id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269011-230p8rsf	de Haan, Cornelis A.M.	Molecular Interactions in the Assembly of Coronaviruses	2005-08-31		.txt	text/plain	22956	1052	46	Biochemical and theoretical studies led to a topological model for the MHV M protein Rottier et al., 1984 Rottier et al., , 1986 , in which the polypeptide spans the lipid bilayer three times, leaving a small amino-terminal domain (15-35 residues) in the lumen of intracellular organelles (or outside the virus), whereas the carboxyterminal half of the protein is located on the cytoplasmic side of the membrane (or inside the virion). Using a mutational approach including deletions, insertions, and substitutions, both the transmembrane domain and the cysteine-rich region immediately downstream thereof, but not the carboxy-terminal part of the cytoplasmic tail, were shown to be important for MHV S protein-induced cell-cell fusion (Bos et al., 1995; Chang and Gombold, 2001; Chang et al., 2000) The cleavage requirements of the S proteins for the biological activities of the coronavirus spike remain enigmatic.	./cache/cord-269011-230p8rsf.txt	./txt/cord-269011-230p8rsf.txt