id	sid	tid	token	lemma	pos
cord-018572-e2qq4ngq	1	1	key	key	NN
cord-018572-e2qq4ngq	1	2	:	:	:
cord-018572-e2qq4ngq	2	1	cord-018572-e2qq4ngq	cord-018572-e2qq4ngq	JJ
cord-018572-e2qq4ngq	2	2	authors	author	NNS
cord-018572-e2qq4ngq	2	3	:	:	:
cord-018572-e2qq4ngq	2	4	Jackson	Jackson	NNP
cord-018572-e2qq4ngq	2	5	,	,	,
cord-018572-e2qq4ngq	2	6	Catherine	Catherine	NNP
cord-018572-e2qq4ngq	2	7	L.	L.	NNP
cord-018572-e2qq4ngq	3	1	title	title	NN
cord-018572-e2qq4ngq	3	2	:	:	:
cord-018572-e2qq4ngq	3	3	Arf	Arf	NNP
cord-018572-e2qq4ngq	3	4	Proteins	Proteins	NNPS
cord-018572-e2qq4ngq	3	5	and	and	CC
cord-018572-e2qq4ngq	3	6	Their	-PRON-	PRP$
cord-018572-e2qq4ngq	3	7	Regulators	regulator	NNS
cord-018572-e2qq4ngq	3	8	:	:	:
cord-018572-e2qq4ngq	4	1	At	at	IN
cord-018572-e2qq4ngq	4	2	the	the	DT
cord-018572-e2qq4ngq	4	3	Interface	Interface	NNP
cord-018572-e2qq4ngq	4	4	Between	between	IN
cord-018572-e2qq4ngq	4	5	Membrane	Membrane	NNP
cord-018572-e2qq4ngq	4	6	Lipids	lipid	NNS
cord-018572-e2qq4ngq	4	7	and	and	CC
cord-018572-e2qq4ngq	4	8	the	the	DT
cord-018572-e2qq4ngq	4	9	Protein	Protein	NNP
cord-018572-e2qq4ngq	4	10	Trafficking	Trafficking	NNP
cord-018572-e2qq4ngq	4	11	Machinery	Machinery	NNP
cord-018572-e2qq4ngq	4	12	date	date	NN
cord-018572-e2qq4ngq	4	13	:	:	:
cord-018572-e2qq4ngq	4	14	2014	2014	CD
cord-018572-e2qq4ngq	4	15	-	-	HYPH
cord-018572-e2qq4ngq	4	16	05	05	CD
cord-018572-e2qq4ngq	4	17	-	-	SYM
cord-018572-e2qq4ngq	4	18	22	22	CD
cord-018572-e2qq4ngq	4	19	journal	journal	NN
cord-018572-e2qq4ngq	4	20	:	:	:
cord-018572-e2qq4ngq	5	1	Ras	Ras	NNP
cord-018572-e2qq4ngq	5	2	Superfamily	Superfamily	NNP
cord-018572-e2qq4ngq	5	3	Small	small	JJ
cord-018572-e2qq4ngq	5	4	G	g	NN
cord-018572-e2qq4ngq	5	5	Proteins	protein	NNS
cord-018572-e2qq4ngq	5	6	:	:	:
cord-018572-e2qq4ngq	5	7	Biology	biology	NN
cord-018572-e2qq4ngq	5	8	and	and	CC
cord-018572-e2qq4ngq	5	9	Mechanisms	Mechanisms	NNP
cord-018572-e2qq4ngq	5	10	2	2	CD
cord-018572-e2qq4ngq	6	1	DOI	DOI	NNP
cord-018572-e2qq4ngq	6	2	:	:	:
cord-018572-e2qq4ngq	6	3	10.1007/978	10.1007/978	CD
cord-018572-e2qq4ngq	6	4	-	-	HYPH
cord-018572-e2qq4ngq	6	5	3	3	CD
cord-018572-e2qq4ngq	6	6	-	-	HYPH
cord-018572-e2qq4ngq	6	7	319	319	CD
cord-018572-e2qq4ngq	6	8	-	-	HYPH
cord-018572-e2qq4ngq	6	9	07761	07761	CD
cord-018572-e2qq4ngq	6	10	-	-	SYM
cord-018572-e2qq4ngq	6	11	1_8	1_8	CD
cord-018572-e2qq4ngq	6	12	sha	sha	NNP
cord-018572-e2qq4ngq	6	13	:	:	:
cord-018572-e2qq4ngq	6	14	319eb2b655887aed733233c6c7da197486ee920b	319eb2b655887aed733233c6c7da197486ee920b	CD
cord-018572-e2qq4ngq	6	15	doc_id	doc_id	CD
cord-018572-e2qq4ngq	6	16	:	:	:
cord-018572-e2qq4ngq	6	17	18572	18572	CD
cord-018572-e2qq4ngq	6	18	cord_uid	cord_uid	FW
cord-018572-e2qq4ngq	6	19	:	:	:
cord-018572-e2qq4ngq	7	1	e2qq4ngq	e2qq4ngq	NFP
cord-018572-e2qq4ngq	7	2	The	the	DT
cord-018572-e2qq4ngq	7	3	Arf	Arf	NNP
cord-018572-e2qq4ngq	7	4	small	small	JJ
cord-018572-e2qq4ngq	7	5	GTP	gtp	NN
cord-018572-e2qq4ngq	7	6	-	-	HYPH
cord-018572-e2qq4ngq	7	7	binding	bind	VBG
cord-018572-e2qq4ngq	7	8	(	(	-LRB-
cord-018572-e2qq4ngq	7	9	G	g	NN
cord-018572-e2qq4ngq	7	10	)	)	-RRB-
cord-018572-e2qq4ngq	7	11	proteins	protein	NNS
cord-018572-e2qq4ngq	7	12	regulate	regulate	VBP
cord-018572-e2qq4ngq	7	13	membrane	membrane	NN
cord-018572-e2qq4ngq	7	14	traffic	traffic	NN
cord-018572-e2qq4ngq	7	15	and	and	CC
cord-018572-e2qq4ngq	7	16	organelle	organelle	NN
cord-018572-e2qq4ngq	7	17	structure	structure	NN
cord-018572-e2qq4ngq	7	18	in	in	IN
cord-018572-e2qq4ngq	7	19	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	7	20	cells	cell	NNS
cord-018572-e2qq4ngq	7	21	through	through	IN
cord-018572-e2qq4ngq	7	22	a	a	DT
cord-018572-e2qq4ngq	7	23	regulated	regulate	VBN
cord-018572-e2qq4ngq	7	24	cycle	cycle	NN
cord-018572-e2qq4ngq	7	25	of	of	IN
cord-018572-e2qq4ngq	7	26	GTP	gtp	NN
cord-018572-e2qq4ngq	7	27	binding	binding	NN
cord-018572-e2qq4ngq	7	28	and	and	CC
cord-018572-e2qq4ngq	7	29	hydrolysis	hydrolysis	NN
cord-018572-e2qq4ngq	7	30	.	.	.
cord-018572-e2qq4ngq	8	1	The	the	DT
cord-018572-e2qq4ngq	8	2	first	first	JJ
cord-018572-e2qq4ngq	8	3	function	function	NN
cord-018572-e2qq4ngq	8	4	identified	identify	VBN
cord-018572-e2qq4ngq	8	5	for	for	IN
cord-018572-e2qq4ngq	8	6	Arf	Arf	NNP
cord-018572-e2qq4ngq	8	7	proteins	protein	NNS
cord-018572-e2qq4ngq	8	8	was	be	VBD
cord-018572-e2qq4ngq	8	9	recruitment	recruitment	NN
cord-018572-e2qq4ngq	8	10	of	of	IN
cord-018572-e2qq4ngq	8	11	cytosolic	cytosolic	JJ
cord-018572-e2qq4ngq	8	12	coat	coat	NN
cord-018572-e2qq4ngq	8	13	complexes	complex	NNS
cord-018572-e2qq4ngq	8	14	to	to	IN
cord-018572-e2qq4ngq	8	15	membranes	membrane	NNS
cord-018572-e2qq4ngq	8	16	to	to	TO
cord-018572-e2qq4ngq	8	17	mediate	mediate	VB
cord-018572-e2qq4ngq	8	18	vesicle	vesicle	NN
cord-018572-e2qq4ngq	8	19	formation	formation	NN
cord-018572-e2qq4ngq	8	20	.	.	.
cord-018572-e2qq4ngq	9	1	However	however	RB
cord-018572-e2qq4ngq	9	2	,	,	,
cord-018572-e2qq4ngq	9	3	subsequent	subsequent	JJ
cord-018572-e2qq4ngq	9	4	studies	study	NNS
cord-018572-e2qq4ngq	9	5	have	have	VBP
cord-018572-e2qq4ngq	9	6	uncovered	uncover	VBN
cord-018572-e2qq4ngq	9	7	additional	additional	JJ
cord-018572-e2qq4ngq	9	8	functions	function	NNS
cord-018572-e2qq4ngq	9	9	,	,	,
cord-018572-e2qq4ngq	9	10	including	include	VBG
cord-018572-e2qq4ngq	9	11	roles	role	NNS
cord-018572-e2qq4ngq	9	12	in	in	IN
cord-018572-e2qq4ngq	9	13	plasma	plasma	NN
cord-018572-e2qq4ngq	9	14	membrane	membrane	NN
cord-018572-e2qq4ngq	9	15	signalling	signal	VBG
cord-018572-e2qq4ngq	9	16	pathways	pathway	NNS
cord-018572-e2qq4ngq	9	17	,	,	,
cord-018572-e2qq4ngq	9	18	cytoskeleton	cytoskeleton	NN
cord-018572-e2qq4ngq	9	19	regulation	regulation	NN
cord-018572-e2qq4ngq	9	20	,	,	,
cord-018572-e2qq4ngq	9	21	lipid	lipid	NN
cord-018572-e2qq4ngq	9	22	droplet	droplet	NN
cord-018572-e2qq4ngq	9	23	function	function	NN
cord-018572-e2qq4ngq	9	24	,	,	,
cord-018572-e2qq4ngq	9	25	and	and	CC
cord-018572-e2qq4ngq	9	26	non	non	JJ
cord-018572-e2qq4ngq	9	27	-	-	JJ
cord-018572-e2qq4ngq	9	28	vesicular	vesicular	JJ
cord-018572-e2qq4ngq	9	29	lipid	lipid	NN
cord-018572-e2qq4ngq	9	30	transport	transport	NN
cord-018572-e2qq4ngq	9	31	.	.	.
cord-018572-e2qq4ngq	10	1	In	in	IN
cord-018572-e2qq4ngq	10	2	contrast	contrast	NN
cord-018572-e2qq4ngq	10	3	to	to	IN
cord-018572-e2qq4ngq	10	4	other	other	JJ
cord-018572-e2qq4ngq	10	5	families	family	NNS
cord-018572-e2qq4ngq	10	6	of	of	IN
cord-018572-e2qq4ngq	10	7	G	g	NN
cord-018572-e2qq4ngq	10	8	proteins	protein	NNS
cord-018572-e2qq4ngq	10	9	,	,	,
cord-018572-e2qq4ngq	10	10	there	there	EX
cord-018572-e2qq4ngq	10	11	are	be	VBP
cord-018572-e2qq4ngq	10	12	only	only	RB
cord-018572-e2qq4ngq	10	13	a	a	DT
cord-018572-e2qq4ngq	10	14	few	few	JJ
cord-018572-e2qq4ngq	10	15	Arf	Arf	NNP
cord-018572-e2qq4ngq	10	16	proteins	protein	NNS
cord-018572-e2qq4ngq	10	17	in	in	IN
cord-018572-e2qq4ngq	10	18	each	each	DT
cord-018572-e2qq4ngq	10	19	organism	organism	NN
cord-018572-e2qq4ngq	10	20	,	,	,
cord-018572-e2qq4ngq	10	21	yet	yet	CC
cord-018572-e2qq4ngq	10	22	they	-PRON-	PRP
cord-018572-e2qq4ngq	10	23	function	function	VBP
cord-018572-e2qq4ngq	10	24	specifically	specifically	RB
cord-018572-e2qq4ngq	10	25	at	at	IN
cord-018572-e2qq4ngq	10	26	many	many	JJ
cord-018572-e2qq4ngq	10	27	different	different	JJ
cord-018572-e2qq4ngq	10	28	cellular	cellular	JJ
cord-018572-e2qq4ngq	10	29	locations	location	NNS
cord-018572-e2qq4ngq	10	30	.	.	.
cord-018572-e2qq4ngq	11	1	Part	part	NN
cord-018572-e2qq4ngq	11	2	of	of	IN
cord-018572-e2qq4ngq	11	3	this	this	DT
cord-018572-e2qq4ngq	11	4	specificity	specificity	NN
cord-018572-e2qq4ngq	11	5	is	be	VBZ
cord-018572-e2qq4ngq	11	6	achieved	achieve	VBN
cord-018572-e2qq4ngq	11	7	by	by	IN
cord-018572-e2qq4ngq	11	8	formation	formation	NN
cord-018572-e2qq4ngq	11	9	of	of	IN
cord-018572-e2qq4ngq	11	10	complexes	complex	NNS
cord-018572-e2qq4ngq	11	11	with	with	IN
cord-018572-e2qq4ngq	11	12	their	-PRON-	PRP$
cord-018572-e2qq4ngq	11	13	guanine	guanine	NN
cord-018572-e2qq4ngq	11	14	nucleotide	nucleotide	NN
cord-018572-e2qq4ngq	11	15	-	-	HYPH
cord-018572-e2qq4ngq	11	16	exchange	exchange	NN
cord-018572-e2qq4ngq	11	17	factors	factor	NNS
cord-018572-e2qq4ngq	11	18	(	(	-LRB-
cord-018572-e2qq4ngq	11	19	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	11	20	)	)	-RRB-
cord-018572-e2qq4ngq	11	21	and	and	CC
cord-018572-e2qq4ngq	11	22	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	11	23	activating	activate	VBG
cord-018572-e2qq4ngq	11	24	proteins	protein	NNS
cord-018572-e2qq4ngq	11	25	(	(	-LRB-
cord-018572-e2qq4ngq	11	26	GAPs	GAPs	NNP
cord-018572-e2qq4ngq	11	27	)	)	-RRB-
cord-018572-e2qq4ngq	11	28	that	that	WDT
cord-018572-e2qq4ngq	11	29	catalyse	catalyse	VBP
cord-018572-e2qq4ngq	11	30	GTP	gtp	NN
cord-018572-e2qq4ngq	11	31	binding	binding	NN
cord-018572-e2qq4ngq	11	32	and	and	CC
cord-018572-e2qq4ngq	11	33	hydrolysis	hydrolysis	NN
cord-018572-e2qq4ngq	11	34	,	,	,
cord-018572-e2qq4ngq	11	35	respectively	respectively	RB
cord-018572-e2qq4ngq	11	36	.	.	.
cord-018572-e2qq4ngq	12	1	Because	because	IN
cord-018572-e2qq4ngq	12	2	these	these	DT
cord-018572-e2qq4ngq	12	3	regulators	regulator	NNS
cord-018572-e2qq4ngq	12	4	outnumber	outnumber	VBP
cord-018572-e2qq4ngq	12	5	their	-PRON-	PRP$
cord-018572-e2qq4ngq	12	6	Arf	Arf	NNP
cord-018572-e2qq4ngq	12	7	substrates	substrate	NNS
cord-018572-e2qq4ngq	12	8	by	by	IN
cord-018572-e2qq4ngq	12	9	at	at	RB
cord-018572-e2qq4ngq	12	10	least	least	JJS
cord-018572-e2qq4ngq	12	11	3-to-1	3-to-1	NN
cord-018572-e2qq4ngq	12	12	,	,	,
cord-018572-e2qq4ngq	12	13	an	an	DT
cord-018572-e2qq4ngq	12	14	important	important	JJ
cord-018572-e2qq4ngq	12	15	aspect	aspect	NN
cord-018572-e2qq4ngq	12	16	of	of	IN
cord-018572-e2qq4ngq	12	17	understanding	understand	VBG
cord-018572-e2qq4ngq	12	18	Arf	Arf	NNP
cord-018572-e2qq4ngq	12	19	function	function	NN
cord-018572-e2qq4ngq	12	20	is	be	VBZ
cord-018572-e2qq4ngq	12	21	elucidating	elucidate	VBG
cord-018572-e2qq4ngq	12	22	the	the	DT
cord-018572-e2qq4ngq	12	23	mechanisms	mechanism	NNS
cord-018572-e2qq4ngq	12	24	by	by	IN
cord-018572-e2qq4ngq	12	25	which	which	WDT
cord-018572-e2qq4ngq	12	26	a	a	DT
cord-018572-e2qq4ngq	12	27	single	single	JJ
cord-018572-e2qq4ngq	12	28	Arf	Arf	NNP
cord-018572-e2qq4ngq	12	29	protein	protein	NN
cord-018572-e2qq4ngq	12	30	is	be	VBZ
cord-018572-e2qq4ngq	12	31	incorporated	incorporate	VBN
cord-018572-e2qq4ngq	12	32	into	into	IN
cord-018572-e2qq4ngq	12	33	different	different	JJ
cord-018572-e2qq4ngq	12	34	GEF	GEF	NNP
cord-018572-e2qq4ngq	12	35	,	,	,
cord-018572-e2qq4ngq	12	36	GAP	gap	NN
cord-018572-e2qq4ngq	12	37	,	,	,
cord-018572-e2qq4ngq	12	38	and	and	CC
cord-018572-e2qq4ngq	12	39	effector	effector	NN
cord-018572-e2qq4ngq	12	40	complexes	complex	NNS
cord-018572-e2qq4ngq	12	41	.	.	.
cord-018572-e2qq4ngq	13	1	New	new	JJ
cord-018572-e2qq4ngq	13	2	insights	insight	NNS
cord-018572-e2qq4ngq	13	3	into	into	IN
cord-018572-e2qq4ngq	13	4	these	these	DT
cord-018572-e2qq4ngq	13	5	mechanisms	mechanism	NNS
cord-018572-e2qq4ngq	13	6	have	have	VBP
cord-018572-e2qq4ngq	13	7	come	come	VBN
cord-018572-e2qq4ngq	13	8	from	from	IN
cord-018572-e2qq4ngq	13	9	recent	recent	JJ
cord-018572-e2qq4ngq	13	10	studies	study	NNS
cord-018572-e2qq4ngq	13	11	showing	show	VBG
cord-018572-e2qq4ngq	13	12	GEF	gef	NN
cord-018572-e2qq4ngq	13	13	–	–	:
cord-018572-e2qq4ngq	13	14	effector	effector	NN
cord-018572-e2qq4ngq	13	15	interactions	interaction	NNS
cord-018572-e2qq4ngq	13	16	,	,	,
cord-018572-e2qq4ngq	13	17	Arf	Arf	NNP
cord-018572-e2qq4ngq	13	18	activation	activation	NN
cord-018572-e2qq4ngq	13	19	cascades	cascade	NNS
cord-018572-e2qq4ngq	13	20	,	,	,
cord-018572-e2qq4ngq	13	21	and	and	CC
cord-018572-e2qq4ngq	13	22	positive	positive	JJ
cord-018572-e2qq4ngq	13	23	feedback	feedback	NN
cord-018572-e2qq4ngq	13	24	loops	loop	NNS
cord-018572-e2qq4ngq	13	25	.	.	.
cord-018572-e2qq4ngq	14	1	A	a	DT
cord-018572-e2qq4ngq	14	2	unifying	unifying	JJ
cord-018572-e2qq4ngq	14	3	theme	theme	NN
cord-018572-e2qq4ngq	14	4	in	in	IN
cord-018572-e2qq4ngq	14	5	the	the	DT
cord-018572-e2qq4ngq	14	6	function	function	NN
cord-018572-e2qq4ngq	14	7	of	of	IN
cord-018572-e2qq4ngq	14	8	Arf	Arf	NNP
cord-018572-e2qq4ngq	14	9	proteins	protein	NNS
cord-018572-e2qq4ngq	14	10	,	,	,
cord-018572-e2qq4ngq	14	11	carried	carry	VBD
cord-018572-e2qq4ngq	14	12	out	out	RP
cord-018572-e2qq4ngq	14	13	in	in	IN
cord-018572-e2qq4ngq	14	14	conjunction	conjunction	NN
cord-018572-e2qq4ngq	14	15	with	with	IN
cord-018572-e2qq4ngq	14	16	their	-PRON-	PRP$
cord-018572-e2qq4ngq	14	17	regulators	regulator	NNS
cord-018572-e2qq4ngq	14	18	and	and	CC
cord-018572-e2qq4ngq	14	19	effectors	effector	NNS
cord-018572-e2qq4ngq	14	20	,	,	,
cord-018572-e2qq4ngq	14	21	is	be	VBZ
cord-018572-e2qq4ngq	14	22	sensing	sense	VBG
cord-018572-e2qq4ngq	14	23	and	and	CC
cord-018572-e2qq4ngq	14	24	modulating	modulate	VBG
cord-018572-e2qq4ngq	14	25	the	the	DT
cord-018572-e2qq4ngq	14	26	properties	property	NNS
cord-018572-e2qq4ngq	14	27	of	of	IN
cord-018572-e2qq4ngq	14	28	the	the	DT
cord-018572-e2qq4ngq	14	29	lipids	lipid	NNS
cord-018572-e2qq4ngq	14	30	that	that	WDT
cord-018572-e2qq4ngq	14	31	make	make	VBP
cord-018572-e2qq4ngq	14	32	up	up	RP
cord-018572-e2qq4ngq	14	33	cellular	cellular	JJ
cord-018572-e2qq4ngq	14	34	membranes	membrane	NNS
cord-018572-e2qq4ngq	14	35	.	.	.
cord-018572-e2qq4ngq	15	1	Arf	Arf	NNP
cord-018572-e2qq4ngq	15	2	proteins	protein	NNS
cord-018572-e2qq4ngq	15	3	are	be	VBP
cord-018572-e2qq4ngq	15	4	low	low	JJ
cord-018572-e2qq4ngq	15	5	molecular	molecular	JJ
cord-018572-e2qq4ngq	15	6	weight	weight	NN
cord-018572-e2qq4ngq	15	7	GTP	gtp	NN
cord-018572-e2qq4ngq	15	8	-	-	HYPH
cord-018572-e2qq4ngq	15	9	binding	bind	VBG
cord-018572-e2qq4ngq	15	10	(	(	-LRB-
cord-018572-e2qq4ngq	15	11	G	g	NN
cord-018572-e2qq4ngq	15	12	)	)	-RRB-
cord-018572-e2qq4ngq	15	13	proteins	protein	NNS
cord-018572-e2qq4ngq	15	14	that	that	WDT
cord-018572-e2qq4ngq	15	15	are	be	VBP
cord-018572-e2qq4ngq	15	16	regulated	regulate	VBN
cord-018572-e2qq4ngq	15	17	through	through	IN
cord-018572-e2qq4ngq	15	18	a	a	DT
cord-018572-e2qq4ngq	15	19	cycle	cycle	NN
cord-018572-e2qq4ngq	15	20	of	of	IN
cord-018572-e2qq4ngq	15	21	GTP	gtp	NN
cord-018572-e2qq4ngq	15	22	binding	binding	NN
cord-018572-e2qq4ngq	15	23	and	and	CC
cord-018572-e2qq4ngq	15	24	hydrolysis	hydrolysis	NN
cord-018572-e2qq4ngq	15	25	,	,	,
cord-018572-e2qq4ngq	15	26	in	in	IN
cord-018572-e2qq4ngq	15	27	which	which	WDT
cord-018572-e2qq4ngq	15	28	binding	binding	NN
cord-018572-e2qq4ngq	15	29	of	of	IN
cord-018572-e2qq4ngq	15	30	GTP	GTP	NNP
cord-018572-e2qq4ngq	15	31	activates	activate	VBZ
cord-018572-e2qq4ngq	15	32	and	and	CC
cord-018572-e2qq4ngq	15	33	GTP	GTP	NNP
cord-018572-e2qq4ngq	15	34	hydrolysis	hydrolysis	NN
cord-018572-e2qq4ngq	15	35	inactivates	inactivate	VBZ
cord-018572-e2qq4ngq	15	36	the	the	DT
cord-018572-e2qq4ngq	15	37	G	g	NN
cord-018572-e2qq4ngq	15	38	protein	protein	NN
cord-018572-e2qq4ngq	15	39	(	(	-LRB-
cord-018572-e2qq4ngq	15	40	Donaldson	Donaldson	NNP
cord-018572-e2qq4ngq	15	41	and	and	CC
cord-018572-e2qq4ngq	15	42	Jackson	Jackson	NNP
cord-018572-e2qq4ngq	15	43	2011	2011	CD
cord-018572-e2qq4ngq	15	44	;	;	:
cord-018572-e2qq4ngq	15	45	Gillingham	Gillingham	NNP
cord-018572-e2qq4ngq	15	46	and	and	CC
cord-018572-e2qq4ngq	15	47	Munro	Munro	NNP
cord-018572-e2qq4ngq	15	48	2007b	2007b	CD
cord-018572-e2qq4ngq	15	49	)	)	-RRB-
cord-018572-e2qq4ngq	16	1	(	(	-LRB-
cord-018572-e2qq4ngq	16	2	Fig	Fig	NNP
cord-018572-e2qq4ngq	16	3	.	.	.
cord-018572-e2qq4ngq	16	4	8.1	8.1	CD
cord-018572-e2qq4ngq	16	5	)	)	-RRB-
cord-018572-e2qq4ngq	16	6	.	.	.
cord-018572-e2qq4ngq	17	1	In	in	IN
cord-018572-e2qq4ngq	17	2	their	-PRON-	PRP$
cord-018572-e2qq4ngq	17	3	active	active	JJ
cord-018572-e2qq4ngq	17	4	GTP	gtp	NN
cord-018572-e2qq4ngq	17	5	-	-	HYPH
cord-018572-e2qq4ngq	17	6	bound	bind	VBN
cord-018572-e2qq4ngq	17	7	form	form	NN
cord-018572-e2qq4ngq	17	8	,	,	,
cord-018572-e2qq4ngq	17	9	Arf	Arf	NNP
cord-018572-e2qq4ngq	17	10	proteins	protein	NNS
cord-018572-e2qq4ngq	17	11	are	be	VBP
cord-018572-e2qq4ngq	17	12	tightly	tightly	RB
cord-018572-e2qq4ngq	17	13	associated	associate	VBN
cord-018572-e2qq4ngq	17	14	with	with	IN
cord-018572-e2qq4ngq	17	15	the	the	DT
cord-018572-e2qq4ngq	17	16	membrane	membrane	NN
cord-018572-e2qq4ngq	17	17	surface	surface	NN
cord-018572-e2qq4ngq	17	18	.	.	.
cord-018572-e2qq4ngq	18	1	Hence	hence	RB
cord-018572-e2qq4ngq	18	2	they	-PRON-	PRP
cord-018572-e2qq4ngq	18	3	bring	bring	VBP
cord-018572-e2qq4ngq	18	4	their	-PRON-	PRP$
cord-018572-e2qq4ngq	18	5	effectors	effector	NNS
cord-018572-e2qq4ngq	18	6	,	,	,
cord-018572-e2qq4ngq	18	7	proteins	protein	NNS
cord-018572-e2qq4ngq	18	8	that	that	WDT
cord-018572-e2qq4ngq	18	9	bind	bind	VBP
cord-018572-e2qq4ngq	18	10	specifically	specifically	RB
cord-018572-e2qq4ngq	18	11	to	to	IN
cord-018572-e2qq4ngq	18	12	the	the	DT
cord-018572-e2qq4ngq	18	13	GTP	GTP	NNP
cord-018572-e2qq4ngq	18	14	-	-	HYPH
cord-018572-e2qq4ngq	18	15	bound	bind	VBN
cord-018572-e2qq4ngq	18	16	form	form	NN
cord-018572-e2qq4ngq	18	17	,	,	,
cord-018572-e2qq4ngq	18	18	into	into	IN
cord-018572-e2qq4ngq	18	19	close	close	JJ
cord-018572-e2qq4ngq	18	20	contact	contact	NN
cord-018572-e2qq4ngq	18	21	with	with	IN
cord-018572-e2qq4ngq	18	22	the	the	DT
cord-018572-e2qq4ngq	18	23	lipid	lipid	NN
cord-018572-e2qq4ngq	18	24	bilayer	bilayer	NN
cord-018572-e2qq4ngq	18	25	.	.	.
cord-018572-e2qq4ngq	19	1	These	these	DT
cord-018572-e2qq4ngq	19	2	Arf	Arf	NNP
cord-018572-e2qq4ngq	19	3	effector	effector	NN
cord-018572-e2qq4ngq	19	4	proteins	protein	NNS
cord-018572-e2qq4ngq	19	5	include	include	VBP
cord-018572-e2qq4ngq	19	6	coat	coat	NN
cord-018572-e2qq4ngq	19	7	complexes	complex	NNS
cord-018572-e2qq4ngq	19	8	that	that	WDT
cord-018572-e2qq4ngq	19	9	deform	deform	VBP
cord-018572-e2qq4ngq	19	10	membranes	membrane	NNS
cord-018572-e2qq4ngq	19	11	and	and	CC
cord-018572-e2qq4ngq	19	12	promote	promote	VB
cord-018572-e2qq4ngq	19	13	cargo	cargo	NN
cord-018572-e2qq4ngq	19	14	sorting	sorting	NN
cord-018572-e2qq4ngq	19	15	,	,	,
cord-018572-e2qq4ngq	19	16	enzymes	enzyme	NNS
cord-018572-e2qq4ngq	19	17	such	such	JJ
cord-018572-e2qq4ngq	19	18	as	as	IN
cord-018572-e2qq4ngq	19	19	the	the	DT
cord-018572-e2qq4ngq	19	20	phosphatidylinositol	phosphatidylinositol	JJ
cord-018572-e2qq4ngq	19	21	kinases	kinase	NNS
cord-018572-e2qq4ngq	19	22	that	that	WDT
cord-018572-e2qq4ngq	19	23	alter	alter	VBP
cord-018572-e2qq4ngq	19	24	membrane	membrane	NN
cord-018572-e2qq4ngq	19	25	lipid	lipid	NN
cord-018572-e2qq4ngq	19	26	composition	composition	NN
cord-018572-e2qq4ngq	19	27	,	,	,
cord-018572-e2qq4ngq	19	28	and	and	CC
cord-018572-e2qq4ngq	19	29	actin	actin	NN
cord-018572-e2qq4ngq	19	30	cytoskeletal	cytoskeletal	JJ
cord-018572-e2qq4ngq	19	31	components	component	NNS
cord-018572-e2qq4ngq	19	32	(	(	-LRB-
cord-018572-e2qq4ngq	19	33	Table	Table	NNP
cord-018572-e2qq4ngq	19	34	8	8	CD
cord-018572-e2qq4ngq	19	35	.1	.1	CD
cord-018572-e2qq4ngq	19	36	)	)	-RRB-
cord-018572-e2qq4ngq	19	37	.	.	.
cord-018572-e2qq4ngq	20	1	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	20	2	is	be	VBZ
cord-018572-e2qq4ngq	20	3	the	the	DT
cord-018572-e2qq4ngq	20	4	founding	found	VBG
cord-018572-e2qq4ngq	20	5	member	member	NN
cord-018572-e2qq4ngq	20	6	of	of	IN
cord-018572-e2qq4ngq	20	7	the	the	DT
cord-018572-e2qq4ngq	20	8	family	family	NN
cord-018572-e2qq4ngq	20	9	,	,	,
cord-018572-e2qq4ngq	20	10	and	and	CC
cord-018572-e2qq4ngq	20	11	was	be	VBD
cord-018572-e2qq4ngq	20	12	originally	originally	RB
cord-018572-e2qq4ngq	20	13	identified	identify	VBN
cord-018572-e2qq4ngq	20	14	as	as	IN
cord-018572-e2qq4ngq	20	15	a	a	DT
cord-018572-e2qq4ngq	20	16	protein	protein	NN
cord-018572-e2qq4ngq	20	17	factor	factor	NN
cord-018572-e2qq4ngq	20	18	required	require	VBN
cord-018572-e2qq4ngq	20	19	for	for	IN
cord-018572-e2qq4ngq	20	20	the	the	DT
cord-018572-e2qq4ngq	20	21	ADP	ADP	NNP
cord-018572-e2qq4ngq	20	22	-	-	HYPH
cord-018572-e2qq4ngq	20	23	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	20	24	of	of	IN
cord-018572-e2qq4ngq	20	25	the	the	DT
cord-018572-e2qq4ngq	20	26	adenylate	adenylate	NN
cord-018572-e2qq4ngq	20	27	cyclase	cyclase	NN
cord-018572-e2qq4ngq	20	28	activator	activator	NN
cord-018572-e2qq4ngq	20	29	Gsα	Gsα	NNP
cord-018572-e2qq4ngq	20	30	by	by	IN
cord-018572-e2qq4ngq	20	31	cholera	cholera	NN
cord-018572-e2qq4ngq	20	32	toxin	toxin	NN
cord-018572-e2qq4ngq	20	33	(	(	-LRB-
cord-018572-e2qq4ngq	20	34	Schleifer	Schleifer	NNP
cord-018572-e2qq4ngq	20	35	et	et	NNP
cord-018572-e2qq4ngq	20	36	al	al	NNP
cord-018572-e2qq4ngq	20	37	.	.	NNP
cord-018572-e2qq4ngq	20	38	1982	1982	CD
cord-018572-e2qq4ngq	20	39	)	)	-RRB-
cord-018572-e2qq4ngq	20	40	.	.	.
cord-018572-e2qq4ngq	21	1	Although	although	IN
cord-018572-e2qq4ngq	21	2	subsequent	subsequent	JJ
cord-018572-e2qq4ngq	21	3	studies	study	NNS
cord-018572-e2qq4ngq	21	4	led	lead	VBD
cord-018572-e2qq4ngq	21	5	to	to	IN
cord-018572-e2qq4ngq	21	6	the	the	DT
cord-018572-e2qq4ngq	21	7	discovery	discovery	NN
cord-018572-e2qq4ngq	21	8	that	that	IN
cord-018572-e2qq4ngq	21	9	the	the	DT
cord-018572-e2qq4ngq	21	10	major	major	JJ
cord-018572-e2qq4ngq	21	11	cellular	cellular	JJ
cord-018572-e2qq4ngq	21	12	function	function	NN
cord-018572-e2qq4ngq	21	13	of	of	IN
cord-018572-e2qq4ngq	21	14	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	21	15	is	be	VBZ
cord-018572-e2qq4ngq	21	16	regulation	regulation	NN
cord-018572-e2qq4ngq	21	17	of	of	IN
cord-018572-e2qq4ngq	21	18	membrane	membrane	NN
cord-018572-e2qq4ngq	21	19	trafficking	trafficking	NN
cord-018572-e2qq4ngq	21	20	,	,	,
cord-018572-e2qq4ngq	21	21	its	-PRON-	PRP$
cord-018572-e2qq4ngq	21	22	name	name	NN
cord-018572-e2qq4ngq	21	23	comes	come	VBZ
cord-018572-e2qq4ngq	21	24	from	from	IN
cord-018572-e2qq4ngq	21	25	this	this	DT
cord-018572-e2qq4ngq	21	26	initial	initial	JJ
cord-018572-e2qq4ngq	21	27	finding	finding	NN
cord-018572-e2qq4ngq	21	28	.	.	.
cord-018572-e2qq4ngq	22	1	The	the	DT
cord-018572-e2qq4ngq	22	2	original	original	JJ
cord-018572-e2qq4ngq	22	3	discovery	discovery	NN
cord-018572-e2qq4ngq	22	4	that	that	WDT
cord-018572-e2qq4ngq	22	5	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	22	6	has	have	VBZ
cord-018572-e2qq4ngq	22	7	an	an	DT
cord-018572-e2qq4ngq	22	8	essential	essential	JJ
cord-018572-e2qq4ngq	22	9	function	function	NN
cord-018572-e2qq4ngq	22	10	in	in	IN
cord-018572-e2qq4ngq	22	11	the	the	DT
cord-018572-e2qq4ngq	22	12	secretory	secretory	JJ
cord-018572-e2qq4ngq	22	13	pathway	pathway	NN
cord-018572-e2qq4ngq	22	14	at	at	IN
cord-018572-e2qq4ngq	22	15	the	the	DT
cord-018572-e2qq4ngq	22	16	level	level	NN
cord-018572-e2qq4ngq	22	17	of	of	IN
cord-018572-e2qq4ngq	22	18	the	the	DT
cord-018572-e2qq4ngq	22	19	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	22	20	came	come	VBD
cord-018572-e2qq4ngq	22	21	from	from	IN
cord-018572-e2qq4ngq	22	22	studies	study	NNS
cord-018572-e2qq4ngq	22	23	in	in	IN
cord-018572-e2qq4ngq	22	24	yeast	yeast	NN
cord-018572-e2qq4ngq	23	1	(	(	-LRB-
cord-018572-e2qq4ngq	23	2	Stearns	Stearns	NNP
cord-018572-e2qq4ngq	23	3	et	et	NNP
cord-018572-e2qq4ngq	23	4	al	al	NNP
cord-018572-e2qq4ngq	23	5	.	.	.
cord-018572-e2qq4ngq	24	1	1990a	1990a	CD
cord-018572-e2qq4ngq	24	2	,	,	,
cord-018572-e2qq4ngq	24	3	b	b	LS
cord-018572-e2qq4ngq	24	4	)	)	-RRB-
cord-018572-e2qq4ngq	24	5	.	.	.
cord-018572-e2qq4ngq	25	1	Soon	soon	RB
cord-018572-e2qq4ngq	25	2	thereafter	thereafter	RB
cord-018572-e2qq4ngq	25	3	,	,	,
cord-018572-e2qq4ngq	25	4	the	the	DT
cord-018572-e2qq4ngq	25	5	role	role	NN
cord-018572-e2qq4ngq	25	6	of	of	IN
cord-018572-e2qq4ngq	25	7	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	25	8	in	in	IN
cord-018572-e2qq4ngq	25	9	recruiting	recruit	VBG
cord-018572-e2qq4ngq	25	10	the	the	DT
cord-018572-e2qq4ngq	25	11	COPI	COPI	NNP
cord-018572-e2qq4ngq	25	12	coat	coat	NN
cord-018572-e2qq4ngq	25	13	complex	complex	JJ
cord-018572-e2qq4ngq	25	14	to	to	IN
cord-018572-e2qq4ngq	25	15	membranes	membrane	NNS
cord-018572-e2qq4ngq	25	16	of	of	IN
cord-018572-e2qq4ngq	25	17	the	the	DT
cord-018572-e2qq4ngq	25	18	early	early	JJ
cord-018572-e2qq4ngq	25	19	secretory	secretory	JJ
cord-018572-e2qq4ngq	25	20	pathway	pathway	NN
cord-018572-e2qq4ngq	25	21	to	to	TO
cord-018572-e2qq4ngq	25	22	mediate	mediate	VB
cord-018572-e2qq4ngq	25	23	COPI	COPI	NNP
cord-018572-e2qq4ngq	25	24	vesicle	vesicle	NN
cord-018572-e2qq4ngq	25	25	budding	budding	NN
cord-018572-e2qq4ngq	25	26	was	be	VBD
cord-018572-e2qq4ngq	25	27	demonstrated	demonstrate	VBN
cord-018572-e2qq4ngq	25	28	both	both	CC
cord-018572-e2qq4ngq	25	29	in	in	IN
cord-018572-e2qq4ngq	25	30	vitro	vitro	FW
cord-018572-e2qq4ngq	25	31	and	and	CC
cord-018572-e2qq4ngq	25	32	in	in	IN
cord-018572-e2qq4ngq	25	33	cells	cell	NNS
cord-018572-e2qq4ngq	25	34	.	.	.
cord-018572-e2qq4ngq	26	1	The	the	DT
cord-018572-e2qq4ngq	26	2	reconstitution	reconstitution	NN
cord-018572-e2qq4ngq	26	3	in	in	IN
cord-018572-e2qq4ngq	26	4	vitro	vitro	FW
cord-018572-e2qq4ngq	26	5	of	of	IN
cord-018572-e2qq4ngq	26	6	COPI	COPI	NNP
cord-018572-e2qq4ngq	26	7	vesicle	vesicle	NN
cord-018572-e2qq4ngq	26	8	budding	bud	VBG
cord-018572-e2qq4ngq	26	9	provided	provide	VBD
cord-018572-e2qq4ngq	26	10	important	important	JJ
cord-018572-e2qq4ngq	26	11	mechanistic	mechanistic	JJ
cord-018572-e2qq4ngq	26	12	insights	insight	NNS
cord-018572-e2qq4ngq	26	13	(	(	-LRB-
cord-018572-e2qq4ngq	26	14	Rothman	Rothman	NNP
cord-018572-e2qq4ngq	26	15	and	and	CC
cord-018572-e2qq4ngq	26	16	Wieland	Wieland	NNP
cord-018572-e2qq4ngq	26	17	1996	1996	CD
cord-018572-e2qq4ngq	26	18	)	)	-RRB-
cord-018572-e2qq4ngq	26	19	,	,	,
cord-018572-e2qq4ngq	26	20	and	and	CC
cord-018572-e2qq4ngq	26	21	the	the	DT
cord-018572-e2qq4ngq	26	22	function	function	NN
cord-018572-e2qq4ngq	26	23	of	of	IN
cord-018572-e2qq4ngq	26	24	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	26	25	in	in	IN
cord-018572-e2qq4ngq	26	26	cells	cell	NNS
cord-018572-e2qq4ngq	26	27	was	be	VBD
cord-018572-e2qq4ngq	26	28	greatly	greatly	RB
cord-018572-e2qq4ngq	26	29	aided	aid	VBN
cord-018572-e2qq4ngq	26	30	by	by	IN
cord-018572-e2qq4ngq	26	31	use	use	NN
cord-018572-e2qq4ngq	26	32	of	of	IN
cord-018572-e2qq4ngq	26	33	the	the	DT
cord-018572-e2qq4ngq	26	34	specific	specific	JJ
cord-018572-e2qq4ngq	26	35	inhibitor	inhibitor	NN
cord-018572-e2qq4ngq	26	36	of	of	IN
cord-018572-e2qq4ngq	26	37	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	26	38	activation	activation	NN
cord-018572-e2qq4ngq	26	39	,	,	,
cord-018572-e2qq4ngq	26	40	brefeldin	brefeldin	NNP
cord-018572-e2qq4ngq	26	41	A	A	NNP
cord-018572-e2qq4ngq	26	42	(	(	-LRB-
cord-018572-e2qq4ngq	26	43	Klausner	Klausner	NNP
cord-018572-e2qq4ngq	26	44	et	et	NNP
cord-018572-e2qq4ngq	26	45	al	al	NNP
cord-018572-e2qq4ngq	26	46	.	.	NNP
cord-018572-e2qq4ngq	26	47	1992	1992	CD
cord-018572-e2qq4ngq	26	48	)	)	-RRB-
cord-018572-e2qq4ngq	26	49	.	.	.
cord-018572-e2qq4ngq	27	1	Mammalian	mammalian	JJ
cord-018572-e2qq4ngq	27	2	Arf	Arf	NNP
cord-018572-e2qq4ngq	27	3	proteins	protein	NNS
cord-018572-e2qq4ngq	27	4	can	can	MD
cord-018572-e2qq4ngq	27	5	be	be	VB
cord-018572-e2qq4ngq	27	6	divided	divide	VBN
cord-018572-e2qq4ngq	27	7	into	into	IN
cord-018572-e2qq4ngq	27	8	three	three	CD
cord-018572-e2qq4ngq	27	9	classes	class	NNS
cord-018572-e2qq4ngq	27	10	based	base	VBN
cord-018572-e2qq4ngq	27	11	on	on	IN
cord-018572-e2qq4ngq	27	12	sequence	sequence	NN
cord-018572-e2qq4ngq	27	13	homology	homology	NN
cord-018572-e2qq4ngq	27	14	:	:	:
cord-018572-e2qq4ngq	27	15	Class	class	NN
cord-018572-e2qq4ngq	27	16	I	i	NN
cord-018572-e2qq4ngq	27	17	(	(	-LRB-
cord-018572-e2qq4ngq	27	18	Arfs1	Arfs1	NNP
cord-018572-e2qq4ngq	27	19	-	-	HYPH
cord-018572-e2qq4ngq	27	20	3	3	CD
cord-018572-e2qq4ngq	27	21	)	)	-RRB-
cord-018572-e2qq4ngq	27	22	,	,	,
cord-018572-e2qq4ngq	27	23	Class	Class	NNP
cord-018572-e2qq4ngq	27	24	II	II	NNP
cord-018572-e2qq4ngq	28	1	(	(	-LRB-
cord-018572-e2qq4ngq	28	2	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	28	3	4	4	CD
cord-018572-e2qq4ngq	28	4	-	-	SYM
cord-018572-e2qq4ngq	28	5	5	5	CD
cord-018572-e2qq4ngq	28	6	)	)	-RRB-
cord-018572-e2qq4ngq	28	7	,	,	,
cord-018572-e2qq4ngq	28	8	and	and	CC
cord-018572-e2qq4ngq	28	9	Class	Class	NNP
cord-018572-e2qq4ngq	28	10	III	III	NNP
cord-018572-e2qq4ngq	28	11	(	(	-LRB-
cord-018572-e2qq4ngq	28	12	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	28	13	)	)	-RRB-
cord-018572-e2qq4ngq	28	14	.	.	.
cord-018572-e2qq4ngq	29	1	Class	class	NN
cord-018572-e2qq4ngq	30	1	I	-PRON-	PRP
cord-018572-e2qq4ngq	30	2	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	30	3	are	be	VBP
cord-018572-e2qq4ngq	30	4	highly	highly	RB
cord-018572-e2qq4ngq	30	5	conserved	conserve	VBN
cord-018572-e2qq4ngq	30	6	and	and	CC
cord-018572-e2qq4ngq	30	7	are	be	VBP
cord-018572-e2qq4ngq	30	8	present	present	JJ
cord-018572-e2qq4ngq	30	9	in	in	IN
cord-018572-e2qq4ngq	30	10	all	all	DT
cord-018572-e2qq4ngq	30	11	eukaryotes	eukaryote	NNS
cord-018572-e2qq4ngq	30	12	,	,	,
cord-018572-e2qq4ngq	30	13	whereas	whereas	IN
cord-018572-e2qq4ngq	30	14	the	the	DT
cord-018572-e2qq4ngq	30	15	Class	Class	NNP
cord-018572-e2qq4ngq	30	16	II	II	NNP
cord-018572-e2qq4ngq	30	17	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	30	18	arose	arise	VBD
cord-018572-e2qq4ngq	30	19	during	during	IN
cord-018572-e2qq4ngq	30	20	animal	animal	NN
cord-018572-e2qq4ngq	30	21	cell	cell	NN
cord-018572-e2qq4ngq	30	22	evolution	evolution	NN
cord-018572-e2qq4ngq	30	23	,	,	,
cord-018572-e2qq4ngq	30	24	diverging	diverge	VBG
cord-018572-e2qq4ngq	30	25	from	from	IN
cord-018572-e2qq4ngq	30	26	the	the	DT
cord-018572-e2qq4ngq	30	27	Class	class	NN
cord-018572-e2qq4ngq	31	1	I	-PRON-	PRP
cord-018572-e2qq4ngq	31	2	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	31	3	in	in	IN
cord-018572-e2qq4ngq	31	4	the	the	DT
cord-018572-e2qq4ngq	31	5	animal	animal	NN
cord-018572-e2qq4ngq	31	6	lineage	lineage	NN
cord-018572-e2qq4ngq	31	7	after	after	IN
cord-018572-e2qq4ngq	31	8	fungi	fungus	NNS
cord-018572-e2qq4ngq	31	9	separated	separate	VBN
cord-018572-e2qq4ngq	31	10	,	,	,
cord-018572-e2qq4ngq	31	11	but	but	CC
cord-018572-e2qq4ngq	32	1	before	before	IN
cord-018572-e2qq4ngq	32	2	choanoflagellates	choanoflagellates	NNP
cord-018572-e2qq4ngq	32	3	did	do	VBD
cord-018572-e2qq4ngq	32	4	(	(	-LRB-
cord-018572-e2qq4ngq	32	5	Manolea	Manolea	NNP
cord-018572-e2qq4ngq	32	6	et	et	NNP
cord-018572-e2qq4ngq	32	7	al	al	NNP
cord-018572-e2qq4ngq	32	8	.	.	NNP
cord-018572-e2qq4ngq	32	9	2010	2010	CD
cord-018572-e2qq4ngq	32	10	;	;	:
cord-018572-e2qq4ngq	32	11	Schlacht	Schlacht	NNP
cord-018572-e2qq4ngq	32	12	et	et	FW
cord-018572-e2qq4ngq	32	13	al	al	NNP
cord-018572-e2qq4ngq	32	14	.	.	NNP
cord-018572-e2qq4ngq	32	15	2013	2013	CD
cord-018572-e2qq4ngq	32	16	)	)	-RRB-
cord-018572-e2qq4ngq	32	17	.	.	.
cord-018572-e2qq4ngq	33	1	Consequently	consequently	RB
cord-018572-e2qq4ngq	33	2	,	,	,
cord-018572-e2qq4ngq	33	3	in	in	IN
cord-018572-e2qq4ngq	33	4	all	all	DT
cord-018572-e2qq4ngq	33	5	invertebrates	invertebrate	NNS
cord-018572-e2qq4ngq	33	6	,	,	,
cord-018572-e2qq4ngq	33	7	such	such	JJ
cord-018572-e2qq4ngq	33	8	as	as	IN
cord-018572-e2qq4ngq	33	9	D.	D.	NNP
cord-018572-e2qq4ngq	33	10	melanogaster	melanogaster	NNP
cord-018572-e2qq4ngq	33	11	and	and	CC
cord-018572-e2qq4ngq	33	12	C.	C.	NNP
cord-018572-e2qq4ngq	33	13	elegans	elegan	NNS
cord-018572-e2qq4ngq	33	14	,	,	,
cord-018572-e2qq4ngq	33	15	there	there	EX
cord-018572-e2qq4ngq	33	16	is	be	VBZ
cord-018572-e2qq4ngq	33	17	one	one	CD
cord-018572-e2qq4ngq	33	18	member	member	NN
cord-018572-e2qq4ngq	33	19	of	of	IN
cord-018572-e2qq4ngq	33	20	each	each	DT
cord-018572-e2qq4ngq	33	21	of	of	IN
cord-018572-e2qq4ngq	33	22	the	the	DT
cord-018572-e2qq4ngq	33	23	three	three	CD
cord-018572-e2qq4ngq	33	24	Arf	Arf	NNP
cord-018572-e2qq4ngq	33	25	classes	class	NNS
cord-018572-e2qq4ngq	33	26	.	.	.
cord-018572-e2qq4ngq	34	1	In	in	IN
cord-018572-e2qq4ngq	34	2	certain	certain	JJ
cord-018572-e2qq4ngq	34	3	lineages	lineage	NNS
cord-018572-e2qq4ngq	34	4	,	,	,
cord-018572-e2qq4ngq	34	5	some	some	DT
cord-018572-e2qq4ngq	34	6	Arf	Arf	NNP
cord-018572-e2qq4ngq	34	7	classes	class	NNS
cord-018572-e2qq4ngq	34	8	have	have	VBP
cord-018572-e2qq4ngq	34	9	undergone	undergo	VBN
cord-018572-e2qq4ngq	34	10	expansion	expansion	NN
cord-018572-e2qq4ngq	34	11	.	.	.
cord-018572-e2qq4ngq	35	1	For	for	IN
cord-018572-e2qq4ngq	35	2	example	example	NN
cord-018572-e2qq4ngq	35	3	,	,	,
cord-018572-e2qq4ngq	35	4	vertebrates	vertebrate	NNS
cord-018572-e2qq4ngq	35	5	have	have	VBP
cord-018572-e2qq4ngq	35	6	multiple	multiple	JJ
cord-018572-e2qq4ngq	35	7	members	member	NNS
cord-018572-e2qq4ngq	35	8	of	of	IN
cord-018572-e2qq4ngq	35	9	Class	class	NN
cord-018572-e2qq4ngq	35	10	I	I	NNP
cord-018572-e2qq4ngq	35	11	and	and	CC
cord-018572-e2qq4ngq	35	12	II	II	NNP
cord-018572-e2qq4ngq	35	13	Arf	Arf	NNP
cord-018572-e2qq4ngq	35	14	proteins	protein	NNS
cord-018572-e2qq4ngq	36	1	(	(	-LRB-
cord-018572-e2qq4ngq	36	2	Li	Li	NNP
cord-018572-e2qq4ngq	36	3	et	et	NNP
cord-018572-e2qq4ngq	36	4	al	al	NNP
cord-018572-e2qq4ngq	36	5	.	.	.
cord-018572-e2qq4ngq	36	6	2004	2004	CD
cord-018572-e2qq4ngq	36	7	)	)	-RRB-
cord-018572-e2qq4ngq	36	8	.	.	.
cord-018572-e2qq4ngq	37	1	Although	although	IN
cord-018572-e2qq4ngq	37	2	yeast	yeast	NN
cord-018572-e2qq4ngq	37	3	lack	lack	NN
cord-018572-e2qq4ngq	37	4	Class	class	NN
cord-018572-e2qq4ngq	37	5	II	II	NNP
cord-018572-e2qq4ngq	37	6	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	37	7	,	,	,
cord-018572-e2qq4ngq	37	8	they	-PRON-	PRP
cord-018572-e2qq4ngq	37	9	have	have	VBP
cord-018572-e2qq4ngq	37	10	two	two	CD
cord-018572-e2qq4ngq	37	11	highly	highly	RB
cord-018572-e2qq4ngq	37	12	similar	similar	JJ
cord-018572-e2qq4ngq	37	13	Class	class	NN
cord-018572-e2qq4ngq	37	14	I	-PRON-	PRP
cord-018572-e2qq4ngq	37	15	Arf	arf	NN
cord-018572-e2qq4ngq	37	16	proteins	protein	NNS
cord-018572-e2qq4ngq	37	17	and	and	CC
cord-018572-e2qq4ngq	37	18	a	a	DT
cord-018572-e2qq4ngq	37	19	single	single	JJ
cord-018572-e2qq4ngq	37	20	Class	class	NN
cord-018572-e2qq4ngq	37	21	III	III	NNP
cord-018572-e2qq4ngq	37	22	member	member	NN
cord-018572-e2qq4ngq	37	23	.	.	.
cord-018572-e2qq4ngq	38	1	Plants	plant	NNS
cord-018572-e2qq4ngq	38	2	have	have	VBP
cord-018572-e2qq4ngq	38	3	numerous	numerous	JJ
cord-018572-e2qq4ngq	38	4	Class	class	NN
cord-018572-e2qq4ngq	39	1	I	-PRON-	PRP
cord-018572-e2qq4ngq	39	2	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	39	3	(	(	-LRB-
cord-018572-e2qq4ngq	39	4	six	six	CD
cord-018572-e2qq4ngq	39	5	in	in	IN
cord-018572-e2qq4ngq	39	6	Arabidopsis	Arabidopsis	NNP
cord-018572-e2qq4ngq	39	7	)	)	-RRB-
cord-018572-e2qq4ngq	40	1	that	that	WDT
cord-018572-e2qq4ngq	40	2	are	be	VBP
cord-018572-e2qq4ngq	40	3	all	all	RB
cord-018572-e2qq4ngq	40	4	more	more	RBR
cord-018572-e2qq4ngq	40	5	closely	closely	RB
cord-018572-e2qq4ngq	40	6	related	related	JJ
cord-018572-e2qq4ngq	40	7	to	to	IN
cord-018572-e2qq4ngq	40	8	each	each	DT
cord-018572-e2qq4ngq	40	9	other	other	JJ
cord-018572-e2qq4ngq	40	10	than	than	IN
cord-018572-e2qq4ngq	40	11	to	to	IN
cord-018572-e2qq4ngq	40	12	Class	class	NN
cord-018572-e2qq4ngq	41	1	I	-PRON-	PRP
cord-018572-e2qq4ngq	41	2	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	41	3	of	of	IN
cord-018572-e2qq4ngq	41	4	other	other	JJ
cord-018572-e2qq4ngq	41	5	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	41	6	supergroups	supergroup	NNS
cord-018572-e2qq4ngq	41	7	,	,	,
cord-018572-e2qq4ngq	41	8	as	as	RB
cord-018572-e2qq4ngq	41	9	well	well	RB
cord-018572-e2qq4ngq	41	10	as	as	IN
cord-018572-e2qq4ngq	41	11	highly	highly	RB
cord-018572-e2qq4ngq	41	12	diverged	diverge	VBN
cord-018572-e2qq4ngq	41	13	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	41	14	with	with	IN
cord-018572-e2qq4ngq	41	15	some	some	DT
cord-018572-e2qq4ngq	41	16	characteristics	characteristic	NNS
cord-018572-e2qq4ngq	41	17	of	of	IN
cord-018572-e2qq4ngq	41	18	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	41	19	Class	class	NN
cord-018572-e2qq4ngq	41	20	III	III	NNP
cord-018572-e2qq4ngq	41	21	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	41	22	(	(	-LRB-
cord-018572-e2qq4ngq	41	23	Gebbie	Gebbie	NNP
cord-018572-e2qq4ngq	41	24	et	et	FW
cord-018572-e2qq4ngq	41	25	al	al	NNP
cord-018572-e2qq4ngq	41	26	.	.	NNP
cord-018572-e2qq4ngq	41	27	2005	2005	CD
cord-018572-e2qq4ngq	41	28	)	)	-RRB-
cord-018572-e2qq4ngq	41	29	.	.	.
cord-018572-e2qq4ngq	42	1	The	the	DT
cord-018572-e2qq4ngq	42	2	Arf	Arf	NNP
cord-018572-e2qq4ngq	42	3	proteins	protein	NNS
cord-018572-e2qq4ngq	42	4	are	be	VBP
cord-018572-e2qq4ngq	42	5	part	part	NN
cord-018572-e2qq4ngq	42	6	of	of	IN
cord-018572-e2qq4ngq	42	7	a	a	DT
cord-018572-e2qq4ngq	42	8	larger	large	JJR
cord-018572-e2qq4ngq	42	9	family	family	NN
cord-018572-e2qq4ngq	42	10	that	that	WDT
cord-018572-e2qq4ngq	42	11	also	also	RB
cord-018572-e2qq4ngq	42	12	includes	include	VBZ
cord-018572-e2qq4ngq	42	13	the	the	DT
cord-018572-e2qq4ngq	42	14	Arf	Arf	NNP
cord-018572-e2qq4ngq	42	15	-	-	HYPH
cord-018572-e2qq4ngq	42	16	like	like	JJ
cord-018572-e2qq4ngq	42	17	(	(	-LRB-
cord-018572-e2qq4ngq	42	18	Arl	Arl	NNP
cord-018572-e2qq4ngq	42	19	)	)	-RRB-
cord-018572-e2qq4ngq	42	20	proteins	protein	NNS
cord-018572-e2qq4ngq	42	21	.	.	.
cord-018572-e2qq4ngq	43	1	There	there	EX
cord-018572-e2qq4ngq	43	2	are	be	VBP
cord-018572-e2qq4ngq	43	3	more	more	JJR
cord-018572-e2qq4ngq	43	4	than	than	IN
cord-018572-e2qq4ngq	43	5	20	20	CD
cord-018572-e2qq4ngq	43	6	Arl	Arl	NNP
cord-018572-e2qq4ngq	43	7	proteins	protein	NNS
cord-018572-e2qq4ngq	43	8	,	,	,
cord-018572-e2qq4ngq	43	9	with	with	IN
cord-018572-e2qq4ngq	43	10	a	a	DT
cord-018572-e2qq4ngq	43	11	wide	wide	JJ
cord-018572-e2qq4ngq	43	12	range	range	NN
cord-018572-e2qq4ngq	43	13	of	of	IN
cord-018572-e2qq4ngq	43	14	functions	function	NNS
cord-018572-e2qq4ngq	43	15	including	include	VBG
cord-018572-e2qq4ngq	43	16	membrane	membrane	NN
cord-018572-e2qq4ngq	43	17	trafficking	trafficking	NN
cord-018572-e2qq4ngq	43	18	,	,	,
cord-018572-e2qq4ngq	43	19	targeting	target	VBG
cord-018572-e2qq4ngq	43	20	of	of	IN
cord-018572-e2qq4ngq	43	21	proteins	protein	NNS
cord-018572-e2qq4ngq	43	22	to	to	IN
cord-018572-e2qq4ngq	43	23	cilia	cilium	NNS
cord-018572-e2qq4ngq	43	24	,	,	,
cord-018572-e2qq4ngq	43	25	microtubule	microtubule	NN
cord-018572-e2qq4ngq	43	26	regulation	regulation	NN
cord-018572-e2qq4ngq	43	27	,	,	,
cord-018572-e2qq4ngq	43	28	and	and	CC
cord-018572-e2qq4ngq	43	29	lysosome	lysosome	NN
cord-018572-e2qq4ngq	43	30	function	function	NN
cord-018572-e2qq4ngq	43	31	(	(	-LRB-
cord-018572-e2qq4ngq	43	32	Donaldson	Donaldson	NNP
cord-018572-e2qq4ngq	43	33	and	and	CC
cord-018572-e2qq4ngq	43	34	Jackson	Jackson	NNP
cord-018572-e2qq4ngq	43	35	2011	2011	CD
cord-018572-e2qq4ngq	43	36	;	;	:
cord-018572-e2qq4ngq	43	37	Gillingham	Gillingham	NNP
cord-018572-e2qq4ngq	43	38	and	and	CC
cord-018572-e2qq4ngq	43	39	Munro	Munro	NNP
cord-018572-e2qq4ngq	43	40	2007b	2007b	CD
cord-018572-e2qq4ngq	43	41	)	)	-RRB-
cord-018572-e2qq4ngq	43	42	.	.	.
cord-018572-e2qq4ngq	44	1	The	the	DT
cord-018572-e2qq4ngq	44	2	most	most	RBS
cord-018572-e2qq4ngq	44	3	divergent	divergent	JJ
cord-018572-e2qq4ngq	44	4	Arl	Arl	NNP
cord-018572-e2qq4ngq	44	5	protein	protein	NN
cord-018572-e2qq4ngq	44	6	is	be	VBZ
cord-018572-e2qq4ngq	44	7	Sar1	Sar1	NNP
cord-018572-e2qq4ngq	44	8	,	,	,
cord-018572-e2qq4ngq	44	9	an	an	DT
cord-018572-e2qq4ngq	44	10	evolutionarily	evolutionarily	RB
cord-018572-e2qq4ngq	44	11	ancient	ancient	JJ
cord-018572-e2qq4ngq	44	12	small	small	JJ
cord-018572-e2qq4ngq	44	13	G	g	NN
cord-018572-e2qq4ngq	44	14	protein	protein	NN
cord-018572-e2qq4ngq	44	15	that	that	WDT
cord-018572-e2qq4ngq	44	16	shares	share	VBZ
cord-018572-e2qq4ngq	44	17	a	a	DT
cord-018572-e2qq4ngq	44	18	highly	highly	RB
cord-018572-e2qq4ngq	44	19	related	relate	VBN
cord-018572-e2qq4ngq	44	20	function	function	NN
cord-018572-e2qq4ngq	44	21	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	44	22	cells	cell	NNS
cord-018572-e2qq4ngq	44	23	(	(	-LRB-
cord-018572-e2qq4ngq	44	24	Dacks	Dacks	NNPS
cord-018572-e2qq4ngq	44	25	and	and	CC
cord-018572-e2qq4ngq	44	26	Field	Field	NNP
cord-018572-e2qq4ngq	44	27	2007	2007	CD
cord-018572-e2qq4ngq	44	28	)	)	-RRB-
cord-018572-e2qq4ngq	44	29	.	.	.
cord-018572-e2qq4ngq	45	1	Intriguingly	intriguingly	RB
cord-018572-e2qq4ngq	45	2	,	,	,
cord-018572-e2qq4ngq	45	3	the	the	DT
cord-018572-e2qq4ngq	45	4	last	last	JJ
cord-018572-e2qq4ngq	45	5	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	45	6	common	common	JJ
cord-018572-e2qq4ngq	45	7	ancestor	ancestor	NN
cord-018572-e2qq4ngq	45	8	(	(	-LRB-
cord-018572-e2qq4ngq	45	9	LECA	LECA	NNP
cord-018572-e2qq4ngq	45	10	)	)	-RRB-
cord-018572-e2qq4ngq	45	11	likely	likely	RB
cord-018572-e2qq4ngq	45	12	possessed	possess	VBD
cord-018572-e2qq4ngq	45	13	only	only	RB
cord-018572-e2qq4ngq	45	14	one	one	CD
cord-018572-e2qq4ngq	45	15	Arf	Arf	NNP
cord-018572-e2qq4ngq	45	16	family	family	NN
cord-018572-e2qq4ngq	45	17	member	member	NN
cord-018572-e2qq4ngq	45	18	,	,	,
cord-018572-e2qq4ngq	45	19	in	in	IN
cord-018572-e2qq4ngq	45	20	contrast	contrast	NN
cord-018572-e2qq4ngq	45	21	to	to	IN
cord-018572-e2qq4ngq	45	22	having	have	VBG
cord-018572-e2qq4ngq	45	23	already	already	RB
cord-018572-e2qq4ngq	45	24	nearly	nearly	RB
cord-018572-e2qq4ngq	45	25	20	20	CD
cord-018572-e2qq4ngq	45	26	Rab	Rab	NNP
cord-018572-e2qq4ngq	45	27	proteins	protein	NNS
cord-018572-e2qq4ngq	45	28	(	(	-LRB-
cord-018572-e2qq4ngq	45	29	Koumandou	Koumandou	NNP
cord-018572-e2qq4ngq	45	30	et	et	NNP
cord-018572-e2qq4ngq	45	31	al	al	NNP
cord-018572-e2qq4ngq	45	32	.	.	NNP
cord-018572-e2qq4ngq	45	33	2013	2013	CD
cord-018572-e2qq4ngq	45	34	)	)	-RRB-
cord-018572-e2qq4ngq	45	35	.	.	.
cord-018572-e2qq4ngq	46	1	However	however	RB
cord-018572-e2qq4ngq	46	2	,	,	,
cord-018572-e2qq4ngq	46	3	multiple	multiple	JJ
cord-018572-e2qq4ngq	46	4	Arf	Arf	NNP
cord-018572-e2qq4ngq	46	5	GEFs	gefs	NN
cord-018572-e2qq4ngq	46	6	and	and	CC
cord-018572-e2qq4ngq	46	7	GAPs	GAPs	NNP
cord-018572-e2qq4ngq	46	8	existed	exist	VBD
cord-018572-e2qq4ngq	46	9	in	in	IN
cord-018572-e2qq4ngq	46	10	this	this	DT
cord-018572-e2qq4ngq	46	11	ancient	ancient	JJ
cord-018572-e2qq4ngq	46	12	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	46	13	ancestor	ancestor	NN
cord-018572-e2qq4ngq	46	14	,	,	,
cord-018572-e2qq4ngq	46	15	supporting	support	VBG
cord-018572-e2qq4ngq	46	16	the	the	DT
cord-018572-e2qq4ngq	46	17	idea	idea	NN
cord-018572-e2qq4ngq	46	18	that	that	IN
cord-018572-e2qq4ngq	46	19	a	a	DT
cord-018572-e2qq4ngq	46	20	key	key	JJ
cord-018572-e2qq4ngq	46	21	feature	feature	NN
cord-018572-e2qq4ngq	46	22	of	of	IN
cord-018572-e2qq4ngq	46	23	Arf	Arf	NNP
cord-018572-e2qq4ngq	46	24	function	function	NN
cord-018572-e2qq4ngq	46	25	is	be	VBZ
cord-018572-e2qq4ngq	46	26	a	a	DT
cord-018572-e2qq4ngq	46	27	single	single	JJ
cord-018572-e2qq4ngq	46	28	Arf	Arf	NNP
cord-018572-e2qq4ngq	46	29	protein	protein	NN
cord-018572-e2qq4ngq	46	30	participating	participate	VBG
cord-018572-e2qq4ngq	46	31	in	in	IN
cord-018572-e2qq4ngq	46	32	multiple	multiple	JJ
cord-018572-e2qq4ngq	46	33	GEF	GEF	NNP
cord-018572-e2qq4ngq	46	34	and	and	CC
cord-018572-e2qq4ngq	46	35	GAP	gap	NN
cord-018572-e2qq4ngq	46	36	regulatory	regulatory	JJ
cord-018572-e2qq4ngq	46	37	complexes	complex	NNS
cord-018572-e2qq4ngq	46	38	(	(	-LRB-
cord-018572-e2qq4ngq	46	39	Koumandou	Koumandou	NNP
cord-018572-e2qq4ngq	46	40	et	et	NNP
cord-018572-e2qq4ngq	46	41	al	al	NNP
cord-018572-e2qq4ngq	46	42	.	.	NNP
cord-018572-e2qq4ngq	46	43	2013	2013	CD
cord-018572-e2qq4ngq	46	44	;	;	:
cord-018572-e2qq4ngq	46	45	Schlacht	Schlacht	NNP
cord-018572-e2qq4ngq	46	46	et	et	FW
cord-018572-e2qq4ngq	46	47	al	al	NNP
cord-018572-e2qq4ngq	46	48	.	.	NNP
cord-018572-e2qq4ngq	46	49	2013	2013	CD
cord-018572-e2qq4ngq	46	50	)	)	-RRB-
cord-018572-e2qq4ngq	46	51	.	.	.
cord-018572-e2qq4ngq	47	1	This	this	DT
cord-018572-e2qq4ngq	47	2	feature	feature	NN
cord-018572-e2qq4ngq	47	3	is	be	VBZ
cord-018572-e2qq4ngq	47	4	conserved	conserve	VBN
cord-018572-e2qq4ngq	47	5	in	in	IN
cord-018572-e2qq4ngq	47	6	modern	modern	JJ
cord-018572-e2qq4ngq	47	7	organisms	organism	NNS
cord-018572-e2qq4ngq	47	8	,	,	,
cord-018572-e2qq4ngq	47	9	for	for	IN
cord-018572-e2qq4ngq	47	10	example	example	NN
cord-018572-e2qq4ngq	47	11	,	,	,
cord-018572-e2qq4ngq	47	12	in	in	IN
cord-018572-e2qq4ngq	47	13	humans	human	NNS
cord-018572-e2qq4ngq	47	14	,	,	,
cord-018572-e2qq4ngq	47	15	which	which	WDT
cord-018572-e2qq4ngq	47	16	have	have	VBP
cord-018572-e2qq4ngq	47	17	only	only	RB
cord-018572-e2qq4ngq	47	18	5	5	CD
cord-018572-e2qq4ngq	47	19	Arf	Arf	NNP
cord-018572-e2qq4ngq	47	20	proteins	protein	NNS
cord-018572-e2qq4ngq	47	21	,	,	,
cord-018572-e2qq4ngq	47	22	yet	yet	CC
cord-018572-e2qq4ngq	47	23	at	at	RB
cord-018572-e2qq4ngq	47	24	least	least	RBS
cord-018572-e2qq4ngq	47	25	15	15	CD
cord-018572-e2qq4ngq	47	26	GEFs	gef	NNS
cord-018572-e2qq4ngq	47	27	and	and	CC
cord-018572-e2qq4ngq	47	28	31	31	CD
cord-018572-e2qq4ngq	47	29	GAPs	gap	NNS
cord-018572-e2qq4ngq	47	30	.	.	.
cord-018572-e2qq4ngq	48	1	Perhaps	perhaps	RB
cord-018572-e2qq4ngq	48	2	a	a	DT
cord-018572-e2qq4ngq	48	3	clue	clue	NN
cord-018572-e2qq4ngq	48	4	as	as	IN
cord-018572-e2qq4ngq	48	5	to	to	IN
cord-018572-e2qq4ngq	48	6	the	the	DT
cord-018572-e2qq4ngq	48	7	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	48	8	TGN	TGN	NNP
cord-018572-e2qq4ngq	48	9	VxPx	VxPx	NNP
cord-018572-e2qq4ngq	48	10	targeting	target	VBG
cord-018572-e2qq4ngq	48	11	motif	motif	NN
cord-018572-e2qq4ngq	48	12	AP	AP	NNP
cord-018572-e2qq4ngq	48	13	adaptor	adaptor	NN
cord-018572-e2qq4ngq	48	14	protein	protein	NN
cord-018572-e2qq4ngq	48	15	,	,	,
cord-018572-e2qq4ngq	48	16	BAR	BAR	NNP
cord-018572-e2qq4ngq	48	17	Bin	Bin	NNP
cord-018572-e2qq4ngq	48	18	/	/	SYM
cord-018572-e2qq4ngq	48	19	Amphiphysin	Amphiphysin	NNP
cord-018572-e2qq4ngq	48	20	/	/	SYM
cord-018572-e2qq4ngq	48	21	Rvs	Rvs	NNP
cord-018572-e2qq4ngq	48	22	,	,	,
cord-018572-e2qq4ngq	48	23	CC	CC	NNP
cord-018572-e2qq4ngq	48	24	coiled	coil	VBN
cord-018572-e2qq4ngq	48	25	-	-	HYPH
cord-018572-e2qq4ngq	48	26	coil	coil	NN
cord-018572-e2qq4ngq	48	27	,	,	,
cord-018572-e2qq4ngq	48	28	COP	cop	NN
cord-018572-e2qq4ngq	48	29	coatomer	coatomer	NN
cord-018572-e2qq4ngq	48	30	protein	protein	NN
cord-018572-e2qq4ngq	48	31	,	,	,
cord-018572-e2qq4ngq	48	32	ER	ER	NNP
cord-018572-e2qq4ngq	48	33	endoplasmic	endoplasmic	NN
cord-018572-e2qq4ngq	48	34	reticulum	reticulum	NN
cord-018572-e2qq4ngq	48	35	,	,	,
cord-018572-e2qq4ngq	48	36	ERGIC	ERGIC	NNP
cord-018572-e2qq4ngq	48	37	ER	ER	NNP
cord-018572-e2qq4ngq	48	38	-	-	HYPH
cord-018572-e2qq4ngq	48	39	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	48	40	intermediate	intermediate	JJ
cord-018572-e2qq4ngq	48	41	compartment	compartment	NN
cord-018572-e2qq4ngq	48	42	,	,	,
cord-018572-e2qq4ngq	48	43	GAT	GAT	NNP
cord-018572-e2qq4ngq	48	44	GGA	GGA	NNP
cord-018572-e2qq4ngq	49	1	(	(	-LRB-
cord-018572-e2qq4ngq	49	2	Golgi	golgi	NN
cord-018572-e2qq4ngq	49	3	-	-	HYPH
cord-018572-e2qq4ngq	49	4	localized	localize	VBN
cord-018572-e2qq4ngq	49	5	,	,	,
cord-018572-e2qq4ngq	49	6	γ	γ	NN
cord-018572-e2qq4ngq	49	7	-	-	HYPH
cord-018572-e2qq4ngq	49	8	adaptin	adaptin	NNS
cord-018572-e2qq4ngq	49	9	homologous	homologous	JJ
cord-018572-e2qq4ngq	49	10	,	,	,
cord-018572-e2qq4ngq	49	11	ADP	ADP	NNP
cord-018572-e2qq4ngq	49	12	-	-	HYPH
cord-018572-e2qq4ngq	49	13	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	49	14	factor	factor	NN
cord-018572-e2qq4ngq	49	15	-	-	HYPH
cord-018572-e2qq4ngq	49	16	binding	bind	VBG
cord-018572-e2qq4ngq	49	17	protein	protein	NN
cord-018572-e2qq4ngq	49	18	)	)	-RRB-
cord-018572-e2qq4ngq	49	19	and	and	CC
cord-018572-e2qq4ngq	49	20	TOM1	TOM1	NNP
cord-018572-e2qq4ngq	49	21	homologous	homologous	JJ
cord-018572-e2qq4ngq	49	22	,	,	,
cord-018572-e2qq4ngq	49	23	GRAB	GRAB	NNP
cord-018572-e2qq4ngq	49	24	GRIP	grip	NN
cord-018572-e2qq4ngq	50	1	(	(	-LRB-
cord-018572-e2qq4ngq	50	2	golgin-97	golgin-97	NNS
cord-018572-e2qq4ngq	50	3	/	/	SYM
cord-018572-e2qq4ngq	50	4	RabBP2α	RabBP2α	NNP
cord-018572-e2qq4ngq	50	5	/	/	,
cord-018572-e2qq4ngq	50	6	Imh1p	Imh1p	NNP
cord-018572-e2qq4ngq	50	7	/	/	SYM
cord-018572-e2qq4ngq	50	8	p230)-related	p230)-relate	VBD
cord-018572-e2qq4ngq	50	9	Arf	Arf	NNP
cord-018572-e2qq4ngq	50	10	binding	binding	NN
cord-018572-e2qq4ngq	50	11	,	,	,
cord-018572-e2qq4ngq	50	12	PM	pm	NN
cord-018572-e2qq4ngq	50	13	plasma	plasma	NN
cord-018572-e2qq4ngq	50	14	membrane	membrane	NN
cord-018572-e2qq4ngq	50	15	,	,	,
cord-018572-e2qq4ngq	50	16	TGN	TGN	NNP
cord-018572-e2qq4ngq	50	17	trans	trans	NNP
cord-018572-e2qq4ngq	50	18	-	-	NNP
cord-018572-e2qq4ngq	50	19	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	50	20	network	network	NN
cord-018572-e2qq4ngq	50	21	;	;	:
cord-018572-e2qq4ngq	51	1	ND	ND	NNP
cord-018572-e2qq4ngq	51	2	,	,	,
cord-018572-e2qq4ngq	51	3	not	not	RB
cord-018572-e2qq4ngq	51	4	determined	determine	VBN
cord-018572-e2qq4ngq	51	5	nature	nature	NN
cord-018572-e2qq4ngq	51	6	of	of	IN
cord-018572-e2qq4ngq	51	7	the	the	DT
cord-018572-e2qq4ngq	51	8	primordial	primordial	JJ
cord-018572-e2qq4ngq	51	9	Arf	Arf	NNP
cord-018572-e2qq4ngq	51	10	protein	protein	NN
cord-018572-e2qq4ngq	51	11	comes	come	VBZ
cord-018572-e2qq4ngq	51	12	from	from	IN
cord-018572-e2qq4ngq	51	13	the	the	DT
cord-018572-e2qq4ngq	51	14	protozoan	protozoan	NN
cord-018572-e2qq4ngq	51	15	parasite	parasite	NN
cord-018572-e2qq4ngq	51	16	Trypanosoma	Trypanosoma	NNP
cord-018572-e2qq4ngq	51	17	brucei	brucei	NNP
cord-018572-e2qq4ngq	51	18	,	,	,
cord-018572-e2qq4ngq	51	19	which	which	WDT
cord-018572-e2qq4ngq	51	20	expresses	express	VBZ
cord-018572-e2qq4ngq	51	21	a	a	DT
cord-018572-e2qq4ngq	51	22	single	single	JJ
cord-018572-e2qq4ngq	51	23	Arf	Arf	NNP
cord-018572-e2qq4ngq	51	24	protein	protein	NN
cord-018572-e2qq4ngq	51	25	that	that	WDT
cord-018572-e2qq4ngq	51	26	has	have	VBZ
cord-018572-e2qq4ngq	51	27	characteristics	characteristic	NNS
cord-018572-e2qq4ngq	51	28	of	of	IN
cord-018572-e2qq4ngq	51	29	both	both	CC
cord-018572-e2qq4ngq	51	30	Class	Class	NNP
cord-018572-e2qq4ngq	51	31	I	I	NNP
cord-018572-e2qq4ngq	51	32	and	and	CC
cord-018572-e2qq4ngq	51	33	Class	Class	NNP
cord-018572-e2qq4ngq	51	34	III	III	NNP
cord-018572-e2qq4ngq	51	35	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	51	36	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	51	37	.	.	.
cord-018572-e2qq4ngq	52	1	TbArf1	tbarf1	PRP
cord-018572-e2qq4ngq	52	2	is	be	VBZ
cord-018572-e2qq4ngq	52	3	a	a	DT
cord-018572-e2qq4ngq	52	4	basic	basic	JJ
cord-018572-e2qq4ngq	52	5	protein	protein	NN
cord-018572-e2qq4ngq	52	6	with	with	IN
cord-018572-e2qq4ngq	52	7	a	a	DT
cord-018572-e2qq4ngq	52	8	high	high	JJ
cord-018572-e2qq4ngq	52	9	pI	pi	NN
cord-018572-e2qq4ngq	52	10	similar	similar	JJ
cord-018572-e2qq4ngq	52	11	to	to	IN
cord-018572-e2qq4ngq	52	12	that	that	DT
cord-018572-e2qq4ngq	52	13	of	of	IN
cord-018572-e2qq4ngq	52	14	human	human	JJ
cord-018572-e2qq4ngq	52	15	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	52	16	,	,	,
cord-018572-e2qq4ngq	52	17	but	but	CC
cord-018572-e2qq4ngq	52	18	contains	contain	VBZ
cord-018572-e2qq4ngq	52	19	the	the	DT
cord-018572-e2qq4ngq	52	20	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	52	21	-	-	HYPH
cord-018572-e2qq4ngq	52	22	targeting	target	VBG
cord-018572-e2qq4ngq	52	23	motif	motif	NN
cord-018572-e2qq4ngq	52	24	MxxE	MxxE	NNP
cord-018572-e2qq4ngq	53	1	(	(	-LRB-
cord-018572-e2qq4ngq	53	2	Price	price	NN
cord-018572-e2qq4ngq	53	3	et	et	NNP
cord-018572-e2qq4ngq	53	4	al	al	NNP
cord-018572-e2qq4ngq	53	5	.	.	NNP
cord-018572-e2qq4ngq	53	6	2007	2007	CD
cord-018572-e2qq4ngq	53	7	)	)	-RRB-
cord-018572-e2qq4ngq	53	8	,	,	,
cord-018572-e2qq4ngq	53	9	found	find	VBN
cord-018572-e2qq4ngq	53	10	in	in	IN
cord-018572-e2qq4ngq	53	11	human	human	JJ
cord-018572-e2qq4ngq	53	12	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	53	13	and	and	CC
cord-018572-e2qq4ngq	53	14	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	53	15	(	(	-LRB-
cord-018572-e2qq4ngq	53	16	Honda	Honda	NNP
cord-018572-e2qq4ngq	53	17	et	et	NNP
cord-018572-e2qq4ngq	53	18	al	al	NNP
cord-018572-e2qq4ngq	53	19	.	.	NNP
cord-018572-e2qq4ngq	53	20	2005	2005	CD
cord-018572-e2qq4ngq	53	21	)	)	-RRB-
cord-018572-e2qq4ngq	53	22	.	.	.
cord-018572-e2qq4ngq	54	1	TbArf1	tbarf1	PRP
cord-018572-e2qq4ngq	54	2	localizes	localize	VBZ
cord-018572-e2qq4ngq	54	3	to	to	IN
cord-018572-e2qq4ngq	54	4	the	the	DT
cord-018572-e2qq4ngq	54	5	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	54	6	,	,	,
cord-018572-e2qq4ngq	54	7	and	and	CC
cord-018572-e2qq4ngq	54	8	functional	functional	JJ
cord-018572-e2qq4ngq	54	9	studies	study	NNS
cord-018572-e2qq4ngq	54	10	indicate	indicate	VBP
cord-018572-e2qq4ngq	54	11	that	that	IN
cord-018572-e2qq4ngq	54	12	it	-PRON-	PRP
cord-018572-e2qq4ngq	54	13	has	have	VBZ
cord-018572-e2qq4ngq	54	14	roles	role	NNS
cord-018572-e2qq4ngq	54	15	in	in	IN
cord-018572-e2qq4ngq	54	16	both	both	DT
cord-018572-e2qq4ngq	54	17	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	54	18	and	and	CC
cord-018572-e2qq4ngq	54	19	in	in	IN
cord-018572-e2qq4ngq	54	20	Golgi	golgi	NN
cord-018572-e2qq4ngq	54	21	-	-	HYPH
cord-018572-e2qq4ngq	54	22	lysosome	lysosome	NN
cord-018572-e2qq4ngq	54	23	trafficking	trafficking	NN
cord-018572-e2qq4ngq	54	24	(	(	-LRB-
cord-018572-e2qq4ngq	54	25	Price	price	NN
cord-018572-e2qq4ngq	54	26	et	et	FW
cord-018572-e2qq4ngq	54	27	al	al	NNP
cord-018572-e2qq4ngq	54	28	.	.	NNP
cord-018572-e2qq4ngq	54	29	2007	2007	CD
cord-018572-e2qq4ngq	54	30	)	)	-RRB-
cord-018572-e2qq4ngq	54	31	.	.	.
cord-018572-e2qq4ngq	55	1	The	the	DT
cord-018572-e2qq4ngq	55	2	spatiotemporal	spatiotemporal	JJ
cord-018572-e2qq4ngq	55	3	control	control	NN
cord-018572-e2qq4ngq	55	4	of	of	IN
cord-018572-e2qq4ngq	55	5	Arf	Arf	NNP
cord-018572-e2qq4ngq	55	6	protein	protein	NN
cord-018572-e2qq4ngq	55	7	function	function	NN
cord-018572-e2qq4ngq	55	8	is	be	VBZ
cord-018572-e2qq4ngq	55	9	mediated	mediate	VBN
cord-018572-e2qq4ngq	55	10	by	by	IN
cord-018572-e2qq4ngq	55	11	regulators	regulator	NNS
cord-018572-e2qq4ngq	55	12	of	of	IN
cord-018572-e2qq4ngq	55	13	Arf	Arf	NNP
cord-018572-e2qq4ngq	55	14	GTP	GTP	NNP
cord-018572-e2qq4ngq	55	15	binding	bind	VBG
cord-018572-e2qq4ngq	55	16	and	and	CC
cord-018572-e2qq4ngq	55	17	GTP	GTP	NNP
cord-018572-e2qq4ngq	55	18	hydrolysis	hydrolysis	NN
cord-018572-e2qq4ngq	56	1	(	(	-LRB-
cord-018572-e2qq4ngq	56	2	Fig	Fig	NNP
cord-018572-e2qq4ngq	56	3	.	.	.
cord-018572-e2qq4ngq	56	4	8.1d	8.1d	CD
cord-018572-e2qq4ngq	56	5	)	)	-RRB-
cord-018572-e2qq4ngq	56	6	.	.	.
cord-018572-e2qq4ngq	57	1	The	the	DT
cord-018572-e2qq4ngq	57	2	Arf	Arf	NNP
cord-018572-e2qq4ngq	57	3	guanine	guanine	NN
cord-018572-e2qq4ngq	57	4	nucleotideexchange	nucleotideexchange	NN
cord-018572-e2qq4ngq	57	5	factors	factor	NNS
cord-018572-e2qq4ngq	57	6	(	(	-LRB-
cord-018572-e2qq4ngq	57	7	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	57	8	)	)	-RRB-
cord-018572-e2qq4ngq	57	9	catalyse	catalyse	VB
cord-018572-e2qq4ngq	57	10	GDP	gdp	NN
cord-018572-e2qq4ngq	57	11	release	release	NN
cord-018572-e2qq4ngq	57	12	from	from	IN
cord-018572-e2qq4ngq	57	13	their	-PRON-	PRP$
cord-018572-e2qq4ngq	57	14	substrate	substrate	NN
cord-018572-e2qq4ngq	57	15	Arf	Arf	NNP
cord-018572-e2qq4ngq	57	16	,	,	,
cord-018572-e2qq4ngq	57	17	allowing	allow	VBG
cord-018572-e2qq4ngq	57	18	GTP	GTP	NNP
cord-018572-e2qq4ngq	57	19	,	,	,
cord-018572-e2qq4ngq	57	20	which	which	WDT
cord-018572-e2qq4ngq	57	21	is	be	VBZ
cord-018572-e2qq4ngq	57	22	more	more	RBR
cord-018572-e2qq4ngq	57	23	abundant	abundant	JJ
cord-018572-e2qq4ngq	57	24	in	in	IN
cord-018572-e2qq4ngq	57	25	cells	cell	NNS
cord-018572-e2qq4ngq	57	26	,	,	,
cord-018572-e2qq4ngq	57	27	to	to	TO
cord-018572-e2qq4ngq	57	28	bind	bind	VB
cord-018572-e2qq4ngq	57	29	.	.	.
cord-018572-e2qq4ngq	58	1	This	this	DT
cord-018572-e2qq4ngq	58	2	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	58	3	-	-	HYPH
cord-018572-e2qq4ngq	58	4	exchange	exchange	NN
cord-018572-e2qq4ngq	58	5	activity	activity	NN
cord-018572-e2qq4ngq	58	6	is	be	VBZ
cord-018572-e2qq4ngq	58	7	carried	carry	VBN
cord-018572-e2qq4ngq	58	8	out	out	RP
cord-018572-e2qq4ngq	58	9	by	by	IN
cord-018572-e2qq4ngq	58	10	the	the	DT
cord-018572-e2qq4ngq	58	11	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	58	12	domain	domain	NN
cord-018572-e2qq4ngq	58	13	,	,	,
cord-018572-e2qq4ngq	58	14	a	a	DT
cord-018572-e2qq4ngq	58	15	highly	highly	RB
cord-018572-e2qq4ngq	58	16	evolutionarily	evolutionarily	RB
cord-018572-e2qq4ngq	58	17	conserved	conserved	JJ
cord-018572-e2qq4ngq	58	18	domain	domain	NN
cord-018572-e2qq4ngq	58	19	first	first	RB
cord-018572-e2qq4ngq	58	20	identified	identify	VBN
cord-018572-e2qq4ngq	58	21	as	as	IN
cord-018572-e2qq4ngq	58	22	a	a	DT
cord-018572-e2qq4ngq	58	23	homology	homology	NN
cord-018572-e2qq4ngq	58	24	domain	domain	NN
cord-018572-e2qq4ngq	58	25	in	in	IN
cord-018572-e2qq4ngq	58	26	the	the	DT
cord-018572-e2qq4ngq	58	27	yeast	yeast	NN
cord-018572-e2qq4ngq	58	28	Sec7p	Sec7p	NNP
cord-018572-e2qq4ngq	58	29	protein	protein	NN
cord-018572-e2qq4ngq	58	30	,	,	,
cord-018572-e2qq4ngq	58	31	and	and	CC
cord-018572-e2qq4ngq	58	32	whose	whose	WP$
cord-018572-e2qq4ngq	58	33	function	function	NN
cord-018572-e2qq4ngq	58	34	was	be	VBD
cord-018572-e2qq4ngq	58	35	first	first	RB
cord-018572-e2qq4ngq	58	36	identified	identify	VBN
cord-018572-e2qq4ngq	58	37	in	in	IN
cord-018572-e2qq4ngq	58	38	the	the	DT
cord-018572-e2qq4ngq	58	39	yeast	yeast	NN
cord-018572-e2qq4ngq	58	40	Gea1p	gea1p	NN
cord-018572-e2qq4ngq	58	41	protein	protein	NN
cord-018572-e2qq4ngq	58	42	(	(	-LRB-
cord-018572-e2qq4ngq	58	43	Peyroche	Peyroche	NNP
cord-018572-e2qq4ngq	58	44	et	et	NNP
cord-018572-e2qq4ngq	58	45	al	al	NNP
cord-018572-e2qq4ngq	58	46	.	.	.
cord-018572-e2qq4ngq	58	47	1996	1996	CD
cord-018572-e2qq4ngq	58	48	)	)	-RRB-
cord-018572-e2qq4ngq	58	49	.	.	.
cord-018572-e2qq4ngq	59	1	A	a	DT
cord-018572-e2qq4ngq	59	2	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	59	3	domain	domain	NN
cord-018572-e2qq4ngq	59	4	is	be	VBZ
cord-018572-e2qq4ngq	59	5	present	present	JJ
cord-018572-e2qq4ngq	59	6	in	in	IN
cord-018572-e2qq4ngq	59	7	all	all	DT
cord-018572-e2qq4ngq	59	8	Arf	Arf	NNP
cord-018572-e2qq4ngq	59	9	GEFs	gef	NNS
cord-018572-e2qq4ngq	59	10	identified	identify	VBN
cord-018572-e2qq4ngq	59	11	to	to	IN
cord-018572-e2qq4ngq	59	12	date	date	NN
cord-018572-e2qq4ngq	59	13	.	.	.
cord-018572-e2qq4ngq	60	1	The	the	DT
cord-018572-e2qq4ngq	60	2	Arf	Arf	NNP
cord-018572-e2qq4ngq	60	3	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	60	4	activating	activate	VBG
cord-018572-e2qq4ngq	60	5	proteins	protein	NNS
cord-018572-e2qq4ngq	60	6	(	(	-LRB-
cord-018572-e2qq4ngq	60	7	GAPs	GAPs	NNP
cord-018572-e2qq4ngq	60	8	)	)	-RRB-
cord-018572-e2qq4ngq	60	9	catalyse	catalyse	VB
cord-018572-e2qq4ngq	60	10	the	the	DT
cord-018572-e2qq4ngq	60	11	hydrolysis	hydrolysis	NN
cord-018572-e2qq4ngq	60	12	of	of	IN
cord-018572-e2qq4ngq	60	13	GTP	GTP	NNP
cord-018572-e2qq4ngq	60	14	on	on	IN
cord-018572-e2qq4ngq	60	15	their	-PRON-	PRP$
cord-018572-e2qq4ngq	60	16	substrate	substrate	NN
cord-018572-e2qq4ngq	60	17	Arf	Arf	NNP
cord-018572-e2qq4ngq	60	18	,	,	,
cord-018572-e2qq4ngq	60	19	a	a	DT
cord-018572-e2qq4ngq	60	20	function	function	NN
cord-018572-e2qq4ngq	60	21	carried	carry	VBN
cord-018572-e2qq4ngq	60	22	out	out	RP
cord-018572-e2qq4ngq	60	23	by	by	IN
cord-018572-e2qq4ngq	60	24	a	a	DT
cord-018572-e2qq4ngq	60	25	conserved	conserve	VBN
cord-018572-e2qq4ngq	60	26	GAP	gap	NN
cord-018572-e2qq4ngq	60	27	domain	domain	NN
cord-018572-e2qq4ngq	60	28	,	,	,
cord-018572-e2qq4ngq	60	29	characterized	characterize	VBN
cord-018572-e2qq4ngq	60	30	by	by	IN
cord-018572-e2qq4ngq	60	31	the	the	DT
cord-018572-e2qq4ngq	60	32	presence	presence	NN
cord-018572-e2qq4ngq	60	33	of	of	IN
cord-018572-e2qq4ngq	60	34	a	a	DT
cord-018572-e2qq4ngq	60	35	zinc	zinc	NN
cord-018572-e2qq4ngq	60	36	finger	finger	NN
cord-018572-e2qq4ngq	60	37	.	.	.
cord-018572-e2qq4ngq	61	1	The	the	DT
cord-018572-e2qq4ngq	61	2	Arf	Arf	NNP
cord-018572-e2qq4ngq	61	3	GAPs	gaps	NN
cord-018572-e2qq4ngq	61	4	are	be	VBP
cord-018572-e2qq4ngq	61	5	essential	essential	JJ
cord-018572-e2qq4ngq	61	6	because	because	IN
cord-018572-e2qq4ngq	61	7	Arf	Arf	NNP
cord-018572-e2qq4ngq	61	8	proteins	protein	NNS
cord-018572-e2qq4ngq	61	9	have	have	VBP
cord-018572-e2qq4ngq	61	10	negligible	negligible	JJ
cord-018572-e2qq4ngq	61	11	intrinsic	intrinsic	JJ
cord-018572-e2qq4ngq	61	12	GTP	gtp	NN
cord-018572-e2qq4ngq	61	13	hydrolysis	hydrolysis	NN
cord-018572-e2qq4ngq	61	14	activity	activity	NN
cord-018572-e2qq4ngq	61	15	(	(	-LRB-
cord-018572-e2qq4ngq	61	16	Kahn	Kahn	NNP
cord-018572-e2qq4ngq	61	17	and	and	CC
cord-018572-e2qq4ngq	61	18	Gilman	Gilman	NNP
cord-018572-e2qq4ngq	61	19	1986	1986	CD
cord-018572-e2qq4ngq	61	20	)	)	-RRB-
cord-018572-e2qq4ngq	61	21	.	.	.
cord-018572-e2qq4ngq	62	1	The	the	DT
cord-018572-e2qq4ngq	62	2	primary	primary	JJ
cord-018572-e2qq4ngq	62	3	sequence	sequence	NN
cord-018572-e2qq4ngq	62	4	homology	homology	NN
cord-018572-e2qq4ngq	62	5	of	of	IN
cord-018572-e2qq4ngq	62	6	the	the	DT
cord-018572-e2qq4ngq	62	7	catalytic	catalytic	JJ
cord-018572-e2qq4ngq	62	8	domains	domain	NNS
cord-018572-e2qq4ngq	62	9	of	of	IN
cord-018572-e2qq4ngq	62	10	the	the	DT
cord-018572-e2qq4ngq	62	11	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	62	12	and	and	CC
cord-018572-e2qq4ngq	62	13	GAPs	GAPs	NNP
cord-018572-e2qq4ngq	62	14	facilitated	facilitate	VBD
cord-018572-e2qq4ngq	62	15	their	-PRON-	PRP$
cord-018572-e2qq4ngq	62	16	identification	identification	NN
cord-018572-e2qq4ngq	62	17	,	,	,
cord-018572-e2qq4ngq	62	18	but	but	CC
cord-018572-e2qq4ngq	62	19	their	-PRON-	PRP$
cord-018572-e2qq4ngq	62	20	Arf	Arf	NNP
cord-018572-e2qq4ngq	62	21	substrate	substrate	NN
cord-018572-e2qq4ngq	62	22	specificity	specificity	NN
cord-018572-e2qq4ngq	62	23	has	have	VBZ
cord-018572-e2qq4ngq	62	24	not	not	RB
cord-018572-e2qq4ngq	62	25	been	be	VBN
cord-018572-e2qq4ngq	62	26	fully	fully	RB
cord-018572-e2qq4ngq	62	27	elucidated	elucidate	VBN
cord-018572-e2qq4ngq	62	28	.	.	.
cord-018572-e2qq4ngq	63	1	A	a	DT
cord-018572-e2qq4ngq	63	2	recent	recent	JJ
cord-018572-e2qq4ngq	63	3	study	study	NN
cord-018572-e2qq4ngq	63	4	of	of	IN
cord-018572-e2qq4ngq	63	5	the	the	DT
cord-018572-e2qq4ngq	63	6	Arf	Arf	NNP
cord-018572-e2qq4ngq	63	7	GAPs	gaps	NN
cord-018572-e2qq4ngq	63	8	has	have	VBZ
cord-018572-e2qq4ngq	63	9	revealed	reveal	VBN
cord-018572-e2qq4ngq	63	10	that	that	IN
cord-018572-e2qq4ngq	63	11	they	-PRON-	PRP
cord-018572-e2qq4ngq	63	12	have	have	VBP
cord-018572-e2qq4ngq	63	13	likely	likely	RB
cord-018572-e2qq4ngq	63	14	co	co	VBN
cord-018572-e2qq4ngq	63	15	-	-	VBN
cord-018572-e2qq4ngq	63	16	evolved	evolved	JJ
cord-018572-e2qq4ngq	63	17	with	with	IN
cord-018572-e2qq4ngq	63	18	their	-PRON-	PRP$
cord-018572-e2qq4ngq	63	19	Arf	Arf	NNP
cord-018572-e2qq4ngq	63	20	substrates	substrate	NNS
cord-018572-e2qq4ngq	63	21	(	(	-LRB-
cord-018572-e2qq4ngq	63	22	Schlacht	Schlacht	NNP
cord-018572-e2qq4ngq	63	23	et	et	FW
cord-018572-e2qq4ngq	63	24	al	al	NNP
cord-018572-e2qq4ngq	63	25	.	.	NNP
cord-018572-e2qq4ngq	63	26	2013	2013	CD
cord-018572-e2qq4ngq	63	27	)	)	-RRB-
cord-018572-e2qq4ngq	63	28	.	.	.
cord-018572-e2qq4ngq	64	1	These	these	DT
cord-018572-e2qq4ngq	64	2	results	result	NNS
cord-018572-e2qq4ngq	64	3	support	support	VBP
cord-018572-e2qq4ngq	64	4	the	the	DT
cord-018572-e2qq4ngq	64	5	conclusion	conclusion	NN
cord-018572-e2qq4ngq	64	6	that	that	IN
cord-018572-e2qq4ngq	64	7	the	the	DT
cord-018572-e2qq4ngq	64	8	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	64	9	function	function	NN
cord-018572-e2qq4ngq	64	10	in	in	IN
cord-018572-e2qq4ngq	64	11	a	a	DT
cord-018572-e2qq4ngq	64	12	tightly	tightly	RB
cord-018572-e2qq4ngq	64	13	coordinated	coordinate	VBN
cord-018572-e2qq4ngq	64	14	manner	manner	NN
cord-018572-e2qq4ngq	64	15	with	with	IN
cord-018572-e2qq4ngq	64	16	their	-PRON-	PRP$
cord-018572-e2qq4ngq	64	17	regulators	regulator	NNS
cord-018572-e2qq4ngq	64	18	.	.	.
cord-018572-e2qq4ngq	65	1	There	there	EX
cord-018572-e2qq4ngq	65	2	are	be	VBP
cord-018572-e2qq4ngq	65	3	seven	seven	CD
cord-018572-e2qq4ngq	65	4	subfamilies	subfamily	NNS
cord-018572-e2qq4ngq	65	5	of	of	IN
cord-018572-e2qq4ngq	65	6	Arf	Arf	NNP
cord-018572-e2qq4ngq	65	7	GEFs	gefs	NN
cord-018572-e2qq4ngq	65	8	in	in	IN
cord-018572-e2qq4ngq	65	9	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	65	10	cells	cell	NNS
cord-018572-e2qq4ngq	65	11	(	(	-LRB-
cord-018572-e2qq4ngq	65	12	Cox	Cox	NNP
cord-018572-e2qq4ngq	65	13	et	et	NNP
cord-018572-e2qq4ngq	65	14	al	al	NNP
cord-018572-e2qq4ngq	65	15	.	.	.
cord-018572-e2qq4ngq	65	16	2004	2004	CD
cord-018572-e2qq4ngq	65	17	)	)	-RRB-
cord-018572-e2qq4ngq	66	1	(	(	-LRB-
cord-018572-e2qq4ngq	66	2	Table	table	NN
cord-018572-e2qq4ngq	66	3	8	8	CD
cord-018572-e2qq4ngq	66	4	.2	.2	CD
cord-018572-e2qq4ngq	66	5	,	,	,
cord-018572-e2qq4ngq	66	6	Fig	Fig	NNP
cord-018572-e2qq4ngq	66	7	.	.	.
cord-018572-e2qq4ngq	67	1	8	8	CD
cord-018572-e2qq4ngq	67	2	.2	.2	CD
cord-018572-e2qq4ngq	67	3	)	)	-RRB-
cord-018572-e2qq4ngq	67	4	.	.	.
cord-018572-e2qq4ngq	68	1	The	the	DT
cord-018572-e2qq4ngq	68	2	GBF	GBF	NNP
cord-018572-e2qq4ngq	68	3	/	/	SYM
cord-018572-e2qq4ngq	68	4	Gea	Gea	NNP
cord-018572-e2qq4ngq	68	5	and	and	CC
cord-018572-e2qq4ngq	68	6	BIG	BIG	NNP
cord-018572-e2qq4ngq	68	7	/	/	SYM
cord-018572-e2qq4ngq	68	8	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	68	9	GEFs	gef	NNS
cord-018572-e2qq4ngq	68	10	are	be	VBP
cord-018572-e2qq4ngq	68	11	localized	localize	VBN
cord-018572-e2qq4ngq	68	12	to	to	IN
cord-018572-e2qq4ngq	68	13	the	the	DT
cord-018572-e2qq4ngq	68	14	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	68	15	,	,	,
cord-018572-e2qq4ngq	68	16	and	and	CC
cord-018572-e2qq4ngq	68	17	use	use	VB
cord-018572-e2qq4ngq	68	18	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	68	19	as	as	IN
cord-018572-e2qq4ngq	68	20	a	a	DT
cord-018572-e2qq4ngq	68	21	substrate	substrate	NN
cord-018572-e2qq4ngq	68	22	(	(	-LRB-
cord-018572-e2qq4ngq	68	23	Donaldson	Donaldson	NNP
cord-018572-e2qq4ngq	68	24	and	and	CC
cord-018572-e2qq4ngq	68	25	Jackson	Jackson	NNP
cord-018572-e2qq4ngq	68	26	2011	2011	CD
cord-018572-e2qq4ngq	68	27	)	)	-RRB-
cord-018572-e2qq4ngq	68	28	.	.	.
cord-018572-e2qq4ngq	69	1	In	in	IN
cord-018572-e2qq4ngq	69	2	animal	animal	NN
cord-018572-e2qq4ngq	69	3	cells	cell	NNS
cord-018572-e2qq4ngq	69	4	and	and	CC
cord-018572-e2qq4ngq	69	5	yeast	yeast	NN
cord-018572-e2qq4ngq	69	6	,	,	,
cord-018572-e2qq4ngq	69	7	these	these	DT
cord-018572-e2qq4ngq	69	8	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	69	9	act	act	VBP
cord-018572-e2qq4ngq	69	10	sequentially	sequentially	RB
cord-018572-e2qq4ngq	69	11	,	,	,
cord-018572-e2qq4ngq	69	12	with	with	IN
cord-018572-e2qq4ngq	69	13	GBF	GBF	NNP
cord-018572-e2qq4ngq	69	14	/	/	SYM
cord-018572-e2qq4ngq	69	15	Gea	Gea	NNP
cord-018572-e2qq4ngq	69	16	proteins	protein	NNS
cord-018572-e2qq4ngq	69	17	functioning	function	VBG
cord-018572-e2qq4ngq	69	18	at	at	IN
cord-018572-e2qq4ngq	69	19	the	the	DT
cord-018572-e2qq4ngq	69	20	early	early	JJ
cord-018572-e2qq4ngq	69	21	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	69	22	,	,	,
cord-018572-e2qq4ngq	69	23	and	and	CC
cord-018572-e2qq4ngq	69	24	BIG	big	JJ
cord-018572-e2qq4ngq	69	25	/	/	SYM
cord-018572-e2qq4ngq	69	26	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	69	27	proteins	protein	NNS
cord-018572-e2qq4ngq	69	28	at	at	IN
cord-018572-e2qq4ngq	69	29	the	the	DT
cord-018572-e2qq4ngq	69	30	trans	trans	NNP
cord-018572-e2qq4ngq	69	31	-	-	NNP
cord-018572-e2qq4ngq	69	32	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	69	33	and	and	CC
cord-018572-e2qq4ngq	69	34	trans	trans	NNP
cord-018572-e2qq4ngq	69	35	-	-	JJ
cord-018572-e2qq4ngq	69	36	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	69	37	network	network	NN
cord-018572-e2qq4ngq	69	38	(	(	-LRB-
cord-018572-e2qq4ngq	69	39	TGN	TGN	NNP
cord-018572-e2qq4ngq	69	40	)	)	-RRB-
cord-018572-e2qq4ngq	70	1	(	(	-LRB-
cord-018572-e2qq4ngq	70	2	Franzusoff	Franzusoff	NNP
cord-018572-e2qq4ngq	70	3	et	et	NNP
cord-018572-e2qq4ngq	70	4	al	al	NNP
cord-018572-e2qq4ngq	70	5	.	.	.
cord-018572-e2qq4ngq	71	1	1991	1991	CD
cord-018572-e2qq4ngq	71	2	;	;	:
cord-018572-e2qq4ngq	71	3	Peyroche	Peyroche	NNP
cord-018572-e2qq4ngq	71	4	et	et	NNP
cord-018572-e2qq4ngq	71	5	al	al	NNP
cord-018572-e2qq4ngq	71	6	.	.	.
cord-018572-e2qq4ngq	72	1	2001	2001	CD
cord-018572-e2qq4ngq	72	2	;	;	:
cord-018572-e2qq4ngq	72	3	Zhao	Zhao	NNP
cord-018572-e2qq4ngq	72	4	et	et	NNP
cord-018572-e2qq4ngq	72	5	al	al	NNP
cord-018572-e2qq4ngq	72	6	.	.	.
cord-018572-e2qq4ngq	72	7	2002	2002	CD
cord-018572-e2qq4ngq	72	8	)	)	-RRB-
cord-018572-e2qq4ngq	72	9	.	.	.
cord-018572-e2qq4ngq	73	1	The	the	DT
cord-018572-e2qq4ngq	73	2	cytohesin/	cytohesin/	NNP
cord-018572-e2qq4ngq	73	3	Arno	Arno	NNP
cord-018572-e2qq4ngq	73	4	,	,	,
cord-018572-e2qq4ngq	73	5	EFA6	EFA6	NNP
cord-018572-e2qq4ngq	73	6	,	,	,
cord-018572-e2qq4ngq	73	7	and	and	CC
cord-018572-e2qq4ngq	73	8	IQSEC	IQSEC	NNP
cord-018572-e2qq4ngq	73	9	/	/	SYM
cord-018572-e2qq4ngq	73	10	BRAG	brag	VBP
cord-018572-e2qq4ngq	73	11	subfamilies	subfamily	NNS
cord-018572-e2qq4ngq	73	12	function	function	VBP
cord-018572-e2qq4ngq	73	13	primarily	primarily	RB
cord-018572-e2qq4ngq	73	14	in	in	IN
cord-018572-e2qq4ngq	73	15	endosomal	endosomal	NNP
cord-018572-e2qq4ngq	73	16	-	-	HYPH
cord-018572-e2qq4ngq	73	17	PM	pm	NN
cord-018572-e2qq4ngq	73	18	trafficking	traffic	VBG
cord-018572-e2qq4ngq	73	19	pathways	pathway	NNS
cord-018572-e2qq4ngq	73	20	at	at	IN
cord-018572-e2qq4ngq	73	21	the	the	DT
cord-018572-e2qq4ngq	73	22	cell	cell	NN
cord-018572-e2qq4ngq	73	23	periphery	periphery	NN
cord-018572-e2qq4ngq	73	24	,	,	,
cord-018572-e2qq4ngq	73	25	and	and	CC
cord-018572-e2qq4ngq	73	26	primarily	primarily	RB
cord-018572-e2qq4ngq	73	27	act	act	VB
cord-018572-e2qq4ngq	73	28	on	on	IN
cord-018572-e2qq4ngq	73	29	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	73	30	(	(	-LRB-
cord-018572-e2qq4ngq	73	31	Casanova	Casanova	NNP
cord-018572-e2qq4ngq	73	32	2007	2007	CD
cord-018572-e2qq4ngq	73	33	;	;	:
cord-018572-e2qq4ngq	74	1	Cox	Cox	NNP
cord-018572-e2qq4ngq	74	2	et	et	NNP
cord-018572-e2qq4ngq	74	3	al	al	NNP
cord-018572-e2qq4ngq	74	4	.	.	.
cord-018572-e2qq4ngq	75	1	2004	2004	CD
cord-018572-e2qq4ngq	75	2	;	;	:
cord-018572-e2qq4ngq	75	3	Gillingham	Gillingham	NNP
cord-018572-e2qq4ngq	75	4	and	and	CC
cord-018572-e2qq4ngq	75	5	Munro	Munro	NNP
cord-018572-e2qq4ngq	75	6	2007b	2007b	CD
cord-018572-e2qq4ngq	75	7	)	)	-RRB-
cord-018572-e2qq4ngq	75	8	.	.	.
cord-018572-e2qq4ngq	76	1	The	the	DT
cord-018572-e2qq4ngq	76	2	EFA6	EFA6	NNP
cord-018572-e2qq4ngq	76	3	GEFs	gefs	NN
cord-018572-e2qq4ngq	76	4	regulate	regulate	VBP
cord-018572-e2qq4ngq	76	5	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	76	6	,	,	,
cord-018572-e2qq4ngq	76	7	endosomal	endosomal	NNP
cord-018572-e2qq4ngq	76	8	membrane	membrane	NN
cord-018572-e2qq4ngq	76	9	recycling	recycling	NN
cord-018572-e2qq4ngq	76	10	,	,	,
cord-018572-e2qq4ngq	76	11	and	and	CC
cord-018572-e2qq4ngq	76	12	actin	actin	NN
cord-018572-e2qq4ngq	76	13	cytoskeleton	cytoskeleton	NN
cord-018572-e2qq4ngq	76	14	remodelling	remodelling	NN
cord-018572-e2qq4ngq	76	15	(	(	-LRB-
cord-018572-e2qq4ngq	76	16	Casanova	Casanova	NNP
cord-018572-e2qq4ngq	76	17	2007	2007	CD
cord-018572-e2qq4ngq	76	18	;	;	:
cord-018572-e2qq4ngq	76	19	Franco	Franco	NNP
cord-018572-e2qq4ngq	76	20	et	et	NNP
cord-018572-e2qq4ngq	76	21	al	al	NNP
cord-018572-e2qq4ngq	76	22	.	.	.
cord-018572-e2qq4ngq	76	23	1999	1999	CD
cord-018572-e2qq4ngq	76	24	)	)	-RRB-
cord-018572-e2qq4ngq	76	25	.	.	.
cord-018572-e2qq4ngq	77	1	Yel1p	Yel1p	NNP
cord-018572-e2qq4ngq	77	2	is	be	VBZ
cord-018572-e2qq4ngq	77	3	the	the	DT
cord-018572-e2qq4ngq	77	4	orthologue	orthologue	NN
cord-018572-e2qq4ngq	77	5	of	of	IN
cord-018572-e2qq4ngq	77	6	EFA6	EFA6	NNP
cord-018572-e2qq4ngq	77	7	in	in	IN
cord-018572-e2qq4ngq	77	8	budding	bud	VBG
cord-018572-e2qq4ngq	77	9	yeast	yeast	NN
cord-018572-e2qq4ngq	77	10	,	,	,
cord-018572-e2qq4ngq	77	11	Saccharomyces	Saccharomyces	NNP
cord-018572-e2qq4ngq	77	12	cerevisiae	cerevisiae	NNS
cord-018572-e2qq4ngq	77	13	,	,	,
cord-018572-e2qq4ngq	77	14	exhibiting	exhibit	VBG
cord-018572-e2qq4ngq	77	15	exchange	exchange	NN
cord-018572-e2qq4ngq	77	16	activity	activity	NN
cord-018572-e2qq4ngq	77	17	in	in	IN
cord-018572-e2qq4ngq	77	18	vitro	vitro	FW
cord-018572-e2qq4ngq	77	19	on	on	IN
cord-018572-e2qq4ngq	77	20	Arf3p	Arf3p	NNP
cord-018572-e2qq4ngq	77	21	(	(	-LRB-
cord-018572-e2qq4ngq	77	22	the	the	DT
cord-018572-e2qq4ngq	77	23	yeast	yeast	NN
cord-018572-e2qq4ngq	77	24	Class	Class	NNP
cord-018572-e2qq4ngq	77	25	III	III	NNP
cord-018572-e2qq4ngq	77	26	member	member	NN
cord-018572-e2qq4ngq	77	27	)	)	-RRB-
cord-018572-e2qq4ngq	77	28	(	(	-LRB-
cord-018572-e2qq4ngq	77	29	Gillingham	Gillingham	NNP
cord-018572-e2qq4ngq	77	30	and	and	CC
cord-018572-e2qq4ngq	77	31	Munro	Munro	NNP
cord-018572-e2qq4ngq	77	32	2007a	2007a	CD
cord-018572-e2qq4ngq	77	33	)	)	-RRB-
cord-018572-e2qq4ngq	77	34	,	,	,
cord-018572-e2qq4ngq	77	35	which	which	WDT
cord-018572-e2qq4ngq	77	36	is	be	VBZ
cord-018572-e2qq4ngq	77	37	involved	involve	VBN
cord-018572-e2qq4ngq	77	38	in	in	IN
cord-018572-e2qq4ngq	77	39	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	77	40	(	(	-LRB-
cord-018572-e2qq4ngq	77	41	Smaczynska	Smaczynska	NNP
cord-018572-e2qq4ngq	77	42	-	-	HYPH
cord-018572-e2qq4ngq	77	43	de	de	NNP
cord-018572-e2qq4ngq	77	44	Rooij	Rooij	NNP
cord-018572-e2qq4ngq	77	45	et	et	FW
cord-018572-e2qq4ngq	77	46	al	al	NNP
cord-018572-e2qq4ngq	77	47	.	.	NNP
cord-018572-e2qq4ngq	77	48	2008	2008	CD
cord-018572-e2qq4ngq	77	49	)	)	-RRB-
cord-018572-e2qq4ngq	77	50	.	.	.
cord-018572-e2qq4ngq	78	1	Yel1p	Yel1p	NNP
cord-018572-e2qq4ngq	78	2	has	have	VBZ
cord-018572-e2qq4ngq	78	3	a	a	DT
cord-018572-e2qq4ngq	78	4	homology	homology	NN
cord-018572-e2qq4ngq	78	5	domain	domain	NN
cord-018572-e2qq4ngq	78	6	in	in	IN
cord-018572-e2qq4ngq	78	7	the	the	DT
cord-018572-e2qq4ngq	78	8	C	C	NNP
cord-018572-e2qq4ngq	78	9	-	-	HYPH
cord-018572-e2qq4ngq	78	10	terminus	terminus	NN
cord-018572-e2qq4ngq	78	11	resembling	resembling	NN
cord-018572-e2qq4ngq	78	12	that	that	DT
cord-018572-e2qq4ngq	78	13	of	of	IN
cord-018572-e2qq4ngq	78	14	EFA6	EFA6	NNP
cord-018572-e2qq4ngq	78	15	family	family	NN
cord-018572-e2qq4ngq	78	16	members	member	NNS
cord-018572-e2qq4ngq	78	17	(	(	-LRB-
cord-018572-e2qq4ngq	78	18	Gillingham	Gillingham	NNP
cord-018572-e2qq4ngq	78	19	and	and	CC
cord-018572-e2qq4ngq	78	20	Munro	Munro	NNP
cord-018572-e2qq4ngq	78	21	2007a	2007a	CD
cord-018572-e2qq4ngq	78	22	)	)	-RRB-
cord-018572-e2qq4ngq	78	23	.	.	.
cord-018572-e2qq4ngq	79	1	Syt1p	Syt1p	NNP
cord-018572-e2qq4ngq	79	2	has	have	VBZ
cord-018572-e2qq4ngq	79	3	a	a	DT
cord-018572-e2qq4ngq	79	4	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	79	5	domain	domain	NN
cord-018572-e2qq4ngq	79	6	that	that	WDT
cord-018572-e2qq4ngq	79	7	most	most	RBS
cord-018572-e2qq4ngq	79	8	closely	closely	RB
cord-018572-e2qq4ngq	79	9	resembles	resemble	VBZ
cord-018572-e2qq4ngq	79	10	that	that	DT
cord-018572-e2qq4ngq	79	11	of	of	IN
cord-018572-e2qq4ngq	79	12	the	the	DT
cord-018572-e2qq4ngq	79	13	IQSEC/	IQSEC/	NNP
cord-018572-e2qq4ngq	79	14	BRAG	brag	VBP
cord-018572-e2qq4ngq	79	15	family	family	NN
cord-018572-e2qq4ngq	79	16	in	in	IN
cord-018572-e2qq4ngq	79	17	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	79	18	cells	cell	NNS
cord-018572-e2qq4ngq	79	19	,	,	,
cord-018572-e2qq4ngq	79	20	although	although	IN
cord-018572-e2qq4ngq	79	21	it	-PRON-	PRP
cord-018572-e2qq4ngq	79	22	lacks	lack	VBZ
cord-018572-e2qq4ngq	79	23	an	an	DT
cord-018572-e2qq4ngq	79	24	IQ	iq	NN
cord-018572-e2qq4ngq	79	25	motif	motif	NN
cord-018572-e2qq4ngq	79	26	(	(	-LRB-
cord-018572-e2qq4ngq	79	27	Cox	Cox	NNP
cord-018572-e2qq4ngq	79	28	et	et	NNP
cord-018572-e2qq4ngq	79	29	al	al	NNP
cord-018572-e2qq4ngq	79	30	.	.	.
cord-018572-e2qq4ngq	79	31	2004	2004	CD
cord-018572-e2qq4ngq	79	32	)	)	-RRB-
cord-018572-e2qq4ngq	79	33	,	,	,
cord-018572-e2qq4ngq	79	34	and	and	CC
cord-018572-e2qq4ngq	79	35	functions	function	NNS
cord-018572-e2qq4ngq	79	36	with	with	IN
cord-018572-e2qq4ngq	79	37	Arl3p	Arl3p	NNP
cord-018572-e2qq4ngq	79	38	and	and	CC
cord-018572-e2qq4ngq	79	39	Arl1p	arl1p	RB
cord-018572-e2qq4ngq	79	40	at	at	IN
cord-018572-e2qq4ngq	79	41	the	the	DT
cord-018572-e2qq4ngq	79	42	trans	trans	NNP
cord-018572-e2qq4ngq	79	43	-	-	NNP
cord-018572-e2qq4ngq	79	44	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	79	45	in	in	IN
cord-018572-e2qq4ngq	79	46	yeast	yeast	NN
cord-018572-e2qq4ngq	79	47	.	.	.
cord-018572-e2qq4ngq	80	1	The	the	DT
cord-018572-e2qq4ngq	80	2	FBXO8	fbxo8	NN
cord-018572-e2qq4ngq	80	3	Arf	Arf	NNP
cord-018572-e2qq4ngq	80	4	GEFs	gef	NNS
cord-018572-e2qq4ngq	80	5	contain	contain	VBP
cord-018572-e2qq4ngq	80	6	an	an	DT
cord-018572-e2qq4ngq	80	7	F	F	NNP
cord-018572-e2qq4ngq	80	8	-	-	HYPH
cord-018572-e2qq4ngq	80	9	box	box	NN
cord-018572-e2qq4ngq	80	10	in	in	IN
cord-018572-e2qq4ngq	80	11	addition	addition	NN
cord-018572-e2qq4ngq	80	12	to	to	IN
cord-018572-e2qq4ngq	80	13	the	the	DT
cord-018572-e2qq4ngq	80	14	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	80	15	domain	domain	NN
cord-018572-e2qq4ngq	80	16	,	,	,
cord-018572-e2qq4ngq	80	17	and	and	CC
cord-018572-e2qq4ngq	80	18	are	be	VBP
cord-018572-e2qq4ngq	80	19	present	present	JJ
cord-018572-e2qq4ngq	80	20	in	in	IN
cord-018572-e2qq4ngq	80	21	vertebrates	vertebrate	NNS
cord-018572-e2qq4ngq	80	22	,	,	,
cord-018572-e2qq4ngq	80	23	and	and	CC
cord-018572-e2qq4ngq	80	24	at	at	RB
cord-018572-e2qq4ngq	80	25	least	least	RBS
cord-018572-e2qq4ngq	80	26	one	one	CD
cord-018572-e2qq4ngq	80	27	invertebrate	invertebrate	NN
cord-018572-e2qq4ngq	80	28	(	(	-LRB-
cord-018572-e2qq4ngq	80	29	Gillingham	Gillingham	NNP
cord-018572-e2qq4ngq	80	30	and	and	CC
cord-018572-e2qq4ngq	80	31	Munro	Munro	NNP
cord-018572-e2qq4ngq	80	32	2007b	2007b	CD
cord-018572-e2qq4ngq	80	33	)	)	-RRB-
cord-018572-e2qq4ngq	80	34	,	,	,
cord-018572-e2qq4ngq	80	35	but	but	CC
cord-018572-e2qq4ngq	80	36	are	be	VBP
cord-018572-e2qq4ngq	80	37	not	not	RB
cord-018572-e2qq4ngq	80	38	present	present	JJ
cord-018572-e2qq4ngq	80	39	in	in	IN
cord-018572-e2qq4ngq	80	40	yeast	yeast	NN
cord-018572-e2qq4ngq	80	41	,	,	,
cord-018572-e2qq4ngq	80	42	worms	worm	NNS
cord-018572-e2qq4ngq	80	43	,	,	,
cord-018572-e2qq4ngq	80	44	or	or	CC
cord-018572-e2qq4ngq	80	45	flies	fly	NNS
cord-018572-e2qq4ngq	80	46	.	.	.
cord-018572-e2qq4ngq	81	1	Little	little	JJ
cord-018572-e2qq4ngq	81	2	is	be	VBZ
cord-018572-e2qq4ngq	81	3	known	know	VBN
cord-018572-e2qq4ngq	81	4	of	of	IN
cord-018572-e2qq4ngq	81	5	its	-PRON-	PRP$
cord-018572-e2qq4ngq	81	6	function	function	NN
cord-018572-e2qq4ngq	81	7	,	,	,
cord-018572-e2qq4ngq	81	8	although	although	IN
cord-018572-e2qq4ngq	81	9	--recently	--recently	RB
cord-018572-e2qq4ngq	81	10	a	a	DT
cord-018572-e2qq4ngq	81	11	form	form	NN
cord-018572-e2qq4ngq	81	12	of	of	IN
cord-018572-e2qq4ngq	81	13	bilateral	bilateral	JJ
cord-018572-e2qq4ngq	81	14	cleft	cleft	NN
cord-018572-e2qq4ngq	81	15	lip	lip	NN
cord-018572-e2qq4ngq	81	16	has	have	VBZ
cord-018572-e2qq4ngq	81	17	been	be	VBN
cord-018572-e2qq4ngq	81	18	associated	associate	VBN
cord-018572-e2qq4ngq	81	19	with	with	IN
cord-018572-e2qq4ngq	81	20	a	a	DT
cord-018572-e2qq4ngq	81	21	deletion	deletion	NN
cord-018572-e2qq4ngq	81	22	of	of	IN
cord-018572-e2qq4ngq	81	23	a	a	DT
cord-018572-e2qq4ngq	81	24	chromosomal	chromosomal	JJ
cord-018572-e2qq4ngq	81	25	region	region	NN
cord-018572-e2qq4ngq	81	26	including	include	VBG
cord-018572-e2qq4ngq	81	27	the	the	DT
cord-018572-e2qq4ngq	81	28	FBXO8	fbxo8	NN
cord-018572-e2qq4ngq	81	29	gene	gene	NN
cord-018572-e2qq4ngq	81	30	(	(	-LRB-
cord-018572-e2qq4ngq	81	31	Calcia	Calcia	NNP
cord-018572-e2qq4ngq	81	32	et	et	FW
cord-018572-e2qq4ngq	81	33	al	al	NNP
cord-018572-e2qq4ngq	81	34	.	.	NNP
cord-018572-e2qq4ngq	81	35	2013	2013	CD
cord-018572-e2qq4ngq	81	36	)	)	-RRB-
cord-018572-e2qq4ngq	81	37	.	.	.
cord-018572-e2qq4ngq	82	1	RalF	RalF	NNP
cord-018572-e2qq4ngq	82	2	is	be	VBZ
cord-018572-e2qq4ngq	82	3	the	the	DT
cord-018572-e2qq4ngq	82	4	founding	found	VBG
cord-018572-e2qq4ngq	82	5	member	member	NN
cord-018572-e2qq4ngq	82	6	of	of	IN
cord-018572-e2qq4ngq	82	7	a	a	DT
cord-018572-e2qq4ngq	82	8	family	family	NN
cord-018572-e2qq4ngq	82	9	of	of	IN
cord-018572-e2qq4ngq	82	10	bacterial	bacterial	JJ
cord-018572-e2qq4ngq	82	11	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	82	12	GEFs	gefs	NN
cord-018572-e2qq4ngq	82	13	,	,	,
cord-018572-e2qq4ngq	82	14	first	first	RB
cord-018572-e2qq4ngq	82	15	identified	identify	VBN
cord-018572-e2qq4ngq	82	16	in	in	IN
cord-018572-e2qq4ngq	82	17	Legionella	Legionella	NNP
cord-018572-e2qq4ngq	82	18	pneumophila	pneumophila	NN
cord-018572-e2qq4ngq	82	19	and	and	CC
cord-018572-e2qq4ngq	82	20	Rickettsia	Rickettsia	NNP
cord-018572-e2qq4ngq	82	21	prowazekii	prowazekii	NNS
cord-018572-e2qq4ngq	82	22	(	(	-LRB-
cord-018572-e2qq4ngq	82	23	Amor	Amor	NNP
cord-018572-e2qq4ngq	82	24	et	et	NNP
cord-018572-e2qq4ngq	82	25	al	al	NNP
cord-018572-e2qq4ngq	82	26	.	.	NNP
cord-018572-e2qq4ngq	82	27	2005	2005	CD
cord-018572-e2qq4ngq	82	28	;	;	:
cord-018572-e2qq4ngq	82	29	Cox	Cox	NNP
cord-018572-e2qq4ngq	82	30	et	et	NNP
cord-018572-e2qq4ngq	82	31	al	al	NNP
cord-018572-e2qq4ngq	82	32	.	.	.
cord-018572-e2qq4ngq	82	33	2004	2004	CD
cord-018572-e2qq4ngq	82	34	)	)	-RRB-
cord-018572-e2qq4ngq	82	35	.	.	.
cord-018572-e2qq4ngq	83	1	These	these	DT
cord-018572-e2qq4ngq	83	2	GEFs	gef	NNS
cord-018572-e2qq4ngq	83	3	do	do	VBP
cord-018572-e2qq4ngq	83	4	not	not	RB
cord-018572-e2qq4ngq	83	5	have	have	VB
cord-018572-e2qq4ngq	83	6	a	a	DT
cord-018572-e2qq4ngq	83	7	prokaryotic	prokaryotic	JJ
cord-018572-e2qq4ngq	83	8	origin	origin	NN
cord-018572-e2qq4ngq	83	9	,	,	,
cord-018572-e2qq4ngq	83	10	but	but	CC
cord-018572-e2qq4ngq	83	11	rather	rather	RB
cord-018572-e2qq4ngq	83	12	were	be	VBD
cord-018572-e2qq4ngq	83	13	incorporated	incorporate	VBN
cord-018572-e2qq4ngq	83	14	into	into	IN
cord-018572-e2qq4ngq	83	15	bacterial	bacterial	JJ
cord-018572-e2qq4ngq	83	16	genomes	genome	NNS
cord-018572-e2qq4ngq	83	17	through	through	IN
cord-018572-e2qq4ngq	83	18	horizontal	horizontal	JJ
cord-018572-e2qq4ngq	83	19	transfer	transfer	NN
cord-018572-e2qq4ngq	83	20	from	from	IN
cord-018572-e2qq4ngq	83	21	their	-PRON-	PRP$
cord-018572-e2qq4ngq	83	22	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	83	23	hosts	host	NNS
cord-018572-e2qq4ngq	83	24	(	(	-LRB-
cord-018572-e2qq4ngq	83	25	Nagai	Nagai	NNP
cord-018572-e2qq4ngq	83	26	et	et	NNP
cord-018572-e2qq4ngq	83	27	al	al	NNP
cord-018572-e2qq4ngq	83	28	.	.	.
cord-018572-e2qq4ngq	83	29	2002	2002	CD
cord-018572-e2qq4ngq	83	30	)	)	-RRB-
cord-018572-e2qq4ngq	83	31	.	.	.
cord-018572-e2qq4ngq	84	1	The	the	DT
cord-018572-e2qq4ngq	84	2	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	84	3	domain	domain	NN
cord-018572-e2qq4ngq	84	4	of	of	IN
cord-018572-e2qq4ngq	84	5	RalF	RalF	NNP
cord-018572-e2qq4ngq	84	6	is	be	VBZ
cord-018572-e2qq4ngq	84	7	autoinhibited	autoinhibite	VBN
cord-018572-e2qq4ngq	84	8	by	by	IN
cord-018572-e2qq4ngq	84	9	the	the	DT
cord-018572-e2qq4ngq	84	10	capping	cap	VBG
cord-018572-e2qq4ngq	84	11	domain	domain	NN
cord-018572-e2qq4ngq	84	12	of	of	IN
cord-018572-e2qq4ngq	84	13	the	the	DT
cord-018572-e2qq4ngq	84	14	protein	protein	NN
cord-018572-e2qq4ngq	84	15	,	,	,
cord-018572-e2qq4ngq	84	16	which	which	WDT
cord-018572-e2qq4ngq	84	17	is	be	VBZ
cord-018572-e2qq4ngq	84	18	relieved	relieve	VBN
cord-018572-e2qq4ngq	84	19	by	by	IN
cord-018572-e2qq4ngq	84	20	interaction	interaction	NN
cord-018572-e2qq4ngq	84	21	with	with	IN
cord-018572-e2qq4ngq	84	22	a	a	DT
cord-018572-e2qq4ngq	84	23	specific	specific	JJ
cord-018572-e2qq4ngq	84	24	lipid	lipid	NN
cord-018572-e2qq4ngq	84	25	environment	environment	NN
cord-018572-e2qq4ngq	84	26	(	(	-LRB-
cord-018572-e2qq4ngq	84	27	Alix	Alix	NNP
cord-018572-e2qq4ngq	84	28	et	et	NNP
cord-018572-e2qq4ngq	84	29	al	al	NNP
cord-018572-e2qq4ngq	84	30	.	.	.
cord-018572-e2qq4ngq	85	1	2012	2012	CD
cord-018572-e2qq4ngq	85	2	;	;	:
cord-018572-e2qq4ngq	85	3	Folly	Folly	NNP
cord-018572-e2qq4ngq	85	4	-	-	HYPH
cord-018572-e2qq4ngq	85	5	Klan	Klan	NNP
cord-018572-e2qq4ngq	85	6	et	et	NNP
cord-018572-e2qq4ngq	85	7	al	al	NNP
cord-018572-e2qq4ngq	85	8	.	.	NNP
cord-018572-e2qq4ngq	85	9	2013	2013	CD
cord-018572-e2qq4ngq	85	10	)	)	-RRB-
cord-018572-e2qq4ngq	85	11	.	.	.
cord-018572-e2qq4ngq	86	1	There	there	EX
cord-018572-e2qq4ngq	86	2	are	be	VBP
cord-018572-e2qq4ngq	86	3	11	11	CD
cord-018572-e2qq4ngq	86	4	subfamilies	subfamily	NNS
cord-018572-e2qq4ngq	86	5	of	of	IN
cord-018572-e2qq4ngq	86	6	Arf	Arf	NNP
cord-018572-e2qq4ngq	86	7	GAPs	gaps	NN
cord-018572-e2qq4ngq	86	8	,	,	,
cord-018572-e2qq4ngq	86	9	10	10	CD
cord-018572-e2qq4ngq	86	10	of	of	IN
cord-018572-e2qq4ngq	86	11	which	which	WDT
cord-018572-e2qq4ngq	86	12	are	be	VBP
cord-018572-e2qq4ngq	86	13	found	find	VBN
cord-018572-e2qq4ngq	86	14	in	in	IN
cord-018572-e2qq4ngq	86	15	humans	human	NNS
cord-018572-e2qq4ngq	86	16	(	(	-LRB-
cord-018572-e2qq4ngq	86	17	Schlacht	Schlacht	NNP
cord-018572-e2qq4ngq	86	18	et	et	FW
cord-018572-e2qq4ngq	86	19	al	al	NNP
cord-018572-e2qq4ngq	86	20	.	.	NNP
cord-018572-e2qq4ngq	86	21	2013	2013	CD
cord-018572-e2qq4ngq	86	22	)	)	-RRB-
cord-018572-e2qq4ngq	87	1	(	(	-LRB-
cord-018572-e2qq4ngq	87	2	Table	table	NN
cord-018572-e2qq4ngq	87	3	8	8	CD
cord-018572-e2qq4ngq	87	4	.3	.3	CD
cord-018572-e2qq4ngq	87	5	)	)	-RRB-
cord-018572-e2qq4ngq	87	6	.	.	.
cord-018572-e2qq4ngq	88	1	A	a	DT
cord-018572-e2qq4ngq	88	2	recent	recent	JJ
cord-018572-e2qq4ngq	88	3	phylogenetic	phylogenetic	JJ
cord-018572-e2qq4ngq	88	4	study	study	NN
cord-018572-e2qq4ngq	88	5	has	have	VBZ
cord-018572-e2qq4ngq	88	6	indicated	indicate	VBN
cord-018572-e2qq4ngq	88	7	that	that	IN
cord-018572-e2qq4ngq	88	8	six	six	CD
cord-018572-e2qq4ngq	88	9	Arf	Arf	NNP
cord-018572-e2qq4ngq	88	10	GAP	GAP	NNP
cord-018572-e2qq4ngq	88	11	families	family	NNS
cord-018572-e2qq4ngq	88	12	(	(	-LRB-
cord-018572-e2qq4ngq	88	13	ArfGAP1	arfgap1	NN
cord-018572-e2qq4ngq	88	14	,	,	,
cord-018572-e2qq4ngq	88	15	ArfGAP2/3	arfgap2/3	UH
cord-018572-e2qq4ngq	88	16	,	,	,
cord-018572-e2qq4ngq	88	17	SMAP	SMAP	NNP
cord-018572-e2qq4ngq	88	18	,	,	,
cord-018572-e2qq4ngq	88	19	ACAP	ACAP	NNP
cord-018572-e2qq4ngq	88	20	,	,	,
cord-018572-e2qq4ngq	88	21	AGFG	AGFG	NNP
cord-018572-e2qq4ngq	88	22	,	,	,
cord-018572-e2qq4ngq	88	23	and	and	CC
cord-018572-e2qq4ngq	88	24	the	the	DT
cord-018572-e2qq4ngq	88	25	newly	newly	RB
cord-018572-e2qq4ngq	88	26	identified	identify	VBN
cord-018572-e2qq4ngq	88	27	ArfGAPC2	arfgapc2	NN
cord-018572-e2qq4ngq	88	28	family	family	NN
cord-018572-e2qq4ngq	88	29	)	)	-RRB-
cord-018572-e2qq4ngq	88	30	are	be	VBP
cord-018572-e2qq4ngq	88	31	ancient	ancient	JJ
cord-018572-e2qq4ngq	88	32	,	,	,
cord-018572-e2qq4ngq	88	33	probably	probably	RB
cord-018572-e2qq4ngq	88	34	existing	exist	VBG
cord-018572-e2qq4ngq	88	35	in	in	IN
cord-018572-e2qq4ngq	88	36	the	the	DT
cord-018572-e2qq4ngq	88	37	LECA	LECA	NNP
cord-018572-e2qq4ngq	88	38	prior	prior	RB
cord-018572-e2qq4ngq	88	39	to	to	IN
cord-018572-e2qq4ngq	88	40	separation	separation	NN
cord-018572-e2qq4ngq	88	41	of	of	IN
cord-018572-e2qq4ngq	88	42	the	the	DT
cord-018572-e2qq4ngq	88	43	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	88	44	supergroups	supergroup	NNS
cord-018572-e2qq4ngq	88	45	.	.	.
cord-018572-e2qq4ngq	89	1	On	on	IN
cord-018572-e2qq4ngq	89	2	the	the	DT
cord-018572-e2qq4ngq	89	3	other	other	JJ
cord-018572-e2qq4ngq	89	4	hand	hand	NN
cord-018572-e2qq4ngq	89	5	,	,	,
cord-018572-e2qq4ngq	89	6	ASAP	ASAP	NNP
cord-018572-e2qq4ngq	89	7	,	,	,
cord-018572-e2qq4ngq	89	8	ARAP	ARAP	NNP
cord-018572-e2qq4ngq	89	9	,	,	,
cord-018572-e2qq4ngq	89	10	and	and	CC
cord-018572-e2qq4ngq	89	11	GIT	GIT	NNP
cord-018572-e2qq4ngq	89	12	families	family	NNS
cord-018572-e2qq4ngq	89	13	arose	arise	VBD
cord-018572-e2qq4ngq	89	14	more	more	RBR
cord-018572-e2qq4ngq	89	15	recently	recently	RB
cord-018572-e2qq4ngq	89	16	in	in	IN
cord-018572-e2qq4ngq	89	17	evolution	evolution	NN
cord-018572-e2qq4ngq	89	18	,	,	,
cord-018572-e2qq4ngq	89	19	being	be	VBG
cord-018572-e2qq4ngq	89	20	found	find	VBN
cord-018572-e2qq4ngq	89	21	only	only	RB
cord-018572-e2qq4ngq	89	22	in	in	IN
cord-018572-e2qq4ngq	89	23	animals	animal	NNS
cord-018572-e2qq4ngq	89	24	.	.	.
cord-018572-e2qq4ngq	90	1	Through	through	IN
cord-018572-e2qq4ngq	90	2	the	the	DT
cord-018572-e2qq4ngq	90	3	course	course	NN
cord-018572-e2qq4ngq	90	4	of	of	IN
cord-018572-e2qq4ngq	90	5	evolution	evolution	NN
cord-018572-e2qq4ngq	90	6	,	,	,
cord-018572-e2qq4ngq	90	7	the	the	DT
cord-018572-e2qq4ngq	90	8	Arf	Arf	NNP
cord-018572-e2qq4ngq	90	9	GAPs	gaps	NN
cord-018572-e2qq4ngq	90	10	have	have	VBP
cord-018572-e2qq4ngq	90	11	undergone	undergo	VBN
cord-018572-e2qq4ngq	90	12	extensive	extensive	JJ
cord-018572-e2qq4ngq	90	13	domain	domain	NN
cord-018572-e2qq4ngq	90	14	shuffling	shuffle	VBG
cord-018572-e2qq4ngq	90	15	,	,	,
cord-018572-e2qq4ngq	90	16	losing	lose	VBG
cord-018572-e2qq4ngq	90	17	and	and	CC
cord-018572-e2qq4ngq	90	18	gaining	gain	VBG
cord-018572-e2qq4ngq	90	19	different	different	JJ
cord-018572-e2qq4ngq	90	20	domains	domain	NNS
cord-018572-e2qq4ngq	90	21	in	in	IN
cord-018572-e2qq4ngq	90	22	a	a	DT
cord-018572-e2qq4ngq	90	23	complex	complex	JJ
cord-018572-e2qq4ngq	90	24	pattern	pattern	NN
cord-018572-e2qq4ngq	90	25	to	to	TO
cord-018572-e2qq4ngq	90	26	give	give	VB
cord-018572-e2qq4ngq	90	27	rise	rise	NN
cord-018572-e2qq4ngq	90	28	to	to	IN
cord-018572-e2qq4ngq	90	29	the	the	DT
cord-018572-e2qq4ngq	90	30	proteins	protein	NNS
cord-018572-e2qq4ngq	90	31	existing	exist	VBG
cord-018572-e2qq4ngq	90	32	today	today	NN
cord-018572-e2qq4ngq	91	1	(	(	-LRB-
cord-018572-e2qq4ngq	91	2	Schlacht	Schlacht	NNP
cord-018572-e2qq4ngq	91	3	et	et	FW
cord-018572-e2qq4ngq	91	4	al	al	NNP
cord-018572-e2qq4ngq	91	5	.	.	NNP
cord-018572-e2qq4ngq	91	6	2013	2013	CD
cord-018572-e2qq4ngq	91	7	)	)	-RRB-
cord-018572-e2qq4ngq	91	8	.	.	.
cord-018572-e2qq4ngq	92	1	The	the	DT
cord-018572-e2qq4ngq	92	2	PH	PH	NNP
cord-018572-e2qq4ngq	92	3	,	,	,
cord-018572-e2qq4ngq	92	4	BAR	bar	NN
cord-018572-e2qq4ngq	92	5	,	,	,
cord-018572-e2qq4ngq	92	6	RhoGAP	rhogap	NN
cord-018572-e2qq4ngq	92	7	,	,	,
cord-018572-e2qq4ngq	92	8	ankyrin	ankyrin	NNP
cord-018572-e2qq4ngq	92	9	repeat	repeat	NN
cord-018572-e2qq4ngq	92	10	,	,	,
cord-018572-e2qq4ngq	92	11	and	and	CC
cord-018572-e2qq4ngq	92	12	C2	c2	NN
cord-018572-e2qq4ngq	92	13	domains	domain	NNS
cord-018572-e2qq4ngq	92	14	of	of	IN
cord-018572-e2qq4ngq	92	15	Arf	Arf	NNP
cord-018572-e2qq4ngq	92	16	GAP	GAP	NNP
cord-018572-e2qq4ngq	92	17	proteins	protein	NNS
cord-018572-e2qq4ngq	92	18	are	be	VBP
cord-018572-e2qq4ngq	92	19	conserved	conserve	VBN
cord-018572-e2qq4ngq	92	20	across	across	IN
cord-018572-e2qq4ngq	92	21	eukaryotes	eukaryote	NNS
cord-018572-e2qq4ngq	92	22	,	,	,
cord-018572-e2qq4ngq	92	23	and	and	CC
cord-018572-e2qq4ngq	92	24	therefore	therefore	RB
cord-018572-e2qq4ngq	92	25	were	be	VBD
cord-018572-e2qq4ngq	92	26	probably	probably	RB
cord-018572-e2qq4ngq	92	27	present	present	JJ
cord-018572-e2qq4ngq	92	28	in	in	IN
cord-018572-e2qq4ngq	92	29	the	the	DT
cord-018572-e2qq4ngq	92	30	primordial	primordial	JJ
cord-018572-e2qq4ngq	92	31	Arf	Arf	NNP
cord-018572-e2qq4ngq	92	32	GAPs	gaps	NN
cord-018572-e2qq4ngq	92	33	,	,	,
cord-018572-e2qq4ngq	92	34	whereas	whereas	IN
cord-018572-e2qq4ngq	92	35	other	other	JJ
cord-018572-e2qq4ngq	92	36	domains	domain	NNS
cord-018572-e2qq4ngq	92	37	such	such	JJ
cord-018572-e2qq4ngq	92	38	as	as	IN
cord-018572-e2qq4ngq	92	39	GOLD	gold	NN
cord-018572-e2qq4ngq	92	40	,	,	,
cord-018572-e2qq4ngq	92	41	CALM	calm	JJ
cord-018572-e2qq4ngq	92	42	,	,	,
cord-018572-e2qq4ngq	92	43	and	and	CC
cord-018572-e2qq4ngq	92	44	SH3	SH3	NNP
cord-018572-e2qq4ngq	92	45	domains	domain	NNS
cord-018572-e2qq4ngq	92	46	are	be	VBP
cord-018572-e2qq4ngq	92	47	restricted	restrict	VBN
cord-018572-e2qq4ngq	92	48	to	to	IN
cord-018572-e2qq4ngq	92	49	specific	specific	JJ
cord-018572-e2qq4ngq	92	50	lineages	lineage	NNS
cord-018572-e2qq4ngq	92	51	(	(	-LRB-
cord-018572-e2qq4ngq	92	52	Schlacht	Schlacht	NNP
cord-018572-e2qq4ngq	92	53	et	et	FW
cord-018572-e2qq4ngq	92	54	al	al	NNP
cord-018572-e2qq4ngq	92	55	.	.	NNP
cord-018572-e2qq4ngq	92	56	2013	2013	CD
cord-018572-e2qq4ngq	92	57	)	)	-RRB-
cord-018572-e2qq4ngq	92	58	.	.	.
cord-018572-e2qq4ngq	93	1	The	the	DT
cord-018572-e2qq4ngq	93	2	first	first	JJ
cord-018572-e2qq4ngq	93	3	Arf	Arf	NNP
cord-018572-e2qq4ngq	93	4	GAP	GAP	NNP
cord-018572-e2qq4ngq	93	5	identified	identify	VBN
cord-018572-e2qq4ngq	93	6	was	be	VBD
cord-018572-e2qq4ngq	93	7	ArfGAP1	ArfGAP1	NNS
cord-018572-e2qq4ngq	93	8	(	(	-LRB-
cord-018572-e2qq4ngq	93	9	Cukierman	Cukierman	NNP
cord-018572-e2qq4ngq	93	10	et	et	NNP
cord-018572-e2qq4ngq	93	11	al	al	NNP
cord-018572-e2qq4ngq	93	12	.	.	NNP
cord-018572-e2qq4ngq	93	13	1995	1995	CD
cord-018572-e2qq4ngq	93	14	)	)	-RRB-
cord-018572-e2qq4ngq	93	15	,	,	,
cord-018572-e2qq4ngq	93	16	which	which	WDT
cord-018572-e2qq4ngq	93	17	has	have	VBZ
cord-018572-e2qq4ngq	93	18	two	two	CD
cord-018572-e2qq4ngq	93	19	ALPS	alp	NNS
cord-018572-e2qq4ngq	93	20	motifs	motif	NNS
cord-018572-e2qq4ngq	93	21	in	in	IN
cord-018572-e2qq4ngq	93	22	its	-PRON-	PRP$
cord-018572-e2qq4ngq	93	23	C	c	NN
cord-018572-e2qq4ngq	93	24	-	-	HYPH
cord-018572-e2qq4ngq	93	25	terminal	terminal	NN
cord-018572-e2qq4ngq	93	26	region	region	NN
cord-018572-e2qq4ngq	93	27	that	that	WDT
cord-018572-e2qq4ngq	93	28	mediate	mediate	VBP
cord-018572-e2qq4ngq	93	29	specific	specific	JJ
cord-018572-e2qq4ngq	93	30	binding	binding	NN
cord-018572-e2qq4ngq	93	31	to	to	IN
cord-018572-e2qq4ngq	93	32	the	the	DT
cord-018572-e2qq4ngq	93	33	highly	highly	RB
cord-018572-e2qq4ngq	93	34	 	 	_SP
cord-018572-e2qq4ngq	93	35	curved	curved	JJ
cord-018572-e2qq4ngq	93	36	membranes	membrane	NNS
cord-018572-e2qq4ngq	93	37	of	of	IN
cord-018572-e2qq4ngq	93	38	COPI	COPI	NNP
cord-018572-e2qq4ngq	93	39	vesicles	vesicle	NNS
cord-018572-e2qq4ngq	94	1	(	(	-LRB-
cord-018572-e2qq4ngq	94	2	Bigay	Bigay	NNP
cord-018572-e2qq4ngq	94	3	et	et	NNP
cord-018572-e2qq4ngq	94	4	al	al	NNP
cord-018572-e2qq4ngq	94	5	.	.	.
cord-018572-e2qq4ngq	95	1	2003	2003	CD
cord-018572-e2qq4ngq	96	1	(	(	-LRB-
cord-018572-e2qq4ngq	96	2	Bigay	Bigay	NNP
cord-018572-e2qq4ngq	96	3	et	et	NNP
cord-018572-e2qq4ngq	96	4	al	al	NNP
cord-018572-e2qq4ngq	96	5	.	.	.
cord-018572-e2qq4ngq	97	1	,	,	,
cord-018572-e2qq4ngq	97	2	2005	2005	CD
cord-018572-e2qq4ngq	98	1	Mesmin	Mesmin	NNP
cord-018572-e2qq4ngq	98	2	et	et	NNP
cord-018572-e2qq4ngq	98	3	al	al	NNP
cord-018572-e2qq4ngq	98	4	.	.	NNP
cord-018572-e2qq4ngq	98	5	2007	2007	CD
cord-018572-e2qq4ngq	98	6	)	)	-RRB-
cord-018572-e2qq4ngq	98	7	.	.	.
cord-018572-e2qq4ngq	99	1	In	in	IN
cord-018572-e2qq4ngq	99	2	an	an	DT
cord-018572-e2qq4ngq	99	3	elegant	elegant	JJ
cord-018572-e2qq4ngq	99	4	self	self	NN
cord-018572-e2qq4ngq	99	5	-	-	HYPH
cord-018572-e2qq4ngq	99	6	organizing	organize	VBG
cord-018572-e2qq4ngq	99	7	mechanism	mechanism	NN
cord-018572-e2qq4ngq	99	8	,	,	,
cord-018572-e2qq4ngq	99	9	COPI	COPI	NNP
cord-018572-e2qq4ngq	99	10	vesicles	vesicle	NNS
cord-018572-e2qq4ngq	99	11	are	be	VBP
cord-018572-e2qq4ngq	99	12	generated	generate	VBN
cord-018572-e2qq4ngq	99	13	through	through	IN
cord-018572-e2qq4ngq	99	14	activation	activation	NN
cord-018572-e2qq4ngq	99	15	of	of	IN
cord-018572-e2qq4ngq	99	16	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	99	17	at	at	IN
cord-018572-e2qq4ngq	99	18	the	the	DT
cord-018572-e2qq4ngq	99	19	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	99	20	,	,	,
cord-018572-e2qq4ngq	99	21	which	which	WDT
cord-018572-e2qq4ngq	99	22	recruits	recruit	VBZ
cord-018572-e2qq4ngq	99	23	COPI	COPI	NNP
cord-018572-e2qq4ngq	99	24	to	to	TO
cord-018572-e2qq4ngq	99	25	deform	deform	VB
cord-018572-e2qq4ngq	99	26	the	the	DT
cord-018572-e2qq4ngq	99	27	membrane	membrane	NN
cord-018572-e2qq4ngq	99	28	into	into	IN
cord-018572-e2qq4ngq	99	29	a	a	DT
cord-018572-e2qq4ngq	99	30	highly	highly	RB
cord-018572-e2qq4ngq	99	31	curved	curved	JJ
cord-018572-e2qq4ngq	99	32	vesicle	vesicle	NN
cord-018572-e2qq4ngq	99	33	,	,	,
cord-018572-e2qq4ngq	99	34	which	which	WDT
cord-018572-e2qq4ngq	99	35	then	then	RB
cord-018572-e2qq4ngq	99	36	recruits	recruit	VBZ
cord-018572-e2qq4ngq	99	37	ArfGAP1	arfgap1	NN
cord-018572-e2qq4ngq	99	38	through	through	IN
cord-018572-e2qq4ngq	99	39	its	-PRON-	PRP$
cord-018572-e2qq4ngq	99	40	ALPS	ALPS	NNP
cord-018572-e2qq4ngq	99	41	motif	motif	NN
cord-018572-e2qq4ngq	99	42	to	to	IN
cord-018572-e2qq4ngq	99	43	hydrolyse	hydrolyse	VB
cord-018572-e2qq4ngq	99	44	the	the	DT
cord-018572-e2qq4ngq	99	45	GTP	GTP	NNP
cord-018572-e2qq4ngq	99	46	on	on	IN
cord-018572-e2qq4ngq	99	47	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	99	48	,	,	,
cord-018572-e2qq4ngq	99	49	releasing	release	VBG
cord-018572-e2qq4ngq	99	50	the	the	DT
cord-018572-e2qq4ngq	99	51	coat	coat	NN
cord-018572-e2qq4ngq	99	52	and	and	CC
cord-018572-e2qq4ngq	99	53	allowing	allow	VBG
cord-018572-e2qq4ngq	99	54	fusion	fusion	NN
cord-018572-e2qq4ngq	99	55	of	of	IN
cord-018572-e2qq4ngq	99	56	the	the	DT
cord-018572-e2qq4ngq	99	57	vesicle	vesicle	NN
cord-018572-e2qq4ngq	99	58	with	with	IN
cord-018572-e2qq4ngq	99	59	its	-PRON-	PRP$
cord-018572-e2qq4ngq	99	60	target	target	NN
cord-018572-e2qq4ngq	99	61	membrane	membrane	NN
cord-018572-e2qq4ngq	99	62	(	(	-LRB-
cord-018572-e2qq4ngq	99	63	Bigay	Bigay	NNP
cord-018572-e2qq4ngq	99	64	et	et	NNP
cord-018572-e2qq4ngq	99	65	al	al	NNP
cord-018572-e2qq4ngq	99	66	.	.	NNP
cord-018572-e2qq4ngq	99	67	2003	2003	CD
cord-018572-e2qq4ngq	99	68	)	)	-RRB-
cord-018572-e2qq4ngq	99	69	.	.	.
cord-018572-e2qq4ngq	100	1	ArfGAP2	ArfGAP2	NNP
cord-018572-e2qq4ngq	100	2	and	and	CC
cord-018572-e2qq4ngq	100	3	3	3	CD
cord-018572-e2qq4ngq	100	4	also	also	RB
cord-018572-e2qq4ngq	100	5	bind	bind	VB
cord-018572-e2qq4ngq	100	6	to	to	IN
cord-018572-e2qq4ngq	100	7	COPI	COPI	NNP
cord-018572-e2qq4ngq	100	8	vesicles	vesicle	NNS
cord-018572-e2qq4ngq	100	9	,	,	,
cord-018572-e2qq4ngq	100	10	but	but	CC
cord-018572-e2qq4ngq	100	11	do	do	VBP
cord-018572-e2qq4ngq	100	12	so	so	RB
cord-018572-e2qq4ngq	100	13	through	through	IN
cord-018572-e2qq4ngq	100	14	direct	direct	JJ
cord-018572-e2qq4ngq	100	15	interaction	interaction	NN
cord-018572-e2qq4ngq	100	16	with	with	IN
cord-018572-e2qq4ngq	100	17	the	the	DT
cord-018572-e2qq4ngq	100	18	COPI	COPI	NNP
cord-018572-e2qq4ngq	100	19	coat	coat	NN
cord-018572-e2qq4ngq	100	20	,	,	,
cord-018572-e2qq4ngq	100	21	and	and	CC
cord-018572-e2qq4ngq	100	22	hence	hence	RB
cord-018572-e2qq4ngq	100	23	can	can	MD
cord-018572-e2qq4ngq	100	24	also	also	RB
cord-018572-e2qq4ngq	100	25	bind	bind	VB
cord-018572-e2qq4ngq	100	26	to	to	IN
cord-018572-e2qq4ngq	100	27	COPI	COPI	NNP
cord-018572-e2qq4ngq	100	28	-	-	HYPH
cord-018572-e2qq4ngq	100	29	coated	coat	VBN
cord-018572-e2qq4ngq	100	30	regions	region	NNS
cord-018572-e2qq4ngq	100	31	that	that	WDT
cord-018572-e2qq4ngq	100	32	are	be	VBP
cord-018572-e2qq4ngq	100	33	not	not	RB
cord-018572-e2qq4ngq	100	34	highly	highly	RB
cord-018572-e2qq4ngq	100	35	curved	curved	JJ
cord-018572-e2qq4ngq	100	36	(	(	-LRB-
cord-018572-e2qq4ngq	100	37	Kliouchnikov	Kliouchnikov	NNP
cord-018572-e2qq4ngq	100	38	et	et	FW
cord-018572-e2qq4ngq	100	39	al	al	NNP
cord-018572-e2qq4ngq	100	40	.	.	.
cord-018572-e2qq4ngq	100	41	2009	2009	CD
cord-018572-e2qq4ngq	100	42	;	;	.
cord-018572-e2qq4ngq	101	1	Weimer	Weimer	NNP
cord-018572-e2qq4ngq	101	2	et	et	NNP
cord-018572-e2qq4ngq	101	3	al	al	NNP
cord-018572-e2qq4ngq	101	4	.	.	NNP
cord-018572-e2qq4ngq	101	5	2008	2008	CD
cord-018572-e2qq4ngq	101	6	)	)	-RRB-
cord-018572-e2qq4ngq	101	7	.	.	.
cord-018572-e2qq4ngq	102	1	ArfGAP1	ArfGAP1	NNP
cord-018572-e2qq4ngq	102	2	,	,	,
cord-018572-e2qq4ngq	102	3	2	2	CD
cord-018572-e2qq4ngq	102	4	,	,	,
cord-018572-e2qq4ngq	102	5	and	and	CC
cord-018572-e2qq4ngq	102	6	3	3	CD
cord-018572-e2qq4ngq	102	7	and	and	CC
cord-018572-e2qq4ngq	102	8	their	-PRON-	PRP$
cord-018572-e2qq4ngq	102	9	yeast	yeast	NN
cord-018572-e2qq4ngq	102	10	orthologues	orthologue	NNS
cord-018572-e2qq4ngq	102	11	Gcs1p	gcs1p	NN
cord-018572-e2qq4ngq	102	12	and	and	CC
cord-018572-e2qq4ngq	102	13	Glo3p	Glo3p	NNP
cord-018572-e2qq4ngq	102	14	function	function	VB
cord-018572-e2qq4ngq	102	15	at	at	IN
cord-018572-e2qq4ngq	102	16	the	the	DT
cord-018572-e2qq4ngq	102	17	early	early	JJ
cord-018572-e2qq4ngq	102	18	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	102	19	(	(	-LRB-
cord-018572-e2qq4ngq	102	20	Spang	Spang	NNP
cord-018572-e2qq4ngq	102	21	et	et	FW
cord-018572-e2qq4ngq	102	22	al	al	NNP
cord-018572-e2qq4ngq	102	23	.	.	NNP
cord-018572-e2qq4ngq	102	24	2010	2010	CD
cord-018572-e2qq4ngq	102	25	)	)	-RRB-
cord-018572-e2qq4ngq	102	26	,	,	,
cord-018572-e2qq4ngq	102	27	whereas	whereas	IN
cord-018572-e2qq4ngq	102	28	most	most	JJS
cord-018572-e2qq4ngq	102	29	of	of	IN
cord-018572-e2qq4ngq	102	30	the	the	DT
cord-018572-e2qq4ngq	102	31	other	other	JJ
cord-018572-e2qq4ngq	102	32	Arf	Arf	NNP
cord-018572-e2qq4ngq	102	33	GAPs	gaps	NN
cord-018572-e2qq4ngq	102	34	function	function	NN
cord-018572-e2qq4ngq	102	35	at	at	IN
cord-018572-e2qq4ngq	102	36	the	the	DT
cord-018572-e2qq4ngq	102	37	cell	cell	NN
cord-018572-e2qq4ngq	102	38	periphery	periphery	NN
cord-018572-e2qq4ngq	102	39	in	in	IN
cord-018572-e2qq4ngq	102	40	TGN	TGN	NNP
cord-018572-e2qq4ngq	102	41	-	-	HYPH
cord-018572-e2qq4ngq	102	42	endosomal	endosomal	NN
cord-018572-e2qq4ngq	102	43	-	-	HYPH
cord-018572-e2qq4ngq	102	44	plasma	plasma	NN
cord-018572-e2qq4ngq	102	45	membrane	membrane	NN
cord-018572-e2qq4ngq	102	46	trafficking	trafficking	NN
cord-018572-e2qq4ngq	102	47	and	and	CC
cord-018572-e2qq4ngq	102	48	actin	actin	NN
cord-018572-e2qq4ngq	102	49	cytoskeleton	cytoskeleton	NN
cord-018572-e2qq4ngq	102	50	remodelling	remodelling	NN
cord-018572-e2qq4ngq	102	51	(	(	-LRB-
cord-018572-e2qq4ngq	102	52	Inoue	Inoue	NNP
cord-018572-e2qq4ngq	102	53	and	and	CC
cord-018572-e2qq4ngq	102	54	Randazzo	Randazzo	NNP
cord-018572-e2qq4ngq	102	55	2007	2007	CD
cord-018572-e2qq4ngq	102	56	;	;	:
cord-018572-e2qq4ngq	102	57	Sabe	Sabe	NNP
cord-018572-e2qq4ngq	102	58	et	et	NNP
cord-018572-e2qq4ngq	102	59	al	al	NNP
cord-018572-e2qq4ngq	102	60	.	.	.
cord-018572-e2qq4ngq	102	61	2006	2006	CD
cord-018572-e2qq4ngq	102	62	)	)	-RRB-
cord-018572-e2qq4ngq	102	63	.	.	.
cord-018572-e2qq4ngq	103	1	The	the	DT
cord-018572-e2qq4ngq	103	2	following	follow	VBG
cord-018572-e2qq4ngq	103	3	chapter	chapter	NN
cord-018572-e2qq4ngq	103	4	in	in	IN
cord-018572-e2qq4ngq	103	5	this	this	DT
cord-018572-e2qq4ngq	103	6	volume	volume	NN
cord-018572-e2qq4ngq	103	7	will	will	MD
cord-018572-e2qq4ngq	103	8	describe	describe	VB
cord-018572-e2qq4ngq	103	9	the	the	DT
cord-018572-e2qq4ngq	103	10	latter	latter	JJ
cord-018572-e2qq4ngq	103	11	class	class	NN
cord-018572-e2qq4ngq	103	12	of	of	IN
cord-018572-e2qq4ngq	103	13	Arf	Arf	NNP
cord-018572-e2qq4ngq	103	14	GAPs	gaps	NN
cord-018572-e2qq4ngq	103	15	in	in	IN
cord-018572-e2qq4ngq	103	16	depth	depth	NN
cord-018572-e2qq4ngq	103	17	.	.	.
cord-018572-e2qq4ngq	104	1	A	a	DT
cord-018572-e2qq4ngq	104	2	major	major	JJ
cord-018572-e2qq4ngq	104	3	distinguishing	distinguishing	JJ
cord-018572-e2qq4ngq	104	4	feature	feature	NN
cord-018572-e2qq4ngq	104	5	of	of	IN
cord-018572-e2qq4ngq	104	6	the	the	DT
cord-018572-e2qq4ngq	104	7	Arf	Arf	NNP
cord-018572-e2qq4ngq	104	8	proteins	protein	NNS
cord-018572-e2qq4ngq	104	9	is	be	VBZ
cord-018572-e2qq4ngq	104	10	the	the	DT
cord-018572-e2qq4ngq	104	11	presence	presence	NN
cord-018572-e2qq4ngq	104	12	of	of	IN
cord-018572-e2qq4ngq	104	13	a	a	DT
cord-018572-e2qq4ngq	104	14	myristoylated	myristoylate	VBN
cord-018572-e2qq4ngq	104	15	amino	amino	NN
cord-018572-e2qq4ngq	104	16	-	-	HYPH
cord-018572-e2qq4ngq	104	17	terminal	terminal	NN
cord-018572-e2qq4ngq	104	18	amphipathic	amphipathic	NNP
cord-018572-e2qq4ngq	104	19	helix	helix	NNP
cord-018572-e2qq4ngq	104	20	that	that	WDT
cord-018572-e2qq4ngq	104	21	is	be	VBZ
cord-018572-e2qq4ngq	104	22	necessary	necessary	JJ
cord-018572-e2qq4ngq	104	23	for	for	IN
cord-018572-e2qq4ngq	104	24	membrane	membrane	NN
cord-018572-e2qq4ngq	104	25	binding	binding	NN
cord-018572-e2qq4ngq	104	26	(	(	-LRB-
cord-018572-e2qq4ngq	104	27	Fig	Fig	NNP
cord-018572-e2qq4ngq	104	28	.	.	.
cord-018572-e2qq4ngq	104	29	8.1a	8.1a	CD
cord-018572-e2qq4ngq	104	30	,	,	,
cord-018572-e2qq4ngq	104	31	b	b	NN
cord-018572-e2qq4ngq	104	32	,	,	,
cord-018572-e2qq4ngq	104	33	c	c	NNP
cord-018572-e2qq4ngq	104	34	)	)	-RRB-
cord-018572-e2qq4ngq	104	35	.	.	.
cord-018572-e2qq4ngq	105	1	Myristoylation	myristoylation	NN
cord-018572-e2qq4ngq	105	2	is	be	VBZ
cord-018572-e2qq4ngq	105	3	a	a	DT
cord-018572-e2qq4ngq	105	4	cotranslational	cotranslational	JJ
cord-018572-e2qq4ngq	105	5	modification	modification	NN
cord-018572-e2qq4ngq	105	6	required	require	VBN
cord-018572-e2qq4ngq	105	7	for	for	IN
cord-018572-e2qq4ngq	105	8	the	the	DT
cord-018572-e2qq4ngq	105	9	essential	essential	JJ
cord-018572-e2qq4ngq	105	10	functions	function	NNS
cord-018572-e2qq4ngq	105	11	of	of	IN
cord-018572-e2qq4ngq	105	12	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	105	13	in	in	IN
cord-018572-e2qq4ngq	105	14	vivo	vivo	NNP
cord-018572-e2qq4ngq	105	15	(	(	-LRB-
cord-018572-e2qq4ngq	105	16	Kahn	Kahn	NNP
cord-018572-e2qq4ngq	105	17	et	et	NNP
cord-018572-e2qq4ngq	105	18	al	al	NNP
cord-018572-e2qq4ngq	105	19	.	.	NNP
cord-018572-e2qq4ngq	105	20	1995	1995	CD
cord-018572-e2qq4ngq	105	21	)	)	-RRB-
cord-018572-e2qq4ngq	105	22	.	.	.
cord-018572-e2qq4ngq	106	1	In	in	IN
cord-018572-e2qq4ngq	106	2	cells	cell	NNS
cord-018572-e2qq4ngq	106	3	,	,	,
cord-018572-e2qq4ngq	106	4	myristoylation	myristoylation	NN
cord-018572-e2qq4ngq	106	5	is	be	VBZ
cord-018572-e2qq4ngq	106	6	required	require	VBN
cord-018572-e2qq4ngq	106	7	for	for	IN
cord-018572-e2qq4ngq	106	8	correct	correct	JJ
cord-018572-e2qq4ngq	106	9	localization	localization	NN
cord-018572-e2qq4ngq	106	10	of	of	IN
cord-018572-e2qq4ngq	106	11	Arf	Arf	NNP
cord-018572-e2qq4ngq	106	12	proteins	protein	NNS
cord-018572-e2qq4ngq	106	13	,	,	,
cord-018572-e2qq4ngq	106	14	including	include	VBG
cord-018572-e2qq4ngq	106	15	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	106	16	localization	localization	NN
cord-018572-e2qq4ngq	106	17	of	of	IN
cord-018572-e2qq4ngq	106	18	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	106	19	and	and	CC
cord-018572-e2qq4ngq	106	20	PM	PM	NNP
cord-018572-e2qq4ngq	106	21	localization	localization	NN
cord-018572-e2qq4ngq	106	22	of	of	IN
cord-018572-e2qq4ngq	106	23	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	106	24	(	(	-LRB-
cord-018572-e2qq4ngq	106	25	Donaldson	Donaldson	NNP
cord-018572-e2qq4ngq	106	26	and	and	CC
cord-018572-e2qq4ngq	106	27	Jackson	Jackson	NNP
cord-018572-e2qq4ngq	106	28	2011	2011	CD
cord-018572-e2qq4ngq	106	29	)	)	-RRB-
cord-018572-e2qq4ngq	106	30	.	.	.
cord-018572-e2qq4ngq	107	1	In	in	IN
cord-018572-e2qq4ngq	107	2	vitro	vitro	FW
cord-018572-e2qq4ngq	107	3	,	,	,
cord-018572-e2qq4ngq	107	4	the	the	DT
cord-018572-e2qq4ngq	107	5	myristoyl	myristoyl	NNP
cord-018572-e2qq4ngq	107	6	group	group	NN
cord-018572-e2qq4ngq	107	7	of	of	IN
cord-018572-e2qq4ngq	107	8	the	the	DT
cord-018572-e2qq4ngq	107	9	GDP	GDP	NNP
cord-018572-e2qq4ngq	107	10	-	-	HYPH
cord-018572-e2qq4ngq	107	11	bound	bind	VBN
cord-018572-e2qq4ngq	107	12	form	form	NN
cord-018572-e2qq4ngq	107	13	of	of	IN
cord-018572-e2qq4ngq	107	14	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	107	15	is	be	VBZ
cord-018572-e2qq4ngq	107	16	available	available	JJ
cord-018572-e2qq4ngq	107	17	for	for	IN
cord-018572-e2qq4ngq	107	18	membrane	membrane	NN
cord-018572-e2qq4ngq	107	19	insertion	insertion	NN
cord-018572-e2qq4ngq	107	20	,	,	,
cord-018572-e2qq4ngq	107	21	permitting	permit	VBG
cord-018572-e2qq4ngq	107	22	a	a	DT
cord-018572-e2qq4ngq	107	23	weak	weak	JJ
cord-018572-e2qq4ngq	107	24	association	association	NN
cord-018572-e2qq4ngq	107	25	of	of	IN
cord-018572-e2qq4ngq	107	26	the	the	DT
cord-018572-e2qq4ngq	107	27	inactive	inactive	JJ
cord-018572-e2qq4ngq	107	28	form	form	NN
cord-018572-e2qq4ngq	107	29	of	of	IN
cord-018572-e2qq4ngq	107	30	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	107	31	with	with	IN
cord-018572-e2qq4ngq	107	32	membranes	membrane	NNS
cord-018572-e2qq4ngq	107	33	(	(	-LRB-
cord-018572-e2qq4ngq	107	34	Franco	Franco	NNP
cord-018572-e2qq4ngq	107	35	et	et	NNP
cord-018572-e2qq4ngq	107	36	al	al	NNP
cord-018572-e2qq4ngq	107	37	.	.	NNP
cord-018572-e2qq4ngq	107	38	1995	1995	CD
cord-018572-e2qq4ngq	107	39	)	)	-RRB-
cord-018572-e2qq4ngq	107	40	.	.	.
cord-018572-e2qq4ngq	108	1	Upon	upon	IN
cord-018572-e2qq4ngq	108	2	GTP	gtp	NN
cord-018572-e2qq4ngq	108	3	binding	binding	NN
cord-018572-e2qq4ngq	108	4	,	,	,
cord-018572-e2qq4ngq	108	5	the	the	DT
cord-018572-e2qq4ngq	108	6	N	n	CD
cord-018572-e2qq4ngq	108	7	-	-	HYPH
cord-018572-e2qq4ngq	108	8	terminal	terminal	NN
cord-018572-e2qq4ngq	108	9	amphipathic	amphipathic	NNP
cord-018572-e2qq4ngq	108	10	helix	helix	NN
cord-018572-e2qq4ngq	108	11	of	of	IN
cord-018572-e2qq4ngq	108	12	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	108	13	is	be	VBZ
cord-018572-e2qq4ngq	108	14	released	release	VBN
cord-018572-e2qq4ngq	108	15	and	and	CC
cord-018572-e2qq4ngq	108	16	inserts	insert	NNS
cord-018572-e2qq4ngq	108	17	into	into	IN
cord-018572-e2qq4ngq	108	18	the	the	DT
cord-018572-e2qq4ngq	108	19	membrane	membrane	NN
cord-018572-e2qq4ngq	108	20	,	,	,
cord-018572-e2qq4ngq	108	21	resulting	result	VBG
cord-018572-e2qq4ngq	108	22	in	in	IN
cord-018572-e2qq4ngq	108	23	tight	tight	JJ
cord-018572-e2qq4ngq	108	24	membrane	membrane	NN
cord-018572-e2qq4ngq	108	25	association	association	NN
cord-018572-e2qq4ngq	108	26	(	(	-LRB-
cord-018572-e2qq4ngq	108	27	Antonny	Antonny	NNP
cord-018572-e2qq4ngq	108	28	et	et	NNP
cord-018572-e2qq4ngq	108	29	al	al	NNP
cord-018572-e2qq4ngq	108	30	.	.	.
cord-018572-e2qq4ngq	108	31	1997	1997	CD
cord-018572-e2qq4ngq	108	32	)	)	-RRB-
cord-018572-e2qq4ngq	109	1	(	(	-LRB-
cord-018572-e2qq4ngq	109	2	Fig	Fig	NNP
cord-018572-e2qq4ngq	109	3	.	.	.
cord-018572-e2qq4ngq	109	4	8.1c	8.1c	CD
cord-018572-e2qq4ngq	109	5	)	)	-RRB-
cord-018572-e2qq4ngq	109	6	.	.	.
cord-018572-e2qq4ngq	110	1	Structural	structural	JJ
cord-018572-e2qq4ngq	110	2	studies	study	NNS
cord-018572-e2qq4ngq	110	3	revealed	reveal	VBD
cord-018572-e2qq4ngq	110	4	the	the	DT
cord-018572-e2qq4ngq	110	5	details	detail	NNS
cord-018572-e2qq4ngq	110	6	of	of	IN
cord-018572-e2qq4ngq	110	7	this	this	DT
cord-018572-e2qq4ngq	110	8	change	change	NN
cord-018572-e2qq4ngq	110	9	in	in	IN
cord-018572-e2qq4ngq	110	10	conformation	conformation	NN
cord-018572-e2qq4ngq	110	11	,	,	,
cord-018572-e2qq4ngq	110	12	showing	show	VBG
cord-018572-e2qq4ngq	110	13	that	that	IN
cord-018572-e2qq4ngq	110	14	the	the	DT
cord-018572-e2qq4ngq	110	15	interswitch	interswitch	NN
cord-018572-e2qq4ngq	110	16	region	region	NN
cord-018572-e2qq4ngq	110	17	changes	change	VBZ
cord-018572-e2qq4ngq	110	18	position	position	VBP
cord-018572-e2qq4ngq	110	19	to	to	TO
cord-018572-e2qq4ngq	110	20	occlude	occlude	VB
cord-018572-e2qq4ngq	110	21	the	the	DT
cord-018572-e2qq4ngq	110	22	hydrophobic	hydrophobic	JJ
cord-018572-e2qq4ngq	110	23	pocket	pocket	NN
cord-018572-e2qq4ngq	110	24	that	that	WDT
cord-018572-e2qq4ngq	110	25	harbours	harbour	VBZ
cord-018572-e2qq4ngq	110	26	the	the	DT
cord-018572-e2qq4ngq	110	27	amphipathic	amphipathic	JJ
cord-018572-e2qq4ngq	110	28	N	N	NNP
cord-018572-e2qq4ngq	110	29	-	-	HYPH
cord-018572-e2qq4ngq	110	30	terminal	terminal	JJ
cord-018572-e2qq4ngq	110	31	helix	helix	NN
cord-018572-e2qq4ngq	110	32	in	in	IN
cord-018572-e2qq4ngq	110	33	the	the	DT
cord-018572-e2qq4ngq	110	34	GDP	gdp	NN
cord-018572-e2qq4ngq	110	35	-	-	HYPH
cord-018572-e2qq4ngq	110	36	bound	bind	VBN
cord-018572-e2qq4ngq	110	37	form	form	NN
cord-018572-e2qq4ngq	110	38	of	of	IN
cord-018572-e2qq4ngq	110	39	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	110	40	(	(	-LRB-
cord-018572-e2qq4ngq	110	41	Goldberg	Goldberg	NNP
cord-018572-e2qq4ngq	110	42	1998	1998	CD
cord-018572-e2qq4ngq	110	43	)	)	-RRB-
cord-018572-e2qq4ngq	110	44	.	.	.
cord-018572-e2qq4ngq	111	1	NMR	NMR	NNP
cord-018572-e2qq4ngq	111	2	studies	study	NNS
cord-018572-e2qq4ngq	111	3	of	of	IN
cord-018572-e2qq4ngq	111	4	N	N	NNP
cord-018572-e2qq4ngq	111	5	-	-	HYPH
cord-018572-e2qq4ngq	111	6	myristoylated	myristoylate	VBN
cord-018572-e2qq4ngq	111	7	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	111	8	further	further	RB
cord-018572-e2qq4ngq	111	9	confirmed	confirm	VBD
cord-018572-e2qq4ngq	111	10	this	this	DT
cord-018572-e2qq4ngq	111	11	mechanism	mechanism	NN
cord-018572-e2qq4ngq	111	12	(	(	-LRB-
cord-018572-e2qq4ngq	111	13	Liu	Liu	NNP
cord-018572-e2qq4ngq	111	14	et	et	NNP
cord-018572-e2qq4ngq	111	15	al	al	NNP
cord-018572-e2qq4ngq	111	16	.	.	NNP
cord-018572-e2qq4ngq	111	17	2010	2010	CD
cord-018572-e2qq4ngq	111	18	)	)	-RRB-
cord-018572-e2qq4ngq	111	19	.	.	.
cord-018572-e2qq4ngq	112	1	Thus	thus	RB
cord-018572-e2qq4ngq	112	2	,	,	,
cord-018572-e2qq4ngq	112	3	in	in	IN
cord-018572-e2qq4ngq	112	4	addition	addition	NN
cord-018572-e2qq4ngq	112	5	to	to	IN
cord-018572-e2qq4ngq	112	6	changes	change	NNS
cord-018572-e2qq4ngq	112	7	in	in	IN
cord-018572-e2qq4ngq	112	8	the	the	DT
cord-018572-e2qq4ngq	112	9	effector	effector	NN
cord-018572-e2qq4ngq	112	10	binding	bind	VBG
cord-018572-e2qq4ngq	112	11	regions	region	NNS
cord-018572-e2qq4ngq	112	12	upon	upon	IN
cord-018572-e2qq4ngq	112	13	exchange	exchange	NN
cord-018572-e2qq4ngq	112	14	of	of	IN
cord-018572-e2qq4ngq	112	15	GDP	GDP	NNP
cord-018572-e2qq4ngq	112	16	for	for	IN
cord-018572-e2qq4ngq	112	17	GTP	GTP	NNP
cord-018572-e2qq4ngq	112	18	,	,	,
cord-018572-e2qq4ngq	112	19	Arf	Arf	NNP
cord-018572-e2qq4ngq	112	20	proteins	protein	NNS
cord-018572-e2qq4ngq	112	21	undergo	undergo	VBP
cord-018572-e2qq4ngq	112	22	a	a	DT
cord-018572-e2qq4ngq	112	23	second	second	JJ
cord-018572-e2qq4ngq	112	24	change	change	NN
cord-018572-e2qq4ngq	112	25	in	in	IN
cord-018572-e2qq4ngq	112	26	conformation	conformation	NN
cord-018572-e2qq4ngq	112	27	that	that	WDT
cord-018572-e2qq4ngq	112	28	brings	bring	VBZ
cord-018572-e2qq4ngq	112	29	them	-PRON-	PRP
cord-018572-e2qq4ngq	112	30	into	into	IN
cord-018572-e2qq4ngq	112	31	very	very	RB
cord-018572-e2qq4ngq	112	32	close	close	JJ
cord-018572-e2qq4ngq	112	33	contact	contact	NN
cord-018572-e2qq4ngq	112	34	with	with	IN
cord-018572-e2qq4ngq	112	35	the	the	DT
cord-018572-e2qq4ngq	112	36	membrane	membrane	NN
cord-018572-e2qq4ngq	112	37	(	(	-LRB-
cord-018572-e2qq4ngq	112	38	Fig	fig	NN
cord-018572-e2qq4ngq	112	39	.	.	.
cord-018572-e2qq4ngq	113	1	8	8	CD
cord-018572-e2qq4ngq	113	2	.1c	.1c	CD
cord-018572-e2qq4ngq	113	3	)	)	-RRB-
cord-018572-e2qq4ngq	114	1	(	(	-LRB-
cord-018572-e2qq4ngq	114	2	Antonny	Antonny	NNP
cord-018572-e2qq4ngq	114	3	et	et	NNP
cord-018572-e2qq4ngq	114	4	al	al	NNP
cord-018572-e2qq4ngq	114	5	.	.	.
cord-018572-e2qq4ngq	115	1	1997	1997	CD
cord-018572-e2qq4ngq	115	2	;	;	:
cord-018572-e2qq4ngq	115	3	Chavrier	Chavrier	NNP
cord-018572-e2qq4ngq	115	4	and	and	CC
cord-018572-e2qq4ngq	115	5	Menetrey	Menetrey	NNP
cord-018572-e2qq4ngq	115	6	2010	2010	CD
cord-018572-e2qq4ngq	115	7	)	)	-RRB-
cord-018572-e2qq4ngq	115	8	.	.	.
cord-018572-e2qq4ngq	116	1	This	this	DT
cord-018572-e2qq4ngq	116	2	property	property	NN
cord-018572-e2qq4ngq	116	3	distinguishes	distinguish	VBZ
cord-018572-e2qq4ngq	116	4	them	-PRON-	PRP
cord-018572-e2qq4ngq	116	5	from	from	IN
cord-018572-e2qq4ngq	116	6	other	other	JJ
cord-018572-e2qq4ngq	116	7	small	small	JJ
cord-018572-e2qq4ngq	116	8	G	g	NN
cord-018572-e2qq4ngq	116	9	proteins	protein	NNS
cord-018572-e2qq4ngq	116	10	of	of	IN
cord-018572-e2qq4ngq	116	11	the	the	DT
cord-018572-e2qq4ngq	116	12	Ras	Ras	NNP
cord-018572-e2qq4ngq	116	13	superfamily	superfamily	NN
cord-018572-e2qq4ngq	116	14	,	,	,
cord-018572-e2qq4ngq	116	15	including	include	VBG
cord-018572-e2qq4ngq	116	16	the	the	DT
cord-018572-e2qq4ngq	116	17	Ras	Ras	NNP
cord-018572-e2qq4ngq	116	18	,	,	,
cord-018572-e2qq4ngq	116	19	Rho	Rho	NNP
cord-018572-e2qq4ngq	116	20	,	,	,
cord-018572-e2qq4ngq	116	21	and	and	CC
cord-018572-e2qq4ngq	116	22	Rab	Rab	NNP
cord-018572-e2qq4ngq	116	23	Families	Families	NNP
cord-018572-e2qq4ngq	116	24	,	,	,
cord-018572-e2qq4ngq	116	25	which	which	WDT
cord-018572-e2qq4ngq	116	26	have	have	VBP
cord-018572-e2qq4ngq	116	27	a	a	DT
cord-018572-e2qq4ngq	116	28	long	long	JJ
cord-018572-e2qq4ngq	116	29	C	c	NN
cord-018572-e2qq4ngq	116	30	-	-	HYPH
cord-018572-e2qq4ngq	116	31	terminal	terminal	NN
cord-018572-e2qq4ngq	116	32	linker	linker	NN
cord-018572-e2qq4ngq	116	33	to	to	TO
cord-018572-e2qq4ngq	116	34	which	which	WDT
cord-018572-e2qq4ngq	116	35	their	-PRON-	PRP$
cord-018572-e2qq4ngq	116	36	lipid	lipid	NN
cord-018572-e2qq4ngq	116	37	membrane	membrane	NN
cord-018572-e2qq4ngq	116	38	anchor	anchor	NN
cord-018572-e2qq4ngq	116	39	is	be	VBZ
cord-018572-e2qq4ngq	116	40	attached	attach	VBN
cord-018572-e2qq4ngq	116	41	(	(	-LRB-
cord-018572-e2qq4ngq	116	42	Gillingham	Gillingham	NNP
cord-018572-e2qq4ngq	116	43	and	and	CC
cord-018572-e2qq4ngq	116	44	Munro	Munro	NNP
cord-018572-e2qq4ngq	116	45	2007b	2007b	CD
cord-018572-e2qq4ngq	116	46	)	)	-RRB-
cord-018572-e2qq4ngq	116	47	.	.	.
cord-018572-e2qq4ngq	117	1	Arf	Arf	NNP
cord-018572-e2qq4ngq	117	2	effectors	effector	NNS
cord-018572-e2qq4ngq	117	3	are	be	VBP
cord-018572-e2qq4ngq	117	4	thus	thus	RB
cord-018572-e2qq4ngq	117	5	constrained	constrain	VBN
cord-018572-e2qq4ngq	117	6	to	to	IN
cord-018572-e2qq4ngq	117	7	a	a	DT
cord-018572-e2qq4ngq	117	8	position	position	NN
cord-018572-e2qq4ngq	117	9	close	close	RB
cord-018572-e2qq4ngq	117	10	to	to	IN
cord-018572-e2qq4ngq	117	11	the	the	DT
cord-018572-e2qq4ngq	117	12	membrane	membrane	NN
cord-018572-e2qq4ngq	117	13	,	,	,
cord-018572-e2qq4ngq	117	14	in	in	IN
cord-018572-e2qq4ngq	117	15	contrast	contrast	NN
cord-018572-e2qq4ngq	117	16	to	to	IN
cord-018572-e2qq4ngq	117	17	those	those	DT
cord-018572-e2qq4ngq	117	18	of	of	IN
cord-018572-e2qq4ngq	117	19	Rab	Rab	NNP
cord-018572-e2qq4ngq	117	20	and	and	CC
cord-018572-e2qq4ngq	117	21	Rho	Rho	NNP
cord-018572-e2qq4ngq	117	22	,	,	,
cord-018572-e2qq4ngq	117	23	which	which	WDT
cord-018572-e2qq4ngq	117	24	can	can	MD
cord-018572-e2qq4ngq	117	25	be	be	VB
cord-018572-e2qq4ngq	117	26	located	locate	VBN
cord-018572-e2qq4ngq	117	27	at	at	IN
cord-018572-e2qq4ngq	117	28	a	a	DT
cord-018572-e2qq4ngq	117	29	distance	distance	NN
cord-018572-e2qq4ngq	117	30	from	from	IN
cord-018572-e2qq4ngq	117	31	the	the	DT
cord-018572-e2qq4ngq	117	32	membrane	membrane	NN
cord-018572-e2qq4ngq	117	33	surface	surface	NN
cord-018572-e2qq4ngq	117	34	(	(	-LRB-
cord-018572-e2qq4ngq	117	35	Gillingham	Gillingham	NNP
cord-018572-e2qq4ngq	117	36	and	and	CC
cord-018572-e2qq4ngq	117	37	Munro	Munro	NNP
cord-018572-e2qq4ngq	117	38	2007b	2007b	CD
cord-018572-e2qq4ngq	117	39	;	;	:
cord-018572-e2qq4ngq	117	40	Khan	Khan	NNP
cord-018572-e2qq4ngq	117	41	and	and	CC
cord-018572-e2qq4ngq	117	42	Menetrey	Menetrey	NNP
cord-018572-e2qq4ngq	117	43	2013	2013	CD
cord-018572-e2qq4ngq	117	44	)	)	-RRB-
cord-018572-e2qq4ngq	117	45	.	.	.
cord-018572-e2qq4ngq	118	1	Another	another	DT
cord-018572-e2qq4ngq	118	2	distinction	distinction	NN
cord-018572-e2qq4ngq	118	3	between	between	IN
cord-018572-e2qq4ngq	118	4	Arf	Arf	NNP
cord-018572-e2qq4ngq	118	5	proteins	protein	NNS
cord-018572-e2qq4ngq	118	6	and	and	CC
cord-018572-e2qq4ngq	118	7	those	those	DT
cord-018572-e2qq4ngq	118	8	of	of	IN
cord-018572-e2qq4ngq	118	9	the	the	DT
cord-018572-e2qq4ngq	118	10	Rab	Rab	NNP
cord-018572-e2qq4ngq	118	11	and	and	CC
cord-018572-e2qq4ngq	118	12	Rho	Rho	NNP
cord-018572-e2qq4ngq	118	13	families	family	NNS
cord-018572-e2qq4ngq	118	14	is	be	VBZ
cord-018572-e2qq4ngq	118	15	that	that	IN
cord-018572-e2qq4ngq	118	16	no	no	DT
cord-018572-e2qq4ngq	118	17	guanosine	guanosine	NN
cord-018572-e2qq4ngq	118	18	diphosphate	diphosphate	NN
cord-018572-e2qq4ngq	118	19	dissociation	dissociation	NN
cord-018572-e2qq4ngq	118	20	inhibitors	inhibitor	NNS
cord-018572-e2qq4ngq	118	21	(	(	-LRB-
cord-018572-e2qq4ngq	118	22	GDI	GDI	NNP
cord-018572-e2qq4ngq	118	23	)	)	-RRB-
cord-018572-e2qq4ngq	118	24	have	have	VBP
cord-018572-e2qq4ngq	118	25	been	be	VBN
cord-018572-e2qq4ngq	118	26	identified	identify	VBN
cord-018572-e2qq4ngq	118	27	.	.	.
cord-018572-e2qq4ngq	119	1	All	all	DT
cord-018572-e2qq4ngq	119	2	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	119	3	are	be	VBP
cord-018572-e2qq4ngq	119	4	tightly	tightly	RB
cord-018572-e2qq4ngq	119	5	membrane	membrane	NN
cord-018572-e2qq4ngq	119	6	bound	bind	VBN
cord-018572-e2qq4ngq	119	7	in	in	IN
cord-018572-e2qq4ngq	119	8	their	-PRON-	PRP$
cord-018572-e2qq4ngq	119	9	active	active	JJ
cord-018572-e2qq4ngq	119	10	GTP	gtp	NN
cord-018572-e2qq4ngq	119	11	-	-	HYPH
cord-018572-e2qq4ngq	119	12	bound	bind	VBN
cord-018572-e2qq4ngq	119	13	conformation	conformation	NN
cord-018572-e2qq4ngq	119	14	because	because	IN
cord-018572-e2qq4ngq	119	15	of	of	IN
cord-018572-e2qq4ngq	119	16	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	119	17	regulation	regulation	NN
cord-018572-e2qq4ngq	119	18	of	of	IN
cord-018572-e2qq4ngq	119	19	the	the	DT
cord-018572-e2qq4ngq	119	20	position	position	NN
cord-018572-e2qq4ngq	119	21	of	of	IN
cord-018572-e2qq4ngq	119	22	the	the	DT
cord-018572-e2qq4ngq	119	23	N	n	CD
cord-018572-e2qq4ngq	119	24	-	-	HYPH
cord-018572-e2qq4ngq	119	25	terminal	terminal	NN
cord-018572-e2qq4ngq	119	26	amphipathic	amphipathic	NNP
cord-018572-e2qq4ngq	119	27	helix	helix	NNP
cord-018572-e2qq4ngq	119	28	,	,	,
cord-018572-e2qq4ngq	119	29	and	and	CC
cord-018572-e2qq4ngq	119	30	simply	simply	RB
cord-018572-e2qq4ngq	119	31	hydrolysing	hydrolyse	VBG
cord-018572-e2qq4ngq	119	32	the	the	DT
cord-018572-e2qq4ngq	119	33	GTP	GTP	NNP
cord-018572-e2qq4ngq	119	34	on	on	IN
cord-018572-e2qq4ngq	119	35	Arf	Arf	NNP
cord-018572-e2qq4ngq	119	36	proteins	protein	NNS
cord-018572-e2qq4ngq	119	37	is	be	VBZ
cord-018572-e2qq4ngq	119	38	sufficient	sufficient	JJ
cord-018572-e2qq4ngq	119	39	to	to	TO
cord-018572-e2qq4ngq	119	40	render	render	VB
cord-018572-e2qq4ngq	119	41	them	-PRON-	PRP
cord-018572-e2qq4ngq	119	42	soluble	soluble	JJ
cord-018572-e2qq4ngq	119	43	in	in	IN
cord-018572-e2qq4ngq	119	44	vitro	vitro	FW
cord-018572-e2qq4ngq	119	45	.	.	.
cord-018572-e2qq4ngq	120	1	Indeed	indeed	RB
cord-018572-e2qq4ngq	120	2	,	,	,
cord-018572-e2qq4ngq	120	3	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	120	4	and	and	CC
cord-018572-e2qq4ngq	120	5	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	120	6	appear	appear	VBP
cord-018572-e2qq4ngq	120	7	to	to	TO
cord-018572-e2qq4ngq	120	8	be	be	VB
cord-018572-e2qq4ngq	120	9	released	release	VBN
cord-018572-e2qq4ngq	120	10	from	from	IN
cord-018572-e2qq4ngq	120	11	membranes	membrane	NNS
cord-018572-e2qq4ngq	120	12	into	into	IN
cord-018572-e2qq4ngq	120	13	the	the	DT
cord-018572-e2qq4ngq	120	14	cytosol	cytosol	NN
cord-018572-e2qq4ngq	120	15	upon	upon	IN
cord-018572-e2qq4ngq	120	16	GTP	gtp	NN
cord-018572-e2qq4ngq	120	17	hydrolysis	hydrolysis	NN
cord-018572-e2qq4ngq	120	18	in	in	IN
cord-018572-e2qq4ngq	120	19	cells	cell	NNS
cord-018572-e2qq4ngq	120	20	.	.	.
cord-018572-e2qq4ngq	121	1	However	however	RB
cord-018572-e2qq4ngq	121	2	,	,	,
cord-018572-e2qq4ngq	121	3	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	121	4	remains	remain	VBZ
cord-018572-e2qq4ngq	121	5	bound	bind	VBN
cord-018572-e2qq4ngq	121	6	to	to	IN
cord-018572-e2qq4ngq	121	7	membranes	membrane	NNS
cord-018572-e2qq4ngq	121	8	in	in	IN
cord-018572-e2qq4ngq	121	9	cells	cell	NNS
cord-018572-e2qq4ngq	121	10	in	in	IN
cord-018572-e2qq4ngq	121	11	its	-PRON-	PRP$
cord-018572-e2qq4ngq	121	12	GDP	gdp	NN
cord-018572-e2qq4ngq	121	13	-	-	HYPH
cord-018572-e2qq4ngq	121	14	bound	bind	VBN
cord-018572-e2qq4ngq	121	15	conformation	conformation	NN
cord-018572-e2qq4ngq	121	16	.	.	.
cord-018572-e2qq4ngq	122	1	There	there	EX
cord-018572-e2qq4ngq	122	2	is	be	VBZ
cord-018572-e2qq4ngq	122	3	also	also	RB
cord-018572-e2qq4ngq	122	4	evidence	evidence	NN
cord-018572-e2qq4ngq	122	5	that	that	IN
cord-018572-e2qq4ngq	122	6	Arf4-GDP	arf4-gdp	NN
cord-018572-e2qq4ngq	122	7	and	and	CC
cord-018572-e2qq4ngq	122	8	Arf5-GDP	arf5-gdp	NN
cord-018572-e2qq4ngq	122	9	remain	remain	VBP
cord-018572-e2qq4ngq	122	10	membrane	membrane	NN
cord-018572-e2qq4ngq	122	11	bound	bind	VBN
cord-018572-e2qq4ngq	122	12	in	in	IN
cord-018572-e2qq4ngq	122	13	cells	cell	NNS
cord-018572-e2qq4ngq	122	14	,	,	,
cord-018572-e2qq4ngq	122	15	in	in	IN
cord-018572-e2qq4ngq	122	16	the	the	DT
cord-018572-e2qq4ngq	122	17	latter	latter	JJ
cord-018572-e2qq4ngq	122	18	case	case	NN
cord-018572-e2qq4ngq	122	19	,	,	,
cord-018572-e2qq4ngq	122	20	to	to	IN
cord-018572-e2qq4ngq	122	21	the	the	DT
cord-018572-e2qq4ngq	122	22	ER	ER	NNP
cord-018572-e2qq4ngq	122	23	-	-	HYPH
cord-018572-e2qq4ngq	122	24	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	122	25	intermediate	intermediate	JJ
cord-018572-e2qq4ngq	122	26	compartment	compartment	NN
cord-018572-e2qq4ngq	122	27	(	(	-LRB-
cord-018572-e2qq4ngq	122	28	ERGIC	ERGIC	NNP
cord-018572-e2qq4ngq	122	29	)	)	-RRB-
cord-018572-e2qq4ngq	122	30	Duijsings	Duijsings	NNP
cord-018572-e2qq4ngq	122	31	et	et	NNP
cord-018572-e2qq4ngq	122	32	al	al	NNP
cord-018572-e2qq4ngq	122	33	.	.	.
cord-018572-e2qq4ngq	122	34	2009	2009	CD
cord-018572-e2qq4ngq	122	35	)	)	-RRB-
cord-018572-e2qq4ngq	122	36	.	.	.
cord-018572-e2qq4ngq	123	1	This	this	DT
cord-018572-e2qq4ngq	123	2	membrane	membrane	NN
cord-018572-e2qq4ngq	123	3	association	association	NN
cord-018572-e2qq4ngq	123	4	is	be	VBZ
cord-018572-e2qq4ngq	123	5	likely	likely	JJ
cord-018572-e2qq4ngq	123	6	due	due	IN
cord-018572-e2qq4ngq	123	7	to	to	IN
cord-018572-e2qq4ngq	123	8	interaction	interaction	NN
cord-018572-e2qq4ngq	123	9	of	of	IN
cord-018572-e2qq4ngq	123	10	the	the	DT
cord-018572-e2qq4ngq	123	11	GDP	GDP	NNP
cord-018572-e2qq4ngq	123	12	-	-	HYPH
cord-018572-e2qq4ngq	123	13	bound	bind	VBN
cord-018572-e2qq4ngq	123	14	forms	form	NNS
cord-018572-e2qq4ngq	123	15	with	with	IN
cord-018572-e2qq4ngq	123	16	membrane	membrane	NN
cord-018572-e2qq4ngq	123	17	-	-	HYPH
cord-018572-e2qq4ngq	123	18	associated	associate	VBN
cord-018572-e2qq4ngq	123	19	proteins	protein	NNS
cord-018572-e2qq4ngq	123	20	.	.	.
cord-018572-e2qq4ngq	124	1	For	for	IN
cord-018572-e2qq4ngq	124	2	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	124	3	,	,	,
cord-018572-e2qq4ngq	124	4	members	member	NNS
cord-018572-e2qq4ngq	124	5	of	of	IN
cord-018572-e2qq4ngq	124	6	the	the	DT
cord-018572-e2qq4ngq	124	7	Kalirin	Kalirin	NNP
cord-018572-e2qq4ngq	124	8	family	family	NN
cord-018572-e2qq4ngq	124	9	of	of	IN
cord-018572-e2qq4ngq	124	10	Rho	Rho	NNP
cord-018572-e2qq4ngq	124	11	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	124	12	have	have	VBP
cord-018572-e2qq4ngq	124	13	been	be	VBN
cord-018572-e2qq4ngq	124	14	shown	show	VBN
cord-018572-e2qq4ngq	124	15	to	to	TO
cord-018572-e2qq4ngq	124	16	bind	bind	VB
cord-018572-e2qq4ngq	124	17	specifically	specifically	RB
cord-018572-e2qq4ngq	124	18	to	to	IN
cord-018572-e2qq4ngq	124	19	the	the	DT
cord-018572-e2qq4ngq	124	20	GDP	GDP	NNP
cord-018572-e2qq4ngq	124	21	-	-	HYPH
cord-018572-e2qq4ngq	124	22	bound	bind	VBN
cord-018572-e2qq4ngq	124	23	form	form	NN
cord-018572-e2qq4ngq	124	24	through	through	IN
cord-018572-e2qq4ngq	124	25	their	-PRON-	PRP$
cord-018572-e2qq4ngq	124	26	spectrin	spectrin	NNS
cord-018572-e2qq4ngq	124	27	-	-	HYPH
cord-018572-e2qq4ngq	124	28	like	like	JJ
cord-018572-e2qq4ngq	124	29	repeat	repeat	NN
cord-018572-e2qq4ngq	124	30	domain	domain	NN
cord-018572-e2qq4ngq	124	31	(	(	-LRB-
cord-018572-e2qq4ngq	124	32	Koo	Koo	NNP
cord-018572-e2qq4ngq	124	33	et	et	FW
cord-018572-e2qq4ngq	124	34	al	al	NNP
cord-018572-e2qq4ngq	124	35	.	.	NNP
cord-018572-e2qq4ngq	124	36	2007	2007	CD
cord-018572-e2qq4ngq	124	37	)	)	-RRB-
cord-018572-e2qq4ngq	124	38	.	.	.
cord-018572-e2qq4ngq	125	1	Arf6-GDP	Arf6-GDP	NNP
cord-018572-e2qq4ngq	125	2	recruits	recruit	VBZ
cord-018572-e2qq4ngq	125	3	Kalirin	Kalirin	NNP
cord-018572-e2qq4ngq	125	4	to	to	IN
cord-018572-e2qq4ngq	125	5	the	the	DT
cord-018572-e2qq4ngq	125	6	membrane	membrane	NN
cord-018572-e2qq4ngq	125	7	where	where	WRB
cord-018572-e2qq4ngq	125	8	it	-PRON-	PRP
cord-018572-e2qq4ngq	125	9	subsequently	subsequently	RB
cord-018572-e2qq4ngq	125	10	activates	activate	VBZ
cord-018572-e2qq4ngq	125	11	Rac	Rac	NNP
cord-018572-e2qq4ngq	125	12	and	and	CC
cord-018572-e2qq4ngq	125	13	RhoG	RhoG	NNP
cord-018572-e2qq4ngq	125	14	to	to	TO
cord-018572-e2qq4ngq	125	15	regulate	regulate	VB
cord-018572-e2qq4ngq	125	16	actin	actin	NN
cord-018572-e2qq4ngq	125	17	dynamics	dynamic	NNS
cord-018572-e2qq4ngq	125	18	(	(	-LRB-
cord-018572-e2qq4ngq	125	19	Koo	Koo	NNP
cord-018572-e2qq4ngq	125	20	et	et	FW
cord-018572-e2qq4ngq	125	21	al	al	NNP
cord-018572-e2qq4ngq	125	22	.	.	NNP
cord-018572-e2qq4ngq	125	23	2007	2007	CD
cord-018572-e2qq4ngq	125	24	)	)	-RRB-
cord-018572-e2qq4ngq	125	25	.	.	.
cord-018572-e2qq4ngq	126	1	Arf6-GDP	Arf6-GDP	NNP
cord-018572-e2qq4ngq	126	2	binds	bind	VBZ
cord-018572-e2qq4ngq	126	3	several	several	JJ
cord-018572-e2qq4ngq	126	4	TBC	TBC	NNP
cord-018572-e2qq4ngq	126	5	(	(	-LRB-
cord-018572-e2qq4ngq	126	6	Tre-2	Tre-2	NNP
cord-018572-e2qq4ngq	126	7	/	/	SYM
cord-018572-e2qq4ngq	126	8	Bub	Bub	NNP
cord-018572-e2qq4ngq	126	9	/	/	SYM
cord-018572-e2qq4ngq	126	10	Cdc16	Cdc16	NNP
cord-018572-e2qq4ngq	126	11	)	)	-RRB-
cord-018572-e2qq4ngq	126	12	domaincontaining	domaincontaining	NN
cord-018572-e2qq4ngq	126	13	proteins	protein	NNS
cord-018572-e2qq4ngq	126	14	,	,	,
cord-018572-e2qq4ngq	126	15	which	which	WDT
cord-018572-e2qq4ngq	126	16	have	have	VBP
cord-018572-e2qq4ngq	126	17	Rab	Rab	NNP
cord-018572-e2qq4ngq	126	18	GAP	GAP	NNP
cord-018572-e2qq4ngq	126	19	activity	activity	NN
cord-018572-e2qq4ngq	127	1	(	(	-LRB-
cord-018572-e2qq4ngq	127	2	Haas	Haas	NNP
cord-018572-e2qq4ngq	127	3	et	et	NNP
cord-018572-e2qq4ngq	127	4	al	al	NNP
cord-018572-e2qq4ngq	127	5	.	.	NNP
cord-018572-e2qq4ngq	127	6	2007	2007	CD
cord-018572-e2qq4ngq	127	7	)	)	-RRB-
cord-018572-e2qq4ngq	127	8	,	,	,
cord-018572-e2qq4ngq	127	9	including	include	VBG
cord-018572-e2qq4ngq	127	10	TBC1D24	TBC1D24	NNP
cord-018572-e2qq4ngq	127	11	,	,	,
cord-018572-e2qq4ngq	127	12	a	a	DT
cord-018572-e2qq4ngq	127	13	protein	protein	NN
cord-018572-e2qq4ngq	127	14	mutated	mutate	VBN
cord-018572-e2qq4ngq	127	15	in	in	IN
cord-018572-e2qq4ngq	127	16	familial	familial	JJ
cord-018572-e2qq4ngq	127	17	infantile	infantile	JJ
cord-018572-e2qq4ngq	127	18	myoclonic	myoclonic	JJ
cord-018572-e2qq4ngq	127	19	epilepsy	epilepsy	NN
cord-018572-e2qq4ngq	128	1	(	(	-LRB-
cord-018572-e2qq4ngq	128	2	Falace	Falace	NNP
cord-018572-e2qq4ngq	128	3	et	et	NNP
cord-018572-e2qq4ngq	128	4	al	al	NNP
cord-018572-e2qq4ngq	128	5	.	.	NNP
cord-018572-e2qq4ngq	128	6	2010	2010	CD
cord-018572-e2qq4ngq	128	7	)	)	-RRB-
cord-018572-e2qq4ngq	128	8	,	,	,
cord-018572-e2qq4ngq	128	9	and	and	CC
cord-018572-e2qq4ngq	128	10	the	the	DT
cord-018572-e2qq4ngq	128	11	TRE17	TRE17	NNP
cord-018572-e2qq4ngq	128	12	oncogene	oncogene	NN
cord-018572-e2qq4ngq	128	13	(	(	-LRB-
cord-018572-e2qq4ngq	128	14	Martinu	Martinu	NNP
cord-018572-e2qq4ngq	128	15	et	et	NNP
cord-018572-e2qq4ngq	128	16	al	al	NNP
cord-018572-e2qq4ngq	128	17	.	.	.
cord-018572-e2qq4ngq	128	18	2004	2004	CD
cord-018572-e2qq4ngq	128	19	)	)	-RRB-
cord-018572-e2qq4ngq	128	20	.	.	.
cord-018572-e2qq4ngq	129	1	Hence	hence	RB
cord-018572-e2qq4ngq	129	2	interactions	interaction	NNS
cord-018572-e2qq4ngq	129	3	with	with	IN
cord-018572-e2qq4ngq	129	4	the	the	DT
cord-018572-e2qq4ngq	129	5	GDP	gdp	NN
cord-018572-e2qq4ngq	129	6	-	-	HYPH
cord-018572-e2qq4ngq	129	7	bound	bind	VBN
cord-018572-e2qq4ngq	129	8	form	form	NN
cord-018572-e2qq4ngq	129	9	of	of	IN
cord-018572-e2qq4ngq	129	10	a	a	DT
cord-018572-e2qq4ngq	129	11	G	g	NN
cord-018572-e2qq4ngq	129	12	protein	protein	NN
cord-018572-e2qq4ngq	129	13	could	could	MD
cord-018572-e2qq4ngq	129	14	provide	provide	VB
cord-018572-e2qq4ngq	129	15	a	a	DT
cord-018572-e2qq4ngq	129	16	mechanism	mechanism	NN
cord-018572-e2qq4ngq	129	17	for	for	IN
cord-018572-e2qq4ngq	129	18	a	a	DT
cord-018572-e2qq4ngq	129	19	single	single	JJ
cord-018572-e2qq4ngq	129	20	Arf	Arf	NNP
cord-018572-e2qq4ngq	129	21	protein	protein	NN
cord-018572-e2qq4ngq	129	22	to	to	TO
cord-018572-e2qq4ngq	129	23	trigger	trigger	VB
cord-018572-e2qq4ngq	129	24	alternative	alternative	JJ
cord-018572-e2qq4ngq	129	25	signalling	signal	VBG
cord-018572-e2qq4ngq	129	26	pathways	pathway	NNS
cord-018572-e2qq4ngq	129	27	depending	depend	VBG
cord-018572-e2qq4ngq	129	28	on	on	IN
cord-018572-e2qq4ngq	129	29	the	the	DT
cord-018572-e2qq4ngq	129	30	nucleotide	nucleotide	NN
cord-018572-e2qq4ngq	129	31	bound	bind	VBN
cord-018572-e2qq4ngq	129	32	,	,	,
cord-018572-e2qq4ngq	129	33	which	which	WDT
cord-018572-e2qq4ngq	129	34	could	could	MD
cord-018572-e2qq4ngq	129	35	have	have	VB
cord-018572-e2qq4ngq	129	36	important	important	JJ
cord-018572-e2qq4ngq	129	37	implications	implication	NNS
cord-018572-e2qq4ngq	129	38	in	in	IN
cord-018572-e2qq4ngq	129	39	human	human	JJ
cord-018572-e2qq4ngq	129	40	disease	disease	NN
cord-018572-e2qq4ngq	129	41	(	(	-LRB-
cord-018572-e2qq4ngq	129	42	Donaldson	Donaldson	NNP
cord-018572-e2qq4ngq	129	43	and	and	CC
cord-018572-e2qq4ngq	129	44	Jackson	Jackson	NNP
cord-018572-e2qq4ngq	129	45	2011	2011	CD
cord-018572-e2qq4ngq	129	46	)	)	-RRB-
cord-018572-e2qq4ngq	129	47	.	.	.
cord-018572-e2qq4ngq	130	1	Following	follow	VBG
cord-018572-e2qq4ngq	130	2	activation	activation	NN
cord-018572-e2qq4ngq	130	3	on	on	IN
cord-018572-e2qq4ngq	130	4	membranes	membrane	NNS
cord-018572-e2qq4ngq	130	5	,	,	,
cord-018572-e2qq4ngq	130	6	GTP	GTP	NNP
cord-018572-e2qq4ngq	130	7	-	-	HYPH
cord-018572-e2qq4ngq	130	8	bound	bind	VBN
cord-018572-e2qq4ngq	130	9	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	130	10	recruit	recruit	VBP
cord-018572-e2qq4ngq	130	11	coat	coat	NN
cord-018572-e2qq4ngq	130	12	proteins	protein	NNS
cord-018572-e2qq4ngq	130	13	,	,	,
cord-018572-e2qq4ngq	130	14	lipid	lipid	NN
cord-018572-e2qq4ngq	130	15	-	-	HYPH
cord-018572-e2qq4ngq	130	16	modifying	modify	VBG
cord-018572-e2qq4ngq	130	17	enzymes	enzyme	NNS
cord-018572-e2qq4ngq	130	18	,	,	,
cord-018572-e2qq4ngq	130	19	tethers	tether	NNS
cord-018572-e2qq4ngq	130	20	,	,	,
cord-018572-e2qq4ngq	130	21	and	and	CC
cord-018572-e2qq4ngq	130	22	other	other	JJ
cord-018572-e2qq4ngq	130	23	effector	effector	NN
cord-018572-e2qq4ngq	130	24	molecules	molecule	NNS
cord-018572-e2qq4ngq	130	25	that	that	WDT
cord-018572-e2qq4ngq	130	26	modulate	modulate	VBP
cord-018572-e2qq4ngq	130	27	the	the	DT
cord-018572-e2qq4ngq	130	28	properties	property	NNS
cord-018572-e2qq4ngq	130	29	of	of	IN
cord-018572-e2qq4ngq	130	30	membranes	membrane	NNS
cord-018572-e2qq4ngq	130	31	and	and	CC
cord-018572-e2qq4ngq	130	32	mediate	mediate	VB
cord-018572-e2qq4ngq	130	33	vesicle	vesicle	NN
cord-018572-e2qq4ngq	130	34	trafficking	trafficking	NN
cord-018572-e2qq4ngq	130	35	(	(	-LRB-
cord-018572-e2qq4ngq	130	36	Table	table	NN
cord-018572-e2qq4ngq	130	37	8	8	CD
cord-018572-e2qq4ngq	130	38	.1	.1	CD
cord-018572-e2qq4ngq	130	39	)	)	-RRB-
cord-018572-e2qq4ngq	130	40	.	.	.
cord-018572-e2qq4ngq	131	1	The	the	DT
cord-018572-e2qq4ngq	131	2	first	first	JJ
cord-018572-e2qq4ngq	131	3	function	function	NN
cord-018572-e2qq4ngq	131	4	of	of	IN
cord-018572-e2qq4ngq	131	5	the	the	DT
cord-018572-e2qq4ngq	131	6	Arf	Arf	NNP
cord-018572-e2qq4ngq	131	7	proteins	protein	NNS
cord-018572-e2qq4ngq	131	8	to	to	TO
cord-018572-e2qq4ngq	131	9	be	be	VB
cord-018572-e2qq4ngq	131	10	identified	identify	VBN
cord-018572-e2qq4ngq	131	11	was	be	VBD
cord-018572-e2qq4ngq	131	12	their	-PRON-	PRP$
cord-018572-e2qq4ngq	131	13	ability	ability	NN
cord-018572-e2qq4ngq	131	14	to	to	TO
cord-018572-e2qq4ngq	131	15	recruit	recruit	VB
cord-018572-e2qq4ngq	131	16	cytosolic	cytosolic	JJ
cord-018572-e2qq4ngq	131	17	coat	coat	NN
cord-018572-e2qq4ngq	131	18	proteins	protein	NNS
cord-018572-e2qq4ngq	131	19	to	to	IN
cord-018572-e2qq4ngq	131	20	membranes	membrane	NNS
cord-018572-e2qq4ngq	131	21	.	.	.
cord-018572-e2qq4ngq	132	1	In	in	IN
cord-018572-e2qq4ngq	132	2	the	the	DT
cord-018572-e2qq4ngq	132	3	early	early	JJ
cord-018572-e2qq4ngq	132	4	secretory	secretory	JJ
cord-018572-e2qq4ngq	132	5	pathway	pathway	NN
cord-018572-e2qq4ngq	132	6	,	,	,
cord-018572-e2qq4ngq	132	7	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	132	8	recruits	recruit	VBZ
cord-018572-e2qq4ngq	132	9	coatomer	coatomer	VBP
cord-018572-e2qq4ngq	132	10	complex	complex	NN
cord-018572-e2qq4ngq	133	1	I	-PRON-	PRP
cord-018572-e2qq4ngq	133	2	(	(	-LRB-
cord-018572-e2qq4ngq	133	3	COPI	COPI	NNP
cord-018572-e2qq4ngq	133	4	)	)	-RRB-
cord-018572-e2qq4ngq	133	5	,	,	,
cord-018572-e2qq4ngq	133	6	which	which	WDT
cord-018572-e2qq4ngq	133	7	sorts	sort	VBZ
cord-018572-e2qq4ngq	133	8	cargo	cargo	NN
cord-018572-e2qq4ngq	133	9	proteins	protein	NNS
cord-018572-e2qq4ngq	133	10	into	into	IN
cord-018572-e2qq4ngq	133	11	COPI	COPI	NNP
cord-018572-e2qq4ngq	133	12	-	-	HYPH
cord-018572-e2qq4ngq	133	13	coated	coat	VBN
cord-018572-e2qq4ngq	133	14	vesicles	vesicle	NNS
cord-018572-e2qq4ngq	133	15	as	as	IN
cord-018572-e2qq4ngq	133	16	it	-PRON-	PRP
cord-018572-e2qq4ngq	133	17	curves	curve	VBZ
cord-018572-e2qq4ngq	133	18	the	the	DT
cord-018572-e2qq4ngq	133	19	membrane	membrane	NN
cord-018572-e2qq4ngq	133	20	to	to	TO
cord-018572-e2qq4ngq	133	21	form	form	VB
cord-018572-e2qq4ngq	133	22	the	the	DT
cord-018572-e2qq4ngq	133	23	vesicle	vesicle	NN
cord-018572-e2qq4ngq	133	24	(	(	-LRB-
cord-018572-e2qq4ngq	133	25	Beck	Beck	NNP
cord-018572-e2qq4ngq	133	26	et	et	NNP
cord-018572-e2qq4ngq	133	27	al	al	NNP
cord-018572-e2qq4ngq	133	28	.	.	.
cord-018572-e2qq4ngq	133	29	2009	2009	CD
cord-018572-e2qq4ngq	133	30	)	)	-RRB-
cord-018572-e2qq4ngq	133	31	.	.	.
cord-018572-e2qq4ngq	134	1	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	134	2	at	at	IN
cord-018572-e2qq4ngq	134	3	the	the	DT
cord-018572-e2qq4ngq	134	4	trans	trans	NNP
cord-018572-e2qq4ngq	134	5	-	-	NNP
cord-018572-e2qq4ngq	134	6	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	134	7	network	network	NN
cord-018572-e2qq4ngq	134	8	(	(	-LRB-
cord-018572-e2qq4ngq	134	9	TGN	TGN	NNP
cord-018572-e2qq4ngq	134	10	)	)	-RRB-
cord-018572-e2qq4ngq	134	11	also	also	RB
cord-018572-e2qq4ngq	134	12	recruits	recruit	VBZ
cord-018572-e2qq4ngq	134	13	the	the	DT
cord-018572-e2qq4ngq	134	14	heterotetrameric	heterotetrameric	NNP
cord-018572-e2qq4ngq	134	15	clathrin	clathrin	NN
cord-018572-e2qq4ngq	134	16	adaptor	adaptor	NN
cord-018572-e2qq4ngq	134	17	proteins	protein	NNS
cord-018572-e2qq4ngq	134	18	(	(	-LRB-
cord-018572-e2qq4ngq	134	19	AP	AP	NNP
cord-018572-e2qq4ngq	134	20	)	)	-RRB-
cord-018572-e2qq4ngq	134	21	,	,	,
cord-018572-e2qq4ngq	134	22	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	134	23	,	,	,
cord-018572-e2qq4ngq	134	24	AP-3	AP-3	NNP
cord-018572-e2qq4ngq	134	25	,	,	,
cord-018572-e2qq4ngq	134	26	and	and	CC
cord-018572-e2qq4ngq	134	27	AP-4	AP-4	NNP
cord-018572-e2qq4ngq	134	28	and	and	CC
cord-018572-e2qq4ngq	134	29	the	the	DT
cord-018572-e2qq4ngq	134	30	three	three	CD
cord-018572-e2qq4ngq	134	31	monomeric	monomeric	JJ
cord-018572-e2qq4ngq	134	32	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	134	33	-	-	HYPH
cord-018572-e2qq4ngq	134	34	localized	localize	VBN
cord-018572-e2qq4ngq	134	35	γ	γ	NN
cord-018572-e2qq4ngq	134	36	-	-	HYPH
cord-018572-e2qq4ngq	134	37	ear	ear	NN
cord-018572-e2qq4ngq	134	38	-	-	HYPH
cord-018572-e2qq4ngq	134	39	containing	contain	VBG
cord-018572-e2qq4ngq	134	40	,	,	,
cord-018572-e2qq4ngq	134	41	ADP	ADP	NNP
cord-018572-e2qq4ngq	134	42	-	-	HYPH
cord-018572-e2qq4ngq	134	43	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	134	44	factor	factor	NN
cord-018572-e2qq4ngq	134	45	-	-	HYPH
cord-018572-e2qq4ngq	134	46	binding	bind	VBG
cord-018572-e2qq4ngq	134	47	proteins	protein	NNS
cord-018572-e2qq4ngq	134	48	(	(	-LRB-
cord-018572-e2qq4ngq	134	49	GGAs	gga	NNS
cord-018572-e2qq4ngq	134	50	1	1	CD
cord-018572-e2qq4ngq	134	51	-	-	SYM
cord-018572-e2qq4ngq	134	52	3	3	CD
cord-018572-e2qq4ngq	134	53	)	)	-RRB-
cord-018572-e2qq4ngq	135	1	(	(	-LRB-
cord-018572-e2qq4ngq	135	2	Bonifacino	Bonifacino	NNP
cord-018572-e2qq4ngq	135	3	and	and	CC
cord-018572-e2qq4ngq	135	4	Lippincott	Lippincott	NNP
cord-018572-e2qq4ngq	135	5	-	-	HYPH
cord-018572-e2qq4ngq	135	6	Schwartz	Schwartz	NNP
cord-018572-e2qq4ngq	135	7	2003	2003	CD
cord-018572-e2qq4ngq	135	8	)	)	-RRB-
cord-018572-e2qq4ngq	135	9	.	.	.
cord-018572-e2qq4ngq	136	1	These	these	DT
cord-018572-e2qq4ngq	136	2	various	various	JJ
cord-018572-e2qq4ngq	136	3	coat	coat	NN
cord-018572-e2qq4ngq	136	4	proteins	protein	NNS
cord-018572-e2qq4ngq	136	5	specifically	specifically	RB
cord-018572-e2qq4ngq	136	6	bind	bind	VBP
cord-018572-e2qq4ngq	136	7	to	to	IN
cord-018572-e2qq4ngq	136	8	cargo	cargo	NN
cord-018572-e2qq4ngq	136	9	proteins	protein	NNS
cord-018572-e2qq4ngq	136	10	and	and	CC
cord-018572-e2qq4ngq	136	11	incorporate	incorporate	VB
cord-018572-e2qq4ngq	136	12	them	-PRON-	PRP
cord-018572-e2qq4ngq	136	13	into	into	IN
cord-018572-e2qq4ngq	136	14	forming	form	VBG
cord-018572-e2qq4ngq	136	15	vesicles	vesicle	NNS
cord-018572-e2qq4ngq	136	16	for	for	IN
cord-018572-e2qq4ngq	136	17	sorting	sorting	NN
cord-018572-e2qq4ngq	136	18	and	and	CC
cord-018572-e2qq4ngq	136	19	transport	transport	NN
cord-018572-e2qq4ngq	136	20	to	to	IN
cord-018572-e2qq4ngq	136	21	their	-PRON-	PRP$
cord-018572-e2qq4ngq	136	22	correct	correct	JJ
cord-018572-e2qq4ngq	136	23	destination	destination	NN
cord-018572-e2qq4ngq	136	24	.	.	.
cord-018572-e2qq4ngq	137	1	Arf	Arf	NNP
cord-018572-e2qq4ngq	137	2	proteins	protein	NNS
cord-018572-e2qq4ngq	137	3	can	can	MD
cord-018572-e2qq4ngq	137	4	also	also	RB
cord-018572-e2qq4ngq	137	5	recruit	recruit	VB
cord-018572-e2qq4ngq	137	6	and	and	CC
cord-018572-e2qq4ngq	137	7	activate	activate	VB
cord-018572-e2qq4ngq	137	8	enzymes	enzyme	NNS
cord-018572-e2qq4ngq	137	9	that	that	WDT
cord-018572-e2qq4ngq	137	10	alter	alter	VBP
cord-018572-e2qq4ngq	137	11	membrane	membrane	NN
cord-018572-e2qq4ngq	137	12	lipid	lipid	NN
cord-018572-e2qq4ngq	137	13	composition	composition	NN
cord-018572-e2qq4ngq	137	14	.	.	.
cord-018572-e2qq4ngq	138	1	The	the	DT
cord-018572-e2qq4ngq	138	2	first	first	JJ
cord-018572-e2qq4ngq	138	3	of	of	IN
cord-018572-e2qq4ngq	138	4	these	these	DT
cord-018572-e2qq4ngq	138	5	enzymes	enzyme	NNS
cord-018572-e2qq4ngq	138	6	to	to	TO
cord-018572-e2qq4ngq	138	7	be	be	VB
cord-018572-e2qq4ngq	138	8	identified	identify	VBN
cord-018572-e2qq4ngq	138	9	was	be	VBD
cord-018572-e2qq4ngq	138	10	phospholipase	phospholipase	NN
cord-018572-e2qq4ngq	138	11	D	D	NNP
cord-018572-e2qq4ngq	138	12	(	(	-LRB-
cord-018572-e2qq4ngq	138	13	PLD	PLD	NNP
cord-018572-e2qq4ngq	138	14	)	)	-RRB-
cord-018572-e2qq4ngq	138	15	,	,	,
cord-018572-e2qq4ngq	138	16	which	which	WDT
cord-018572-e2qq4ngq	138	17	hydrolyses	hydrolyse	VBZ
cord-018572-e2qq4ngq	138	18	phosphatidylcholine	phosphatidylcholine	NN
cord-018572-e2qq4ngq	138	19	to	to	TO
cord-018572-e2qq4ngq	138	20	generate	generate	VB
cord-018572-e2qq4ngq	138	21	phosphatidic	phosphatidic	JJ
cord-018572-e2qq4ngq	138	22	acid	acid	NN
cord-018572-e2qq4ngq	138	23	(	(	-LRB-
cord-018572-e2qq4ngq	138	24	Brown	Brown	NNP
cord-018572-e2qq4ngq	138	25	et	et	NNP
cord-018572-e2qq4ngq	138	26	al	al	NNP
cord-018572-e2qq4ngq	138	27	.	.	NNP
cord-018572-e2qq4ngq	138	28	1993	1993	CD
cord-018572-e2qq4ngq	138	29	;	;	:
cord-018572-e2qq4ngq	138	30	Cockcroft	Cockcroft	NNP
cord-018572-e2qq4ngq	138	31	et	et	NNP
cord-018572-e2qq4ngq	138	32	al	al	NNP
cord-018572-e2qq4ngq	138	33	.	.	.
cord-018572-e2qq4ngq	138	34	1994	1994	CD
cord-018572-e2qq4ngq	138	35	)	)	-RRB-
cord-018572-e2qq4ngq	138	36	.	.	.
cord-018572-e2qq4ngq	139	1	PLD	PLD	NNP
cord-018572-e2qq4ngq	139	2	is	be	VBZ
cord-018572-e2qq4ngq	139	3	activated	activate	VBN
cord-018572-e2qq4ngq	139	4	by	by	IN
cord-018572-e2qq4ngq	139	5	all	all	DT
cord-018572-e2qq4ngq	139	6	Arf	Arf	NNP
cord-018572-e2qq4ngq	139	7	proteins	protein	NNS
cord-018572-e2qq4ngq	139	8	and	and	CC
cord-018572-e2qq4ngq	139	9	also	also	RB
cord-018572-e2qq4ngq	139	10	by	by	IN
cord-018572-e2qq4ngq	139	11	Arl1	Arl1	NNP
cord-018572-e2qq4ngq	140	1	(	(	-LRB-
cord-018572-e2qq4ngq	140	2	Hong	Hong	NNP
cord-018572-e2qq4ngq	140	3	et	et	NNP
cord-018572-e2qq4ngq	140	4	al	al	NNP
cord-018572-e2qq4ngq	140	5	.	.	NNP
cord-018572-e2qq4ngq	140	6	1998	1998	CD
cord-018572-e2qq4ngq	140	7	)	)	-RRB-
cord-018572-e2qq4ngq	140	8	.	.	.
cord-018572-e2qq4ngq	141	1	PLD	PLD	NNP
cord-018572-e2qq4ngq	141	2	activation	activation	NN
cord-018572-e2qq4ngq	141	3	by	by	IN
cord-018572-e2qq4ngq	141	4	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	141	5	is	be	VBZ
cord-018572-e2qq4ngq	141	6	involved	involve	VBN
cord-018572-e2qq4ngq	141	7	in	in	IN
cord-018572-e2qq4ngq	141	8	a	a	DT
cord-018572-e2qq4ngq	141	9	number	number	NN
cord-018572-e2qq4ngq	141	10	of	of	IN
cord-018572-e2qq4ngq	141	11	processes	process	NNS
cord-018572-e2qq4ngq	141	12	at	at	IN
cord-018572-e2qq4ngq	141	13	the	the	DT
cord-018572-e2qq4ngq	141	14	cell	cell	NN
cord-018572-e2qq4ngq	141	15	periphery	periphery	NN
cord-018572-e2qq4ngq	141	16	,	,	,
cord-018572-e2qq4ngq	141	17	including	include	VBG
cord-018572-e2qq4ngq	141	18	regulated	regulate	VBN
cord-018572-e2qq4ngq	141	19	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	141	20	and	and	CC
cord-018572-e2qq4ngq	141	21	cell	cell	NN
cord-018572-e2qq4ngq	141	22	migration	migration	NN
cord-018572-e2qq4ngq	142	1	(	(	-LRB-
cord-018572-e2qq4ngq	142	2	D'Souza	D'Souza	NNP
cord-018572-e2qq4ngq	142	3	-	-	HYPH
cord-018572-e2qq4ngq	142	4	Schorey	Schorey	NNP
cord-018572-e2qq4ngq	142	5	and	and	CC
cord-018572-e2qq4ngq	142	6	Chavrier	Chavrier	NNP
cord-018572-e2qq4ngq	142	7	2006	2006	CD
cord-018572-e2qq4ngq	142	8	)	)	-RRB-
cord-018572-e2qq4ngq	142	9	.	.	.
cord-018572-e2qq4ngq	143	1	Another	another	DT
cord-018572-e2qq4ngq	143	2	major	major	JJ
cord-018572-e2qq4ngq	143	3	function	function	NN
cord-018572-e2qq4ngq	143	4	of	of	IN
cord-018572-e2qq4ngq	143	5	Arf	Arf	NNP
cord-018572-e2qq4ngq	143	6	proteins	protein	NNS
cord-018572-e2qq4ngq	143	7	is	be	VBZ
cord-018572-e2qq4ngq	143	8	regulation	regulation	NN
cord-018572-e2qq4ngq	143	9	of	of	IN
cord-018572-e2qq4ngq	143	10	phosphoinositide	phosphoinositide	JJ
cord-018572-e2qq4ngq	143	11	levels	level	NNS
cord-018572-e2qq4ngq	143	12	in	in	IN
cord-018572-e2qq4ngq	143	13	cells	cell	NNS
cord-018572-e2qq4ngq	143	14	.	.	.
cord-018572-e2qq4ngq	144	1	All	all	DT
cord-018572-e2qq4ngq	144	2	Arf	Arf	NNP
cord-018572-e2qq4ngq	144	3	proteins	protein	NNS
cord-018572-e2qq4ngq	144	4	can	can	MD
cord-018572-e2qq4ngq	144	5	both	both	DT
cord-018572-e2qq4ngq	144	6	recruit	recruit	VB
cord-018572-e2qq4ngq	144	7	to	to	IN
cord-018572-e2qq4ngq	144	8	membranes	membrane	NNS
cord-018572-e2qq4ngq	144	9	and	and	CC
cord-018572-e2qq4ngq	144	10	stimulate	stimulate	VB
cord-018572-e2qq4ngq	144	11	the	the	DT
cord-018572-e2qq4ngq	144	12	activity	activity	NN
cord-018572-e2qq4ngq	144	13	of	of	IN
cord-018572-e2qq4ngq	144	14	phosphatidylinositol	phosphatidylinositol	JJ
cord-018572-e2qq4ngq	144	15	4-phosphate	4-phosphate	CD
cord-018572-e2qq4ngq	144	16	,	,	,
cord-018572-e2qq4ngq	144	17	5-kinase	5-kinase	CD
cord-018572-e2qq4ngq	144	18	(	(	-LRB-
cord-018572-e2qq4ngq	144	19	PIP5	PIP5	NNP
cord-018572-e2qq4ngq	144	20	K	K	NNP
cord-018572-e2qq4ngq	144	21	)	)	-RRB-
cord-018572-e2qq4ngq	144	22	,	,	.
cord-018572-e2qq4ngq	145	1	an	an	DT
cord-018572-e2qq4ngq	145	2	enzyme	enzyme	NN
cord-018572-e2qq4ngq	145	3	that	that	WDT
cord-018572-e2qq4ngq	145	4	phosphorylates	phosphorylate	VBZ
cord-018572-e2qq4ngq	145	5	inositol	inositol	NN
cord-018572-e2qq4ngq	145	6	4-phosphate	4-phosphate	CD
cord-018572-e2qq4ngq	145	7	(	(	-LRB-
cord-018572-e2qq4ngq	145	8	PI4P	PI4P	NNP
cord-018572-e2qq4ngq	145	9	)	)	-RRB-
cord-018572-e2qq4ngq	145	10	at	at	IN
cord-018572-e2qq4ngq	145	11	the	the	DT
cord-018572-e2qq4ngq	145	12	5-position	5-position	CD
cord-018572-e2qq4ngq	145	13	to	to	TO
cord-018572-e2qq4ngq	145	14	generate	generate	VB
cord-018572-e2qq4ngq	145	15	phosphatidylinositol	phosphatidylinositol	NN
cord-018572-e2qq4ngq	145	16	4,5-bisphosphate	4,5-bisphosphate	CD
cord-018572-e2qq4ngq	145	17	(	(	-LRB-
cord-018572-e2qq4ngq	145	18	PI(4,5)P	PI(4,5)P	NNP
cord-018572-e2qq4ngq	145	19	2	2	CD
cord-018572-e2qq4ngq	145	20	)	)	-RRB-
cord-018572-e2qq4ngq	146	1	(	(	-LRB-
cord-018572-e2qq4ngq	146	2	Honda	Honda	NNP
cord-018572-e2qq4ngq	146	3	et	et	NNP
cord-018572-e2qq4ngq	146	4	al	al	NNP
cord-018572-e2qq4ngq	146	5	.	.	.
cord-018572-e2qq4ngq	146	6	1999	1999	CD
cord-018572-e2qq4ngq	146	7	)	)	-RRB-
cord-018572-e2qq4ngq	146	8	.	.	.
cord-018572-e2qq4ngq	147	1	In	in	IN
cord-018572-e2qq4ngq	147	2	cells	cell	NNS
cord-018572-e2qq4ngq	147	3	,	,	,
cord-018572-e2qq4ngq	147	4	it	-PRON-	PRP
cord-018572-e2qq4ngq	147	5	is	be	VBZ
cord-018572-e2qq4ngq	147	6	primarily	primarily	RB
cord-018572-e2qq4ngq	147	7	Arf6	arf6	JJ
cord-018572-e2qq4ngq	147	8	that	that	WDT
cord-018572-e2qq4ngq	147	9	colocalizes	colocalize	VBZ
cord-018572-e2qq4ngq	147	10	with	with	IN
cord-018572-e2qq4ngq	147	11	PIP5	PIP5	NNP
cord-018572-e2qq4ngq	147	12	K	K	NNP
cord-018572-e2qq4ngq	147	13	at	at	IN
cord-018572-e2qq4ngq	147	14	the	the	DT
cord-018572-e2qq4ngq	147	15	PM	pm	NN
cord-018572-e2qq4ngq	147	16	to	to	TO
cord-018572-e2qq4ngq	147	17	generate	generate	VB
cord-018572-e2qq4ngq	147	18	PI(4,5)P	PI(4,5)P	NNP
cord-018572-e2qq4ngq	147	19	2	2	CD
cord-018572-e2qq4ngq	147	20	,	,	,
cord-018572-e2qq4ngq	147	21	which	which	WDT
cord-018572-e2qq4ngq	147	22	in	in	IN
cord-018572-e2qq4ngq	147	23	turn	turn	NN
cord-018572-e2qq4ngq	147	24	stimulates	stimulate	VBZ
cord-018572-e2qq4ngq	147	25	PM	pm	NN
cord-018572-e2qq4ngq	147	26	ruffling	ruffle	VBG
cord-018572-e2qq4ngq	147	27	(	(	-LRB-
cord-018572-e2qq4ngq	147	28	Honda	Honda	NNP
cord-018572-e2qq4ngq	147	29	et	et	NNP
cord-018572-e2qq4ngq	147	30	al	al	NNP
cord-018572-e2qq4ngq	147	31	.	.	.
cord-018572-e2qq4ngq	147	32	1999	1999	CD
cord-018572-e2qq4ngq	147	33	)	)	-RRB-
cord-018572-e2qq4ngq	147	34	.	.	.
cord-018572-e2qq4ngq	148	1	At	at	IN
cord-018572-e2qq4ngq	148	2	the	the	DT
cord-018572-e2qq4ngq	148	3	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	148	4	,	,	,
cord-018572-e2qq4ngq	148	5	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	148	6	recruits	recruit	VBZ
cord-018572-e2qq4ngq	148	7	and	and	CC
cord-018572-e2qq4ngq	148	8	stimulates	stimulate	VBZ
cord-018572-e2qq4ngq	148	9	the	the	DT
cord-018572-e2qq4ngq	148	10	activity	activity	NN
cord-018572-e2qq4ngq	148	11	of	of	IN
cord-018572-e2qq4ngq	148	12	phosphatidylinositol	phosphatidylinositol	JJ
cord-018572-e2qq4ngq	148	13	4-kinase	4-kinase	CD
cord-018572-e2qq4ngq	148	14	,	,	,
cord-018572-e2qq4ngq	148	15	forming	form	VBG
cord-018572-e2qq4ngq	148	16	PI4P	PI4P	NNP
cord-018572-e2qq4ngq	148	17	,	,	,
cord-018572-e2qq4ngq	148	18	an	an	DT
cord-018572-e2qq4ngq	148	19	important	important	JJ
cord-018572-e2qq4ngq	148	20	membrane	membrane	NN
cord-018572-e2qq4ngq	148	21	lipid	lipid	NN
cord-018572-e2qq4ngq	148	22	for	for	IN
cord-018572-e2qq4ngq	148	23	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	148	24	function	function	NN
cord-018572-e2qq4ngq	148	25	(	(	-LRB-
cord-018572-e2qq4ngq	148	26	De	De	NNP
cord-018572-e2qq4ngq	148	27	Matteis	Matteis	NNP
cord-018572-e2qq4ngq	148	28	and	and	CC
cord-018572-e2qq4ngq	148	29	Godi	Godi	NNP
cord-018572-e2qq4ngq	148	30	2004a	2004a	CD
cord-018572-e2qq4ngq	148	31	)	)	-RRB-
cord-018572-e2qq4ngq	148	32	.	.	.
cord-018572-e2qq4ngq	149	1	As	as	IN
cord-018572-e2qq4ngq	149	2	described	describe	VBN
cord-018572-e2qq4ngq	149	3	above	above	RB
cord-018572-e2qq4ngq	149	4	,	,	,
cord-018572-e2qq4ngq	149	5	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	149	6	can	can	MD
cord-018572-e2qq4ngq	149	7	recruit	recruit	VB
cord-018572-e2qq4ngq	149	8	the	the	DT
cord-018572-e2qq4ngq	149	9	COPI	COPI	NNP
cord-018572-e2qq4ngq	149	10	coat	coat	NN
cord-018572-e2qq4ngq	149	11	to	to	IN
cord-018572-e2qq4ngq	149	12	early	early	JJ
cord-018572-e2qq4ngq	149	13	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	149	14	membranes	membrane	NNS
cord-018572-e2qq4ngq	149	15	,	,	,
cord-018572-e2qq4ngq	149	16	as	as	RB
cord-018572-e2qq4ngq	149	17	well	well	RB
cord-018572-e2qq4ngq	149	18	as	as	IN
cord-018572-e2qq4ngq	149	19	the	the	DT
cord-018572-e2qq4ngq	149	20	heterotetrameric	heterotetrameric	NNP
cord-018572-e2qq4ngq	149	21	clathrin	clathrin	NN
cord-018572-e2qq4ngq	149	22	adaptor	adaptor	NN
cord-018572-e2qq4ngq	149	23	complexes	complex	NNS
cord-018572-e2qq4ngq	149	24	(	(	-LRB-
cord-018572-e2qq4ngq	149	25	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	149	26	,	,	,
cord-018572-e2qq4ngq	149	27	AP-3	AP-3	NNP
cord-018572-e2qq4ngq	149	28	,	,	,
cord-018572-e2qq4ngq	149	29	AP-4	AP-4	NNP
cord-018572-e2qq4ngq	149	30	)	)	-RRB-
cord-018572-e2qq4ngq	149	31	and	and	CC
cord-018572-e2qq4ngq	149	32	the	the	DT
cord-018572-e2qq4ngq	149	33	three	three	CD
cord-018572-e2qq4ngq	149	34	monomeric	monomeric	JJ
cord-018572-e2qq4ngq	149	35	adaptors	adaptor	NNS
cord-018572-e2qq4ngq	149	36	(	(	-LRB-
cord-018572-e2qq4ngq	149	37	GGA1	GGA1	NNP
cord-018572-e2qq4ngq	149	38	,	,	,
cord-018572-e2qq4ngq	149	39	GGA2	GGA2	NNP
cord-018572-e2qq4ngq	149	40	,	,	,
cord-018572-e2qq4ngq	149	41	and	and	CC
cord-018572-e2qq4ngq	149	42	GGA3	GGA3	NNP
cord-018572-e2qq4ngq	149	43	)	)	-RRB-
cord-018572-e2qq4ngq	149	44	to	to	IN
cord-018572-e2qq4ngq	149	45	trans	trans	NNP
cord-018572-e2qq4ngq	149	46	-	-	NNP
cord-018572-e2qq4ngq	149	47	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	149	48	,	,	,
cord-018572-e2qq4ngq	149	49	TGN	TGN	NNP
cord-018572-e2qq4ngq	149	50	,	,	,
cord-018572-e2qq4ngq	149	51	and	and	CC
cord-018572-e2qq4ngq	149	52	endosomal	endosomal	NNP
cord-018572-e2qq4ngq	149	53	membranes	membrane	NNS
cord-018572-e2qq4ngq	149	54	.	.	.
cord-018572-e2qq4ngq	150	1	How	how	WRB
cord-018572-e2qq4ngq	150	2	a	a	DT
cord-018572-e2qq4ngq	150	3	single	single	JJ
cord-018572-e2qq4ngq	150	4	Arf	Arf	NNP
cord-018572-e2qq4ngq	150	5	protein	protein	NN
cord-018572-e2qq4ngq	150	6	can	can	MD
cord-018572-e2qq4ngq	150	7	recruit	recruit	VB
cord-018572-e2qq4ngq	150	8	multiple	multiple	JJ
cord-018572-e2qq4ngq	150	9	coats	coat	NNS
cord-018572-e2qq4ngq	150	10	to	to	IN
cord-018572-e2qq4ngq	150	11	different	different	JJ
cord-018572-e2qq4ngq	150	12	membrane	membrane	NN
cord-018572-e2qq4ngq	150	13	sites	site	NNS
cord-018572-e2qq4ngq	150	14	in	in	IN
cord-018572-e2qq4ngq	150	15	cells	cell	NNS
cord-018572-e2qq4ngq	150	16	is	be	VBZ
cord-018572-e2qq4ngq	150	17	still	still	RB
cord-018572-e2qq4ngq	150	18	not	not	RB
cord-018572-e2qq4ngq	150	19	fully	fully	RB
cord-018572-e2qq4ngq	150	20	understood	understand	VBN
cord-018572-e2qq4ngq	150	21	,	,	,
cord-018572-e2qq4ngq	150	22	but	but	CC
cord-018572-e2qq4ngq	150	23	one	one	CD
cord-018572-e2qq4ngq	150	24	important	important	JJ
cord-018572-e2qq4ngq	150	25	contribution	contribution	NN
cord-018572-e2qq4ngq	150	26	to	to	IN
cord-018572-e2qq4ngq	150	27	specificity	specificity	NN
cord-018572-e2qq4ngq	150	28	comes	come	VBZ
cord-018572-e2qq4ngq	150	29	from	from	IN
cord-018572-e2qq4ngq	150	30	the	the	DT
cord-018572-e2qq4ngq	150	31	Arf	Arf	NNP
cord-018572-e2qq4ngq	150	32	GEFs	gef	NNS
cord-018572-e2qq4ngq	150	33	.	.	.
cord-018572-e2qq4ngq	151	1	In	in	IN
cord-018572-e2qq4ngq	151	2	both	both	DT
cord-018572-e2qq4ngq	151	3	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	151	4	and	and	CC
cord-018572-e2qq4ngq	151	5	yeast	yeast	NN
cord-018572-e2qq4ngq	151	6	cells	cell	NNS
cord-018572-e2qq4ngq	151	7	,	,	,
cord-018572-e2qq4ngq	151	8	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	151	9	and	and	CC
cord-018572-e2qq4ngq	151	10	Gea1/2	Gea1/2	NNP
cord-018572-e2qq4ngq	151	11	,	,	,
cord-018572-e2qq4ngq	151	12	respectively	respectively	RB
cord-018572-e2qq4ngq	151	13	,	,	,
cord-018572-e2qq4ngq	151	14	interact	interact	VB
cord-018572-e2qq4ngq	151	15	directly	directly	RB
cord-018572-e2qq4ngq	151	16	with	with	IN
cord-018572-e2qq4ngq	151	17	COPI	COPI	NNP
cord-018572-e2qq4ngq	152	1	(	(	-LRB-
cord-018572-e2qq4ngq	152	2	Deng	Deng	NNP
cord-018572-e2qq4ngq	152	3	et	et	FW
cord-018572-e2qq4ngq	152	4	al	al	NNP
cord-018572-e2qq4ngq	152	5	.	.	.
cord-018572-e2qq4ngq	152	6	2009	2009	CD
cord-018572-e2qq4ngq	152	7	)	)	-RRB-
cord-018572-e2qq4ngq	152	8	,	,	,
cord-018572-e2qq4ngq	152	9	and	and	CC
cord-018572-e2qq4ngq	152	10	knockdown	knockdown	NN
cord-018572-e2qq4ngq	152	11	of	of	IN
cord-018572-e2qq4ngq	152	12	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	152	13	inhibits	inhibit	VBZ
cord-018572-e2qq4ngq	152	14	COPI	COPI	NNP
cord-018572-e2qq4ngq	152	15	recruitment	recruitment	NN
cord-018572-e2qq4ngq	152	16	to	to	IN
cord-018572-e2qq4ngq	152	17	membranes	membrane	NNS
cord-018572-e2qq4ngq	152	18	in	in	IN
cord-018572-e2qq4ngq	152	19	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	152	20	cells	cell	NNS
cord-018572-e2qq4ngq	153	1	(	(	-LRB-
cord-018572-e2qq4ngq	153	2	Deng	Deng	NNP
cord-018572-e2qq4ngq	153	3	et	et	FW
cord-018572-e2qq4ngq	153	4	al	al	NNP
cord-018572-e2qq4ngq	153	5	.	.	.
cord-018572-e2qq4ngq	153	6	2009	2009	CD
cord-018572-e2qq4ngq	154	1	;	;	:
cord-018572-e2qq4ngq	154	2	Ishizaki	Ishizaki	NNP
cord-018572-e2qq4ngq	154	3	et	et	NNP
cord-018572-e2qq4ngq	154	4	al	al	NNP
cord-018572-e2qq4ngq	154	5	.	.	.
cord-018572-e2qq4ngq	155	1	2008	2008	CD
cord-018572-e2qq4ngq	155	2	;	;	:
cord-018572-e2qq4ngq	155	3	Manolea	Manolea	NNP
cord-018572-e2qq4ngq	155	4	et	et	NNP
cord-018572-e2qq4ngq	155	5	al	al	NNP
cord-018572-e2qq4ngq	155	6	.	.	.
cord-018572-e2qq4ngq	156	1	2008	2008	CD
cord-018572-e2qq4ngq	156	2	;	;	:
cord-018572-e2qq4ngq	156	3	Szul	Szul	NNP
cord-018572-e2qq4ngq	156	4	et	et	NNP
cord-018572-e2qq4ngq	156	5	al	al	NNP
cord-018572-e2qq4ngq	156	6	.	.	NNP
cord-018572-e2qq4ngq	156	7	2007	2007	CD
cord-018572-e2qq4ngq	156	8	)	)	-RRB-
cord-018572-e2qq4ngq	156	9	.	.	.
cord-018572-e2qq4ngq	157	1	In	in	IN
cord-018572-e2qq4ngq	157	2	contrast	contrast	NN
cord-018572-e2qq4ngq	157	3	,	,	,
cord-018572-e2qq4ngq	157	4	knockdown	knockdown	NN
cord-018572-e2qq4ngq	157	5	of	of	IN
cord-018572-e2qq4ngq	157	6	BIG1	BIG1	NNP
cord-018572-e2qq4ngq	157	7	and	and	CC
cord-018572-e2qq4ngq	157	8	BIG2	BIG2	NNP
cord-018572-e2qq4ngq	157	9	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	157	10	GEFs	gefs	NN
cord-018572-e2qq4ngq	157	11	inhibits	inhibit	VBZ
cord-018572-e2qq4ngq	157	12	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	157	13	and	and	CC
cord-018572-e2qq4ngq	157	14	GGA	GGA	NNP
cord-018572-e2qq4ngq	157	15	recruitment	recruitment	NN
cord-018572-e2qq4ngq	157	16	to	to	IN
cord-018572-e2qq4ngq	157	17	the	the	DT
cord-018572-e2qq4ngq	157	18	trans	trans	NNP
cord-018572-e2qq4ngq	157	19	-	-	NNP
cord-018572-e2qq4ngq	157	20	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	157	21	(	(	-LRB-
cord-018572-e2qq4ngq	157	22	Ishizaki	Ishizaki	NNP
cord-018572-e2qq4ngq	157	23	et	et	NNP
cord-018572-e2qq4ngq	157	24	al	al	NNP
cord-018572-e2qq4ngq	157	25	.	.	NNP
cord-018572-e2qq4ngq	157	26	2008	2008	CD
cord-018572-e2qq4ngq	157	27	;	;	:
cord-018572-e2qq4ngq	157	28	Manolea	Manolea	NNP
cord-018572-e2qq4ngq	157	29	et	et	NNP
cord-018572-e2qq4ngq	157	30	al	al	NNP
cord-018572-e2qq4ngq	157	31	.	.	NNP
cord-018572-e2qq4ngq	157	32	2008	2008	CD
cord-018572-e2qq4ngq	157	33	)	)	-RRB-
cord-018572-e2qq4ngq	157	34	.	.	.
cord-018572-e2qq4ngq	158	1	In	in	IN
cord-018572-e2qq4ngq	158	2	yeast	yeast	NN
cord-018572-e2qq4ngq	158	3	,	,	,
cord-018572-e2qq4ngq	158	4	a	a	DT
cord-018572-e2qq4ngq	158	5	single	single	JJ
cord-018572-e2qq4ngq	158	6	class	class	NN
cord-018572-e2qq4ngq	158	7	I	-PRON-	PRP
cord-018572-e2qq4ngq	158	8	Arf	Arf	NNP
cord-018572-e2qq4ngq	158	9	is	be	VBZ
cord-018572-e2qq4ngq	158	10	responsible	responsible	JJ
cord-018572-e2qq4ngq	158	11	for	for	IN
cord-018572-e2qq4ngq	158	12	recruiting	recruit	VBG
cord-018572-e2qq4ngq	158	13	COPI	COPI	NNP
cord-018572-e2qq4ngq	158	14	,	,	,
cord-018572-e2qq4ngq	158	15	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	158	16	,	,	,
cord-018572-e2qq4ngq	158	17	and	and	CC
cord-018572-e2qq4ngq	158	18	GGA	GGA	NNP
cord-018572-e2qq4ngq	158	19	coats	coat	NNS
cord-018572-e2qq4ngq	158	20	to	to	IN
cord-018572-e2qq4ngq	158	21	membranes	membrane	NNS
cord-018572-e2qq4ngq	158	22	in	in	IN
cord-018572-e2qq4ngq	158	23	cells	cell	NNS
cord-018572-e2qq4ngq	158	24	,	,	,
cord-018572-e2qq4ngq	158	25	and	and	CC
cord-018572-e2qq4ngq	158	26	hence	hence	RB
cord-018572-e2qq4ngq	158	27	mechanisms	mechanism	NNS
cord-018572-e2qq4ngq	158	28	such	such	JJ
cord-018572-e2qq4ngq	158	29	as	as	IN
cord-018572-e2qq4ngq	158	30	Arf	Arf	NNP
cord-018572-e2qq4ngq	158	31	GEF	GEF	NNP
cord-018572-e2qq4ngq	158	32	-	-	HYPH
cord-018572-e2qq4ngq	158	33	mediated	mediate	VBN
cord-018572-e2qq4ngq	158	34	specificity	specificity	NN
cord-018572-e2qq4ngq	158	35	are	be	VBP
cord-018572-e2qq4ngq	158	36	required	require	VBN
cord-018572-e2qq4ngq	158	37	.	.	.
cord-018572-e2qq4ngq	159	1	In	in	IN
cord-018572-e2qq4ngq	159	2	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	159	3	cells	cell	NNS
cord-018572-e2qq4ngq	159	4	,	,	,
cord-018572-e2qq4ngq	159	5	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	159	6	3	3	CD
cord-018572-e2qq4ngq	159	7	-	-	SYM
cord-018572-e2qq4ngq	159	8	5	5	CD
cord-018572-e2qq4ngq	159	9	could	could	MD
cord-018572-e2qq4ngq	159	10	contribute	contribute	VB
cord-018572-e2qq4ngq	159	11	an	an	DT
cord-018572-e2qq4ngq	159	12	additional	additional	JJ
cord-018572-e2qq4ngq	159	13	layer	layer	NN
cord-018572-e2qq4ngq	159	14	of	of	IN
cord-018572-e2qq4ngq	159	15	specificity	specificity	NN
cord-018572-e2qq4ngq	159	16	.	.	.
cord-018572-e2qq4ngq	160	1	It	-PRON-	PRP
cord-018572-e2qq4ngq	160	2	has	have	VBZ
cord-018572-e2qq4ngq	160	3	been	be	VBN
cord-018572-e2qq4ngq	160	4	shown	show	VBN
cord-018572-e2qq4ngq	160	5	recently	recently	RB
cord-018572-e2qq4ngq	160	6	that	that	IN
cord-018572-e2qq4ngq	160	7	a	a	DT
cord-018572-e2qq4ngq	160	8	specific	specific	JJ
cord-018572-e2qq4ngq	160	9	subset	subset	NN
cord-018572-e2qq4ngq	160	10	of	of	IN
cord-018572-e2qq4ngq	160	11	Arf	Arf	NNP
cord-018572-e2qq4ngq	160	12	family	family	NN
cord-018572-e2qq4ngq	160	13	members	member	NNS
cord-018572-e2qq4ngq	160	14	(	(	-LRB-
cord-018572-e2qq4ngq	160	15	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	160	16	,	,	,
cord-018572-e2qq4ngq	160	17	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	160	18	,	,	,
cord-018572-e2qq4ngq	160	19	and	and	CC
cord-018572-e2qq4ngq	160	20	Arf5	Arf5	NNP
cord-018572-e2qq4ngq	160	21	,	,	,
cord-018572-e2qq4ngq	160	22	but	but	CC
cord-018572-e2qq4ngq	160	23	not	not	RB
cord-018572-e2qq4ngq	160	24	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	160	25	or	or	CC
cord-018572-e2qq4ngq	160	26	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	160	27	)	)	-RRB-
cord-018572-e2qq4ngq	160	28	are	be	VBP
cord-018572-e2qq4ngq	160	29	incorporated	incorporate	VBN
cord-018572-e2qq4ngq	160	30	into	into	IN
cord-018572-e2qq4ngq	160	31	COPI	COPI	NNP
cord-018572-e2qq4ngq	160	32	vesicles	vesicle	NNS
cord-018572-e2qq4ngq	160	33	reconstituted	reconstitute	VBN
cord-018572-e2qq4ngq	160	34	using	use	VBG
cord-018572-e2qq4ngq	160	35	cytosol	cytosol	NN
cord-018572-e2qq4ngq	160	36	(	(	-LRB-
cord-018572-e2qq4ngq	160	37	Popoff	Popoff	NNP
cord-018572-e2qq4ngq	160	38	et	et	NNP
cord-018572-e2qq4ngq	160	39	al	al	NNP
cord-018572-e2qq4ngq	160	40	.	.	NNP
cord-018572-e2qq4ngq	160	41	2011	2011	CD
cord-018572-e2qq4ngq	160	42	)	)	-RRB-
cord-018572-e2qq4ngq	160	43	.	.	.
cord-018572-e2qq4ngq	161	1	A	a	DT
cord-018572-e2qq4ngq	161	2	full	full	JJ
cord-018572-e2qq4ngq	161	3	understanding	understanding	NN
cord-018572-e2qq4ngq	161	4	of	of	IN
cord-018572-e2qq4ngq	161	5	the	the	DT
cord-018572-e2qq4ngq	161	6	mechanisms	mechanism	NNS
cord-018572-e2qq4ngq	161	7	determining	determine	VBG
cord-018572-e2qq4ngq	161	8	the	the	DT
cord-018572-e2qq4ngq	161	9	specificity	specificity	NN
cord-018572-e2qq4ngq	161	10	of	of	IN
cord-018572-e2qq4ngq	161	11	coat	coat	NN
cord-018572-e2qq4ngq	161	12	recruitment	recruitment	NN
cord-018572-e2qq4ngq	161	13	by	by	IN
cord-018572-e2qq4ngq	161	14	Arf	Arf	NNP
cord-018572-e2qq4ngq	161	15	family	family	NN
cord-018572-e2qq4ngq	161	16	members	member	NNS
cord-018572-e2qq4ngq	161	17	and	and	CC
cord-018572-e2qq4ngq	161	18	their	-PRON-	PRP$
cord-018572-e2qq4ngq	161	19	regulators	regulator	NNS
cord-018572-e2qq4ngq	161	20	is	be	VBZ
cord-018572-e2qq4ngq	161	21	an	an	DT
cord-018572-e2qq4ngq	161	22	important	important	JJ
cord-018572-e2qq4ngq	161	23	open	open	JJ
cord-018572-e2qq4ngq	161	24	question	question	NN
cord-018572-e2qq4ngq	161	25	in	in	IN
cord-018572-e2qq4ngq	161	26	the	the	DT
cord-018572-e2qq4ngq	161	27	field	field	NN
cord-018572-e2qq4ngq	161	28	.	.	.
cord-018572-e2qq4ngq	162	1	Important	important	JJ
cord-018572-e2qq4ngq	162	2	insights	insight	NNS
cord-018572-e2qq4ngq	162	3	into	into	IN
cord-018572-e2qq4ngq	162	4	the	the	DT
cord-018572-e2qq4ngq	162	5	recruitment	recruitment	NN
cord-018572-e2qq4ngq	162	6	of	of	IN
cord-018572-e2qq4ngq	162	7	coats	coat	NNS
cord-018572-e2qq4ngq	162	8	by	by	IN
cord-018572-e2qq4ngq	162	9	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	162	10	have	have	VBP
cord-018572-e2qq4ngq	162	11	come	come	VBN
cord-018572-e2qq4ngq	162	12	from	from	IN
cord-018572-e2qq4ngq	162	13	recent	recent	JJ
cord-018572-e2qq4ngq	162	14	structural	structural	JJ
cord-018572-e2qq4ngq	162	15	studies	study	NNS
cord-018572-e2qq4ngq	162	16	(	(	-LRB-
cord-018572-e2qq4ngq	162	17	Ren	Ren	NNP
cord-018572-e2qq4ngq	162	18	et	et	NNP
cord-018572-e2qq4ngq	162	19	al	al	NNP
cord-018572-e2qq4ngq	162	20	.	.	NNP
cord-018572-e2qq4ngq	162	21	2013	2013	CD
cord-018572-e2qq4ngq	162	22	;	;	:
cord-018572-e2qq4ngq	162	23	Yu	Yu	NNP
cord-018572-e2qq4ngq	162	24	et	et	NNP
cord-018572-e2qq4ngq	162	25	al	al	NNP
cord-018572-e2qq4ngq	162	26	.	.	NNP
cord-018572-e2qq4ngq	162	27	2012	2012	CD
cord-018572-e2qq4ngq	162	28	)	)	-RRB-
cord-018572-e2qq4ngq	162	29	.	.	.
cord-018572-e2qq4ngq	163	1	The	the	DT
cord-018572-e2qq4ngq	163	2	structure	structure	NN
cord-018572-e2qq4ngq	163	3	of	of	IN
cord-018572-e2qq4ngq	163	4	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	163	5	bound	bind	VBN
cord-018572-e2qq4ngq	163	6	to	to	IN
cord-018572-e2qq4ngq	163	7	a	a	DT
cord-018572-e2qq4ngq	163	8	subcomplex	subcomplex	NN
cord-018572-e2qq4ngq	163	9	of	of	IN
cord-018572-e2qq4ngq	163	10	the	the	DT
cord-018572-e2qq4ngq	163	11	COPI	COPI	NNP
cord-018572-e2qq4ngq	163	12	coat	coat	NN
cord-018572-e2qq4ngq	163	13	revealed	reveal	VBD
cord-018572-e2qq4ngq	163	14	a	a	DT
cord-018572-e2qq4ngq	163	15	binding	binding	JJ
cord-018572-e2qq4ngq	163	16	site	site	NN
cord-018572-e2qq4ngq	163	17	on	on	IN
cord-018572-e2qq4ngq	163	18	the	the	DT
cord-018572-e2qq4ngq	163	19	γ	γ	NN
cord-018572-e2qq4ngq	163	20	subunit	subunit	NN
cord-018572-e2qq4ngq	163	21	,	,	,
cord-018572-e2qq4ngq	163	22	which	which	WDT
cord-018572-e2qq4ngq	163	23	would	would	MD
cord-018572-e2qq4ngq	163	24	position	position	VB
cord-018572-e2qq4ngq	163	25	the	the	DT
cord-018572-e2qq4ngq	163	26	entire	entire	JJ
cord-018572-e2qq4ngq	163	27	COPI	COPI	NNP
cord-018572-e2qq4ngq	163	28	complex	complex	JJ
cord-018572-e2qq4ngq	163	29	on	on	IN
cord-018572-e2qq4ngq	163	30	the	the	DT
cord-018572-e2qq4ngq	163	31	membrane	membrane	NN
cord-018572-e2qq4ngq	163	32	surface	surface	NN
cord-018572-e2qq4ngq	163	33	in	in	IN
cord-018572-e2qq4ngq	163	34	a	a	DT
cord-018572-e2qq4ngq	163	35	conformation	conformation	NN
cord-018572-e2qq4ngq	163	36	very	very	RB
cord-018572-e2qq4ngq	163	37	similar	similar	JJ
cord-018572-e2qq4ngq	163	38	to	to	IN
cord-018572-e2qq4ngq	163	39	the	the	DT
cord-018572-e2qq4ngq	163	40	membrane	membrane	NN
cord-018572-e2qq4ngq	163	41	-	-	HYPH
cord-018572-e2qq4ngq	163	42	bound	bind	VBN
cord-018572-e2qq4ngq	163	43	AP-2	AP-2	NNP
cord-018572-e2qq4ngq	163	44	/	/	SYM
cord-018572-e2qq4ngq	163	45	clathrin	clathrin	NN
cord-018572-e2qq4ngq	163	46	complex	complex	NN
cord-018572-e2qq4ngq	163	47	(	(	-LRB-
cord-018572-e2qq4ngq	163	48	Yu	Yu	NNP
cord-018572-e2qq4ngq	163	49	et	et	FW
cord-018572-e2qq4ngq	163	50	al	al	NNP
cord-018572-e2qq4ngq	163	51	.	.	NNP
cord-018572-e2qq4ngq	163	52	2012	2012	CD
cord-018572-e2qq4ngq	163	53	)	)	-RRB-
cord-018572-e2qq4ngq	163	54	.	.	.
cord-018572-e2qq4ngq	164	1	COPI	COPI	NNP
cord-018572-e2qq4ngq	164	2	,	,	,
cord-018572-e2qq4ngq	164	3	AP-2	AP-2	NNP
cord-018572-e2qq4ngq	164	4	/	/	SYM
cord-018572-e2qq4ngq	164	5	clathrin	clathrin	NN
cord-018572-e2qq4ngq	164	6	,	,	,
cord-018572-e2qq4ngq	164	7	and	and	CC
cord-018572-e2qq4ngq	164	8	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	164	9	/	/	SYM
cord-018572-e2qq4ngq	164	10	clathrin	clathrin	NN
cord-018572-e2qq4ngq	164	11	complexes	complex	NNS
cord-018572-e2qq4ngq	164	12	share	share	VBP
cord-018572-e2qq4ngq	164	13	a	a	DT
cord-018572-e2qq4ngq	164	14	remarkable	remarkable	JJ
cord-018572-e2qq4ngq	164	15	level	level	NN
cord-018572-e2qq4ngq	164	16	of	of	IN
cord-018572-e2qq4ngq	164	17	structural	structural	JJ
cord-018572-e2qq4ngq	164	18	similarity	similarity	NN
cord-018572-e2qq4ngq	164	19	,	,	,
cord-018572-e2qq4ngq	164	20	although	although	IN
cord-018572-e2qq4ngq	164	21	AP-2	AP-2	NNP
cord-018572-e2qq4ngq	164	22	is	be	VBZ
cord-018572-e2qq4ngq	164	23	recruited	recruit	VBN
cord-018572-e2qq4ngq	164	24	to	to	IN
cord-018572-e2qq4ngq	164	25	membranes	membrane	NNS
cord-018572-e2qq4ngq	164	26	by	by	IN
cord-018572-e2qq4ngq	164	27	plasma	plasma	NN
cord-018572-e2qq4ngq	164	28	membrane	membrane	NN
cord-018572-e2qq4ngq	164	29	PI(4,5)P	PI(4,5)P	NNP
cord-018572-e2qq4ngq	164	30	2	2	CD
cord-018572-e2qq4ngq	164	31	rather	rather	RB
cord-018572-e2qq4ngq	164	32	than	than	IN
cord-018572-e2qq4ngq	164	33	an	an	DT
cord-018572-e2qq4ngq	164	34	activated	activate	VBN
cord-018572-e2qq4ngq	164	35	Arf	Arf	NNP
cord-018572-e2qq4ngq	164	36	protein	protein	NN
cord-018572-e2qq4ngq	164	37	(	(	-LRB-
cord-018572-e2qq4ngq	164	38	Jackson	Jackson	NNP
cord-018572-e2qq4ngq	164	39	et	et	NNP
cord-018572-e2qq4ngq	164	40	al	al	NNP
cord-018572-e2qq4ngq	164	41	.	.	NNP
cord-018572-e2qq4ngq	164	42	2010	2010	CD
cord-018572-e2qq4ngq	164	43	)	)	-RRB-
cord-018572-e2qq4ngq	164	44	.	.	.
cord-018572-e2qq4ngq	165	1	All	all	DT
cord-018572-e2qq4ngq	165	2	of	of	IN
cord-018572-e2qq4ngq	165	3	these	these	DT
cord-018572-e2qq4ngq	165	4	coats	coat	NNS
cord-018572-e2qq4ngq	165	5	have	have	VBP
cord-018572-e2qq4ngq	165	6	two	two	CD
cord-018572-e2qq4ngq	165	7	large	large	JJ
cord-018572-e2qq4ngq	165	8	subunits	subunit	NNS
cord-018572-e2qq4ngq	165	9	that	that	WDT
cord-018572-e2qq4ngq	165	10	are	be	VBP
cord-018572-e2qq4ngq	165	11	symmetrically	symmetrically	RB
cord-018572-e2qq4ngq	165	12	located	locate	VBN
cord-018572-e2qq4ngq	165	13	within	within	IN
cord-018572-e2qq4ngq	165	14	the	the	DT
cord-018572-e2qq4ngq	165	15	complex	complex	NN
cord-018572-e2qq4ngq	165	16	,	,	,
cord-018572-e2qq4ngq	165	17	which	which	WDT
cord-018572-e2qq4ngq	165	18	in	in	IN
cord-018572-e2qq4ngq	165	19	the	the	DT
cord-018572-e2qq4ngq	165	20	case	case	NN
cord-018572-e2qq4ngq	165	21	of	of	IN
cord-018572-e2qq4ngq	165	22	COPI	COPI	NNP
cord-018572-e2qq4ngq	165	23	are	be	VBP
cord-018572-e2qq4ngq	165	24	the	the	DT
cord-018572-e2qq4ngq	165	25	β	β	NN
cord-018572-e2qq4ngq	165	26	and	and	CC
cord-018572-e2qq4ngq	165	27	γ	γ	NN
cord-018572-e2qq4ngq	165	28	subunits	subunit	NNS
cord-018572-e2qq4ngq	165	29	.	.	.
cord-018572-e2qq4ngq	166	1	Biochemical	biochemical	JJ
cord-018572-e2qq4ngq	166	2	studies	study	NNS
cord-018572-e2qq4ngq	166	3	confirmed	confirm	VBD
cord-018572-e2qq4ngq	166	4	a	a	DT
cord-018572-e2qq4ngq	166	5	second	second	JJ
cord-018572-e2qq4ngq	166	6	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	166	7	binding	bind	VBG
cord-018572-e2qq4ngq	166	8	site	site	NN
cord-018572-e2qq4ngq	166	9	on	on	IN
cord-018572-e2qq4ngq	166	10	the	the	DT
cord-018572-e2qq4ngq	166	11	β	β	XX
cord-018572-e2qq4ngq	166	12	subunit	subunit	NN
cord-018572-e2qq4ngq	166	13	of	of	IN
cord-018572-e2qq4ngq	166	14	COPI	COPI	NNP
cord-018572-e2qq4ngq	167	1	(	(	-LRB-
cord-018572-e2qq4ngq	167	2	Yu	Yu	NNP
cord-018572-e2qq4ngq	167	3	et	et	NNP
cord-018572-e2qq4ngq	167	4	al	al	NNP
cord-018572-e2qq4ngq	167	5	.	.	NNP
cord-018572-e2qq4ngq	167	6	2012	2012	CD
cord-018572-e2qq4ngq	167	7	)	)	-RRB-
cord-018572-e2qq4ngq	167	8	.	.	.
cord-018572-e2qq4ngq	168	1	The	the	DT
cord-018572-e2qq4ngq	168	2	structure	structure	NN
cord-018572-e2qq4ngq	168	3	of	of	IN
cord-018572-e2qq4ngq	168	4	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	168	5	in	in	IN
cord-018572-e2qq4ngq	168	6	complex	complex	NN
cord-018572-e2qq4ngq	168	7	with	with	IN
cord-018572-e2qq4ngq	168	8	the	the	DT
cord-018572-e2qq4ngq	168	9	entire	entire	JJ
cord-018572-e2qq4ngq	168	10	central	central	JJ
cord-018572-e2qq4ngq	168	11	trunk	trunk	NN
cord-018572-e2qq4ngq	168	12	region	region	NN
cord-018572-e2qq4ngq	168	13	of	of	IN
cord-018572-e2qq4ngq	168	14	the	the	DT
cord-018572-e2qq4ngq	168	15	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	168	16	adaptor	adaptor	NN
cord-018572-e2qq4ngq	168	17	complex	complex	NN
cord-018572-e2qq4ngq	168	18	revealed	reveal	VBD
cord-018572-e2qq4ngq	168	19	only	only	RB
cord-018572-e2qq4ngq	168	20	one	one	CD
cord-018572-e2qq4ngq	168	21	of	of	IN
cord-018572-e2qq4ngq	168	22	the	the	DT
cord-018572-e2qq4ngq	168	23	two	two	CD
cord-018572-e2qq4ngq	168	24	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	168	25	binding	bind	VBG
cord-018572-e2qq4ngq	168	26	sites	site	NNS
cord-018572-e2qq4ngq	168	27	on	on	IN
cord-018572-e2qq4ngq	168	28	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	168	29	,	,	,
cord-018572-e2qq4ngq	168	30	on	on	IN
cord-018572-e2qq4ngq	168	31	the	the	DT
cord-018572-e2qq4ngq	168	32	β1	β1	NNP
cord-018572-e2qq4ngq	168	33	subunit	subunit	NN
cord-018572-e2qq4ngq	169	1	(	(	-LRB-
cord-018572-e2qq4ngq	169	2	Ren	Ren	NNP
cord-018572-e2qq4ngq	169	3	et	et	NNP
cord-018572-e2qq4ngq	169	4	al	al	NNP
cord-018572-e2qq4ngq	169	5	.	.	NNP
cord-018572-e2qq4ngq	169	6	2013	2013	CD
cord-018572-e2qq4ngq	169	7	)	)	-RRB-
cord-018572-e2qq4ngq	169	8	.	.	.
cord-018572-e2qq4ngq	170	1	This	this	DT
cord-018572-e2qq4ngq	170	2	Arf1-AP-1	Arf1-AP-1	NNP
cord-018572-e2qq4ngq	170	3	structure	structure	NN
cord-018572-e2qq4ngq	170	4	is	be	VBZ
cord-018572-e2qq4ngq	170	5	almost	almost	RB
cord-018572-e2qq4ngq	170	6	identical	identical	JJ
cord-018572-e2qq4ngq	170	7	to	to	IN
cord-018572-e2qq4ngq	170	8	the	the	DT
cord-018572-e2qq4ngq	170	9	active	active	JJ
cord-018572-e2qq4ngq	170	10	,	,	,
cord-018572-e2qq4ngq	170	11	cargo	cargo	NN
cord-018572-e2qq4ngq	170	12	-	-	HYPH
cord-018572-e2qq4ngq	170	13	bound	bind	VBN
cord-018572-e2qq4ngq	170	14	AP-2	AP-2	NNP
cord-018572-e2qq4ngq	170	15	complex	complex	JJ
cord-018572-e2qq4ngq	171	1	(	(	-LRB-
cord-018572-e2qq4ngq	171	2	Jackson	Jackson	NNP
cord-018572-e2qq4ngq	171	3	et	et	NNP
cord-018572-e2qq4ngq	171	4	al	al	NNP
cord-018572-e2qq4ngq	171	5	.	.	NNP
cord-018572-e2qq4ngq	171	6	2010	2010	CD
cord-018572-e2qq4ngq	171	7	)	)	-RRB-
cord-018572-e2qq4ngq	171	8	,	,	,
cord-018572-e2qq4ngq	171	9	and	and	CC
cord-018572-e2qq4ngq	171	10	reveals	reveal	VBZ
cord-018572-e2qq4ngq	171	11	a	a	DT
cord-018572-e2qq4ngq	171	12	second	second	JJ
cord-018572-e2qq4ngq	171	13	interaction	interaction	NN
cord-018572-e2qq4ngq	171	14	,	,	,
cord-018572-e2qq4ngq	171	15	involving	involve	VBG
cord-018572-e2qq4ngq	171	16	the	the	DT
cord-018572-e2qq4ngq	171	17	back	back	JJ
cord-018572-e2qq4ngq	171	18	side	side	NN
cord-018572-e2qq4ngq	171	19	of	of	IN
cord-018572-e2qq4ngq	171	20	Arf	Arf	NNP
cord-018572-e2qq4ngq	171	21	,	,	,
cord-018572-e2qq4ngq	171	22	opposite	opposite	IN
cord-018572-e2qq4ngq	171	23	the	the	DT
cord-018572-e2qq4ngq	171	24	switch	switch	NN
cord-018572-e2qq4ngq	171	25	regions	region	NNS
cord-018572-e2qq4ngq	171	26	,	,	,
cord-018572-e2qq4ngq	171	27	to	to	IN
cord-018572-e2qq4ngq	171	28	a	a	DT
cord-018572-e2qq4ngq	171	29	second	second	JJ
cord-018572-e2qq4ngq	171	30	site	site	NN
cord-018572-e2qq4ngq	171	31	on	on	IN
cord-018572-e2qq4ngq	171	32	the	the	DT
cord-018572-e2qq4ngq	171	33	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	171	34	γ	γ	NN
cord-018572-e2qq4ngq	171	35	subunit	subunit	NN
cord-018572-e2qq4ngq	171	36	.	.	.
cord-018572-e2qq4ngq	172	1	Biochemical	biochemical	JJ
cord-018572-e2qq4ngq	172	2	and	and	CC
cord-018572-e2qq4ngq	172	3	cell	cell	NN
cord-018572-e2qq4ngq	172	4	biological	biological	JJ
cord-018572-e2qq4ngq	172	5	analyses	analysis	NNS
cord-018572-e2qq4ngq	172	6	showed	show	VBD
cord-018572-e2qq4ngq	172	7	that	that	IN
cord-018572-e2qq4ngq	172	8	recruitment	recruitment	NN
cord-018572-e2qq4ngq	172	9	of	of	IN
cord-018572-e2qq4ngq	172	10	the	the	DT
cord-018572-e2qq4ngq	172	11	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	172	12	adaptor	adaptor	NN
cord-018572-e2qq4ngq	172	13	to	to	IN
cord-018572-e2qq4ngq	172	14	membranes	membrane	NNS
cord-018572-e2qq4ngq	172	15	requires	require	VBZ
cord-018572-e2qq4ngq	172	16	two	two	CD
cord-018572-e2qq4ngq	172	17	binding	bind	VBG
cord-018572-e2qq4ngq	172	18	sites	site	NNS
cord-018572-e2qq4ngq	172	19	for	for	IN
cord-018572-e2qq4ngq	172	20	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	173	1	(	(	-LRB-
cord-018572-e2qq4ngq	173	2	one	one	CD
cord-018572-e2qq4ngq	173	3	on	on	IN
cord-018572-e2qq4ngq	173	4	each	each	DT
cord-018572-e2qq4ngq	173	5	of	of	IN
cord-018572-e2qq4ngq	173	6	the	the	DT
cord-018572-e2qq4ngq	173	7	symmetrical	symmetrical	JJ
cord-018572-e2qq4ngq	173	8	β1	β1	NNP
cord-018572-e2qq4ngq	173	9	and	and	CC
cord-018572-e2qq4ngq	173	10	γ	γ	NN
cord-018572-e2qq4ngq	173	11	subunits	subunit	NNS
cord-018572-e2qq4ngq	173	12	)	)	-RRB-
cord-018572-e2qq4ngq	173	13	,	,	,
cord-018572-e2qq4ngq	173	14	in	in	IN
cord-018572-e2qq4ngq	173	15	a	a	DT
cord-018572-e2qq4ngq	173	16	manner	manner	NN
cord-018572-e2qq4ngq	173	17	analogous	analogous	JJ
cord-018572-e2qq4ngq	173	18	to	to	IN
cord-018572-e2qq4ngq	173	19	those	those	DT
cord-018572-e2qq4ngq	173	20	found	find	VBN
cord-018572-e2qq4ngq	173	21	for	for	IN
cord-018572-e2qq4ngq	173	22	COPI	COPI	NNP
cord-018572-e2qq4ngq	173	23	.	.	.
cord-018572-e2qq4ngq	174	1	However	however	RB
cord-018572-e2qq4ngq	174	2	,	,	,
cord-018572-e2qq4ngq	174	3	the	the	DT
cord-018572-e2qq4ngq	174	4	conformation	conformation	NN
cord-018572-e2qq4ngq	174	5	of	of	IN
cord-018572-e2qq4ngq	174	6	the	the	DT
cord-018572-e2qq4ngq	174	7	active	active	JJ
cord-018572-e2qq4ngq	174	8	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	174	9	-	-	:
cord-018572-e2qq4ngq	174	10	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	174	11	complex	complex	NN
cord-018572-e2qq4ngq	174	12	docked	dock	VBD
cord-018572-e2qq4ngq	174	13	to	to	IN
cord-018572-e2qq4ngq	174	14	a	a	DT
cord-018572-e2qq4ngq	174	15	membrane	membrane	NN
cord-018572-e2qq4ngq	174	16	bilayer	bilayer	NN
cord-018572-e2qq4ngq	174	17	is	be	VBZ
cord-018572-e2qq4ngq	174	18	not	not	RB
cord-018572-e2qq4ngq	174	19	compatible	compatible	JJ
cord-018572-e2qq4ngq	174	20	with	with	IN
cord-018572-e2qq4ngq	174	21	binding	binding	NN
cord-018572-e2qq4ngq	174	22	of	of	IN
cord-018572-e2qq4ngq	174	23	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	174	24	molecules	molecule	NNS
cord-018572-e2qq4ngq	174	25	at	at	IN
cord-018572-e2qq4ngq	174	26	both	both	DT
cord-018572-e2qq4ngq	174	27	recruitment	recruitment	NN
cord-018572-e2qq4ngq	174	28	sites	site	NNS
cord-018572-e2qq4ngq	174	29	(	(	-LRB-
cord-018572-e2qq4ngq	174	30	Ren	Ren	NNP
cord-018572-e2qq4ngq	174	31	et	et	NNP
cord-018572-e2qq4ngq	174	32	al	al	NNP
cord-018572-e2qq4ngq	174	33	.	.	NNP
cord-018572-e2qq4ngq	174	34	2013	2013	CD
cord-018572-e2qq4ngq	174	35	)	)	-RRB-
cord-018572-e2qq4ngq	174	36	.	.	.
cord-018572-e2qq4ngq	175	1	Hence	hence	RB
cord-018572-e2qq4ngq	175	2	the	the	DT
cord-018572-e2qq4ngq	175	3	proposed	propose	VBN
cord-018572-e2qq4ngq	175	4	model	model	NN
cord-018572-e2qq4ngq	175	5	based	base	VBN
cord-018572-e2qq4ngq	175	6	on	on	IN
cord-018572-e2qq4ngq	175	7	these	these	DT
cord-018572-e2qq4ngq	175	8	results	result	NNS
cord-018572-e2qq4ngq	175	9	is	be	VBZ
cord-018572-e2qq4ngq	175	10	recruitment	recruitment	NN
cord-018572-e2qq4ngq	175	11	of	of	IN
cord-018572-e2qq4ngq	175	12	a	a	DT
cord-018572-e2qq4ngq	175	13	closed	closed	JJ
cord-018572-e2qq4ngq	175	14	conformation	conformation	NN
cord-018572-e2qq4ngq	175	15	of	of	IN
cord-018572-e2qq4ngq	175	16	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	175	17	by	by	IN
cord-018572-e2qq4ngq	175	18	two	two	CD
cord-018572-e2qq4ngq	175	19	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	175	20	molecules	molecule	NNS
cord-018572-e2qq4ngq	175	21	,	,	,
cord-018572-e2qq4ngq	175	22	a	a	DT
cord-018572-e2qq4ngq	175	23	change	change	NN
cord-018572-e2qq4ngq	175	24	in	in	IN
cord-018572-e2qq4ngq	175	25	conformation	conformation	NN
cord-018572-e2qq4ngq	175	26	to	to	IN
cord-018572-e2qq4ngq	175	27	the	the	DT
cord-018572-e2qq4ngq	175	28	open	open	JJ
cord-018572-e2qq4ngq	175	29	cargo	cargo	NN
cord-018572-e2qq4ngq	175	30	-	-	HYPH
cord-018572-e2qq4ngq	175	31	bound	bind	VBN
cord-018572-e2qq4ngq	175	32	form	form	NN
cord-018572-e2qq4ngq	175	33	of	of	IN
cord-018572-e2qq4ngq	175	34	the	the	DT
cord-018572-e2qq4ngq	175	35	adaptor	adaptor	NN
cord-018572-e2qq4ngq	175	36	with	with	IN
cord-018572-e2qq4ngq	175	37	one	one	CD
cord-018572-e2qq4ngq	175	38	molecule	molecule	NN
cord-018572-e2qq4ngq	175	39	of	of	IN
cord-018572-e2qq4ngq	175	40	cargo	cargo	NN
cord-018572-e2qq4ngq	175	41	engaged	engage	VBN
cord-018572-e2qq4ngq	175	42	,	,	,
cord-018572-e2qq4ngq	175	43	and	and	CC
cord-018572-e2qq4ngq	175	44	then	then	RB
cord-018572-e2qq4ngq	175	45	a	a	DT
cord-018572-e2qq4ngq	175	46	large	large	JJ
cord-018572-e2qq4ngq	175	47	conformational	conformational	JJ
cord-018572-e2qq4ngq	175	48	change	change	NN
cord-018572-e2qq4ngq	175	49	mediated	mediate	VBN
cord-018572-e2qq4ngq	175	50	by	by	IN
cord-018572-e2qq4ngq	175	51	binding	bind	VBG
cord-018572-e2qq4ngq	175	52	of	of	IN
cord-018572-e2qq4ngq	175	53	the	the	DT
cord-018572-e2qq4ngq	175	54	trunk	trunk	NN
cord-018572-e2qq4ngq	175	55	of	of	IN
cord-018572-e2qq4ngq	175	56	the	the	DT
cord-018572-e2qq4ngq	175	57	γ	γ	NN
cord-018572-e2qq4ngq	175	58	subunit	subunit	NN
cord-018572-e2qq4ngq	175	59	to	to	IN
cord-018572-e2qq4ngq	175	60	the	the	DT
cord-018572-e2qq4ngq	175	61	back	back	JJ
cord-018572-e2qq4ngq	175	62	side	side	NN
cord-018572-e2qq4ngq	175	63	of	of	IN
cord-018572-e2qq4ngq	175	64	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	175	65	,	,	,
cord-018572-e2qq4ngq	175	66	concomitantly	concomitantly	RB
cord-018572-e2qq4ngq	175	67	releasing	release	VBG
cord-018572-e2qq4ngq	175	68	the	the	DT
cord-018572-e2qq4ngq	175	69	γ	γ	NN
cord-018572-e2qq4ngq	175	70	recruitment	recruitment	NN
cord-018572-e2qq4ngq	175	71	site	site	NN
cord-018572-e2qq4ngq	175	72	(	(	-LRB-
cord-018572-e2qq4ngq	175	73	Ren	Ren	NNP
cord-018572-e2qq4ngq	175	74	et	et	NNP
cord-018572-e2qq4ngq	175	75	al	al	NNP
cord-018572-e2qq4ngq	175	76	.	.	NNP
cord-018572-e2qq4ngq	175	77	2013	2013	CD
cord-018572-e2qq4ngq	175	78	)	)	-RRB-
cord-018572-e2qq4ngq	175	79	.	.	.
cord-018572-e2qq4ngq	176	1	Given	give	VBN
cord-018572-e2qq4ngq	176	2	the	the	DT
cord-018572-e2qq4ngq	176	3	structural	structural	JJ
cord-018572-e2qq4ngq	176	4	similarities	similarity	NNS
cord-018572-e2qq4ngq	176	5	,	,	,
cord-018572-e2qq4ngq	176	6	this	this	DT
cord-018572-e2qq4ngq	176	7	model	model	NN
cord-018572-e2qq4ngq	176	8	will	will	MD
cord-018572-e2qq4ngq	176	9	likely	likely	RB
cord-018572-e2qq4ngq	176	10	apply	apply	VB
cord-018572-e2qq4ngq	176	11	to	to	IN
cord-018572-e2qq4ngq	176	12	other	other	JJ
cord-018572-e2qq4ngq	176	13	Arf1-GTPcoat	Arf1-GTPcoat	NNP
cord-018572-e2qq4ngq	176	14	complexes	complex	NNS
cord-018572-e2qq4ngq	176	15	,	,	,
cord-018572-e2qq4ngq	176	16	including	include	VBG
cord-018572-e2qq4ngq	176	17	COPI	COPI	NNP
cord-018572-e2qq4ngq	176	18	.	.	.
cord-018572-e2qq4ngq	177	1	The	the	DT
cord-018572-e2qq4ngq	177	2	majority	majority	NN
cord-018572-e2qq4ngq	177	3	of	of	IN
cord-018572-e2qq4ngq	177	4	initial	initial	JJ
cord-018572-e2qq4ngq	177	5	studies	study	NNS
cord-018572-e2qq4ngq	177	6	on	on	IN
cord-018572-e2qq4ngq	177	7	the	the	DT
cord-018572-e2qq4ngq	177	8	Arf	Arf	NNP
cord-018572-e2qq4ngq	177	9	proteins	protein	NNS
cord-018572-e2qq4ngq	177	10	focused	focus	VBN
cord-018572-e2qq4ngq	177	11	mainly	mainly	RB
cord-018572-e2qq4ngq	177	12	on	on	IN
cord-018572-e2qq4ngq	177	13	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	177	14	at	at	IN
cord-018572-e2qq4ngq	177	15	the	the	DT
cord-018572-e2qq4ngq	177	16	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	177	17	and	and	CC
cord-018572-e2qq4ngq	177	18	Arf6	arf6	VB
cord-018572-e2qq4ngq	177	19	at	at	IN
cord-018572-e2qq4ngq	177	20	the	the	DT
cord-018572-e2qq4ngq	177	21	cell	cell	NN
cord-018572-e2qq4ngq	177	22	periphery	periphery	NN
cord-018572-e2qq4ngq	177	23	(	(	-LRB-
cord-018572-e2qq4ngq	177	24	D'Souza	D'Souza	NNP
cord-018572-e2qq4ngq	177	25	-	-	HYPH
cord-018572-e2qq4ngq	177	26	Schorey	Schorey	NNP
cord-018572-e2qq4ngq	177	27	and	and	CC
cord-018572-e2qq4ngq	177	28	Chavrier	Chavrier	NNP
cord-018572-e2qq4ngq	177	29	2006	2006	CD
cord-018572-e2qq4ngq	177	30	;	;	:
cord-018572-e2qq4ngq	177	31	Donaldson	Donaldson	NNP
cord-018572-e2qq4ngq	177	32	and	and	CC
cord-018572-e2qq4ngq	177	33	Jackson	Jackson	NNP
cord-018572-e2qq4ngq	177	34	2011	2011	CD
cord-018572-e2qq4ngq	177	35	)	)	-RRB-
cord-018572-e2qq4ngq	177	36	.	.	.
cord-018572-e2qq4ngq	178	1	This	this	DT
cord-018572-e2qq4ngq	178	2	exclusivity	exclusivity	NN
cord-018572-e2qq4ngq	178	3	was	be	VBD
cord-018572-e2qq4ngq	178	4	warranted	warrant	VBN
cord-018572-e2qq4ngq	178	5	,	,	,
cord-018572-e2qq4ngq	178	6	as	as	IN
cord-018572-e2qq4ngq	178	7	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	178	8	is	be	VBZ
cord-018572-e2qq4ngq	178	9	the	the	DT
cord-018572-e2qq4ngq	178	10	most	most	RBS
cord-018572-e2qq4ngq	178	11	highly	highly	RB
cord-018572-e2qq4ngq	178	12	expressed	express	VBN
cord-018572-e2qq4ngq	178	13	of	of	IN
cord-018572-e2qq4ngq	178	14	the	the	DT
cord-018572-e2qq4ngq	178	15	Arf	Arf	NNP
cord-018572-e2qq4ngq	178	16	proteins	protein	NNS
cord-018572-e2qq4ngq	178	17	in	in	IN
cord-018572-e2qq4ngq	178	18	cells	cell	NNS
cord-018572-e2qq4ngq	178	19	,	,	,
cord-018572-e2qq4ngq	178	20	and	and	CC
cord-018572-e2qq4ngq	178	21	is	be	VBZ
cord-018572-e2qq4ngq	178	22	essential	essential	JJ
cord-018572-e2qq4ngq	178	23	for	for	IN
cord-018572-e2qq4ngq	178	24	viability	viability	NN
cord-018572-e2qq4ngq	178	25	both	both	CC
cord-018572-e2qq4ngq	178	26	in	in	IN
cord-018572-e2qq4ngq	178	27	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	178	28	cells	cell	NNS
cord-018572-e2qq4ngq	178	29	(	(	-LRB-
cord-018572-e2qq4ngq	178	30	Reiling	Reiling	NNP
cord-018572-e2qq4ngq	178	31	et	et	FW
cord-018572-e2qq4ngq	178	32	al	al	NNP
cord-018572-e2qq4ngq	178	33	.	.	NNP
cord-018572-e2qq4ngq	178	34	2013	2013	CD
cord-018572-e2qq4ngq	178	35	)	)	-RRB-
cord-018572-e2qq4ngq	178	36	and	and	CC
cord-018572-e2qq4ngq	178	37	in	in	IN
cord-018572-e2qq4ngq	178	38	budding	bud	VBG
cord-018572-e2qq4ngq	178	39	yeast	yeast	NN
cord-018572-e2qq4ngq	178	40	,	,	,
cord-018572-e2qq4ngq	178	41	S.	S.	NNP
cord-018572-e2qq4ngq	178	42	cerevisiae	cerevisiae	NNS
cord-018572-e2qq4ngq	178	43	(	(	-LRB-
cord-018572-e2qq4ngq	178	44	Stearns	Stearns	NNP
cord-018572-e2qq4ngq	178	45	et	et	NNP
cord-018572-e2qq4ngq	178	46	al	al	NNP
cord-018572-e2qq4ngq	178	47	.	.	NNP
cord-018572-e2qq4ngq	178	48	1990a	1990a	CD
cord-018572-e2qq4ngq	178	49	)	)	-RRB-
cord-018572-e2qq4ngq	178	50	.	.	.
cord-018572-e2qq4ngq	179	1	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	179	2	has	have	VBZ
cord-018572-e2qq4ngq	179	3	functions	function	NNS
cord-018572-e2qq4ngq	179	4	at	at	IN
cord-018572-e2qq4ngq	179	5	the	the	DT
cord-018572-e2qq4ngq	179	6	cell	cell	NN
cord-018572-e2qq4ngq	179	7	periphery	periphery	NN
cord-018572-e2qq4ngq	179	8	in	in	IN
cord-018572-e2qq4ngq	179	9	cell	cell	NN
cord-018572-e2qq4ngq	179	10	adhesion	adhesion	NN
cord-018572-e2qq4ngq	179	11	and	and	CC
cord-018572-e2qq4ngq	179	12	motility	motility	NN
cord-018572-e2qq4ngq	179	13	that	that	WDT
cord-018572-e2qq4ngq	179	14	are	be	VBP
cord-018572-e2qq4ngq	179	15	involved	involve	VBN
cord-018572-e2qq4ngq	179	16	in	in	IN
cord-018572-e2qq4ngq	179	17	numerous	numerous	JJ
cord-018572-e2qq4ngq	179	18	human	human	JJ
cord-018572-e2qq4ngq	179	19	pathologies	pathology	NNS
cord-018572-e2qq4ngq	179	20	such	such	JJ
cord-018572-e2qq4ngq	179	21	as	as	IN
cord-018572-e2qq4ngq	179	22	cancer	cancer	NN
cord-018572-e2qq4ngq	179	23	,	,	,
cord-018572-e2qq4ngq	179	24	and	and	CC
cord-018572-e2qq4ngq	179	25	is	be	VBZ
cord-018572-e2qq4ngq	179	26	the	the	DT
cord-018572-e2qq4ngq	179	27	only	only	JJ
cord-018572-e2qq4ngq	179	28	member	member	NN
cord-018572-e2qq4ngq	179	29	of	of	IN
cord-018572-e2qq4ngq	179	30	the	the	DT
cord-018572-e2qq4ngq	179	31	class	class	NN
cord-018572-e2qq4ngq	179	32	III	iii	CD
cord-018572-e2qq4ngq	179	33	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	179	34	in	in	IN
cord-018572-e2qq4ngq	179	35	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	179	36	cells	cell	NNS
cord-018572-e2qq4ngq	179	37	.	.	.
cord-018572-e2qq4ngq	180	1	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	180	2	,	,	,
cord-018572-e2qq4ngq	180	3	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	180	4	,	,	,
cord-018572-e2qq4ngq	180	5	and	and	CC
cord-018572-e2qq4ngq	180	6	Arf5	Arf5	NNP
cord-018572-e2qq4ngq	180	7	,	,	,
cord-018572-e2qq4ngq	180	8	similarly	similarly	RB
cord-018572-e2qq4ngq	180	9	to	to	IN
cord-018572-e2qq4ngq	180	10	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	180	11	,	,	,
cord-018572-e2qq4ngq	180	12	all	all	DT
cord-018572-e2qq4ngq	180	13	localize	localize	VB
cord-018572-e2qq4ngq	180	14	to	to	IN
cord-018572-e2qq4ngq	180	15	internal	internal	JJ
cord-018572-e2qq4ngq	180	16	membranes	membrane	NNS
cord-018572-e2qq4ngq	180	17	,	,	,
cord-018572-e2qq4ngq	180	18	including	include	VBG
cord-018572-e2qq4ngq	180	19	the	the	DT
cord-018572-e2qq4ngq	180	20	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	180	21	.	.	.
cord-018572-e2qq4ngq	181	1	As	as	IN
cord-018572-e2qq4ngq	181	2	described	describe	VBN
cord-018572-e2qq4ngq	181	3	above	above	RB
cord-018572-e2qq4ngq	181	4	,	,	,
cord-018572-e2qq4ngq	181	5	phylogenetic	phylogenetic	JJ
cord-018572-e2qq4ngq	181	6	studies	study	NNS
cord-018572-e2qq4ngq	181	7	support	support	VBP
cord-018572-e2qq4ngq	181	8	the	the	DT
cord-018572-e2qq4ngq	181	9	conclusion	conclusion	NN
cord-018572-e2qq4ngq	181	10	that	that	IN
cord-018572-e2qq4ngq	181	11	these	these	DT
cord-018572-e2qq4ngq	181	12	other	other	JJ
cord-018572-e2qq4ngq	181	13	Class	class	NN
cord-018572-e2qq4ngq	181	14	I	i	NN
cord-018572-e2qq4ngq	181	15	and	and	CC
cord-018572-e2qq4ngq	181	16	II	II	NNP
cord-018572-e2qq4ngq	181	17	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	181	18	arose	arise	VBD
cord-018572-e2qq4ngq	181	19	late	late	RB
cord-018572-e2qq4ngq	181	20	in	in	IN
cord-018572-e2qq4ngq	181	21	animal	animal	NN
cord-018572-e2qq4ngq	181	22	cell	cell	NN
cord-018572-e2qq4ngq	181	23	evolution	evolution	NN
cord-018572-e2qq4ngq	181	24	,	,	,
cord-018572-e2qq4ngq	181	25	so	so	RB
cord-018572-e2qq4ngq	181	26	may	may	MD
cord-018572-e2qq4ngq	181	27	be	be	VB
cord-018572-e2qq4ngq	181	28	involved	involve	VBN
cord-018572-e2qq4ngq	181	29	in	in	IN
cord-018572-e2qq4ngq	181	30	more	more	RBR
cord-018572-e2qq4ngq	181	31	specialized	specialized	JJ
cord-018572-e2qq4ngq	181	32	functions	function	NNS
cord-018572-e2qq4ngq	181	33	,	,	,
cord-018572-e2qq4ngq	181	34	or	or	CC
cord-018572-e2qq4ngq	181	35	in	in	IN
cord-018572-e2qq4ngq	181	36	increasing	increase	VBG
cord-018572-e2qq4ngq	181	37	the	the	DT
cord-018572-e2qq4ngq	181	38	spatial	spatial	JJ
cord-018572-e2qq4ngq	181	39	or	or	CC
cord-018572-e2qq4ngq	181	40	temporal	temporal	JJ
cord-018572-e2qq4ngq	181	41	resolution	resolution	NN
cord-018572-e2qq4ngq	181	42	of	of	IN
cord-018572-e2qq4ngq	181	43	Arf1-mediated	arf1-mediated	JJ
cord-018572-e2qq4ngq	181	44	processes	process	NNS
cord-018572-e2qq4ngq	182	1	(	(	-LRB-
cord-018572-e2qq4ngq	182	2	Manolea	Manolea	NNP
cord-018572-e2qq4ngq	182	3	et	et	NNP
cord-018572-e2qq4ngq	182	4	al	al	NNP
cord-018572-e2qq4ngq	182	5	.	.	NNP
cord-018572-e2qq4ngq	182	6	2010	2010	CD
cord-018572-e2qq4ngq	182	7	)	)	-RRB-
cord-018572-e2qq4ngq	182	8	.	.	.
cord-018572-e2qq4ngq	183	1	Interestingly	interestingly	RB
cord-018572-e2qq4ngq	183	2	,	,	,
cord-018572-e2qq4ngq	183	3	partial	partial	JJ
cord-018572-e2qq4ngq	183	4	depletion	depletion	NN
cord-018572-e2qq4ngq	183	5	experiments	experiment	NNS
cord-018572-e2qq4ngq	183	6	show	show	VBP
cord-018572-e2qq4ngq	183	7	that	that	IN
cord-018572-e2qq4ngq	183	8	under	under	IN
cord-018572-e2qq4ngq	183	9	conditions	condition	NNS
cord-018572-e2qq4ngq	183	10	where	where	WRB
cord-018572-e2qq4ngq	183	11	single	single	JJ
cord-018572-e2qq4ngq	183	12	knockdowns	knockdown	NNS
cord-018572-e2qq4ngq	183	13	have	have	VBP
cord-018572-e2qq4ngq	183	14	little	little	JJ
cord-018572-e2qq4ngq	183	15	if	if	IN
cord-018572-e2qq4ngq	183	16	any	any	DT
cord-018572-e2qq4ngq	183	17	phenotypic	phenotypic	JJ
cord-018572-e2qq4ngq	183	18	effects	effect	NNS
cord-018572-e2qq4ngq	183	19	,	,	,
cord-018572-e2qq4ngq	183	20	siRNA	siRNA	NNP
cord-018572-e2qq4ngq	183	21	depletion	depletion	NN
cord-018572-e2qq4ngq	183	22	of	of	IN
cord-018572-e2qq4ngq	183	23	pairs	pair	NNS
cord-018572-e2qq4ngq	183	24	of	of	IN
cord-018572-e2qq4ngq	183	25	Arf1-Arf5	Arf1-Arf5	NNP
cord-018572-e2qq4ngq	183	26	has	have	VBZ
cord-018572-e2qq4ngq	183	27	effects	effect	NNS
cord-018572-e2qq4ngq	183	28	on	on	IN
cord-018572-e2qq4ngq	183	29	specific	specific	JJ
cord-018572-e2qq4ngq	183	30	membrane	membrane	NN
cord-018572-e2qq4ngq	183	31	trafficking	trafficking	NN
cord-018572-e2qq4ngq	183	32	steps	step	NNS
cord-018572-e2qq4ngq	183	33	(	(	-LRB-
cord-018572-e2qq4ngq	183	34	Volpicelli	Volpicelli	NNP
cord-018572-e2qq4ngq	183	35	-	-	HYPH
cord-018572-e2qq4ngq	183	36	Daley	Daley	NNP
cord-018572-e2qq4ngq	183	37	et	et	NNP
cord-018572-e2qq4ngq	183	38	al	al	NNP
cord-018572-e2qq4ngq	183	39	.	.	NNP
cord-018572-e2qq4ngq	183	40	2005	2005	CD
cord-018572-e2qq4ngq	183	41	)	)	-RRB-
cord-018572-e2qq4ngq	183	42	.	.	.
cord-018572-e2qq4ngq	184	1	For	for	IN
cord-018572-e2qq4ngq	184	2	example	example	NN
cord-018572-e2qq4ngq	184	3	,	,	,
cord-018572-e2qq4ngq	184	4	the	the	DT
cord-018572-e2qq4ngq	184	5	double	double	JJ
cord-018572-e2qq4ngq	184	6	knockdown	knockdown	NN
cord-018572-e2qq4ngq	184	7	of	of	IN
cord-018572-e2qq4ngq	184	8	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	184	9	and	and	CC
cord-018572-e2qq4ngq	184	10	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	184	11	affects	affect	VBZ
cord-018572-e2qq4ngq	184	12	transport	transport	NN
cord-018572-e2qq4ngq	184	13	in	in	IN
cord-018572-e2qq4ngq	184	14	the	the	DT
cord-018572-e2qq4ngq	184	15	early	early	JJ
cord-018572-e2qq4ngq	184	16	secretory	secretory	JJ
cord-018572-e2qq4ngq	184	17	pathway	pathway	NN
cord-018572-e2qq4ngq	184	18	,	,	,
cord-018572-e2qq4ngq	184	19	inhibiting	inhibit	VBG
cord-018572-e2qq4ngq	184	20	COPI	COPI	NNP
cord-018572-e2qq4ngq	184	21	coat	coat	NN
cord-018572-e2qq4ngq	184	22	recruitment	recruitment	NN
cord-018572-e2qq4ngq	184	23	,	,	,
cord-018572-e2qq4ngq	184	24	but	but	CC
cord-018572-e2qq4ngq	184	25	has	have	VBZ
cord-018572-e2qq4ngq	184	26	little	little	JJ
cord-018572-e2qq4ngq	184	27	effect	effect	NN
cord-018572-e2qq4ngq	184	28	on	on	IN
cord-018572-e2qq4ngq	184	29	several	several	JJ
cord-018572-e2qq4ngq	184	30	other	other	JJ
cord-018572-e2qq4ngq	184	31	trafficking	traffic	VBG
cord-018572-e2qq4ngq	184	32	pathways	pathway	NNS
cord-018572-e2qq4ngq	184	33	(	(	-LRB-
cord-018572-e2qq4ngq	184	34	Volpicelli	Volpicelli	NNP
cord-018572-e2qq4ngq	184	35	-	-	HYPH
cord-018572-e2qq4ngq	184	36	Daley	Daley	NNP
cord-018572-e2qq4ngq	184	37	et	et	NNP
cord-018572-e2qq4ngq	184	38	al	al	NNP
cord-018572-e2qq4ngq	184	39	.	.	NNP
cord-018572-e2qq4ngq	184	40	2005	2005	CD
cord-018572-e2qq4ngq	184	41	)	)	-RRB-
cord-018572-e2qq4ngq	184	42	.	.	.
cord-018572-e2qq4ngq	185	1	Consistent	consistent	JJ
cord-018572-e2qq4ngq	185	2	with	with	IN
cord-018572-e2qq4ngq	185	3	this	this	DT
cord-018572-e2qq4ngq	185	4	observation	observation	NN
cord-018572-e2qq4ngq	185	5	,	,	,
cord-018572-e2qq4ngq	185	6	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	185	7	localizes	localize	VBZ
cord-018572-e2qq4ngq	185	8	to	to	IN
cord-018572-e2qq4ngq	185	9	the	the	DT
cord-018572-e2qq4ngq	185	10	ERGIC	ERGIC	NNP
cord-018572-e2qq4ngq	185	11	and	and	CC
cord-018572-e2qq4ngq	185	12	cis	cis	NNP
cord-018572-e2qq4ngq	185	13	-	-	HYPH
cord-018572-e2qq4ngq	185	14	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	185	15	,	,	,
cord-018572-e2qq4ngq	185	16	and	and	CC
cord-018572-e2qq4ngq	185	17	together	together	RB
cord-018572-e2qq4ngq	185	18	with	with	IN
cord-018572-e2qq4ngq	185	19	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	185	20	at	at	IN
cord-018572-e2qq4ngq	185	21	the	the	DT
cord-018572-e2qq4ngq	185	22	cis	cis	NNP
cord-018572-e2qq4ngq	185	23	-	-	HYPH
cord-018572-e2qq4ngq	185	24	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	185	25	,	,	,
cord-018572-e2qq4ngq	185	26	it	-PRON-	PRP
cord-018572-e2qq4ngq	185	27	organizes	organize	VBZ
cord-018572-e2qq4ngq	185	28	trafficking	traffic	VBG
cord-018572-e2qq4ngq	185	29	between	between	IN
cord-018572-e2qq4ngq	185	30	these	these	DT
cord-018572-e2qq4ngq	185	31	compartments	compartment	NNS
cord-018572-e2qq4ngq	186	1	(	(	-LRB-
cord-018572-e2qq4ngq	186	2	Ben	Ben	NNP
cord-018572-e2qq4ngq	186	3	-	-	HYPH
cord-018572-e2qq4ngq	186	4	Tekaya	Tekaya	NNP
cord-018572-e2qq4ngq	186	5	et	et	NNP
cord-018572-e2qq4ngq	186	6	al	al	NNP
cord-018572-e2qq4ngq	186	7	.	.	NNP
cord-018572-e2qq4ngq	186	8	2010	2010	CD
cord-018572-e2qq4ngq	186	9	)	)	-RRB-
cord-018572-e2qq4ngq	186	10	.	.	.
cord-018572-e2qq4ngq	187	1	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	187	2	and	and	CC
cord-018572-e2qq4ngq	187	3	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	187	4	differ	differ	VBP
cord-018572-e2qq4ngq	187	5	only	only	RB
cord-018572-e2qq4ngq	187	6	at	at	IN
cord-018572-e2qq4ngq	187	7	seven	seven	CD
cord-018572-e2qq4ngq	187	8	amino	amino	NN
cord-018572-e2qq4ngq	187	9	acid	acid	NN
cord-018572-e2qq4ngq	187	10	positions	position	NNS
cord-018572-e2qq4ngq	187	11	in	in	IN
cord-018572-e2qq4ngq	187	12	their	-PRON-	PRP$
cord-018572-e2qq4ngq	187	13	amino	amino	NN
cord-018572-e2qq4ngq	187	14	-	-	HYPH
cord-018572-e2qq4ngq	187	15	and	and	CC
cord-018572-e2qq4ngq	187	16	carboxy	carboxy	JJ
cord-018572-e2qq4ngq	187	17	-	-	HYPH
cord-018572-e2qq4ngq	187	18	terminal	terminal	NN
cord-018572-e2qq4ngq	187	19	regions	region	NNS
cord-018572-e2qq4ngq	187	20	and	and	CC
cord-018572-e2qq4ngq	187	21	previously	previously	RB
cord-018572-e2qq4ngq	187	22	they	-PRON-	PRP
cord-018572-e2qq4ngq	187	23	were	be	VBD
cord-018572-e2qq4ngq	187	24	thought	think	VBN
cord-018572-e2qq4ngq	187	25	to	to	TO
cord-018572-e2qq4ngq	187	26	function	function	VB
cord-018572-e2qq4ngq	187	27	and	and	CC
cord-018572-e2qq4ngq	187	28	localize	localize	VB
cord-018572-e2qq4ngq	187	29	identically	identically	RB
cord-018572-e2qq4ngq	187	30	in	in	IN
cord-018572-e2qq4ngq	187	31	cells	cell	NNS
cord-018572-e2qq4ngq	187	32	.	.	.
cord-018572-e2qq4ngq	188	1	However	however	RB
cord-018572-e2qq4ngq	188	2	,	,	,
cord-018572-e2qq4ngq	188	3	a	a	DT
cord-018572-e2qq4ngq	188	4	Golgi	golgi	NN
cord-018572-e2qq4ngq	188	5	-	-	HYPH
cord-018572-e2qq4ngq	188	6	targeting	target	VBG
cord-018572-e2qq4ngq	188	7	sequence	sequence	NN
cord-018572-e2qq4ngq	188	8	contained	contain	VBN
cord-018572-e2qq4ngq	188	9	within	within	IN
cord-018572-e2qq4ngq	188	10	the	the	DT
cord-018572-e2qq4ngq	188	11	α-3	α-3	DT
cord-018572-e2qq4ngq	188	12	helix	helix	NN
cord-018572-e2qq4ngq	188	13	of	of	IN
cord-018572-e2qq4ngq	188	14	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	188	15	and	and	CC
cord-018572-e2qq4ngq	188	16	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	188	17	targets	target	VBZ
cord-018572-e2qq4ngq	188	18	a	a	DT
cord-018572-e2qq4ngq	188	19	chimaera	chimaera	NN
cord-018572-e2qq4ngq	188	20	between	between	IN
cord-018572-e2qq4ngq	188	21	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	188	22	and	and	CC
cord-018572-e2qq4ngq	188	23	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	188	24	to	to	IN
cord-018572-e2qq4ngq	188	25	the	the	DT
cord-018572-e2qq4ngq	188	26	early	early	JJ
cord-018572-e2qq4ngq	188	27	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	188	28	(	(	-LRB-
cord-018572-e2qq4ngq	188	29	Honda	Honda	NNP
cord-018572-e2qq4ngq	188	30	et	et	NNP
cord-018572-e2qq4ngq	188	31	al	al	NNP
cord-018572-e2qq4ngq	188	32	.	.	NNP
cord-018572-e2qq4ngq	188	33	2005	2005	CD
cord-018572-e2qq4ngq	188	34	)	)	-RRB-
cord-018572-e2qq4ngq	188	35	.	.	.
cord-018572-e2qq4ngq	189	1	Furthermore	furthermore	RB
cord-018572-e2qq4ngq	189	2	,	,	,
cord-018572-e2qq4ngq	189	3	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	189	4	localizes	localize	VBZ
cord-018572-e2qq4ngq	189	5	specifically	specifically	RB
cord-018572-e2qq4ngq	189	6	to	to	IN
cord-018572-e2qq4ngq	189	7	the	the	DT
cord-018572-e2qq4ngq	189	8	trans	trans	NNP
cord-018572-e2qq4ngq	189	9	-	-	NNP
cord-018572-e2qq4ngq	189	10	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	189	11	and	and	CC
cord-018572-e2qq4ngq	189	12	TGN	TGN	NNP
cord-018572-e2qq4ngq	189	13	and	and	CC
cord-018572-e2qq4ngq	189	14	this	this	DT
cord-018572-e2qq4ngq	189	15	localization	localization	NN
cord-018572-e2qq4ngq	189	16	depends	depend	VBZ
cord-018572-e2qq4ngq	189	17	on	on	IN
cord-018572-e2qq4ngq	189	18	four	four	CD
cord-018572-e2qq4ngq	189	19	Arf3-specific	arf3-specific	NN
cord-018572-e2qq4ngq	189	20	amino	amino	NN
cord-018572-e2qq4ngq	189	21	acids	acid	NNS
cord-018572-e2qq4ngq	189	22	contained	contain	VBN
cord-018572-e2qq4ngq	189	23	in	in	IN
cord-018572-e2qq4ngq	189	24	the	the	DT
cord-018572-e2qq4ngq	189	25	N	n	CD
cord-018572-e2qq4ngq	189	26	-	-	HYPH
cord-018572-e2qq4ngq	189	27	terminal	terminal	NN
cord-018572-e2qq4ngq	189	28	amphipathic	amphipathic	NNP
cord-018572-e2qq4ngq	189	29	helix	helix	NNP
cord-018572-e2qq4ngq	189	30	,	,	,
cord-018572-e2qq4ngq	189	31	which	which	WDT
cord-018572-e2qq4ngq	189	32	are	be	VBP
cord-018572-e2qq4ngq	189	33	conserved	conserve	VBN
cord-018572-e2qq4ngq	189	34	among	among	IN
cord-018572-e2qq4ngq	189	35	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	189	36	homologues	homologue	NNS
cord-018572-e2qq4ngq	189	37	(	(	-LRB-
cord-018572-e2qq4ngq	189	38	Manolea	Manolea	NNP
cord-018572-e2qq4ngq	189	39	et	et	NNP
cord-018572-e2qq4ngq	189	40	al	al	NNP
cord-018572-e2qq4ngq	189	41	.	.	NNP
cord-018572-e2qq4ngq	189	42	2010	2010	CD
cord-018572-e2qq4ngq	189	43	)	)	-RRB-
cord-018572-e2qq4ngq	189	44	(	(	-LRB-
cord-018572-e2qq4ngq	189	45	Fig	Fig	NNP
cord-018572-e2qq4ngq	189	46	.	.	.
cord-018572-e2qq4ngq	189	47	8.1b	8.1b	CD
cord-018572-e2qq4ngq	189	48	)	)	-RRB-
cord-018572-e2qq4ngq	189	49	.	.	.
cord-018572-e2qq4ngq	190	1	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	190	2	,	,	,
cord-018572-e2qq4ngq	190	3	but	but	CC
cord-018572-e2qq4ngq	190	4	not	not	RB
cord-018572-e2qq4ngq	190	5	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	190	6	,	,	,
cord-018572-e2qq4ngq	190	7	becomes	become	VBZ
cord-018572-e2qq4ngq	190	8	cytosolic	cytosolic	JJ
cord-018572-e2qq4ngq	190	9	at	at	IN
cord-018572-e2qq4ngq	190	10	20	20	CD
cord-018572-e2qq4ngq	190	11	C	c	NN
cord-018572-e2qq4ngq	190	12	,	,	,
cord-018572-e2qq4ngq	190	13	the	the	DT
cord-018572-e2qq4ngq	190	14	temperature	temperature	NN
cord-018572-e2qq4ngq	190	15	at	at	IN
cord-018572-e2qq4ngq	190	16	which	which	WDT
cord-018572-e2qq4ngq	190	17	exit	exit	NN
cord-018572-e2qq4ngq	190	18	from	from	IN
cord-018572-e2qq4ngq	190	19	the	the	DT
cord-018572-e2qq4ngq	190	20	TGN	TGN	NNP
cord-018572-e2qq4ngq	190	21	is	be	VBZ
cord-018572-e2qq4ngq	190	22	blocked	block	VBN
cord-018572-e2qq4ngq	190	23	(	(	-LRB-
cord-018572-e2qq4ngq	190	24	Manolea	Manolea	NNP
cord-018572-e2qq4ngq	190	25	et	et	NNP
cord-018572-e2qq4ngq	190	26	al	al	NNP
cord-018572-e2qq4ngq	190	27	.	.	NNP
cord-018572-e2qq4ngq	190	28	2010	2010	CD
cord-018572-e2qq4ngq	190	29	)	)	-RRB-
cord-018572-e2qq4ngq	190	30	.	.	.
cord-018572-e2qq4ngq	191	1	These	these	DT
cord-018572-e2qq4ngq	191	2	results	result	NNS
cord-018572-e2qq4ngq	191	3	support	support	VBP
cord-018572-e2qq4ngq	191	4	the	the	DT
cord-018572-e2qq4ngq	191	5	conclusion	conclusion	NN
cord-018572-e2qq4ngq	191	6	that	that	IN
cord-018572-e2qq4ngq	191	7	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	191	8	has	have	VBZ
cord-018572-e2qq4ngq	191	9	a	a	DT
cord-018572-e2qq4ngq	191	10	critical	critical	JJ
cord-018572-e2qq4ngq	191	11	role	role	NN
cord-018572-e2qq4ngq	191	12	during	during	IN
cord-018572-e2qq4ngq	191	13	exit	exit	NN
cord-018572-e2qq4ngq	191	14	from	from	IN
cord-018572-e2qq4ngq	191	15	the	the	DT
cord-018572-e2qq4ngq	191	16	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	191	17	.	.	.
cord-018572-e2qq4ngq	192	1	Recently	recently	RB
cord-018572-e2qq4ngq	192	2	,	,	,
cord-018572-e2qq4ngq	192	3	Class	Class	NNP
cord-018572-e2qq4ngq	192	4	II	II	NNP
cord-018572-e2qq4ngq	192	5	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	192	6	have	have	VBP
cord-018572-e2qq4ngq	192	7	been	be	VBN
cord-018572-e2qq4ngq	192	8	shown	show	VBN
cord-018572-e2qq4ngq	192	9	to	to	TO
cord-018572-e2qq4ngq	192	10	participate	participate	VB
cord-018572-e2qq4ngq	192	11	in	in	IN
cord-018572-e2qq4ngq	192	12	novel	novel	JJ
cord-018572-e2qq4ngq	192	13	functions	function	NNS
cord-018572-e2qq4ngq	192	14	at	at	IN
cord-018572-e2qq4ngq	192	15	the	the	DT
cord-018572-e2qq4ngq	192	16	TGN	TGN	NNP
cord-018572-e2qq4ngq	192	17	.	.	.
cord-018572-e2qq4ngq	193	1	D.	D.	NNP
cord-018572-e2qq4ngq	193	2	Deretic	Deretic	NNP
cord-018572-e2qq4ngq	193	3	and	and	CC
cord-018572-e2qq4ngq	193	4	colleagues	colleague	NNS
cord-018572-e2qq4ngq	193	5	have	have	VBP
cord-018572-e2qq4ngq	193	6	found	find	VBN
cord-018572-e2qq4ngq	193	7	that	that	IN
cord-018572-e2qq4ngq	193	8	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	193	9	specifically	specifically	RB
cord-018572-e2qq4ngq	193	10	recognizes	recognize	VBZ
cord-018572-e2qq4ngq	193	11	the	the	DT
cord-018572-e2qq4ngq	193	12	VxPx	VxPx	NNP
cord-018572-e2qq4ngq	193	13	cytosolic	cytosolic	JJ
cord-018572-e2qq4ngq	193	14	targeting	target	VBG
cord-018572-e2qq4ngq	193	15	motif	motif	NN
cord-018572-e2qq4ngq	193	16	in	in	IN
cord-018572-e2qq4ngq	193	17	retinal	retinal	JJ
cord-018572-e2qq4ngq	193	18	rhodopsin	rhodopsin	NN
cord-018572-e2qq4ngq	193	19	to	to	TO
cord-018572-e2qq4ngq	193	20	facilitate	facilitate	VB
cord-018572-e2qq4ngq	193	21	its	-PRON-	PRP$
cord-018572-e2qq4ngq	193	22	transport	transport	NN
cord-018572-e2qq4ngq	193	23	into	into	IN
cord-018572-e2qq4ngq	193	24	the	the	DT
cord-018572-e2qq4ngq	193	25	rod	rod	NN
cord-018572-e2qq4ngq	193	26	outer	outer	JJ
cord-018572-e2qq4ngq	193	27	segment	segment	NN
cord-018572-e2qq4ngq	193	28	,	,	,
cord-018572-e2qq4ngq	193	29	a	a	DT
cord-018572-e2qq4ngq	193	30	specialized	specialized	JJ
cord-018572-e2qq4ngq	193	31	cilium	cilium	NN
cord-018572-e2qq4ngq	193	32	(	(	-LRB-
cord-018572-e2qq4ngq	193	33	Deretic	Deretic	NNP
cord-018572-e2qq4ngq	193	34	et	et	FW
cord-018572-e2qq4ngq	193	35	al	al	NNP
cord-018572-e2qq4ngq	193	36	.	.	NNP
cord-018572-e2qq4ngq	193	37	2005	2005	CD
cord-018572-e2qq4ngq	193	38	)	)	-RRB-
cord-018572-e2qq4ngq	193	39	.	.	.
cord-018572-e2qq4ngq	194	1	This	this	DT
cord-018572-e2qq4ngq	194	2	ciliary	ciliary	NN
cord-018572-e2qq4ngq	194	3	targeting	target	VBG
cord-018572-e2qq4ngq	194	4	complex	complex	NN
cord-018572-e2qq4ngq	194	5	includes	include	VBZ
cord-018572-e2qq4ngq	194	6	Rab11	Rab11	NNP
cord-018572-e2qq4ngq	194	7	,	,	,
cord-018572-e2qq4ngq	194	8	FIP3	FIP3	NNP
cord-018572-e2qq4ngq	194	9	(	(	-LRB-
cord-018572-e2qq4ngq	194	10	a	a	DT
cord-018572-e2qq4ngq	194	11	dual	dual	JJ
cord-018572-e2qq4ngq	194	12	Arf	Arf	NNP
cord-018572-e2qq4ngq	194	13	and	and	CC
cord-018572-e2qq4ngq	194	14	Rab11	Rab11	NNP
cord-018572-e2qq4ngq	194	15	effector	effector	NN
cord-018572-e2qq4ngq	194	16	)	)	-RRB-
cord-018572-e2qq4ngq	194	17	,	,	,
cord-018572-e2qq4ngq	194	18	and	and	CC
cord-018572-e2qq4ngq	194	19	ASAP1	asap1	NN
cord-018572-e2qq4ngq	194	20	,	,	,
cord-018572-e2qq4ngq	194	21	an	an	DT
cord-018572-e2qq4ngq	194	22	Arf	Arf	NNP
cord-018572-e2qq4ngq	194	23	GAP	GAP	NNP
cord-018572-e2qq4ngq	194	24	(	(	-LRB-
cord-018572-e2qq4ngq	194	25	Mazelova	Mazelova	NNP
cord-018572-e2qq4ngq	194	26	et	et	FW
cord-018572-e2qq4ngq	194	27	al	al	NNP
cord-018572-e2qq4ngq	194	28	.	.	.
cord-018572-e2qq4ngq	194	29	2009	2009	CD
cord-018572-e2qq4ngq	194	30	)	)	-RRB-
cord-018572-e2qq4ngq	194	31	,	,	,
cord-018572-e2qq4ngq	194	32	in	in	IN
cord-018572-e2qq4ngq	194	33	addition	addition	NN
cord-018572-e2qq4ngq	194	34	to	to	IN
cord-018572-e2qq4ngq	194	35	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	194	36	.	.	.
cord-018572-e2qq4ngq	195	1	The	the	DT
cord-018572-e2qq4ngq	195	2	mechanism	mechanism	NN
cord-018572-e2qq4ngq	195	3	by	by	IN
cord-018572-e2qq4ngq	195	4	which	which	WDT
cord-018572-e2qq4ngq	195	5	this	this	DT
cord-018572-e2qq4ngq	195	6	complex	complex	NN
cord-018572-e2qq4ngq	195	7	facilitates	facilitate	VBZ
cord-018572-e2qq4ngq	195	8	the	the	DT
cord-018572-e2qq4ngq	195	9	packaging	packaging	NN
cord-018572-e2qq4ngq	195	10	of	of	IN
cord-018572-e2qq4ngq	195	11	rhodopsin	rhodopsin	NN
cord-018572-e2qq4ngq	195	12	into	into	IN
cord-018572-e2qq4ngq	195	13	post	post	JJ
cord-018572-e2qq4ngq	195	14	-	-	JJ
cord-018572-e2qq4ngq	195	15	Golgi	golgi	JJ
cord-018572-e2qq4ngq	195	16	carriers	carrier	NNS
cord-018572-e2qq4ngq	195	17	has	have	VBZ
cord-018572-e2qq4ngq	195	18	not	not	RB
cord-018572-e2qq4ngq	195	19	yet	yet	RB
cord-018572-e2qq4ngq	195	20	been	be	VBN
cord-018572-e2qq4ngq	195	21	determined	determine	VBN
cord-018572-e2qq4ngq	195	22	,	,	,
cord-018572-e2qq4ngq	195	23	but	but	CC
cord-018572-e2qq4ngq	195	24	it	-PRON-	PRP
cord-018572-e2qq4ngq	195	25	is	be	VBZ
cord-018572-e2qq4ngq	195	26	known	know	VBN
cord-018572-e2qq4ngq	195	27	that	that	DT
cord-018572-e2qq4ngq	195	28	rhodopsin	rhodopsin	NN
cord-018572-e2qq4ngq	195	29	itself	-PRON-	PRP
cord-018572-e2qq4ngq	195	30	initiates	initiate	VBZ
cord-018572-e2qq4ngq	195	31	complex	complex	JJ
cord-018572-e2qq4ngq	195	32	formation	formation	NN
cord-018572-e2qq4ngq	195	33	by	by	IN
cord-018572-e2qq4ngq	195	34	recruiting	recruit	VBG
cord-018572-e2qq4ngq	195	35	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	195	36	.	.	.
cord-018572-e2qq4ngq	196	1	The	the	DT
cord-018572-e2qq4ngq	196	2	rhodopsin	rhodopsin	NN
cord-018572-e2qq4ngq	196	3	-	-	HYPH
cord-018572-e2qq4ngq	196	4	binding	bind	VBG
cord-018572-e2qq4ngq	196	5	site	site	NN
cord-018572-e2qq4ngq	196	6	of	of	IN
cord-018572-e2qq4ngq	196	7	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	196	8	has	have	VBZ
cord-018572-e2qq4ngq	196	9	been	be	VBN
cord-018572-e2qq4ngq	196	10	mapped	map	VBN
cord-018572-e2qq4ngq	196	11	to	to	IN
cord-018572-e2qq4ngq	196	12	the	the	DT
cord-018572-e2qq4ngq	196	13	α-3	α-3	NN
cord-018572-e2qq4ngq	196	14	helix	helix	NN
cord-018572-e2qq4ngq	196	15	(	(	-LRB-
cord-018572-e2qq4ngq	196	16	Deretic	Deretic	NNP
cord-018572-e2qq4ngq	196	17	et	et	FW
cord-018572-e2qq4ngq	196	18	al	al	NNP
cord-018572-e2qq4ngq	196	19	.	.	NNP
cord-018572-e2qq4ngq	196	20	2005	2005	CD
cord-018572-e2qq4ngq	196	21	)	)	-RRB-
cord-018572-e2qq4ngq	196	22	,	,	,
cord-018572-e2qq4ngq	196	23	which	which	WDT
cord-018572-e2qq4ngq	196	24	corresponds	correspond	VBZ
cord-018572-e2qq4ngq	196	25	to	to	IN
cord-018572-e2qq4ngq	196	26	the	the	DT
cord-018572-e2qq4ngq	196	27	region	region	NN
cord-018572-e2qq4ngq	196	28	of	of	IN
cord-018572-e2qq4ngq	196	29	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	196	30	that	that	WDT
cord-018572-e2qq4ngq	196	31	binds	bind	VBZ
cord-018572-e2qq4ngq	196	32	the	the	DT
cord-018572-e2qq4ngq	196	33	SNARE	snare	NN
cord-018572-e2qq4ngq	196	34	protein	protein	NN
cord-018572-e2qq4ngq	196	35	membrin	membrin	NNS
cord-018572-e2qq4ngq	196	36	to	to	TO
cord-018572-e2qq4ngq	196	37	mediate	mediate	VB
cord-018572-e2qq4ngq	196	38	targeting	target	VBG
cord-018572-e2qq4ngq	196	39	to	to	IN
cord-018572-e2qq4ngq	196	40	the	the	DT
cord-018572-e2qq4ngq	196	41	early	early	JJ
cord-018572-e2qq4ngq	196	42	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	196	43	(	(	-LRB-
cord-018572-e2qq4ngq	196	44	Honda	Honda	NNP
cord-018572-e2qq4ngq	196	45	et	et	NNP
cord-018572-e2qq4ngq	196	46	al	al	NNP
cord-018572-e2qq4ngq	196	47	.	.	NNP
cord-018572-e2qq4ngq	196	48	2005	2005	CD
cord-018572-e2qq4ngq	196	49	)	)	-RRB-
cord-018572-e2qq4ngq	196	50	.	.	.
cord-018572-e2qq4ngq	197	1	Hence	hence	RB
cord-018572-e2qq4ngq	197	2	,	,	,
cord-018572-e2qq4ngq	197	3	the	the	DT
cord-018572-e2qq4ngq	197	4	α-3	α-3	NN
cord-018572-e2qq4ngq	197	5	helix	helix	NN
cord-018572-e2qq4ngq	197	6	might	may	MD
cord-018572-e2qq4ngq	197	7	generally	generally	RB
cord-018572-e2qq4ngq	197	8	allow	allow	VB
cord-018572-e2qq4ngq	197	9	Arf	Arf	NNP
cord-018572-e2qq4ngq	197	10	protein	protein	NN
cord-018572-e2qq4ngq	197	11	binding	bind	VBG
cord-018572-e2qq4ngq	197	12	to	to	IN
cord-018572-e2qq4ngq	197	13	membrane	membrane	NN
cord-018572-e2qq4ngq	197	14	receptors	receptor	NNS
cord-018572-e2qq4ngq	197	15	.	.	.
cord-018572-e2qq4ngq	198	1	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	198	2	and	and	CC
cord-018572-e2qq4ngq	198	3	Arf5	Arf5	NNP
cord-018572-e2qq4ngq	198	4	can	can	MD
cord-018572-e2qq4ngq	198	5	also	also	RB
cord-018572-e2qq4ngq	198	6	directly	directly	RB
cord-018572-e2qq4ngq	198	7	bind	bind	VB
cord-018572-e2qq4ngq	198	8	to	to	IN
cord-018572-e2qq4ngq	198	9	the	the	DT
cord-018572-e2qq4ngq	198	10	calcium	calcium	NN
cord-018572-e2qq4ngq	198	11	-	-	HYPH
cord-018572-e2qq4ngq	198	12	dependent	dependent	JJ
cord-018572-e2qq4ngq	198	13	activator	activator	NN
cord-018572-e2qq4ngq	198	14	protein	protein	NN
cord-018572-e2qq4ngq	198	15	for	for	IN
cord-018572-e2qq4ngq	198	16	secretion	secretion	NN
cord-018572-e2qq4ngq	198	17	(	(	-LRB-
cord-018572-e2qq4ngq	198	18	CAPS	cap	NNS
cord-018572-e2qq4ngq	198	19	)	)	-RRB-
cord-018572-e2qq4ngq	198	20	,	,	,
cord-018572-e2qq4ngq	198	21	which	which	WDT
cord-018572-e2qq4ngq	198	22	regulates	regulate	VBZ
cord-018572-e2qq4ngq	198	23	exocytosis	exocytosis	NN
cord-018572-e2qq4ngq	198	24	of	of	IN
cord-018572-e2qq4ngq	198	25	dense	dense	JJ
cord-018572-e2qq4ngq	198	26	core	core	NN
cord-018572-e2qq4ngq	198	27	vesicles	vesicle	NNS
cord-018572-e2qq4ngq	198	28	from	from	IN
cord-018572-e2qq4ngq	198	29	nerve	nerve	NN
cord-018572-e2qq4ngq	198	30	terminals	terminal	NNS
cord-018572-e2qq4ngq	198	31	(	(	-LRB-
cord-018572-e2qq4ngq	198	32	Sadakata	Sadakata	NNP
cord-018572-e2qq4ngq	198	33	et	et	FW
cord-018572-e2qq4ngq	198	34	al	al	NNP
cord-018572-e2qq4ngq	198	35	.	.	NNP
cord-018572-e2qq4ngq	198	36	2010	2010	CD
cord-018572-e2qq4ngq	198	37	)	)	-RRB-
cord-018572-e2qq4ngq	198	38	.	.	.
cord-018572-e2qq4ngq	199	1	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	199	2	and	and	CC
cord-018572-e2qq4ngq	199	3	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	199	4	together	together	RB
cord-018572-e2qq4ngq	199	5	have	have	VBP
cord-018572-e2qq4ngq	199	6	been	be	VBN
cord-018572-e2qq4ngq	199	7	shown	show	VBN
cord-018572-e2qq4ngq	199	8	to	to	TO
cord-018572-e2qq4ngq	199	9	play	play	VB
cord-018572-e2qq4ngq	199	10	a	a	DT
cord-018572-e2qq4ngq	199	11	role	role	NN
cord-018572-e2qq4ngq	199	12	in	in	IN
cord-018572-e2qq4ngq	199	13	endosome	endosome	NN
cord-018572-e2qq4ngq	199	14	-	-	HYPH
cord-018572-e2qq4ngq	199	15	TGN	TGN	NNP
cord-018572-e2qq4ngq	199	16	trafficking	trafficking	NN
cord-018572-e2qq4ngq	199	17	;	;	:
cord-018572-e2qq4ngq	199	18	the	the	DT
cord-018572-e2qq4ngq	199	19	double	double	JJ
cord-018572-e2qq4ngq	199	20	knockdown	knockdown	NN
cord-018572-e2qq4ngq	199	21	causes	cause	VBZ
cord-018572-e2qq4ngq	199	22	tubulation	tubulation	NN
cord-018572-e2qq4ngq	199	23	of	of	IN
cord-018572-e2qq4ngq	199	24	the	the	DT
cord-018572-e2qq4ngq	199	25	recycling	recycling	NN
cord-018572-e2qq4ngq	199	26	endosome	endosome	NN
cord-018572-e2qq4ngq	199	27	and	and	CC
cord-018572-e2qq4ngq	199	28	an	an	DT
cord-018572-e2qq4ngq	199	29	inhibition	inhibition	NN
cord-018572-e2qq4ngq	199	30	of	of	IN
cord-018572-e2qq4ngq	199	31	TGN38	TGN38	NNP
cord-018572-e2qq4ngq	199	32	and	and	CC
cord-018572-e2qq4ngq	199	33	mannose-6-phosphate	mannose-6-phosphate	NNP
cord-018572-e2qq4ngq	199	34	receptor	receptor	NN
cord-018572-e2qq4ngq	199	35	trafficking	traffic	VBG
cord-018572-e2qq4ngq	199	36	from	from	IN
cord-018572-e2qq4ngq	199	37	there	there	RB
cord-018572-e2qq4ngq	199	38	back	back	RB
cord-018572-e2qq4ngq	199	39	to	to	IN
cord-018572-e2qq4ngq	199	40	the	the	DT
cord-018572-e2qq4ngq	199	41	TGN	TGN	NNP
cord-018572-e2qq4ngq	199	42	(	(	-LRB-
cord-018572-e2qq4ngq	199	43	Nakai	Nakai	NNP
cord-018572-e2qq4ngq	199	44	et	et	NNP
cord-018572-e2qq4ngq	199	45	al	al	NNP
cord-018572-e2qq4ngq	199	46	.	.	NNP
cord-018572-e2qq4ngq	199	47	2013	2013	CD
cord-018572-e2qq4ngq	199	48	)	)	-RRB-
cord-018572-e2qq4ngq	199	49	.	.	.
cord-018572-e2qq4ngq	200	1	How	how	WRB
cord-018572-e2qq4ngq	200	2	these	these	DT
cord-018572-e2qq4ngq	200	3	roles	role	NNS
cord-018572-e2qq4ngq	200	4	of	of	IN
cord-018572-e2qq4ngq	200	5	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	200	6	and	and	CC
cord-018572-e2qq4ngq	200	7	5	5	CD
cord-018572-e2qq4ngq	200	8	at	at	IN
cord-018572-e2qq4ngq	200	9	the	the	DT
cord-018572-e2qq4ngq	200	10	TGN	TGN	NNP
cord-018572-e2qq4ngq	200	11	in	in	IN
cord-018572-e2qq4ngq	200	12	cells	cell	NNS
cord-018572-e2qq4ngq	200	13	can	can	MD
cord-018572-e2qq4ngq	200	14	be	be	VB
cord-018572-e2qq4ngq	200	15	reconciled	reconcile	VBN
cord-018572-e2qq4ngq	200	16	with	with	IN
cord-018572-e2qq4ngq	200	17	findings	finding	NNS
cord-018572-e2qq4ngq	200	18	of	of	IN
cord-018572-e2qq4ngq	200	19	Arf4	arf4	JJ
cord-018572-e2qq4ngq	200	20	localization	localization	NN
cord-018572-e2qq4ngq	200	21	to	to	IN
cord-018572-e2qq4ngq	200	22	,	,	,
cord-018572-e2qq4ngq	200	23	and	and	CC
cord-018572-e2qq4ngq	200	24	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	200	25	and	and	CC
cord-018572-e2qq4ngq	200	26	5	5	CD
cord-018572-e2qq4ngq	200	27	functioning	function	VBG
cord-018572-e2qq4ngq	200	28	at	at	IN
cord-018572-e2qq4ngq	200	29	,	,	,
cord-018572-e2qq4ngq	200	30	the	the	DT
cord-018572-e2qq4ngq	200	31	early	early	JJ
cord-018572-e2qq4ngq	200	32	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	200	33	A	A	NNP
cord-018572-e2qq4ngq	200	34	recent	recent	JJ
cord-018572-e2qq4ngq	200	35	study	study	NN
cord-018572-e2qq4ngq	200	36	has	have	VBZ
cord-018572-e2qq4ngq	200	37	found	find	VBN
cord-018572-e2qq4ngq	200	38	a	a	DT
cord-018572-e2qq4ngq	200	39	specific	specific	JJ
cord-018572-e2qq4ngq	200	40	role	role	NN
cord-018572-e2qq4ngq	200	41	for	for	IN
cord-018572-e2qq4ngq	200	42	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	200	43	in	in	IN
cord-018572-e2qq4ngq	200	44	mediating	mediate	VBG
cord-018572-e2qq4ngq	200	45	brefeldin	brefeldin	NNS
cord-018572-e2qq4ngq	201	1	A	a	LS
cord-018572-e2qq4ngq	201	2	-	-	HYPH
cord-018572-e2qq4ngq	201	3	induced	induce	VBN
cord-018572-e2qq4ngq	201	4	apoptosis	apoptosis	NN
cord-018572-e2qq4ngq	201	5	,	,	,
cord-018572-e2qq4ngq	201	6	a	a	DT
cord-018572-e2qq4ngq	201	7	pathway	pathway	NN
cord-018572-e2qq4ngq	201	8	used	use	VBN
cord-018572-e2qq4ngq	201	9	by	by	IN
cord-018572-e2qq4ngq	201	10	human	human	JJ
cord-018572-e2qq4ngq	201	11	pathogens	pathogen	NNS
cord-018572-e2qq4ngq	201	12	such	such	JJ
cord-018572-e2qq4ngq	201	13	as	as	IN
cord-018572-e2qq4ngq	201	14	Chlamydia	Chlamydia	NNP
cord-018572-e2qq4ngq	201	15	trachomatis	trachomatis	NN
cord-018572-e2qq4ngq	201	16	and	and	CC
cord-018572-e2qq4ngq	201	17	Shigella	Shigella	NNP
cord-018572-e2qq4ngq	201	18	flexneri	flexneri	NN
cord-018572-e2qq4ngq	201	19	(	(	-LRB-
cord-018572-e2qq4ngq	201	20	Reiling	Reiling	NNP
cord-018572-e2qq4ngq	201	21	et	et	FW
cord-018572-e2qq4ngq	201	22	al	al	NNP
cord-018572-e2qq4ngq	201	23	.	.	NNP
cord-018572-e2qq4ngq	201	24	2013	2013	CD
cord-018572-e2qq4ngq	201	25	)	)	-RRB-
cord-018572-e2qq4ngq	201	26	.	.	.
cord-018572-e2qq4ngq	202	1	In	in	IN
cord-018572-e2qq4ngq	202	2	response	response	NN
cord-018572-e2qq4ngq	202	3	to	to	IN
cord-018572-e2qq4ngq	202	4	brefeldin	brefeldin	NNP
cord-018572-e2qq4ngq	202	5	A	A	NNP
cord-018572-e2qq4ngq	202	6	and	and	CC
cord-018572-e2qq4ngq	202	7	other	other	JJ
cord-018572-e2qq4ngq	202	8	Golgi	golgi	NN
cord-018572-e2qq4ngq	202	9	-	-	HYPH
cord-018572-e2qq4ngq	202	10	disrupting	disrupt	VBG
cord-018572-e2qq4ngq	202	11	agents	agent	NNS
cord-018572-e2qq4ngq	202	12	,	,	,
cord-018572-e2qq4ngq	202	13	cells	cell	NNS
cord-018572-e2qq4ngq	202	14	upregulate	upregulate	VBP
cord-018572-e2qq4ngq	202	15	expression	expression	NN
cord-018572-e2qq4ngq	202	16	of	of	IN
cord-018572-e2qq4ngq	202	17	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	202	18	at	at	IN
cord-018572-e2qq4ngq	202	19	the	the	DT
cord-018572-e2qq4ngq	202	20	transcriptional	transcriptional	JJ
cord-018572-e2qq4ngq	202	21	level	level	NN
cord-018572-e2qq4ngq	202	22	,	,	,
cord-018572-e2qq4ngq	202	23	through	through	IN
cord-018572-e2qq4ngq	202	24	proteolytic	proteolytic	JJ
cord-018572-e2qq4ngq	202	25	activation	activation	NN
cord-018572-e2qq4ngq	202	26	of	of	IN
cord-018572-e2qq4ngq	202	27	the	the	DT
cord-018572-e2qq4ngq	202	28	basic	basic	JJ
cord-018572-e2qq4ngq	202	29	leucine	leucine	NN
cord-018572-e2qq4ngq	202	30	zipper	zipper	NN
cord-018572-e2qq4ngq	202	31	transcription	transcription	NN
cord-018572-e2qq4ngq	202	32	factor	factor	NN
cord-018572-e2qq4ngq	202	33	CREB3	CREB3	NNS
cord-018572-e2qq4ngq	202	34	at	at	IN
cord-018572-e2qq4ngq	202	35	the	the	DT
cord-018572-e2qq4ngq	202	36	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	202	37	(	(	-LRB-
cord-018572-e2qq4ngq	202	38	Reiling	Reiling	NNP
cord-018572-e2qq4ngq	202	39	et	et	FW
cord-018572-e2qq4ngq	202	40	al	al	NNP
cord-018572-e2qq4ngq	202	41	.	.	NNP
cord-018572-e2qq4ngq	202	42	2013	2013	CD
cord-018572-e2qq4ngq	202	43	)	)	-RRB-
cord-018572-e2qq4ngq	202	44	.	.	.
cord-018572-e2qq4ngq	203	1	Interestingly	interestingly	RB
cord-018572-e2qq4ngq	203	2	,	,	,
cord-018572-e2qq4ngq	203	3	a	a	DT
cord-018572-e2qq4ngq	203	4	previous	previous	JJ
cord-018572-e2qq4ngq	203	5	study	study	NN
cord-018572-e2qq4ngq	203	6	found	find	VBD
cord-018572-e2qq4ngq	203	7	that	that	IN
cord-018572-e2qq4ngq	203	8	knockdown	knockdown	NN
cord-018572-e2qq4ngq	203	9	of	of	IN
cord-018572-e2qq4ngq	203	10	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	203	11	caused	cause	VBD
cord-018572-e2qq4ngq	203	12	an	an	DT
cord-018572-e2qq4ngq	203	13	upregulation	upregulation	NN
cord-018572-e2qq4ngq	203	14	of	of	IN
cord-018572-e2qq4ngq	203	15	the	the	DT
cord-018572-e2qq4ngq	203	16	unfolded	unfolded	JJ
cord-018572-e2qq4ngq	203	17	protein	protein	NN
cord-018572-e2qq4ngq	203	18	response	response	NN
cord-018572-e2qq4ngq	203	19	and	and	CC
cord-018572-e2qq4ngq	203	20	apoptosis	apoptosis	NN
cord-018572-e2qq4ngq	204	1	(	(	-LRB-
cord-018572-e2qq4ngq	204	2	Citterio	Citterio	NNP
cord-018572-e2qq4ngq	204	3	et	et	NNP
cord-018572-e2qq4ngq	204	4	al	al	NNP
cord-018572-e2qq4ngq	204	5	.	.	NNP
cord-018572-e2qq4ngq	204	6	2008	2008	CD
cord-018572-e2qq4ngq	204	7	)	)	-RRB-
cord-018572-e2qq4ngq	204	8	,	,	,
cord-018572-e2qq4ngq	204	9	possibly	possibly	RB
cord-018572-e2qq4ngq	204	10	through	through	IN
cord-018572-e2qq4ngq	204	11	this	this	DT
cord-018572-e2qq4ngq	204	12	newly	newly	RB
cord-018572-e2qq4ngq	204	13	defined	define	VBN
cord-018572-e2qq4ngq	204	14	CREB3/	creb3/	JJ
cord-018572-e2qq4ngq	205	1	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	205	2	pathway	pathway	NN
cord-018572-e2qq4ngq	205	3	.	.	.
cord-018572-e2qq4ngq	206	1	These	these	DT
cord-018572-e2qq4ngq	206	2	results	result	NNS
cord-018572-e2qq4ngq	206	3	suggest	suggest	VBP
cord-018572-e2qq4ngq	206	4	that	that	IN
cord-018572-e2qq4ngq	206	5	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	206	6	stress	stress	NN
cord-018572-e2qq4ngq	206	7	might	may	MD
cord-018572-e2qq4ngq	206	8	trigger	trigger	VB
cord-018572-e2qq4ngq	206	9	a	a	DT
cord-018572-e2qq4ngq	206	10	response	response	NN
cord-018572-e2qq4ngq	206	11	through	through	IN
cord-018572-e2qq4ngq	206	12	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	206	13	aimed	aim	VBN
cord-018572-e2qq4ngq	206	14	at	at	IN
cord-018572-e2qq4ngq	206	15	re	re	NN
cord-018572-e2qq4ngq	206	16	-	-	VBG
cord-018572-e2qq4ngq	206	17	establishing	establish	VBG
cord-018572-e2qq4ngq	206	18	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	206	19	function	function	NN
cord-018572-e2qq4ngq	206	20	,	,	,
cord-018572-e2qq4ngq	206	21	and	and	CC
cord-018572-e2qq4ngq	206	22	if	if	IN
cord-018572-e2qq4ngq	206	23	this	this	DT
cord-018572-e2qq4ngq	206	24	fails	fail	VBZ
cord-018572-e2qq4ngq	206	25	,	,	,
cord-018572-e2qq4ngq	206	26	mediate	mediate	VB
cord-018572-e2qq4ngq	206	27	a	a	DT
cord-018572-e2qq4ngq	206	28	switch	switch	NN
cord-018572-e2qq4ngq	206	29	to	to	IN
cord-018572-e2qq4ngq	206	30	induction	induction	NN
cord-018572-e2qq4ngq	206	31	of	of	IN
cord-018572-e2qq4ngq	206	32	apoptosis	apoptosis	NN
cord-018572-e2qq4ngq	206	33	(	(	-LRB-
cord-018572-e2qq4ngq	206	34	Reiling	Reiling	NNP
cord-018572-e2qq4ngq	206	35	et	et	FW
cord-018572-e2qq4ngq	206	36	al	al	NNP
cord-018572-e2qq4ngq	206	37	.	.	NNP
cord-018572-e2qq4ngq	206	38	2013	2013	CD
cord-018572-e2qq4ngq	206	39	)	)	-RRB-
cord-018572-e2qq4ngq	206	40	.	.	.
cord-018572-e2qq4ngq	207	1	A	a	DT
cord-018572-e2qq4ngq	207	2	novel	novel	JJ
cord-018572-e2qq4ngq	207	3	function	function	NN
cord-018572-e2qq4ngq	207	4	for	for	IN
cord-018572-e2qq4ngq	207	5	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	207	6	in	in	IN
cord-018572-e2qq4ngq	207	7	lipid	lipid	NN
cord-018572-e2qq4ngq	207	8	droplet	droplet	NN
cord-018572-e2qq4ngq	207	9	(	(	-LRB-
cord-018572-e2qq4ngq	207	10	LD	LD	NNP
cord-018572-e2qq4ngq	207	11	)	)	-RRB-
cord-018572-e2qq4ngq	207	12	metabolism	metabolism	NN
cord-018572-e2qq4ngq	207	13	has	have	VBZ
cord-018572-e2qq4ngq	207	14	been	be	VBN
cord-018572-e2qq4ngq	207	15	uncovered	uncover	VBN
cord-018572-e2qq4ngq	207	16	recently	recently	RB
cord-018572-e2qq4ngq	208	1	(	(	-LRB-
cord-018572-e2qq4ngq	208	2	Beller	Beller	NNP
cord-018572-e2qq4ngq	208	3	et	et	NNP
cord-018572-e2qq4ngq	208	4	al	al	NNP
cord-018572-e2qq4ngq	208	5	.	.	.
cord-018572-e2qq4ngq	209	1	2008	2008	CD
cord-018572-e2qq4ngq	209	2	;	;	:
cord-018572-e2qq4ngq	209	3	Guo	Guo	NNP
cord-018572-e2qq4ngq	209	4	et	et	FW
cord-018572-e2qq4ngq	209	5	al	al	NNP
cord-018572-e2qq4ngq	209	6	.	.	.
cord-018572-e2qq4ngq	210	1	2008	2008	CD
cord-018572-e2qq4ngq	210	2	;	;	:
cord-018572-e2qq4ngq	210	3	Soni	Soni	NNP
cord-018572-e2qq4ngq	210	4	et	et	FW
cord-018572-e2qq4ngq	210	5	al	al	NNP
cord-018572-e2qq4ngq	210	6	.	.	NNP
cord-018572-e2qq4ngq	210	7	2009	2009	CD
cord-018572-e2qq4ngq	210	8	)	)	-RRB-
cord-018572-e2qq4ngq	210	9	.	.	.
cord-018572-e2qq4ngq	211	1	Lipid	lipid	NN
cord-018572-e2qq4ngq	211	2	droplets	droplet	NNS
cord-018572-e2qq4ngq	211	3	are	be	VBP
cord-018572-e2qq4ngq	211	4	well	well	RB
cord-018572-e2qq4ngq	211	5	known	known	JJ
cord-018572-e2qq4ngq	211	6	for	for	IN
cord-018572-e2qq4ngq	211	7	their	-PRON-	PRP$
cord-018572-e2qq4ngq	211	8	function	function	NN
cord-018572-e2qq4ngq	211	9	in	in	IN
cord-018572-e2qq4ngq	211	10	storage	storage	NN
cord-018572-e2qq4ngq	211	11	of	of	IN
cord-018572-e2qq4ngq	211	12	energy	energy	NN
cord-018572-e2qq4ngq	211	13	in	in	IN
cord-018572-e2qq4ngq	211	14	the	the	DT
cord-018572-e2qq4ngq	211	15	form	form	NN
cord-018572-e2qq4ngq	211	16	of	of	IN
cord-018572-e2qq4ngq	211	17	triglycerides	triglyceride	NNS
cord-018572-e2qq4ngq	211	18	(	(	-LRB-
cord-018572-e2qq4ngq	211	19	Ducharme	Ducharme	NNP
cord-018572-e2qq4ngq	211	20	and	and	CC
cord-018572-e2qq4ngq	211	21	Bickel	Bickel	NNP
cord-018572-e2qq4ngq	211	22	2008	2008	CD
cord-018572-e2qq4ngq	211	23	;	;	:
cord-018572-e2qq4ngq	211	24	Londos	Londos	NNP
cord-018572-e2qq4ngq	211	25	et	et	NNP
cord-018572-e2qq4ngq	211	26	al	al	NNP
cord-018572-e2qq4ngq	211	27	.	.	NNP
cord-018572-e2qq4ngq	211	28	2005	2005	CD
cord-018572-e2qq4ngq	211	29	)	)	-RRB-
cord-018572-e2qq4ngq	211	30	.	.	.
cord-018572-e2qq4ngq	212	1	More	more	RBR
cord-018572-e2qq4ngq	212	2	recently	recently	RB
cord-018572-e2qq4ngq	212	3	,	,	,
cord-018572-e2qq4ngq	212	4	their	-PRON-	PRP$
cord-018572-e2qq4ngq	212	5	dynamic	dynamic	JJ
cord-018572-e2qq4ngq	212	6	structure	structure	NN
cord-018572-e2qq4ngq	212	7	and	and	CC
cord-018572-e2qq4ngq	212	8	integration	integration	NN
cord-018572-e2qq4ngq	212	9	with	with	IN
cord-018572-e2qq4ngq	212	10	membrane	membrane	NN
cord-018572-e2qq4ngq	212	11	trafficking	traffic	VBG
cord-018572-e2qq4ngq	212	12	pathways	pathway	NNS
cord-018572-e2qq4ngq	212	13	have	have	VBP
cord-018572-e2qq4ngq	212	14	revealed	reveal	VBN
cord-018572-e2qq4ngq	212	15	that	that	IN
cord-018572-e2qq4ngq	212	16	they	-PRON-	PRP
cord-018572-e2qq4ngq	212	17	are	be	VBP
cord-018572-e2qq4ngq	212	18	in	in	IN
cord-018572-e2qq4ngq	212	19	fact	fact	NN
cord-018572-e2qq4ngq	212	20	bona	bona	FW
cord-018572-e2qq4ngq	212	21	fide	fide	JJ
cord-018572-e2qq4ngq	212	22	organelles	organelle	NNS
cord-018572-e2qq4ngq	212	23	(	(	-LRB-
cord-018572-e2qq4ngq	212	24	Walther	Walther	NNP
cord-018572-e2qq4ngq	212	25	and	and	CC
cord-018572-e2qq4ngq	212	26	Farese	farese	JJ
cord-018572-e2qq4ngq	212	27	2012	2012	CD
cord-018572-e2qq4ngq	212	28	)	)	-RRB-
cord-018572-e2qq4ngq	212	29	.	.	.
cord-018572-e2qq4ngq	213	1	LDs	LDs	NNP
cord-018572-e2qq4ngq	213	2	are	be	VBP
cord-018572-e2qq4ngq	213	3	distinct	distinct	JJ
cord-018572-e2qq4ngq	213	4	from	from	IN
cord-018572-e2qq4ngq	213	5	other	other	JJ
cord-018572-e2qq4ngq	213	6	organelles	organelle	NNS
cord-018572-e2qq4ngq	213	7	in	in	IN
cord-018572-e2qq4ngq	213	8	having	have	VBG
cord-018572-e2qq4ngq	213	9	a	a	DT
cord-018572-e2qq4ngq	213	10	neutral	neutral	JJ
cord-018572-e2qq4ngq	213	11	lipid	lipid	NN
cord-018572-e2qq4ngq	213	12	core	core	NN
cord-018572-e2qq4ngq	213	13	surrounded	surround	VBN
cord-018572-e2qq4ngq	213	14	by	by	IN
cord-018572-e2qq4ngq	213	15	a	a	DT
cord-018572-e2qq4ngq	213	16	phospholipid	phospholipid	NN
cord-018572-e2qq4ngq	213	17	monolayer	monolayer	NN
cord-018572-e2qq4ngq	214	1	(	(	-LRB-
cord-018572-e2qq4ngq	214	2	Tauchi	Tauchi	NNP
cord-018572-e2qq4ngq	214	3	-	-	HYPH
cord-018572-e2qq4ngq	214	4	Sato	Sato	NNP
cord-018572-e2qq4ngq	214	5	et	et	FW
cord-018572-e2qq4ngq	214	6	al	al	NNP
cord-018572-e2qq4ngq	214	7	.	.	.
cord-018572-e2qq4ngq	214	8	2002	2002	CD
cord-018572-e2qq4ngq	214	9	)	)	-RRB-
cord-018572-e2qq4ngq	214	10	,	,	,
cord-018572-e2qq4ngq	214	11	rather	rather	RB
cord-018572-e2qq4ngq	214	12	than	than	IN
cord-018572-e2qq4ngq	214	13	a	a	DT
cord-018572-e2qq4ngq	214	14	bilayer	bilayer	NN
cord-018572-e2qq4ngq	214	15	encompassing	encompass	VBG
cord-018572-e2qq4ngq	214	16	an	an	DT
cord-018572-e2qq4ngq	214	17	aqueous	aqueous	JJ
cord-018572-e2qq4ngq	214	18	interior	interior	NN
cord-018572-e2qq4ngq	214	19	.	.	.
cord-018572-e2qq4ngq	215	1	In	in	IN
cord-018572-e2qq4ngq	215	2	addition	addition	NN
cord-018572-e2qq4ngq	215	3	to	to	IN
cord-018572-e2qq4ngq	215	4	triglycerides	triglyceride	NNS
cord-018572-e2qq4ngq	215	5	,	,	,
cord-018572-e2qq4ngq	215	6	which	which	WDT
cord-018572-e2qq4ngq	215	7	are	be	VBP
cord-018572-e2qq4ngq	215	8	the	the	DT
cord-018572-e2qq4ngq	215	9	major	major	JJ
cord-018572-e2qq4ngq	215	10	energy	energy	NN
cord-018572-e2qq4ngq	215	11	storage	storage	NN
cord-018572-e2qq4ngq	215	12	molecules	molecule	NNS
cord-018572-e2qq4ngq	215	13	of	of	IN
cord-018572-e2qq4ngq	215	14	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	215	15	cells	cell	NNS
cord-018572-e2qq4ngq	215	16	,	,	,
cord-018572-e2qq4ngq	215	17	the	the	DT
cord-018572-e2qq4ngq	215	18	neutral	neutral	JJ
cord-018572-e2qq4ngq	215	19	lipid	lipid	NN
cord-018572-e2qq4ngq	215	20	core	core	NN
cord-018572-e2qq4ngq	215	21	of	of	IN
cord-018572-e2qq4ngq	215	22	LDs	LDs	NNP
cord-018572-e2qq4ngq	215	23	also	also	RB
cord-018572-e2qq4ngq	215	24	contains	contain	VBZ
cord-018572-e2qq4ngq	215	25	esterified	esterified	JJ
cord-018572-e2qq4ngq	215	26	cholesterol	cholesterol	NN
cord-018572-e2qq4ngq	215	27	.	.	.
cord-018572-e2qq4ngq	216	1	These	these	DT
cord-018572-e2qq4ngq	216	2	two	two	CD
cord-018572-e2qq4ngq	216	3	classes	class	NNS
cord-018572-e2qq4ngq	216	4	of	of	IN
cord-018572-e2qq4ngq	216	5	neutral	neutral	JJ
cord-018572-e2qq4ngq	216	6	lipids	lipid	NNS
cord-018572-e2qq4ngq	216	7	serve	serve	VBP
cord-018572-e2qq4ngq	216	8	as	as	IN
cord-018572-e2qq4ngq	216	9	storage	storage	NN
cord-018572-e2qq4ngq	216	10	precursors	precursor	NNS
cord-018572-e2qq4ngq	216	11	of	of	IN
cord-018572-e2qq4ngq	216	12	the	the	DT
cord-018572-e2qq4ngq	216	13	two	two	CD
cord-018572-e2qq4ngq	216	14	major	major	JJ
cord-018572-e2qq4ngq	216	15	lipid	lipid	NN
cord-018572-e2qq4ngq	216	16	components	component	NNS
cord-018572-e2qq4ngq	216	17	of	of	IN
cord-018572-e2qq4ngq	216	18	cellular	cellular	JJ
cord-018572-e2qq4ngq	216	19	membranes	membrane	NNS
cord-018572-e2qq4ngq	216	20	.	.	.
cord-018572-e2qq4ngq	217	1	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	217	2	,	,	,
cord-018572-e2qq4ngq	217	3	along	along	IN
cord-018572-e2qq4ngq	217	4	with	with	IN
cord-018572-e2qq4ngq	217	5	its	-PRON-	PRP$
cord-018572-e2qq4ngq	217	6	GEF	GEF	NNP
cord-018572-e2qq4ngq	217	7	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	217	8	and	and	CC
cord-018572-e2qq4ngq	217	9	effector	effector	VB
cord-018572-e2qq4ngq	217	10	COPI	COPI	NNP
cord-018572-e2qq4ngq	217	11	,	,	,
cord-018572-e2qq4ngq	217	12	associates	associate	NNS
cord-018572-e2qq4ngq	217	13	with	with	IN
cord-018572-e2qq4ngq	217	14	LDs	LDs	NNP
cord-018572-e2qq4ngq	217	15	(	(	-LRB-
cord-018572-e2qq4ngq	217	16	Fig	Fig	NNP
cord-018572-e2qq4ngq	217	17	.	.	.
cord-018572-e2qq4ngq	217	18	8	8	CD
cord-018572-e2qq4ngq	217	19	.3	.3	NFP
cord-018572-e2qq4ngq	217	20	)	)	-RRB-
cord-018572-e2qq4ngq	217	21	and	and	CC
cord-018572-e2qq4ngq	217	22	is	be	VBZ
cord-018572-e2qq4ngq	217	23	required	require	VBN
cord-018572-e2qq4ngq	217	24	for	for	IN
cord-018572-e2qq4ngq	217	25	recruitment	recruitment	NN
cord-018572-e2qq4ngq	217	26	of	of	IN
cord-018572-e2qq4ngq	217	27	a	a	DT
cord-018572-e2qq4ngq	217	28	subset	subset	NN
cord-018572-e2qq4ngq	217	29	of	of	IN
cord-018572-e2qq4ngq	217	30	lipid	lipid	NN
cord-018572-e2qq4ngq	217	31	droplet	droplet	NN
cord-018572-e2qq4ngq	217	32	associated	associate	VBD
cord-018572-e2qq4ngq	217	33	proteins	protein	NNS
cord-018572-e2qq4ngq	217	34	to	to	IN
cord-018572-e2qq4ngq	217	35	the	the	DT
cord-018572-e2qq4ngq	217	36	LD	LD	NNP
cord-018572-e2qq4ngq	217	37	surface	surface	NN
cord-018572-e2qq4ngq	217	38	(	(	-LRB-
cord-018572-e2qq4ngq	217	39	Soni	Soni	NNP
cord-018572-e2qq4ngq	217	40	et	et	FW
cord-018572-e2qq4ngq	217	41	al	al	NNP
cord-018572-e2qq4ngq	217	42	.	.	NNP
cord-018572-e2qq4ngq	217	43	2009	2009	CD
cord-018572-e2qq4ngq	217	44	)	)	-RRB-
cord-018572-e2qq4ngq	217	45	.	.	.
cord-018572-e2qq4ngq	218	1	In	in	IN
cord-018572-e2qq4ngq	218	2	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	218	3	cells	cell	NNS
cord-018572-e2qq4ngq	218	4	,	,	,
cord-018572-e2qq4ngq	218	5	these	these	DT
cord-018572-e2qq4ngq	218	6	LD	LD	NNP
cord-018572-e2qq4ngq	218	7	components	component	NNS
cord-018572-e2qq4ngq	218	8	include	include	VBP
cord-018572-e2qq4ngq	218	9	a	a	DT
cord-018572-e2qq4ngq	218	10	triglyceride	triglyceride	NN
cord-018572-e2qq4ngq	218	11	lipase	lipase	NN
cord-018572-e2qq4ngq	218	12	(	(	-LRB-
cord-018572-e2qq4ngq	218	13	ATGL	ATGL	NNP
cord-018572-e2qq4ngq	218	14	)	)	-RRB-
cord-018572-e2qq4ngq	218	15	and	and	CC
cord-018572-e2qq4ngq	218	16	a	a	DT
cord-018572-e2qq4ngq	218	17	perilipin	perilipin	NNP
cord-018572-e2qq4ngq	218	18	family	family	NN
cord-018572-e2qq4ngq	218	19	member	member	NN
cord-018572-e2qq4ngq	218	20	(	(	-LRB-
cord-018572-e2qq4ngq	218	21	PLIN2	PLIN2	NNP
cord-018572-e2qq4ngq	218	22	)	)	-RRB-
cord-018572-e2qq4ngq	218	23	(	(	-LRB-
cord-018572-e2qq4ngq	218	24	Soni	Soni	NNP
cord-018572-e2qq4ngq	218	25	et	et	FW
cord-018572-e2qq4ngq	218	26	al	al	NNP
cord-018572-e2qq4ngq	218	27	.	.	.
cord-018572-e2qq4ngq	218	28	2009	2009	CD
cord-018572-e2qq4ngq	218	29	)	)	-RRB-
cord-018572-e2qq4ngq	218	30	,	,	,
cord-018572-e2qq4ngq	218	31	and	and	CC
cord-018572-e2qq4ngq	218	32	for	for	IN
cord-018572-e2qq4ngq	218	33	ATGL	ATGL	NNP
cord-018572-e2qq4ngq	218	34	at	at	IN
cord-018572-e2qq4ngq	218	35	least	least	JJS
cord-018572-e2qq4ngq	218	36	,	,	,
cord-018572-e2qq4ngq	218	37	this	this	DT
cord-018572-e2qq4ngq	218	38	function	function	NN
cord-018572-e2qq4ngq	218	39	is	be	VBZ
cord-018572-e2qq4ngq	218	40	conserved	conserve	VBN
cord-018572-e2qq4ngq	218	41	in	in	IN
cord-018572-e2qq4ngq	218	42	Drosophila	Drosophila	NNP
cord-018572-e2qq4ngq	218	43	(	(	-LRB-
cord-018572-e2qq4ngq	218	44	Beller	Beller	NNP
cord-018572-e2qq4ngq	218	45	et	et	NNP
cord-018572-e2qq4ngq	218	46	al	al	NNP
cord-018572-e2qq4ngq	218	47	.	.	NNP
cord-018572-e2qq4ngq	218	48	2008	2008	CD
cord-018572-e2qq4ngq	218	49	)	)	-RRB-
cord-018572-e2qq4ngq	218	50	.	.	.
cord-018572-e2qq4ngq	219	1	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	219	2	itself	-PRON-	PRP
cord-018572-e2qq4ngq	219	3	is	be	VBZ
cord-018572-e2qq4ngq	219	4	recruited	recruit	VBN
cord-018572-e2qq4ngq	219	5	to	to	IN
cord-018572-e2qq4ngq	219	6	LDs	LDs	NNP
cord-018572-e2qq4ngq	219	7	via	via	IN
cord-018572-e2qq4ngq	219	8	HDS1	HDS1	NNP
cord-018572-e2qq4ngq	219	9	,	,	,
cord-018572-e2qq4ngq	219	10	the	the	DT
cord-018572-e2qq4ngq	219	11	domain	domain	NN
cord-018572-e2qq4ngq	219	12	just	just	RB
cord-018572-e2qq4ngq	219	13	downstream	downstream	RB
cord-018572-e2qq4ngq	219	14	of	of	IN
cord-018572-e2qq4ngq	219	15	the	the	DT
cord-018572-e2qq4ngq	219	16	catalytic	catalytic	JJ
cord-018572-e2qq4ngq	219	17	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	219	18	domain	domain	NN
cord-018572-e2qq4ngq	219	19	,	,	,
cord-018572-e2qq4ngq	219	20	which	which	WDT
cord-018572-e2qq4ngq	219	21	binds	bind	VBZ
cord-018572-e2qq4ngq	219	22	both	both	DT
cord-018572-e2qq4ngq	219	23	liposomes	liposome	NNS
cord-018572-e2qq4ngq	219	24	and	and	CC
cord-018572-e2qq4ngq	219	25	artificial	artificial	JJ
cord-018572-e2qq4ngq	219	26	droplets	droplet	NNS
cord-018572-e2qq4ngq	219	27	directly	directly	RB
cord-018572-e2qq4ngq	219	28	in	in	IN
cord-018572-e2qq4ngq	219	29	vitro	vitro	FW
cord-018572-e2qq4ngq	219	30	(	(	-LRB-
cord-018572-e2qq4ngq	219	31	Bouvet	Bouvet	NNP
cord-018572-e2qq4ngq	219	32	et	et	NNP
cord-018572-e2qq4ngq	219	33	al	al	NNP
cord-018572-e2qq4ngq	219	34	.	.	NNP
cord-018572-e2qq4ngq	219	35	2013	2013	CD
cord-018572-e2qq4ngq	219	36	)	)	-RRB-
cord-018572-e2qq4ngq	219	37	.	.	.
cord-018572-e2qq4ngq	220	1	This	this	DT
cord-018572-e2qq4ngq	220	2	domain	domain	NN
cord-018572-e2qq4ngq	220	3	and	and	CC
cord-018572-e2qq4ngq	220	4	the	the	DT
cord-018572-e2qq4ngq	220	5	downstream	downstream	JJ
cord-018572-e2qq4ngq	220	6	HDS2	HDS2	NNP
cord-018572-e2qq4ngq	220	7	domain	domain	NN
cord-018572-e2qq4ngq	220	8	are	be	VBP
cord-018572-e2qq4ngq	220	9	both	both	DT
cord-018572-e2qq4ngq	220	10	required	require	VBN
cord-018572-e2qq4ngq	220	11	for	for	IN
cord-018572-e2qq4ngq	220	12	localization	localization	NN
cord-018572-e2qq4ngq	220	13	of	of	IN
cord-018572-e2qq4ngq	220	14	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	220	15	to	to	IN
cord-018572-e2qq4ngq	220	16	the	the	DT
cord-018572-e2qq4ngq	220	17	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	220	18	.	.	.
cord-018572-e2qq4ngq	221	1	However	however	RB
cord-018572-e2qq4ngq	221	2	,	,	,
cord-018572-e2qq4ngq	221	3	when	when	WRB
cord-018572-e2qq4ngq	221	4	expressed	express	VBN
cord-018572-e2qq4ngq	221	5	alone	alone	RB
cord-018572-e2qq4ngq	221	6	as	as	IN
cord-018572-e2qq4ngq	221	7	GFP	GFP	NNP
cord-018572-e2qq4ngq	221	8	fusions	fusion	NNS
cord-018572-e2qq4ngq	221	9	in	in	IN
cord-018572-e2qq4ngq	221	10	cells	cell	NNS
cord-018572-e2qq4ngq	221	11	,	,	,
cord-018572-e2qq4ngq	221	12	HDS1	HDS1	NNP
cord-018572-e2qq4ngq	221	13	and	and	CC
cord-018572-e2qq4ngq	221	14	HDS2	HDS2	NNP
cord-018572-e2qq4ngq	221	15	are	be	VBP
cord-018572-e2qq4ngq	221	16	targeted	target	VBN
cord-018572-e2qq4ngq	221	17	only	only	RB
cord-018572-e2qq4ngq	221	18	to	to	IN
cord-018572-e2qq4ngq	221	19	LDs	LDs	NNP
cord-018572-e2qq4ngq	221	20	,	,	,
cord-018572-e2qq4ngq	221	21	not	not	RB
cord-018572-e2qq4ngq	221	22	to	to	IN
cord-018572-e2qq4ngq	221	23	the	the	DT
cord-018572-e2qq4ngq	221	24	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	221	25	(	(	-LRB-
cord-018572-e2qq4ngq	221	26	Ellong	Ellong	NNP
cord-018572-e2qq4ngq	221	27	et	et	FW
cord-018572-e2qq4ngq	221	28	al	al	NNP
cord-018572-e2qq4ngq	221	29	.	.	NNP
cord-018572-e2qq4ngq	221	30	2011	2011	CD
cord-018572-e2qq4ngq	221	31	)	)	-RRB-
cord-018572-e2qq4ngq	221	32	.	.	.
cord-018572-e2qq4ngq	222	1	The	the	DT
cord-018572-e2qq4ngq	222	2	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	222	3	domain	domain	NN
cord-018572-e2qq4ngq	222	4	regulates	regulate	VBZ
cord-018572-e2qq4ngq	222	5	HDS1	HDS1	NNP
cord-018572-e2qq4ngq	222	6	association	association	NN
cord-018572-e2qq4ngq	222	7	with	with	IN
cord-018572-e2qq4ngq	222	8	membranes	membrane	NNS
cord-018572-e2qq4ngq	222	9	,	,	,
cord-018572-e2qq4ngq	222	10	acting	act	VBG
cord-018572-e2qq4ngq	222	11	as	as	IN
cord-018572-e2qq4ngq	222	12	an	an	DT
cord-018572-e2qq4ngq	222	13	inhibitor	inhibitor	NN
cord-018572-e2qq4ngq	222	14	of	of	IN
cord-018572-e2qq4ngq	222	15	localization	localization	NN
cord-018572-e2qq4ngq	222	16	,	,	,
cord-018572-e2qq4ngq	222	17	and	and	CC
cord-018572-e2qq4ngq	222	18	the	the	DT
cord-018572-e2qq4ngq	222	19	N	n	CD
cord-018572-e2qq4ngq	222	20	-	-	HYPH
cord-018572-e2qq4ngq	222	21	terminal	terminal	NN
cord-018572-e2qq4ngq	222	22	DCB	DCB	NNP
cord-018572-e2qq4ngq	222	23	and	and	CC
cord-018572-e2qq4ngq	222	24	HUS	HUS	NNP
cord-018572-e2qq4ngq	222	25	domains	domain	NNS
cord-018572-e2qq4ngq	222	26	are	be	VBP
cord-018572-e2qq4ngq	222	27	required	require	VBN
cord-018572-e2qq4ngq	222	28	in	in	IN
cord-018572-e2qq4ngq	222	29	addition	addition	NN
cord-018572-e2qq4ngq	222	30	to	to	TO
cord-018572-e2qq4ngq	222	31	target	target	VB
cord-018572-e2qq4ngq	222	32	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	222	33	to	to	IN
cord-018572-e2qq4ngq	222	34	the	the	DT
cord-018572-e2qq4ngq	222	35	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	222	36	(	(	-LRB-
cord-018572-e2qq4ngq	222	37	Bouvet	Bouvet	NNP
cord-018572-e2qq4ngq	222	38	et	et	NNP
cord-018572-e2qq4ngq	222	39	al	al	NNP
cord-018572-e2qq4ngq	222	40	.	.	NNP
cord-018572-e2qq4ngq	222	41	2013	2013	CD
cord-018572-e2qq4ngq	222	42	)	)	-RRB-
cord-018572-e2qq4ngq	222	43	.	.	.
cord-018572-e2qq4ngq	223	1	B.	B.	NNP
cord-018572-e2qq4ngq	223	2	Antonny	Antonny	NNP
cord-018572-e2qq4ngq	223	3	and	and	CC
cord-018572-e2qq4ngq	223	4	colleagues	colleague	NNS
cord-018572-e2qq4ngq	223	5	have	have	VBP
cord-018572-e2qq4ngq	223	6	proposed	propose	VBN
cord-018572-e2qq4ngq	223	7	a	a	DT
cord-018572-e2qq4ngq	223	8	novel	novel	JJ
cord-018572-e2qq4ngq	223	9	mechanism	mechanism	NN
cord-018572-e2qq4ngq	223	10	of	of	IN
cord-018572-e2qq4ngq	223	11	protein	protein	NN
cord-018572-e2qq4ngq	223	12	recruitment	recruitment	NN
cord-018572-e2qq4ngq	223	13	to	to	IN
cord-018572-e2qq4ngq	223	14	the	the	DT
cord-018572-e2qq4ngq	223	15	unique	unique	JJ
cord-018572-e2qq4ngq	223	16	surface	surface	NN
cord-018572-e2qq4ngq	223	17	of	of	IN
cord-018572-e2qq4ngq	223	18	LDs	LDs	NNP
cord-018572-e2qq4ngq	223	19	.	.	.
cord-018572-e2qq4ngq	224	1	In	in	IN
cord-018572-e2qq4ngq	224	2	a	a	DT
cord-018572-e2qq4ngq	224	3	recent	recent	JJ
cord-018572-e2qq4ngq	224	4	study	study	NN
cord-018572-e2qq4ngq	224	5	,	,	,
cord-018572-e2qq4ngq	224	6	they	-PRON-	PRP
cord-018572-e2qq4ngq	224	7	demonstrated	demonstrate	VBD
cord-018572-e2qq4ngq	224	8	that	that	IN
cord-018572-e2qq4ngq	224	9	the	the	DT
cord-018572-e2qq4ngq	224	10	density	density	NN
cord-018572-e2qq4ngq	224	11	of	of	IN
cord-018572-e2qq4ngq	224	12	phospholipids	phospholipid	NNS
cord-018572-e2qq4ngq	224	13	in	in	IN
cord-018572-e2qq4ngq	224	14	the	the	DT
cord-018572-e2qq4ngq	224	15	monolayer	monolayer	NN
cord-018572-e2qq4ngq	224	16	surrounding	surround	VBG
cord-018572-e2qq4ngq	224	17	the	the	DT
cord-018572-e2qq4ngq	224	18	neutral	neutral	JJ
cord-018572-e2qq4ngq	224	19	lipid	lipid	NN
cord-018572-e2qq4ngq	224	20	core	core	NN
cord-018572-e2qq4ngq	224	21	of	of	IN
cord-018572-e2qq4ngq	224	22	an	an	DT
cord-018572-e2qq4ngq	224	23	artificial	artificial	JJ
cord-018572-e2qq4ngq	224	24	LD	LD	NNP
cord-018572-e2qq4ngq	224	25	could	could	MD
cord-018572-e2qq4ngq	224	26	be	be	VB
cord-018572-e2qq4ngq	224	27	decreased	decrease	VBN
cord-018572-e2qq4ngq	224	28	,	,	,
cord-018572-e2qq4ngq	224	29	leading	lead	VBG
cord-018572-e2qq4ngq	224	30	as	as	IN
cord-018572-e2qq4ngq	224	31	expected	expect	VBN
cord-018572-e2qq4ngq	224	32	to	to	IN
cord-018572-e2qq4ngq	224	33	an	an	DT
cord-018572-e2qq4ngq	224	34	increase	increase	NN
cord-018572-e2qq4ngq	224	35	in	in	IN
cord-018572-e2qq4ngq	224	36	surface	surface	NN
cord-018572-e2qq4ngq	224	37	tension	tension	NN
cord-018572-e2qq4ngq	224	38	(	(	-LRB-
cord-018572-e2qq4ngq	225	1	Thiam	Thiam	NNP
cord-018572-e2qq4ngq	225	2	et	et	NNP
cord-018572-e2qq4ngq	225	3	al	al	NNP
cord-018572-e2qq4ngq	225	4	.	.	NNP
cord-018572-e2qq4ngq	225	5	2013	2013	CD
cord-018572-e2qq4ngq	225	6	)	)	-RRB-
cord-018572-e2qq4ngq	225	7	.	.	.
cord-018572-e2qq4ngq	226	1	Hence	hence	RB
cord-018572-e2qq4ngq	226	2	in	in	IN
cord-018572-e2qq4ngq	226	3	contrast	contrast	NN
cord-018572-e2qq4ngq	226	4	to	to	IN
cord-018572-e2qq4ngq	226	5	a	a	DT
cord-018572-e2qq4ngq	226	6	bilayer	bilayer	NN
cord-018572-e2qq4ngq	226	7	,	,	,
cord-018572-e2qq4ngq	226	8	which	which	WDT
cord-018572-e2qq4ngq	226	9	would	would	MD
cord-018572-e2qq4ngq	226	10	tear	tear	VB
cord-018572-e2qq4ngq	226	11	with	with	IN
cord-018572-e2qq4ngq	226	12	even	even	RB
cord-018572-e2qq4ngq	226	13	a	a	DT
cord-018572-e2qq4ngq	226	14	small	small	JJ
cord-018572-e2qq4ngq	226	15	decrease	decrease	NN
cord-018572-e2qq4ngq	226	16	in	in	IN
cord-018572-e2qq4ngq	226	17	phospholipid	phospholipid	NN
cord-018572-e2qq4ngq	226	18	density	density	NN
cord-018572-e2qq4ngq	226	19	in	in	IN
cord-018572-e2qq4ngq	226	20	one	one	CD
cord-018572-e2qq4ngq	226	21	leaflet	leaflet	NN
cord-018572-e2qq4ngq	226	22	,	,	,
cord-018572-e2qq4ngq	226	23	the	the	DT
cord-018572-e2qq4ngq	226	24	phospholipids	phospholipid	NNS
cord-018572-e2qq4ngq	226	25	of	of	IN
cord-018572-e2qq4ngq	226	26	the	the	DT
cord-018572-e2qq4ngq	226	27	LD	LD	NNP
cord-018572-e2qq4ngq	226	28	surface	surface	NN
cord-018572-e2qq4ngq	226	29	can	can	MD
cord-018572-e2qq4ngq	226	30	be	be	VB
cord-018572-e2qq4ngq	226	31	spread	spread	VBN
cord-018572-e2qq4ngq	226	32	apart	apart	RB
cord-018572-e2qq4ngq	226	33	,	,	,
cord-018572-e2qq4ngq	226	34	albeit	albeit	IN
cord-018572-e2qq4ngq	226	35	with	with	IN
cord-018572-e2qq4ngq	226	36	the	the	DT
cord-018572-e2qq4ngq	226	37	unfavourable	unfavourable	JJ
cord-018572-e2qq4ngq	226	38	effect	effect	NN
cord-018572-e2qq4ngq	226	39	of	of	IN
cord-018572-e2qq4ngq	226	40	exposing	expose	VBG
cord-018572-e2qq4ngq	226	41	the	the	DT
cord-018572-e2qq4ngq	226	42	hydrophobic	hydrophobic	JJ
cord-018572-e2qq4ngq	226	43	core	core	NN
cord-018572-e2qq4ngq	226	44	to	to	IN
cord-018572-e2qq4ngq	226	45	the	the	DT
cord-018572-e2qq4ngq	226	46	aqueous	aqueous	JJ
cord-018572-e2qq4ngq	226	47	environment	environment	NN
cord-018572-e2qq4ngq	226	48	of	of	IN
cord-018572-e2qq4ngq	226	49	the	the	DT
cord-018572-e2qq4ngq	226	50	cytosol	cytosol	NN
cord-018572-e2qq4ngq	226	51	.	.	.
cord-018572-e2qq4ngq	227	1	This	this	DT
cord-018572-e2qq4ngq	227	2	increase	increase	NN
cord-018572-e2qq4ngq	227	3	in	in	IN
cord-018572-e2qq4ngq	227	4	surface	surface	NN
cord-018572-e2qq4ngq	227	5	tension	tension	NN
cord-018572-e2qq4ngq	227	6	could	could	MD
cord-018572-e2qq4ngq	227	7	favour	favour	VB
cord-018572-e2qq4ngq	227	8	the	the	DT
cord-018572-e2qq4ngq	227	9	recruitment	recruitment	NN
cord-018572-e2qq4ngq	227	10	of	of	IN
cord-018572-e2qq4ngq	227	11	cytosolic	cytosolic	JJ
cord-018572-e2qq4ngq	227	12	proteins	protein	NNS
cord-018572-e2qq4ngq	227	13	to	to	IN
cord-018572-e2qq4ngq	227	14	the	the	DT
cord-018572-e2qq4ngq	227	15	LD	LD	NNP
cord-018572-e2qq4ngq	227	16	,	,	,
cord-018572-e2qq4ngq	227	17	which	which	WDT
cord-018572-e2qq4ngq	227	18	would	would	MD
cord-018572-e2qq4ngq	227	19	compensate	compensate	VB
cord-018572-e2qq4ngq	227	20	for	for	IN
cord-018572-e2qq4ngq	227	21	the	the	DT
cord-018572-e2qq4ngq	227	22	lower	low	JJR
cord-018572-e2qq4ngq	227	23	density	density	NN
cord-018572-e2qq4ngq	227	24	of	of	IN
cord-018572-e2qq4ngq	227	25	phospholipids	phospholipid	NNS
cord-018572-e2qq4ngq	227	26	by	by	IN
cord-018572-e2qq4ngq	227	27	helping	help	VBG
cord-018572-e2qq4ngq	227	28	to	to	TO
cord-018572-e2qq4ngq	227	29	cover	cover	VB
cord-018572-e2qq4ngq	227	30	the	the	DT
cord-018572-e2qq4ngq	227	31	LD	LD	NNP
cord-018572-e2qq4ngq	227	32	surface	surface	NN
cord-018572-e2qq4ngq	227	33	.	.	.
cord-018572-e2qq4ngq	228	1	B.	B.	NNP
cord-018572-e2qq4ngq	228	2	Antonny	Antonny	NNP
cord-018572-e2qq4ngq	228	3	and	and	CC
cord-018572-e2qq4ngq	228	4	F.	F.	NNP
cord-018572-e2qq4ngq	228	5	Pincet	Pincet	NNP
cord-018572-e2qq4ngq	228	6	further	further	RB
cord-018572-e2qq4ngq	228	7	hypothesized	hypothesize	VBD
cord-018572-e2qq4ngq	228	8	that	that	IN
cord-018572-e2qq4ngq	228	9	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	228	10	,	,	,
cord-018572-e2qq4ngq	228	11	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	228	12	,	,	,
cord-018572-e2qq4ngq	228	13	and	and	CC
cord-018572-e2qq4ngq	228	14	COPI	COPI	NNP
cord-018572-e2qq4ngq	228	15	might	may	MD
cord-018572-e2qq4ngq	228	16	function	function	VB
cord-018572-e2qq4ngq	228	17	to	to	TO
cord-018572-e2qq4ngq	228	18	recruit	recruit	VB
cord-018572-e2qq4ngq	228	19	proteins	protein	NNS
cord-018572-e2qq4ngq	228	20	to	to	IN
cord-018572-e2qq4ngq	228	21	LDs	LDs	NNP
cord-018572-e2qq4ngq	228	22	by	by	IN
cord-018572-e2qq4ngq	228	23	decreasing	decrease	VBG
cord-018572-e2qq4ngq	228	24	phospholipid	phospholipid	NN
cord-018572-e2qq4ngq	228	25	density	density	NN
cord-018572-e2qq4ngq	228	26	,	,	,
cord-018572-e2qq4ngq	228	27	as	as	IN
cord-018572-e2qq4ngq	228	28	a	a	DT
cord-018572-e2qq4ngq	228	29	result	result	NN
cord-018572-e2qq4ngq	228	30	of	of	IN
cord-018572-e2qq4ngq	228	31	their	-PRON-	PRP$
cord-018572-e2qq4ngq	228	32	removal	removal	NN
cord-018572-e2qq4ngq	228	33	by	by	IN
cord-018572-e2qq4ngq	228	34	budding	bud	VBG
cord-018572-e2qq4ngq	228	35	of	of	IN
cord-018572-e2qq4ngq	228	36	small	small	JJ
cord-018572-e2qq4ngq	228	37	droplets	droplet	NNS
cord-018572-e2qq4ngq	228	38	from	from	IN
cord-018572-e2qq4ngq	228	39	the	the	DT
cord-018572-e2qq4ngq	228	40	surface	surface	NN
cord-018572-e2qq4ngq	228	41	of	of	IN
cord-018572-e2qq4ngq	228	42	a	a	DT
cord-018572-e2qq4ngq	228	43	large	large	JJ
cord-018572-e2qq4ngq	228	44	LD	LD	NNP
cord-018572-e2qq4ngq	228	45	.	.	.
cord-018572-e2qq4ngq	229	1	Indeed	indeed	RB
cord-018572-e2qq4ngq	229	2	,	,	,
cord-018572-e2qq4ngq	229	3	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	229	4	and	and	CC
cord-018572-e2qq4ngq	229	5	COPI	COPI	NNP
cord-018572-e2qq4ngq	229	6	were	be	VBD
cord-018572-e2qq4ngq	229	7	sufficient	sufficient	JJ
cord-018572-e2qq4ngq	229	8	to	to	TO
cord-018572-e2qq4ngq	229	9	cause	cause	VB
cord-018572-e2qq4ngq	229	10	budding	bud	VBG
cord-018572-e2qq4ngq	229	11	of	of	IN
cord-018572-e2qq4ngq	229	12	60	60	CD
cord-018572-e2qq4ngq	229	13	-	-	SYM
cord-018572-e2qq4ngq	229	14	100	100	CD
cord-018572-e2qq4ngq	229	15	nm	nm	NN
cord-018572-e2qq4ngq	229	16	diameter	diameter	NN
cord-018572-e2qq4ngq	229	17	droplets	droplet	NNS
cord-018572-e2qq4ngq	229	18	from	from	IN
cord-018572-e2qq4ngq	229	19	an	an	DT
cord-018572-e2qq4ngq	229	20	artificial	artificial	JJ
cord-018572-e2qq4ngq	229	21	droplet	droplet	NN
cord-018572-e2qq4ngq	229	22	surface	surface	NN
cord-018572-e2qq4ngq	229	23	in	in	IN
cord-018572-e2qq4ngq	229	24	vitro	vitro	FW
cord-018572-e2qq4ngq	230	1	(	(	-LRB-
cord-018572-e2qq4ngq	230	2	Thiam	Thiam	NNP
cord-018572-e2qq4ngq	230	3	et	et	NNP
cord-018572-e2qq4ngq	230	4	al	al	NNP
cord-018572-e2qq4ngq	230	5	.	.	NNP
cord-018572-e2qq4ngq	230	6	2013	2013	CD
cord-018572-e2qq4ngq	230	7	)	)	-RRB-
cord-018572-e2qq4ngq	230	8	.	.	.
cord-018572-e2qq4ngq	231	1	In	in	IN
cord-018572-e2qq4ngq	231	2	support	support	NN
cord-018572-e2qq4ngq	231	3	of	of	IN
cord-018572-e2qq4ngq	231	4	their	-PRON-	PRP$
cord-018572-e2qq4ngq	231	5	hypothesis	hypothesis	NN
cord-018572-e2qq4ngq	231	6	,	,	,
cord-018572-e2qq4ngq	231	7	these	these	DT
cord-018572-e2qq4ngq	231	8	authors	author	NNS
cord-018572-e2qq4ngq	231	9	then	then	RB
cord-018572-e2qq4ngq	231	10	found	find	VBD
cord-018572-e2qq4ngq	231	11	that	that	IN
cord-018572-e2qq4ngq	231	12	the	the	DT
cord-018572-e2qq4ngq	231	13	binding	binding	NN
cord-018572-e2qq4ngq	231	14	of	of	IN
cord-018572-e2qq4ngq	231	15	α	α	NNP
cord-018572-e2qq4ngq	231	16	-	-	HYPH
cord-018572-e2qq4ngq	231	17	synuclein	synuclein	NNP
cord-018572-e2qq4ngq	231	18	,	,	,
cord-018572-e2qq4ngq	231	19	known	know	VBN
cord-018572-e2qq4ngq	231	20	to	to	TO
cord-018572-e2qq4ngq	231	21	associate	associate	VB
cord-018572-e2qq4ngq	231	22	with	with	IN
cord-018572-e2qq4ngq	231	23	LDs	LDs	NNP
cord-018572-e2qq4ngq	231	24	in	in	IN
cord-018572-e2qq4ngq	231	25	cells	cell	NNS
cord-018572-e2qq4ngq	231	26	(	(	-LRB-
cord-018572-e2qq4ngq	231	27	Cole	Cole	NNP
cord-018572-e2qq4ngq	231	28	et	et	NNP
cord-018572-e2qq4ngq	231	29	al	al	NNP
cord-018572-e2qq4ngq	231	30	.	.	.
cord-018572-e2qq4ngq	231	31	2002	2002	CD
cord-018572-e2qq4ngq	231	32	)	)	-RRB-
cord-018572-e2qq4ngq	231	33	,	,	,
cord-018572-e2qq4ngq	231	34	was	be	VBD
cord-018572-e2qq4ngq	231	35	promoted	promote	VBN
cord-018572-e2qq4ngq	231	36	when	when	WRB
cord-018572-e2qq4ngq	231	37	the	the	DT
cord-018572-e2qq4ngq	231	38	phospholipid	phospholipid	NN
cord-018572-e2qq4ngq	231	39	density	density	NN
cord-018572-e2qq4ngq	231	40	of	of	IN
cord-018572-e2qq4ngq	231	41	artificial	artificial	JJ
cord-018572-e2qq4ngq	231	42	droplets	droplet	NNS
cord-018572-e2qq4ngq	231	43	decreased	decrease	VBD
cord-018572-e2qq4ngq	231	44	(	(	-LRB-
cord-018572-e2qq4ngq	231	45	Thiam	Thiam	NNP
cord-018572-e2qq4ngq	231	46	et	et	NNP
cord-018572-e2qq4ngq	231	47	al	al	NNP
cord-018572-e2qq4ngq	231	48	.	.	NNP
cord-018572-e2qq4ngq	231	49	2013	2013	CD
cord-018572-e2qq4ngq	231	50	)	)	-RRB-
cord-018572-e2qq4ngq	231	51	.	.	.
cord-018572-e2qq4ngq	232	1	This	this	DT
cord-018572-e2qq4ngq	232	2	result	result	NN
cord-018572-e2qq4ngq	232	3	supports	support	VBZ
cord-018572-e2qq4ngq	232	4	the	the	DT
cord-018572-e2qq4ngq	232	5	hypothesis	hypothesis	NN
cord-018572-e2qq4ngq	232	6	that	that	IN
cord-018572-e2qq4ngq	232	7	LDs	LDs	NNP
cord-018572-e2qq4ngq	232	8	can	can	MD
cord-018572-e2qq4ngq	232	9	become	become	VB
cord-018572-e2qq4ngq	232	10	more	more	RBR
cord-018572-e2qq4ngq	232	11	"	"	``
cord-018572-e2qq4ngq	232	12	reactive	reactive	JJ
cord-018572-e2qq4ngq	232	13	"	"	''
cord-018572-e2qq4ngq	232	14	when	when	WRB
cord-018572-e2qq4ngq	232	15	they	-PRON-	PRP
cord-018572-e2qq4ngq	232	16	experience	experience	VBP
cord-018572-e2qq4ngq	232	17	a	a	DT
cord-018572-e2qq4ngq	232	18	decrease	decrease	NN
cord-018572-e2qq4ngq	232	19	in	in	IN
cord-018572-e2qq4ngq	232	20	phospholipid	phospholipid	NN
cord-018572-e2qq4ngq	232	21	density	density	NN
cord-018572-e2qq4ngq	232	22	on	on	IN
cord-018572-e2qq4ngq	232	23	their	-PRON-	PRP$
cord-018572-e2qq4ngq	232	24	surface	surface	NN
cord-018572-e2qq4ngq	232	25	,	,	,
cord-018572-e2qq4ngq	232	26	because	because	IN
cord-018572-e2qq4ngq	232	27	of	of	IN
cord-018572-e2qq4ngq	232	28	the	the	DT
cord-018572-e2qq4ngq	232	29	unfavourable	unfavourable	JJ
cord-018572-e2qq4ngq	232	30	increase	increase	NN
cord-018572-e2qq4ngq	232	31	in	in	IN
cord-018572-e2qq4ngq	232	32	surface	surface	NN
cord-018572-e2qq4ngq	232	33	tension	tension	NN
cord-018572-e2qq4ngq	232	34	.	.	.
cord-018572-e2qq4ngq	233	1	Together	together	RB
cord-018572-e2qq4ngq	233	2	,	,	,
cord-018572-e2qq4ngq	233	3	these	these	DT
cord-018572-e2qq4ngq	233	4	findings	finding	NNS
cord-018572-e2qq4ngq	233	5	provide	provide	VBP
cord-018572-e2qq4ngq	233	6	an	an	DT
cord-018572-e2qq4ngq	233	7	elegant	elegant	JJ
cord-018572-e2qq4ngq	233	8	explanation	explanation	NN
cord-018572-e2qq4ngq	233	9	for	for	IN
cord-018572-e2qq4ngq	233	10	the	the	DT
cord-018572-e2qq4ngq	233	11	function	function	NN
cord-018572-e2qq4ngq	233	12	of	of	IN
cord-018572-e2qq4ngq	233	13	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	233	14	,	,	,
cord-018572-e2qq4ngq	233	15	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	233	16	,	,	,
cord-018572-e2qq4ngq	233	17	and	and	CC
cord-018572-e2qq4ngq	233	18	COPI	COPI	NNP
cord-018572-e2qq4ngq	233	19	in	in	IN
cord-018572-e2qq4ngq	233	20	recruitment	recruitment	NN
cord-018572-e2qq4ngq	233	21	of	of	IN
cord-018572-e2qq4ngq	233	22	proteins	protein	NNS
cord-018572-e2qq4ngq	233	23	to	to	IN
cord-018572-e2qq4ngq	233	24	the	the	DT
cord-018572-e2qq4ngq	233	25	LD	LD	NNP
cord-018572-e2qq4ngq	233	26	surface	surface	NN
cord-018572-e2qq4ngq	233	27	.	.	.
cord-018572-e2qq4ngq	234	1	In	in	IN
cord-018572-e2qq4ngq	234	2	addition	addition	NN
cord-018572-e2qq4ngq	234	3	to	to	IN
cord-018572-e2qq4ngq	234	4	its	-PRON-	PRP$
cord-018572-e2qq4ngq	234	5	function	function	NN
cord-018572-e2qq4ngq	234	6	in	in	IN
cord-018572-e2qq4ngq	234	7	lipid	lipid	NN
cord-018572-e2qq4ngq	234	8	metabolism	metabolism	NN
cord-018572-e2qq4ngq	234	9	of	of	IN
cord-018572-e2qq4ngq	234	10	LDs	LDs	NNP
cord-018572-e2qq4ngq	234	11	,	,	,
cord-018572-e2qq4ngq	234	12	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	234	13	has	have	VBZ
cord-018572-e2qq4ngq	234	14	an	an	DT
cord-018572-e2qq4ngq	234	15	important	important	JJ
cord-018572-e2qq4ngq	234	16	function	function	NN
cord-018572-e2qq4ngq	234	17	in	in	IN
cord-018572-e2qq4ngq	234	18	lipid	lipid	NN
cord-018572-e2qq4ngq	234	19	trafficking	trafficking	NN
cord-018572-e2qq4ngq	234	20	at	at	IN
cord-018572-e2qq4ngq	234	21	the	the	DT
cord-018572-e2qq4ngq	234	22	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	234	23	that	that	WDT
cord-018572-e2qq4ngq	234	24	is	be	VBZ
cord-018572-e2qq4ngq	234	25	distinct	distinct	JJ
cord-018572-e2qq4ngq	234	26	from	from	IN
cord-018572-e2qq4ngq	234	27	its	-PRON-	PRP$
cord-018572-e2qq4ngq	234	28	role	role	NN
cord-018572-e2qq4ngq	234	29	in	in	IN
cord-018572-e2qq4ngq	234	30	vesicle	vesicle	NN
cord-018572-e2qq4ngq	234	31	formation	formation	NN
cord-018572-e2qq4ngq	234	32	.	.	.
cord-018572-e2qq4ngq	235	1	A	a	DT
cord-018572-e2qq4ngq	235	2	number	number	NN
cord-018572-e2qq4ngq	235	3	of	of	IN
cord-018572-e2qq4ngq	235	4	lipid	lipid	NN
cord-018572-e2qq4ngq	235	5	transfer	transfer	NN
cord-018572-e2qq4ngq	235	6	proteins	protein	NNS
cord-018572-e2qq4ngq	235	7	are	be	VBP
cord-018572-e2qq4ngq	235	8	recruited	recruit	VBN
cord-018572-e2qq4ngq	235	9	by	by	IN
cord-018572-e2qq4ngq	235	10	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	235	11	to	to	IN
cord-018572-e2qq4ngq	235	12	membranes	membrane	NNS
cord-018572-e2qq4ngq	235	13	at	at	IN
cord-018572-e2qq4ngq	235	14	sites	site	NNS
cord-018572-e2qq4ngq	235	15	of	of	IN
cord-018572-e2qq4ngq	235	16	close	close	JJ
cord-018572-e2qq4ngq	235	17	contact	contact	NN
cord-018572-e2qq4ngq	235	18	between	between	IN
cord-018572-e2qq4ngq	235	19	the	the	DT
cord-018572-e2qq4ngq	235	20	ER	ER	NNP
cord-018572-e2qq4ngq	235	21	and	and	CC
cord-018572-e2qq4ngq	235	22	other	other	JJ
cord-018572-e2qq4ngq	235	23	organelles	organelle	NNS
cord-018572-e2qq4ngq	235	24	,	,	,
cord-018572-e2qq4ngq	235	25	known	know	VBN
cord-018572-e2qq4ngq	235	26	as	as	IN
cord-018572-e2qq4ngq	235	27	membrane	membrane	NN
cord-018572-e2qq4ngq	235	28	contact	contact	NN
cord-018572-e2qq4ngq	235	29	sites	site	NNS
cord-018572-e2qq4ngq	235	30	(	(	-LRB-
cord-018572-e2qq4ngq	235	31	MCS	MCS	NNP
cord-018572-e2qq4ngq	235	32	)	)	-RRB-
cord-018572-e2qq4ngq	236	1	(	(	-LRB-
cord-018572-e2qq4ngq	236	2	Levine	Levine	NNP
cord-018572-e2qq4ngq	236	3	and	and	CC
cord-018572-e2qq4ngq	236	4	Rabouille	Rabouille	NNP
cord-018572-e2qq4ngq	236	5	2005	2005	CD
cord-018572-e2qq4ngq	236	6	;	;	:
cord-018572-e2qq4ngq	236	7	Stefan	Stefan	NNP
cord-018572-e2qq4ngq	236	8	et	et	NNP
cord-018572-e2qq4ngq	236	9	al	al	NNP
cord-018572-e2qq4ngq	236	10	.	.	NNP
cord-018572-e2qq4ngq	236	11	2013	2013	CD
cord-018572-e2qq4ngq	236	12	)	)	-RRB-
cord-018572-e2qq4ngq	236	13	.	.	.
cord-018572-e2qq4ngq	237	1	FAPP2	FAPP2	NNP
cord-018572-e2qq4ngq	237	2	,	,	,
cord-018572-e2qq4ngq	237	3	CERT	CERT	NNP
cord-018572-e2qq4ngq	237	4	,	,	,
cord-018572-e2qq4ngq	237	5	and	and	CC
cord-018572-e2qq4ngq	237	6	OSBP	OSBP	NNP
cord-018572-e2qq4ngq	237	7	transfer	transfer	NN
cord-018572-e2qq4ngq	237	8	glucosylceramide	glucosylceramide	NN
cord-018572-e2qq4ngq	237	9	,	,	,
cord-018572-e2qq4ngq	237	10	ceramide	ceramide	NN
cord-018572-e2qq4ngq	237	11	,	,	,
cord-018572-e2qq4ngq	237	12	and	and	CC
cord-018572-e2qq4ngq	237	13	sterol	sterol	NN
cord-018572-e2qq4ngq	237	14	,	,	,
cord-018572-e2qq4ngq	237	15	respectively	respectively	RB
cord-018572-e2qq4ngq	237	16	,	,	,
cord-018572-e2qq4ngq	237	17	and	and	CC
cord-018572-e2qq4ngq	237	18	all	all	DT
cord-018572-e2qq4ngq	237	19	three	three	CD
cord-018572-e2qq4ngq	237	20	possess	possess	VBP
cord-018572-e2qq4ngq	237	21	a	a	DT
cord-018572-e2qq4ngq	237	22	PH	PH	NNP
cord-018572-e2qq4ngq	237	23	domain	domain	NN
cord-018572-e2qq4ngq	237	24	that	that	WDT
cord-018572-e2qq4ngq	237	25	requires	require	VBZ
cord-018572-e2qq4ngq	237	26	both	both	DT
cord-018572-e2qq4ngq	237	27	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	237	28	and	and	CC
cord-018572-e2qq4ngq	237	29	PI4P	PI4P	VBN
cord-018572-e2qq4ngq	237	30	in	in	IN
cord-018572-e2qq4ngq	237	31	order	order	NN
cord-018572-e2qq4ngq	237	32	to	to	TO
cord-018572-e2qq4ngq	237	33	bind	bind	VB
cord-018572-e2qq4ngq	237	34	to	to	IN
cord-018572-e2qq4ngq	237	35	trans	trans	NNP
cord-018572-e2qq4ngq	237	36	-	-	JJ
cord-018572-e2qq4ngq	237	37	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	237	38	membranes	membrane	NNS
cord-018572-e2qq4ngq	237	39	(	(	-LRB-
cord-018572-e2qq4ngq	237	40	De	De	NNP
cord-018572-e2qq4ngq	237	41	Matteis	Matteis	NNP
cord-018572-e2qq4ngq	237	42	and	and	CC
cord-018572-e2qq4ngq	237	43	Godi	Godi	NNP
cord-018572-e2qq4ngq	237	44	2004b	2004b	CD
cord-018572-e2qq4ngq	237	45	)	)	-RRB-
cord-018572-e2qq4ngq	238	1	(	(	-LRB-
cord-018572-e2qq4ngq	238	2	Table	table	NN
cord-018572-e2qq4ngq	238	3	8	8	CD
cord-018572-e2qq4ngq	238	4	.1	.1	CD
cord-018572-e2qq4ngq	238	5	)	)	-RRB-
cord-018572-e2qq4ngq	238	6	.	.	.
cord-018572-e2qq4ngq	239	1	The	the	DT
cord-018572-e2qq4ngq	239	2	first	first	JJ
cord-018572-e2qq4ngq	239	3	clue	clue	NN
cord-018572-e2qq4ngq	239	4	that	that	IN
cord-018572-e2qq4ngq	239	5	these	these	DT
cord-018572-e2qq4ngq	239	6	proteins	protein	NNS
cord-018572-e2qq4ngq	239	7	might	may	MD
cord-018572-e2qq4ngq	239	8	bridge	bridge	VB
cord-018572-e2qq4ngq	239	9	two	two	CD
cord-018572-e2qq4ngq	239	10	different	different	JJ
cord-018572-e2qq4ngq	239	11	organelles	organelle	NNS
cord-018572-e2qq4ngq	239	12	came	come	VBD
cord-018572-e2qq4ngq	239	13	from	from	IN
cord-018572-e2qq4ngq	239	14	studies	study	NNS
cord-018572-e2qq4ngq	239	15	indicating	indicate	VBG
cord-018572-e2qq4ngq	239	16	that	that	IN
cord-018572-e2qq4ngq	239	17	in	in	IN
cord-018572-e2qq4ngq	239	18	addition	addition	NN
cord-018572-e2qq4ngq	239	19	to	to	IN
cord-018572-e2qq4ngq	239	20	a	a	DT
cord-018572-e2qq4ngq	239	21	late	late	JJ
cord-018572-e2qq4ngq	239	22	Golgi	golgi	NN
cord-018572-e2qq4ngq	239	23	-	-	HYPH
cord-018572-e2qq4ngq	239	24	specific	specific	JJ
cord-018572-e2qq4ngq	239	25	PH	PH	NNP
cord-018572-e2qq4ngq	239	26	domain	domain	NN
cord-018572-e2qq4ngq	239	27	,	,	,
cord-018572-e2qq4ngq	239	28	they	-PRON-	PRP
cord-018572-e2qq4ngq	239	29	also	also	RB
cord-018572-e2qq4ngq	239	30	carry	carry	VBP
cord-018572-e2qq4ngq	239	31	a	a	DT
cord-018572-e2qq4ngq	239	32	motif	motif	NN
cord-018572-e2qq4ngq	239	33	mediating	mediate	VBG
cord-018572-e2qq4ngq	239	34	binding	bind	VBG
cord-018572-e2qq4ngq	239	35	to	to	IN
cord-018572-e2qq4ngq	239	36	the	the	DT
cord-018572-e2qq4ngq	239	37	ER	ER	NNP
cord-018572-e2qq4ngq	239	38	-	-	HYPH
cord-018572-e2qq4ngq	239	39	localized	localize	VBN
cord-018572-e2qq4ngq	239	40	protein	protein	NN
cord-018572-e2qq4ngq	239	41	VAP	VAP	NNP
cord-018572-e2qq4ngq	239	42	(	(	-LRB-
cord-018572-e2qq4ngq	239	43	Lev	Lev	NNP
cord-018572-e2qq4ngq	239	44	2010	2010	CD
cord-018572-e2qq4ngq	239	45	;	;	:
cord-018572-e2qq4ngq	239	46	Levine	Levine	NNP
cord-018572-e2qq4ngq	239	47	and	and	CC
cord-018572-e2qq4ngq	239	48	Loewen	Loewen	NNP
cord-018572-e2qq4ngq	239	49	2006	2006	CD
cord-018572-e2qq4ngq	239	50	)	)	-RRB-
cord-018572-e2qq4ngq	239	51	.	.	.
cord-018572-e2qq4ngq	240	1	A	a	DT
cord-018572-e2qq4ngq	240	2	recent	recent	JJ
cord-018572-e2qq4ngq	240	3	study	study	NN
cord-018572-e2qq4ngq	240	4	showed	show	VBD
cord-018572-e2qq4ngq	240	5	that	that	IN
cord-018572-e2qq4ngq	240	6	these	these	DT
cord-018572-e2qq4ngq	240	7	two	two	CD
cord-018572-e2qq4ngq	240	8	localization	localization	NN
cord-018572-e2qq4ngq	240	9	regions	region	NNS
cord-018572-e2qq4ngq	240	10	of	of	IN
cord-018572-e2qq4ngq	240	11	OSBP	OSBP	NNP
cord-018572-e2qq4ngq	240	12	are	be	VBP
cord-018572-e2qq4ngq	240	13	sufficient	sufficient	JJ
cord-018572-e2qq4ngq	240	14	to	to	TO
cord-018572-e2qq4ngq	240	15	mediate	mediate	VB
cord-018572-e2qq4ngq	240	16	contact	contact	NN
cord-018572-e2qq4ngq	240	17	between	between	IN
cord-018572-e2qq4ngq	240	18	the	the	DT
cord-018572-e2qq4ngq	240	19	ER	ER	NNP
cord-018572-e2qq4ngq	240	20	and	and	CC
cord-018572-e2qq4ngq	240	21	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	240	22	,	,	,
cord-018572-e2qq4ngq	240	23	and	and	CC
cord-018572-e2qq4ngq	240	24	moreover	moreover	RB
cord-018572-e2qq4ngq	240	25	,	,	,
cord-018572-e2qq4ngq	240	26	that	that	IN
cord-018572-e2qq4ngq	240	27	OSBP	OSBP	NNP
cord-018572-e2qq4ngq	240	28	activity	activity	NN
cord-018572-e2qq4ngq	240	29	regulates	regulate	VBZ
cord-018572-e2qq4ngq	240	30	this	this	DT
cord-018572-e2qq4ngq	240	31	association	association	NN
cord-018572-e2qq4ngq	240	32	(	(	-LRB-
cord-018572-e2qq4ngq	240	33	Mesmin	Mesmin	NNP
cord-018572-e2qq4ngq	240	34	et	et	NNP
cord-018572-e2qq4ngq	240	35	al	al	NNP
cord-018572-e2qq4ngq	240	36	.	.	NNP
cord-018572-e2qq4ngq	240	37	2013	2013	CD
cord-018572-e2qq4ngq	240	38	)	)	-RRB-
cord-018572-e2qq4ngq	240	39	.	.	.
cord-018572-e2qq4ngq	241	1	FAPP2-mediated	fapp2-mediate	VBN
cord-018572-e2qq4ngq	241	2	delivery	delivery	NN
cord-018572-e2qq4ngq	241	3	of	of	IN
cord-018572-e2qq4ngq	241	4	glucosylceramide	glucosylceramide	NN
cord-018572-e2qq4ngq	241	5	to	to	IN
cord-018572-e2qq4ngq	241	6	the	the	DT
cord-018572-e2qq4ngq	241	7	trans	trans	NNP
cord-018572-e2qq4ngq	241	8	-	-	NNP
cord-018572-e2qq4ngq	241	9	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	241	10	has	have	VBZ
cord-018572-e2qq4ngq	241	11	been	be	VBN
cord-018572-e2qq4ngq	241	12	shown	show	VBN
cord-018572-e2qq4ngq	241	13	to	to	TO
cord-018572-e2qq4ngq	241	14	be	be	VB
cord-018572-e2qq4ngq	241	15	dependent	dependent	JJ
cord-018572-e2qq4ngq	241	16	on	on	IN
cord-018572-e2qq4ngq	241	17	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	241	18	and	and	CC
cord-018572-e2qq4ngq	241	19	also	also	RB
cord-018572-e2qq4ngq	241	20	to	to	TO
cord-018572-e2qq4ngq	241	21	be	be	VB
cord-018572-e2qq4ngq	241	22	required	require	VBN
cord-018572-e2qq4ngq	241	23	for	for	IN
cord-018572-e2qq4ngq	241	24	vesicular	vesicular	JJ
cord-018572-e2qq4ngq	241	25	trafficking	trafficking	NN
cord-018572-e2qq4ngq	241	26	from	from	IN
cord-018572-e2qq4ngq	241	27	the	the	DT
cord-018572-e2qq4ngq	241	28	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	241	29	to	to	IN
cord-018572-e2qq4ngq	241	30	the	the	DT
cord-018572-e2qq4ngq	241	31	PM	pm	NN
cord-018572-e2qq4ngq	242	1	(	(	-LRB-
cord-018572-e2qq4ngq	242	2	D'Angelo	D'Angelo	NNP
cord-018572-e2qq4ngq	242	3	et	et	NNP
cord-018572-e2qq4ngq	242	4	al	al	NNP
cord-018572-e2qq4ngq	242	5	.	.	NNP
cord-018572-e2qq4ngq	242	6	2007	2007	CD
cord-018572-e2qq4ngq	242	7	)	)	-RRB-
cord-018572-e2qq4ngq	242	8	.	.	.
cord-018572-e2qq4ngq	243	1	Hence	hence	RB
cord-018572-e2qq4ngq	243	2	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	243	3	,	,	,
cord-018572-e2qq4ngq	243	4	by	by	IN
cord-018572-e2qq4ngq	243	5	recruiting	recruit	VBG
cord-018572-e2qq4ngq	243	6	proteins	protein	NNS
cord-018572-e2qq4ngq	243	7	that	that	WDT
cord-018572-e2qq4ngq	243	8	mediate	mediate	VBP
cord-018572-e2qq4ngq	243	9	transfer	transfer	NN
cord-018572-e2qq4ngq	243	10	of	of	IN
cord-018572-e2qq4ngq	243	11	sphingolipid	sphingolipid	NN
cord-018572-e2qq4ngq	243	12	precursors	precursor	NNS
cord-018572-e2qq4ngq	243	13	and	and	CC
cord-018572-e2qq4ngq	243	14	sterol	sterol	NN
cord-018572-e2qq4ngq	243	15	,	,	,
cord-018572-e2qq4ngq	243	16	plays	play	VBZ
cord-018572-e2qq4ngq	243	17	an	an	DT
cord-018572-e2qq4ngq	243	18	essential	essential	JJ
cord-018572-e2qq4ngq	243	19	role	role	NN
cord-018572-e2qq4ngq	243	20	in	in	IN
cord-018572-e2qq4ngq	243	21	establishing	establish	VBG
cord-018572-e2qq4ngq	243	22	the	the	DT
cord-018572-e2qq4ngq	243	23	characteristic	characteristic	JJ
cord-018572-e2qq4ngq	243	24	lipid	lipid	NN
cord-018572-e2qq4ngq	243	25	environment	environment	NN
cord-018572-e2qq4ngq	243	26	of	of	IN
cord-018572-e2qq4ngq	243	27	the	the	DT
cord-018572-e2qq4ngq	243	28	trans	trans	NNP
cord-018572-e2qq4ngq	243	29	-	-	NNP
cord-018572-e2qq4ngq	243	30	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	243	31	,	,	,
cord-018572-e2qq4ngq	243	32	PM	PM	NNP
cord-018572-e2qq4ngq	243	33	,	,	,
cord-018572-e2qq4ngq	243	34	and	and	CC
cord-018572-e2qq4ngq	243	35	endosomal	endosomal	NNP
cord-018572-e2qq4ngq	243	36	system	system	NN
cord-018572-e2qq4ngq	243	37	of	of	IN
cord-018572-e2qq4ngq	243	38	the	the	DT
cord-018572-e2qq4ngq	243	39	cell	cell	NN
cord-018572-e2qq4ngq	243	40	,	,	,
cord-018572-e2qq4ngq	243	41	an	an	DT
cord-018572-e2qq4ngq	243	42	important	important	JJ
cord-018572-e2qq4ngq	243	43	feature	feature	NN
cord-018572-e2qq4ngq	243	44	of	of	IN
cord-018572-e2qq4ngq	243	45	cellular	cellular	JJ
cord-018572-e2qq4ngq	243	46	organization	organization	NN
cord-018572-e2qq4ngq	243	47	(	(	-LRB-
cord-018572-e2qq4ngq	243	48	Bigay	Bigay	NNP
cord-018572-e2qq4ngq	243	49	and	and	CC
cord-018572-e2qq4ngq	243	50	Antonny	Antonny	NNP
cord-018572-e2qq4ngq	243	51	2012	2012	CD
cord-018572-e2qq4ngq	243	52	)	)	-RRB-
cord-018572-e2qq4ngq	243	53	.	.	.
cord-018572-e2qq4ngq	244	1	A	a	DT
cord-018572-e2qq4ngq	244	2	key	key	JJ
cord-018572-e2qq4ngq	244	3	question	question	NN
cord-018572-e2qq4ngq	244	4	regarding	regard	VBG
cord-018572-e2qq4ngq	244	5	these	these	DT
cord-018572-e2qq4ngq	244	6	transfer	transfer	NN
cord-018572-e2qq4ngq	244	7	proteins	protein	NNS
cord-018572-e2qq4ngq	244	8	is	be	VBZ
cord-018572-e2qq4ngq	244	9	how	how	WRB
cord-018572-e2qq4ngq	244	10	they	-PRON-	PRP
cord-018572-e2qq4ngq	244	11	transport	transport	VBP
cord-018572-e2qq4ngq	244	12	lipids	lipid	NNS
cord-018572-e2qq4ngq	244	13	such	such	JJ
cord-018572-e2qq4ngq	244	14	as	as	IN
cord-018572-e2qq4ngq	244	15	sterols	sterol	NNS
cord-018572-e2qq4ngq	244	16	up	up	RP
cord-018572-e2qq4ngq	244	17	their	-PRON-	PRP$
cord-018572-e2qq4ngq	244	18	concentration	concentration	NN
cord-018572-e2qq4ngq	244	19	gradient	gradient	NN
cord-018572-e2qq4ngq	244	20	.	.	.
cord-018572-e2qq4ngq	245	1	For	for	IN
cord-018572-e2qq4ngq	245	2	OSBP	OSBP	NNP
cord-018572-e2qq4ngq	245	3	,	,	,
cord-018572-e2qq4ngq	245	4	B.	B.	NNP
cord-018572-e2qq4ngq	245	5	Mesmin	Mesmin	NNP
cord-018572-e2qq4ngq	245	6	and	and	CC
cord-018572-e2qq4ngq	245	7	colleagues	colleague	NNS
cord-018572-e2qq4ngq	245	8	showed	show	VBD
cord-018572-e2qq4ngq	245	9	that	that	IN
cord-018572-e2qq4ngq	245	10	sterol	sterol	NN
cord-018572-e2qq4ngq	245	11	is	be	VBZ
cord-018572-e2qq4ngq	245	12	exchanged	exchange	VBN
cord-018572-e2qq4ngq	245	13	for	for	IN
cord-018572-e2qq4ngq	245	14	PI4P	PI4P	NNP
cord-018572-e2qq4ngq	245	15	at	at	IN
cord-018572-e2qq4ngq	245	16	the	the	DT
cord-018572-e2qq4ngq	245	17	trans	trans	NNP
cord-018572-e2qq4ngq	245	18	-	-	NNP
cord-018572-e2qq4ngq	245	19	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	245	20	,	,	,
cord-018572-e2qq4ngq	245	21	where	where	WRB
cord-018572-e2qq4ngq	245	22	it	-PRON-	PRP
cord-018572-e2qq4ngq	245	23	is	be	VBZ
cord-018572-e2qq4ngq	245	24	returned	return	VBN
cord-018572-e2qq4ngq	245	25	to	to	IN
cord-018572-e2qq4ngq	245	26	the	the	DT
cord-018572-e2qq4ngq	245	27	ER	ER	NNP
cord-018572-e2qq4ngq	245	28	and	and	CC
cord-018572-e2qq4ngq	245	29	the	the	DT
cord-018572-e2qq4ngq	245	30	phosphate	phosphate	NN
cord-018572-e2qq4ngq	245	31	hydrolysed	hydrolyse	VBN
cord-018572-e2qq4ngq	245	32	by	by	IN
cord-018572-e2qq4ngq	245	33	the	the	DT
cord-018572-e2qq4ngq	245	34	ER	ER	NNP
cord-018572-e2qq4ngq	245	35	-	-	HYPH
cord-018572-e2qq4ngq	245	36	resident	resident	JJ
cord-018572-e2qq4ngq	245	37	PI4P	PI4P	NNP
cord-018572-e2qq4ngq	245	38	phosphatase	phosphatase	NN
cord-018572-e2qq4ngq	245	39	Sac1p	Sac1p	VBZ
cord-018572-e2qq4ngq	245	40	.	.	.
cord-018572-e2qq4ngq	246	1	The	the	DT
cord-018572-e2qq4ngq	246	2	energy	energy	NN
cord-018572-e2qq4ngq	246	3	from	from	IN
cord-018572-e2qq4ngq	246	4	hydrolysis	hydrolysis	NN
cord-018572-e2qq4ngq	246	5	of	of	IN
cord-018572-e2qq4ngq	246	6	phosphate	phosphate	NN
cord-018572-e2qq4ngq	246	7	on	on	IN
cord-018572-e2qq4ngq	246	8	PI4P	PI4P	NNP
cord-018572-e2qq4ngq	246	9	drives	drive	VBZ
cord-018572-e2qq4ngq	246	10	the	the	DT
cord-018572-e2qq4ngq	246	11	transport	transport	NN
cord-018572-e2qq4ngq	246	12	of	of	IN
cord-018572-e2qq4ngq	246	13	sterol	sterol	NN
cord-018572-e2qq4ngq	246	14	up	up	RP
cord-018572-e2qq4ngq	246	15	its	-PRON-	PRP$
cord-018572-e2qq4ngq	246	16	concentration	concentration	NN
cord-018572-e2qq4ngq	246	17	gradient	gradient	NN
cord-018572-e2qq4ngq	246	18	(	(	-LRB-
cord-018572-e2qq4ngq	246	19	Mesmin	Mesmin	NNP
cord-018572-e2qq4ngq	246	20	et	et	NNP
cord-018572-e2qq4ngq	246	21	al	al	NNP
cord-018572-e2qq4ngq	246	22	.	.	NNP
cord-018572-e2qq4ngq	246	23	2013	2013	CD
cord-018572-e2qq4ngq	246	24	)	)	-RRB-
cord-018572-e2qq4ngq	246	25	.	.	.
cord-018572-e2qq4ngq	247	1	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	247	2	is	be	VBZ
cord-018572-e2qq4ngq	247	3	localized	localize	VBN
cord-018572-e2qq4ngq	247	4	to	to	IN
cord-018572-e2qq4ngq	247	5	the	the	DT
cord-018572-e2qq4ngq	247	6	plasma	plasma	NN
cord-018572-e2qq4ngq	247	7	membrane	membrane	NN
cord-018572-e2qq4ngq	247	8	and	and	CC
cord-018572-e2qq4ngq	247	9	regulates	regulate	VBZ
cord-018572-e2qq4ngq	247	10	both	both	CC
cord-018572-e2qq4ngq	247	11	the	the	DT
cord-018572-e2qq4ngq	247	12	cortical	cortical	JJ
cord-018572-e2qq4ngq	247	13	actin	actin	NN
cord-018572-e2qq4ngq	247	14	cytoskeleton	cytoskeleton	NN
cord-018572-e2qq4ngq	247	15	and	and	CC
cord-018572-e2qq4ngq	247	16	endosomal	endosomal	NNP
cord-018572-e2qq4ngq	247	17	membrane	membrane	NN
cord-018572-e2qq4ngq	247	18	recycling	recycling	NN
cord-018572-e2qq4ngq	247	19	.	.	.
cord-018572-e2qq4ngq	248	1	At	at	IN
cord-018572-e2qq4ngq	248	2	the	the	DT
cord-018572-e2qq4ngq	248	3	plasma	plasma	NN
cord-018572-e2qq4ngq	248	4	membrane	membrane	NN
cord-018572-e2qq4ngq	248	5	,	,	,
cord-018572-e2qq4ngq	248	6	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	248	7	modulates	modulate	VBZ
cord-018572-e2qq4ngq	248	8	membrane	membrane	NN
cord-018572-e2qq4ngq	248	9	lipid	lipid	NN
cord-018572-e2qq4ngq	248	10	composition	composition	NN
cord-018572-e2qq4ngq	248	11	through	through	IN
cord-018572-e2qq4ngq	248	12	activation	activation	NN
cord-018572-e2qq4ngq	248	13	of	of	IN
cord-018572-e2qq4ngq	248	14	PI4P	PI4P	NNP
cord-018572-e2qq4ngq	248	15	5-kinase	5-kinase	CD
cord-018572-e2qq4ngq	248	16	(	(	-LRB-
cord-018572-e2qq4ngq	248	17	PIP5	PIP5	NNP
cord-018572-e2qq4ngq	248	18	K	K	NNP
cord-018572-e2qq4ngq	248	19	)	)	-RRB-
cord-018572-e2qq4ngq	248	20	and	and	CC
cord-018572-e2qq4ngq	248	21	PLD	PLD	NNP
cord-018572-e2qq4ngq	248	22	,	,	,
cord-018572-e2qq4ngq	248	23	resulting	result	VBG
cord-018572-e2qq4ngq	248	24	in	in	IN
cord-018572-e2qq4ngq	248	25	production	production	NN
cord-018572-e2qq4ngq	248	26	of	of	IN
cord-018572-e2qq4ngq	248	27	PI(4,5)P	PI(4,5)P	NNP
cord-018572-e2qq4ngq	248	28	2	2	CD
cord-018572-e2qq4ngq	248	29	and	and	CC
cord-018572-e2qq4ngq	248	30	PA	PA	NNP
cord-018572-e2qq4ngq	248	31	.	.	.
cord-018572-e2qq4ngq	249	1	These	these	DT
cord-018572-e2qq4ngq	249	2	phospholipids	phospholipid	NNS
cord-018572-e2qq4ngq	249	3	can	can	MD
cord-018572-e2qq4ngq	249	4	influence	influence	VB
cord-018572-e2qq4ngq	249	5	the	the	DT
cord-018572-e2qq4ngq	249	6	sorting	sorting	NN
cord-018572-e2qq4ngq	249	7	of	of	IN
cord-018572-e2qq4ngq	249	8	membrane	membrane	NN
cord-018572-e2qq4ngq	249	9	proteins	protein	NNS
cord-018572-e2qq4ngq	249	10	within	within	IN
cord-018572-e2qq4ngq	249	11	the	the	DT
cord-018572-e2qq4ngq	249	12	PM	pm	NN
cord-018572-e2qq4ngq	249	13	,	,	,
cord-018572-e2qq4ngq	249	14	and	and	CC
cord-018572-e2qq4ngq	249	15	are	be	VBP
cord-018572-e2qq4ngq	249	16	important	important	JJ
cord-018572-e2qq4ngq	249	17	for	for	IN
cord-018572-e2qq4ngq	249	18	the	the	DT
cord-018572-e2qq4ngq	249	19	formation	formation	NN
cord-018572-e2qq4ngq	249	20	of	of	IN
cord-018572-e2qq4ngq	249	21	clathrin	clathrin	NN
cord-018572-e2qq4ngq	249	22	-	-	HYPH
cord-018572-e2qq4ngq	249	23	coated	coat	VBN
cord-018572-e2qq4ngq	249	24	pits	pit	NNS
cord-018572-e2qq4ngq	249	25	during	during	IN
cord-018572-e2qq4ngq	249	26	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	249	27	.	.	.
cord-018572-e2qq4ngq	250	1	They	-PRON-	PRP
cord-018572-e2qq4ngq	250	2	are	be	VBP
cord-018572-e2qq4ngq	250	3	also	also	RB
cord-018572-e2qq4ngq	250	4	required	require	VBN
cord-018572-e2qq4ngq	250	5	for	for	IN
cord-018572-e2qq4ngq	250	6	the	the	DT
cord-018572-e2qq4ngq	250	7	recruitment	recruitment	NN
cord-018572-e2qq4ngq	250	8	and	and	CC
cord-018572-e2qq4ngq	250	9	activation	activation	NN
cord-018572-e2qq4ngq	250	10	of	of	IN
cord-018572-e2qq4ngq	250	11	Rho	Rho	NNP
cord-018572-e2qq4ngq	250	12	family	family	NN
cord-018572-e2qq4ngq	250	13	G	g	NN
cord-018572-e2qq4ngq	250	14	proteins	protein	NNS
cord-018572-e2qq4ngq	250	15	such	such	JJ
cord-018572-e2qq4ngq	250	16	as	as	IN
cord-018572-e2qq4ngq	250	17	Rac	Rac	NNP
cord-018572-e2qq4ngq	250	18	to	to	TO
cord-018572-e2qq4ngq	250	19	induce	induce	VB
cord-018572-e2qq4ngq	250	20	actin	actin	JJ
cord-018572-e2qq4ngq	250	21	polymerization	polymerization	NN
cord-018572-e2qq4ngq	250	22	.	.	.
cord-018572-e2qq4ngq	251	1	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	251	2	is	be	VBZ
cord-018572-e2qq4ngq	251	3	associated	associate	VBN
cord-018572-e2qq4ngq	251	4	with	with	IN
cord-018572-e2qq4ngq	251	5	endosomal	endosomal	JJ
cord-018572-e2qq4ngq	251	6	membranes	membrane	NNS
cord-018572-e2qq4ngq	251	7	derived	derive	VBN
cord-018572-e2qq4ngq	251	8	from	from	IN
cord-018572-e2qq4ngq	251	9	clathrin	clathrin	NN
cord-018572-e2qq4ngq	251	10	-	-	HYPH
cord-018572-e2qq4ngq	251	11	independent	independent	JJ
cord-018572-e2qq4ngq	251	12	forms	form	NNS
cord-018572-e2qq4ngq	251	13	of	of	IN
cord-018572-e2qq4ngq	251	14	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	251	15	,	,	,
cord-018572-e2qq4ngq	251	16	where	where	WRB
cord-018572-e2qq4ngq	251	17	it	-PRON-	PRP
cord-018572-e2qq4ngq	251	18	functions	function	VBZ
cord-018572-e2qq4ngq	251	19	to	to	TO
cord-018572-e2qq4ngq	251	20	recycle	recycle	VB
cord-018572-e2qq4ngq	251	21	membrane	membrane	NN
cord-018572-e2qq4ngq	251	22	components	component	NNS
cord-018572-e2qq4ngq	251	23	back	back	RB
cord-018572-e2qq4ngq	251	24	to	to	IN
cord-018572-e2qq4ngq	251	25	the	the	DT
cord-018572-e2qq4ngq	251	26	plasma	plasma	NN
cord-018572-e2qq4ngq	251	27	membrane	membrane	NN
cord-018572-e2qq4ngq	251	28	(	(	-LRB-
cord-018572-e2qq4ngq	251	29	Grant	Grant	NNP
cord-018572-e2qq4ngq	251	30	and	and	CC
cord-018572-e2qq4ngq	251	31	Donaldson	Donaldson	NNP
cord-018572-e2qq4ngq	251	32	2009	2009	CD
cord-018572-e2qq4ngq	251	33	)	)	-RRB-
cord-018572-e2qq4ngq	251	34	.	.	.
cord-018572-e2qq4ngq	252	1	Recycling	recycle	VBG
cord-018572-e2qq4ngq	252	2	through	through	IN
cord-018572-e2qq4ngq	252	3	endosomal	endosomal	NNP
cord-018572-e2qq4ngq	252	4	compartments	compartment	NNS
cord-018572-e2qq4ngq	252	5	by	by	IN
cord-018572-e2qq4ngq	252	6	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	252	7	is	be	VBZ
cord-018572-e2qq4ngq	252	8	required	require	VBN
cord-018572-e2qq4ngq	252	9	for	for	IN
cord-018572-e2qq4ngq	252	10	the	the	DT
cord-018572-e2qq4ngq	252	11	polarized	polarized	JJ
cord-018572-e2qq4ngq	252	12	delivery	delivery	NN
cord-018572-e2qq4ngq	252	13	of	of	IN
cord-018572-e2qq4ngq	252	14	Cdc42	Cdc42	NNP
cord-018572-e2qq4ngq	252	15	,	,	,
cord-018572-e2qq4ngq	252	16	Rac	Rac	NNP
cord-018572-e2qq4ngq	252	17	,	,	,
cord-018572-e2qq4ngq	252	18	and	and	CC
cord-018572-e2qq4ngq	252	19	the	the	DT
cord-018572-e2qq4ngq	252	20	Par6	Par6	NNP
cord-018572-e2qq4ngq	252	21	complex	complex	JJ
cord-018572-e2qq4ngq	252	22	to	to	IN
cord-018572-e2qq4ngq	252	23	the	the	DT
cord-018572-e2qq4ngq	252	24	leading	leading	JJ
cord-018572-e2qq4ngq	252	25	edge	edge	NN
cord-018572-e2qq4ngq	252	26	of	of	IN
cord-018572-e2qq4ngq	252	27	migrating	migrate	VBG
cord-018572-e2qq4ngq	252	28	cells	cell	NNS
cord-018572-e2qq4ngq	252	29	(	(	-LRB-
cord-018572-e2qq4ngq	252	30	Osmani	Osmani	NNP
cord-018572-e2qq4ngq	252	31	et	et	NNP
cord-018572-e2qq4ngq	252	32	al	al	NNP
cord-018572-e2qq4ngq	252	33	.	.	NNP
cord-018572-e2qq4ngq	252	34	2010	2010	CD
cord-018572-e2qq4ngq	252	35	)	)	-RRB-
cord-018572-e2qq4ngq	252	36	,	,	,
cord-018572-e2qq4ngq	252	37	and	and	CC
cord-018572-e2qq4ngq	252	38	for	for	IN
cord-018572-e2qq4ngq	252	39	recycling	recycling	NN
cord-018572-e2qq4ngq	252	40	of	of	IN
cord-018572-e2qq4ngq	252	41	proteins	protein	NNS
cord-018572-e2qq4ngq	252	42	involved	involve	VBN
cord-018572-e2qq4ngq	252	43	in	in	IN
cord-018572-e2qq4ngq	252	44	cell	cell	NN
cord-018572-e2qq4ngq	252	45	adhesion	adhesion	NN
cord-018572-e2qq4ngq	252	46	(	(	-LRB-
cord-018572-e2qq4ngq	252	47	Balasubramanian	Balasubramanian	NNP
cord-018572-e2qq4ngq	252	48	et	et	NNP
cord-018572-e2qq4ngq	252	49	al	al	NNP
cord-018572-e2qq4ngq	252	50	.	.	NNP
cord-018572-e2qq4ngq	252	51	2007	2007	CD
cord-018572-e2qq4ngq	252	52	)	)	-RRB-
cord-018572-e2qq4ngq	252	53	.	.	.
cord-018572-e2qq4ngq	253	1	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	253	2	is	be	VBZ
cord-018572-e2qq4ngq	253	3	also	also	RB
cord-018572-e2qq4ngq	253	4	associated	associate	VBN
cord-018572-e2qq4ngq	253	5	with	with	IN
cord-018572-e2qq4ngq	253	6	clathrincoated	clathrincoated	JJ
cord-018572-e2qq4ngq	253	7	vesicles	vesicle	NNS
cord-018572-e2qq4ngq	253	8	,	,	,
cord-018572-e2qq4ngq	253	9	where	where	WRB
cord-018572-e2qq4ngq	253	10	it	-PRON-	PRP
cord-018572-e2qq4ngq	253	11	mediates	mediate	VBZ
cord-018572-e2qq4ngq	253	12	the	the	DT
cord-018572-e2qq4ngq	253	13	rapid	rapid	JJ
cord-018572-e2qq4ngq	253	14	recycling	recycling	NN
cord-018572-e2qq4ngq	253	15	of	of	IN
cord-018572-e2qq4ngq	253	16	transferrin	transferrin	NN
cord-018572-e2qq4ngq	253	17	receptor	receptor	NN
cord-018572-e2qq4ngq	253	18	back	back	RB
cord-018572-e2qq4ngq	253	19	to	to	IN
cord-018572-e2qq4ngq	253	20	the	the	DT
cord-018572-e2qq4ngq	253	21	plasma	plasma	NN
cord-018572-e2qq4ngq	253	22	membrane	membrane	NN
cord-018572-e2qq4ngq	253	23	through	through	IN
cord-018572-e2qq4ngq	253	24	interaction	interaction	NN
cord-018572-e2qq4ngq	253	25	with	with	IN
cord-018572-e2qq4ngq	253	26	the	the	DT
cord-018572-e2qq4ngq	253	27	microtubule	microtubule	JJ
cord-018572-e2qq4ngq	253	28	motor	motor	NN
cord-018572-e2qq4ngq	253	29	adaptor	adaptor	NN
cord-018572-e2qq4ngq	253	30	protein	protein	NN
cord-018572-e2qq4ngq	253	31	JIP4	JIP4	NNP
cord-018572-e2qq4ngq	253	32	after	after	IN
cord-018572-e2qq4ngq	253	33	clathrin	clathrin	NN
cord-018572-e2qq4ngq	253	34	uncoating	uncoating	NN
cord-018572-e2qq4ngq	253	35	(	(	-LRB-
cord-018572-e2qq4ngq	253	36	Montagnac	Montagnac	NNP
cord-018572-e2qq4ngq	253	37	et	et	NNP
cord-018572-e2qq4ngq	253	38	al	al	NNP
cord-018572-e2qq4ngq	253	39	.	.	NNP
cord-018572-e2qq4ngq	253	40	2011	2011	CD
cord-018572-e2qq4ngq	253	41	)	)	-RRB-
cord-018572-e2qq4ngq	253	42	.	.	.
cord-018572-e2qq4ngq	254	1	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	254	2	can	can	MD
cord-018572-e2qq4ngq	254	3	interact	interact	VB
cord-018572-e2qq4ngq	254	4	with	with	IN
cord-018572-e2qq4ngq	254	5	adaptor	adaptor	NN
cord-018572-e2qq4ngq	254	6	protein	protein	NN
cord-018572-e2qq4ngq	254	7	2	2	CD
cord-018572-e2qq4ngq	254	8	(	(	-LRB-
cord-018572-e2qq4ngq	254	9	AP-2	ap-2	NN
cord-018572-e2qq4ngq	254	10	)	)	-RRB-
cord-018572-e2qq4ngq	255	1	(	(	-LRB-
cord-018572-e2qq4ngq	255	2	Paleotti	Paleotti	NNP
cord-018572-e2qq4ngq	255	3	et	et	NNP
cord-018572-e2qq4ngq	255	4	al	al	NNP
cord-018572-e2qq4ngq	255	5	.	.	NNP
cord-018572-e2qq4ngq	255	6	2005	2005	CD
cord-018572-e2qq4ngq	255	7	)	)	-RRB-
cord-018572-e2qq4ngq	256	1	and	and	CC
cord-018572-e2qq4ngq	256	2	with	with	IN
cord-018572-e2qq4ngq	256	3	AP-2	AP-2	NNP
cord-018572-e2qq4ngq	256	4	and	and	CC
cord-018572-e2qq4ngq	256	5	clathrin	clathrin	NN
cord-018572-e2qq4ngq	256	6	during	during	IN
cord-018572-e2qq4ngq	256	7	G	g	NN
cord-018572-e2qq4ngq	256	8	-	-	HYPH
cord-018572-e2qq4ngq	256	9	protein	protein	NN
cord-018572-e2qq4ngq	256	10	coupled	couple	VBN
cord-018572-e2qq4ngq	256	11	receptor	receptor	NN
cord-018572-e2qq4ngq	256	12	cell	cell	NN
cord-018572-e2qq4ngq	256	13	signalling	signal	VBG
cord-018572-e2qq4ngq	256	14	(	(	-LRB-
cord-018572-e2qq4ngq	256	15	Poupart	Poupart	NNP
cord-018572-e2qq4ngq	256	16	et	et	NNP
cord-018572-e2qq4ngq	256	17	al	al	NNP
cord-018572-e2qq4ngq	256	18	.	.	NNP
cord-018572-e2qq4ngq	256	19	2007	2007	CD
cord-018572-e2qq4ngq	256	20	)	)	-RRB-
cord-018572-e2qq4ngq	256	21	.	.	.
cord-018572-e2qq4ngq	257	1	Hence	hence	RB
cord-018572-e2qq4ngq	257	2	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	257	3	has	have	VBZ
cord-018572-e2qq4ngq	257	4	a	a	DT
cord-018572-e2qq4ngq	257	5	general	general	JJ
cord-018572-e2qq4ngq	257	6	function	function	NN
cord-018572-e2qq4ngq	257	7	in	in	IN
cord-018572-e2qq4ngq	257	8	mediating	mediate	VBG
cord-018572-e2qq4ngq	257	9	recycling	recycling	NN
cord-018572-e2qq4ngq	257	10	of	of	IN
cord-018572-e2qq4ngq	257	11	components	component	NNS
cord-018572-e2qq4ngq	257	12	back	back	RB
cord-018572-e2qq4ngq	257	13	to	to	IN
cord-018572-e2qq4ngq	257	14	the	the	DT
cord-018572-e2qq4ngq	257	15	PM	PM	NNP
cord-018572-e2qq4ngq	257	16	after	after	IN
cord-018572-e2qq4ngq	257	17	endocytic	endocytic	JJ
cord-018572-e2qq4ngq	257	18	internalization	internalization	NN
cord-018572-e2qq4ngq	257	19	via	via	IN
cord-018572-e2qq4ngq	257	20	different	different	JJ
cord-018572-e2qq4ngq	257	21	routes	route	NNS
cord-018572-e2qq4ngq	257	22	.	.	.
cord-018572-e2qq4ngq	258	1	Studies	study	NNS
cord-018572-e2qq4ngq	258	2	of	of	IN
cord-018572-e2qq4ngq	258	3	the	the	DT
cord-018572-e2qq4ngq	258	4	Arf6	arf6	JJ
cord-018572-e2qq4ngq	258	5	homologues	homologue	NNS
cord-018572-e2qq4ngq	258	6	in	in	IN
cord-018572-e2qq4ngq	258	7	model	model	NN
cord-018572-e2qq4ngq	258	8	organisms	organism	NNS
cord-018572-e2qq4ngq	258	9	have	have	VBP
cord-018572-e2qq4ngq	258	10	illustrated	illustrate	VBN
cord-018572-e2qq4ngq	258	11	the	the	DT
cord-018572-e2qq4ngq	258	12	evolutionarily	evolutionarily	RB
cord-018572-e2qq4ngq	258	13	conserved	conserved	JJ
cord-018572-e2qq4ngq	258	14	nature	nature	NN
cord-018572-e2qq4ngq	258	15	of	of	IN
cord-018572-e2qq4ngq	258	16	Arf6	arf6	JJ
cord-018572-e2qq4ngq	258	17	function	function	NN
cord-018572-e2qq4ngq	258	18	.	.	.
cord-018572-e2qq4ngq	259	1	Arf3p	Arf3p	NNP
cord-018572-e2qq4ngq	259	2	,	,	,
cord-018572-e2qq4ngq	259	3	the	the	DT
cord-018572-e2qq4ngq	259	4	yeast	yeast	NN
cord-018572-e2qq4ngq	259	5	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	259	6	homologue	homologue	NN
cord-018572-e2qq4ngq	259	7	,	,	,
cord-018572-e2qq4ngq	259	8	affects	affect	VBZ
cord-018572-e2qq4ngq	259	9	polarization	polarization	NN
cord-018572-e2qq4ngq	259	10	events	event	NNS
cord-018572-e2qq4ngq	259	11	such	such	JJ
cord-018572-e2qq4ngq	259	12	as	as	IN
cord-018572-e2qq4ngq	259	13	bud	bud	NN
cord-018572-e2qq4ngq	259	14	site	site	NN
cord-018572-e2qq4ngq	259	15	selection	selection	NN
cord-018572-e2qq4ngq	259	16	in	in	IN
cord-018572-e2qq4ngq	259	17	S.	S.	NNP
cord-018572-e2qq4ngq	259	18	cerevisiae	cerevisiae	NNS
cord-018572-e2qq4ngq	259	19	(	(	-LRB-
cord-018572-e2qq4ngq	259	20	Huang	Huang	NNP
cord-018572-e2qq4ngq	259	21	et	et	NNP
cord-018572-e2qq4ngq	259	22	al	al	NNP
cord-018572-e2qq4ngq	259	23	.	.	NNP
cord-018572-e2qq4ngq	259	24	2003	2003	CD
cord-018572-e2qq4ngq	259	25	)	)	-RRB-
cord-018572-e2qq4ngq	259	26	,	,	,
cord-018572-e2qq4ngq	259	27	and	and	CC
cord-018572-e2qq4ngq	259	28	the	the	DT
cord-018572-e2qq4ngq	259	29	switch	switch	NN
cord-018572-e2qq4ngq	259	30	in	in	IN
cord-018572-e2qq4ngq	259	31	cellular	cellular	JJ
cord-018572-e2qq4ngq	259	32	growth	growth	NN
cord-018572-e2qq4ngq	259	33	from	from	IN
cord-018572-e2qq4ngq	259	34	monopolar	monopolar	JJ
cord-018572-e2qq4ngq	259	35	extension	extension	NN
cord-018572-e2qq4ngq	259	36	to	to	IN
cord-018572-e2qq4ngq	259	37	bipolar	bipolar	JJ
cord-018572-e2qq4ngq	259	38	extension	extension	NN
cord-018572-e2qq4ngq	259	39	in	in	IN
cord-018572-e2qq4ngq	259	40	fission	fission	NN
cord-018572-e2qq4ngq	259	41	yeast	yeast	NN
cord-018572-e2qq4ngq	259	42	(	(	-LRB-
cord-018572-e2qq4ngq	259	43	Fujita	Fujita	NNP
cord-018572-e2qq4ngq	259	44	2008	2008	CD
cord-018572-e2qq4ngq	259	45	)	)	-RRB-
cord-018572-e2qq4ngq	259	46	.	.	.
cord-018572-e2qq4ngq	260	1	Budding	bud	VBG
cord-018572-e2qq4ngq	260	2	yeast	yeast	NN
cord-018572-e2qq4ngq	260	3	Arf3p	Arf3p	NNP
cord-018572-e2qq4ngq	260	4	contributes	contribute	VBZ
cord-018572-e2qq4ngq	260	5	to	to	IN
cord-018572-e2qq4ngq	260	6	PM	PM	NNP
cord-018572-e2qq4ngq	260	7	PI	PI	NNP
cord-018572-e2qq4ngq	260	8	(	(	-LRB-
cord-018572-e2qq4ngq	260	9	4,5)P	4,5)p	CD
cord-018572-e2qq4ngq	260	10	2	2	CD
cord-018572-e2qq4ngq	260	11	levels	level	NNS
cord-018572-e2qq4ngq	260	12	like	like	IN
cord-018572-e2qq4ngq	260	13	its	-PRON-	PRP$
cord-018572-e2qq4ngq	260	14	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	260	15	homologue	homologue	NN
cord-018572-e2qq4ngq	260	16	(	(	-LRB-
cord-018572-e2qq4ngq	260	17	Smaczynska	Smaczynska	NNP
cord-018572-e2qq4ngq	260	18	-	-	HYPH
cord-018572-e2qq4ngq	260	19	de	de	NNP
cord-018572-e2qq4ngq	260	20	Rooij	Rooij	NNP
cord-018572-e2qq4ngq	260	21	et	et	FW
cord-018572-e2qq4ngq	260	22	al	al	NNP
cord-018572-e2qq4ngq	260	23	.	.	NNP
cord-018572-e2qq4ngq	260	24	2008	2008	CD
cord-018572-e2qq4ngq	260	25	)	)	-RRB-
cord-018572-e2qq4ngq	260	26	,	,	,
cord-018572-e2qq4ngq	260	27	and	and	CC
cord-018572-e2qq4ngq	260	28	is	be	VBZ
cord-018572-e2qq4ngq	260	29	involved	involve	VBN
cord-018572-e2qq4ngq	260	30	in	in	IN
cord-018572-e2qq4ngq	260	31	uncoating	uncoating	NN
cord-018572-e2qq4ngq	260	32	of	of	IN
cord-018572-e2qq4ngq	260	33	clathrin	clathrin	NN
cord-018572-e2qq4ngq	260	34	-	-	HYPH
cord-018572-e2qq4ngq	260	35	coated	coat	VBN
cord-018572-e2qq4ngq	260	36	endocytic	endocytic	JJ
cord-018572-e2qq4ngq	260	37	vesicles	vesicle	NNS
cord-018572-e2qq4ngq	260	38	along	along	IN
cord-018572-e2qq4ngq	260	39	with	with	IN
cord-018572-e2qq4ngq	260	40	its	-PRON-	PRP$
cord-018572-e2qq4ngq	260	41	specific	specific	JJ
cord-018572-e2qq4ngq	260	42	GAP	gap	NN
cord-018572-e2qq4ngq	260	43	Gts1p	gts1p	NN
cord-018572-e2qq4ngq	261	1	(	(	-LRB-
cord-018572-e2qq4ngq	261	2	Toret	Toret	NNP
cord-018572-e2qq4ngq	261	3	et	et	NNP
cord-018572-e2qq4ngq	261	4	al	al	NNP
cord-018572-e2qq4ngq	261	5	.	.	NNP
cord-018572-e2qq4ngq	261	6	2008	2008	CD
cord-018572-e2qq4ngq	261	7	)	)	-RRB-
cord-018572-e2qq4ngq	261	8	.	.	.
cord-018572-e2qq4ngq	262	1	In	in	IN
cord-018572-e2qq4ngq	262	2	the	the	DT
cord-018572-e2qq4ngq	262	3	filamentous	filamentous	JJ
cord-018572-e2qq4ngq	262	4	fungus	fungus	NN
cord-018572-e2qq4ngq	262	5	Aspergillus	aspergillus	NN
cord-018572-e2qq4ngq	262	6	nidulans	nidulan	NNS
cord-018572-e2qq4ngq	262	7	,	,	,
cord-018572-e2qq4ngq	262	8	the	the	DT
cord-018572-e2qq4ngq	262	9	Class	Class	NNP
cord-018572-e2qq4ngq	262	10	III	III	NNP
cord-018572-e2qq4ngq	262	11	ArfB	ArfB	NNP
cord-018572-e2qq4ngq	262	12	localizes	localize	VBZ
cord-018572-e2qq4ngq	262	13	to	to	IN
cord-018572-e2qq4ngq	262	14	both	both	CC
cord-018572-e2qq4ngq	262	15	the	the	DT
cord-018572-e2qq4ngq	262	16	plasma	plasma	NN
cord-018572-e2qq4ngq	262	17	membrane	membrane	NN
cord-018572-e2qq4ngq	262	18	and	and	CC
cord-018572-e2qq4ngq	262	19	endomembranes	endomembrane	NNS
cord-018572-e2qq4ngq	262	20	,	,	,
cord-018572-e2qq4ngq	262	21	and	and	CC
cord-018572-e2qq4ngq	262	22	regulates	regulate	VBZ
cord-018572-e2qq4ngq	262	23	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	262	24	and	and	CC
cord-018572-e2qq4ngq	262	25	polarity	polarity	NN
cord-018572-e2qq4ngq	262	26	establishment	establishment	NN
cord-018572-e2qq4ngq	262	27	during	during	IN
cord-018572-e2qq4ngq	262	28	hyphal	hyphal	JJ
cord-018572-e2qq4ngq	262	29	growth	growth	NN
cord-018572-e2qq4ngq	262	30	.	.	.
cord-018572-e2qq4ngq	263	1	Arf6	arf6	VB
cord-018572-e2qq4ngq	263	2	in	in	IN
cord-018572-e2qq4ngq	263	3	Drosophila	Drosophila	NNP
cord-018572-e2qq4ngq	263	4	is	be	VBZ
cord-018572-e2qq4ngq	263	5	also	also	RB
cord-018572-e2qq4ngq	263	6	involved	involve	VBN
cord-018572-e2qq4ngq	263	7	in	in	IN
cord-018572-e2qq4ngq	263	8	endocytic	endocytic	JJ
cord-018572-e2qq4ngq	263	9	recycling	recycling	NN
cord-018572-e2qq4ngq	263	10	,	,	,
cord-018572-e2qq4ngq	263	11	which	which	WDT
cord-018572-e2qq4ngq	263	12	is	be	VBZ
cord-018572-e2qq4ngq	263	13	required	require	VBN
cord-018572-e2qq4ngq	263	14	for	for	IN
cord-018572-e2qq4ngq	263	15	cytokinesis	cytokinesis	NN
cord-018572-e2qq4ngq	263	16	in	in	IN
cord-018572-e2qq4ngq	263	17	spermatocytes	spermatocytes	NNP
cord-018572-e2qq4ngq	263	18	(	(	-LRB-
cord-018572-e2qq4ngq	263	19	Dyer	Dyer	NNP
cord-018572-e2qq4ngq	263	20	et	et	NNP
cord-018572-e2qq4ngq	263	21	al	al	NNP
cord-018572-e2qq4ngq	263	22	.	.	NNP
cord-018572-e2qq4ngq	263	23	2007	2007	CD
cord-018572-e2qq4ngq	263	24	)	)	-RRB-
cord-018572-e2qq4ngq	263	25	.	.	.
cord-018572-e2qq4ngq	264	1	In	in	IN
cord-018572-e2qq4ngq	264	2	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	264	3	cells	cell	NNS
cord-018572-e2qq4ngq	264	4	,	,	,
cord-018572-e2qq4ngq	264	5	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	264	6	is	be	VBZ
cord-018572-e2qq4ngq	264	7	involved	involve	VBN
cord-018572-e2qq4ngq	264	8	in	in	IN
cord-018572-e2qq4ngq	264	9	cytokinesis	cytokinesis	NN
cord-018572-e2qq4ngq	264	10	through	through	IN
cord-018572-e2qq4ngq	264	11	interaction	interaction	NN
cord-018572-e2qq4ngq	264	12	with	with	IN
cord-018572-e2qq4ngq	264	13	JIP4	JIP4	NNP
cord-018572-e2qq4ngq	264	14	)	)	-RRB-
cord-018572-e2qq4ngq	264	15	.	.	.
cord-018572-e2qq4ngq	265	1	The	the	DT
cord-018572-e2qq4ngq	265	2	crystal	crystal	NN
cord-018572-e2qq4ngq	265	3	structure	structure	NN
cord-018572-e2qq4ngq	265	4	of	of	IN
cord-018572-e2qq4ngq	265	5	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	265	6	in	in	IN
cord-018572-e2qq4ngq	265	7	complex	complex	NN
cord-018572-e2qq4ngq	265	8	with	with	IN
cord-018572-e2qq4ngq	265	9	JIP4	JIP4	NNP
cord-018572-e2qq4ngq	265	10	shows	show	VBZ
cord-018572-e2qq4ngq	265	11	that	that	IN
cord-018572-e2qq4ngq	265	12	residues	residue	NNS
cord-018572-e2qq4ngq	265	13	adjacent	adjacent	JJ
cord-018572-e2qq4ngq	265	14	to	to	IN
cord-018572-e2qq4ngq	265	15	the	the	DT
cord-018572-e2qq4ngq	265	16	switch	switch	NN
cord-018572-e2qq4ngq	265	17	regions	region	NNS
cord-018572-e2qq4ngq	265	18	are	be	VBP
cord-018572-e2qq4ngq	265	19	structural	structural	JJ
cord-018572-e2qq4ngq	265	20	determinants	determinant	NNS
cord-018572-e2qq4ngq	265	21	for	for	IN
cord-018572-e2qq4ngq	265	22	the	the	DT
cord-018572-e2qq4ngq	265	23	specific	specific	JJ
cord-018572-e2qq4ngq	265	24	binding	binding	NN
cord-018572-e2qq4ngq	265	25	of	of	IN
cord-018572-e2qq4ngq	265	26	JIP4	JIP4	NNP
cord-018572-e2qq4ngq	265	27	to	to	TO
cord-018572-e2qq4ngq	265	28	Arf6	arf6	VB
cord-018572-e2qq4ngq	265	29	(	(	-LRB-
cord-018572-e2qq4ngq	265	30	Isabet	Isabet	NNP
cord-018572-e2qq4ngq	265	31	et	et	NNP
cord-018572-e2qq4ngq	265	32	al	al	NNP
cord-018572-e2qq4ngq	265	33	.	.	NNP
cord-018572-e2qq4ngq	265	34	2009	2009	CD
cord-018572-e2qq4ngq	265	35	)	)	-RRB-
cord-018572-e2qq4ngq	265	36	.	.	.
cord-018572-e2qq4ngq	266	1	In	in	IN
cord-018572-e2qq4ngq	266	2	mammals	mammal	NNS
cord-018572-e2qq4ngq	266	3	,	,	,
cord-018572-e2qq4ngq	266	4	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	266	5	is	be	VBZ
cord-018572-e2qq4ngq	266	6	not	not	RB
cord-018572-e2qq4ngq	266	7	required	require	VBN
cord-018572-e2qq4ngq	266	8	for	for	IN
cord-018572-e2qq4ngq	266	9	early	early	JJ
cord-018572-e2qq4ngq	266	10	embryonic	embryonic	JJ
cord-018572-e2qq4ngq	266	11	development	development	NN
cord-018572-e2qq4ngq	266	12	,	,	,
cord-018572-e2qq4ngq	266	13	as	as	IN
cord-018572-e2qq4ngq	266	14	demonstrated	demonstrate	VBN
cord-018572-e2qq4ngq	266	15	by	by	IN
cord-018572-e2qq4ngq	266	16	the	the	DT
cord-018572-e2qq4ngq	266	17	fact	fact	NN
cord-018572-e2qq4ngq	266	18	that	that	IN
cord-018572-e2qq4ngq	266	19	homozygous	homozygous	JJ
cord-018572-e2qq4ngq	266	20	knockout	knockout	NN
cord-018572-e2qq4ngq	266	21	mice	mouse	NNS
cord-018572-e2qq4ngq	266	22	can	can	MD
cord-018572-e2qq4ngq	266	23	develop	develop	VB
cord-018572-e2qq4ngq	266	24	to	to	IN
cord-018572-e2qq4ngq	266	25	mid	mid	JJ
cord-018572-e2qq4ngq	266	26	-	-	NN
cord-018572-e2qq4ngq	266	27	gestation	gestation	NN
cord-018572-e2qq4ngq	266	28	or	or	CC
cord-018572-e2qq4ngq	266	29	even	even	RB
cord-018572-e2qq4ngq	266	30	to	to	TO
cord-018572-e2qq4ngq	266	31	birth	birth	VB
cord-018572-e2qq4ngq	266	32	,	,	,
cord-018572-e2qq4ngq	266	33	although	although	IN
cord-018572-e2qq4ngq	266	34	they	-PRON-	PRP
cord-018572-e2qq4ngq	266	35	die	die	VBP
cord-018572-e2qq4ngq	266	36	shortly	shortly	RB
cord-018572-e2qq4ngq	266	37	thereafter	thereafter	RB
cord-018572-e2qq4ngq	267	1	(	(	-LRB-
cord-018572-e2qq4ngq	267	2	Suzuki	Suzuki	NNP
cord-018572-e2qq4ngq	267	3	et	et	FW
cord-018572-e2qq4ngq	267	4	al	al	NNP
cord-018572-e2qq4ngq	267	5	.	.	.
cord-018572-e2qq4ngq	267	6	2006	2006	CD
cord-018572-e2qq4ngq	267	7	)	)	-RRB-
cord-018572-e2qq4ngq	267	8	.	.	.
cord-018572-e2qq4ngq	268	1	Hence	hence	RB
cord-018572-e2qq4ngq	268	2	,	,	,
cord-018572-e2qq4ngq	268	3	the	the	DT
cord-018572-e2qq4ngq	268	4	critical	critical	JJ
cord-018572-e2qq4ngq	268	5	physiological	physiological	JJ
cord-018572-e2qq4ngq	268	6	roles	role	NNS
cord-018572-e2qq4ngq	268	7	of	of	IN
cord-018572-e2qq4ngq	268	8	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	268	9	in	in	IN
cord-018572-e2qq4ngq	268	10	cell	cell	NN
cord-018572-e2qq4ngq	268	11	adhesion	adhesion	NN
cord-018572-e2qq4ngq	268	12	and	and	CC
cord-018572-e2qq4ngq	268	13	cell	cell	NN
cord-018572-e2qq4ngq	268	14	migration	migration	NN
cord-018572-e2qq4ngq	268	15	appear	appear	VBP
cord-018572-e2qq4ngq	268	16	to	to	TO
cord-018572-e2qq4ngq	268	17	be	be	VB
cord-018572-e2qq4ngq	268	18	more	more	RBR
cord-018572-e2qq4ngq	268	19	important	important	JJ
cord-018572-e2qq4ngq	268	20	for	for	IN
cord-018572-e2qq4ngq	268	21	functions	function	NNS
cord-018572-e2qq4ngq	268	22	that	that	WDT
cord-018572-e2qq4ngq	268	23	become	become	VBP
cord-018572-e2qq4ngq	268	24	crucial	crucial	JJ
cord-018572-e2qq4ngq	268	25	late	late	RB
cord-018572-e2qq4ngq	268	26	in	in	IN
cord-018572-e2qq4ngq	268	27	development	development	NN
cord-018572-e2qq4ngq	268	28	of	of	IN
cord-018572-e2qq4ngq	268	29	the	the	DT
cord-018572-e2qq4ngq	268	30	organism	organism	NN
cord-018572-e2qq4ngq	268	31	,	,	,
cord-018572-e2qq4ngq	268	32	such	such	JJ
cord-018572-e2qq4ngq	268	33	as	as	IN
cord-018572-e2qq4ngq	268	34	wound	wind	VBN
cord-018572-e2qq4ngq	268	35	healing	healing	NN
cord-018572-e2qq4ngq	268	36	and	and	CC
cord-018572-e2qq4ngq	268	37	metastasis	metastasis	NN
cord-018572-e2qq4ngq	268	38	,	,	,
cord-018572-e2qq4ngq	268	39	rather	rather	RB
cord-018572-e2qq4ngq	268	40	than	than	IN
cord-018572-e2qq4ngq	268	41	functions	function	NNS
cord-018572-e2qq4ngq	268	42	necessary	necessary	JJ
cord-018572-e2qq4ngq	268	43	for	for	IN
cord-018572-e2qq4ngq	268	44	early	early	JJ
cord-018572-e2qq4ngq	268	45	development	development	NN
cord-018572-e2qq4ngq	268	46	.	.	.
cord-018572-e2qq4ngq	269	1	Detailed	detailed	JJ
cord-018572-e2qq4ngq	269	2	descriptions	description	NNS
cord-018572-e2qq4ngq	269	3	of	of	IN
cord-018572-e2qq4ngq	269	4	the	the	DT
cord-018572-e2qq4ngq	269	5	functions	function	NNS
cord-018572-e2qq4ngq	269	6	of	of	IN
cord-018572-e2qq4ngq	269	7	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	269	8	in	in	IN
cord-018572-e2qq4ngq	269	9	these	these	DT
cord-018572-e2qq4ngq	269	10	processes	process	NNS
cord-018572-e2qq4ngq	269	11	have	have	VBP
cord-018572-e2qq4ngq	269	12	been	be	VBN
cord-018572-e2qq4ngq	269	13	shown	show	VBN
cord-018572-e2qq4ngq	269	14	in	in	IN
cord-018572-e2qq4ngq	269	15	a	a	DT
cord-018572-e2qq4ngq	269	16	large	large	JJ
cord-018572-e2qq4ngq	269	17	number	number	NN
cord-018572-e2qq4ngq	269	18	of	of	IN
cord-018572-e2qq4ngq	269	19	studies	study	NNS
cord-018572-e2qq4ngq	269	20	,	,	,
cord-018572-e2qq4ngq	269	21	and	and	CC
cord-018572-e2qq4ngq	269	22	the	the	DT
cord-018572-e2qq4ngq	269	23	reader	reader	NN
cord-018572-e2qq4ngq	269	24	is	be	VBZ
cord-018572-e2qq4ngq	269	25	referred	refer	VBN
cord-018572-e2qq4ngq	269	26	to	to	IN
cord-018572-e2qq4ngq	269	27	recent	recent	JJ
cord-018572-e2qq4ngq	269	28	excellent	excellent	JJ
cord-018572-e2qq4ngq	269	29	reviews	review	NNS
cord-018572-e2qq4ngq	269	30	on	on	IN
cord-018572-e2qq4ngq	269	31	the	the	DT
cord-018572-e2qq4ngq	269	32	subject	subject	NN
cord-018572-e2qq4ngq	269	33	(	(	-LRB-
cord-018572-e2qq4ngq	269	34	D'Souza	D'Souza	NNP
cord-018572-e2qq4ngq	269	35	-	-	HYPH
cord-018572-e2qq4ngq	269	36	Schorey	Schorey	NNP
cord-018572-e2qq4ngq	269	37	and	and	CC
cord-018572-e2qq4ngq	269	38	Chavrier	Chavrier	NNP
cord-018572-e2qq4ngq	269	39	2006	2006	CD
cord-018572-e2qq4ngq	269	40	;	;	:
cord-018572-e2qq4ngq	269	41	Schweitzer	Schweitzer	NNP
cord-018572-e2qq4ngq	269	42	et	et	NNP
cord-018572-e2qq4ngq	269	43	al	al	NNP
cord-018572-e2qq4ngq	269	44	.	.	NNP
cord-018572-e2qq4ngq	269	45	2011	2011	CD
cord-018572-e2qq4ngq	269	46	)	)	-RRB-
cord-018572-e2qq4ngq	269	47	.	.	.
cord-018572-e2qq4ngq	270	1	Of	of	IN
cord-018572-e2qq4ngq	270	2	the	the	DT
cord-018572-e2qq4ngq	270	3	seven	seven	CD
cord-018572-e2qq4ngq	270	4	subfamilies	subfamily	NNS
cord-018572-e2qq4ngq	270	5	of	of	IN
cord-018572-e2qq4ngq	270	6	Arf	Arf	NNP
cord-018572-e2qq4ngq	270	7	GEFs	gefs	NN
cord-018572-e2qq4ngq	270	8	in	in	IN
cord-018572-e2qq4ngq	270	9	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	270	10	cells	cell	NNS
cord-018572-e2qq4ngq	270	11	,	,	,
cord-018572-e2qq4ngq	270	12	probably	probably	RB
cord-018572-e2qq4ngq	270	13	the	the	DT
cord-018572-e2qq4ngq	270	14	most	most	RBS
cord-018572-e2qq4ngq	270	15	intensively	intensively	RB
cord-018572-e2qq4ngq	270	16	studied	study	VBN
cord-018572-e2qq4ngq	270	17	are	be	VBP
cord-018572-e2qq4ngq	270	18	the	the	DT
cord-018572-e2qq4ngq	270	19	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	270	20	/	/	SYM
cord-018572-e2qq4ngq	270	21	Arno	Arno	NNP
cord-018572-e2qq4ngq	270	22	proteins	protein	NNS
cord-018572-e2qq4ngq	270	23	.	.	.
cord-018572-e2qq4ngq	271	1	This	this	DT
cord-018572-e2qq4ngq	271	2	subfamily	subfamily	NN
cord-018572-e2qq4ngq	271	3	was	be	VBD
cord-018572-e2qq4ngq	271	4	the	the	DT
cord-018572-e2qq4ngq	271	5	first	first	JJ
cord-018572-e2qq4ngq	271	6	one	one	CD
cord-018572-e2qq4ngq	271	7	to	to	TO
cord-018572-e2qq4ngq	271	8	be	be	VB
cord-018572-e2qq4ngq	271	9	identified	identify	VBN
cord-018572-e2qq4ngq	271	10	in	in	IN
cord-018572-e2qq4ngq	271	11	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	271	12	cells	cell	NNS
cord-018572-e2qq4ngq	271	13	(	(	-LRB-
cord-018572-e2qq4ngq	271	14	Chardin	Chardin	NNP
cord-018572-e2qq4ngq	271	15	et	et	NNP
cord-018572-e2qq4ngq	271	16	al	al	NNP
cord-018572-e2qq4ngq	271	17	.	.	.
cord-018572-e2qq4ngq	271	18	1996	1996	CD
cord-018572-e2qq4ngq	271	19	)	)	-RRB-
cord-018572-e2qq4ngq	271	20	,	,	,
cord-018572-e2qq4ngq	271	21	and	and	CC
cord-018572-e2qq4ngq	271	22	in	in	IN
cord-018572-e2qq4ngq	271	23	addition	addition	NN
cord-018572-e2qq4ngq	271	24	to	to	IN
cord-018572-e2qq4ngq	271	25	a	a	DT
cord-018572-e2qq4ngq	271	26	wide	wide	JJ
cord-018572-e2qq4ngq	271	27	range	range	NN
cord-018572-e2qq4ngq	271	28	of	of	IN
cord-018572-e2qq4ngq	271	29	crucial	crucial	JJ
cord-018572-e2qq4ngq	271	30	physiological	physiological	JJ
cord-018572-e2qq4ngq	271	31	functions	function	NNS
cord-018572-e2qq4ngq	271	32	,	,	,
cord-018572-e2qq4ngq	271	33	its	-PRON-	PRP$
cord-018572-e2qq4ngq	271	34	members	member	NNS
cord-018572-e2qq4ngq	271	35	have	have	VBP
cord-018572-e2qq4ngq	271	36	proved	prove	VBN
cord-018572-e2qq4ngq	271	37	to	to	TO
cord-018572-e2qq4ngq	271	38	be	be	VB
cord-018572-e2qq4ngq	271	39	highly	highly	RB
cord-018572-e2qq4ngq	271	40	amenable	amenable	JJ
cord-018572-e2qq4ngq	271	41	to	to	IN
cord-018572-e2qq4ngq	271	42	biochemical	biochemical	JJ
cord-018572-e2qq4ngq	271	43	and	and	CC
cord-018572-e2qq4ngq	271	44	structural	structural	JJ
cord-018572-e2qq4ngq	271	45	characterization	characterization	NN
cord-018572-e2qq4ngq	271	46	.	.	.
cord-018572-e2qq4ngq	272	1	The	the	DT
cord-018572-e2qq4ngq	272	2	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	272	3	/	/	SYM
cord-018572-e2qq4ngq	272	4	Arno	Arno	NNP
cord-018572-e2qq4ngq	272	5	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	272	6	function	function	NN
cord-018572-e2qq4ngq	272	7	in	in	IN
cord-018572-e2qq4ngq	272	8	plasma	plasma	NN
cord-018572-e2qq4ngq	272	9	membrane	membrane	NN
cord-018572-e2qq4ngq	272	10	-	-	HYPH
cord-018572-e2qq4ngq	272	11	endosomal	endosomal	VBG
cord-018572-e2qq4ngq	272	12	membrane	membrane	NN
cord-018572-e2qq4ngq	272	13	trafficking	trafficking	NN
cord-018572-e2qq4ngq	272	14	routes	route	NNS
cord-018572-e2qq4ngq	272	15	,	,	,
cord-018572-e2qq4ngq	272	16	in	in	IN
cord-018572-e2qq4ngq	272	17	cytoskeleton	cytoskeleton	NN
cord-018572-e2qq4ngq	272	18	regulation	regulation	NN
cord-018572-e2qq4ngq	272	19	,	,	,
cord-018572-e2qq4ngq	272	20	as	as	RB
cord-018572-e2qq4ngq	272	21	well	well	RB
cord-018572-e2qq4ngq	272	22	as	as	IN
cord-018572-e2qq4ngq	272	23	in	in	IN
cord-018572-e2qq4ngq	272	24	signal	signal	NN
cord-018572-e2qq4ngq	272	25	transduction	transduction	NN
cord-018572-e2qq4ngq	272	26	pathways	pathway	NNS
cord-018572-e2qq4ngq	272	27	important	important	JJ
cord-018572-e2qq4ngq	272	28	for	for	IN
cord-018572-e2qq4ngq	272	29	cell	cell	NN
cord-018572-e2qq4ngq	272	30	proliferation	proliferation	NN
cord-018572-e2qq4ngq	272	31	,	,	,
cord-018572-e2qq4ngq	272	32	immune	immune	JJ
cord-018572-e2qq4ngq	272	33	response	response	NN
cord-018572-e2qq4ngq	272	34	,	,	,
cord-018572-e2qq4ngq	272	35	and	and	CC
cord-018572-e2qq4ngq	272	36	growth	growth	NN
cord-018572-e2qq4ngq	272	37	control	control	NN
cord-018572-e2qq4ngq	272	38	(	(	-LRB-
cord-018572-e2qq4ngq	272	39	Casanova	Casanova	NNP
cord-018572-e2qq4ngq	272	40	2007	2007	CD
cord-018572-e2qq4ngq	272	41	;	;	:
cord-018572-e2qq4ngq	272	42	Kolanus	Kolanus	NNP
cord-018572-e2qq4ngq	272	43	2007	2007	CD
cord-018572-e2qq4ngq	272	44	)	)	-RRB-
cord-018572-e2qq4ngq	272	45	.	.	.
cord-018572-e2qq4ngq	273	1	Members	member	NNS
cord-018572-e2qq4ngq	273	2	of	of	IN
cord-018572-e2qq4ngq	273	3	this	this	DT
cord-018572-e2qq4ngq	273	4	GEF	GEF	NNP
cord-018572-e2qq4ngq	273	5	family	family	NN
cord-018572-e2qq4ngq	273	6	can	can	MD
cord-018572-e2qq4ngq	273	7	catalyse	catalyse	VB
cord-018572-e2qq4ngq	273	8	exchange	exchange	NN
cord-018572-e2qq4ngq	273	9	on	on	IN
cord-018572-e2qq4ngq	273	10	both	both	CC
cord-018572-e2qq4ngq	273	11	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	273	12	and	and	CC
cord-018572-e2qq4ngq	273	13	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	273	14	in	in	IN
cord-018572-e2qq4ngq	273	15	vitro	vitro	FW
cord-018572-e2qq4ngq	273	16	and	and	CC
cord-018572-e2qq4ngq	273	17	in	in	IN
cord-018572-e2qq4ngq	273	18	cells	cell	NNS
cord-018572-e2qq4ngq	273	19	,	,	,
cord-018572-e2qq4ngq	273	20	although	although	IN
cord-018572-e2qq4ngq	273	21	in	in	IN
cord-018572-e2qq4ngq	273	22	vitro	vitro	FW
cord-018572-e2qq4ngq	273	23	they	-PRON-	PRP
cord-018572-e2qq4ngq	273	24	are	be	VBP
cord-018572-e2qq4ngq	273	25	more	more	RBR
cord-018572-e2qq4ngq	273	26	efficient	efficient	JJ
cord-018572-e2qq4ngq	273	27	GEFs	gef	NNS
cord-018572-e2qq4ngq	273	28	for	for	IN
cord-018572-e2qq4ngq	273	29	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	273	30	(	(	-LRB-
cord-018572-e2qq4ngq	273	31	Casanova	Casanova	NNP
cord-018572-e2qq4ngq	273	32	2007	2007	CD
cord-018572-e2qq4ngq	273	33	;	;	:
cord-018572-e2qq4ngq	274	1	Macia	Macia	NNP
cord-018572-e2qq4ngq	274	2	et	et	NNP
cord-018572-e2qq4ngq	274	3	al	al	NNP
cord-018572-e2qq4ngq	274	4	.	.	NNP
cord-018572-e2qq4ngq	274	5	2001	2001	CD
cord-018572-e2qq4ngq	274	6	)	)	-RRB-
cord-018572-e2qq4ngq	274	7	.	.	.
cord-018572-e2qq4ngq	275	1	Cytohesin	Cytohesin	NNP
cord-018572-e2qq4ngq	275	2	activation	activation	NN
cord-018572-e2qq4ngq	275	3	is	be	VBZ
cord-018572-e2qq4ngq	275	4	spatially	spatially	RB
cord-018572-e2qq4ngq	275	5	regulated	regulate	VBN
cord-018572-e2qq4ngq	275	6	through	through	IN
cord-018572-e2qq4ngq	275	7	relief	relief	NN
cord-018572-e2qq4ngq	275	8	of	of	IN
cord-018572-e2qq4ngq	275	9	autoinhibition	autoinhibition	NN
cord-018572-e2qq4ngq	275	10	,	,	,
cord-018572-e2qq4ngq	275	11	positive	positive	JJ
cord-018572-e2qq4ngq	275	12	feedback	feedback	NN
cord-018572-e2qq4ngq	275	13	loops	loop	NNS
cord-018572-e2qq4ngq	275	14	,	,	,
cord-018572-e2qq4ngq	275	15	and	and	CC
cord-018572-e2qq4ngq	275	16	activation	activation	NN
cord-018572-e2qq4ngq	275	17	cascades	cascade	NNS
cord-018572-e2qq4ngq	275	18	.	.	.
cord-018572-e2qq4ngq	276	1	At	at	IN
cord-018572-e2qq4ngq	276	2	the	the	DT
cord-018572-e2qq4ngq	276	3	plasma	plasma	NN
cord-018572-e2qq4ngq	276	4	membrane	membrane	NN
cord-018572-e2qq4ngq	276	5	,	,	,
cord-018572-e2qq4ngq	276	6	the	the	DT
cord-018572-e2qq4ngq	276	7	PH	PH	NNP
cord-018572-e2qq4ngq	276	8	domains	domain	NNS
cord-018572-e2qq4ngq	276	9	of	of	IN
cord-018572-e2qq4ngq	276	10	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	276	11	family	family	NN
cord-018572-e2qq4ngq	276	12	members	member	NNS
cord-018572-e2qq4ngq	276	13	interact	interact	VBP
cord-018572-e2qq4ngq	276	14	with	with	IN
cord-018572-e2qq4ngq	276	15	PM	pm	NN
cord-018572-e2qq4ngq	276	16	-	-	HYPH
cord-018572-e2qq4ngq	276	17	specific	specific	JJ
cord-018572-e2qq4ngq	276	18	phosphoinositides	phosphoinositide	NNS
cord-018572-e2qq4ngq	276	19	and	and	CC
cord-018572-e2qq4ngq	276	20	with	with	IN
cord-018572-e2qq4ngq	276	21	the	the	DT
cord-018572-e2qq4ngq	276	22	GTP	GTP	NNP
cord-018572-e2qq4ngq	276	23	-	-	HYPH
cord-018572-e2qq4ngq	276	24	bound	bind	VBN
cord-018572-e2qq4ngq	276	25	forms	form	NNS
cord-018572-e2qq4ngq	276	26	of	of	IN
cord-018572-e2qq4ngq	276	27	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	276	28	(	(	-LRB-
cord-018572-e2qq4ngq	276	29	Cohen	Cohen	NNP
cord-018572-e2qq4ngq	276	30	et	et	NNP
cord-018572-e2qq4ngq	276	31	al	al	NNP
cord-018572-e2qq4ngq	276	32	.	.	NNP
cord-018572-e2qq4ngq	276	33	2007	2007	CD
cord-018572-e2qq4ngq	276	34	)	)	-RRB-
cord-018572-e2qq4ngq	277	1	and	and	CC
cord-018572-e2qq4ngq	277	2	Arl4	Arl4	NNP
cord-018572-e2qq4ngq	277	3	(	(	-LRB-
cord-018572-e2qq4ngq	277	4	Hofmann	Hofmann	NNP
cord-018572-e2qq4ngq	277	5	et	et	NNP
cord-018572-e2qq4ngq	277	6	al	al	NNP
cord-018572-e2qq4ngq	277	7	.	.	NNP
cord-018572-e2qq4ngq	277	8	2007	2007	CD
cord-018572-e2qq4ngq	277	9	;	;	:
cord-018572-e2qq4ngq	277	10	Li	Li	NNP
cord-018572-e2qq4ngq	277	11	et	et	NNP
cord-018572-e2qq4ngq	277	12	al	al	NNP
cord-018572-e2qq4ngq	277	13	.	.	NNP
cord-018572-e2qq4ngq	277	14	2007	2007	CD
cord-018572-e2qq4ngq	277	15	)	)	-RRB-
cord-018572-e2qq4ngq	277	16	,	,	,
cord-018572-e2qq4ngq	277	17	leading	lead	VBG
cord-018572-e2qq4ngq	277	18	to	to	IN
cord-018572-e2qq4ngq	277	19	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	277	20	recruitment	recruitment	NNP
cord-018572-e2qq4ngq	277	21	and	and	CC
cord-018572-e2qq4ngq	277	22	further	further	JJ
cord-018572-e2qq4ngq	277	23	activation	activation	NN
cord-018572-e2qq4ngq	277	24	of	of	IN
cord-018572-e2qq4ngq	277	25	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	277	26	or	or	CC
cord-018572-e2qq4ngq	277	27	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	277	28	at	at	IN
cord-018572-e2qq4ngq	277	29	the	the	DT
cord-018572-e2qq4ngq	277	30	plasma	plasma	NN
cord-018572-e2qq4ngq	277	31	membrane	membrane	NN
cord-018572-e2qq4ngq	277	32	.	.	.
cord-018572-e2qq4ngq	278	1	A	a	DT
cord-018572-e2qq4ngq	278	2	crystal	crystal	JJ
cord-018572-e2qq4ngq	278	3	structure	structure	NN
cord-018572-e2qq4ngq	278	4	of	of	IN
cord-018572-e2qq4ngq	278	5	the	the	DT
cord-018572-e2qq4ngq	278	6	autoinhibited	autoinhibite	VBN
cord-018572-e2qq4ngq	278	7	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	278	8	domain	domain	NN
cord-018572-e2qq4ngq	278	9	in	in	IN
cord-018572-e2qq4ngq	278	10	tandem	tandem	NN
cord-018572-e2qq4ngq	278	11	with	with	IN
cord-018572-e2qq4ngq	278	12	the	the	DT
cord-018572-e2qq4ngq	278	13	PH	PH	NNP
cord-018572-e2qq4ngq	278	14	domain	domain	NN
cord-018572-e2qq4ngq	278	15	of	of	IN
cord-018572-e2qq4ngq	278	16	cytohesin3/	cytohesin3/	CD
cord-018572-e2qq4ngq	279	1	Grp1	Grp1	NNP
cord-018572-e2qq4ngq	279	2	revealed	reveal	VBD
cord-018572-e2qq4ngq	279	3	that	that	IN
cord-018572-e2qq4ngq	279	4	the	the	DT
cord-018572-e2qq4ngq	279	5	C	C	NNP
cord-018572-e2qq4ngq	279	6	-	-	HYPH
cord-018572-e2qq4ngq	279	7	terminal	terminal	NN
cord-018572-e2qq4ngq	279	8	helix	helix	NN
cord-018572-e2qq4ngq	279	9	that	that	WDT
cord-018572-e2qq4ngq	279	10	follows	follow	VBZ
cord-018572-e2qq4ngq	279	11	the	the	DT
cord-018572-e2qq4ngq	279	12	PH	PH	NNP
cord-018572-e2qq4ngq	279	13	domain	domain	NN
cord-018572-e2qq4ngq	279	14	and	and	CC
cord-018572-e2qq4ngq	279	15	the	the	DT
cord-018572-e2qq4ngq	279	16	linker	linker	NN
cord-018572-e2qq4ngq	279	17	between	between	IN
cord-018572-e2qq4ngq	279	18	the	the	DT
cord-018572-e2qq4ngq	279	19	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	279	20	and	and	CC
cord-018572-e2qq4ngq	279	21	PH	PH	NNP
cord-018572-e2qq4ngq	279	22	domains	domain	NNS
cord-018572-e2qq4ngq	279	23	block	block	VBP
cord-018572-e2qq4ngq	279	24	the	the	DT
cord-018572-e2qq4ngq	279	25	catalytic	catalytic	JJ
cord-018572-e2qq4ngq	279	26	site	site	NN
cord-018572-e2qq4ngq	279	27	(	(	-LRB-
cord-018572-e2qq4ngq	279	28	DiNitto	DiNitto	NNP
cord-018572-e2qq4ngq	279	29	et	et	NNP
cord-018572-e2qq4ngq	279	30	al	al	NNP
cord-018572-e2qq4ngq	279	31	.	.	NNP
cord-018572-e2qq4ngq	279	32	2007	2007	CD
cord-018572-e2qq4ngq	279	33	)	)	-RRB-
cord-018572-e2qq4ngq	279	34	.	.	.
cord-018572-e2qq4ngq	280	1	Interaction	interaction	NN
cord-018572-e2qq4ngq	280	2	of	of	IN
cord-018572-e2qq4ngq	280	3	the	the	DT
cord-018572-e2qq4ngq	280	4	PH	PH	NNP
cord-018572-e2qq4ngq	280	5	domain	domain	NN
cord-018572-e2qq4ngq	280	6	with	with	IN
cord-018572-e2qq4ngq	280	7	Arf6-GTP	arf6-gtp	NN
cord-018572-e2qq4ngq	280	8	and	and	CC
cord-018572-e2qq4ngq	280	9	phosphoinositides	phosphoinositide	NNS
cord-018572-e2qq4ngq	280	10	,	,	,
cord-018572-e2qq4ngq	280	11	either	either	CC
cord-018572-e2qq4ngq	280	12	PI(4,5)P	PI(4,5)P	NNP
cord-018572-e2qq4ngq	280	13	2	2	CD
cord-018572-e2qq4ngq	280	14	or	or	CC
cord-018572-e2qq4ngq	280	15	PI(3,4,5)P	PI(3,4,5)P	NNP
cord-018572-e2qq4ngq	280	16	3	3	CD
cord-018572-e2qq4ngq	280	17	,	,	,
cord-018572-e2qq4ngq	280	18	as	as	RB
cord-018572-e2qq4ngq	280	19	well	well	RB
cord-018572-e2qq4ngq	280	20	as	as	IN
cord-018572-e2qq4ngq	280	21	the	the	DT
cord-018572-e2qq4ngq	280	22	interaction	interaction	NN
cord-018572-e2qq4ngq	280	23	of	of	IN
cord-018572-e2qq4ngq	280	24	the	the	DT
cord-018572-e2qq4ngq	280	25	polybasic	polybasic	NNP
cord-018572-e2qq4ngq	280	26	C	C	NNP
cord-018572-e2qq4ngq	280	27	-	-	HYPH
cord-018572-e2qq4ngq	280	28	terminus	terminus	NN
cord-018572-e2qq4ngq	280	29	of	of	IN
cord-018572-e2qq4ngq	280	30	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	280	31	/	/	SYM
cord-018572-e2qq4ngq	280	32	Arno	Arno	NNP
cord-018572-e2qq4ngq	280	33	with	with	IN
cord-018572-e2qq4ngq	280	34	acidic	acidic	JJ
cord-018572-e2qq4ngq	280	35	phospholipids	phospholipid	NNS
cord-018572-e2qq4ngq	280	36	,	,	,
cord-018572-e2qq4ngq	280	37	all	all	DT
cord-018572-e2qq4ngq	280	38	contribute	contribute	VBP
cord-018572-e2qq4ngq	280	39	to	to	IN
cord-018572-e2qq4ngq	280	40	relieving	relieve	VBG
cord-018572-e2qq4ngq	280	41	this	this	DT
cord-018572-e2qq4ngq	280	42	autoinhibition	autoinhibition	NN
cord-018572-e2qq4ngq	280	43	(	(	-LRB-
cord-018572-e2qq4ngq	280	44	DiNitto	DiNitto	NNP
cord-018572-e2qq4ngq	280	45	et	et	NNP
cord-018572-e2qq4ngq	280	46	al	al	NNP
cord-018572-e2qq4ngq	280	47	.	.	NNP
cord-018572-e2qq4ngq	280	48	2007	2007	CD
cord-018572-e2qq4ngq	280	49	)	)	-RRB-
cord-018572-e2qq4ngq	280	50	.	.	.
cord-018572-e2qq4ngq	281	1	Reconstitution	reconstitution	NN
cord-018572-e2qq4ngq	281	2	of	of	IN
cord-018572-e2qq4ngq	281	3	the	the	DT
cord-018572-e2qq4ngq	281	4	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	281	5	/	/	SYM
cord-018572-e2qq4ngq	281	6	Arno	Arno	NNP
cord-018572-e2qq4ngq	281	7	exchange	exchange	NN
cord-018572-e2qq4ngq	281	8	assay	assay	NN
cord-018572-e2qq4ngq	281	9	on	on	IN
cord-018572-e2qq4ngq	281	10	liposomes	liposome	NNS
cord-018572-e2qq4ngq	281	11	,	,	,
cord-018572-e2qq4ngq	281	12	in	in	IN
cord-018572-e2qq4ngq	281	13	the	the	DT
cord-018572-e2qq4ngq	281	14	presence	presence	NN
cord-018572-e2qq4ngq	281	15	of	of	IN
cord-018572-e2qq4ngq	281	16	both	both	CC
cord-018572-e2qq4ngq	281	17	activating	activate	VBG
cord-018572-e2qq4ngq	281	18	Arf6-GTP	arf6-gtp	NN
cord-018572-e2qq4ngq	281	19	and	and	CC
cord-018572-e2qq4ngq	281	20	substrate	substrate	NN
cord-018572-e2qq4ngq	281	21	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	281	22	,	,	,
cord-018572-e2qq4ngq	281	23	revealed	reveal	VBD
cord-018572-e2qq4ngq	281	24	that	that	IN
cord-018572-e2qq4ngq	281	25	mutations	mutation	NNS
cord-018572-e2qq4ngq	281	26	in	in	IN
cord-018572-e2qq4ngq	281	27	the	the	DT
cord-018572-e2qq4ngq	281	28	PH	PH	NNP
cord-018572-e2qq4ngq	281	29	domain	domain	NN
cord-018572-e2qq4ngq	281	30	of	of	IN
cord-018572-e2qq4ngq	281	31	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	281	32	/	/	SYM
cord-018572-e2qq4ngq	281	33	Arno	Arno	NNP
cord-018572-e2qq4ngq	281	34	that	that	WDT
cord-018572-e2qq4ngq	281	35	abolished	abolish	VBD
cord-018572-e2qq4ngq	281	36	interaction	interaction	NN
cord-018572-e2qq4ngq	281	37	with	with	IN
cord-018572-e2qq4ngq	281	38	Arf6-GTP	arf6-gtp	NN
cord-018572-e2qq4ngq	281	39	were	be	VBD
cord-018572-e2qq4ngq	281	40	completely	completely	RB
cord-018572-e2qq4ngq	281	41	inactive	inactive	JJ
cord-018572-e2qq4ngq	282	1	(	(	-LRB-
cord-018572-e2qq4ngq	282	2	Stalder	Stalder	NNP
cord-018572-e2qq4ngq	282	3	et	et	FW
cord-018572-e2qq4ngq	282	4	al	al	NNP
cord-018572-e2qq4ngq	282	5	.	.	NNP
cord-018572-e2qq4ngq	282	6	2011	2011	CD
cord-018572-e2qq4ngq	282	7	)	)	-RRB-
cord-018572-e2qq4ngq	282	8	.	.	.
cord-018572-e2qq4ngq	283	1	Hence	hence	RB
cord-018572-e2qq4ngq	283	2	interaction	interaction	NN
cord-018572-e2qq4ngq	283	3	of	of	IN
cord-018572-e2qq4ngq	283	4	the	the	DT
cord-018572-e2qq4ngq	283	5	PH	PH	NNP
cord-018572-e2qq4ngq	283	6	domain	domain	NN
cord-018572-e2qq4ngq	283	7	with	with	IN
cord-018572-e2qq4ngq	283	8	an	an	DT
cord-018572-e2qq4ngq	283	9	activating	activate	VBG
cord-018572-e2qq4ngq	283	10	Arf	Arf	NNP
cord-018572-e2qq4ngq	283	11	protein	protein	NN
cord-018572-e2qq4ngq	283	12	is	be	VBZ
cord-018572-e2qq4ngq	283	13	an	an	DT
cord-018572-e2qq4ngq	283	14	absolute	absolute	JJ
cord-018572-e2qq4ngq	283	15	requirement	requirement	NN
cord-018572-e2qq4ngq	283	16	for	for	IN
cord-018572-e2qq4ngq	283	17	relief	relief	NN
cord-018572-e2qq4ngq	283	18	of	of	IN
cord-018572-e2qq4ngq	283	19	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	283	20	/	/	SYM
cord-018572-e2qq4ngq	283	21	Arno	Arno	NNP
cord-018572-e2qq4ngq	283	22	autoinhibition	autoinhibition	NN
cord-018572-e2qq4ngq	283	23	on	on	IN
cord-018572-e2qq4ngq	283	24	membranes	membrane	NNS
cord-018572-e2qq4ngq	283	25	.	.	.
cord-018572-e2qq4ngq	284	1	A	a	DT
cord-018572-e2qq4ngq	284	2	recent	recent	JJ
cord-018572-e2qq4ngq	284	3	structure	structure	NN
cord-018572-e2qq4ngq	284	4	of	of	IN
cord-018572-e2qq4ngq	284	5	the	the	DT
cord-018572-e2qq4ngq	284	6	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	284	7	and	and	CC
cord-018572-e2qq4ngq	284	8	PH	PH	NNP
cord-018572-e2qq4ngq	284	9	domains	domain	NNS
cord-018572-e2qq4ngq	284	10	of	of	IN
cord-018572-e2qq4ngq	284	11	Arno	Arno	NNP
cord-018572-e2qq4ngq	284	12	in	in	IN
cord-018572-e2qq4ngq	284	13	complex	complex	NN
cord-018572-e2qq4ngq	284	14	with	with	IN
cord-018572-e2qq4ngq	284	15	Arf6-GTP	arf6-gtp	NN
cord-018572-e2qq4ngq	284	16	,	,	,
cord-018572-e2qq4ngq	284	17	when	when	WRB
cord-018572-e2qq4ngq	284	18	compared	compare	VBN
cord-018572-e2qq4ngq	284	19	to	to	IN
cord-018572-e2qq4ngq	284	20	the	the	DT
cord-018572-e2qq4ngq	284	21	autoinhibited	autoinhibite	VBN
cord-018572-e2qq4ngq	284	22	structure	structure	NN
cord-018572-e2qq4ngq	284	23	,	,	,
cord-018572-e2qq4ngq	284	24	reveals	reveal	VBZ
cord-018572-e2qq4ngq	284	25	a	a	DT
cord-018572-e2qq4ngq	284	26	large	large	JJ
cord-018572-e2qq4ngq	284	27	conformational	conformational	JJ
cord-018572-e2qq4ngq	284	28	change	change	NN
cord-018572-e2qq4ngq	284	29	upon	upon	IN
cord-018572-e2qq4ngq	284	30	Arf6-GTP	arf6-gtp	NN
cord-018572-e2qq4ngq	284	31	binding	binding	NN
cord-018572-e2qq4ngq	284	32	.	.	.
cord-018572-e2qq4ngq	285	1	Binding	bind	VBG
cord-018572-e2qq4ngq	285	2	of	of	IN
cord-018572-e2qq4ngq	285	3	Arf6-GTP	arf6-gtp	NN
cord-018572-e2qq4ngq	285	4	creates	create	VBZ
cord-018572-e2qq4ngq	285	5	grooves	groove	NNS
cord-018572-e2qq4ngq	285	6	at	at	IN
cord-018572-e2qq4ngq	285	7	the	the	DT
cord-018572-e2qq4ngq	285	8	Arf6-PH	Arf6-PH	NNP
cord-018572-e2qq4ngq	285	9	domain	domain	NN
cord-018572-e2qq4ngq	285	10	interface	interface	NN
cord-018572-e2qq4ngq	285	11	into	into	IN
cord-018572-e2qq4ngq	285	12	which	which	WDT
cord-018572-e2qq4ngq	285	13	the	the	DT
cord-018572-e2qq4ngq	285	14	autoinhibitory	autoinhibitory	JJ
cord-018572-e2qq4ngq	285	15	elements	element	NNS
cord-018572-e2qq4ngq	285	16	bind	bind	VBP
cord-018572-e2qq4ngq	285	17	,	,	,
cord-018572-e2qq4ngq	285	18	thus	thus	RB
cord-018572-e2qq4ngq	285	19	uncovering	uncover	VBG
cord-018572-e2qq4ngq	285	20	the	the	DT
cord-018572-e2qq4ngq	285	21	binding	binding	NN
cord-018572-e2qq4ngq	285	22	site	site	NN
cord-018572-e2qq4ngq	285	23	for	for	IN
cord-018572-e2qq4ngq	285	24	the	the	DT
cord-018572-e2qq4ngq	285	25	substrate	substrate	JJ
cord-018572-e2qq4ngq	285	26	Arf	Arf	NNP
cord-018572-e2qq4ngq	285	27	(	(	-LRB-
cord-018572-e2qq4ngq	285	28	Malaby	Malaby	NNP
cord-018572-e2qq4ngq	285	29	et	et	NNP
cord-018572-e2qq4ngq	285	30	al	al	NNP
cord-018572-e2qq4ngq	285	31	.	.	NNP
cord-018572-e2qq4ngq	285	32	2013	2013	CD
cord-018572-e2qq4ngq	285	33	)	)	-RRB-
cord-018572-e2qq4ngq	285	34	.	.	.
cord-018572-e2qq4ngq	286	1	Together	together	RB
cord-018572-e2qq4ngq	286	2	these	these	DT
cord-018572-e2qq4ngq	286	3	studies	study	NNS
cord-018572-e2qq4ngq	286	4	demonstrate	demonstrate	VBP
cord-018572-e2qq4ngq	286	5	how	how	WRB
cord-018572-e2qq4ngq	286	6	precise	precise	JJ
cord-018572-e2qq4ngq	286	7	spatial	spatial	JJ
cord-018572-e2qq4ngq	286	8	regulation	regulation	NN
cord-018572-e2qq4ngq	286	9	of	of	IN
cord-018572-e2qq4ngq	286	10	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	286	11	/	/	SYM
cord-018572-e2qq4ngq	286	12	Arno	Arno	NNP
cord-018572-e2qq4ngq	286	13	activation	activation	NN
cord-018572-e2qq4ngq	286	14	is	be	VBZ
cord-018572-e2qq4ngq	286	15	achieved	achieve	VBN
cord-018572-e2qq4ngq	286	16	:	:	:
cord-018572-e2qq4ngq	286	17	a	a	DT
cord-018572-e2qq4ngq	286	18	specific	specific	JJ
cord-018572-e2qq4ngq	286	19	phosphoinositide	phosphoinositide	NN
cord-018572-e2qq4ngq	286	20	(	(	-LRB-
cord-018572-e2qq4ngq	286	21	PIP	PIP	NNP
cord-018572-e2qq4ngq	286	22	2	2	CD
cord-018572-e2qq4ngq	286	23	and/or	and/or	CC
cord-018572-e2qq4ngq	286	24	PIP	PIP	NNP
cord-018572-e2qq4ngq	286	25	3	3	CD
cord-018572-e2qq4ngq	286	26	)	)	-RRB-
cord-018572-e2qq4ngq	286	27	,	,	,
cord-018572-e2qq4ngq	286	28	additional	additional	JJ
cord-018572-e2qq4ngq	286	29	acidic	acidic	JJ
cord-018572-e2qq4ngq	286	30	phospholipids	phospholipid	NNS
cord-018572-e2qq4ngq	286	31	,	,	,
cord-018572-e2qq4ngq	286	32	and	and	CC
cord-018572-e2qq4ngq	286	33	an	an	DT
cord-018572-e2qq4ngq	286	34	active	active	JJ
cord-018572-e2qq4ngq	286	35	Arf	Arf	NNP
cord-018572-e2qq4ngq	286	36	localized	localized	JJ
cord-018572-e2qq4ngq	286	37	to	to	IN
cord-018572-e2qq4ngq	286	38	the	the	DT
cord-018572-e2qq4ngq	286	39	plasma	plasma	NN
cord-018572-e2qq4ngq	286	40	membrane	membrane	NN
cord-018572-e2qq4ngq	286	41	must	must	MD
cord-018572-e2qq4ngq	286	42	all	all	RB
cord-018572-e2qq4ngq	286	43	coincide	coincide	VB
cord-018572-e2qq4ngq	286	44	to	to	TO
cord-018572-e2qq4ngq	286	45	relieve	relieve	VB
cord-018572-e2qq4ngq	286	46	autoinhibition	autoinhibition	NN
cord-018572-e2qq4ngq	286	47	,	,	,
cord-018572-e2qq4ngq	286	48	thus	thus	RB
cord-018572-e2qq4ngq	286	49	restricting	restrict	VBG
cord-018572-e2qq4ngq	286	50	the	the	DT
cord-018572-e2qq4ngq	286	51	membrane	membrane	NN
cord-018572-e2qq4ngq	286	52	domain	domain	NN
cord-018572-e2qq4ngq	286	53	at	at	IN
cord-018572-e2qq4ngq	286	54	which	which	WDT
cord-018572-e2qq4ngq	286	55	these	these	DT
cord-018572-e2qq4ngq	286	56	GEFs	gef	NNS
cord-018572-e2qq4ngq	286	57	can	can	MD
cord-018572-e2qq4ngq	286	58	become	become	VB
cord-018572-e2qq4ngq	286	59	active	active	JJ
cord-018572-e2qq4ngq	286	60	.	.	.
cord-018572-e2qq4ngq	287	1	The	the	DT
cord-018572-e2qq4ngq	287	2	activation	activation	NN
cord-018572-e2qq4ngq	287	3	of	of	IN
cord-018572-e2qq4ngq	287	4	cytohesins	cytohesin	NNS
cord-018572-e2qq4ngq	287	5	by	by	IN
cord-018572-e2qq4ngq	287	6	a	a	DT
cord-018572-e2qq4ngq	287	7	GTP	GTP	NNP
cord-018572-e2qq4ngq	287	8	-	-	HYPH
cord-018572-e2qq4ngq	287	9	bound	bind	VBN
cord-018572-e2qq4ngq	287	10	Arf	Arf	NNP
cord-018572-e2qq4ngq	287	11	family	family	NN
cord-018572-e2qq4ngq	287	12	member	member	NN
cord-018572-e2qq4ngq	287	13	raises	raise	VBZ
cord-018572-e2qq4ngq	287	14	the	the	DT
cord-018572-e2qq4ngq	287	15	question	question	NN
cord-018572-e2qq4ngq	287	16	of	of	IN
cord-018572-e2qq4ngq	287	17	whether	whether	IN
cord-018572-e2qq4ngq	287	18	they	-PRON-	PRP
cord-018572-e2qq4ngq	287	19	can	can	MD
cord-018572-e2qq4ngq	287	20	engage	engage	VB
cord-018572-e2qq4ngq	287	21	in	in	IN
cord-018572-e2qq4ngq	287	22	a	a	DT
cord-018572-e2qq4ngq	287	23	positive	positive	JJ
cord-018572-e2qq4ngq	287	24	feedback	feedback	NN
cord-018572-e2qq4ngq	287	25	loop	loop	NN
cord-018572-e2qq4ngq	287	26	whereby	whereby	WRB
cord-018572-e2qq4ngq	287	27	the	the	DT
cord-018572-e2qq4ngq	287	28	product	product	NN
cord-018572-e2qq4ngq	287	29	of	of	IN
cord-018572-e2qq4ngq	287	30	the	the	DT
cord-018572-e2qq4ngq	287	31	reaction	reaction	NN
cord-018572-e2qq4ngq	287	32	can	can	MD
cord-018572-e2qq4ngq	287	33	stimulate	stimulate	VB
cord-018572-e2qq4ngq	287	34	exchange	exchange	NN
cord-018572-e2qq4ngq	287	35	.	.	.
cord-018572-e2qq4ngq	288	1	Indeed	indeed	RB
cord-018572-e2qq4ngq	288	2	,	,	,
cord-018572-e2qq4ngq	288	3	such	such	PDT
cord-018572-e2qq4ngq	288	4	a	a	DT
cord-018572-e2qq4ngq	288	5	positive	positive	JJ
cord-018572-e2qq4ngq	288	6	feedback	feedback	NN
cord-018572-e2qq4ngq	288	7	loop	loop	NN
cord-018572-e2qq4ngq	288	8	has	have	VBZ
cord-018572-e2qq4ngq	288	9	been	be	VBN
cord-018572-e2qq4ngq	288	10	demonstrated	demonstrate	VBN
cord-018572-e2qq4ngq	289	1	(	(	-LRB-
cord-018572-e2qq4ngq	289	2	Stalder	Stalder	NNP
cord-018572-e2qq4ngq	289	3	et	et	FW
cord-018572-e2qq4ngq	289	4	al	al	NNP
cord-018572-e2qq4ngq	289	5	.	.	NNP
cord-018572-e2qq4ngq	289	6	2011	2011	CD
cord-018572-e2qq4ngq	289	7	)	)	-RRB-
cord-018572-e2qq4ngq	289	8	.	.	.
cord-018572-e2qq4ngq	290	1	Cytohesin	Cytohesin	NNP
cord-018572-e2qq4ngq	290	2	/	/	SYM
cord-018572-e2qq4ngq	290	3	Arno	Arno	NNP
cord-018572-e2qq4ngq	290	4	is	be	VBZ
cord-018572-e2qq4ngq	290	5	one	one	CD
cord-018572-e2qq4ngq	290	6	of	of	IN
cord-018572-e2qq4ngq	290	7	the	the	DT
cord-018572-e2qq4ngq	290	8	most	most	RBS
cord-018572-e2qq4ngq	290	9	efficient	efficient	JJ
cord-018572-e2qq4ngq	290	10	GEFs	gef	NNS
cord-018572-e2qq4ngq	290	11	in	in	IN
cord-018572-e2qq4ngq	290	12	vitro	vitro	FW
cord-018572-e2qq4ngq	290	13	on	on	IN
cord-018572-e2qq4ngq	290	14	its	-PRON-	PRP$
cord-018572-e2qq4ngq	290	15	myristoylated	myristoylated	JJ
cord-018572-e2qq4ngq	290	16	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	290	17	substrate	substrate	NN
cord-018572-e2qq4ngq	290	18	(	(	-LRB-
cord-018572-e2qq4ngq	290	19	k	k	NNP
cord-018572-e2qq4ngq	290	20	cat	cat	NN
cord-018572-e2qq4ngq	290	21	/K	/K	.
cord-018572-e2qq4ngq	290	22	m~1	m~1	NN
cord-018572-e2qq4ngq	290	23	0	0	CD
cord-018572-e2qq4ngq	291	1	6	6	CD
cord-018572-e2qq4ngq	291	2	M	M	NNP
cord-018572-e2qq4ngq	291	3	À1	À1	NNP
cord-018572-e2qq4ngq	291	4	s	s	POS
cord-018572-e2qq4ngq	291	5	À1	À1	NNP
cord-018572-e2qq4ngq	291	6	)	)	-RRB-
cord-018572-e2qq4ngq	291	7	,	,	,
cord-018572-e2qq4ngq	291	8	and	and	CC
cord-018572-e2qq4ngq	291	9	this	this	DT
cord-018572-e2qq4ngq	291	10	is	be	VBZ
cord-018572-e2qq4ngq	291	11	due	due	JJ
cord-018572-e2qq4ngq	291	12	in	in	IN
cord-018572-e2qq4ngq	291	13	part	part	NN
cord-018572-e2qq4ngq	291	14	to	to	IN
cord-018572-e2qq4ngq	291	15	the	the	DT
cord-018572-e2qq4ngq	291	16	stimulation	stimulation	NN
cord-018572-e2qq4ngq	291	17	of	of	IN
cord-018572-e2qq4ngq	291	18	exchange	exchange	NN
cord-018572-e2qq4ngq	291	19	by	by	IN
cord-018572-e2qq4ngq	291	20	interaction	interaction	NN
cord-018572-e2qq4ngq	291	21	of	of	IN
cord-018572-e2qq4ngq	291	22	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	291	23	with	with	IN
cord-018572-e2qq4ngq	291	24	the	the	DT
cord-018572-e2qq4ngq	291	25	PH	PH	NNP
cord-018572-e2qq4ngq	291	26	domain	domain	NN
cord-018572-e2qq4ngq	291	27	(	(	-LRB-
cord-018572-e2qq4ngq	291	28	Stalder	Stalder	NNP
cord-018572-e2qq4ngq	291	29	et	et	FW
cord-018572-e2qq4ngq	291	30	al	al	NNP
cord-018572-e2qq4ngq	291	31	.	.	NNP
cord-018572-e2qq4ngq	291	32	2011	2011	CD
cord-018572-e2qq4ngq	291	33	)	)	-RRB-
cord-018572-e2qq4ngq	291	34	.	.	.
cord-018572-e2qq4ngq	292	1	Given	give	VBN
cord-018572-e2qq4ngq	292	2	the	the	DT
cord-018572-e2qq4ngq	292	3	high	high	JJ
cord-018572-e2qq4ngq	292	4	level	level	NN
cord-018572-e2qq4ngq	292	5	of	of	IN
cord-018572-e2qq4ngq	292	6	efficiency	efficiency	NN
cord-018572-e2qq4ngq	292	7	of	of	IN
cord-018572-e2qq4ngq	292	8	this	this	DT
cord-018572-e2qq4ngq	292	9	GEF	GEF	NNP
cord-018572-e2qq4ngq	292	10	,	,	,
cord-018572-e2qq4ngq	292	11	it	-PRON-	PRP
cord-018572-e2qq4ngq	292	12	would	would	MD
cord-018572-e2qq4ngq	292	13	be	be	VB
cord-018572-e2qq4ngq	292	14	reasonable	reasonable	JJ
cord-018572-e2qq4ngq	292	15	to	to	TO
cord-018572-e2qq4ngq	292	16	expect	expect	VB
cord-018572-e2qq4ngq	292	17	a	a	DT
cord-018572-e2qq4ngq	292	18	tight	tight	JJ
cord-018572-e2qq4ngq	292	19	regulation	regulation	NN
cord-018572-e2qq4ngq	292	20	of	of	IN
cord-018572-e2qq4ngq	292	21	its	-PRON-	PRP$
cord-018572-e2qq4ngq	292	22	activity	activity	NN
cord-018572-e2qq4ngq	292	23	.	.	.
cord-018572-e2qq4ngq	293	1	As	as	IN
cord-018572-e2qq4ngq	293	2	described	describe	VBN
cord-018572-e2qq4ngq	293	3	above	above	RB
cord-018572-e2qq4ngq	293	4	,	,	,
cord-018572-e2qq4ngq	293	5	one	one	CD
cord-018572-e2qq4ngq	293	6	such	such	JJ
cord-018572-e2qq4ngq	293	7	mechanism	mechanism	NN
cord-018572-e2qq4ngq	293	8	is	be	VBZ
cord-018572-e2qq4ngq	293	9	found	find	VBN
cord-018572-e2qq4ngq	293	10	in	in	IN
cord-018572-e2qq4ngq	293	11	the	the	DT
cord-018572-e2qq4ngq	293	12	absolute	absolute	JJ
cord-018572-e2qq4ngq	293	13	requirement	requirement	NN
cord-018572-e2qq4ngq	293	14	for	for	IN
cord-018572-e2qq4ngq	293	15	an	an	DT
cord-018572-e2qq4ngq	293	16	activating	activate	VBG
cord-018572-e2qq4ngq	293	17	Arf	Arf	NNP
cord-018572-e2qq4ngq	293	18	protein	protein	NN
cord-018572-e2qq4ngq	293	19	to	to	TO
cord-018572-e2qq4ngq	293	20	relieve	relieve	VB
cord-018572-e2qq4ngq	293	21	autoinhibition	autoinhibition	NN
cord-018572-e2qq4ngq	293	22	(	(	-LRB-
cord-018572-e2qq4ngq	293	23	Stalder	Stalder	NNP
cord-018572-e2qq4ngq	293	24	et	et	FW
cord-018572-e2qq4ngq	293	25	al	al	NNP
cord-018572-e2qq4ngq	293	26	.	.	NNP
cord-018572-e2qq4ngq	293	27	2011	2011	CD
cord-018572-e2qq4ngq	293	28	)	)	-RRB-
cord-018572-e2qq4ngq	293	29	.	.	.
cord-018572-e2qq4ngq	294	1	This	this	DT
cord-018572-e2qq4ngq	294	2	study	study	NN
cord-018572-e2qq4ngq	294	3	also	also	RB
cord-018572-e2qq4ngq	294	4	showed	show	VBD
cord-018572-e2qq4ngq	294	5	that	that	IN
cord-018572-e2qq4ngq	294	6	other	other	JJ
cord-018572-e2qq4ngq	294	7	Arf	Arf	NNP
cord-018572-e2qq4ngq	294	8	effectors	effector	NNS
cord-018572-e2qq4ngq	294	9	are	be	VBP
cord-018572-e2qq4ngq	294	10	able	able	JJ
cord-018572-e2qq4ngq	294	11	to	to	TO
cord-018572-e2qq4ngq	294	12	compete	compete	VB
cord-018572-e2qq4ngq	294	13	with	with	IN
cord-018572-e2qq4ngq	294	14	the	the	DT
cord-018572-e2qq4ngq	294	15	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	294	16	/	/	SYM
cord-018572-e2qq4ngq	294	17	Arno	Arno	NNP
cord-018572-e2qq4ngq	294	18	PH	PH	NNP
cord-018572-e2qq4ngq	294	19	domain	domain	NN
cord-018572-e2qq4ngq	294	20	for	for	IN
cord-018572-e2qq4ngq	294	21	available	available	JJ
cord-018572-e2qq4ngq	294	22	Arf	Arf	NNP
cord-018572-e2qq4ngq	294	23	-	-	HYPH
cord-018572-e2qq4ngq	294	24	GTP	GTP	NNP
cord-018572-e2qq4ngq	294	25	,	,	,
cord-018572-e2qq4ngq	294	26	suggesting	suggest	VBG
cord-018572-e2qq4ngq	294	27	that	that	IN
cord-018572-e2qq4ngq	294	28	the	the	DT
cord-018572-e2qq4ngq	294	29	activating	activate	VBG
cord-018572-e2qq4ngq	294	30	Arf	Arf	NNP
cord-018572-e2qq4ngq	294	31	protein	protein	NN
cord-018572-e2qq4ngq	294	32	(	(	-LRB-
cord-018572-e2qq4ngq	294	33	Arl4-GTP	arl4-gtp	NN
cord-018572-e2qq4ngq	294	34	or	or	CC
cord-018572-e2qq4ngq	294	35	Arf6-GTP	arf6-gtp	NN
cord-018572-e2qq4ngq	294	36	)	)	-RRB-
cord-018572-e2qq4ngq	294	37	must	must	MD
cord-018572-e2qq4ngq	294	38	be	be	VB
cord-018572-e2qq4ngq	294	39	present	present	JJ
cord-018572-e2qq4ngq	294	40	in	in	IN
cord-018572-e2qq4ngq	294	41	excess	excess	NN
cord-018572-e2qq4ngq	294	42	of	of	IN
cord-018572-e2qq4ngq	294	43	other	other	JJ
cord-018572-e2qq4ngq	294	44	effectors	effector	NNS
cord-018572-e2qq4ngq	294	45	to	to	TO
cord-018572-e2qq4ngq	294	46	reach	reach	VB
cord-018572-e2qq4ngq	294	47	a	a	DT
cord-018572-e2qq4ngq	294	48	level	level	NN
cord-018572-e2qq4ngq	294	49	sufficient	sufficient	JJ
cord-018572-e2qq4ngq	294	50	to	to	TO
cord-018572-e2qq4ngq	294	51	stimulate	stimulate	VB
cord-018572-e2qq4ngq	294	52	this	this	DT
cord-018572-e2qq4ngq	294	53	GEF	gef	NN
cord-018572-e2qq4ngq	294	54	(	(	-LRB-
cord-018572-e2qq4ngq	294	55	Stalder	Stalder	NNP
cord-018572-e2qq4ngq	294	56	et	et	FW
cord-018572-e2qq4ngq	294	57	al	al	NNP
cord-018572-e2qq4ngq	294	58	.	.	NNP
cord-018572-e2qq4ngq	294	59	2011	2011	CD
cord-018572-e2qq4ngq	294	60	)	)	-RRB-
cord-018572-e2qq4ngq	294	61	.	.	.
cord-018572-e2qq4ngq	295	1	Hence	hence	RB
cord-018572-e2qq4ngq	295	2	,	,	,
cord-018572-e2qq4ngq	295	3	in	in	IN
cord-018572-e2qq4ngq	295	4	order	order	NN
cord-018572-e2qq4ngq	295	5	to	to	TO
cord-018572-e2qq4ngq	295	6	activate	activate	VB
cord-018572-e2qq4ngq	295	7	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	295	8	/	/	SYM
cord-018572-e2qq4ngq	295	9	Arno	Arno	NNP
cord-018572-e2qq4ngq	295	10	,	,	,
cord-018572-e2qq4ngq	295	11	a	a	DT
cord-018572-e2qq4ngq	295	12	burst	burst	NN
cord-018572-e2qq4ngq	295	13	of	of	IN
cord-018572-e2qq4ngq	296	1	Arl4-or	Arl4-or	NNP
cord-018572-e2qq4ngq	296	2	Arf6-GTP	Arf6-GTP	NNP
cord-018572-e2qq4ngq	296	3	must	must	MD
cord-018572-e2qq4ngq	296	4	be	be	VB
cord-018572-e2qq4ngq	296	5	produced	produce	VBN
cord-018572-e2qq4ngq	296	6	to	to	TO
cord-018572-e2qq4ngq	296	7	overcome	overcome	VB
cord-018572-e2qq4ngq	296	8	autoinhibition	autoinhibition	NN
cord-018572-e2qq4ngq	296	9	,	,	,
cord-018572-e2qq4ngq	296	10	but	but	CC
cord-018572-e2qq4ngq	296	11	once	once	RB
cord-018572-e2qq4ngq	296	12	in	in	IN
cord-018572-e2qq4ngq	296	13	its	-PRON-	PRP$
cord-018572-e2qq4ngq	296	14	active	active	JJ
cord-018572-e2qq4ngq	296	15	conformation	conformation	NN
cord-018572-e2qq4ngq	296	16	,	,	,
cord-018572-e2qq4ngq	296	17	this	this	DT
cord-018572-e2qq4ngq	296	18	GEF	GEF	NNP
cord-018572-e2qq4ngq	296	19	has	have	VBZ
cord-018572-e2qq4ngq	296	20	a	a	DT
cord-018572-e2qq4ngq	296	21	high	high	JJ
cord-018572-e2qq4ngq	296	22	capacity	capacity	NN
cord-018572-e2qq4ngq	296	23	to	to	TO
cord-018572-e2qq4ngq	296	24	stimulate	stimulate	VB
cord-018572-e2qq4ngq	296	25	exchange	exchange	NN
cord-018572-e2qq4ngq	296	26	on	on	IN
cord-018572-e2qq4ngq	296	27	its	-PRON-	PRP$
cord-018572-e2qq4ngq	296	28	Arf	Arf	NNP
cord-018572-e2qq4ngq	296	29	substrates	substrate	NNS
cord-018572-e2qq4ngq	296	30	due	due	JJ
cord-018572-e2qq4ngq	296	31	to	to	IN
cord-018572-e2qq4ngq	296	32	the	the	DT
cord-018572-e2qq4ngq	296	33	effect	effect	NN
cord-018572-e2qq4ngq	296	34	of	of	IN
cord-018572-e2qq4ngq	296	35	positive	positive	JJ
cord-018572-e2qq4ngq	296	36	feedback	feedback	NN
cord-018572-e2qq4ngq	296	37	.	.	.
cord-018572-e2qq4ngq	297	1	Interestingly	interestingly	RB
cord-018572-e2qq4ngq	297	2	,	,	,
cord-018572-e2qq4ngq	297	3	stimulation	stimulation	NN
cord-018572-e2qq4ngq	297	4	of	of	IN
cord-018572-e2qq4ngq	297	5	exchange	exchange	NN
cord-018572-e2qq4ngq	297	6	activity	activity	NN
cord-018572-e2qq4ngq	297	7	by	by	IN
cord-018572-e2qq4ngq	297	8	the	the	DT
cord-018572-e2qq4ngq	297	9	product	product	NN
cord-018572-e2qq4ngq	297	10	of	of	IN
cord-018572-e2qq4ngq	297	11	the	the	DT
cord-018572-e2qq4ngq	297	12	reaction	reaction	NN
cord-018572-e2qq4ngq	297	13	has	have	VBZ
cord-018572-e2qq4ngq	297	14	been	be	VBN
cord-018572-e2qq4ngq	297	15	demonstrated	demonstrate	VBN
cord-018572-e2qq4ngq	297	16	for	for	IN
cord-018572-e2qq4ngq	297	17	the	the	DT
cord-018572-e2qq4ngq	297	18	trans	trans	NNP
cord-018572-e2qq4ngq	297	19	-	-	NNP
cord-018572-e2qq4ngq	297	20	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	297	21	localized	localize	VBN
cord-018572-e2qq4ngq	297	22	Sec7p	sec7p	NN
cord-018572-e2qq4ngq	297	23	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	297	24	GEF	GEF	NNP
cord-018572-e2qq4ngq	297	25	(	(	-LRB-
cord-018572-e2qq4ngq	297	26	Richardson	Richardson	NNP
cord-018572-e2qq4ngq	297	27	et	et	NNP
cord-018572-e2qq4ngq	297	28	al	al	NNP
cord-018572-e2qq4ngq	297	29	.	.	.
cord-018572-e2qq4ngq	297	30	2012	2012	CD
cord-018572-e2qq4ngq	297	31	)	)	-RRB-
cord-018572-e2qq4ngq	297	32	,	,	,
cord-018572-e2qq4ngq	297	33	as	as	RB
cord-018572-e2qq4ngq	297	34	well	well	RB
cord-018572-e2qq4ngq	297	35	as	as	IN
cord-018572-e2qq4ngq	297	36	for	for	IN
cord-018572-e2qq4ngq	297	37	the	the	DT
cord-018572-e2qq4ngq	297	38	Ras	Ras	NNP
cord-018572-e2qq4ngq	297	39	GEF	GEF	NNP
cord-018572-e2qq4ngq	297	40	Sos	Sos	NNP
cord-018572-e2qq4ngq	297	41	(	(	-LRB-
cord-018572-e2qq4ngq	297	42	Boykevisch	Boykevisch	NNP
cord-018572-e2qq4ngq	297	43	et	et	NNP
cord-018572-e2qq4ngq	297	44	al	al	NNP
cord-018572-e2qq4ngq	297	45	.	.	.
cord-018572-e2qq4ngq	297	46	2006	2006	CD
cord-018572-e2qq4ngq	297	47	)	)	-RRB-
cord-018572-e2qq4ngq	297	48	.	.	.
cord-018572-e2qq4ngq	298	1	Hence	hence	RB
cord-018572-e2qq4ngq	298	2	,	,	,
cord-018572-e2qq4ngq	298	3	this	this	DT
cord-018572-e2qq4ngq	298	4	type	type	NN
cord-018572-e2qq4ngq	298	5	of	of	IN
cord-018572-e2qq4ngq	298	6	positive	positive	JJ
cord-018572-e2qq4ngq	298	7	feedback	feedback	NN
cord-018572-e2qq4ngq	298	8	regulation	regulation	NN
cord-018572-e2qq4ngq	298	9	may	may	MD
cord-018572-e2qq4ngq	298	10	be	be	VB
cord-018572-e2qq4ngq	298	11	a	a	DT
cord-018572-e2qq4ngq	298	12	general	general	JJ
cord-018572-e2qq4ngq	298	13	property	property	NN
cord-018572-e2qq4ngq	298	14	of	of	IN
cord-018572-e2qq4ngq	298	15	small	small	JJ
cord-018572-e2qq4ngq	298	16	G	g	NN
cord-018572-e2qq4ngq	298	17	proteins	protein	NNS
cord-018572-e2qq4ngq	298	18	.	.	.
cord-018572-e2qq4ngq	299	1	In	in	IN
cord-018572-e2qq4ngq	299	2	the	the	DT
cord-018572-e2qq4ngq	299	3	case	case	NN
cord-018572-e2qq4ngq	299	4	of	of	IN
cord-018572-e2qq4ngq	299	5	Sec7p	Sec7p	NNP
cord-018572-e2qq4ngq	299	6	,	,	,
cord-018572-e2qq4ngq	299	7	the	the	DT
cord-018572-e2qq4ngq	299	8	HDS1	HDS1	NNP
cord-018572-e2qq4ngq	299	9	domain	domain	NN
cord-018572-e2qq4ngq	299	10	downstream	downstream	NN
cord-018572-e2qq4ngq	299	11	of	of	IN
cord-018572-e2qq4ngq	299	12	the	the	DT
cord-018572-e2qq4ngq	299	13	catalytic	catalytic	JJ
cord-018572-e2qq4ngq	299	14	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	299	15	domain	domain	NN
cord-018572-e2qq4ngq	299	16	binds	bind	VBZ
cord-018572-e2qq4ngq	299	17	to	to	IN
cord-018572-e2qq4ngq	299	18	membranes	membrane	NNS
cord-018572-e2qq4ngq	299	19	and	and	CC
cord-018572-e2qq4ngq	299	20	to	to	IN
cord-018572-e2qq4ngq	299	21	Arf1-GTP	arf1-gtp	VB
cord-018572-e2qq4ngq	300	1	both	both	DT
cord-018572-e2qq4ngq	300	2	in	in	IN
cord-018572-e2qq4ngq	300	3	vitro	vitro	FW
cord-018572-e2qq4ngq	300	4	and	and	CC
cord-018572-e2qq4ngq	300	5	in	in	IN
cord-018572-e2qq4ngq	300	6	cells	cell	NNS
cord-018572-e2qq4ngq	300	7	,	,	,
cord-018572-e2qq4ngq	300	8	and	and	CC
cord-018572-e2qq4ngq	300	9	like	like	IN
cord-018572-e2qq4ngq	300	10	the	the	DT
cord-018572-e2qq4ngq	300	11	PH	PH	NNP
cord-018572-e2qq4ngq	300	12	domain	domain	NN
cord-018572-e2qq4ngq	300	13	in	in	IN
cord-018572-e2qq4ngq	300	14	the	the	DT
cord-018572-e2qq4ngq	300	15	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	300	16	proteins	protein	NNS
cord-018572-e2qq4ngq	300	17	,	,	,
cord-018572-e2qq4ngq	300	18	is	be	VBZ
cord-018572-e2qq4ngq	300	19	responsible	responsible	JJ
cord-018572-e2qq4ngq	300	20	for	for	IN
cord-018572-e2qq4ngq	300	21	mediating	mediate	VBG
cord-018572-e2qq4ngq	300	22	relief	relief	NN
cord-018572-e2qq4ngq	300	23	of	of	IN
cord-018572-e2qq4ngq	300	24	autoinhibition	autoinhibition	NN
cord-018572-e2qq4ngq	300	25	and	and	CC
cord-018572-e2qq4ngq	300	26	the	the	DT
cord-018572-e2qq4ngq	300	27	positive	positive	JJ
cord-018572-e2qq4ngq	300	28	feedback	feedback	NN
cord-018572-e2qq4ngq	300	29	effect	effect	NN
cord-018572-e2qq4ngq	300	30	(	(	-LRB-
cord-018572-e2qq4ngq	300	31	Richardson	Richardson	NNP
cord-018572-e2qq4ngq	300	32	et	et	NNP
cord-018572-e2qq4ngq	300	33	al	al	NNP
cord-018572-e2qq4ngq	300	34	.	.	NNP
cord-018572-e2qq4ngq	300	35	2012	2012	CD
cord-018572-e2qq4ngq	300	36	)	)	-RRB-
cord-018572-e2qq4ngq	300	37	.	.	.
cord-018572-e2qq4ngq	301	1	For	for	IN
cord-018572-e2qq4ngq	301	2	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	301	3	,	,	,
cord-018572-e2qq4ngq	301	4	the	the	DT
cord-018572-e2qq4ngq	301	5	HDS1-Arf1-GTP	hds1-arf1-gtp	NN
cord-018572-e2qq4ngq	301	6	interaction	interaction	NN
cord-018572-e2qq4ngq	301	7	is	be	VBZ
cord-018572-e2qq4ngq	301	8	required	require	VBN
cord-018572-e2qq4ngq	301	9	to	to	TO
cord-018572-e2qq4ngq	301	10	maintain	maintain	VB
cord-018572-e2qq4ngq	301	11	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	301	12	localization	localization	NN
cord-018572-e2qq4ngq	301	13	of	of	IN
cord-018572-e2qq4ngq	301	14	Sec7p	sec7p	NN
cord-018572-e2qq4ngq	302	1	(	(	-LRB-
cord-018572-e2qq4ngq	302	2	Richardson	Richardson	NNP
cord-018572-e2qq4ngq	302	3	et	et	NNP
cord-018572-e2qq4ngq	302	4	al	al	NNP
cord-018572-e2qq4ngq	302	5	.	.	NNP
cord-018572-e2qq4ngq	302	6	2012	2012	CD
cord-018572-e2qq4ngq	302	7	)	)	-RRB-
cord-018572-e2qq4ngq	302	8	.	.	.
cord-018572-e2qq4ngq	303	1	Interestingly	interestingly	RB
cord-018572-e2qq4ngq	303	2	,	,	,
cord-018572-e2qq4ngq	303	3	reduction	reduction	NN
cord-018572-e2qq4ngq	303	4	of	of	IN
cord-018572-e2qq4ngq	303	5	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	303	6	levels	level	NNS
cord-018572-e2qq4ngq	303	7	in	in	IN
cord-018572-e2qq4ngq	303	8	yeast	yeast	NN
cord-018572-e2qq4ngq	303	9	cells	cell	NNS
cord-018572-e2qq4ngq	303	10	is	be	VBZ
cord-018572-e2qq4ngq	303	11	particularly	particularly	RB
cord-018572-e2qq4ngq	303	12	detrimental	detrimental	JJ
cord-018572-e2qq4ngq	303	13	to	to	IN
cord-018572-e2qq4ngq	303	14	trans	trans	NNP
cord-018572-e2qq4ngq	303	15	-	-	JJ
cord-018572-e2qq4ngq	303	16	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	303	17	function	function	NN
cord-018572-e2qq4ngq	304	1	(	(	-LRB-
cord-018572-e2qq4ngq	304	2	Gall	Gall	NNP
cord-018572-e2qq4ngq	304	3	et	et	FW
cord-018572-e2qq4ngq	304	4	al	al	NNP
cord-018572-e2qq4ngq	304	5	.	.	.
cord-018572-e2qq4ngq	304	6	2000	2000	CD
cord-018572-e2qq4ngq	304	7	)	)	-RRB-
cord-018572-e2qq4ngq	304	8	,	,	,
cord-018572-e2qq4ngq	304	9	a	a	DT
cord-018572-e2qq4ngq	304	10	result	result	NN
cord-018572-e2qq4ngq	304	11	that	that	WDT
cord-018572-e2qq4ngq	304	12	could	could	MD
cord-018572-e2qq4ngq	304	13	potentially	potentially	RB
cord-018572-e2qq4ngq	304	14	be	be	VB
cord-018572-e2qq4ngq	304	15	explained	explain	VBN
cord-018572-e2qq4ngq	304	16	by	by	IN
cord-018572-e2qq4ngq	304	17	the	the	DT
cord-018572-e2qq4ngq	304	18	need	need	NN
cord-018572-e2qq4ngq	304	19	for	for	IN
cord-018572-e2qq4ngq	304	20	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	304	21	to	to	TO
cord-018572-e2qq4ngq	304	22	have	have	VB
cord-018572-e2qq4ngq	304	23	a	a	DT
cord-018572-e2qq4ngq	304	24	high	high	JJ
cord-018572-e2qq4ngq	304	25	level	level	NN
cord-018572-e2qq4ngq	304	26	of	of	IN
cord-018572-e2qq4ngq	304	27	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	304	28	for	for	IN
cord-018572-e2qq4ngq	304	29	its	-PRON-	PRP$
cord-018572-e2qq4ngq	304	30	autocatalytic	autocatalytic	JJ
cord-018572-e2qq4ngq	304	31	activity	activity	NN
cord-018572-e2qq4ngq	304	32	.	.	.
cord-018572-e2qq4ngq	305	1	One	one	CD
cord-018572-e2qq4ngq	305	2	consequence	consequence	NN
cord-018572-e2qq4ngq	305	3	of	of	IN
cord-018572-e2qq4ngq	305	4	this	this	DT
cord-018572-e2qq4ngq	305	5	mechanism	mechanism	NN
cord-018572-e2qq4ngq	305	6	could	could	MD
cord-018572-e2qq4ngq	305	7	be	be	VB
cord-018572-e2qq4ngq	305	8	to	to	TO
cord-018572-e2qq4ngq	305	9	maintain	maintain	VB
cord-018572-e2qq4ngq	305	10	directionality	directionality	NN
cord-018572-e2qq4ngq	305	11	in	in	IN
cord-018572-e2qq4ngq	305	12	trafficking	trafficking	NN
cord-018572-e2qq4ngq	305	13	through	through	IN
cord-018572-e2qq4ngq	305	14	the	the	DT
cord-018572-e2qq4ngq	305	15	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	305	16	.	.	.
cord-018572-e2qq4ngq	306	1	As	as	IN
cord-018572-e2qq4ngq	306	2	described	describe	VBN
cord-018572-e2qq4ngq	306	3	above	above	RB
cord-018572-e2qq4ngq	306	4	,	,	,
cord-018572-e2qq4ngq	306	5	the	the	DT
cord-018572-e2qq4ngq	306	6	GBF	GBF	NNP
cord-018572-e2qq4ngq	306	7	/	/	SYM
cord-018572-e2qq4ngq	306	8	Gea	Gea	NNP
cord-018572-e2qq4ngq	306	9	family	family	NN
cord-018572-e2qq4ngq	306	10	of	of	IN
cord-018572-e2qq4ngq	306	11	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	306	12	act	act	VBP
cord-018572-e2qq4ngq	306	13	early	early	RB
cord-018572-e2qq4ngq	306	14	in	in	IN
cord-018572-e2qq4ngq	306	15	the	the	DT
cord-018572-e2qq4ngq	306	16	secretory	secretory	JJ
cord-018572-e2qq4ngq	306	17	pathway	pathway	NN
cord-018572-e2qq4ngq	306	18	,	,	,
cord-018572-e2qq4ngq	306	19	at	at	IN
cord-018572-e2qq4ngq	306	20	the	the	DT
cord-018572-e2qq4ngq	306	21	cis	cis	NNP
cord-018572-e2qq4ngq	306	22	-	-	HYPH
cord-018572-e2qq4ngq	306	23	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	306	24	,	,	,
cord-018572-e2qq4ngq	306	25	and	and	CC
cord-018572-e2qq4ngq	306	26	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	306	27	/	/	SYM
cord-018572-e2qq4ngq	306	28	BIG	BIG	NNP
cord-018572-e2qq4ngq	306	29	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	306	30	act	act	NN
cord-018572-e2qq4ngq	306	31	later	later	RB
cord-018572-e2qq4ngq	306	32	at	at	IN
cord-018572-e2qq4ngq	306	33	the	the	DT
cord-018572-e2qq4ngq	306	34	trans	trans	NNP
cord-018572-e2qq4ngq	306	35	-	-	NNP
cord-018572-e2qq4ngq	306	36	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	306	37	.	.	.
cord-018572-e2qq4ngq	307	1	Interestingly	interestingly	RB
cord-018572-e2qq4ngq	307	2	,	,	,
cord-018572-e2qq4ngq	307	3	the	the	DT
cord-018572-e2qq4ngq	307	4	HDS1	HDS1	NNP
cord-018572-e2qq4ngq	307	5	domain	domain	NN
cord-018572-e2qq4ngq	307	6	of	of	IN
cord-018572-e2qq4ngq	307	7	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	307	8	,	,	,
cord-018572-e2qq4ngq	307	9	also	also	RB
cord-018572-e2qq4ngq	307	10	immediately	immediately	RB
cord-018572-e2qq4ngq	307	11	downstream	downstream	RB
cord-018572-e2qq4ngq	307	12	of	of	IN
cord-018572-e2qq4ngq	307	13	the	the	DT
cord-018572-e2qq4ngq	307	14	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	307	15	domain	domain	NN
cord-018572-e2qq4ngq	307	16	,	,	,
cord-018572-e2qq4ngq	307	17	is	be	VBZ
cord-018572-e2qq4ngq	307	18	a	a	DT
cord-018572-e2qq4ngq	307	19	direct	direct	JJ
cord-018572-e2qq4ngq	307	20	lipid	lipid	NN
cord-018572-e2qq4ngq	307	21	binding	bind	VBG
cord-018572-e2qq4ngq	307	22	domain	domain	NN
cord-018572-e2qq4ngq	307	23	that	that	WDT
cord-018572-e2qq4ngq	307	24	does	do	VBZ
cord-018572-e2qq4ngq	307	25	not	not	RB
cord-018572-e2qq4ngq	307	26	require	require	VB
cord-018572-e2qq4ngq	307	27	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	307	28	for	for	IN
cord-018572-e2qq4ngq	307	29	membrane	membrane	NN
cord-018572-e2qq4ngq	307	30	binding	bind	VBG
cord-018572-e2qq4ngq	307	31	like	like	IN
cord-018572-e2qq4ngq	307	32	Sec7p	Sec7p	NNP
cord-018572-e2qq4ngq	307	33	does	do	VBZ
cord-018572-e2qq4ngq	307	34	(	(	-LRB-
cord-018572-e2qq4ngq	307	35	Bouvet	Bouvet	NNP
cord-018572-e2qq4ngq	307	36	et	et	NNP
cord-018572-e2qq4ngq	307	37	al	al	NNP
cord-018572-e2qq4ngq	307	38	.	.	NNP
cord-018572-e2qq4ngq	307	39	2013	2013	CD
cord-018572-e2qq4ngq	307	40	)	)	-RRB-
cord-018572-e2qq4ngq	307	41	.	.	.
cord-018572-e2qq4ngq	308	1	These	these	DT
cord-018572-e2qq4ngq	308	2	results	result	NNS
cord-018572-e2qq4ngq	308	3	taken	take	VBN
cord-018572-e2qq4ngq	308	4	together	together	RB
cord-018572-e2qq4ngq	308	5	suggest	suggest	VBP
cord-018572-e2qq4ngq	308	6	that	that	IN
cord-018572-e2qq4ngq	308	7	one	one	CD
cord-018572-e2qq4ngq	308	8	mechanism	mechanism	NN
cord-018572-e2qq4ngq	308	9	to	to	TO
cord-018572-e2qq4ngq	308	10	drive	drive	VB
cord-018572-e2qq4ngq	308	11	trafficking	traffic	VBG
cord-018572-e2qq4ngq	308	12	forward	forward	RB
cord-018572-e2qq4ngq	308	13	through	through	IN
cord-018572-e2qq4ngq	308	14	the	the	DT
cord-018572-e2qq4ngq	308	15	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	308	16	is	be	VBZ
cord-018572-e2qq4ngq	308	17	initial	initial	JJ
cord-018572-e2qq4ngq	308	18	recruitment	recruitment	NN
cord-018572-e2qq4ngq	308	19	of	of	IN
cord-018572-e2qq4ngq	308	20	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	308	21	/	/	SYM
cord-018572-e2qq4ngq	308	22	Gea	Gea	NNP
cord-018572-e2qq4ngq	308	23	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	308	24	to	to	TO
cord-018572-e2qq4ngq	308	25	produce	produce	VB
cord-018572-e2qq4ngq	308	26	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	308	27	,	,	,
cord-018572-e2qq4ngq	308	28	which	which	WDT
cord-018572-e2qq4ngq	308	29	then	then	RB
cord-018572-e2qq4ngq	308	30	can	can	MD
cord-018572-e2qq4ngq	308	31	recruit	recruit	VB
cord-018572-e2qq4ngq	308	32	the	the	DT
cord-018572-e2qq4ngq	308	33	later	later	RB
cord-018572-e2qq4ngq	308	34	-	-	HYPH
cord-018572-e2qq4ngq	308	35	acting	act	VBG
cord-018572-e2qq4ngq	308	36	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	308	37	/	/	SYM
cord-018572-e2qq4ngq	308	38	BIG	big	JJ
cord-018572-e2qq4ngq	308	39	GEFs	gef	NNS
cord-018572-e2qq4ngq	308	40	to	to	IN
cord-018572-e2qq4ngq	308	41	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	308	42	membranes	membrane	NNS
cord-018572-e2qq4ngq	308	43	.	.	.
cord-018572-e2qq4ngq	309	1	Whether	whether	IN
cord-018572-e2qq4ngq	309	2	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	309	3	,	,	,
cord-018572-e2qq4ngq	309	4	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	309	5	,	,	,
cord-018572-e2qq4ngq	309	6	or	or	CC
cord-018572-e2qq4ngq	309	7	both	both	DT
cord-018572-e2qq4ngq	309	8	are	be	VBP
cord-018572-e2qq4ngq	309	9	the	the	DT
cord-018572-e2qq4ngq	309	10	primary	primary	JJ
cord-018572-e2qq4ngq	309	11	substrates	substrate	NNS
cord-018572-e2qq4ngq	309	12	for	for	IN
cord-018572-e2qq4ngq	309	13	the	the	DT
cord-018572-e2qq4ngq	309	14	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	309	15	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	309	16	has	have	VBZ
cord-018572-e2qq4ngq	309	17	been	be	VBN
cord-018572-e2qq4ngq	309	18	a	a	DT
cord-018572-e2qq4ngq	309	19	long	long	RB
cord-018572-e2qq4ngq	309	20	-	-	HYPH
cord-018572-e2qq4ngq	309	21	standing	stand	VBG
cord-018572-e2qq4ngq	309	22	controversy	controversy	NN
cord-018572-e2qq4ngq	309	23	and	and	CC
cord-018572-e2qq4ngq	309	24	is	be	VBZ
cord-018572-e2qq4ngq	309	25	still	still	RB
cord-018572-e2qq4ngq	309	26	an	an	DT
cord-018572-e2qq4ngq	309	27	open	open	JJ
cord-018572-e2qq4ngq	309	28	question	question	NN
cord-018572-e2qq4ngq	309	29	.	.	.
cord-018572-e2qq4ngq	310	1	However	however	RB
cord-018572-e2qq4ngq	310	2	,	,	,
cord-018572-e2qq4ngq	310	3	Arf6-GTP	Arf6-GTP	NNP
cord-018572-e2qq4ngq	310	4	is	be	VBZ
cord-018572-e2qq4ngq	310	5	more	more	RBR
cord-018572-e2qq4ngq	310	6	efficient	efficient	JJ
cord-018572-e2qq4ngq	310	7	at	at	IN
cord-018572-e2qq4ngq	310	8	relieving	relieve	VBG
cord-018572-e2qq4ngq	310	9	autoinhibition	autoinhibition	NN
cord-018572-e2qq4ngq	310	10	of	of	IN
cord-018572-e2qq4ngq	310	11	cytohesins	cytohesin	NNS
cord-018572-e2qq4ngq	310	12	than	than	IN
cord-018572-e2qq4ngq	310	13	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	310	14	,	,	,
cord-018572-e2qq4ngq	310	15	both	both	DT
cord-018572-e2qq4ngq	310	16	in	in	IN
cord-018572-e2qq4ngq	310	17	vitro	vitro	FW
cord-018572-e2qq4ngq	310	18	and	and	CC
cord-018572-e2qq4ngq	310	19	in	in	IN
cord-018572-e2qq4ngq	310	20	cells	cell	NNS
cord-018572-e2qq4ngq	311	1	(	(	-LRB-
cord-018572-e2qq4ngq	311	2	Cohen	Cohen	NNP
cord-018572-e2qq4ngq	311	3	et	et	NNP
cord-018572-e2qq4ngq	311	4	al	al	NNP
cord-018572-e2qq4ngq	311	5	.	.	.
cord-018572-e2qq4ngq	312	1	2007	2007	CD
cord-018572-e2qq4ngq	312	2	;	;	:
cord-018572-e2qq4ngq	312	3	DiNitto	DiNitto	NNP
cord-018572-e2qq4ngq	312	4	et	et	NNP
cord-018572-e2qq4ngq	312	5	al	al	NNP
cord-018572-e2qq4ngq	312	6	.	.	NNP
cord-018572-e2qq4ngq	312	7	2007	2007	CD
cord-018572-e2qq4ngq	312	8	)	)	-RRB-
cord-018572-e2qq4ngq	312	9	.	.	.
cord-018572-e2qq4ngq	313	1	This	this	DT
cord-018572-e2qq4ngq	313	2	fact	fact	NN
cord-018572-e2qq4ngq	313	3	,	,	,
cord-018572-e2qq4ngq	313	4	combined	combine	VBN
cord-018572-e2qq4ngq	313	5	with	with	IN
cord-018572-e2qq4ngq	313	6	the	the	DT
cord-018572-e2qq4ngq	313	7	requirement	requirement	NN
cord-018572-e2qq4ngq	313	8	for	for	IN
cord-018572-e2qq4ngq	313	9	acidic	acidic	JJ
cord-018572-e2qq4ngq	313	10	phospholipids	phospholipid	NNS
cord-018572-e2qq4ngq	313	11	in	in	IN
cord-018572-e2qq4ngq	313	12	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	313	13	membrane	membrane	NN
cord-018572-e2qq4ngq	313	14	binding	binding	NN
cord-018572-e2qq4ngq	313	15	,	,	,
cord-018572-e2qq4ngq	313	16	would	would	MD
cord-018572-e2qq4ngq	313	17	restrict	restrict	VB
cord-018572-e2qq4ngq	313	18	activation	activation	NN
cord-018572-e2qq4ngq	313	19	of	of	IN
cord-018572-e2qq4ngq	313	20	cytohesins	cytohesin	NNS
cord-018572-e2qq4ngq	313	21	to	to	IN
cord-018572-e2qq4ngq	313	22	PM	PM	NNP
cord-018572-e2qq4ngq	313	23	or	or	CC
cord-018572-e2qq4ngq	313	24	endosomal	endosomal	NNP
cord-018572-e2qq4ngq	313	25	membranes	membrane	NNS
cord-018572-e2qq4ngq	313	26	.	.	.
cord-018572-e2qq4ngq	314	1	These	these	DT
cord-018572-e2qq4ngq	314	2	results	result	NNS
cord-018572-e2qq4ngq	314	3	illustrate	illustrate	VBP
cord-018572-e2qq4ngq	314	4	the	the	DT
cord-018572-e2qq4ngq	314	5	complexity	complexity	NN
cord-018572-e2qq4ngq	314	6	of	of	IN
cord-018572-e2qq4ngq	314	7	Arno	Arno	NNP
cord-018572-e2qq4ngq	314	8	activation	activation	NN
cord-018572-e2qq4ngq	314	9	and	and	CC
cord-018572-e2qq4ngq	314	10	shed	shed	VBD
cord-018572-e2qq4ngq	314	11	light	light	NN
cord-018572-e2qq4ngq	314	12	on	on	IN
cord-018572-e2qq4ngq	314	13	this	this	DT
cord-018572-e2qq4ngq	314	14	long	long	RB
cord-018572-e2qq4ngq	314	15	-	-	HYPH
cord-018572-e2qq4ngq	314	16	standing	stand	VBG
cord-018572-e2qq4ngq	314	17	debate	debate	NN
cord-018572-e2qq4ngq	314	18	over	over	IN
cord-018572-e2qq4ngq	314	19	the	the	DT
cord-018572-e2qq4ngq	314	20	physiological	physiological	JJ
cord-018572-e2qq4ngq	314	21	substrate	substrate	NN
cord-018572-e2qq4ngq	314	22	of	of	IN
cord-018572-e2qq4ngq	314	23	cytohesins	cytohesin	NNS
cord-018572-e2qq4ngq	314	24	in	in	IN
cord-018572-e2qq4ngq	314	25	cells	cell	NNS
cord-018572-e2qq4ngq	314	26	.	.	.
cord-018572-e2qq4ngq	315	1	The	the	DT
cord-018572-e2qq4ngq	315	2	fact	fact	NN
cord-018572-e2qq4ngq	315	3	that	that	IN
cord-018572-e2qq4ngq	315	4	Arf6-GTP	arf6-gtp	NN
cord-018572-e2qq4ngq	315	5	can	can	MD
cord-018572-e2qq4ngq	315	6	activate	activate	VB
cord-018572-e2qq4ngq	315	7	cytoshesin	cytoshesin	NNP
cord-018572-e2qq4ngq	315	8	/	/	SYM
cord-018572-e2qq4ngq	315	9	Arno	Arno	NNP
cord-018572-e2qq4ngq	315	10	,	,	,
cord-018572-e2qq4ngq	315	11	that	that	IN
cord-018572-e2qq4ngq	315	12	the	the	DT
cord-018572-e2qq4ngq	315	13	capacity	capacity	NN
cord-018572-e2qq4ngq	315	14	to	to	TO
cord-018572-e2qq4ngq	315	15	activate	activate	VB
cord-018572-e2qq4ngq	315	16	this	this	DT
cord-018572-e2qq4ngq	315	17	GEF	GEF	NNP
cord-018572-e2qq4ngq	315	18	is	be	VBZ
cord-018572-e2qq4ngq	315	19	highly	highly	RB
cord-018572-e2qq4ngq	315	20	dependent	dependent	JJ
cord-018572-e2qq4ngq	315	21	on	on	IN
cord-018572-e2qq4ngq	315	22	relative	relative	JJ
cord-018572-e2qq4ngq	315	23	levels	level	NNS
cord-018572-e2qq4ngq	315	24	of	of	IN
cord-018572-e2qq4ngq	315	25	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	315	26	/	/	SYM
cord-018572-e2qq4ngq	315	27	Arno	Arno	NNP
cord-018572-e2qq4ngq	315	28	and	and	CC
cord-018572-e2qq4ngq	315	29	effectors	effector	NNS
cord-018572-e2qq4ngq	315	30	,	,	,
cord-018572-e2qq4ngq	315	31	and	and	CC
cord-018572-e2qq4ngq	315	32	that	that	IN
cord-018572-e2qq4ngq	315	33	both	both	DT
cord-018572-e2qq4ngq	315	34	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	315	35	and	and	CC
cord-018572-e2qq4ngq	315	36	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	316	1	positive	positive	JJ
cord-018572-e2qq4ngq	316	2	feedback	feedback	NN
cord-018572-e2qq4ngq	316	3	loops	loop	NNS
cord-018572-e2qq4ngq	316	4	exist	exist	VBP
cord-018572-e2qq4ngq	316	5	,	,	,
cord-018572-e2qq4ngq	316	6	all	all	DT
cord-018572-e2qq4ngq	316	7	need	need	VBP
cord-018572-e2qq4ngq	316	8	to	to	TO
cord-018572-e2qq4ngq	316	9	be	be	VB
cord-018572-e2qq4ngq	316	10	taken	take	VBN
cord-018572-e2qq4ngq	316	11	into	into	IN
cord-018572-e2qq4ngq	316	12	consideration	consideration	NN
cord-018572-e2qq4ngq	316	13	in	in	IN
cord-018572-e2qq4ngq	316	14	evaluating	evaluate	VBG
cord-018572-e2qq4ngq	316	15	in	in	IN
cord-018572-e2qq4ngq	316	16	vivo	vivo	NN
cord-018572-e2qq4ngq	316	17	results	result	NNS
cord-018572-e2qq4ngq	316	18	.	.	.
cord-018572-e2qq4ngq	317	1	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	317	2	is	be	VBZ
cord-018572-e2qq4ngq	317	3	required	require	VBN
cord-018572-e2qq4ngq	317	4	for	for	IN
cord-018572-e2qq4ngq	317	5	specific	specific	JJ
cord-018572-e2qq4ngq	317	6	processes	process	NNS
cord-018572-e2qq4ngq	317	7	at	at	IN
cord-018572-e2qq4ngq	317	8	the	the	DT
cord-018572-e2qq4ngq	317	9	PM	pm	NN
cord-018572-e2qq4ngq	317	10	such	such	JJ
cord-018572-e2qq4ngq	317	11	as	as	IN
cord-018572-e2qq4ngq	317	12	recruitment	recruitment	NN
cord-018572-e2qq4ngq	317	13	of	of	IN
cord-018572-e2qq4ngq	317	14	proteins	protein	NNS
cord-018572-e2qq4ngq	317	15	to	to	IN
cord-018572-e2qq4ngq	317	16	focal	focal	JJ
cord-018572-e2qq4ngq	317	17	adhesions	adhesion	NNS
cord-018572-e2qq4ngq	317	18	and	and	CC
cord-018572-e2qq4ngq	317	19	in	in	IN
cord-018572-e2qq4ngq	317	20	phagocytosis	phagocytosis	NN
cord-018572-e2qq4ngq	317	21	,	,	,
cord-018572-e2qq4ngq	317	22	and	and	CC
cord-018572-e2qq4ngq	317	23	Arf1-GTP	Arf1-GTP	VBZ
cord-018572-e2qq4ngq	317	24	localizes	localize	VBZ
cord-018572-e2qq4ngq	317	25	to	to	IN
cord-018572-e2qq4ngq	317	26	these	these	DT
cord-018572-e2qq4ngq	317	27	sites	site	NNS
cord-018572-e2qq4ngq	317	28	(	(	-LRB-
cord-018572-e2qq4ngq	317	29	Beemiller	Beemiller	NNP
cord-018572-e2qq4ngq	317	30	et	et	NNP
cord-018572-e2qq4ngq	317	31	al	al	NNP
cord-018572-e2qq4ngq	317	32	.	.	.
cord-018572-e2qq4ngq	317	33	2006	2006	CD
cord-018572-e2qq4ngq	317	34	;	;	:
cord-018572-e2qq4ngq	317	35	Furman	Furman	NNP
cord-018572-e2qq4ngq	317	36	et	et	NNP
cord-018572-e2qq4ngq	317	37	al	al	NNP
cord-018572-e2qq4ngq	317	38	.	.	.
cord-018572-e2qq4ngq	317	39	2002	2002	CD
cord-018572-e2qq4ngq	318	1	;	;	:
cord-018572-e2qq4ngq	318	2	Kruljac	Kruljac	NNP
cord-018572-e2qq4ngq	318	3	-	-	HYPH
cord-018572-e2qq4ngq	318	4	Letunic	Letunic	NNP
cord-018572-e2qq4ngq	318	5	et	et	FW
cord-018572-e2qq4ngq	318	6	al	al	NNP
cord-018572-e2qq4ngq	318	7	.	.	.
cord-018572-e2qq4ngq	319	1	2003	2003	CD
cord-018572-e2qq4ngq	319	2	;	;	:
cord-018572-e2qq4ngq	319	3	Norman	Norman	NNP
cord-018572-e2qq4ngq	319	4	et	et	NNP
cord-018572-e2qq4ngq	319	5	al	al	NNP
cord-018572-e2qq4ngq	319	6	.	.	NNP
cord-018572-e2qq4ngq	319	7	1998	1998	CD
cord-018572-e2qq4ngq	319	8	)	)	-RRB-
cord-018572-e2qq4ngq	319	9	.	.	.
cord-018572-e2qq4ngq	320	1	In	in	IN
cord-018572-e2qq4ngq	320	2	the	the	DT
cord-018572-e2qq4ngq	320	3	forming	form	VBG
cord-018572-e2qq4ngq	320	4	phagocytic	phagocytic	JJ
cord-018572-e2qq4ngq	320	5	cup	cup	NN
cord-018572-e2qq4ngq	320	6	,	,	,
cord-018572-e2qq4ngq	320	7	Arf6-GTP	Arf6-GTP	NNP
cord-018572-e2qq4ngq	320	8	is	be	VBZ
cord-018572-e2qq4ngq	320	9	recruited	recruit	VBN
cord-018572-e2qq4ngq	320	10	early	early	RB
cord-018572-e2qq4ngq	320	11	,	,	,
cord-018572-e2qq4ngq	320	12	followed	follow	VBN
cord-018572-e2qq4ngq	320	13	by	by	IN
cord-018572-e2qq4ngq	320	14	Arf1-GTP	arf1-gtp	NN
cord-018572-e2qq4ngq	320	15	,	,	,
cord-018572-e2qq4ngq	320	16	at	at	IN
cord-018572-e2qq4ngq	320	17	a	a	DT
cord-018572-e2qq4ngq	320	18	stage	stage	NN
cord-018572-e2qq4ngq	320	19	that	that	WDT
cord-018572-e2qq4ngq	320	20	requires	require	VBZ
cord-018572-e2qq4ngq	320	21	rapid	rapid	JJ
cord-018572-e2qq4ngq	320	22	insertion	insertion	NN
cord-018572-e2qq4ngq	320	23	of	of	IN
cord-018572-e2qq4ngq	320	24	new	new	JJ
cord-018572-e2qq4ngq	320	25	membrane	membrane	NN
cord-018572-e2qq4ngq	320	26	.	.	.
cord-018572-e2qq4ngq	321	1	These	these	DT
cord-018572-e2qq4ngq	321	2	results	result	NNS
cord-018572-e2qq4ngq	321	3	support	support	VBP
cord-018572-e2qq4ngq	321	4	the	the	DT
cord-018572-e2qq4ngq	321	5	idea	idea	NN
cord-018572-e2qq4ngq	321	6	that	that	IN
cord-018572-e2qq4ngq	321	7	the	the	DT
cord-018572-e2qq4ngq	321	8	Arf6-cytohesin	Arf6-cytohesin	NNP
cord-018572-e2qq4ngq	321	9	-	-	HYPH
cord-018572-e2qq4ngq	321	10	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	321	11	cascade	cascade	NN
cord-018572-e2qq4ngq	321	12	may	may	MD
cord-018572-e2qq4ngq	321	13	play	play	VB
cord-018572-e2qq4ngq	321	14	an	an	DT
cord-018572-e2qq4ngq	321	15	important	important	JJ
cord-018572-e2qq4ngq	321	16	role	role	NN
cord-018572-e2qq4ngq	321	17	in	in	IN
cord-018572-e2qq4ngq	321	18	processes	process	NNS
cord-018572-e2qq4ngq	321	19	that	that	WDT
cord-018572-e2qq4ngq	321	20	require	require	VBP
cord-018572-e2qq4ngq	321	21	a	a	DT
cord-018572-e2qq4ngq	321	22	high	high	JJ
cord-018572-e2qq4ngq	321	23	level	level	NN
cord-018572-e2qq4ngq	321	24	of	of	IN
cord-018572-e2qq4ngq	321	25	Arf	Arf	NNP
cord-018572-e2qq4ngq	321	26	protein	protein	NN
cord-018572-e2qq4ngq	321	27	.	.	.
cord-018572-e2qq4ngq	322	1	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	322	2	is	be	VBZ
cord-018572-e2qq4ngq	322	3	less	less	RBR
cord-018572-e2qq4ngq	322	4	abundant	abundant	JJ
cord-018572-e2qq4ngq	322	5	than	than	IN
cord-018572-e2qq4ngq	322	6	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	322	7	in	in	IN
cord-018572-e2qq4ngq	322	8	cells	cell	NNS
cord-018572-e2qq4ngq	322	9	,	,	,
cord-018572-e2qq4ngq	322	10	and	and	CC
cord-018572-e2qq4ngq	322	11	since	since	IN
cord-018572-e2qq4ngq	322	12	both	both	CC
cord-018572-e2qq4ngq	322	13	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	322	14	and	and	CC
cord-018572-e2qq4ngq	322	15	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	322	16	can	can	MD
cord-018572-e2qq4ngq	322	17	recruit	recruit	VB
cord-018572-e2qq4ngq	322	18	effectors	effector	NNS
cord-018572-e2qq4ngq	322	19	such	such	JJ
cord-018572-e2qq4ngq	322	20	as	as	IN
cord-018572-e2qq4ngq	322	21	PI4P	PI4P	NNP
cord-018572-e2qq4ngq	322	22	5	5	CD
cord-018572-e2qq4ngq	322	23	kinase	kinase	NNS
cord-018572-e2qq4ngq	322	24	and	and	CC
cord-018572-e2qq4ngq	322	25	PLD	PLD	NNP
cord-018572-e2qq4ngq	322	26	,	,	,
cord-018572-e2qq4ngq	322	27	processes	process	VBZ
cord-018572-e2qq4ngq	322	28	requiring	require	VBG
cord-018572-e2qq4ngq	322	29	an	an	DT
cord-018572-e2qq4ngq	322	30	acute	acute	JJ
cord-018572-e2qq4ngq	322	31	activation	activation	NN
cord-018572-e2qq4ngq	322	32	of	of	IN
cord-018572-e2qq4ngq	322	33	such	such	JJ
cord-018572-e2qq4ngq	322	34	effectors	effector	NNS
cord-018572-e2qq4ngq	322	35	may	may	MD
cord-018572-e2qq4ngq	322	36	rely	rely	VB
cord-018572-e2qq4ngq	322	37	on	on	IN
cord-018572-e2qq4ngq	322	38	the	the	DT
cord-018572-e2qq4ngq	322	39	more	more	RBR
cord-018572-e2qq4ngq	322	40	abundant	abundant	JJ
cord-018572-e2qq4ngq	322	41	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	322	42	to	to	TO
cord-018572-e2qq4ngq	322	43	provide	provide	VB
cord-018572-e2qq4ngq	322	44	an	an	DT
cord-018572-e2qq4ngq	322	45	adequate	adequate	JJ
cord-018572-e2qq4ngq	322	46	supply	supply	NN
cord-018572-e2qq4ngq	322	47	.	.	.
cord-018572-e2qq4ngq	323	1	Another	another	DT
cord-018572-e2qq4ngq	323	2	process	process	NN
cord-018572-e2qq4ngq	323	3	in	in	IN
cord-018572-e2qq4ngq	323	4	which	which	WDT
cord-018572-e2qq4ngq	323	5	this	this	DT
cord-018572-e2qq4ngq	323	6	mechanism	mechanism	NN
cord-018572-e2qq4ngq	323	7	may	may	MD
cord-018572-e2qq4ngq	323	8	operate	operate	VB
cord-018572-e2qq4ngq	323	9	is	be	VBZ
cord-018572-e2qq4ngq	323	10	in	in	IN
cord-018572-e2qq4ngq	323	11	the	the	DT
cord-018572-e2qq4ngq	323	12	insulin	insulin	NN
cord-018572-e2qq4ngq	323	13	signalling	signal	VBG
cord-018572-e2qq4ngq	323	14	pathway	pathway	NN
cord-018572-e2qq4ngq	323	15	,	,	,
cord-018572-e2qq4ngq	323	16	where	where	WRB
cord-018572-e2qq4ngq	323	17	both	both	CC
cord-018572-e2qq4ngq	323	18	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	323	19	and	and	CC
cord-018572-e2qq4ngq	323	20	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	323	21	were	be	VBD
cord-018572-e2qq4ngq	323	22	shown	show	VBN
cord-018572-e2qq4ngq	323	23	to	to	TO
cord-018572-e2qq4ngq	323	24	contribute	contribute	VB
cord-018572-e2qq4ngq	323	25	to	to	IN
cord-018572-e2qq4ngq	323	26	activation	activation	NN
cord-018572-e2qq4ngq	323	27	of	of	IN
cord-018572-e2qq4ngq	323	28	PI4P	PI4P	NNP
cord-018572-e2qq4ngq	323	29	5	5	CD
cord-018572-e2qq4ngq	323	30	kinase	kinase	NNS
cord-018572-e2qq4ngq	323	31	and	and	CC
cord-018572-e2qq4ngq	323	32	PLD	PLD	NNP
cord-018572-e2qq4ngq	323	33	by	by	IN
cord-018572-e2qq4ngq	323	34	cytohesin-2	cytohesin-2	NNP
cord-018572-e2qq4ngq	323	35	/	/	SYM
cord-018572-e2qq4ngq	323	36	Arno	Arno	NNP
cord-018572-e2qq4ngq	324	1	(	(	-LRB-
cord-018572-e2qq4ngq	324	2	Lim	Lim	NNP
cord-018572-e2qq4ngq	324	3	et	et	NNP
cord-018572-e2qq4ngq	324	4	al	al	NNP
cord-018572-e2qq4ngq	324	5	.	.	NNP
cord-018572-e2qq4ngq	324	6	2010	2010	CD
cord-018572-e2qq4ngq	324	7	)	)	-RRB-
cord-018572-e2qq4ngq	324	8	.	.	.
cord-018572-e2qq4ngq	325	1	The	the	DT
cord-018572-e2qq4ngq	325	2	implication	implication	NN
cord-018572-e2qq4ngq	325	3	of	of	IN
cord-018572-e2qq4ngq	325	4	Arf	Arf	NNP
cord-018572-e2qq4ngq	325	5	proteins	protein	NNS
cord-018572-e2qq4ngq	325	6	and	and	CC
cord-018572-e2qq4ngq	325	7	their	-PRON-	PRP$
cord-018572-e2qq4ngq	325	8	GEFs	gef	NNS
cord-018572-e2qq4ngq	325	9	and	and	CC
cord-018572-e2qq4ngq	325	10	GAPs	gaps	NN
cord-018572-e2qq4ngq	325	11	in	in	IN
cord-018572-e2qq4ngq	325	12	human	human	JJ
cord-018572-e2qq4ngq	325	13	pathologies	pathology	NNS
cord-018572-e2qq4ngq	325	14	is	be	VBZ
cord-018572-e2qq4ngq	325	15	a	a	DT
cord-018572-e2qq4ngq	325	16	rapidly	rapidly	RB
cord-018572-e2qq4ngq	325	17	expanding	expand	VBG
cord-018572-e2qq4ngq	325	18	area	area	NN
cord-018572-e2qq4ngq	325	19	.	.	.
cord-018572-e2qq4ngq	326	1	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	326	2	and	and	CC
cord-018572-e2qq4ngq	326	3	their	-PRON-	PRP$
cord-018572-e2qq4ngq	326	4	regulators	regulator	NNS
cord-018572-e2qq4ngq	326	5	have	have	VBP
cord-018572-e2qq4ngq	326	6	been	be	VBN
cord-018572-e2qq4ngq	326	7	linked	link	VBN
cord-018572-e2qq4ngq	326	8	to	to	IN
cord-018572-e2qq4ngq	326	9	neurodevelopmental	neurodevelopmental	JJ
cord-018572-e2qq4ngq	326	10	disorders	disorder	NNS
cord-018572-e2qq4ngq	326	11	,	,	,
cord-018572-e2qq4ngq	326	12	neurodegenerative	neurodegenerative	JJ
cord-018572-e2qq4ngq	326	13	diseases	disease	NNS
cord-018572-e2qq4ngq	326	14	,	,	,
cord-018572-e2qq4ngq	326	15	cancers	cancer	NNS
cord-018572-e2qq4ngq	326	16	,	,	,
cord-018572-e2qq4ngq	326	17	and	and	CC
cord-018572-e2qq4ngq	326	18	both	both	DT
cord-018572-e2qq4ngq	326	19	viral	viral	JJ
cord-018572-e2qq4ngq	326	20	and	and	CC
cord-018572-e2qq4ngq	326	21	bacterial	bacterial	JJ
cord-018572-e2qq4ngq	326	22	infections	infection	NNS
cord-018572-e2qq4ngq	326	23	.	.	.
cord-018572-e2qq4ngq	327	1	Here	here	RB
cord-018572-e2qq4ngq	327	2	,	,	,
cord-018572-e2qq4ngq	327	3	I	-PRON-	PRP
cord-018572-e2qq4ngq	327	4	will	will	MD
cord-018572-e2qq4ngq	327	5	describe	describe	VB
cord-018572-e2qq4ngq	327	6	examples	example	NNS
cord-018572-e2qq4ngq	327	7	of	of	IN
cord-018572-e2qq4ngq	327	8	their	-PRON-	PRP$
cord-018572-e2qq4ngq	327	9	roles	role	NNS
cord-018572-e2qq4ngq	327	10	in	in	IN
cord-018572-e2qq4ngq	327	11	human	human	JJ
cord-018572-e2qq4ngq	327	12	disorders	disorder	NNS
cord-018572-e2qq4ngq	327	13	,	,	,
cord-018572-e2qq4ngq	327	14	and	and	CC
cord-018572-e2qq4ngq	327	15	the	the	DT
cord-018572-e2qq4ngq	327	16	reader	reader	NN
cord-018572-e2qq4ngq	327	17	is	be	VBZ
cord-018572-e2qq4ngq	327	18	referred	refer	VBN
cord-018572-e2qq4ngq	327	19	to	to	IN
cord-018572-e2qq4ngq	327	20	other	other	JJ
cord-018572-e2qq4ngq	327	21	sources	source	NNS
cord-018572-e2qq4ngq	327	22	for	for	IN
cord-018572-e2qq4ngq	327	23	a	a	DT
cord-018572-e2qq4ngq	327	24	more	more	RBR
cord-018572-e2qq4ngq	327	25	comprehensive	comprehensive	JJ
cord-018572-e2qq4ngq	327	26	description	description	NN
cord-018572-e2qq4ngq	327	27	of	of	IN
cord-018572-e2qq4ngq	327	28	specific	specific	JJ
cord-018572-e2qq4ngq	327	29	topics	topic	NNS
cord-018572-e2qq4ngq	327	30	in	in	IN
cord-018572-e2qq4ngq	327	31	this	this	DT
cord-018572-e2qq4ngq	327	32	growing	grow	VBG
cord-018572-e2qq4ngq	327	33	field	field	NN
cord-018572-e2qq4ngq	327	34	(	(	-LRB-
cord-018572-e2qq4ngq	327	35	Dani	Dani	NNP
cord-018572-e2qq4ngq	327	36	et	et	FW
cord-018572-e2qq4ngq	327	37	al	al	NNP
cord-018572-e2qq4ngq	327	38	.	.	.
cord-018572-e2qq4ngq	328	1	2013	2013	CD
cord-018572-e2qq4ngq	328	2	;	;	:
cord-018572-e2qq4ngq	328	3	Lovrecic	Lovrecic	NNP
cord-018572-e2qq4ngq	328	4	et	et	NNP
cord-018572-e2qq4ngq	328	5	al	al	NNP
cord-018572-e2qq4ngq	328	6	.	.	.
cord-018572-e2qq4ngq	328	7	2010	2010	CD
cord-018572-e2qq4ngq	329	1	;	;	:
cord-018572-e2qq4ngq	329	2	Poincloux	Poincloux	NNP
cord-018572-e2qq4ngq	329	3	et	et	NNP
cord-018572-e2qq4ngq	329	4	al	al	NNP
cord-018572-e2qq4ngq	329	5	.	.	.
cord-018572-e2qq4ngq	329	6	2009	2009	CD
cord-018572-e2qq4ngq	329	7	;	;	:
cord-018572-e2qq4ngq	329	8	Sabe	Sabe	NNP
cord-018572-e2qq4ngq	329	9	et	et	FW
cord-018572-e2qq4ngq	329	10	al	al	NNP
cord-018572-e2qq4ngq	329	11	.	.	.
cord-018572-e2qq4ngq	330	1	2006	2006	CD
cord-018572-e2qq4ngq	331	1	Sabe	Sabe	NNP
cord-018572-e2qq4ngq	331	2	et	et	NNP
cord-018572-e2qq4ngq	331	3	al	al	NNP
cord-018572-e2qq4ngq	331	4	.	.	NNP
cord-018572-e2qq4ngq	331	5	,	,	,
cord-018572-e2qq4ngq	332	1	2009	2009	CD
cord-018572-e2qq4ngq	333	1	Seixas	Seixas	NNP
cord-018572-e2qq4ngq	333	2	et	et	NNP
cord-018572-e2qq4ngq	333	3	al	al	NNP
cord-018572-e2qq4ngq	333	4	.	.	.
cord-018572-e2qq4ngq	334	1	2013	2013	CD
cord-018572-e2qq4ngq	334	2	;	;	:
cord-018572-e2qq4ngq	334	3	Stafa	Stafa	NNP
cord-018572-e2qq4ngq	334	4	et	et	NNP
cord-018572-e2qq4ngq	334	5	al	al	NNP
cord-018572-e2qq4ngq	334	6	.	.	.
cord-018572-e2qq4ngq	335	1	2012	2012	CD
cord-018572-e2qq4ngq	335	2	;	;	:
cord-018572-e2qq4ngq	335	3	Tan	Tan	NNP
cord-018572-e2qq4ngq	335	4	and	and	CC
cord-018572-e2qq4ngq	335	5	Evin	Evin	NNP
cord-018572-e2qq4ngq	335	6	2012	2012	CD
cord-018572-e2qq4ngq	335	7	)	)	-RRB-
cord-018572-e2qq4ngq	335	8	.	.	.
cord-018572-e2qq4ngq	336	1	Mutations	mutation	NNS
cord-018572-e2qq4ngq	336	2	in	in	IN
cord-018572-e2qq4ngq	336	3	the	the	DT
cord-018572-e2qq4ngq	336	4	BIG2	BIG2	NNP
cord-018572-e2qq4ngq	337	1	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	337	2	GEF	GEF	NNP
cord-018572-e2qq4ngq	337	3	have	have	VBP
cord-018572-e2qq4ngq	337	4	been	be	VBN
cord-018572-e2qq4ngq	337	5	linked	link	VBN
cord-018572-e2qq4ngq	337	6	to	to	IN
cord-018572-e2qq4ngq	337	7	autosomal	autosomal	JJ
cord-018572-e2qq4ngq	337	8	recessive	recessive	JJ
cord-018572-e2qq4ngq	337	9	periventricular	periventricular	FW
cord-018572-e2qq4ngq	337	10	heterotopia	heterotopia	FW
cord-018572-e2qq4ngq	337	11	(	(	-LRB-
cord-018572-e2qq4ngq	337	12	ARPH	ARPH	NNP
cord-018572-e2qq4ngq	337	13	)	)	-RRB-
cord-018572-e2qq4ngq	337	14	,	,	,
cord-018572-e2qq4ngq	337	15	a	a	DT
cord-018572-e2qq4ngq	337	16	disorder	disorder	NN
cord-018572-e2qq4ngq	337	17	of	of	IN
cord-018572-e2qq4ngq	337	18	neuronal	neuronal	JJ
cord-018572-e2qq4ngq	337	19	migration	migration	NN
cord-018572-e2qq4ngq	337	20	that	that	WDT
cord-018572-e2qq4ngq	337	21	leads	lead	VBZ
cord-018572-e2qq4ngq	337	22	to	to	IN
cord-018572-e2qq4ngq	337	23	severe	severe	JJ
cord-018572-e2qq4ngq	337	24	malformation	malformation	NN
cord-018572-e2qq4ngq	337	25	of	of	IN
cord-018572-e2qq4ngq	337	26	the	the	DT
cord-018572-e2qq4ngq	337	27	cerebral	cerebral	JJ
cord-018572-e2qq4ngq	337	28	cortex	cortex	NNP
cord-018572-e2qq4ngq	337	29	(	(	-LRB-
cord-018572-e2qq4ngq	337	30	microcephaly	microcephaly	NNP
cord-018572-e2qq4ngq	337	31	)	)	-RRB-
cord-018572-e2qq4ngq	337	32	and	and	CC
cord-018572-e2qq4ngq	337	33	developmental	developmental	JJ
cord-018572-e2qq4ngq	337	34	delay	delay	NN
cord-018572-e2qq4ngq	337	35	(	(	-LRB-
cord-018572-e2qq4ngq	337	36	Sheen	Sheen	NNP
cord-018572-e2qq4ngq	337	37	et	et	NNP
cord-018572-e2qq4ngq	337	38	al	al	NNP
cord-018572-e2qq4ngq	337	39	.	.	.
cord-018572-e2qq4ngq	337	40	2004	2004	CD
cord-018572-e2qq4ngq	337	41	)	)	-RRB-
cord-018572-e2qq4ngq	337	42	.	.	.
cord-018572-e2qq4ngq	338	1	Two	two	CD
cord-018572-e2qq4ngq	338	2	mutations	mutation	NNS
cord-018572-e2qq4ngq	338	3	in	in	IN
cord-018572-e2qq4ngq	338	4	BIG2	BIG2	NNP
cord-018572-e2qq4ngq	338	5	have	have	VBP
cord-018572-e2qq4ngq	338	6	been	be	VBN
cord-018572-e2qq4ngq	338	7	identified	identify	VBN
cord-018572-e2qq4ngq	338	8	in	in	IN
cord-018572-e2qq4ngq	338	9	ARPH	ARPH	NNP
cord-018572-e2qq4ngq	338	10	patients	patient	NNS
cord-018572-e2qq4ngq	338	11	,	,	,
cord-018572-e2qq4ngq	338	12	one	one	CD
cord-018572-e2qq4ngq	338	13	of	of	IN
cord-018572-e2qq4ngq	338	14	which	which	WDT
cord-018572-e2qq4ngq	338	15	is	be	VBZ
cord-018572-e2qq4ngq	338	16	a	a	DT
cord-018572-e2qq4ngq	338	17	frame	frame	JJ
cord-018572-e2qq4ngq	338	18	shift	shift	NN
cord-018572-e2qq4ngq	338	19	mutation	mutation	NN
cord-018572-e2qq4ngq	338	20	that	that	WDT
cord-018572-e2qq4ngq	338	21	results	result	VBZ
cord-018572-e2qq4ngq	338	22	in	in	IN
cord-018572-e2qq4ngq	338	23	truncation	truncation	NN
cord-018572-e2qq4ngq	338	24	of	of	IN
cord-018572-e2qq4ngq	338	25	the	the	DT
cord-018572-e2qq4ngq	338	26	majority	majority	NN
cord-018572-e2qq4ngq	338	27	of	of	IN
cord-018572-e2qq4ngq	338	28	the	the	DT
cord-018572-e2qq4ngq	338	29	protein	protein	NN
cord-018572-e2qq4ngq	338	30	(	(	-LRB-
cord-018572-e2qq4ngq	338	31	Sheen	Sheen	NNP
cord-018572-e2qq4ngq	338	32	et	et	NNP
cord-018572-e2qq4ngq	338	33	al	al	NNP
cord-018572-e2qq4ngq	338	34	.	.	.
cord-018572-e2qq4ngq	338	35	2004	2004	CD
cord-018572-e2qq4ngq	338	36	)	)	-RRB-
cord-018572-e2qq4ngq	338	37	.	.	.
cord-018572-e2qq4ngq	339	1	The	the	DT
cord-018572-e2qq4ngq	339	2	disease	disease	NN
cord-018572-e2qq4ngq	339	3	symptoms	symptom	NNS
cord-018572-e2qq4ngq	339	4	are	be	VBP
cord-018572-e2qq4ngq	339	5	a	a	DT
cord-018572-e2qq4ngq	339	6	result	result	NN
cord-018572-e2qq4ngq	339	7	of	of	IN
cord-018572-e2qq4ngq	339	8	the	the	DT
cord-018572-e2qq4ngq	339	9	failure	failure	NN
cord-018572-e2qq4ngq	339	10	of	of	IN
cord-018572-e2qq4ngq	339	11	a	a	DT
cord-018572-e2qq4ngq	339	12	specific	specific	JJ
cord-018572-e2qq4ngq	339	13	class	class	NN
cord-018572-e2qq4ngq	339	14	of	of	IN
cord-018572-e2qq4ngq	339	15	neurons	neuron	NNS
cord-018572-e2qq4ngq	339	16	to	to	TO
cord-018572-e2qq4ngq	339	17	migrate	migrate	VB
cord-018572-e2qq4ngq	339	18	from	from	IN
cord-018572-e2qq4ngq	339	19	their	-PRON-	PRP$
cord-018572-e2qq4ngq	339	20	point	point	NN
cord-018572-e2qq4ngq	339	21	of	of	IN
cord-018572-e2qq4ngq	339	22	origin	origin	NN
cord-018572-e2qq4ngq	339	23	in	in	IN
cord-018572-e2qq4ngq	339	24	the	the	DT
cord-018572-e2qq4ngq	339	25	lateral	lateral	JJ
cord-018572-e2qq4ngq	339	26	ventricular	ventricular	JJ
cord-018572-e2qq4ngq	339	27	proliferative	proliferative	JJ
cord-018572-e2qq4ngq	339	28	zone	zone	NN
cord-018572-e2qq4ngq	339	29	to	to	IN
cord-018572-e2qq4ngq	339	30	the	the	DT
cord-018572-e2qq4ngq	339	31	cerebral	cerebral	JJ
cord-018572-e2qq4ngq	339	32	cortex	cortex	NN
cord-018572-e2qq4ngq	340	1	(	(	-LRB-
cord-018572-e2qq4ngq	340	2	Ferland	Ferland	NNP
cord-018572-e2qq4ngq	340	3	et	et	NNP
cord-018572-e2qq4ngq	340	4	al	al	NNP
cord-018572-e2qq4ngq	340	5	.	.	.
cord-018572-e2qq4ngq	340	6	2009	2009	CD
cord-018572-e2qq4ngq	340	7	;	;	:
cord-018572-e2qq4ngq	340	8	Sheen	Sheen	NNP
cord-018572-e2qq4ngq	340	9	et	et	NNP
cord-018572-e2qq4ngq	340	10	al	al	NNP
cord-018572-e2qq4ngq	340	11	.	.	.
cord-018572-e2qq4ngq	340	12	2004	2004	CD
cord-018572-e2qq4ngq	340	13	)	)	-RRB-
cord-018572-e2qq4ngq	340	14	.	.	.
cord-018572-e2qq4ngq	341	1	This	this	DT
cord-018572-e2qq4ngq	341	2	defect	defect	NN
cord-018572-e2qq4ngq	341	3	arises	arise	VBZ
cord-018572-e2qq4ngq	341	4	from	from	IN
cord-018572-e2qq4ngq	341	5	a	a	DT
cord-018572-e2qq4ngq	341	6	defect	defect	NN
cord-018572-e2qq4ngq	341	7	in	in	IN
cord-018572-e2qq4ngq	341	8	vesicular	vesicular	JJ
cord-018572-e2qq4ngq	341	9	trafficking	trafficking	NN
cord-018572-e2qq4ngq	341	10	that	that	WDT
cord-018572-e2qq4ngq	341	11	alters	alter	VBZ
cord-018572-e2qq4ngq	341	12	the	the	DT
cord-018572-e2qq4ngq	341	13	adhesion	adhesion	NN
cord-018572-e2qq4ngq	341	14	properties	property	NNS
cord-018572-e2qq4ngq	341	15	of	of	IN
cord-018572-e2qq4ngq	341	16	these	these	DT
cord-018572-e2qq4ngq	341	17	neurons	neuron	NNS
cord-018572-e2qq4ngq	341	18	(	(	-LRB-
cord-018572-e2qq4ngq	341	19	Ferland	Ferland	NNP
cord-018572-e2qq4ngq	341	20	et	et	NNP
cord-018572-e2qq4ngq	341	21	al	al	NNP
cord-018572-e2qq4ngq	341	22	.	.	.
cord-018572-e2qq4ngq	341	23	2009	2009	CD
cord-018572-e2qq4ngq	341	24	)	)	-RRB-
cord-018572-e2qq4ngq	341	25	.	.	.
cord-018572-e2qq4ngq	342	1	In	in	IN
cord-018572-e2qq4ngq	342	2	addition	addition	NN
cord-018572-e2qq4ngq	342	3	to	to	IN
cord-018572-e2qq4ngq	342	4	BIG2	BIG2	NNP
cord-018572-e2qq4ngq	342	5	,	,	,
cord-018572-e2qq4ngq	342	6	mutations	mutation	NNS
cord-018572-e2qq4ngq	342	7	in	in	IN
cord-018572-e2qq4ngq	342	8	the	the	DT
cord-018572-e2qq4ngq	342	9	gene	gene	NN
cord-018572-e2qq4ngq	342	10	encoding	encode	VBG
cord-018572-e2qq4ngq	342	11	filamin	filamin	NNP
cord-018572-e2qq4ngq	342	12	A	A	NNP
cord-018572-e2qq4ngq	342	13	also	also	RB
cord-018572-e2qq4ngq	342	14	cause	cause	VB
cord-018572-e2qq4ngq	342	15	ARPH	ARPH	NNP
cord-018572-e2qq4ngq	342	16	.	.	.
cord-018572-e2qq4ngq	343	1	A	a	DT
cord-018572-e2qq4ngq	343	2	recent	recent	JJ
cord-018572-e2qq4ngq	343	3	study	study	NN
cord-018572-e2qq4ngq	343	4	has	have	VBZ
cord-018572-e2qq4ngq	343	5	found	find	VBN
cord-018572-e2qq4ngq	343	6	a	a	DT
cord-018572-e2qq4ngq	343	7	mechanistic	mechanistic	JJ
cord-018572-e2qq4ngq	343	8	connection	connection	NN
cord-018572-e2qq4ngq	343	9	between	between	IN
cord-018572-e2qq4ngq	343	10	these	these	DT
cord-018572-e2qq4ngq	343	11	two	two	CD
cord-018572-e2qq4ngq	343	12	proteins	protein	NNS
cord-018572-e2qq4ngq	343	13	in	in	IN
cord-018572-e2qq4ngq	343	14	a	a	DT
cord-018572-e2qq4ngq	343	15	mouse	mouse	NN
cord-018572-e2qq4ngq	343	16	model	model	NN
cord-018572-e2qq4ngq	343	17	of	of	IN
cord-018572-e2qq4ngq	343	18	the	the	DT
cord-018572-e2qq4ngq	343	19	disease	disease	NN
cord-018572-e2qq4ngq	343	20	(	(	-LRB-
cord-018572-e2qq4ngq	343	21	Zhang	Zhang	NNP
cord-018572-e2qq4ngq	343	22	et	et	NNP
cord-018572-e2qq4ngq	343	23	al	al	NNP
cord-018572-e2qq4ngq	343	24	.	.	NNP
cord-018572-e2qq4ngq	343	25	2013	2013	CD
cord-018572-e2qq4ngq	343	26	)	)	-RRB-
cord-018572-e2qq4ngq	343	27	.	.	.
cord-018572-e2qq4ngq	344	1	The	the	DT
cord-018572-e2qq4ngq	344	2	IQSEC	IQSEC	NNP
cord-018572-e2qq4ngq	344	3	/	/	SYM
cord-018572-e2qq4ngq	344	4	BRAG	brag	VBP
cord-018572-e2qq4ngq	344	5	Arf	Arf	NNP
cord-018572-e2qq4ngq	344	6	GEFs	gef	NNS
cord-018572-e2qq4ngq	344	7	are	be	VBP
cord-018572-e2qq4ngq	344	8	highly	highly	RB
cord-018572-e2qq4ngq	344	9	expressed	express	VBN
cord-018572-e2qq4ngq	344	10	in	in	IN
cord-018572-e2qq4ngq	344	11	the	the	DT
cord-018572-e2qq4ngq	344	12	postsynaptic	postsynaptic	JJ
cord-018572-e2qq4ngq	344	13	density	density	NN
cord-018572-e2qq4ngq	344	14	of	of	IN
cord-018572-e2qq4ngq	344	15	the	the	DT
cord-018572-e2qq4ngq	344	16	central	central	JJ
cord-018572-e2qq4ngq	344	17	nervous	nervous	JJ
cord-018572-e2qq4ngq	344	18	system	system	NN
cord-018572-e2qq4ngq	344	19	(	(	-LRB-
cord-018572-e2qq4ngq	344	20	Casanova	Casanova	NNP
cord-018572-e2qq4ngq	344	21	2007	2007	CD
cord-018572-e2qq4ngq	344	22	)	)	-RRB-
cord-018572-e2qq4ngq	344	23	,	,	,
cord-018572-e2qq4ngq	344	24	and	and	CC
cord-018572-e2qq4ngq	344	25	play	play	VB
cord-018572-e2qq4ngq	344	26	important	important	JJ
cord-018572-e2qq4ngq	344	27	roles	role	NNS
cord-018572-e2qq4ngq	344	28	in	in	IN
cord-018572-e2qq4ngq	344	29	signalling	signal	VBG
cord-018572-e2qq4ngq	344	30	during	during	IN
cord-018572-e2qq4ngq	344	31	synaptic	synaptic	JJ
cord-018572-e2qq4ngq	344	32	transmission	transmission	NN
cord-018572-e2qq4ngq	344	33	(	(	-LRB-
cord-018572-e2qq4ngq	344	34	Myers	Myers	NNP
cord-018572-e2qq4ngq	344	35	et	et	NNP
cord-018572-e2qq4ngq	344	36	al	al	NNP
cord-018572-e2qq4ngq	344	37	.	.	NNP
cord-018572-e2qq4ngq	344	38	2012	2012	CD
cord-018572-e2qq4ngq	344	39	)	)	-RRB-
cord-018572-e2qq4ngq	344	40	.	.	.
cord-018572-e2qq4ngq	345	1	This	this	DT
cord-018572-e2qq4ngq	345	2	family	family	NN
cord-018572-e2qq4ngq	345	3	of	of	IN
cord-018572-e2qq4ngq	345	4	Arf	Arf	NNP
cord-018572-e2qq4ngq	345	5	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	345	6	use	use	VBP
cord-018572-e2qq4ngq	345	7	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	345	8	as	as	IN
cord-018572-e2qq4ngq	345	9	a	a	DT
cord-018572-e2qq4ngq	345	10	substrate	substrate	NN
cord-018572-e2qq4ngq	345	11	,	,	,
cord-018572-e2qq4ngq	345	12	but	but	CC
cord-018572-e2qq4ngq	345	13	can	can	MD
cord-018572-e2qq4ngq	345	14	also	also	RB
cord-018572-e2qq4ngq	345	15	act	act	VB
cord-018572-e2qq4ngq	345	16	on	on	IN
cord-018572-e2qq4ngq	345	17	Arf5	Arf5	NNP
cord-018572-e2qq4ngq	345	18	(	(	-LRB-
cord-018572-e2qq4ngq	345	19	Moravec	Moravec	NNP
cord-018572-e2qq4ngq	345	20	et	et	NNP
cord-018572-e2qq4ngq	345	21	al	al	NNP
cord-018572-e2qq4ngq	345	22	.	.	NNP
cord-018572-e2qq4ngq	345	23	2012	2012	CD
cord-018572-e2qq4ngq	345	24	)	)	-RRB-
cord-018572-e2qq4ngq	345	25	.	.	.
cord-018572-e2qq4ngq	346	1	BRAG1/	brag1/	RB
cord-018572-e2qq4ngq	347	1	IQSEC2	IQSEC2	NNP
cord-018572-e2qq4ngq	347	2	is	be	VBZ
cord-018572-e2qq4ngq	347	3	mutated	mutate	VBN
cord-018572-e2qq4ngq	347	4	in	in	IN
cord-018572-e2qq4ngq	347	5	X	x	NN
cord-018572-e2qq4ngq	347	6	-	-	HYPH
cord-018572-e2qq4ngq	347	7	linked	link	VBN
cord-018572-e2qq4ngq	347	8	nonsyndromic	nonsyndromic	NNP
cord-018572-e2qq4ngq	347	9	intellectual	intellectual	JJ
cord-018572-e2qq4ngq	347	10	disability	disability	NNP
cord-018572-e2qq4ngq	347	11	,	,	,
cord-018572-e2qq4ngq	347	12	a	a	DT
cord-018572-e2qq4ngq	347	13	form	form	NN
cord-018572-e2qq4ngq	347	14	of	of	IN
cord-018572-e2qq4ngq	347	15	mental	mental	JJ
cord-018572-e2qq4ngq	347	16	retardation	retardation	NN
cord-018572-e2qq4ngq	347	17	.	.	.
cord-018572-e2qq4ngq	348	1	Three	three	CD
cord-018572-e2qq4ngq	348	2	point	point	NN
cord-018572-e2qq4ngq	348	3	mutations	mutation	NNS
cord-018572-e2qq4ngq	348	4	isolated	isolate	VBN
cord-018572-e2qq4ngq	348	5	from	from	IN
cord-018572-e2qq4ngq	348	6	patients	patient	NNS
cord-018572-e2qq4ngq	348	7	map	map	VBP
cord-018572-e2qq4ngq	348	8	to	to	IN
cord-018572-e2qq4ngq	348	9	the	the	DT
cord-018572-e2qq4ngq	348	10	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	348	11	domain	domain	NN
cord-018572-e2qq4ngq	348	12	and	and	CC
cord-018572-e2qq4ngq	348	13	result	result	NN
cord-018572-e2qq4ngq	348	14	in	in	IN
cord-018572-e2qq4ngq	348	15	proteins	protein	NNS
cord-018572-e2qq4ngq	348	16	that	that	WDT
cord-018572-e2qq4ngq	348	17	can	can	MD
cord-018572-e2qq4ngq	348	18	not	not	RB
cord-018572-e2qq4ngq	348	19	activate	activate	VB
cord-018572-e2qq4ngq	348	20	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	348	21	normally	normally	RB
cord-018572-e2qq4ngq	348	22	(	(	-LRB-
cord-018572-e2qq4ngq	348	23	Shoubridge	Shoubridge	NNP
cord-018572-e2qq4ngq	348	24	et	et	NNP
cord-018572-e2qq4ngq	348	25	al	al	NNP
cord-018572-e2qq4ngq	348	26	.	.	.
cord-018572-e2qq4ngq	349	1	2010a	2010a	NNS
cord-018572-e2qq4ngq	349	2	,	,	,
cord-018572-e2qq4ngq	349	3	b	b	LS
cord-018572-e2qq4ngq	349	4	)	)	-RRB-
cord-018572-e2qq4ngq	349	5	.	.	.
cord-018572-e2qq4ngq	350	1	BRAG2	BRAG2	NNP
cord-018572-e2qq4ngq	350	2	has	have	VBZ
cord-018572-e2qq4ngq	350	3	been	be	VBN
cord-018572-e2qq4ngq	350	4	linked	link	VBN
cord-018572-e2qq4ngq	350	5	to	to	IN
cord-018572-e2qq4ngq	350	6	alterations	alteration	NNS
cord-018572-e2qq4ngq	350	7	in	in	IN
cord-018572-e2qq4ngq	350	8	synaptic	synaptic	JJ
cord-018572-e2qq4ngq	350	9	content	content	NN
cord-018572-e2qq4ngq	350	10	during	during	IN
cord-018572-e2qq4ngq	350	11	long	long	JJ
cord-018572-e2qq4ngq	350	12	-	-	HYPH
cord-018572-e2qq4ngq	350	13	term	term	NN
cord-018572-e2qq4ngq	350	14	depression	depression	NN
cord-018572-e2qq4ngq	350	15	(	(	-LRB-
cord-018572-e2qq4ngq	350	16	LTD	LTD	NNP
cord-018572-e2qq4ngq	350	17	)	)	-RRB-
cord-018572-e2qq4ngq	350	18	.	.	.
cord-018572-e2qq4ngq	351	1	Signalling	signal	VBG
cord-018572-e2qq4ngq	351	2	through	through	IN
cord-018572-e2qq4ngq	351	3	AMPA	ampa	NN
cord-018572-e2qq4ngq	351	4	-	-	HYPH
cord-018572-e2qq4ngq	351	5	type	type	NN
cord-018572-e2qq4ngq	351	6	glutamate	glutamate	NN
cord-018572-e2qq4ngq	351	7	receptors	receptor	NNS
cord-018572-e2qq4ngq	351	8	facilitates	facilitate	VBZ
cord-018572-e2qq4ngq	351	9	LTD	LTD	NNP
cord-018572-e2qq4ngq	351	10	,	,	,
cord-018572-e2qq4ngq	351	11	and	and	CC
cord-018572-e2qq4ngq	351	12	donwregulation	donwregulation	NN
cord-018572-e2qq4ngq	351	13	of	of	IN
cord-018572-e2qq4ngq	351	14	activated	activate	VBN
cord-018572-e2qq4ngq	351	15	AMPA	AMPA	NNP
cord-018572-e2qq4ngq	351	16	receptors	receptor	NNS
cord-018572-e2qq4ngq	351	17	is	be	VBZ
cord-018572-e2qq4ngq	351	18	normally	normally	RB
cord-018572-e2qq4ngq	351	19	regulated	regulate	VBN
cord-018572-e2qq4ngq	351	20	by	by	IN
cord-018572-e2qq4ngq	351	21	AMPA	AMPA	NNP
cord-018572-e2qq4ngq	351	22	receptor	receptor	NN
cord-018572-e2qq4ngq	351	23	-	-	HYPH
cord-018572-e2qq4ngq	351	24	mediated	mediate	VBN
cord-018572-e2qq4ngq	351	25	recruitment	recruitment	NN
cord-018572-e2qq4ngq	351	26	of	of	IN
cord-018572-e2qq4ngq	351	27	BRAG2	BRAG2	NNP
cord-018572-e2qq4ngq	351	28	,	,	,
cord-018572-e2qq4ngq	351	29	which	which	WDT
cord-018572-e2qq4ngq	351	30	in	in	IN
cord-018572-e2qq4ngq	351	31	turn	turn	NN
cord-018572-e2qq4ngq	351	32	activates	activate	VBZ
cord-018572-e2qq4ngq	351	33	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	351	34	and	and	CC
cord-018572-e2qq4ngq	351	35	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	352	1	(	(	-LRB-
cord-018572-e2qq4ngq	352	2	Scholz	Scholz	NNP
cord-018572-e2qq4ngq	352	3	et	et	FW
cord-018572-e2qq4ngq	352	4	al	al	NNP
cord-018572-e2qq4ngq	352	5	.	.	NNP
cord-018572-e2qq4ngq	352	6	2010	2010	CD
cord-018572-e2qq4ngq	352	7	)	)	-RRB-
cord-018572-e2qq4ngq	352	8	.	.	.
cord-018572-e2qq4ngq	353	1	The	the	DT
cord-018572-e2qq4ngq	353	2	GEFs	gefs	NN
cord-018572-e2qq4ngq	353	3	and	and	CC
cord-018572-e2qq4ngq	353	4	GAPs	gaps	NN
cord-018572-e2qq4ngq	353	5	for	for	IN
cord-018572-e2qq4ngq	353	6	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	353	7	and	and	CC
cord-018572-e2qq4ngq	353	8	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	353	9	at	at	IN
cord-018572-e2qq4ngq	353	10	the	the	DT
cord-018572-e2qq4ngq	353	11	cell	cell	NN
cord-018572-e2qq4ngq	353	12	periphery	periphery	NN
cord-018572-e2qq4ngq	353	13	have	have	VBP
cord-018572-e2qq4ngq	353	14	roles	role	NNS
cord-018572-e2qq4ngq	353	15	which	which	WDT
cord-018572-e2qq4ngq	353	16	are	be	VBP
cord-018572-e2qq4ngq	353	17	becoming	become	VBG
cord-018572-e2qq4ngq	353	18	more	more	RBR
cord-018572-e2qq4ngq	353	19	clearly	clearly	RB
cord-018572-e2qq4ngq	353	20	defined	define	VBN
cord-018572-e2qq4ngq	353	21	in	in	IN
cord-018572-e2qq4ngq	353	22	the	the	DT
cord-018572-e2qq4ngq	353	23	progression	progression	NN
cord-018572-e2qq4ngq	353	24	of	of	IN
cord-018572-e2qq4ngq	353	25	numerous	numerous	JJ
cord-018572-e2qq4ngq	353	26	cancers	cancer	NNS
cord-018572-e2qq4ngq	353	27	(	(	-LRB-
cord-018572-e2qq4ngq	353	28	D	D	NNP
cord-018572-e2qq4ngq	353	29	'	'	''
cord-018572-e2qq4ngq	353	30	Souza	Souza	NNP
cord-018572-e2qq4ngq	353	31	-	-	HYPH
cord-018572-e2qq4ngq	353	32	Schorey	Schorey	NNP
cord-018572-e2qq4ngq	353	33	and	and	CC
cord-018572-e2qq4ngq	353	34	Chavrier	Chavrier	NNP
cord-018572-e2qq4ngq	353	35	2006	2006	CD
cord-018572-e2qq4ngq	353	36	;	;	:
cord-018572-e2qq4ngq	354	1	Muller	Muller	NNP
cord-018572-e2qq4ngq	354	2	et	et	NNP
cord-018572-e2qq4ngq	354	3	al	al	NNP
cord-018572-e2qq4ngq	354	4	.	.	.
cord-018572-e2qq4ngq	354	5	2010	2010	CD
cord-018572-e2qq4ngq	355	1	;	;	:
cord-018572-e2qq4ngq	355	2	Peng	Peng	NNP
cord-018572-e2qq4ngq	355	3	et	et	NNP
cord-018572-e2qq4ngq	355	4	al	al	NNP
cord-018572-e2qq4ngq	355	5	.	.	.
cord-018572-e2qq4ngq	356	1	2013	2013	CD
cord-018572-e2qq4ngq	356	2	;	;	:
cord-018572-e2qq4ngq	356	3	Sabe	Sabe	NNP
cord-018572-e2qq4ngq	356	4	et	et	FW
cord-018572-e2qq4ngq	356	5	al	al	NNP
cord-018572-e2qq4ngq	356	6	.	.	.
cord-018572-e2qq4ngq	357	1	2006	2006	CD
cord-018572-e2qq4ngq	358	1	Sabe	Sabe	NNP
cord-018572-e2qq4ngq	358	2	et	et	NNP
cord-018572-e2qq4ngq	358	3	al	al	NNP
cord-018572-e2qq4ngq	358	4	.	.	NNP
cord-018572-e2qq4ngq	358	5	,	,	,
cord-018572-e2qq4ngq	359	1	2009	2009	CD
cord-018572-e2qq4ngq	359	2	Sangar	Sangar	NNP
cord-018572-e2qq4ngq	359	3	et	et	FW
cord-018572-e2qq4ngq	359	4	al	al	NNP
cord-018572-e2qq4ngq	359	5	.	.	.
cord-018572-e2qq4ngq	360	1	2014	2014	CD
cord-018572-e2qq4ngq	361	1	;	;	:
cord-018572-e2qq4ngq	361	2	Yoo	Yoo	NNP
cord-018572-e2qq4ngq	361	3	et	et	NNP
cord-018572-e2qq4ngq	361	4	al	al	NNP
cord-018572-e2qq4ngq	361	5	.	.	NNP
cord-018572-e2qq4ngq	361	6	2012	2012	CD
cord-018572-e2qq4ngq	361	7	)	)	-RRB-
cord-018572-e2qq4ngq	361	8	.	.	.
cord-018572-e2qq4ngq	362	1	Cytohesin	Cytohesin	NNP
cord-018572-e2qq4ngq	362	2	/	/	SYM
cord-018572-e2qq4ngq	362	3	Arno	Arno	NNP
cord-018572-e2qq4ngq	362	4	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	362	5	affect	affect	VBP
cord-018572-e2qq4ngq	362	6	signalling	signal	VBG
cord-018572-e2qq4ngq	362	7	through	through	IN
cord-018572-e2qq4ngq	362	8	epidermal	epidermal	JJ
cord-018572-e2qq4ngq	362	9	growth	growth	NN
cord-018572-e2qq4ngq	362	10	factor	factor	NN
cord-018572-e2qq4ngq	362	11	(	(	-LRB-
cord-018572-e2qq4ngq	362	12	EGF)/ErbB	EGF)/ErbB	NNP
cord-018572-e2qq4ngq	362	13	,	,	,
cord-018572-e2qq4ngq	362	14	promoting	promote	VBG
cord-018572-e2qq4ngq	362	15	conformational	conformational	JJ
cord-018572-e2qq4ngq	362	16	changes	change	NNS
cord-018572-e2qq4ngq	362	17	that	that	WDT
cord-018572-e2qq4ngq	362	18	increase	increase	VBP
cord-018572-e2qq4ngq	362	19	trans	trans	NN
cord-018572-e2qq4ngq	362	20	-	-	NN
cord-018572-e2qq4ngq	362	21	phosphorylation	phosphorylation	NN
cord-018572-e2qq4ngq	362	22	of	of	IN
cord-018572-e2qq4ngq	362	23	EGFRs	egfr	NNS
cord-018572-e2qq4ngq	362	24	upon	upon	IN
cord-018572-e2qq4ngq	362	25	ligand	ligand	NN
cord-018572-e2qq4ngq	362	26	-	-	HYPH
cord-018572-e2qq4ngq	362	27	induced	induce	VBN
cord-018572-e2qq4ngq	362	28	dimerization	dimerization	NN
cord-018572-e2qq4ngq	362	29	(	(	-LRB-
cord-018572-e2qq4ngq	362	30	Bill	Bill	NNP
cord-018572-e2qq4ngq	362	31	et	et	NNP
cord-018572-e2qq4ngq	362	32	al	al	NNP
cord-018572-e2qq4ngq	362	33	.	.	NNP
cord-018572-e2qq4ngq	362	34	2010	2010	CD
cord-018572-e2qq4ngq	362	35	)	)	-RRB-
cord-018572-e2qq4ngq	362	36	.	.	.
cord-018572-e2qq4ngq	363	1	Importantly	importantly	RB
cord-018572-e2qq4ngq	363	2	,	,	,
cord-018572-e2qq4ngq	363	3	these	these	DT
cord-018572-e2qq4ngq	363	4	GEFs	gef	NNS
cord-018572-e2qq4ngq	363	5	are	be	VBP
cord-018572-e2qq4ngq	363	6	specifically	specifically	RB
cord-018572-e2qq4ngq	363	7	inhibited	inhibit	VBN
cord-018572-e2qq4ngq	363	8	by	by	IN
cord-018572-e2qq4ngq	363	9	SecinH3	SecinH3	NNP
cord-018572-e2qq4ngq	363	10	,	,	,
cord-018572-e2qq4ngq	363	11	which	which	WDT
cord-018572-e2qq4ngq	363	12	holds	hold	VBZ
cord-018572-e2qq4ngq	363	13	promise	promise	NN
cord-018572-e2qq4ngq	363	14	as	as	IN
cord-018572-e2qq4ngq	363	15	anti	anti	JJ
cord-018572-e2qq4ngq	363	16	-	-	JJ
cord-018572-e2qq4ngq	363	17	cancer	cancer	JJ
cord-018572-e2qq4ngq	363	18	drug	drug	NN
cord-018572-e2qq4ngq	363	19	,	,	,
cord-018572-e2qq4ngq	363	20	since	since	IN
cord-018572-e2qq4ngq	363	21	treatment	treatment	NN
cord-018572-e2qq4ngq	363	22	of	of	IN
cord-018572-e2qq4ngq	363	23	an	an	DT
cord-018572-e2qq4ngq	363	24	EGF	EGF	NNP
cord-018572-e2qq4ngq	363	25	receptor	receptor	NN
cord-018572-e2qq4ngq	363	26	-	-	HYPH
cord-018572-e2qq4ngq	363	27	dependent	dependent	JJ
cord-018572-e2qq4ngq	363	28	lung	lung	NN
cord-018572-e2qq4ngq	363	29	cancer	cancer	NN
cord-018572-e2qq4ngq	363	30	cell	cell	NN
cord-018572-e2qq4ngq	363	31	line	line	NN
cord-018572-e2qq4ngq	363	32	with	with	IN
cord-018572-e2qq4ngq	363	33	SecinH3	secinh3	NN
cord-018572-e2qq4ngq	363	34	resulted	result	VBN
cord-018572-e2qq4ngq	363	35	in	in	IN
cord-018572-e2qq4ngq	363	36	reduced	reduce	VBN
cord-018572-e2qq4ngq	363	37	proliferation	proliferation	NN
cord-018572-e2qq4ngq	363	38	(	(	-LRB-
cord-018572-e2qq4ngq	363	39	Bill	Bill	NNP
cord-018572-e2qq4ngq	363	40	et	et	NNP
cord-018572-e2qq4ngq	363	41	al	al	NNP
cord-018572-e2qq4ngq	363	42	.	.	NNP
cord-018572-e2qq4ngq	363	43	2010	2010	CD
cord-018572-e2qq4ngq	363	44	)	)	-RRB-
cord-018572-e2qq4ngq	363	45	.	.	.
cord-018572-e2qq4ngq	364	1	Arf	Arf	NNP
cord-018572-e2qq4ngq	364	2	proteins	protein	NNS
cord-018572-e2qq4ngq	364	3	and	and	CC
cord-018572-e2qq4ngq	364	4	their	-PRON-	PRP$
cord-018572-e2qq4ngq	364	5	regulators	regulator	NNS
cord-018572-e2qq4ngq	364	6	are	be	VBP
cord-018572-e2qq4ngq	364	7	hijacked	hijack	VBN
cord-018572-e2qq4ngq	364	8	by	by	IN
cord-018572-e2qq4ngq	364	9	numerous	numerous	JJ
cord-018572-e2qq4ngq	364	10	bacterial	bacterial	JJ
cord-018572-e2qq4ngq	364	11	and	and	CC
cord-018572-e2qq4ngq	364	12	viral	viral	JJ
cord-018572-e2qq4ngq	364	13	pathogens	pathogen	NNS
cord-018572-e2qq4ngq	364	14	(	(	-LRB-
cord-018572-e2qq4ngq	364	15	Dautry	Dautry	NNP
cord-018572-e2qq4ngq	364	16	-	-	HYPH
cord-018572-e2qq4ngq	364	17	Varsat	Varsat	NNP
cord-018572-e2qq4ngq	364	18	et	et	FW
cord-018572-e2qq4ngq	364	19	al	al	NNP
cord-018572-e2qq4ngq	364	20	.	.	NNP
cord-018572-e2qq4ngq	364	21	2005	2005	CD
cord-018572-e2qq4ngq	364	22	;	;	:
cord-018572-e2qq4ngq	364	23	Goody	Goody	NNP
cord-018572-e2qq4ngq	364	24	and	and	CC
cord-018572-e2qq4ngq	364	25	Itzen	Itzen	NNP
cord-018572-e2qq4ngq	364	26	2013	2013	CD
cord-018572-e2qq4ngq	364	27	;	;	:
cord-018572-e2qq4ngq	364	28	Hsu	Hsu	NNP
cord-018572-e2qq4ngq	364	29	et	et	NNP
cord-018572-e2qq4ngq	364	30	al	al	NNP
cord-018572-e2qq4ngq	364	31	.	.	NNP
cord-018572-e2qq4ngq	364	32	2010	2010	CD
cord-018572-e2qq4ngq	364	33	;	;	:
cord-018572-e2qq4ngq	364	34	Humphreys	Humphreys	NNP
cord-018572-e2qq4ngq	364	35	et	et	NNP
cord-018572-e2qq4ngq	364	36	al	al	NNP
cord-018572-e2qq4ngq	364	37	.	.	NNP
cord-018572-e2qq4ngq	364	38	2013	2013	CD
cord-018572-e2qq4ngq	364	39	;	;	:
cord-018572-e2qq4ngq	364	40	Matto	Matto	NNP
cord-018572-e2qq4ngq	364	41	et	et	NNP
cord-018572-e2qq4ngq	364	42	al	al	NNP
cord-018572-e2qq4ngq	364	43	.	.	NNP
cord-018572-e2qq4ngq	364	44	2011	2011	CD
cord-018572-e2qq4ngq	364	45	)	)	-RRB-
cord-018572-e2qq4ngq	364	46	.	.	.
cord-018572-e2qq4ngq	365	1	The	the	DT
cord-018572-e2qq4ngq	365	2	Arf	Arf	NNP
cord-018572-e2qq4ngq	365	3	GEF	GEF	NNP
cord-018572-e2qq4ngq	365	4	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	365	5	is	be	VBZ
cord-018572-e2qq4ngq	365	6	required	require	VBN
cord-018572-e2qq4ngq	365	7	for	for	IN
cord-018572-e2qq4ngq	365	8	the	the	DT
cord-018572-e2qq4ngq	365	9	replication	replication	NN
cord-018572-e2qq4ngq	365	10	of	of	IN
cord-018572-e2qq4ngq	365	11	numerous	numerous	JJ
cord-018572-e2qq4ngq	365	12	viruses	virus	NNS
cord-018572-e2qq4ngq	365	13	,	,	,
cord-018572-e2qq4ngq	365	14	including	include	VBG
cord-018572-e2qq4ngq	365	15	enteroviruses	enterovirus	NNS
cord-018572-e2qq4ngq	365	16	,	,	,
cord-018572-e2qq4ngq	365	17	hepatitis	hepatitis	NN
cord-018572-e2qq4ngq	365	18	C	C	NNP
cord-018572-e2qq4ngq	365	19	virus	virus	NN
cord-018572-e2qq4ngq	365	20	,	,	,
cord-018572-e2qq4ngq	365	21	and	and	CC
cord-018572-e2qq4ngq	365	22	coronaviruses	coronaviruse	NNS
cord-018572-e2qq4ngq	365	23	(	(	-LRB-
cord-018572-e2qq4ngq	365	24	Belov	Belov	NNP
cord-018572-e2qq4ngq	365	25	et	et	FW
cord-018572-e2qq4ngq	365	26	al	al	NNP
cord-018572-e2qq4ngq	365	27	.	.	.
cord-018572-e2qq4ngq	366	1	2008	2008	CD
cord-018572-e2qq4ngq	366	2	;	;	:
cord-018572-e2qq4ngq	366	3	Goueslain	Goueslain	NNP
cord-018572-e2qq4ngq	366	4	et	et	NNP
cord-018572-e2qq4ngq	366	5	al	al	NNP
cord-018572-e2qq4ngq	366	6	.	.	.
cord-018572-e2qq4ngq	367	1	2010	2010	CD
cord-018572-e2qq4ngq	367	2	;	;	:
cord-018572-e2qq4ngq	367	3	Lanke	Lanke	NNP
cord-018572-e2qq4ngq	367	4	et	et	FW
cord-018572-e2qq4ngq	367	5	al	al	NNP
cord-018572-e2qq4ngq	367	6	.	.	NNP
cord-018572-e2qq4ngq	367	7	2009	2009	CD
cord-018572-e2qq4ngq	367	8	;	;	:
cord-018572-e2qq4ngq	367	9	Winchester	Winchester	NNP
cord-018572-e2qq4ngq	367	10	et	et	NNP
cord-018572-e2qq4ngq	367	11	al	al	NNP
cord-018572-e2qq4ngq	367	12	.	.	NNP
cord-018572-e2qq4ngq	367	13	2008	2008	CD
cord-018572-e2qq4ngq	367	14	)	)	-RRB-
cord-018572-e2qq4ngq	367	15	.	.	.
cord-018572-e2qq4ngq	368	1	These	these	DT
cord-018572-e2qq4ngq	368	2	viruses	virus	NNS
cord-018572-e2qq4ngq	368	3	remodel	remodel	VBP
cord-018572-e2qq4ngq	368	4	ER	er	NN
cord-018572-e2qq4ngq	368	5	and	and	CC
cord-018572-e2qq4ngq	368	6	early	early	JJ
cord-018572-e2qq4ngq	368	7	secretory	secretory	JJ
cord-018572-e2qq4ngq	368	8	pathway	pathway	NN
cord-018572-e2qq4ngq	368	9	membranes	membrane	NNS
cord-018572-e2qq4ngq	368	10	to	to	TO
cord-018572-e2qq4ngq	368	11	form	form	VB
cord-018572-e2qq4ngq	368	12	replication	replication	NN
cord-018572-e2qq4ngq	368	13	complexes	complex	NNS
cord-018572-e2qq4ngq	368	14	,	,	,
cord-018572-e2qq4ngq	368	15	for	for	IN
cord-018572-e2qq4ngq	368	16	which	which	WDT
cord-018572-e2qq4ngq	368	17	they	-PRON-	PRP
cord-018572-e2qq4ngq	368	18	subvert	subvert	VBP
cord-018572-e2qq4ngq	368	19	the	the	DT
cord-018572-e2qq4ngq	368	20	function	function	NN
cord-018572-e2qq4ngq	368	21	of	of	IN
cord-018572-e2qq4ngq	368	22	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	368	23	.	.	.
cord-018572-e2qq4ngq	369	1	Interestingly	interestingly	RB
cord-018572-e2qq4ngq	369	2	,	,	,
cord-018572-e2qq4ngq	369	3	a	a	DT
cord-018572-e2qq4ngq	369	4	major	major	JJ
cord-018572-e2qq4ngq	369	5	requirement	requirement	NN
cord-018572-e2qq4ngq	369	6	for	for	IN
cord-018572-e2qq4ngq	369	7	replication	replication	NN
cord-018572-e2qq4ngq	369	8	of	of	IN
cord-018572-e2qq4ngq	369	9	several	several	JJ
cord-018572-e2qq4ngq	369	10	of	of	IN
cord-018572-e2qq4ngq	369	11	these	these	DT
cord-018572-e2qq4ngq	369	12	viruses	virus	NNS
cord-018572-e2qq4ngq	369	13	is	be	VBZ
cord-018572-e2qq4ngq	369	14	gaining	gain	VBG
cord-018572-e2qq4ngq	369	15	control	control	NN
cord-018572-e2qq4ngq	369	16	of	of	IN
cord-018572-e2qq4ngq	369	17	host	host	NN
cord-018572-e2qq4ngq	369	18	lipid	lipid	NN
cord-018572-e2qq4ngq	369	19	trafficking	trafficking	NN
cord-018572-e2qq4ngq	369	20	and	and	CC
cord-018572-e2qq4ngq	369	21	metabolism	metabolism	NN
cord-018572-e2qq4ngq	369	22	pathways	pathway	NNS
cord-018572-e2qq4ngq	370	1	(	(	-LRB-
cord-018572-e2qq4ngq	370	2	Alvisi	Alvisi	NNP
cord-018572-e2qq4ngq	370	3	et	et	NNP
cord-018572-e2qq4ngq	370	4	al	al	NNP
cord-018572-e2qq4ngq	370	5	.	.	.
cord-018572-e2qq4ngq	370	6	2011	2011	CD
cord-018572-e2qq4ngq	371	1	;	;	:
cord-018572-e2qq4ngq	371	2	Hsu	Hsu	NNP
cord-018572-e2qq4ngq	371	3	et	et	NNP
cord-018572-e2qq4ngq	371	4	al	al	NNP
cord-018572-e2qq4ngq	371	5	.	.	.
cord-018572-e2qq4ngq	372	1	2010	2010	CD
cord-018572-e2qq4ngq	372	2	;	;	:
cord-018572-e2qq4ngq	372	3	Ilnytska	Ilnytska	NNP
cord-018572-e2qq4ngq	372	4	et	et	NNP
cord-018572-e2qq4ngq	372	5	al	al	NNP
cord-018572-e2qq4ngq	372	6	.	.	NNP
cord-018572-e2qq4ngq	372	7	2013	2013	CD
cord-018572-e2qq4ngq	372	8	)	)	-RRB-
cord-018572-e2qq4ngq	372	9	.	.	.
cord-018572-e2qq4ngq	373	1	The	the	DT
cord-018572-e2qq4ngq	373	2	activity	activity	NN
cord-018572-e2qq4ngq	373	3	of	of	IN
cord-018572-e2qq4ngq	373	4	Arf	Arf	NNP
cord-018572-e2qq4ngq	373	5	proteins	protein	NNS
cord-018572-e2qq4ngq	373	6	is	be	VBZ
cord-018572-e2qq4ngq	373	7	regulated	regulate	VBN
cord-018572-e2qq4ngq	373	8	in	in	IN
cord-018572-e2qq4ngq	373	9	a	a	DT
cord-018572-e2qq4ngq	373	10	spatiotemporal	spatiotemporal	JJ
cord-018572-e2qq4ngq	373	11	manner	manner	NN
cord-018572-e2qq4ngq	373	12	by	by	IN
cord-018572-e2qq4ngq	373	13	their	-PRON-	PRP$
cord-018572-e2qq4ngq	373	14	GEFs	gef	NNS
cord-018572-e2qq4ngq	373	15	and	and	CC
cord-018572-e2qq4ngq	373	16	GAPs	GAPs	NNP
cord-018572-e2qq4ngq	373	17	,	,	,
cord-018572-e2qq4ngq	373	18	highlighting	highlight	VBG
cord-018572-e2qq4ngq	373	19	the	the	DT
cord-018572-e2qq4ngq	373	20	importance	importance	NN
cord-018572-e2qq4ngq	373	21	of	of	IN
cord-018572-e2qq4ngq	373	22	precise	precise	JJ
cord-018572-e2qq4ngq	373	23	localization	localization	NN
cord-018572-e2qq4ngq	373	24	of	of	IN
cord-018572-e2qq4ngq	373	25	these	these	DT
cord-018572-e2qq4ngq	373	26	regulators	regulator	NNS
cord-018572-e2qq4ngq	373	27	.	.	.
cord-018572-e2qq4ngq	374	1	The	the	DT
cord-018572-e2qq4ngq	374	2	mechanisms	mechanism	NNS
cord-018572-e2qq4ngq	374	3	of	of	IN
cord-018572-e2qq4ngq	374	4	this	this	DT
cord-018572-e2qq4ngq	374	5	spatiotemporal	spatiotemporal	JJ
cord-018572-e2qq4ngq	374	6	control	control	NN
cord-018572-e2qq4ngq	374	7	are	be	VBP
cord-018572-e2qq4ngq	374	8	now	now	RB
cord-018572-e2qq4ngq	374	9	beginning	begin	VBG
cord-018572-e2qq4ngq	374	10	to	to	TO
cord-018572-e2qq4ngq	374	11	emerge	emerge	VB
cord-018572-e2qq4ngq	374	12	.	.	.
cord-018572-e2qq4ngq	375	1	Coincidence	coincidence	NN
cord-018572-e2qq4ngq	375	2	detection	detection	NN
cord-018572-e2qq4ngq	375	3	mechanisms	mechanism	NNS
cord-018572-e2qq4ngq	375	4	involving	involve	VBG
cord-018572-e2qq4ngq	375	5	binding	bind	VBG
cord-018572-e2qq4ngq	375	6	to	to	IN
cord-018572-e2qq4ngq	375	7	specific	specific	JJ
cord-018572-e2qq4ngq	375	8	lipids	lipid	NNS
cord-018572-e2qq4ngq	375	9	and	and	CC
cord-018572-e2qq4ngq	375	10	protein	protein	NN
cord-018572-e2qq4ngq	375	11	partners	partner	NNS
cord-018572-e2qq4ngq	375	12	play	play	VBP
cord-018572-e2qq4ngq	375	13	an	an	DT
cord-018572-e2qq4ngq	375	14	important	important	JJ
cord-018572-e2qq4ngq	375	15	role	role	NN
cord-018572-e2qq4ngq	375	16	,	,	,
cord-018572-e2qq4ngq	375	17	and	and	CC
cord-018572-e2qq4ngq	375	18	for	for	IN
cord-018572-e2qq4ngq	375	19	the	the	DT
cord-018572-e2qq4ngq	375	20	cytohesins	cytohesin	NNS
cord-018572-e2qq4ngq	375	21	,	,	,
cord-018572-e2qq4ngq	375	22	a	a	DT
cord-018572-e2qq4ngq	375	23	fairly	fairly	RB
cord-018572-e2qq4ngq	375	24	complete	complete	JJ
cord-018572-e2qq4ngq	375	25	description	description	NN
cord-018572-e2qq4ngq	375	26	of	of	IN
cord-018572-e2qq4ngq	375	27	how	how	WRB
cord-018572-e2qq4ngq	375	28	relief	relief	NN
cord-018572-e2qq4ngq	375	29	of	of	IN
cord-018572-e2qq4ngq	375	30	autoinhibition	autoinhibition	NN
cord-018572-e2qq4ngq	375	31	is	be	VBZ
cord-018572-e2qq4ngq	375	32	coupled	couple	VBN
cord-018572-e2qq4ngq	375	33	to	to	IN
cord-018572-e2qq4ngq	375	34	precise	precise	JJ
cord-018572-e2qq4ngq	375	35	spatial	spatial	JJ
cord-018572-e2qq4ngq	375	36	cues	cue	NNS
cord-018572-e2qq4ngq	375	37	has	have	VBZ
cord-018572-e2qq4ngq	375	38	been	be	VBN
cord-018572-e2qq4ngq	375	39	obtained	obtain	VBN
cord-018572-e2qq4ngq	375	40	.	.	.
cord-018572-e2qq4ngq	376	1	Arf	Arf	NNP
cord-018572-e2qq4ngq	376	2	activation	activation	NN
cord-018572-e2qq4ngq	376	3	cascades	cascade	NNS
cord-018572-e2qq4ngq	376	4	have	have	VBP
cord-018572-e2qq4ngq	376	5	been	be	VBN
cord-018572-e2qq4ngq	376	6	demonstrated	demonstrate	VBN
cord-018572-e2qq4ngq	376	7	for	for	IN
cord-018572-e2qq4ngq	376	8	the	the	DT
cord-018572-e2qq4ngq	376	9	cytohesins	cytohesin	NNS
cord-018572-e2qq4ngq	376	10	,	,	,
cord-018572-e2qq4ngq	376	11	but	but	CC
cord-018572-e2qq4ngq	376	12	may	may	MD
cord-018572-e2qq4ngq	376	13	play	play	VB
cord-018572-e2qq4ngq	376	14	an	an	DT
cord-018572-e2qq4ngq	376	15	important	important	JJ
cord-018572-e2qq4ngq	376	16	role	role	NN
cord-018572-e2qq4ngq	376	17	in	in	IN
cord-018572-e2qq4ngq	376	18	the	the	DT
cord-018572-e2qq4ngq	376	19	activation	activation	NN
cord-018572-e2qq4ngq	376	20	of	of	IN
cord-018572-e2qq4ngq	376	21	other	other	JJ
cord-018572-e2qq4ngq	376	22	families	family	NNS
cord-018572-e2qq4ngq	376	23	of	of	IN
cord-018572-e2qq4ngq	376	24	GEFs	gef	NNS
cord-018572-e2qq4ngq	376	25	as	as	RB
cord-018572-e2qq4ngq	376	26	well	well	RB
cord-018572-e2qq4ngq	376	27	.	.	.
cord-018572-e2qq4ngq	377	1	Such	such	JJ
cord-018572-e2qq4ngq	377	2	cascades	cascade	NNS
cord-018572-e2qq4ngq	377	3	,	,	,
cord-018572-e2qq4ngq	377	4	similarly	similarly	RB
cord-018572-e2qq4ngq	377	5	to	to	IN
cord-018572-e2qq4ngq	377	6	those	those	DT
cord-018572-e2qq4ngq	377	7	demonstrated	demonstrate	VBN
cord-018572-e2qq4ngq	377	8	for	for	IN
cord-018572-e2qq4ngq	377	9	Rab	Rab	NNP
cord-018572-e2qq4ngq	377	10	G	G	NNP
cord-018572-e2qq4ngq	377	11	proteins	protein	NNS
cord-018572-e2qq4ngq	377	12	,	,	,
cord-018572-e2qq4ngq	377	13	could	could	MD
cord-018572-e2qq4ngq	377	14	be	be	VB
cord-018572-e2qq4ngq	377	15	involved	involve	VBN
cord-018572-e2qq4ngq	377	16	in	in	IN
cord-018572-e2qq4ngq	377	17	transforming	transform	VBG
cord-018572-e2qq4ngq	377	18	one	one	CD
cord-018572-e2qq4ngq	377	19	membrane	membrane	NN
cord-018572-e2qq4ngq	377	20	domain	domain	NN
cord-018572-e2qq4ngq	377	21	into	into	IN
cord-018572-e2qq4ngq	377	22	another	another	DT
cord-018572-e2qq4ngq	377	23	during	during	IN
cord-018572-e2qq4ngq	377	24	highly	highly	RB
cord-018572-e2qq4ngq	377	25	dynamic	dynamic	JJ
cord-018572-e2qq4ngq	377	26	membrane	membrane	NN
cord-018572-e2qq4ngq	377	27	trafficking	traffic	VBG
cord-018572-e2qq4ngq	377	28	maturation	maturation	NN
cord-018572-e2qq4ngq	377	29	events	event	NNS
cord-018572-e2qq4ngq	377	30	.	.	.
cord-018572-e2qq4ngq	378	1	These	these	DT
cord-018572-e2qq4ngq	378	2	transformations	transformation	NNS
cord-018572-e2qq4ngq	378	3	involve	involve	VBP
cord-018572-e2qq4ngq	378	4	coordinate	coordinate	JJ
cord-018572-e2qq4ngq	378	5	changes	change	NNS
cord-018572-e2qq4ngq	378	6	in	in	IN
cord-018572-e2qq4ngq	378	7	both	both	CC
cord-018572-e2qq4ngq	378	8	the	the	DT
cord-018572-e2qq4ngq	378	9	lipid	lipid	NN
cord-018572-e2qq4ngq	378	10	and	and	CC
cord-018572-e2qq4ngq	378	11	protein	protein	NN
cord-018572-e2qq4ngq	378	12	composition	composition	NN
cord-018572-e2qq4ngq	378	13	of	of	IN
cord-018572-e2qq4ngq	378	14	each	each	DT
cord-018572-e2qq4ngq	378	15	membrane	membrane	NN
cord-018572-e2qq4ngq	378	16	domain	domain	NN
cord-018572-e2qq4ngq	378	17	,	,	,
cord-018572-e2qq4ngq	378	18	a	a	DT
cord-018572-e2qq4ngq	378	19	specific	specific	JJ
cord-018572-e2qq4ngq	378	20	function	function	NN
cord-018572-e2qq4ngq	378	21	of	of	IN
cord-018572-e2qq4ngq	378	22	the	the	DT
cord-018572-e2qq4ngq	378	23	Arf	Arf	NNP
cord-018572-e2qq4ngq	378	24	family	family	NN
cord-018572-e2qq4ngq	378	25	members	member	NNS
cord-018572-e2qq4ngq	378	26	,	,	,
cord-018572-e2qq4ngq	378	27	which	which	WDT
cord-018572-e2qq4ngq	378	28	recruit	recruit	VBP
cord-018572-e2qq4ngq	378	29	both	both	DT
cord-018572-e2qq4ngq	378	30	lipid	lipid	NN
cord-018572-e2qq4ngq	378	31	-	-	HYPH
cord-018572-e2qq4ngq	378	32	modifying	modify	VBG
cord-018572-e2qq4ngq	378	33	enzymes	enzyme	NNS
cord-018572-e2qq4ngq	378	34	and	and	CC
cord-018572-e2qq4ngq	378	35	protein	protein	NN
cord-018572-e2qq4ngq	378	36	effectors	effector	NNS
cord-018572-e2qq4ngq	378	37	such	such	JJ
cord-018572-e2qq4ngq	378	38	as	as	IN
cord-018572-e2qq4ngq	378	39	coats	coat	NNS
cord-018572-e2qq4ngq	378	40	and	and	CC
cord-018572-e2qq4ngq	378	41	tethers	tether	NNS
cord-018572-e2qq4ngq	378	42	.	.	.
cord-018572-e2qq4ngq	379	1	The	the	DT
cord-018572-e2qq4ngq	379	2	signature	signature	NN
cord-018572-e2qq4ngq	379	3	feature	feature	NN
cord-018572-e2qq4ngq	379	4	of	of	IN
cord-018572-e2qq4ngq	379	5	Arf	Arf	NNP
cord-018572-e2qq4ngq	379	6	family	family	NN
cord-018572-e2qq4ngq	379	7	proteins	protein	NNS
cord-018572-e2qq4ngq	379	8	,	,	,
cord-018572-e2qq4ngq	379	9	their	-PRON-	PRP$
cord-018572-e2qq4ngq	379	10	N	n	CD
cord-018572-e2qq4ngq	379	11	-	-	HYPH
cord-018572-e2qq4ngq	379	12	terminal	terminal	NN
cord-018572-e2qq4ngq	379	13	membrane	membrane	NN
cord-018572-e2qq4ngq	379	14	-	-	HYPH
cord-018572-e2qq4ngq	379	15	binding	bind	VBG
cord-018572-e2qq4ngq	379	16	amphipathic	amphipathic	NNP
cord-018572-e2qq4ngq	379	17	helix	helix	NNP
cord-018572-e2qq4ngq	379	18	,	,	,
cord-018572-e2qq4ngq	379	19	ensures	ensure	VBZ
cord-018572-e2qq4ngq	379	20	that	that	IN
cord-018572-e2qq4ngq	379	21	they	-PRON-	PRP
cord-018572-e2qq4ngq	379	22	are	be	VBP
cord-018572-e2qq4ngq	379	23	closely	closely	RB
cord-018572-e2qq4ngq	379	24	associated	associate	VBN
cord-018572-e2qq4ngq	379	25	with	with	IN
cord-018572-e2qq4ngq	379	26	the	the	DT
cord-018572-e2qq4ngq	379	27	lipid	lipid	NN
cord-018572-e2qq4ngq	379	28	bilayer	bilayer	NN
cord-018572-e2qq4ngq	379	29	in	in	IN
cord-018572-e2qq4ngq	379	30	their	-PRON-	PRP$
cord-018572-e2qq4ngq	379	31	GTP	gtp	NN
cord-018572-e2qq4ngq	379	32	-	-	HYPH
cord-018572-e2qq4ngq	379	33	bound	bind	VBN
cord-018572-e2qq4ngq	379	34	form	form	NN
cord-018572-e2qq4ngq	379	35	.	.	.
cord-018572-e2qq4ngq	380	1	Future	future	JJ
cord-018572-e2qq4ngq	380	2	studies	study	NNS
cord-018572-e2qq4ngq	380	3	on	on	IN
cord-018572-e2qq4ngq	380	4	how	how	WRB
cord-018572-e2qq4ngq	380	5	Arf	Arf	NNP
cord-018572-e2qq4ngq	380	6	family	family	NN
cord-018572-e2qq4ngq	380	7	proteins	protein	NNS
cord-018572-e2qq4ngq	380	8	function	function	VBP
cord-018572-e2qq4ngq	380	9	will	will	MD
cord-018572-e2qq4ngq	380	10	therefore	therefore	RB
cord-018572-e2qq4ngq	380	11	continue	continue	VB
cord-018572-e2qq4ngq	380	12	to	to	TO
cord-018572-e2qq4ngq	380	13	require	require	VB
cord-018572-e2qq4ngq	380	14	in	in	IN
cord-018572-e2qq4ngq	380	15	vitro	vitro	FW
cord-018572-e2qq4ngq	380	16	reconstitution	reconstitution	NN
cord-018572-e2qq4ngq	380	17	on	on	IN
cord-018572-e2qq4ngq	380	18	model	model	NN
cord-018572-e2qq4ngq	380	19	membranes	membrane	NNS
cord-018572-e2qq4ngq	380	20	.	.	.
cord-018572-e2qq4ngq	381	1	Among	among	IN
cord-018572-e2qq4ngq	381	2	the	the	DT
cord-018572-e2qq4ngq	381	3	small	small	JJ
cord-018572-e2qq4ngq	381	4	G	g	NN
cord-018572-e2qq4ngq	381	5	proteins	protein	NNS
cord-018572-e2qq4ngq	381	6	,	,	,
cord-018572-e2qq4ngq	381	7	the	the	DT
cord-018572-e2qq4ngq	381	8	Arf	Arf	NNP
cord-018572-e2qq4ngq	381	9	family	family	NN
cord-018572-e2qq4ngq	381	10	is	be	VBZ
cord-018572-e2qq4ngq	381	11	perhaps	perhaps	RB
cord-018572-e2qq4ngq	381	12	the	the	DT
cord-018572-e2qq4ngq	381	13	most	most	RBS
cord-018572-e2qq4ngq	381	14	enigmatic	enigmatic	JJ
cord-018572-e2qq4ngq	381	15	.	.	.
cord-018572-e2qq4ngq	382	1	Why	why	WRB
cord-018572-e2qq4ngq	382	2	so	so	RB
cord-018572-e2qq4ngq	382	3	few	few	JJ
cord-018572-e2qq4ngq	382	4	?	?	.
cord-018572-e2qq4ngq	383	1	What	what	WP
cord-018572-e2qq4ngq	383	2	is	be	VBZ
cord-018572-e2qq4ngq	383	3	the	the	DT
cord-018572-e2qq4ngq	383	4	unifying	unifying	JJ
cord-018572-e2qq4ngq	383	5	principle	principle	NN
cord-018572-e2qq4ngq	383	6	in	in	IN
cord-018572-e2qq4ngq	383	7	the	the	DT
cord-018572-e2qq4ngq	383	8	broad	broad	JJ
cord-018572-e2qq4ngq	383	9	range	range	NN
cord-018572-e2qq4ngq	383	10	of	of	IN
cord-018572-e2qq4ngq	383	11	functions	function	NNS
cord-018572-e2qq4ngq	383	12	defined	define	VBN
cord-018572-e2qq4ngq	383	13	for	for	IN
cord-018572-e2qq4ngq	383	14	each	each	DT
cord-018572-e2qq4ngq	383	15	one	one	CD
cord-018572-e2qq4ngq	383	16	?	?	.
cord-018572-e2qq4ngq	384	1	The	the	DT
cord-018572-e2qq4ngq	384	2	small	small	JJ
cord-018572-e2qq4ngq	384	3	number	number	NN
cord-018572-e2qq4ngq	384	4	of	of	IN
cord-018572-e2qq4ngq	384	5	Arf	Arf	NNP
cord-018572-e2qq4ngq	384	6	proteins	protein	NNS
cord-018572-e2qq4ngq	384	7	in	in	IN
cord-018572-e2qq4ngq	384	8	a	a	DT
cord-018572-e2qq4ngq	384	9	given	give	VBN
cord-018572-e2qq4ngq	384	10	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	384	11	cell	cell	NN
cord-018572-e2qq4ngq	384	12	is	be	VBZ
cord-018572-e2qq4ngq	384	13	an	an	DT
cord-018572-e2qq4ngq	384	14	ancient	ancient	JJ
cord-018572-e2qq4ngq	384	15	property	property	NN
cord-018572-e2qq4ngq	384	16	of	of	IN
cord-018572-e2qq4ngq	384	17	the	the	DT
cord-018572-e2qq4ngq	384	18	Arf	Arf	NNP
cord-018572-e2qq4ngq	384	19	proteins	protein	NNS
cord-018572-e2qq4ngq	384	20	,	,	,
cord-018572-e2qq4ngq	384	21	since	since	IN
cord-018572-e2qq4ngq	384	22	phylogenetic	phylogenetic	JJ
cord-018572-e2qq4ngq	384	23	analyses	analysis	NNS
cord-018572-e2qq4ngq	384	24	indicate	indicate	VBP
cord-018572-e2qq4ngq	384	25	that	that	IN
cord-018572-e2qq4ngq	384	26	the	the	DT
cord-018572-e2qq4ngq	384	27	last	last	JJ
cord-018572-e2qq4ngq	384	28	common	common	JJ
cord-018572-e2qq4ngq	384	29	ancestor	ancestor	NN
cord-018572-e2qq4ngq	384	30	of	of	IN
cord-018572-e2qq4ngq	384	31	the	the	DT
cord-018572-e2qq4ngq	384	32	eukaryotes	eukaryote	NNS
cord-018572-e2qq4ngq	384	33	had	have	VBD
cord-018572-e2qq4ngq	384	34	only	only	RB
cord-018572-e2qq4ngq	384	35	one	one	CD
cord-018572-e2qq4ngq	384	36	Arf	Arf	NNP
cord-018572-e2qq4ngq	384	37	protein	protein	NN
cord-018572-e2qq4ngq	384	38	,	,	,
cord-018572-e2qq4ngq	384	39	despite	despite	IN
cord-018572-e2qq4ngq	384	40	a	a	DT
cord-018572-e2qq4ngq	384	41	significant	significant	JJ
cord-018572-e2qq4ngq	384	42	level	level	NN
cord-018572-e2qq4ngq	384	43	of	of	IN
cord-018572-e2qq4ngq	384	44	complexity	complexity	NN
cord-018572-e2qq4ngq	384	45	,	,	,
cord-018572-e2qq4ngq	384	46	and	and	CC
cord-018572-e2qq4ngq	384	47	numerous	numerous	JJ
cord-018572-e2qq4ngq	384	48	distinct	distinct	JJ
cord-018572-e2qq4ngq	384	49	Arf	Arf	NNP
cord-018572-e2qq4ngq	384	50	regulators	regulator	NNS
cord-018572-e2qq4ngq	384	51	and	and	CC
cord-018572-e2qq4ngq	384	52	effectors	effector	NNS
cord-018572-e2qq4ngq	384	53	(	(	-LRB-
cord-018572-e2qq4ngq	384	54	COPI	COPI	NNP
cord-018572-e2qq4ngq	384	55	,	,	,
cord-018572-e2qq4ngq	384	56	trans	trans	NNP
cord-018572-e2qq4ngq	384	57	-	-	JJ
cord-018572-e2qq4ngq	384	58	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	384	59	clathrin	clathrin	NN
cord-018572-e2qq4ngq	384	60	-	-	HYPH
cord-018572-e2qq4ngq	384	61	adaptor	adaptor	NN
cord-018572-e2qq4ngq	384	62	proteins	protein	NNS
cord-018572-e2qq4ngq	384	63	,	,	,
cord-018572-e2qq4ngq	384	64	coiled	coiled	JJ
cord-018572-e2qq4ngq	384	65	-	-	HYPH
cord-018572-e2qq4ngq	384	66	coil	coil	NN
cord-018572-e2qq4ngq	384	67	tether	tether	NN
cord-018572-e2qq4ngq	384	68	,	,	,
cord-018572-e2qq4ngq	384	69	and	and	CC
cord-018572-e2qq4ngq	384	70	phospholipase	phospholipase	NN
cord-018572-e2qq4ngq	384	71	D	D	NNP
cord-018572-e2qq4ngq	384	72	)	)	-RRB-
cord-018572-e2qq4ngq	384	73	.	.	.
cord-018572-e2qq4ngq	385	1	One	one	CD
cord-018572-e2qq4ngq	385	2	obvious	obvious	JJ
cord-018572-e2qq4ngq	385	3	consequence	consequence	NN
cord-018572-e2qq4ngq	385	4	of	of	IN
cord-018572-e2qq4ngq	385	5	having	have	VBG
cord-018572-e2qq4ngq	385	6	a	a	DT
cord-018572-e2qq4ngq	385	7	single	single	JJ
cord-018572-e2qq4ngq	385	8	protein	protein	NN
cord-018572-e2qq4ngq	385	9	with	with	IN
cord-018572-e2qq4ngq	385	10	different	different	JJ
cord-018572-e2qq4ngq	385	11	functions	function	NNS
cord-018572-e2qq4ngq	385	12	is	be	VBZ
cord-018572-e2qq4ngq	385	13	that	that	IN
cord-018572-e2qq4ngq	385	14	the	the	DT
cord-018572-e2qq4ngq	385	15	various	various	JJ
cord-018572-e2qq4ngq	385	16	processes	process	NNS
cord-018572-e2qq4ngq	385	17	can	can	MD
cord-018572-e2qq4ngq	385	18	be	be	VB
cord-018572-e2qq4ngq	385	19	integrated	integrate	VBN
cord-018572-e2qq4ngq	385	20	in	in	IN
cord-018572-e2qq4ngq	385	21	a	a	DT
cord-018572-e2qq4ngq	385	22	simple	simple	JJ
cord-018572-e2qq4ngq	385	23	manner	manner	NN
cord-018572-e2qq4ngq	385	24	.	.	.
cord-018572-e2qq4ngq	386	1	For	for	IN
cord-018572-e2qq4ngq	386	2	example	example	NN
cord-018572-e2qq4ngq	386	3	,	,	,
cord-018572-e2qq4ngq	386	4	the	the	DT
cord-018572-e2qq4ngq	386	5	single	single	JJ
cord-018572-e2qq4ngq	386	6	pool	pool	NN
cord-018572-e2qq4ngq	386	7	of	of	IN
cord-018572-e2qq4ngq	386	8	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	386	9	must	must	MD
cord-018572-e2qq4ngq	386	10	be	be	VB
cord-018572-e2qq4ngq	386	11	distributed	distribute	VBN
cord-018572-e2qq4ngq	386	12	among	among	IN
cord-018572-e2qq4ngq	386	13	all	all	DT
cord-018572-e2qq4ngq	386	14	of	of	IN
cord-018572-e2qq4ngq	386	15	the	the	DT
cord-018572-e2qq4ngq	386	16	different	different	JJ
cord-018572-e2qq4ngq	386	17	GEF	GEF	NNP
cord-018572-e2qq4ngq	386	18	,	,	,
cord-018572-e2qq4ngq	386	19	GAP	gap	NN
cord-018572-e2qq4ngq	386	20	,	,	,
cord-018572-e2qq4ngq	386	21	and	and	CC
cord-018572-e2qq4ngq	386	22	effector	effector	VB
cord-018572-e2qq4ngq	386	23	complexes	complex	NNS
cord-018572-e2qq4ngq	386	24	in	in	IN
cord-018572-e2qq4ngq	386	25	the	the	DT
cord-018572-e2qq4ngq	386	26	cell	cell	NN
cord-018572-e2qq4ngq	386	27	,	,	,
cord-018572-e2qq4ngq	386	28	which	which	WDT
cord-018572-e2qq4ngq	386	29	could	could	MD
cord-018572-e2qq4ngq	386	30	provide	provide	VB
cord-018572-e2qq4ngq	386	31	a	a	DT
cord-018572-e2qq4ngq	386	32	type	type	NN
cord-018572-e2qq4ngq	386	33	of	of	IN
cord-018572-e2qq4ngq	386	34	global	global	JJ
cord-018572-e2qq4ngq	386	35	regulation	regulation	NN
cord-018572-e2qq4ngq	386	36	of	of	IN
cord-018572-e2qq4ngq	386	37	all	all	DT
cord-018572-e2qq4ngq	386	38	of	of	IN
cord-018572-e2qq4ngq	386	39	the	the	DT
cord-018572-e2qq4ngq	386	40	functions	function	NNS
cord-018572-e2qq4ngq	386	41	that	that	WDT
cord-018572-e2qq4ngq	386	42	these	these	DT
cord-018572-e2qq4ngq	386	43	different	different	JJ
cord-018572-e2qq4ngq	386	44	complexes	complex	NNS
cord-018572-e2qq4ngq	386	45	carry	carry	VBP
cord-018572-e2qq4ngq	386	46	out	out	RP
cord-018572-e2qq4ngq	386	47	.	.	.
cord-018572-e2qq4ngq	387	1	In	in	IN
cord-018572-e2qq4ngq	387	2	particular	particular	JJ
cord-018572-e2qq4ngq	387	3	,	,	,
cord-018572-e2qq4ngq	387	4	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	387	5	is	be	VBZ
cord-018572-e2qq4ngq	387	6	involved	involve	VBN
cord-018572-e2qq4ngq	387	7	in	in	IN
cord-018572-e2qq4ngq	387	8	the	the	DT
cord-018572-e2qq4ngq	387	9	recruitment	recruitment	NN
cord-018572-e2qq4ngq	387	10	of	of	IN
cord-018572-e2qq4ngq	387	11	coat	coat	NN
cord-018572-e2qq4ngq	387	12	complexes	complex	NNS
cord-018572-e2qq4ngq	387	13	and	and	CC
cord-018572-e2qq4ngq	387	14	membrane	membrane	NN
cord-018572-e2qq4ngq	387	15	tethers	tether	NNS
cord-018572-e2qq4ngq	387	16	at	at	IN
cord-018572-e2qq4ngq	387	17	the	the	DT
cord-018572-e2qq4ngq	387	18	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	387	19	that	that	WDT
cord-018572-e2qq4ngq	387	20	mediate	mediate	VBP
cord-018572-e2qq4ngq	387	21	vesicular	vesicular	JJ
cord-018572-e2qq4ngq	387	22	trafficking	trafficking	NN
cord-018572-e2qq4ngq	387	23	,	,	,
cord-018572-e2qq4ngq	387	24	and	and	CC
cord-018572-e2qq4ngq	387	25	also	also	RB
cord-018572-e2qq4ngq	387	26	in	in	IN
cord-018572-e2qq4ngq	387	27	lipid	lipid	NN
cord-018572-e2qq4ngq	387	28	droplet	droplet	NN
cord-018572-e2qq4ngq	387	29	metabolism	metabolism	NN
cord-018572-e2qq4ngq	387	30	and	and	CC
cord-018572-e2qq4ngq	387	31	in	in	IN
cord-018572-e2qq4ngq	387	32	recruitment	recruitment	NN
cord-018572-e2qq4ngq	387	33	of	of	IN
cord-018572-e2qq4ngq	387	34	at	at	RB
cord-018572-e2qq4ngq	387	35	least	least	RBS
cord-018572-e2qq4ngq	387	36	three	three	CD
cord-018572-e2qq4ngq	387	37	lipid	lipid	NN
cord-018572-e2qq4ngq	387	38	transfer	transfer	NN
cord-018572-e2qq4ngq	387	39	proteins	protein	NNS
cord-018572-e2qq4ngq	387	40	that	that	WDT
cord-018572-e2qq4ngq	387	41	mediate	mediate	VBP
cord-018572-e2qq4ngq	387	42	non	non	JJ
cord-018572-e2qq4ngq	387	43	-	-	JJ
cord-018572-e2qq4ngq	387	44	vesicular	vesicular	JJ
cord-018572-e2qq4ngq	387	45	lipid	lipid	NN
cord-018572-e2qq4ngq	387	46	trafficking	trafficking	NN
cord-018572-e2qq4ngq	387	47	in	in	IN
cord-018572-e2qq4ngq	387	48	cells	cell	NNS
cord-018572-e2qq4ngq	387	49	.	.	.
cord-018572-e2qq4ngq	388	1	Hence	hence	RB
cord-018572-e2qq4ngq	388	2	a	a	DT
cord-018572-e2qq4ngq	388	3	fundamental	fundamental	JJ
cord-018572-e2qq4ngq	388	4	role	role	NN
cord-018572-e2qq4ngq	388	5	of	of	IN
cord-018572-e2qq4ngq	388	6	the	the	DT
cord-018572-e2qq4ngq	388	7	Arf	Arf	NNP
cord-018572-e2qq4ngq	388	8	proteins	protein	NNS
cord-018572-e2qq4ngq	388	9	may	may	MD
cord-018572-e2qq4ngq	388	10	be	be	VB
cord-018572-e2qq4ngq	388	11	in	in	IN
cord-018572-e2qq4ngq	388	12	coordinating	coordinate	VBG
cord-018572-e2qq4ngq	388	13	both	both	CC
cord-018572-e2qq4ngq	388	14	vesicular	vesicular	JJ
cord-018572-e2qq4ngq	388	15	and	and	CC
cord-018572-e2qq4ngq	388	16	non	non	JJ
cord-018572-e2qq4ngq	388	17	-	-	JJ
cord-018572-e2qq4ngq	388	18	vesicular	vesicular	JJ
cord-018572-e2qq4ngq	388	19	lipid	lipid	NN
cord-018572-e2qq4ngq	388	20	trafficking	traffic	VBG
cord-018572-e2qq4ngq	388	21	pathways	pathway	NNS
cord-018572-e2qq4ngq	388	22	in	in	IN
cord-018572-e2qq4ngq	388	23	the	the	DT
cord-018572-e2qq4ngq	388	24	cell	cell	NN
cord-018572-e2qq4ngq	388	25	.	.	.
cord-018572-e2qq4ngq	389	1	The	the	DT
cord-018572-e2qq4ngq	389	2	capping	cap	VBG
cord-018572-e2qq4ngq	389	3	domain	domain	NN
cord-018572-e2qq4ngq	389	4	in	in	IN
cord-018572-e2qq4ngq	389	5	RalF	RalF	NNP
cord-018572-e2qq4ngq	389	6	regulates	regulate	VBZ
cord-018572-e2qq4ngq	389	7	effector	effector	NN
cord-018572-e2qq4ngq	389	8	functions	function	NNS
cord-018572-e2qq4ngq	389	9	Hepatitis	Hepatitis	NNP
cord-018572-e2qq4ngq	389	10	C	C	NNP
cord-018572-e2qq4ngq	389	11	virus	virus	NN
cord-018572-e2qq4ngq	389	12	and	and	CC
cord-018572-e2qq4ngq	389	13	host	host	NN
cord-018572-e2qq4ngq	389	14	cell	cell	NN
cord-018572-e2qq4ngq	389	15	lipids	lipid	NNS
cord-018572-e2qq4ngq	389	16	:	:	:
cord-018572-e2qq4ngq	389	17	an	an	DT
cord-018572-e2qq4ngq	389	18	intimate	intimate	JJ
cord-018572-e2qq4ngq	389	19	connection	connection	NN
cord-018572-e2qq4ngq	390	1	The	the	DT
cord-018572-e2qq4ngq	390	2	structure	structure	NN
cord-018572-e2qq4ngq	390	3	of	of	IN
cord-018572-e2qq4ngq	390	4	RalF	RalF	NNP
cord-018572-e2qq4ngq	390	5	,	,	,
cord-018572-e2qq4ngq	390	6	an	an	DT
cord-018572-e2qq4ngq	390	7	ADP	adp	NN
cord-018572-e2qq4ngq	390	8	-	-	HYPH
cord-018572-e2qq4ngq	390	9	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	390	10	factor	factor	NN
cord-018572-e2qq4ngq	390	11	guanine	guanine	NN
cord-018572-e2qq4ngq	390	12	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	390	13	exchange	exchange	NN
cord-018572-e2qq4ngq	390	14	factor	factor	NN
cord-018572-e2qq4ngq	390	15	from	from	IN
cord-018572-e2qq4ngq	390	16	Legionella	Legionella	NNP
cord-018572-e2qq4ngq	390	17	pneumophila	pneumophila	NN
cord-018572-e2qq4ngq	390	18	,	,	,
cord-018572-e2qq4ngq	390	19	reveals	reveal	VBZ
cord-018572-e2qq4ngq	390	20	the	the	DT
cord-018572-e2qq4ngq	390	21	presence	presence	NN
cord-018572-e2qq4ngq	390	22	of	of	IN
cord-018572-e2qq4ngq	390	23	a	a	DT
cord-018572-e2qq4ngq	390	24	cap	cap	NN
cord-018572-e2qq4ngq	390	25	over	over	IN
cord-018572-e2qq4ngq	390	26	the	the	DT
cord-018572-e2qq4ngq	390	27	active	active	JJ
cord-018572-e2qq4ngq	390	28	site	site	NN
cord-018572-e2qq4ngq	390	29	N	n	CD
cord-018572-e2qq4ngq	390	30	-	-	HYPH
cord-018572-e2qq4ngq	390	31	terminal	terminal	JJ
cord-018572-e2qq4ngq	390	32	hydrophobic	hydrophobic	JJ
cord-018572-e2qq4ngq	390	33	residues	residue	NNS
cord-018572-e2qq4ngq	390	34	of	of	IN
cord-018572-e2qq4ngq	390	35	the	the	DT
cord-018572-e2qq4ngq	390	36	G	g	NN
cord-018572-e2qq4ngq	390	37	-	-	HYPH
cord-018572-e2qq4ngq	390	38	protein	protein	NN
cord-018572-e2qq4ngq	390	39	ADP	ADP	NNP
cord-018572-e2qq4ngq	390	40	-	-	HYPH
cord-018572-e2qq4ngq	390	41	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	390	42	factor-1	factor-1	NNP
cord-018572-e2qq4ngq	390	43	insert	insert	VB
cord-018572-e2qq4ngq	390	44	into	into	IN
cord-018572-e2qq4ngq	390	45	membrane	membrane	NN
cord-018572-e2qq4ngq	390	46	phospholipids	phospholipid	NNS
cord-018572-e2qq4ngq	390	47	upon	upon	IN
cord-018572-e2qq4ngq	390	48	GDP	GDP	NNP
cord-018572-e2qq4ngq	390	49	to	to	IN
cord-018572-e2qq4ngq	390	50	GTP	GTP	NNP
cord-018572-e2qq4ngq	390	51	exchange	exchange	NN
cord-018572-e2qq4ngq	390	52	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	390	53	and	and	CC
cord-018572-e2qq4ngq	390	54	microtubules	microtubule	VBZ
cord-018572-e2qq4ngq	390	55	in	in	IN
cord-018572-e2qq4ngq	390	56	adhesion	adhesion	NN
cord-018572-e2qq4ngq	390	57	-	-	HYPH
cord-018572-e2qq4ngq	390	58	dependent	dependent	JJ
cord-018572-e2qq4ngq	390	59	trafficking	trafficking	NN
cord-018572-e2qq4ngq	390	60	of	of	IN
cord-018572-e2qq4ngq	390	61	lipid	lipid	NN
cord-018572-e2qq4ngq	390	62	rafts	raft	NNS
cord-018572-e2qq4ngq	391	1	The	the	DT
cord-018572-e2qq4ngq	391	2	COPI	COPI	NNP
cord-018572-e2qq4ngq	391	3	system	system	NN
cord-018572-e2qq4ngq	391	4	:	:	:
cord-018572-e2qq4ngq	391	5	molecular	molecular	JJ
cord-018572-e2qq4ngq	391	6	mechanisms	mechanism	NNS
cord-018572-e2qq4ngq	391	7	and	and	CC
cord-018572-e2qq4ngq	391	8	function	function	NN
cord-018572-e2qq4ngq	392	1	A	a	DT
cord-018572-e2qq4ngq	392	2	phosphatidylinositol-3-kinase	phosphatidylinositol-3-kinase	JJ
cord-018572-e2qq4ngq	392	3	-	-	HYPH
cord-018572-e2qq4ngq	392	4	dependent	dependent	JJ
cord-018572-e2qq4ngq	392	5	signal	signal	NN
cord-018572-e2qq4ngq	392	6	transition	transition	NN
cord-018572-e2qq4ngq	392	7	regulates	regulate	VBZ
cord-018572-e2qq4ngq	392	8	ARF1	ARF1	NNP
cord-018572-e2qq4ngq	392	9	and	and	CC
cord-018572-e2qq4ngq	392	10	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	392	11	during	during	IN
cord-018572-e2qq4ngq	392	12	Fcgamma	Fcgamma	NNP
cord-018572-e2qq4ngq	392	13	receptor	receptor	NN
cord-018572-e2qq4ngq	392	14	-	-	HYPH
cord-018572-e2qq4ngq	392	15	mediated	mediate	VBN
cord-018572-e2qq4ngq	392	16	phagocytosis	phagocytosis	NN
cord-018572-e2qq4ngq	392	17	COPI	COPI	NNP
cord-018572-e2qq4ngq	392	18	complex	complex	JJ
cord-018572-e2qq4ngq	392	19	is	be	VBZ
cord-018572-e2qq4ngq	392	20	a	a	DT
cord-018572-e2qq4ngq	392	21	regulator	regulator	NN
cord-018572-e2qq4ngq	392	22	of	of	IN
cord-018572-e2qq4ngq	392	23	lipid	lipid	NN
cord-018572-e2qq4ngq	392	24	homeostasis	homeostasis	NN
cord-018572-e2qq4ngq	392	25	A	a	DT
cord-018572-e2qq4ngq	392	26	critical	critical	JJ
cord-018572-e2qq4ngq	392	27	role	role	NN
cord-018572-e2qq4ngq	392	28	of	of	IN
cord-018572-e2qq4ngq	392	29	a	a	DT
cord-018572-e2qq4ngq	392	30	cellular	cellular	JJ
cord-018572-e2qq4ngq	392	31	membrane	membrane	NN
cord-018572-e2qq4ngq	392	32	traffic	traffic	NN
cord-018572-e2qq4ngq	392	33	protein	protein	NN
cord-018572-e2qq4ngq	392	34	in	in	IN
cord-018572-e2qq4ngq	392	35	poliovirus	poliovirus	NN
cord-018572-e2qq4ngq	392	36	RNA	RNA	NNP
cord-018572-e2qq4ngq	392	37	replication	replication	NN
cord-018572-e2qq4ngq	392	38	ADP	ADP	NNP
cord-018572-e2qq4ngq	392	39	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	392	40	factors	factor	VBZ
cord-018572-e2qq4ngq	392	41	1	1	CD
cord-018572-e2qq4ngq	392	42	and	and	CC
cord-018572-e2qq4ngq	392	43	4	4	CD
cord-018572-e2qq4ngq	392	44	and	and	CC
cord-018572-e2qq4ngq	392	45	group	group	NN
cord-018572-e2qq4ngq	392	46	VIA	VIA	NNP
cord-018572-e2qq4ngq	392	47	phospholipase	phospholipase	NN
cord-018572-e2qq4ngq	392	48	A(2	A(2	NNP
cord-018572-e2qq4ngq	392	49	)	)	-RRB-
cord-018572-e2qq4ngq	393	1	regulate	regulate	VB
cord-018572-e2qq4ngq	393	2	morphology	morphology	NN
cord-018572-e2qq4ngq	393	3	and	and	CC
cord-018572-e2qq4ngq	393	4	intraorganellar	intraorganellar	JJ
cord-018572-e2qq4ngq	393	5	traffic	traffic	NN
cord-018572-e2qq4ngq	393	6	in	in	IN
cord-018572-e2qq4ngq	393	7	the	the	DT
cord-018572-e2qq4ngq	393	8	endoplasmic	endoplasmic	NN
cord-018572-e2qq4ngq	393	9	reticulum	reticulum	NN
cord-018572-e2qq4ngq	393	10	-	-	:
cord-018572-e2qq4ngq	393	11	Golgi	golgi	NN
cord-018572-e2qq4ngq	393	12	intermediate	intermediate	JJ
cord-018572-e2qq4ngq	393	13	compartment	compartment	NN
cord-018572-e2qq4ngq	393	14	Curvature	curvature	NN
cord-018572-e2qq4ngq	393	15	,	,	,
cord-018572-e2qq4ngq	393	16	lipid	lipid	NN
cord-018572-e2qq4ngq	393	17	packing	packing	NN
cord-018572-e2qq4ngq	393	18	,	,	,
cord-018572-e2qq4ngq	393	19	and	and	CC
cord-018572-e2qq4ngq	393	20	electrostatics	electrostatic	NNS
cord-018572-e2qq4ngq	393	21	of	of	IN
cord-018572-e2qq4ngq	393	22	membrane	membrane	NN
cord-018572-e2qq4ngq	393	23	organelles	organelle	NNS
cord-018572-e2qq4ngq	393	24	:	:	:
cord-018572-e2qq4ngq	393	25	defining	define	VBG
cord-018572-e2qq4ngq	393	26	cellular	cellular	JJ
cord-018572-e2qq4ngq	393	27	territories	territory	NNS
cord-018572-e2qq4ngq	393	28	in	in	IN
cord-018572-e2qq4ngq	393	29	determining	determine	VBG
cord-018572-e2qq4ngq	393	30	specificity	specificity	NN
cord-018572-e2qq4ngq	393	31	Lipid	lipid	NN
cord-018572-e2qq4ngq	393	32	packing	packing	NN
cord-018572-e2qq4ngq	393	33	sensed	sense	VBN
cord-018572-e2qq4ngq	393	34	by	by	IN
cord-018572-e2qq4ngq	393	35	ArfGAP1	arfgap1	NN
cord-018572-e2qq4ngq	393	36	couples	couple	NNS
cord-018572-e2qq4ngq	394	1	COPI	COPI	NNP
cord-018572-e2qq4ngq	394	2	coat	coat	NN
cord-018572-e2qq4ngq	394	3	disassembly	disassembly	NN
cord-018572-e2qq4ngq	394	4	to	to	IN
cord-018572-e2qq4ngq	395	1	membrane	membrane	NN
cord-018572-e2qq4ngq	395	2	bilayer	bilayer	NN
cord-018572-e2qq4ngq	395	3	curvature	curvature	NN
cord-018572-e2qq4ngq	395	4	ArfGAP1	ArfGAP1	NNP
cord-018572-e2qq4ngq	395	5	responds	respond	VBZ
cord-018572-e2qq4ngq	395	6	to	to	IN
cord-018572-e2qq4ngq	395	7	membrane	membrane	NN
cord-018572-e2qq4ngq	395	8	curvature	curvature	NN
cord-018572-e2qq4ngq	395	9	through	through	IN
cord-018572-e2qq4ngq	395	10	the	the	DT
cord-018572-e2qq4ngq	395	11	folding	folding	NN
cord-018572-e2qq4ngq	395	12	of	of	IN
cord-018572-e2qq4ngq	395	13	a	a	DT
cord-018572-e2qq4ngq	395	14	lipid	lipid	NN
cord-018572-e2qq4ngq	395	15	packing	packing	NN
cord-018572-e2qq4ngq	395	16	sensor	sensor	NN
cord-018572-e2qq4ngq	395	17	motif	motif	NN
cord-018572-e2qq4ngq	395	18	Cytohesins	cytohesin	NNS
cord-018572-e2qq4ngq	395	19	are	be	VBP
cord-018572-e2qq4ngq	395	20	cytoplasmic	cytoplasmic	JJ
cord-018572-e2qq4ngq	395	21	ErbB	ErbB	NNP
cord-018572-e2qq4ngq	395	22	receptor	receptor	NN
cord-018572-e2qq4ngq	395	23	activators	activator	NNS
cord-018572-e2qq4ngq	395	24	Coat	coat	NN
cord-018572-e2qq4ngq	395	25	proteins	protein	NNS
cord-018572-e2qq4ngq	395	26	:	:	:
cord-018572-e2qq4ngq	395	27	shaping	shape	VBG
cord-018572-e2qq4ngq	395	28	membrane	membrane	NN
cord-018572-e2qq4ngq	395	29	transport	transport	NN
cord-018572-e2qq4ngq	395	30	Targeting	targeting	NN
cord-018572-e2qq4ngq	395	31	of	of	IN
cord-018572-e2qq4ngq	395	32	the	the	DT
cord-018572-e2qq4ngq	395	33	Arf	Arf	NNP
cord-018572-e2qq4ngq	395	34	-	-	HYPH
cord-018572-e2qq4ngq	395	35	GEF	GEF	NNP
cord-018572-e2qq4ngq	395	36	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	395	37	to	to	IN
cord-018572-e2qq4ngq	395	38	lipid	lipid	NN
cord-018572-e2qq4ngq	395	39	droplets	droplet	NNS
cord-018572-e2qq4ngq	395	40	and	and	CC
cord-018572-e2qq4ngq	395	41	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	395	42	membranes	membrane	NNS
cord-018572-e2qq4ngq	395	43	Regulation	Regulation	NNP
cord-018572-e2qq4ngq	395	44	of	of	IN
cord-018572-e2qq4ngq	395	45	ras	ras	NNP
cord-018572-e2qq4ngq	395	46	signaling	signal	VBG
cord-018572-e2qq4ngq	395	47	dynamics	dynamic	NNS
cord-018572-e2qq4ngq	395	48	by	by	IN
cord-018572-e2qq4ngq	395	49	Sos	Sos	NNP
cord-018572-e2qq4ngq	395	50	-	-	HYPH
cord-018572-e2qq4ngq	395	51	mediated	mediate	VBN
cord-018572-e2qq4ngq	395	52	positive	positive	JJ
cord-018572-e2qq4ngq	395	53	feedback	feedback	NN
cord-018572-e2qq4ngq	395	54	ADP	adp	NN
cord-018572-e2qq4ngq	395	55	-	-	HYPH
cord-018572-e2qq4ngq	395	56	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	395	57	factor	factor	NN
cord-018572-e2qq4ngq	395	58	,	,	,
cord-018572-e2qq4ngq	395	59	a	a	DT
cord-018572-e2qq4ngq	395	60	small	small	JJ
cord-018572-e2qq4ngq	395	61	GTP	gtp	NN
cord-018572-e2qq4ngq	395	62	-	-	HYPH
cord-018572-e2qq4ngq	395	63	dependent	dependent	JJ
cord-018572-e2qq4ngq	395	64	regulatory	regulatory	JJ
cord-018572-e2qq4ngq	395	65	protein	protein	NN
cord-018572-e2qq4ngq	395	66	,	,	,
cord-018572-e2qq4ngq	395	67	stimulates	stimulate	VBZ
cord-018572-e2qq4ngq	395	68	phospholipase	phospholipase	NN
cord-018572-e2qq4ngq	395	69	D	d	NN
cord-018572-e2qq4ngq	395	70	activity	activity	NN
cord-018572-e2qq4ngq	395	71	Bilaterally	bilaterally	RB
cord-018572-e2qq4ngq	395	72	cleft	cleft	JJ
cord-018572-e2qq4ngq	395	73	lip	lip	NN
cord-018572-e2qq4ngq	395	74	and	and	CC
cord-018572-e2qq4ngq	395	75	bilateral	bilateral	JJ
cord-018572-e2qq4ngq	395	76	thumb	thumb	NN
cord-018572-e2qq4ngq	395	77	polydactyly	polydactyly	XX
cord-018572-e2qq4ngq	395	78	with	with	IN
cord-018572-e2qq4ngq	395	79	triphalangeal	triphalangeal	NN
cord-018572-e2qq4ngq	395	80	component	component	NN
cord-018572-e2qq4ngq	395	81	in	in	IN
cord-018572-e2qq4ngq	395	82	a	a	DT
cord-018572-e2qq4ngq	395	83	patient	patient	NN
cord-018572-e2qq4ngq	395	84	with	with	IN
cord-018572-e2qq4ngq	395	85	two	two	CD
cord-018572-e2qq4ngq	395	86	de	de	FW
cord-018572-e2qq4ngq	395	87	novo	novo	NNP
cord-018572-e2qq4ngq	395	88	deletions	deletion	NNS
cord-018572-e2qq4ngq	395	89	of	of	IN
cord-018572-e2qq4ngq	395	90	HSA	HSA	NNP
cord-018572-e2qq4ngq	395	91	4q32	4q32	CD
cord-018572-e2qq4ngq	395	92	and	and	CC
cord-018572-e2qq4ngq	395	93	4q34	4q34	CD
cord-018572-e2qq4ngq	395	94	involving	involve	VBG
cord-018572-e2qq4ngq	395	95	PDGFC	PDGFC	NNP
cord-018572-e2qq4ngq	395	96	,	,	,
cord-018572-e2qq4ngq	395	97	GRIA2	GRIA2	NNP
cord-018572-e2qq4ngq	395	98	,	,	,
cord-018572-e2qq4ngq	395	99	and	and	CC
cord-018572-e2qq4ngq	395	100	FBXO8	fbxo8	XX
cord-018572-e2qq4ngq	395	101	genes	gene	NNS
cord-018572-e2qq4ngq	395	102	Regulation	Regulation	NNP
cord-018572-e2qq4ngq	395	103	of	of	IN
cord-018572-e2qq4ngq	395	104	Arf	Arf	NNP
cord-018572-e2qq4ngq	395	105	activation	activation	NN
cord-018572-e2qq4ngq	395	106	:	:	:
cord-018572-e2qq4ngq	395	107	the	the	DT
cord-018572-e2qq4ngq	395	108	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	395	109	family	family	NN
cord-018572-e2qq4ngq	395	110	of	of	IN
cord-018572-e2qq4ngq	395	111	guanine	guanine	NN
cord-018572-e2qq4ngq	395	112	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	395	113	exchange	exchange	NN
cord-018572-e2qq4ngq	395	114	factors	factor	NNS
cord-018572-e2qq4ngq	396	1	A	a	DT
cord-018572-e2qq4ngq	396	2	human	human	JJ
cord-018572-e2qq4ngq	396	3	exchange	exchange	NN
cord-018572-e2qq4ngq	396	4	factor	factor	NN
cord-018572-e2qq4ngq	396	5	for	for	IN
cord-018572-e2qq4ngq	396	6	ARF	arf	NN
cord-018572-e2qq4ngq	396	7	contains	contain	VBZ
cord-018572-e2qq4ngq	396	8	Sec7-and	Sec7-and	NNP
cord-018572-e2qq4ngq	396	9	pleckstrin	pleckstrin	NN
cord-018572-e2qq4ngq	396	10	-	-	HYPH
cord-018572-e2qq4ngq	396	11	homology	homology	NN
cord-018572-e2qq4ngq	396	12	domains	domain	NNS
cord-018572-e2qq4ngq	396	13	Toward	toward	IN
cord-018572-e2qq4ngq	396	14	a	a	DT
cord-018572-e2qq4ngq	396	15	structural	structural	JJ
cord-018572-e2qq4ngq	396	16	understanding	understanding	NN
cord-018572-e2qq4ngq	396	17	of	of	IN
cord-018572-e2qq4ngq	396	18	arf	arf	NNP
cord-018572-e2qq4ngq	396	19	family	family	NN
cord-018572-e2qq4ngq	396	20	:	:	:
cord-018572-e2qq4ngq	396	21	effector	effector	VB
cord-018572-e2qq4ngq	396	22	specificity	specificity	NN
cord-018572-e2qq4ngq	396	23	Syt1p	Syt1p	NNP
cord-018572-e2qq4ngq	396	24	promotes	promote	VBZ
cord-018572-e2qq4ngq	396	25	activation	activation	NN
cord-018572-e2qq4ngq	396	26	of	of	IN
cord-018572-e2qq4ngq	396	27	Arl1p	arl1p	RB
cord-018572-e2qq4ngq	396	28	at	at	IN
cord-018572-e2qq4ngq	396	29	the	the	DT
cord-018572-e2qq4ngq	396	30	late	late	JJ
cord-018572-e2qq4ngq	396	31	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	396	32	to	to	TO
cord-018572-e2qq4ngq	396	33	recruit	recruit	VB
cord-018572-e2qq4ngq	396	34	Imh1p	imh1p	IN
cord-018572-e2qq4ngq	396	35	Characterization	characterization	NN
cord-018572-e2qq4ngq	396	36	of	of	IN
cord-018572-e2qq4ngq	396	37	class	class	NN
cord-018572-e2qq4ngq	396	38	I	i	NN
cord-018572-e2qq4ngq	396	39	and	and	CC
cord-018572-e2qq4ngq	396	40	II	II	NNP
cord-018572-e2qq4ngq	396	41	ADP	ADP	NNP
cord-018572-e2qq4ngq	396	42	-	-	HYPH
cord-018572-e2qq4ngq	396	43	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	396	44	factors	factor	NNS
cord-018572-e2qq4ngq	396	45	(	(	-LRB-
cord-018572-e2qq4ngq	396	46	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	396	47	)	)	-RRB-
cord-018572-e2qq4ngq	396	48	in	in	IN
cord-018572-e2qq4ngq	396	49	live	live	JJ
cord-018572-e2qq4ngq	396	50	cells	cell	NNS
cord-018572-e2qq4ngq	396	51	:	:	:
cord-018572-e2qq4ngq	397	1	GDP	gdp	NN
cord-018572-e2qq4ngq	397	2	-	-	HYPH
cord-018572-e2qq4ngq	397	3	bound	bind	VBN
cord-018572-e2qq4ngq	397	4	class	class	NN
cord-018572-e2qq4ngq	397	5	II	II	NNP
cord-018572-e2qq4ngq	397	6	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	397	7	associate	associate	JJ
cord-018572-e2qq4ngq	397	8	with	with	IN
cord-018572-e2qq4ngq	397	9	the	the	DT
cord-018572-e2qq4ngq	397	10	ER	ER	NNP
cord-018572-e2qq4ngq	397	11	-	-	HYPH
cord-018572-e2qq4ngq	397	12	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	397	13	intermediate	intermediate	JJ
cord-018572-e2qq4ngq	397	14	compartment	compartment	NN
cord-018572-e2qq4ngq	397	15	independently	independently	RB
cord-018572-e2qq4ngq	397	16	of	of	IN
cord-018572-e2qq4ngq	397	17	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	398	1	Unfolded	unfold	VBN
cord-018572-e2qq4ngq	398	2	protein	protein	NN
cord-018572-e2qq4ngq	398	3	response	response	NN
cord-018572-e2qq4ngq	398	4	and	and	CC
cord-018572-e2qq4ngq	398	5	cell	cell	NN
cord-018572-e2qq4ngq	398	6	death	death	NN
cord-018572-e2qq4ngq	398	7	after	after	IN
cord-018572-e2qq4ngq	398	8	depletion	depletion	NN
cord-018572-e2qq4ngq	398	9	of	of	IN
cord-018572-e2qq4ngq	398	10	brefeldin	brefeldin	NNP
cord-018572-e2qq4ngq	399	1	A	a	LS
cord-018572-e2qq4ngq	399	2	-	-	HYPH
cord-018572-e2qq4ngq	399	3	inhibited	inhibited	JJ
cord-018572-e2qq4ngq	399	4	guanine	guanine	NN
cord-018572-e2qq4ngq	399	5	nucleotideexchange	nucleotideexchange	NN
cord-018572-e2qq4ngq	399	6	protein	protein	NN
cord-018572-e2qq4ngq	399	7	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	399	8	Phospholipase	Phospholipase	NNP
cord-018572-e2qq4ngq	399	9	D	D	NNP
cord-018572-e2qq4ngq	399	10	:	:	:
cord-018572-e2qq4ngq	399	11	a	a	DT
cord-018572-e2qq4ngq	399	12	downstream	downstream	JJ
cord-018572-e2qq4ngq	399	13	effector	effector	NN
cord-018572-e2qq4ngq	399	14	of	of	IN
cord-018572-e2qq4ngq	399	15	ARF	arf	NN
cord-018572-e2qq4ngq	399	16	in	in	IN
cord-018572-e2qq4ngq	399	17	granulocytes	granulocyte	NNS
cord-018572-e2qq4ngq	399	18	Active	active	JJ
cord-018572-e2qq4ngq	399	19	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	399	20	recruits	recruit	VBZ
cord-018572-e2qq4ngq	399	21	ARNO	ARNO	NNP
cord-018572-e2qq4ngq	399	22	/	/	SYM
cord-018572-e2qq4ngq	399	23	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	399	24	GEFs	GEFs	NNP
cord-018572-e2qq4ngq	399	25	to	to	IN
cord-018572-e2qq4ngq	399	26	the	the	DT
cord-018572-e2qq4ngq	399	27	PM	PM	NNP
cord-018572-e2qq4ngq	399	28	by	by	IN
cord-018572-e2qq4ngq	399	29	binding	bind	VBG
cord-018572-e2qq4ngq	399	30	their	-PRON-	PRP$
cord-018572-e2qq4ngq	399	31	PH	PH	NNP
cord-018572-e2qq4ngq	399	32	domains	domain	NNS
cord-018572-e2qq4ngq	399	33	Lipid	Lipid	NNP
cord-018572-e2qq4ngq	399	34	droplet	droplet	NN
cord-018572-e2qq4ngq	399	35	binding	binding	NN
cord-018572-e2qq4ngq	399	36	and	and	CC
cord-018572-e2qq4ngq	399	37	oligomerization	oligomerization	NN
cord-018572-e2qq4ngq	399	38	properties	property	NNS
cord-018572-e2qq4ngq	399	39	of	of	IN
cord-018572-e2qq4ngq	399	40	the	the	DT
cord-018572-e2qq4ngq	399	41	Parkinson	Parkinson	NNP
cord-018572-e2qq4ngq	399	42	's	's	POS
cord-018572-e2qq4ngq	399	43	disease	disease	NN
cord-018572-e2qq4ngq	399	44	protein	protein	NNP
cord-018572-e2qq4ngq	399	45	alpha	alpha	NNP
cord-018572-e2qq4ngq	399	46	-	-	HYPH
cord-018572-e2qq4ngq	399	47	synuclein	synuclein	NNP
cord-018572-e2qq4ngq	399	48	Phylogenetic	Phylogenetic	NNP
cord-018572-e2qq4ngq	399	49	analysis	analysis	NN
cord-018572-e2qq4ngq	399	50	of	of	IN
cord-018572-e2qq4ngq	399	51	Sec7-domaincontaining	sec7-domaincontaine	VBG
cord-018572-e2qq4ngq	399	52	Arf	Arf	NNP
cord-018572-e2qq4ngq	399	53	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	399	54	exchangers	exchanger	NNS
cord-018572-e2qq4ngq	400	1	The	the	DT
cord-018572-e2qq4ngq	400	2	ARF1	ARF1	NNP
cord-018572-e2qq4ngq	400	3	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	400	4	-	-	HYPH
cord-018572-e2qq4ngq	400	5	activating	activate	VBG
cord-018572-e2qq4ngq	400	6	protein	protein	NN
cord-018572-e2qq4ngq	400	7	:	:	:
cord-018572-e2qq4ngq	400	8	zinc	zinc	NN
cord-018572-e2qq4ngq	400	9	finger	finger	NN
cord-018572-e2qq4ngq	400	10	motif	motif	NN
cord-018572-e2qq4ngq	400	11	and	and	CC
cord-018572-e2qq4ngq	400	12	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	400	13	complex	complex	JJ
cord-018572-e2qq4ngq	400	14	localization	localization	NN
cord-018572-e2qq4ngq	401	1	Glycosphingolipid	Glycosphingolipid	NNP
cord-018572-e2qq4ngq	401	2	synthesis	synthesis	NN
cord-018572-e2qq4ngq	401	3	requires	require	VBZ
cord-018572-e2qq4ngq	401	4	FAPP2	fapp2	NN
cord-018572-e2qq4ngq	401	5	transfer	transfer	NN
cord-018572-e2qq4ngq	401	6	of	of	IN
cord-018572-e2qq4ngq	401	7	glucosylceramide	glucosylceramide	NNP
cord-018572-e2qq4ngq	401	8	Evolution	evolution	NN
cord-018572-e2qq4ngq	401	9	of	of	IN
cord-018572-e2qq4ngq	401	10	the	the	DT
cord-018572-e2qq4ngq	401	11	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	401	12	membrane	membrane	NN
cord-018572-e2qq4ngq	401	13	-	-	HYPH
cord-018572-e2qq4ngq	401	14	trafficking	traffic	VBG
cord-018572-e2qq4ngq	401	15	system	system	NN
cord-018572-e2qq4ngq	401	16	:	:	:
cord-018572-e2qq4ngq	401	17	origin	origin	NN
cord-018572-e2qq4ngq	401	18	,	,	,
cord-018572-e2qq4ngq	401	19	tempo	tempo	NNP
cord-018572-e2qq4ngq	401	20	and	and	CC
cord-018572-e2qq4ngq	401	21	mode	mode	VB
cord-018572-e2qq4ngq	401	22	ADP	ADP	NNP
cord-018572-e2qq4ngq	401	23	-	-	HYPH
cord-018572-e2qq4ngq	401	24	ribosylated	ribosylate	VBN
cord-018572-e2qq4ngq	401	25	proteins	protein	NNS
cord-018572-e2qq4ngq	401	26	as	as	IN
cord-018572-e2qq4ngq	401	27	old	old	JJ
cord-018572-e2qq4ngq	401	28	and	and	CC
cord-018572-e2qq4ngq	401	29	new	new	JJ
cord-018572-e2qq4ngq	401	30	drug	drug	NN
cord-018572-e2qq4ngq	401	31	targets	target	NNS
cord-018572-e2qq4ngq	401	32	for	for	IN
cord-018572-e2qq4ngq	401	33	anticancer	anticancer	JJ
cord-018572-e2qq4ngq	401	34	therapy	therapy	NN
cord-018572-e2qq4ngq	401	35	:	:	:
cord-018572-e2qq4ngq	402	1	the	the	DT
cord-018572-e2qq4ngq	402	2	example	example	NN
cord-018572-e2qq4ngq	402	3	of	of	IN
cord-018572-e2qq4ngq	402	4	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	402	5	Recent	Recent	NNP
cord-018572-e2qq4ngq	402	6	insights	insight	NNS
cord-018572-e2qq4ngq	402	7	into	into	IN
cord-018572-e2qq4ngq	402	8	the	the	DT
cord-018572-e2qq4ngq	402	9	mechanisms	mechanism	NNS
cord-018572-e2qq4ngq	402	10	of	of	IN
cord-018572-e2qq4ngq	402	11	Chlamydia	Chlamydia	NNP
cord-018572-e2qq4ngq	402	12	entry	entry	NN
cord-018572-e2qq4ngq	402	13	PI	pi	NN
cord-018572-e2qq4ngq	402	14	-	-	HYPH
cord-018572-e2qq4ngq	402	15	loting	lot	VBG
cord-018572-e2qq4ngq	402	16	membrane	membrane	NN
cord-018572-e2qq4ngq	402	17	traffic	traffic	NN
cord-018572-e2qq4ngq	402	18	Protein	protein	NN
cord-018572-e2qq4ngq	402	19	-	-	HYPH
cord-018572-e2qq4ngq	402	20	lipid	lipid	NN
cord-018572-e2qq4ngq	402	21	interactions	interaction	NNS
cord-018572-e2qq4ngq	402	22	in	in	IN
cord-018572-e2qq4ngq	402	23	membrane	membrane	NN
cord-018572-e2qq4ngq	402	24	trafficking	traffic	VBG
cord-018572-e2qq4ngq	402	25	at	at	IN
cord-018572-e2qq4ngq	402	26	the	the	DT
cord-018572-e2qq4ngq	402	27	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	402	28	complex	complex	NN
cord-018572-e2qq4ngq	402	29	A	a	DT
cord-018572-e2qq4ngq	402	30	COPI	COPI	NNP
cord-018572-e2qq4ngq	402	31	coat	coat	NN
cord-018572-e2qq4ngq	402	32	subunit	subunit	NN
cord-018572-e2qq4ngq	402	33	interacts	interact	VBZ
cord-018572-e2qq4ngq	402	34	directly	directly	RB
cord-018572-e2qq4ngq	402	35	with	with	IN
cord-018572-e2qq4ngq	402	36	an	an	DT
cord-018572-e2qq4ngq	402	37	early	early	JJ
cord-018572-e2qq4ngq	402	38	-	-	HYPH
cord-018572-e2qq4ngq	402	39	Golgi	golgi	NN
cord-018572-e2qq4ngq	402	40	localized	localize	VBN
cord-018572-e2qq4ngq	402	41	Arf	Arf	NNP
cord-018572-e2qq4ngq	402	42	exchange	exchange	NN
cord-018572-e2qq4ngq	402	43	factor	factor	NN
cord-018572-e2qq4ngq	402	44	Rhodopsin	Rhodopsin	NNP
cord-018572-e2qq4ngq	402	45	C	C	NNP
cord-018572-e2qq4ngq	402	46	terminus	terminus	NN
cord-018572-e2qq4ngq	402	47	,	,	,
cord-018572-e2qq4ngq	402	48	the	the	DT
cord-018572-e2qq4ngq	402	49	site	site	NN
cord-018572-e2qq4ngq	402	50	of	of	IN
cord-018572-e2qq4ngq	402	51	mutations	mutation	NNS
cord-018572-e2qq4ngq	402	52	causing	cause	VBG
cord-018572-e2qq4ngq	402	53	retinal	retinal	JJ
cord-018572-e2qq4ngq	402	54	disease	disease	NN
cord-018572-e2qq4ngq	402	55	,	,	,
cord-018572-e2qq4ngq	402	56	regulates	regulate	VBZ
cord-018572-e2qq4ngq	402	57	trafficking	trafficking	NN
cord-018572-e2qq4ngq	402	58	by	by	IN
cord-018572-e2qq4ngq	402	59	binding	bind	VBG
cord-018572-e2qq4ngq	402	60	to	to	IN
cord-018572-e2qq4ngq	402	61	ADP	ADP	NNP
cord-018572-e2qq4ngq	402	62	-	-	HYPH
cord-018572-e2qq4ngq	402	63	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	402	64	factor	factor	NN
cord-018572-e2qq4ngq	402	65	4	4	CD
cord-018572-e2qq4ngq	403	1	(	(	-LRB-
cord-018572-e2qq4ngq	403	2	ARF4	ARF4	NNP
cord-018572-e2qq4ngq	403	3	)	)	-RRB-
cord-018572-e2qq4ngq	404	1	Structural	structural	JJ
cord-018572-e2qq4ngq	404	2	basis	basis	NN
cord-018572-e2qq4ngq	404	3	and	and	CC
cord-018572-e2qq4ngq	404	4	mechanism	mechanism	NN
cord-018572-e2qq4ngq	404	5	of	of	IN
cord-018572-e2qq4ngq	404	6	autoregulation	autoregulation	NN
cord-018572-e2qq4ngq	404	7	in	in	IN
cord-018572-e2qq4ngq	404	8	3-phosphoinositide	3-phosphoinositide	CD
cord-018572-e2qq4ngq	404	9	-	-	HYPH
cord-018572-e2qq4ngq	404	10	dependent	dependent	JJ
cord-018572-e2qq4ngq	404	11	Grp1	Grp1	NNP
cord-018572-e2qq4ngq	404	12	family	family	NN
cord-018572-e2qq4ngq	404	13	Arf	Arf	NNP
cord-018572-e2qq4ngq	404	14	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	404	15	exchange	exchange	NN
cord-018572-e2qq4ngq	404	16	factors	factor	NNS
cord-018572-e2qq4ngq	404	17	ARF	ARF	NNP
cord-018572-e2qq4ngq	404	18	family	family	NN
cord-018572-e2qq4ngq	404	19	G	g	NN
cord-018572-e2qq4ngq	404	20	proteins	protein	NNS
cord-018572-e2qq4ngq	404	21	and	and	CC
cord-018572-e2qq4ngq	404	22	their	-PRON-	PRP$
cord-018572-e2qq4ngq	404	23	regulators	regulator	NNS
cord-018572-e2qq4ngq	404	24	:	:	:
cord-018572-e2qq4ngq	404	25	roles	role	NNS
cord-018572-e2qq4ngq	404	26	in	in	IN
cord-018572-e2qq4ngq	404	27	membrane	membrane	NN
cord-018572-e2qq4ngq	404	28	transport	transport	NN
cord-018572-e2qq4ngq	404	29	,	,	.
cord-018572-e2qq4ngq	405	1	development	development	NN
cord-018572-e2qq4ngq	405	2	and	and	CC
cord-018572-e2qq4ngq	405	3	disease	disease	NN
cord-018572-e2qq4ngq	405	4	ARF	arf	NN
cord-018572-e2qq4ngq	405	5	proteins	protein	NNS
cord-018572-e2qq4ngq	405	6	:	:	:
cord-018572-e2qq4ngq	405	7	roles	role	NNS
cord-018572-e2qq4ngq	405	8	in	in	IN
cord-018572-e2qq4ngq	405	9	membrane	membrane	NN
cord-018572-e2qq4ngq	405	10	traffic	traffic	NN
cord-018572-e2qq4ngq	405	11	and	and	CC
cord-018572-e2qq4ngq	405	12	beyond	beyond	IN
cord-018572-e2qq4ngq	405	13	Lipid	lipid	NN
cord-018572-e2qq4ngq	405	14	droplets	droplet	NNS
cord-018572-e2qq4ngq	405	15	in	in	IN
cord-018572-e2qq4ngq	405	16	lipogenesis	lipogenesis	NN
cord-018572-e2qq4ngq	405	17	and	and	CC
cord-018572-e2qq4ngq	405	18	lipolysis	lipolysis	NN
cord-018572-e2qq4ngq	405	19	Differential	Differential	NNP
cord-018572-e2qq4ngq	405	20	membrane	membrane	NN
cord-018572-e2qq4ngq	405	21	association	association	NN
cord-018572-e2qq4ngq	405	22	properties	property	NNS
cord-018572-e2qq4ngq	405	23	and	and	CC
cord-018572-e2qq4ngq	405	24	regulation	regulation	NN
cord-018572-e2qq4ngq	405	25	of	of	IN
cord-018572-e2qq4ngq	405	26	class	class	NN
cord-018572-e2qq4ngq	405	27	I	i	NN
cord-018572-e2qq4ngq	405	28	and	and	CC
cord-018572-e2qq4ngq	405	29	class	class	NN
cord-018572-e2qq4ngq	405	30	II	ii	NN
cord-018572-e2qq4ngq	406	1	Arfs	Arfs	NNP
cord-018572-e2qq4ngq	406	2	Spermatocyte	Spermatocyte	NNP
cord-018572-e2qq4ngq	406	3	cytokinesis	cytokinesis	NN
cord-018572-e2qq4ngq	406	4	requires	require	VBZ
cord-018572-e2qq4ngq	406	5	rapid	rapid	JJ
cord-018572-e2qq4ngq	406	6	membrane	membrane	NN
cord-018572-e2qq4ngq	406	7	addition	addition	NN
cord-018572-e2qq4ngq	406	8	mediated	mediate	VBN
cord-018572-e2qq4ngq	406	9	by	by	IN
cord-018572-e2qq4ngq	406	10	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	406	11	on	on	IN
cord-018572-e2qq4ngq	406	12	central	central	JJ
cord-018572-e2qq4ngq	406	13	spindle	spindle	NN
cord-018572-e2qq4ngq	406	14	recycling	recycling	NN
cord-018572-e2qq4ngq	406	15	endosomes	endosome	VBZ
cord-018572-e2qq4ngq	406	16	Interaction	Interaction	NNP
cord-018572-e2qq4ngq	406	17	between	between	IN
cord-018572-e2qq4ngq	406	18	the	the	DT
cord-018572-e2qq4ngq	406	19	triglyceride	triglyceride	NN
cord-018572-e2qq4ngq	406	20	lipase	lipase	NN
cord-018572-e2qq4ngq	406	21	ATGL	ATGL	NNP
cord-018572-e2qq4ngq	406	22	and	and	CC
cord-018572-e2qq4ngq	406	23	the	the	DT
cord-018572-e2qq4ngq	406	24	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	406	25	activator	activator	NN
cord-018572-e2qq4ngq	406	26	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	406	27	TBC1D24	TBC1D24	NNP
cord-018572-e2qq4ngq	406	28	,	,	,
cord-018572-e2qq4ngq	406	29	an	an	DT
cord-018572-e2qq4ngq	406	30	ARF6-interacting	ARF6-interacting	NNP
cord-018572-e2qq4ngq	406	31	protein	protein	NN
cord-018572-e2qq4ngq	406	32	,	,	,
cord-018572-e2qq4ngq	406	33	is	be	VBZ
cord-018572-e2qq4ngq	406	34	mutated	mutate	VBN
cord-018572-e2qq4ngq	406	35	in	in	IN
cord-018572-e2qq4ngq	406	36	familial	familial	JJ
cord-018572-e2qq4ngq	406	37	infantile	infantile	JJ
cord-018572-e2qq4ngq	406	38	myoclonic	myoclonic	JJ
cord-018572-e2qq4ngq	406	39	epilepsy	epilepsy	NN
cord-018572-e2qq4ngq	406	40	Disruption	disruption	NN
cord-018572-e2qq4ngq	406	41	of	of	IN
cord-018572-e2qq4ngq	406	42	neural	neural	JJ
cord-018572-e2qq4ngq	406	43	progenitors	progenitor	NNS
cord-018572-e2qq4ngq	406	44	along	along	IN
cord-018572-e2qq4ngq	406	45	the	the	DT
cord-018572-e2qq4ngq	406	46	ventricular	ventricular	JJ
cord-018572-e2qq4ngq	406	47	and	and	CC
cord-018572-e2qq4ngq	406	48	subventricular	subventricular	JJ
cord-018572-e2qq4ngq	406	49	zones	zone	NNS
cord-018572-e2qq4ngq	406	50	in	in	IN
cord-018572-e2qq4ngq	406	51	periventricular	periventricular	NNP
cord-018572-e2qq4ngq	406	52	heterotopia	heterotopia	NNP
cord-018572-e2qq4ngq	407	1	A	a	DT
cord-018572-e2qq4ngq	407	2	novel	novel	JJ
cord-018572-e2qq4ngq	407	3	membrane	membrane	NN
cord-018572-e2qq4ngq	407	4	sensor	sensor	NN
cord-018572-e2qq4ngq	407	5	controls	control	VBZ
cord-018572-e2qq4ngq	407	6	the	the	DT
cord-018572-e2qq4ngq	407	7	localization	localization	NN
cord-018572-e2qq4ngq	407	8	and	and	CC
cord-018572-e2qq4ngq	407	9	ArfGEF	arfgef	JJ
cord-018572-e2qq4ngq	407	10	activity	activity	NN
cord-018572-e2qq4ngq	407	11	of	of	IN
cord-018572-e2qq4ngq	407	12	bacterial	bacterial	JJ
cord-018572-e2qq4ngq	407	13	RalF	RalF	NNP
cord-018572-e2qq4ngq	407	14	Myristoylation	Myristoylation	NNP
cord-018572-e2qq4ngq	407	15	of	of	IN
cord-018572-e2qq4ngq	407	16	ADP	ADP	NNP
cord-018572-e2qq4ngq	407	17	-	-	HYPH
cord-018572-e2qq4ngq	407	18	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	407	19	factor	factor	NN
cord-018572-e2qq4ngq	407	20	1	1	CD
cord-018572-e2qq4ngq	407	21	facilitates	facilitate	VBZ
cord-018572-e2qq4ngq	407	22	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	407	23	exchange	exchange	NN
cord-018572-e2qq4ngq	407	24	at	at	IN
cord-018572-e2qq4ngq	407	25	physiological	physiological	JJ
cord-018572-e2qq4ngq	407	26	Mg2	mg2	CD
cord-018572-e2qq4ngq	407	27	+	+	SYM
cord-018572-e2qq4ngq	407	28	levels	level	NNS
cord-018572-e2qq4ngq	407	29	EFA6	EFA6	NNP
cord-018572-e2qq4ngq	407	30	,	,	,
cord-018572-e2qq4ngq	407	31	a	a	DT
cord-018572-e2qq4ngq	407	32	sec7	sec7	NN
cord-018572-e2qq4ngq	407	33	domaincontaining	domaincontaine	VBG
cord-018572-e2qq4ngq	407	34	exchange	exchange	NN
cord-018572-e2qq4ngq	407	35	factor	factor	NN
cord-018572-e2qq4ngq	407	36	for	for	IN
cord-018572-e2qq4ngq	407	37	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	407	38	,	,	,
cord-018572-e2qq4ngq	407	39	coordinates	coordinate	VBZ
cord-018572-e2qq4ngq	407	40	membrane	membrane	NN
cord-018572-e2qq4ngq	407	41	recycling	recycling	NN
cord-018572-e2qq4ngq	407	42	and	and	CC
cord-018572-e2qq4ngq	407	43	actin	actin	NN
cord-018572-e2qq4ngq	407	44	cytoskeleton	cytoskeleton	NN
cord-018572-e2qq4ngq	407	45	organization	organization	NN
cord-018572-e2qq4ngq	407	46	Localization	Localization	NNP
cord-018572-e2qq4ngq	407	47	of	of	IN
cord-018572-e2qq4ngq	407	48	components	component	NNS
cord-018572-e2qq4ngq	407	49	involved	involve	VBN
cord-018572-e2qq4ngq	407	50	in	in	IN
cord-018572-e2qq4ngq	407	51	protein	protein	NN
cord-018572-e2qq4ngq	407	52	transport	transport	NN
cord-018572-e2qq4ngq	407	53	and	and	CC
cord-018572-e2qq4ngq	407	54	processing	process	VBG
cord-018572-e2qq4ngq	407	55	through	through	IN
cord-018572-e2qq4ngq	407	56	the	the	DT
cord-018572-e2qq4ngq	407	57	yeast	yeast	NN
cord-018572-e2qq4ngq	407	58	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	407	59	apparatus	apparatus	NN
cord-018572-e2qq4ngq	407	60	ADP	adp	NN
cord-018572-e2qq4ngq	407	61	-	-	HYPH
cord-018572-e2qq4ngq	407	62	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	407	63	factor	factor	NN
cord-018572-e2qq4ngq	407	64	arf6p	arf6p	RB
cord-018572-e2qq4ngq	407	65	may	may	MD
cord-018572-e2qq4ngq	407	66	function	function	VB
cord-018572-e2qq4ngq	407	67	as	as	IN
cord-018572-e2qq4ngq	407	68	a	a	DT
cord-018572-e2qq4ngq	407	69	molecular	molecular	JJ
cord-018572-e2qq4ngq	407	70	switch	switch	NN
cord-018572-e2qq4ngq	407	71	of	of	IN
cord-018572-e2qq4ngq	407	72	new	new	JJ
cord-018572-e2qq4ngq	407	73	end	end	NN
cord-018572-e2qq4ngq	407	74	take	take	VB
cord-018572-e2qq4ngq	407	75	off	off	RP
cord-018572-e2qq4ngq	407	76	in	in	IN
cord-018572-e2qq4ngq	407	77	fission	fission	NN
cord-018572-e2qq4ngq	407	78	yeast	yeast	NN
cord-018572-e2qq4ngq	408	1	DEF-1	DEF-1	NNP
cord-018572-e2qq4ngq	408	2	/	/	SYM
cord-018572-e2qq4ngq	408	3	ASAP1	ASAP1	NNP
cord-018572-e2qq4ngq	408	4	is	be	VBZ
cord-018572-e2qq4ngq	408	5	a	a	DT
cord-018572-e2qq4ngq	408	6	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	408	7	-	-	HYPH
cord-018572-e2qq4ngq	408	8	activating	activate	VBG
cord-018572-e2qq4ngq	408	9	protein	protein	NN
cord-018572-e2qq4ngq	408	10	(	(	-LRB-
cord-018572-e2qq4ngq	408	11	GAP	gap	NN
cord-018572-e2qq4ngq	408	12	)	)	-RRB-
cord-018572-e2qq4ngq	408	13	for	for	IN
cord-018572-e2qq4ngq	408	14	ARF1	ARF1	NNP
cord-018572-e2qq4ngq	408	15	that	that	WDT
cord-018572-e2qq4ngq	408	16	enhances	enhance	VBZ
cord-018572-e2qq4ngq	408	17	cell	cell	NN
cord-018572-e2qq4ngq	408	18	motility	motility	NN
cord-018572-e2qq4ngq	408	19	through	through	IN
cord-018572-e2qq4ngq	408	20	a	a	DT
cord-018572-e2qq4ngq	408	21	GAP	gap	NN
cord-018572-e2qq4ngq	408	22	-	-	HYPH
cord-018572-e2qq4ngq	408	23	dependent	dependent	JJ
cord-018572-e2qq4ngq	408	24	mechanism	mechanism	NN
cord-018572-e2qq4ngq	409	1	The	the	DT
cord-018572-e2qq4ngq	409	2	auxilin	auxilin	NN
cord-018572-e2qq4ngq	409	3	-	-	HYPH
cord-018572-e2qq4ngq	409	4	like	like	JJ
cord-018572-e2qq4ngq	409	5	phosphoprotein	phosphoprotein	NN
cord-018572-e2qq4ngq	409	6	Swa2p	Swa2p	NNP
cord-018572-e2qq4ngq	409	7	is	be	VBZ
cord-018572-e2qq4ngq	409	8	required	require	VBN
cord-018572-e2qq4ngq	409	9	for	for	IN
cord-018572-e2qq4ngq	409	10	clathrin	clathrin	NN
cord-018572-e2qq4ngq	409	11	function	function	NN
cord-018572-e2qq4ngq	409	12	in	in	IN
cord-018572-e2qq4ngq	409	13	yeast	yeast	NN
cord-018572-e2qq4ngq	409	14	Genes	Genes	NNPS
cord-018572-e2qq4ngq	409	15	encoding	encode	VBG
cord-018572-e2qq4ngq	409	16	ADP	adp	NN
cord-018572-e2qq4ngq	409	17	-	-	HYPH
cord-018572-e2qq4ngq	409	18	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	409	19	factors	factor	NNS
cord-018572-e2qq4ngq	409	20	in	in	IN
cord-018572-e2qq4ngq	409	21	Arabidopsis	Arabidopsis	NNP
cord-018572-e2qq4ngq	409	22	thaliana	thaliana	NN
cord-018572-e2qq4ngq	409	23	L.	L.	NNP
cord-018572-e2qq4ngq	409	24	Heyn	Heyn	NNP
cord-018572-e2qq4ngq	409	25	.	.	.
cord-018572-e2qq4ngq	410	1	;	;	:
cord-018572-e2qq4ngq	410	2	genome	genome	NN
cord-018572-e2qq4ngq	410	3	analysis	analysis	NN
cord-018572-e2qq4ngq	410	4	and	and	CC
cord-018572-e2qq4ngq	410	5	antisense	antisense	NN
cord-018572-e2qq4ngq	410	6	suppression	suppression	NN
cord-018572-e2qq4ngq	410	7	Identification	Identification	NNP
cord-018572-e2qq4ngq	410	8	of	of	IN
cord-018572-e2qq4ngq	410	9	a	a	DT
cord-018572-e2qq4ngq	410	10	guanine	guanine	NN
cord-018572-e2qq4ngq	410	11	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	410	12	exchange	exchange	NN
cord-018572-e2qq4ngq	410	13	factor	factor	NN
cord-018572-e2qq4ngq	410	14	for	for	IN
cord-018572-e2qq4ngq	410	15	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	410	16	,	,	,
cord-018572-e2qq4ngq	410	17	the	the	DT
cord-018572-e2qq4ngq	410	18	yeast	yeast	NN
cord-018572-e2qq4ngq	410	19	orthologue	orthologue	NN
cord-018572-e2qq4ngq	410	20	of	of	IN
cord-018572-e2qq4ngq	410	21	mammalian	mammalian	JJ
cord-018572-e2qq4ngq	410	22	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	411	1	The	the	DT
cord-018572-e2qq4ngq	411	2	small	small	JJ
cord-018572-e2qq4ngq	411	3	G	g	NN
cord-018572-e2qq4ngq	411	4	proteins	protein	NNS
cord-018572-e2qq4ngq	411	5	of	of	IN
cord-018572-e2qq4ngq	411	6	the	the	DT
cord-018572-e2qq4ngq	411	7	Arf	Arf	NNP
cord-018572-e2qq4ngq	411	8	family	family	NN
cord-018572-e2qq4ngq	411	9	and	and	CC
cord-018572-e2qq4ngq	411	10	their	-PRON-	PRP$
cord-018572-e2qq4ngq	411	11	regulators	regulator	NNS
cord-018572-e2qq4ngq	411	12	Structural	structural	JJ
cord-018572-e2qq4ngq	411	13	basis	basis	NN
cord-018572-e2qq4ngq	411	14	for	for	IN
cord-018572-e2qq4ngq	411	15	activation	activation	NN
cord-018572-e2qq4ngq	411	16	of	of	IN
cord-018572-e2qq4ngq	411	17	ARF	ARF	NNP
cord-018572-e2qq4ngq	411	18	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	411	19	:	:	:
cord-018572-e2qq4ngq	411	20	mechanisms	mechanism	NNS
cord-018572-e2qq4ngq	411	21	of	of	IN
cord-018572-e2qq4ngq	411	22	guanine	guanine	NN
cord-018572-e2qq4ngq	411	23	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	411	24	exchange	exchange	NN
cord-018572-e2qq4ngq	411	25	and	and	CC
cord-018572-e2qq4ngq	411	26	GTP	GTP	NNP
cord-018572-e2qq4ngq	411	27	-	-	HYPH
cord-018572-e2qq4ngq	411	28	myristoyl	myristoyl	NNP
cord-018572-e2qq4ngq	411	29	switching	switch	VBG
cord-018572-e2qq4ngq	411	30	Modulation	modulation	NN
cord-018572-e2qq4ngq	411	31	of	of	IN
cord-018572-e2qq4ngq	411	32	small	small	JJ
cord-018572-e2qq4ngq	411	33	GTPases	gtpase	NNS
cord-018572-e2qq4ngq	411	34	by	by	IN
cord-018572-e2qq4ngq	411	35	legionella	legionella	NN
cord-018572-e2qq4ngq	411	36	Identification	identification	NN
cord-018572-e2qq4ngq	411	37	of	of	IN
cord-018572-e2qq4ngq	411	38	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	411	39	as	as	IN
cord-018572-e2qq4ngq	411	40	a	a	DT
cord-018572-e2qq4ngq	411	41	cellular	cellular	JJ
cord-018572-e2qq4ngq	411	42	factor	factor	NN
cord-018572-e2qq4ngq	411	43	required	require	VBN
cord-018572-e2qq4ngq	411	44	for	for	IN
cord-018572-e2qq4ngq	411	45	hepatitis	hepatitis	NNP
cord-018572-e2qq4ngq	411	46	C	C	NNP
cord-018572-e2qq4ngq	411	47	virus	virus	NN
cord-018572-e2qq4ngq	411	48	RNA	RNA	NNP
cord-018572-e2qq4ngq	411	49	replication	replication	NN
cord-018572-e2qq4ngq	411	50	Pathways	pathway	NNS
cord-018572-e2qq4ngq	411	51	and	and	CC
cord-018572-e2qq4ngq	411	52	mechanisms	mechanism	NNS
cord-018572-e2qq4ngq	411	53	of	of	IN
cord-018572-e2qq4ngq	411	54	endocytic	endocytic	JJ
cord-018572-e2qq4ngq	411	55	recycling	recycle	VBG
cord-018572-e2qq4ngq	411	56	Functional	functional	JJ
cord-018572-e2qq4ngq	411	57	genomic	genomic	JJ
cord-018572-e2qq4ngq	411	58	screen	screen	NN
cord-018572-e2qq4ngq	411	59	reveals	reveal	VBZ
cord-018572-e2qq4ngq	411	60	genes	gene	NNS
cord-018572-e2qq4ngq	411	61	involved	involve	VBN
cord-018572-e2qq4ngq	411	62	in	in	IN
cord-018572-e2qq4ngq	411	63	lipid	lipid	NN
cord-018572-e2qq4ngq	411	64	-	-	HYPH
cord-018572-e2qq4ngq	411	65	droplet	droplet	NN
cord-018572-e2qq4ngq	411	66	formation	formation	NN
cord-018572-e2qq4ngq	411	67	and	and	CC
cord-018572-e2qq4ngq	411	68	utilization	utilization	NN
cord-018572-e2qq4ngq	411	69	Analysis	Analysis	NNP
cord-018572-e2qq4ngq	411	70	of	of	IN
cord-018572-e2qq4ngq	411	71	GTPaseactivating	gtpaseactivate	VBG
cord-018572-e2qq4ngq	411	72	proteins	protein	NNS
cord-018572-e2qq4ngq	411	73	:	:	:
cord-018572-e2qq4ngq	412	1	Rab1	Rab1	NNP
cord-018572-e2qq4ngq	412	2	and	and	CC
cord-018572-e2qq4ngq	412	3	Rab43	Rab43	NNP
cord-018572-e2qq4ngq	412	4	are	be	VBP
cord-018572-e2qq4ngq	412	5	key	key	JJ
cord-018572-e2qq4ngq	412	6	Rabs	Rabs	NNPS
cord-018572-e2qq4ngq	412	7	required	require	VBD
cord-018572-e2qq4ngq	412	8	to	to	TO
cord-018572-e2qq4ngq	412	9	maintain	maintain	VB
cord-018572-e2qq4ngq	412	10	a	a	DT
cord-018572-e2qq4ngq	412	11	functional	functional	JJ
cord-018572-e2qq4ngq	412	12	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	412	13	complex	complex	NN
cord-018572-e2qq4ngq	412	14	in	in	IN
cord-018572-e2qq4ngq	412	15	human	human	JJ
cord-018572-e2qq4ngq	412	16	cells	cell	NNS
cord-018572-e2qq4ngq	413	1	The	the	DT
cord-018572-e2qq4ngq	413	2	Arl4	Arl4	NNP
cord-018572-e2qq4ngq	413	3	family	family	NN
cord-018572-e2qq4ngq	413	4	of	of	IN
cord-018572-e2qq4ngq	413	5	small	small	JJ
cord-018572-e2qq4ngq	413	6	G	g	NN
cord-018572-e2qq4ngq	413	7	proteins	protein	NNS
cord-018572-e2qq4ngq	413	8	can	can	MD
cord-018572-e2qq4ngq	413	9	recruit	recruit	VB
cord-018572-e2qq4ngq	413	10	the	the	DT
cord-018572-e2qq4ngq	413	11	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	413	12	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	413	13	exchange	exchange	NN
cord-018572-e2qq4ngq	413	14	factors	factor	NNS
cord-018572-e2qq4ngq	413	15	to	to	IN
cord-018572-e2qq4ngq	413	16	the	the	DT
cord-018572-e2qq4ngq	413	17	plasma	plasma	NN
cord-018572-e2qq4ngq	413	18	membrane	membrane	NN
cord-018572-e2qq4ngq	414	1	Phosphatidylinositol	Phosphatidylinositol	NNP
cord-018572-e2qq4ngq	414	2	4-phosphate	4-phosphate	CD
cord-018572-e2qq4ngq	414	3	5-kinase	5-kinase	CD
cord-018572-e2qq4ngq	414	4	alpha	alpha	NN
cord-018572-e2qq4ngq	414	5	is	be	VBZ
cord-018572-e2qq4ngq	414	6	a	a	DT
cord-018572-e2qq4ngq	414	7	downstream	downstream	JJ
cord-018572-e2qq4ngq	414	8	effector	effector	NN
cord-018572-e2qq4ngq	414	9	of	of	IN
cord-018572-e2qq4ngq	414	10	the	the	DT
cord-018572-e2qq4ngq	414	11	small	small	JJ
cord-018572-e2qq4ngq	414	12	G	g	NN
cord-018572-e2qq4ngq	414	13	protein	protein	NN
cord-018572-e2qq4ngq	414	14	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	414	15	in	in	IN
cord-018572-e2qq4ngq	414	16	membrane	membrane	NN
cord-018572-e2qq4ngq	414	17	ruffle	ruffle	NN
cord-018572-e2qq4ngq	414	18	formation	formation	NN
cord-018572-e2qq4ngq	414	19	Targeting	target	VBG
cord-018572-e2qq4ngq	414	20	of	of	IN
cord-018572-e2qq4ngq	415	1	Arf-1	Arf-1	NNP
cord-018572-e2qq4ngq	415	2	to	to	IN
cord-018572-e2qq4ngq	415	3	the	the	DT
cord-018572-e2qq4ngq	415	4	early	early	JJ
cord-018572-e2qq4ngq	415	5	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	415	6	by	by	IN
cord-018572-e2qq4ngq	415	7	membrin	membrin	NNP
cord-018572-e2qq4ngq	415	8	,	,	,
cord-018572-e2qq4ngq	415	9	an	an	DT
cord-018572-e2qq4ngq	415	10	ER	ER	NNP
cord-018572-e2qq4ngq	415	11	-	-	HYPH
cord-018572-e2qq4ngq	415	12	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	415	13	SNARE	SNARE	NNP
cord-018572-e2qq4ngq	415	14	Phospholipid	phospholipid	NN
cord-018572-e2qq4ngq	415	15	-	-	:
cord-018572-e2qq4ngq	415	16	and	and	CC
cord-018572-e2qq4ngq	415	17	GTP	gtp	NN
cord-018572-e2qq4ngq	415	18	-	-	HYPH
cord-018572-e2qq4ngq	415	19	dependent	dependent	JJ
cord-018572-e2qq4ngq	415	20	activation	activation	NN
cord-018572-e2qq4ngq	415	21	of	of	IN
cord-018572-e2qq4ngq	415	22	cholera	cholera	NN
cord-018572-e2qq4ngq	415	23	toxin	toxin	NN
cord-018572-e2qq4ngq	415	24	and	and	CC
cord-018572-e2qq4ngq	415	25	phospholipase	phospholipase	NN
cord-018572-e2qq4ngq	415	26	D	d	NN
cord-018572-e2qq4ngq	415	27	by	by	IN
cord-018572-e2qq4ngq	415	28	human	human	JJ
cord-018572-e2qq4ngq	415	29	ADP	adp	NN
cord-018572-e2qq4ngq	415	30	-	-	HYPH
cord-018572-e2qq4ngq	415	31	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	415	32	factor	factor	NN
cord-018572-e2qq4ngq	415	33	-	-	HYPH
cord-018572-e2qq4ngq	415	34	like	like	JJ
cord-018572-e2qq4ngq	415	35	protein	protein	NN
cord-018572-e2qq4ngq	415	36	1	1	CD
cord-018572-e2qq4ngq	416	1	(	(	-LRB-
cord-018572-e2qq4ngq	416	2	HARL1	HARL1	NNP
cord-018572-e2qq4ngq	416	3	)	)	-RRB-
cord-018572-e2qq4ngq	417	1	Viral	viral	JJ
cord-018572-e2qq4ngq	417	2	reorganization	reorganization	NN
cord-018572-e2qq4ngq	417	3	of	of	IN
cord-018572-e2qq4ngq	417	4	the	the	DT
cord-018572-e2qq4ngq	417	5	secretory	secretory	JJ
cord-018572-e2qq4ngq	417	6	pathway	pathway	NN
cord-018572-e2qq4ngq	417	7	generates	generate	VBZ
cord-018572-e2qq4ngq	417	8	distinct	distinct	JJ
cord-018572-e2qq4ngq	417	9	organelles	organelle	NNS
cord-018572-e2qq4ngq	417	10	for	for	IN
cord-018572-e2qq4ngq	417	11	RNA	rna	NN
cord-018572-e2qq4ngq	417	12	replication	replication	NN
cord-018572-e2qq4ngq	417	13	Role	role	NN
cord-018572-e2qq4ngq	417	14	for	for	IN
cord-018572-e2qq4ngq	417	15	Arf3p	Arf3p	NNP
cord-018572-e2qq4ngq	417	16	in	in	IN
cord-018572-e2qq4ngq	417	17	development	development	NN
cord-018572-e2qq4ngq	417	18	of	of	IN
cord-018572-e2qq4ngq	417	19	polarity	polarity	NN
cord-018572-e2qq4ngq	417	20	,	,	,
cord-018572-e2qq4ngq	417	21	but	but	CC
cord-018572-e2qq4ngq	417	22	not	not	RB
cord-018572-e2qq4ngq	417	23	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	417	24	,	,	,
cord-018572-e2qq4ngq	417	25	in	in	IN
cord-018572-e2qq4ngq	417	26	Saccharomyces	Saccharomyces	NNP
cord-018572-e2qq4ngq	417	27	cerevisiae	cerevisiae	NNS
cord-018572-e2qq4ngq	417	28	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	417	29	coordinates	coordinate	VBZ
cord-018572-e2qq4ngq	417	30	actin	actin	NN
cord-018572-e2qq4ngq	417	31	assembly	assembly	NN
cord-018572-e2qq4ngq	417	32	through	through	IN
cord-018572-e2qq4ngq	417	33	the	the	DT
cord-018572-e2qq4ngq	417	34	WAVE	WAVE	NNP
cord-018572-e2qq4ngq	417	35	complex	complex	NN
cord-018572-e2qq4ngq	417	36	,	,	,
cord-018572-e2qq4ngq	417	37	a	a	DT
cord-018572-e2qq4ngq	417	38	mechanism	mechanism	NN
cord-018572-e2qq4ngq	417	39	usurped	usurp	VBN
cord-018572-e2qq4ngq	417	40	by	by	IN
cord-018572-e2qq4ngq	417	41	Salmonella	Salmonella	NNP
cord-018572-e2qq4ngq	417	42	to	to	TO
cord-018572-e2qq4ngq	417	43	invade	invade	VB
cord-018572-e2qq4ngq	417	44	host	host	NN
cord-018572-e2qq4ngq	417	45	cells	cell	NNS
cord-018572-e2qq4ngq	418	1	Enteroviruses	Enteroviruses	NNP
cord-018572-e2qq4ngq	418	2	harness	harness	VBP
cord-018572-e2qq4ngq	418	3	the	the	DT
cord-018572-e2qq4ngq	418	4	cellular	cellular	JJ
cord-018572-e2qq4ngq	418	5	endocytic	endocytic	JJ
cord-018572-e2qq4ngq	418	6	machinery	machinery	NN
cord-018572-e2qq4ngq	418	7	to	to	TO
cord-018572-e2qq4ngq	418	8	remodel	remodel	VB
cord-018572-e2qq4ngq	418	9	the	the	DT
cord-018572-e2qq4ngq	418	10	host	host	NN
cord-018572-e2qq4ngq	418	11	cell	cell	NN
cord-018572-e2qq4ngq	418	12	cholesterol	cholesterol	NN
cord-018572-e2qq4ngq	418	13	landscape	landscape	NN
cord-018572-e2qq4ngq	418	14	for	for	IN
cord-018572-e2qq4ngq	418	15	effective	effective	JJ
cord-018572-e2qq4ngq	418	16	viral	viral	JJ
cord-018572-e2qq4ngq	418	17	replication	replication	NN
cord-018572-e2qq4ngq	418	18	Arf	Arf	NNP
cord-018572-e2qq4ngq	418	19	GAPs	gaps	NN
cord-018572-e2qq4ngq	418	20	and	and	CC
cord-018572-e2qq4ngq	418	21	their	-PRON-	PRP$
cord-018572-e2qq4ngq	418	22	interacting	interact	VBG
cord-018572-e2qq4ngq	418	23	proteins	protein	NNS
cord-018572-e2qq4ngq	419	1	The	the	DT
cord-018572-e2qq4ngq	419	2	structural	structural	JJ
cord-018572-e2qq4ngq	419	3	basis	basis	NN
cord-018572-e2qq4ngq	419	4	of	of	IN
cord-018572-e2qq4ngq	419	5	Arf	Arf	NNP
cord-018572-e2qq4ngq	419	6	effector	effector	NN
cord-018572-e2qq4ngq	419	7	specificity	specificity	NN
cord-018572-e2qq4ngq	419	8	:	:	:
cord-018572-e2qq4ngq	419	9	the	the	DT
cord-018572-e2qq4ngq	419	10	crystal	crystal	NN
cord-018572-e2qq4ngq	419	11	structure	structure	NN
cord-018572-e2qq4ngq	419	12	of	of	IN
cord-018572-e2qq4ngq	419	13	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	419	14	in	in	IN
cord-018572-e2qq4ngq	419	15	a	a	DT
cord-018572-e2qq4ngq	419	16	complex	complex	NN
cord-018572-e2qq4ngq	419	17	with	with	IN
cord-018572-e2qq4ngq	419	18	JIP4	JIP4	NNP
cord-018572-e2qq4ngq	419	19	Redundant	redundant	JJ
cord-018572-e2qq4ngq	419	20	roles	role	NNS
cord-018572-e2qq4ngq	419	21	of	of	IN
cord-018572-e2qq4ngq	419	22	BIG2	BIG2	NNP
cord-018572-e2qq4ngq	419	23	and	and	CC
cord-018572-e2qq4ngq	419	24	BIG1	BIG1	NNP
cord-018572-e2qq4ngq	419	25	,	,	,
cord-018572-e2qq4ngq	419	26	guanine	guanine	NN
cord-018572-e2qq4ngq	419	27	-	-	HYPH
cord-018572-e2qq4ngq	419	28	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	419	29	exchange	exchange	NN
cord-018572-e2qq4ngq	419	30	factors	factor	NNS
cord-018572-e2qq4ngq	419	31	for	for	IN
cord-018572-e2qq4ngq	419	32	ADP	adp	NN
cord-018572-e2qq4ngq	419	33	-	-	HYPH
cord-018572-e2qq4ngq	419	34	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	419	35	factors	factor	NNS
cord-018572-e2qq4ngq	419	36	in	in	IN
cord-018572-e2qq4ngq	419	37	membrane	membrane	NN
cord-018572-e2qq4ngq	419	38	traffic	traffic	NN
cord-018572-e2qq4ngq	419	39	between	between	IN
cord-018572-e2qq4ngq	419	40	the	the	DT
cord-018572-e2qq4ngq	419	41	trans	trans	NNP
cord-018572-e2qq4ngq	419	42	-	-	NNP
cord-018572-e2qq4ngq	419	43	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	419	44	network	network	NN
cord-018572-e2qq4ngq	419	45	and	and	CC
cord-018572-e2qq4ngq	419	46	endosomes	endosome	NNS
cord-018572-e2qq4ngq	420	1	A	a	DT
cord-018572-e2qq4ngq	420	2	large	large	JJ
cord-018572-e2qq4ngq	420	3	-	-	HYPH
cord-018572-e2qq4ngq	420	4	scale	scale	NN
cord-018572-e2qq4ngq	420	5	conformational	conformational	JJ
cord-018572-e2qq4ngq	420	6	change	change	NN
cord-018572-e2qq4ngq	420	7	couples	couple	NNS
cord-018572-e2qq4ngq	420	8	membrane	membrane	NN
cord-018572-e2qq4ngq	420	9	recruitment	recruitment	NN
cord-018572-e2qq4ngq	420	10	to	to	TO
cord-018572-e2qq4ngq	420	11	cargo	cargo	VB
cord-018572-e2qq4ngq	420	12	binding	bind	VBG
cord-018572-e2qq4ngq	420	13	in	in	IN
cord-018572-e2qq4ngq	420	14	the	the	DT
cord-018572-e2qq4ngq	420	15	AP2	AP2	NNP
cord-018572-e2qq4ngq	420	16	clathrin	clathrin	NN
cord-018572-e2qq4ngq	420	17	adaptor	adaptor	NN
cord-018572-e2qq4ngq	420	18	complex	complex	JJ
cord-018572-e2qq4ngq	421	1	The	the	DT
cord-018572-e2qq4ngq	421	2	protein	protein	NN
cord-018572-e2qq4ngq	421	3	cofactor	cofactor	NN
cord-018572-e2qq4ngq	421	4	necessary	necessary	JJ
cord-018572-e2qq4ngq	421	5	for	for	IN
cord-018572-e2qq4ngq	421	6	ADP	adp	NN
cord-018572-e2qq4ngq	421	7	-	-	HYPH
cord-018572-e2qq4ngq	421	8	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	421	9	of	of	IN
cord-018572-e2qq4ngq	421	10	Gs	Gs	NNP
cord-018572-e2qq4ngq	421	11	by	by	IN
cord-018572-e2qq4ngq	421	12	cholera	cholera	NN
cord-018572-e2qq4ngq	421	13	toxin	toxin	NN
cord-018572-e2qq4ngq	421	14	is	be	VBZ
cord-018572-e2qq4ngq	421	15	itself	-PRON-	PRP
cord-018572-e2qq4ngq	421	16	a	a	DT
cord-018572-e2qq4ngq	421	17	GTP	gtp	NN
cord-018572-e2qq4ngq	421	18	binding	bind	VBG
cord-018572-e2qq4ngq	421	19	protein	protein	NN
cord-018572-e2qq4ngq	421	20	Mutational	Mutational	NNP
cord-018572-e2qq4ngq	421	21	analysis	analysis	NN
cord-018572-e2qq4ngq	421	22	of	of	IN
cord-018572-e2qq4ngq	421	23	Saccharomyces	Saccharomyces	NNP
cord-018572-e2qq4ngq	421	24	cerevisiae	cerevisiae	VBZ
cord-018572-e2qq4ngq	421	25	ARF1	ARF1	NNP
cord-018572-e2qq4ngq	421	26	Structural	structural	JJ
cord-018572-e2qq4ngq	421	27	biology	biology	NN
cord-018572-e2qq4ngq	421	28	of	of	IN
cord-018572-e2qq4ngq	421	29	Arf	Arf	NNP
cord-018572-e2qq4ngq	421	30	and	and	CC
cord-018572-e2qq4ngq	421	31	Rab	Rab	NNP
cord-018572-e2qq4ngq	421	32	GTPases	GTPases	NNP
cord-018572-e2qq4ngq	421	33	'	'	''
cord-018572-e2qq4ngq	422	1	effector	effector	JJ
cord-018572-e2qq4ngq	422	2	recruitment	recruitment	NN
cord-018572-e2qq4ngq	422	3	and	and	CC
cord-018572-e2qq4ngq	422	4	specificity	specificity	NN
cord-018572-e2qq4ngq	422	5	Brefeldin	Brefeldin	NNP
cord-018572-e2qq4ngq	422	6	A	A	NNP
cord-018572-e2qq4ngq	422	7	:	:	:
cord-018572-e2qq4ngq	422	8	insights	insight	NNS
cord-018572-e2qq4ngq	422	9	into	into	IN
cord-018572-e2qq4ngq	422	10	the	the	DT
cord-018572-e2qq4ngq	422	11	control	control	NN
cord-018572-e2qq4ngq	422	12	of	of	IN
cord-018572-e2qq4ngq	422	13	membrane	membrane	NN
cord-018572-e2qq4ngq	422	14	traffic	traffic	NN
cord-018572-e2qq4ngq	422	15	and	and	CC
cord-018572-e2qq4ngq	422	16	organelle	organelle	NN
cord-018572-e2qq4ngq	422	17	structure	structure	NN
cord-018572-e2qq4ngq	423	1	Discrete	discrete	JJ
cord-018572-e2qq4ngq	423	2	determinants	determinant	NNS
cord-018572-e2qq4ngq	423	3	in	in	IN
cord-018572-e2qq4ngq	423	4	ArfGAP2/3	arfgap2/3	DT
cord-018572-e2qq4ngq	423	5	conferring	confer	VBG
cord-018572-e2qq4ngq	423	6	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	423	7	localization	localization	NN
cord-018572-e2qq4ngq	423	8	and	and	CC
cord-018572-e2qq4ngq	423	9	regulation	regulation	NN
cord-018572-e2qq4ngq	423	10	by	by	IN
cord-018572-e2qq4ngq	423	11	the	the	DT
cord-018572-e2qq4ngq	423	12	COPI	COPI	NNP
cord-018572-e2qq4ngq	423	13	coat	coat	NN
cord-018572-e2qq4ngq	423	14	Guanine	guanine	NN
cord-018572-e2qq4ngq	423	15	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	423	16	exchange	exchange	NN
cord-018572-e2qq4ngq	423	17	factors	factor	NNS
cord-018572-e2qq4ngq	423	18	of	of	IN
cord-018572-e2qq4ngq	423	19	the	the	DT
cord-018572-e2qq4ngq	423	20	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	423	21	family	family	NN
cord-018572-e2qq4ngq	423	22	and	and	CC
cord-018572-e2qq4ngq	423	23	their	-PRON-	PRP$
cord-018572-e2qq4ngq	423	24	roles	role	NNS
cord-018572-e2qq4ngq	423	25	in	in	IN
cord-018572-e2qq4ngq	423	26	signal	signal	NN
cord-018572-e2qq4ngq	423	27	transduction	transduction	NN
cord-018572-e2qq4ngq	423	28	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	423	29	recruits	recruit	VBZ
cord-018572-e2qq4ngq	423	30	the	the	DT
cord-018572-e2qq4ngq	423	31	Rac	Rac	NNP
cord-018572-e2qq4ngq	423	32	GEF	GEF	NNP
cord-018572-e2qq4ngq	423	33	Kalirin	Kalirin	NNP
cord-018572-e2qq4ngq	423	34	to	to	IN
cord-018572-e2qq4ngq	423	35	the	the	DT
cord-018572-e2qq4ngq	423	36	plasma	plasma	NN
cord-018572-e2qq4ngq	423	37	membrane	membrane	NN
cord-018572-e2qq4ngq	423	38	facilitating	facilitate	VBG
cord-018572-e2qq4ngq	423	39	Rac	Rac	NNP
cord-018572-e2qq4ngq	423	40	activation	activation	NN
cord-018572-e2qq4ngq	423	41	Molecular	molecular	JJ
cord-018572-e2qq4ngq	423	42	paleontology	paleontology	NN
cord-018572-e2qq4ngq	423	43	and	and	CC
cord-018572-e2qq4ngq	423	44	complexity	complexity	NN
cord-018572-e2qq4ngq	423	45	in	in	IN
cord-018572-e2qq4ngq	423	46	the	the	DT
cord-018572-e2qq4ngq	423	47	last	last	JJ
cord-018572-e2qq4ngq	423	48	eukaryotic	eukaryotic	JJ
cord-018572-e2qq4ngq	423	49	common	common	JJ
cord-018572-e2qq4ngq	423	50	ancestor	ancestor	NN
cord-018572-e2qq4ngq	423	51	The	the	DT
cord-018572-e2qq4ngq	423	52	tyrosine	tyrosine	NN
cord-018572-e2qq4ngq	423	53	kinase	kinase	NN
cord-018572-e2qq4ngq	423	54	Pyk2	Pyk2	NNP
cord-018572-e2qq4ngq	423	55	regulates	regulate	VBZ
cord-018572-e2qq4ngq	423	56	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	423	57	activity	activity	NN
cord-018572-e2qq4ngq	423	58	by	by	IN
cord-018572-e2qq4ngq	423	59	phosphorylation	phosphorylation	NN
cord-018572-e2qq4ngq	423	60	and	and	CC
cord-018572-e2qq4ngq	423	61	inhibition	inhibition	NN
cord-018572-e2qq4ngq	423	62	of	of	IN
cord-018572-e2qq4ngq	423	63	the	the	DT
cord-018572-e2qq4ngq	423	64	Arf	Arf	NNP
cord-018572-e2qq4ngq	423	65	-	-	HYPH
cord-018572-e2qq4ngq	423	66	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	423	67	-	-	HYPH
cord-018572-e2qq4ngq	423	68	activating	activate	VBG
cord-018572-e2qq4ngq	423	69	protein	protein	NN
cord-018572-e2qq4ngq	423	70	ASAP1	ASAP1	NNP
cord-018572-e2qq4ngq	423	71	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	423	72	,	,	,
cord-018572-e2qq4ngq	423	73	a	a	DT
cord-018572-e2qq4ngq	423	74	guanine	guanine	NN
cord-018572-e2qq4ngq	423	75	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	423	76	exchange	exchange	NN
cord-018572-e2qq4ngq	423	77	factor	factor	NN
cord-018572-e2qq4ngq	423	78	for	for	IN
cord-018572-e2qq4ngq	423	79	Arf	Arf	NNP
cord-018572-e2qq4ngq	423	80	,	,	,
cord-018572-e2qq4ngq	423	81	is	be	VBZ
cord-018572-e2qq4ngq	423	82	crucial	crucial	JJ
cord-018572-e2qq4ngq	423	83	for	for	IN
cord-018572-e2qq4ngq	423	84	coxsackievirus	coxsackievirus	NNP
cord-018572-e2qq4ngq	423	85	B3	B3	NNP
cord-018572-e2qq4ngq	423	86	RNA	RNA	NNP
cord-018572-e2qq4ngq	423	87	replication	replication	NN
cord-018572-e2qq4ngq	423	88	Bi	Bi	NNP
cord-018572-e2qq4ngq	423	89	-	-	HYPH
cord-018572-e2qq4ngq	423	90	directional	directional	JJ
cord-018572-e2qq4ngq	423	91	protein	protein	NN
cord-018572-e2qq4ngq	423	92	transport	transport	NN
cord-018572-e2qq4ngq	423	93	between	between	IN
cord-018572-e2qq4ngq	423	94	the	the	DT
cord-018572-e2qq4ngq	423	95	ER	ER	NNP
cord-018572-e2qq4ngq	423	96	and	and	CC
cord-018572-e2qq4ngq	423	97	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	423	98	Aspergillus	Aspergillus	NNP
cord-018572-e2qq4ngq	423	99	nidulans	nidulan	NNS
cord-018572-e2qq4ngq	424	1	ArfB	ArfB	NNP
cord-018572-e2qq4ngq	424	2	plays	play	VBZ
cord-018572-e2qq4ngq	424	3	a	a	DT
cord-018572-e2qq4ngq	424	4	role	role	NN
cord-018572-e2qq4ngq	424	5	in	in	IN
cord-018572-e2qq4ngq	424	6	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	424	7	and	and	CC
cord-018572-e2qq4ngq	424	8	polarized	polarized	JJ
cord-018572-e2qq4ngq	424	9	growth	growth	NN
cord-018572-e2qq4ngq	424	10	Non	non	JJ
cord-018572-e2qq4ngq	424	11	-	-	JJ
cord-018572-e2qq4ngq	424	12	vesicular	vesicular	JJ
cord-018572-e2qq4ngq	424	13	lipid	lipid	NN
cord-018572-e2qq4ngq	424	14	transport	transport	NN
cord-018572-e2qq4ngq	424	15	by	by	IN
cord-018572-e2qq4ngq	424	16	lipid	lipid	NN
cord-018572-e2qq4ngq	424	17	-	-	HYPH
cord-018572-e2qq4ngq	424	18	transfer	transfer	NN
cord-018572-e2qq4ngq	424	19	proteins	protein	NNS
cord-018572-e2qq4ngq	424	20	and	and	CC
cord-018572-e2qq4ngq	424	21	beyond	beyond	IN
cord-018572-e2qq4ngq	424	22	Inter	Inter	NNP
cord-018572-e2qq4ngq	424	23	-	-	NN
cord-018572-e2qq4ngq	424	24	organelle	organelle	NN
cord-018572-e2qq4ngq	424	25	membrane	membrane	NN
cord-018572-e2qq4ngq	424	26	contact	contact	NN
cord-018572-e2qq4ngq	424	27	sites	site	NNS
cord-018572-e2qq4ngq	424	28	:	:	:
cord-018572-e2qq4ngq	425	1	through	through	IN
cord-018572-e2qq4ngq	425	2	a	a	DT
cord-018572-e2qq4ngq	425	3	glass	glass	NN
cord-018572-e2qq4ngq	425	4	,	,	,
cord-018572-e2qq4ngq	425	5	darkly	darkly	RB
cord-018572-e2qq4ngq	425	6	Endoplasmic	Endoplasmic	NNP
cord-018572-e2qq4ngq	425	7	reticulum	reticulum	NN
cord-018572-e2qq4ngq	425	8	:	:	:
cord-018572-e2qq4ngq	425	9	one	one	CD
cord-018572-e2qq4ngq	425	10	continuous	continuous	JJ
cord-018572-e2qq4ngq	425	11	network	network	NN
cord-018572-e2qq4ngq	425	12	compartmentalized	compartmentalize	VBN
cord-018572-e2qq4ngq	425	13	by	by	IN
cord-018572-e2qq4ngq	425	14	extrinsic	extrinsic	JJ
cord-018572-e2qq4ngq	425	15	cues	cue	NNS
cord-018572-e2qq4ngq	425	16	Functional	functional	JJ
cord-018572-e2qq4ngq	425	17	genomic	genomic	JJ
cord-018572-e2qq4ngq	425	18	analysis	analysis	NN
cord-018572-e2qq4ngq	425	19	of	of	IN
cord-018572-e2qq4ngq	425	20	the	the	DT
cord-018572-e2qq4ngq	425	21	ADP	ADP	NNP
cord-018572-e2qq4ngq	425	22	-	-	HYPH
cord-018572-e2qq4ngq	425	23	ribosylation	ribosylation	NNP
cord-018572-e2qq4ngq	425	24	factor	factor	NN
cord-018572-e2qq4ngq	425	25	family	family	NN
cord-018572-e2qq4ngq	425	26	of	of	IN
cord-018572-e2qq4ngq	425	27	GTPases	gtpase	NNS
cord-018572-e2qq4ngq	425	28	:	:	:
cord-018572-e2qq4ngq	425	29	phylogeny	phylogeny	NN
cord-018572-e2qq4ngq	425	30	among	among	IN
cord-018572-e2qq4ngq	425	31	diverse	diverse	JJ
cord-018572-e2qq4ngq	425	32	eukaryotes	eukaryote	NNS
cord-018572-e2qq4ngq	425	33	and	and	CC
cord-018572-e2qq4ngq	425	34	function	function	NN
cord-018572-e2qq4ngq	425	35	in	in	IN
cord-018572-e2qq4ngq	425	36	C.	C.	NNP
cord-018572-e2qq4ngq	425	37	elegans	elegan	NNS
cord-018572-e2qq4ngq	425	38	ARL4D	ARL4D	.
cord-018572-e2qq4ngq	426	1	recruits	recruit	NNS
cord-018572-e2qq4ngq	426	2	cytohesin-2	cytohesin-2	NNP
cord-018572-e2qq4ngq	426	3	/	/	SYM
cord-018572-e2qq4ngq	426	4	ARNO	ARNO	NNP
cord-018572-e2qq4ngq	426	5	to	to	TO
cord-018572-e2qq4ngq	426	6	modulate	modulate	VB
cord-018572-e2qq4ngq	426	7	actin	actin	JJ
cord-018572-e2qq4ngq	426	8	remodeling	remodeling	NN
cord-018572-e2qq4ngq	426	9	The	the	DT
cord-018572-e2qq4ngq	426	10	CNK1	CNK1	NNP
cord-018572-e2qq4ngq	426	11	scaffold	scaffold	NN
cord-018572-e2qq4ngq	426	12	binds	bind	VBZ
cord-018572-e2qq4ngq	426	13	cytohesins	cytohesin	NNS
cord-018572-e2qq4ngq	426	14	and	and	CC
cord-018572-e2qq4ngq	426	15	promotes	promote	VBZ
cord-018572-e2qq4ngq	426	16	insulin	insulin	NN
cord-018572-e2qq4ngq	426	17	pathway	pathway	NN
cord-018572-e2qq4ngq	426	18	signaling	signal	VBG
cord-018572-e2qq4ngq	426	19	Dynamic	dynamic	JJ
cord-018572-e2qq4ngq	426	20	structure	structure	NN
cord-018572-e2qq4ngq	426	21	of	of	IN
cord-018572-e2qq4ngq	426	22	membrane	membrane	NN
cord-018572-e2qq4ngq	426	23	-	-	HYPH
cord-018572-e2qq4ngq	426	24	anchored	anchor	VBN
cord-018572-e2qq4ngq	426	25	Arf*GTP	Arf*GTP	NNP
cord-018572-e2qq4ngq	426	26	Role	Role	NNP
cord-018572-e2qq4ngq	426	27	of	of	IN
cord-018572-e2qq4ngq	426	28	PAT	PAT	NNP
cord-018572-e2qq4ngq	426	29	proteins	protein	NNS
cord-018572-e2qq4ngq	426	30	in	in	IN
cord-018572-e2qq4ngq	426	31	lipid	lipid	NN
cord-018572-e2qq4ngq	426	32	metabolism	metabolism	NN
cord-018572-e2qq4ngq	426	33	ADP	adp	NN
cord-018572-e2qq4ngq	426	34	-	-	HYPH
cord-018572-e2qq4ngq	426	35	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	426	36	factor	factor	NN
cord-018572-e2qq4ngq	426	37	guanine	guanine	NN
cord-018572-e2qq4ngq	426	38	nucleotideexchange	nucleotideexchange	NN
cord-018572-e2qq4ngq	426	39	factor	factor	NN
cord-018572-e2qq4ngq	426	40	2	2	CD
cord-018572-e2qq4ngq	426	41	(	(	-LRB-
cord-018572-e2qq4ngq	426	42	ARFGEF2	arfgef2	NN
cord-018572-e2qq4ngq	426	43	)	)	-RRB-
cord-018572-e2qq4ngq	426	44	:	:	:
cord-018572-e2qq4ngq	427	1	a	a	DT
cord-018572-e2qq4ngq	427	2	new	new	JJ
cord-018572-e2qq4ngq	427	3	potential	potential	JJ
cord-018572-e2qq4ngq	427	4	biomarker	biomarker	NN
cord-018572-e2qq4ngq	427	5	in	in	IN
cord-018572-e2qq4ngq	427	6	Huntington	Huntington	NNP
cord-018572-e2qq4ngq	427	7	's	's	POS
cord-018572-e2qq4ngq	427	8	disease	disease	NN
cord-018572-e2qq4ngq	427	9	Specificities	Specificities	NNPS
cord-018572-e2qq4ngq	427	10	for	for	IN
cord-018572-e2qq4ngq	427	11	the	the	DT
cord-018572-e2qq4ngq	427	12	small	small	JJ
cord-018572-e2qq4ngq	427	13	G	g	NN
cord-018572-e2qq4ngq	427	14	proteins	protein	NNS
cord-018572-e2qq4ngq	427	15	ARF1	ARF1	NNP
cord-018572-e2qq4ngq	427	16	and	and	CC
cord-018572-e2qq4ngq	427	17	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	427	18	of	of	IN
cord-018572-e2qq4ngq	427	19	the	the	DT
cord-018572-e2qq4ngq	427	20	guanine	guanine	NN
cord-018572-e2qq4ngq	427	21	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	427	22	exchange	exchange	NN
cord-018572-e2qq4ngq	427	23	factors	factor	NNS
cord-018572-e2qq4ngq	427	24	ARNO	ARNO	NNP
cord-018572-e2qq4ngq	427	25	and	and	CC
cord-018572-e2qq4ngq	427	26	EFA6	EFA6	NNP
cord-018572-e2qq4ngq	427	27	Structural	Structural	NNP
cord-018572-e2qq4ngq	428	1	basis	basis	NN
cord-018572-e2qq4ngq	428	2	for	for	IN
cord-018572-e2qq4ngq	428	3	membrane	membrane	NN
cord-018572-e2qq4ngq	428	4	recruitment	recruitment	NN
cord-018572-e2qq4ngq	428	5	and	and	CC
cord-018572-e2qq4ngq	428	6	allosteric	allosteric	JJ
cord-018572-e2qq4ngq	428	7	activation	activation	NN
cord-018572-e2qq4ngq	428	8	of	of	IN
cord-018572-e2qq4ngq	428	9	cytohesin	cytohesin	NNP
cord-018572-e2qq4ngq	428	10	family	family	NN
cord-018572-e2qq4ngq	428	11	Arf	Arf	NNP
cord-018572-e2qq4ngq	428	12	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	428	13	exchange	exchange	NN
cord-018572-e2qq4ngq	428	14	factors	factor	NNS
cord-018572-e2qq4ngq	428	15	Distinct	distinct	JJ
cord-018572-e2qq4ngq	428	16	functions	function	NNS
cord-018572-e2qq4ngq	428	17	for	for	IN
cord-018572-e2qq4ngq	428	18	Arf	arf	NN
cord-018572-e2qq4ngq	428	19	guanine	guanine	NN
cord-018572-e2qq4ngq	428	20	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	428	21	exchange	exchange	NN
cord-018572-e2qq4ngq	428	22	factors	factor	NNS
cord-018572-e2qq4ngq	428	23	at	at	IN
cord-018572-e2qq4ngq	428	24	the	the	DT
cord-018572-e2qq4ngq	428	25	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	428	26	complex	complex	NN
cord-018572-e2qq4ngq	428	27	:	:	:
cord-018572-e2qq4ngq	428	28	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	428	29	and	and	CC
cord-018572-e2qq4ngq	428	30	BIGs	BIGs	NNP
cord-018572-e2qq4ngq	428	31	are	be	VBP
cord-018572-e2qq4ngq	428	32	required	require	VBN
cord-018572-e2qq4ngq	428	33	for	for	IN
cord-018572-e2qq4ngq	428	34	assembly	assembly	NN
cord-018572-e2qq4ngq	428	35	and	and	CC
cord-018572-e2qq4ngq	428	36	maintenance	maintenance	NN
cord-018572-e2qq4ngq	428	37	of	of	IN
cord-018572-e2qq4ngq	428	38	the	the	DT
cord-018572-e2qq4ngq	428	39	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	428	40	stack	stack	NN
cord-018572-e2qq4ngq	428	41	and	and	CC
cord-018572-e2qq4ngq	428	42	trans	trans	JJ
cord-018572-e2qq4ngq	428	43	-	-	JJ
cord-018572-e2qq4ngq	428	44	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	428	45	network	network	NN
cord-018572-e2qq4ngq	428	46	,	,	,
cord-018572-e2qq4ngq	428	47	respectively	respectively	RB
cord-018572-e2qq4ngq	428	48	Arf3	Arf3	NNP
cord-018572-e2qq4ngq	428	49	is	be	VBZ
cord-018572-e2qq4ngq	428	50	activated	activate	VBN
cord-018572-e2qq4ngq	428	51	uniquely	uniquely	RB
cord-018572-e2qq4ngq	428	52	at	at	IN
cord-018572-e2qq4ngq	428	53	the	the	DT
cord-018572-e2qq4ngq	428	54	trans	trans	NNP
cord-018572-e2qq4ngq	428	55	-	-	NNP
cord-018572-e2qq4ngq	428	56	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	428	57	network	network	NN
cord-018572-e2qq4ngq	428	58	by	by	IN
cord-018572-e2qq4ngq	428	59	brefeldin	brefeldin	NNP
cord-018572-e2qq4ngq	428	60	A	A	NNP
cord-018572-e2qq4ngq	428	61	-	-	HYPH
cord-018572-e2qq4ngq	428	62	inhibited	inhibited	JJ
cord-018572-e2qq4ngq	428	63	guanine	guanine	NN
cord-018572-e2qq4ngq	428	64	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	428	65	exchange	exchange	NN
cord-018572-e2qq4ngq	428	66	factors	factor	NNS
cord-018572-e2qq4ngq	429	1	The	the	DT
cord-018572-e2qq4ngq	429	2	TBC	TBC	NNP
cord-018572-e2qq4ngq	429	3	(	(	-LRB-
cord-018572-e2qq4ngq	429	4	Tre-2	Tre-2	NNP
cord-018572-e2qq4ngq	429	5	/	/	,
cord-018572-e2qq4ngq	429	6	Bub2	Bub2	NNP
cord-018572-e2qq4ngq	429	7	/	/	SYM
cord-018572-e2qq4ngq	429	8	Cdc16	Cdc16	NNP
cord-018572-e2qq4ngq	429	9	)	)	-RRB-
cord-018572-e2qq4ngq	429	10	domain	domain	NN
cord-018572-e2qq4ngq	430	1	protein	protein	NNP
cord-018572-e2qq4ngq	430	2	TRE17	TRE17	NNP
cord-018572-e2qq4ngq	430	3	regulates	regulate	VBZ
cord-018572-e2qq4ngq	430	4	plasma	plasma	NN
cord-018572-e2qq4ngq	430	5	membrane	membrane	NN
cord-018572-e2qq4ngq	430	6	-	-	HYPH
cord-018572-e2qq4ngq	430	7	endosomal	endosomal	NNP
cord-018572-e2qq4ngq	430	8	trafficking	trafficking	NN
cord-018572-e2qq4ngq	430	9	through	through	IN
cord-018572-e2qq4ngq	430	10	activation	activation	NN
cord-018572-e2qq4ngq	430	11	of	of	IN
cord-018572-e2qq4ngq	430	12	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	430	13	Role	Role	NNP
cord-018572-e2qq4ngq	430	14	for	for	IN
cord-018572-e2qq4ngq	430	15	ADP	ADP	NNP
cord-018572-e2qq4ngq	430	16	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	430	17	factor	factor	NN
cord-018572-e2qq4ngq	430	18	1	1	CD
cord-018572-e2qq4ngq	430	19	in	in	IN
cord-018572-e2qq4ngq	430	20	the	the	DT
cord-018572-e2qq4ngq	430	21	regulation	regulation	NN
cord-018572-e2qq4ngq	430	22	of	of	IN
cord-018572-e2qq4ngq	430	23	hepatitis	hepatitis	NN
cord-018572-e2qq4ngq	430	24	C	C	NNP
cord-018572-e2qq4ngq	430	25	virus	virus	NN
cord-018572-e2qq4ngq	430	26	replication	replication	NN
cord-018572-e2qq4ngq	430	27	Ciliary	Ciliary	NNP
cord-018572-e2qq4ngq	430	28	targeting	target	VBG
cord-018572-e2qq4ngq	430	29	motif	motif	NN
cord-018572-e2qq4ngq	430	30	VxPx	VxPx	NNP
cord-018572-e2qq4ngq	430	31	directs	direct	VBZ
cord-018572-e2qq4ngq	430	32	assembly	assembly	NN
cord-018572-e2qq4ngq	430	33	of	of	IN
cord-018572-e2qq4ngq	430	34	a	a	DT
cord-018572-e2qq4ngq	430	35	trafficking	trafficking	NN
cord-018572-e2qq4ngq	430	36	module	module	NN
cord-018572-e2qq4ngq	430	37	through	through	IN
cord-018572-e2qq4ngq	430	38	Arf4	Arf4	NNP
cord-018572-e2qq4ngq	430	39	Two	two	CD
cord-018572-e2qq4ngq	430	40	lipid	lipid	NN
cord-018572-e2qq4ngq	430	41	-	-	HYPH
cord-018572-e2qq4ngq	430	42	packing	pack	VBG
cord-018572-e2qq4ngq	430	43	sensor	sensor	NN
cord-018572-e2qq4ngq	430	44	motifs	motif	NNS
cord-018572-e2qq4ngq	430	45	contribute	contribute	VBP
cord-018572-e2qq4ngq	430	46	to	to	IN
cord-018572-e2qq4ngq	430	47	the	the	DT
cord-018572-e2qq4ngq	430	48	sensitivity	sensitivity	NN
cord-018572-e2qq4ngq	430	49	of	of	IN
cord-018572-e2qq4ngq	430	50	ArfGAP1	arfgap1	NN
cord-018572-e2qq4ngq	430	51	to	to	IN
cord-018572-e2qq4ngq	430	52	membrane	membrane	NN
cord-018572-e2qq4ngq	431	1	curvature	curvature	NN
cord-018572-e2qq4ngq	432	1	A	a	DT
cord-018572-e2qq4ngq	432	2	four	four	CD
cord-018572-e2qq4ngq	432	3	-	-	HYPH
cord-018572-e2qq4ngq	432	4	step	step	NN
cord-018572-e2qq4ngq	432	5	cycle	cycle	NN
cord-018572-e2qq4ngq	432	6	driven	drive	VBN
cord-018572-e2qq4ngq	432	7	by	by	IN
cord-018572-e2qq4ngq	432	8	PI(4)P	pi(4)p	JJ
cord-018572-e2qq4ngq	432	9	hydrolysis	hydrolysis	NN
cord-018572-e2qq4ngq	432	10	directs	direct	VBZ
cord-018572-e2qq4ngq	432	11	sterol	sterol	NN
cord-018572-e2qq4ngq	432	12	/	/	SYM
cord-018572-e2qq4ngq	432	13	PI(4)P	PI(4)P	NNP
cord-018572-e2qq4ngq	432	14	exchange	exchange	NN
cord-018572-e2qq4ngq	432	15	by	by	IN
cord-018572-e2qq4ngq	432	16	the	the	DT
cord-018572-e2qq4ngq	432	17	ER	ER	NNP
cord-018572-e2qq4ngq	432	18	-	-	HYPH
cord-018572-e2qq4ngq	432	19	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	432	20	tether	tether	NN
cord-018572-e2qq4ngq	432	21	OSBP	OSBP	NNP
cord-018572-e2qq4ngq	432	22	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	432	23	Interacts	interact	VBZ
cord-018572-e2qq4ngq	432	24	with	with	IN
cord-018572-e2qq4ngq	432	25	JIP4	JIP4	NNP
cord-018572-e2qq4ngq	433	1	to	to	TO
cord-018572-e2qq4ngq	433	2	control	control	VB
cord-018572-e2qq4ngq	433	3	a	a	DT
cord-018572-e2qq4ngq	433	4	motor	motor	NN
cord-018572-e2qq4ngq	433	5	switch	switch	NN
cord-018572-e2qq4ngq	433	6	mechanism	mechanism	NN
cord-018572-e2qq4ngq	433	7	regulating	regulate	VBG
cord-018572-e2qq4ngq	433	8	endosome	endosome	NN
cord-018572-e2qq4ngq	433	9	traffic	traffic	NN
cord-018572-e2qq4ngq	433	10	in	in	IN
cord-018572-e2qq4ngq	433	11	cytokinesis	cytokinesis	NN
cord-018572-e2qq4ngq	433	12	Decoupling	decoupling	NN
cord-018572-e2qq4ngq	433	13	of	of	IN
cord-018572-e2qq4ngq	433	14	activation	activation	NN
cord-018572-e2qq4ngq	433	15	and	and	CC
cord-018572-e2qq4ngq	433	16	effector	effector	NN
cord-018572-e2qq4ngq	433	17	binding	binding	NN
cord-018572-e2qq4ngq	433	18	underlies	underlie	VBZ
cord-018572-e2qq4ngq	433	19	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	433	20	priming	priming	NN
cord-018572-e2qq4ngq	433	21	of	of	IN
cord-018572-e2qq4ngq	434	1	fast	fast	JJ
cord-018572-e2qq4ngq	434	2	endocytic	endocytic	NNP
cord-018572-e2qq4ngq	434	3	recycling	recycling	NN
cord-018572-e2qq4ngq	434	4	BRAG2	BRAG2	NNP
cord-018572-e2qq4ngq	434	5	/	/	SYM
cord-018572-e2qq4ngq	434	6	GEP100	GEP100	NNP
cord-018572-e2qq4ngq	434	7	/	/	SYM
cord-018572-e2qq4ngq	434	8	IQSec1	IQSec1	NNP
cord-018572-e2qq4ngq	434	9	interacts	interact	VBZ
cord-018572-e2qq4ngq	434	10	with	with	IN
cord-018572-e2qq4ngq	434	11	clathrin	clathrin	NN
cord-018572-e2qq4ngq	434	12	and	and	CC
cord-018572-e2qq4ngq	434	13	regulates	regulate	VBZ
cord-018572-e2qq4ngq	434	14	alpha5beta1	alpha5beta1	NNP
cord-018572-e2qq4ngq	434	15	integrin	integrin	NN
cord-018572-e2qq4ngq	434	16	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	434	17	through	through	IN
cord-018572-e2qq4ngq	434	18	activation	activation	NN
cord-018572-e2qq4ngq	434	19	of	of	IN
cord-018572-e2qq4ngq	434	20	ADP	ADP	NNP
cord-018572-e2qq4ngq	434	21	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	434	22	factor	factor	NN
cord-018572-e2qq4ngq	434	23	5	5	CD
cord-018572-e2qq4ngq	435	1	(	(	-LRB-
cord-018572-e2qq4ngq	435	2	Arf5	Arf5	NNP
cord-018572-e2qq4ngq	435	3	)	)	-RRB-
cord-018572-e2qq4ngq	435	4	ASAP1	asap1	NN
cord-018572-e2qq4ngq	435	5	promotes	promote	VBZ
cord-018572-e2qq4ngq	435	6	tumor	tumor	NN
cord-018572-e2qq4ngq	435	7	cell	cell	NN
cord-018572-e2qq4ngq	435	8	motility	motility	NN
cord-018572-e2qq4ngq	435	9	and	and	CC
cord-018572-e2qq4ngq	435	10	invasiveness	invasiveness	NN
cord-018572-e2qq4ngq	435	11	,	,	,
cord-018572-e2qq4ngq	435	12	stimulates	stimulate	VBZ
cord-018572-e2qq4ngq	435	13	metastasis	metastasis	NN
cord-018572-e2qq4ngq	435	14	formation	formation	NN
cord-018572-e2qq4ngq	435	15	in	in	IN
cord-018572-e2qq4ngq	435	16	vivo	vivo	NN
cord-018572-e2qq4ngq	435	17	,	,	,
cord-018572-e2qq4ngq	435	18	and	and	CC
cord-018572-e2qq4ngq	435	19	correlates	correlate	VBZ
cord-018572-e2qq4ngq	435	20	with	with	IN
cord-018572-e2qq4ngq	435	21	poor	poor	JJ
cord-018572-e2qq4ngq	435	22	survival	survival	NN
cord-018572-e2qq4ngq	435	23	in	in	IN
cord-018572-e2qq4ngq	435	24	colorectal	colorectal	JJ
cord-018572-e2qq4ngq	435	25	cancer	cancer	NN
cord-018572-e2qq4ngq	435	26	patients	patient	NNS
cord-018572-e2qq4ngq	436	1	Arf6-GEF	arf6-gef	NN
cord-018572-e2qq4ngq	437	1	BRAG1	BRAG1	NNP
cord-018572-e2qq4ngq	437	2	regulates	regulate	VBZ
cord-018572-e2qq4ngq	437	3	JNK	JNK	NNP
cord-018572-e2qq4ngq	437	4	-	-	HYPH
cord-018572-e2qq4ngq	437	5	mediated	mediate	VBN
cord-018572-e2qq4ngq	437	6	synaptic	synaptic	JJ
cord-018572-e2qq4ngq	437	7	removal	removal	NN
cord-018572-e2qq4ngq	437	8	of	of	IN
cord-018572-e2qq4ngq	437	9	GluA1-containing	glua1-containe	VBG
cord-018572-e2qq4ngq	437	10	AMPA	AMPA	NNP
cord-018572-e2qq4ngq	437	11	receptors	receptor	NNS
cord-018572-e2qq4ngq	437	12	:	:	:
cord-018572-e2qq4ngq	438	1	a	a	DT
cord-018572-e2qq4ngq	438	2	new	new	JJ
cord-018572-e2qq4ngq	438	3	mechanism	mechanism	NN
cord-018572-e2qq4ngq	438	4	for	for	IN
cord-018572-e2qq4ngq	438	5	nonsyndromic	nonsyndromic	NNP
cord-018572-e2qq4ngq	438	6	X	X	NNP
cord-018572-e2qq4ngq	438	7	-	-	HYPH
cord-018572-e2qq4ngq	438	8	linked	link	VBN
cord-018572-e2qq4ngq	438	9	mental	mental	JJ
cord-018572-e2qq4ngq	438	10	disorder	disorder	NN
cord-018572-e2qq4ngq	439	1	A	a	DT
cord-018572-e2qq4ngq	439	2	bacterial	bacterial	JJ
cord-018572-e2qq4ngq	439	3	guanine	guanine	NN
cord-018572-e2qq4ngq	439	4	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	439	5	exchange	exchange	NN
cord-018572-e2qq4ngq	439	6	factor	factor	NN
cord-018572-e2qq4ngq	439	7	activates	activate	VBZ
cord-018572-e2qq4ngq	439	8	ARF	ARF	NNP
cord-018572-e2qq4ngq	439	9	on	on	IN
cord-018572-e2qq4ngq	439	10	Legionella	Legionella	NNP
cord-018572-e2qq4ngq	439	11	phagosomes	phagosomes	NNP
cord-018572-e2qq4ngq	439	12	ARF1	ARF1	NNP
cord-018572-e2qq4ngq	439	13	and	and	CC
cord-018572-e2qq4ngq	439	14	ARF4	ARF4	NNP
cord-018572-e2qq4ngq	439	15	regulate	regulate	VB
cord-018572-e2qq4ngq	439	16	recycling	recycle	VBG
cord-018572-e2qq4ngq	439	17	endosomal	endosomal	NNP
cord-018572-e2qq4ngq	439	18	morphology	morphology	NN
cord-018572-e2qq4ngq	439	19	and	and	CC
cord-018572-e2qq4ngq	439	20	retrograde	retrograde	JJ
cord-018572-e2qq4ngq	439	21	transport	transport	NN
cord-018572-e2qq4ngq	439	22	from	from	IN
cord-018572-e2qq4ngq	439	23	endosomes	endosome	NNS
cord-018572-e2qq4ngq	439	24	to	to	IN
cord-018572-e2qq4ngq	439	25	the	the	DT
cord-018572-e2qq4ngq	439	26	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	439	27	apparatus	apparatus	NN
cord-018572-e2qq4ngq	440	1	ARF1	ARF1	NNP
cord-018572-e2qq4ngq	440	2	mediates	mediate	VBZ
cord-018572-e2qq4ngq	440	3	paxillin	paxillin	NNP
cord-018572-e2qq4ngq	440	4	recruitment	recruitment	NN
cord-018572-e2qq4ngq	440	5	to	to	IN
cord-018572-e2qq4ngq	440	6	focal	focal	JJ
cord-018572-e2qq4ngq	440	7	adhesions	adhesion	NNS
cord-018572-e2qq4ngq	440	8	and	and	CC
cord-018572-e2qq4ngq	440	9	potentiates	potentiate	VBZ
cord-018572-e2qq4ngq	440	10	Rho	rho	NN
cord-018572-e2qq4ngq	440	11	-	-	HYPH
cord-018572-e2qq4ngq	440	12	stimulated	stimulate	VBN
cord-018572-e2qq4ngq	440	13	stress	stress	NN
cord-018572-e2qq4ngq	440	14	fiber	fiber	NN
cord-018572-e2qq4ngq	440	15	formation	formation	NN
cord-018572-e2qq4ngq	440	16	in	in	IN
cord-018572-e2qq4ngq	440	17	intact	intact	JJ
cord-018572-e2qq4ngq	440	18	and	and	CC
cord-018572-e2qq4ngq	440	19	permeabilized	permeabilized	JJ
cord-018572-e2qq4ngq	440	20	Swiss	swiss	JJ
cord-018572-e2qq4ngq	440	21	3T3	3t3	CD
cord-018572-e2qq4ngq	440	22	fibroblasts	fibroblast	NNS
cord-018572-e2qq4ngq	440	23	Cdc42	Cdc42	NNP
cord-018572-e2qq4ngq	440	24	localization	localization	NN
cord-018572-e2qq4ngq	440	25	and	and	CC
cord-018572-e2qq4ngq	440	26	cell	cell	NN
cord-018572-e2qq4ngq	440	27	polarity	polarity	NN
cord-018572-e2qq4ngq	440	28	depend	depend	VBP
cord-018572-e2qq4ngq	440	29	on	on	IN
cord-018572-e2qq4ngq	440	30	membrane	membrane	NN
cord-018572-e2qq4ngq	440	31	traffic	traffic	NN
cord-018572-e2qq4ngq	441	1	The	the	DT
cord-018572-e2qq4ngq	441	2	small	small	JJ
cord-018572-e2qq4ngq	441	3	G	g	NN
cord-018572-e2qq4ngq	441	4	-	-	HYPH
cord-018572-e2qq4ngq	441	5	protein	protein	NN
cord-018572-e2qq4ngq	441	6	Arf6GTP	Arf6GTP	NNP
cord-018572-e2qq4ngq	441	7	recruits	recruit	VBZ
cord-018572-e2qq4ngq	441	8	the	the	DT
cord-018572-e2qq4ngq	441	9	AP-2	AP-2	NNP
cord-018572-e2qq4ngq	441	10	adaptor	adaptor	NN
cord-018572-e2qq4ngq	441	11	complex	complex	JJ
cord-018572-e2qq4ngq	441	12	to	to	IN
cord-018572-e2qq4ngq	442	1	membranes	membrane	NNS
cord-018572-e2qq4ngq	442	2	MAT2B	MAT2B	NNP
cord-018572-e2qq4ngq	442	3	-	-	:
cord-018572-e2qq4ngq	442	4	GIT1	GIT1	NNP
cord-018572-e2qq4ngq	442	5	interplay	interplay	NN
cord-018572-e2qq4ngq	442	6	activates	activate	VBZ
cord-018572-e2qq4ngq	442	7	MEK1/	MEK1/	NNP
cord-018572-e2qq4ngq	442	8	ERK	ERK	NNP
cord-018572-e2qq4ngq	442	9	1	1	CD
cord-018572-e2qq4ngq	442	10	and	and	CC
cord-018572-e2qq4ngq	442	11	2	2	CD
cord-018572-e2qq4ngq	442	12	to	to	TO
cord-018572-e2qq4ngq	442	13	induce	induce	VB
cord-018572-e2qq4ngq	442	14	growth	growth	NN
cord-018572-e2qq4ngq	442	15	in	in	IN
cord-018572-e2qq4ngq	442	16	human	human	JJ
cord-018572-e2qq4ngq	442	17	liver	liver	NN
cord-018572-e2qq4ngq	442	18	and	and	CC
cord-018572-e2qq4ngq	442	19	colon	colon	NN
cord-018572-e2qq4ngq	442	20	cancer	cancer	NN
cord-018572-e2qq4ngq	442	21	Nucleotide	Nucleotide	NNP
cord-018572-e2qq4ngq	442	22	exchange	exchange	NN
cord-018572-e2qq4ngq	442	23	on	on	IN
cord-018572-e2qq4ngq	442	24	ARF	arf	NN
cord-018572-e2qq4ngq	442	25	mediated	mediate	VBN
cord-018572-e2qq4ngq	442	26	by	by	IN
cord-018572-e2qq4ngq	442	27	yeast	yeast	NN
cord-018572-e2qq4ngq	442	28	Gea1	Gea1	NNP
cord-018572-e2qq4ngq	442	29	protein	protein	NN
cord-018572-e2qq4ngq	443	1	The	the	DT
cord-018572-e2qq4ngq	443	2	ARF	ARF	NNP
cord-018572-e2qq4ngq	443	3	exchange	exchange	NN
cord-018572-e2qq4ngq	443	4	factors	factor	NNS
cord-018572-e2qq4ngq	443	5	Gea1p	gea1p	VBP
cord-018572-e2qq4ngq	443	6	and	and	CC
cord-018572-e2qq4ngq	443	7	Gea2p	Gea2p	NNP
cord-018572-e2qq4ngq	443	8	regulate	regulate	VBP
cord-018572-e2qq4ngq	443	9	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	443	10	structure	structure	NN
cord-018572-e2qq4ngq	443	11	and	and	CC
cord-018572-e2qq4ngq	443	12	function	function	NN
cord-018572-e2qq4ngq	443	13	in	in	IN
cord-018572-e2qq4ngq	443	14	yeast	yeast	NN
cord-018572-e2qq4ngq	443	15	Matrix	Matrix	NNP
cord-018572-e2qq4ngq	443	16	invasion	invasion	NN
cord-018572-e2qq4ngq	443	17	by	by	IN
cord-018572-e2qq4ngq	443	18	tumour	tumour	NN
cord-018572-e2qq4ngq	443	19	cells	cell	NNS
cord-018572-e2qq4ngq	443	20	:	:	:
cord-018572-e2qq4ngq	443	21	a	a	DT
cord-018572-e2qq4ngq	443	22	focus	focus	NN
cord-018572-e2qq4ngq	443	23	on	on	IN
cord-018572-e2qq4ngq	443	24	MT1-MMP	MT1-MMP	NNP
cord-018572-e2qq4ngq	443	25	trafficking	traffic	VBG
cord-018572-e2qq4ngq	443	26	to	to	IN
cord-018572-e2qq4ngq	443	27	invadopodia	invadopodia	VB
cord-018572-e2qq4ngq	443	28	Several	several	JJ
cord-018572-e2qq4ngq	443	29	ADP	ADP	NNP
cord-018572-e2qq4ngq	443	30	-	-	HYPH
cord-018572-e2qq4ngq	443	31	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	443	32	factor	factor	NN
cord-018572-e2qq4ngq	444	1	(	(	-LRB-
cord-018572-e2qq4ngq	444	2	Arf	Arf	NNP
cord-018572-e2qq4ngq	444	3	)	)	-RRB-
cord-018572-e2qq4ngq	444	4	isoforms	isoform	NNS
cord-018572-e2qq4ngq	444	5	support	support	VBP
cord-018572-e2qq4ngq	444	6	COPI	COPI	NNP
cord-018572-e2qq4ngq	444	7	vesicle	vesicle	NN
cord-018572-e2qq4ngq	444	8	formation	formation	NN
cord-018572-e2qq4ngq	444	9	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	444	10	regulates	regulate	VBZ
cord-018572-e2qq4ngq	444	11	angiotensin	angiotensin	NN
cord-018572-e2qq4ngq	444	12	II	ii	CD
cord-018572-e2qq4ngq	444	13	type	type	NN
cord-018572-e2qq4ngq	444	14	1	1	CD
cord-018572-e2qq4ngq	444	15	receptor	receptor	NN
cord-018572-e2qq4ngq	444	16	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	444	17	by	by	IN
cord-018572-e2qq4ngq	444	18	controlling	control	VBG
cord-018572-e2qq4ngq	444	19	the	the	DT
cord-018572-e2qq4ngq	444	20	recruitment	recruitment	NN
cord-018572-e2qq4ngq	444	21	of	of	IN
cord-018572-e2qq4ngq	445	1	AP-2	AP-2	NNP
cord-018572-e2qq4ngq	445	2	and	and	CC
cord-018572-e2qq4ngq	445	3	clathrin	clathrin	VB
cord-018572-e2qq4ngq	445	4	Trypanosoma	Trypanosoma	NNP
cord-018572-e2qq4ngq	445	5	brucei	brucei	NNP
cord-018572-e2qq4ngq	445	6	ARF1	ARF1	NNP
cord-018572-e2qq4ngq	445	7	plays	play	VBZ
cord-018572-e2qq4ngq	445	8	a	a	DT
cord-018572-e2qq4ngq	445	9	central	central	JJ
cord-018572-e2qq4ngq	445	10	role	role	NN
cord-018572-e2qq4ngq	445	11	in	in	IN
cord-018572-e2qq4ngq	445	12	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	445	13	and	and	CC
cord-018572-e2qq4ngq	445	14	golgi	golgi	NN
cord-018572-e2qq4ngq	445	15	-	-	HYPH
cord-018572-e2qq4ngq	445	16	lysosome	lysosome	NN
cord-018572-e2qq4ngq	445	17	trafficking	traffic	VBG
cord-018572-e2qq4ngq	445	18	A	a	DT
cord-018572-e2qq4ngq	445	19	CREB3-ARF4	CREB3-ARF4	NNP
cord-018572-e2qq4ngq	445	20	signalling	signal	VBG
cord-018572-e2qq4ngq	445	21	pathway	pathway	NN
cord-018572-e2qq4ngq	446	1	mediates	mediate	VBZ
cord-018572-e2qq4ngq	446	2	the	the	DT
cord-018572-e2qq4ngq	446	3	response	response	NN
cord-018572-e2qq4ngq	446	4	to	to	IN
cord-018572-e2qq4ngq	446	5	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	446	6	stress	stress	NN
cord-018572-e2qq4ngq	446	7	and	and	CC
cord-018572-e2qq4ngq	446	8	susceptibility	susceptibility	NN
cord-018572-e2qq4ngq	446	9	to	to	IN
cord-018572-e2qq4ngq	446	10	pathogens	pathogen	NNS
cord-018572-e2qq4ngq	446	11	Structural	structural	JJ
cord-018572-e2qq4ngq	446	12	basis	basis	NN
cord-018572-e2qq4ngq	446	13	for	for	IN
cord-018572-e2qq4ngq	446	14	recruitment	recruitment	NN
cord-018572-e2qq4ngq	446	15	and	and	CC
cord-018572-e2qq4ngq	446	16	activation	activation	NN
cord-018572-e2qq4ngq	446	17	of	of	IN
cord-018572-e2qq4ngq	446	18	the	the	DT
cord-018572-e2qq4ngq	446	19	AP-1	AP-1	NNP
cord-018572-e2qq4ngq	446	20	clathrin	clathrin	NN
cord-018572-e2qq4ngq	446	21	adaptor	adaptor	NN
cord-018572-e2qq4ngq	446	22	complex	complex	NN
cord-018572-e2qq4ngq	446	23	by	by	IN
cord-018572-e2qq4ngq	446	24	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	446	25	The	the	DT
cord-018572-e2qq4ngq	446	26	Sec7	Sec7	NNP
cord-018572-e2qq4ngq	446	27	Arf	Arf	NNP
cord-018572-e2qq4ngq	446	28	-	-	HYPH
cord-018572-e2qq4ngq	446	29	GEF	GEF	NNP
cord-018572-e2qq4ngq	446	30	is	be	VBZ
cord-018572-e2qq4ngq	446	31	recruited	recruit	VBN
cord-018572-e2qq4ngq	446	32	to	to	IN
cord-018572-e2qq4ngq	446	33	the	the	DT
cord-018572-e2qq4ngq	446	34	trans	trans	NNP
cord-018572-e2qq4ngq	446	35	-	-	NNP
cord-018572-e2qq4ngq	446	36	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	446	37	network	network	NN
cord-018572-e2qq4ngq	446	38	by	by	IN
cord-018572-e2qq4ngq	446	39	positive	positive	JJ
cord-018572-e2qq4ngq	446	40	feedback	feedback	NN
cord-018572-e2qq4ngq	446	41	Protein	protein	NN
cord-018572-e2qq4ngq	446	42	sorting	sorting	NN
cord-018572-e2qq4ngq	446	43	by	by	IN
cord-018572-e2qq4ngq	446	44	transport	transport	NN
cord-018572-e2qq4ngq	446	45	vesicles	vesicle	NNS
cord-018572-e2qq4ngq	446	46	ArfGAP	arfgap	VBP
cord-018572-e2qq4ngq	446	47	family	family	NN
cord-018572-e2qq4ngq	446	48	proteins	protein	NNS
cord-018572-e2qq4ngq	446	49	in	in	IN
cord-018572-e2qq4ngq	446	50	cell	cell	NN
cord-018572-e2qq4ngq	446	51	adhesion	adhesion	NN
cord-018572-e2qq4ngq	446	52	,	,	,
cord-018572-e2qq4ngq	446	53	migration	migration	NN
cord-018572-e2qq4ngq	446	54	and	and	CC
cord-018572-e2qq4ngq	446	55	tumor	tumor	NN
cord-018572-e2qq4ngq	446	56	invasion	invasion	NN
cord-018572-e2qq4ngq	447	1	The	the	DT
cord-018572-e2qq4ngq	447	2	EGFR	EGFR	NNP
cord-018572-e2qq4ngq	447	3	-	-	HYPH
cord-018572-e2qq4ngq	447	4	GEP100-Arf6-AMAP1	GEP100-Arf6-AMAP1	NNP
cord-018572-e2qq4ngq	447	5	signaling	signal	VBG
cord-018572-e2qq4ngq	447	6	pathway	pathway	NN
cord-018572-e2qq4ngq	447	7	specific	specific	JJ
cord-018572-e2qq4ngq	447	8	to	to	IN
cord-018572-e2qq4ngq	447	9	breast	breast	NN
cord-018572-e2qq4ngq	447	10	cancer	cancer	NN
cord-018572-e2qq4ngq	447	11	invasion	invasion	NN
cord-018572-e2qq4ngq	447	12	and	and	CC
cord-018572-e2qq4ngq	447	13	metastasis	metastasis	NN
cord-018572-e2qq4ngq	447	14	Interaction	Interaction	NNP
cord-018572-e2qq4ngq	447	15	of	of	IN
cord-018572-e2qq4ngq	447	16	calciumdependent	calciumdependent	NN
cord-018572-e2qq4ngq	447	17	activator	activator	NN
cord-018572-e2qq4ngq	447	18	protein	protein	NN
cord-018572-e2qq4ngq	447	19	for	for	IN
cord-018572-e2qq4ngq	447	20	secretion	secretion	NN
cord-018572-e2qq4ngq	447	21	1	1	CD
cord-018572-e2qq4ngq	447	22	(	(	-LRB-
cord-018572-e2qq4ngq	447	23	CAPS1	caps1	NN
cord-018572-e2qq4ngq	447	24	)	)	-RRB-
cord-018572-e2qq4ngq	447	25	with	with	IN
cord-018572-e2qq4ngq	447	26	the	the	DT
cord-018572-e2qq4ngq	447	27	class	class	NN
cord-018572-e2qq4ngq	447	28	II	II	NNP
cord-018572-e2qq4ngq	447	29	ADP	ADP	NNP
cord-018572-e2qq4ngq	447	30	-	-	HYPH
cord-018572-e2qq4ngq	447	31	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	447	32	factor	factor	NN
cord-018572-e2qq4ngq	447	33	small	small	JJ
cord-018572-e2qq4ngq	447	34	GTPases	gtpase	NNS
cord-018572-e2qq4ngq	447	35	is	be	VBZ
cord-018572-e2qq4ngq	447	36	required	require	VBN
cord-018572-e2qq4ngq	447	37	for	for	IN
cord-018572-e2qq4ngq	447	38	dense	dense	JJ
cord-018572-e2qq4ngq	447	39	-	-	HYPH
cord-018572-e2qq4ngq	447	40	core	core	NN
cord-018572-e2qq4ngq	447	41	vesicle	vesicle	NN
cord-018572-e2qq4ngq	447	42	trafficking	traffic	VBG
cord-018572-e2qq4ngq	447	43	in	in	IN
cord-018572-e2qq4ngq	447	44	the	the	DT
cord-018572-e2qq4ngq	447	45	trans	trans	NNP
cord-018572-e2qq4ngq	447	46	-	-	NNP
cord-018572-e2qq4ngq	447	47	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	447	48	network	network	NN
cord-018572-e2qq4ngq	447	49	Involvement	Involvement	NNP
cord-018572-e2qq4ngq	447	50	of	of	IN
cord-018572-e2qq4ngq	447	51	small	small	JJ
cord-018572-e2qq4ngq	447	52	ArfGAP1	ArfGAP1	.
cord-018572-e2qq4ngq	447	53	(	(	-LRB-
cord-018572-e2qq4ngq	447	54	SMAP1	SMAP1	NNP
cord-018572-e2qq4ngq	447	55	)	)	-RRB-
cord-018572-e2qq4ngq	447	56	,	,	,
cord-018572-e2qq4ngq	447	57	a	a	DT
cord-018572-e2qq4ngq	447	58	novel	novel	JJ
cord-018572-e2qq4ngq	447	59	Arf6-specific	Arf6-specific	NNP
cord-018572-e2qq4ngq	447	60	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	447	61	-	-	HYPH
cord-018572-e2qq4ngq	447	62	activating	activate	VBG
cord-018572-e2qq4ngq	447	63	protein	protein	NN
cord-018572-e2qq4ngq	447	64	,	,	,
cord-018572-e2qq4ngq	447	65	in	in	IN
cord-018572-e2qq4ngq	447	66	microsatellite	microsatellite	JJ
cord-018572-e2qq4ngq	447	67	instability	instability	NN
cord-018572-e2qq4ngq	447	68	oncogenesis	oncogenesis	NN
cord-018572-e2qq4ngq	447	69	Ancient	ancient	JJ
cord-018572-e2qq4ngq	447	70	complexity	complexity	NN
cord-018572-e2qq4ngq	447	71	,	,	,
cord-018572-e2qq4ngq	447	72	opisthokont	opisthokont	JJ
cord-018572-e2qq4ngq	447	73	plasticity	plasticity	NN
cord-018572-e2qq4ngq	447	74	,	,	,
cord-018572-e2qq4ngq	447	75	and	and	CC
cord-018572-e2qq4ngq	447	76	discovery	discovery	NN
cord-018572-e2qq4ngq	447	77	of	of	IN
cord-018572-e2qq4ngq	447	78	the	the	DT
cord-018572-e2qq4ngq	447	79	11th	11th	JJ
cord-018572-e2qq4ngq	447	80	subfamily	subfamily	NN
cord-018572-e2qq4ngq	447	81	of	of	IN
cord-018572-e2qq4ngq	447	82	Arf	Arf	NNP
cord-018572-e2qq4ngq	447	83	GAP	GAP	NNP
cord-018572-e2qq4ngq	447	84	proteins	protein	VBZ
cord-018572-e2qq4ngq	447	85	Requirements	requirement	NNS
cord-018572-e2qq4ngq	447	86	for	for	IN
cord-018572-e2qq4ngq	447	87	cholera	cholera	NN
cord-018572-e2qq4ngq	447	88	toxin	toxin	NN
cord-018572-e2qq4ngq	447	89	-	-	HYPH
cord-018572-e2qq4ngq	447	90	dependent	dependent	JJ
cord-018572-e2qq4ngq	447	91	ADP	adp	NN
cord-018572-e2qq4ngq	447	92	-	-	HYPH
cord-018572-e2qq4ngq	447	93	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	447	94	of	of	IN
cord-018572-e2qq4ngq	447	95	the	the	DT
cord-018572-e2qq4ngq	447	96	purified	purify	VBN
cord-018572-e2qq4ngq	447	97	regulatory	regulatory	JJ
cord-018572-e2qq4ngq	447	98	component	component	NN
cord-018572-e2qq4ngq	447	99	of	of	IN
cord-018572-e2qq4ngq	447	100	adenylate	adenylate	NN
cord-018572-e2qq4ngq	447	101	cyclase	cyclase	NN
cord-018572-e2qq4ngq	447	102	AMPA	AMPA	NNP
cord-018572-e2qq4ngq	447	103	receptor	receptor	NN
cord-018572-e2qq4ngq	447	104	signaling	signal	VBG
cord-018572-e2qq4ngq	447	105	through	through	IN
cord-018572-e2qq4ngq	447	106	BRAG2	BRAG2	NNP
cord-018572-e2qq4ngq	447	107	and	and	CC
cord-018572-e2qq4ngq	447	108	Arf6	Arf6	NNP
cord-018572-e2qq4ngq	447	109	critical	critical	JJ
cord-018572-e2qq4ngq	447	110	for	for	IN
cord-018572-e2qq4ngq	447	111	long	long	JJ
cord-018572-e2qq4ngq	447	112	-	-	HYPH
cord-018572-e2qq4ngq	447	113	term	term	NN
cord-018572-e2qq4ngq	447	114	synaptic	synaptic	JJ
cord-018572-e2qq4ngq	447	115	depression	depression	NN
cord-018572-e2qq4ngq	447	116	ARF6-mediated	ARF6-mediated	NNP
cord-018572-e2qq4ngq	447	117	endocytic	endocytic	JJ
cord-018572-e2qq4ngq	447	118	recycling	recycling	NN
cord-018572-e2qq4ngq	447	119	impacts	impact	NNS
cord-018572-e2qq4ngq	447	120	cell	cell	NN
cord-018572-e2qq4ngq	447	121	movement	movement	NN
cord-018572-e2qq4ngq	447	122	,	,	,
cord-018572-e2qq4ngq	447	123	cell	cell	NN
cord-018572-e2qq4ngq	447	124	division	division	NN
cord-018572-e2qq4ngq	447	125	and	and	CC
cord-018572-e2qq4ngq	447	126	lipid	lipid	NN
cord-018572-e2qq4ngq	447	127	homeostasis	homeostasis	NN
cord-018572-e2qq4ngq	447	128	Rab	Rab	NNP
cord-018572-e2qq4ngq	447	129	and	and	CC
cord-018572-e2qq4ngq	447	130	Arf	Arf	NNP
cord-018572-e2qq4ngq	447	131	proteins	protein	NNS
cord-018572-e2qq4ngq	447	132	in	in	IN
cord-018572-e2qq4ngq	447	133	genetic	genetic	JJ
cord-018572-e2qq4ngq	447	134	diseases	disease	NNS
cord-018572-e2qq4ngq	448	1	Mutations	mutation	NNS
cord-018572-e2qq4ngq	448	2	in	in	IN
cord-018572-e2qq4ngq	448	3	ARFGEF2	arfgef2	NN
cord-018572-e2qq4ngq	448	4	implicate	implicate	VBP
cord-018572-e2qq4ngq	448	5	vesicle	vesicle	NN
cord-018572-e2qq4ngq	448	6	trafficking	trafficking	NN
cord-018572-e2qq4ngq	448	7	in	in	IN
cord-018572-e2qq4ngq	448	8	neural	neural	JJ
cord-018572-e2qq4ngq	448	9	progenitor	progenitor	NN
cord-018572-e2qq4ngq	448	10	proliferation	proliferation	NN
cord-018572-e2qq4ngq	448	11	and	and	CC
cord-018572-e2qq4ngq	448	12	migration	migration	NN
cord-018572-e2qq4ngq	448	13	in	in	IN
cord-018572-e2qq4ngq	448	14	the	the	DT
cord-018572-e2qq4ngq	448	15	human	human	JJ
cord-018572-e2qq4ngq	448	16	cerebral	cerebral	JJ
cord-018572-e2qq4ngq	448	17	cortex	cortex	NNP
cord-018572-e2qq4ngq	448	18	Mutations	Mutations	NNPS
cord-018572-e2qq4ngq	448	19	in	in	IN
cord-018572-e2qq4ngq	448	20	the	the	DT
cord-018572-e2qq4ngq	448	21	guanine	guanine	NN
cord-018572-e2qq4ngq	448	22	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	448	23	exchange	exchange	NN
cord-018572-e2qq4ngq	448	24	factor	factor	NN
cord-018572-e2qq4ngq	448	25	gene	gene	NNP
cord-018572-e2qq4ngq	448	26	IQSEC2	IQSEC2	NNP
cord-018572-e2qq4ngq	448	27	cause	cause	NN
cord-018572-e2qq4ngq	448	28	nonsyndromic	nonsyndromic	NNP
cord-018572-e2qq4ngq	448	29	intellectual	intellectual	JJ
cord-018572-e2qq4ngq	448	30	disability	disability	NN
cord-018572-e2qq4ngq	449	1	Subtle	subtle	JJ
cord-018572-e2qq4ngq	449	2	functional	functional	JJ
cord-018572-e2qq4ngq	449	3	defects	defect	NNS
cord-018572-e2qq4ngq	449	4	in	in	IN
cord-018572-e2qq4ngq	449	5	the	the	DT
cord-018572-e2qq4ngq	449	6	Arf	Arf	NNP
cord-018572-e2qq4ngq	449	7	-	-	HYPH
cord-018572-e2qq4ngq	449	8	specific	specific	JJ
cord-018572-e2qq4ngq	449	9	guanine	guanine	NN
cord-018572-e2qq4ngq	449	10	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	449	11	exchange	exchange	NN
cord-018572-e2qq4ngq	449	12	factor	factor	NN
cord-018572-e2qq4ngq	450	1	IQSEC2	IQSEC2	''
cord-018572-e2qq4ngq	451	1	cause	cause	VB
cord-018572-e2qq4ngq	451	2	non	non	JJ
cord-018572-e2qq4ngq	451	3	-	-	JJ
cord-018572-e2qq4ngq	451	4	syndromic	syndromic	JJ
cord-018572-e2qq4ngq	451	5	X	x	NN
cord-018572-e2qq4ngq	451	6	-	-	HYPH
cord-018572-e2qq4ngq	451	7	linked	link	VBN
cord-018572-e2qq4ngq	451	8	intellectual	intellectual	JJ
cord-018572-e2qq4ngq	451	9	disability	disability	NN
cord-018572-e2qq4ngq	451	10	Yeast	Yeast	NNP
cord-018572-e2qq4ngq	451	11	Arf3p	Arf3p	NNP
cord-018572-e2qq4ngq	451	12	modulates	modulate	VBZ
cord-018572-e2qq4ngq	451	13	plasma	plasma	NN
cord-018572-e2qq4ngq	451	14	membrane	membrane	NN
cord-018572-e2qq4ngq	451	15	PtdIns(4,5)P2	PtdIns(4,5)P2	NNP
cord-018572-e2qq4ngq	451	16	levels	level	NNS
cord-018572-e2qq4ngq	451	17	to	to	TO
cord-018572-e2qq4ngq	451	18	facilitate	facilitate	VB
cord-018572-e2qq4ngq	451	19	endocytosis	endocytosis	NN
cord-018572-e2qq4ngq	451	20	Coatomerdependent	Coatomerdependent	NNP
cord-018572-e2qq4ngq	451	21	protein	protein	NN
cord-018572-e2qq4ngq	451	22	delivery	delivery	NN
cord-018572-e2qq4ngq	451	23	to	to	IN
cord-018572-e2qq4ngq	451	24	lipid	lipid	NN
cord-018572-e2qq4ngq	451	25	droplets	droplet	NNS
cord-018572-e2qq4ngq	451	26	Arf	Arf	NNP
cord-018572-e2qq4ngq	451	27	GAPs	gaps	NN
cord-018572-e2qq4ngq	451	28	:	:	:
cord-018572-e2qq4ngq	451	29	gatekeepers	gatekeeper	NNS
cord-018572-e2qq4ngq	451	30	of	of	IN
cord-018572-e2qq4ngq	451	31	vesicle	vesicle	NN
cord-018572-e2qq4ngq	451	32	generation	generation	NN
cord-018572-e2qq4ngq	452	1	GTPase	gtpase	NN
cord-018572-e2qq4ngq	452	2	activity	activity	NN
cord-018572-e2qq4ngq	452	3	and	and	CC
cord-018572-e2qq4ngq	452	4	neuronal	neuronal	JJ
cord-018572-e2qq4ngq	452	5	toxicity	toxicity	NN
cord-018572-e2qq4ngq	452	6	of	of	IN
cord-018572-e2qq4ngq	452	7	Parkinson	Parkinson	NNP
cord-018572-e2qq4ngq	452	8	's	's	POS
cord-018572-e2qq4ngq	452	9	disease	disease	NN
cord-018572-e2qq4ngq	452	10	-	-	HYPH
cord-018572-e2qq4ngq	452	11	associated	associate	VBN
cord-018572-e2qq4ngq	452	12	LRRK2	lrrk2	NN
cord-018572-e2qq4ngq	452	13	is	be	VBZ
cord-018572-e2qq4ngq	452	14	regulated	regulate	VBN
cord-018572-e2qq4ngq	452	15	by	by	IN
cord-018572-e2qq4ngq	452	16	ArfGAP1	arfgap1	NN
cord-018572-e2qq4ngq	452	17	Kinetic	kinetic	JJ
cord-018572-e2qq4ngq	452	18	studies	study	NNS
cord-018572-e2qq4ngq	452	19	of	of	IN
cord-018572-e2qq4ngq	452	20	the	the	DT
cord-018572-e2qq4ngq	452	21	Arf	Arf	NNP
cord-018572-e2qq4ngq	452	22	activator	activator	NN
cord-018572-e2qq4ngq	452	23	Arno	Arno	NNP
cord-018572-e2qq4ngq	452	24	on	on	IN
cord-018572-e2qq4ngq	452	25	model	model	NN
cord-018572-e2qq4ngq	452	26	membranes	membrane	NNS
cord-018572-e2qq4ngq	452	27	in	in	IN
cord-018572-e2qq4ngq	452	28	the	the	DT
cord-018572-e2qq4ngq	452	29	presence	presence	NN
cord-018572-e2qq4ngq	452	30	of	of	IN
cord-018572-e2qq4ngq	452	31	Arf	Arf	NNP
cord-018572-e2qq4ngq	452	32	effectors	effector	NNS
cord-018572-e2qq4ngq	452	33	suggest	suggest	VBP
cord-018572-e2qq4ngq	452	34	control	control	NN
cord-018572-e2qq4ngq	452	35	by	by	IN
cord-018572-e2qq4ngq	452	36	a	a	DT
cord-018572-e2qq4ngq	452	37	positive	positive	JJ
cord-018572-e2qq4ngq	452	38	feedback	feedback	NN
cord-018572-e2qq4ngq	452	39	loop	loop	NN
cord-018572-e2qq4ngq	452	40	ADP	ADP	NNP
cord-018572-e2qq4ngq	452	41	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	452	42	factor	factor	NN
cord-018572-e2qq4ngq	452	43	is	be	VBZ
cord-018572-e2qq4ngq	452	44	an	an	DT
cord-018572-e2qq4ngq	452	45	essential	essential	JJ
cord-018572-e2qq4ngq	452	46	protein	protein	NN
cord-018572-e2qq4ngq	452	47	in	in	IN
cord-018572-e2qq4ngq	452	48	Saccharomyces	Saccharomyces	NNP
cord-018572-e2qq4ngq	452	49	cerevisiae	cerevisiae	NNS
cord-018572-e2qq4ngq	452	50	and	and	CC
cord-018572-e2qq4ngq	452	51	is	be	VBZ
cord-018572-e2qq4ngq	452	52	encoded	encode	VBN
cord-018572-e2qq4ngq	452	53	by	by	IN
cord-018572-e2qq4ngq	452	54	two	two	CD
cord-018572-e2qq4ngq	452	55	genes	gene	NNS
cord-018572-e2qq4ngq	452	56	ADP	ADP	NNP
cord-018572-e2qq4ngq	452	57	-	-	HYPH
cord-018572-e2qq4ngq	452	58	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	452	59	factor	factor	NN
cord-018572-e2qq4ngq	452	60	is	be	VBZ
cord-018572-e2qq4ngq	452	61	functionally	functionally	RB
cord-018572-e2qq4ngq	452	62	and	and	CC
cord-018572-e2qq4ngq	452	63	physically	physically	RB
cord-018572-e2qq4ngq	452	64	associated	associate	VBN
cord-018572-e2qq4ngq	452	65	with	with	IN
cord-018572-e2qq4ngq	452	66	the	the	DT
cord-018572-e2qq4ngq	452	67	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	452	68	complex	complex	JJ
cord-018572-e2qq4ngq	452	69	ER	ER	NNP
cord-018572-e2qq4ngq	452	70	-	-	HYPH
cord-018572-e2qq4ngq	452	71	PM	pm	NN
cord-018572-e2qq4ngq	452	72	connections	connection	NNS
cord-018572-e2qq4ngq	452	73	:	:	:
cord-018572-e2qq4ngq	452	74	sites	site	NNS
cord-018572-e2qq4ngq	452	75	of	of	IN
cord-018572-e2qq4ngq	452	76	information	information	NN
cord-018572-e2qq4ngq	452	77	transfer	transfer	NN
cord-018572-e2qq4ngq	452	78	and	and	CC
cord-018572-e2qq4ngq	452	79	inter	inter	JJ
cord-018572-e2qq4ngq	452	80	-	-	JJ
cord-018572-e2qq4ngq	452	81	organelle	organelle	JJ
cord-018572-e2qq4ngq	452	82	communication	communication	NN
cord-018572-e2qq4ngq	452	83	Crucial	crucial	JJ
cord-018572-e2qq4ngq	452	84	role	role	NN
cord-018572-e2qq4ngq	452	85	of	of	IN
cord-018572-e2qq4ngq	452	86	the	the	DT
cord-018572-e2qq4ngq	452	87	small	small	JJ
cord-018572-e2qq4ngq	452	88	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	452	89	ARF6	ARF6	NNP
cord-018572-e2qq4ngq	452	90	in	in	IN
cord-018572-e2qq4ngq	452	91	hepatic	hepatic	JJ
cord-018572-e2qq4ngq	452	92	cord	cord	NN
cord-018572-e2qq4ngq	452	93	formation	formation	NN
cord-018572-e2qq4ngq	452	94	during	during	IN
cord-018572-e2qq4ngq	452	95	liver	liver	NN
cord-018572-e2qq4ngq	452	96	development	development	NN
cord-018572-e2qq4ngq	452	97	Dissecting	dissect	VBG
cord-018572-e2qq4ngq	452	98	the	the	DT
cord-018572-e2qq4ngq	452	99	role	role	NN
cord-018572-e2qq4ngq	452	100	of	of	IN
cord-018572-e2qq4ngq	452	101	the	the	DT
cord-018572-e2qq4ngq	452	102	ARF	ARF	NNP
cord-018572-e2qq4ngq	452	103	guanine	guanine	NN
cord-018572-e2qq4ngq	452	104	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	452	105	exchange	exchange	NN
cord-018572-e2qq4ngq	452	106	factor	factor	NN
cord-018572-e2qq4ngq	452	107	GBF1	GBF1	NNP
cord-018572-e2qq4ngq	452	108	in	in	IN
cord-018572-e2qq4ngq	452	109	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	452	110	biogenesis	biogenesis	NN
cord-018572-e2qq4ngq	452	111	and	and	CC
cord-018572-e2qq4ngq	452	112	protein	protein	NN
cord-018572-e2qq4ngq	452	113	trafficking	trafficking	NN
cord-018572-e2qq4ngq	452	114	Beta	beta	NN
cord-018572-e2qq4ngq	452	115	-	-	HYPH
cord-018572-e2qq4ngq	452	116	site	site	NN
cord-018572-e2qq4ngq	452	117	APP	app	NN
cord-018572-e2qq4ngq	452	118	-	-	HYPH
cord-018572-e2qq4ngq	452	119	cleaving	cleave	VBG
cord-018572-e2qq4ngq	452	120	enzyme	enzyme	NN
cord-018572-e2qq4ngq	452	121	1	1	CD
cord-018572-e2qq4ngq	452	122	trafficking	trafficking	NN
cord-018572-e2qq4ngq	452	123	and	and	CC
cord-018572-e2qq4ngq	452	124	Alzheimer	Alzheimer	NNP
cord-018572-e2qq4ngq	452	125	's	's	POS
cord-018572-e2qq4ngq	452	126	disease	disease	NN
cord-018572-e2qq4ngq	452	127	pathogenesis	pathogenesis	NN
cord-018572-e2qq4ngq	453	1	The	the	DT
cord-018572-e2qq4ngq	453	2	surface	surface	NN
cord-018572-e2qq4ngq	453	3	of	of	IN
cord-018572-e2qq4ngq	453	4	lipid	lipid	NN
cord-018572-e2qq4ngq	453	5	droplets	droplet	NNS
cord-018572-e2qq4ngq	453	6	is	be	VBZ
cord-018572-e2qq4ngq	453	7	a	a	DT
cord-018572-e2qq4ngq	453	8	phospholipid	phospholipid	NN
cord-018572-e2qq4ngq	453	9	monolayer	monolayer	NN
cord-018572-e2qq4ngq	453	10	with	with	IN
cord-018572-e2qq4ngq	453	11	a	a	DT
cord-018572-e2qq4ngq	453	12	unique	unique	JJ
cord-018572-e2qq4ngq	453	13	Fatty	fatty	JJ
cord-018572-e2qq4ngq	453	14	Acid	acid	NN
cord-018572-e2qq4ngq	453	15	composition	composition	NN
cord-018572-e2qq4ngq	453	16	COPI	COPI	NNP
cord-018572-e2qq4ngq	453	17	buds	bud	VBZ
cord-018572-e2qq4ngq	453	18	60-nm	60-nm	CD
cord-018572-e2qq4ngq	453	19	lipid	lipid	NN
cord-018572-e2qq4ngq	453	20	droplets	droplet	NNS
cord-018572-e2qq4ngq	453	21	from	from	IN
cord-018572-e2qq4ngq	453	22	reconstituted	reconstitute	VBN
cord-018572-e2qq4ngq	453	23	water	water	NN
cord-018572-e2qq4ngq	453	24	-	-	HYPH
cord-018572-e2qq4ngq	453	25	phospholipid	phospholipid	NN
cord-018572-e2qq4ngq	453	26	-	-	HYPH
cord-018572-e2qq4ngq	453	27	triacylglyceride	triacylglyceride	NN
cord-018572-e2qq4ngq	453	28	interfaces	interface	NNS
cord-018572-e2qq4ngq	453	29	,	,	,
cord-018572-e2qq4ngq	453	30	suggesting	suggest	VBG
cord-018572-e2qq4ngq	453	31	a	a	DT
cord-018572-e2qq4ngq	453	32	tension	tension	NN
cord-018572-e2qq4ngq	453	33	clamp	clamp	NN
cord-018572-e2qq4ngq	453	34	function	function	NN
cord-018572-e2qq4ngq	453	35	Multiple	multiple	JJ
cord-018572-e2qq4ngq	453	36	pathways	pathway	NNS
cord-018572-e2qq4ngq	453	37	regulate	regulate	VBP
cord-018572-e2qq4ngq	453	38	endocytic	endocytic	JJ
cord-018572-e2qq4ngq	453	39	coat	coat	NN
cord-018572-e2qq4ngq	453	40	disassembly	disassembly	NN
cord-018572-e2qq4ngq	453	41	in	in	IN
cord-018572-e2qq4ngq	453	42	Saccharomyces	Saccharomyces	NNP
cord-018572-e2qq4ngq	453	43	cerevisiae	cerevisiae	NNS
cord-018572-e2qq4ngq	453	44	for	for	IN
cord-018572-e2qq4ngq	453	45	optimal	optimal	JJ
cord-018572-e2qq4ngq	453	46	downstream	downstream	JJ
cord-018572-e2qq4ngq	453	47	trafficking	traffic	VBG
cord-018572-e2qq4ngq	453	48	Isoform	Isoform	NNP
cord-018572-e2qq4ngq	453	49	-	-	HYPH
cord-018572-e2qq4ngq	453	50	selective	selective	JJ
cord-018572-e2qq4ngq	453	51	effects	effect	NNS
cord-018572-e2qq4ngq	453	52	of	of	IN
cord-018572-e2qq4ngq	453	53	the	the	DT
cord-018572-e2qq4ngq	453	54	depletion	depletion	NN
cord-018572-e2qq4ngq	453	55	of	of	IN
cord-018572-e2qq4ngq	453	56	ADP	adp	NN
cord-018572-e2qq4ngq	453	57	-	-	HYPH
cord-018572-e2qq4ngq	453	58	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	453	59	factors	factor	NNS
cord-018572-e2qq4ngq	453	60	1	1	CD
cord-018572-e2qq4ngq	453	61	-	-	SYM
cord-018572-e2qq4ngq	453	62	5	5	CD
cord-018572-e2qq4ngq	453	63	on	on	IN
cord-018572-e2qq4ngq	453	64	membrane	membrane	NN
cord-018572-e2qq4ngq	453	65	traffic	traffic	NN
cord-018572-e2qq4ngq	453	66	Lipid	lipid	NN
cord-018572-e2qq4ngq	453	67	droplets	droplet	NNS
cord-018572-e2qq4ngq	453	68	and	and	CC
cord-018572-e2qq4ngq	453	69	cellular	cellular	JJ
cord-018572-e2qq4ngq	453	70	lipid	lipid	NN
cord-018572-e2qq4ngq	453	71	metabolism	metabolism	NN
cord-018572-e2qq4ngq	454	1	Differential	differential	JJ
cord-018572-e2qq4ngq	454	2	roles	role	NNS
cord-018572-e2qq4ngq	454	3	of	of	IN
cord-018572-e2qq4ngq	454	4	ArfGAP1	arfgap1	NN
cord-018572-e2qq4ngq	454	5	,	,	,
cord-018572-e2qq4ngq	454	6	ArfGAP2	arfgap2	UH
cord-018572-e2qq4ngq	454	7	,	,	,
cord-018572-e2qq4ngq	454	8	and	and	CC
cord-018572-e2qq4ngq	454	9	ArfGAP3	ArfGAP3	NNS
cord-018572-e2qq4ngq	454	10	in	in	IN
cord-018572-e2qq4ngq	454	11	COPI	COPI	NNP
cord-018572-e2qq4ngq	454	12	trafficking	traffic	VBG
cord-018572-e2qq4ngq	454	13	Methods	method	NNS
cord-018572-e2qq4ngq	454	14	for	for	IN
cord-018572-e2qq4ngq	454	15	a	a	DT
cord-018572-e2qq4ngq	454	16	prompt	prompt	JJ
cord-018572-e2qq4ngq	454	17	and	and	CC
cord-018572-e2qq4ngq	454	18	reliable	reliable	JJ
cord-018572-e2qq4ngq	454	19	laboratory	laboratory	NN
cord-018572-e2qq4ngq	454	20	diagnosis	diagnosis	NN
cord-018572-e2qq4ngq	454	21	of	of	IN
cord-018572-e2qq4ngq	454	22	Pompe	Pompe	NNP
cord-018572-e2qq4ngq	454	23	disease	disease	NN
cord-018572-e2qq4ngq	454	24	:	:	:
cord-018572-e2qq4ngq	454	25	report	report	VB
cord-018572-e2qq4ngq	454	26	from	from	IN
cord-018572-e2qq4ngq	454	27	an	an	DT
cord-018572-e2qq4ngq	454	28	international	international	JJ
cord-018572-e2qq4ngq	454	29	consensus	consensus	NN
cord-018572-e2qq4ngq	454	30	meeting	meet	VBG
cord-018572-e2qq4ngq	454	31	The	the	DT
cord-018572-e2qq4ngq	454	32	adaptor	adaptor	NN
cord-018572-e2qq4ngq	454	33	protein	protein	NN
cord-018572-e2qq4ngq	454	34	and	and	CC
cord-018572-e2qq4ngq	455	1	Arf	Arf	NNP
cord-018572-e2qq4ngq	455	2	GTPase	GTPase	NNP
cord-018572-e2qq4ngq	455	3	-	-	HYPH
cord-018572-e2qq4ngq	455	4	activating	activate	VBG
cord-018572-e2qq4ngq	455	5	protein	protein	NN
cord-018572-e2qq4ngq	456	1	Cat-1	Cat-1	NNP
cord-018572-e2qq4ngq	456	2	/	/	SYM
cord-018572-e2qq4ngq	456	3	Git-1	Git-1	NNP
cord-018572-e2qq4ngq	456	4	is	be	VBZ
cord-018572-e2qq4ngq	456	5	required	require	VBN
cord-018572-e2qq4ngq	456	6	for	for	IN
cord-018572-e2qq4ngq	456	7	cellular	cellular	JJ
cord-018572-e2qq4ngq	456	8	transformation	transformation	NN
cord-018572-e2qq4ngq	456	9	A	a	DT
cord-018572-e2qq4ngq	456	10	structure	structure	NN
cord-018572-e2qq4ngq	456	11	-	-	HYPH
cord-018572-e2qq4ngq	456	12	based	base	VBN
cord-018572-e2qq4ngq	456	13	mechanism	mechanism	NN
cord-018572-e2qq4ngq	456	14	for	for	IN
cord-018572-e2qq4ngq	456	15	Arf1-dependent	Arf1-dependent	NNP
cord-018572-e2qq4ngq	456	16	recruitment	recruitment	NN
cord-018572-e2qq4ngq	456	17	of	of	IN
cord-018572-e2qq4ngq	456	18	coatomer	coatomer	NNP
cord-018572-e2qq4ngq	456	19	to	to	IN
cord-018572-e2qq4ngq	456	20	membranes	membrane	NNS
cord-018572-e2qq4ngq	457	1	Filamin	Filamin	NNP
cord-018572-e2qq4ngq	457	2	A	a	DT
cord-018572-e2qq4ngq	457	3	regulates	regulate	VBZ
cord-018572-e2qq4ngq	457	4	neuronal	neuronal	JJ
cord-018572-e2qq4ngq	457	5	migration	migration	NN
cord-018572-e2qq4ngq	457	6	through	through	IN
cord-018572-e2qq4ngq	457	7	brefeldin	brefeldin	NNP
cord-018572-e2qq4ngq	457	8	A	A	NNP
cord-018572-e2qq4ngq	457	9	-	-	HYPH
cord-018572-e2qq4ngq	457	10	inhibited	inhibited	JJ
cord-018572-e2qq4ngq	457	11	guanine	guanine	NN
cord-018572-e2qq4ngq	457	12	exchange	exchange	NN
cord-018572-e2qq4ngq	457	13	factor	factor	NN
cord-018572-e2qq4ngq	458	1	2-dependent	2-dependent	CD
cord-018572-e2qq4ngq	458	2	Arf1	Arf1	NNP
cord-018572-e2qq4ngq	458	3	activation	activation	NN
cord-018572-e2qq4ngq	458	4	Localization	localization	NN
cord-018572-e2qq4ngq	458	5	of	of	IN
cord-018572-e2qq4ngq	458	6	large	large	JJ
cord-018572-e2qq4ngq	458	7	ADP	adp	JJ
cord-018572-e2qq4ngq	458	8	-	-	HYPH
cord-018572-e2qq4ngq	458	9	ribosylation	ribosylation	NN
cord-018572-e2qq4ngq	458	10	factor	factor	NN
cord-018572-e2qq4ngq	458	11	-	-	HYPH
cord-018572-e2qq4ngq	458	12	guanine	guanine	NN
cord-018572-e2qq4ngq	458	13	nucleotide	nucleotide	JJ
cord-018572-e2qq4ngq	458	14	exchange	exchange	NN
cord-018572-e2qq4ngq	458	15	factors	factor	NNS
cord-018572-e2qq4ngq	458	16	to	to	IN
cord-018572-e2qq4ngq	458	17	different	different	JJ
cord-018572-e2qq4ngq	458	18	Golgi	Golgi	NNP
cord-018572-e2qq4ngq	458	19	compartments	compartment	NNS
cord-018572-e2qq4ngq	458	20	:	:	:
cord-018572-e2qq4ngq	459	1	evidence	evidence	NN
cord-018572-e2qq4ngq	459	2	for	for	IN
cord-018572-e2qq4ngq	459	3	distinct	distinct	JJ
cord-018572-e2qq4ngq	459	4	functions	function	NNS
cord-018572-e2qq4ngq	459	5	in	in	IN
cord-018572-e2qq4ngq	459	6	protein	protein	NN
cord-018572-e2qq4ngq	459	7	traffic	traffic	NN
cord-018572-e2qq4ngq	459	8	Acknowledgements	acknowledgement	NNS
cord-018572-e2qq4ngq	459	9	Work	work	VBP
cord-018572-e2qq4ngq	459	10	in	in	IN
cord-018572-e2qq4ngq	459	11	the	the	DT
cord-018572-e2qq4ngq	459	12	author	author	NN
cord-018572-e2qq4ngq	459	13	's	's	POS
cord-018572-e2qq4ngq	459	14	laboratory	laboratory	NN
cord-018572-e2qq4ngq	459	15	is	be	VBZ
cord-018572-e2qq4ngq	459	16	funded	fund	VBN
cord-018572-e2qq4ngq	459	17	by	by	IN
cord-018572-e2qq4ngq	459	18	grants	grant	NNS
cord-018572-e2qq4ngq	459	19	from	from	IN
cord-018572-e2qq4ngq	459	20	the	the	DT
cord-018572-e2qq4ngq	459	21	Agence	Agence	NNP
cord-018572-e2qq4ngq	459	22	Nationale	Nationale	NNP
cord-018572-e2qq4ngq	459	23	de	de	NNP
cord-018572-e2qq4ngq	459	24	la	la	FW
cord-018572-e2qq4ngq	459	25	Recherche	Recherche	NNP
cord-018572-e2qq4ngq	459	26	(	(	-LRB-
cord-018572-e2qq4ngq	459	27	ANR	ANR	NNP
cord-018572-e2qq4ngq	459	28	)	)	-RRB-
cord-018572-e2qq4ngq	459	29	and	and	CC
cord-018572-e2qq4ngq	459	30	the	the	DT
cord-018572-e2qq4ngq	459	31	Fondation	Fondation	NNP
cord-018572-e2qq4ngq	459	32	pour	pour	NN
cord-018572-e2qq4ngq	459	33	la	la	FW
cord-018572-e2qq4ngq	459	34	Recherche	Recherche	NNP
cord-018572-e2qq4ngq	459	35	Médicale	Médicale	NNP
cord-018572-e2qq4ngq	459	36	(	(	-LRB-
cord-018572-e2qq4ngq	459	37	FRM	FRM	NNP
cord-018572-e2qq4ngq	459	38	)	)	-RRB-
cord-018572-e2qq4ngq	459	39	and	and	CC
cord-018572-e2qq4ngq	459	40	by	by	IN
cord-018572-e2qq4ngq	459	41	the	the	DT
cord-018572-e2qq4ngq	459	42	CNRS	CNRS	NNP
cord-018572-e2qq4ngq	459	43	,	,	,
cord-018572-e2qq4ngq	459	44	France	France	NNP
cord-018572-e2qq4ngq	459	45	.	.	.