN
cord-022313-2675sjlf	673	7	for	for	IN
cord-022313-2675sjlf	673	8	all	all	DT
cord-022313-2675sjlf	673	9	biochemical	biochemical	JJ
cord-022313-2675sjlf	673	10	studies	study	NNS
cord-022313-2675sjlf	673	11	,	,	,
cord-022313-2675sjlf	673	12	and	and	CC
cord-022313-2675sjlf	673	13	as	as	IN
cord-022313-2675sjlf	673	14	indicated	indicate	VBN
cord-022313-2675sjlf	673	15	earlier	early	RBR
cord-022313-2675sjlf	673	16	there	there	EX
cord-022313-2675sjlf	673	17	are	be	VBP
cord-022313-2675sjlf	673	18	potential	potential	JJ
cord-022313-2675sjlf	673	19	problems	problem	NNS
cord-022313-2675sjlf	673	20	in	in	IN
cord-022313-2675sjlf	673	21	their	-PRON-	PRP$
cord-022313-2675sjlf	673	22	utiliza	utiliza	NNP
cord-022313-2675sjlf	673	23	tion	tion	NN
cord-022313-2675sjlf	673	24	,	,	,
cord-022313-2675sjlf	673	25	such	such	JJ
cord-022313-2675sjlf	673	26	as	as	IN
cord-022313-2675sjlf	673	27	lack	lack	NN
cord-022313-2675sjlf	673	28	of	of	IN
cord-022313-2675sjlf	673	29	specificity	specificity	NN
cord-022313-2675sjlf	673	30	or	or	CC
cord-022313-2675sjlf	673	31	interference	interference	NN
cord-022313-2675sjlf	673	32	with	with	IN
cord-022313-2675sjlf	673	33	other	other	JJ
cord-022313-2675sjlf	673	34	key	key	JJ
cord-022313-2675sjlf	673	35	reactions	reaction	NNS
cord-022313-2675sjlf	673	36	.	.	.
cord-022313-2675sjlf	674	1	Nevertheless	nevertheless	RB
cord-022313-2675sjlf	674	2	,	,	,
cord-022313-2675sjlf	674	3	they	-PRON-	PRP
cord-022313-2675sjlf	674	4	can	can	MD
cord-022313-2675sjlf	674	5	provide	provide	VB
cord-022313-2675sjlf	674	6	valuable	valuable	JJ
cord-022313-2675sjlf	674	7	insights	insight	NNS
cord-022313-2675sjlf	674	8	into	into	IN
cord-022313-2675sjlf	674	9	understanding	understand	VBG
cord-022313-2675sjlf	674	10	specific	specific	JJ
cord-022313-2675sjlf	674	11	steps	step	NNS
cord-022313-2675sjlf	674	12	in	in	IN
cord-022313-2675sjlf	674	13	a	a	DT
cord-022313-2675sjlf	674	14	biochemical	biochemical	JJ
cord-022313-2675sjlf	674	15	pathway	pathway	NN
cord-022313-2675sjlf	674	16	as	as	RB
cord-022313-2675sjlf	674	17	well	well	RB
cord-022313-2675sjlf	674	18	as	as	IN
cord-022313-2675sjlf	674	19	in	in	IN
cord-022313-2675sjlf	674	20	determining	determine	VBG
cord-022313-2675sjlf	674	21	the	the	DT
cord-022313-2675sjlf	674	22	physiological	physiological	JJ
cord-022313-2675sjlf	674	23	function	function	NN
cord-022313-2675sjlf	674	24	of	of	IN
cord-022313-2675sjlf	674	25	various	various	JJ
cord-022313-2675sjlf	674	26	biochemical	biochemical	JJ
cord-022313-2675sjlf	674	27	molecules	molecule	NNS
cord-022313-2675sjlf	674	28	.	.	.
cord-022313-2675sjlf	675	1	For	for	IN
cord-022313-2675sjlf	675	2	example	example	NN
cord-022313-2675sjlf	675	3	,	,	,
cord-022313-2675sjlf	675	4	in	in	IN
cord-022313-2675sjlf	675	5	terms	term	NNS
cord-022313-2675sjlf	675	6	of	of	IN
cord-022313-2675sjlf	675	7	the	the	DT
cord-022313-2675sjlf	675	8	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	675	9	of	of	IN
cord-022313-2675sjlf	675	10	the	the	DT
cord-022313-2675sjlf	675	11	N	N	NNP
cord-022313-2675sjlf	675	12	-	-	HYPH
cord-022313-2675sjlf	675	13	linked	link	VBN
cord-022313-2675sjlf	675	14	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	675	15	,	,	,
cord-022313-2675sjlf	675	16	inhibi	inhibi	NNP
cord-022313-2675sjlf	675	17	tors	tor	NNS
cord-022313-2675sjlf	675	18	of	of	IN
cord-022313-2675sjlf	675	19	the	the	DT
cord-022313-2675sjlf	675	20	lipid	lipid	NN
cord-022313-2675sjlf	675	21	-	-	HYPH
cord-022313-2675sjlf	675	22	linked	link	VBN
cord-022313-2675sjlf	675	23	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	675	24	pathway	pathway	NN
cord-022313-2675sjlf	675	25	,	,	,
cord-022313-2675sjlf	675	26	such	such	JJ
cord-022313-2675sjlf	675	27	as	as	IN
cord-022313-2675sjlf	675	28	amphomycin	amphomycin	NNS
cord-022313-2675sjlf	675	29	,	,	,
cord-022313-2675sjlf	675	30	have	have	VBP
cord-022313-2675sjlf	675	31	helped	help	VBN
cord-022313-2675sjlf	675	32	to	to	TO
cord-022313-2675sjlf	675	33	establish	establish	VB
cord-022313-2675sjlf	675	34	that	that	IN
cord-022313-2675sjlf	675	35	the	the	DT
cord-022313-2675sjlf	675	36	mannosyl	mannosyl	NNP
cord-022313-2675sjlf	675	37	donor	donor	NN
cord-022313-2675sjlf	675	38	for	for	IN
cord-022313-2675sjlf	675	39	the	the	DT
cord-022313-2675sjlf	675	40	last	last	JJ
cord-022313-2675sjlf	675	41	four	four	CD
cord-022313-2675sjlf	675	42	mannose	mannose	NN
cord-022313-2675sjlf	675	43	residues	residue	NNS
cord-022313-2675sjlf	675	44	of	of	IN
cord-022313-2675sjlf	675	45	the	the	DT
cord-022313-2675sjlf	675	46	Glc	Glc	NNP
cord-022313-2675sjlf	675	47	3	3	CD
cord-022313-2675sjlf	675	48	Man	Man	NNP
cord-022313-2675sjlf	675	49	9	9	CD
cord-022313-2675sjlf	675	50	(	(	-LRB-
cord-022313-2675sjlf	675	51	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	675	52	)	)	-RRB-
cord-022313-2675sjlf	675	53	2	2	CD
cord-022313-2675sjlf	675	54	-PP	-PP	NNS
cord-022313-2675sjlf	675	55	-	-	HYPH
cord-022313-2675sjlf	675	56	dolichol	dolichol	NNP
cord-022313-2675sjlf	675	57	was	be	VBD
cord-022313-2675sjlf	675	58	dolichyl	dolichyl	NN
cord-022313-2675sjlf	675	59	-	-	HYPH
cord-022313-2675sjlf	675	60	P	p	NN
cord-022313-2675sjlf	675	61	-	-	HYPH
cord-022313-2675sjlf	675	62	mannose	mannose	NN
cord-022313-2675sjlf	675	63	,	,	,
cord-022313-2675sjlf	675	64	rather	rather	RB
cord-022313-2675sjlf	675	65	than	than	IN
cord-022313-2675sjlf	675	66	GDP	gdp	NN
cord-022313-2675sjlf	675	67	-	-	HYPH
cord-022313-2675sjlf	675	68	mannose	mannose	NN
cord-022313-2675sjlf	675	69	.	.	.
cord-022313-2675sjlf	676	1	Other	other	JJ
cord-022313-2675sjlf	676	2	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	676	3	of	of	IN
cord-022313-2675sjlf	676	4	this	this	DT
cord-022313-2675sjlf	676	5	path	path	NN
cord-022313-2675sjlf	676	6	way	way	NN
cord-022313-2675sjlf	676	7	,	,	,
cord-022313-2675sjlf	676	8	such	such	JJ
cord-022313-2675sjlf	676	9	as	as	IN
cord-022313-2675sjlf	676	10	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	676	11	,	,	,
cord-022313-2675sjlf	676	12	have	have	VBP
cord-022313-2675sjlf	676	13	provided	provide	VBN
cord-022313-2675sjlf	676	14	evidence	evidence	NN
cord-022313-2675sjlf	676	15	to	to	TO
cord-022313-2675sjlf	676	16	suggest	suggest	VB
cord-022313-2675sjlf	676	17	that	that	IN
cord-022313-2675sjlf	676	18	the	the	DT
cord-022313-2675sjlf	676	19	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	676	20	portion	portion	NN
cord-022313-2675sjlf	676	21	of	of	IN
cord-022313-2675sjlf	676	22	the	the	DT
cord-022313-2675sjlf	676	23	asparagine	asparagine	NN
cord-022313-2675sjlf	676	24	-	-	HYPH
cord-022313-2675sjlf	676	25	linked	link	VBN
cord-022313-2675sjlf	676	26	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	676	27	may	may	MD
cord-022313-2675sjlf	676	28	play	play	VB
cord-022313-2675sjlf	676	29	a	a	DT
cord-022313-2675sjlf	676	30	number	number	NN
cord-022313-2675sjlf	676	31	of	of	IN
cord-022313-2675sjlf	676	32	different	different	JJ
cord-022313-2675sjlf	676	33	roles	role	NNS
cord-022313-2675sjlf	676	34	,	,	,
cord-022313-2675sjlf	676	35	including	include	VBG
cord-022313-2675sjlf	676	36	enhancing	enhance	VBG
cord-022313-2675sjlf	676	37	the	the	DT
cord-022313-2675sjlf	676	38	stability	stability	NN
cord-022313-2675sjlf	676	39	of	of	IN
cord-022313-2675sjlf	676	40	the	the	DT
cord-022313-2675sjlf	676	41	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	676	42	,	,	,
cord-022313-2675sjlf	676	43	affecting	affect	VBG
cord-022313-2675sjlf	676	44	the	the	DT
cord-022313-2675sjlf	676	45	conformation	conformation	NN
cord-022313-2675sjlf	676	46	of	of	IN
cord-022313-2675sjlf	676	47	the	the	DT
cord-022313-2675sjlf	676	48	protein	protein	NN
cord-022313-2675sjlf	676	49	,	,	,
cord-022313-2675sjlf	676	50	providing	provide	VBG
cord-022313-2675sjlf	676	51	a	a	DT
cord-022313-2675sjlf	676	52	recognition	recognition	NN
cord-022313-2675sjlf	676	53	signal	signal	NN
cord-022313-2675sjlf	676	54	for	for	IN
cord-022313-2675sjlf	676	55	targeting	target	VBG
cord-022313-2675sjlf	676	56	the	the	DT
cord-022313-2675sjlf	676	57	protein	protein	NN
cord-022313-2675sjlf	676	58	to	to	IN
cord-022313-2675sjlf	676	59	specific	specific	JJ
cord-022313-2675sjlf	676	60	sites	site	NNS
cord-022313-2675sjlf	676	61	in	in	IN
cord-022313-2675sjlf	676	62	the	the	DT
cord-022313-2675sjlf	676	63	cell	cell	NN
cord-022313-2675sjlf	676	64	or	or	CC
cord-022313-2675sjlf	676	65	to	to	TO
cord-022313-2675sjlf	676	66	uptake	uptake	NN
cord-022313-2675sjlf	676	67	from	from	IN
cord-022313-2675sjlf	676	68	the	the	DT
cord-022313-2675sjlf	676	69	circulation	circulation	NN
cord-022313-2675sjlf	676	70	,	,	,
cord-022313-2675sjlf	676	71	providing	provide	VBG
cord-022313-2675sjlf	676	72	a	a	DT
cord-022313-2675sjlf	676	73	receptor	receptor	NN
cord-022313-2675sjlf	676	74	molecule	molecule	NN
cord-022313-2675sjlf	676	75	for	for	IN
cord-022313-2675sjlf	676	76	cell	cell	NN
cord-022313-2675sjlf	676	77	-	-	HYPH
cord-022313-2675sjlf	676	78	cell	cell	NN
cord-022313-2675sjlf	676	79	adhesion	adhesion	NN
cord-022313-2675sjlf	676	80	or	or	CC
cord-022313-2675sjlf	676	81	interactions	interaction	NNS
cord-022313-2675sjlf	676	82	and	and	CC
cord-022313-2675sjlf	676	83	so	so	RB
cord-022313-2675sjlf	676	84	on	on	RB
cord-022313-2675sjlf	676	85	.	.	.
cord-022313-2675sjlf	677	1	The	the	DT
cord-022313-2675sjlf	677	2	actual	actual	JJ
cord-022313-2675sjlf	677	3	role	role	NN
cord-022313-2675sjlf	677	4	of	of	IN
cord-022313-2675sjlf	677	5	the	the	DT
cord-022313-2675sjlf	677	6	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	677	7	depends	depend	VBZ
cord-022313-2675sjlf	677	8	on	on	IN
cord-022313-2675sjlf	677	9	the	the	DT
cord-022313-2675sjlf	677	10	amino	amino	NN
cord-022313-2675sjlf	677	11	acid	acid	NN
cord-022313-2675sjlf	677	12	sequence	sequence	NN
cord-022313-2675sjlf	677	13	of	of	IN
cord-022313-2675sjlf	677	14	the	the	DT
cord-022313-2675sjlf	677	15	protein	protein	NN
cord-022313-2675sjlf	677	16	in	in	IN
cord-022313-2675sjlf	677	17	question	question	NN
cord-022313-2675sjlf	677	18	.	.	.
cord-022313-2675sjlf	678	1	The	the	DT
cord-022313-2675sjlf	678	2	second	second	JJ
cord-022313-2675sjlf	678	3	group	group	NN
cord-022313-2675sjlf	678	4	of	of	IN
cord-022313-2675sjlf	678	5	important	important	JJ
cord-022313-2675sjlf	678	6	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	678	7	are	be	VBP
cord-022313-2675sjlf	678	8	those	those	DT
cord-022313-2675sjlf	678	9	that	that	WDT
cord-022313-2675sjlf	678	10	affect	affect	VBP
cord-022313-2675sjlf	678	11	glycosidases	glycosidase	NNS
cord-022313-2675sjlf	678	12	.	.	.
cord-022313-2675sjlf	679	1	These	these	DT
cord-022313-2675sjlf	679	2	types	type	NNS
cord-022313-2675sjlf	679	3	of	of	IN
cord-022313-2675sjlf	679	4	enzymes	enzyme	NNS
cord-022313-2675sjlf	679	5	are	be	VBP
cord-022313-2675sjlf	679	6	widespread	widespread	JJ
cord-022313-2675sjlf	679	7	in	in	IN
cord-022313-2675sjlf	679	8	nature	nature	NN
cord-022313-2675sjlf	679	9	and	and	CC
cord-022313-2675sjlf	679	10	are	be	VBP
cord-022313-2675sjlf	679	11	in	in	IN
cord-022313-2675sjlf	679	12	volved	volved	NN
cord-022313-2675sjlf	679	13	in	in	IN
cord-022313-2675sjlf	679	14	many	many	JJ
cord-022313-2675sjlf	679	15	natural	natural	JJ
cord-022313-2675sjlf	679	16	processes	process	NNS
cord-022313-2675sjlf	679	17	such	such	JJ
cord-022313-2675sjlf	679	18	as	as	IN
cord-022313-2675sjlf	679	19	cell	cell	NN
cord-022313-2675sjlf	679	20	division	division	NN
cord-022313-2675sjlf	679	21	and	and	CC
cord-022313-2675sjlf	679	22	cell	cell	NN
cord-022313-2675sjlf	679	23	separa	separa	NNP
cord-022313-2675sjlf	679	24	tion	tion	NN
cord-022313-2675sjlf	679	25	,	,	,
cord-022313-2675sjlf	679	26	turnover	turnover	NN
cord-022313-2675sjlf	679	27	of	of	IN
cord-022313-2675sjlf	679	28	macromolecules	macromolecule	NNS
cord-022313-2675sjlf	679	29	,	,	,
cord-022313-2675sjlf	679	30	N	n	NN
cord-022313-2675sjlf	679	31	-	-	HYPH
cord-022313-2675sjlf	679	32	linked	link	VBN
cord-022313-2675sjlf	679	33	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	679	34	processing	processing	NN
cord-022313-2675sjlf	679	35	,	,	,
cord-022313-2675sjlf	679	36	and	and	CC
cord-022313-2675sjlf	679	37	so	so	RB
cord-022313-2675sjlf	679	38	on	on	RB
cord-022313-2675sjlf	679	39	.	.	.
cord-022313-2675sjlf	680	1	Thus	thus	RB
cord-022313-2675sjlf	680	2	,	,	,
cord-022313-2675sjlf	680	3	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	680	4	of	of	IN
cord-022313-2675sjlf	680	5	these	these	DT
cord-022313-2675sjlf	680	6	enzymes	enzyme	NNS
cord-022313-2675sjlf	680	7	have	have	VBP
cord-022313-2675sjlf	680	8	great	great	JJ
cord-022313-2675sjlf	680	9	potential	potential	NN
cord-022313-2675sjlf	680	10	for	for	IN
cord-022313-2675sjlf	680	11	use	use	NN
cord-022313-2675sjlf	680	12	as	as	IN
cord-022313-2675sjlf	680	13	biochemical	biochemical	JJ
cord-022313-2675sjlf	680	14	tools	tool	NNS
cord-022313-2675sjlf	680	15	or	or	CC
cord-022313-2675sjlf	680	16	even	even	RB
cord-022313-2675sjlf	680	17	as	as	IN
cord-022313-2675sjlf	680	18	therapeutic	therapeutic	JJ
cord-022313-2675sjlf	680	19	agents	agent	NNS
cord-022313-2675sjlf	680	20	,	,	,
cord-022313-2675sjlf	680	21	or	or	CC
cord-022313-2675sjlf	680	22	they	-PRON-	PRP
cord-022313-2675sjlf	680	23	may	may	MD
cord-022313-2675sjlf	680	24	also	also	RB
cord-022313-2675sjlf	680	25	be	be	VB
cord-022313-2675sjlf	680	26	lethal	lethal	JJ
cord-022313-2675sjlf	680	27	as	as	IN
cord-022313-2675sjlf	680	28	shown	show	VBN
cord-022313-2675sjlf	680	29	for	for	IN
cord-022313-2675sjlf	680	30	the	the	DT
cord-022313-2675sjlf	680	31	glucosidase	glucosidase	NN
cord-022313-2675sjlf	680	32	and	and	CC
cord-022313-2675sjlf	680	33	mannosidase	mannosidase	NNP
cord-022313-2675sjlf	680	34	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	680	35	castanospermine	castanospermine	NNP
cord-022313-2675sjlf	680	36	and	and	CC
cord-022313-2675sjlf	680	37	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	680	38	.	.	.
cord-022313-2675sjlf	681	1	Again	again	RB
cord-022313-2675sjlf	681	2	these	these	DT
cord-022313-2675sjlf	681	3	latter	latter	JJ
cord-022313-2675sjlf	681	4	compounds	compound	NNS
cord-022313-2675sjlf	681	5	have	have	VBP
cord-022313-2675sjlf	681	6	gained	gain	VBN
cord-022313-2675sjlf	681	7	widespread	widespread	JJ
cord-022313-2675sjlf	681	8	use	use	NN
cord-022313-2675sjlf	681	9	for	for	IN
cord-022313-2675sjlf	681	10	studies	study	NNS
cord-022313-2675sjlf	681	11	on	on	IN
cord-022313-2675sjlf	681	12	the	the	DT
cord-022313-2675sjlf	681	13	role	role	NN
cord-022313-2675sjlf	681	14	of	of	IN
cord-022313-2675sjlf	681	15	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	681	16	in	in	IN
cord-022313-2675sjlf	681	17	Nlinked	Nlinked	NNP
cord-022313-2675sjlf	681	18	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	681	19	function	function	NN
cord-022313-2675sjlf	681	20	.	.	.
cord-022313-2675sjlf	682	1	However	however	RB
cord-022313-2675sjlf	682	2	,	,	,
cord-022313-2675sjlf	682	3	all	all	DT
cord-022313-2675sjlf	682	4	of	of	IN
cord-022313-2675sjlf	682	5	these	these	DT
cord-022313-2675sjlf	682	6	studies	study	NNS
cord-022313-2675sjlf	682	7	point	point	VBP
cord-022313-2675sjlf	682	8	out	out	RP
cord-022313-2675sjlf	682	9	the	the	DT
cord-022313-2675sjlf	682	10	need	need	NN
cord-022313-2675sjlf	682	11	for	for	IN
cord-022313-2675sjlf	682	12	additional	additional	JJ
cord-022313-2675sjlf	682	13	inhibi	inhibi	NNS
cord-022313-2675sjlf	682	14	tors	tor	NNS
cord-022313-2675sjlf	682	15	as	as	RB
cord-022313-2675sjlf	682	16	well	well	RB
cord-022313-2675sjlf	682	17	as	as	IN
cord-022313-2675sjlf	682	18	for	for	IN
cord-022313-2675sjlf	682	19	structurally	structurally	RB
cord-022313-2675sjlf	682	20	different	different	JJ
cord-022313-2675sjlf	682	21	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	682	22	.	.	.
cord-022313-2675sjlf	683	1	That	that	RB
cord-022313-2675sjlf	683	2	is	is	RB
cord-022313-2675sjlf	683	3	,	,	,
cord-022313-2675sjlf	683	4	the	the	DT
cord-022313-2675sjlf	683	5	studies	study	NNS
cord-022313-2675sjlf	683	6	with	with	IN
cord-022313-2675sjlf	683	7	glycosidase	glycosidase	NNP
cord-022313-2675sjlf	683	8	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	683	9	have	have	VBP
cord-022313-2675sjlf	683	10	shown	show	VBN
cord-022313-2675sjlf	683	11	that	that	IN
cord-022313-2675sjlf	683	12	even	even	RB
cord-022313-2675sjlf	683	13	the	the	DT
cord-022313-2675sjlf	683	14	best	good	JJS
cord-022313-2675sjlf	683	15	of	of	IN
cord-022313-2675sjlf	683	16	these	these	DT
cord-022313-2675sjlf	683	17	compounds	compound	NNS
cord-022313-2675sjlf	683	18	is	be	VBZ
cord-022313-2675sjlf	683	19	still	still	RB
cord-022313-2675sjlf	683	20	somewhat	somewhat	RB
cord-022313-2675sjlf	683	21	nonspecific	nonspecific	JJ
cord-022313-2675sjlf	683	22	and	and	CC
cord-022313-2675sjlf	683	23	inhibits	inhibit	VBZ
cord-022313-2675sjlf	683	24	more	more	JJR
cord-022313-2675sjlf	683	25	than	than	IN
cord-022313-2675sjlf	683	26	one	one	CD
cord-022313-2675sjlf	683	27	enzyme	enzyme	NN
cord-022313-2675sjlf	683	28	.	.	.
cord-022313-2675sjlf	684	1	For	for	IN
cord-022313-2675sjlf	684	2	example	example	NN
cord-022313-2675sjlf	684	3	,	,	,
cord-022313-2675sjlf	684	4	castanospermine	castanospermine	NN
cord-022313-2675sjlf	684	5	inhibits	inhibit	VBZ
cord-022313-2675sjlf	684	6	the	the	DT
cord-022313-2675sjlf	684	7	processing	processing	NN
cord-022313-2675sjlf	684	8	enzymes	enzyme	NNS
cord-022313-2675sjlf	685	1	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	685	2	I	I	NNP
cord-022313-2675sjlf	685	3	and	and	CC
cord-022313-2675sjlf	685	4	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	685	5	II	II	NNP
cord-022313-2675sjlf	685	6	,	,	,
cord-022313-2675sjlf	685	7	as	as	RB
cord-022313-2675sjlf	685	8	well	well	RB
cord-022313-2675sjlf	685	9	as	as	IN
cord-022313-2675sjlf	685	10	lysosomal	lysosomal	JJ
cord-022313-2675sjlf	685	11	a	a	DT
cord-022313-2675sjlf	685	12	-	-	HYPH
cord-022313-2675sjlf	685	13	glucosidase	glucosidase	NN
cord-022313-2675sjlf	685	14	,	,	,
cord-022313-2675sjlf	685	15	and	and	CC
cord-022313-2675sjlf	685	16	other	other	JJ
cord-022313-2675sjlf	685	17	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	685	18	.	.	.
cord-022313-2675sjlf	686	1	Swainsonine	Swainsonine	NNP
cord-022313-2675sjlf	686	2	,	,	,
cord-022313-2675sjlf	686	3	which	which	WDT
cord-022313-2675sjlf	686	4	is	be	VBZ
cord-022313-2675sjlf	686	5	somewhat	somewhat	RB
cord-022313-2675sjlf	686	6	more	more	RBR
cord-022313-2675sjlf	686	7	specific	specific	JJ
cord-022313-2675sjlf	686	8	,	,	,
cord-022313-2675sjlf	686	9	still	still	RB
cord-022313-2675sjlf	686	10	inhibits	inhibit	VBZ
cord-022313-2675sjlf	686	11	mannosidase	mannosidase	NN
cord-022313-2675sjlf	686	12	II	II	NNP
cord-022313-2675sjlf	686	13	and	and	CC
cord-022313-2675sjlf	686	14	lysosomal	lysosomal	NN
cord-022313-2675sjlf	686	15	α	α	NN
cord-022313-2675sjlf	686	16	-	-	HYPH
cord-022313-2675sjlf	686	17	mannosidase	mannosidase	NN
cord-022313-2675sjlf	686	18	.	.	.
cord-022313-2675sjlf	687	1	Can	Can	MD
cord-022313-2675sjlf	687	2	we	-PRON-	PRP
cord-022313-2675sjlf	687	3	find	find	VB
cord-022313-2675sjlf	687	4	,	,	,
cord-022313-2675sjlf	687	5	or	or	CC
cord-022313-2675sjlf	687	6	synthesize	synthesize	VB
cord-022313-2675sjlf	687	7	,	,	,
cord-022313-2675sjlf	687	8	more	more	RBR
cord-022313-2675sjlf	687	9	specific	specific	JJ
cord-022313-2675sjlf	687	10	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	687	11	that	that	WDT
cord-022313-2675sjlf	687	12	act	act	VBP
cord-022313-2675sjlf	687	13	only	only	RB
cord-022313-2675sjlf	687	14	on	on	IN
cord-022313-2675sjlf	687	15	one	one	CD
cord-022313-2675sjlf	687	16	enzyme	enzyme	NN
cord-022313-2675sjlf	687	17	?	?	.
cord-022313-2675sjlf	688	1	Of	of	RB
cord-022313-2675sjlf	688	2	course	course	RB
cord-022313-2675sjlf	688	3	,	,	,
cord-022313-2675sjlf	688	4	the	the	DT
cord-022313-2675sjlf	688	5	answer	answer	NN
cord-022313-2675sjlf	688	6	to	to	IN
cord-022313-2675sjlf	688	7	that	that	DT
cord-022313-2675sjlf	688	8	question	question	NN
cord-022313-2675sjlf	688	9	is	be	VBZ
cord-022313-2675sjlf	688	10	not	not	RB
cord-022313-2675sjlf	688	11	known	know	VBN
cord-022313-2675sjlf	688	12	at	at	IN
cord-022313-2675sjlf	688	13	this	this	DT
cord-022313-2675sjlf	688	14	time	time	NN
cord-022313-2675sjlf	688	15	since	since	IN
cord-022313-2675sjlf	688	16	the	the	DT
cord-022313-2675sjlf	688	17	mechanism	mechanism	NN
cord-022313-2675sjlf	688	18	of	of	IN
cord-022313-2675sjlf	688	19	catalysis	catalysis	NN
cord-022313-2675sjlf	688	20	has	have	VBZ
cord-022313-2675sjlf	688	21	not	not	RB
cord-022313-2675sjlf	688	22	been	be	VBN
cord-022313-2675sjlf	688	23	demonstrated	demonstrate	VBN
cord-022313-2675sjlf	688	24	for	for	IN
cord-022313-2675sjlf	688	25	most	most	JJS
cord-022313-2675sjlf	688	26	of	of	IN
cord-022313-2675sjlf	688	27	these	these	DT
cord-022313-2675sjlf	688	28	enzymes	enzyme	NNS
cord-022313-2675sjlf	688	29	.	.	.
cord-022313-2675sjlf	689	1	However	however	RB
cord-022313-2675sjlf	689	2	,	,	,
cord-022313-2675sjlf	689	3	even	even	RB
cord-022313-2675sjlf	689	4	if	if	IN
cord-022313-2675sjlf	689	5	some	some	DT
cord-022313-2675sjlf	689	6	of	of	IN
cord-022313-2675sjlf	689	7	these	these	DT
cord-022313-2675sjlf	689	8	enzymes	enzyme	NNS
cord-022313-2675sjlf	689	9	share	share	VBP
cord-022313-2675sjlf	689	10	a	a	DT
cord-022313-2675sjlf	689	11	common	common	JJ
cord-022313-2675sjlf	689	12	catalytic	catalytic	JJ
cord-022313-2675sjlf	689	13	mechanism	mechanism	NN
cord-022313-2675sjlf	689	14	,	,	,
cord-022313-2675sjlf	689	15	it	-PRON-	PRP
cord-022313-2675sjlf	689	16	should	should	MD
cord-022313-2675sjlf	689	17	still	still	RB
cord-022313-2675sjlf	689	18	be	be	VB
cord-022313-2675sjlf	689	19	possible	possible	JJ
cord-022313-2675sjlf	689	20	to	to	TO
cord-022313-2675sjlf	689	21	narrow	narrow	VB
cord-022313-2675sjlf	689	22	the	the	DT
cord-022313-2675sjlf	689	23	site	site	NN
cord-022313-2675sjlf	689	24	of	of	IN
cord-022313-2675sjlf	689	25	action	action	NN
cord-022313-2675sjlf	689	26	of	of	IN
cord-022313-2675sjlf	689	27	these	these	DT
cord-022313-2675sjlf	689	28	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	689	29	to	to	IN
cord-022313-2675sjlf	689	30	groups	group	NNS
cord-022313-2675sjlf	689	31	of	of	IN
cord-022313-2675sjlf	689	32	similarly	similarly	RB
cord-022313-2675sjlf	689	33	acting	act	VBG
cord-022313-2675sjlf	689	34	enzymes	enzyme	NNS
cord-022313-2675sjlf	689	35	.	.	.
cord-022313-2675sjlf	690	1	Since	since	IN
cord-022313-2675sjlf	690	2	there	there	EX
cord-022313-2675sjlf	690	3	are	be	VBP
cord-022313-2675sjlf	690	4	now	now	RB
cord-022313-2675sjlf	690	5	several	several	JJ
cord-022313-2675sjlf	690	6	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	690	7	that	that	WDT
cord-022313-2675sjlf	690	8	appear	appear	VBP
cord-022313-2675sjlf	690	9	to	to	TO
cord-022313-2675sjlf	690	10	distinguish	distinguish	VB
cord-022313-2675sjlf	690	11	between	between	IN
cord-022313-2675sjlf	690	12	glucosidase	glucosidase	NN
cord-022313-2675sjlf	690	13	I	I	NNP
cord-022313-2675sjlf	690	14	and	and	CC
cord-022313-2675sjlf	690	15	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	690	16	II	II	NNP
cord-022313-2675sjlf	690	17	,	,	,
cord-022313-2675sjlf	690	18	these	these	DT
cord-022313-2675sjlf	690	19	two	two	CD
cord-022313-2675sjlf	690	20	enzymes	enzyme	NNS
cord-022313-2675sjlf	690	21	must	must	MD
cord-022313-2675sjlf	690	22	differ	differ	VB
cord-022313-2675sjlf	690	23	in	in	IN
cord-022313-2675sjlf	690	24	their	-PRON-	PRP$
cord-022313-2675sjlf	690	25	catalytic	catalytic	JJ
cord-022313-2675sjlf	690	26	mechanism	mechanism	NN
cord-022313-2675sjlf	690	27	or	or	CC
cord-022313-2675sjlf	690	28	in	in	IN
cord-022313-2675sjlf	690	29	their	-PRON-	PRP$
cord-022313-2675sjlf	690	30	active	active	JJ
cord-022313-2675sjlf	690	31	site	site	NN
cord-022313-2675sjlf	690	32	.	.	.
cord-022313-2675sjlf	691	1	Thus	thus	RB
cord-022313-2675sjlf	691	2	,	,	,
cord-022313-2675sjlf	691	3	such	such	JJ
cord-022313-2675sjlf	691	4	studies	study	NNS
cord-022313-2675sjlf	691	5	provide	provide	VBP
cord-022313-2675sjlf	691	6	hope	hope	NN
cord-022313-2675sjlf	691	7	that	that	IN
cord-022313-2675sjlf	691	8	more	more	JJR
cord-022313-2675sjlf	691	9	specificity	specificity	NN
cord-022313-2675sjlf	691	10	can	can	MD
cord-022313-2675sjlf	691	11	be	be	VB
cord-022313-2675sjlf	691	12	obtained	obtain	VBN
cord-022313-2675sjlf	691	13	with	with	IN
cord-022313-2675sjlf	691	14	the	the	DT
cord-022313-2675sjlf	691	15	right	right	JJ
cord-022313-2675sjlf	691	16	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	691	17	.	.	.
cord-022313-2675sjlf	692	1	How	how	WRB
cord-022313-2675sjlf	692	2	can	can	MD
cord-022313-2675sjlf	692	3	we	-PRON-	PRP
cord-022313-2675sjlf	692	4	find	find	VB
cord-022313-2675sjlf	692	5	better	well	JJR
cord-022313-2675sjlf	692	6	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	692	7	?	?	.
cord-022313-2675sjlf	693	1	It	-PRON-	PRP
cord-022313-2675sjlf	693	2	seems	seem	VBZ
cord-022313-2675sjlf	693	3	that	that	IN
cord-022313-2675sjlf	693	4	there	there	EX
cord-022313-2675sjlf	693	5	are	be	VBP
cord-022313-2675sjlf	693	6	a	a	DT
cord-022313-2675sjlf	693	7	number	number	NN
cord-022313-2675sjlf	693	8	of	of	IN
cord-022313-2675sjlf	693	9	approaches	approach	NNS
cord-022313-2675sjlf	693	10	that	that	WDT
cord-022313-2675sjlf	693	11	could	could	MD
cord-022313-2675sjlf	693	12	be	be	VB
cord-022313-2675sjlf	693	13	used	use	VBN
cord-022313-2675sjlf	693	14	.	.	.
cord-022313-2675sjlf	694	1	One	one	CD
cord-022313-2675sjlf	694	2	of	of	IN
cord-022313-2675sjlf	694	3	the	the	DT
cord-022313-2675sjlf	694	4	most	most	RBS
cord-022313-2675sjlf	694	5	logical	logical	JJ
cord-022313-2675sjlf	694	6	,	,	,
cord-022313-2675sjlf	694	7	of	of	IN
cord-022313-2675sjlf	694	8	course	course	NN
cord-022313-2675sjlf	694	9	,	,	,
cord-022313-2675sjlf	694	10	would	would	MD
cord-022313-2675sjlf	694	11	be	be	VB
cord-022313-2675sjlf	694	12	to	to	TO
cord-022313-2675sjlf	694	13	work	work	VB
cord-022313-2675sjlf	694	14	out	out	RP
cord-022313-2675sjlf	694	15	and	and	CC
cord-022313-2675sjlf	694	16	understand	understand	VB
cord-022313-2675sjlf	694	17	the	the	DT
cord-022313-2675sjlf	694	18	catalytic	catalytic	JJ
cord-022313-2675sjlf	694	19	mechanism	mechanism	NN
cord-022313-2675sjlf	694	20	of	of	IN
cord-022313-2675sjlf	694	21	each	each	DT
cord-022313-2675sjlf	694	22	of	of	IN
cord-022313-2675sjlf	694	23	the	the	DT
cord-022313-2675sjlf	694	24	enzymes	enzyme	NNS
cord-022313-2675sjlf	694	25	to	to	TO
cord-022313-2675sjlf	694	26	be	be	VB
cord-022313-2675sjlf	694	27	inhibited	inhibit	VBN
cord-022313-2675sjlf	694	28	and	and	CC
cord-022313-2675sjlf	694	29	then	then	RB
cord-022313-2675sjlf	694	30	design	design	NN
cord-022313-2675sjlf	694	31	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	694	32	based	base	VBN
cord-022313-2675sjlf	694	33	on	on	IN
cord-022313-2675sjlf	694	34	this	this	DT
cord-022313-2675sjlf	694	35	knowledge	knowledge	NN
cord-022313-2675sjlf	694	36	.	.	.
cord-022313-2675sjlf	695	1	While	while	IN
cord-022313-2675sjlf	695	2	this	this	DT
cord-022313-2675sjlf	695	3	approach	approach	NN
cord-022313-2675sjlf	695	4	is	be	VBZ
cord-022313-2675sjlf	695	5	certainly	certainly	RB
cord-022313-2675sjlf	695	6	possible	possible	JJ
cord-022313-2675sjlf	695	7	,	,	,
cord-022313-2675sjlf	695	8	it	-PRON-	PRP
cord-022313-2675sjlf	695	9	is	be	VBZ
cord-022313-2675sjlf	695	10	not	not	RB
cord-022313-2675sjlf	695	11	likely	likely	JJ
cord-022313-2675sjlf	695	12	to	to	TO
cord-022313-2675sjlf	695	13	be	be	VB
cord-022313-2675sjlf	695	14	feasible	feasible	JJ
cord-022313-2675sjlf	695	15	in	in	IN
cord-022313-2675sjlf	695	16	the	the	DT
cord-022313-2675sjlf	695	17	immediate	immediate	JJ
cord-022313-2675sjlf	695	18	future	future	NN
cord-022313-2675sjlf	695	19	.	.	.
cord-022313-2675sjlf	696	1	Most	Most	JJS
cord-022313-2675sjlf	696	2	of	of	IN
cord-022313-2675sjlf	696	3	the	the	DT
cord-022313-2675sjlf	696	4	enzymes	enzyme	NNS
cord-022313-2675sjlf	696	5	involved	involve	VBN
cord-022313-2675sjlf	696	6	in	in	IN
cord-022313-2675sjlf	696	7	the	the	DT
cord-022313-2675sjlf	696	8	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	696	9	of	of	IN
cord-022313-2675sjlf	696	10	N	n	NN
cord-022313-2675sjlf	696	11	-	-	HYPH
cord-022313-2675sjlf	696	12	linked	link	VBN
cord-022313-2675sjlf	696	13	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	696	14	or	or	CC
cord-022313-2675sjlf	696	15	membrane	membrane	NN
cord-022313-2675sjlf	696	16	anchors	anchor	NNS
cord-022313-2675sjlf	696	17	appear	appear	VBP
cord-022313-2675sjlf	696	18	to	to	TO
cord-022313-2675sjlf	696	19	be	be	VB
cord-022313-2675sjlf	696	20	present	present	JJ
cord-022313-2675sjlf	696	21	in	in	IN
cord-022313-2675sjlf	696	22	cells	cell	NNS
cord-022313-2675sjlf	696	23	in	in	IN
cord-022313-2675sjlf	696	24	relatively	relatively	RB
cord-022313-2675sjlf	696	25	low	low	JJ
cord-022313-2675sjlf	696	26	abundance	abundance	NN
cord-022313-2675sjlf	696	27	,	,	,
cord-022313-2675sjlf	696	28	and	and	CC
cord-022313-2675sjlf	696	29	therefore	therefore	RB
cord-022313-2675sjlf	696	30	even	even	RB
cord-022313-2675sjlf	696	31	the	the	DT
cord-022313-2675sjlf	696	32	purification	purification	NN
cord-022313-2675sjlf	696	33	of	of	IN
cord-022313-2675sjlf	696	34	these	these	DT
cord-022313-2675sjlf	696	35	enzymes	enzyme	NNS
cord-022313-2675sjlf	696	36	to	to	IN
cord-022313-2675sjlf	696	37	homogeneity	homogeneity	NN
cord-022313-2675sjlf	696	38	is	be	VBZ
cord-022313-2675sjlf	696	39	difficult	difficult	JJ
cord-022313-2675sjlf	696	40	.	.	.
cord-022313-2675sjlf	697	1	Actually	actually	RB
cord-022313-2675sjlf	697	2	,	,	,
cord-022313-2675sjlf	697	3	several	several	JJ
cord-022313-2675sjlf	697	4	of	of	IN
cord-022313-2675sjlf	697	5	these	these	DT
cord-022313-2675sjlf	697	6	proteins	protein	NNS
cord-022313-2675sjlf	697	7	have	have	VBP
cord-022313-2675sjlf	697	8	now	now	RB
cord-022313-2675sjlf	697	9	been	be	VBN
cord-022313-2675sjlf	697	10	purified	purify	VBN
cord-022313-2675sjlf	697	11	to	to	IN
cord-022313-2675sjlf	697	12	homogeneity	homogeneity	NN
cord-022313-2675sjlf	697	13	,	,	,
cord-022313-2675sjlf	697	14	and	and	CC
cord-022313-2675sjlf	697	15	perhaps	perhaps	RB
cord-022313-2675sjlf	697	16	with	with	IN
cord-022313-2675sjlf	697	17	modern	modern	JJ
cord-022313-2675sjlf	697	18	approaches	approach	NNS
cord-022313-2675sjlf	697	19	of	of	IN
cord-022313-2675sjlf	697	20	molecular	molecular	JJ
cord-022313-2675sjlf	697	21	biol	biol	NNP
cord-022313-2675sjlf	697	22	ogy	ogy	NNP
cord-022313-2675sjlf	697	23	,	,	,
cord-022313-2675sjlf	697	24	they	-PRON-	PRP
cord-022313-2675sjlf	697	25	can	can	MD
cord-022313-2675sjlf	697	26	be	be	VB
cord-022313-2675sjlf	697	27	cloned	clone	VBN
cord-022313-2675sjlf	697	28	and	and	CC
cord-022313-2675sjlf	697	29	produced	produce	VBN
cord-022313-2675sjlf	697	30	in	in	IN
cord-022313-2675sjlf	697	31	sufficient	sufficient	JJ
cord-022313-2675sjlf	697	32	amounts	amount	NNS
cord-022313-2675sjlf	697	33	for	for	IN
cord-022313-2675sjlf	697	34	crystalli	crystalli	NNP
cord-022313-2675sjlf	697	35	zation	zation	NNP
cord-022313-2675sjlf	697	36	.	.	.
cord-022313-2675sjlf	698	1	A	a	DT
cord-022313-2675sjlf	698	2	second	second	JJ
cord-022313-2675sjlf	698	3	approach	approach	NN
cord-022313-2675sjlf	698	4	is	be	VBZ
cord-022313-2675sjlf	698	5	to	to	TO
cord-022313-2675sjlf	698	6	design	design	VB
cord-022313-2675sjlf	698	7	new	new	JJ
cord-022313-2675sjlf	698	8	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	698	9	based	base	VBN
cord-022313-2675sjlf	698	10	on	on	IN
cord-022313-2675sjlf	698	11	the	the	DT
cord-022313-2675sjlf	698	12	structures	structure	NNS
cord-022313-2675sjlf	698	13	of	of	IN
cord-022313-2675sjlf	698	14	already	already	RB
cord-022313-2675sjlf	698	15	known	know	VBN
cord-022313-2675sjlf	698	16	prototypes	prototype	NNS
cord-022313-2675sjlf	698	17	.	.	.
cord-022313-2675sjlf	699	1	In	in	IN
cord-022313-2675sjlf	699	2	this	this	DT
cord-022313-2675sjlf	699	3	regard	regard	NN
cord-022313-2675sjlf	699	4	,	,	,
cord-022313-2675sjlf	699	5	various	various	JJ
cord-022313-2675sjlf	699	6	laboratories	laboratory	NNS
cord-022313-2675sjlf	699	7	are	be	VBP
cord-022313-2675sjlf	699	8	currently	currently	RB
cord-022313-2675sjlf	699	9	conducting	conduct	VBG
cord-022313-2675sjlf	699	10	modeling	modeling	NN
cord-022313-2675sjlf	699	11	studies	study	NNS
cord-022313-2675sjlf	699	12	with	with	IN
cord-022313-2675sjlf	699	13	the	the	DT
cord-022313-2675sjlf	699	14	known	know	VBN
cord-022313-2675sjlf	699	15	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	699	16	to	to	TO
cord-022313-2675sjlf	699	17	provide	provide	VB
cord-022313-2675sjlf	699	18	the	the	DT
cord-022313-2675sjlf	699	19	basis	basis	NN
cord-022313-2675sjlf	699	20	for	for	IN
cord-022313-2675sjlf	699	21	developing	develop	VBG
cord-022313-2675sjlf	699	22	analogs	analog	NNS
cord-022313-2675sjlf	699	23	of	of	IN
cord-022313-2675sjlf	699	24	already	already	RB
cord-022313-2675sjlf	699	25	-	-	HYPH
cord-022313-2675sjlf	699	26	known	know	VBN
cord-022313-2675sjlf	699	27	compounds	compound	NNS
cord-022313-2675sjlf	699	28	.	.	.
cord-022313-2675sjlf	700	1	While	while	IN
cord-022313-2675sjlf	700	2	this	this	DT
cord-022313-2675sjlf	700	3	is	be	VBZ
cord-022313-2675sjlf	700	4	a	a	DT
cord-022313-2675sjlf	700	5	viable	viable	JJ
cord-022313-2675sjlf	700	6	and	and	CC
cord-022313-2675sjlf	700	7	logical	logical	JJ
cord-022313-2675sjlf	700	8	way	way	NN
cord-022313-2675sjlf	700	9	to	to	TO
cord-022313-2675sjlf	700	10	develop	develop	VB
cord-022313-2675sjlf	700	11	new	new	JJ
cord-022313-2675sjlf	700	12	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	700	13	,	,	,
cord-022313-2675sjlf	700	14	it	-PRON-	PRP
cord-022313-2675sjlf	700	15	does	do	VBZ
cord-022313-2675sjlf	700	16	have	have	VB
cord-022313-2675sjlf	700	17	one	one	CD
cord-022313-2675sjlf	700	18	major	major	JJ
cord-022313-2675sjlf	700	19	shortcoming	shortcoming	NN
cord-022313-2675sjlf	700	20	,	,	,
cord-022313-2675sjlf	700	21	which	which	WDT
cord-022313-2675sjlf	700	22	is	be	VBZ
cord-022313-2675sjlf	700	23	that	that	IN
cord-022313-2675sjlf	700	24	this	this	DT
cord-022313-2675sjlf	700	25	approach	approach	NN
cord-022313-2675sjlf	700	26	can	can	MD
cord-022313-2675sjlf	700	27	not	not	RB
cord-022313-2675sjlf	700	28	provide	provide	VB
cord-022313-2675sjlf	700	29	completely	completely	RB
cord-022313-2675sjlf	700	30	new	new	JJ
cord-022313-2675sjlf	700	31	and	and	CC
cord-022313-2675sjlf	700	32	novel	novel	JJ
cord-022313-2675sjlf	700	33	structures	structure	NNS
cord-022313-2675sjlf	700	34	that	that	WDT
cord-022313-2675sjlf	700	35	could	could	MD
cord-022313-2675sjlf	700	36	lead	lead	VB
cord-022313-2675sjlf	700	37	to	to	IN
cord-022313-2675sjlf	700	38	even	even	RB
cord-022313-2675sjlf	700	39	better	well	JJR
cord-022313-2675sjlf	700	40	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	700	41	than	than	IN
cord-022313-2675sjlf	700	42	those	those	DT
cord-022313-2675sjlf	700	43	that	that	WDT
cord-022313-2675sjlf	700	44	we	-PRON-	PRP
cord-022313-2675sjlf	700	45	already	already	RB
cord-022313-2675sjlf	700	46	have	have	VBP
cord-022313-2675sjlf	700	47	available	available	JJ
cord-022313-2675sjlf	700	48	.	.	.
cord-022313-2675sjlf	701	1	In	in	IN
cord-022313-2675sjlf	701	2	that	that	DT
cord-022313-2675sjlf	701	3	respect	respect	NN
cord-022313-2675sjlf	701	4	,	,	,
cord-022313-2675sjlf	701	5	perhaps	perhaps	RB
cord-022313-2675sjlf	701	6	we	-PRON-	PRP
cord-022313-2675sjlf	701	7	need	need	VBP
cord-022313-2675sjlf	701	8	to	to	TO
cord-022313-2675sjlf	701	9	take	take	VB
cord-022313-2675sjlf	701	10	a	a	DT
cord-022313-2675sjlf	701	11	lesson	lesson	NN
cord-022313-2675sjlf	701	12	from	from	IN
cord-022313-2675sjlf	701	13	nature	nature	NN
cord-022313-2675sjlf	701	14	since	since	IN
cord-022313-2675sjlf	701	15	evolution	evolution	NN
cord-022313-2675sjlf	701	16	has	have	VBZ
cord-022313-2675sjlf	701	17	had	have	VBN
cord-022313-2675sjlf	701	18	millions	million	NNS
cord-022313-2675sjlf	701	19	of	of	IN
cord-022313-2675sjlf	701	20	years	year	NNS
cord-022313-2675sjlf	701	21	to	to	TO
cord-022313-2675sjlf	701	22	develop	develop	VB
cord-022313-2675sjlf	701	23	all	all	DT
cord-022313-2675sjlf	701	24	sorts	sort	NNS
cord-022313-2675sjlf	701	25	of	of	IN
cord-022313-2675sjlf	701	26	unusual	unusual	JJ
cord-022313-2675sjlf	701	27	chemical	chemical	NN
cord-022313-2675sjlf	701	28	structures	structure	NNS
cord-022313-2675sjlf	701	29	.	.	.
cord-022313-2675sjlf	702	1	It	-PRON-	PRP
cord-022313-2675sjlf	702	2	is	be	VBZ
cord-022313-2675sjlf	702	3	unlikely	unlikely	JJ
cord-022313-2675sjlf	702	4	that	that	IN
cord-022313-2675sjlf	702	5	penicillin	penicillin	NN
cord-022313-2675sjlf	702	6	,	,	,
cord-022313-2675sjlf	702	7	streptomycin	streptomycin	NNS
cord-022313-2675sjlf	702	8	,	,	,
cord-022313-2675sjlf	702	9	or	or	CC
cord-022313-2675sjlf	702	10	bleomycin	bleomycin	NN
cord-022313-2675sjlf	702	11	,	,	,
cord-022313-2675sjlf	702	12	to	to	TO
cord-022313-2675sjlf	702	13	name	name	VB
cord-022313-2675sjlf	702	14	a	a	DT
cord-022313-2675sjlf	702	15	few	few	JJ
cord-022313-2675sjlf	702	16	,	,	,
cord-022313-2675sjlf	702	17	could	could	MD
cord-022313-2675sjlf	702	18	have	have	VB
cord-022313-2675sjlf	702	19	been	be	VBN
cord-022313-2675sjlf	702	20	chemically	chemically	RB
cord-022313-2675sjlf	702	21	synthesized	synthesize	VBN
cord-022313-2675sjlf	702	22	de	de	IN
cord-022313-2675sjlf	702	23	novo	novo	NN
cord-022313-2675sjlf	702	24	without	without	IN
cord-022313-2675sjlf	702	25	first	first	RB
cord-022313-2675sjlf	702	26	hav	hav	NNP
cord-022313-2675sjlf	702	27	ing	e	VBG
cord-022313-2675sjlf	702	28	been	be	VBN
cord-022313-2675sjlf	702	29	isolated	isolate	VBN
cord-022313-2675sjlf	702	30	and	and	CC
cord-022313-2675sjlf	702	31	characterized	characterize	VBN
cord-022313-2675sjlf	702	32	from	from	IN
cord-022313-2675sjlf	702	33	natural	natural	JJ
cord-022313-2675sjlf	702	34	sources	source	NNS
cord-022313-2675sjlf	702	35	.	.	.
cord-022313-2675sjlf	703	1	Thus	thus	RB
cord-022313-2675sjlf	703	2	,	,	,
cord-022313-2675sjlf	703	3	the	the	DT
cord-022313-2675sjlf	703	4	third	third	JJ
cord-022313-2675sjlf	703	5	approach	approach	NN
cord-022313-2675sjlf	703	6	to	to	TO
cord-022313-2675sjlf	703	7	better	well	JJR
cord-022313-2675sjlf	703	8	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	703	9	that	that	WDT
cord-022313-2675sjlf	703	10	should	should	MD
cord-022313-2675sjlf	703	11	not	not	RB
cord-022313-2675sjlf	703	12	be	be	VB
cord-022313-2675sjlf	703	13	ignored	ignore	VBN
cord-022313-2675sjlf	703	14	is	be	VBZ
cord-022313-2675sjlf	703	15	to	to	TO
cord-022313-2675sjlf	703	16	look	look	VB
cord-022313-2675sjlf	703	17	for	for	IN
cord-022313-2675sjlf	703	18	new	new	JJ
cord-022313-2675sjlf	703	19	inhibitory	inhibitory	JJ
cord-022313-2675sjlf	703	20	compounds	compound	NNS
cord-022313-2675sjlf	703	21	from	from	IN
cord-022313-2675sjlf	703	22	natural	natural	JJ
cord-022313-2675sjlf	703	23	sources	source	NNS
cord-022313-2675sjlf	703	24	,	,	,
cord-022313-2675sjlf	703	25	because	because	IN
cord-022313-2675sjlf	703	26	this	this	DT
cord-022313-2675sjlf	703	27	seems	seem	VBZ
cord-022313-2675sjlf	703	28	like	like	IN
cord-022313-2675sjlf	703	29	the	the	DT
cord-022313-2675sjlf	703	30	most	most	RBS
cord-022313-2675sjlf	703	31	likely	likely	JJ
cord-022313-2675sjlf	703	32	way	way	NN
cord-022313-2675sjlf	703	33	to	to	TO
cord-022313-2675sjlf	703	34	find	find	VB
cord-022313-2675sjlf	703	35	new	new	JJ
cord-022313-2675sjlf	703	36	and	and	CC
cord-022313-2675sjlf	703	37	previously	previously	RB
cord-022313-2675sjlf	703	38	unknown	unknown	JJ
cord-022313-2675sjlf	703	39	structures	structure	NNS
cord-022313-2675sjlf	703	40	.	.	.
cord-022313-2675sjlf	704	1	Early	early	JJ
cord-022313-2675sjlf	704	2	events	event	NNS
cord-022313-2675sjlf	704	3	in	in	IN
cord-022313-2675sjlf	704	4	mammalian	mammalian	JJ
cord-022313-2675sjlf	704	5	fertilization	fertilization	NN
cord-022313-2675sjlf	705	1	The	the	DT
cord-022313-2675sjlf	705	2	biogenesis	biogenesis	NN
cord-022313-2675sjlf	705	3	of	of	IN
cord-022313-2675sjlf	705	4	lysosomes	lysosome	NNS
cord-022313-2675sjlf	705	5	Carbohydrate	Carbohydrate	NNP
cord-022313-2675sjlf	705	6	specific	specific	JJ
cord-022313-2675sjlf	705	7	receptors	receptor	NNS
cord-022313-2675sjlf	705	8	of	of	IN
cord-022313-2675sjlf	705	9	the	the	DT
cord-022313-2675sjlf	705	10	liver	liver	NN
cord-022313-2675sjlf	706	1	A	a	DT
cord-022313-2675sjlf	706	2	molecular	molecular	JJ
cord-022313-2675sjlf	706	3	model	model	NN
cord-022313-2675sjlf	706	4	for	for	IN
cord-022313-2675sjlf	706	5	cell	cell	NN
cord-022313-2675sjlf	706	6	interactions	interaction	NNS
cord-022313-2675sjlf	706	7	Lymphocyte	Lymphocyte	NNP
cord-022313-2675sjlf	706	8	homing	homing	NN
cord-022313-2675sjlf	706	9	:	:	:
cord-022313-2675sjlf	706	10	Progress	progress	NN
cord-022313-2675sjlf	706	11	and	and	CC
cord-022313-2675sjlf	706	12	prospects	prospect	NNS
cord-022313-2675sjlf	706	13	Carbohydrate	carbohydrate	JJ
cord-022313-2675sjlf	706	14	specificity	specificity	NN
cord-022313-2675sjlf	706	15	of	of	IN
cord-022313-2675sjlf	706	16	the	the	DT
cord-022313-2675sjlf	706	17	surface	surface	NN
cord-022313-2675sjlf	706	18	lectins	lectin	NNS
cord-022313-2675sjlf	706	19	of	of	IN
cord-022313-2675sjlf	706	20	E.	E.	NNP
cord-022313-2675sjlf	706	21	coli	coli	NNS
cord-022313-2675sjlf	706	22	,	,	,
cord-022313-2675sjlf	706	23	K.	K.	NNP
cord-022313-2675sjlf	706	24	pneumoniae	pneumoniae	NN
cord-022313-2675sjlf	706	25	,	,	,
cord-022313-2675sjlf	706	26	and	and	CC
cord-022313-2675sjlf	706	27	S.	S.	NNP
cord-022313-2675sjlf	706	28	typhimurium	typhimurium	NN
cord-022313-2675sjlf	706	29	Carbohydrates	carbohydrate	NNS
cord-022313-2675sjlf	706	30	as	as	IN
cord-022313-2675sjlf	706	31	antigenic	antigenic	JJ
cord-022313-2675sjlf	706	32	determinants	determinant	NNS
cord-022313-2675sjlf	706	33	of	of	IN
cord-022313-2675sjlf	706	34	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	706	35	Glycosylation	Glycosylation	NNP
cord-022313-2675sjlf	707	1	engineering	engineer	VBG
cord-022313-2675sjlf	707	2	Comparative	comparative	JJ
cord-022313-2675sjlf	707	3	aspects	aspect	NNS
cord-022313-2675sjlf	707	4	of	of	IN
cord-022313-2675sjlf	707	5	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	707	6	struc	struc	JJ
cord-022313-2675sjlf	707	7	ture	ture	NNP
cord-022313-2675sjlf	708	1	The	the	DT
cord-022313-2675sjlf	708	2	carbohydrates	carbohydrate	NNS
cord-022313-2675sjlf	708	3	of	of	IN
cord-022313-2675sjlf	708	4	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	708	5	Cell	cell	NN
cord-022313-2675sjlf	708	6	surface	surface	NN
cord-022313-2675sjlf	708	7	mucin	mucin	NN
cord-022313-2675sjlf	708	8	-	-	HYPH
cord-022313-2675sjlf	708	9	type	type	NN
cord-022313-2675sjlf	708	10	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	708	11	and	and	CC
cord-022313-2675sjlf	708	12	mucin	mucin	NN
cord-022313-2675sjlf	708	13	-	-	HYPH
cord-022313-2675sjlf	708	14	like	like	JJ
cord-022313-2675sjlf	708	15	domains	domain	NNS
cord-022313-2675sjlf	708	16	Aberrant	aberrant	JJ
cord-022313-2675sjlf	708	17	glycosylation	glycosylation	NN
cord-022313-2675sjlf	708	18	in	in	IN
cord-022313-2675sjlf	708	19	tumors	tumor	NNS
cord-022313-2675sjlf	708	20	and	and	CC
cord-022313-2675sjlf	709	1	tumor	tumor	NN
cord-022313-2675sjlf	709	2	-	-	HYPH
cord-022313-2675sjlf	709	3	associated	associate	VBN
cord-022313-2675sjlf	709	4	carbo	carbo	NN
cord-022313-2675sjlf	709	5	hydrate	hydrate	NN
cord-022313-2675sjlf	709	6	antigens	antigen	NNS
cord-022313-2675sjlf	709	7	Animal	Animal	NNP
cord-022313-2675sjlf	709	8	glycosphingolipids	glycosphingolipid	NNS
cord-022313-2675sjlf	709	9	as	as	IN
cord-022313-2675sjlf	709	10	membrane	membrane	NN
cord-022313-2675sjlf	709	11	attachment	attachment	NN
cord-022313-2675sjlf	709	12	sites	site	NNS
cord-022313-2675sjlf	709	13	for	for	IN
cord-022313-2675sjlf	709	14	bacteria	bacteria	NNS
cord-022313-2675sjlf	709	15	Glycolipid	Glycolipid	NNP
cord-022313-2675sjlf	709	16	anchoring	anchor	VBG
cord-022313-2675sjlf	709	17	of	of	IN
cord-022313-2675sjlf	709	18	plasma	plasma	NN
cord-022313-2675sjlf	709	19	membrane	membrane	NN
cord-022313-2675sjlf	709	20	proteins	protein	NNS
cord-022313-2675sjlf	709	21	Cell	Cell	NNP
cord-022313-2675sjlf	709	22	surface	surface	NN
cord-022313-2675sjlf	709	23	anchoring	anchoring	NN
cord-022313-2675sjlf	709	24	of	of	IN
cord-022313-2675sjlf	709	25	pro	pro	JJ
cord-022313-2675sjlf	709	26	teins	tein	NNS
cord-022313-2675sjlf	709	27	via	via	IN
cord-022313-2675sjlf	709	28	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NNP
cord-022313-2675sjlf	709	29	structures	structure	NNS
cord-022313-2675sjlf	710	1	Identifying	identify	VBG
cord-022313-2675sjlf	710	2	glycoconugate	glycoconugate	NNP
cord-022313-2675sjlf	710	3	binding	bind	VBG
cord-022313-2675sjlf	710	4	domains	domain	NNS
cord-022313-2675sjlf	711	1	:	:	:
cord-022313-2675sjlf	711	2	Building	build	VBG
cord-022313-2675sjlf	711	3	on	on	IN
cord-022313-2675sjlf	711	4	the	the	DT
cord-022313-2675sjlf	711	5	past	past	JJ
cord-022313-2675sjlf	711	6	Characteriza	Characteriza	NNP
cord-022313-2675sjlf	711	7	tion	tion	NN
cord-022313-2675sjlf	711	8	of	of	IN
cord-022313-2675sjlf	711	9	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	711	10	and	and	CC
cord-022313-2675sjlf	711	11	their	-PRON-	PRP$
cord-022313-2675sjlf	711	12	associated	associate	VBN
cord-022313-2675sjlf	711	13	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	711	14	through	through	IN
cord-022313-2675sjlf	711	15	the	the	DT
cord-022313-2675sjlf	711	16	use	use	NN
cord-022313-2675sjlf	711	17	of	of	IN
cord-022313-2675sjlf	711	18	endoglycosidases	endoglycosidase	NNS
cord-022313-2675sjlf	711	19	Endoglycosidases	Endoglycosidases	NNP
cord-022313-2675sjlf	711	20	from	from	IN
cord-022313-2675sjlf	711	21	Flavobacterium	Flavobacterium	NNP
cord-022313-2675sjlf	711	22	meningosepticum	meningosepticum	NN
cord-022313-2675sjlf	711	23	and	and	CC
cord-022313-2675sjlf	711	24	application	application	NN
cord-022313-2675sjlf	711	25	to	to	IN
cord-022313-2675sjlf	711	26	biological	biological	JJ
cord-022313-2675sjlf	711	27	problems	problem	NNS
cord-022313-2675sjlf	712	1	Tunicamycins	tunicamycin	NNS
cord-022313-2675sjlf	713	1	Tunicamycin	Tunicamycin	NNP
cord-022313-2675sjlf	713	2	inhibition	inhibition	NN
cord-022313-2675sjlf	713	3	of	of	IN
cord-022313-2675sjlf	713	4	polyisoprenyl	polyisoprenyl	JJ
cord-022313-2675sjlf	713	5	Nacetylglucosaminyl	Nacetylglucosaminyl	NNP
cord-022313-2675sjlf	713	6	pyrophosphate	pyrophosphate	NN
cord-022313-2675sjlf	713	7	formation	formation	NN
cord-022313-2675sjlf	713	8	in	in	IN
cord-022313-2675sjlf	713	9	calf	calf	NN
cord-022313-2675sjlf	713	10	liver	liver	NN
cord-022313-2675sjlf	713	11	microsomes	microsome	NNS
cord-022313-2675sjlf	713	12	Biological	biological	JJ
cord-022313-2675sjlf	713	13	activities	activity	NNS
cord-022313-2675sjlf	713	14	of	of	IN
cord-022313-2675sjlf	713	15	isolated	isolate	VBN
cord-022313-2675sjlf	713	16	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	713	17	and	and	CC
cord-022313-2675sjlf	713	18	streptovirudin	streptovirudin	NN
cord-022313-2675sjlf	713	19	fractions	fraction	NNS
cord-022313-2675sjlf	713	20	Amino	amino	NN
cord-022313-2675sjlf	713	21	acid	acid	NN
cord-022313-2675sjlf	713	22	sequences	sequence	NNS
cord-022313-2675sjlf	713	23	in	in	IN
cord-022313-2675sjlf	713	24	the	the	DT
cord-022313-2675sjlf	713	25	domain	domain	NN
cord-022313-2675sjlf	713	26	and	and	CC
cord-022313-2675sjlf	713	27	not	not	RB
cord-022313-2675sjlf	713	28	glycosylation	glycosylation	NN
cord-022313-2675sjlf	713	29	are	be	VBP
cord-022313-2675sjlf	713	30	important	important	JJ
cord-022313-2675sjlf	713	31	in	in	IN
cord-022313-2675sjlf	713	32	HLA	HLA	NNP
cord-022313-2675sjlf	713	33	-	-	HYPH
cord-022313-2675sjlf	713	34	A2	A2	NNP
cord-022313-2675sjlf	713	35	/	/	SYM
cord-022313-2675sjlf	713	36	j8Z	j8Z	NNP
cord-022313-2675sjlf	713	37	-	-	HYPH
cord-022313-2675sjlf	713	38	microglobulin	microglobulin	NNP
cord-022313-2675sjlf	713	39	association	association	NN
cord-022313-2675sjlf	713	40	and	and	CC
cord-022313-2675sjlf	713	41	cell	cell	NN
cord-022313-2675sjlf	713	42	surface	surface	NN
cord-022313-2675sjlf	713	43	association	association	NN
cord-022313-2675sjlf	713	44	Glycosylation	Glycosylation	NNP
cord-022313-2675sjlf	713	45	of	of	IN
cord-022313-2675sjlf	713	46	human	human	JJ
cord-022313-2675sjlf	713	47	protein	protein	NN
cord-022313-2675sjlf	713	48	C	C	NNP
cord-022313-2675sjlf	713	49	affects	affect	VBZ
cord-022313-2675sjlf	713	50	its	-PRON-	PRP$
cord-022313-2675sjlf	713	51	secretion	secretion	NN
cord-022313-2675sjlf	713	52	,	,	,
cord-022313-2675sjlf	713	53	processing	processing	NN
cord-022313-2675sjlf	713	54	,	,	,
cord-022313-2675sjlf	713	55	functional	functional	JJ
cord-022313-2675sjlf	713	56	activities	activity	NNS
cord-022313-2675sjlf	713	57	and	and	CC
cord-022313-2675sjlf	713	58	activation	activation	NN
cord-022313-2675sjlf	713	59	by	by	IN
cord-022313-2675sjlf	713	60	thrombin	thrombin	NN
cord-022313-2675sjlf	713	61	Glycosylation	Glycosylation	NNP
cord-022313-2675sjlf	713	62	mutants	mutant	NNS
cord-022313-2675sjlf	713	63	of	of	IN
cord-022313-2675sjlf	713	64	animal	animal	NN
cord-022313-2675sjlf	713	65	cells	cell	NNS
cord-022313-2675sjlf	714	1	A	a	DT
cord-022313-2675sjlf	714	2	mutant	mutant	NN
cord-022313-2675sjlf	714	3	of	of	IN
cord-022313-2675sjlf	714	4	Chinese	chinese	JJ
cord-022313-2675sjlf	714	5	hamster	hamster	NN
cord-022313-2675sjlf	714	6	ovary	ovary	NN
cord-022313-2675sjlf	714	7	cells	cell	NNS
cord-022313-2675sjlf	714	8	with	with	IN
cord-022313-2675sjlf	714	9	altered	altered	JJ
cord-022313-2675sjlf	714	10	mannose-6-P	mannose-6-p	JJ
cord-022313-2675sjlf	714	11	receptor	receptor	NN
cord-022313-2675sjlf	714	12	activity	activity	NN
cord-022313-2675sjlf	714	13	is	be	VBZ
cord-022313-2675sjlf	714	14	unable	unable	JJ
cord-022313-2675sjlf	714	15	to	to	TO
cord-022313-2675sjlf	714	16	synthesize	synthesize	VB
cord-022313-2675sjlf	714	17	mannosylphosphoryl	mannosylphosphoryl	NNP
cord-022313-2675sjlf	714	18	-	-	JJ
cord-022313-2675sjlf	714	19	dolichol	dolichol	NNP
cord-022313-2675sjlf	714	20	Sugar	Sugar	NNP
cord-022313-2675sjlf	714	21	residues	residue	NNS
cord-022313-2675sjlf	714	22	on	on	IN
cord-022313-2675sjlf	714	23	proteins	protein	NNS
cord-022313-2675sjlf	714	24	Synthesis	Synthesis	NNP
cord-022313-2675sjlf	714	25	and	and	CC
cord-022313-2675sjlf	714	26	processing	processing	NN
cord-022313-2675sjlf	714	27	of	of	IN
cord-022313-2675sjlf	714	28	asparagine-1inked	asparagine-1inked	JJ
cord-022313-2675sjlf	714	29	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	714	30	Glycoprotein	Glycoprotein	NNP
cord-022313-2675sjlf	714	31	synthesis	synthesis	NN
cord-022313-2675sjlf	714	32	in	in	IN
cord-022313-2675sjlf	714	33	aorta	aorta	NN
cord-022313-2675sjlf	714	34	:	:	:
cord-022313-2675sjlf	714	35	Biosynthe	Biosynthe	NNP
cord-022313-2675sjlf	714	36	sis	sis	NN
cord-022313-2675sjlf	714	37	and	and	CC
cord-022313-2675sjlf	714	38	characterization	characterization	NN
cord-022313-2675sjlf	714	39	of	of	IN
cord-022313-2675sjlf	714	40	lipid	lipid	NN
cord-022313-2675sjlf	714	41	-	-	HYPH
cord-022313-2675sjlf	714	42	linked	link	VBN
cord-022313-2675sjlf	714	43	sugars	sugar	NNS
cord-022313-2675sjlf	714	44	and	and	CC
cord-022313-2675sjlf	714	45	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	715	1	The	the	DT
cord-022313-2675sjlf	715	2	role	role	NN
cord-022313-2675sjlf	715	3	of	of	IN
cord-022313-2675sjlf	715	4	lipid	lipid	NN
cord-022313-2675sjlf	715	5	-	-	HYPH
cord-022313-2675sjlf	715	6	linked	link	VBN
cord-022313-2675sjlf	715	7	saccharides	saccharide	NNS
cord-022313-2675sjlf	715	8	in	in	IN
cord-022313-2675sjlf	715	9	the	the	DT
cord-022313-2675sjlf	715	10	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	715	11	of	of	IN
cord-022313-2675sjlf	715	12	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	715	13	Purification	purification	NN
cord-022313-2675sjlf	715	14	and	and	CC
cord-022313-2675sjlf	715	15	properties	property	NNS
cord-022313-2675sjlf	715	16	of	of	IN
cord-022313-2675sjlf	715	17	UDP	udp	NN
cord-022313-2675sjlf	715	18	-	-	HYPH
cord-022313-2675sjlf	715	19	GlcNAc	glcnac	NN
cord-022313-2675sjlf	715	20	:	:	:
cord-022313-2675sjlf	716	1	dolichol	dolichol	NNP
cord-022313-2675sjlf	716	2	-	-	HYPH
cord-022313-2675sjlf	716	3	P	p	NN
cord-022313-2675sjlf	716	4	GlcNAc-1-P	glcnac-1-p	JJ
cord-022313-2675sjlf	716	5	-	-	HYPH
cord-022313-2675sjlf	716	6	transferase	transferase	NN
cord-022313-2675sjlf	716	7	N	N	NNP
cord-022313-2675sjlf	716	8	-	-	HYPH
cord-022313-2675sjlf	716	9	Acetylglucosamine	Acetylglucosamine	NNP
cord-022313-2675sjlf	716	10	-	-	HYPH
cord-022313-2675sjlf	716	11	l	l	NN
cord-022313-2675sjlf	716	12	-	-	HYPH
cord-022313-2675sjlf	716	13	P	p	NN
cord-022313-2675sjlf	716	14	trans	trans	NN
cord-022313-2675sjlf	716	15	ferase	ferase	NN
cord-022313-2675sjlf	716	16	from	from	IN
cord-022313-2675sjlf	716	17	hen	hen	NNP
cord-022313-2675sjlf	716	18	oviduct	oviduct	NN
cord-022313-2675sjlf	716	19	:	:	:
cord-022313-2675sjlf	716	20	Solubilization	solubilization	NN
cord-022313-2675sjlf	716	21	,	,	,
cord-022313-2675sjlf	716	22	characterization	characterization	NN
cord-022313-2675sjlf	716	23	and	and	CC
cord-022313-2675sjlf	716	24	inhibition	inhibition	NN
cord-022313-2675sjlf	716	25	by	by	IN
cord-022313-2675sjlf	716	26	tuni	tuni	NNP
cord-022313-2675sjlf	716	27	camycin	camycin	NNS
cord-022313-2675sjlf	716	28	Purification	Purification	NNP
cord-022313-2675sjlf	716	29	and	and	CC
cord-022313-2675sjlf	716	30	characterization	characterization	NN
cord-022313-2675sjlf	716	31	of	of	IN
cord-022313-2675sjlf	716	32	UDP	udp	NN
cord-022313-2675sjlf	716	33	-	-	HYPH
cord-022313-2675sjlf	716	34	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	716	35	:	:	:
cord-022313-2675sjlf	716	36	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	716	37	-	-	HYPH
cord-022313-2675sjlf	716	38	P	P	NNP
cord-022313-2675sjlf	716	39	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	716	40	-	-	HYPH
cord-022313-2675sjlf	716	41	l	l	NN
cord-022313-2675sjlf	716	42	-	-	HYPH
cord-022313-2675sjlf	716	43	P	p	NN
cord-022313-2675sjlf	716	44	transferase	transferase	NN
cord-022313-2675sjlf	716	45	involved	involve	VBN
cord-022313-2675sjlf	716	46	in	in	IN
cord-022313-2675sjlf	716	47	the	the	DT
cord-022313-2675sjlf	716	48	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	716	49	of	of	IN
cord-022313-2675sjlf	716	50	asparagine	asparagine	NN
cord-022313-2675sjlf	716	51	-	-	HYPH
cord-022313-2675sjlf	716	52	linked	link	VBN
cord-022313-2675sjlf	716	53	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	716	54	in	in	IN
cord-022313-2675sjlf	716	55	mammary	mammary	JJ
cord-022313-2675sjlf	716	56	gland	gland	NN
cord-022313-2675sjlf	716	57	Biosynthesis	Biosynthesis	NNP
cord-022313-2675sjlf	716	58	of	of	IN
cord-022313-2675sjlf	716	59	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	716	60	-	-	HYPH
cord-022313-2675sjlf	716	61	PP	PP	NNP
cord-022313-2675sjlf	716	62	-	-	HYPH
cord-022313-2675sjlf	716	63	dolichol	dolichol	NNP
cord-022313-2675sjlf	716	64	,	,	,
cord-022313-2675sjlf	716	65	the	the	DT
cord-022313-2675sjlf	716	66	committed	committed	JJ
cord-022313-2675sjlf	716	67	step	step	NN
cord-022313-2675sjlf	716	68	of	of	IN
cord-022313-2675sjlf	716	69	asparagine	asparagine	NN
cord-022313-2675sjlf	716	70	-	-	HYPH
cord-022313-2675sjlf	716	71	linked	link	VBN
cord-022313-2675sjlf	716	72	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	716	73	assembly	assembly	NN
cord-022313-2675sjlf	716	74	Purification	purification	NN
cord-022313-2675sjlf	716	75	and	and	CC
cord-022313-2675sjlf	716	76	properties	property	NNS
cord-022313-2675sjlf	716	77	of	of	IN
cord-022313-2675sjlf	716	78	the	the	DT
cord-022313-2675sjlf	716	79	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	716	80	transferase	transferase	NN
cord-022313-2675sjlf	716	81	that	that	WDT
cord-022313-2675sjlf	716	82	adds	add	VBZ
cord-022313-2675sjlf	716	83	the	the	DT
cord-022313-2675sjlf	716	84	second	second	JJ
cord-022313-2675sjlf	716	85	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	716	86	to	to	IN
cord-022313-2675sjlf	716	87	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	716	88	-	-	HYPH
cord-022313-2675sjlf	716	89	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	716	90	-	-	HYPH
cord-022313-2675sjlf	716	91	PP	PP	NNP
cord-022313-2675sjlf	716	92	-	-	HYPH
cord-022313-2675sjlf	716	93	dolichol	dolichol	NNP
cord-022313-2675sjlf	717	1	The	the	DT
cord-022313-2675sjlf	717	2	primary	primary	JJ
cord-022313-2675sjlf	717	3	glycosylation	glycosylation	NN
cord-022313-2675sjlf	717	4	defect	defect	NN
cord-022313-2675sjlf	717	5	in	in	IN
cord-022313-2675sjlf	717	6	class	class	NN
cord-022313-2675sjlf	718	1	Ε	Ε	NNP
cord-022313-2675sjlf	718	2	thy-1-negative	thy-1-negative	CD
cord-022313-2675sjlf	718	3	mutant	mutant	JJ
cord-022313-2675sjlf	718	4	mouse	mouse	NN
cord-022313-2675sjlf	718	5	lymphoma	lymphoma	NN
cord-022313-2675sjlf	718	6	cells	cell	NNS
cord-022313-2675sjlf	718	7	is	be	VBZ
cord-022313-2675sjlf	718	8	an	an	DT
cord-022313-2675sjlf	718	9	inability	inability	NN
cord-022313-2675sjlf	718	10	to	to	TO
cord-022313-2675sjlf	718	11	synthesise	synthesise	VB
cord-022313-2675sjlf	718	12	dolichol	dolichol	NN
cord-022313-2675sjlf	718	13	-	-	HYPH
cord-022313-2675sjlf	718	14	P	p	NN
cord-022313-2675sjlf	718	15	-	-	HYPH
cord-022313-2675sjlf	718	16	mannose	mannose	NN
cord-022313-2675sjlf	718	17	Amphomycin	Amphomycin	NNP
cord-022313-2675sjlf	718	18	inhibits	inhibit	VBZ
cord-022313-2675sjlf	718	19	mannose	mannose	NN
cord-022313-2675sjlf	718	20	incorporation	incorporation	NN
cord-022313-2675sjlf	718	21	into	into	IN
cord-022313-2675sjlf	718	22	lipid	lipid	NN
cord-022313-2675sjlf	718	23	-	-	HYPH
cord-022313-2675sjlf	718	24	linked	link	VBN
cord-022313-2675sjlf	718	25	saccharides	saccharide	NNS
cord-022313-2675sjlf	718	26	Amphomycin	Amphomycin	NNP
cord-022313-2675sjlf	718	27	inhibition	inhibition	NN
cord-022313-2675sjlf	718	28	of	of	IN
cord-022313-2675sjlf	718	29	mannose	mannose	NN
cord-022313-2675sjlf	718	30	and	and	CC
cord-022313-2675sjlf	718	31	GlcNAc	glcnac	NN
cord-022313-2675sjlf	718	32	incorporation	incorporation	NN
cord-022313-2675sjlf	718	33	into	into	IN
cord-022313-2675sjlf	718	34	lipid	lipid	NN
cord-022313-2675sjlf	718	35	-	-	HYPH
cord-022313-2675sjlf	718	36	linked	link	VBN
cord-022313-2675sjlf	718	37	saccharides	saccharide	NNS
cord-022313-2675sjlf	718	38	Purification	purification	NN
cord-022313-2675sjlf	718	39	and	and	CC
cord-022313-2675sjlf	718	40	properties	property	NNS
cord-022313-2675sjlf	718	41	of	of	IN
cord-022313-2675sjlf	718	42	β	β	NNP
cord-022313-2675sjlf	718	43	-	-	HYPH
cord-022313-2675sjlf	718	44	mannosyl	mannosyl	NNP
cord-022313-2675sjlf	718	45	transferase	transferase	NN
cord-022313-2675sjlf	718	46	that	that	WDT
cord-022313-2675sjlf	718	47	produces	produce	VBZ
cord-022313-2675sjlf	718	48	Man/3l,4GlcNAc£l	man/3l,4glcnac£l	RB
cord-022313-2675sjlf	718	49	,	,	,
cord-022313-2675sjlf	718	50	4GlcNAc	4glcnac	CD
cord-022313-2675sjlf	718	51	-	-	HYPH
cord-022313-2675sjlf	718	52	PP	pp	NN
cord-022313-2675sjlf	718	53	-	-	HYPH
cord-022313-2675sjlf	718	54	dolichol	dolichol	NNP
cord-022313-2675sjlf	719	1	The	the	DT
cord-022313-2675sjlf	719	2	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	719	3	of	of	IN
cord-022313-2675sjlf	719	4	oligosaccharidelipids	oligosaccharidelipid	NNS
cord-022313-2675sjlf	719	5	:	:	:
cord-022313-2675sjlf	719	6	Partial	partial	JJ
cord-022313-2675sjlf	719	7	purification	purification	NN
cord-022313-2675sjlf	719	8	and	and	CC
cord-022313-2675sjlf	719	9	characterization	characterization	NN
cord-022313-2675sjlf	719	10	of	of	IN
cord-022313-2675sjlf	719	11	mannosyltransferase	mannosyltransferase	NNP
cord-022313-2675sjlf	719	12	II	II	NNP
cord-022313-2675sjlf	720	1	The	the	DT
cord-022313-2675sjlf	720	2	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	720	3	of	of	IN
cord-022313-2675sjlf	720	4	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	720	5	lipids	lipid	NNS
cord-022313-2675sjlf	720	6	:	:	:
cord-022313-2675sjlf	720	7	Formation	formation	NN
cord-022313-2675sjlf	720	8	of	of	IN
cord-022313-2675sjlf	720	9	an	an	DT
cord-022313-2675sjlf	720	10	al,2-mannosyl	al,2-mannosyl	NNP
cord-022313-2675sjlf	720	11	-	-	HYPH
cord-022313-2675sjlf	720	12	mannose	mannose	NN
cord-022313-2675sjlf	720	13	linkage	linkage	NN
cord-022313-2675sjlf	720	14	Solubilization	Solubilization	NNP
cord-022313-2675sjlf	720	15	of	of	IN
cord-022313-2675sjlf	720	16	mannosyltransferase	mannosyltransferase	JJ
cord-022313-2675sjlf	720	17	activities	activity	NNS
cord-022313-2675sjlf	720	18	for	for	IN
cord-022313-2675sjlf	720	19	the	the	DT
cord-022313-2675sjlf	720	20	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	720	21	of	of	IN
cord-022313-2675sjlf	720	22	mammary	mammary	JJ
cord-022313-2675sjlf	720	23	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	720	24	Transfer	transfer	NN
cord-022313-2675sjlf	720	25	of	of	IN
cord-022313-2675sjlf	720	26	mannose	mannose	NN
cord-022313-2675sjlf	720	27	from	from	IN
cord-022313-2675sjlf	720	28	GDP	gdp	NN
cord-022313-2675sjlf	720	29	-	-	HYPH
cord-022313-2675sjlf	720	30	mannose	mannose	NN
cord-022313-2675sjlf	720	31	to	to	IN
cord-022313-2675sjlf	720	32	lipid	lipid	NN
cord-022313-2675sjlf	720	33	-	-	HYPH
cord-022313-2675sjlf	720	34	linked	link	VBN
cord-022313-2675sjlf	720	35	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	720	36	by	by	IN
cord-022313-2675sjlf	720	37	soluble	soluble	JJ
cord-022313-2675sjlf	720	38	mannosyltransferase	mannosyltransferase	NNP
cord-022313-2675sjlf	720	39	Assembly	Assembly	NNP
cord-022313-2675sjlf	720	40	of	of	IN
cord-022313-2675sjlf	720	41	asparagine	asparagine	NN
cord-022313-2675sjlf	720	42	-	-	HYPH
cord-022313-2675sjlf	720	43	linked	link	VBN
cord-022313-2675sjlf	720	44	oligosaccha	oligosaccha	NN
cord-022313-2675sjlf	720	45	rides	ride	VBZ
cord-022313-2675sjlf	720	46	Glucose	Glucose	NNP
cord-022313-2675sjlf	720	47	transfer	transfer	NN
cord-022313-2675sjlf	720	48	from	from	IN
cord-022313-2675sjlf	720	49	dolichol	dolichol	NNP
cord-022313-2675sjlf	720	50	monophosphate	monophosphate	NN
cord-022313-2675sjlf	720	51	glucose	glucose	NN
cord-022313-2675sjlf	720	52	:	:	:
cord-022313-2675sjlf	720	53	The	the	DT
cord-022313-2675sjlf	720	54	product	product	NN
cord-022313-2675sjlf	720	55	formed	form	VBN
cord-022313-2675sjlf	720	56	with	with	IN
cord-022313-2675sjlf	720	57	endogenous	endogenous	JJ
cord-022313-2675sjlf	720	58	microsomal	microsomal	NNP
cord-022313-2675sjlf	720	59	acceptor	acceptor	NN
cord-022313-2675sjlf	720	60	Purification	Purification	NNP
cord-022313-2675sjlf	720	61	and	and	CC
cord-022313-2675sjlf	720	62	characterization	characterization	NN
cord-022313-2675sjlf	720	63	of	of	IN
cord-022313-2675sjlf	720	64	dolichyl	dolichyl	NN
cord-022313-2675sjlf	720	65	-	-	HYPH
cord-022313-2675sjlf	720	66	P	p	NN
cord-022313-2675sjlf	720	67	-	-	HYPH
cord-022313-2675sjlf	720	68	mannose	mannose	NN
cord-022313-2675sjlf	720	69	:	:	:
cord-022313-2675sjlf	721	1	Man	man	NN
cord-022313-2675sjlf	721	2	5	5	CD
cord-022313-2675sjlf	722	1	(	(	-LRB-
cord-022313-2675sjlf	722	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	722	3	)	)	-RRB-
cord-022313-2675sjlf	722	4	2	2	CD
cord-022313-2675sjlf	723	1	-PP	-PP	NNP
cord-022313-2675sjlf	723	2	-	-	HYPH
cord-022313-2675sjlf	723	3	dolichol	dolichol	NNP
cord-022313-2675sjlf	723	4	mannosyl	mannosyl	NNP
cord-022313-2675sjlf	723	5	transferase	transferase	NNP
cord-022313-2675sjlf	723	6	Purification	Purification	NNP
cord-022313-2675sjlf	723	7	and	and	CC
cord-022313-2675sjlf	723	8	properties	property	NNS
cord-022313-2675sjlf	723	9	of	of	IN
cord-022313-2675sjlf	723	10	the	the	DT
cord-022313-2675sjlf	723	11	first	first	JJ
cord-022313-2675sjlf	723	12	glucosyltransferase	glucosyltransferase	NN
cord-022313-2675sjlf	723	13	that	that	WDT
cord-022313-2675sjlf	723	14	forms	form	VBZ
cord-022313-2675sjlf	724	1	Glc	Glc	NNP
cord-022313-2675sjlf	724	2	1	1	CD
cord-022313-2675sjlf	724	3	Man	Man	NNP
cord-022313-2675sjlf	724	4	9	9	CD
cord-022313-2675sjlf	724	5	(	(	-LRB-
cord-022313-2675sjlf	724	6	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	724	7	)	)	-RRB-
cord-022313-2675sjlf	724	8	2	2	CD
cord-022313-2675sjlf	724	9	-PP	-PP	NNS
cord-022313-2675sjlf	724	10	-	-	HYPH
cord-022313-2675sjlf	724	11	dolichol	dolichol	JJ
cord-022313-2675sjlf	724	12	from	from	IN
cord-022313-2675sjlf	724	13	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	724	14	-	-	HYPH
cord-022313-2675sjlf	724	15	P	p	NN
cord-022313-2675sjlf	724	16	-	-	HYPH
cord-022313-2675sjlf	724	17	glucose	glucose	NN
cord-022313-2675sjlf	724	18	and	and	CC
cord-022313-2675sjlf	724	19	Man	Man	NNP
cord-022313-2675sjlf	724	20	9	9	CD
cord-022313-2675sjlf	725	1	(	(	-LRB-
cord-022313-2675sjlf	725	2	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	725	3	)	)	-RRB-
cord-022313-2675sjlf	725	4	2	2	CD
cord-022313-2675sjlf	725	5	-PP	-PP	NNS
cord-022313-2675sjlf	725	6	-	-	HYPH
cord-022313-2675sjlf	725	7	dolichol	dolichol	NNP
cord-022313-2675sjlf	725	8	Comparative	comparative	JJ
cord-022313-2675sjlf	725	9	rates	rate	NNS
cord-022313-2675sjlf	725	10	of	of	IN
cord-022313-2675sjlf	725	11	transfer	transfer	NN
cord-022313-2675sjlf	725	12	of	of	IN
cord-022313-2675sjlf	725	13	lipid	lipid	NN
cord-022313-2675sjlf	725	14	-	-	HYPH
cord-022313-2675sjlf	725	15	linked	link	VBN
cord-022313-2675sjlf	725	16	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	725	17	to	to	IN
cord-022313-2675sjlf	725	18	endogenous	endogenous	JJ
cord-022313-2675sjlf	725	19	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	725	20	acceptors	acceptor	NNS
cord-022313-2675sjlf	725	21	in	in	IN
cord-022313-2675sjlf	725	22	vitro	vitro	FW
cord-022313-2675sjlf	725	23	Glycosylation	glycosylation	NN
cord-022313-2675sjlf	725	24	of	of	IN
cord-022313-2675sjlf	725	25	proteins	protein	NNS
cord-022313-2675sjlf	725	26	by	by	IN
cord-022313-2675sjlf	725	27	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	725	28	-	-	HYPH
cord-022313-2675sjlf	725	29	lipids	lipid	NNS
cord-022313-2675sjlf	725	30	:	:	:
cord-022313-2675sjlf	725	31	Studies	study	NNS
cord-022313-2675sjlf	725	32	on	on	IN
cord-022313-2675sjlf	725	33	a	a	DT
cord-022313-2675sjlf	725	34	thyroid	thyroid	NN
cord-022313-2675sjlf	725	35	enzyme	enzyme	NN
cord-022313-2675sjlf	725	36	involved	involve	VBN
cord-022313-2675sjlf	725	37	in	in	IN
cord-022313-2675sjlf	725	38	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	725	39	transfer	transfer	NN
cord-022313-2675sjlf	725	40	and	and	CC
cord-022313-2675sjlf	725	41	the	the	DT
cord-022313-2675sjlf	725	42	role	role	NN
cord-022313-2675sjlf	725	43	of	of	IN
cord-022313-2675sjlf	725	44	glucose	glucose	NN
cord-022313-2675sjlf	725	45	in	in	IN
cord-022313-2675sjlf	725	46	this	this	DT
cord-022313-2675sjlf	725	47	reaction	reaction	NN
cord-022313-2675sjlf	726	1	Synchronized	synchronize	VBN
cord-022313-2675sjlf	726	2	transmembrane	transmembrane	NN
cord-022313-2675sjlf	726	3	insertion	insertion	NN
cord-022313-2675sjlf	726	4	and	and	CC
cord-022313-2675sjlf	726	5	glycosylation	glycosylation	NN
cord-022313-2675sjlf	726	6	of	of	IN
cord-022313-2675sjlf	726	7	a	a	DT
cord-022313-2675sjlf	726	8	nascent	nascent	JJ
cord-022313-2675sjlf	726	9	membrane	membrane	NN
cord-022313-2675sjlf	726	10	protein	protein	NN
cord-022313-2675sjlf	726	11	Oligosaccharyl	Oligosaccharyl	NNP
cord-022313-2675sjlf	726	12	-	-	HYPH
cord-022313-2675sjlf	726	13	transferase	transferase	NN
cord-022313-2675sjlf	726	14	activity	activity	NN
cord-022313-2675sjlf	726	15	is	be	VBZ
cord-022313-2675sjlf	726	16	associated	associate	VBN
cord-022313-2675sjlf	726	17	with	with	IN
cord-022313-2675sjlf	726	18	a	a	DT
cord-022313-2675sjlf	726	19	protein	protein	NN
cord-022313-2675sjlf	726	20	complex	complex	NN
cord-022313-2675sjlf	726	21	composed	compose	VBN
cord-022313-2675sjlf	726	22	of	of	IN
cord-022313-2675sjlf	726	23	ribophorins	ribophorin	NNS
cord-022313-2675sjlf	726	24	I	I	NNP
cord-022313-2675sjlf	726	25	and	and	CC
cord-022313-2675sjlf	726	26	II	II	NNP
cord-022313-2675sjlf	726	27	and	and	CC
cord-022313-2675sjlf	726	28	a	a	DT
cord-022313-2675sjlf	726	29	48	48	CD
cord-022313-2675sjlf	726	30	kd	kd	NNP
cord-022313-2675sjlf	726	31	protein	protein	NN
cord-022313-2675sjlf	726	32	Characterization	characterization	NN
cord-022313-2675sjlf	726	33	of	of	IN
cord-022313-2675sjlf	726	34	a	a	DT
cord-022313-2675sjlf	726	35	glucosi	glucosi	NNP
cord-022313-2675sjlf	726	36	dase	dase	NN
cord-022313-2675sjlf	726	37	involved	involve	VBN
cord-022313-2675sjlf	726	38	in	in	IN
cord-022313-2675sjlf	726	39	an	an	DT
cord-022313-2675sjlf	726	40	initial	initial	JJ
cord-022313-2675sjlf	726	41	step	step	NN
cord-022313-2675sjlf	726	42	in	in	IN
cord-022313-2675sjlf	726	43	the	the	DT
cord-022313-2675sjlf	726	44	processing	processing	NN
cord-022313-2675sjlf	726	45	of	of	IN
cord-022313-2675sjlf	726	46	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	726	47	chains	chain	NNS
cord-022313-2675sjlf	726	48	Substrate	Substrate	NNP
cord-022313-2675sjlf	726	49	specificities	specificity	NNS
cord-022313-2675sjlf	726	50	of	of	IN
cord-022313-2675sjlf	726	51	rat	rat	NN
cord-022313-2675sjlf	726	52	liver	liver	NNP
cord-022313-2675sjlf	726	53	micro	micro	NNP
cord-022313-2675sjlf	726	54	somal	somal	NNP
cord-022313-2675sjlf	726	55	glucosidases	glucosidases	NNP
cord-022313-2675sjlf	726	56	which	which	WDT
cord-022313-2675sjlf	726	57	process	process	VBP
cord-022313-2675sjlf	726	58	glycoproteins	glycoprotein	VBZ
cord-022313-2675sjlf	726	59	Purification	purification	NN
cord-022313-2675sjlf	726	60	by	by	IN
cord-022313-2675sjlf	726	61	affinity	affinity	NN
cord-022313-2675sjlf	726	62	chromatog	chromatog	NNP
cord-022313-2675sjlf	726	63	raphy	raphy	NN
cord-022313-2675sjlf	726	64	of	of	IN
cord-022313-2675sjlf	726	65	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	726	66	I	I	NNP
cord-022313-2675sjlf	726	67	,	,	,
cord-022313-2675sjlf	726	68	an	an	DT
cord-022313-2675sjlf	726	69	ER	ER	NNP
cord-022313-2675sjlf	726	70	hydrolase	hydrolase	NN
cord-022313-2675sjlf	726	71	involved	involve	VBN
cord-022313-2675sjlf	726	72	in	in	IN
cord-022313-2675sjlf	726	73	processing	processing	NN
cord-022313-2675sjlf	726	74	of	of	IN
cord-022313-2675sjlf	726	75	asparagine	asparagine	NN
cord-022313-2675sjlf	726	76	-	-	HYPH
cord-022313-2675sjlf	726	77	linked	link	VBN
cord-022313-2675sjlf	726	78	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	726	79	Purification	purification	NN
cord-022313-2675sjlf	726	80	and	and	CC
cord-022313-2675sjlf	726	81	charac	charac	NN
cord-022313-2675sjlf	726	82	terization	terization	NN
cord-022313-2675sjlf	726	83	of	of	IN
cord-022313-2675sjlf	726	84	trimming	trim	VBG
cord-022313-2675sjlf	726	85	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	726	86	I	-PRON-	PRP
cord-022313-2675sjlf	726	87	from	from	IN
cord-022313-2675sjlf	726	88	pig	pig	NN
cord-022313-2675sjlf	726	89	liver	liver	NN
cord-022313-2675sjlf	726	90	Purification	Purification	NNP
cord-022313-2675sjlf	726	91	and	and	CC
cord-022313-2675sjlf	726	92	characteriza	characteriza	NN
cord-022313-2675sjlf	726	93	tion	tion	NN
cord-022313-2675sjlf	726	94	of	of	IN
cord-022313-2675sjlf	726	95	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	727	1	I	-PRON-	PRP
cord-022313-2675sjlf	727	2	involved	involve	VBD
cord-022313-2675sjlf	727	3	in	in	IN
cord-022313-2675sjlf	727	4	N	n	CD
cord-022313-2675sjlf	727	5	-	-	HYPH
cord-022313-2675sjlf	727	6	linked	link	VBN
cord-022313-2675sjlf	727	7	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	727	8	processing	processing	NN
cord-022313-2675sjlf	727	9	in	in	IN
cord-022313-2675sjlf	727	10	bovine	bovine	JJ
cord-022313-2675sjlf	727	11	mam	mam	NNP
cord-022313-2675sjlf	727	12	mary	mary	NNP
cord-022313-2675sjlf	727	13	gland	gland	NNP
cord-022313-2675sjlf	727	14	Purification	Purification	NNP
cord-022313-2675sjlf	727	15	and	and	CC
cord-022313-2675sjlf	727	16	properties	property	NNS
cord-022313-2675sjlf	727	17	of	of	IN
cord-022313-2675sjlf	727	18	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	727	19	I	-PRON-	PRP
cord-022313-2675sjlf	727	20	from	from	IN
cord-022313-2675sjlf	727	21	mung	mung	NN
cord-022313-2675sjlf	727	22	bean	bean	NN
cord-022313-2675sjlf	727	23	seedlings	seedling	NNS
cord-022313-2675sjlf	727	24	Purification	purification	NN
cord-022313-2675sjlf	727	25	and	and	CC
cord-022313-2675sjlf	727	26	characterization	characterization	NN
cord-022313-2675sjlf	727	27	of	of	IN
cord-022313-2675sjlf	727	28	trimming	trim	VBG
cord-022313-2675sjlf	727	29	glucosidase	glucosidase	NN
cord-022313-2675sjlf	727	30	I	-PRON-	PRP
cord-022313-2675sjlf	727	31	from	from	IN
cord-022313-2675sjlf	727	32	Saccharomyces	Saccharomyces	NNP
cord-022313-2675sjlf	727	33	cerevesiae	cerevesiae	VBZ
cord-022313-2675sjlf	727	34	Early	early	JJ
cord-022313-2675sjlf	727	35	steps	step	NNS
cord-022313-2675sjlf	727	36	in	in	IN
cord-022313-2675sjlf	727	37	processing	process	VBG
cord-022313-2675sjlf	727	38	yeast	yeast	NN
cord-022313-2675sjlf	727	39	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	727	40	Lectin	Lectin	NNP
cord-022313-2675sjlf	727	41	resistant	resistant	JJ
cord-022313-2675sjlf	727	42	CHO	CHO	NNP
cord-022313-2675sjlf	727	43	cell	cell	NN
cord-022313-2675sjlf	727	44	:	:	:
cord-022313-2675sjlf	727	45	Selection	selection	NN
cord-022313-2675sjlf	727	46	of	of	IN
cord-022313-2675sjlf	727	47	7	7	CD
cord-022313-2675sjlf	727	48	new	new	JJ
cord-022313-2675sjlf	727	49	mutants	mutant	NNS
cord-022313-2675sjlf	727	50	resistant	resistant	JJ
cord-022313-2675sjlf	727	51	to	to	IN
cord-022313-2675sjlf	727	52	ricin	ricin	NN
cord-022313-2675sjlf	727	53	Glycoprotein	Glycoprotein	NNP
cord-022313-2675sjlf	727	54	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	727	55	:	:	:
cord-022313-2675sjlf	727	56	Rat	Rat	NNP
cord-022313-2675sjlf	727	57	liver	liver	NN
cord-022313-2675sjlf	727	58	micro	micro	JJ
cord-022313-2675sjlf	727	59	somal	somal	FW
cord-022313-2675sjlf	727	60	glucosidases	glucosidases	NNP
cord-022313-2675sjlf	727	61	which	which	WDT
cord-022313-2675sjlf	727	62	process	process	NN
cord-022313-2675sjlf	727	63	oligosaccharides	oligosaccharide	VBZ
cord-022313-2675sjlf	727	64	Partial	partial	JJ
cord-022313-2675sjlf	727	65	purification	purification	NN
cord-022313-2675sjlf	727	66	and	and	CC
cord-022313-2675sjlf	727	67	characterization	characterization	NN
cord-022313-2675sjlf	727	68	of	of	IN
cord-022313-2675sjlf	727	69	the	the	DT
cord-022313-2675sjlf	727	70	glucosidase	glucosidase	NN
cord-022313-2675sjlf	727	71	involved	involve	VBN
cord-022313-2675sjlf	727	72	in	in	IN
cord-022313-2675sjlf	727	73	the	the	DT
cord-022313-2675sjlf	727	74	processing	processing	NN
cord-022313-2675sjlf	727	75	of	of	IN
cord-022313-2675sjlf	727	76	asparagine	asparagine	NN
cord-022313-2675sjlf	727	77	-	-	HYPH
cord-022313-2675sjlf	727	78	linked	link	VBN
cord-022313-2675sjlf	727	79	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	727	80	Inhibi	Inhibi	NNP
cord-022313-2675sjlf	727	81	tion	tion	NN
cord-022313-2675sjlf	727	82	of	of	IN
cord-022313-2675sjlf	727	83	N	n	NN
cord-022313-2675sjlf	727	84	-	-	HYPH
cord-022313-2675sjlf	727	85	linked	link	VBN
cord-022313-2675sjlf	727	86	complex	complex	JJ
cord-022313-2675sjlf	727	87	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	727	88	formation	formation	NN
cord-022313-2675sjlf	727	89	by	by	IN
cord-022313-2675sjlf	727	90	deoxynojirimycin	deoxynojirimycin	NNS
cord-022313-2675sjlf	727	91	,	,	,
cord-022313-2675sjlf	727	92	an	an	DT
cord-022313-2675sjlf	727	93	inhibi	inhibi	NNS
cord-022313-2675sjlf	727	94	tor	tor	NN
cord-022313-2675sjlf	727	95	of	of	IN
cord-022313-2675sjlf	727	96	processing	process	VBG
cord-022313-2675sjlf	727	97	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	727	98	Purification	Purification	NNP
cord-022313-2675sjlf	727	99	to	to	IN
cord-022313-2675sjlf	727	100	homogeneity	homogeneity	NN
cord-022313-2675sjlf	727	101	and	and	CC
cord-022313-2675sjlf	727	102	properties	property	NNS
cord-022313-2675sjlf	727	103	of	of	IN
cord-022313-2675sjlf	727	104	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	727	105	II	II	NNP
cord-022313-2675sjlf	727	106	from	from	IN
cord-022313-2675sjlf	727	107	mung	mung	NN
cord-022313-2675sjlf	727	108	bean	bean	NN
cord-022313-2675sjlf	727	109	seedlings	seedling	NNS
cord-022313-2675sjlf	727	110	and	and	CC
cord-022313-2675sjlf	727	111	suspension	suspension	NN
cord-022313-2675sjlf	727	112	cultured	cultured	JJ
cord-022313-2675sjlf	727	113	soybean	soybean	NN
cord-022313-2675sjlf	727	114	cells	cell	NNS
cord-022313-2675sjlf	727	115	Cell	cell	NN
cord-022313-2675sjlf	727	116	type	type	NN
cord-022313-2675sjlf	727	117	-	-	HYPH
cord-022313-2675sjlf	727	118	specific	specific	JJ
cord-022313-2675sjlf	727	119	post	post	JJ
cord-022313-2675sjlf	727	120	-	-	JJ
cord-022313-2675sjlf	727	121	Golgi	golgi	NN
cord-022313-2675sjlf	727	122	apparatus	apparatus	NN
cord-022313-2675sjlf	727	123	localization	localization	NN
cord-022313-2675sjlf	727	124	of	of	IN
cord-022313-2675sjlf	727	125	a	a	DT
cord-022313-2675sjlf	727	126	"	"	``
cord-022313-2675sjlf	727	127	resident	resident	NN
cord-022313-2675sjlf	727	128	"	"	''
cord-022313-2675sjlf	727	129	ER	ER	NNP
cord-022313-2675sjlf	727	130	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	727	131	,	,	,
cord-022313-2675sjlf	727	132	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	727	133	II	II	NNP
cord-022313-2675sjlf	727	134	Purification	Purification	NNP
cord-022313-2675sjlf	727	135	and	and	CC
cord-022313-2675sjlf	727	136	characterization	characterization	NN
cord-022313-2675sjlf	727	137	of	of	IN
cord-022313-2675sjlf	727	138	glucosi	glucosi	NNP
cord-022313-2675sjlf	727	139	dase	dase	NNP
cord-022313-2675sjlf	727	140	II	II	NNP
cord-022313-2675sjlf	727	141	,	,	,
cord-022313-2675sjlf	727	142	an	an	DT
cord-022313-2675sjlf	727	143	endoplasmic	endoplasmic	NN
cord-022313-2675sjlf	727	144	reticulum	reticulum	NN
cord-022313-2675sjlf	727	145	hydrolase	hydrolase	NN
cord-022313-2675sjlf	727	146	involved	involve	VBN
cord-022313-2675sjlf	727	147	in	in	IN
cord-022313-2675sjlf	727	148	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	727	149	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	727	150	Immunolocalization	immunolocalization	NN
cord-022313-2675sjlf	727	151	of	of	IN
cord-022313-2675sjlf	727	152	the	the	DT
cord-022313-2675sjlf	727	153	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	727	154	trimming	trimming	NN
cord-022313-2675sjlf	727	155	enzyme	enzyme	NN
cord-022313-2675sjlf	727	156	,	,	,
cord-022313-2675sjlf	727	157	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	728	1	II	II	NNP
cord-022313-2675sjlf	728	2	A	a	DT
cord-022313-2675sjlf	728	3	simple	simple	JJ
cord-022313-2675sjlf	728	4	and	and	CC
cord-022313-2675sjlf	728	5	reliable	reliable	JJ
cord-022313-2675sjlf	728	6	assay	assay	NN
cord-022313-2675sjlf	728	7	for	for	IN
cord-022313-2675sjlf	728	8	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	728	9	processing	processing	NN
cord-022313-2675sjlf	728	10	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	728	11	Relationship	relationship	NN
cord-022313-2675sjlf	728	12	between	between	IN
cord-022313-2675sjlf	728	13	different	different	JJ
cord-022313-2675sjlf	728	14	forms	form	NNS
cord-022313-2675sjlf	728	15	of	of	IN
cord-022313-2675sjlf	728	16	human	human	JJ
cord-022313-2675sjlf	728	17	α	α	NN
cord-022313-2675sjlf	728	18	-	-	HYPH
cord-022313-2675sjlf	728	19	mannosidase	mannosidase	NN
cord-022313-2675sjlf	728	20	Glycosidases	Glycosidases	NNP
cord-022313-2675sjlf	728	21	of	of	IN
cord-022313-2675sjlf	728	22	the	the	DT
cord-022313-2675sjlf	728	23	endo	endo	NNP
cord-022313-2675sjlf	728	24	plasmic	plasmic	JJ
cord-022313-2675sjlf	728	25	reticulum	reticulum	NN
cord-022313-2675sjlf	728	26	and	and	CC
cord-022313-2675sjlf	728	27	Golgi	Golgi	NNP
cord-022313-2675sjlf	728	28	apparatus	apparatus	NN
cord-022313-2675sjlf	728	29	Glycoprotein	Glycoprotein	NNP
cord-022313-2675sjlf	728	30	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	728	31	in	in	IN
cord-022313-2675sjlf	728	32	Saccharo	Saccharo	NNP
cord-022313-2675sjlf	728	33	myces	myce	VBZ
cord-022313-2675sjlf	728	34	cerevesiae	cerevesiae	NNP
cord-022313-2675sjlf	728	35	:	:	:
cord-022313-2675sjlf	729	1	Purification	purification	NN
cord-022313-2675sjlf	729	2	of	of	IN
cord-022313-2675sjlf	729	3	the	the	DT
cord-022313-2675sjlf	729	4	mannosidase	mannosidase	NN
cord-022313-2675sjlf	729	5	which	which	WDT
cord-022313-2675sjlf	729	6	removes	remove	VBZ
cord-022313-2675sjlf	729	7	one	one	CD
cord-022313-2675sjlf	729	8	specific	specific	JJ
cord-022313-2675sjlf	729	9	man	man	NN
cord-022313-2675sjlf	729	10	nose	nose	NN
cord-022313-2675sjlf	729	11	residue	residue	NN
cord-022313-2675sjlf	729	12	from	from	IN
cord-022313-2675sjlf	729	13	Man	Man	NNP
cord-022313-2675sjlf	729	14	9	9	CD
cord-022313-2675sjlf	729	15	(	(	-LRB-
cord-022313-2675sjlf	729	16	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	729	17	)	)	-RRB-
cord-022313-2675sjlf	729	18	2	2	CD
cord-022313-2675sjlf	729	19	Glycoprotein	Glycoprotein	NNP
cord-022313-2675sjlf	729	20	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	729	21	in	in	IN
cord-022313-2675sjlf	729	22	Saccharomyces	Saccharomyces	NNP
cord-022313-2675sjlf	729	23	cerevesiae	cerevesiae	NNP
cord-022313-2675sjlf	729	24	:	:	:
cord-022313-2675sjlf	729	25	Isolation	isolation	NN
cord-022313-2675sjlf	729	26	and	and	CC
cord-022313-2675sjlf	729	27	characterization	characterization	NN
cord-022313-2675sjlf	729	28	of	of	IN
cord-022313-2675sjlf	729	29	the	the	DT
cord-022313-2675sjlf	729	30	gene	gene	NN
cord-022313-2675sjlf	729	31	encoding	encode	VBG
cord-022313-2675sjlf	729	32	a	a	DT
cord-022313-2675sjlf	729	33	specific	specific	JJ
cord-022313-2675sjlf	729	34	processing	processing	NN
cord-022313-2675sjlf	729	35	α	α	NN
cord-022313-2675sjlf	729	36	-	-	HYPH
cord-022313-2675sjlf	729	37	mannosidase	mannosidase	NN
cord-022313-2675sjlf	729	38	Purification	purification	NN
cord-022313-2675sjlf	729	39	and	and	CC
cord-022313-2675sjlf	729	40	characterization	characterization	NN
cord-022313-2675sjlf	729	41	of	of	IN
cord-022313-2675sjlf	729	42	a	a	DT
cord-022313-2675sjlf	729	43	phospholipid	phospholipid	NN
cord-022313-2675sjlf	729	44	dependent	dependent	JJ
cord-022313-2675sjlf	729	45	α	α	NN
cord-022313-2675sjlf	729	46	-	-	HYPH
cord-022313-2675sjlf	729	47	mannosidase	mannosidase	NN
cord-022313-2675sjlf	729	48	from	from	IN
cord-022313-2675sjlf	729	49	rabbit	rabbit	NN
cord-022313-2675sjlf	729	50	liver	liver	NN
cord-022313-2675sjlf	729	51	Purification	purification	NN
cord-022313-2675sjlf	729	52	and	and	CC
cord-022313-2675sjlf	729	53	character	character	NN
cord-022313-2675sjlf	729	54	ization	ization	NN
cord-022313-2675sjlf	729	55	of	of	IN
cord-022313-2675sjlf	729	56	al,2-mannosidase	al,2-mannosidase	NNP
cord-022313-2675sjlf	729	57	involved	involve	VBN
cord-022313-2675sjlf	729	58	in	in	IN
cord-022313-2675sjlf	729	59	processing	process	VBG
cord-022313-2675sjlf	729	60	asparagine	asparagine	NN
cord-022313-2675sjlf	729	61	-	-	HYPH
cord-022313-2675sjlf	729	62	linked	link	VBN
cord-022313-2675sjlf	729	63	oligosaccha	oligosaccha	NN
cord-022313-2675sjlf	729	64	rides	ride	VBZ
cord-022313-2675sjlf	729	65	Purification	Purification	NNP
cord-022313-2675sjlf	729	66	and	and	CC
cord-022313-2675sjlf	729	67	characteriza	characteriza	NN
cord-022313-2675sjlf	729	68	tion	tion	NN
cord-022313-2675sjlf	729	69	of	of	IN
cord-022313-2675sjlf	729	70	a	a	DT
cord-022313-2675sjlf	729	71	neutral	neutral	JJ
cord-022313-2675sjlf	729	72	processing	processing	NN
cord-022313-2675sjlf	729	73	mannosidase	mannosidase	NN
cord-022313-2675sjlf	729	74	from	from	IN
cord-022313-2675sjlf	729	75	calf	calf	NN
cord-022313-2675sjlf	729	76	liver	liver	NN
cord-022313-2675sjlf	729	77	acting	act	VBG
cord-022313-2675sjlf	729	78	on	on	IN
cord-022313-2675sjlf	729	79	Man	Man	NNP
cord-022313-2675sjlf	729	80	9	9	CD
cord-022313-2675sjlf	729	81	(	(	-LRB-
cord-022313-2675sjlf	729	82	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	729	83	)	)	-RRB-
cord-022313-2675sjlf	729	84	2	2	CD
cord-022313-2675sjlf	730	1	-oligosaccharides	-oligosaccharide	NNS
cord-022313-2675sjlf	731	1	Characterization	characterization	NN
cord-022313-2675sjlf	731	2	of	of	IN
cord-022313-2675sjlf	731	3	trimming	trim	VBG
cord-022313-2675sjlf	731	4	Man	Man	NNP
cord-022313-2675sjlf	731	5	9	9	CD
cord-022313-2675sjlf	731	6	-mannosidase	-mannosidase	:
cord-022313-2675sjlf	731	7	from	from	IN
cord-022313-2675sjlf	731	8	pig	pig	NN
cord-022313-2675sjlf	731	9	liver	liver	NN
cord-022313-2675sjlf	731	10	Oligosaccharide	Oligosaccharide	NNP
cord-022313-2675sjlf	731	11	trimming	trim	VBG
cord-022313-2675sjlf	731	12	Man	Man	NNP
cord-022313-2675sjlf	731	13	9	9	CD
cord-022313-2675sjlf	731	14	-mannosidase	-mannosidase	NFP
cord-022313-2675sjlf	732	1	is	be	VBZ
cord-022313-2675sjlf	732	2	a	a	DT
cord-022313-2675sjlf	732	3	resident	resident	JJ
cord-022313-2675sjlf	732	4	ER	ER	NNP
cord-022313-2675sjlf	732	5	protein	protein	NN
cord-022313-2675sjlf	732	6	and	and	CC
cord-022313-2675sjlf	732	7	exhibits	exhibit	VBZ
cord-022313-2675sjlf	732	8	a	a	DT
cord-022313-2675sjlf	732	9	more	more	RBR
cord-022313-2675sjlf	732	10	re	re	JJ
cord-022313-2675sjlf	732	11	stricted	stricted	JJ
cord-022313-2675sjlf	732	12	local	local	JJ
cord-022313-2675sjlf	732	13	distribution	distribution	NN
cord-022313-2675sjlf	732	14	than	than	IN
cord-022313-2675sjlf	732	15	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	732	16	II	II	NNP
cord-022313-2675sjlf	732	17	Purification	Purification	NNP
cord-022313-2675sjlf	732	18	and	and	CC
cord-022313-2675sjlf	732	19	characterization	characterization	NN
cord-022313-2675sjlf	732	20	of	of	IN
cord-022313-2675sjlf	732	21	rat	rat	NN
cord-022313-2675sjlf	732	22	liver	liver	NN
cord-022313-2675sjlf	732	23	Golgi	Golgi	NNP
cord-022313-2675sjlf	732	24	«	«	''
cord-022313-2675sjlf	733	1	-mannosidase	-mannosidase	:
cord-022313-2675sjlf	734	1	capable	capable	JJ
cord-022313-2675sjlf	734	2	of	of	IN
cord-022313-2675sjlf	734	3	processing	process	VBG
cord-022313-2675sjlf	734	4	asparagine	asparagine	NN
cord-022313-2675sjlf	734	5	linked	link	VBN
cord-022313-2675sjlf	734	6	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	734	7	a	a	DT
cord-022313-2675sjlf	734	8	-	-	HYPH
cord-022313-2675sjlf	734	9	D	D	NNP
cord-022313-2675sjlf	734	10	-	-	HYPH
cord-022313-2675sjlf	734	11	Mannosidases	Mannosidases	NNPS
cord-022313-2675sjlf	734	12	of	of	IN
cord-022313-2675sjlf	734	13	rat	rat	NN
cord-022313-2675sjlf	734	14	liver	liver	NN
cord-022313-2675sjlf	734	15	Golgi	Golgi	NNP
cord-022313-2675sjlf	734	16	membranes	membrane	NNS
cord-022313-2675sjlf	735	1	The	the	DT
cord-022313-2675sjlf	735	2	purification	purification	NN
cord-022313-2675sjlf	735	3	and	and	CC
cord-022313-2675sjlf	735	4	characterization	characterization	NN
cord-022313-2675sjlf	735	5	of	of	IN
cord-022313-2675sjlf	735	6	mannosidase	mannosidase	NN
cord-022313-2675sjlf	735	7	IA	IA	NNP
cord-022313-2675sjlf	735	8	from	from	IN
cord-022313-2675sjlf	735	9	rat	rat	NN
cord-022313-2675sjlf	735	10	liver	liver	NN
cord-022313-2675sjlf	735	11	Golgi	Golgi	NNP
cord-022313-2675sjlf	735	12	membranes	membrane	NNS
cord-022313-2675sjlf	735	13	Purification	purification	NN
cord-022313-2675sjlf	735	14	and	and	CC
cord-022313-2675sjlf	735	15	characterization	characterization	NN
cord-022313-2675sjlf	735	16	of	of	IN
cord-022313-2675sjlf	735	17	a	a	DT
cord-022313-2675sjlf	735	18	rabbit	rabbit	NN
cord-022313-2675sjlf	735	19	liver	liver	NN
cord-022313-2675sjlf	735	20	«	«	NNP
cord-022313-2675sjlf	735	21	1,3	1,3	CD
cord-022313-2675sjlf	735	22	mannoside	mannoside	NN
cord-022313-2675sjlf	735	23	/32	/32	NNP
cord-022313-2675sjlf	735	24	-	-	HYPH
cord-022313-2675sjlf	735	25	7V	7v	CD
cord-022313-2675sjlf	735	26	-	-	HYPH
cord-022313-2675sjlf	735	27	acetyl	acetyl	NN
cord-022313-2675sjlf	735	28	-	-	HYPH
cord-022313-2675sjlf	735	29	glucosaminyltransferase	glucosaminyltransferase	NNP
cord-022313-2675sjlf	735	30	Control	Control	NNP
cord-022313-2675sjlf	735	31	of	of	IN
cord-022313-2675sjlf	735	32	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	735	33	synthesis	synthesis	NN
cord-022313-2675sjlf	735	34	:	:	:
cord-022313-2675sjlf	735	35	Purifica	Purifica	NNP
cord-022313-2675sjlf	735	36	tion	tion	NN
cord-022313-2675sjlf	735	37	of	of	IN
cord-022313-2675sjlf	735	38	UDP	UDP	NNP
cord-022313-2675sjlf	735	39	-	-	HYPH
cord-022313-2675sjlf	735	40	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	735	41	α	α	NN
cord-022313-2675sjlf	735	42	-	-	HYPH
cord-022313-2675sjlf	735	43	D	d	NN
cord-022313-2675sjlf	735	44	-	-	HYPH
cord-022313-2675sjlf	735	45	mannoside	mannoside	NN
cord-022313-2675sjlf	735	46	/31,2-GlcNAc	/31,2-GlcNAc	.
cord-022313-2675sjlf	735	47	transferase	transferase	NN
cord-022313-2675sjlf	735	48	II	II	NNP
cord-022313-2675sjlf	735	49	from	from	IN
cord-022313-2675sjlf	735	50	rat	rat	NN
cord-022313-2675sjlf	735	51	liver	liver	NN
cord-022313-2675sjlf	735	52	Molecular	molecular	JJ
cord-022313-2675sjlf	735	53	cloning	cloning	NN
cord-022313-2675sjlf	735	54	and	and	CC
cord-022313-2675sjlf	735	55	expression	expression	NN
cord-022313-2675sjlf	735	56	of	of	IN
cord-022313-2675sjlf	735	57	cDNA	cdna	NN
cord-022313-2675sjlf	735	58	encoding	encode	VBG
cord-022313-2675sjlf	735	59	the	the	DT
cord-022313-2675sjlf	735	60	enzyme	enzyme	NN
cord-022313-2675sjlf	735	61	that	that	WDT
cord-022313-2675sjlf	735	62	controls	control	VBZ
cord-022313-2675sjlf	735	63	conversion	conversion	NN
cord-022313-2675sjlf	735	64	of	of	IN
cord-022313-2675sjlf	735	65	high	high	JJ
cord-022313-2675sjlf	735	66	-	-	HYPH
cord-022313-2675sjlf	735	67	mannose	mannose	NN
cord-022313-2675sjlf	735	68	to	to	IN
cord-022313-2675sjlf	735	69	hybrid	hybrid	VB
cord-022313-2675sjlf	735	70	and	and	CC
cord-022313-2675sjlf	735	71	complex	complex	JJ
cord-022313-2675sjlf	735	72	N	n	CD
cord-022313-2675sjlf	735	73	-	-	HYPH
cord-022313-2675sjlf	735	74	glycans	glycan	NNS
cord-022313-2675sjlf	735	75	:	:	:
cord-022313-2675sjlf	735	76	UDP	udp	NN
cord-022313-2675sjlf	735	77	-	-	HYPH
cord-022313-2675sjlf	735	78	iV	iV	NNP
cord-022313-2675sjlf	735	79	-	-	HYPH
cord-022313-2675sjlf	735	80	acetylglucosamine	acetylglucosamine	NN
cord-022313-2675sjlf	735	81	:	:	:
cord-022313-2675sjlf	735	82	α-3-D	α-3-d	ADD
cord-022313-2675sjlf	735	83	-	-	HYPH
cord-022313-2675sjlf	735	84	mannoside	mannoside	NNP
cord-022313-2675sjlf	736	1	β	β	NNP
cord-022313-2675sjlf	736	2	-	-	HYPH
cord-022313-2675sjlf	736	3	l	l	NNP
cord-022313-2675sjlf	736	4	2-iV	2-iv	CD
cord-022313-2675sjlf	736	5	-	-	HYPH
cord-022313-2675sjlf	736	6	acetylglucosaminyltransferase	acetylglucosaminyltransferase	NNP
cord-022313-2675sjlf	737	1	I	-PRON-	PRP
cord-022313-2675sjlf	738	1	A	a	DT
cord-022313-2675sjlf	738	2	new	new	JJ
cord-022313-2675sjlf	738	3	α	α	NN
cord-022313-2675sjlf	738	4	-	-	HYPH
cord-022313-2675sjlf	738	5	D	d	NN
cord-022313-2675sjlf	738	6	-	-	HYPH
cord-022313-2675sjlf	738	7	mannosidase	mannosidase	NN
cord-022313-2675sjlf	738	8	occurring	occurring	NN
cord-022313-2675sjlf	738	9	in	in	IN
cord-022313-2675sjlf	738	10	Golgi	Golgi	NNP
cord-022313-2675sjlf	738	11	membranes	membrane	NNS
cord-022313-2675sjlf	738	12	Biosynthesis	Biosynthesis	NNP
cord-022313-2675sjlf	738	13	and	and	CC
cord-022313-2675sjlf	738	14	modification	modification	NN
cord-022313-2675sjlf	738	15	of	of	IN
cord-022313-2675sjlf	738	16	Golgi	Golgi	NNP
cord-022313-2675sjlf	738	17	mannosidase	mannosidase	NN
cord-022313-2675sjlf	738	18	II	II	NNP
cord-022313-2675sjlf	738	19	in	in	IN
cord-022313-2675sjlf	738	20	Hela	Hela	NNP
cord-022313-2675sjlf	738	21	and	and	CC
cord-022313-2675sjlf	738	22	3T3	3t3	CD
cord-022313-2675sjlf	738	23	Cells	Cells	NNP
cord-022313-2675sjlf	738	24	Purification	purification	NN
cord-022313-2675sjlf	738	25	and	and	CC
cord-022313-2675sjlf	738	26	character	character	NN
cord-022313-2675sjlf	738	27	ization	ization	NN
cord-022313-2675sjlf	738	28	of	of	IN
cord-022313-2675sjlf	738	29	α	α	NN
cord-022313-2675sjlf	738	30	-	-	HYPH
cord-022313-2675sjlf	738	31	D	D	NNP
cord-022313-2675sjlf	738	32	-	-	HYPH
cord-022313-2675sjlf	738	33	mannosidase	mannosidase	NN
cord-022313-2675sjlf	738	34	from	from	IN
cord-022313-2675sjlf	738	35	rat	rat	NN
cord-022313-2675sjlf	738	36	liver	liver	NN
cord-022313-2675sjlf	738	37	Golgi	Golgi	NNP
cord-022313-2675sjlf	738	38	mambranes	mambranes	NNP
cord-022313-2675sjlf	738	39	Purification	Purification	NNP
cord-022313-2675sjlf	738	40	to	to	IN
cord-022313-2675sjlf	738	41	homogeneity	homogeneity	NN
cord-022313-2675sjlf	738	42	and	and	CC
cord-022313-2675sjlf	738	43	properties	property	NNS
cord-022313-2675sjlf	738	44	of	of	IN
cord-022313-2675sjlf	738	45	mannosidase	mannosidase	NN
cord-022313-2675sjlf	738	46	II	II	NNP
cord-022313-2675sjlf	738	47	from	from	IN
cord-022313-2675sjlf	738	48	mung	mung	NN
cord-022313-2675sjlf	738	49	bean	bean	NN
cord-022313-2675sjlf	738	50	seedlings	seedling	NNS
cord-022313-2675sjlf	738	51	Isolation	isolation	NN
cord-022313-2675sjlf	738	52	,	,	,
cord-022313-2675sjlf	738	53	characterization	characterization	NN
cord-022313-2675sjlf	738	54	and	and	CC
cord-022313-2675sjlf	738	55	expression	expression	NN
cord-022313-2675sjlf	738	56	of	of	IN
cord-022313-2675sjlf	738	57	cDNA	cdna	NN
cord-022313-2675sjlf	738	58	encoding	encoding	NN
cord-022313-2675sjlf	738	59	murine	murine	JJ
cord-022313-2675sjlf	738	60	α	α	NNP
cord-022313-2675sjlf	738	61	-	-	HYPH
cord-022313-2675sjlf	738	62	mannosidase	mannosidase	NN
cord-022313-2675sjlf	738	63	II	II	NNP
cord-022313-2675sjlf	738	64	,	,	,
cord-022313-2675sjlf	738	65	a	a	DT
cord-022313-2675sjlf	738	66	Golgi	Golgi	NNP
cord-022313-2675sjlf	738	67	enzyme	enzyme	NN
cord-022313-2675sjlf	738	68	that	that	WDT
cord-022313-2675sjlf	738	69	controls	control	VBZ
cord-022313-2675sjlf	738	70	conver	conver	NNP
cord-022313-2675sjlf	738	71	sion	sion	NNP
cord-022313-2675sjlf	738	72	of	of	IN
cord-022313-2675sjlf	738	73	high	high	JJ
cord-022313-2675sjlf	738	74	-	-	HYPH
cord-022313-2675sjlf	738	75	mannose	mannose	NN
cord-022313-2675sjlf	738	76	to	to	IN
cord-022313-2675sjlf	738	77	complex	complex	JJ
cord-022313-2675sjlf	738	78	N	n	CD
cord-022313-2675sjlf	738	79	-	-	HYPH
cord-022313-2675sjlf	738	80	glycans	glycan	NNS
cord-022313-2675sjlf	738	81	Evidence	evidence	NN
cord-022313-2675sjlf	738	82	for	for	IN
cord-022313-2675sjlf	738	83	a	a	DT
cord-022313-2675sjlf	738	84	non	non	JJ
cord-022313-2675sjlf	738	85	-	-	JJ
cord-022313-2675sjlf	738	86	lysosomal	lysosomal	JJ
cord-022313-2675sjlf	738	87	α	α	NN
cord-022313-2675sjlf	738	88	-	-	HYPH
cord-022313-2675sjlf	738	89	mannosi	mannosi	JJ
cord-022313-2675sjlf	738	90	dase	dase	NNP
cord-022313-2675sjlf	738	91	in	in	IN
cord-022313-2675sjlf	738	92	rat	rat	NN
cord-022313-2675sjlf	738	93	liver	liver	NN
cord-022313-2675sjlf	738	94	homogenates	homogenate	VBZ
cord-022313-2675sjlf	738	95	Characterization	characterization	NN
cord-022313-2675sjlf	738	96	of	of	IN
cord-022313-2675sjlf	738	97	a	a	DT
cord-022313-2675sjlf	738	98	novel	novel	NN
cord-022313-2675sjlf	738	99	a	a	DT
cord-022313-2675sjlf	738	100	-	-	HYPH
cord-022313-2675sjlf	738	101	D	d	NN
cord-022313-2675sjlf	738	102	-	-	HYPH
cord-022313-2675sjlf	738	103	mannosidase	mannosidase	NN
cord-022313-2675sjlf	738	104	from	from	IN
cord-022313-2675sjlf	738	105	rat	rat	NN
cord-022313-2675sjlf	738	106	brain	brain	NN
cord-022313-2675sjlf	738	107	microsomes	microsomes	NNP
cord-022313-2675sjlf	739	1	Novel	novel	NN
cord-022313-2675sjlf	739	2	α	α	NNP
cord-022313-2675sjlf	739	3	-	-	HYPH
cord-022313-2675sjlf	739	4	Όmannosidase	Όmannosidase	NNP
cord-022313-2675sjlf	739	5	of	of	IN
cord-022313-2675sjlf	739	6	rat	rat	NN
cord-022313-2675sjlf	739	7	sperm	sperm	NN
cord-022313-2675sjlf	739	8	plasma	plasma	NN
cord-022313-2675sjlf	739	9	membranes	membrane	NNS
cord-022313-2675sjlf	739	10	:	:	:
cord-022313-2675sjlf	739	11	Characterization	characterization	NN
cord-022313-2675sjlf	739	12	and	and	CC
cord-022313-2675sjlf	739	13	potential	potential	JJ
cord-022313-2675sjlf	739	14	role	role	NN
cord-022313-2675sjlf	739	15	in	in	IN
cord-022313-2675sjlf	739	16	sperm	sperm	NN
cord-022313-2675sjlf	739	17	-	-	HYPH
cord-022313-2675sjlf	739	18	egg	egg	NN
cord-022313-2675sjlf	739	19	interactions	interaction	NNS
cord-022313-2675sjlf	739	20	Characterization	characterization	NN
cord-022313-2675sjlf	739	21	of	of	IN
cord-022313-2675sjlf	739	22	a	a	DT
cord-022313-2675sjlf	739	23	mannosidase	mannosidase	NN
cord-022313-2675sjlf	739	24	acting	act	VBG
cord-022313-2675sjlf	739	25	on	on	IN
cord-022313-2675sjlf	739	26	al,3	al,3	NNP
cord-022313-2675sjlf	739	27	and	and	CC
cord-022313-2675sjlf	739	28	al,6-linked	al,6-linked	JJ
cord-022313-2675sjlf	739	29	mannose	mannose	NN
cord-022313-2675sjlf	739	30	residues	residue	NNS
cord-022313-2675sjlf	739	31	of	of	IN
cord-022313-2675sjlf	739	32	oligomannosidic	oligomannosidic	JJ
cord-022313-2675sjlf	739	33	intermediates	intermediate	NNS
cord-022313-2675sjlf	739	34	of	of	IN
cord-022313-2675sjlf	739	35	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	739	36	processing	process	VBG
cord-022313-2675sjlf	739	37	Golgi	Golgi	NNP
cord-022313-2675sjlf	739	38	endo	endo	NN
cord-022313-2675sjlf	739	39	-	-	HYPH
cord-022313-2675sjlf	739	40	a	a	FW
cord-022313-2675sjlf	739	41	-	-	HYPH
cord-022313-2675sjlf	739	42	D	d	NN
cord-022313-2675sjlf	739	43	-	-	HYPH
cord-022313-2675sjlf	739	44	mannosidase	mannosidase	NN
cord-022313-2675sjlf	739	45	from	from	IN
cord-022313-2675sjlf	739	46	rat	rat	NN
cord-022313-2675sjlf	739	47	liver	liver	NN
cord-022313-2675sjlf	739	48	,	,	,
cord-022313-2675sjlf	739	49	a	a	DT
cord-022313-2675sjlf	739	50	novel	novel	JJ
cord-022313-2675sjlf	739	51	N	n	NN
cord-022313-2675sjlf	739	52	-	-	HYPH
cord-022313-2675sjlf	739	53	linked	link	VBN
cord-022313-2675sjlf	739	54	carbohydrate	carbohydrate	NN
cord-022313-2675sjlf	739	55	unit	unit	NN
cord-022313-2675sjlf	739	56	processing	processing	NN
cord-022313-2675sjlf	739	57	enzyme	enzyme	NN
cord-022313-2675sjlf	739	58	The	the	DT
cord-022313-2675sjlf	739	59	soluble	soluble	JJ
cord-022313-2675sjlf	739	60	form	form	NN
cord-022313-2675sjlf	739	61	of	of	IN
cord-022313-2675sjlf	739	62	rat	rat	NN
cord-022313-2675sjlf	739	63	liver	liver	NN
cord-022313-2675sjlf	739	64	a	a	DT
cord-022313-2675sjlf	739	65	-	-	HYPH
cord-022313-2675sjlf	739	66	mannosidase	mannosidase	NN
cord-022313-2675sjlf	739	67	is	be	VBZ
cord-022313-2675sjlf	739	68	immunologically	immunologically	RB
cord-022313-2675sjlf	739	69	related	relate	VBN
cord-022313-2675sjlf	739	70	to	to	IN
cord-022313-2675sjlf	739	71	the	the	DT
cord-022313-2675sjlf	739	72	ER	ER	NNP
cord-022313-2675sjlf	739	73	membrane	membrane	NN
cord-022313-2675sjlf	739	74	a	a	DT
cord-022313-2675sjlf	739	75	-	-	HYPH
cord-022313-2675sjlf	739	76	mannosidaase	mannosidaase	NN
cord-022313-2675sjlf	739	77	Glycosyltransferases	Glycosyltransferases	NNP
cord-022313-2675sjlf	739	78	and	and	CC
cord-022313-2675sjlf	739	79	their	-PRON-	PRP$
cord-022313-2675sjlf	739	80	use	use	NN
cord-022313-2675sjlf	739	81	in	in	IN
cord-022313-2675sjlf	739	82	assessing	assess	VBG
cord-022313-2675sjlf	739	83	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	739	84	structure	structure	NN
cord-022313-2675sjlf	739	85	and	and	CC
cord-022313-2675sjlf	739	86	struc	struc	JJ
cord-022313-2675sjlf	739	87	ture	ture	NN
cord-022313-2675sjlf	739	88	-	-	HYPH
cord-022313-2675sjlf	739	89	function	function	NN
cord-022313-2675sjlf	739	90	relationships	relationship	NNS
cord-022313-2675sjlf	739	91	Structure	structure	NN
cord-022313-2675sjlf	739	92	,	,	,
cord-022313-2675sjlf	739	93	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	739	94	and	and	CC
cord-022313-2675sjlf	739	95	function	function	NN
cord-022313-2675sjlf	739	96	of	of	IN
cord-022313-2675sjlf	739	97	glycosylphosphatidylinositols	glycosylphosphatidylinositols	NNP
cord-022313-2675sjlf	739	98	Candidate	Candidate	NNP
cord-022313-2675sjlf	739	99	glycophospholipid	glycophospholipid	NNP
cord-022313-2675sjlf	739	100	precussion	precussion	NN
cord-022313-2675sjlf	739	101	for	for	IN
cord-022313-2675sjlf	739	102	GPI	GPI	NNP
cord-022313-2675sjlf	739	103	membrane	membrane	NN
cord-022313-2675sjlf	739	104	anchor	anchor	NN
cord-022313-2675sjlf	739	105	of	of	IN
cord-022313-2675sjlf	739	106	Trypanosoma	Trypanosoma	NNP
cord-022313-2675sjlf	739	107	brucei	brucei	NNP
cord-022313-2675sjlf	739	108	variant	variant	NN
cord-022313-2675sjlf	739	109	surface	surface	NN
cord-022313-2675sjlf	739	110	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	739	111	Derivation	derivation	NN
cord-022313-2675sjlf	739	112	and	and	CC
cord-022313-2675sjlf	739	113	characterization	characterization	NN
cord-022313-2675sjlf	739	114	of	of	IN
cord-022313-2675sjlf	739	115	GPI	GPI	NNP
cord-022313-2675sjlf	739	116	anchor	anchor	NN
cord-022313-2675sjlf	739	117	-	-	HYPH
cord-022313-2675sjlf	739	118	defective	defective	JJ
cord-022313-2675sjlf	739	119	human	human	JJ
cord-022313-2675sjlf	739	120	K562	k562	CD
cord-022313-2675sjlf	739	121	cell	cell	NN
cord-022313-2675sjlf	739	122	clones	clone	NNS
cord-022313-2675sjlf	739	123	Biosynthesis	Biosynthesis	NNP
cord-022313-2675sjlf	739	124	of	of	IN
cord-022313-2675sjlf	739	125	the	the	DT
cord-022313-2675sjlf	739	126	GPI	GPI	NNP
cord-022313-2675sjlf	739	127	membrane	membrane	NN
cord-022313-2675sjlf	739	128	anchor	anchor	NN
cord-022313-2675sjlf	739	129	of	of	IN
cord-022313-2675sjlf	739	130	the	the	DT
cord-022313-2675sjlf	739	131	trypanosome	trypanosome	NNP
cord-022313-2675sjlf	739	132	variant	variant	NN
cord-022313-2675sjlf	739	133	surface	surface	NN
cord-022313-2675sjlf	739	134	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	739	135	Identification	identification	NN
cord-022313-2675sjlf	739	136	of	of	IN
cord-022313-2675sjlf	739	137	a	a	DT
cord-022313-2675sjlf	739	138	missing	missing	JJ
cord-022313-2675sjlf	739	139	link	link	NN
cord-022313-2675sjlf	739	140	in	in	IN
cord-022313-2675sjlf	739	141	GPI	GPI	NNP
cord-022313-2675sjlf	739	142	anchor	anchor	NN
cord-022313-2675sjlf	739	143	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	739	144	in	in	IN
cord-022313-2675sjlf	739	145	mammalian	mammalian	JJ
cord-022313-2675sjlf	739	146	cells	cell	NNS
cord-022313-2675sjlf	740	1	An	an	DT
cord-022313-2675sjlf	740	2	internally	internally	RB
cord-022313-2675sjlf	740	3	positioned	position	VBN
cord-022313-2675sjlf	740	4	signal	signal	NN
cord-022313-2675sjlf	740	5	can	can	MD
cord-022313-2675sjlf	740	6	direct	direct	JJ
cord-022313-2675sjlf	740	7	attachment	attachment	NN
cord-022313-2675sjlf	740	8	of	of	IN
cord-022313-2675sjlf	740	9	a	a	DT
cord-022313-2675sjlf	740	10	GPI	GPI	NNP
cord-022313-2675sjlf	740	11	membrane	membrane	NN
cord-022313-2675sjlf	740	12	anchor	anchor	NN
cord-022313-2675sjlf	740	13	Tunicamycin	Tunicamycin	NNP
cord-022313-2675sjlf	740	14	,	,	,
cord-022313-2675sjlf	740	15	a	a	DT
cord-022313-2675sjlf	740	16	new	new	JJ
cord-022313-2675sjlf	740	17	antibiotic	antibiotic	NN
cord-022313-2675sjlf	740	18	,	,	,
cord-022313-2675sjlf	740	19	I.	I.	NNP
cord-022313-2675sjlf	740	20	Isolation	isolation	NN
cord-022313-2675sjlf	740	21	and	and	CC
cord-022313-2675sjlf	740	22	characterization	characterization	NN
cord-022313-2675sjlf	740	23	of	of	IN
cord-022313-2675sjlf	740	24	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	741	1	The	the	DT
cord-022313-2675sjlf	741	2	structure	structure	NN
cord-022313-2675sjlf	741	3	of	of	IN
cord-022313-2675sjlf	741	4	tunicaminyl	tunicaminyl	NNP
cord-022313-2675sjlf	741	5	uracil	uracil	NNP
cord-022313-2675sjlf	741	6	,	,	,
cord-022313-2675sjlf	741	7	a	a	DT
cord-022313-2675sjlf	741	8	degradation	degradation	NN
cord-022313-2675sjlf	741	9	product	product	NN
cord-022313-2675sjlf	741	10	of	of	IN
cord-022313-2675sjlf	741	11	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	741	12	Separation	separation	NN
cord-022313-2675sjlf	741	13	of	of	IN
cord-022313-2675sjlf	741	14	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	741	15	homologues	homologue	NNS
cord-022313-2675sjlf	741	16	by	by	IN
cord-022313-2675sjlf	741	17	reversed	reverse	VBN
cord-022313-2675sjlf	741	18	high	high	JJ
cord-022313-2675sjlf	741	19	performance	performance	NN
cord-022313-2675sjlf	741	20	liquid	liquid	NN
cord-022313-2675sjlf	741	21	chromatography	chromatography	NN
cord-022313-2675sjlf	741	22	Mechanism	mechanism	NN
cord-022313-2675sjlf	741	23	of	of	IN
cord-022313-2675sjlf	741	24	action	action	NN
cord-022313-2675sjlf	741	25	of	of	IN
cord-022313-2675sjlf	741	26	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	741	27	on	on	IN
cord-022313-2675sjlf	741	28	the	the	DT
cord-022313-2675sjlf	741	29	UDP	UDP	NNP
cord-022313-2675sjlf	741	30	-	-	HYPH
cord-022313-2675sjlf	741	31	GlcNAc	glcnac	NN
cord-022313-2675sjlf	741	32	:	:	:
cord-022313-2675sjlf	742	1	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	742	2	-	-	HYPH
cord-022313-2675sjlf	742	3	P	P	NNP
cord-022313-2675sjlf	742	4	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	742	5	-	-	HYPH
cord-022313-2675sjlf	742	6	l	l	NN
cord-022313-2675sjlf	742	7	-	-	HYPH
cord-022313-2675sjlf	742	8	P	p	NN
cord-022313-2675sjlf	742	9	transferase	transferase	NN
cord-022313-2675sjlf	743	1	Tunicamycin	Tunicamycin	NNP
cord-022313-2675sjlf	743	2	inhibits	inhibit	VBZ
cord-022313-2675sjlf	743	3	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	743	4	lipid	lipid	NN
cord-022313-2675sjlf	743	5	formation	formation	NN
cord-022313-2675sjlf	743	6	in	in	IN
cord-022313-2675sjlf	743	7	plants	plant	NNS
cord-022313-2675sjlf	743	8	Evidence	evidence	NN
cord-022313-2675sjlf	743	9	for	for	IN
cord-022313-2675sjlf	743	10	the	the	DT
cord-022313-2675sjlf	743	11	participation	participation	NN
cord-022313-2675sjlf	743	12	of	of	IN
cord-022313-2675sjlf	743	13	saccharide	saccharide	NN
cord-022313-2675sjlf	743	14	-	-	HYPH
cord-022313-2675sjlf	743	15	lipids	lipid	NNS
cord-022313-2675sjlf	743	16	in	in	IN
cord-022313-2675sjlf	743	17	the	the	DT
cord-022313-2675sjlf	743	18	synthesis	synthesis	NN
cord-022313-2675sjlf	743	19	of	of	IN
cord-022313-2675sjlf	743	20	the	the	DT
cord-022313-2675sjlf	743	21	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	743	22	chain	chain	NN
cord-022313-2675sjlf	743	23	of	of	IN
cord-022313-2675sjlf	743	24	ovalbumin	ovalbumin	NNP
cord-022313-2675sjlf	743	25	Inhibition	Inhibition	NNP
cord-022313-2675sjlf	743	26	of	of	IN
cord-022313-2675sjlf	743	27	glycoconjugate	glycoconjugate	NN
cord-022313-2675sjlf	743	28	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	743	29	by	by	IN
cord-022313-2675sjlf	743	30	tunicamycin	tunicamycin	NNP
cord-022313-2675sjlf	743	31	Tunicamycin	Tunicamycin	NNP
cord-022313-2675sjlf	743	32	,	,	,
cord-022313-2675sjlf	743	33	an	an	DT
cord-022313-2675sjlf	743	34	inhibitor	inhibitor	NN
cord-022313-2675sjlf	743	35	of	of	IN
cord-022313-2675sjlf	743	36	Bacillus	Bacillus	NNP
cord-022313-2675sjlf	743	37	peptidoglycan	peptidoglycan	NN
cord-022313-2675sjlf	743	38	synthesis	synthesis	NN
cord-022313-2675sjlf	743	39	,	,	,
cord-022313-2675sjlf	743	40	a	a	DT
cord-022313-2675sjlf	743	41	new	new	JJ
cord-022313-2675sjlf	743	42	site	site	NN
cord-022313-2675sjlf	743	43	of	of	IN
cord-022313-2675sjlf	744	1	inhibition	inhibition	NN
cord-022313-2675sjlf	744	2	An	an	DT
cord-022313-2675sjlf	744	3	intermediate	intermediate	JJ
cord-022313-2675sjlf	744	4	in	in	IN
cord-022313-2675sjlf	744	5	teichoic	teichoic	NNP
cord-022313-2675sjlf	744	6	acid	acid	NNP
cord-022313-2675sjlf	744	7	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	744	8	Purification	purification	NN
cord-022313-2675sjlf	744	9	and	and	CC
cord-022313-2675sjlf	744	10	properties	property	NNS
cord-022313-2675sjlf	744	11	of	of	IN
cord-022313-2675sjlf	744	12	the	the	DT
cord-022313-2675sjlf	744	13	UDP	UDP	NNP
cord-022313-2675sjlf	744	14	-	-	HYPH
cord-022313-2675sjlf	744	15	GlcNAc	glcnac	NN
cord-022313-2675sjlf	744	16	:	:	:
cord-022313-2675sjlf	745	1	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	745	2	-	-	HYPH
cord-022313-2675sjlf	745	3	pyrophosphoryl	pyrophosphoryl	NNP
cord-022313-2675sjlf	745	4	-	-	HYPH
cord-022313-2675sjlf	745	5	GlcNAc	glcnac	JJ
cord-022313-2675sjlf	745	6	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	745	7	transferase	transferase	NN
cord-022313-2675sjlf	745	8	from	from	IN
cord-022313-2675sjlf	745	9	mung	mung	NN
cord-022313-2675sjlf	745	10	bean	bean	NN
cord-022313-2675sjlf	745	11	seedlings	seedling	NNS
cord-022313-2675sjlf	746	1	UDP	udp	NN
cord-022313-2675sjlf	746	2	-	-	HYPH
cord-022313-2675sjlf	746	3	Af	af	NN
cord-022313-2675sjlf	746	4	-	-	HYPH
cord-022313-2675sjlf	746	5	acetylglucosamine	acetylglucosamine	NN
cord-022313-2675sjlf	746	6	:	:	:
cord-022313-2675sjlf	746	7	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	746	8	N	n	CD
cord-022313-2675sjlf	746	9	-	-	HYPH
cord-022313-2675sjlf	746	10	acetylglucosamine-1	acetylglucosamine-1	NNP
cord-022313-2675sjlf	747	1	-phosphotransferase	-phosphotransferase	:
cord-022313-2675sjlf	747	2	:	:	:
cord-022313-2675sjlf	748	1	Proposed	propose	VBN
cord-022313-2675sjlf	748	2	enzyme	enzyme	NN
cord-022313-2675sjlf	748	3	for	for	IN
cord-022313-2675sjlf	748	4	the	the	DT
cord-022313-2675sjlf	748	5	phosphoryla	phosphoryla	NNP
cord-022313-2675sjlf	748	6	tion	tion	NN
cord-022313-2675sjlf	748	7	of	of	IN
cord-022313-2675sjlf	748	8	the	the	DT
cord-022313-2675sjlf	748	9	high	high	JJ
cord-022313-2675sjlf	748	10	mannose	mannose	NN
cord-022313-2675sjlf	748	11	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	748	12	units	unit	NNS
cord-022313-2675sjlf	748	13	of	of	IN
cord-022313-2675sjlf	748	14	lysosomal	lysosomal	JJ
cord-022313-2675sjlf	748	15	enzyme	enzyme	NN
cord-022313-2675sjlf	748	16	Glycosylation	Glycosylation	NNP
cord-022313-2675sjlf	748	17	in	in	IN
cord-022313-2675sjlf	748	18	the	the	DT
cord-022313-2675sjlf	748	19	nucleus	nucleus	NN
cord-022313-2675sjlf	748	20	and	and	CC
cord-022313-2675sjlf	748	21	cytoplasm	cytoplasm	JJ
cord-022313-2675sjlf	749	1	The	the	DT
cord-022313-2675sjlf	749	2	effect	effect	NN
cord-022313-2675sjlf	749	3	of	of	IN
cord-022313-2675sjlf	749	4	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	749	5	on	on	IN
cord-022313-2675sjlf	749	6	wallpolymer	wallpolymer	NNP
cord-022313-2675sjlf	749	7	synthesis	synthesis	NN
cord-022313-2675sjlf	749	8	in	in	IN
cord-022313-2675sjlf	749	9	Bacilli	Bacilli	NNP
cord-022313-2675sjlf	749	10	Inhibition	Inhibition	NNP
cord-022313-2675sjlf	749	11	of	of	IN
cord-022313-2675sjlf	749	12	lipid	lipid	NN
cord-022313-2675sjlf	749	13	-	-	HYPH
cord-022313-2675sjlf	749	14	linked	link	VBN
cord-022313-2675sjlf	749	15	saccharide	saccharide	NN
cord-022313-2675sjlf	749	16	synthesis	synthesis	NN
cord-022313-2675sjlf	749	17	:	:	:
cord-022313-2675sjlf	749	18	Comparison	comparison	NN
cord-022313-2675sjlf	749	19	of	of	IN
cord-022313-2675sjlf	749	20	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	749	21	,	,	,
cord-022313-2675sjlf	749	22	streptovirudin	streptovirudin	NNP
cord-022313-2675sjlf	749	23	,	,	,
cord-022313-2675sjlf	749	24	and	and	CC
cord-022313-2675sjlf	749	25	antibiotic	antibiotic	JJ
cord-022313-2675sjlf	749	26	24010	24010	CD
cord-022313-2675sjlf	750	1	The	the	DT
cord-022313-2675sjlf	750	2	tunicamycins	tunicamycin	NNS
cord-022313-2675sjlf	750	3	-	-	:
cord-022313-2675sjlf	750	4	useful	useful	JJ
cord-022313-2675sjlf	750	5	tools	tool	NNS
cord-022313-2675sjlf	750	6	for	for	IN
cord-022313-2675sjlf	750	7	studies	study	NNS
cord-022313-2675sjlf	750	8	on	on	IN
cord-022313-2675sjlf	750	9	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	750	10	Amplification	amplification	NN
cord-022313-2675sjlf	750	11	and	and	CC
cord-022313-2675sjlf	750	12	molecular	molecular	JJ
cord-022313-2675sjlf	750	13	cloning	cloning	NN
cord-022313-2675sjlf	750	14	of	of	IN
cord-022313-2675sjlf	750	15	the	the	DT
cord-022313-2675sjlf	750	16	hamster	hamster	NN
cord-022313-2675sjlf	750	17	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	750	18	sensitive	sensitive	JJ
cord-022313-2675sjlf	750	19	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	750	20	-	-	HYPH
cord-022313-2675sjlf	750	21	l	l	NN
cord-022313-2675sjlf	750	22	-	-	HYPH
cord-022313-2675sjlf	750	23	P	p	NN
cord-022313-2675sjlf	750	24	transferase	transferase	NN
cord-022313-2675sjlf	750	25	gene	gene	NN
cord-022313-2675sjlf	750	26	:	:	:
cord-022313-2675sjlf	750	27	The	the	DT
cord-022313-2675sjlf	750	28	hamster	hamster	NN
cord-022313-2675sjlf	750	29	and	and	CC
cord-022313-2675sjlf	750	30	yeast	yeast	NN
cord-022313-2675sjlf	750	31	enzymes	enzyme	NNS
cord-022313-2675sjlf	750	32	share	share	VBP
cord-022313-2675sjlf	750	33	a	a	DT
cord-022313-2675sjlf	750	34	common	common	JJ
cord-022313-2675sjlf	750	35	peptide	peptide	NN
cord-022313-2675sjlf	750	36	sequence	sequence	NN
cord-022313-2675sjlf	750	37	Effect	effect	NN
cord-022313-2675sjlf	750	38	of	of	IN
cord-022313-2675sjlf	750	39	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	750	40	on	on	IN
cord-022313-2675sjlf	750	41	the	the	DT
cord-022313-2675sjlf	750	42	secretion	secretion	NN
cord-022313-2675sjlf	750	43	of	of	IN
cord-022313-2675sjlf	750	44	serum	serum	NN
cord-022313-2675sjlf	750	45	proteins	protein	NNS
cord-022313-2675sjlf	750	46	by	by	IN
cord-022313-2675sjlf	750	47	primary	primary	JJ
cord-022313-2675sjlf	750	48	cultures	culture	NNS
cord-022313-2675sjlf	750	49	of	of	IN
cord-022313-2675sjlf	750	50	rat	rat	NN
cord-022313-2675sjlf	750	51	and	and	CC
cord-022313-2675sjlf	750	52	chick	chick	NN
cord-022313-2675sjlf	750	53	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	750	54	Inhibitors	Inhibitors	NNPS
cord-022313-2675sjlf	750	55	of	of	IN
cord-022313-2675sjlf	750	56	the	the	DT
cord-022313-2675sjlf	750	57	addition	addition	NN
cord-022313-2675sjlf	750	58	,	,	,
cord-022313-2675sjlf	750	59	modification	modification	NN
cord-022313-2675sjlf	750	60	or	or	CC
cord-022313-2675sjlf	750	61	processing	processing	NN
cord-022313-2675sjlf	750	62	of	of	IN
cord-022313-2675sjlf	750	63	the	the	DT
cord-022313-2675sjlf	750	64	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	750	65	chains	chain	NNS
cord-022313-2675sjlf	750	66	of	of	IN
cord-022313-2675sjlf	750	67	the	the	DT
cord-022313-2675sjlf	750	68	N	n	NN
cord-022313-2675sjlf	750	69	-	-	HYPH
cord-022313-2675sjlf	750	70	linked	link	VBN
cord-022313-2675sjlf	750	71	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	750	72	Effect	effect	NN
cord-022313-2675sjlf	750	73	of	of	IN
cord-022313-2675sjlf	750	74	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	750	75	and	and	CC
cord-022313-2675sjlf	750	76	cycloheximide	cycloheximide	NN
cord-022313-2675sjlf	750	77	on	on	IN
cord-022313-2675sjlf	750	78	the	the	DT
cord-022313-2675sjlf	750	79	secretion	secretion	NN
cord-022313-2675sjlf	750	80	of	of	IN
cord-022313-2675sjlf	750	81	acid	acid	JJ
cord-022313-2675sjlf	750	82	hydrolases	hydrolase	NNS
cord-022313-2675sjlf	750	83	from	from	IN
cord-022313-2675sjlf	750	84	I	i	NN
cord-022313-2675sjlf	750	85	-	-	HYPH
cord-022313-2675sjlf	750	86	cell	cell	NN
cord-022313-2675sjlf	750	87	cultured	cultured	JJ
cord-022313-2675sjlf	750	88	fibroblasts	fibroblast	NNS
cord-022313-2675sjlf	750	89	Studies	study	NNS
cord-022313-2675sjlf	750	90	of	of	IN
cord-022313-2675sjlf	750	91	the	the	DT
cord-022313-2675sjlf	750	92	mechanism	mechanism	NN
cord-022313-2675sjlf	750	93	of	of	IN
cord-022313-2675sjlf	750	94	tunicamycin	tunicamycin	NNP
cord-022313-2675sjlf	750	95	inhibition	inhibition	NN
cord-022313-2675sjlf	750	96	of	of	IN
cord-022313-2675sjlf	750	97	IgA	IgA	NNP
cord-022313-2675sjlf	750	98	and	and	CC
cord-022313-2675sjlf	750	99	IgE	IgE	NNP
cord-022313-2675sjlf	750	100	secretion	secretion	NN
cord-022313-2675sjlf	750	101	by	by	IN
cord-022313-2675sjlf	750	102	plasma	plasma	NN
cord-022313-2675sjlf	750	103	cells	cell	NNS
cord-022313-2675sjlf	751	1	Differing	differ	VBG
cord-022313-2675sjlf	751	2	requirement	requirement	NN
cord-022313-2675sjlf	751	3	for	for	IN
cord-022313-2675sjlf	751	4	glycosylation	glycosylation	NN
cord-022313-2675sjlf	751	5	in	in	IN
cord-022313-2675sjlf	751	6	the	the	DT
cord-022313-2675sjlf	751	7	secretion	secretion	NN
cord-022313-2675sjlf	751	8	of	of	IN
cord-022313-2675sjlf	751	9	related	related	JJ
cord-022313-2675sjlf	751	10	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	751	11	is	be	VBZ
cord-022313-2675sjlf	751	12	determined	determine	VBN
cord-022313-2675sjlf	751	13	neither	neither	CC
cord-022313-2675sjlf	751	14	by	by	IN
cord-022313-2675sjlf	751	15	the	the	DT
cord-022313-2675sjlf	751	16	producing	produce	VBG
cord-022313-2675sjlf	751	17	cell	cell	NN
cord-022313-2675sjlf	751	18	nor	nor	CC
cord-022313-2675sjlf	751	19	by	by	IN
cord-022313-2675sjlf	751	20	the	the	DT
cord-022313-2675sjlf	751	21	relative	relative	JJ
cord-022313-2675sjlf	751	22	number	number	NN
cord-022313-2675sjlf	751	23	of	of	IN
cord-022313-2675sjlf	751	24	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	751	25	units	unit	NNS
cord-022313-2675sjlf	751	26	Carbohydrate	Carbohydrate	NNP
cord-022313-2675sjlf	751	27	requirement	requirement	NN
cord-022313-2675sjlf	751	28	for	for	IN
cord-022313-2675sjlf	751	29	expression	expression	NN
cord-022313-2675sjlf	751	30	and	and	CC
cord-022313-2675sjlf	751	31	stability	stability	NN
cord-022313-2675sjlf	751	32	of	of	IN
cord-022313-2675sjlf	751	33	acetylcholine	acetylcholine	NN
cord-022313-2675sjlf	751	34	receptor	receptor	NN
cord-022313-2675sjlf	751	35	on	on	IN
cord-022313-2675sjlf	751	36	the	the	DT
cord-022313-2675sjlf	751	37	surface	surface	NN
cord-022313-2675sjlf	751	38	of	of	IN
cord-022313-2675sjlf	751	39	embryonic	embryonic	JJ
cord-022313-2675sjlf	751	40	muscle	muscle	NN
cord-022313-2675sjlf	751	41	cells	cell	NNS
cord-022313-2675sjlf	751	42	in	in	IN
cord-022313-2675sjlf	751	43	cul	cul	NN
cord-022313-2675sjlf	751	44	ture	ture	FW
cord-022313-2675sjlf	751	45	Post	post	JJ
cord-022313-2675sjlf	751	46	-	-	JJ
cord-022313-2675sjlf	751	47	transtional	transtional	JJ
cord-022313-2675sjlf	751	48	processing	processing	NN
cord-022313-2675sjlf	751	49	of	of	IN
cord-022313-2675sjlf	751	50	the	the	DT
cord-022313-2675sjlf	751	51	epidermal	epidermal	JJ
cord-022313-2675sjlf	751	52	growth	growth	NN
cord-022313-2675sjlf	751	53	factor	factor	NN
cord-022313-2675sjlf	751	54	receptor	receptor	NN
cord-022313-2675sjlf	751	55	Effects	effect	NNS
cord-022313-2675sjlf	751	56	of	of	IN
cord-022313-2675sjlf	751	57	tuni	tuni	JJ
cord-022313-2675sjlf	751	58	camycin	camycin	NNS
cord-022313-2675sjlf	751	59	on	on	IN
cord-022313-2675sjlf	751	60	the	the	DT
cord-022313-2675sjlf	751	61	binding	binding	NN
cord-022313-2675sjlf	751	62	and	and	CC
cord-022313-2675sjlf	751	63	degradation	degradation	NN
cord-022313-2675sjlf	751	64	of	of	IN
cord-022313-2675sjlf	751	65	low	low	JJ
cord-022313-2675sjlf	751	66	density	density	NN
cord-022313-2675sjlf	751	67	lipoproteins	lipoprotein	NNS
cord-022313-2675sjlf	751	68	and	and	CC
cord-022313-2675sjlf	751	69	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	751	70	synthesis	synthesis	NN
cord-022313-2675sjlf	751	71	in	in	IN
cord-022313-2675sjlf	751	72	cultured	cultured	JJ
cord-022313-2675sjlf	751	73	human	human	JJ
cord-022313-2675sjlf	751	74	fibroblasts	fibroblast	NNS
cord-022313-2675sjlf	751	75	Effects	effect	NNS
cord-022313-2675sjlf	751	76	of	of	IN
cord-022313-2675sjlf	751	77	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	751	78	on	on	IN
cord-022313-2675sjlf	751	79	NGF	NGF	NNP
cord-022313-2675sjlf	751	80	binding	binding	NN
cord-022313-2675sjlf	751	81	and	and	CC
cord-022313-2675sjlf	751	82	neurite	neurite	NN
cord-022313-2675sjlf	751	83	outgrowth	outgrowth	NN
cord-022313-2675sjlf	751	84	in	in	IN
cord-022313-2675sjlf	751	85	PC	pc	NN
cord-022313-2675sjlf	751	86	12	12	CD
cord-022313-2675sjlf	751	87	cells	cell	NNS
cord-022313-2675sjlf	752	1	Post	post	JJ
cord-022313-2675sjlf	752	2	-	-	JJ
cord-022313-2675sjlf	752	3	translational	translational	JJ
cord-022313-2675sjlf	752	4	glycosylation	glycosylation	NN
cord-022313-2675sjlf	752	5	induced	induce	VBN
cord-022313-2675sjlf	752	6	activation	activation	NN
cord-022313-2675sjlf	752	7	of	of	IN
cord-022313-2675sjlf	752	8	aglycoinsulin	aglycoinsulin	NNP
cord-022313-2675sjlf	752	9	receptor	receptor	NN
cord-022313-2675sjlf	752	10	accumulated	accumulate	VBN
cord-022313-2675sjlf	752	11	during	during	IN
cord-022313-2675sjlf	752	12	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	752	13	treatment	treatment	NN
cord-022313-2675sjlf	752	14	Intracellular	Intracellular	NNP
cord-022313-2675sjlf	752	15	movement	movement	NN
cord-022313-2675sjlf	752	16	of	of	IN
cord-022313-2675sjlf	752	17	cell	cell	NN
cord-022313-2675sjlf	752	18	surface	surface	NN
cord-022313-2675sjlf	752	19	recep	recep	NNP
cord-022313-2675sjlf	752	20	tors	tor	NNS
cord-022313-2675sjlf	752	21	after	after	IN
cord-022313-2675sjlf	752	22	endocytosis	endocytosis	NN
cord-022313-2675sjlf	752	23	:	:	:
cord-022313-2675sjlf	753	1	Resialylation	Resialylation	NNP
cord-022313-2675sjlf	753	2	of	of	IN
cord-022313-2675sjlf	753	3	asialo	asialo	NNP
cord-022313-2675sjlf	753	4	-	-	HYPH
cord-022313-2675sjlf	753	5	transferase	transferase	NN
cord-022313-2675sjlf	753	6	receptor	receptor	NN
cord-022313-2675sjlf	753	7	in	in	IN
cord-022313-2675sjlf	753	8	human	human	JJ
cord-022313-2675sjlf	753	9	erythroleukemia	erythroleukemia	NN
cord-022313-2675sjlf	753	10	cells	cell	NNS
cord-022313-2675sjlf	753	11	Glycosylation	Glycosylation	NNP
cord-022313-2675sjlf	753	12	of	of	IN
cord-022313-2675sjlf	753	13	thyroidstimulating	thyroidstimulate	VBG
cord-022313-2675sjlf	753	14	hormone	hormone	NN
cord-022313-2675sjlf	753	15	in	in	IN
cord-022313-2675sjlf	753	16	pituitary	pituitary	JJ
cord-022313-2675sjlf	753	17	tumor	tumor	NN
cord-022313-2675sjlf	753	18	cells	cell	NNS
cord-022313-2675sjlf	753	19	:	:	:
cord-022313-2675sjlf	753	20	Influence	influence	NN
cord-022313-2675sjlf	753	21	of	of	IN
cord-022313-2675sjlf	753	22	high	high	JJ
cord-022313-2675sjlf	753	23	mannose	mannose	NN
cord-022313-2675sjlf	753	24	oligosac	oligosac	NNP
cord-022313-2675sjlf	753	25	charides	charides	NNP
cord-022313-2675sjlf	753	26	units	unit	NNS
cord-022313-2675sjlf	753	27	on	on	IN
cord-022313-2675sjlf	753	28	subunit	subunit	NN
cord-022313-2675sjlf	753	29	aggregation	aggregation	NN
cord-022313-2675sjlf	753	30	Suppression	Suppression	NNP
cord-022313-2675sjlf	753	31	of	of	IN
cord-022313-2675sjlf	753	32	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	753	33	formation	formation	NN
cord-022313-2675sjlf	753	34	of	of	IN
cord-022313-2675sjlf	753	35	semliki	semliki	NNP
cord-022313-2675sjlf	753	36	forest	forest	NNP
cord-022313-2675sjlf	753	37	,	,	,
cord-022313-2675sjlf	753	38	influenza	influenza	NN
cord-022313-2675sjlf	753	39	,	,	,
cord-022313-2675sjlf	753	40	and	and	CC
cord-022313-2675sjlf	753	41	avian	avian	JJ
cord-022313-2675sjlf	753	42	sarcoma	sarcoma	NN
cord-022313-2675sjlf	753	43	virus	virus	NN
cord-022313-2675sjlf	753	44	by	by	IN
cord-022313-2675sjlf	753	45	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	754	1	The	the	DT
cord-022313-2675sjlf	754	2	nonglycosylated	nonglycosylated	JJ
cord-022313-2675sjlf	754	3	glycopro	glycopro	NNP
cord-022313-2675sjlf	754	4	tein	tein	NNP
cord-022313-2675sjlf	754	5	of	of	IN
cord-022313-2675sjlf	754	6	vesicular	vesicular	JJ
cord-022313-2675sjlf	754	7	stomatitis	stomatitis	NN
cord-022313-2675sjlf	754	8	virus	virus	NN
cord-022313-2675sjlf	754	9	is	be	VBZ
cord-022313-2675sjlf	754	10	temperature	temperature	NN
cord-022313-2675sjlf	754	11	-	-	HYPH
cord-022313-2675sjlf	754	12	sensitive	sensitive	JJ
cord-022313-2675sjlf	754	13	and	and	CC
cord-022313-2675sjlf	754	14	undergoes	undergo	VBZ
cord-022313-2675sjlf	754	15	intracellu	intracellu	NNP
cord-022313-2675sjlf	754	16	lar	lar	NNP
cord-022313-2675sjlf	754	17	aggregation	aggregation	NN
cord-022313-2675sjlf	754	18	at	at	IN
cord-022313-2675sjlf	754	19	elevated	elevated	JJ
cord-022313-2675sjlf	754	20	temperatures	temperature	NNS
cord-022313-2675sjlf	754	21	Streptovirudins	Streptovirudins	NNP
cord-022313-2675sjlf	754	22	of	of	IN
cord-022313-2675sjlf	754	23	series	series	NN
cord-022313-2675sjlf	754	24	I	I	NNP
cord-022313-2675sjlf	754	25	and	and	CC
cord-022313-2675sjlf	754	26	II	II	NNP
cord-022313-2675sjlf	754	27	:	:	:
cord-022313-2675sjlf	755	1	Chemical	chemical	JJ
cord-022313-2675sjlf	755	2	and	and	CC
cord-022313-2675sjlf	755	3	biological	biological	JJ
cord-022313-2675sjlf	755	4	properties	property	NNS
cord-022313-2675sjlf	756	1	Comparison	comparison	NN
cord-022313-2675sjlf	756	2	of	of	IN
cord-022313-2675sjlf	756	3	the	the	DT
cord-022313-2675sjlf	756	4	biological	biological	JJ
cord-022313-2675sjlf	756	5	and	and	CC
cord-022313-2675sjlf	756	6	chemical	chemical	JJ
cord-022313-2675sjlf	756	7	properties	property	NNS
cord-022313-2675sjlf	756	8	of	of	IN
cord-022313-2675sjlf	756	9	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	756	10	and	and	CC
cord-022313-2675sjlf	756	11	mycospocidin	mycospocidin	NNP
cord-022313-2675sjlf	756	12	Anomeric	Anomeric	NNP
cord-022313-2675sjlf	756	13	configuration	configuration	NN
cord-022313-2675sjlf	756	14	of	of	IN
cord-022313-2675sjlf	756	15	ΑΓ	ΑΓ	NNP
cord-022313-2675sjlf	756	16	-	-	HYPH
cord-022313-2675sjlf	756	17	acetylglucosaminyl	acetylglucosaminyl	NNP
cord-022313-2675sjlf	756	18	phosphorylundecaprenols	phosphorylundecaprenol	NNS
cord-022313-2675sjlf	756	19	formed	form	VBN
cord-022313-2675sjlf	756	20	in	in	IN
cord-022313-2675sjlf	756	21	Bacillus	Bacillus	NNP
cord-022313-2675sjlf	756	22	cereus	cereus	NN
cord-022313-2675sjlf	756	23	mem	mem	NN
cord-022313-2675sjlf	756	24	branes	brane	NNS
cord-022313-2675sjlf	756	25	Holomycin	Holomycin	NNPS
cord-022313-2675sjlf	756	26	and	and	CC
cord-022313-2675sjlf	756	27	an	an	DT
cord-022313-2675sjlf	756	28	antibiotic	antibiotic	NN
cord-022313-2675sjlf	756	29	(	(	-LRB-
cord-022313-2675sjlf	756	30	MM	MM	NNP
cord-022313-2675sjlf	756	31	19290	19290	CD
cord-022313-2675sjlf	756	32	)	)	-RRB-
cord-022313-2675sjlf	756	33	related	relate	VBN
cord-022313-2675sjlf	756	34	to	to	IN
cord-022313-2675sjlf	756	35	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	756	36	Glycolipid	Glycolipid	NNP
cord-022313-2675sjlf	756	37	toxins	toxin	NNS
cord-022313-2675sjlf	756	38	from	from	IN
cord-022313-2675sjlf	756	39	parasitised	parasitised	JJ
cord-022313-2675sjlf	756	40	annual	annual	JJ
cord-022313-2675sjlf	756	41	ryegrass	ryegrass	NN
cord-022313-2675sjlf	756	42	:	:	:
cord-022313-2675sjlf	756	43	A	a	DT
cord-022313-2675sjlf	756	44	comparison	comparison	NN
cord-022313-2675sjlf	756	45	with	with	IN
cord-022313-2675sjlf	756	46	tunicamycin	tunicamycin	NNP
cord-022313-2675sjlf	756	47	Studies	study	NNS
cord-022313-2675sjlf	756	48	on	on	IN
cord-022313-2675sjlf	756	49	bacterial	bacterial	JJ
cord-022313-2675sjlf	756	50	cell	cell	NN
cord-022313-2675sjlf	756	51	wall	wall	NN
cord-022313-2675sjlf	756	52	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	757	1	Enzymatic	enzymatic	JJ
cord-022313-2675sjlf	757	2	activities	activity	NNS
cord-022313-2675sjlf	757	3	in	in	IN
cord-022313-2675sjlf	757	4	cultured	cultured	JJ
cord-022313-2675sjlf	757	5	human	human	JJ
cord-022313-2675sjlf	757	6	lymphocytes	lymphocyte	NNS
cord-022313-2675sjlf	757	7	that	that	WDT
cord-022313-2675sjlf	757	8	dephosphorylate	dephosphorylate	NNP
cord-022313-2675sjlf	757	9	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	757	10	pyrophosphate	pyrophosphate	NNP
cord-022313-2675sjlf	757	11	and	and	CC
cord-022313-2675sjlf	757	12	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	757	13	phosphate	phosphate	NNP
cord-022313-2675sjlf	757	14	Structure	Structure	NNP
cord-022313-2675sjlf	757	15	of	of	IN
cord-022313-2675sjlf	757	16	the	the	DT
cord-022313-2675sjlf	757	17	peptide	peptide	NN
cord-022313-2675sjlf	757	18	antibi	antibi	NNP
cord-022313-2675sjlf	757	19	otic	otic	NNP
cord-022313-2675sjlf	757	20	amphomycin	amphomycin	NNP
cord-022313-2675sjlf	757	21	Stimulation	stimulation	NN
cord-022313-2675sjlf	757	22	of	of	IN
cord-022313-2675sjlf	757	23	lipid	lipid	NN
cord-022313-2675sjlf	757	24	-	-	HYPH
cord-022313-2675sjlf	757	25	linked	link	VBN
cord-022313-2675sjlf	757	26	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	757	27	assembly	assembly	NN
cord-022313-2675sjlf	757	28	during	during	IN
cord-022313-2675sjlf	757	29	oviduct	oviduct	NN
cord-022313-2675sjlf	757	30	differentiation	differentiation	NN
cord-022313-2675sjlf	757	31	Biosynthesis	Biosynthesis	NNP
cord-022313-2675sjlf	757	32	of	of	IN
cord-022313-2675sjlf	757	33	lipid	lipid	NN
cord-022313-2675sjlf	757	34	-	-	HYPH
cord-022313-2675sjlf	757	35	linked	link	VBN
cord-022313-2675sjlf	757	36	oligosaccha	oligosaccha	NN
cord-022313-2675sjlf	757	37	rides	ride	NNS
cord-022313-2675sjlf	757	38	in	in	IN
cord-022313-2675sjlf	757	39	embryonic	embryonic	JJ
cord-022313-2675sjlf	757	40	liver	liver	NN
cord-022313-2675sjlf	757	41	:	:	:
cord-022313-2675sjlf	757	42	Formation	formation	NN
cord-022313-2675sjlf	757	43	of	of	IN
cord-022313-2675sjlf	757	44	mannose	mannose	NN
cord-022313-2675sjlf	757	45	containing	contain	VBG
cord-022313-2675sjlf	757	46	derivatives	derivative	NNS
cord-022313-2675sjlf	757	47	Amphomycin	Amphomycin	NNP
cord-022313-2675sjlf	757	48	:	:	:
cord-022313-2675sjlf	757	49	Effect	effect	NN
cord-022313-2675sjlf	757	50	of	of	IN
cord-022313-2675sjlf	757	51	the	the	DT
cord-022313-2675sjlf	757	52	lipopeptide	lipopeptide	NN
cord-022313-2675sjlf	757	53	antibiotic	antibiotic	NN
cord-022313-2675sjlf	757	54	and	and	CC
cord-022313-2675sjlf	757	55	the	the	DT
cord-022313-2675sjlf	757	56	glycosylation	glycosylation	NN
cord-022313-2675sjlf	757	57	and	and	CC
cord-022313-2675sjlf	757	58	extraction	extraction	NN
cord-022313-2675sjlf	757	59	of	of	IN
cord-022313-2675sjlf	757	60	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	757	61	monophos	monophos	NNP
cord-022313-2675sjlf	757	62	phate	phate	NNP
cord-022313-2675sjlf	757	63	in	in	IN
cord-022313-2675sjlf	757	64	calf	calf	NN
cord-022313-2675sjlf	757	65	brain	brain	NN
cord-022313-2675sjlf	757	66	membranes	membrane	NNS
cord-022313-2675sjlf	757	67	Stimulation	stimulation	NN
cord-022313-2675sjlf	757	68	by	by	IN
cord-022313-2675sjlf	757	69	dolichol	dolichol	JJ
cord-022313-2675sjlf	757	70	phosphate	phosphate	NN
cord-022313-2675sjlf	757	71	mannose	mannose	NN
cord-022313-2675sjlf	757	72	and	and	CC
cord-022313-2675sjlf	757	73	phospholipids	phospholipid	NNS
cord-022313-2675sjlf	757	74	of	of	IN
cord-022313-2675sjlf	757	75	the	the	DT
cord-022313-2675sjlf	757	76	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	757	77	of	of	IN
cord-022313-2675sjlf	757	78	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	757	79	-	-	HYPH
cord-022313-2675sjlf	757	80	PP	PP	NNP
cord-022313-2675sjlf	757	81	-	-	HYPH
cord-022313-2675sjlf	757	82	dolichol	dolichol	NNP
cord-022313-2675sjlf	757	83	Dolichyl	Dolichyl	NNP
cord-022313-2675sjlf	757	84	phosphate	phosphate	NN
cord-022313-2675sjlf	757	85	-	-	HYPH
cord-022313-2675sjlf	757	86	mediated	mediate	VBN
cord-022313-2675sjlf	757	87	mannosyl	mannosyl	NNP
cord-022313-2675sjlf	757	88	transfer	transfer	NN
cord-022313-2675sjlf	757	89	through	through	IN
cord-022313-2675sjlf	757	90	liposomal	liposomal	JJ
cord-022313-2675sjlf	757	91	membranes	membrane	NNS
cord-022313-2675sjlf	758	1	The	the	DT
cord-022313-2675sjlf	758	2	effect	effect	NN
cord-022313-2675sjlf	758	3	of	of	IN
cord-022313-2675sjlf	758	4	tsushimycin	tsushimycin	NNS
cord-022313-2675sjlf	758	5	on	on	IN
cord-022313-2675sjlf	758	6	the	the	DT
cord-022313-2675sjlf	758	7	synthesis	synthesis	NN
cord-022313-2675sjlf	758	8	of	of	IN
cord-022313-2675sjlf	758	9	lipid	lipid	NN
cord-022313-2675sjlf	758	10	-	-	HYPH
cord-022313-2675sjlf	758	11	linked	link	VBN
cord-022313-2675sjlf	758	12	saccharides	saccharide	NNS
cord-022313-2675sjlf	758	13	in	in	IN
cord-022313-2675sjlf	758	14	aorta	aorta	JJ
cord-022313-2675sjlf	758	15	Inhibition	inhibition	NN
cord-022313-2675sjlf	758	16	of	of	IN
cord-022313-2675sjlf	758	17	lipid	lipid	NN
cord-022313-2675sjlf	758	18	-	-	HYPH
cord-022313-2675sjlf	758	19	linked	link	VBN
cord-022313-2675sjlf	758	20	saccharide	saccharide	NN
cord-022313-2675sjlf	758	21	synthesis	synthesis	NN
cord-022313-2675sjlf	758	22	by	by	IN
cord-022313-2675sjlf	758	23	bacitracin	bacitracin	NNP
cord-022313-2675sjlf	758	24	Inhibition	Inhibition	NNP
cord-022313-2675sjlf	758	25	of	of	IN
cord-022313-2675sjlf	758	26	lipid	lipid	NN
cord-022313-2675sjlf	758	27	-	-	HYPH
cord-022313-2675sjlf	758	28	linked	link	VBN
cord-022313-2675sjlf	758	29	mannose	mannose	NN
cord-022313-2675sjlf	758	30	and	and	CC
cord-022313-2675sjlf	758	31	mannoprotein	mannoprotein	NNP
cord-022313-2675sjlf	758	32	synthe	synthe	NNP
cord-022313-2675sjlf	758	33	sis	sis	NNP
cord-022313-2675sjlf	758	34	in	in	IN
cord-022313-2675sjlf	758	35	yeast	yeast	NN
cord-022313-2675sjlf	758	36	by	by	IN
cord-022313-2675sjlf	758	37	diumycin	diumycin	NNS
cord-022313-2675sjlf	758	38	in	in	IN
cord-022313-2675sjlf	758	39	vitro	vitro	FW
cord-022313-2675sjlf	758	40	Properties	property	NNS
cord-022313-2675sjlf	758	41	of	of	IN
cord-022313-2675sjlf	758	42	a	a	DT
cord-022313-2675sjlf	758	43	soluble	soluble	JJ
cord-022313-2675sjlf	758	44	polyprenyl	polyprenyl	NNP
cord-022313-2675sjlf	758	45	phos	phos	NNP
cord-022313-2675sjlf	758	46	phate	phate	NNP
cord-022313-2675sjlf	758	47	:	:	:
cord-022313-2675sjlf	759	1	UDP	udp	NN
cord-022313-2675sjlf	759	2	-	-	HYPH
cord-022313-2675sjlf	759	3	D	D	NNP
cord-022313-2675sjlf	759	4	-	-	HYPH
cord-022313-2675sjlf	759	5	Af	Af	NNP
cord-022313-2675sjlf	759	6	-	-	HYPH
cord-022313-2675sjlf	759	7	acetylglucosamine	acetylglucosamine	NNP
cord-022313-2675sjlf	759	8	iV	iv	CD
cord-022313-2675sjlf	759	9	-	-	HYPH
cord-022313-2675sjlf	759	10	acetylglucosamine	acetylglucosamine	NNP
cord-022313-2675sjlf	759	11	-	-	HYPH
cord-022313-2675sjlf	759	12	l	l	NN
cord-022313-2675sjlf	759	13	-	-	HYPH
cord-022313-2675sjlf	759	14	phosphate	phosphate	NN
cord-022313-2675sjlf	759	15	transferase	transferase	NN
cord-022313-2675sjlf	760	1	The	the	DT
cord-022313-2675sjlf	760	2	effect	effect	NN
cord-022313-2675sjlf	760	3	of	of	IN
cord-022313-2675sjlf	760	4	flavomycin	flavomycin	NNS
cord-022313-2675sjlf	760	5	on	on	IN
cord-022313-2675sjlf	760	6	the	the	DT
cord-022313-2675sjlf	760	7	synthesis	synthesis	NN
cord-022313-2675sjlf	760	8	and	and	CC
cord-022313-2675sjlf	760	9	transfer	transfer	NN
cord-022313-2675sjlf	760	10	of	of	IN
cord-022313-2675sjlf	760	11	lipid	lipid	NN
cord-022313-2675sjlf	760	12	-	-	HYPH
cord-022313-2675sjlf	760	13	linked	link	VBN
cord-022313-2675sjlf	760	14	saccharides	saccharide	NNS
cord-022313-2675sjlf	760	15	in	in	IN
cord-022313-2675sjlf	760	16	pig	pig	NN
cord-022313-2675sjlf	760	17	brain	brain	NN
cord-022313-2675sjlf	761	1	The	the	DT
cord-022313-2675sjlf	761	2	effect	effect	NN
cord-022313-2675sjlf	761	3	of	of	IN
cord-022313-2675sjlf	761	4	showdomycin	showdomycin	NNS
cord-022313-2675sjlf	761	5	on	on	IN
cord-022313-2675sjlf	761	6	glycolipid	glycolipid	NNP
cord-022313-2675sjlf	761	7	formation	formation	NN
cord-022313-2675sjlf	761	8	:	:	:
cord-022313-2675sjlf	762	1	Inhibition	inhibition	NN
cord-022313-2675sjlf	762	2	of	of	IN
cord-022313-2675sjlf	762	3	glucosyl	glucosyl	NNP
cord-022313-2675sjlf	762	4	-	-	HYPH
cord-022313-2675sjlf	762	5	phosphoryl	phosphoryl	NNP
cord-022313-2675sjlf	762	6	-	-	HYPH
cord-022313-2675sjlf	762	7	dolichol	dolichol	JJ
cord-022313-2675sjlf	762	8	in	in	IN
cord-022313-2675sjlf	762	9	aorta	aorta	NN
cord-022313-2675sjlf	762	10	and	and	CC
cord-022313-2675sjlf	762	11	simulation	simulation	NN
cord-022313-2675sjlf	762	12	of	of	IN
cord-022313-2675sjlf	762	13	glycosylceramide	glycosylceramide	NN
cord-022313-2675sjlf	762	14	in	in	IN
cord-022313-2675sjlf	762	15	yeast	yeast	NN
cord-022313-2675sjlf	762	16	Glycolipid	Glycolipid	NNP
cord-022313-2675sjlf	762	17	formation	formation	NN
cord-022313-2675sjlf	762	18	in	in	IN
cord-022313-2675sjlf	762	19	Volvox	Volvox	NNP
cord-022313-2675sjlf	762	20	carteri	carteri	NNP
cord-022313-2675sjlf	762	21	f	f	NNP
cord-022313-2675sjlf	762	22	nagariensis	nagariensis	NN
cord-022313-2675sjlf	762	23	:	:	:
cord-022313-2675sjlf	762	24	Efects	Efects	NNP
cord-022313-2675sjlf	762	25	of	of	IN
cord-022313-2675sjlf	762	26	tunicamycin	tunicamycin	NNS
cord-022313-2675sjlf	762	27	and	and	CC
cord-022313-2675sjlf	762	28	showdomycin	showdomycin	NNS
cord-022313-2675sjlf	762	29	Effect	Effect	NNP
cord-022313-2675sjlf	762	30	of	of	IN
cord-022313-2675sjlf	762	31	2-deoxy	2-deoxy	NNP
cord-022313-2675sjlf	762	32	-	-	HYPH
cord-022313-2675sjlf	762	33	Dglucose	Dglucose	NNP
cord-022313-2675sjlf	762	34	on	on	IN
cord-022313-2675sjlf	762	35	the	the	DT
cord-022313-2675sjlf	762	36	multiplication	multiplication	NN
cord-022313-2675sjlf	762	37	of	of	IN
cord-022313-2675sjlf	762	38	semliki	semliki	NNP
cord-022313-2675sjlf	762	39	forest	forest	NNP
cord-022313-2675sjlf	762	40	virus	virus	NNP
cord-022313-2675sjlf	762	41	and	and	CC
cord-022313-2675sjlf	762	42	the	the	DT
cord-022313-2675sjlf	762	43	reversal	reversal	NN
cord-022313-2675sjlf	762	44	of	of	IN
cord-022313-2675sjlf	762	45	the	the	DT
cord-022313-2675sjlf	762	46	block	block	NN
cord-022313-2675sjlf	762	47	by	by	IN
cord-022313-2675sjlf	762	48	mannose	mannose	VBG
cord-022313-2675sjlf	762	49	Carbohy	Carbohy	NNP
cord-022313-2675sjlf	762	50	drates	drate	NNS
cord-022313-2675sjlf	762	51	of	of	IN
cord-022313-2675sjlf	762	52	influenza	influenza	NN
cord-022313-2675sjlf	762	53	virus	virus	NN
cord-022313-2675sjlf	762	54	.	.	.
cord-022313-2675sjlf	763	1	I.	I.	NNP
cord-022313-2675sjlf	763	2	Glycopeptides	Glycopeptides	NNP
cord-022313-2675sjlf	763	3	derived	derive	VBN
cord-022313-2675sjlf	763	4	from	from	IN
cord-022313-2675sjlf	763	5	viral	viral	JJ
cord-022313-2675sjlf	763	6	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	763	7	after	after	IN
cord-022313-2675sjlf	763	8	labeling	labeling	NN
cord-022313-2675sjlf	763	9	of	of	IN
cord-022313-2675sjlf	763	10	its	-PRON-	PRP$
cord-022313-2675sjlf	763	11	radioactive	radioactive	JJ
cord-022313-2675sjlf	763	12	sugars	sugar	NNS
cord-022313-2675sjlf	763	13	The	the	DT
cord-022313-2675sjlf	763	14	lipid	lipid	NN
cord-022313-2675sjlf	763	15	pathway	pathway	NN
cord-022313-2675sjlf	763	16	of	of	IN
cord-022313-2675sjlf	763	17	protein	protein	NN
cord-022313-2675sjlf	763	18	glycosylation	glycosylation	NN
cord-022313-2675sjlf	763	19	and	and	CC
cord-022313-2675sjlf	763	20	its	-PRON-	PRP$
cord-022313-2675sjlf	763	21	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	764	1	The	the	DT
cord-022313-2675sjlf	764	2	formation	formation	NN
cord-022313-2675sjlf	764	3	of	of	IN
cord-022313-2675sjlf	764	4	lipid	lipid	NN
cord-022313-2675sjlf	764	5	-	-	HYPH
cord-022313-2675sjlf	764	6	linked	link	VBN
cord-022313-2675sjlf	764	7	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	764	8	in	in	IN
cord-022313-2675sjlf	764	9	Madin	Madin	NNP
cord-022313-2675sjlf	764	10	-	-	HYPH
cord-022313-2675sjlf	764	11	Darby	Darby	NNP
cord-022313-2675sjlf	764	12	canine	canine	JJ
cord-022313-2675sjlf	764	13	kidney	kidney	NN
cord-022313-2675sjlf	764	14	cells	cell	NNS
cord-022313-2675sjlf	764	15	:	:	:
cord-022313-2675sjlf	764	16	Changes	change	NNS
cord-022313-2675sjlf	764	17	in	in	IN
cord-022313-2675sjlf	764	18	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	764	19	profiles	profile	NNS
cord-022313-2675sjlf	764	20	induced	induce	VBN
cord-022313-2675sjlf	764	21	by	by	IN
cord-022313-2675sjlf	764	22	glucosamine	glucosamine	NNP
cord-022313-2675sjlf	764	23	Formation	Formation	NNP
cord-022313-2675sjlf	764	24	of	of	IN
cord-022313-2675sjlf	764	25	unusual	unusual	JJ
cord-022313-2675sjlf	764	26	mannosamine	mannosamine	NN
cord-022313-2675sjlf	764	27	-	-	HYPH
cord-022313-2675sjlf	764	28	containing	contain	VBG
cord-022313-2675sjlf	764	29	lipid	lipid	NN
cord-022313-2675sjlf	764	30	-	-	HYPH
cord-022313-2675sjlf	764	31	linked	link	VBN
cord-022313-2675sjlf	764	32	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	764	33	in	in	IN
cord-022313-2675sjlf	764	34	MDCK	MDCK	NNP
cord-022313-2675sjlf	764	35	cells	cell	NNS
cord-022313-2675sjlf	764	36	Formation	Formation	NNP
cord-022313-2675sjlf	764	37	of	of	IN
cord-022313-2675sjlf	764	38	2-deoxyglucose	2-deoxyglucose	CD
cord-022313-2675sjlf	764	39	-	-	HYPH
cord-022313-2675sjlf	764	40	containing	contain	VBG
cord-022313-2675sjlf	764	41	lipid	lipid	NN
cord-022313-2675sjlf	764	42	-	-	HYPH
cord-022313-2675sjlf	764	43	linked	link	VBN
cord-022313-2675sjlf	764	44	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	764	45	:	:	:
cord-022313-2675sjlf	764	46	Interference	interference	NN
cord-022313-2675sjlf	764	47	with	with	IN
cord-022313-2675sjlf	764	48	glycosylation	glycosylation	NN
cord-022313-2675sjlf	764	49	of	of	IN
cord-022313-2675sjlf	764	50	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	764	51	Mechanism	mechanism	NN
cord-022313-2675sjlf	764	52	of	of	IN
cord-022313-2675sjlf	764	53	inhibition	inhibition	NN
cord-022313-2675sjlf	764	54	of	of	IN
cord-022313-2675sjlf	764	55	protein	protein	NN
cord-022313-2675sjlf	764	56	glycosylation	glycosylation	NN
cord-022313-2675sjlf	764	57	by	by	IN
cord-022313-2675sjlf	764	58	the	the	DT
cord-022313-2675sjlf	764	59	antiviral	antiviral	JJ
cord-022313-2675sjlf	764	60	sugar	sugar	NN
cord-022313-2675sjlf	764	61	analogue	analogue	NN
cord-022313-2675sjlf	764	62	2-deoxy-2-fluoro	2-deoxy-2-fluoro	CD
cord-022313-2675sjlf	765	1	-D	-d	NN
cord-022313-2675sjlf	765	2	-	-	HYPH
cord-022313-2675sjlf	765	3	mannose	mannose	NN
cord-022313-2675sjlf	765	4	:	:	:
cord-022313-2675sjlf	765	5	Inhibition	inhibition	NN
cord-022313-2675sjlf	765	6	of	of	IN
cord-022313-2675sjlf	765	7	synthesis	synthesis	NN
cord-022313-2675sjlf	765	8	of	of	IN
cord-022313-2675sjlf	765	9	Man	Man	NNP
cord-022313-2675sjlf	765	10	(	(	-LRB-
cord-022313-2675sjlf	765	11	GlcNAc	GlcNAc	NNP
cord-022313-2675sjlf	765	12	)	)	-RRB-
cord-022313-2675sjlf	765	13	2	2	CD
cord-022313-2675sjlf	765	14	-PP	-PP	NNS
cord-022313-2675sjlf	765	15	-	-	HYPH
cord-022313-2675sjlf	765	16	Dol	dol	NN
cord-022313-2675sjlf	765	17	by	by	IN
cord-022313-2675sjlf	765	18	the	the	DT
cord-022313-2675sjlf	765	19	guanosine	guanosine	NN
cord-022313-2675sjlf	765	20	diphosphate	diphosphate	NN
cord-022313-2675sjlf	765	21	ester	ester	NN
cord-022313-2675sjlf	765	22	Glucose	Glucose	NNP
cord-022313-2675sjlf	765	23	starvation	starvation	NN
cord-022313-2675sjlf	765	24	alters	alter	VBZ
cord-022313-2675sjlf	765	25	lipid	lipid	NN
cord-022313-2675sjlf	765	26	-	-	HYPH
cord-022313-2675sjlf	765	27	linked	link	VBN
cord-022313-2675sjlf	765	28	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	765	29	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	765	30	in	in	IN
cord-022313-2675sjlf	765	31	Chinese	chinese	JJ
cord-022313-2675sjlf	765	32	hamster	hamster	NN
cord-022313-2675sjlf	765	33	ovary	ovary	NN
cord-022313-2675sjlf	765	34	cells	cell	VBZ
cord-022313-2675sjlf	765	35	Transitory	transitory	JJ
cord-022313-2675sjlf	765	36	effects	effect	NNS
cord-022313-2675sjlf	765	37	of	of	IN
cord-022313-2675sjlf	765	38	glucose	glucose	NN
cord-022313-2675sjlf	765	39	starvation	starvation	NN
cord-022313-2675sjlf	765	40	on	on	IN
cord-022313-2675sjlf	765	41	the	the	DT
cord-022313-2675sjlf	765	42	synthesis	synthesis	NN
cord-022313-2675sjlf	765	43	of	of	IN
cord-022313-2675sjlf	765	44	dolichol	dolichol	NNP
cord-022313-2675sjlf	765	45	-	-	HYPH
cord-022313-2675sjlf	765	46	linked	link	VBN
cord-022313-2675sjlf	765	47	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	765	48	in	in	IN
cord-022313-2675sjlf	765	49	mammalian	mammalian	JJ
cord-022313-2675sjlf	765	50	cells	cell	NNS
cord-022313-2675sjlf	765	51	Modification	modification	NN
cord-022313-2675sjlf	765	52	of	of	IN
cord-022313-2675sjlf	765	53	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	765	54	-	-	HYPH
cord-022313-2675sjlf	765	55	lipid	lipid	NN
cord-022313-2675sjlf	765	56	synthesis	synthesis	NN
cord-022313-2675sjlf	765	57	and	and	CC
cord-022313-2675sjlf	766	1	protein	protein	NNP
cord-022313-2675sjlf	766	2	glyco	glyco	NNP
cord-022313-2675sjlf	766	3	sylation	sylation	NN
cord-022313-2675sjlf	766	4	in	in	IN
cord-022313-2675sjlf	766	5	glucose	glucose	NN
cord-022313-2675sjlf	766	6	-	-	HYPH
cord-022313-2675sjlf	766	7	deprived	deprive	VBN
cord-022313-2675sjlf	766	8	cells	cell	NNS
cord-022313-2675sjlf	766	9	Altered	alter	VBD
cord-022313-2675sjlf	766	10	G	g	NN
cord-022313-2675sjlf	766	11	-	-	HYPH
cord-022313-2675sjlf	766	12	protein	protein	NN
cord-022313-2675sjlf	766	13	glycosylation	glycosylation	NN
cord-022313-2675sjlf	766	14	in	in	IN
cord-022313-2675sjlf	766	15	vesicular	vesicular	JJ
cord-022313-2675sjlf	766	16	stomatitis	stomatitis	NN
cord-022313-2675sjlf	766	17	virus	virus	NN
cord-022313-2675sjlf	766	18	-	-	HYPH
cord-022313-2675sjlf	766	19	infected	infect	VBN
cord-022313-2675sjlf	766	20	glucose	glucose	NN
cord-022313-2675sjlf	766	21	-	-	HYPH
cord-022313-2675sjlf	766	22	deprived	deprive	VBN
cord-022313-2675sjlf	766	23	baby	baby	NN
cord-022313-2675sjlf	766	24	hamster	hamster	NN
cord-022313-2675sjlf	766	25	kidney	kidney	NN
cord-022313-2675sjlf	766	26	cells	cell	NNS
cord-022313-2675sjlf	766	27	Effect	effect	NN
cord-022313-2675sjlf	766	28	of	of	IN
cord-022313-2675sjlf	766	29	the	the	DT
cord-022313-2675sjlf	766	30	threonine	threonine	NN
cord-022313-2675sjlf	766	31	analog	analog	NN
cord-022313-2675sjlf	766	32	β	β	NNP
cord-022313-2675sjlf	766	33	-	-	HYPH
cord-022313-2675sjlf	766	34	hydroxynorvaline	hydroxynorvaline	NNP
cord-022313-2675sjlf	766	35	on	on	IN
cord-022313-2675sjlf	766	36	the	the	DT
cord-022313-2675sjlf	766	37	glycosylation	glycosylation	NN
cord-022313-2675sjlf	766	38	and	and	CC
cord-022313-2675sjlf	766	39	secretion	secretion	NN
cord-022313-2675sjlf	766	40	of	of	IN
cord-022313-2675sjlf	766	41	α	α	NN
cord-022313-2675sjlf	766	42	-	-	HYPH
cord-022313-2675sjlf	766	43	acid	acid	NN
cord-022313-2675sjlf	766	44	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	766	45	by	by	IN
cord-022313-2675sjlf	766	46	rat	rat	NN
cord-022313-2675sjlf	766	47	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	766	48	Effect	effect	NN
cord-022313-2675sjlf	766	49	of	of	IN
cord-022313-2675sjlf	766	50	energy	energy	NN
cord-022313-2675sjlf	766	51	depletion	depletion	NN
cord-022313-2675sjlf	766	52	on	on	IN
cord-022313-2675sjlf	766	53	the	the	DT
cord-022313-2675sjlf	766	54	glycosyla	glycosyla	NNP
cord-022313-2675sjlf	766	55	tion	tion	NN
cord-022313-2675sjlf	766	56	of	of	IN
cord-022313-2675sjlf	766	57	viral	viral	JJ
cord-022313-2675sjlf	766	58	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	766	59	Studies	Studies	NNPS
cord-022313-2675sjlf	766	60	on	on	IN
cord-022313-2675sjlf	766	61	the	the	DT
cord-022313-2675sjlf	766	62	regulation	regulation	NN
cord-022313-2675sjlf	766	63	of	of	IN
cord-022313-2675sjlf	766	64	the	the	DT
cord-022313-2675sjlf	766	65	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	766	66	of	of	IN
cord-022313-2675sjlf	766	67	glucose	glucose	NN
cord-022313-2675sjlf	766	68	-	-	HYPH
cord-022313-2675sjlf	766	69	containing	contain	VBG
cord-022313-2675sjlf	766	70	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	766	71	-	-	HYPH
cord-022313-2675sjlf	766	72	lipids	lipid	NNS
cord-022313-2675sjlf	766	73	:	:	:
cord-022313-2675sjlf	766	74	Effects	effect	NNS
cord-022313-2675sjlf	766	75	of	of	IN
cord-022313-2675sjlf	766	76	energy	energy	NN
cord-022313-2675sjlf	766	77	deprivation	deprivation	NN
cord-022313-2675sjlf	767	1	The	the	DT
cord-022313-2675sjlf	767	2	chemistry	chemistry	NN
cord-022313-2675sjlf	767	3	and	and	CC
cord-022313-2675sjlf	767	4	biochemistry	biochemistry	NN
cord-022313-2675sjlf	767	5	of	of	IN
cord-022313-2675sjlf	767	6	simple	simple	JJ
cord-022313-2675sjlf	767	7	indolizidine	indolizidine	NN
cord-022313-2675sjlf	767	8	and	and	CC
cord-022313-2675sjlf	767	9	related	relate	VBN
cord-022313-2675sjlf	767	10	polyhydroxy	polyhydroxy	NN
cord-022313-2675sjlf	767	11	alkaloids	alkaloid	NNS
cord-022313-2675sjlf	767	12	Castanospermine	Castanospermine	NNP
cord-022313-2675sjlf	767	13	,	,	,
cord-022313-2675sjlf	767	14	a	a	DT
cord-022313-2675sjlf	767	15	1,6,7,8-tetrahydroxy	1,6,7,8-tetrahydroxy	CD
cord-022313-2675sjlf	767	16	-	-	HYPH
cord-022313-2675sjlf	767	17	octahydroindolizidine	octahydroindolizidine	NN
cord-022313-2675sjlf	767	18	alka	alka	NNP
cord-022313-2675sjlf	767	19	loid	loid	NNP
cord-022313-2675sjlf	767	20	from	from	IN
cord-022313-2675sjlf	767	21	the	the	DT
cord-022313-2675sjlf	767	22	seeds	seed	NNS
cord-022313-2675sjlf	767	23	of	of	IN
cord-022313-2675sjlf	767	24	Castonospermum	Castonospermum	NNP
cord-022313-2675sjlf	767	25	australe	australe	NNP
cord-022313-2675sjlf	767	26	Castano	Castano	NNP
cord-022313-2675sjlf	767	27	spermine	spermine	NN
cord-022313-2675sjlf	767	28	,	,	,
cord-022313-2675sjlf	767	29	a	a	DT
cord-022313-2675sjlf	767	30	tetrahydroxylated	tetrahydroxylated	JJ
cord-022313-2675sjlf	767	31	alkaloid	alkaloid	NN
cord-022313-2675sjlf	767	32	that	that	WDT
cord-022313-2675sjlf	767	33	inhibits	inhibit	VBZ
cord-022313-2675sjlf	767	34	β	β	NN
cord-022313-2675sjlf	767	35	-	-	HYPH
cord-022313-2675sjlf	767	36	glucosidase	glucosidase	NNP
cord-022313-2675sjlf	767	37	and	and	CC
cord-022313-2675sjlf	767	38	β	β	NN
cord-022313-2675sjlf	767	39	-	-	HYPH
cord-022313-2675sjlf	767	40	glucocerebrosidase	glucocerebrosidase	NN
cord-022313-2675sjlf	767	41	Castanospermine	Castanospermine	NNP
cord-022313-2675sjlf	767	42	inhibits	inhibit	VBZ
cord-022313-2675sjlf	767	43	the	the	DT
cord-022313-2675sjlf	767	44	processing	processing	NN
cord-022313-2675sjlf	767	45	of	of	IN
cord-022313-2675sjlf	767	46	the	the	DT
cord-022313-2675sjlf	767	47	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	767	48	portion	portion	NN
cord-022313-2675sjlf	767	49	of	of	IN
cord-022313-2675sjlf	767	50	the	the	DT
cord-022313-2675sjlf	767	51	influenza	influenza	NN
cord-022313-2675sjlf	767	52	viral	viral	JJ
cord-022313-2675sjlf	767	53	hemagglutinin	hemagglutinin	NN
cord-022313-2675sjlf	768	1	The	the	DT
cord-022313-2675sjlf	768	2	effects	effect	NNS
cord-022313-2675sjlf	768	3	of	of	IN
cord-022313-2675sjlf	768	4	castanospermine	castanospermine	NN
cord-022313-2675sjlf	768	5	and	and	CC
cord-022313-2675sjlf	768	6	swainsonine	swainsonine	NN
cord-022313-2675sjlf	768	7	on	on	IN
cord-022313-2675sjlf	768	8	the	the	DT
cord-022313-2675sjlf	768	9	activity	activity	NN
cord-022313-2675sjlf	768	10	and	and	CC
cord-022313-2675sjlf	768	11	synthesis	synthesis	NN
cord-022313-2675sjlf	768	12	of	of	IN
cord-022313-2675sjlf	768	13	intestinal	intestinal	JJ
cord-022313-2675sjlf	768	14	sucrase	sucrase	NN
cord-022313-2675sjlf	768	15	New	New	NNP
cord-022313-2675sjlf	768	16	enzyme	enzyme	NN
cord-022313-2675sjlf	768	17	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	768	18	from	from	IN
cord-022313-2675sjlf	768	19	microorganisms	microorganism	NNS
cord-022313-2675sjlf	768	20	Glucosidaseinhibition	Glucosidaseinhibition	NNP
cord-022313-2675sjlf	768	21	aus	aus	NNP
cord-022313-2675sjlf	768	22	Bacillus	Bacillus	NNP
cord-022313-2675sjlf	768	23	Inhibition	Inhibition	NNP
cord-022313-2675sjlf	768	24	of	of	IN
cord-022313-2675sjlf	768	25	N	N	NNP
cord-022313-2675sjlf	768	26	-	-	HYPH
cord-022313-2675sjlf	768	27	linked	link	VBN
cord-022313-2675sjlf	768	28	complex	complex	JJ
cord-022313-2675sjlf	768	29	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	768	30	formation	formation	NN
cord-022313-2675sjlf	768	31	by	by	IN
cord-022313-2675sjlf	768	32	1-deoxynojirimycin	1-deoxynojirimycin	CD
cord-022313-2675sjlf	768	33	,	,	,
cord-022313-2675sjlf	768	34	an	an	DT
cord-022313-2675sjlf	768	35	inhibitor	inhibitor	NN
cord-022313-2675sjlf	768	36	of	of	IN
cord-022313-2675sjlf	768	37	processing	process	VBG
cord-022313-2675sjlf	768	38	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	769	1	The	the	DT
cord-022313-2675sjlf	769	2	pyrrolidine	pyrrolidine	JJ
cord-022313-2675sjlf	769	3	alkaloid	alkaloid	NN
cord-022313-2675sjlf	769	4	,	,	,
cord-022313-2675sjlf	769	5	2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine	2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine	CD
cord-022313-2675sjlf	769	6	,	,	,
cord-022313-2675sjlf	769	7	inhibits	inhibit	VBZ
cord-022313-2675sjlf	769	8	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	769	9	processing	process	VBG
cord-022313-2675sjlf	769	10	Glucose	Glucose	NNP
cord-022313-2675sjlf	769	11	removal	removal	NN
cord-022313-2675sjlf	769	12	from	from	IN
cord-022313-2675sjlf	769	13	N	n	NN
cord-022313-2675sjlf	769	14	-	-	HYPH
cord-022313-2675sjlf	769	15	linked	link	VBN
cord-022313-2675sjlf	769	16	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	769	17	is	be	VBZ
cord-022313-2675sjlf	769	18	required	require	VBN
cord-022313-2675sjlf	769	19	for	for	IN
cord-022313-2675sjlf	769	20	efficient	efficient	JJ
cord-022313-2675sjlf	769	21	maturation	maturation	NN
cord-022313-2675sjlf	769	22	of	of	IN
cord-022313-2675sjlf	769	23	certain	certain	JJ
cord-022313-2675sjlf	769	24	secretory	secretory	JJ
cord-022313-2675sjlf	769	25	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	769	26	from	from	IN
cord-022313-2675sjlf	769	27	rough	rough	JJ
cord-022313-2675sjlf	769	28	ER	er	NN
cord-022313-2675sjlf	769	29	to	to	IN
cord-022313-2675sjlf	769	30	Golgi	Golgi	NNP
cord-022313-2675sjlf	769	31	complex	complex	JJ
cord-022313-2675sjlf	769	32	Castanospermine	Castanospermine	NNP
cord-022313-2675sjlf	769	33	inhibits	inhibit	VBZ
cord-022313-2675sjlf	769	34	the	the	DT
cord-022313-2675sjlf	769	35	function	function	NN
cord-022313-2675sjlf	769	36	of	of	IN
cord-022313-2675sjlf	769	37	the	the	DT
cord-022313-2675sjlf	769	38	low	low	JJ
cord-022313-2675sjlf	769	39	density	density	NN
cord-022313-2675sjlf	769	40	lipoprotein	lipoprotein	NN
cord-022313-2675sjlf	769	41	receptor	receptor	NN
cord-022313-2675sjlf	769	42	Effects	effect	NNS
cord-022313-2675sjlf	769	43	of	of	IN
cord-022313-2675sjlf	769	44	castano	castano	NN
cord-022313-2675sjlf	769	45	spermine	spermine	NN
cord-022313-2675sjlf	769	46	and	and	CC
cord-022313-2675sjlf	769	47	1-deoxynojirimycin	1-deoxynojirimycin	CD
cord-022313-2675sjlf	769	48	on	on	IN
cord-022313-2675sjlf	769	49	insulin	insulin	NN
cord-022313-2675sjlf	769	50	receptor	receptor	NN
cord-022313-2675sjlf	769	51	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	770	1	The	the	DT
cord-022313-2675sjlf	770	2	effects	effect	NNS
cord-022313-2675sjlf	770	3	of	of	IN
cord-022313-2675sjlf	770	4	processing	processing	NN
cord-022313-2675sjlf	770	5	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	770	6	of	of	IN
cord-022313-2675sjlf	770	7	N	n	NN
cord-022313-2675sjlf	770	8	-	-	HYPH
cord-022313-2675sjlf	770	9	linked	link	VBN
cord-022313-2675sjlf	770	10	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	770	11	on	on	IN
cord-022313-2675sjlf	770	12	the	the	DT
cord-022313-2675sjlf	770	13	intracellular	intracellular	JJ
cord-022313-2675sjlf	770	14	migration	migration	NN
cord-022313-2675sjlf	770	15	of	of	IN
cord-022313-2675sjlf	770	16	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	770	17	E2	E2	NNP
cord-022313-2675sjlf	770	18	of	of	IN
cord-022313-2675sjlf	770	19	mouse	mouse	NNP
cord-022313-2675sjlf	770	20	hepatitis	hepatitis	NNP
cord-022313-2675sjlf	770	21	virus	virus	NN
cord-022313-2675sjlf	770	22	and	and	CC
cord-022313-2675sjlf	770	23	the	the	DT
cord-022313-2675sjlf	770	24	muturation	muturation	NN
cord-022313-2675sjlf	770	25	of	of	IN
cord-022313-2675sjlf	770	26	coronavirus	coronavirus	NN
cord-022313-2675sjlf	770	27	particles	particle	NNS
cord-022313-2675sjlf	770	28	Palmitylation	Palmitylation	NNP
cord-022313-2675sjlf	770	29	,	,	,
cord-022313-2675sjlf	770	30	sulfation	sulfation	NN
cord-022313-2675sjlf	770	31	,	,	,
cord-022313-2675sjlf	770	32	and	and	CC
cord-022313-2675sjlf	770	33	glycosyla	glycosyla	NNP
cord-022313-2675sjlf	770	34	tion	tion	NN
cord-022313-2675sjlf	770	35	of	of	IN
cord-022313-2675sjlf	770	36	the	the	DT
cord-022313-2675sjlf	770	37	a	a	DT
cord-022313-2675sjlf	770	38	subunit	subunit	NN
cord-022313-2675sjlf	770	39	of	of	IN
cord-022313-2675sjlf	770	40	the	the	DT
cord-022313-2675sjlf	770	41	sodium	sodium	NN
cord-022313-2675sjlf	770	42	channel	channel	NN
cord-022313-2675sjlf	770	43	:	:	:
cord-022313-2675sjlf	771	1	Role	role	NN
cord-022313-2675sjlf	771	2	of	of	IN
cord-022313-2675sjlf	771	3	post	post	JJ
cord-022313-2675sjlf	771	4	-	-	JJ
cord-022313-2675sjlf	771	5	translational	translational	JJ
cord-022313-2675sjlf	771	6	modification	modification	NN
cord-022313-2675sjlf	771	7	in	in	IN
cord-022313-2675sjlf	771	8	channel	channel	NN
cord-022313-2675sjlf	771	9	assembly	assembly	NNP
cord-022313-2675sjlf	771	10	Inhibition	Inhibition	NNP
cord-022313-2675sjlf	771	11	of	of	IN
cord-022313-2675sjlf	771	12	human	human	JJ
cord-022313-2675sjlf	771	13	immunodeficiency	immunodeficiency	NN
cord-022313-2675sjlf	771	14	virus	virus	NN
cord-022313-2675sjlf	771	15	syncytium	syncytium	NNP
cord-022313-2675sjlf	771	16	formation	formation	NN
cord-022313-2675sjlf	771	17	and	and	CC
cord-022313-2675sjlf	771	18	virus	virus	NN
cord-022313-2675sjlf	771	19	replication	replication	NN
cord-022313-2675sjlf	771	20	by	by	IN
cord-022313-2675sjlf	771	21	castano	castano	NNP
cord-022313-2675sjlf	771	22	spermine	spermine	NNP
cord-022313-2675sjlf	771	23	Interference	Interference	NNP
cord-022313-2675sjlf	771	24	with	with	IN
cord-022313-2675sjlf	771	25	HIV	HIV	NNP
cord-022313-2675sjlf	771	26	induced	induce	VBD
cord-022313-2675sjlf	771	27	syncytium	syncytium	NN
cord-022313-2675sjlf	771	28	formation	formation	NN
cord-022313-2675sjlf	771	29	and	and	CC
cord-022313-2675sjlf	771	30	viral	viral	JJ
cord-022313-2675sjlf	771	31	inefectivity	inefectivity	NN
cord-022313-2675sjlf	771	32	by	by	IN
cord-022313-2675sjlf	771	33	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	771	34	of	of	IN
cord-022313-2675sjlf	771	35	trimming	trim	VBG
cord-022313-2675sjlf	771	36	glycosidases	glycosidases	NNP
cord-022313-2675sjlf	771	37	Role	Role	NNP
cord-022313-2675sjlf	771	38	of	of	IN
cord-022313-2675sjlf	771	39	protein	protein	NN
cord-022313-2675sjlf	771	40	N	n	NN
cord-022313-2675sjlf	771	41	-	-	HYPH
cord-022313-2675sjlf	771	42	glycosylation	glycosylation	NN
cord-022313-2675sjlf	771	43	in	in	IN
cord-022313-2675sjlf	771	44	pathogenesis	pathogenesis	NN
cord-022313-2675sjlf	771	45	of	of	IN
cord-022313-2675sjlf	771	46	human	human	JJ
cord-022313-2675sjlf	771	47	immunodeficiency	immunodeficiency	NN
cord-022313-2675sjlf	771	48	virus	virus	NN
cord-022313-2675sjlf	771	49	type	type	NN
cord-022313-2675sjlf	771	50	I	I	NNP
cord-022313-2675sjlf	771	51	Australine	Australine	NNP
cord-022313-2675sjlf	771	52	,	,	,
cord-022313-2675sjlf	771	53	a	a	DT
cord-022313-2675sjlf	771	54	pyrrolizidine	pyrrolizidine	JJ
cord-022313-2675sjlf	771	55	alkaloid	alkaloid	NN
cord-022313-2675sjlf	771	56	that	that	WDT
cord-022313-2675sjlf	771	57	inhibits	inhibit	VBZ
cord-022313-2675sjlf	771	58	amyloglucosidase	amyloglucosidase	NN
cord-022313-2675sjlf	771	59	and	and	CC
cord-022313-2675sjlf	771	60	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	771	61	processing	process	VBG
cord-022313-2675sjlf	771	62	Total	total	JJ
cord-022313-2675sjlf	771	63	synthesis	synthesis	NN
cord-022313-2675sjlf	771	64	of	of	IN
cord-022313-2675sjlf	771	65	2,6-dideoxy-2,6-imino-7	2,6-dideoxy-2,6-imino-7	CD
cord-022313-2675sjlf	771	66	-	-	HYPH
cord-022313-2675sjlf	771	67	0-/3-D	0-/3-d	CD
cord-022313-2675sjlf	771	68	-	-	HYPH
cord-022313-2675sjlf	771	69	glucopyranosy	glucopyranosy	NN
cord-022313-2675sjlf	771	70	-	-	HYPH
cord-022313-2675sjlf	771	71	Dglycero	Dglycero	NNP
cord-022313-2675sjlf	771	72	-	-	HYPH
cord-022313-2675sjlf	771	73	L	L	NNP
cord-022313-2675sjlf	771	74	-	-	HYPH
cord-022313-2675sjlf	771	75	gulo	gulo	NNP
cord-022313-2675sjlf	771	76	-	-	HYPH
cord-022313-2675sjlf	771	77	heptitol	heptitol	NNP
cord-022313-2675sjlf	771	78	hydrochloride	hydrochloride	NN
cord-022313-2675sjlf	771	79	:	:	:
cord-022313-2675sjlf	772	1	A	a	DT
cord-022313-2675sjlf	772	2	potent	potent	JJ
cord-022313-2675sjlf	772	3	inhibitor	inhibitor	NN
cord-022313-2675sjlf	772	4	of	of	IN
cord-022313-2675sjlf	772	5	α	α	NN
cord-022313-2675sjlf	772	6	-	-	HYPH
cord-022313-2675sjlf	772	7	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	772	8	Selective	selective	JJ
cord-022313-2675sjlf	772	9	inhibition	inhibition	NN
cord-022313-2675sjlf	772	10	of	of	IN
cord-022313-2675sjlf	772	11	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	772	12	processing	processing	NN
cord-022313-2675sjlf	772	13	enzymes	enzyme	NNS
cord-022313-2675sjlf	772	14	:	:	:
cord-022313-2675sjlf	772	15	Differential	differential	JJ
cord-022313-2675sjlf	772	16	inhibition	inhibition	NN
cord-022313-2675sjlf	772	17	of	of	IN
cord-022313-2675sjlf	772	18	glucosidases	glucosidase	NNS
cord-022313-2675sjlf	772	19	I	I	NNP
cord-022313-2675sjlf	772	20	and	and	CC
cord-022313-2675sjlf	772	21	II	II	NNP
cord-022313-2675sjlf	772	22	in	in	IN
cord-022313-2675sjlf	772	23	cell	cell	NN
cord-022313-2675sjlf	772	24	culture	culture	NN
cord-022313-2675sjlf	772	25	Swainsonine	Swainsonine	NNP
cord-022313-2675sjlf	772	26	,	,	,
cord-022313-2675sjlf	772	27	an	an	DT
cord-022313-2675sjlf	772	28	inhibitor	inhibitor	NN
cord-022313-2675sjlf	772	29	of	of	IN
cord-022313-2675sjlf	772	30	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	772	31	processing	process	VBG
cord-022313-2675sjlf	772	32	Inhibition	inhibition	NN
cord-022313-2675sjlf	772	33	of	of	IN
cord-022313-2675sjlf	772	34	lysosomal	lysosomal	JJ
cord-022313-2675sjlf	772	35	α	α	NN
cord-022313-2675sjlf	772	36	-	-	HYPH
cord-022313-2675sjlf	772	37	mannosidase	mannosidase	NN
cord-022313-2675sjlf	772	38	by	by	IN
cord-022313-2675sjlf	772	39	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	772	40	,	,	,
cord-022313-2675sjlf	772	41	an	an	DT
cord-022313-2675sjlf	772	42	indolizidine	indolizidine	NN
cord-022313-2675sjlf	772	43	alkaloid	alkaloid	NN
cord-022313-2675sjlf	772	44	isolated	isolate	VBN
cord-022313-2675sjlf	772	45	from	from	IN
cord-022313-2675sjlf	772	46	Swainsona	Swainsona	NNP
cord-022313-2675sjlf	772	47	canescens	canescen	VBZ
cord-022313-2675sjlf	772	48	Swainsonine	Swainsonine	NNP
cord-022313-2675sjlf	772	49	inhibits	inhibit	VBZ
cord-022313-2675sjlf	772	50	the	the	DT
cord-022313-2675sjlf	772	51	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	772	52	of	of	IN
cord-022313-2675sjlf	772	53	complex	complex	JJ
cord-022313-2675sjlf	772	54	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	772	55	by	by	IN
cord-022313-2675sjlf	772	56	inhibition	inhibition	NN
cord-022313-2675sjlf	772	57	of	of	IN
cord-022313-2675sjlf	772	58	Golgi	Golgi	NNP
cord-022313-2675sjlf	772	59	mannosidase	mannosidase	NN
cord-022313-2675sjlf	772	60	II	II	NNP
cord-022313-2675sjlf	772	61	Synthesis	Synthesis	NNP
cord-022313-2675sjlf	772	62	of	of	IN
cord-022313-2675sjlf	772	63	5-amino-5-deoxy	5-amino-5-deoxy	CD
cord-022313-2675sjlf	772	64	-	-	HYPH
cord-022313-2675sjlf	772	65	D	d	NN
cord-022313-2675sjlf	772	66	-	-	HYPH
cord-022313-2675sjlf	772	67	mannopyranose	mannopyranose	NN
cord-022313-2675sjlf	772	68	and	and	CC
cord-022313-2675sjlf	772	69	l,5-dideoxy	l,5-dideoxy	NN
cord-022313-2675sjlf	772	70	-	-	:
cord-022313-2675sjlf	772	71	l,5-imino	l,5-imino	NN
cord-022313-2675sjlf	773	1	-D	-d	NN
cord-022313-2675sjlf	773	2	-	-	HYPH
cord-022313-2675sjlf	773	3	mannitol	mannitol	NN
cord-022313-2675sjlf	773	4	,	,	,
cord-022313-2675sjlf	773	5	and	and	CC
cord-022313-2675sjlf	773	6	inhibition	inhibition	NN
cord-022313-2675sjlf	773	7	of	of	IN
cord-022313-2675sjlf	773	8	α	α	NN
cord-022313-2675sjlf	773	9	and	and	CC
cord-022313-2675sjlf	773	10	β	β	NN
cord-022313-2675sjlf	773	11	-	-	HYPH
cord-022313-2675sjlf	773	12	D	D	NNP
cord-022313-2675sjlf	773	13	-	-	HYPH
cord-022313-2675sjlf	773	14	mannosidases	mannosidases	NNP
cord-022313-2675sjlf	773	15	Novel	Novel	NNP
cord-022313-2675sjlf	773	16	mannosidase	mannosidase	NN
cord-022313-2675sjlf	773	17	inhibitor	inhibitor	NN
cord-022313-2675sjlf	773	18	blocking	block	VBG
cord-022313-2675sjlf	773	19	conversion	conversion	NN
cord-022313-2675sjlf	773	20	of	of	IN
cord-022313-2675sjlf	773	21	high	high	JJ
cord-022313-2675sjlf	773	22	-	-	HYPH
cord-022313-2675sjlf	773	23	mannose	mannose	NN
cord-022313-2675sjlf	773	24	to	to	IN
cord-022313-2675sjlf	773	25	complex	complex	JJ
cord-022313-2675sjlf	773	26	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	774	1	The	the	DT
cord-022313-2675sjlf	774	2	effect	effect	NN
cord-022313-2675sjlf	774	3	of	of	IN
cord-022313-2675sjlf	774	4	deoxymannojirimycin	deoxymannojirimycin	NNS
cord-022313-2675sjlf	774	5	on	on	IN
cord-022313-2675sjlf	774	6	the	the	DT
cord-022313-2675sjlf	774	7	processing	processing	NN
cord-022313-2675sjlf	774	8	of	of	IN
cord-022313-2675sjlf	774	9	influenza	influenza	JJ
cord-022313-2675sjlf	774	10	viral	viral	JJ
cord-022313-2675sjlf	774	11	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	774	12	Secretion	secretion	NN
cord-022313-2675sjlf	774	13	of	of	IN
cord-022313-2675sjlf	774	14	high	high	JJ
cord-022313-2675sjlf	774	15	-	-	HYPH
cord-022313-2675sjlf	774	16	mannose	mannose	NN
cord-022313-2675sjlf	774	17	-	-	HYPH
cord-022313-2675sjlf	774	18	type	type	NN
cord-022313-2675sjlf	774	19	a	a	DT
cord-022313-2675sjlf	774	20	r	r	NN
cord-022313-2675sjlf	774	21	proteinase	proteinase	NN
cord-022313-2675sjlf	774	22	inhibitor	inhibitor	NN
cord-022313-2675sjlf	774	23	and	and	CC
cord-022313-2675sjlf	774	24	a	a	DT
cord-022313-2675sjlf	774	25	r	r	NN
cord-022313-2675sjlf	774	26	acid	acid	NN
cord-022313-2675sjlf	774	27	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	774	28	by	by	IN
cord-022313-2675sjlf	774	29	primary	primary	JJ
cord-022313-2675sjlf	774	30	cultures	culture	NNS
cord-022313-2675sjlf	774	31	of	of	IN
cord-022313-2675sjlf	774	32	rat	rat	NN
cord-022313-2675sjlf	774	33	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	774	34	in	in	IN
cord-022313-2675sjlf	774	35	the	the	DT
cord-022313-2675sjlf	774	36	presence	presence	NN
cord-022313-2675sjlf	774	37	of	of	IN
cord-022313-2675sjlf	774	38	the	the	DT
cord-022313-2675sjlf	774	39	mannosidase	mannosidase	NN
cord-022313-2675sjlf	774	40	inhibitor	inhibitor	NN
cord-022313-2675sjlf	774	41	Membrane	Membrane	NNP
cord-022313-2675sjlf	774	42	traffic	traffic	NN
cord-022313-2675sjlf	774	43	in	in	IN
cord-022313-2675sjlf	774	44	animal	animal	NN
cord-022313-2675sjlf	774	45	cells	cell	NNS
cord-022313-2675sjlf	774	46	:	:	:
cord-022313-2675sjlf	775	1	Cellular	cellular	JJ
cord-022313-2675sjlf	775	2	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	775	3	return	return	VBP
cord-022313-2675sjlf	775	4	to	to	IN
cord-022313-2675sjlf	775	5	the	the	DT
cord-022313-2675sjlf	775	6	site	site	NN
cord-022313-2675sjlf	775	7	of	of	IN
cord-022313-2675sjlf	775	8	Golgi	Golgi	NNP
cord-022313-2675sjlf	775	9	mannosidase	mannosidase	NN
cord-022313-2675sjlf	776	1	I	-PRON-	PRP
cord-022313-2675sjlf	777	1	The	the	DT
cord-022313-2675sjlf	777	2	use	use	NN
cord-022313-2675sjlf	777	3	of	of	IN
cord-022313-2675sjlf	777	4	1-deoxymannojirimycin	1-deoxymannojirimycin	CD
cord-022313-2675sjlf	777	5	to	to	TO
cord-022313-2675sjlf	777	6	evaluate	evaluate	VB
cord-022313-2675sjlf	777	7	the	the	DT
cord-022313-2675sjlf	777	8	role	role	NN
cord-022313-2675sjlf	777	9	of	of	IN
cord-022313-2675sjlf	777	10	various	various	JJ
cord-022313-2675sjlf	777	11	α	α	NN
cord-022313-2675sjlf	777	12	-	-	HYPH
cord-022313-2675sjlf	777	13	mannosidases	mannosidase	NNS
cord-022313-2675sjlf	777	14	in	in	IN
cord-022313-2675sjlf	777	15	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	777	16	processing	processing	NN
cord-022313-2675sjlf	777	17	in	in	IN
cord-022313-2675sjlf	777	18	intact	intact	JJ
cord-022313-2675sjlf	777	19	cells	cell	NNS
cord-022313-2675sjlf	777	20	Design	design	NN
cord-022313-2675sjlf	777	21	,	,	,
cord-022313-2675sjlf	777	22	synthesis	synthesis	NN
cord-022313-2675sjlf	777	23	and	and	CC
cord-022313-2675sjlf	777	24	preliminary	preliminary	JJ
cord-022313-2675sjlf	777	25	evaluation	evaluation	NN
cord-022313-2675sjlf	777	26	of	of	IN
cord-022313-2675sjlf	777	27	a	a	DT
cord-022313-2675sjlf	777	28	potent	potent	JJ
cord-022313-2675sjlf	777	29	α	α	NN
cord-022313-2675sjlf	777	30	-	-	HYPH
cord-022313-2675sjlf	777	31	mannosidase	mannosidase	NN
cord-022313-2675sjlf	777	32	inhibitor	inhibitor	NN
cord-022313-2675sjlf	777	33	,	,	,
cord-022313-2675sjlf	777	34	1,4-dideoxy	1,4-dideoxy	CD
cord-022313-2675sjlf	777	35	-	-	HYPH
cord-022313-2675sjlf	777	36	l,4-imino	l,4-imino	NN
cord-022313-2675sjlf	777	37	-	-	HYPH
cord-022313-2675sjlf	777	38	D	d	NN
cord-022313-2675sjlf	777	39	-	-	HYPH
cord-022313-2675sjlf	777	40	mannitol	mannitol	NN
cord-022313-2675sjlf	778	1	l,4-Dideoxy	l,4-dideoxy	JJ
cord-022313-2675sjlf	778	2	-	-	HYPH
cord-022313-2675sjlf	778	3	l,4-imino	l,4-imino	NNP
cord-022313-2675sjlf	778	4	-	-	HYPH
cord-022313-2675sjlf	778	5	D	d	NN
cord-022313-2675sjlf	778	6	-	-	HYPH
cord-022313-2675sjlf	778	7	mannitol	mannitol	NN
cord-022313-2675sjlf	778	8	inhibits	inhibit	VBZ
cord-022313-2675sjlf	778	9	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	778	10	processing	process	VBG
cord-022313-2675sjlf	778	11	Structure	Structure	NNP
cord-022313-2675sjlf	778	12	of	of	IN
cord-022313-2675sjlf	778	13	kifunensine	kifunensine	NNP
cord-022313-2675sjlf	778	14	,	,	,
cord-022313-2675sjlf	778	15	a	a	DT
cord-022313-2675sjlf	778	16	new	new	JJ
cord-022313-2675sjlf	778	17	immunomodulator	immunomodulator	NN
cord-022313-2675sjlf	778	18	isolated	isolate	VBN
cord-022313-2675sjlf	778	19	from	from	IN
cord-022313-2675sjlf	778	20	an	an	DT
cord-022313-2675sjlf	778	21	actinomycete	actinomycete	JJ
cord-022313-2675sjlf	778	22	Kifunensine	Kifunensine	NNP
cord-022313-2675sjlf	778	23	,	,	,
cord-022313-2675sjlf	778	24	a	a	DT
cord-022313-2675sjlf	778	25	potent	potent	JJ
cord-022313-2675sjlf	778	26	inhibitor	inhibitor	NN
cord-022313-2675sjlf	778	27	of	of	IN
cord-022313-2675sjlf	778	28	the	the	DT
cord-022313-2675sjlf	778	29	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	778	30	processing	processing	NN
cord-022313-2675sjlf	778	31	mannosidase	mannosidase	NN
cord-022313-2675sjlf	778	32	I	-PRON-	PRP
cord-022313-2675sjlf	778	33	Mimicking	mimic	VBG
cord-022313-2675sjlf	778	34	the	the	DT
cord-022313-2675sjlf	778	35	glucosidase	glucosidase	NN
cord-022313-2675sjlf	778	36	transition	transition	NN
cord-022313-2675sjlf	778	37	state	state	NN
cord-022313-2675sjlf	778	38	:	:	:
cord-022313-2675sjlf	778	39	Shape	shape	NN
cord-022313-2675sjlf	778	40	/	/	SYM
cord-022313-2675sjlf	778	41	charge	charge	NN
cord-022313-2675sjlf	778	42	considerations	consideration	NNS
cord-022313-2675sjlf	779	1	A	a	DT
cord-022313-2675sjlf	779	2	spectrophotometric	spectrophotometric	JJ
cord-022313-2675sjlf	779	3	investigation	investigation	NN
cord-022313-2675sjlf	779	4	of	of	IN
cord-022313-2675sjlf	779	5	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	779	6	,	,	,
cord-022313-2675sjlf	779	7	an	an	DT
cord-022313-2675sjlf	779	8	α	α	NN
cord-022313-2675sjlf	779	9	-	-	HYPH
cord-022313-2675sjlf	779	10	mannosidase	mannosidase	NN
cord-022313-2675sjlf	779	11	inhibitor	inhibitor	NN
cord-022313-2675sjlf	779	12	isolated	isolate	VBN
cord-022313-2675sjlf	779	13	from	from	IN
cord-022313-2675sjlf	779	14	Swainsona	Swainsona	NNP
cord-022313-2675sjlf	779	15	canescens	canescens	POS
cord-022313-2675sjlf	779	16	Loco	Loco	NNP
cord-022313-2675sjlf	779	17	intoxication	intoxication	NN
cord-022313-2675sjlf	779	18	:	:	:
cord-022313-2675sjlf	780	1	Indolizidine	Indolizidine	NNP
cord-022313-2675sjlf	780	2	alkaloids	alkaloid	NNS
cord-022313-2675sjlf	780	3	of	of	IN
cord-022313-2675sjlf	780	4	spotted	spot	VBN
cord-022313-2675sjlf	780	5	locoweed	locoweed	NN
cord-022313-2675sjlf	780	6	(	(	-LRB-
cord-022313-2675sjlf	780	7	Astragalus	Astragalus	NNP
cord-022313-2675sjlf	780	8	lentiginosus	lentiginosus	NN
cord-022313-2675sjlf	780	9	)	)	-RRB-
cord-022313-2675sjlf	780	10	Isolation	isolation	NN
cord-022313-2675sjlf	780	11	and	and	CC
cord-022313-2675sjlf	780	12	characterization	characterization	NN
cord-022313-2675sjlf	780	13	of	of	IN
cord-022313-2675sjlf	780	14	swainsonine	swainsonine	NN
cord-022313-2675sjlf	780	15	from	from	IN
cord-022313-2675sjlf	780	16	Texas	Texas	NNP
cord-022313-2675sjlf	780	17	locoweed	locoweed	NN
cord-022313-2675sjlf	780	18	(	(	-LRB-
cord-022313-2675sjlf	780	19	Astragalus	Astragalus	NNP
cord-022313-2675sjlf	780	20	mollisimus	mollisimus	NN
cord-022313-2675sjlf	780	21	)	)	-RRB-
cord-022313-2675sjlf	781	1	The	the	DT
cord-022313-2675sjlf	781	2	indolizidine	indolizidine	NN
cord-022313-2675sjlf	781	3	alkaloids	alkaloid	NNS
cord-022313-2675sjlf	781	4	,	,	,
cord-022313-2675sjlf	781	5	slaframine	slaframine	NN
cord-022313-2675sjlf	781	6	and	and	CC
cord-022313-2675sjlf	781	7	swainsonine	swainsonine	NN
cord-022313-2675sjlf	781	8	:	:	:
cord-022313-2675sjlf	782	1	Con	con	NN
cord-022313-2675sjlf	782	2	taminants	taminant	NNS
cord-022313-2675sjlf	782	3	in	in	IN
cord-022313-2675sjlf	782	4	animal	animal	NN
cord-022313-2675sjlf	782	5	forages	forage	NNS
cord-022313-2675sjlf	782	6	Lysosomal	Lysosomal	NNP
cord-022313-2675sjlf	782	7	storage	storage	NN
cord-022313-2675sjlf	782	8	in	in	IN
cord-022313-2675sjlf	782	9	Swainsona	Swainsona	NNP
cord-022313-2675sjlf	782	10	spp	spp	NNS
cord-022313-2675sjlf	782	11	.	.	.
cord-022313-2675sjlf	783	1	toxicosis	toxicosis	NN
cord-022313-2675sjlf	783	2	:	:	:
cord-022313-2675sjlf	784	1	An	an	DT
cord-022313-2675sjlf	784	2	induced	induce	VBN
cord-022313-2675sjlf	784	3	mannosidosis	mannosidosis	NN
cord-022313-2675sjlf	785	1	The	the	DT
cord-022313-2675sjlf	785	2	similar	similar	JJ
cord-022313-2675sjlf	785	3	effects	effect	NNS
cord-022313-2675sjlf	785	4	of	of	IN
cord-022313-2675sjlf	785	5	swainsonine	swainsonine	NN
cord-022313-2675sjlf	785	6	and	and	CC
cord-022313-2675sjlf	785	7	locoweed	locowee	VBD
cord-022313-2675sjlf	785	8	on	on	IN
cord-022313-2675sjlf	785	9	tissue	tissue	NN
cord-022313-2675sjlf	785	10	glycosidases	glycosidase	NNS
cord-022313-2675sjlf	785	11	and	and	CC
cord-022313-2675sjlf	785	12	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	785	13	of	of	IN
cord-022313-2675sjlf	785	14	the	the	DT
cord-022313-2675sjlf	785	15	pig	pig	NN
cord-022313-2675sjlf	785	16	indicate	indicate	VBP
cord-022313-2675sjlf	785	17	the	the	DT
cord-022313-2675sjlf	785	18	alkaloid	alkaloid	NN
cord-022313-2675sjlf	785	19	is	be	VBZ
cord-022313-2675sjlf	785	20	the	the	DT
cord-022313-2675sjlf	785	21	principle	principle	JJ
cord-022313-2675sjlf	785	22	toxin	toxin	NN
cord-022313-2675sjlf	785	23	responsible	responsible	JJ
cord-022313-2675sjlf	785	24	for	for	IN
cord-022313-2675sjlf	785	25	the	the	DT
cord-022313-2675sjlf	785	26	induction	induction	NN
cord-022313-2675sjlf	785	27	of	of	IN
cord-022313-2675sjlf	785	28	locoism	locoism	NNP
cord-022313-2675sjlf	785	29	Induced	induce	VBN
cord-022313-2675sjlf	785	30	mannosidosis	mannosidosis	NN
cord-022313-2675sjlf	785	31	-	-	HYPH
cord-022313-2675sjlf	785	32	excretion	excretion	NN
cord-022313-2675sjlf	785	33	of	of	IN
cord-022313-2675sjlf	785	34	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	785	35	by	by	IN
cord-022313-2675sjlf	785	36	locoweed	locoweed	NN
cord-022313-2675sjlf	785	37	-	-	HYPH
cord-022313-2675sjlf	785	38	intoxicated	intoxicate	VBN
cord-022313-2675sjlf	785	39	sheep	sheep	NN
cord-022313-2675sjlf	785	40	Swainsonine	Swainsonine	NNP
cord-022313-2675sjlf	785	41	affects	affect	VBZ
cord-022313-2675sjlf	785	42	the	the	DT
cord-022313-2675sjlf	785	43	processing	processing	NN
cord-022313-2675sjlf	785	44	of	of	IN
cord-022313-2675sjlf	785	45	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	785	46	in	in	IN
cord-022313-2675sjlf	785	47	vivo	vivo	NNP
cord-022313-2675sjlf	785	48	Swainsonine	Swainsonine	NNP
cord-022313-2675sjlf	785	49	prevents	prevent	VBZ
cord-022313-2675sjlf	785	50	the	the	DT
cord-022313-2675sjlf	785	51	processing	processing	NN
cord-022313-2675sjlf	785	52	of	of	IN
cord-022313-2675sjlf	785	53	the	the	DT
cord-022313-2675sjlf	785	54	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	785	55	chains	chain	NNS
cord-022313-2675sjlf	785	56	of	of	IN
cord-022313-2675sjlf	785	57	the	the	DT
cord-022313-2675sjlf	785	58	influenza	influenza	NN
cord-022313-2675sjlf	785	59	viral	viral	JJ
cord-022313-2675sjlf	785	60	hemag	hemag	NNP
cord-022313-2675sjlf	785	61	glutinin	glutinin	NNP
cord-022313-2675sjlf	785	62	Alteration	Alteration	NNP
cord-022313-2675sjlf	785	63	in	in	IN
cord-022313-2675sjlf	785	64	oligosaccharide	oligosaccharide	JJ
cord-022313-2675sjlf	785	65	structure	structure	NN
cord-022313-2675sjlf	785	66	of	of	IN
cord-022313-2675sjlf	785	67	VSV	VSV	NNP
cord-022313-2675sjlf	785	68	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	785	69	by	by	IN
cord-022313-2675sjlf	785	70	swainsonine	swainsonine	JJ
cord-022313-2675sjlf	785	71	Abnormal	abnormal	JJ
cord-022313-2675sjlf	785	72	glycosylation	glycosylation	NN
cord-022313-2675sjlf	785	73	of	of	IN
cord-022313-2675sjlf	785	74	human	human	JJ
cord-022313-2675sjlf	785	75	cellular	cellular	JJ
cord-022313-2675sjlf	785	76	fibronectin	fibronectin	NN
cord-022313-2675sjlf	785	77	in	in	IN
cord-022313-2675sjlf	785	78	the	the	DT
cord-022313-2675sjlf	785	79	presence	presence	NN
cord-022313-2675sjlf	785	80	of	of	IN
cord-022313-2675sjlf	785	81	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	785	82	Properties	Properties	NNP
cord-022313-2675sjlf	785	83	of	of	IN
cord-022313-2675sjlf	785	84	BHK	BHK	NNP
cord-022313-2675sjlf	785	85	cells	cell	NNS
cord-022313-2675sjlf	785	86	treated	treat	VBN
cord-022313-2675sjlf	785	87	with	with	IN
cord-022313-2675sjlf	785	88	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	785	89	,	,	,
cord-022313-2675sjlf	785	90	an	an	DT
cord-022313-2675sjlf	785	91	inhibitor	inhibitor	NN
cord-022313-2675sjlf	785	92	of	of	IN
cord-022313-2675sjlf	785	93	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	785	94	synthesis	synthesis	NN
cord-022313-2675sjlf	785	95	Inhibition	inhibition	NN
cord-022313-2675sjlf	785	96	of	of	IN
cord-022313-2675sjlf	785	97	Nlinked	Nlinked	NNP
cord-022313-2675sjlf	785	98	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	785	99	processing	processing	NN
cord-022313-2675sjlf	785	100	does	do	VBZ
cord-022313-2675sjlf	785	101	not	not	RB
cord-022313-2675sjlf	785	102	prevent	prevent	VB
cord-022313-2675sjlf	785	103	the	the	DT
cord-022313-2675sjlf	785	104	secretion	secretion	NN
cord-022313-2675sjlf	785	105	of	of	IN
cord-022313-2675sjlf	785	106	thyroglobulin	thyroglobulin	NNP
cord-022313-2675sjlf	785	107	Glycosylation	Glycosylation	NNP
cord-022313-2675sjlf	785	108	and	and	CC
cord-022313-2675sjlf	785	109	secretion	secretion	NN
cord-022313-2675sjlf	785	110	of	of	IN
cord-022313-2675sjlf	785	111	surfactant	surfactant	NN
cord-022313-2675sjlf	785	112	associated	associate	VBD
cord-022313-2675sjlf	785	113	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	785	114	A	a	DT
cord-022313-2675sjlf	785	115	N	n	NN
cord-022313-2675sjlf	785	116	-	-	HYPH
cord-022313-2675sjlf	785	117	linked	link	VBN
cord-022313-2675sjlf	785	118	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	785	119	of	of	IN
cord-022313-2675sjlf	785	120	the	the	DT
cord-022313-2675sjlf	785	121	H-2D	H-2D	NNP
cord-022313-2675sjlf	785	122	k	k	NNP
cord-022313-2675sjlf	785	123	histocom	histocom	NNP
cord-022313-2675sjlf	785	124	patibility	patibility	NNP
cord-022313-2675sjlf	785	125	protein	protein	NNP
cord-022313-2675sjlf	785	126	heavy	heavy	JJ
cord-022313-2675sjlf	785	127	chain	chain	NN
cord-022313-2675sjlf	785	128	influence	influence	NN
cord-022313-2675sjlf	786	1	its	-PRON-	PRP$
cord-022313-2675sjlf	786	2	transport	transport	NN
cord-022313-2675sjlf	786	3	and	and	CC
cord-022313-2675sjlf	786	4	cellular	cellular	JJ
cord-022313-2675sjlf	786	5	distribution	distribution	NN
cord-022313-2675sjlf	786	6	Inhibition	inhibition	NN
cord-022313-2675sjlf	786	7	of	of	IN
cord-022313-2675sjlf	786	8	disulfide	disulfide	JJ
cord-022313-2675sjlf	786	9	bonding	bonding	NN
cord-022313-2675sjlf	786	10	of	of	IN
cord-022313-2675sjlf	786	11	Von	Von	NNP
cord-022313-2675sjlf	786	12	Willebrand	Willebrand	NNP
cord-022313-2675sjlf	786	13	protein	protein	NN
cord-022313-2675sjlf	786	14	by	by	IN
cord-022313-2675sjlf	786	15	monensin	monensin	NNP
cord-022313-2675sjlf	786	16	results	result	NNS
cord-022313-2675sjlf	786	17	in	in	IN
cord-022313-2675sjlf	786	18	small	small	JJ
cord-022313-2675sjlf	786	19	,	,	,
cord-022313-2675sjlf	786	20	functionally	functionally	RB
cord-022313-2675sjlf	786	21	defective	defective	JJ
cord-022313-2675sjlf	786	22	multimers	multimer	NNS
cord-022313-2675sjlf	786	23	Complete	complete	JJ
cord-022313-2675sjlf	786	24	glycosylation	glycosylation	NN
cord-022313-2675sjlf	786	25	of	of	IN
cord-022313-2675sjlf	786	26	the	the	DT
cord-022313-2675sjlf	786	27	insulin	insulin	NN
cord-022313-2675sjlf	786	28	and	and	CC
cord-022313-2675sjlf	786	29	insulin	insulin	NN
cord-022313-2675sjlf	786	30	-	-	HYPH
cord-022313-2675sjlf	786	31	like	like	JJ
cord-022313-2675sjlf	786	32	growth	growth	NN
cord-022313-2675sjlf	786	33	factor	factor	NN
cord-022313-2675sjlf	786	34	I	-PRON-	PRP
cord-022313-2675sjlf	786	35	receptors	receptor	NNS
cord-022313-2675sjlf	786	36	is	be	VBZ
cord-022313-2675sjlf	786	37	not	not	RB
cord-022313-2675sjlf	786	38	necessary	necessary	JJ
cord-022313-2675sjlf	786	39	for	for	IN
cord-022313-2675sjlf	786	40	their	-PRON-	PRP$
cord-022313-2675sjlf	786	41	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	786	42	and	and	CC
cord-022313-2675sjlf	786	43	function	function	VB
cord-022313-2675sjlf	786	44	Glycosylation	Glycosylation	NNP
cord-022313-2675sjlf	786	45	of	of	IN
cord-022313-2675sjlf	786	46	the	the	DT
cord-022313-2675sjlf	786	47	epidermal	epidermal	JJ
cord-022313-2675sjlf	786	48	growth	growth	NN
cord-022313-2675sjlf	786	49	factor	factor	NN
cord-022313-2675sjlf	786	50	receptor	receptor	NN
cord-022313-2675sjlf	786	51	in	in	IN
cord-022313-2675sjlf	786	52	A-431	a-431	NN
cord-022313-2675sjlf	786	53	cells	cell	NNS
cord-022313-2675sjlf	786	54	Influence	influence	NN
cord-022313-2675sjlf	786	55	of	of	IN
cord-022313-2675sjlf	786	56	the	the	DT
cord-022313-2675sjlf	786	57	N	n	NN
cord-022313-2675sjlf	786	58	-	-	HYPH
cord-022313-2675sjlf	786	59	linked	link	VBN
cord-022313-2675sjlf	786	60	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	786	61	on	on	IN
cord-022313-2675sjlf	786	62	the	the	DT
cord-022313-2675sjlf	786	63	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	786	64	,	,	,
cord-022313-2675sjlf	786	65	intracellular	intracellular	JJ
cord-022313-2675sjlf	786	66	routing	routing	NN
cord-022313-2675sjlf	786	67	and	and	CC
cord-022313-2675sjlf	786	68	function	function	NN
cord-022313-2675sjlf	786	69	of	of	IN
cord-022313-2675sjlf	786	70	the	the	DT
cord-022313-2675sjlf	786	71	hu	hu	NNP
cord-022313-2675sjlf	786	72	man	man	NNP
cord-022313-2675sjlf	786	73	asialglycoprotein	asialglycoprotein	NNP
cord-022313-2675sjlf	786	74	receptor	receptor	NN
cord-022313-2675sjlf	786	75	Swainsonine	Swainsonine	NNP
cord-022313-2675sjlf	786	76	and	and	CC
cord-022313-2675sjlf	786	77	Castanosper	Castanosper	NNP
cord-022313-2675sjlf	786	78	mine	mine	NN
cord-022313-2675sjlf	786	79	blockade	blockade	NN
cord-022313-2675sjlf	786	80	of	of	IN
cord-022313-2675sjlf	786	81	mannose	mannose	NN
cord-022313-2675sjlf	786	82	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	786	83	uptake	uptake	NN
cord-022313-2675sjlf	786	84	by	by	IN
cord-022313-2675sjlf	786	85	macrophages	macrophage	NNS
cord-022313-2675sjlf	786	86	The	the	DT
cord-022313-2675sjlf	786	87	effect	effect	NN
cord-022313-2675sjlf	786	88	of	of	IN
cord-022313-2675sjlf	786	89	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	786	90	processing	process	VBG
cord-022313-2675sjlf	786	91	inhibi	inhibi	NNP
cord-022313-2675sjlf	786	92	tors	tor	NNS
cord-022313-2675sjlf	786	93	on	on	IN
cord-022313-2675sjlf	786	94	fucosylation	fucosylation	NN
cord-022313-2675sjlf	786	95	of	of	IN
cord-022313-2675sjlf	786	96	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	786	97	Effects	effect	NNS
cord-022313-2675sjlf	786	98	of	of	IN
cord-022313-2675sjlf	786	99	swainsonine	swainsonine	NNP
cord-022313-2675sjlf	786	100	and	and	CC
cord-022313-2675sjlf	786	101	casta	casta	NNP
cord-022313-2675sjlf	786	102	nospermine	nospermine	NNP
cord-022313-2675sjlf	786	103	upon	upon	IN
cord-022313-2675sjlf	786	104	processing	processing	NN
cord-022313-2675sjlf	786	105	of	of	IN
cord-022313-2675sjlf	786	106	influenza	influenza	NN
cord-022313-2675sjlf	786	107	virus	virus	NN
cord-022313-2675sjlf	786	108	sulfated	sulfate	VBN
cord-022313-2675sjlf	786	109	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	786	110	Glucocorticoids	Glucocorticoids	NNP
cord-022313-2675sjlf	786	111	modulate	modulate	VBP
cord-022313-2675sjlf	786	112	macrophage	macrophage	NN
cord-022313-2675sjlf	786	113	surface	surface	NN
cord-022313-2675sjlf	786	114	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	786	115	and	and	CC
cord-022313-2675sjlf	786	116	their	-PRON-	PRP$
cord-022313-2675sjlf	786	117	binding	binding	NN
cord-022313-2675sjlf	786	118	activity	activity	NN
cord-022313-2675sjlf	787	1	The	the	DT
cord-022313-2675sjlf	787	2	effect	effect	NN
cord-022313-2675sjlf	787	3	of	of	IN
cord-022313-2675sjlf	787	4	swainsonine	swainsonine	NN
cord-022313-2675sjlf	787	5	on	on	IN
cord-022313-2675sjlf	787	6	the	the	DT
cord-022313-2675sjlf	787	7	associa	associa	NNP
cord-022313-2675sjlf	787	8	tion	tion	NN
cord-022313-2675sjlf	787	9	of	of	IN
cord-022313-2675sjlf	787	10	Trypanosoma	Trypanosoma	NNP
cord-022313-2675sjlf	787	11	cruzi	cruzi	NNP
cord-022313-2675sjlf	787	12	with	with	IN
cord-022313-2675sjlf	787	13	host	host	NN
cord-022313-2675sjlf	787	14	cells	cell	NNS
cord-022313-2675sjlf	788	1	Oligosaccha	Oligosaccha	NNP
cord-022313-2675sjlf	788	2	ride	ride	NN
cord-022313-2675sjlf	789	1	modification	modification	NN
cord-022313-2675sjlf	789	2	by	by	IN
cord-022313-2675sjlf	789	3	swainsonine	swainsonine	JJ
cord-022313-2675sjlf	789	4	treatment	treatment	NN
cord-022313-2675sjlf	789	5	inhibits	inhibit	VBZ
cord-022313-2675sjlf	789	6	pulmonary	pulmonary	JJ
cord-022313-2675sjlf	789	7	colonization	colonization	NN
cord-022313-2675sjlf	789	8	by	by	IN
cord-022313-2675sjlf	789	9	B16F10	b16f10	JJ
cord-022313-2675sjlf	789	10	murine	murine	JJ
cord-022313-2675sjlf	789	11	melanoma	melanoma	NN
cord-022313-2675sjlf	789	12	cells	cell	NNS
cord-022313-2675sjlf	789	13	Studies	study	NNS
cord-022313-2675sjlf	789	14	of	of	IN
cord-022313-2675sjlf	789	15	immunomodulator	immunomodulator	NNP
cord-022313-2675sjlf	789	16	Inhibition	Inhibition	NNP
cord-022313-2675sjlf	789	17	by	by	IN
cord-022313-2675sjlf	789	18	swainsonine	swainsonine	NN
cord-022313-2675sjlf	789	19	of	of	IN
cord-022313-2675sjlf	789	20	the	the	DT
cord-022313-2675sjlf	789	21	degradation	degradation	NN
cord-022313-2675sjlf	789	22	of	of	IN
cord-022313-2675sjlf	789	23	endocytosed	endocytose	VBN
cord-022313-2675sjlf	789	24	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	789	25	in	in	IN
cord-022313-2675sjlf	789	26	isolated	isolate	VBN
cord-022313-2675sjlf	789	27	rat	rat	NN
cord-022313-2675sjlf	789	28	liver	liver	NN
cord-022313-2675sjlf	789	29	parenchymal	parenchymal	NN
cord-022313-2675sjlf	789	30	cells	cell	NNS
cord-022313-2675sjlf	789	31	Mannostatins	Mannostatins	NNP
cord-022313-2675sjlf	789	32	A	A	NNP
cord-022313-2675sjlf	789	33	&	&	CC
cord-022313-2675sjlf	789	34	B	b	NN
cord-022313-2675sjlf	789	35	:	:	:
cord-022313-2675sjlf	789	36	New	new	JJ
cord-022313-2675sjlf	789	37	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	789	38	of	of	IN
cord-022313-2675sjlf	789	39	a	a	DT
cord-022313-2675sjlf	789	40	-	-	HYPH
cord-022313-2675sjlf	789	41	D	d	NN
cord-022313-2675sjlf	789	42	-	-	HYPH
cord-022313-2675sjlf	789	43	mannosidase	mannosidase	NN
cord-022313-2675sjlf	789	44	,	,	,
cord-022313-2675sjlf	789	45	produced	produce	VBN
cord-022313-2675sjlf	789	46	by	by	IN
cord-022313-2675sjlf	789	47	Streptoverticillium	Streptoverticillium	NNP
cord-022313-2675sjlf	789	48	verticillus	verticillus	NNP
cord-022313-2675sjlf	789	49	var	var	NN
cord-022313-2675sjlf	789	50	,	,	,
cord-022313-2675sjlf	789	51	quintum	quintum	NNP
cord-022313-2675sjlf	789	52	Mannostatin	Mannostatin	NNP
cord-022313-2675sjlf	789	53	A	A	NNP
cord-022313-2675sjlf	789	54	,	,	,
cord-022313-2675sjlf	789	55	a	a	DT
cord-022313-2675sjlf	789	56	new	new	JJ
cord-022313-2675sjlf	789	57	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	789	58	-	-	HYPH
cord-022313-2675sjlf	789	59	processing	process	VBG
cord-022313-2675sjlf	789	60	inhibitor	inhibitor	NN
cord-022313-2675sjlf	789	61	Amino	amino	NN
cord-022313-2675sjlf	789	62	-	-	HYPH
cord-022313-2675sjlf	789	63	sugar	sugar	NN
cord-022313-2675sjlf	789	64	glycosidase	glycosidase	NN
cord-022313-2675sjlf	789	65	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	789	66	:	:	:
cord-022313-2675sjlf	790	1	Versitile	Versitile	NNP
cord-022313-2675sjlf	790	2	tools	tool	NNS
cord-022313-2675sjlf	790	3	for	for	IN
cord-022313-2675sjlf	790	4	glycobiologists	glycobiologists	NNP
cord-022313-2675sjlf	790	5	Design	Design	NNP
cord-022313-2675sjlf	790	6	of	of	IN
cord-022313-2675sjlf	790	7	potential	potential	JJ
cord-022313-2675sjlf	790	8	anti	anti	JJ
cord-022313-2675sjlf	790	9	-	-	JJ
cord-022313-2675sjlf	790	10	HIV	hiv	JJ
cord-022313-2675sjlf	790	11	agents	agent	NNS
cord-022313-2675sjlf	790	12	:	:	:
cord-022313-2675sjlf	791	1	Mannosi	Mannosi	NNP
cord-022313-2675sjlf	791	2	dase	dase	NNP
cord-022313-2675sjlf	791	3	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	791	4	Lipid	lipid	NN
cord-022313-2675sjlf	791	5	-	-	HYPH
cord-022313-2675sjlf	791	6	saccharide	saccharide	NN
cord-022313-2675sjlf	791	7	intermediates	intermediate	NNS
cord-022313-2675sjlf	791	8	in	in	IN
cord-022313-2675sjlf	791	9	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	791	10	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	791	11	.	.	.
cord-022313-2675sjlf	792	1	I.	I.	NNP
cord-022313-2675sjlf	792	2	Formation	Formation	NNP
cord-022313-2675sjlf	792	3	of	of	IN
cord-022313-2675sjlf	792	4	an	an	DT
cord-022313-2675sjlf	792	5	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	792	6	-	-	HYPH
cord-022313-2675sjlf	792	7	lipid	lipid	NN
cord-022313-2675sjlf	792	8	by	by	IN
cord-022313-2675sjlf	792	9	thyroid	thyroid	NN
cord-022313-2675sjlf	792	10	slices	slice	NNS
cord-022313-2675sjlf	792	11	and	and	CC
cord-022313-2675sjlf	792	12	evaluation	evaluation	NN
cord-022313-2675sjlf	792	13	of	of	IN
cord-022313-2675sjlf	792	14	its	-PRON-	PRP$
cord-022313-2675sjlf	792	15	role	role	NN
cord-022313-2675sjlf	792	16	in	in	IN
cord-022313-2675sjlf	792	17	protein	protein	NN
cord-022313-2675sjlf	792	18	glycosylation	glycosylation	NN
cord-022313-2675sjlf	792	19	Control	Control	NNP
cord-022313-2675sjlf	792	20	of	of	IN
cord-022313-2675sjlf	792	21	N	N	NNP
cord-022313-2675sjlf	792	22	-	-	HYPH
cord-022313-2675sjlf	792	23	linked	link	VBN
cord-022313-2675sjlf	792	24	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	792	25	synthesis	synthesis	NN
cord-022313-2675sjlf	792	26	:	:	:
cord-022313-2675sjlf	793	1	Cellular	cellular	JJ
cord-022313-2675sjlf	793	2	levels	level	NNS
cord-022313-2675sjlf	793	3	of	of	IN
cord-022313-2675sjlf	793	4	dolichyl	dolichyl	NN
cord-022313-2675sjlf	793	5	-	-	HYPH
cord-022313-2675sjlf	793	6	P	p	NN
cord-022313-2675sjlf	793	7	are	be	VBP
cord-022313-2675sjlf	793	8	not	not	RB
cord-022313-2675sjlf	793	9	the	the	DT
cord-022313-2675sjlf	793	10	only	only	JJ
cord-022313-2675sjlf	793	11	regulatory	regulatory	JJ
cord-022313-2675sjlf	793	12	factor	factor	NN
cord-022313-2675sjlf	793	13	Synthesis	Synthesis	NNP
cord-022313-2675sjlf	793	14	of	of	IN
cord-022313-2675sjlf	793	15	the	the	DT
cord-022313-2675sjlf	793	16	N	N	NNP
cord-022313-2675sjlf	793	17	-	-	HYPH
cord-022313-2675sjlf	793	18	linked	link	VBN
cord-022313-2675sjlf	793	19	oligosaccha	oligosaccha	NN
cord-022313-2675sjlf	793	20	rides	ride	NNS
cord-022313-2675sjlf	793	21	of	of	IN
cord-022313-2675sjlf	793	22	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	793	23	:	:	:
cord-022313-2675sjlf	793	24	Assembly	assembly	NN
cord-022313-2675sjlf	793	25	of	of	IN
cord-022313-2675sjlf	793	26	the	the	DT
cord-022313-2675sjlf	793	27	lipid	lipid	NN
cord-022313-2675sjlf	793	28	-	-	HYPH
cord-022313-2675sjlf	793	29	linked	link	VBN
cord-022313-2675sjlf	793	30	precursor	precursor	NN
cord-022313-2675sjlf	793	31	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	793	32	and	and	CC
cord-022313-2675sjlf	793	33	its	-PRON-	PRP$
cord-022313-2675sjlf	793	34	relation	relation	NN
cord-022313-2675sjlf	793	35	to	to	IN
cord-022313-2675sjlf	793	36	protein	protein	NN
cord-022313-2675sjlf	793	37	synthesis	synthesis	NN
cord-022313-2675sjlf	793	38	in	in	IN
cord-022313-2675sjlf	793	39	vivo	vivo	NN
cord-022313-2675sjlf	793	40	Relationship	relationship	NN
cord-022313-2675sjlf	793	41	between	between	IN
cord-022313-2675sjlf	793	42	oligosaccharide	oligosaccharide	NN
cord-022313-2675sjlf	793	43	-	-	HYPH
cord-022313-2675sjlf	793	44	lipid	lipid	NN
cord-022313-2675sjlf	793	45	synthesis	synthesis	NN
cord-022313-2675sjlf	793	46	and	and	CC
cord-022313-2675sjlf	793	47	protein	protein	NN
cord-022313-2675sjlf	793	48	synthesis	synthesis	NN
cord-022313-2675sjlf	793	49	in	in	IN
cord-022313-2675sjlf	793	50	mouse	mouse	NN
cord-022313-2675sjlf	793	51	LM	LM	NNP
cord-022313-2675sjlf	793	52	cells	cell	NNS
cord-022313-2675sjlf	793	53	Inhibition	inhibition	NN
cord-022313-2675sjlf	793	54	of	of	IN
cord-022313-2675sjlf	793	55	asparagine	asparagine	NN
cord-022313-2675sjlf	793	56	-	-	HYPH
cord-022313-2675sjlf	793	57	linked	link	VBN
cord-022313-2675sjlf	793	58	glycosylation	glycosylation	NN
cord-022313-2675sjlf	793	59	by	by	IN
cord-022313-2675sjlf	793	60	incorporation	incorporation	NN
cord-022313-2675sjlf	793	61	of	of	IN
cord-022313-2675sjlf	793	62	a	a	DT
cord-022313-2675sjlf	793	63	threonine	threonine	JJ
cord-022313-2675sjlf	793	64	analog	analog	NN
cord-022313-2675sjlf	793	65	into	into	IN
cord-022313-2675sjlf	793	66	nascent	nascent	JJ
cord-022313-2675sjlf	793	67	peptide	peptide	NN
cord-022313-2675sjlf	793	68	chains	chain	NNS
cord-022313-2675sjlf	794	1	Enhanced	enhanced	JJ
cord-022313-2675sjlf	794	2	degradation	degradation	NN
cord-022313-2675sjlf	794	3	of	of	IN
cord-022313-2675sjlf	794	4	cathep	cathep	JJ
cord-022313-2675sjlf	794	5	sin	sin	NN
cord-022313-2675sjlf	794	6	D	D	NNP
cord-022313-2675sjlf	794	7	synthesized	synthesize	VBN
cord-022313-2675sjlf	794	8	in	in	IN
cord-022313-2675sjlf	794	9	the	the	DT
cord-022313-2675sjlf	794	10	presence	presence	NN
cord-022313-2675sjlf	794	11	of	of	IN
cord-022313-2675sjlf	794	12	the	the	DT
cord-022313-2675sjlf	794	13	threonine	threonine	NN
cord-022313-2675sjlf	794	14	analog	analog	NN
cord-022313-2675sjlf	794	15	,	,	,
cord-022313-2675sjlf	794	16	/3-hydroxynorvaline	/3-hydroxynorvaline	NNP
cord-022313-2675sjlf	794	17	Effect	effect	NN
cord-022313-2675sjlf	794	18	of	of	IN
cord-022313-2675sjlf	794	19	the	the	DT
cord-022313-2675sjlf	794	20	threonine	threonine	JJ
cord-022313-2675sjlf	794	21	analog	analog	NN
cord-022313-2675sjlf	794	22	βhydroxynorvaline	βhydroxynorvaline	NN
cord-022313-2675sjlf	794	23	on	on	IN
cord-022313-2675sjlf	794	24	the	the	DT
cord-022313-2675sjlf	794	25	glycosylation	glycosylation	NN
cord-022313-2675sjlf	794	26	and	and	CC
cord-022313-2675sjlf	794	27	secretion	secretion	NN
cord-022313-2675sjlf	794	28	of	of	IN
cord-022313-2675sjlf	794	29	a-1	a-1	NNP
cord-022313-2675sjlf	794	30	-acid	-acid	JJ
cord-022313-2675sjlf	794	31	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	794	32	by	by	IN
cord-022313-2675sjlf	794	33	rat	rat	NN
cord-022313-2675sjlf	794	34	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	794	35	Incorporation	Incorporation	NNP
cord-022313-2675sjlf	794	36	of	of	IN
cord-022313-2675sjlf	794	37	betafluoroasparagine	betafluoroasparagine	NN
cord-022313-2675sjlf	794	38	into	into	IN
cord-022313-2675sjlf	794	39	peptides	peptide	NNS
cord-022313-2675sjlf	794	40	prevents	prevent	VBZ
cord-022313-2675sjlf	794	41	N	n	CD
cord-022313-2675sjlf	794	42	-	-	HYPH
cord-022313-2675sjlf	794	43	linked	link	VBN
cord-022313-2675sjlf	794	44	glycosylation	glycosylation	NN
cord-022313-2675sjlf	794	45	:	:	:
cord-022313-2675sjlf	794	46	In	in	FW
cord-022313-2675sjlf	794	47	vitro	vitro	FW
cord-022313-2675sjlf	794	48	studies	study	NNS
cord-022313-2675sjlf	794	49	with	with	IN
cord-022313-2675sjlf	794	50	synthetic	synthetic	JJ
cord-022313-2675sjlf	794	51	fluoropeptides	fluoropeptide	NNS
cord-022313-2675sjlf	794	52	Impairment	Impairment	NNP
cord-022313-2675sjlf	794	53	of	of	IN
cord-022313-2675sjlf	794	54	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	794	55	saccharide	saccharide	NN
cord-022313-2675sjlf	794	56	synthesis	synthesis	NN
cord-022313-2675sjlf	794	57	and	and	CC
cord-022313-2675sjlf	794	58	dolichol	dolichol	NN
cord-022313-2675sjlf	794	59	-	-	HYPH
cord-022313-2675sjlf	794	60	mediated	mediate	VBN
cord-022313-2675sjlf	794	61	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	794	62	assembly	assembly	NN
cord-022313-2675sjlf	794	63	in	in	IN
cord-022313-2675sjlf	794	64	aortic	aortic	JJ
cord-022313-2675sjlf	794	65	smooth	smooth	JJ
cord-022313-2675sjlf	794	66	muscle	muscle	NN
cord-022313-2675sjlf	794	67	cells	cell	NNS
cord-022313-2675sjlf	794	68	in	in	IN
cord-022313-2675sjlf	794	69	cul	cul	NN
cord-022313-2675sjlf	794	70	ture	ture	NN
cord-022313-2675sjlf	794	71	by	by	IN
cord-022313-2675sjlf	794	72	inhibitors	inhibitor	NNS
cord-022313-2675sjlf	794	73	of	of	IN
cord-022313-2675sjlf	794	74	cholesterol	cholesterol	NN
cord-022313-2675sjlf	794	75	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	794	76	Inter	Inter	NNP
cord-022313-2675sjlf	794	77	-	-	HYPH
cord-022313-2675sjlf	794	78	relationships	relationship	NNS
cord-022313-2675sjlf	794	79	between	between	IN
cord-022313-2675sjlf	794	80	dolichol	dolichol	NNP
cord-022313-2675sjlf	794	81	and	and	CC
cord-022313-2675sjlf	794	82	sterol	sterol	NN
cord-022313-2675sjlf	794	83	synthesis	synthesis	NN
cord-022313-2675sjlf	794	84	in	in	IN
cord-022313-2675sjlf	794	85	mammalian	mammalian	JJ
cord-022313-2675sjlf	794	86	cell	cell	NN
cord-022313-2675sjlf	794	87	cultures	culture	NNS
cord-022313-2675sjlf	794	88	Studies	Studies	NNPS
cord-022313-2675sjlf	794	89	on	on	IN
cord-022313-2675sjlf	794	90	the	the	DT
cord-022313-2675sjlf	794	91	regulation	regulation	NN
cord-022313-2675sjlf	794	92	of	of	IN
cord-022313-2675sjlf	794	93	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	794	94	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	794	95	:	:	:
cord-022313-2675sjlf	794	96	An	an	DT
cord-022313-2675sjlf	794	97	investigation	investigation	NN
cord-022313-2675sjlf	794	98	of	of	IN
cord-022313-2675sjlf	794	99	the	the	DT
cord-022313-2675sjlf	794	100	rate	rate	NN
cord-022313-2675sjlf	794	101	-	-	HYPH
cord-022313-2675sjlf	794	102	limiting	limit	VBG
cord-022313-2675sjlf	794	103	steps	step	NNS
cord-022313-2675sjlf	794	104	of	of	IN
cord-022313-2675sjlf	794	105	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	794	106	phosphate	phosphate	NN
cord-022313-2675sjlf	794	107	biosynthesis	biosynthesis	NNP
cord-022313-2675sjlf	794	108	Regulation	Regulation	NNP
cord-022313-2675sjlf	794	109	of	of	IN
cord-022313-2675sjlf	794	110	dolichol	dolichol	NNP
cord-022313-2675sjlf	794	111	and	and	CC
cord-022313-2675sjlf	794	112	of	of	IN
cord-022313-2675sjlf	794	113	cholesterol	cholesterol	NN
cord-022313-2675sjlf	794	114	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	794	115	in	in	IN
cord-022313-2675sjlf	794	116	cholesterolfed	cholesterolfed	NNP
cord-022313-2675sjlf	794	117	rabbits	rabbit	NNS
cord-022313-2675sjlf	794	118	Receptor	Receptor	NNP
cord-022313-2675sjlf	794	119	-	-	HYPH
cord-022313-2675sjlf	794	120	mediated	mediate	VBN
cord-022313-2675sjlf	794	121	endocytosis	endocytosis	NN
cord-022313-2675sjlf	794	122	:	:	:
cord-022313-2675sjlf	794	123	Concepts	concept	NNS
cord-022313-2675sjlf	794	124	emerging	emerge	VBG
cord-022313-2675sjlf	794	125	from	from	IN
cord-022313-2675sjlf	794	126	the	the	DT
cord-022313-2675sjlf	794	127	LDL	LDL	NNP
cord-022313-2675sjlf	794	128	receptor	receptor	NN
cord-022313-2675sjlf	794	129	system	system	NN
cord-022313-2675sjlf	794	130	Inhibition	inhibition	NN
cord-022313-2675sjlf	794	131	of	of	IN
cord-022313-2675sjlf	794	132	dolichyl	dolichyl	NNP
cord-022313-2675sjlf	794	133	phosphate	phosphate	NN
cord-022313-2675sjlf	794	134	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	794	135	by	by	IN
cord-022313-2675sjlf	794	136	compactin	compactin	NNS
cord-022313-2675sjlf	794	137	in	in	IN
cord-022313-2675sjlf	794	138	cultured	cultured	JJ
cord-022313-2675sjlf	794	139	rat	rat	NN
cord-022313-2675sjlf	794	140	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	794	141	Inhibition	Inhibition	NNP
cord-022313-2675sjlf	794	142	of	of	IN
cord-022313-2675sjlf	794	143	polyisoprenoid	polyisoprenoid	NNP
cord-022313-2675sjlf	794	144	and	and	CC
cord-022313-2675sjlf	794	145	glycopro	glycopro	NNP
cord-022313-2675sjlf	794	146	tein	tein	NNP
cord-022313-2675sjlf	794	147	biosynthesis	biosynthesis	NN
cord-022313-2675sjlf	794	148	causes	cause	VBZ
cord-022313-2675sjlf	794	149	abnormal	abnormal	JJ
cord-022313-2675sjlf	794	150	embryonic	embryonic	JJ
cord-022313-2675sjlf	794	151	development	development	NN
cord-022313-2675sjlf	794	152	Mevalonate	Mevalonate	NNP
cord-022313-2675sjlf	794	153	reverses	reverse	VBZ
cord-022313-2675sjlf	794	154	the	the	DT
cord-022313-2675sjlf	794	155	developmental	developmental	JJ
cord-022313-2675sjlf	794	156	arrest	arrest	NN
cord-022313-2675sjlf	794	157	of	of	IN
cord-022313-2675sjlf	794	158	preimplantation	preimplantation	NN
cord-022313-2675sjlf	794	159	mouse	mouse	NN
cord-022313-2675sjlf	794	160	embryos	embryo	NNS
cord-022313-2675sjlf	794	161	by	by	IN
cord-022313-2675sjlf	794	162	compactin	compactin	NNS
cord-022313-2675sjlf	794	163	,	,	,
cord-022313-2675sjlf	794	164	an	an	DT
cord-022313-2675sjlf	794	165	inhibitor	inhibitor	NN
cord-022313-2675sjlf	794	166	of	of	IN
cord-022313-2675sjlf	794	167	HMG	HMG	NNP
cord-022313-2675sjlf	794	168	CoA	coa	NN
cord-022313-2675sjlf	794	169	reductase	reductase	NN
cord-022313-2675sjlf	794	170	The	the	DT
cord-022313-2675sjlf	794	171	biogenesis	biogenesis	NN
cord-022313-2675sjlf	794	172	of	of	IN
cord-022313-2675sjlf	794	173	lysosomes	lysosome	NNS
cord-022313-2675sjlf	794	174	Plasma	plasma	NN
cord-022313-2675sjlf	794	175	cell	cell	NN
cord-022313-2675sjlf	794	176	immunoglobulin	immunoglobulin	NN
cord-022313-2675sjlf	794	177	secretion	secretion	NN
cord-022313-2675sjlf	794	178	:	:	:
cord-022313-2675sjlf	795	1	Arrest	arrest	NN
cord-022313-2675sjlf	795	2	is	be	VBZ
cord-022313-2675sjlf	795	3	accompanied	accompany	VBN
cord-022313-2675sjlf	795	4	by	by	IN
cord-022313-2675sjlf	795	5	alterations	alteration	NNS
cord-022313-2675sjlf	795	6	of	of	IN
cord-022313-2675sjlf	795	7	the	the	DT
cord-022313-2675sjlf	795	8	Golgi	Golgi	NNP
cord-022313-2675sjlf	795	9	complex	complex	JJ
cord-022313-2675sjlf	795	10	Monovalent	monovalent	JJ
cord-022313-2675sjlf	795	11	ionophores	ionophore	NNS
cord-022313-2675sjlf	795	12	inhibit	inhibit	VBP
cord-022313-2675sjlf	795	13	secretion	secretion	NN
cord-022313-2675sjlf	795	14	of	of	IN
cord-022313-2675sjlf	795	15	procollagen	procollagen	NN
cord-022313-2675sjlf	795	16	and	and	CC
cord-022313-2675sjlf	795	17	fibronectin	fibronectin	NN
cord-022313-2675sjlf	795	18	from	from	IN
cord-022313-2675sjlf	795	19	cultued	cultue	VBN
cord-022313-2675sjlf	795	20	human	human	JJ
cord-022313-2675sjlf	795	21	fibroblasts	fibroblast	NNS
cord-022313-2675sjlf	795	22	Perturbation	perturbation	NN
cord-022313-2675sjlf	795	23	of	of	IN
cord-022313-2675sjlf	795	24	vesicular	vesicular	JJ
cord-022313-2675sjlf	795	25	traffic	traffic	NN
cord-022313-2675sjlf	795	26	with	with	IN
cord-022313-2675sjlf	795	27	the	the	DT
cord-022313-2675sjlf	795	28	carboxylic	carboxylic	NN
cord-022313-2675sjlf	795	29	ionophore	ionophore	NNP
cord-022313-2675sjlf	795	30	monesin	monesin	NNP
cord-022313-2675sjlf	795	31	Vesicular	Vesicular	NNP
cord-022313-2675sjlf	795	32	stomatitis	stomatitis	NN
cord-022313-2675sjlf	795	33	virus	virus	NN
cord-022313-2675sjlf	795	34	and	and	CC
cord-022313-2675sjlf	795	35	sindbis	sindbis	NN
cord-022313-2675sjlf	795	36	virus	virus	NN
cord-022313-2675sjlf	795	37	glycoprotein	glycoprotein	NN
cord-022313-2675sjlf	795	38	transport	transport	NN
cord-022313-2675sjlf	795	39	to	to	IN
cord-022313-2675sjlf	795	40	the	the	DT
cord-022313-2675sjlf	795	41	cell	cell	NN
cord-022313-2675sjlf	795	42	surface	surface	NN
cord-022313-2675sjlf	795	43	is	be	VBZ
cord-022313-2675sjlf	795	44	inhibited	inhibit	VBN
cord-022313-2675sjlf	795	45	by	by	IN
cord-022313-2675sjlf	795	46	ionophores	ionophore	NNS
cord-022313-2675sjlf	795	47	Dissection	dissection	NN
cord-022313-2675sjlf	795	48	of	of	IN
cord-022313-2675sjlf	795	49	the	the	DT
cord-022313-2675sjlf	795	50	Golgi	Golgi	NNP
cord-022313-2675sjlf	795	51	complex	complex	NN
cord-022313-2675sjlf	795	52	.	.	.
cord-022313-2675sjlf	796	1	II	II	NNP
cord-022313-2675sjlf	796	2	.	.	.
cord-022313-2675sjlf	797	1	Density	density	NN
cord-022313-2675sjlf	797	2	separation	separation	NN
cord-022313-2675sjlf	797	3	of	of	IN
cord-022313-2675sjlf	797	4	specific	specific	JJ
cord-022313-2675sjlf	797	5	Golgi	Golgi	NNP
cord-022313-2675sjlf	797	6	functions	function	NNS
cord-022313-2675sjlf	797	7	in	in	IN
cord-022313-2675sjlf	797	8	virally	virally	RB
cord-022313-2675sjlf	797	9	infected	infect	VBN
cord-022313-2675sjlf	797	10	cells	cell	NNS
cord-022313-2675sjlf	797	11	treated	treat	VBN
cord-022313-2675sjlf	797	12	with	with	IN
cord-022313-2675sjlf	797	13	monensin	monensin	NNP
cord-022313-2675sjlf	797	14	Vesicles	Vesicles	NNP
cord-022313-2675sjlf	797	15	and	and	CC
cord-022313-2675sjlf	797	16	cisternae	cisternae	NNP
cord-022313-2675sjlf	797	17	in	in	IN
cord-022313-2675sjlf	797	18	the	the	DT
cord-022313-2675sjlf	797	19	trans	trans	NNP
cord-022313-2675sjlf	797	20	Golgi	Golgi	NNP
cord-022313-2675sjlf	797	21	apparatus	apparatus	NN
cord-022313-2675sjlf	797	22	of	of	IN
cord-022313-2675sjlf	797	23	human	human	JJ
cord-022313-2675sjlf	797	24	fibroblasts	fibroblast	NNS
cord-022313-2675sjlf	797	25	are	be	VBP
cord-022313-2675sjlf	797	26	acidic	acidic	JJ
cord-022313-2675sjlf	797	27	compartments	compartment	NNS
cord-022313-2675sjlf	797	28	Novel	Novel	NNP
cord-022313-2675sjlf	797	29	blockade	blockade	NN
cord-022313-2675sjlf	797	30	by	by	IN
cord-022313-2675sjlf	797	31	brefeldin	brefeldin	NNP
cord-022313-2675sjlf	797	32	A	A	NNP
cord-022313-2675sjlf	797	33	of	of	IN
cord-022313-2675sjlf	797	34	interacellular	interacellular	JJ
cord-022313-2675sjlf	797	35	transport	transport	NN
cord-022313-2675sjlf	797	36	of	of	IN
cord-022313-2675sjlf	797	37	secretory	secretory	JJ
cord-022313-2675sjlf	797	38	proteins	protein	NNS
cord-022313-2675sjlf	797	39	in	in	IN
cord-022313-2675sjlf	797	40	cultured	cultured	JJ
cord-022313-2675sjlf	797	41	rat	rat	NN
cord-022313-2675sjlf	797	42	hepatocytes	hepatocyte	NNS
cord-022313-2675sjlf	798	1	The	the	DT
cord-022313-2675sjlf	798	2	effects	effect	NNS
cord-022313-2675sjlf	798	3	of	of	IN
cord-022313-2675sjlf	798	4	brefeldin	brefeldin	NNP
cord-022313-2675sjlf	798	5	-	-	:
cord-022313-2675sjlf	798	6	A	a	NN
cord-022313-2675sjlf	798	7	on	on	IN
cord-022313-2675sjlf	798	8	the	the	DT
cord-022313-2675sjlf	798	9	high	high	JJ
cord-022313-2675sjlf	798	10	mannose	mannose	NN
cord-022313-2675sjlf	798	11	oligosaccharides	oligosaccharide	NNS
cord-022313-2675sjlf	798	12	of	of	IN
cord-022313-2675sjlf	798	13	mouse	mouse	NN
cord-022313-2675sjlf	798	14	thyrotropin	thyrotropin	NNP
cord-022313-2675sjlf	798	15	,	,	,
cord-022313-2675sjlf	798	16	free	free	JJ
cord-022313-2675sjlf	798	17	α	α	NN
cord-022313-2675sjlf	798	18	-	-	HYPH
cord-022313-2675sjlf	798	19	subunits	subunit	NNS
cord-022313-2675sjlf	798	20	and	and	CC
cord-022313-2675sjlf	798	21	total	total	JJ
cord-022313-2675sjlf	798	22	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	798	23	Effects	effect	NNS
cord-022313-2675sjlf	798	24	of	of	IN
cord-022313-2675sjlf	798	25	brefeldin	brefeldin	NNS
cord-022313-2675sjlf	798	26	A	A	NNP
cord-022313-2675sjlf	798	27	on	on	IN
cord-022313-2675sjlf	798	28	the	the	DT
cord-022313-2675sjlf	798	29	Golgi	Golgi	NNP
cord-022313-2675sjlf	798	30	complex	complex	JJ
cord-022313-2675sjlf	798	31	endoplasmic	endoplasmic	NN
cord-022313-2675sjlf	798	32	reticulum	reticulum	NN
cord-022313-2675sjlf	798	33	and	and	CC
cord-022313-2675sjlf	798	34	viral	viral	JJ
cord-022313-2675sjlf	798	35	envelope	envelope	NN
cord-022313-2675sjlf	798	36	glycoproteins	glycoprotein	NNS
cord-022313-2675sjlf	798	37	in	in	IN
cord-022313-2675sjlf	798	38	murine	murine	JJ
cord-022313-2675sjlf	798	39	erythroleukemia	erythroleukemia	NN
cord-022313-2675sjlf	798	40	cells	cell	VBZ
cord-022313-2675sjlf	798	41	Brefeldin	Brefeldin	NNP
cord-022313-2675sjlf	798	42	A	A	NNP
cord-022313-2675sjlf	798	43	,	,	,
cord-022313-2675sjlf	798	44	a	a	DT
cord-022313-2675sjlf	798	45	drug	drug	NN
cord-022313-2675sjlf	798	46	that	that	WDT
cord-022313-2675sjlf	798	47	blocks	block	VBZ
cord-022313-2675sjlf	798	48	secretion	secretion	NN
cord-022313-2675sjlf	798	49	,	,	,
cord-022313-2675sjlf	798	50	prevents	prevent	VBZ
cord-022313-2675sjlf	798	51	the	the	DT
cord-022313-2675sjlf	798	52	assembly	assembly	NN
cord-022313-2675sjlf	798	53	of	of	IN
cord-022313-2675sjlf	798	54	non	non	JJ
cord-022313-2675sjlf	798	55	-	-	JJ
cord-022313-2675sjlf	798	56	clathrin	clathrin	JJ
cord-022313-2675sjlf	798	57	coated	coated	JJ
cord-022313-2675sjlf	798	58	buds	bud	NNS
cord-022313-2675sjlf	798	59	on	on	IN
cord-022313-2675sjlf	798	60	Golgi	Golgi	NNP
cord-022313-2675sjlf	798	61	cisternae	cisternae	NNP
cord-022313-2675sjlf	799	1	A	a	DT
cord-022313-2675sjlf	799	2	microtubule	microtubule	NN
cord-022313-2675sjlf	799	3	binding	bind	VBG
cord-022313-2675sjlf	799	4	protein	protein	NN
cord-022313-2675sjlf	799	5	associated	associate	VBN
cord-022313-2675sjlf	799	6	with	with	IN
cord-022313-2675sjlf	799	7	membranes	membrane	NNS
cord-022313-2675sjlf	799	8	of	of	IN
cord-022313-2675sjlf	799	9	the	the	DT
cord-022313-2675sjlf	799	10	Golgi	Golgi	NNP
cord-022313-2675sjlf	799	11	apparatus	apparatus	NN
cord-022313-2675sjlf	799	12	Dissection	dissection	NN
cord-022313-2675sjlf	799	13	of	of	IN
cord-022313-2675sjlf	799	14	a	a	DT
cord-022313-2675sjlf	799	15	110	110	CD
cord-022313-2675sjlf	799	16	kDa	kDa	NNP
cord-022313-2675sjlf	799	17	peripheral	peripheral	JJ
cord-022313-2675sjlf	799	18	membrane	membrane	NN
cord-022313-2675sjlf	799	19	protein	protein	NN
cord-022313-2675sjlf	799	20	from	from	IN
cord-022313-2675sjlf	799	21	the	the	DT
cord-022313-2675sjlf	799	22	Golgi	Golgi	NNP
cord-022313-2675sjlf	799	23	apparatus	apparatus	NN
cord-022313-2675sjlf	799	24	is	be	VBZ
cord-022313-2675sjlf	799	25	an	an	DT
cord-022313-2675sjlf	799	26	early	early	JJ
cord-022313-2675sjlf	799	27	event	event	NN
cord-022313-2675sjlf	799	28	in	in	IN
cord-022313-2675sjlf	799	29	brefeldin	brefeldin	NNP
cord-022313-2675sjlf	799	30	A	a	DT
cord-022313-2675sjlf	799	31	action	action	NN
cord-022313-2675sjlf	799	32	A	a	DT
cord-022313-2675sjlf	799	33	coat	coat	NN
cord-022313-2675sjlf	799	34	subunit	subunit	NN
cord-022313-2675sjlf	799	35	of	of	IN
cord-022313-2675sjlf	799	36	Golgi	Golgi	NNP
cord-022313-2675sjlf	799	37	-	-	HYPH
cord-022313-2675sjlf	799	38	derived	derive	VBN
cord-022313-2675sjlf	799	39	non	non	JJ
cord-022313-2675sjlf	799	40	-	-	JJ
cord-022313-2675sjlf	799	41	clathrin	clathrin	JJ
cord-022313-2675sjlf	799	42	coated	coat	VBN
cord-022313-2675sjlf	799	43	vesicles	vesicle	NNS
cord-022313-2675sjlf	799	44	with	with	IN
cord-022313-2675sjlf	799	45	homology	homology	NN
cord-022313-2675sjlf	799	46	to	to	IN
cord-022313-2675sjlf	799	47	the	the	DT
cord-022313-2675sjlf	799	48	clathrin	clathrin	NN
cord-022313-2675sjlf	799	49	-	-	HYPH
cord-022313-2675sjlf	799	50	coated	coat	VBN
cord-022313-2675sjlf	799	51	vesicle	vesicle	NN
cord-022313-2675sjlf	799	52	coat	coat	NN
cord-022313-2675sjlf	799	53	protein	protein	NNP
cord-022313-2675sjlf	799	54	β	β	NNP
cord-022313-2675sjlf	799	55	-	-	HYPH
cord-022313-2675sjlf	799	56	adaptin	adaptin	NNP
cord-022313-2675sjlf	799	57	Biosynthesis	Biosynthesis	NNP
cord-022313-2675sjlf	799	58	of	of	IN
cord-022313-2675sjlf	799	59	the	the	DT
cord-022313-2675sjlf	799	60	glycolipid	glycolipid	NNP
cord-022313-2675sjlf	799	61	membrane	membrane	NN
cord-022313-2675sjlf	799	62	anchor	anchor	NN
cord-022313-2675sjlf	799	63	of	of	IN
cord-022313-2675sjlf	799	64	Trypanosoma	Trypanosoma	NNP
cord-022313-2675sjlf	799	65	brucei	brucei	NNP
cord-022313-2675sjlf	799	66	variant	variant	NN
cord-022313-2675sjlf	799	67	surface	surface	NN
cord-022313-2675sjlf	799	68	glycopro	glycopro	NNP
cord-022313-2675sjlf	799	69	teins	teins	NNP
cord-022313-2675sjlf	799	70	:	:	:
cord-022313-2675sjlf	800	1	Involvement	involvement	NN
cord-022313-2675sjlf	800	2	of	of	IN
cord-022313-2675sjlf	800	3	Dol	Dol	NNP
cord-022313-2675sjlf	800	4	-	-	HYPH
cord-022313-2675sjlf	800	5	P	p	NN
cord-022313-2675sjlf	800	6	-	-	HYPH
cord-022313-2675sjlf	800	7	man	man	NN
cord-022313-2675sjlf	800	8	Aberrant	aberrant	JJ
cord-022313-2675sjlf	800	9	processing	processing	NN
cord-022313-2675sjlf	800	10	of	of	IN
cord-022313-2675sjlf	800	11	alkaline	alkaline	JJ
cord-022313-2675sjlf	800	12	phos	phos	NNP
cord-022313-2675sjlf	800	13	phatase	phatase	NN
cord-022313-2675sjlf	800	14	precursor	precursor	NN
cord-022313-2675sjlf	800	15	caused	cause	VBN
cord-022313-2675sjlf	800	16	by	by	IN
cord-022313-2675sjlf	800	17	blocking	block	VBG
cord-022313-2675sjlf	800	18	the	the	DT
cord-022313-2675sjlf	800	19	synthesis	synthesis	NN
cord-022313-2675sjlf	800	20	of	of	IN
cord-022313-2675sjlf	800	21	gly	gly	NNP
cord-022313-2675sjlf	800	22	cosy	cosy	JJ
cord-022313-2675sjlf	800	23	lphosphatidylinositol	lphosphatidylinositol	NNP
cord-022313-2675sjlf	800	24	Mannosamine	Mannosamine	NNP
cord-022313-2675sjlf	800	25	,	,	,
cord-022313-2675sjlf	800	26	a	a	DT
cord-022313-2675sjlf	800	27	novel	novel	JJ
cord-022313-2675sjlf	800	28	inhibitor	inhibitor	NN
cord-022313-2675sjlf	800	29	of	of	IN
cord-022313-2675sjlf	800	30	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NNP
cord-022313-2675sjlf	800	31	incorpora	incorpora	NNP
cord-022313-2675sjlf	800	32	tion	tion	NNP
cord-022313-2675sjlf	800	33	into	into	IN
cord-022313-2675sjlf	800	34	proteins	protein	NNS
cord-022313-2675sjlf	800	35	Inhibition	Inhibition	NNP
cord-022313-2675sjlf	800	36	of	of	IN
cord-022313-2675sjlf	800	37	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NNP
cord-022313-2675sjlf	800	38	anchor	anchor	NN
cord-022313-2675sjlf	800	39	formation	formation	NN
cord-022313-2675sjlf	800	40	by	by	IN
cord-022313-2675sjlf	800	41	mannosamine	mannosamine	NNP