id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276358-so390gp4	Nieto-Torres, Jose L.	Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome	2015-11-30		.txt	text/plain	7169	396	49	title: Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome In this report, we demonstrate that SARS-CoV E protein forms protein–lipid channels in ERGIC/Golgi membranes that are permeable to calcium ions, a highly relevant feature never reported before. Previously, we reported that SARS-CoV E protein showed mild selectivity for cations (Na þ and K þ ) when reconstituted in ERGIC/ Golgi membranes, mostly conferred by the negative charges of the lipids (Verdia-Baguena et al., 2012 . Synthetic peptides representing the full-length SARS-CoV E protein, or its transmembrane domain (amino acids 7-38) containing point mutations that inhibited ion channel activity (N15A and V25F), were generated by standard phase synthesis and purified by HPLC, as previously described (Verdia-Baguena et al., 2012) . Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis	./cache/cord-276358-so390gp4.txt	./txt/cord-276358-so390gp4.txt