id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255981-3zvwu5bd	Bui, Quynh Trang	Large Arf1 guanine nucleotide exchange factors: evolution, domain structure, and roles in membrane trafficking and human disease	2009-08-11		.txt	text/plain	7122	358	51	The majority of these Arf1 GEFs are high molecular weight proteins, on the order of 200 kDa, and for this reason they have been referred to as the large Arf GEFs. The GBF/Gea and BIG/ Sec7 Arf1 GEFs function in internal membrane systems such as the Golgi apparatus, the trans-Golgi network (TGN) and endosomal pathways (Zhao et al. In this review, we will discuss the evolution of these Arf1 GEFs, and present an analysis of conserved domains that are common to both subfamilies as well as those that are speciWc to either the GBF/Gea or BIG/Sec7 proteins. As described previously, the large Arf1 GEFs have Wve major sequence homology domains that are common to members of both the GBF/Gea and the BIG/Sec7 subfamilies (Mouratou et al. The highly conserved sequence homology domains of the GBF/Gea and the BIG/Sec7 Arf1 GEFs suggest that they have important, conserved functions in evolution, and are likely to be involved in protein-protein interactions.	./cache/cord-255981-3zvwu5bd.txt	./txt/cord-255981-3zvwu5bd.txt