id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017866-h5ttoo0z	Bowman, Grant R.	Biogenesis of Dense-Core Secretory Granules	2010-05-27		.txt	text/plain	13369	678	42	For such regulated exocytosis, the vesicles that carry newly-synthesized protein from the TGN accumulate in the cytoplasm until specific extracellular events trigger their fusion with the plasma membrane, resulting in the release of vesicle contents.f The vesicles involved are called dense-core granules (DCGs), the name reflecting the fact that the contents are so highly condensed that they form a large electron-dense plug in the vesicle lumen. In support of this hypothesis, recent studies have suggested that prohormone convertases 1 and 2, which are responsible for proteolytic cleavageof lumenal proteins during granule maturation, are sorted to ISGs by virtue of C-terminal membrane raft-associated tails, which are by themselves necessary and sufficient for targeting to DCGs,uo 120 Additionally, cytoplasmic signals on some transmembrane proteins appear to play important roles in sorting, but the mechanisms are unknown.	./cache/cord-017866-h5ttoo0z.txt	./txt/cord-017866-h5ttoo0z.txt