id	sid	tid	token	lemma	pos
cord-302047-vv5gpldi	1	1	key	key	JJ
cord-302047-vv5gpldi	1	2	:	:	:
cord-302047-vv5gpldi	1	3	cord-302047-vv5gpldi	cord-302047-vv5gpldi	CD
cord-302047-vv5gpldi	1	4	authors	author	NNS
cord-302047-vv5gpldi	1	5	:	:	:
cord-302047-vv5gpldi	1	6	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	1	7	,	,	,
cord-302047-vv5gpldi	1	8	Anouk	Anouk	NNP
cord-302047-vv5gpldi	1	9	;	;	:
cord-302047-vv5gpldi	1	10	Zwart	Zwart	NNP
cord-302047-vv5gpldi	1	11	,	,	,
cord-302047-vv5gpldi	1	12	Mark	Mark	NNP
cord-302047-vv5gpldi	1	13	P	P	NNP
cord-302047-vv5gpldi	1	14	title	title	NN
cord-302047-vv5gpldi	1	15	:	:	:
cord-302047-vv5gpldi	2	1	On	on	IN
cord-302047-vv5gpldi	2	2	the	the	DT
cord-302047-vv5gpldi	2	3	stability	stability	NN
cord-302047-vv5gpldi	2	4	of	of	IN
cord-302047-vv5gpldi	2	5	sequences	sequence	NNS
cord-302047-vv5gpldi	2	6	inserted	insert	VBN
cord-302047-vv5gpldi	2	7	into	into	IN
cord-302047-vv5gpldi	2	8	viral	viral	JJ
cord-302047-vv5gpldi	2	9	genomes	genome	NNS
cord-302047-vv5gpldi	2	10	date	date	NN
cord-302047-vv5gpldi	2	11	:	:	:
cord-302047-vv5gpldi	2	12	2019	2019	CD
cord-302047-vv5gpldi	2	13	-	-	HYPH
cord-302047-vv5gpldi	2	14	11	11	CD
cord-302047-vv5gpldi	2	15	-	-	SYM
cord-302047-vv5gpldi	2	16	14	14	CD
cord-302047-vv5gpldi	2	17	journal	journal	NN
cord-302047-vv5gpldi	2	18	:	:	:
cord-302047-vv5gpldi	3	1	Virus	Virus	NNP
cord-302047-vv5gpldi	3	2	Evol	Evol	NNP
cord-302047-vv5gpldi	3	3	DOI	DOI	NNP
cord-302047-vv5gpldi	3	4	:	:	:
cord-302047-vv5gpldi	4	1	10.1093	10.1093	CD
cord-302047-vv5gpldi	4	2	/	/	SYM
cord-302047-vv5gpldi	4	3	ve	ve	NNP
cord-302047-vv5gpldi	4	4	/	/	SYM
cord-302047-vv5gpldi	4	5	vez045	vez045	NNP
cord-302047-vv5gpldi	4	6	sha	sha	NNP
cord-302047-vv5gpldi	4	7	:	:	:
cord-302047-vv5gpldi	4	8	f6e985e472df7bba7a7ef1568336c0443b919639	f6e985e472df7bba7a7ef1568336c0443b919639	.
cord-302047-vv5gpldi	4	9	doc_id	doc_id	CD
cord-302047-vv5gpldi	4	10	:	:	:
cord-302047-vv5gpldi	4	11	302047	302047	CD
cord-302047-vv5gpldi	4	12	cord_uid	cord_uid	NNS
cord-302047-vv5gpldi	4	13	:	:	:
cord-302047-vv5gpldi	4	14	vv5gpldi	vv5gpldi	.
cord-302047-vv5gpldi	5	1	Viruses	virus	NNS
cord-302047-vv5gpldi	5	2	are	be	VBP
cord-302047-vv5gpldi	5	3	widely	widely	RB
cord-302047-vv5gpldi	5	4	used	use	VBN
cord-302047-vv5gpldi	5	5	as	as	IN
cord-302047-vv5gpldi	5	6	vectors	vector	NNS
cord-302047-vv5gpldi	5	7	for	for	IN
cord-302047-vv5gpldi	5	8	heterologous	heterologous	JJ
cord-302047-vv5gpldi	5	9	gene	gene	NN
cord-302047-vv5gpldi	5	10	expression	expression	NN
cord-302047-vv5gpldi	5	11	in	in	IN
cord-302047-vv5gpldi	5	12	cultured	cultured	JJ
cord-302047-vv5gpldi	5	13	cells	cell	NNS
cord-302047-vv5gpldi	5	14	or	or	CC
cord-302047-vv5gpldi	5	15	natural	natural	JJ
cord-302047-vv5gpldi	5	16	hosts	host	NNS
cord-302047-vv5gpldi	5	17	,	,	,
cord-302047-vv5gpldi	5	18	and	and	CC
cord-302047-vv5gpldi	5	19	therefore	therefore	RB
cord-302047-vv5gpldi	5	20	a	a	DT
cord-302047-vv5gpldi	5	21	large	large	JJ
cord-302047-vv5gpldi	5	22	number	number	NN
cord-302047-vv5gpldi	5	23	of	of	IN
cord-302047-vv5gpldi	5	24	viruses	virus	NNS
cord-302047-vv5gpldi	5	25	with	with	IN
cord-302047-vv5gpldi	5	26	exogenous	exogenous	JJ
cord-302047-vv5gpldi	5	27	sequences	sequence	NNS
cord-302047-vv5gpldi	5	28	inserted	insert	VBN
cord-302047-vv5gpldi	5	29	into	into	IN
cord-302047-vv5gpldi	5	30	their	-PRON-	PRP$
cord-302047-vv5gpldi	5	31	genomes	genome	NNS
cord-302047-vv5gpldi	5	32	have	have	VBP
cord-302047-vv5gpldi	5	33	been	be	VBN
cord-302047-vv5gpldi	5	34	engineered	engineer	VBN
cord-302047-vv5gpldi	5	35	.	.	.
cord-302047-vv5gpldi	6	1	Many	many	JJ
cord-302047-vv5gpldi	6	2	of	of	IN
cord-302047-vv5gpldi	6	3	these	these	DT
cord-302047-vv5gpldi	6	4	engineered	engineer	VBN
cord-302047-vv5gpldi	6	5	viruses	virus	NNS
cord-302047-vv5gpldi	6	6	are	be	VBP
cord-302047-vv5gpldi	6	7	viable	viable	JJ
cord-302047-vv5gpldi	6	8	and	and	CC
cord-302047-vv5gpldi	6	9	express	express	JJ
cord-302047-vv5gpldi	6	10	heterologous	heterologous	JJ
cord-302047-vv5gpldi	6	11	proteins	protein	NNS
cord-302047-vv5gpldi	6	12	at	at	IN
cord-302047-vv5gpldi	6	13	high	high	JJ
cord-302047-vv5gpldi	6	14	levels	level	NNS
cord-302047-vv5gpldi	6	15	,	,	,
cord-302047-vv5gpldi	6	16	but	but	CC
cord-302047-vv5gpldi	6	17	the	the	DT
cord-302047-vv5gpldi	6	18	inserted	insert	VBN
cord-302047-vv5gpldi	6	19	sequences	sequence	NNS
cord-302047-vv5gpldi	6	20	often	often	RB
cord-302047-vv5gpldi	6	21	prove	prove	VBP
cord-302047-vv5gpldi	6	22	to	to	TO
cord-302047-vv5gpldi	6	23	be	be	VB
cord-302047-vv5gpldi	6	24	unstable	unstable	JJ
cord-302047-vv5gpldi	6	25	over	over	IN
cord-302047-vv5gpldi	6	26	time	time	NN
cord-302047-vv5gpldi	6	27	and	and	CC
cord-302047-vv5gpldi	6	28	are	be	VBP
cord-302047-vv5gpldi	6	29	rapidly	rapidly	RB
cord-302047-vv5gpldi	6	30	lost	lose	VBN
cord-302047-vv5gpldi	6	31	,	,	,
cord-302047-vv5gpldi	6	32	limiting	limit	VBG
cord-302047-vv5gpldi	6	33	heterologous	heterologous	JJ
cord-302047-vv5gpldi	6	34	protein	protein	NN
cord-302047-vv5gpldi	6	35	expression	expression	NN
cord-302047-vv5gpldi	6	36	.	.	.
cord-302047-vv5gpldi	7	1	Although	although	IN
cord-302047-vv5gpldi	7	2	virologists	virologist	NNS
cord-302047-vv5gpldi	7	3	are	be	VBP
cord-302047-vv5gpldi	7	4	aware	aware	JJ
cord-302047-vv5gpldi	7	5	that	that	IN
cord-302047-vv5gpldi	7	6	inserted	insert	VBN
cord-302047-vv5gpldi	7	7	sequences	sequence	NNS
cord-302047-vv5gpldi	7	8	can	can	MD
cord-302047-vv5gpldi	7	9	be	be	VB
cord-302047-vv5gpldi	7	10	unstable	unstable	JJ
cord-302047-vv5gpldi	7	11	,	,	,
cord-302047-vv5gpldi	7	12	processes	process	NNS
cord-302047-vv5gpldi	7	13	leading	lead	VBG
cord-302047-vv5gpldi	7	14	to	to	TO
cord-302047-vv5gpldi	7	15	insert	insert	VB
cord-302047-vv5gpldi	7	16	instability	instability	NN
cord-302047-vv5gpldi	7	17	are	be	VBP
cord-302047-vv5gpldi	7	18	rarely	rarely	RB
cord-302047-vv5gpldi	7	19	considered	consider	VBN
cord-302047-vv5gpldi	7	20	from	from	IN
cord-302047-vv5gpldi	7	21	an	an	DT
cord-302047-vv5gpldi	7	22	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	7	23	perspective	perspective	NN
cord-302047-vv5gpldi	7	24	.	.	.
cord-302047-vv5gpldi	8	1	Here	here	RB
cord-302047-vv5gpldi	8	2	,	,	,
cord-302047-vv5gpldi	8	3	we	-PRON-	PRP
cord-302047-vv5gpldi	8	4	review	review	VBP
cord-302047-vv5gpldi	8	5	experimental	experimental	JJ
cord-302047-vv5gpldi	8	6	work	work	NN
cord-302047-vv5gpldi	8	7	on	on	IN
cord-302047-vv5gpldi	8	8	the	the	DT
cord-302047-vv5gpldi	8	9	stability	stability	NN
cord-302047-vv5gpldi	8	10	of	of	IN
cord-302047-vv5gpldi	8	11	inserted	insert	VBN
cord-302047-vv5gpldi	8	12	sequences	sequence	NNS
cord-302047-vv5gpldi	8	13	over	over	IN
cord-302047-vv5gpldi	8	14	a	a	DT
cord-302047-vv5gpldi	8	15	broad	broad	JJ
cord-302047-vv5gpldi	8	16	range	range	NN
cord-302047-vv5gpldi	8	17	of	of	IN
cord-302047-vv5gpldi	8	18	viruses	virus	NNS
cord-302047-vv5gpldi	8	19	,	,	,
cord-302047-vv5gpldi	8	20	and	and	CC
cord-302047-vv5gpldi	8	21	we	-PRON-	PRP
cord-302047-vv5gpldi	8	22	present	present	VBP
cord-302047-vv5gpldi	8	23	some	some	DT
cord-302047-vv5gpldi	8	24	theoretical	theoretical	JJ
cord-302047-vv5gpldi	8	25	considerations	consideration	NNS
cord-302047-vv5gpldi	8	26	concerning	concern	VBG
cord-302047-vv5gpldi	8	27	insert	insert	JJ
cord-302047-vv5gpldi	8	28	stability	stability	NN
cord-302047-vv5gpldi	8	29	.	.	.
cord-302047-vv5gpldi	9	1	Different	different	JJ
cord-302047-vv5gpldi	9	2	virus	virus	NN
cord-302047-vv5gpldi	9	3	genome	genome	NN
cord-302047-vv5gpldi	9	4	organizations	organization	NNS
cord-302047-vv5gpldi	9	5	strongly	strongly	RB
cord-302047-vv5gpldi	9	6	impact	impact	VBP
cord-302047-vv5gpldi	9	7	insert	insert	NN
cord-302047-vv5gpldi	9	8	stability	stability	NN
cord-302047-vv5gpldi	9	9	,	,	,
cord-302047-vv5gpldi	9	10	and	and	CC
cord-302047-vv5gpldi	9	11	factors	factor	NNS
cord-302047-vv5gpldi	9	12	such	such	JJ
cord-302047-vv5gpldi	9	13	as	as	IN
cord-302047-vv5gpldi	9	14	the	the	DT
cord-302047-vv5gpldi	9	15	position	position	NN
cord-302047-vv5gpldi	9	16	of	of	IN
cord-302047-vv5gpldi	9	17	insertion	insertion	NN
cord-302047-vv5gpldi	9	18	can	can	MD
cord-302047-vv5gpldi	9	19	have	have	VB
cord-302047-vv5gpldi	9	20	a	a	DT
cord-302047-vv5gpldi	9	21	strong	strong	JJ
cord-302047-vv5gpldi	9	22	effect	effect	NN
cord-302047-vv5gpldi	9	23	.	.	.
cord-302047-vv5gpldi	10	1	In	in	IN
cord-302047-vv5gpldi	10	2	addition	addition	NN
cord-302047-vv5gpldi	10	3	,	,	,
cord-302047-vv5gpldi	10	4	we	-PRON-	PRP
cord-302047-vv5gpldi	10	5	argue	argue	VBP
cord-302047-vv5gpldi	10	6	that	that	IN
cord-302047-vv5gpldi	10	7	insert	insert	VBP
cord-302047-vv5gpldi	10	8	stability	stability	NN
cord-302047-vv5gpldi	10	9	not	not	RB
cord-302047-vv5gpldi	10	10	only	only	RB
cord-302047-vv5gpldi	10	11	depends	depend	VBZ
cord-302047-vv5gpldi	10	12	on	on	IN
cord-302047-vv5gpldi	10	13	the	the	DT
cord-302047-vv5gpldi	10	14	characteristics	characteristic	NNS
cord-302047-vv5gpldi	10	15	of	of	IN
cord-302047-vv5gpldi	10	16	a	a	DT
cord-302047-vv5gpldi	10	17	particular	particular	JJ
cord-302047-vv5gpldi	10	18	genome	genome	NN
cord-302047-vv5gpldi	10	19	,	,	,
cord-302047-vv5gpldi	10	20	but	but	CC
cord-302047-vv5gpldi	10	21	that	that	IN
cord-302047-vv5gpldi	10	22	it	-PRON-	PRP
cord-302047-vv5gpldi	10	23	will	will	MD
cord-302047-vv5gpldi	10	24	also	also	RB
cord-302047-vv5gpldi	10	25	depend	depend	VB
cord-302047-vv5gpldi	10	26	on	on	IN
cord-302047-vv5gpldi	10	27	the	the	DT
cord-302047-vv5gpldi	10	28	host	host	NN
cord-302047-vv5gpldi	10	29	environment	environment	NN
cord-302047-vv5gpldi	10	30	and	and	CC
cord-302047-vv5gpldi	10	31	the	the	DT
cord-302047-vv5gpldi	10	32	demography	demography	NN
cord-302047-vv5gpldi	10	33	of	of	IN
cord-302047-vv5gpldi	10	34	a	a	DT
cord-302047-vv5gpldi	10	35	virus	virus	NN
cord-302047-vv5gpldi	10	36	population	population	NN
cord-302047-vv5gpldi	10	37	.	.	.
cord-302047-vv5gpldi	11	1	The	the	DT
cord-302047-vv5gpldi	11	2	interplay	interplay	NN
cord-302047-vv5gpldi	11	3	between	between	IN
cord-302047-vv5gpldi	11	4	all	all	DT
cord-302047-vv5gpldi	11	5	factors	factor	NNS
cord-302047-vv5gpldi	11	6	affecting	affect	VBG
cord-302047-vv5gpldi	11	7	stability	stability	NN
cord-302047-vv5gpldi	11	8	is	be	VBZ
cord-302047-vv5gpldi	11	9	complex	complex	JJ
cord-302047-vv5gpldi	11	10	,	,	,
cord-302047-vv5gpldi	11	11	which	which	WDT
cord-302047-vv5gpldi	11	12	makes	make	VBZ
cord-302047-vv5gpldi	11	13	it	-PRON-	PRP
cord-302047-vv5gpldi	11	14	challenging	challenging	JJ
cord-302047-vv5gpldi	11	15	to	to	TO
cord-302047-vv5gpldi	11	16	develop	develop	VB
cord-302047-vv5gpldi	11	17	a	a	DT
cord-302047-vv5gpldi	11	18	general	general	JJ
cord-302047-vv5gpldi	11	19	model	model	NN
cord-302047-vv5gpldi	11	20	to	to	TO
cord-302047-vv5gpldi	11	21	predict	predict	VB
cord-302047-vv5gpldi	11	22	the	the	DT
cord-302047-vv5gpldi	11	23	stability	stability	NN
cord-302047-vv5gpldi	11	24	of	of	IN
cord-302047-vv5gpldi	11	25	genomic	genomic	JJ
cord-302047-vv5gpldi	11	26	insertions	insertion	NNS
cord-302047-vv5gpldi	11	27	.	.	.
cord-302047-vv5gpldi	12	1	We	-PRON-	PRP
cord-302047-vv5gpldi	12	2	highlight	highlight	VBP
cord-302047-vv5gpldi	12	3	key	key	JJ
cord-302047-vv5gpldi	12	4	questions	question	NNS
cord-302047-vv5gpldi	12	5	and	and	CC
cord-302047-vv5gpldi	12	6	future	future	JJ
cord-302047-vv5gpldi	12	7	directions	direction	NNS
cord-302047-vv5gpldi	12	8	,	,	,
cord-302047-vv5gpldi	12	9	finding	find	VBG
cord-302047-vv5gpldi	12	10	that	that	IN
cord-302047-vv5gpldi	12	11	insert	insert	JJ
cord-302047-vv5gpldi	12	12	stability	stability	NN
cord-302047-vv5gpldi	12	13	is	be	VBZ
cord-302047-vv5gpldi	12	14	a	a	DT
cord-302047-vv5gpldi	12	15	surprisingly	surprisingly	RB
cord-302047-vv5gpldi	12	16	complex	complex	JJ
cord-302047-vv5gpldi	12	17	problem	problem	NN
cord-302047-vv5gpldi	12	18	and	and	CC
cord-302047-vv5gpldi	12	19	that	that	IN
cord-302047-vv5gpldi	12	20	there	there	EX
cord-302047-vv5gpldi	12	21	is	be	VBZ
cord-302047-vv5gpldi	12	22	need	need	NN
cord-302047-vv5gpldi	12	23	for	for	IN
cord-302047-vv5gpldi	12	24	mechanism	mechanism	NN
cord-302047-vv5gpldi	12	25	-	-	HYPH
cord-302047-vv5gpldi	12	26	based	base	VBN
cord-302047-vv5gpldi	12	27	,	,	,
cord-302047-vv5gpldi	12	28	predictive	predictive	JJ
cord-302047-vv5gpldi	12	29	models	model	NNS
cord-302047-vv5gpldi	12	30	.	.	.
cord-302047-vv5gpldi	13	1	Combining	combine	VBG
cord-302047-vv5gpldi	13	2	theoretical	theoretical	JJ
cord-302047-vv5gpldi	13	3	models	model	NNS
cord-302047-vv5gpldi	13	4	with	with	IN
cord-302047-vv5gpldi	13	5	experimental	experimental	JJ
cord-302047-vv5gpldi	13	6	tests	test	NNS
cord-302047-vv5gpldi	13	7	for	for	IN
cord-302047-vv5gpldi	13	8	stability	stability	NN
cord-302047-vv5gpldi	13	9	under	under	IN
cord-302047-vv5gpldi	13	10	varying	vary	VBG
cord-302047-vv5gpldi	13	11	conditions	condition	NNS
cord-302047-vv5gpldi	13	12	can	can	MD
cord-302047-vv5gpldi	13	13	lead	lead	VB
cord-302047-vv5gpldi	13	14	to	to	IN
cord-302047-vv5gpldi	13	15	improved	improve	VBN
cord-302047-vv5gpldi	13	16	engineering	engineering	NN
cord-302047-vv5gpldi	13	17	of	of	IN
cord-302047-vv5gpldi	13	18	viral	viral	JJ
cord-302047-vv5gpldi	13	19	modified	modify	VBN
cord-302047-vv5gpldi	13	20	genomes	genome	NNS
cord-302047-vv5gpldi	13	21	,	,	,
cord-302047-vv5gpldi	13	22	which	which	WDT
cord-302047-vv5gpldi	13	23	is	be	VBZ
cord-302047-vv5gpldi	13	24	a	a	DT
cord-302047-vv5gpldi	13	25	valuable	valuable	JJ
cord-302047-vv5gpldi	13	26	tool	tool	NN
cord-302047-vv5gpldi	13	27	for	for	IN
cord-302047-vv5gpldi	13	28	understanding	understand	VBG
cord-302047-vv5gpldi	13	29	genome	genome	NN
cord-302047-vv5gpldi	13	30	evolution	evolution	NN
cord-302047-vv5gpldi	13	31	as	as	RB
cord-302047-vv5gpldi	13	32	well	well	RB
cord-302047-vv5gpldi	13	33	as	as	IN
cord-302047-vv5gpldi	13	34	for	for	IN
cord-302047-vv5gpldi	13	35	biotechnological	biotechnological	JJ
cord-302047-vv5gpldi	13	36	applications	application	NNS
cord-302047-vv5gpldi	13	37	,	,	,
cord-302047-vv5gpldi	13	38	such	such	JJ
cord-302047-vv5gpldi	13	39	as	as	IN
cord-302047-vv5gpldi	13	40	gene	gene	NN
cord-302047-vv5gpldi	13	41	therapy	therapy	NN
cord-302047-vv5gpldi	13	42	.	.	.
cord-302047-vv5gpldi	14	1	A	a	DT
cord-302047-vv5gpldi	14	2	large	large	JJ
cord-302047-vv5gpldi	14	3	number	number	NN
cord-302047-vv5gpldi	14	4	of	of	IN
cord-302047-vv5gpldi	14	5	virus	virus	NN
cord-302047-vv5gpldi	14	6	genomes	genome	NNS
cord-302047-vv5gpldi	14	7	have	have	VBP
cord-302047-vv5gpldi	14	8	been	be	VBN
cord-302047-vv5gpldi	14	9	engineered	engineer	VBN
cord-302047-vv5gpldi	14	10	to	to	TO
cord-302047-vv5gpldi	14	11	carry	carry	VB
cord-302047-vv5gpldi	14	12	additional	additional	JJ
cord-302047-vv5gpldi	14	13	sequences	sequence	NNS
cord-302047-vv5gpldi	14	14	for	for	IN
cord-302047-vv5gpldi	14	15	a	a	DT
cord-302047-vv5gpldi	14	16	variety	variety	NN
cord-302047-vv5gpldi	14	17	of	of	IN
cord-302047-vv5gpldi	14	18	purposes	purpose	NNS
cord-302047-vv5gpldi	14	19	.	.	.
cord-302047-vv5gpldi	15	1	Viruses	virus	NNS
cord-302047-vv5gpldi	15	2	are	be	VBP
cord-302047-vv5gpldi	15	3	often	often	RB
cord-302047-vv5gpldi	15	4	used	use	VBN
cord-302047-vv5gpldi	15	5	as	as	IN
cord-302047-vv5gpldi	15	6	vectors	vector	NNS
cord-302047-vv5gpldi	15	7	for	for	IN
cord-302047-vv5gpldi	15	8	heterologous	heterologous	JJ
cord-302047-vv5gpldi	15	9	gene	gene	NN
cord-302047-vv5gpldi	15	10	expression	expression	NN
cord-302047-vv5gpldi	15	11	in	in	IN
cord-302047-vv5gpldi	15	12	cultured	cultured	JJ
cord-302047-vv5gpldi	15	13	cells	cell	NNS
cord-302047-vv5gpldi	15	14	or	or	CC
cord-302047-vv5gpldi	15	15	the	the	DT
cord-302047-vv5gpldi	15	16	natural	natural	JJ
cord-302047-vv5gpldi	15	17	host	host	NN
cord-302047-vv5gpldi	15	18	.	.	.
cord-302047-vv5gpldi	16	1	For	for	IN
cord-302047-vv5gpldi	16	2	example	example	NN
cord-302047-vv5gpldi	16	3	,	,	,
cord-302047-vv5gpldi	16	4	the	the	DT
cord-302047-vv5gpldi	16	5	baculovirus	baculovirus	NNP
cord-302047-vv5gpldi	16	6	expression	expression	NN
cord-302047-vv5gpldi	16	7	system	system	NN
cord-302047-vv5gpldi	16	8	is	be	VBZ
cord-302047-vv5gpldi	16	9	widely	widely	RB
cord-302047-vv5gpldi	16	10	used	use	VBN
cord-302047-vv5gpldi	16	11	for	for	IN
cord-302047-vv5gpldi	16	12	expression	expression	NN
cord-302047-vv5gpldi	16	13	work	work	NN
cord-302047-vv5gpldi	16	14	(	(	-LRB-
cord-302047-vv5gpldi	16	15	Chambers	Chambers	NNP
cord-302047-vv5gpldi	16	16	et	et	NNP
cord-302047-vv5gpldi	16	17	al	al	NNP
cord-302047-vv5gpldi	16	18	.	.	.
cord-302047-vv5gpldi	16	19	2018	2018	CD
cord-302047-vv5gpldi	16	20	)	)	-RRB-
cord-302047-vv5gpldi	16	21	,	,	,
cord-302047-vv5gpldi	16	22	lentiviruses	lentiviruses	NNP
cord-302047-vv5gpldi	16	23	show	show	VBP
cord-302047-vv5gpldi	16	24	great	great	JJ
cord-302047-vv5gpldi	16	25	promise	promise	NN
cord-302047-vv5gpldi	16	26	for	for	IN
cord-302047-vv5gpldi	16	27	gene	gene	NN
cord-302047-vv5gpldi	16	28	therapy	therapy	NN
cord-302047-vv5gpldi	16	29	(	(	-LRB-
cord-302047-vv5gpldi	16	30	Milone	Milone	NNP
cord-302047-vv5gpldi	16	31	and	and	CC
cord-302047-vv5gpldi	16	32	O'Doherty	O'Doherty	NNP
cord-302047-vv5gpldi	16	33	2018	2018	CD
cord-302047-vv5gpldi	16	34	)	)	-RRB-
cord-302047-vv5gpldi	16	35	,	,	,
cord-302047-vv5gpldi	16	36	and	and	CC
cord-302047-vv5gpldi	16	37	phage	phage	NN
cord-302047-vv5gpldi	16	38	display	display	NN
cord-302047-vv5gpldi	16	39	allows	allow	VBZ
cord-302047-vv5gpldi	16	40	for	for	IN
cord-302047-vv5gpldi	16	41	selection	selection	NN
cord-302047-vv5gpldi	16	42	of	of	IN
cord-302047-vv5gpldi	16	43	desired	desire	VBN
cord-302047-vv5gpldi	16	44	epitopes	epitope	NNS
cord-302047-vv5gpldi	16	45	(	(	-LRB-
cord-302047-vv5gpldi	16	46	Wu	Wu	NNP
cord-302047-vv5gpldi	16	47	et	et	NNP
cord-302047-vv5gpldi	16	48	al	al	NNP
cord-302047-vv5gpldi	16	49	.	.	.
cord-302047-vv5gpldi	16	50	2016	2016	CD
cord-302047-vv5gpldi	16	51	)	)	-RRB-
cord-302047-vv5gpldi	16	52	.	.	.
cord-302047-vv5gpldi	17	1	Marker	marker	NN
cord-302047-vv5gpldi	17	2	genes	gene	NNS
cord-302047-vv5gpldi	17	3	have	have	VBP
cord-302047-vv5gpldi	17	4	also	also	RB
cord-302047-vv5gpldi	17	5	been	be	VBN
cord-302047-vv5gpldi	17	6	built	build	VBN
cord-302047-vv5gpldi	17	7	into	into	IN
cord-302047-vv5gpldi	17	8	viruses	virus	NNS
cord-302047-vv5gpldi	17	9	to	to	TO
cord-302047-vv5gpldi	17	10	facilitate	facilitate	VB
cord-302047-vv5gpldi	17	11	tracking	track	VBG
cord-302047-vv5gpldi	17	12	infection	infection	NN
cord-302047-vv5gpldi	17	13	spread	spread	NN
cord-302047-vv5gpldi	17	14	(	(	-LRB-
cord-302047-vv5gpldi	17	15	Dolja	Dolja	NNP
cord-302047-vv5gpldi	17	16	,	,	,
cord-302047-vv5gpldi	17	17	McBride	McBride	NNP
cord-302047-vv5gpldi	17	18	,	,	,
cord-302047-vv5gpldi	17	19	and	and	CC
cord-302047-vv5gpldi	17	20	Carrington	Carrington	NNP
cord-302047-vv5gpldi	17	21	1992	1992	CD
cord-302047-vv5gpldi	17	22	)	)	-RRB-
cord-302047-vv5gpldi	17	23	.	.	.
cord-302047-vv5gpldi	18	1	As	as	IN
cord-302047-vv5gpldi	18	2	viruses	virus	NNS
cord-302047-vv5gpldi	18	3	evolve	evolve	VBP
cord-302047-vv5gpldi	18	4	rapidly	rapidly	RB
cord-302047-vv5gpldi	18	5	,	,	,
cord-302047-vv5gpldi	18	6	including	include	VBG
cord-302047-vv5gpldi	18	7	the	the	DT
cord-302047-vv5gpldi	18	8	incorporation	incorporation	NN
cord-302047-vv5gpldi	18	9	of	of	IN
cord-302047-vv5gpldi	18	10	genome	genome	NN
cord-302047-vv5gpldi	18	11	-	-	HYPH
cord-302047-vv5gpldi	18	12	rearrangements	rearrangement	NNS
cord-302047-vv5gpldi	18	13	,	,	,
cord-302047-vv5gpldi	18	14	it	-PRON-	PRP
cord-302047-vv5gpldi	18	15	is	be	VBZ
cord-302047-vv5gpldi	18	16	therefore	therefore	RB
cord-302047-vv5gpldi	18	17	unsurprising	unsurprising	JJ
cord-302047-vv5gpldi	18	18	that	that	IN
cord-302047-vv5gpldi	18	19	the	the	DT
cord-302047-vv5gpldi	18	20	insertion	insertion	NN
cord-302047-vv5gpldi	18	21	of	of	IN
cord-302047-vv5gpldi	18	22	sequences	sequence	NNS
cord-302047-vv5gpldi	18	23	into	into	IN
cord-302047-vv5gpldi	18	24	viral	viral	JJ
cord-302047-vv5gpldi	18	25	genomes	genome	NNS
cord-302047-vv5gpldi	18	26	often	often	RB
cord-302047-vv5gpldi	18	27	goes	go	VBZ
cord-302047-vv5gpldi	18	28	hand	hand	NN
cord-302047-vv5gpldi	18	29	in	in	IN
cord-302047-vv5gpldi	18	30	hand	hand	NN
cord-302047-vv5gpldi	18	31	with	with	IN
cord-302047-vv5gpldi	18	32	the	the	DT
cord-302047-vv5gpldi	18	33	rapid	rapid	JJ
cord-302047-vv5gpldi	18	34	occurrence	occurrence	NN
cord-302047-vv5gpldi	18	35	of	of	IN
cord-302047-vv5gpldi	18	36	deletions	deletion	NNS
cord-302047-vv5gpldi	18	37	(	(	-LRB-
cord-302047-vv5gpldi	18	38	Koonin	Koonin	NNP
cord-302047-vv5gpldi	18	39	,	,	,
cord-302047-vv5gpldi	18	40	Dolja	Dolja	NNP
cord-302047-vv5gpldi	18	41	,	,	,
cord-302047-vv5gpldi	18	42	and	and	CC
cord-302047-vv5gpldi	18	43	Morris	Morris	NNP
cord-302047-vv5gpldi	18	44	1993	1993	CD
cord-302047-vv5gpldi	18	45	;	;	:
cord-302047-vv5gpldi	18	46	Pijlman	Pijlman	NNP
cord-302047-vv5gpldi	18	47	et	et	NNP
cord-302047-vv5gpldi	18	48	al	al	NNP
cord-302047-vv5gpldi	18	49	.	.	NNP
cord-302047-vv5gpldi	18	50	2001	2001	CD
cord-302047-vv5gpldi	18	51	;	;	:
cord-302047-vv5gpldi	18	52	Zwart	Zwart	NNP
cord-302047-vv5gpldi	18	53	et	et	FW
cord-302047-vv5gpldi	18	54	al	al	NNP
cord-302047-vv5gpldi	18	55	.	.	NNP
cord-302047-vv5gpldi	18	56	2014	2014	CD
cord-302047-vv5gpldi	18	57	)	)	-RRB-
cord-302047-vv5gpldi	18	58	.	.	.
cord-302047-vv5gpldi	19	1	The	the	DT
cord-302047-vv5gpldi	19	2	inserted	insert	VBN
cord-302047-vv5gpldi	19	3	sequence	sequence	NN
cord-302047-vv5gpldi	19	4	,	,	,
cord-302047-vv5gpldi	19	5	and	and	CC
cord-302047-vv5gpldi	19	6	sometimes	sometimes	RB
cord-302047-vv5gpldi	19	7	parts	part	NNS
cord-302047-vv5gpldi	19	8	of	of	IN
cord-302047-vv5gpldi	19	9	the	the	DT
cord-302047-vv5gpldi	19	10	viral	viral	JJ
cord-302047-vv5gpldi	19	11	genome	genome	NN
cord-302047-vv5gpldi	19	12	,	,	,
cord-302047-vv5gpldi	19	13	are	be	VBP
cord-302047-vv5gpldi	19	14	then	then	RB
cord-302047-vv5gpldi	19	15	rapidly	rapidly	RB
cord-302047-vv5gpldi	19	16	lost	lose	VBN
cord-302047-vv5gpldi	19	17	.	.	.
cord-302047-vv5gpldi	20	1	This	this	DT
cord-302047-vv5gpldi	20	2	genomic	genomic	JJ
cord-302047-vv5gpldi	20	3	instability	instability	NN
cord-302047-vv5gpldi	20	4	can	can	MD
cord-302047-vv5gpldi	20	5	have	have	VB
cord-302047-vv5gpldi	20	6	economic	economic	JJ
cord-302047-vv5gpldi	20	7	ramifications	ramification	NNS
cord-302047-vv5gpldi	20	8	,	,	,
cord-302047-vv5gpldi	20	9	leading	lead	VBG
cord-302047-vv5gpldi	20	10	to	to	IN
cord-302047-vv5gpldi	20	11	decreases	decrease	NNS
cord-302047-vv5gpldi	20	12	in	in	IN
cord-302047-vv5gpldi	20	13	heterologous	heterologous	JJ
cord-302047-vv5gpldi	20	14	protein	protein	NN
cord-302047-vv5gpldi	20	15	expression	expression	NN
cord-302047-vv5gpldi	21	1	(	(	-LRB-
cord-302047-vv5gpldi	21	2	Kool	Kool	NNP
cord-302047-vv5gpldi	21	3	et	et	NNP
cord-302047-vv5gpldi	21	4	al	al	NNP
cord-302047-vv5gpldi	21	5	.	.	.
cord-302047-vv5gpldi	21	6	1991	1991	CD
cord-302047-vv5gpldi	21	7	;	;	:
cord-302047-vv5gpldi	21	8	De	De	NNP
cord-302047-vv5gpldi	21	9	Gooijer	Gooijer	NNP
cord-302047-vv5gpldi	21	10	et	et	NNP
cord-302047-vv5gpldi	21	11	al	al	NNP
cord-302047-vv5gpldi	21	12	.	.	NNP
cord-302047-vv5gpldi	21	13	1992	1992	CD
cord-302047-vv5gpldi	21	14	;	;	:
cord-302047-vv5gpldi	21	15	Scholthof	Scholthof	NNP
cord-302047-vv5gpldi	21	16	,	,	,
cord-302047-vv5gpldi	21	17	Scholthof	Scholthof	NNP
cord-302047-vv5gpldi	21	18	,	,	,
cord-302047-vv5gpldi	22	1	V	V	NNP
cord-302047-vv5gpldi	22	2	C	C	NNP
cord-302047-vv5gpldi	22	3	The	the	DT
cord-302047-vv5gpldi	22	4	Author(s	Author(s	NNP
cord-302047-vv5gpldi	22	5	)	)	-RRB-
cord-302047-vv5gpldi	22	6	2019	2019	CD
cord-302047-vv5gpldi	22	7	.	.	.
cord-302047-vv5gpldi	23	1	Published	publish	VBN
cord-302047-vv5gpldi	23	2	by	by	IN
cord-302047-vv5gpldi	23	3	Oxford	Oxford	NNP
cord-302047-vv5gpldi	23	4	University	University	NNP
cord-302047-vv5gpldi	23	5	Press	Press	NNP
cord-302047-vv5gpldi	23	6	.	.	.
cord-302047-vv5gpldi	24	1	This	this	DT
cord-302047-vv5gpldi	24	2	is	be	VBZ
cord-302047-vv5gpldi	24	3	an	an	DT
cord-302047-vv5gpldi	24	4	Open	Open	NNP
cord-302047-vv5gpldi	24	5	Access	Access	NNP
cord-302047-vv5gpldi	24	6	article	article	NN
cord-302047-vv5gpldi	24	7	distributed	distribute	VBN
cord-302047-vv5gpldi	24	8	under	under	IN
cord-302047-vv5gpldi	24	9	the	the	DT
cord-302047-vv5gpldi	24	10	terms	term	NNS
cord-302047-vv5gpldi	24	11	of	of	IN
cord-302047-vv5gpldi	24	12	the	the	DT
cord-302047-vv5gpldi	24	13	Creative	Creative	NNP
cord-302047-vv5gpldi	24	14	Commons	Commons	NNP
cord-302047-vv5gpldi	24	15	Attribution	Attribution	NNP
cord-302047-vv5gpldi	24	16	Non	Non	NNP
cord-302047-vv5gpldi	24	17	-	-	JJ
cord-302047-vv5gpldi	24	18	Commercial	commercial	JJ
cord-302047-vv5gpldi	24	19	License	license	NN
cord-302047-vv5gpldi	24	20	(	(	-LRB-
cord-302047-vv5gpldi	24	21	http://creativecommons.org/	http://creativecommons.org/	ADD
cord-302047-vv5gpldi	24	22	licenses	license	NNS
cord-302047-vv5gpldi	24	23	/	/	SYM
cord-302047-vv5gpldi	24	24	by	by	IN
cord-302047-vv5gpldi	24	25	-	-	HYPH
cord-302047-vv5gpldi	24	26	nc/4.0/	nc/4.0/	NN
cord-302047-vv5gpldi	24	27	)	)	-RRB-
cord-302047-vv5gpldi	24	28	,	,	,
cord-302047-vv5gpldi	24	29	which	which	WDT
cord-302047-vv5gpldi	24	30	permits	permit	VBZ
cord-302047-vv5gpldi	24	31	non	non	JJ
cord-302047-vv5gpldi	24	32	-	-	JJ
cord-302047-vv5gpldi	24	33	commercial	commercial	JJ
cord-302047-vv5gpldi	24	34	re	re	NN
cord-302047-vv5gpldi	24	35	-	-	NN
cord-302047-vv5gpldi	24	36	use	use	JJ
cord-302047-vv5gpldi	24	37	,	,	,
cord-302047-vv5gpldi	24	38	distribution	distribution	NN
cord-302047-vv5gpldi	24	39	,	,	,
cord-302047-vv5gpldi	24	40	and	and	CC
cord-302047-vv5gpldi	24	41	reproduction	reproduction	NN
cord-302047-vv5gpldi	24	42	in	in	IN
cord-302047-vv5gpldi	24	43	any	any	DT
cord-302047-vv5gpldi	24	44	medium	medium	NN
cord-302047-vv5gpldi	24	45	,	,	,
cord-302047-vv5gpldi	24	46	provided	provide	VBD
cord-302047-vv5gpldi	24	47	the	the	DT
cord-302047-vv5gpldi	24	48	original	original	JJ
cord-302047-vv5gpldi	24	49	work	work	NN
cord-302047-vv5gpldi	24	50	is	be	VBZ
cord-302047-vv5gpldi	24	51	properly	properly	RB
cord-302047-vv5gpldi	24	52	cited	cite	VBN
cord-302047-vv5gpldi	24	53	.	.	.
cord-302047-vv5gpldi	25	1	For	for	IN
cord-302047-vv5gpldi	25	2	commercial	commercial	JJ
cord-302047-vv5gpldi	25	3	re	re	NN
cord-302047-vv5gpldi	25	4	-	-	NN
cord-302047-vv5gpldi	25	5	use	use	NN
cord-302047-vv5gpldi	25	6	,	,	,
cord-302047-vv5gpldi	25	7	please	please	UH
cord-302047-vv5gpldi	25	8	contact	contact	VB
cord-302047-vv5gpldi	25	9	journals.permissions@oup.com	journals.permissions@oup.com	NNP
cord-302047-vv5gpldi	25	10	and	and	CC
cord-302047-vv5gpldi	25	11	Jackson	Jackson	NNP
cord-302047-vv5gpldi	25	12	1996	1996	CD
cord-302047-vv5gpldi	25	13	)	)	-RRB-
cord-302047-vv5gpldi	25	14	.	.	.
cord-302047-vv5gpldi	26	1	It	-PRON-	PRP
cord-302047-vv5gpldi	26	2	can	can	MD
cord-302047-vv5gpldi	26	3	also	also	RB
cord-302047-vv5gpldi	26	4	introduce	introduce	VB
cord-302047-vv5gpldi	26	5	limitations	limitation	NNS
cord-302047-vv5gpldi	26	6	and	and	CC
cord-302047-vv5gpldi	26	7	complications	complication	NNS
cord-302047-vv5gpldi	26	8	to	to	IN
cord-302047-vv5gpldi	26	9	working	work	VBG
cord-302047-vv5gpldi	26	10	with	with	IN
cord-302047-vv5gpldi	26	11	marker	marker	NN
cord-302047-vv5gpldi	26	12	genes	gene	NNS
cord-302047-vv5gpldi	26	13	Majer	Majer	NNP
cord-302047-vv5gpldi	26	14	,	,	,
cord-302047-vv5gpldi	26	15	Darò	Darò	NNP
cord-302047-vv5gpldi	26	16	s	s	NNP
cord-302047-vv5gpldi	26	17	,	,	,
cord-302047-vv5gpldi	26	18	and	and	CC
cord-302047-vv5gpldi	26	19	Zwart	Zwart	NNP
cord-302047-vv5gpldi	26	20	2013	2013	CD
cord-302047-vv5gpldi	26	21	)	)	-RRB-
cord-302047-vv5gpldi	26	22	.	.	.
cord-302047-vv5gpldi	27	1	Understanding	understand	VBG
cord-302047-vv5gpldi	27	2	the	the	DT
cord-302047-vv5gpldi	27	3	stability	stability	NN
cord-302047-vv5gpldi	27	4	of	of	IN
cord-302047-vv5gpldi	27	5	inserted	insert	VBN
cord-302047-vv5gpldi	27	6	sequences	sequence	NNS
cord-302047-vv5gpldi	27	7	therefore	therefore	RB
cord-302047-vv5gpldi	27	8	has	have	VBZ
cord-302047-vv5gpldi	27	9	value	value	NN
cord-302047-vv5gpldi	27	10	from	from	IN
cord-302047-vv5gpldi	27	11	an	an	DT
cord-302047-vv5gpldi	27	12	applied	apply	VBN
cord-302047-vv5gpldi	27	13	perspective	perspective	NN
cord-302047-vv5gpldi	27	14	,	,	,
cord-302047-vv5gpldi	27	15	but	but	CC
cord-302047-vv5gpldi	27	16	it	-PRON-	PRP
cord-302047-vv5gpldi	27	17	could	could	MD
cord-302047-vv5gpldi	27	18	also	also	RB
cord-302047-vv5gpldi	27	19	shed	shed	VB
cord-302047-vv5gpldi	27	20	light	light	NN
cord-302047-vv5gpldi	27	21	on	on	IN
cord-302047-vv5gpldi	27	22	basic	basic	JJ
cord-302047-vv5gpldi	27	23	questions	question	NNS
cord-302047-vv5gpldi	27	24	.	.	.
cord-302047-vv5gpldi	28	1	First	first	RB
cord-302047-vv5gpldi	28	2	,	,	,
cord-302047-vv5gpldi	28	3	how	how	WRB
cord-302047-vv5gpldi	28	4	stable	stable	JJ
cord-302047-vv5gpldi	28	5	are	be	VBP
cord-302047-vv5gpldi	28	6	natural	natural	JJ
cord-302047-vv5gpldi	28	7	virus	virus	NN
cord-302047-vv5gpldi	28	8	genomes	genome	NNS
cord-302047-vv5gpldi	28	9	,	,	,
cord-302047-vv5gpldi	28	10	and	and	CC
cord-302047-vv5gpldi	28	11	under	under	IN
cord-302047-vv5gpldi	28	12	what	what	WDT
cord-302047-vv5gpldi	28	13	conditions	condition	NNS
cord-302047-vv5gpldi	28	14	do	do	VBP
cord-302047-vv5gpldi	28	15	they	-PRON-	PRP
cord-302047-vv5gpldi	28	16	become	become	VB
cord-302047-vv5gpldi	28	17	unstable	unstable	JJ
cord-302047-vv5gpldi	28	18	?	?	.
cord-302047-vv5gpldi	29	1	Second	second	RB
cord-302047-vv5gpldi	29	2	,	,	,
cord-302047-vv5gpldi	29	3	since	since	IN
cord-302047-vv5gpldi	29	4	horizontal	horizontal	JJ
cord-302047-vv5gpldi	29	5	gene	gene	NN
cord-302047-vv5gpldi	29	6	transfer	transfer	NN
cord-302047-vv5gpldi	29	7	(	(	-LRB-
cord-302047-vv5gpldi	29	8	HGT	HGT	NNP
cord-302047-vv5gpldi	29	9	)	)	-RRB-
cord-302047-vv5gpldi	29	10	plays	play	VBZ
cord-302047-vv5gpldi	29	11	an	an	DT
cord-302047-vv5gpldi	29	12	important	important	JJ
cord-302047-vv5gpldi	29	13	role	role	NN
cord-302047-vv5gpldi	29	14	in	in	IN
cord-302047-vv5gpldi	29	15	virus	virus	NN
cord-302047-vv5gpldi	29	16	evolution	evolution	NN
cord-302047-vv5gpldi	29	17	,	,	,
cord-302047-vv5gpldi	29	18	under	under	IN
cord-302047-vv5gpldi	29	19	what	what	WDT
cord-302047-vv5gpldi	29	20	conditions	condition	NNS
cord-302047-vv5gpldi	29	21	are	be	VBP
cord-302047-vv5gpldi	29	22	transferred	transfer	VBN
cord-302047-vv5gpldi	29	23	sequences	sequence	NNS
cord-302047-vv5gpldi	29	24	likely	likely	JJ
cord-302047-vv5gpldi	29	25	to	to	TO
cord-302047-vv5gpldi	29	26	be	be	VB
cord-302047-vv5gpldi	29	27	retained	retain	VBN
cord-302047-vv5gpldi	29	28	?	?	.
cord-302047-vv5gpldi	30	1	In	in	IN
cord-302047-vv5gpldi	30	2	this	this	DT
cord-302047-vv5gpldi	30	3	review	review	NN
cord-302047-vv5gpldi	30	4	,	,	,
cord-302047-vv5gpldi	30	5	we	-PRON-	PRP
cord-302047-vv5gpldi	30	6	consider	consider	VBP
cord-302047-vv5gpldi	30	7	the	the	DT
cord-302047-vv5gpldi	30	8	stability	stability	NN
cord-302047-vv5gpldi	30	9	of	of	IN
cord-302047-vv5gpldi	30	10	inserted	insert	VBN
cord-302047-vv5gpldi	30	11	sequences	sequence	NNS
cord-302047-vv5gpldi	30	12	and	and	CC
cord-302047-vv5gpldi	30	13	the	the	DT
cord-302047-vv5gpldi	30	14	dynamics	dynamic	NNS
cord-302047-vv5gpldi	30	15	of	of	IN
cord-302047-vv5gpldi	30	16	their	-PRON-	PRP$
cord-302047-vv5gpldi	30	17	removal	removal	NN
cord-302047-vv5gpldi	30	18	from	from	IN
cord-302047-vv5gpldi	30	19	virus	virus	NN
cord-302047-vv5gpldi	30	20	genomes	genome	NNS
cord-302047-vv5gpldi	30	21	from	from	IN
cord-302047-vv5gpldi	30	22	an	an	DT
cord-302047-vv5gpldi	30	23	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	30	24	perspective	perspective	NN
cord-302047-vv5gpldi	30	25	.	.	.
cord-302047-vv5gpldi	31	1	First	first	RB
cord-302047-vv5gpldi	31	2	,	,	,
cord-302047-vv5gpldi	31	3	we	-PRON-	PRP
cord-302047-vv5gpldi	31	4	provide	provide	VBP
cord-302047-vv5gpldi	31	5	an	an	DT
cord-302047-vv5gpldi	31	6	overview	overview	NN
cord-302047-vv5gpldi	31	7	of	of	IN
cord-302047-vv5gpldi	31	8	empirical	empirical	JJ
cord-302047-vv5gpldi	31	9	results	result	NNS
cord-302047-vv5gpldi	31	10	which	which	WDT
cord-302047-vv5gpldi	31	11	shed	shed	VBD
cord-302047-vv5gpldi	31	12	light	light	NN
cord-302047-vv5gpldi	31	13	on	on	IN
cord-302047-vv5gpldi	31	14	insert	insert	JJ
cord-302047-vv5gpldi	31	15	-	-	HYPH
cord-302047-vv5gpldi	31	16	sequence	sequence	NN
cord-302047-vv5gpldi	31	17	stability	stability	NN
cord-302047-vv5gpldi	31	18	for	for	IN
cord-302047-vv5gpldi	31	19	viruses	virus	NNS
cord-302047-vv5gpldi	31	20	,	,	,
cord-302047-vv5gpldi	31	21	based	base	VBN
cord-302047-vv5gpldi	31	22	on	on	IN
cord-302047-vv5gpldi	31	23	the	the	DT
cord-302047-vv5gpldi	31	24	Baltimore	Baltimore	NNP
cord-302047-vv5gpldi	31	25	classification	classification	NN
cord-302047-vv5gpldi	31	26	.	.	.
cord-302047-vv5gpldi	32	1	Second	second	RB
cord-302047-vv5gpldi	32	2	,	,	,
cord-302047-vv5gpldi	32	3	we	-PRON-	PRP
cord-302047-vv5gpldi	32	4	present	present	VBP
cord-302047-vv5gpldi	32	5	some	some	DT
cord-302047-vv5gpldi	32	6	conceptual	conceptual	JJ
cord-302047-vv5gpldi	32	7	considerations	consideration	NNS
cord-302047-vv5gpldi	32	8	pertaining	pertain	VBG
cord-302047-vv5gpldi	32	9	to	to	IN
cord-302047-vv5gpldi	32	10	sequence	sequence	NN
cord-302047-vv5gpldi	32	11	stability	stability	NN
cord-302047-vv5gpldi	32	12	,	,	,
cord-302047-vv5gpldi	32	13	identifying	identify	VBG
cord-302047-vv5gpldi	32	14	important	important	JJ
cord-302047-vv5gpldi	32	15	parameters	parameter	NNS
cord-302047-vv5gpldi	32	16	for	for	IN
cord-302047-vv5gpldi	32	17	understanding	understanding	NN
cord-302047-vv5gpldi	32	18	and	and	CC
cord-302047-vv5gpldi	32	19	potentially	potentially	RB
cord-302047-vv5gpldi	32	20	predicting	predict	VBG
cord-302047-vv5gpldi	32	21	stability	stability	NN
cord-302047-vv5gpldi	32	22	.	.	.
cord-302047-vv5gpldi	33	1	We	-PRON-	PRP
cord-302047-vv5gpldi	33	2	identify	identify	VBP
cord-302047-vv5gpldi	33	3	theory	theory	NN
cord-302047-vv5gpldi	33	4	and	and	CC
cord-302047-vv5gpldi	33	5	experiments	experiment	NNS
cord-302047-vv5gpldi	33	6	that	that	WDT
cord-302047-vv5gpldi	33	7	point	point	VBP
cord-302047-vv5gpldi	33	8	toward	toward	IN
cord-302047-vv5gpldi	33	9	viable	viable	JJ
cord-302047-vv5gpldi	33	10	strategies	strategy	NNS
cord-302047-vv5gpldi	33	11	for	for	IN
cord-302047-vv5gpldi	33	12	mitigating	mitigate	VBG
cord-302047-vv5gpldi	33	13	the	the	DT
cord-302047-vv5gpldi	33	14	rapid	rapid	JJ
cord-302047-vv5gpldi	33	15	loss	loss	NN
cord-302047-vv5gpldi	33	16	of	of	IN
cord-302047-vv5gpldi	33	17	inserted	insert	VBN
cord-302047-vv5gpldi	33	18	genes	gene	NNS
cord-302047-vv5gpldi	33	19	,	,	,
cord-302047-vv5gpldi	33	20	and	and	CC
cord-302047-vv5gpldi	33	21	point	point	VB
cord-302047-vv5gpldi	33	22	out	out	RP
cord-302047-vv5gpldi	33	23	key	key	JJ
cord-302047-vv5gpldi	33	24	questions	question	NNS
cord-302047-vv5gpldi	33	25	that	that	WDT
cord-302047-vv5gpldi	33	26	should	should	MD
cord-302047-vv5gpldi	33	27	be	be	VB
cord-302047-vv5gpldi	33	28	addressed	address	VBN
cord-302047-vv5gpldi	33	29	in	in	IN
cord-302047-vv5gpldi	33	30	future	future	JJ
cord-302047-vv5gpldi	33	31	research	research	NN
cord-302047-vv5gpldi	33	32	.	.	.
cord-302047-vv5gpldi	34	1	We	-PRON-	PRP
cord-302047-vv5gpldi	34	2	argue	argue	VBP
cord-302047-vv5gpldi	34	3	that	that	IN
cord-302047-vv5gpldi	34	4	virus	virus	NN
cord-302047-vv5gpldi	34	5	genome	genome	NN
cord-302047-vv5gpldi	34	6	organization	organization	NN
cord-302047-vv5gpldi	34	7	has	have	VBZ
cord-302047-vv5gpldi	34	8	a	a	DT
cord-302047-vv5gpldi	34	9	large	large	JJ
cord-302047-vv5gpldi	34	10	impact	impact	NN
cord-302047-vv5gpldi	34	11	on	on	IN
cord-302047-vv5gpldi	34	12	the	the	DT
cord-302047-vv5gpldi	34	13	stability	stability	NN
cord-302047-vv5gpldi	34	14	of	of	IN
cord-302047-vv5gpldi	34	15	inserted	insert	VBN
cord-302047-vv5gpldi	34	16	sequences	sequence	NNS
cord-302047-vv5gpldi	34	17	,	,	,
cord-302047-vv5gpldi	34	18	whilst	whilst	IN
cord-302047-vv5gpldi	34	19	stability	stability	NN
cord-302047-vv5gpldi	34	20	is	be	VBZ
cord-302047-vv5gpldi	34	21	a	a	DT
cord-302047-vv5gpldi	34	22	complex	complex	JJ
cord-302047-vv5gpldi	34	23	trait	trait	NN
cord-302047-vv5gpldi	34	24	that	that	WDT
cord-302047-vv5gpldi	34	25	can	can	MD
cord-302047-vv5gpldi	34	26	depend	depend	VB
cord-302047-vv5gpldi	34	27	on	on	IN
cord-302047-vv5gpldi	34	28	environmental	environmental	JJ
cord-302047-vv5gpldi	34	29	conditions	condition	NNS
cord-302047-vv5gpldi	34	30	.	.	.
cord-302047-vv5gpldi	35	1	We	-PRON-	PRP
cord-302047-vv5gpldi	35	2	provide	provide	VBP
cord-302047-vv5gpldi	35	3	an	an	DT
cord-302047-vv5gpldi	35	4	overview	overview	NN
cord-302047-vv5gpldi	35	5	of	of	IN
cord-302047-vv5gpldi	35	6	empirical	empirical	JJ
cord-302047-vv5gpldi	35	7	results	result	NNS
cord-302047-vv5gpldi	35	8	for	for	IN
cord-302047-vv5gpldi	35	9	the	the	DT
cord-302047-vv5gpldi	35	10	stability	stability	NN
cord-302047-vv5gpldi	35	11	of	of	IN
cord-302047-vv5gpldi	35	12	natural	natural	JJ
cord-302047-vv5gpldi	35	13	and	and	CC
cord-302047-vv5gpldi	35	14	engineered	engineer	VBN
cord-302047-vv5gpldi	35	15	inserted	insert	VBN
cord-302047-vv5gpldi	35	16	sequences	sequence	NNS
cord-302047-vv5gpldi	35	17	,	,	,
cord-302047-vv5gpldi	35	18	following	follow	VBG
cord-302047-vv5gpldi	35	19	the	the	DT
cord-302047-vv5gpldi	35	20	Baltimore	Baltimore	NNP
cord-302047-vv5gpldi	35	21	classification	classification	NN
cord-302047-vv5gpldi	35	22	.	.	.
cord-302047-vv5gpldi	36	1	Our	-PRON-	PRP$
cord-302047-vv5gpldi	36	2	primary	primary	JJ
cord-302047-vv5gpldi	36	3	focus	focus	NN
cord-302047-vv5gpldi	36	4	is	be	VBZ
cord-302047-vv5gpldi	36	5	on	on	IN
cord-302047-vv5gpldi	36	6	engineered	engineer	VBN
cord-302047-vv5gpldi	36	7	viruses	virus	NNS
cord-302047-vv5gpldi	36	8	:	:	:
cord-302047-vv5gpldi	36	9	studies	study	NNS
cord-302047-vv5gpldi	36	10	where	where	WRB
cord-302047-vv5gpldi	36	11	gene	gene	NN
cord-302047-vv5gpldi	36	12	insertions	insertion	NNS
cord-302047-vv5gpldi	36	13	are	be	VBP
cord-302047-vv5gpldi	36	14	an	an	DT
cord-302047-vv5gpldi	36	15	addition	addition	NN
cord-302047-vv5gpldi	36	16	to	to	IN
cord-302047-vv5gpldi	36	17	the	the	DT
cord-302047-vv5gpldi	36	18	viral	viral	JJ
cord-302047-vv5gpldi	36	19	genome	genome	NN
cord-302047-vv5gpldi	36	20	(	(	-LRB-
cord-302047-vv5gpldi	36	21	leading	lead	VBG
cord-302047-vv5gpldi	36	22	to	to	IN
cord-302047-vv5gpldi	36	23	an	an	DT
cord-302047-vv5gpldi	36	24	increase	increase	NN
cord-302047-vv5gpldi	36	25	in	in	IN
cord-302047-vv5gpldi	36	26	genome	genome	NN
cord-302047-vv5gpldi	36	27	size	size	NN
cord-302047-vv5gpldi	36	28	)	)	-RRB-
cord-302047-vv5gpldi	36	29	and	and	CC
cord-302047-vv5gpldi	36	30	where	where	WRB
cord-302047-vv5gpldi	36	31	the	the	DT
cord-302047-vv5gpldi	36	32	subsequent	subsequent	JJ
cord-302047-vv5gpldi	36	33	fate	fate	NN
cord-302047-vv5gpldi	36	34	of	of	IN
cord-302047-vv5gpldi	36	35	these	these	DT
cord-302047-vv5gpldi	36	36	inserted	insert	VBN
cord-302047-vv5gpldi	36	37	sequences	sequence	NNS
cord-302047-vv5gpldi	36	38	has	have	VBZ
cord-302047-vv5gpldi	36	39	been	be	VBN
cord-302047-vv5gpldi	36	40	tracked	track	VBN
cord-302047-vv5gpldi	36	41	.	.	.
cord-302047-vv5gpldi	37	1	As	as	IN
cord-302047-vv5gpldi	37	2	inserted	insert	VBN
cord-302047-vv5gpldi	37	3	sequences	sequence	NNS
cord-302047-vv5gpldi	37	4	can	can	MD
cord-302047-vv5gpldi	37	5	incur	incur	VB
cord-302047-vv5gpldi	37	6	a	a	DT
cord-302047-vv5gpldi	37	7	fitness	fitness	NN
cord-302047-vv5gpldi	37	8	cost	cost	NN
cord-302047-vv5gpldi	37	9	,	,	,
cord-302047-vv5gpldi	37	10	these	these	DT
cord-302047-vv5gpldi	37	11	are	be	VBP
cord-302047-vv5gpldi	37	12	often	often	RB
cord-302047-vv5gpldi	37	13	quickly	quickly	RB
cord-302047-vv5gpldi	37	14	purged	purge	VBN
cord-302047-vv5gpldi	37	15	from	from	IN
cord-302047-vv5gpldi	37	16	the	the	DT
cord-302047-vv5gpldi	37	17	viral	viral	JJ
cord-302047-vv5gpldi	37	18	genome	genome	NN
cord-302047-vv5gpldi	37	19	.	.	.
cord-302047-vv5gpldi	38	1	Often	often	RB
cord-302047-vv5gpldi	38	2	these	these	DT
cord-302047-vv5gpldi	38	3	fitness	fitness	NN
cord-302047-vv5gpldi	38	4	costs	cost	NNS
cord-302047-vv5gpldi	38	5	are	be	VBP
cord-302047-vv5gpldi	38	6	related	relate	VBN
cord-302047-vv5gpldi	38	7	to	to	IN
cord-302047-vv5gpldi	38	8	a	a	DT
cord-302047-vv5gpldi	38	9	disruption	disruption	NN
cord-302047-vv5gpldi	38	10	of	of	IN
cord-302047-vv5gpldi	38	11	the	the	DT
cord-302047-vv5gpldi	38	12	viral	viral	JJ
cord-302047-vv5gpldi	38	13	genome	genome	NN
cord-302047-vv5gpldi	38	14	(	(	-LRB-
cord-302047-vv5gpldi	38	15	e.g.	e.g.	IN
cord-302047-vv5gpldi	38	16	gene	gene	NN
cord-302047-vv5gpldi	38	17	order	order	NN
cord-302047-vv5gpldi	38	18	)	)	-RRB-
cord-302047-vv5gpldi	38	19	.	.	.
cord-302047-vv5gpldi	39	1	We	-PRON-	PRP
cord-302047-vv5gpldi	39	2	therefore	therefore	RB
cord-302047-vv5gpldi	39	3	also	also	RB
cord-302047-vv5gpldi	39	4	consider	consider	VBP
cord-302047-vv5gpldi	39	5	studies	study	NNS
cord-302047-vv5gpldi	39	6	on	on	IN
cord-302047-vv5gpldi	39	7	genome	genome	NN
cord-302047-vv5gpldi	39	8	rearrangements	rearrangement	NNS
cord-302047-vv5gpldi	39	9	in	in	IN
cord-302047-vv5gpldi	39	10	wild	wild	JJ
cord-302047-vv5gpldi	39	11	viruses	virus	NNS
cord-302047-vv5gpldi	39	12	and	and	CC
cord-302047-vv5gpldi	39	13	introduce	introduce	VBP
cord-302047-vv5gpldi	39	14	other	other	JJ
cord-302047-vv5gpldi	39	15	relevant	relevant	JJ
cord-302047-vv5gpldi	39	16	modifications	modification	NNS
cord-302047-vv5gpldi	39	17	that	that	WDT
cord-302047-vv5gpldi	39	18	shed	shed	VBD
cord-302047-vv5gpldi	39	19	light	light	NN
cord-302047-vv5gpldi	39	20	on	on	IN
cord-302047-vv5gpldi	39	21	what	what	WP
cord-302047-vv5gpldi	39	22	the	the	DT
cord-302047-vv5gpldi	39	23	impact	impact	NN
cord-302047-vv5gpldi	39	24	of	of	IN
cord-302047-vv5gpldi	39	25	genomic	genomic	JJ
cord-302047-vv5gpldi	39	26	inserts	insert	NNS
cord-302047-vv5gpldi	39	27	can	can	MD
cord-302047-vv5gpldi	39	28	be	be	VB
cord-302047-vv5gpldi	39	29	.	.	.
cord-302047-vv5gpldi	40	1	We	-PRON-	PRP
cord-302047-vv5gpldi	40	2	provide	provide	VBP
cord-302047-vv5gpldi	40	3	an	an	DT
cord-302047-vv5gpldi	40	4	overview	overview	NN
cord-302047-vv5gpldi	40	5	of	of	IN
cord-302047-vv5gpldi	40	6	the	the	DT
cord-302047-vv5gpldi	40	7	results	result	NNS
cord-302047-vv5gpldi	40	8	and	and	CC
cord-302047-vv5gpldi	40	9	main	main	JJ
cord-302047-vv5gpldi	40	10	conclusions	conclusion	NNS
cord-302047-vv5gpldi	40	11	of	of	IN
cord-302047-vv5gpldi	40	12	our	-PRON-	PRP$
cord-302047-vv5gpldi	40	13	review	review	NN
cord-302047-vv5gpldi	40	14	in	in	IN
cord-302047-vv5gpldi	40	15	Table	Table	NNP
cord-302047-vv5gpldi	40	16	1	1	CD
cord-302047-vv5gpldi	40	17	.	.	.
cord-302047-vv5gpldi	41	1	Several	several	JJ
cord-302047-vv5gpldi	41	2	studies	study	NNS
cord-302047-vv5gpldi	41	3	relating	relate	VBG
cord-302047-vv5gpldi	41	4	to	to	IN
cord-302047-vv5gpldi	41	5	the	the	DT
cord-302047-vv5gpldi	41	6	stability	stability	NN
cord-302047-vv5gpldi	41	7	of	of	IN
cord-302047-vv5gpldi	41	8	double	double	RB
cord-302047-vv5gpldi	41	9	-	-	HYPH
cord-302047-vv5gpldi	41	10	stranded	stranded	JJ
cord-302047-vv5gpldi	41	11	(	(	-LRB-
cord-302047-vv5gpldi	41	12	ds	ds	NNP
cord-302047-vv5gpldi	41	13	)	)	-RRB-
cord-302047-vv5gpldi	41	14	DNA	dna	NN
cord-302047-vv5gpldi	41	15	viruses	virus	NNS
cord-302047-vv5gpldi	41	16	have	have	VBP
cord-302047-vv5gpldi	41	17	been	be	VBN
cord-302047-vv5gpldi	41	18	published	publish	VBN
cord-302047-vv5gpldi	41	19	.	.	.
cord-302047-vv5gpldi	42	1	The	the	DT
cord-302047-vv5gpldi	42	2	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	42	3	viruses	virus	NNS
cord-302047-vv5gpldi	42	4	have	have	VBP
cord-302047-vv5gpldi	42	5	a	a	DT
cord-302047-vv5gpldi	42	6	wide	wide	JJ
cord-302047-vv5gpldi	42	7	range	range	NN
cord-302047-vv5gpldi	42	8	of	of	IN
cord-302047-vv5gpldi	42	9	genome	genome	NN
cord-302047-vv5gpldi	42	10	sizes	size	NNS
cord-302047-vv5gpldi	42	11	,	,	,
cord-302047-vv5gpldi	42	12	from	from	IN
cord-302047-vv5gpldi	42	13	the	the	DT
cord-302047-vv5gpldi	42	14	small	small	JJ
cord-302047-vv5gpldi	42	15	Polyomaviridae	Polyomaviridae	NNP
cord-302047-vv5gpldi	42	16	and	and	CC
cord-302047-vv5gpldi	42	17	Papillomaviridae	Papillomaviridae	NNP
cord-302047-vv5gpldi	42	18	ranging	range	VBG
cord-302047-vv5gpldi	42	19	from	from	IN
cord-302047-vv5gpldi	42	20	4.5	4.5	CD
cord-302047-vv5gpldi	42	21	to	to	IN
cord-302047-vv5gpldi	42	22	8.4	8.4	CD
cord-302047-vv5gpldi	42	23	kbp	kbp	NNS
cord-302047-vv5gpldi	42	24	,	,	,
cord-302047-vv5gpldi	42	25	to	to	IN
cord-302047-vv5gpldi	42	26	the	the	DT
cord-302047-vv5gpldi	42	27	relatively	relatively	RB
cord-302047-vv5gpldi	42	28	Table	table	NN
cord-302047-vv5gpldi	42	29	1	1	CD
cord-302047-vv5gpldi	42	30	.	.	.
cord-302047-vv5gpldi	43	1	We	-PRON-	PRP
cord-302047-vv5gpldi	43	2	provide	provide	VBP
cord-302047-vv5gpldi	43	3	an	an	DT
cord-302047-vv5gpldi	43	4	overview	overview	NN
cord-302047-vv5gpldi	43	5	of	of	IN
cord-302047-vv5gpldi	43	6	the	the	DT
cord-302047-vv5gpldi	43	7	main	main	JJ
cord-302047-vv5gpldi	43	8	conclusions	conclusion	NNS
cord-302047-vv5gpldi	43	9	,	,	,
cord-302047-vv5gpldi	43	10	for	for	IN
cord-302047-vv5gpldi	43	11	all	all	DT
cord-302047-vv5gpldi	43	12	viruses	virus	NNS
cord-302047-vv5gpldi	43	13	and	and	CC
cord-302047-vv5gpldi	43	14	for	for	IN
cord-302047-vv5gpldi	43	15	the	the	DT
cord-302047-vv5gpldi	43	16	different	different	JJ
cord-302047-vv5gpldi	43	17	Baltimore	Baltimore	NNP
cord-302047-vv5gpldi	43	18	classification	classification	NN
cord-302047-vv5gpldi	43	19	groups	group	NNS
cord-302047-vv5gpldi	43	20	.	.	.
cord-302047-vv5gpldi	44	1	Viruses	virus	NNS
cord-302047-vv5gpldi	44	2	genera	genus	NNS
cord-302047-vv5gpldi	44	3	covered	cover	VBN
cord-302047-vv5gpldi	44	4	in	in	IN
cord-302047-vv5gpldi	44	5	relevant	relevant	JJ
cord-302047-vv5gpldi	44	6	studies	study	NNS
cord-302047-vv5gpldi	44	7	Conclusions	conclusion	NNS
cord-302047-vv5gpldi	44	8	of	of	IN
cord-302047-vv5gpldi	44	9	this	this	DT
cord-302047-vv5gpldi	44	10	review	review	NN
cord-302047-vv5gpldi	45	1	All	all	DT
cord-302047-vv5gpldi	45	2	viruses	virus	NNS
cord-302047-vv5gpldi	46	1	•	•	NNP
cord-302047-vv5gpldi	47	1	Inserted	insert	VBN
cord-302047-vv5gpldi	47	2	sequences	sequence	NNS
cord-302047-vv5gpldi	47	3	are	be	VBP
cord-302047-vv5gpldi	47	4	often	often	RB
cord-302047-vv5gpldi	47	5	unstable	unstable	JJ
cord-302047-vv5gpldi	47	6	and	and	CC
cord-302047-vv5gpldi	47	7	rapidly	rapidly	RB
cord-302047-vv5gpldi	47	8	lost	lose	VBN
cord-302047-vv5gpldi	47	9	upon	upon	IN
cord-302047-vv5gpldi	47	10	passaging	passaging	NN
cord-302047-vv5gpldi	47	11	of	of	IN
cord-302047-vv5gpldi	47	12	an	an	DT
cord-302047-vv5gpldi	47	13	engineered	engineer	VBN
cord-302047-vv5gpldi	47	14	virus	virus	NN
cord-302047-vv5gpldi	48	1	•	•	NNP
cord-302047-vv5gpldi	49	1	The	the	DT
cord-302047-vv5gpldi	49	2	position	position	NN
cord-302047-vv5gpldi	49	3	at	at	IN
cord-302047-vv5gpldi	49	4	which	which	WDT
cord-302047-vv5gpldi	49	5	a	a	DT
cord-302047-vv5gpldi	49	6	sequence	sequence	NN
cord-302047-vv5gpldi	49	7	is	be	VBZ
cord-302047-vv5gpldi	49	8	integrated	integrate	VBN
cord-302047-vv5gpldi	49	9	in	in	IN
cord-302047-vv5gpldi	49	10	the	the	DT
cord-302047-vv5gpldi	49	11	genome	genome	NN
cord-302047-vv5gpldi	49	12	can	can	MD
cord-302047-vv5gpldi	49	13	be	be	VB
cord-302047-vv5gpldi	49	14	important	important	JJ
cord-302047-vv5gpldi	49	15	for	for	IN
cord-302047-vv5gpldi	49	16	stability	stability	NN
cord-302047-vv5gpldi	50	1	•	•	NNP
cord-302047-vv5gpldi	51	1	Sequence	sequence	NN
cord-302047-vv5gpldi	51	2	stability	stability	NN
cord-302047-vv5gpldi	51	3	is	be	VBZ
cord-302047-vv5gpldi	51	4	not	not	RB
cord-302047-vv5gpldi	51	5	an	an	DT
cord-302047-vv5gpldi	51	6	intrinsic	intrinsic	JJ
cord-302047-vv5gpldi	51	7	property	property	NN
cord-302047-vv5gpldi	51	8	of	of	IN
cord-302047-vv5gpldi	51	9	genomes	genome	NNS
cord-302047-vv5gpldi	51	10	because	because	IN
cord-302047-vv5gpldi	51	11	demographic	demographic	JJ
cord-302047-vv5gpldi	51	12	parameters	parameter	NNS
cord-302047-vv5gpldi	51	13	,	,	,
cord-302047-vv5gpldi	51	14	such	such	JJ
cord-302047-vv5gpldi	51	15	as	as	IN
cord-302047-vv5gpldi	51	16	population	population	NN
cord-302047-vv5gpldi	51	17	size	size	NN
cord-302047-vv5gpldi	51	18	and	and	CC
cord-302047-vv5gpldi	51	19	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	51	20	size	size	NN
cord-302047-vv5gpldi	51	21	,	,	,
cord-302047-vv5gpldi	51	22	can	can	MD
cord-302047-vv5gpldi	51	23	have	have	VB
cord-302047-vv5gpldi	51	24	important	important	JJ
cord-302047-vv5gpldi	51	25	effects	effect	NNS
cord-302047-vv5gpldi	51	26	on	on	IN
cord-302047-vv5gpldi	51	27	sequence	sequence	NN
cord-302047-vv5gpldi	51	28	stability	stability	NN
cord-302047-vv5gpldi	52	1	•	•	NNP
cord-302047-vv5gpldi	53	1	The	the	DT
cord-302047-vv5gpldi	53	2	multiplicity	multiplicity	NN
cord-302047-vv5gpldi	53	3	of	of	IN
cord-302047-vv5gpldi	53	4	cellular	cellular	JJ
cord-302047-vv5gpldi	53	5	infection	infection	NN
cord-302047-vv5gpldi	53	6	affects	affect	VBZ
cord-302047-vv5gpldi	53	7	sequence	sequence	NN
cord-302047-vv5gpldi	53	8	stability	stability	NN
cord-302047-vv5gpldi	53	9	,	,	,
cord-302047-vv5gpldi	53	10	and	and	CC
cord-302047-vv5gpldi	53	11	can	can	MD
cord-302047-vv5gpldi	53	12	in	in	IN
cord-302047-vv5gpldi	53	13	some	some	DT
cord-302047-vv5gpldi	53	14	cases	case	NNS
cord-302047-vv5gpldi	53	15	directly	directly	RB
cord-302047-vv5gpldi	53	16	affect	affect	VBP
cord-302047-vv5gpldi	53	17	whether	whether	IN
cord-302047-vv5gpldi	53	18	there	there	EX
cord-302047-vv5gpldi	53	19	is	be	VBZ
cord-302047-vv5gpldi	53	20	selection	selection	NN
cord-302047-vv5gpldi	53	21	for	for	IN
cord-302047-vv5gpldi	53	22	deletion	deletion	NN
cord-302047-vv5gpldi	53	23	variants	variant	NNS
cord-302047-vv5gpldi	54	1	•	•	NNP
cord-302047-vv5gpldi	55	1	Deletions	deletion	NNS
cord-302047-vv5gpldi	55	2	are	be	VBP
cord-302047-vv5gpldi	55	3	not	not	RB
cord-302047-vv5gpldi	55	4	the	the	DT
cord-302047-vv5gpldi	55	5	only	only	JJ
cord-302047-vv5gpldi	55	6	class	class	NN
cord-302047-vv5gpldi	55	7	of	of	IN
cord-302047-vv5gpldi	55	8	mutations	mutation	NNS
cord-302047-vv5gpldi	55	9	that	that	WDT
cord-302047-vv5gpldi	55	10	can	can	MD
cord-302047-vv5gpldi	55	11	reduce	reduce	VB
cord-302047-vv5gpldi	55	12	the	the	DT
cord-302047-vv5gpldi	55	13	cost	cost	NN
cord-302047-vv5gpldi	55	14	of	of	IN
cord-302047-vv5gpldi	55	15	inserted	insert	VBN
cord-302047-vv5gpldi	55	16	sequences	sequence	NNS
cord-302047-vv5gpldi	55	17	,	,	,
cord-302047-vv5gpldi	55	18	although	although	IN
cord-302047-vv5gpldi	55	19	they	-PRON-	PRP
cord-302047-vv5gpldi	55	20	are	be	VBP
cord-302047-vv5gpldi	55	21	the	the	DT
cord-302047-vv5gpldi	55	22	most	most	RBS
cord-302047-vv5gpldi	55	23	common	common	JJ
cord-302047-vv5gpldi	55	24	I	i	NN
cord-302047-vv5gpldi	55	25	:	:	:
cord-302047-vv5gpldi	55	26	dsDNA	dsdna	RB
cord-302047-vv5gpldi	56	1	Alphabaculovirus	Alphabaculovirus	NNP
cord-302047-vv5gpldi	56	2	,	,	,
cord-302047-vv5gpldi	56	3	Lambdavirus	Lambdavirus	NNP
cord-302047-vv5gpldi	56	4	,	,	,
cord-302047-vv5gpldi	56	5	Mastadenovirus	Mastadenovirus	NNP
cord-302047-vv5gpldi	56	6	,	,	,
cord-302047-vv5gpldi	56	7	Orthopoxvirus	Orthopoxvirus	NNP
cord-302047-vv5gpldi	56	8	,	,	,
cord-302047-vv5gpldi	56	9	T7likevirus	T7likevirus	NNP
cord-302047-vv5gpldi	56	10	,	,	,
cord-302047-vv5gpldi	56	11	Varicellovirus	Varicellovirus	NNP
cord-302047-vv5gpldi	56	12	•	•	NNP
cord-302047-vv5gpldi	56	13	Large	large	JJ
cord-302047-vv5gpldi	56	14	genomes	genome	NNS
cord-302047-vv5gpldi	56	15	that	that	WDT
cord-302047-vv5gpldi	56	16	are	be	VBP
cord-302047-vv5gpldi	56	17	readily	readily	RB
cord-302047-vv5gpldi	56	18	engineered	engineer	VBN
cord-302047-vv5gpldi	56	19	and	and	CC
cord-302047-vv5gpldi	56	20	also	also	RB
cord-302047-vv5gpldi	56	21	highly	highly	RB
cord-302047-vv5gpldi	56	22	plastic	plastic	JJ
cord-302047-vv5gpldi	56	23	,	,	,
cord-302047-vv5gpldi	56	24	as	as	IN
cord-302047-vv5gpldi	56	25	exemplified	exemplify	VBN
cord-302047-vv5gpldi	56	26	by	by	IN
cord-302047-vv5gpldi	56	27	the	the	DT
cord-302047-vv5gpldi	56	28	'	'	``
cord-302047-vv5gpldi	56	29	genome	genome	NN
cord-302047-vv5gpldi	56	30	accordion	accordion	NN
cord-302047-vv5gpldi	56	31	'	'	''
cord-302047-vv5gpldi	56	32	in	in	IN
cord-302047-vv5gpldi	56	33	poxviruses	poxvirus	NNS
cord-302047-vv5gpldi	57	1	•	•	NNP
cord-302047-vv5gpldi	58	1	Small	small	JJ
cord-302047-vv5gpldi	58	2	insertions	insertion	NNS
cord-302047-vv5gpldi	58	3	can	can	MD
cord-302047-vv5gpldi	58	4	be	be	VB
cord-302047-vv5gpldi	58	5	stable	stable	JJ
cord-302047-vv5gpldi	58	6	,	,	,
cord-302047-vv5gpldi	58	7	but	but	CC
cord-302047-vv5gpldi	58	8	larger	large	JJR
cord-302047-vv5gpldi	58	9	insertion	insertion	NN
cord-302047-vv5gpldi	58	10	are	be	VBP
cord-302047-vv5gpldi	58	11	rapidly	rapidly	RB
cord-302047-vv5gpldi	58	12	lost	lose	VBN
cord-302047-vv5gpldi	58	13	•	•	NN
cord-302047-vv5gpldi	59	1	Classic	classic	JJ
cord-302047-vv5gpldi	59	2	studies	study	NNS
cord-302047-vv5gpldi	59	3	with	with	IN
cord-302047-vv5gpldi	59	4	phages	phage	NNS
cord-302047-vv5gpldi	59	5	exemplify	exemplify	VBP
cord-302047-vv5gpldi	59	6	how	how	WRB
cord-302047-vv5gpldi	59	7	lower	low	JJR
cord-302047-vv5gpldi	59	8	limits	limit	NNS
cord-302047-vv5gpldi	59	9	to	to	IN
cord-302047-vv5gpldi	59	10	the	the	DT
cord-302047-vv5gpldi	59	11	size	size	NN
cord-302047-vv5gpldi	59	12	of	of	IN
cord-302047-vv5gpldi	59	13	packaged	package	VBN
cord-302047-vv5gpldi	59	14	genomes	genome	NNS
cord-302047-vv5gpldi	59	15	can	can	MD
cord-302047-vv5gpldi	59	16	be	be	VB
cord-302047-vv5gpldi	59	17	used	use	VBN
cord-302047-vv5gpldi	59	18	to	to	TO
cord-302047-vv5gpldi	59	19	increase	increase	VB
cord-302047-vv5gpldi	59	20	insertion	insertion	NN
cord-302047-vv5gpldi	59	21	stability	stability	NN
cord-302047-vv5gpldi	59	22	II	ii	CD
cord-302047-vv5gpldi	59	23	:	:	:
cord-302047-vv5gpldi	60	1	The	the	DT
cord-302047-vv5gpldi	60	2	inverted	inverted	JJ
cord-302047-vv5gpldi	60	3	terminal	terminal	NN
cord-302047-vv5gpldi	60	4	repeats	repeat	NNS
cord-302047-vv5gpldi	60	5	of	of	IN
cord-302047-vv5gpldi	60	6	vaccinia	vaccinia	NN
cord-302047-vv5gpldi	60	7	virus	virus	NN
cord-302047-vv5gpldi	60	8	undergo	undergo	VBP
cord-302047-vv5gpldi	60	9	rapid	rapid	JJ
cord-302047-vv5gpldi	60	10	changes	change	NNS
cord-302047-vv5gpldi	60	11	in	in	IN
cord-302047-vv5gpldi	60	12	size	size	NN
cord-302047-vv5gpldi	60	13	due	due	IN
cord-302047-vv5gpldi	60	14	to	to	IN
cord-302047-vv5gpldi	60	15	unequal	unequal	JJ
cord-302047-vv5gpldi	60	16	crossover	crossover	NN
cord-302047-vv5gpldi	60	17	events	event	NNS
cord-302047-vv5gpldi	60	18	leading	lead	VBG
cord-302047-vv5gpldi	60	19	to	to	IN
cord-302047-vv5gpldi	60	20	stable	stable	JJ
cord-302047-vv5gpldi	60	21	and	and	CC
cord-302047-vv5gpldi	60	22	unstable	unstable	JJ
cord-302047-vv5gpldi	60	23	forms	form	NNS
cord-302047-vv5gpldi	60	24	(	(	-LRB-
cord-302047-vv5gpldi	60	25	Moss	Moss	NNP
cord-302047-vv5gpldi	60	26	,	,	,
cord-302047-vv5gpldi	60	27	Winters	Winters	NNPS
cord-302047-vv5gpldi	60	28	,	,	,
cord-302047-vv5gpldi	60	29	and	and	CC
cord-302047-vv5gpldi	60	30	Cooper	Cooper	NNP
cord-302047-vv5gpldi	60	31	1981	1981	CD
cord-302047-vv5gpldi	60	32	)	)	-RRB-
cord-302047-vv5gpldi	60	33	.	.	.
cord-302047-vv5gpldi	61	1	The	the	DT
cord-302047-vv5gpldi	61	2	diversity	diversity	NN
cord-302047-vv5gpldi	61	3	in	in	IN
cord-302047-vv5gpldi	61	4	this	this	DT
cord-302047-vv5gpldi	61	5	region	region	NN
cord-302047-vv5gpldi	61	6	is	be	VBZ
cord-302047-vv5gpldi	61	7	needed	need	VBN
cord-302047-vv5gpldi	61	8	for	for	IN
cord-302047-vv5gpldi	61	9	immune	immune	JJ
cord-302047-vv5gpldi	61	10	evasion	evasion	NN
cord-302047-vv5gpldi	61	11	and	and	CC
cord-302047-vv5gpldi	61	12	for	for	IN
cord-302047-vv5gpldi	61	13	the	the	DT
cord-302047-vv5gpldi	61	14	colonization	colonization	NN
cord-302047-vv5gpldi	61	15	of	of	IN
cord-302047-vv5gpldi	61	16	novel	novel	JJ
cord-302047-vv5gpldi	61	17	hosts	host	NNS
cord-302047-vv5gpldi	61	18	and	and	CC
cord-302047-vv5gpldi	61	19	appears	appear	VBZ
cord-302047-vv5gpldi	61	20	to	to	TO
cord-302047-vv5gpldi	61	21	be	be	VB
cord-302047-vv5gpldi	61	22	mainly	mainly	RB
cord-302047-vv5gpldi	61	23	regulated	regulate	VBN
cord-302047-vv5gpldi	61	24	by	by	IN
cord-302047-vv5gpldi	61	25	recombination	recombination	NN
cord-302047-vv5gpldi	61	26	events	event	NNS
cord-302047-vv5gpldi	61	27	.	.	.
cord-302047-vv5gpldi	62	1	However	however	RB
cord-302047-vv5gpldi	62	2	,	,	,
cord-302047-vv5gpldi	62	3	other	other	JJ
cord-302047-vv5gpldi	62	4	processes	process	NNS
cord-302047-vv5gpldi	62	5	such	such	JJ
cord-302047-vv5gpldi	62	6	as	as	IN
cord-302047-vv5gpldi	62	7	mutation	mutation	NN
cord-302047-vv5gpldi	62	8	leading	lead	VBG
cord-302047-vv5gpldi	62	9	to	to	IN
cord-302047-vv5gpldi	62	10	accelerated	accelerated	JJ
cord-302047-vv5gpldi	62	11	rates	rate	NNS
cord-302047-vv5gpldi	62	12	of	of	IN
cord-302047-vv5gpldi	62	13	recombination	recombination	NN
cord-302047-vv5gpldi	62	14	can	can	MD
cord-302047-vv5gpldi	62	15	not	not	RB
cord-302047-vv5gpldi	62	16	be	be	VB
cord-302047-vv5gpldi	62	17	ruled	rule	VBN
cord-302047-vv5gpldi	62	18	out	out	RP
cord-302047-vv5gpldi	62	19	.	.	.
cord-302047-vv5gpldi	63	1	Poxviruses	poxvirus	NNS
cord-302047-vv5gpldi	63	2	,	,	,
cord-302047-vv5gpldi	63	3	such	such	JJ
cord-302047-vv5gpldi	63	4	as	as	IN
cord-302047-vv5gpldi	63	5	vaccinia	vaccinia	NN
cord-302047-vv5gpldi	63	6	,	,	,
cord-302047-vv5gpldi	63	7	virus	virus	NN
cord-302047-vv5gpldi	63	8	are	be	VBP
cord-302047-vv5gpldi	63	9	classified	classify	VBN
cord-302047-vv5gpldi	63	10	as	as	IN
cord-302047-vv5gpldi	63	11	nucleocytoplasmic	nucleocytoplasmic	JJ
cord-302047-vv5gpldi	63	12	large	large	JJ
cord-302047-vv5gpldi	63	13	DNA	dna	NN
cord-302047-vv5gpldi	63	14	viruses	virus	NNS
cord-302047-vv5gpldi	63	15	(	(	-LRB-
cord-302047-vv5gpldi	63	16	NCLDVs	ncldv	NNS
cord-302047-vv5gpldi	63	17	)	)	-RRB-
cord-302047-vv5gpldi	63	18	.	.	.
cord-302047-vv5gpldi	64	1	These	these	DT
cord-302047-vv5gpldi	64	2	viruses	virus	NNS
cord-302047-vv5gpldi	64	3	have	have	VBP
cord-302047-vv5gpldi	64	4	larger	large	JJR
cord-302047-vv5gpldi	64	5	than	than	IN
cord-302047-vv5gpldi	64	6	average	average	JJ
cord-302047-vv5gpldi	64	7	genome	genome	NN
cord-302047-vv5gpldi	64	8	sizes	size	NNS
cord-302047-vv5gpldi	64	9	and	and	CC
cord-302047-vv5gpldi	64	10	the	the	DT
cord-302047-vv5gpldi	64	11	more	more	RBR
cord-302047-vv5gpldi	64	12	recently	recently	RB
cord-302047-vv5gpldi	64	13	discovered	discover	VBN
cord-302047-vv5gpldi	64	14	giant	giant	JJ
cord-302047-vv5gpldi	64	15	viruses	virus	NNS
cord-302047-vv5gpldi	64	16	are	be	VBP
cord-302047-vv5gpldi	64	17	also	also	RB
cord-302047-vv5gpldi	64	18	classified	classify	VBN
cord-302047-vv5gpldi	64	19	as	as	IN
cord-302047-vv5gpldi	64	20	such	such	JJ
cord-302047-vv5gpldi	64	21	.	.	.
cord-302047-vv5gpldi	65	1	The	the	DT
cord-302047-vv5gpldi	65	2	NCLDVs	ncldv	NNS
cord-302047-vv5gpldi	65	3	appear	appear	VBP
cord-302047-vv5gpldi	65	4	to	to	TO
cord-302047-vv5gpldi	65	5	have	have	VB
cord-302047-vv5gpldi	65	6	undergone	undergo	VBN
cord-302047-vv5gpldi	65	7	a	a	DT
cord-302047-vv5gpldi	65	8	dynamic	dynamic	JJ
cord-302047-vv5gpldi	65	9	evolution	evolution	NN
cord-302047-vv5gpldi	65	10	where	where	WRB
cord-302047-vv5gpldi	65	11	gene	gene	NN
cord-302047-vv5gpldi	65	12	gain	gain	NN
cord-302047-vv5gpldi	65	13	and	and	CC
cord-302047-vv5gpldi	65	14	loss	loss	NN
cord-302047-vv5gpldi	65	15	events	event	NNS
cord-302047-vv5gpldi	65	16	go	go	VBP
cord-302047-vv5gpldi	65	17	in	in	IN
cord-302047-vv5gpldi	65	18	parallel	parallel	NN
cord-302047-vv5gpldi	65	19	with	with	IN
cord-302047-vv5gpldi	65	20	host	host	NN
cord-302047-vv5gpldi	65	21	-	-	HYPH
cord-302047-vv5gpldi	65	22	switches	switch	NNS
cord-302047-vv5gpldi	65	23	between	between	IN
cord-302047-vv5gpldi	65	24	animal	animal	NN
cord-302047-vv5gpldi	65	25	and	and	CC
cord-302047-vv5gpldi	65	26	protist	protist	NN
cord-302047-vv5gpldi	65	27	hosts	host	NNS
cord-302047-vv5gpldi	65	28	(	(	-LRB-
cord-302047-vv5gpldi	65	29	Koonin	Koonin	NNP
cord-302047-vv5gpldi	65	30	and	and	CC
cord-302047-vv5gpldi	65	31	Yutin	Yutin	NNP
cord-302047-vv5gpldi	65	32	2018	2018	CD
cord-302047-vv5gpldi	65	33	)	)	-RRB-
cord-302047-vv5gpldi	65	34	.	.	.
cord-302047-vv5gpldi	66	1	Interestingly	interestingly	RB
cord-302047-vv5gpldi	66	2	,	,	,
cord-302047-vv5gpldi	66	3	the	the	DT
cord-302047-vv5gpldi	66	4	phylogenomic	phylogenomic	NNP
cord-302047-vv5gpldi	66	5	reconstructions	reconstruction	NNS
cord-302047-vv5gpldi	66	6	performed	perform	VBN
cord-302047-vv5gpldi	66	7	by	by	IN
cord-302047-vv5gpldi	66	8	Koonin	Koonin	NNP
cord-302047-vv5gpldi	66	9	and	and	CC
cord-302047-vv5gpldi	66	10	Yutin	Yutin	NNP
cord-302047-vv5gpldi	66	11	(	(	-LRB-
cord-302047-vv5gpldi	66	12	2018	2018	CD
cord-302047-vv5gpldi	66	13	)	)	-RRB-
cord-302047-vv5gpldi	66	14	suggest	suggest	VBP
cord-302047-vv5gpldi	66	15	that	that	IN
cord-302047-vv5gpldi	66	16	giant	giant	JJ
cord-302047-vv5gpldi	66	17	viruses	virus	NNS
cord-302047-vv5gpldi	66	18	(	(	-LRB-
cord-302047-vv5gpldi	66	19	for	for	IN
cord-302047-vv5gpldi	66	20	which	which	WDT
cord-302047-vv5gpldi	66	21	the	the	DT
cord-302047-vv5gpldi	66	22	host	host	NN
cord-302047-vv5gpldi	66	23	range	range	NN
cord-302047-vv5gpldi	66	24	appears	appear	VBZ
cord-302047-vv5gpldi	66	25	to	to	TO
cord-302047-vv5gpldi	66	26	be	be	VB
cord-302047-vv5gpldi	66	27	restricted	restrict	VBN
cord-302047-vv5gpldi	66	28	to	to	IN
cord-302047-vv5gpldi	66	29	protists	protist	NNS
cord-302047-vv5gpldi	66	30	)	)	-RRB-
cord-302047-vv5gpldi	66	31	have	have	VBP
cord-302047-vv5gpldi	66	32	evolved	evolve	VBN
cord-302047-vv5gpldi	66	33	from	from	IN
cord-302047-vv5gpldi	66	34	simpler	simple	JJR
cord-302047-vv5gpldi	66	35	viruses	virus	NNS
cord-302047-vv5gpldi	66	36	(	(	-LRB-
cord-302047-vv5gpldi	66	37	infecting	infect	VBG
cord-302047-vv5gpldi	66	38	animals	animal	NNS
cord-302047-vv5gpldi	66	39	)	)	-RRB-
cord-302047-vv5gpldi	66	40	on	on	IN
cord-302047-vv5gpldi	66	41	many	many	JJ
cord-302047-vv5gpldi	66	42	independent	independent	JJ
cord-302047-vv5gpldi	66	43	occasions	occasion	NNS
cord-302047-vv5gpldi	66	44	.	.	.
cord-302047-vv5gpldi	67	1	This	this	DT
cord-302047-vv5gpldi	67	2	again	again	RB
cord-302047-vv5gpldi	67	3	suggests	suggest	VBZ
cord-302047-vv5gpldi	67	4	that	that	IN
cord-302047-vv5gpldi	67	5	the	the	DT
cord-302047-vv5gpldi	67	6	host	host	NN
cord-302047-vv5gpldi	67	7	plays	play	VBZ
cord-302047-vv5gpldi	67	8	an	an	DT
cord-302047-vv5gpldi	67	9	important	important	JJ
cord-302047-vv5gpldi	67	10	role	role	NN
cord-302047-vv5gpldi	67	11	in	in	IN
cord-302047-vv5gpldi	67	12	genome	genome	NN
cord-302047-vv5gpldi	67	13	stability	stability	NN
cord-302047-vv5gpldi	67	14	where	where	WRB
cord-302047-vv5gpldi	67	15	in	in	IN
cord-302047-vv5gpldi	67	16	animals	animal	NNS
cord-302047-vv5gpldi	67	17	the	the	DT
cord-302047-vv5gpldi	67	18	pressure	pressure	NN
cord-302047-vv5gpldi	67	19	for	for	IN
cord-302047-vv5gpldi	67	20	smaller	small	JJR
cord-302047-vv5gpldi	67	21	virus	virus	NN
cord-302047-vv5gpldi	67	22	genomes	genome	NNS
cord-302047-vv5gpldi	67	23	is	be	VBZ
cord-302047-vv5gpldi	67	24	stronger	strong	JJR
cord-302047-vv5gpldi	67	25	than	than	IN
cord-302047-vv5gpldi	67	26	in	in	IN
cord-302047-vv5gpldi	67	27	protists	protist	NNS
cord-302047-vv5gpldi	67	28	(	(	-LRB-
cord-302047-vv5gpldi	67	29	Koonin	Koonin	NNP
cord-302047-vv5gpldi	67	30	and	and	CC
cord-302047-vv5gpldi	67	31	Yutin	Yutin	NNP
cord-302047-vv5gpldi	67	32	2018	2018	CD
cord-302047-vv5gpldi	67	33	)	)	-RRB-
cord-302047-vv5gpldi	67	34	.	.	.
cord-302047-vv5gpldi	68	1	Experimentally	experimentally	RB
cord-302047-vv5gpldi	68	2	it	-PRON-	PRP
cord-302047-vv5gpldi	68	3	has	have	VBZ
cord-302047-vv5gpldi	68	4	also	also	RB
cord-302047-vv5gpldi	68	5	been	be	VBN
cord-302047-vv5gpldi	68	6	shown	show	VBN
cord-302047-vv5gpldi	68	7	that	that	IN
cord-302047-vv5gpldi	68	8	vaccinia	vaccinia	NN
cord-302047-vv5gpldi	68	9	virus	virus	NN
cord-302047-vv5gpldi	68	10	has	have	VBZ
cord-302047-vv5gpldi	68	11	a	a	DT
cord-302047-vv5gpldi	68	12	highly	highly	RB
cord-302047-vv5gpldi	68	13	plastic	plastic	JJ
cord-302047-vv5gpldi	68	14	genome	genome	NN
cord-302047-vv5gpldi	68	15	.	.	.
cord-302047-vv5gpldi	69	1	After	after	IN
cord-302047-vv5gpldi	69	2	deletion	deletion	NN
cord-302047-vv5gpldi	69	3	of	of	IN
cord-302047-vv5gpldi	69	4	one	one	CD
cord-302047-vv5gpldi	69	5	host	host	NN
cord-302047-vv5gpldi	69	6	range	range	NN
cord-302047-vv5gpldi	69	7	gene	gene	NN
cord-302047-vv5gpldi	69	8	of	of	IN
cord-302047-vv5gpldi	69	9	vaccinia	vaccinia	NN
cord-302047-vv5gpldi	69	10	virus	virus	NN
cord-302047-vv5gpldi	69	11	,	,	,
cord-302047-vv5gpldi	69	12	another	another	DT
cord-302047-vv5gpldi	69	13	host	host	NN
cord-302047-vv5gpldi	69	14	range	range	NN
cord-302047-vv5gpldi	69	15	gene	gene	NN
cord-302047-vv5gpldi	69	16	increases	increase	NNS
cord-302047-vv5gpldi	69	17	in	in	IN
cord-302047-vv5gpldi	69	18	copy	copy	NN
cord-302047-vv5gpldi	69	19	number	number	NN
cord-302047-vv5gpldi	70	1	(	(	-LRB-
cord-302047-vv5gpldi	70	2	Elde	Elde	NNP
cord-302047-vv5gpldi	70	3	et	et	NNP
cord-302047-vv5gpldi	70	4	al	al	NNP
cord-302047-vv5gpldi	70	5	.	.	.
cord-302047-vv5gpldi	70	6	2012	2012	CD
cord-302047-vv5gpldi	70	7	)	)	-RRB-
cord-302047-vv5gpldi	70	8	,	,	,
cord-302047-vv5gpldi	70	9	leading	lead	VBG
cord-302047-vv5gpldi	70	10	to	to	IN
cord-302047-vv5gpldi	70	11	genomic	genomic	JJ
cord-302047-vv5gpldi	70	12	expansion	expansion	NN
cord-302047-vv5gpldi	70	13	.	.	.
cord-302047-vv5gpldi	71	1	The	the	DT
cord-302047-vv5gpldi	71	2	increased	increase	VBN
cord-302047-vv5gpldi	71	3	gene	gene	NN
cord-302047-vv5gpldi	71	4	expression	expression	NN
cord-302047-vv5gpldi	71	5	is	be	VBZ
cord-302047-vv5gpldi	71	6	in	in	IN
cord-302047-vv5gpldi	71	7	itself	-PRON-	PRP
cord-302047-vv5gpldi	71	8	beneficial	beneficial	JJ
cord-302047-vv5gpldi	71	9	,	,	,
cord-302047-vv5gpldi	71	10	but	but	CC
cord-302047-vv5gpldi	71	11	the	the	DT
cord-302047-vv5gpldi	71	12	high	high	JJ
cord-302047-vv5gpldi	71	13	gene	gene	NN
cord-302047-vv5gpldi	71	14	copy	copy	NN
cord-302047-vv5gpldi	71	15	number	number	NN
cord-302047-vv5gpldi	71	16	also	also	RB
cord-302047-vv5gpldi	71	17	increases	increase	VBZ
cord-302047-vv5gpldi	71	18	the	the	DT
cord-302047-vv5gpldi	71	19	supply	supply	NN
cord-302047-vv5gpldi	71	20	of	of	IN
cord-302047-vv5gpldi	71	21	beneficial	beneficial	JJ
cord-302047-vv5gpldi	71	22	gain	gain	NN
cord-302047-vv5gpldi	71	23	-	-	HYPH
cord-302047-vv5gpldi	71	24	offunction	offunction	NN
cord-302047-vv5gpldi	71	25	mutations	mutation	NNS
cord-302047-vv5gpldi	71	26	.	.	.
cord-302047-vv5gpldi	72	1	Once	once	IN
cord-302047-vv5gpldi	72	2	these	these	DT
cord-302047-vv5gpldi	72	3	gain	gain	VB
cord-302047-vv5gpldi	72	4	-	-	HYPH
cord-302047-vv5gpldi	72	5	of	of	IN
cord-302047-vv5gpldi	72	6	-	-	HYPH
cord-302047-vv5gpldi	72	7	function	function	NN
cord-302047-vv5gpldi	72	8	mutations	mutation	NNS
cord-302047-vv5gpldi	72	9	are	be	VBP
cord-302047-vv5gpldi	72	10	fixed	fix	VBN
cord-302047-vv5gpldi	72	11	in	in	IN
cord-302047-vv5gpldi	72	12	the	the	DT
cord-302047-vv5gpldi	72	13	population	population	NN
cord-302047-vv5gpldi	72	14	,	,	,
cord-302047-vv5gpldi	72	15	the	the	DT
cord-302047-vv5gpldi	72	16	other	other	JJ
cord-302047-vv5gpldi	72	17	copies	copy	NNS
cord-302047-vv5gpldi	72	18	of	of	IN
cord-302047-vv5gpldi	72	19	the	the	DT
cord-302047-vv5gpldi	72	20	gene	gene	NN
cord-302047-vv5gpldi	72	21	are	be	VBP
cord-302047-vv5gpldi	72	22	lost	lose	VBN
cord-302047-vv5gpldi	72	23	and	and	CC
cord-302047-vv5gpldi	72	24	thus	thus	RB
cord-302047-vv5gpldi	72	25	the	the	DT
cord-302047-vv5gpldi	72	26	vaccinia	vaccinia	NN
cord-302047-vv5gpldi	72	27	genome	genome	NN
cord-302047-vv5gpldi	72	28	size	size	NN
cord-302047-vv5gpldi	72	29	decreased	decrease	VBD
cord-302047-vv5gpldi	72	30	(	(	-LRB-
cord-302047-vv5gpldi	72	31	associated	associate	VBN
cord-302047-vv5gpldi	72	32	with	with	IN
cord-302047-vv5gpldi	72	33	the	the	DT
cord-302047-vv5gpldi	72	34	cost	cost	NN
cord-302047-vv5gpldi	72	35	of	of	IN
cord-302047-vv5gpldi	72	36	an	an	DT
cord-302047-vv5gpldi	72	37	increased	increase	VBN
cord-302047-vv5gpldi	72	38	genome	genome	NN
cord-302047-vv5gpldi	72	39	size	size	NN
cord-302047-vv5gpldi	72	40	)	)	-RRB-
cord-302047-vv5gpldi	73	1	(	(	-LRB-
cord-302047-vv5gpldi	73	2	Elde	Elde	NNP
cord-302047-vv5gpldi	73	3	et	et	NNP
cord-302047-vv5gpldi	73	4	al	al	NNP
cord-302047-vv5gpldi	73	5	.	.	.
cord-302047-vv5gpldi	73	6	2012	2012	CD
cord-302047-vv5gpldi	73	7	)	)	-RRB-
cord-302047-vv5gpldi	73	8	,	,	,
cord-302047-vv5gpldi	73	9	leading	lead	VBG
cord-302047-vv5gpldi	73	10	to	to	IN
cord-302047-vv5gpldi	73	11	accordion	accordion	NN
cord-302047-vv5gpldi	73	12	-	-	HYPH
cord-302047-vv5gpldi	73	13	like	like	JJ
cord-302047-vv5gpldi	73	14	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	73	15	dynamics	dynamic	NNS
cord-302047-vv5gpldi	73	16	(	(	-LRB-
cord-302047-vv5gpldi	73	17	Andersson	Andersson	NNP
cord-302047-vv5gpldi	73	18	,	,	,
cord-302047-vv5gpldi	73	19	Slechta	Slechta	NNP
cord-302047-vv5gpldi	73	20	,	,	,
cord-302047-vv5gpldi	73	21	and	and	CC
cord-302047-vv5gpldi	73	22	Roth	Roth	NNP
cord-302047-vv5gpldi	73	23	1998	1998	CD
cord-302047-vv5gpldi	73	24	)	)	-RRB-
cord-302047-vv5gpldi	73	25	.	.	.
cord-302047-vv5gpldi	74	1	Modified	modified	JJ
cord-302047-vv5gpldi	74	2	vaccinia	vaccinia	NN
cord-302047-vv5gpldi	74	3	virus	virus	NN
cord-302047-vv5gpldi	74	4	Ankara	Ankara	NNP
cord-302047-vv5gpldi	74	5	(	(	-LRB-
cord-302047-vv5gpldi	74	6	MVA	MVA	NNP
cord-302047-vv5gpldi	74	7	)	)	-RRB-
cord-302047-vv5gpldi	74	8	is	be	VBZ
cord-302047-vv5gpldi	74	9	used	use	VBN
cord-302047-vv5gpldi	74	10	as	as	IN
cord-302047-vv5gpldi	74	11	a	a	DT
cord-302047-vv5gpldi	74	12	viral	viral	JJ
cord-302047-vv5gpldi	74	13	vector	vector	NN
cord-302047-vv5gpldi	74	14	for	for	IN
cord-302047-vv5gpldi	74	15	the	the	DT
cord-302047-vv5gpldi	74	16	development	development	NN
cord-302047-vv5gpldi	74	17	of	of	IN
cord-302047-vv5gpldi	74	18	vaccines	vaccine	NNS
cord-302047-vv5gpldi	74	19	against	against	IN
cord-302047-vv5gpldi	74	20	infectious	infectious	JJ
cord-302047-vv5gpldi	74	21	diseases	disease	NNS
cord-302047-vv5gpldi	74	22	such	such	JJ
cord-302047-vv5gpldi	74	23	as	as	IN
cord-302047-vv5gpldi	74	24	malaria	malaria	NN
cord-302047-vv5gpldi	74	25	,	,	,
cord-302047-vv5gpldi	74	26	influenza	influenza	NN
cord-302047-vv5gpldi	74	27	,	,	,
cord-302047-vv5gpldi	74	28	tuberculosis	tuberculosis	NN
cord-302047-vv5gpldi	74	29	,	,	,
cord-302047-vv5gpldi	74	30	HIV	HIV	NNP
cord-302047-vv5gpldi	74	31	/	/	SYM
cord-302047-vv5gpldi	74	32	AIDs	AIDs	NNP
cord-302047-vv5gpldi	74	33	,	,	,
cord-302047-vv5gpldi	74	34	and	and	CC
cord-302047-vv5gpldi	74	35	Ebola	Ebola	NNP
cord-302047-vv5gpldi	74	36	(	(	-LRB-
cord-302047-vv5gpldi	74	37	Sutter	Sutter	NNP
cord-302047-vv5gpldi	74	38	and	and	CC
cord-302047-vv5gpldi	74	39	Staib	Staib	NNP
cord-302047-vv5gpldi	74	40	2003	2003	CD
cord-302047-vv5gpldi	74	41	;	;	:
cord-302047-vv5gpldi	75	1	Gó	Gó	NNP
cord-302047-vv5gpldi	75	2	mez	mez	NNP
cord-302047-vv5gpldi	75	3	et	et	NNP
cord-302047-vv5gpldi	75	4	al	al	NNP
cord-302047-vv5gpldi	75	5	.	.	.
cord-302047-vv5gpldi	76	1	2012	2012	CD
cord-302047-vv5gpldi	76	2	;	;	:
cord-302047-vv5gpldi	76	3	Gilbert	Gilbert	NNP
cord-302047-vv5gpldi	76	4	2013	2013	CD
cord-302047-vv5gpldi	76	5	;	;	:
cord-302047-vv5gpldi	76	6	Stanley	Stanley	NNP
cord-302047-vv5gpldi	76	7	et	et	NNP
cord-302047-vv5gpldi	76	8	al	al	NNP
cord-302047-vv5gpldi	76	9	.	.	.
cord-302047-vv5gpldi	77	1	2014	2014	LS
cord-302047-vv5gpldi	77	2	)	)	-RRB-
cord-302047-vv5gpldi	78	1	The	the	DT
cord-302047-vv5gpldi	78	2	optimization	optimization	NN
cord-302047-vv5gpldi	78	3	of	of	IN
cord-302047-vv5gpldi	78	4	poxvirus	poxvirus	NNP
cord-302047-vv5gpldi	78	5	promoters	promoter	NNS
cord-302047-vv5gpldi	78	6	in	in	IN
cord-302047-vv5gpldi	78	7	this	this	DT
cord-302047-vv5gpldi	78	8	viral	viral	JJ
cord-302047-vv5gpldi	78	9	vector	vector	NN
cord-302047-vv5gpldi	78	10	has	have	VBZ
cord-302047-vv5gpldi	78	11	proven	prove	VBN
cord-302047-vv5gpldi	78	12	to	to	TO
cord-302047-vv5gpldi	78	13	be	be	VB
cord-302047-vv5gpldi	78	14	an	an	DT
cord-302047-vv5gpldi	78	15	effective	effective	JJ
cord-302047-vv5gpldi	78	16	strategy	strategy	NN
cord-302047-vv5gpldi	78	17	for	for	IN
cord-302047-vv5gpldi	78	18	increasing	increase	VBG
cord-302047-vv5gpldi	78	19	the	the	DT
cord-302047-vv5gpldi	78	20	stability	stability	NN
cord-302047-vv5gpldi	78	21	of	of	IN
cord-302047-vv5gpldi	78	22	antigen	antigen	NN
cord-302047-vv5gpldi	78	23	(	(	-LRB-
cord-302047-vv5gpldi	78	24	inserted	insert	VBN
cord-302047-vv5gpldi	78	25	sequence	sequence	NN
cord-302047-vv5gpldi	78	26	)	)	-RRB-
cord-302047-vv5gpldi	78	27	expression	expression	NN
cord-302047-vv5gpldi	78	28	,	,	,
cord-302047-vv5gpldi	78	29	and	and	CC
cord-302047-vv5gpldi	78	30	therewith	therewith	IN
cord-302047-vv5gpldi	78	31	the	the	DT
cord-302047-vv5gpldi	78	32	development	development	NN
cord-302047-vv5gpldi	78	33	of	of	IN
cord-302047-vv5gpldi	78	34	MVA	MVA	NNP
cord-302047-vv5gpldi	78	35	-	-	HYPH
cord-302047-vv5gpldi	78	36	based	base	VBN
cord-302047-vv5gpldi	78	37	vaccines	vaccine	NNS
cord-302047-vv5gpldi	78	38	(	(	-LRB-
cord-302047-vv5gpldi	78	39	Alharbi	Alharbi	NNP
cord-302047-vv5gpldi	78	40	2019	2019	CD
cord-302047-vv5gpldi	78	41	)	)	-RRB-
cord-302047-vv5gpldi	78	42	.	.	.
cord-302047-vv5gpldi	79	1	Although	although	IN
cord-302047-vv5gpldi	79	2	live	live	JJ
cord-302047-vv5gpldi	79	3	attenuated	attenuated	JJ
cord-302047-vv5gpldi	79	4	vaccines	vaccine	NNS
cord-302047-vv5gpldi	79	5	have	have	VBP
cord-302047-vv5gpldi	79	6	substantially	substantially	RB
cord-302047-vv5gpldi	79	7	reduced	reduce	VBN
cord-302047-vv5gpldi	79	8	rabies	rabies	NN
cord-302047-vv5gpldi	79	9	prevalence	prevalence	NN
cord-302047-vv5gpldi	79	10	after	after	IN
cord-302047-vv5gpldi	79	11	oral	oral	JJ
cord-302047-vv5gpldi	79	12	-	-	HYPH
cord-302047-vv5gpldi	79	13	vaccination	vaccination	NN
cord-302047-vv5gpldi	79	14	campaigns	campaign	NNS
cord-302047-vv5gpldi	79	15	were	be	VBD
cord-302047-vv5gpldi	79	16	conducted	conduct	VBN
cord-302047-vv5gpldi	80	1	(	(	-LRB-
cord-302047-vv5gpldi	80	2	Lafay	Lafay	NNP
cord-302047-vv5gpldi	80	3	et	et	NNP
cord-302047-vv5gpldi	80	4	al	al	NNP
cord-302047-vv5gpldi	80	5	.	.	.
cord-302047-vv5gpldi	80	6	1994	1994	CD
cord-302047-vv5gpldi	81	1	;	;	:
cord-302047-vv5gpldi	81	2	MacInnes	MacInnes	NNP
cord-302047-vv5gpldi	81	3	et	et	NNP
cord-302047-vv5gpldi	81	4	al	al	NNP
cord-302047-vv5gpldi	81	5	.	.	NNP
cord-302047-vv5gpldi	81	6	2001	2001	CD
cord-302047-vv5gpldi	81	7	)	)	-RRB-
cord-302047-vv5gpldi	81	8	,	,	,
cord-302047-vv5gpldi	81	9	such	such	JJ
cord-302047-vv5gpldi	81	10	live	live	JJ
cord-302047-vv5gpldi	81	11	vaccines	vaccine	NNS
cord-302047-vv5gpldi	81	12	are	be	VBP
cord-302047-vv5gpldi	81	13	not	not	RB
cord-302047-vv5gpldi	81	14	efficacious	efficacious	JJ
cord-302047-vv5gpldi	81	15	in	in	IN
cord-302047-vv5gpldi	81	16	all	all	DT
cord-302047-vv5gpldi	81	17	rabies	rabies	NN
cord-302047-vv5gpldi	81	18	vector	vector	NN
cord-302047-vv5gpldi	81	19	species	specie	NNS
cord-302047-vv5gpldi	81	20	.	.	.
cord-302047-vv5gpldi	82	1	As	as	IN
cord-302047-vv5gpldi	82	2	an	an	DT
cord-302047-vv5gpldi	82	3	alternative	alternative	NN
cord-302047-vv5gpldi	82	4	,	,	,
cord-302047-vv5gpldi	82	5	recombinant	recombinant	JJ
cord-302047-vv5gpldi	82	6	human	human	JJ
cord-302047-vv5gpldi	82	7	adenovirus	adenovirus	NN
cord-302047-vv5gpldi	82	8	vaccine	vaccine	NN
cord-302047-vv5gpldi	82	9	vectors	vector	NNS
cord-302047-vv5gpldi	82	10	expressing	express	VBG
cord-302047-vv5gpldi	82	11	the	the	DT
cord-302047-vv5gpldi	82	12	rabies	rabies	NN
cord-302047-vv5gpldi	82	13	glycoprotein	glycoprotein	NN
cord-302047-vv5gpldi	82	14	have	have	VBP
cord-302047-vv5gpldi	82	15	been	be	VBN
cord-302047-vv5gpldi	82	16	developed	develop	VBN
cord-302047-vv5gpldi	82	17	.	.	.
cord-302047-vv5gpldi	83	1	The	the	DT
cord-302047-vv5gpldi	83	2	fitness	fitness	NN
cord-302047-vv5gpldi	83	3	of	of	IN
cord-302047-vv5gpldi	83	4	a	a	DT
cord-302047-vv5gpldi	83	5	replication	replication	NN
cord-302047-vv5gpldi	83	6	-	-	HYPH
cord-302047-vv5gpldi	83	7	competent	competent	JJ
cord-302047-vv5gpldi	83	8	human	human	JJ
cord-302047-vv5gpldi	83	9	adenovirus	adenovirus	NN
cord-302047-vv5gpldi	83	10	expressing	express	VBG
cord-302047-vv5gpldi	83	11	the	the	DT
cord-302047-vv5gpldi	83	12	rabies	rabies	NN
cord-302047-vv5gpldi	83	13	glycoprotein	glycoprotein	NN
cord-302047-vv5gpldi	83	14	was	be	VBD
cord-302047-vv5gpldi	83	15	similar	similar	JJ
cord-302047-vv5gpldi	83	16	to	to	IN
cord-302047-vv5gpldi	83	17	that	that	DT
cord-302047-vv5gpldi	83	18	of	of	IN
cord-302047-vv5gpldi	83	19	the	the	DT
cord-302047-vv5gpldi	83	20	wild	wild	JJ
cord-302047-vv5gpldi	83	21	-	-	HYPH
cord-302047-vv5gpldi	83	22	type	type	NN
cord-302047-vv5gpldi	83	23	virus	virus	NN
cord-302047-vv5gpldi	83	24	,	,	,
cord-302047-vv5gpldi	83	25	as	as	IN
cord-302047-vv5gpldi	83	26	tested	test	VBN
cord-302047-vv5gpldi	83	27	in	in	IN
cord-302047-vv5gpldi	83	28	vitro	vitro	FW
cord-302047-vv5gpldi	83	29	(	(	-LRB-
cord-302047-vv5gpldi	83	30	Knowles	Knowles	NNP
cord-302047-vv5gpldi	83	31	et	et	NNP
cord-302047-vv5gpldi	83	32	al	al	NNP
cord-302047-vv5gpldi	83	33	.	.	.
cord-302047-vv5gpldi	83	34	2009	2009	CD
cord-302047-vv5gpldi	83	35	)	)	-RRB-
cord-302047-vv5gpldi	83	36	.	.	.
cord-302047-vv5gpldi	84	1	Moreover	moreover	RB
cord-302047-vv5gpldi	84	2	,	,	,
cord-302047-vv5gpldi	84	3	the	the	DT
cord-302047-vv5gpldi	84	4	inserted	insert	VBN
cord-302047-vv5gpldi	84	5	rabies	rabies	NNP
cord-302047-vv5gpldi	84	6	virus	virus	NN
cord-302047-vv5gpldi	84	7	gene	gene	NN
cord-302047-vv5gpldi	84	8	was	be	VBD
cord-302047-vv5gpldi	84	9	stable	stable	JJ
cord-302047-vv5gpldi	84	10	during	during	IN
cord-302047-vv5gpldi	84	11	both	both	DT
cord-302047-vv5gpldi	84	12	in	in	IN
cord-302047-vv5gpldi	84	13	vivo	vivo	NN
cord-302047-vv5gpldi	84	14	and	and	CC
cord-302047-vv5gpldi	84	15	in	in	IN
cord-302047-vv5gpldi	84	16	vitro	vitro	FW
cord-302047-vv5gpldi	84	17	passaging	passaging	NN
cord-302047-vv5gpldi	85	1	(	(	-LRB-
cord-302047-vv5gpldi	85	2	Knowles	Knowles	NNP
cord-302047-vv5gpldi	85	3	et	et	NNP
cord-302047-vv5gpldi	85	4	al	al	NNP
cord-302047-vv5gpldi	85	5	.	.	.
cord-302047-vv5gpldi	85	6	2009	2009	CD
cord-302047-vv5gpldi	85	7	)	)	-RRB-
cord-302047-vv5gpldi	85	8	,	,	,
cord-302047-vv5gpldi	85	9	demonstrating	demonstrate	VBG
cord-302047-vv5gpldi	85	10	the	the	DT
cord-302047-vv5gpldi	85	11	potential	potential	NN
cord-302047-vv5gpldi	85	12	of	of	IN
cord-302047-vv5gpldi	85	13	this	this	DT
cord-302047-vv5gpldi	85	14	recombinant	recombinant	JJ
cord-302047-vv5gpldi	85	15	vaccine	vaccine	NN
cord-302047-vv5gpldi	85	16	vector	vector	NN
cord-302047-vv5gpldi	85	17	as	as	IN
cord-302047-vv5gpldi	85	18	an	an	DT
cord-302047-vv5gpldi	85	19	effective	effective	JJ
cord-302047-vv5gpldi	85	20	alternative	alternative	NN
cord-302047-vv5gpldi	85	21	.	.	.
cord-302047-vv5gpldi	86	1	Non	non	JJ
cord-302047-vv5gpldi	86	2	-	-	JJ
cord-302047-vv5gpldi	86	3	human	human	JJ
cord-302047-vv5gpldi	86	4	adenoviruses	adenovirus	NNS
cord-302047-vv5gpldi	86	5	can	can	MD
cord-302047-vv5gpldi	86	6	be	be	VB
cord-302047-vv5gpldi	86	7	used	use	VBN
cord-302047-vv5gpldi	86	8	as	as	IN
cord-302047-vv5gpldi	86	9	alternative	alternative	JJ
cord-302047-vv5gpldi	86	10	vaccine	vaccine	NN
cord-302047-vv5gpldi	86	11	vectors	vector	NNS
cord-302047-vv5gpldi	86	12	,	,	,
cord-302047-vv5gpldi	86	13	providing	provide	VBG
cord-302047-vv5gpldi	86	14	several	several	JJ
cord-302047-vv5gpldi	86	15	advantages	advantage	NNS
cord-302047-vv5gpldi	86	16	such	such	JJ
cord-302047-vv5gpldi	86	17	as	as	IN
cord-302047-vv5gpldi	86	18	a	a	DT
cord-302047-vv5gpldi	86	19	limited	limited	JJ
cord-302047-vv5gpldi	86	20	host	host	NN
cord-302047-vv5gpldi	86	21	range	range	NN
cord-302047-vv5gpldi	86	22	and	and	CC
cord-302047-vv5gpldi	86	23	restricted	restricted	JJ
cord-302047-vv5gpldi	86	24	replication	replication	NN
cord-302047-vv5gpldi	86	25	in	in	IN
cord-302047-vv5gpldi	86	26	non	non	JJ
cord-302047-vv5gpldi	86	27	-	-	JJ
cord-302047-vv5gpldi	86	28	host	host	JJ
cord-302047-vv5gpldi	86	29	species	specie	NNS
cord-302047-vv5gpldi	86	30	.	.	.
cord-302047-vv5gpldi	87	1	By	by	IN
cord-302047-vv5gpldi	87	2	using	use	VBG
cord-302047-vv5gpldi	87	3	bovine	bovine	JJ
cord-302047-vv5gpldi	87	4	adenovirus	adenovirus	NN
cord-302047-vv5gpldi	87	5	type	type	NN
cord-302047-vv5gpldi	87	6	3	3	CD
cord-302047-vv5gpldi	87	7	,	,	,
cord-302047-vv5gpldi	87	8	a	a	DT
cord-302047-vv5gpldi	87	9	variety	variety	NN
cord-302047-vv5gpldi	87	10	of	of	IN
cord-302047-vv5gpldi	87	11	antigens	antigen	NNS
cord-302047-vv5gpldi	87	12	and	and	CC
cord-302047-vv5gpldi	87	13	cytokines	cytokine	NNS
cord-302047-vv5gpldi	87	14	were	be	VBD
cord-302047-vv5gpldi	87	15	successfully	successfully	RB
cord-302047-vv5gpldi	87	16	expressed	express	VBN
cord-302047-vv5gpldi	87	17	in	in	IN
cord-302047-vv5gpldi	87	18	vivo	vivo	NN
cord-302047-vv5gpldi	88	1	(	(	-LRB-
cord-302047-vv5gpldi	88	2	Ayalew	Ayalew	NNP
cord-302047-vv5gpldi	88	3	et	et	NNP
cord-302047-vv5gpldi	88	4	al	al	NNP
cord-302047-vv5gpldi	88	5	.	.	NNP
cord-302047-vv5gpldi	88	6	2015	2015	CD
cord-302047-vv5gpldi	88	7	)	)	-RRB-
cord-302047-vv5gpldi	88	8	.	.	.
cord-302047-vv5gpldi	89	1	The	the	DT
cord-302047-vv5gpldi	89	2	stability	stability	NN
cord-302047-vv5gpldi	89	3	of	of	IN
cord-302047-vv5gpldi	89	4	bovine	bovine	JJ
cord-302047-vv5gpldi	89	5	adenovirus	adenovirus	NN
cord-302047-vv5gpldi	89	6	type	type	NN
cord-302047-vv5gpldi	89	7	1	1	CD
cord-302047-vv5gpldi	89	8	was	be	VBD
cord-302047-vv5gpldi	89	9	tested	test	VBN
cord-302047-vv5gpldi	89	10	by	by	IN
cord-302047-vv5gpldi	89	11	inserting	insert	VBG
cord-302047-vv5gpldi	89	12	the	the	DT
cord-302047-vv5gpldi	89	13	EYFP	EYFP	NNP
cord-302047-vv5gpldi	89	14	marker	marker	NN
cord-302047-vv5gpldi	89	15	and	and	CC
cord-302047-vv5gpldi	89	16	subsequently	subsequently	RB
cord-302047-vv5gpldi	89	17	passaging	passage	VBG
cord-302047-vv5gpldi	89	18	the	the	DT
cord-302047-vv5gpldi	89	19	recombinant	recombinant	JJ
cord-302047-vv5gpldi	89	20	virus	virus	NN
cord-302047-vv5gpldi	89	21	in	in	IN
cord-302047-vv5gpldi	89	22	cell	cell	NN
cord-302047-vv5gpldi	89	23	culture	culture	NN
cord-302047-vv5gpldi	90	1	(	(	-LRB-
cord-302047-vv5gpldi	90	2	Ren	Ren	NNP
cord-302047-vv5gpldi	90	3	et	et	NNP
cord-302047-vv5gpldi	90	4	al	al	NNP
cord-302047-vv5gpldi	90	5	.	.	.
cord-302047-vv5gpldi	90	6	2018	2018	CD
cord-302047-vv5gpldi	90	7	)	)	-RRB-
cord-302047-vv5gpldi	90	8	.	.	.
cord-302047-vv5gpldi	91	1	Although	although	IN
cord-302047-vv5gpldi	91	2	replication	replication	NN
cord-302047-vv5gpldi	91	3	of	of	IN
cord-302047-vv5gpldi	91	4	this	this	DT
cord-302047-vv5gpldi	91	5	recombinant	recombinant	JJ
cord-302047-vv5gpldi	91	6	virus	virus	NN
cord-302047-vv5gpldi	91	7	was	be	VBD
cord-302047-vv5gpldi	91	8	less	less	RBR
cord-302047-vv5gpldi	91	9	efficient	efficient	JJ
cord-302047-vv5gpldi	91	10	than	than	IN
cord-302047-vv5gpldi	91	11	the	the	DT
cord-302047-vv5gpldi	91	12	wild	wild	JJ
cord-302047-vv5gpldi	91	13	-	-	HYPH
cord-302047-vv5gpldi	91	14	type	type	NN
cord-302047-vv5gpldi	91	15	virus	virus	NN
cord-302047-vv5gpldi	91	16	,	,	,
cord-302047-vv5gpldi	91	17	the	the	DT
cord-302047-vv5gpldi	91	18	inserted	insert	VBN
cord-302047-vv5gpldi	91	19	EYFP	EYFP	NNP
cord-302047-vv5gpldi	91	20	was	be	VBD
cord-302047-vv5gpldi	91	21	stable	stable	JJ
cord-302047-vv5gpldi	91	22	.	.	.
cord-302047-vv5gpldi	92	1	Engineered	engineer	VBN
cord-302047-vv5gpldi	92	2	alphabaculoviruses	alphabaculoviruse	NNS
cord-302047-vv5gpldi	92	3	(	(	-LRB-
cord-302047-vv5gpldi	92	4	infecting	infect	VBG
cord-302047-vv5gpldi	92	5	arthropods	arthropod	NNS
cord-302047-vv5gpldi	92	6	)	)	-RRB-
cord-302047-vv5gpldi	92	7	are	be	VBP
cord-302047-vv5gpldi	92	8	widely	widely	RB
cord-302047-vv5gpldi	92	9	used	use	VBN
cord-302047-vv5gpldi	92	10	as	as	IN
cord-302047-vv5gpldi	92	11	vectors	vector	NNS
cord-302047-vv5gpldi	92	12	for	for	IN
cord-302047-vv5gpldi	92	13	the	the	DT
cord-302047-vv5gpldi	92	14	expression	expression	NN
cord-302047-vv5gpldi	92	15	of	of	IN
cord-302047-vv5gpldi	92	16	heterologous	heterologous	JJ
cord-302047-vv5gpldi	92	17	genes	gene	NNS
cord-302047-vv5gpldi	92	18	in	in	IN
cord-302047-vv5gpldi	92	19	insect	insect	NN
cord-302047-vv5gpldi	92	20	cells	cell	NNS
cord-302047-vv5gpldi	92	21	.	.	.
cord-302047-vv5gpldi	93	1	Nonetheless	nonetheless	RB
cord-302047-vv5gpldi	93	2	,	,	,
cord-302047-vv5gpldi	93	3	during	during	IN
cord-302047-vv5gpldi	93	4	serial	serial	JJ
cord-302047-vv5gpldi	93	5	passaging	passaging	NN
cord-302047-vv5gpldi	93	6	defective	defective	JJ
cord-302047-vv5gpldi	93	7	interfering	interfere	VBG
cord-302047-vv5gpldi	93	8	(	(	-LRB-
cord-302047-vv5gpldi	93	9	DI	DI	NNP
cord-302047-vv5gpldi	93	10	)	)	-RRB-
cord-302047-vv5gpldi	93	11	baculoviruses	baculoviruse	NNS
cord-302047-vv5gpldi	93	12	that	that	WDT
cord-302047-vv5gpldi	93	13	lack	lack	VBP
cord-302047-vv5gpldi	93	14	large	large	JJ
cord-302047-vv5gpldi	93	15	portions	portion	NNS
cord-302047-vv5gpldi	93	16	of	of	IN
cord-302047-vv5gpldi	93	17	the	the	DT
cord-302047-vv5gpldi	93	18	genome	genome	NN
cord-302047-vv5gpldi	93	19	are	be	VBP
cord-302047-vv5gpldi	93	20	rapidly	rapidly	RB
cord-302047-vv5gpldi	93	21	produced	produce	VBN
cord-302047-vv5gpldi	93	22	,	,	,
cord-302047-vv5gpldi	93	23	in	in	IN
cord-302047-vv5gpldi	93	24	what	what	WP
cord-302047-vv5gpldi	93	25	appears	appear	VBZ
cord-302047-vv5gpldi	93	26	to	to	TO
cord-302047-vv5gpldi	93	27	be	be	VB
cord-302047-vv5gpldi	93	28	an	an	DT
cord-302047-vv5gpldi	93	29	intrinsic	intrinsic	JJ
cord-302047-vv5gpldi	93	30	property	property	NN
cord-302047-vv5gpldi	93	31	of	of	IN
cord-302047-vv5gpldi	93	32	baculovirus	baculovirus	FW
cord-302047-vv5gpldi	93	33	infection	infection	NN
cord-302047-vv5gpldi	94	1	(	(	-LRB-
cord-302047-vv5gpldi	94	2	Pijlman	Pijlman	NNP
cord-302047-vv5gpldi	94	3	et	et	FW
cord-302047-vv5gpldi	94	4	al	al	NNP
cord-302047-vv5gpldi	94	5	.	.	NNP
cord-302047-vv5gpldi	94	6	2001	2001	CD
cord-302047-vv5gpldi	94	7	)	)	-RRB-
cord-302047-vv5gpldi	94	8	.	.	.
cord-302047-vv5gpldi	95	1	As	as	IN
cord-302047-vv5gpldi	95	2	a	a	DT
cord-302047-vv5gpldi	95	3	result	result	NN
cord-302047-vv5gpldi	95	4	of	of	IN
cord-302047-vv5gpldi	95	5	having	have	VBG
cord-302047-vv5gpldi	95	6	a	a	DT
cord-302047-vv5gpldi	95	7	smaller	small	JJR
cord-302047-vv5gpldi	95	8	genome	genome	NN
cord-302047-vv5gpldi	95	9	size	size	NN
cord-302047-vv5gpldi	95	10	,	,	,
cord-302047-vv5gpldi	95	11	these	these	DT
cord-302047-vv5gpldi	95	12	DIs	dis	VBP
cord-302047-vv5gpldi	95	13	most	most	RBS
cord-302047-vv5gpldi	95	14	likely	likely	RB
cord-302047-vv5gpldi	95	15	have	have	VB
cord-302047-vv5gpldi	95	16	a	a	DT
cord-302047-vv5gpldi	95	17	replicative	replicative	JJ
cord-302047-vv5gpldi	95	18	advantage	advantage	NN
cord-302047-vv5gpldi	95	19	(	(	-LRB-
cord-302047-vv5gpldi	95	20	higher	high	JJR
cord-302047-vv5gpldi	95	21	fitness	fitness	NN
cord-302047-vv5gpldi	95	22	)	)	-RRB-
cord-302047-vv5gpldi	95	23	.	.	.
cord-302047-vv5gpldi	96	1	Especially	especially	RB
cord-302047-vv5gpldi	96	2	in	in	IN
cord-302047-vv5gpldi	96	3	bioreactor	bioreactor	NN
cord-302047-vv5gpldi	96	4	configurations	configuration	NNS
cord-302047-vv5gpldi	96	5	where	where	WRB
cord-302047-vv5gpldi	96	6	the	the	DT
cord-302047-vv5gpldi	96	7	cellular	cellular	JJ
cord-302047-vv5gpldi	96	8	multiplicity	multiplicity	NN
cord-302047-vv5gpldi	96	9	of	of	IN
cord-302047-vv5gpldi	96	10	infection	infection	NN
cord-302047-vv5gpldi	96	11	(	(	-LRB-
cord-302047-vv5gpldi	96	12	MOI	MOI	NNP
cord-302047-vv5gpldi	96	13	,	,	,
cord-302047-vv5gpldi	96	14	the	the	DT
cord-302047-vv5gpldi	96	15	number	number	NN
cord-302047-vv5gpldi	96	16	of	of	IN
cord-302047-vv5gpldi	96	17	virus	virus	NN
cord-302047-vv5gpldi	96	18	particles	particle	NNS
cord-302047-vv5gpldi	96	19	infecting	infect	VBG
cord-302047-vv5gpldi	96	20	a	a	DT
cord-302047-vv5gpldi	96	21	cell	cell	NN
cord-302047-vv5gpldi	96	22	)	)	-RRB-
cord-302047-vv5gpldi	96	23	is	be	VBZ
cord-302047-vv5gpldi	96	24	high	high	JJ
cord-302047-vv5gpldi	96	25	,	,	,
cord-302047-vv5gpldi	96	26	fasterreplicating	fasterreplicate	VBG
cord-302047-vv5gpldi	96	27	DIs	dis	NN
cord-302047-vv5gpldi	96	28	can	can	MD
cord-302047-vv5gpldi	96	29	rapidly	rapidly	RB
cord-302047-vv5gpldi	96	30	reach	reach	VB
cord-302047-vv5gpldi	96	31	high	high	JJ
cord-302047-vv5gpldi	96	32	frequencies	frequency	NNS
cord-302047-vv5gpldi	97	1	(	(	-LRB-
cord-302047-vv5gpldi	97	2	Kool	Kool	NNP
cord-302047-vv5gpldi	97	3	et	et	NNP
cord-302047-vv5gpldi	97	4	al	al	NNP
cord-302047-vv5gpldi	97	5	.	.	NNP
cord-302047-vv5gpldi	97	6	1991	1991	CD
cord-302047-vv5gpldi	97	7	)	)	-RRB-
cord-302047-vv5gpldi	97	8	.	.	.
cord-302047-vv5gpldi	98	1	The	the	DT
cord-302047-vv5gpldi	98	2	rapid	rapid	JJ
cord-302047-vv5gpldi	98	3	generation	generation	NN
cord-302047-vv5gpldi	98	4	of	of	IN
cord-302047-vv5gpldi	98	5	DIs	dis	NN
cord-302047-vv5gpldi	98	6	involves	involve	VBZ
cord-302047-vv5gpldi	98	7	several	several	JJ
cord-302047-vv5gpldi	98	8	recombination	recombination	NN
cord-302047-vv5gpldi	98	9	steps	step	NNS
cord-302047-vv5gpldi	98	10	and	and	CC
cord-302047-vv5gpldi	98	11	prevents	prevent	VBZ
cord-302047-vv5gpldi	98	12	the	the	DT
cord-302047-vv5gpldi	98	13	development	development	NN
cord-302047-vv5gpldi	98	14	of	of	IN
cord-302047-vv5gpldi	98	15	stable	stable	JJ
cord-302047-vv5gpldi	98	16	baculovirus	baculovirus	NNP
cord-302047-vv5gpldi	98	17	expression	expression	NN
cord-302047-vv5gpldi	98	18	vectors	vector	NNS
cord-302047-vv5gpldi	98	19	,	,	,
cord-302047-vv5gpldi	98	20	as	as	IN
cord-302047-vv5gpldi	98	21	inserted	insert	VBN
cord-302047-vv5gpldi	98	22	sequences	sequence	NNS
cord-302047-vv5gpldi	98	23	are	be	VBP
cord-302047-vv5gpldi	98	24	then	then	RB
cord-302047-vv5gpldi	98	25	also	also	RB
cord-302047-vv5gpldi	98	26	rapidly	rapidly	RB
cord-302047-vv5gpldi	98	27	lost	lose	VBD
cord-302047-vv5gpldi	99	1	(	(	-LRB-
cord-302047-vv5gpldi	99	2	Pijlman	Pijlman	NNP
cord-302047-vv5gpldi	99	3	et	et	FW
cord-302047-vv5gpldi	99	4	al	al	NNP
cord-302047-vv5gpldi	99	5	.	.	NNP
cord-302047-vv5gpldi	99	6	2001	2001	CD
cord-302047-vv5gpldi	99	7	)	)	-RRB-
cord-302047-vv5gpldi	99	8	.	.	.
cord-302047-vv5gpldi	100	1	The	the	DT
cord-302047-vv5gpldi	100	2	loss	loss	NN
cord-302047-vv5gpldi	100	3	of	of	IN
cord-302047-vv5gpldi	100	4	sequences	sequence	NNS
cord-302047-vv5gpldi	100	5	inserted	insert	VBN
cord-302047-vv5gpldi	100	6	into	into	IN
cord-302047-vv5gpldi	100	7	baculovirus	baculovirus	NNP
cord-302047-vv5gpldi	100	8	genomes	genome	NNS
cord-302047-vv5gpldi	100	9	is	be	VBZ
cord-302047-vv5gpldi	100	10	not	not	RB
cord-302047-vv5gpldi	100	11	only	only	RB
cord-302047-vv5gpldi	100	12	due	due	IN
cord-302047-vv5gpldi	100	13	to	to	IN
cord-302047-vv5gpldi	100	14	the	the	DT
cord-302047-vv5gpldi	100	15	formation	formation	NN
cord-302047-vv5gpldi	100	16	of	of	IN
cord-302047-vv5gpldi	100	17	DIs	dis	NN
cord-302047-vv5gpldi	100	18	.	.	.
cord-302047-vv5gpldi	101	1	When	when	WRB
cord-302047-vv5gpldi	101	2	an	an	DT
cord-302047-vv5gpldi	101	3	origin	origin	NN
cord-302047-vv5gpldi	101	4	of	of	IN
cord-302047-vv5gpldi	101	5	replication	replication	NN
cord-302047-vv5gpldi	101	6	that	that	WDT
cord-302047-vv5gpldi	101	7	is	be	VBZ
cord-302047-vv5gpldi	101	8	enriched	enrich	VBN
cord-302047-vv5gpldi	101	9	in	in	IN
cord-302047-vv5gpldi	101	10	DI	DI	NNP
cord-302047-vv5gpldi	101	11	genomes	genome	NNS
cord-302047-vv5gpldi	101	12	was	be	VBD
cord-302047-vv5gpldi	101	13	removed	remove	VBN
cord-302047-vv5gpldi	101	14	,	,	,
cord-302047-vv5gpldi	101	15	baculovirus	baculovirus	NNP
cord-302047-vv5gpldi	101	16	genomic	genomic	JJ
cord-302047-vv5gpldi	101	17	stability	stability	NN
cord-302047-vv5gpldi	101	18	at	at	IN
cord-302047-vv5gpldi	101	19	high	high	JJ
cord-302047-vv5gpldi	101	20	MOIs	mois	NN
cord-302047-vv5gpldi	101	21	increased	increase	VBD
cord-302047-vv5gpldi	101	22	as	as	IN
cord-302047-vv5gpldi	101	23	no	no	DT
cord-302047-vv5gpldi	101	24	DIs	dis	NN
cord-302047-vv5gpldi	101	25	were	be	VBD
cord-302047-vv5gpldi	101	26	observed	observe	VBN
cord-302047-vv5gpldi	101	27	.	.	.
cord-302047-vv5gpldi	102	1	Strikingly	strikingly	RB
cord-302047-vv5gpldi	102	2	,	,	,
cord-302047-vv5gpldi	102	3	inserted	insert	VBN
cord-302047-vv5gpldi	102	4	foreign	foreign	JJ
cord-302047-vv5gpldi	102	5	sequences	sequence	NNS
cord-302047-vv5gpldi	102	6	were	be	VBD
cord-302047-vv5gpldi	102	7	still	still	RB
cord-302047-vv5gpldi	102	8	rapidly	rapidly	RB
cord-302047-vv5gpldi	102	9	lost	lose	VBN
cord-302047-vv5gpldi	102	10	(	(	-LRB-
cord-302047-vv5gpldi	102	11	Pijlman	Pijlman	NNP
cord-302047-vv5gpldi	102	12	,	,	,
cord-302047-vv5gpldi	102	13	van	van	NNP
cord-302047-vv5gpldi	102	14	Schinjndel	Schinjndel	NNP
cord-302047-vv5gpldi	102	15	,	,	,
cord-302047-vv5gpldi	102	16	and	and	CC
cord-302047-vv5gpldi	102	17	Vlak	Vlak	NNP
cord-302047-vv5gpldi	102	18	2003	2003	CD
cord-302047-vv5gpldi	102	19	)	)	-RRB-
cord-302047-vv5gpldi	102	20	,	,	,
cord-302047-vv5gpldi	102	21	showing	show	VBG
cord-302047-vv5gpldi	102	22	that	that	IN
cord-302047-vv5gpldi	102	23	rapid	rapid	JJ
cord-302047-vv5gpldi	102	24	DI	DI	NNP
cord-302047-vv5gpldi	102	25	generation	generation	NN
cord-302047-vv5gpldi	102	26	is	be	VBZ
cord-302047-vv5gpldi	102	27	not	not	RB
cord-302047-vv5gpldi	102	28	the	the	DT
cord-302047-vv5gpldi	102	29	only	only	JJ
cord-302047-vv5gpldi	102	30	impediment	impediment	NN
cord-302047-vv5gpldi	102	31	to	to	IN
cord-302047-vv5gpldi	102	32	the	the	DT
cord-302047-vv5gpldi	102	33	stability	stability	NN
cord-302047-vv5gpldi	102	34	of	of	IN
cord-302047-vv5gpldi	102	35	inserted	insert	VBN
cord-302047-vv5gpldi	102	36	genes	gene	NNS
cord-302047-vv5gpldi	102	37	.	.	.
cord-302047-vv5gpldi	103	1	Addition	addition	NN
cord-302047-vv5gpldi	103	2	of	of	IN
cord-302047-vv5gpldi	103	3	endogenous	endogenous	JJ
cord-302047-vv5gpldi	103	4	viral	viral	JJ
cord-302047-vv5gpldi	103	5	sequences	sequence	NNS
cord-302047-vv5gpldi	103	6	-	-	:
cord-302047-vv5gpldi	103	7	homologous	homologous	JJ
cord-302047-vv5gpldi	103	8	repeat	repeat	NN
cord-302047-vv5gpldi	103	9	regions	region	NNS
cord-302047-vv5gpldi	103	10	important	important	JJ
cord-302047-vv5gpldi	103	11	for	for	IN
cord-302047-vv5gpldi	103	12	baculovirus	baculovirus	NNP
cord-302047-vv5gpldi	103	13	replication	replication	NN
cord-302047-vv5gpldi	103	14	-	-	:
cord-302047-vv5gpldi	103	15	to	to	IN
cord-302047-vv5gpldi	103	16	inserted	insert	VBN
cord-302047-vv5gpldi	103	17	sequences	sequence	NNS
cord-302047-vv5gpldi	103	18	promoted	promote	VBD
cord-302047-vv5gpldi	103	19	the	the	DT
cord-302047-vv5gpldi	103	20	stability	stability	NN
cord-302047-vv5gpldi	103	21	of	of	IN
cord-302047-vv5gpldi	103	22	insertions	insertion	NNS
cord-302047-vv5gpldi	103	23	(	(	-LRB-
cord-302047-vv5gpldi	103	24	Pijlman	Pijlman	NNP
cord-302047-vv5gpldi	103	25	et	et	FW
cord-302047-vv5gpldi	103	26	al	al	NNP
cord-302047-vv5gpldi	103	27	.	.	.
cord-302047-vv5gpldi	103	28	2004	2004	CD
cord-302047-vv5gpldi	103	29	)	)	-RRB-
cord-302047-vv5gpldi	103	30	,	,	,
cord-302047-vv5gpldi	103	31	highlighting	highlight	VBG
cord-302047-vv5gpldi	103	32	the	the	DT
cord-302047-vv5gpldi	103	33	importance	importance	NN
cord-302047-vv5gpldi	103	34	of	of	IN
cord-302047-vv5gpldi	103	35	the	the	DT
cord-302047-vv5gpldi	103	36	genomic	genomic	JJ
cord-302047-vv5gpldi	103	37	context	context	NN
cord-302047-vv5gpldi	103	38	for	for	IN
cord-302047-vv5gpldi	103	39	insert	insert	JJ
cord-302047-vv5gpldi	103	40	stability	stability	NN
cord-302047-vv5gpldi	103	41	.	.	.
cord-302047-vv5gpldi	104	1	Another	another	DT
cord-302047-vv5gpldi	104	2	study	study	NN
cord-302047-vv5gpldi	104	3	in	in	IN
cord-302047-vv5gpldi	104	4	which	which	WDT
cord-302047-vv5gpldi	104	5	the	the	DT
cord-302047-vv5gpldi	104	6	importance	importance	NN
cord-302047-vv5gpldi	104	7	of	of	IN
cord-302047-vv5gpldi	104	8	the	the	DT
cord-302047-vv5gpldi	104	9	genomic	genomic	JJ
cord-302047-vv5gpldi	104	10	context	context	NN
cord-302047-vv5gpldi	104	11	was	be	VBD
cord-302047-vv5gpldi	104	12	stressed	stress	VBN
cord-302047-vv5gpldi	104	13	involved	involve	VBN
cord-302047-vv5gpldi	104	14	the	the	DT
cord-302047-vv5gpldi	104	15	generation	generation	NN
cord-302047-vv5gpldi	104	16	of	of	IN
cord-302047-vv5gpldi	104	17	infectious	infectious	JJ
cord-302047-vv5gpldi	104	18	clones	clone	NNS
cord-302047-vv5gpldi	104	19	and	and	CC
cord-302047-vv5gpldi	104	20	determination	determination	NN
cord-302047-vv5gpldi	104	21	of	of	IN
cord-302047-vv5gpldi	104	22	the	the	DT
cord-302047-vv5gpldi	104	23	stability	stability	NN
cord-302047-vv5gpldi	104	24	of	of	IN
cord-302047-vv5gpldi	104	25	Suid	suid	JJ
cord-302047-vv5gpldi	104	26	herpesvirus	herpesvirus	NN
cord-302047-vv5gpldi	104	27	1	1	CD
cord-302047-vv5gpldi	104	28	,	,	,
cord-302047-vv5gpldi	104	29	the	the	DT
cord-302047-vv5gpldi	104	30	causal	causal	JJ
cord-302047-vv5gpldi	104	31	agent	agent	NN
cord-302047-vv5gpldi	104	32	of	of	IN
cord-302047-vv5gpldi	104	33	Aujeszky	Aujeszky	NNP
cord-302047-vv5gpldi	104	34	's	's	POS
cord-302047-vv5gpldi	104	35	disease	disease	NN
cord-302047-vv5gpldi	104	36	.	.	.
cord-302047-vv5gpldi	105	1	Sequences	sequence	NNS
cord-302047-vv5gpldi	105	2	inserted	insert	VBN
cord-302047-vv5gpldi	105	3	in	in	IN
cord-302047-vv5gpldi	105	4	infectious	infectious	JJ
cord-302047-vv5gpldi	105	5	clones	clone	NNS
cord-302047-vv5gpldi	105	6	were	be	VBD
cord-302047-vv5gpldi	105	7	genetically	genetically	RB
cord-302047-vv5gpldi	105	8	stable	stable	JJ
cord-302047-vv5gpldi	105	9	in	in	IN
cord-302047-vv5gpldi	105	10	Escherichia	Escherichia	NNP
cord-302047-vv5gpldi	105	11	coli	coli	NNS
cord-302047-vv5gpldi	105	12	.	.	.
cord-302047-vv5gpldi	106	1	However	however	RB
cord-302047-vv5gpldi	106	2	,	,	,
cord-302047-vv5gpldi	106	3	for	for	IN
cord-302047-vv5gpldi	106	4	the	the	DT
cord-302047-vv5gpldi	106	5	reconstituted	reconstitute	VBN
cord-302047-vv5gpldi	106	6	viruses	virus	NNS
cord-302047-vv5gpldi	106	7	,	,	,
cord-302047-vv5gpldi	106	8	the	the	DT
cord-302047-vv5gpldi	106	9	insertion	insertion	NN
cord-302047-vv5gpldi	106	10	at	at	IN
cord-302047-vv5gpldi	106	11	the	the	DT
cord-302047-vv5gpldi	106	12	gG	gG	NNP
cord-302047-vv5gpldi	106	13	locus	locus	NN
cord-302047-vv5gpldi	106	14	was	be	VBD
cord-302047-vv5gpldi	106	15	highly	highly	RB
cord-302047-vv5gpldi	106	16	unstable	unstable	JJ
cord-302047-vv5gpldi	106	17	,	,	,
cord-302047-vv5gpldi	106	18	whereas	whereas	IN
cord-302047-vv5gpldi	106	19	the	the	DT
cord-302047-vv5gpldi	106	20	same	same	JJ
cord-302047-vv5gpldi	106	21	insert	insert	NN
cord-302047-vv5gpldi	106	22	was	be	VBD
cord-302047-vv5gpldi	106	23	stable	stable	JJ
cord-302047-vv5gpldi	106	24	when	when	WRB
cord-302047-vv5gpldi	106	25	inserted	insert	VBN
cord-302047-vv5gpldi	106	26	between	between	IN
cord-302047-vv5gpldi	106	27	the	the	DT
cord-302047-vv5gpldi	106	28	Us9	us9	CD
cord-302047-vv5gpldi	106	29	and	and	CC
cord-302047-vv5gpldi	106	30	Us2	us2	JJ
cord-302047-vv5gpldi	106	31	genes	gene	NNS
cord-302047-vv5gpldi	106	32	(	(	-LRB-
cord-302047-vv5gpldi	106	33	Smith	Smith	NNP
cord-302047-vv5gpldi	106	34	and	and	CC
cord-302047-vv5gpldi	106	35	Enquist	Enquist	NNP
cord-302047-vv5gpldi	106	36	1999	1999	CD
cord-302047-vv5gpldi	106	37	,	,	,
cord-302047-vv5gpldi	106	38	2000	2000	CD
cord-302047-vv5gpldi	106	39	)	)	-RRB-
cord-302047-vv5gpldi	106	40	.	.	.
cord-302047-vv5gpldi	107	1	Stability	stability	NN
cord-302047-vv5gpldi	107	2	was	be	VBD
cord-302047-vv5gpldi	107	3	only	only	RB
cord-302047-vv5gpldi	107	4	determined	determine	VBN
cord-302047-vv5gpldi	107	5	in	in	IN
cord-302047-vv5gpldi	107	6	a	a	DT
cord-302047-vv5gpldi	107	7	short	short	JJ
cord-302047-vv5gpldi	107	8	-	-	HYPH
cord-302047-vv5gpldi	107	9	term	term	NN
cord-302047-vv5gpldi	107	10	experiment	experiment	NN
cord-302047-vv5gpldi	107	11	,	,	,
cord-302047-vv5gpldi	107	12	but	but	CC
cord-302047-vv5gpldi	107	13	these	these	DT
cord-302047-vv5gpldi	107	14	results	result	NNS
cord-302047-vv5gpldi	107	15	nevertheless	nevertheless	RB
cord-302047-vv5gpldi	107	16	emphasize	emphasize	VBP
cord-302047-vv5gpldi	107	17	the	the	DT
cord-302047-vv5gpldi	107	18	importance	importance	NN
cord-302047-vv5gpldi	107	19	of	of	IN
cord-302047-vv5gpldi	107	20	the	the	DT
cord-302047-vv5gpldi	107	21	genomic	genomic	JJ
cord-302047-vv5gpldi	107	22	context	context	NN
cord-302047-vv5gpldi	107	23	for	for	IN
cord-302047-vv5gpldi	107	24	stability	stability	NN
cord-302047-vv5gpldi	107	25	,	,	,
cord-302047-vv5gpldi	107	26	even	even	RB
cord-302047-vv5gpldi	107	27	in	in	IN
cord-302047-vv5gpldi	107	28	viruses	virus	NNS
cord-302047-vv5gpldi	107	29	with	with	IN
cord-302047-vv5gpldi	107	30	relatively	relatively	RB
cord-302047-vv5gpldi	107	31	large	large	JJ
cord-302047-vv5gpldi	107	32	and	and	CC
cord-302047-vv5gpldi	107	33	stable	stable	JJ
cord-302047-vv5gpldi	107	34	genomes	genome	NNS
cord-302047-vv5gpldi	107	35	.	.	.
cord-302047-vv5gpldi	108	1	Bacteriophages	bacteriophage	NNS
cord-302047-vv5gpldi	108	2	were	be	VBD
cord-302047-vv5gpldi	108	3	instrumental	instrumental	JJ
cord-302047-vv5gpldi	108	4	in	in	IN
cord-302047-vv5gpldi	108	5	the	the	DT
cord-302047-vv5gpldi	108	6	development	development	NN
cord-302047-vv5gpldi	108	7	of	of	IN
cord-302047-vv5gpldi	108	8	molecular	molecular	JJ
cord-302047-vv5gpldi	108	9	cloning	cloning	NN
cord-302047-vv5gpldi	108	10	methods	method	NNS
cord-302047-vv5gpldi	108	11	.	.	.
cord-302047-vv5gpldi	109	1	Among	among	IN
cord-302047-vv5gpldi	109	2	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	109	3	phages	phage	NNS
cord-302047-vv5gpldi	109	4	,	,	,
cord-302047-vv5gpldi	109	5	lambdaviruses	lambdaviruse	NNS
cord-302047-vv5gpldi	109	6	of	of	IN
cord-302047-vv5gpldi	109	7	E.coli	E.coli	NNS
cord-302047-vv5gpldi	109	8	were	be	VBD
cord-302047-vv5gpldi	109	9	widely	widely	RB
cord-302047-vv5gpldi	109	10	used	use	VBN
cord-302047-vv5gpldi	109	11	as	as	IN
cord-302047-vv5gpldi	109	12	cloning	clone	VBG
cord-302047-vv5gpldi	109	13	vectors	vector	NNS
cord-302047-vv5gpldi	109	14	,	,	,
cord-302047-vv5gpldi	109	15	and	and	CC
cord-302047-vv5gpldi	109	16	methods	method	NNS
cord-302047-vv5gpldi	109	17	were	be	VBD
cord-302047-vv5gpldi	109	18	developed	develop	VBN
cord-302047-vv5gpldi	109	19	to	to	TO
cord-302047-vv5gpldi	109	20	increase	increase	VB
cord-302047-vv5gpldi	109	21	the	the	DT
cord-302047-vv5gpldi	109	22	stability	stability	NN
cord-302047-vv5gpldi	109	23	and	and	CC
cord-302047-vv5gpldi	109	24	maximum	maximum	JJ
cord-302047-vv5gpldi	109	25	size	size	NN
cord-302047-vv5gpldi	109	26	of	of	IN
cord-302047-vv5gpldi	109	27	inserts	insert	NNS
cord-302047-vv5gpldi	109	28	(	(	-LRB-
cord-302047-vv5gpldi	109	29	Chauthaiwale	Chauthaiwale	NNP
cord-302047-vv5gpldi	109	30	,	,	,
cord-302047-vv5gpldi	109	31	Therwath	Therwath	NNP
cord-302047-vv5gpldi	109	32	,	,	,
cord-302047-vv5gpldi	109	33	and	and	CC
cord-302047-vv5gpldi	109	34	Deshpande	Deshpande	NNP
cord-302047-vv5gpldi	109	35	1992	1992	CD
cord-302047-vv5gpldi	109	36	)	)	-RRB-
cord-302047-vv5gpldi	109	37	.	.	.
cord-302047-vv5gpldi	110	1	One	one	CD
cord-302047-vv5gpldi	110	2	interesting	interesting	JJ
cord-302047-vv5gpldi	110	3	approach	approach	NN
cord-302047-vv5gpldi	110	4	made	make	VBD
cord-302047-vv5gpldi	110	5	use	use	NN
cord-302047-vv5gpldi	110	6	of	of	IN
cord-302047-vv5gpldi	110	7	the	the	DT
cord-302047-vv5gpldi	110	8	fact	fact	NN
cord-302047-vv5gpldi	110	9	that	that	IN
cord-302047-vv5gpldi	110	10	there	there	EX
cord-302047-vv5gpldi	110	11	is	be	VBZ
cord-302047-vv5gpldi	110	12	a	a	DT
cord-302047-vv5gpldi	110	13	minimum	minimum	JJ
cord-302047-vv5gpldi	110	14	genome	genome	NN
cord-302047-vv5gpldi	110	15	size	size	NN
cord-302047-vv5gpldi	110	16	for	for	IN
cord-302047-vv5gpldi	110	17	efficient	efficient	JJ
cord-302047-vv5gpldi	110	18	packaging	packaging	NN
cord-302047-vv5gpldi	110	19	into	into	IN
cord-302047-vv5gpldi	110	20	virus	virus	NN
cord-302047-vv5gpldi	110	21	particles	particle	NNS
cord-302047-vv5gpldi	110	22	.	.	.
cord-302047-vv5gpldi	111	1	When	when	WRB
cord-302047-vv5gpldi	111	2	endogenous	endogenous	JJ
cord-302047-vv5gpldi	111	3	genes	gene	NNS
cord-302047-vv5gpldi	111	4	that	that	WDT
cord-302047-vv5gpldi	111	5	are	be	VBP
cord-302047-vv5gpldi	111	6	non	non	JJ
cord-302047-vv5gpldi	111	7	-	-	JJ
cord-302047-vv5gpldi	111	8	essential	essential	JJ
cord-302047-vv5gpldi	111	9	for	for	IN
cord-302047-vv5gpldi	111	10	the	the	DT
cord-302047-vv5gpldi	111	11	lytic	lytic	JJ
cord-302047-vv5gpldi	111	12	cycle	cycle	NN
cord-302047-vv5gpldi	111	13	are	be	VBP
cord-302047-vv5gpldi	111	14	removed	remove	VBN
cord-302047-vv5gpldi	111	15	,	,	,
cord-302047-vv5gpldi	111	16	not	not	RB
cord-302047-vv5gpldi	111	17	only	only	RB
cord-302047-vv5gpldi	111	18	can	can	MD
cord-302047-vv5gpldi	111	19	larger	large	JJR
cord-302047-vv5gpldi	111	20	sequences	sequence	NNS
cord-302047-vv5gpldi	111	21	be	be	VB
cord-302047-vv5gpldi	111	22	inserted	insert	VBN
cord-302047-vv5gpldi	111	23	,	,	,
cord-302047-vv5gpldi	111	24	but	but	CC
cord-302047-vv5gpldi	111	25	there	there	EX
cord-302047-vv5gpldi	111	26	is	be	VBZ
cord-302047-vv5gpldi	111	27	also	also	RB
cord-302047-vv5gpldi	111	28	selection	selection	NN
cord-302047-vv5gpldi	111	29	for	for	IN
cord-302047-vv5gpldi	111	30	maintaining	maintain	VBG
cord-302047-vv5gpldi	111	31	the	the	DT
cord-302047-vv5gpldi	111	32	inserted	insert	VBN
cord-302047-vv5gpldi	111	33	sequences	sequence	NNS
cord-302047-vv5gpldi	111	34	because	because	IN
cord-302047-vv5gpldi	111	35	they	-PRON-	PRP
cord-302047-vv5gpldi	111	36	increase	increase	VBP
cord-302047-vv5gpldi	111	37	genome	genome	NN
cord-302047-vv5gpldi	111	38	size	size	NN
cord-302047-vv5gpldi	111	39	and	and	CC
cord-302047-vv5gpldi	111	40	enable	enable	VB
cord-302047-vv5gpldi	111	41	packaging	packaging	NN
cord-302047-vv5gpldi	111	42	(	(	-LRB-
cord-302047-vv5gpldi	111	43	Thomas	Thomas	NNP
cord-302047-vv5gpldi	111	44	,	,	,
cord-302047-vv5gpldi	111	45	Cameron	Cameron	NNP
cord-302047-vv5gpldi	111	46	,	,	,
cord-302047-vv5gpldi	111	47	and	and	CC
cord-302047-vv5gpldi	111	48	Davis	Davis	NNP
cord-302047-vv5gpldi	111	49	1974	1974	CD
cord-302047-vv5gpldi	111	50	)	)	-RRB-
cord-302047-vv5gpldi	111	51	.	.	.
cord-302047-vv5gpldi	112	1	Moreover	moreover	RB
cord-302047-vv5gpldi	112	2	,	,	,
cord-302047-vv5gpldi	112	3	it	-PRON-	PRP
cord-302047-vv5gpldi	112	4	has	have	VBZ
cord-302047-vv5gpldi	112	5	been	be	VBN
cord-302047-vv5gpldi	112	6	shown	show	VBN
cord-302047-vv5gpldi	112	7	that	that	IN
cord-302047-vv5gpldi	112	8	phage	phage	NN
cord-302047-vv5gpldi	112	9	T7	t7	NN
cord-302047-vv5gpldi	112	10	engineered	engineer	VBN
cord-302047-vv5gpldi	112	11	with	with	IN
cord-302047-vv5gpldi	112	12	a	a	DT
cord-302047-vv5gpldi	112	13	biofilm	biofilm	NN
cord-302047-vv5gpldi	112	14	-	-	HYPH
cord-302047-vv5gpldi	112	15	degrading	degrade	VBG
cord-302047-vv5gpldi	112	16	enzyme	enzyme	NN
cord-302047-vv5gpldi	112	17	(	(	-LRB-
cord-302047-vv5gpldi	112	18	dispersin	dispersin	NNP
cord-302047-vv5gpldi	112	19	B	B	NNP
cord-302047-vv5gpldi	112	20	)	)	-RRB-
cord-302047-vv5gpldi	112	21	was	be	VBD
cord-302047-vv5gpldi	112	22	superior	superior	JJ
cord-302047-vv5gpldi	112	23	to	to	IN
cord-302047-vv5gpldi	112	24	unmodified	unmodified	JJ
cord-302047-vv5gpldi	112	25	phage	phage	NN
cord-302047-vv5gpldi	112	26	at	at	IN
cord-302047-vv5gpldi	112	27	clearing	clear	VBG
cord-302047-vv5gpldi	112	28	short	short	JJ
cord-302047-vv5gpldi	112	29	-	-	HYPH
cord-302047-vv5gpldi	112	30	term	term	NN
cord-302047-vv5gpldi	112	31	biofilms	biofilm	NNS
cord-302047-vv5gpldi	112	32	(	(	-LRB-
cord-302047-vv5gpldi	112	33	Lu	Lu	NNP
cord-302047-vv5gpldi	112	34	and	and	CC
cord-302047-vv5gpldi	112	35	Collins	Collins	NNP
cord-302047-vv5gpldi	112	36	2007	2007	CD
cord-302047-vv5gpldi	112	37	)	)	-RRB-
cord-302047-vv5gpldi	112	38	.	.	.
cord-302047-vv5gpldi	113	1	Although	although	IN
cord-302047-vv5gpldi	113	2	providing	provide	VBG
cord-302047-vv5gpldi	113	3	a	a	DT
cord-302047-vv5gpldi	113	4	'	'	``
cord-302047-vv5gpldi	113	5	public	public	JJ
cord-302047-vv5gpldi	113	6	'	'	''
cord-302047-vv5gpldi	113	7	benefit	benefit	NN
cord-302047-vv5gpldi	113	8	in	in	IN
cord-302047-vv5gpldi	113	9	the	the	DT
cord-302047-vv5gpldi	113	10	form	form	NN
cord-302047-vv5gpldi	113	11	of	of	IN
cord-302047-vv5gpldi	113	12	an	an	DT
cord-302047-vv5gpldi	113	13	exoenzyme	exoenzyme	NNS
cord-302047-vv5gpldi	113	14	that	that	WDT
cord-302047-vv5gpldi	113	15	can	can	MD
cord-302047-vv5gpldi	113	16	degrade	degrade	VB
cord-302047-vv5gpldi	113	17	host	host	NN
cord-302047-vv5gpldi	113	18	defenses	defense	NNS
cord-302047-vv5gpldi	113	19	,	,	,
cord-302047-vv5gpldi	113	20	surprisingly	surprisingly	RB
cord-302047-vv5gpldi	113	21	this	this	DT
cord-302047-vv5gpldi	113	22	insertion	insertion	NN
cord-302047-vv5gpldi	113	23	does	do	VBZ
cord-302047-vv5gpldi	113	24	not	not	RB
cord-302047-vv5gpldi	113	25	have	have	VB
cord-302047-vv5gpldi	113	26	a	a	DT
cord-302047-vv5gpldi	113	27	cost	cost	NN
cord-302047-vv5gpldi	113	28	and	and	CC
cord-302047-vv5gpldi	113	29	is	be	VBZ
cord-302047-vv5gpldi	113	30	therefore	therefore	RB
cord-302047-vv5gpldi	113	31	stable	stable	JJ
cord-302047-vv5gpldi	114	1	(	(	-LRB-
cord-302047-vv5gpldi	114	2	Schmerer	Schmerer	NNP
cord-302047-vv5gpldi	114	3	et	et	NNP
cord-302047-vv5gpldi	114	4	al	al	NNP
cord-302047-vv5gpldi	114	5	.	.	NNP
cord-302047-vv5gpldi	114	6	2014	2014	CD
cord-302047-vv5gpldi	114	7	)	)	-RRB-
cord-302047-vv5gpldi	114	8	.	.	.
cord-302047-vv5gpldi	115	1	Interestingly	interestingly	RB
cord-302047-vv5gpldi	115	2	,	,	,
cord-302047-vv5gpldi	115	3	the	the	DT
cord-302047-vv5gpldi	115	4	insertion	insertion	NN
cord-302047-vv5gpldi	115	5	of	of	IN
cord-302047-vv5gpldi	115	6	an	an	DT
cord-302047-vv5gpldi	115	7	endosialidase	endosialidase	NN
cord-302047-vv5gpldi	115	8	at	at	IN
cord-302047-vv5gpldi	115	9	the	the	DT
cord-302047-vv5gpldi	115	10	same	same	JJ
cord-302047-vv5gpldi	115	11	locus	locus	NN
cord-302047-vv5gpldi	115	12	was	be	VBD
cord-302047-vv5gpldi	115	13	both	both	DT
cord-302047-vv5gpldi	115	14	beneficial	beneficial	JJ
cord-302047-vv5gpldi	115	15	and	and	CC
cord-302047-vv5gpldi	115	16	costly	costly	JJ
cord-302047-vv5gpldi	115	17	,	,	,
cord-302047-vv5gpldi	115	18	although	although	IN
cord-302047-vv5gpldi	115	19	in	in	IN
cord-302047-vv5gpldi	115	20	this	this	DT
cord-302047-vv5gpldi	115	21	case	case	NN
cord-302047-vv5gpldi	115	22	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	115	23	stability	stability	NN
cord-302047-vv5gpldi	115	24	was	be	VBD
cord-302047-vv5gpldi	115	25	not	not	RB
cord-302047-vv5gpldi	115	26	determined	determine	VBN
cord-302047-vv5gpldi	115	27	(	(	-LRB-
cord-302047-vv5gpldi	115	28	Gladstone	Gladstone	NNP
cord-302047-vv5gpldi	115	29	,	,	,
cord-302047-vv5gpldi	115	30	Molineux	Molineux	NNP
cord-302047-vv5gpldi	115	31	,	,	,
cord-302047-vv5gpldi	115	32	and	and	CC
cord-302047-vv5gpldi	115	33	Bull	Bull	NNP
cord-302047-vv5gpldi	115	34	2012	2012	CD
cord-302047-vv5gpldi	115	35	)	)	-RRB-
cord-302047-vv5gpldi	115	36	.	.	.
cord-302047-vv5gpldi	116	1	In	in	IN
cord-302047-vv5gpldi	116	2	summary	summary	NN
cord-302047-vv5gpldi	116	3	,	,	,
cord-302047-vv5gpldi	116	4	engineered	engineer	VBN
cord-302047-vv5gpldi	116	5	dsDNA	dsdna	RB
cord-302047-vv5gpldi	116	6	viruses	virus	NNS
cord-302047-vv5gpldi	116	7	containing	contain	VBG
cord-302047-vv5gpldi	116	8	foreign	foreign	JJ
cord-302047-vv5gpldi	116	9	gene	gene	NN
cord-302047-vv5gpldi	116	10	insertions	insertion	NNS
cord-302047-vv5gpldi	116	11	are	be	VBP
cord-302047-vv5gpldi	116	12	relatively	relatively	RB
cord-302047-vv5gpldi	116	13	unstable	unstable	JJ
cord-302047-vv5gpldi	116	14	and	and	CC
cord-302047-vv5gpldi	116	15	stability	stability	NN
cord-302047-vv5gpldi	116	16	is	be	VBZ
cord-302047-vv5gpldi	116	17	only	only	RB
cord-302047-vv5gpldi	116	18	reached	reach	VBN
cord-302047-vv5gpldi	116	19	when	when	WRB
cord-302047-vv5gpldi	116	20	the	the	DT
cord-302047-vv5gpldi	116	21	genomic	genomic	JJ
cord-302047-vv5gpldi	116	22	context	context	NN
cord-302047-vv5gpldi	116	23	and	and	CC
cord-302047-vv5gpldi	116	24	demographic	demographic	JJ
cord-302047-vv5gpldi	116	25	conditions	condition	NNS
cord-302047-vv5gpldi	116	26	(	(	-LRB-
cord-302047-vv5gpldi	116	27	e.g.	e.g.	IN
cord-302047-vv5gpldi	116	28	census	census	NN
cord-302047-vv5gpldi	116	29	population	population	NN
cord-302047-vv5gpldi	116	30	sizes	size	NNS
cord-302047-vv5gpldi	116	31	,	,	,
cord-302047-vv5gpldi	116	32	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	116	33	sizes	size	NNS
cord-302047-vv5gpldi	116	34	,	,	,
cord-302047-vv5gpldi	116	35	and	and	CC
cord-302047-vv5gpldi	116	36	population	population	NN
cord-302047-vv5gpldi	116	37	structure	structure	NN
cord-302047-vv5gpldi	116	38	)	)	-RRB-
cord-302047-vv5gpldi	116	39	are	be	VBP
cord-302047-vv5gpldi	116	40	optimal	optimal	JJ
cord-302047-vv5gpldi	116	41	.	.	.
cord-302047-vv5gpldi	117	1	Contrarily	contrarily	RB
cord-302047-vv5gpldi	117	2	,	,	,
cord-302047-vv5gpldi	117	3	in	in	IN
cord-302047-vv5gpldi	117	4	natural	natural	JJ
cord-302047-vv5gpldi	117	5	conditions	condition	NNS
cord-302047-vv5gpldi	117	6	dsDNA	dsdna	RB
cord-302047-vv5gpldi	117	7	viruses	virus	NNS
cord-302047-vv5gpldi	117	8	appear	appear	VBP
cord-302047-vv5gpldi	117	9	to	to	TO
cord-302047-vv5gpldi	117	10	be	be	VB
cord-302047-vv5gpldi	117	11	highly	highly	RB
cord-302047-vv5gpldi	117	12	plastic	plastic	JJ
cord-302047-vv5gpldi	117	13	where	where	WRB
cord-302047-vv5gpldi	117	14	increases	increase	NNS
cord-302047-vv5gpldi	117	15	and	and	CC
cord-302047-vv5gpldi	117	16	decreases	decrease	NNS
cord-302047-vv5gpldi	117	17	in	in	IN
cord-302047-vv5gpldi	117	18	genome	genome	NN
cord-302047-vv5gpldi	117	19	size	size	NN
cord-302047-vv5gpldi	117	20	occur	occur	VBP
cord-302047-vv5gpldi	117	21	on	on	IN
cord-302047-vv5gpldi	117	22	a	a	DT
cord-302047-vv5gpldi	117	23	relatively	relatively	RB
cord-302047-vv5gpldi	117	24	short	short	JJ
cord-302047-vv5gpldi	117	25	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	117	26	time	time	NN
cord-302047-vv5gpldi	117	27	scale	scale	NN
cord-302047-vv5gpldi	117	28	.	.	.
cord-302047-vv5gpldi	118	1	In	in	IN
cord-302047-vv5gpldi	118	2	particular	particular	JJ
cord-302047-vv5gpldi	118	3	,	,	,
cord-302047-vv5gpldi	118	4	host	host	NN
cord-302047-vv5gpldi	118	5	-	-	HYPH
cord-302047-vv5gpldi	118	6	switches	switch	NNS
cord-302047-vv5gpldi	118	7	may	may	MD
cord-302047-vv5gpldi	118	8	play	play	VB
cord-302047-vv5gpldi	118	9	important	important	JJ
cord-302047-vv5gpldi	118	10	roles	role	NNS
cord-302047-vv5gpldi	118	11	in	in	IN
cord-302047-vv5gpldi	118	12	increased	increase	VBN
cord-302047-vv5gpldi	118	13	plasticity	plasticity	NN
cord-302047-vv5gpldi	118	14	and	and	CC
cord-302047-vv5gpldi	118	15	stability	stability	NN
cord-302047-vv5gpldi	118	16	of	of	IN
cord-302047-vv5gpldi	118	17	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	118	18	viral	viral	JJ
cord-302047-vv5gpldi	118	19	genomes	genome	NNS
cord-302047-vv5gpldi	118	20	.	.	.
cord-302047-vv5gpldi	119	1	Even	even	RB
cord-302047-vv5gpldi	119	2	though	though	IN
cord-302047-vv5gpldi	119	3	unstable	unstable	JJ
cord-302047-vv5gpldi	119	4	viral	viral	JJ
cord-302047-vv5gpldi	119	5	genomes	genome	NNS
cord-302047-vv5gpldi	119	6	may	may	MD
cord-302047-vv5gpldi	119	7	help	help	VB
cord-302047-vv5gpldi	119	8	increase	increase	VB
cord-302047-vv5gpldi	119	9	viral	viral	JJ
cord-302047-vv5gpldi	119	10	fitness	fitness	NN
cord-302047-vv5gpldi	119	11	by	by	IN
cord-302047-vv5gpldi	119	12	avoiding	avoid	VBG
cord-302047-vv5gpldi	119	13	the	the	DT
cord-302047-vv5gpldi	119	14	hosts	host	NNS
cord-302047-vv5gpldi	119	15	'	'	POS
cord-302047-vv5gpldi	119	16	immune	immune	JJ
cord-302047-vv5gpldi	119	17	system	system	NN
cord-302047-vv5gpldi	119	18	in	in	IN
cord-302047-vv5gpldi	119	19	natural	natural	JJ
cord-302047-vv5gpldi	119	20	conditions	condition	NNS
cord-302047-vv5gpldi	119	21	,	,	,
cord-302047-vv5gpldi	119	22	it	-PRON-	PRP
cord-302047-vv5gpldi	119	23	may	may	MD
cord-302047-vv5gpldi	119	24	also	also	RB
cord-302047-vv5gpldi	119	25	prevent	prevent	VB
cord-302047-vv5gpldi	119	26	the	the	DT
cord-302047-vv5gpldi	119	27	development	development	NN
cord-302047-vv5gpldi	119	28	of	of	IN
cord-302047-vv5gpldi	119	29	stable	stable	JJ
cord-302047-vv5gpldi	119	30	viral	viral	JJ
cord-302047-vv5gpldi	119	31	expression	expression	NN
cord-302047-vv5gpldi	119	32	vectors	vector	NNS
cord-302047-vv5gpldi	119	33	in	in	IN
cord-302047-vv5gpldi	119	34	bioreactor	bioreactor	NN
cord-302047-vv5gpldi	119	35	configurations	configuration	NNS
cord-302047-vv5gpldi	119	36	.	.	.
cord-302047-vv5gpldi	120	1	The	the	DT
cord-302047-vv5gpldi	120	2	ssDNA	ssdna	JJ
cord-302047-vv5gpldi	120	3	viruses	virus	NNS
cord-302047-vv5gpldi	120	4	have	have	VBP
cord-302047-vv5gpldi	120	5	much	much	RB
cord-302047-vv5gpldi	120	6	smaller	small	JJR
cord-302047-vv5gpldi	120	7	genome	genome	NN
cord-302047-vv5gpldi	120	8	sizes	size	NNS
cord-302047-vv5gpldi	120	9	as	as	IN
cord-302047-vv5gpldi	120	10	compared	compare	VBN
cord-302047-vv5gpldi	120	11	to	to	IN
cord-302047-vv5gpldi	120	12	the	the	DT
cord-302047-vv5gpldi	120	13	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	120	14	viruses	virus	NNS
cord-302047-vv5gpldi	120	15	(	(	-LRB-
cord-302047-vv5gpldi	120	16	group	group	NN
cord-302047-vv5gpldi	120	17	I	I	NNP
cord-302047-vv5gpldi	120	18	)	)	-RRB-
cord-302047-vv5gpldi	120	19	,	,	,
cord-302047-vv5gpldi	120	20	ranging	range	VBG
cord-302047-vv5gpldi	120	21	from	from	IN
cord-302047-vv5gpldi	120	22	1.8	1.8	CD
cord-302047-vv5gpldi	120	23	to	to	IN
cord-302047-vv5gpldi	120	24	2.3	2.3	CD
cord-302047-vv5gpldi	120	25	kbp	kbp	NNS
cord-302047-vv5gpldi	120	26	genomes	genome	NNS
cord-302047-vv5gpldi	120	27	of	of	IN
cord-302047-vv5gpldi	120	28	the	the	DT
cord-302047-vv5gpldi	120	29	Circoviridae	Circoviridae	NNP
cord-302047-vv5gpldi	120	30	to	to	IN
cord-302047-vv5gpldi	120	31	the	the	DT
cord-302047-vv5gpldi	120	32	24.9	24.9	CD
cord-302047-vv5gpldi	120	33	kbp	kbp	NNP
cord-302047-vv5gpldi	120	34	genome	genome	NN
cord-302047-vv5gpldi	120	35	of	of	IN
cord-302047-vv5gpldi	120	36	the	the	DT
cord-302047-vv5gpldi	120	37	Spiraviridae	Spiraviridae	NNP
cord-302047-vv5gpldi	120	38	.	.	.
cord-302047-vv5gpldi	121	1	Judging	judge	VBG
cord-302047-vv5gpldi	121	2	only	only	RB
cord-302047-vv5gpldi	121	3	by	by	IN
cord-302047-vv5gpldi	121	4	the	the	DT
cord-302047-vv5gpldi	121	5	small	small	JJ
cord-302047-vv5gpldi	121	6	range	range	NN
cord-302047-vv5gpldi	121	7	in	in	IN
cord-302047-vv5gpldi	121	8	genome	genome	NN
cord-302047-vv5gpldi	121	9	size	size	NN
cord-302047-vv5gpldi	121	10	,	,	,
cord-302047-vv5gpldi	121	11	one	one	PRP
cord-302047-vv5gpldi	121	12	would	would	MD
cord-302047-vv5gpldi	121	13	expect	expect	VB
cord-302047-vv5gpldi	121	14	that	that	IN
cord-302047-vv5gpldi	121	15	ssDNA	ssdna	NN
cord-302047-vv5gpldi	121	16	viruses	virus	NNS
cord-302047-vv5gpldi	121	17	are	be	VBP
cord-302047-vv5gpldi	121	18	less	less	JJR
cord-302047-vv5gpldi	121	19	plastic	plastic	NN
cord-302047-vv5gpldi	121	20	compared	compare	VBD
cord-302047-vv5gpldi	121	21	their	-PRON-	PRP$
cord-302047-vv5gpldi	121	22	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	121	23	counterparts	counterpart	NNS
cord-302047-vv5gpldi	121	24	,	,	,
cord-302047-vv5gpldi	121	25	and	and	CC
cord-302047-vv5gpldi	121	26	thus	thus	RB
cord-302047-vv5gpldi	121	27	less	less	RBR
cord-302047-vv5gpldi	121	28	likely	likely	JJ
cord-302047-vv5gpldi	121	29	to	to	TO
cord-302047-vv5gpldi	121	30	accept	accept	VB
cord-302047-vv5gpldi	121	31	foreign	foreign	JJ
cord-302047-vv5gpldi	121	32	genes	gene	NNS
cord-302047-vv5gpldi	121	33	in	in	IN
cord-302047-vv5gpldi	121	34	their	-PRON-	PRP$
cord-302047-vv5gpldi	121	35	genomes	genome	NNS
cord-302047-vv5gpldi	121	36	.	.	.
cord-302047-vv5gpldi	122	1	Although	although	IN
cord-302047-vv5gpldi	122	2	few	few	JJ
cord-302047-vv5gpldi	122	3	studies	study	NNS
cord-302047-vv5gpldi	122	4	have	have	VBP
cord-302047-vv5gpldi	122	5	addressed	address	VBN
cord-302047-vv5gpldi	122	6	genomic	genomic	JJ
cord-302047-vv5gpldi	122	7	stability	stability	NN
cord-302047-vv5gpldi	122	8	of	of	IN
cord-302047-vv5gpldi	122	9	ssDNA	ssdna	NN
cord-302047-vv5gpldi	122	10	viruses	virus	NNS
cord-302047-vv5gpldi	122	11	after	after	IN
cord-302047-vv5gpldi	122	12	an	an	DT
cord-302047-vv5gpldi	122	13	insertion	insertion	NN
cord-302047-vv5gpldi	122	14	,	,	,
cord-302047-vv5gpldi	122	15	an	an	DT
cord-302047-vv5gpldi	122	16	example	example	NN
cord-302047-vv5gpldi	122	17	in	in	IN
cord-302047-vv5gpldi	122	18	wild	wild	JJ
cord-302047-vv5gpldi	122	19	viruses	virus	NNS
cord-302047-vv5gpldi	122	20	of	of	IN
cord-302047-vv5gpldi	122	21	frequent	frequent	JJ
cord-302047-vv5gpldi	122	22	sequence	sequence	NN
cord-302047-vv5gpldi	122	23	insertions	insertion	NNS
cord-302047-vv5gpldi	122	24	,	,	,
cord-302047-vv5gpldi	122	25	duplications	duplication	NNS
cord-302047-vv5gpldi	122	26	,	,	,
cord-302047-vv5gpldi	122	27	and	and	CC
cord-302047-vv5gpldi	122	28	deletions	deletion	NNS
cord-302047-vv5gpldi	122	29	are	be	VBP
cord-302047-vv5gpldi	122	30	the	the	DT
cord-302047-vv5gpldi	122	31	Geminiviridae	Geminiviridae	NNP
cord-302047-vv5gpldi	122	32	,	,	,
cord-302047-vv5gpldi	122	33	with	with	IN
cord-302047-vv5gpldi	122	34	genomes	genome	NNS
cord-302047-vv5gpldi	122	35	of	of	IN
cord-302047-vv5gpldi	122	36	about	about	RB
cord-302047-vv5gpldi	122	37	2.5	2.5	CD
cord-302047-vv5gpldi	122	38	-	-	SYM
cord-302047-vv5gpldi	122	39	3	3	CD
cord-302047-vv5gpldi	122	40	kbp	kbp	NNP
cord-302047-vv5gpldi	122	41	(	(	-LRB-
cord-302047-vv5gpldi	122	42	monopartite	monopartite	NNP
cord-302047-vv5gpldi	122	43	)	)	-RRB-
cord-302047-vv5gpldi	122	44	or	or	CC
cord-302047-vv5gpldi	122	45	4.8	4.8	CD
cord-302047-vv5gpldi	122	46	-	-	SYM
cord-302047-vv5gpldi	122	47	5.6	5.6	CD
cord-302047-vv5gpldi	122	48	kbp	kbp	NNS
cord-302047-vv5gpldi	122	49	(	(	-LRB-
cord-302047-vv5gpldi	122	50	bipartite	bipartite	JJ
cord-302047-vv5gpldi	122	51	)	)	-RRB-
cord-302047-vv5gpldi	122	52	.	.	.
cord-302047-vv5gpldi	123	1	During	during	IN
cord-302047-vv5gpldi	123	2	the	the	DT
cord-302047-vv5gpldi	123	3	course	course	NN
cord-302047-vv5gpldi	123	4	of	of	IN
cord-302047-vv5gpldi	123	5	geminivirus	geminivirus	NNP
cord-302047-vv5gpldi	123	6	infection	infection	NN
cord-302047-vv5gpldi	123	7	in	in	IN
cord-302047-vv5gpldi	123	8	plants	plant	NNS
cord-302047-vv5gpldi	123	9	,	,	,
cord-302047-vv5gpldi	123	10	shorter	short	JJR
cord-302047-vv5gpldi	123	11	subgenomic	subgenomic	JJ
cord-302047-vv5gpldi	123	12	DNAs	dna	NNS
cord-302047-vv5gpldi	123	13	often	often	RB
cord-302047-vv5gpldi	123	14	arise	arise	VBP
cord-302047-vv5gpldi	123	15	.	.	.
cord-302047-vv5gpldi	124	1	These	these	DT
cord-302047-vv5gpldi	124	2	subgenomic	subgenomic	NNP
cord-302047-vv5gpldi	124	3	DNAs	dna	NNS
cord-302047-vv5gpldi	124	4	can	can	MD
cord-302047-vv5gpldi	124	5	range	range	VB
cord-302047-vv5gpldi	124	6	in	in	IN
cord-302047-vv5gpldi	124	7	size	size	NN
cord-302047-vv5gpldi	124	8	and	and	CC
cord-302047-vv5gpldi	124	9	some	some	DT
cord-302047-vv5gpldi	124	10	result	result	NN
cord-302047-vv5gpldi	124	11	in	in	IN
cord-302047-vv5gpldi	124	12	defective	defective	JJ
cord-302047-vv5gpldi	124	13	DNAs	dna	NNS
cord-302047-vv5gpldi	124	14	(	(	-LRB-
cord-302047-vv5gpldi	124	15	Stenger	Stenger	NNP
cord-302047-vv5gpldi	124	16	et	et	NNP
cord-302047-vv5gpldi	124	17	al	al	NNP
cord-302047-vv5gpldi	124	18	.	.	NNP
cord-302047-vv5gpldi	124	19	1992	1992	CD
cord-302047-vv5gpldi	124	20	;	;	:
cord-302047-vv5gpldi	124	21	Stanley	Stanley	NNP
cord-302047-vv5gpldi	124	22	et	et	NNP
cord-302047-vv5gpldi	124	23	al	al	NNP
cord-302047-vv5gpldi	124	24	.	.	.
cord-302047-vv5gpldi	124	25	1997	1997	CD
cord-302047-vv5gpldi	124	26	;	;	:
cord-302047-vv5gpldi	124	27	Patil	Patil	NNP
cord-302047-vv5gpldi	124	28	et	et	NNP
cord-302047-vv5gpldi	124	29	al	al	NNP
cord-302047-vv5gpldi	124	30	.	.	NNP
cord-302047-vv5gpldi	124	31	2007	2007	CD
cord-302047-vv5gpldi	124	32	)	)	-RRB-
cord-302047-vv5gpldi	124	33	,	,	,
cord-302047-vv5gpldi	124	34	that	that	WDT
cord-302047-vv5gpldi	124	35	replicate	replicate	VBP
cord-302047-vv5gpldi	124	36	at	at	IN
cord-302047-vv5gpldi	124	37	the	the	DT
cord-302047-vv5gpldi	124	38	expense	expense	NN
cord-302047-vv5gpldi	124	39	of	of	IN
cord-302047-vv5gpldi	124	40	the	the	DT
cord-302047-vv5gpldi	124	41	full	full	JJ
cord-302047-vv5gpldi	124	42	-	-	HYPH
cord-302047-vv5gpldi	124	43	length	length	NN
cord-302047-vv5gpldi	124	44	genome	genome	NN
cord-302047-vv5gpldi	124	45	.	.	.
cord-302047-vv5gpldi	125	1	These	these	DT
cord-302047-vv5gpldi	125	2	subgenomic	subgenomic	NNP
cord-302047-vv5gpldi	125	3	DNAs	dna	NNS
cord-302047-vv5gpldi	125	4	can	can	MD
cord-302047-vv5gpldi	125	5	lead	lead	VB
cord-302047-vv5gpldi	125	6	to	to	IN
cord-302047-vv5gpldi	125	7	reduced	reduce	VBN
cord-302047-vv5gpldi	125	8	symptom	symptom	NN
cord-302047-vv5gpldi	125	9	severity	severity	NN
cord-302047-vv5gpldi	125	10	in	in	IN
cord-302047-vv5gpldi	125	11	plants	plant	NNS
cord-302047-vv5gpldi	125	12	and	and	CC
cord-302047-vv5gpldi	125	13	thereby	thereby	RB
cord-302047-vv5gpldi	125	14	act	act	VB
cord-302047-vv5gpldi	125	15	as	as	IN
cord-302047-vv5gpldi	125	16	modulators	modulator	NNS
cord-302047-vv5gpldi	125	17	of	of	IN
cord-302047-vv5gpldi	125	18	viral	viral	JJ
cord-302047-vv5gpldi	125	19	pathogenicity	pathogenicity	NN
cord-302047-vv5gpldi	125	20	.	.	.
cord-302047-vv5gpldi	126	1	It	-PRON-	PRP
cord-302047-vv5gpldi	126	2	is	be	VBZ
cord-302047-vv5gpldi	126	3	speculated	speculate	VBN
cord-302047-vv5gpldi	126	4	that	that	IN
cord-302047-vv5gpldi	126	5	the	the	DT
cord-302047-vv5gpldi	126	6	(	(	-LRB-
cord-302047-vv5gpldi	126	7	sometimes	sometimes	RB
cord-302047-vv5gpldi	126	8	stepwise	stepwise	JJ
cord-302047-vv5gpldi	126	9	)	)	-RRB-
cord-302047-vv5gpldi	126	10	deletion	deletion	NN
cord-302047-vv5gpldi	126	11	process	process	NN
cord-302047-vv5gpldi	126	12	leading	lead	VBG
cord-302047-vv5gpldi	126	13	to	to	IN
cord-302047-vv5gpldi	126	14	subgenomic	subgenomic	NNP
cord-302047-vv5gpldi	126	15	DNAs	DNAs	NNPS
cord-302047-vv5gpldi	126	16	can	can	MD
cord-302047-vv5gpldi	126	17	also	also	RB
cord-302047-vv5gpldi	126	18	be	be	VB
cord-302047-vv5gpldi	126	19	the	the	DT
cord-302047-vv5gpldi	126	20	process	process	NN
cord-302047-vv5gpldi	126	21	leading	lead	VBG
cord-302047-vv5gpldi	126	22	to	to	IN
cord-302047-vv5gpldi	126	23	the	the	DT
cord-302047-vv5gpldi	126	24	reversion	reversion	NN
cord-302047-vv5gpldi	126	25	to	to	IN
cord-302047-vv5gpldi	126	26	wild	wild	JJ
cord-302047-vv5gpldi	126	27	-	-	HYPH
cord-302047-vv5gpldi	126	28	type	type	NN
cord-302047-vv5gpldi	126	29	full	full	JJ
cord-302047-vv5gpldi	126	30	-	-	HYPH
cord-302047-vv5gpldi	126	31	length	length	NN
cord-302047-vv5gpldi	126	32	DNA	dna	NN
cord-302047-vv5gpldi	126	33	molecules	molecule	NNS
cord-302047-vv5gpldi	126	34	with	with	IN
cord-302047-vv5gpldi	126	35	either	either	DT
cord-302047-vv5gpldi	126	36	insertions	insertion	NNS
cord-302047-vv5gpldi	126	37	or	or	CC
cord-302047-vv5gpldi	126	38	deletions	deletion	NNS
cord-302047-vv5gpldi	126	39	that	that	WDT
cord-302047-vv5gpldi	126	40	make	make	VBP
cord-302047-vv5gpldi	126	41	these	these	DT
cord-302047-vv5gpldi	126	42	bigger	big	JJR
cord-302047-vv5gpldi	126	43	or	or	CC
cord-302047-vv5gpldi	126	44	smaller	small	JJR
cord-302047-vv5gpldi	126	45	than	than	IN
cord-302047-vv5gpldi	126	46	the	the	DT
cord-302047-vv5gpldi	126	47	wild	wild	JJ
cord-302047-vv5gpldi	126	48	-	-	HYPH
cord-302047-vv5gpldi	126	49	type	type	NN
cord-302047-vv5gpldi	126	50	genome	genome	NN
cord-302047-vv5gpldi	126	51	(	(	-LRB-
cord-302047-vv5gpldi	126	52	Martin	Martin	NNP
cord-302047-vv5gpldi	126	53	et	et	NNP
cord-302047-vv5gpldi	126	54	al	al	NNP
cord-302047-vv5gpldi	126	55	.	.	NNP
cord-302047-vv5gpldi	126	56	2011	2011	CD
cord-302047-vv5gpldi	126	57	)	)	-RRB-
cord-302047-vv5gpldi	126	58	.	.	.
cord-302047-vv5gpldi	127	1	When	when	WRB
cord-302047-vv5gpldi	127	2	inserting	insert	VBG
cord-302047-vv5gpldi	127	3	sequences	sequence	NNS
cord-302047-vv5gpldi	127	4	into	into	IN
cord-302047-vv5gpldi	127	5	the	the	DT
cord-302047-vv5gpldi	127	6	genome	genome	NN
cord-302047-vv5gpldi	127	7	of	of	IN
cord-302047-vv5gpldi	127	8	maize	maize	NN
cord-302047-vv5gpldi	127	9	streak	streak	NN
cord-302047-vv5gpldi	127	10	virus	virus	NN
cord-302047-vv5gpldi	127	11	(	(	-LRB-
cord-302047-vv5gpldi	127	12	MSV	MSV	NNP
cord-302047-vv5gpldi	127	13	,	,	,
cord-302047-vv5gpldi	127	14	Geminiviridae	Geminiviridae	NNP
cord-302047-vv5gpldi	127	15	)	)	-RRB-
cord-302047-vv5gpldi	127	16	,	,	,
cord-302047-vv5gpldi	127	17	the	the	DT
cord-302047-vv5gpldi	127	18	infection	infection	NN
cord-302047-vv5gpldi	127	19	efficiency	efficiency	NN
cord-302047-vv5gpldi	127	20	decreased	decrease	VBD
cord-302047-vv5gpldi	127	21	as	as	IN
cord-302047-vv5gpldi	127	22	the	the	DT
cord-302047-vv5gpldi	127	23	size	size	NN
cord-302047-vv5gpldi	127	24	of	of	IN
cord-302047-vv5gpldi	127	25	the	the	DT
cord-302047-vv5gpldi	127	26	insert	insert	NN
cord-302047-vv5gpldi	127	27	increased	increase	VBN
cord-302047-vv5gpldi	127	28	(	(	-LRB-
cord-302047-vv5gpldi	127	29	Shen	Shen	NNP
cord-302047-vv5gpldi	127	30	and	and	CC
cord-302047-vv5gpldi	127	31	Hohn	Hohn	NNP
cord-302047-vv5gpldi	127	32	1991	1991	CD
cord-302047-vv5gpldi	127	33	)	)	-RRB-
cord-302047-vv5gpldi	127	34	.	.	.
cord-302047-vv5gpldi	128	1	Although	although	IN
cord-302047-vv5gpldi	128	2	,	,	,
cord-302047-vv5gpldi	128	3	some	some	DT
cord-302047-vv5gpldi	128	4	of	of	IN
cord-302047-vv5gpldi	128	5	the	the	DT
cord-302047-vv5gpldi	128	6	MSV	MSV	NNP
cord-302047-vv5gpldi	128	7	mutants	mutant	NNS
cord-302047-vv5gpldi	128	8	obtained	obtain	VBD
cord-302047-vv5gpldi	128	9	deletions	deletion	NNS
cord-302047-vv5gpldi	128	10	and	and	CC
cord-302047-vv5gpldi	128	11	reverted	revert	VBN
cord-302047-vv5gpldi	128	12	to	to	IN
cord-302047-vv5gpldi	128	13	the	the	DT
cord-302047-vv5gpldi	128	14	wildtype	wildtype	JJ
cord-302047-vv5gpldi	128	15	length	length	NN
cord-302047-vv5gpldi	128	16	,	,	,
cord-302047-vv5gpldi	128	17	the	the	DT
cord-302047-vv5gpldi	128	18	frequency	frequency	NN
cord-302047-vv5gpldi	128	19	of	of	IN
cord-302047-vv5gpldi	128	20	the	the	DT
cord-302047-vv5gpldi	128	21	deletion	deletion	NN
cord-302047-vv5gpldi	128	22	process	process	NN
cord-302047-vv5gpldi	128	23	did	do	VBD
cord-302047-vv5gpldi	128	24	not	not	RB
cord-302047-vv5gpldi	128	25	increase	increase	VB
cord-302047-vv5gpldi	128	26	linearly	linearly	RB
cord-302047-vv5gpldi	128	27	with	with	IN
cord-302047-vv5gpldi	128	28	the	the	DT
cord-302047-vv5gpldi	128	29	size	size	NN
cord-302047-vv5gpldi	128	30	of	of	IN
cord-302047-vv5gpldi	128	31	the	the	DT
cord-302047-vv5gpldi	128	32	insert	insert	NN
cord-302047-vv5gpldi	128	33	,	,	,
cord-302047-vv5gpldi	128	34	but	but	CC
cord-302047-vv5gpldi	128	35	rather	rather	RB
cord-302047-vv5gpldi	128	36	depended	depend	VBD
cord-302047-vv5gpldi	128	37	on	on	IN
cord-302047-vv5gpldi	128	38	the	the	DT
cord-302047-vv5gpldi	128	39	nature	nature	NN
cord-302047-vv5gpldi	128	40	of	of	IN
cord-302047-vv5gpldi	128	41	the	the	DT
cord-302047-vv5gpldi	128	42	sequence	sequence	NN
cord-302047-vv5gpldi	128	43	(	(	-LRB-
cord-302047-vv5gpldi	128	44	Shen	Shen	NNP
cord-302047-vv5gpldi	128	45	and	and	CC
cord-302047-vv5gpldi	128	46	Hohn	Hohn	NNP
cord-302047-vv5gpldi	128	47	1991	1991	CD
cord-302047-vv5gpldi	128	48	)	)	-RRB-
cord-302047-vv5gpldi	128	49	.	.	.
cord-302047-vv5gpldi	129	1	Deletion	deletion	NN
cord-302047-vv5gpldi	129	2	mutants	mutant	NNS
cord-302047-vv5gpldi	129	3	of	of	IN
cord-302047-vv5gpldi	129	4	the	the	DT
cord-302047-vv5gpldi	129	5	African	african	JJ
cord-302047-vv5gpldi	129	6	cassava	cassava	NN
cord-302047-vv5gpldi	129	7	mosaic	mosaic	NN
cord-302047-vv5gpldi	129	8	virus	virus	NN
cord-302047-vv5gpldi	129	9	(	(	-LRB-
cord-302047-vv5gpldi	129	10	ACMV	ACMV	NNP
cord-302047-vv5gpldi	129	11	)	)	-RRB-
cord-302047-vv5gpldi	129	12	have	have	VBP
cord-302047-vv5gpldi	129	13	also	also	RB
cord-302047-vv5gpldi	129	14	shown	show	VBN
cord-302047-vv5gpldi	129	15	to	to	TO
cord-302047-vv5gpldi	129	16	revert	revert	VB
cord-302047-vv5gpldi	129	17	back	back	RB
cord-302047-vv5gpldi	129	18	to	to	IN
cord-302047-vv5gpldi	129	19	the	the	DT
cord-302047-vv5gpldi	129	20	original	original	JJ
cord-302047-vv5gpldi	129	21	wild	wild	JJ
cord-302047-vv5gpldi	129	22	-	-	HYPH
cord-302047-vv5gpldi	129	23	type	type	NN
cord-302047-vv5gpldi	129	24	genome	genome	NN
cord-302047-vv5gpldi	129	25	length	length	NN
cord-302047-vv5gpldi	129	26	through	through	IN
cord-302047-vv5gpldi	129	27	recombination	recombination	NN
cord-302047-vv5gpldi	129	28	between	between	IN
cord-302047-vv5gpldi	129	29	the	the	DT
cord-302047-vv5gpldi	129	30	two	two	CD
cord-302047-vv5gpldi	129	31	components	component	NNS
cord-302047-vv5gpldi	129	32	of	of	IN
cord-302047-vv5gpldi	129	33	the	the	DT
cord-302047-vv5gpldi	129	34	bipartite	bipartite	JJ
cord-302047-vv5gpldi	129	35	genome	genome	NN
cord-302047-vv5gpldi	129	36	(	(	-LRB-
cord-302047-vv5gpldi	129	37	Etessami	Etessami	NNP
cord-302047-vv5gpldi	129	38	,	,	,
cord-302047-vv5gpldi	129	39	Watts	Watts	NNP
cord-302047-vv5gpldi	129	40	,	,	,
cord-302047-vv5gpldi	129	41	and	and	CC
cord-302047-vv5gpldi	129	42	Stanley	Stanley	NNP
cord-302047-vv5gpldi	129	43	1989	1989	CD
cord-302047-vv5gpldi	129	44	)	)	-RRB-
cord-302047-vv5gpldi	129	45	.	.	.
cord-302047-vv5gpldi	130	1	The	the	DT
cord-302047-vv5gpldi	130	2	selection	selection	NN
cord-302047-vv5gpldi	130	3	pressure	pressure	NN
cord-302047-vv5gpldi	130	4	on	on	IN
cord-302047-vv5gpldi	130	5	the	the	DT
cord-302047-vv5gpldi	130	6	reversion	reversion	NN
cord-302047-vv5gpldi	130	7	to	to	IN
cord-302047-vv5gpldi	130	8	wild	wild	JJ
cord-302047-vv5gpldi	130	9	-	-	HYPH
cord-302047-vv5gpldi	130	10	type	type	NN
cord-302047-vv5gpldi	130	11	genome	genome	NN
cord-302047-vv5gpldi	130	12	length	length	NN
cord-302047-vv5gpldi	130	13	is	be	VBZ
cord-302047-vv5gpldi	130	14	probably	probably	RB
cord-302047-vv5gpldi	130	15	a	a	DT
cord-302047-vv5gpldi	130	16	strong	strong	JJ
cord-302047-vv5gpldi	130	17	size	size	NN
cord-302047-vv5gpldi	130	18	constraint	constraint	NN
cord-302047-vv5gpldi	130	19	on	on	IN
cord-302047-vv5gpldi	130	20	encapsidation	encapsidation	NN
cord-302047-vv5gpldi	130	21	,	,	,
cord-302047-vv5gpldi	130	22	where	where	WRB
cord-302047-vv5gpldi	130	23	in	in	IN
cord-302047-vv5gpldi	130	24	the	the	DT
cord-302047-vv5gpldi	130	25	case	case	NN
cord-302047-vv5gpldi	130	26	of	of	IN
cord-302047-vv5gpldi	130	27	ACMV	ACMV	NNP
cord-302047-vv5gpldi	130	28	the	the	DT
cord-302047-vv5gpldi	130	29	size	size	NN
cord-302047-vv5gpldi	130	30	of	of	IN
cord-302047-vv5gpldi	130	31	encapsidated	encapsidate	VBN
cord-302047-vv5gpldi	130	32	DNA	DNA	NNP
cord-302047-vv5gpldi	130	33	determines	determine	VBZ
cord-302047-vv5gpldi	130	34	the	the	DT
cord-302047-vv5gpldi	130	35	multiplicity	multiplicity	NN
cord-302047-vv5gpldi	130	36	of	of	IN
cord-302047-vv5gpldi	130	37	geminivirus	geminivirus	NNP
cord-302047-vv5gpldi	130	38	particles	particle	NNS
cord-302047-vv5gpldi	130	39	(	(	-LRB-
cord-302047-vv5gpldi	130	40	Frischmuth	Frischmuth	NNP
cord-302047-vv5gpldi	130	41	,	,	,
cord-302047-vv5gpldi	130	42	Ringel	Ringel	NNP
cord-302047-vv5gpldi	130	43	,	,	,
cord-302047-vv5gpldi	130	44	and	and	CC
cord-302047-vv5gpldi	130	45	Kocher	Kocher	NNP
cord-302047-vv5gpldi	130	46	2001	2001	CD
cord-302047-vv5gpldi	130	47	)	)	-RRB-
cord-302047-vv5gpldi	130	48	.	.	.
cord-302047-vv5gpldi	131	1	The	the	DT
cord-302047-vv5gpldi	131	2	Nanoviridae	Nanoviridae	NNP
cord-302047-vv5gpldi	131	3	family	family	NN
cord-302047-vv5gpldi	131	4	includes	include	VBZ
cord-302047-vv5gpldi	131	5	ssDNA	ssDNA	VBG
cord-302047-vv5gpldi	131	6	viruses	virus	NNS
cord-302047-vv5gpldi	131	7	with	with	IN
cord-302047-vv5gpldi	131	8	a	a	DT
cord-302047-vv5gpldi	131	9	multipartite	multipartite	NNP
cord-302047-vv5gpldi	131	10	genome	genome	NN
cord-302047-vv5gpldi	131	11	that	that	WDT
cord-302047-vv5gpldi	131	12	are	be	VBP
cord-302047-vv5gpldi	131	13	composed	compose	VBN
cord-302047-vv5gpldi	131	14	of	of	IN
cord-302047-vv5gpldi	131	15	six	six	CD
cord-302047-vv5gpldi	131	16	to	to	TO
cord-302047-vv5gpldi	131	17	eight	eight	CD
cord-302047-vv5gpldi	131	18	circular	circular	JJ
cord-302047-vv5gpldi	131	19	segments	segment	NNS
cord-302047-vv5gpldi	131	20	.	.	.
cord-302047-vv5gpldi	132	1	Segmented	segmented	JJ
cord-302047-vv5gpldi	132	2	ssDNA	ssdna	RB
cord-302047-vv5gpldi	132	3	viruses	virus	NNS
cord-302047-vv5gpldi	132	4	present	present	VBP
cord-302047-vv5gpldi	132	5	unique	unique	JJ
cord-302047-vv5gpldi	132	6	challenges	challenge	NNS
cord-302047-vv5gpldi	132	7	when	when	WRB
cord-302047-vv5gpldi	132	8	thinking	think	VBG
cord-302047-vv5gpldi	132	9	about	about	IN
cord-302047-vv5gpldi	132	10	the	the	DT
cord-302047-vv5gpldi	132	11	stability	stability	NN
cord-302047-vv5gpldi	132	12	of	of	IN
cord-302047-vv5gpldi	132	13	inserted	insert	VBN
cord-302047-vv5gpldi	132	14	sequences	sequence	NNS
cord-302047-vv5gpldi	132	15	,	,	,
cord-302047-vv5gpldi	132	16	because	because	IN
cord-302047-vv5gpldi	132	17	the	the	DT
cord-302047-vv5gpldi	132	18	frequency	frequency	NN
cord-302047-vv5gpldi	132	19	of	of	IN
cord-302047-vv5gpldi	132	20	genomic	genomic	JJ
cord-302047-vv5gpldi	132	21	segments	segment	NNS
cord-302047-vv5gpldi	132	22	is	be	VBZ
cord-302047-vv5gpldi	132	23	highly	highly	RB
cord-302047-vv5gpldi	132	24	plastic	plastic	JJ
cord-302047-vv5gpldi	132	25	for	for	IN
cord-302047-vv5gpldi	132	26	some	some	DT
cord-302047-vv5gpldi	132	27	of	of	IN
cord-302047-vv5gpldi	132	28	these	these	DT
cord-302047-vv5gpldi	132	29	viruses	virus	NNS
cord-302047-vv5gpldi	132	30	.	.	.
cord-302047-vv5gpldi	133	1	These	these	DT
cord-302047-vv5gpldi	133	2	viruses	virus	NNS
cord-302047-vv5gpldi	133	3	might	may	MD
cord-302047-vv5gpldi	133	4	therefore	therefore	RB
cord-302047-vv5gpldi	133	5	downregulate	downregulate	VB
cord-302047-vv5gpldi	133	6	segments	segment	NNS
cord-302047-vv5gpldi	133	7	for	for	IN
cord-302047-vv5gpldi	133	8	expression	expression	NN
cord-302047-vv5gpldi	133	9	of	of	IN
cord-302047-vv5gpldi	133	10	the	the	DT
cord-302047-vv5gpldi	133	11	inserted	insert	VBN
cord-302047-vv5gpldi	133	12	sequence	sequence	NN
cord-302047-vv5gpldi	133	13	,	,	,
cord-302047-vv5gpldi	133	14	even	even	RB
cord-302047-vv5gpldi	133	15	if	if	IN
cord-302047-vv5gpldi	133	16	downregulation	downregulation	NN
cord-302047-vv5gpldi	133	17	of	of	IN
cord-302047-vv5gpldi	133	18	co	co	JJ
cord-302047-vv5gpldi	133	19	-	-	JJ
cord-302047-vv5gpldi	133	20	localized	localized	JJ
cord-302047-vv5gpldi	133	21	homologous	homologous	JJ
cord-302047-vv5gpldi	133	22	genes	gene	NNS
cord-302047-vv5gpldi	133	23	is	be	VBZ
cord-302047-vv5gpldi	133	24	costly	costly	JJ
cord-302047-vv5gpldi	133	25	.	.	.
cord-302047-vv5gpldi	134	1	A	a	DT
cord-302047-vv5gpldi	134	2	lower	low	JJR
cord-302047-vv5gpldi	134	3	frequency	frequency	NN
cord-302047-vv5gpldi	134	4	would	would	MD
cord-302047-vv5gpldi	134	5	also	also	RB
cord-302047-vv5gpldi	134	6	entail	entail	VB
cord-302047-vv5gpldi	134	7	a	a	DT
cord-302047-vv5gpldi	134	8	lower	low	JJR
cord-302047-vv5gpldi	134	9	mutational	mutational	JJ
cord-302047-vv5gpldi	134	10	supply	supply	NN
cord-302047-vv5gpldi	134	11	,	,	,
cord-302047-vv5gpldi	134	12	limiting	limit	VBG
cord-302047-vv5gpldi	134	13	evolvability	evolvability	NN
cord-302047-vv5gpldi	134	14	,	,	,
cord-302047-vv5gpldi	134	15	the	the	DT
cord-302047-vv5gpldi	134	16	capacity	capacity	NN
cord-302047-vv5gpldi	134	17	of	of	IN
cord-302047-vv5gpldi	134	18	the	the	DT
cord-302047-vv5gpldi	134	19	virus	virus	NN
cord-302047-vv5gpldi	134	20	to	to	TO
cord-302047-vv5gpldi	134	21	generate	generate	VB
cord-302047-vv5gpldi	134	22	beneficial	beneficial	JJ
cord-302047-vv5gpldi	134	23	variation	variation	NN
cord-302047-vv5gpldi	134	24	and	and	CC
cord-302047-vv5gpldi	134	25	subsequently	subsequently	RB
cord-302047-vv5gpldi	134	26	adapt	adapt	VB
cord-302047-vv5gpldi	134	27	.	.	.
cord-302047-vv5gpldi	135	1	Segmented	segmented	JJ
cord-302047-vv5gpldi	135	2	viruses	virus	NNS
cord-302047-vv5gpldi	135	3	might	may	MD
cord-302047-vv5gpldi	135	4	therefore	therefore	RB
cord-302047-vv5gpldi	135	5	display	display	VB
cord-302047-vv5gpldi	135	6	rapid	rapid	JJ
cord-302047-vv5gpldi	135	7	adaptive	adaptive	JJ
cord-302047-vv5gpldi	135	8	responses	response	NNS
cord-302047-vv5gpldi	135	9	to	to	IN
cord-302047-vv5gpldi	135	10	inserted	insert	VBN
cord-302047-vv5gpldi	135	11	sequences	sequence	NNS
cord-302047-vv5gpldi	135	12	,	,	,
cord-302047-vv5gpldi	135	13	whilst	whilst	IN
cord-302047-vv5gpldi	135	14	simultaneously	simultaneously	RB
cord-302047-vv5gpldi	135	15	limiting	limit	VBG
cord-302047-vv5gpldi	135	16	their	-PRON-	PRP$
cord-302047-vv5gpldi	135	17	potential	potential	NN
cord-302047-vv5gpldi	135	18	for	for	IN
cord-302047-vv5gpldi	135	19	longer	long	JJR
cord-302047-vv5gpldi	135	20	-	-	HYPH
cord-302047-vv5gpldi	135	21	term	term	NN
cord-302047-vv5gpldi	135	22	evolution	evolution	NN
cord-302047-vv5gpldi	135	23	.	.	.
cord-302047-vv5gpldi	136	1	To	to	IN
cord-302047-vv5gpldi	136	2	the	the	DT
cord-302047-vv5gpldi	136	3	best	good	JJS
cord-302047-vv5gpldi	136	4	of	of	IN
cord-302047-vv5gpldi	136	5	our	-PRON-	PRP$
cord-302047-vv5gpldi	136	6	knowledge	knowledge	NN
cord-302047-vv5gpldi	136	7	,	,	,
cord-302047-vv5gpldi	136	8	this	this	DT
cord-302047-vv5gpldi	136	9	potentially	potentially	RB
cord-302047-vv5gpldi	136	10	interesting	interesting	JJ
cord-302047-vv5gpldi	136	11	tradeoff	tradeoff	NN
cord-302047-vv5gpldi	136	12	has	have	VBZ
cord-302047-vv5gpldi	136	13	not	not	RB
cord-302047-vv5gpldi	136	14	been	be	VBN
cord-302047-vv5gpldi	136	15	shown	show	VBN
cord-302047-vv5gpldi	136	16	.	.	.
cord-302047-vv5gpldi	137	1	Inserted	insert	VBN
cord-302047-vv5gpldi	137	2	sequences	sequence	NNS
cord-302047-vv5gpldi	137	3	can	can	MD
cord-302047-vv5gpldi	137	4	be	be	VB
cord-302047-vv5gpldi	137	5	unstable	unstable	JJ
cord-302047-vv5gpldi	137	6	in	in	IN
cord-302047-vv5gpldi	137	7	ssDNA	ssdna	JJ
cord-302047-vv5gpldi	137	8	phages	phage	NNS
cord-302047-vv5gpldi	137	9	,	,	,
cord-302047-vv5gpldi	137	10	which	which	WDT
cord-302047-vv5gpldi	137	11	like	like	IN
cord-302047-vv5gpldi	137	12	their	-PRON-	PRP$
cord-302047-vv5gpldi	137	13	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	137	14	counterparts	counterpart	NNS
cord-302047-vv5gpldi	137	15	also	also	RB
cord-302047-vv5gpldi	137	16	can	can	MD
cord-302047-vv5gpldi	137	17	have	have	VB
cord-302047-vv5gpldi	137	18	an	an	DT
cord-302047-vv5gpldi	137	19	upper	upper	JJ
cord-302047-vv5gpldi	137	20	limit	limit	NN
cord-302047-vv5gpldi	137	21	to	to	IN
cord-302047-vv5gpldi	137	22	genome	genome	NN
cord-302047-vv5gpldi	137	23	size	size	NN
cord-302047-vv5gpldi	137	24	.	.	.
cord-302047-vv5gpldi	138	1	Inserts	insert	NNS
cord-302047-vv5gpldi	138	2	of	of	IN
cord-302047-vv5gpldi	138	3	up	up	IN
cord-302047-vv5gpldi	138	4	to	to	TO
cord-302047-vv5gpldi	138	5	163	163	CD
cord-302047-vv5gpldi	138	6	bp	bp	NNS
cord-302047-vv5gpldi	138	7	were	be	VBD
cord-302047-vv5gpldi	138	8	stable	stable	JJ
cord-302047-vv5gpldi	138	9	in	in	IN
cord-302047-vv5gpldi	138	10	X174	X174	NNP
cord-302047-vv5gpldi	138	11	,	,	,
cord-302047-vv5gpldi	138	12	despite	despite	IN
cord-302047-vv5gpldi	138	13	markedly	markedly	RB
cord-302047-vv5gpldi	138	14	reducing	reduce	VBG
cord-302047-vv5gpldi	138	15	fitness	fitness	NN
cord-302047-vv5gpldi	138	16	(	(	-LRB-
cord-302047-vv5gpldi	138	17	Russell	Russell	NNP
cord-302047-vv5gpldi	138	18	and	and	CC
cord-302047-vv5gpldi	138	19	Muller	Muller	NNP
cord-302047-vv5gpldi	138	20	1984	1984	CD
cord-302047-vv5gpldi	138	21	)	)	-RRB-
cord-302047-vv5gpldi	138	22	.	.	.
cord-302047-vv5gpldi	139	1	Genomes	genome	NNS
cord-302047-vv5gpldi	139	2	with	with	IN
cord-302047-vv5gpldi	139	3	larger	large	JJR
cord-302047-vv5gpldi	139	4	insertions	insertion	NNS
cord-302047-vv5gpldi	139	5	were	be	VBD
cord-302047-vv5gpldi	139	6	still	still	RB
cord-302047-vv5gpldi	139	7	infectious	infectious	JJ
cord-302047-vv5gpldi	139	8	,	,	,
cord-302047-vv5gpldi	139	9	although	although	IN
cord-302047-vv5gpldi	139	10	the	the	DT
cord-302047-vv5gpldi	139	11	insert	insert	NN
cord-302047-vv5gpldi	139	12	was	be	VBD
cord-302047-vv5gpldi	139	13	then	then	RB
cord-302047-vv5gpldi	139	14	rapidly	rapidly	RB
cord-302047-vv5gpldi	139	15	lost	lose	VBN
cord-302047-vv5gpldi	139	16	.	.	.
cord-302047-vv5gpldi	140	1	Later	later	RB
cord-302047-vv5gpldi	140	2	,	,	,
cord-302047-vv5gpldi	140	3	it	-PRON-	PRP
cord-302047-vv5gpldi	140	4	was	be	VBD
cord-302047-vv5gpldi	140	5	shown	show	VBN
cord-302047-vv5gpldi	140	6	that	that	IN
cord-302047-vv5gpldi	140	7	short	short	JJ
cord-302047-vv5gpldi	140	8	palindromic	palindromic	JJ
cord-302047-vv5gpldi	140	9	sequences	sequence	NNS
cord-302047-vv5gpldi	140	10	could	could	MD
cord-302047-vv5gpldi	140	11	be	be	VB
cord-302047-vv5gpldi	140	12	inserted	insert	VBN
cord-302047-vv5gpldi	140	13	in	in	IN
cord-302047-vv5gpldi	140	14	X174	X174	NNP
cord-302047-vv5gpldi	140	15	,	,	,
cord-302047-vv5gpldi	140	16	but	but	CC
cord-302047-vv5gpldi	140	17	that	that	IN
cord-302047-vv5gpldi	140	18	these	these	DT
cord-302047-vv5gpldi	140	19	inserts	insert	NNS
cord-302047-vv5gpldi	140	20	become	become	VBP
cord-302047-vv5gpldi	140	21	more	more	RBR
cord-302047-vv5gpldi	140	22	unstable	unstable	JJ
cord-302047-vv5gpldi	140	23	as	as	IN
cord-302047-vv5gpldi	140	24	the	the	DT
cord-302047-vv5gpldi	140	25	number	number	NN
cord-302047-vv5gpldi	140	26	of	of	IN
cord-302047-vv5gpldi	140	27	repeats	repeat	NNS
cord-302047-vv5gpldi	140	28	is	be	VBZ
cord-302047-vv5gpldi	140	29	increased	increase	VBN
cord-302047-vv5gpldi	140	30	and	and	CC
cord-302047-vv5gpldi	140	31	when	when	WRB
cord-302047-vv5gpldi	140	32	the	the	DT
cord-302047-vv5gpldi	140	33	identity	identity	NN
cord-302047-vv5gpldi	140	34	of	of	IN
cord-302047-vv5gpldi	140	35	the	the	DT
cord-302047-vv5gpldi	140	36	repeats	repeat	NNS
cord-302047-vv5gpldi	140	37	is	be	VBZ
cord-302047-vv5gpldi	140	38	identical	identical	JJ
cord-302047-vv5gpldi	140	39	(	(	-LRB-
cord-302047-vv5gpldi	140	40	Williams	Williams	NNP
cord-302047-vv5gpldi	140	41	and	and	CC
cord-302047-vv5gpldi	140	42	Mü	Mü	NNP
cord-302047-vv5gpldi	140	43	ller	ller	NN
cord-302047-vv5gpldi	140	44	1987	1987	CD
cord-302047-vv5gpldi	140	45	)	)	-RRB-
cord-302047-vv5gpldi	140	46	.	.	.
cord-302047-vv5gpldi	141	1	In	in	IN
cord-302047-vv5gpldi	141	2	other	other	JJ
cord-302047-vv5gpldi	141	3	work	work	NN
cord-302047-vv5gpldi	141	4	,	,	,
cord-302047-vv5gpldi	141	5	it	-PRON-	PRP
cord-302047-vv5gpldi	141	6	has	have	VBZ
cord-302047-vv5gpldi	141	7	been	be	VBN
cord-302047-vv5gpldi	141	8	shown	show	VBN
cord-302047-vv5gpldi	141	9	that	that	IN
cord-302047-vv5gpldi	141	10	phage	phage	NN
cord-302047-vv5gpldi	141	11	display	display	NN
cord-302047-vv5gpldi	141	12	(	(	-LRB-
cord-302047-vv5gpldi	141	13	Wu	Wu	NNP
cord-302047-vv5gpldi	141	14	et	et	NNP
cord-302047-vv5gpldi	141	15	al	al	NNP
cord-302047-vv5gpldi	141	16	.	.	.
cord-302047-vv5gpldi	141	17	2016	2016	CD
cord-302047-vv5gpldi	141	18	)	)	-RRB-
cord-302047-vv5gpldi	141	19	can	can	MD
cord-302047-vv5gpldi	141	20	be	be	VB
cord-302047-vv5gpldi	141	21	used	use	VBN
cord-302047-vv5gpldi	141	22	to	to	TO
cord-302047-vv5gpldi	141	23	select	select	VB
cord-302047-vv5gpldi	141	24	clones	clone	NNS
cord-302047-vv5gpldi	141	25	coding	code	VBG
cord-302047-vv5gpldi	141	26	for	for	IN
cord-302047-vv5gpldi	141	27	peptides	peptide	NNS
cord-302047-vv5gpldi	141	28	with	with	IN
cord-302047-vv5gpldi	141	29	high	high	JJ
cord-302047-vv5gpldi	141	30	affinity	affinity	NN
cord-302047-vv5gpldi	141	31	for	for	IN
cord-302047-vv5gpldi	141	32	a	a	DT
cord-302047-vv5gpldi	141	33	particular	particular	JJ
cord-302047-vv5gpldi	141	34	target	target	NN
cord-302047-vv5gpldi	141	35	,	,	,
cord-302047-vv5gpldi	141	36	although	although	IN
cord-302047-vv5gpldi	141	37	selection	selection	NN
cord-302047-vv5gpldi	141	38	for	for	IN
cord-302047-vv5gpldi	141	39	M13	M13	NNP
cord-302047-vv5gpldi	141	40	phages	phage	NNS
cord-302047-vv5gpldi	141	41	with	with	IN
cord-302047-vv5gpldi	141	42	no	no	DT
cord-302047-vv5gpldi	141	43	insert	insert	NN
cord-302047-vv5gpldi	141	44	-	-	HYPH
cord-302047-vv5gpldi	141	45	due	due	JJ
cord-302047-vv5gpldi	141	46	to	to	IN
cord-302047-vv5gpldi	141	47	their	-PRON-	PRP$
cord-302047-vv5gpldi	141	48	presumed	presume	VBN
cord-302047-vv5gpldi	141	49	faster	fast	JJR
cord-302047-vv5gpldi	141	50	replication	replication	NN
cord-302047-vv5gpldi	141	51	-	-	,
cord-302047-vv5gpldi	141	52	can	can	MD
cord-302047-vv5gpldi	141	53	hamper	hamper	VB
cord-302047-vv5gpldi	141	54	'	'	''
cord-302047-vv5gpldi	141	55	phage	phage	NN
cord-302047-vv5gpldi	141	56	panning	panning	NN
cord-302047-vv5gpldi	141	57	'	'	''
cord-302047-vv5gpldi	141	58	(	(	-LRB-
cord-302047-vv5gpldi	141	59	Tur	Tur	NNP
cord-302047-vv5gpldi	141	60	et	et	FW
cord-302047-vv5gpldi	141	61	al	al	NNP
cord-302047-vv5gpldi	141	62	.	.	NNP
cord-302047-vv5gpldi	141	63	2001	2001	CD
cord-302047-vv5gpldi	141	64	)	)	-RRB-
cord-302047-vv5gpldi	141	65	.	.	.
cord-302047-vv5gpldi	142	1	Based	base	VBN
cord-302047-vv5gpldi	142	2	on	on	IN
cord-302047-vv5gpldi	142	3	the	the	DT
cord-302047-vv5gpldi	142	4	little	little	JJ
cord-302047-vv5gpldi	142	5	evidence	evidence	NN
cord-302047-vv5gpldi	142	6	we	-PRON-	PRP
cord-302047-vv5gpldi	142	7	obtained	obtain	VBD
cord-302047-vv5gpldi	142	8	there	there	RB
cord-302047-vv5gpldi	142	9	appears	appear	VBZ
cord-302047-vv5gpldi	142	10	to	to	TO
cord-302047-vv5gpldi	142	11	be	be	VB
cord-302047-vv5gpldi	142	12	strong	strong	JJ
cord-302047-vv5gpldi	142	13	selection	selection	NN
cord-302047-vv5gpldi	142	14	for	for	IN
cord-302047-vv5gpldi	142	15	genome	genome	NN
cord-302047-vv5gpldi	142	16	streamlining	streamlining	NN
cord-302047-vv5gpldi	142	17	in	in	IN
cord-302047-vv5gpldi	142	18	ssDNA	ssdna	JJ
cord-302047-vv5gpldi	142	19	viruses	virus	NNS
cord-302047-vv5gpldi	142	20	.	.	.
cord-302047-vv5gpldi	143	1	After	after	IN
cord-302047-vv5gpldi	143	2	a	a	DT
cord-302047-vv5gpldi	143	3	sequence	sequence	NN
cord-302047-vv5gpldi	143	4	insertion	insertion	NN
cord-302047-vv5gpldi	143	5	,	,	,
cord-302047-vv5gpldi	143	6	reversion	reversion	NN
cord-302047-vv5gpldi	143	7	to	to	IN
cord-302047-vv5gpldi	143	8	the	the	DT
cord-302047-vv5gpldi	143	9	wild	wild	JJ
cord-302047-vv5gpldi	143	10	-	-	HYPH
cord-302047-vv5gpldi	143	11	type	type	NN
cord-302047-vv5gpldi	143	12	genome	genome	NN
cord-302047-vv5gpldi	143	13	size	size	NN
cord-302047-vv5gpldi	143	14	is	be	VBZ
cord-302047-vv5gpldi	143	15	observed	observe	VBN
cord-302047-vv5gpldi	143	16	in	in	IN
cord-302047-vv5gpldi	143	17	both	both	CC
cord-302047-vv5gpldi	143	18	natural	natural	JJ
cord-302047-vv5gpldi	143	19	and	and	CC
cord-302047-vv5gpldi	143	20	laboratory	laboratory	NN
cord-302047-vv5gpldi	143	21	conditions	condition	NNS
cord-302047-vv5gpldi	143	22	.	.	.
cord-302047-vv5gpldi	144	1	Interestingly	interestingly	RB
cord-302047-vv5gpldi	144	2	,	,	,
cord-302047-vv5gpldi	144	3	the	the	DT
cord-302047-vv5gpldi	144	4	nature	nature	NN
cord-302047-vv5gpldi	144	5	of	of	IN
cord-302047-vv5gpldi	144	6	the	the	DT
cord-302047-vv5gpldi	144	7	insert	insert	NN
cord-302047-vv5gpldi	144	8	appears	appear	VBZ
cord-302047-vv5gpldi	144	9	to	to	TO
cord-302047-vv5gpldi	144	10	be	be	VB
cord-302047-vv5gpldi	144	11	more	more	RBR
cord-302047-vv5gpldi	144	12	important	important	JJ
cord-302047-vv5gpldi	144	13	than	than	IN
cord-302047-vv5gpldi	144	14	the	the	DT
cord-302047-vv5gpldi	144	15	size	size	NN
cord-302047-vv5gpldi	144	16	of	of	IN
cord-302047-vv5gpldi	144	17	the	the	DT
cord-302047-vv5gpldi	144	18	insert	insert	NN
cord-302047-vv5gpldi	144	19	,	,	,
cord-302047-vv5gpldi	144	20	indicating	indicate	VBG
cord-302047-vv5gpldi	144	21	that	that	IN
cord-302047-vv5gpldi	144	22	the	the	DT
cord-302047-vv5gpldi	144	23	genomic	genomic	JJ
cord-302047-vv5gpldi	144	24	context	context	NN
cord-302047-vv5gpldi	144	25	also	also	RB
cord-302047-vv5gpldi	144	26	plays	play	VBZ
cord-302047-vv5gpldi	144	27	an	an	DT
cord-302047-vv5gpldi	144	28	important	important	JJ
cord-302047-vv5gpldi	144	29	role	role	NN
cord-302047-vv5gpldi	144	30	in	in	IN
cord-302047-vv5gpldi	144	31	the	the	DT
cord-302047-vv5gpldi	144	32	stability	stability	NN
cord-302047-vv5gpldi	144	33	of	of	IN
cord-302047-vv5gpldi	144	34	ssDNA	ssdna	NN
cord-302047-vv5gpldi	144	35	viruses	virus	NNS
cord-302047-vv5gpldi	144	36	.	.	.
cord-302047-vv5gpldi	145	1	The	the	DT
cord-302047-vv5gpldi	145	2	dsRNA	dsrna	NN
cord-302047-vv5gpldi	145	3	viruses	virus	NNS
cord-302047-vv5gpldi	145	4	have	have	VBP
cord-302047-vv5gpldi	145	5	a	a	DT
cord-302047-vv5gpldi	145	6	range	range	NN
cord-302047-vv5gpldi	145	7	of	of	IN
cord-302047-vv5gpldi	145	8	genome	genome	NN
cord-302047-vv5gpldi	145	9	sizes	size	NNS
cord-302047-vv5gpldi	145	10	(	(	-LRB-
cord-302047-vv5gpldi	145	11	3.7	3.7	CD
cord-302047-vv5gpldi	145	12	-	-	SYM
cord-302047-vv5gpldi	145	13	30.5	30.5	CD
cord-302047-vv5gpldi	145	14	kb	kb	NNP
cord-302047-vv5gpldi	145	15	)	)	-RRB-
cord-302047-vv5gpldi	145	16	that	that	WDT
cord-302047-vv5gpldi	145	17	is	be	VBZ
cord-302047-vv5gpldi	145	18	similar	similar	JJ
cord-302047-vv5gpldi	145	19	to	to	IN
cord-302047-vv5gpldi	145	20	the	the	DT
cord-302047-vv5gpldi	145	21	ssDNA	ssdna	NN
cord-302047-vv5gpldi	145	22	viruses	virus	NNS
cord-302047-vv5gpldi	145	23	.	.	.
cord-302047-vv5gpldi	146	1	Most	Most	JJS
cord-302047-vv5gpldi	146	2	of	of	IN
cord-302047-vv5gpldi	146	3	the	the	DT
cord-302047-vv5gpldi	146	4	dsRNA	dsrna	NN
cord-302047-vv5gpldi	146	5	viruses	virus	NNS
cord-302047-vv5gpldi	146	6	contain	contain	VBP
cord-302047-vv5gpldi	146	7	segmented	segmented	JJ
cord-302047-vv5gpldi	146	8	genomes	genome	NNS
cord-302047-vv5gpldi	146	9	,	,	,
cord-302047-vv5gpldi	146	10	where	where	WRB
cord-302047-vv5gpldi	146	11	during	during	IN
cord-302047-vv5gpldi	146	12	replication	replication	NN
cord-302047-vv5gpldi	146	13	,	,	,
cord-302047-vv5gpldi	146	14	positivesense	positivesense	NN
cord-302047-vv5gpldi	146	15	ssRNAs	ssRNAs	NNP
cord-302047-vv5gpldi	146	16	are	be	VBP
cord-302047-vv5gpldi	146	17	packaged	package	VBN
cord-302047-vv5gpldi	146	18	into	into	IN
cord-302047-vv5gpldi	146	19	procapsids	procapsid	NNS
cord-302047-vv5gpldi	146	20	and	and	CC
cord-302047-vv5gpldi	146	21	serve	serve	VBP
cord-302047-vv5gpldi	146	22	as	as	IN
cord-302047-vv5gpldi	146	23	templates	template	NNS
cord-302047-vv5gpldi	146	24	for	for	IN
cord-302047-vv5gpldi	146	25	dsRNA	dsrna	NN
cord-302047-vv5gpldi	146	26	synthesis	synthesis	NN
cord-302047-vv5gpldi	146	27	.	.	.
cord-302047-vv5gpldi	147	1	Thus	thus	RB
cord-302047-vv5gpldi	147	2	,	,	,
cord-302047-vv5gpldi	147	3	the	the	DT
cord-302047-vv5gpldi	147	4	progeny	progeny	NN
cord-302047-vv5gpldi	147	5	particles	particle	NNS
cord-302047-vv5gpldi	147	6	contain	contain	VBP
cord-302047-vv5gpldi	147	7	a	a	DT
cord-302047-vv5gpldi	147	8	complete	complete	JJ
cord-302047-vv5gpldi	147	9	set	set	NN
cord-302047-vv5gpldi	147	10	of	of	IN
cord-302047-vv5gpldi	147	11	equimolar	equimolar	JJ
cord-302047-vv5gpldi	147	12	genome	genome	NN
cord-302047-vv5gpldi	147	13	segments	segment	NNS
cord-302047-vv5gpldi	147	14	.	.	.
cord-302047-vv5gpldi	148	1	Proper	proper	JJ
cord-302047-vv5gpldi	148	2	recognition	recognition	NN
cord-302047-vv5gpldi	148	3	and	and	CC
cord-302047-vv5gpldi	148	4	stoichiometrical	stoichiometrical	NNP
cord-302047-vv5gpldi	148	5	packaging	packaging	NN
cord-302047-vv5gpldi	148	6	of	of	IN
cord-302047-vv5gpldi	148	7	the	the	DT
cord-302047-vv5gpldi	148	8	ssRNAs	ssRNAs	NNP
cord-302047-vv5gpldi	148	9	is	be	VBZ
cord-302047-vv5gpldi	148	10	indispensable	indispensable	JJ
cord-302047-vv5gpldi	148	11	for	for	IN
cord-302047-vv5gpldi	148	12	multi	multi	JJ
cord-302047-vv5gpldi	148	13	-	-	JJ
cord-302047-vv5gpldi	148	14	segmented	segmented	JJ
cord-302047-vv5gpldi	148	15	genome	genome	NN
cord-302047-vv5gpldi	148	16	assembly	assembly	NN
cord-302047-vv5gpldi	148	17	.	.	.
cord-302047-vv5gpldi	149	1	Although	although	IN
cord-302047-vv5gpldi	149	2	,	,	,
cord-302047-vv5gpldi	149	3	different	different	JJ
cord-302047-vv5gpldi	149	4	dsRNA	dsrna	NN
cord-302047-vv5gpldi	149	5	viruses	virus	NNS
cord-302047-vv5gpldi	149	6	employ	employ	VBP
cord-302047-vv5gpldi	149	7	different	different	JJ
cord-302047-vv5gpldi	149	8	mechanisms	mechanism	NNS
cord-302047-vv5gpldi	149	9	for	for	IN
cord-302047-vv5gpldi	149	10	this	this	DT
cord-302047-vv5gpldi	149	11	assembly	assembly	NN
cord-302047-vv5gpldi	149	12	,	,	,
cord-302047-vv5gpldi	149	13	these	these	DT
cord-302047-vv5gpldi	149	14	all	all	DT
cord-302047-vv5gpldi	149	15	rely	rely	VBP
cord-302047-vv5gpldi	149	16	on	on	IN
cord-302047-vv5gpldi	149	17	proper	proper	JJ
cord-302047-vv5gpldi	149	18	recognition	recognition	NN
cord-302047-vv5gpldi	149	19	of	of	IN
cord-302047-vv5gpldi	149	20	the	the	DT
cord-302047-vv5gpldi	149	21	ssRNAs	ssRNAs	NNP
cord-302047-vv5gpldi	149	22	in	in	IN
cord-302047-vv5gpldi	149	23	either	either	DT
cord-302047-vv5gpldi	149	24	specific	specific	JJ
cord-302047-vv5gpldi	149	25	RNA	rna	NN
cord-302047-vv5gpldi	149	26	-	-	HYPH
cord-302047-vv5gpldi	149	27	protein	protein	NN
cord-302047-vv5gpldi	149	28	or	or	CC
cord-302047-vv5gpldi	149	29	RNA	RNA	NNP
cord-302047-vv5gpldi	149	30	-	-	HYPH
cord-302047-vv5gpldi	149	31	RNA	RNA	NNP
cord-302047-vv5gpldi	149	32	interactions	interaction	NNS
cord-302047-vv5gpldi	149	33	(	(	-LRB-
cord-302047-vv5gpldi	149	34	Borodavka	Borodavka	NNP
cord-302047-vv5gpldi	149	35	,	,	,
cord-302047-vv5gpldi	149	36	Desselberger	Desselberger	NNP
cord-302047-vv5gpldi	149	37	,	,	,
cord-302047-vv5gpldi	149	38	and	and	CC
cord-302047-vv5gpldi	149	39	Patton	Patton	NNP
cord-302047-vv5gpldi	149	40	2018	2018	CD
cord-302047-vv5gpldi	149	41	)	)	-RRB-
cord-302047-vv5gpldi	149	42	.	.	.
cord-302047-vv5gpldi	150	1	We	-PRON-	PRP
cord-302047-vv5gpldi	150	2	therefore	therefore	RB
cord-302047-vv5gpldi	150	3	expect	expect	VBP
cord-302047-vv5gpldi	150	4	that	that	IN
cord-302047-vv5gpldi	150	5	dsRNA	dsrna	NN
cord-302047-vv5gpldi	150	6	virus	virus	NN
cord-302047-vv5gpldi	150	7	genomes	genome	NNS
cord-302047-vv5gpldi	150	8	are	be	VBP
cord-302047-vv5gpldi	150	9	highly	highly	RB
cord-302047-vv5gpldi	150	10	streamlined	streamline	VBN
cord-302047-vv5gpldi	150	11	,	,	,
cord-302047-vv5gpldi	150	12	since	since	IN
cord-302047-vv5gpldi	150	13	most	most	JJS
cord-302047-vv5gpldi	150	14	gene	gene	NN
cord-302047-vv5gpldi	150	15	insertions	insertion	NNS
cord-302047-vv5gpldi	150	16	will	will	MD
cord-302047-vv5gpldi	150	17	probably	probably	RB
cord-302047-vv5gpldi	150	18	disturb	disturb	VB
cord-302047-vv5gpldi	150	19	the	the	DT
cord-302047-vv5gpldi	150	20	recognition	recognition	NN
cord-302047-vv5gpldi	150	21	and	and	CC
cord-302047-vv5gpldi	150	22	packaging	packaging	NN
cord-302047-vv5gpldi	150	23	process	process	NN
cord-302047-vv5gpldi	150	24	of	of	IN
cord-302047-vv5gpldi	150	25	the	the	DT
cord-302047-vv5gpldi	150	26	ssRNAs	ssRNAs	NNP
cord-302047-vv5gpldi	150	27	.	.	.
cord-302047-vv5gpldi	151	1	Interestingly	interestingly	RB
cord-302047-vv5gpldi	151	2	,	,	,
cord-302047-vv5gpldi	151	3	for	for	IN
cord-302047-vv5gpldi	151	4	rotaviruses	rotaviruses	NNP
cord-302047-vv5gpldi	151	5	it	-PRON-	PRP
cord-302047-vv5gpldi	151	6	has	have	VBZ
cord-302047-vv5gpldi	151	7	been	be	VBN
cord-302047-vv5gpldi	151	8	observed	observe	VBN
cord-302047-vv5gpldi	151	9	that	that	IN
cord-302047-vv5gpldi	151	10	genome	genome	NN
cord-302047-vv5gpldi	151	11	segments	segment	NNS
cord-302047-vv5gpldi	151	12	containing	contain	VBG
cord-302047-vv5gpldi	151	13	sequence	sequence	NN
cord-302047-vv5gpldi	151	14	duplications	duplication	NNS
cord-302047-vv5gpldi	151	15	are	be	VBP
cord-302047-vv5gpldi	151	16	preferentially	preferentially	RB
cord-302047-vv5gpldi	151	17	packaged	package	VBN
cord-302047-vv5gpldi	151	18	into	into	IN
cord-302047-vv5gpldi	151	19	progeny	progeny	NN
cord-302047-vv5gpldi	151	20	viruses	virus	NNS
cord-302047-vv5gpldi	151	21	relative	relative	JJ
cord-302047-vv5gpldi	151	22	to	to	IN
cord-302047-vv5gpldi	151	23	wild	wild	JJ
cord-302047-vv5gpldi	151	24	-	-	HYPH
cord-302047-vv5gpldi	151	25	type	type	NN
cord-302047-vv5gpldi	151	26	segments	segment	NNS
cord-302047-vv5gpldi	151	27	(	(	-LRB-
cord-302047-vv5gpldi	151	28	Troupin	Troupin	NNP
cord-302047-vv5gpldi	151	29	et	et	NNP
cord-302047-vv5gpldi	151	30	al	al	NNP
cord-302047-vv5gpldi	151	31	.	.	NNP
cord-302047-vv5gpldi	151	32	2011	2011	CD
cord-302047-vv5gpldi	151	33	)	)	-RRB-
cord-302047-vv5gpldi	151	34	,	,	,
cord-302047-vv5gpldi	151	35	indicating	indicate	VBG
cord-302047-vv5gpldi	151	36	that	that	IN
cord-302047-vv5gpldi	151	37	an	an	DT
cord-302047-vv5gpldi	151	38	increase	increase	NN
cord-302047-vv5gpldi	151	39	in	in	IN
cord-302047-vv5gpldi	151	40	genome	genome	NN
cord-302047-vv5gpldi	151	41	/	/	SYM
cord-302047-vv5gpldi	151	42	segment	segment	NN
cord-302047-vv5gpldi	151	43	size	size	NN
cord-302047-vv5gpldi	151	44	may	may	MD
cord-302047-vv5gpldi	151	45	not	not	RB
cord-302047-vv5gpldi	151	46	be	be	VB
cord-302047-vv5gpldi	151	47	a	a	DT
cord-302047-vv5gpldi	151	48	hard	hard	JJ
cord-302047-vv5gpldi	151	49	constraint	constraint	NN
cord-302047-vv5gpldi	151	50	.	.	.
cord-302047-vv5gpldi	152	1	We	-PRON-	PRP
cord-302047-vv5gpldi	152	2	hypothesize	hypothesize	VBP
cord-302047-vv5gpldi	152	3	that	that	IN
cord-302047-vv5gpldi	152	4	few	few	JJ
cord-302047-vv5gpldi	152	5	if	if	IN
cord-302047-vv5gpldi	152	6	any	any	DT
cord-302047-vv5gpldi	152	7	gene	gene	NN
cord-302047-vv5gpldi	152	8	insertions	insertion	NNS
cord-302047-vv5gpldi	152	9	will	will	MD
cord-302047-vv5gpldi	152	10	lead	lead	VB
cord-302047-vv5gpldi	152	11	to	to	IN
cord-302047-vv5gpldi	152	12	viable	viable	JJ
cord-302047-vv5gpldi	152	13	genomes	genome	NNS
cord-302047-vv5gpldi	152	14	due	due	JJ
cord-302047-vv5gpldi	152	15	to	to	IN
cord-302047-vv5gpldi	152	16	the	the	DT
cord-302047-vv5gpldi	152	17	perturbation	perturbation	NN
cord-302047-vv5gpldi	152	18	of	of	IN
cord-302047-vv5gpldi	152	19	segmented	segmented	JJ
cord-302047-vv5gpldi	152	20	genome	genome	NN
cord-302047-vv5gpldi	152	21	assembly	assembly	NN
cord-302047-vv5gpldi	152	22	into	into	IN
cord-302047-vv5gpldi	152	23	virus	virus	NN
cord-302047-vv5gpldi	152	24	particles	particle	NNS
cord-302047-vv5gpldi	152	25	.	.	.
cord-302047-vv5gpldi	153	1	If	if	IN
cord-302047-vv5gpldi	153	2	a	a	DT
cord-302047-vv5gpldi	153	3	gene	gene	NN
cord-302047-vv5gpldi	153	4	insertion	insertion	NN
cord-302047-vv5gpldi	153	5	happens	happen	VBZ
cord-302047-vv5gpldi	153	6	to	to	TO
cord-302047-vv5gpldi	153	7	be	be	VB
cord-302047-vv5gpldi	153	8	viable	viable	JJ
cord-302047-vv5gpldi	153	9	,	,	,
cord-302047-vv5gpldi	153	10	it	-PRON-	PRP
cord-302047-vv5gpldi	153	11	will	will	MD
cord-302047-vv5gpldi	153	12	probably	probably	RB
cord-302047-vv5gpldi	153	13	be	be	VB
cord-302047-vv5gpldi	153	14	rapidly	rapidly	RB
cord-302047-vv5gpldi	153	15	purged	purge	VBN
cord-302047-vv5gpldi	153	16	from	from	IN
cord-302047-vv5gpldi	153	17	the	the	DT
cord-302047-vv5gpldi	153	18	viral	viral	JJ
cord-302047-vv5gpldi	153	19	genome	genome	NN
cord-302047-vv5gpldi	153	20	.	.	.
cord-302047-vv5gpldi	154	1	One	one	CD
cord-302047-vv5gpldi	154	2	exception	exception	NN
cord-302047-vv5gpldi	154	3	to	to	IN
cord-302047-vv5gpldi	154	4	this	this	DT
cord-302047-vv5gpldi	154	5	hypothesis	hypothesis	NN
cord-302047-vv5gpldi	154	6	could	could	MD
cord-302047-vv5gpldi	154	7	be	be	VB
cord-302047-vv5gpldi	154	8	a	a	DT
cord-302047-vv5gpldi	154	9	gene	gene	NN
cord-302047-vv5gpldi	154	10	insertion	insertion	NN
cord-302047-vv5gpldi	154	11	originating	originate	VBG
cord-302047-vv5gpldi	154	12	from	from	IN
cord-302047-vv5gpldi	154	13	a	a	DT
cord-302047-vv5gpldi	154	14	closely	closely	RB
cord-302047-vv5gpldi	154	15	related	related	JJ
cord-302047-vv5gpldi	154	16	virus	virus	NN
cord-302047-vv5gpldi	154	17	,	,	,
cord-302047-vv5gpldi	154	18	for	for	IN
cord-302047-vv5gpldi	154	19	example	example	NN
cord-302047-vv5gpldi	154	20	a	a	DT
cord-302047-vv5gpldi	154	21	virus	virus	NN
cord-302047-vv5gpldi	154	22	with	with	IN
cord-302047-vv5gpldi	154	23	similar	similar	JJ
cord-302047-vv5gpldi	154	24	packaging	packaging	NN
cord-302047-vv5gpldi	154	25	signals	signal	NNS
cord-302047-vv5gpldi	154	26	,	,	,
cord-302047-vv5gpldi	154	27	leading	lead	VBG
cord-302047-vv5gpldi	154	28	to	to	IN
cord-302047-vv5gpldi	154	29	a	a	DT
cord-302047-vv5gpldi	154	30	fitness	fitness	NN
cord-302047-vv5gpldi	154	31	advantage	advantage	NN
cord-302047-vv5gpldi	154	32	,	,	,
cord-302047-vv5gpldi	154	33	such	such	JJ
cord-302047-vv5gpldi	154	34	as	as	IN
cord-302047-vv5gpldi	154	35	increased	increase	VBN
cord-302047-vv5gpldi	154	36	packaging	packaging	NN
cord-302047-vv5gpldi	154	37	efficiency	efficiency	NN
cord-302047-vv5gpldi	154	38	.	.	.
cord-302047-vv5gpldi	155	1	Only	only	RB
cord-302047-vv5gpldi	155	2	a	a	DT
cord-302047-vv5gpldi	155	3	small	small	JJ
cord-302047-vv5gpldi	155	4	number	number	NN
cord-302047-vv5gpldi	155	5	of	of	IN
cord-302047-vv5gpldi	155	6	studies	study	NNS
cord-302047-vv5gpldi	155	7	that	that	WDT
cord-302047-vv5gpldi	155	8	test	test	VBP
cord-302047-vv5gpldi	155	9	the	the	DT
cord-302047-vv5gpldi	155	10	stability	stability	NN
cord-302047-vv5gpldi	155	11	of	of	IN
cord-302047-vv5gpldi	155	12	inserts	insert	NNS
cord-302047-vv5gpldi	155	13	in	in	IN
cord-302047-vv5gpldi	155	14	dsRNA	dsrna	NN
cord-302047-vv5gpldi	156	1	viruses	virus	NNS
cord-302047-vv5gpldi	156	2	are	be	VBP
cord-302047-vv5gpldi	156	3	available	available	JJ
cord-302047-vv5gpldi	156	4	,	,	,
cord-302047-vv5gpldi	156	5	and	and	CC
cord-302047-vv5gpldi	156	6	these	these	DT
cord-302047-vv5gpldi	156	7	concern	concern	NN
cord-302047-vv5gpldi	156	8	the	the	DT
cord-302047-vv5gpldi	156	9	generation	generation	NN
cord-302047-vv5gpldi	156	10	of	of	IN
cord-302047-vv5gpldi	156	11	recombinant	recombinant	JJ
cord-302047-vv5gpldi	156	12	rotavirus	rotavirus	NN
cord-302047-vv5gpldi	156	13	expressing	express	VBG
cord-302047-vv5gpldi	156	14	foreign	foreign	JJ
cord-302047-vv5gpldi	156	15	genes	gene	NNS
cord-302047-vv5gpldi	156	16	.	.	.
cord-302047-vv5gpldi	157	1	Group	Group	NNP
cord-302047-vv5gpldi	157	2	A	a	DT
cord-302047-vv5gpldi	157	3	rotavirus	rotavirus	NN
cord-302047-vv5gpldi	157	4	,	,	,
cord-302047-vv5gpldi	157	5	consisting	consist	VBG
cord-302047-vv5gpldi	157	6	of	of	IN
cord-302047-vv5gpldi	157	7	eleven	eleven	CD
cord-302047-vv5gpldi	157	8	segments	segment	NNS
cord-302047-vv5gpldi	157	9	,	,	,
cord-302047-vv5gpldi	157	10	has	have	VBZ
cord-302047-vv5gpldi	157	11	been	be	VBN
cord-302047-vv5gpldi	157	12	engineered	engineer	VBN
cord-302047-vv5gpldi	157	13	to	to	TO
cord-302047-vv5gpldi	157	14	express	express	VB
cord-302047-vv5gpldi	157	15	fluorescent	fluorescent	JJ
cord-302047-vv5gpldi	157	16	proteins	protein	NNS
cord-302047-vv5gpldi	157	17	(	(	-LRB-
cord-302047-vv5gpldi	157	18	Kanai	Kanai	NNP
cord-302047-vv5gpldi	157	19	et	et	NNP
cord-302047-vv5gpldi	157	20	al	al	NNP
cord-302047-vv5gpldi	157	21	.	.	.
cord-302047-vv5gpldi	157	22	2017	2017	CD
cord-302047-vv5gpldi	158	1	(	(	-LRB-
cord-302047-vv5gpldi	158	2	Kanai	Kanai	NNP
cord-302047-vv5gpldi	158	3	et	et	NNP
cord-302047-vv5gpldi	158	4	al	al	NNP
cord-302047-vv5gpldi	158	5	.	.	.
cord-302047-vv5gpldi	159	1	,	,	,
cord-302047-vv5gpldi	160	1	2019	2019	CD
cord-302047-vv5gpldi	160	2	Komoto	Komoto	NNP
cord-302047-vv5gpldi	160	3	et	et	NNP
cord-302047-vv5gpldi	160	4	al	al	NNP
cord-302047-vv5gpldi	160	5	.	.	.
cord-302047-vv5gpldi	160	6	2017	2017	CD
cord-302047-vv5gpldi	160	7	)	)	-RRB-
cord-302047-vv5gpldi	160	8	such	such	JJ
cord-302047-vv5gpldi	160	9	as	as	IN
cord-302047-vv5gpldi	160	10	enhanced	enhance	VBN
cord-302047-vv5gpldi	160	11	green	green	JJ
cord-302047-vv5gpldi	160	12	fluorescent	fluorescent	NN
cord-302047-vv5gpldi	160	13	protein	protein	NN
cord-302047-vv5gpldi	160	14	(	(	-LRB-
cord-302047-vv5gpldi	160	15	eGFP	eGFP	NNP
cord-302047-vv5gpldi	160	16	)	)	-RRB-
cord-302047-vv5gpldi	160	17	and	and	CC
cord-302047-vv5gpldi	160	18	mCherry	mCherry	NNP
cord-302047-vv5gpldi	160	19	.	.	.
cord-302047-vv5gpldi	161	1	However	however	RB
cord-302047-vv5gpldi	161	2	,	,	,
cord-302047-vv5gpldi	161	3	segment	segment	NN
cord-302047-vv5gpldi	161	4	5	5	CD
cord-302047-vv5gpldi	161	5	in	in	IN
cord-302047-vv5gpldi	161	6	which	which	WDT
cord-302047-vv5gpldi	161	7	these	these	DT
cord-302047-vv5gpldi	161	8	genes	gene	NNS
cord-302047-vv5gpldi	161	9	were	be	VBD
cord-302047-vv5gpldi	161	10	introduced	introduce	VBN
cord-302047-vv5gpldi	161	11	is	be	VBZ
cord-302047-vv5gpldi	161	12	expressed	express	VBN
cord-302047-vv5gpldi	161	13	at	at	IN
cord-302047-vv5gpldi	161	14	low	low	JJ
cord-302047-vv5gpldi	161	15	levels	level	NNS
cord-302047-vv5gpldi	161	16	and	and	CC
cord-302047-vv5gpldi	161	17	is	be	VBZ
cord-302047-vv5gpldi	161	18	subject	subject	JJ
cord-302047-vv5gpldi	161	19	to	to	IN
cord-302047-vv5gpldi	161	20	proteasomal	proteasomal	JJ
cord-302047-vv5gpldi	161	21	degradation	degradation	NN
cord-302047-vv5gpldi	161	22	(	(	-LRB-
cord-302047-vv5gpldi	161	23	Based	base	VBN
cord-302047-vv5gpldi	161	24	on	on	IN
cord-302047-vv5gpldi	161	25	limited	limited	JJ
cord-302047-vv5gpldi	161	26	evidence	evidence	NN
cord-302047-vv5gpldi	161	27	,	,	,
cord-302047-vv5gpldi	161	28	we	-PRON-	PRP
cord-302047-vv5gpldi	161	29	tentatively	tentatively	RB
cord-302047-vv5gpldi	161	30	conclude	conclude	VBP
cord-302047-vv5gpldi	161	31	that	that	IN
cord-302047-vv5gpldi	161	32	stoichiometric	stoichiometric	JJ
cord-302047-vv5gpldi	161	33	packaging	packaging	NN
cord-302047-vv5gpldi	161	34	of	of	IN
cord-302047-vv5gpldi	161	35	segmented	segmented	JJ
cord-302047-vv5gpldi	161	36	genomes	genome	NNS
cord-302047-vv5gpldi	161	37	may	may	MD
cord-302047-vv5gpldi	161	38	form	form	VB
cord-302047-vv5gpldi	161	39	an	an	DT
cord-302047-vv5gpldi	161	40	impediment	impediment	NN
cord-302047-vv5gpldi	161	41	to	to	IN
cord-302047-vv5gpldi	161	42	engineering	engineering	NN
cord-302047-vv5gpldi	161	43	and	and	CC
cord-302047-vv5gpldi	161	44	insert	insert	VB
cord-302047-vv5gpldi	161	45	stability	stability	NN
cord-302047-vv5gpldi	161	46	.	.	.
cord-302047-vv5gpldi	162	1	However	however	RB
cord-302047-vv5gpldi	162	2	,	,	,
cord-302047-vv5gpldi	162	3	recent	recent	JJ
cord-302047-vv5gpldi	162	4	work	work	NN
cord-302047-vv5gpldi	162	5	also	also	RB
cord-302047-vv5gpldi	162	6	suggests	suggest	VBZ
cord-302047-vv5gpldi	162	7	that	that	IN
cord-302047-vv5gpldi	162	8	careful	careful	JJ
cord-302047-vv5gpldi	162	9	engineering	engineering	NN
cord-302047-vv5gpldi	162	10	of	of	IN
cord-302047-vv5gpldi	162	11	dsRNA	dsrna	NN
cord-302047-vv5gpldi	162	12	viruses	virus	NNS
cord-302047-vv5gpldi	162	13	may	may	MD
cord-302047-vv5gpldi	162	14	lead	lead	VB
cord-302047-vv5gpldi	162	15	to	to	IN
cord-302047-vv5gpldi	162	16	stable	stable	JJ
cord-302047-vv5gpldi	162	17	sequence	sequence	NN
cord-302047-vv5gpldi	162	18	insertions	insertion	NNS
cord-302047-vv5gpldi	162	19	.	.	.
cord-302047-vv5gpldi	163	1	The	the	DT
cord-302047-vv5gpldi	163	2	generality	generality	NN
cord-302047-vv5gpldi	163	3	of	of	IN
cord-302047-vv5gpldi	163	4	these	these	DT
cord-302047-vv5gpldi	163	5	conclusions	conclusion	NNS
cord-302047-vv5gpldi	163	6	for	for	IN
cord-302047-vv5gpldi	163	7	the	the	DT
cord-302047-vv5gpldi	163	8	dsRNA	dsrna	NN
cord-302047-vv5gpldi	163	9	viruses	virus	NNS
cord-302047-vv5gpldi	163	10	,	,	,
cord-302047-vv5gpldi	163	11	and	and	CC
cord-302047-vv5gpldi	163	12	their	-PRON-	PRP$
cord-302047-vv5gpldi	163	13	dependence	dependence	NN
cord-302047-vv5gpldi	163	14	on	on	IN
cord-302047-vv5gpldi	163	15	environmental	environmental	JJ
cord-302047-vv5gpldi	163	16	and	and	CC
cord-302047-vv5gpldi	163	17	demographic	demographic	JJ
cord-302047-vv5gpldi	163	18	conditions	condition	NNS
cord-302047-vv5gpldi	163	19	,	,	,
cord-302047-vv5gpldi	163	20	remain	remain	VBP
cord-302047-vv5gpldi	163	21	to	to	TO
cord-302047-vv5gpldi	163	22	be	be	VB
cord-302047-vv5gpldi	163	23	seen	see	VBN
cord-302047-vv5gpldi	163	24	.	.	.
cord-302047-vv5gpldi	164	1	The	the	DT
cord-302047-vv5gpldi	164	2	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	164	3	)	)	-RRB-
cord-302047-vv5gpldi	164	4	viruses	virus	NNS
cord-302047-vv5gpldi	164	5	range	range	VBP
cord-302047-vv5gpldi	164	6	in	in	IN
cord-302047-vv5gpldi	164	7	genome	genome	NN
cord-302047-vv5gpldi	164	8	size	size	NN
cord-302047-vv5gpldi	164	9	from	from	IN
cord-302047-vv5gpldi	164	10	2.3	2.3	CD
cord-302047-vv5gpldi	164	11	to	to	IN
cord-302047-vv5gpldi	164	12	31	31	CD
cord-302047-vv5gpldi	164	13	kbp	kbp	NNS
cord-302047-vv5gpldi	164	14	.	.	.
cord-302047-vv5gpldi	165	1	It	-PRON-	PRP
cord-302047-vv5gpldi	165	2	has	have	VBZ
cord-302047-vv5gpldi	165	3	been	be	VBN
cord-302047-vv5gpldi	165	4	shown	show	VBN
cord-302047-vv5gpldi	165	5	that	that	IN
cord-302047-vv5gpldi	165	6	both	both	DT
cord-302047-vv5gpldi	165	7	animal	animal	NN
cord-302047-vv5gpldi	165	8	and	and	CC
cord-302047-vv5gpldi	165	9	plant	plant	NN
cord-302047-vv5gpldi	165	10	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	165	11	)	)	-RRB-
cord-302047-vv5gpldi	165	12	viruses	virus	NNS
cord-302047-vv5gpldi	165	13	can	can	MD
cord-302047-vv5gpldi	165	14	express	express	VB
cord-302047-vv5gpldi	165	15	inserted	insert	VBN
cord-302047-vv5gpldi	165	16	foreign	foreign	JJ
cord-302047-vv5gpldi	165	17	genes	gene	NNS
cord-302047-vv5gpldi	165	18	.	.	.
cord-302047-vv5gpldi	166	1	However	however	RB
cord-302047-vv5gpldi	166	2	,	,	,
cord-302047-vv5gpldi	166	3	the	the	DT
cord-302047-vv5gpldi	166	4	nature	nature	NN
cord-302047-vv5gpldi	166	5	of	of	IN
cord-302047-vv5gpldi	166	6	the	the	DT
cord-302047-vv5gpldi	166	7	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	166	8	)	)	-RRB-
cord-302047-vv5gpldi	166	9	genomes	genome	NNS
cord-302047-vv5gpldi	166	10	poses	pose	VBZ
cord-302047-vv5gpldi	166	11	several	several	JJ
cord-302047-vv5gpldi	166	12	limitations	limitation	NNS
cord-302047-vv5gpldi	166	13	to	to	IN
cord-302047-vv5gpldi	166	14	efficient	efficient	JJ
cord-302047-vv5gpldi	166	15	expression	expression	NN
cord-302047-vv5gpldi	166	16	and	and	CC
cord-302047-vv5gpldi	166	17	maintenance	maintenance	NN
cord-302047-vv5gpldi	166	18	of	of	IN
cord-302047-vv5gpldi	166	19	the	the	DT
cord-302047-vv5gpldi	166	20	insert	insert	NN
cord-302047-vv5gpldi	166	21	.	.	.
cord-302047-vv5gpldi	167	1	Most	Most	JJS
cord-302047-vv5gpldi	167	2	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	167	3	)	)	-RRB-
cord-302047-vv5gpldi	167	4	genomes	genome	NNS
cord-302047-vv5gpldi	167	5	used	use	VBN
cord-302047-vv5gpldi	167	6	for	for	IN
cord-302047-vv5gpldi	167	7	the	the	DT
cord-302047-vv5gpldi	167	8	expression	expression	NN
cord-302047-vv5gpldi	167	9	of	of	IN
cord-302047-vv5gpldi	167	10	foreign	foreign	JJ
cord-302047-vv5gpldi	167	11	genes	gene	NNS
cord-302047-vv5gpldi	167	12	code	code	NN
cord-302047-vv5gpldi	167	13	for	for	IN
cord-302047-vv5gpldi	167	14	a	a	DT
cord-302047-vv5gpldi	167	15	polyprotein	polyprotein	NN
cord-302047-vv5gpldi	167	16	,	,	,
cord-302047-vv5gpldi	167	17	a	a	DT
cord-302047-vv5gpldi	167	18	single	single	JJ
cord-302047-vv5gpldi	167	19	ORF	orf	NN
cord-302047-vv5gpldi	167	20	that	that	WDT
cord-302047-vv5gpldi	167	21	is	be	VBZ
cord-302047-vv5gpldi	167	22	further	further	RB
cord-302047-vv5gpldi	167	23	processed	process	VBN
cord-302047-vv5gpldi	167	24	after	after	IN
cord-302047-vv5gpldi	167	25	translation	translation	NN
cord-302047-vv5gpldi	167	26	into	into	IN
cord-302047-vv5gpldi	167	27	different	different	JJ
cord-302047-vv5gpldi	167	28	mature	mature	JJ
cord-302047-vv5gpldi	167	29	peptides	peptide	NNS
cord-302047-vv5gpldi	167	30	.	.	.
cord-302047-vv5gpldi	168	1	The	the	DT
cord-302047-vv5gpldi	168	2	processing	processing	NN
cord-302047-vv5gpldi	168	3	occurs	occur	VBZ
cord-302047-vv5gpldi	168	4	through	through	IN
cord-302047-vv5gpldi	168	5	autocatalytic	autocatalytic	JJ
cord-302047-vv5gpldi	168	6	cleaving	cleaving	NN
cord-302047-vv5gpldi	168	7	at	at	IN
cord-302047-vv5gpldi	168	8	specific	specific	JJ
cord-302047-vv5gpldi	168	9	cleavage	cleavage	NN
cord-302047-vv5gpldi	168	10	sites	site	NNS
cord-302047-vv5gpldi	168	11	located	locate	VBN
cord-302047-vv5gpldi	168	12	between	between	IN
cord-302047-vv5gpldi	168	13	the	the	DT
cord-302047-vv5gpldi	168	14	different	different	JJ
cord-302047-vv5gpldi	168	15	proteins	protein	NNS
cord-302047-vv5gpldi	168	16	to	to	TO
cord-302047-vv5gpldi	168	17	be	be	VB
cord-302047-vv5gpldi	168	18	expressed	express	VBN
cord-302047-vv5gpldi	168	19	.	.	.
cord-302047-vv5gpldi	169	1	Insertions	insertion	NNS
cord-302047-vv5gpldi	169	2	should	should	MD
cord-302047-vv5gpldi	169	3	therefore	therefore	RB
cord-302047-vv5gpldi	169	4	be	be	VB
cord-302047-vv5gpldi	169	5	carefully	carefully	RB
cord-302047-vv5gpldi	169	6	engineered	engineer	VBN
cord-302047-vv5gpldi	169	7	,	,	,
cord-302047-vv5gpldi	169	8	including	include	VBG
cord-302047-vv5gpldi	169	9	proper	proper	JJ
cord-302047-vv5gpldi	169	10	cleavage	cleavage	NN
cord-302047-vv5gpldi	169	11	sites	site	NNS
cord-302047-vv5gpldi	169	12	corresponding	correspond	VBG
cord-302047-vv5gpldi	169	13	to	to	IN
cord-302047-vv5gpldi	169	14	the	the	DT
cord-302047-vv5gpldi	169	15	site	site	NN
cord-302047-vv5gpldi	169	16	of	of	IN
cord-302047-vv5gpldi	169	17	insertion	insertion	NN
cord-302047-vv5gpldi	169	18	.	.	.
cord-302047-vv5gpldi	170	1	Even	even	RB
cord-302047-vv5gpldi	170	2	when	when	WRB
cord-302047-vv5gpldi	170	3	respecting	respect	VBG
cord-302047-vv5gpldi	170	4	these	these	DT
cord-302047-vv5gpldi	170	5	design	design	NN
cord-302047-vv5gpldi	170	6	rules	rule	NNS
cord-302047-vv5gpldi	170	7	,	,	,
cord-302047-vv5gpldi	170	8	inserts	insert	NNS
cord-302047-vv5gpldi	170	9	may	may	MD
cord-302047-vv5gpldi	170	10	impose	impose	VB
cord-302047-vv5gpldi	170	11	restriction	restriction	NN
cord-302047-vv5gpldi	170	12	on	on	IN
cord-302047-vv5gpldi	170	13	viral	viral	JJ
cord-302047-vv5gpldi	170	14	replication	replication	NN
cord-302047-vv5gpldi	170	15	due	due	IN
cord-302047-vv5gpldi	170	16	to	to	IN
cord-302047-vv5gpldi	170	17	the	the	DT
cord-302047-vv5gpldi	170	18	failure	failure	NN
cord-302047-vv5gpldi	170	19	of	of	IN
cord-302047-vv5gpldi	170	20	proper	proper	JJ
cord-302047-vv5gpldi	170	21	protease	protease	NN
cord-302047-vv5gpldi	170	22	cleavage	cleavage	NN
cord-302047-vv5gpldi	170	23	due	due	IN
cord-302047-vv5gpldi	170	24	to	to	IN
cord-302047-vv5gpldi	170	25	conformational	conformational	JJ
cord-302047-vv5gpldi	170	26	constraints	constraint	NNS
cord-302047-vv5gpldi	170	27	.	.	.
cord-302047-vv5gpldi	171	1	In	in	IN
cord-302047-vv5gpldi	171	2	addition	addition	NN
cord-302047-vv5gpldi	171	3	,	,	,
cord-302047-vv5gpldi	171	4	the	the	DT
cord-302047-vv5gpldi	171	5	genomes	genome	NNS
cord-302047-vv5gpldi	171	6	of	of	IN
cord-302047-vv5gpldi	171	7	RNA	RNA	NNP
cord-302047-vv5gpldi	171	8	viruses	virus	NNS
cord-302047-vv5gpldi	171	9	tend	tend	VBP
cord-302047-vv5gpldi	171	10	to	to	TO
cord-302047-vv5gpldi	171	11	be	be	VB
cord-302047-vv5gpldi	171	12	composed	compose	VBN
cord-302047-vv5gpldi	171	13	of	of	IN
cord-302047-vv5gpldi	171	14	overlapping	overlap	VBG
cord-302047-vv5gpldi	171	15	genes	gene	NNS
cord-302047-vv5gpldi	171	16	(	(	-LRB-
cord-302047-vv5gpldi	171	17	Belshaw	Belshaw	NNP
cord-302047-vv5gpldi	171	18	,	,	,
cord-302047-vv5gpldi	171	19	Pybus	Pybus	NNP
cord-302047-vv5gpldi	171	20	,	,	,
cord-302047-vv5gpldi	171	21	and	and	CC
cord-302047-vv5gpldi	171	22	Rambaut	Rambaut	NNP
cord-302047-vv5gpldi	171	23	2007	2007	CD
cord-302047-vv5gpldi	171	24	)	)	-RRB-
cord-302047-vv5gpldi	171	25	,	,	,
cord-302047-vv5gpldi	171	26	which	which	WDT
cord-302047-vv5gpldi	171	27	limits	limit	VBZ
cord-302047-vv5gpldi	171	28	their	-PRON-	PRP$
cord-302047-vv5gpldi	171	29	adaptive	adaptive	JJ
cord-302047-vv5gpldi	171	30	capacity	capacity	NN
cord-302047-vv5gpldi	171	31	(	(	-LRB-
cord-302047-vv5gpldi	171	32	Simon	Simon	NNP
cord-302047-vv5gpldi	171	33	-	-	HYPH
cord-302047-vv5gpldi	171	34	Loriere	Loriere	NNP
cord-302047-vv5gpldi	171	35	,	,	,
cord-302047-vv5gpldi	171	36	Holmes	Holmes	NNP
cord-302047-vv5gpldi	171	37	,	,	,
cord-302047-vv5gpldi	171	38	and	and	CC
cord-302047-vv5gpldi	171	39	Pagá	Pagá	NNP
cord-302047-vv5gpldi	171	40	n	n	NNP
cord-302047-vv5gpldi	171	41	2013	2013	CD
cord-302047-vv5gpldi	171	42	)	)	-RRB-
cord-302047-vv5gpldi	171	43	.	.	.
cord-302047-vv5gpldi	172	1	Overlap	overlap	VB
cord-302047-vv5gpldi	172	2	can	can	MD
cord-302047-vv5gpldi	172	3	form	form	VB
cord-302047-vv5gpldi	172	4	an	an	DT
cord-302047-vv5gpldi	172	5	impediment	impediment	NN
cord-302047-vv5gpldi	172	6	to	to	IN
cord-302047-vv5gpldi	172	7	engineering	engineering	NN
cord-302047-vv5gpldi	172	8	,	,	,
cord-302047-vv5gpldi	172	9	and	and	CC
cord-302047-vv5gpldi	172	10	perhaps	perhaps	RB
cord-302047-vv5gpldi	172	11	to	to	IN
cord-302047-vv5gpldi	172	12	the	the	DT
cord-302047-vv5gpldi	172	13	likelihood	likelihood	NN
cord-302047-vv5gpldi	172	14	an	an	DT
cord-302047-vv5gpldi	172	15	inserted	insert	VBN
cord-302047-vv5gpldi	172	16	sequence	sequence	NN
cord-302047-vv5gpldi	172	17	is	be	VBZ
cord-302047-vv5gpldi	172	18	maintained	maintain	VBN
cord-302047-vv5gpldi	172	19	,	,	,
cord-302047-vv5gpldi	172	20	as	as	IN
cord-302047-vv5gpldi	172	21	insertions	insertion	NNS
cord-302047-vv5gpldi	172	22	will	will	MD
cord-302047-vv5gpldi	172	23	often	often	RB
cord-302047-vv5gpldi	172	24	affect	affect	VB
cord-302047-vv5gpldi	172	25	multiple	multiple	JJ
cord-302047-vv5gpldi	172	26	genes	gene	NNS
cord-302047-vv5gpldi	172	27	.	.	.
cord-302047-vv5gpldi	173	1	We	-PRON-	PRP
cord-302047-vv5gpldi	173	2	focus	focus	VBP
cord-302047-vv5gpldi	173	3	exclusively	exclusively	RB
cord-302047-vv5gpldi	173	4	on	on	IN
cord-302047-vv5gpldi	173	5	engineered	engineer	VBN
cord-302047-vv5gpldi	173	6	viruses	virus	NNS
cord-302047-vv5gpldi	173	7	,	,	,
cord-302047-vv5gpldi	173	8	given	give	VBN
cord-302047-vv5gpldi	173	9	that	that	IN
cord-302047-vv5gpldi	173	10	there	there	EX
cord-302047-vv5gpldi	173	11	are	be	VBP
cord-302047-vv5gpldi	173	12	many	many	JJ
cord-302047-vv5gpldi	173	13	examples	example	NNS
cord-302047-vv5gpldi	173	14	for	for	IN
cord-302047-vv5gpldi	173	15	this	this	DT
cord-302047-vv5gpldi	173	16	virus	virus	NN
cord-302047-vv5gpldi	173	17	group	group	NN
cord-302047-vv5gpldi	173	18	.	.	.
cord-302047-vv5gpldi	174	1	Poliovirus	Poliovirus	NNP
cord-302047-vv5gpldi	174	2	is	be	VBZ
cord-302047-vv5gpldi	174	3	a	a	DT
cord-302047-vv5gpldi	174	4	good	good	JJ
cord-302047-vv5gpldi	174	5	candidate	candidate	NN
cord-302047-vv5gpldi	174	6	as	as	IN
cord-302047-vv5gpldi	174	7	a	a	DT
cord-302047-vv5gpldi	174	8	live	live	JJ
cord-302047-vv5gpldi	174	9	viral	viral	JJ
cord-302047-vv5gpldi	174	10	vector	vector	NN
cord-302047-vv5gpldi	174	11	for	for	IN
cord-302047-vv5gpldi	174	12	the	the	DT
cord-302047-vv5gpldi	174	13	expression	expression	NN
cord-302047-vv5gpldi	174	14	of	of	IN
cord-302047-vv5gpldi	174	15	foreign	foreign	JJ
cord-302047-vv5gpldi	174	16	genes	gene	NNS
cord-302047-vv5gpldi	174	17	,	,	,
cord-302047-vv5gpldi	174	18	since	since	IN
cord-302047-vv5gpldi	174	19	the	the	DT
cord-302047-vv5gpldi	174	20	attenuated	attenuated	JJ
cord-302047-vv5gpldi	174	21	Sabin	Sabin	NNP
cord-302047-vv5gpldi	174	22	strains	strain	NNS
cord-302047-vv5gpldi	174	23	of	of	IN
cord-302047-vv5gpldi	174	24	poliovirus	poliovirus	NN
cord-302047-vv5gpldi	174	25	elicit	elicit	VBP
cord-302047-vv5gpldi	174	26	strong	strong	JJ
cord-302047-vv5gpldi	174	27	protective	protective	JJ
cord-302047-vv5gpldi	174	28	immune	immune	JJ
cord-302047-vv5gpldi	174	29	responses	response	NNS
cord-302047-vv5gpldi	174	30	without	without	IN
cord-302047-vv5gpldi	174	31	causing	cause	VBG
cord-302047-vv5gpldi	174	32	disease	disease	NN
cord-302047-vv5gpldi	174	33	(	(	-LRB-
cord-302047-vv5gpldi	174	34	Sabin	Sabin	NNP
cord-302047-vv5gpldi	174	35	1957	1957	CD
cord-302047-vv5gpldi	174	36	)	)	-RRB-
cord-302047-vv5gpldi	174	37	.	.	.
cord-302047-vv5gpldi	175	1	Insertions	insertion	NNS
cord-302047-vv5gpldi	175	2	of	of	IN
cord-302047-vv5gpldi	175	3	up	up	IN
cord-302047-vv5gpldi	175	4	to	to	TO
cord-302047-vv5gpldi	175	5	534	534	CD
cord-302047-vv5gpldi	175	6	bp	bp	NNS
cord-302047-vv5gpldi	175	7	of	of	IN
cord-302047-vv5gpldi	175	8	the	the	DT
cord-302047-vv5gpldi	175	9	rotavirus	rotavirus	JJ
cord-302047-vv5gpldi	175	10	VP7	vp7	NN
cord-302047-vv5gpldi	175	11	gene	gene	NN
cord-302047-vv5gpldi	175	12	into	into	IN
cord-302047-vv5gpldi	175	13	Sabin	Sabin	NNP
cord-302047-vv5gpldi	175	14	3	3	CD
cord-302047-vv5gpldi	175	15	poliovirus	poliovirus	NN
cord-302047-vv5gpldi	175	16	gave	give	VBD
cord-302047-vv5gpldi	175	17	rise	rise	NN
cord-302047-vv5gpldi	175	18	to	to	IN
cord-302047-vv5gpldi	175	19	infectious	infectious	JJ
cord-302047-vv5gpldi	175	20	viruses	virus	NNS
cord-302047-vv5gpldi	175	21	that	that	WDT
cord-302047-vv5gpldi	175	22	expressed	express	VBD
cord-302047-vv5gpldi	175	23	portions	portion	NNS
cord-302047-vv5gpldi	175	24	of	of	IN
cord-302047-vv5gpldi	175	25	the	the	DT
cord-302047-vv5gpldi	175	26	VP7	VP7	NNP
cord-302047-vv5gpldi	175	27	outer	outer	JJ
cord-302047-vv5gpldi	175	28	capsid	capsid	NN
cord-302047-vv5gpldi	175	29	protein	protein	NN
cord-302047-vv5gpldi	175	30	(	(	-LRB-
cord-302047-vv5gpldi	175	31	Mattion	Mattion	NNP
cord-302047-vv5gpldi	175	32	et	et	NNP
cord-302047-vv5gpldi	175	33	al	al	NNP
cord-302047-vv5gpldi	175	34	.	.	.
cord-302047-vv5gpldi	175	35	1994	1994	CD
cord-302047-vv5gpldi	175	36	)	)	-RRB-
cord-302047-vv5gpldi	175	37	.	.	.
cord-302047-vv5gpldi	176	1	This	this	DT
cord-302047-vv5gpldi	176	2	is	be	VBZ
cord-302047-vv5gpldi	176	3	promising	promise	VBG
cord-302047-vv5gpldi	176	4	as	as	IN
cord-302047-vv5gpldi	176	5	antibodies	antibody	NNS
cord-302047-vv5gpldi	176	6	generated	generate	VBN
cord-302047-vv5gpldi	176	7	to	to	IN
cord-302047-vv5gpldi	176	8	VP7	vp7	NN
cord-302047-vv5gpldi	176	9	are	be	VBP
cord-302047-vv5gpldi	176	10	able	able	JJ
cord-302047-vv5gpldi	176	11	to	to	TO
cord-302047-vv5gpldi	176	12	neutralize	neutralize	VB
cord-302047-vv5gpldi	176	13	the	the	DT
cord-302047-vv5gpldi	176	14	virus	virus	NN
cord-302047-vv5gpldi	176	15	.	.	.
cord-302047-vv5gpldi	177	1	Nevertheless	nevertheless	RB
cord-302047-vv5gpldi	177	2	the	the	DT
cord-302047-vv5gpldi	177	3	size	size	NN
cord-302047-vv5gpldi	177	4	of	of	IN
cord-302047-vv5gpldi	177	5	the	the	DT
cord-302047-vv5gpldi	177	6	insert	insert	NN
cord-302047-vv5gpldi	177	7	in	in	IN
cord-302047-vv5gpldi	177	8	this	this	DT
cord-302047-vv5gpldi	177	9	construction	construction	NN
cord-302047-vv5gpldi	177	10	is	be	VBZ
cord-302047-vv5gpldi	177	11	limited	limit	VBN
cord-302047-vv5gpldi	177	12	as	as	IN
cord-302047-vv5gpldi	177	13	only	only	JJ
cord-302047-vv5gpldi	177	14	inserts	insert	NNS
cord-302047-vv5gpldi	177	15	of	of	IN
cord-302047-vv5gpldi	177	16	about	about	RB
cord-302047-vv5gpldi	177	17	300	300	CD
cord-302047-vv5gpldi	177	18	bp	bp	NNP
cord-302047-vv5gpldi	177	19	or	or	CC
cord-302047-vv5gpldi	177	20	smaller	small	JJR
cord-302047-vv5gpldi	177	21	were	be	VBD
cord-302047-vv5gpldi	177	22	stable	stable	JJ
cord-302047-vv5gpldi	177	23	upon	upon	IN
cord-302047-vv5gpldi	177	24	serial	serial	JJ
cord-302047-vv5gpldi	177	25	passages	passage	NNS
cord-302047-vv5gpldi	177	26	in	in	IN
cord-302047-vv5gpldi	177	27	tissue	tissue	NN
cord-302047-vv5gpldi	177	28	culture	culture	NN
cord-302047-vv5gpldi	177	29	,	,	,
cord-302047-vv5gpldi	177	30	whereas	whereas	IN
cord-302047-vv5gpldi	177	31	larger	large	JJR
cord-302047-vv5gpldi	177	32	insertions	insertion	NNS
cord-302047-vv5gpldi	177	33	failed	fail	VBD
cord-302047-vv5gpldi	177	34	to	to	TO
cord-302047-vv5gpldi	177	35	produce	produce	VB
cord-302047-vv5gpldi	177	36	infectious	infectious	JJ
cord-302047-vv5gpldi	177	37	viruses	virus	NNS
cord-302047-vv5gpldi	177	38	(	(	-LRB-
cord-302047-vv5gpldi	177	39	Mattion	Mattion	NNP
cord-302047-vv5gpldi	177	40	et	et	NNP
cord-302047-vv5gpldi	177	41	al	al	NNP
cord-302047-vv5gpldi	177	42	.	.	.
cord-302047-vv5gpldi	177	43	1994	1994	CD
cord-302047-vv5gpldi	177	44	)	)	-RRB-
cord-302047-vv5gpldi	177	45	.	.	.
cord-302047-vv5gpldi	178	1	One	one	CD
cord-302047-vv5gpldi	178	2	of	of	IN
cord-302047-vv5gpldi	178	3	the	the	DT
cord-302047-vv5gpldi	178	4	major	major	JJ
cord-302047-vv5gpldi	178	5	limitations	limitation	NNS
cord-302047-vv5gpldi	178	6	appears	appear	VBZ
cord-302047-vv5gpldi	178	7	to	to	TO
cord-302047-vv5gpldi	178	8	be	be	VB
cord-302047-vv5gpldi	178	9	the	the	DT
cord-302047-vv5gpldi	178	10	polyprotein	polyprotein	JJ
cord-302047-vv5gpldi	178	11	nature	nature	NN
cord-302047-vv5gpldi	178	12	of	of	IN
cord-302047-vv5gpldi	178	13	the	the	DT
cord-302047-vv5gpldi	178	14	genome	genome	NN
cord-302047-vv5gpldi	178	15	.	.	.
cord-302047-vv5gpldi	179	1	The	the	DT
cord-302047-vv5gpldi	179	2	recombinant	recombinant	JJ
cord-302047-vv5gpldi	179	3	viruses	virus	NNS
cord-302047-vv5gpldi	179	4	expressing	express	VBG
cord-302047-vv5gpldi	179	5	the	the	DT
cord-302047-vv5gpldi	179	6	inserted	insert	VBN
cord-302047-vv5gpldi	179	7	gene	gene	NN
cord-302047-vv5gpldi	179	8	were	be	VBD
cord-302047-vv5gpldi	179	9	found	find	VBN
cord-302047-vv5gpldi	179	10	to	to	TO
cord-302047-vv5gpldi	179	11	be	be	VB
cord-302047-vv5gpldi	179	12	slower	slow	JJR
cord-302047-vv5gpldi	179	13	in	in	IN
cord-302047-vv5gpldi	179	14	the	the	DT
cord-302047-vv5gpldi	179	15	assembly	assembly	NN
cord-302047-vv5gpldi	179	16	of	of	IN
cord-302047-vv5gpldi	179	17	infectious	infectious	JJ
cord-302047-vv5gpldi	179	18	virus	virus	NN
cord-302047-vv5gpldi	179	19	particles	particle	NNS
cord-302047-vv5gpldi	179	20	,	,	,
cord-302047-vv5gpldi	179	21	and	and	CC
cord-302047-vv5gpldi	179	22	showed	show	VBD
cord-302047-vv5gpldi	179	23	smaller	small	JJR
cord-302047-vv5gpldi	179	24	plaques	plaque	NNS
cord-302047-vv5gpldi	179	25	and	and	CC
cord-302047-vv5gpldi	179	26	lower	low	JJR
cord-302047-vv5gpldi	179	27	virus	virus	NN
cord-302047-vv5gpldi	179	28	titers	titer	NNS
cord-302047-vv5gpldi	179	29	.	.	.
cord-302047-vv5gpldi	180	1	This	this	DT
cord-302047-vv5gpldi	180	2	is	be	VBZ
cord-302047-vv5gpldi	180	3	possibly	possibly	RB
cord-302047-vv5gpldi	180	4	due	due	JJ
cord-302047-vv5gpldi	180	5	to	to	TO
cord-302047-vv5gpldi	180	6	slow	slow	JJ
cord-302047-vv5gpldi	180	7	cleavage	cleavage	NN
cord-302047-vv5gpldi	180	8	at	at	IN
cord-302047-vv5gpldi	180	9	the	the	DT
cord-302047-vv5gpldi	180	10	artificial	artificial	JJ
cord-302047-vv5gpldi	180	11	cleavage	cleavage	NN
cord-302047-vv5gpldi	180	12	sites	site	NNS
cord-302047-vv5gpldi	180	13	around	around	IN
cord-302047-vv5gpldi	180	14	the	the	DT
cord-302047-vv5gpldi	180	15	insert	insert	NN
cord-302047-vv5gpldi	180	16	(	(	-LRB-
cord-302047-vv5gpldi	180	17	Mattion	Mattion	NNP
cord-302047-vv5gpldi	180	18	et	et	NNP
cord-302047-vv5gpldi	180	19	al	al	NNP
cord-302047-vv5gpldi	180	20	.	.	.
cord-302047-vv5gpldi	180	21	1994	1994	CD
cord-302047-vv5gpldi	180	22	)	)	-RRB-
cord-302047-vv5gpldi	180	23	.	.	.
cord-302047-vv5gpldi	181	1	Sindbis	Sindbis	NNP
cord-302047-vv5gpldi	181	2	virus	virus	NN
cord-302047-vv5gpldi	181	3	,	,	,
cord-302047-vv5gpldi	181	4	another	another	DT
cord-302047-vv5gpldi	181	5	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	181	6	)	)	-RRB-
cord-302047-vv5gpldi	181	7	virus	virus	NN
cord-302047-vv5gpldi	181	8	genome	genome	NN
cord-302047-vv5gpldi	181	9	that	that	WDT
cord-302047-vv5gpldi	181	10	encodes	encode	VBZ
cord-302047-vv5gpldi	181	11	for	for	IN
cord-302047-vv5gpldi	181	12	a	a	DT
cord-302047-vv5gpldi	181	13	single	single	JJ
cord-302047-vv5gpldi	181	14	ORF	ORF	NNP
cord-302047-vv5gpldi	181	15	,	,	,
cord-302047-vv5gpldi	181	16	accepted	accept	VBD
cord-302047-vv5gpldi	181	17	relatively	relatively	RB
cord-302047-vv5gpldi	181	18	large	large	JJ
cord-302047-vv5gpldi	181	19	inserts	insert	NNS
cord-302047-vv5gpldi	181	20	of	of	IN
cord-302047-vv5gpldi	181	21	3.2	3.2	CD
cord-302047-vv5gpldi	181	22	kbp	kbp	NNS
cord-302047-vv5gpldi	181	23	in	in	IN
cord-302047-vv5gpldi	181	24	the	the	DT
cord-302047-vv5gpldi	181	25	11.8	11.8	CD
cord-302047-vv5gpldi	181	26	kbp	kbp	NNP
cord-302047-vv5gpldi	181	27	genome	genome	NNP
cord-302047-vv5gpldi	181	28	(	(	-LRB-
cord-302047-vv5gpldi	181	29	Pugachev	Pugachev	NNP
cord-302047-vv5gpldi	181	30	et	et	NNP
cord-302047-vv5gpldi	181	31	al	al	NNP
cord-302047-vv5gpldi	181	32	.	.	NNP
cord-302047-vv5gpldi	181	33	1995	1995	CD
cord-302047-vv5gpldi	181	34	)	)	-RRB-
cord-302047-vv5gpldi	181	35	.	.	.
cord-302047-vv5gpldi	182	1	However	however	RB
cord-302047-vv5gpldi	182	2	,	,	,
cord-302047-vv5gpldi	182	3	the	the	DT
cord-302047-vv5gpldi	182	4	recombinant	recombinant	JJ
cord-302047-vv5gpldi	182	5	Sindbis	Sindbis	NNP
cord-302047-vv5gpldi	182	6	viruses	virus	NNS
cord-302047-vv5gpldi	182	7	appeared	appear	VBD
cord-302047-vv5gpldi	182	8	unstable	unstable	JJ
cord-302047-vv5gpldi	182	9	and	and	CC
cord-302047-vv5gpldi	182	10	especially	especially	RB
cord-302047-vv5gpldi	182	11	inserts	insert	NNS
cord-302047-vv5gpldi	182	12	at	at	IN
cord-302047-vv5gpldi	182	13	the	the	DT
cord-302047-vv5gpldi	182	14	3	3	CD
cord-302047-vv5gpldi	182	15	0	0	CD
cord-302047-vv5gpldi	182	16	end	end	NN
cord-302047-vv5gpldi	182	17	were	be	VBD
cord-302047-vv5gpldi	182	18	rapidly	rapidly	RB
cord-302047-vv5gpldi	182	19	lost	lose	VBN
cord-302047-vv5gpldi	182	20	during	during	IN
cord-302047-vv5gpldi	182	21	serial	serial	JJ
cord-302047-vv5gpldi	182	22	passages	passage	NNS
cord-302047-vv5gpldi	182	23	,	,	,
cord-302047-vv5gpldi	182	24	suggesting	suggest	VBG
cord-302047-vv5gpldi	182	25	a	a	DT
cord-302047-vv5gpldi	182	26	positional	positional	JJ
cord-302047-vv5gpldi	182	27	effect	effect	NN
cord-302047-vv5gpldi	182	28	.	.	.
cord-302047-vv5gpldi	183	1	For	for	IN
cord-302047-vv5gpldi	183	2	members	member	NNS
cord-302047-vv5gpldi	183	3	of	of	IN
cord-302047-vv5gpldi	183	4	the	the	DT
cord-302047-vv5gpldi	183	5	Flaviviridae	Flaviviridae	NNP
cord-302047-vv5gpldi	183	6	family	family	NN
cord-302047-vv5gpldi	183	7	,	,	,
cord-302047-vv5gpldi	183	8	such	such	JJ
cord-302047-vv5gpldi	183	9	as	as	IN
cord-302047-vv5gpldi	183	10	West	West	NNP
cord-302047-vv5gpldi	183	11	Nile	Nile	NNP
cord-302047-vv5gpldi	183	12	virus	virus	NN
cord-302047-vv5gpldi	183	13	and	and	CC
cord-302047-vv5gpldi	183	14	hepatitis	hepatitis	NN
cord-302047-vv5gpldi	183	15	C	C	NNP
cord-302047-vv5gpldi	183	16	virus	virus	NN
cord-302047-vv5gpldi	183	17	(	(	-LRB-
cord-302047-vv5gpldi	183	18	HCV	HCV	NNP
cord-302047-vv5gpldi	183	19	)	)	-RRB-
cord-302047-vv5gpldi	183	20	,	,	,
cord-302047-vv5gpldi	183	21	inserted	insert	VBD
cord-302047-vv5gpldi	183	22	reporter	reporter	NN
cord-302047-vv5gpldi	183	23	genes	gene	NNS
cord-302047-vv5gpldi	183	24	appear	appear	VBP
cord-302047-vv5gpldi	183	25	to	to	TO
cord-302047-vv5gpldi	183	26	be	be	VB
cord-302047-vv5gpldi	183	27	unstable	unstable	JJ
cord-302047-vv5gpldi	183	28	.	.	.
cord-302047-vv5gpldi	184	1	This	this	DT
cord-302047-vv5gpldi	184	2	instability	instability	NN
cord-302047-vv5gpldi	184	3	is	be	VBZ
cord-302047-vv5gpldi	184	4	related	relate	VBN
cord-302047-vv5gpldi	184	5	to	to	IN
cord-302047-vv5gpldi	184	6	the	the	DT
cord-302047-vv5gpldi	184	7	size	size	NN
cord-302047-vv5gpldi	184	8	of	of	IN
cord-302047-vv5gpldi	184	9	the	the	DT
cord-302047-vv5gpldi	184	10	insert	insert	NN
cord-302047-vv5gpldi	184	11	,	,	,
cord-302047-vv5gpldi	184	12	and	and	CC
cord-302047-vv5gpldi	184	13	comes	come	VBZ
cord-302047-vv5gpldi	184	14	about	about	RP
cord-302047-vv5gpldi	184	15	because	because	IN
cord-302047-vv5gpldi	184	16	of	of	IN
cord-302047-vv5gpldi	184	17	the	the	DT
cord-302047-vv5gpldi	184	18	disruption	disruption	NN
cord-302047-vv5gpldi	184	19	of	of	IN
cord-302047-vv5gpldi	184	20	structural	structural	JJ
cord-302047-vv5gpldi	184	21	RNA	RNA	NNP
cord-302047-vv5gpldi	184	22	elements	element	NNS
cord-302047-vv5gpldi	184	23	required	require	VBN
cord-302047-vv5gpldi	184	24	for	for	IN
cord-302047-vv5gpldi	184	25	viral	viral	JJ
cord-302047-vv5gpldi	184	26	replication	replication	NN
cord-302047-vv5gpldi	184	27	(	(	-LRB-
cord-302047-vv5gpldi	184	28	Ruggli	Ruggli	NNP
cord-302047-vv5gpldi	184	29	and	and	CC
cord-302047-vv5gpldi	184	30	Rice	Rice	NNP
cord-302047-vv5gpldi	184	31	1999	1999	CD
cord-302047-vv5gpldi	184	32	;	;	:
cord-302047-vv5gpldi	184	33	Pierson	Pierson	NNP
cord-302047-vv5gpldi	184	34	et	et	NNP
cord-302047-vv5gpldi	184	35	al	al	NNP
cord-302047-vv5gpldi	184	36	.	.	NNP
cord-302047-vv5gpldi	184	37	2005	2005	CD
cord-302047-vv5gpldi	184	38	)	)	-RRB-
cord-302047-vv5gpldi	184	39	.	.	.
cord-302047-vv5gpldi	185	1	To	to	TO
cord-302047-vv5gpldi	185	2	cope	cope	VB
cord-302047-vv5gpldi	185	3	with	with	IN
cord-302047-vv5gpldi	185	4	these	these	DT
cord-302047-vv5gpldi	185	5	issues	issue	NNS
cord-302047-vv5gpldi	185	6	,	,	,
cord-302047-vv5gpldi	185	7	recombinant	recombinant	JJ
cord-302047-vv5gpldi	185	8	Flaviviridae	Flaviviridae	NNP
cord-302047-vv5gpldi	185	9	viruses	virus	NNS
cord-302047-vv5gpldi	185	10	carrying	carry	VBG
cord-302047-vv5gpldi	185	11	the	the	DT
cord-302047-vv5gpldi	185	12	split	split	NN
cord-302047-vv5gpldi	185	13	-	-	HYPH
cord-302047-vv5gpldi	185	14	luciferase	luciferase	NN
cord-302047-vv5gpldi	185	15	gene	gene	NN
cord-302047-vv5gpldi	185	16	were	be	VBD
cord-302047-vv5gpldi	185	17	generated	generate	VBN
cord-302047-vv5gpldi	185	18	(	(	-LRB-
cord-302047-vv5gpldi	185	19	Tamura	Tamura	NNP
cord-302047-vv5gpldi	185	20	et	et	NNP
cord-302047-vv5gpldi	185	21	al	al	NNP
cord-302047-vv5gpldi	185	22	.	.	.
cord-302047-vv5gpldi	185	23	2018	2018	CD
cord-302047-vv5gpldi	185	24	)	)	-RRB-
cord-302047-vv5gpldi	185	25	,	,	,
cord-302047-vv5gpldi	185	26	including	include	VBG
cord-302047-vv5gpldi	185	27	dengue	dengue	NN
cord-302047-vv5gpldi	185	28	virus	virus	NN
cord-302047-vv5gpldi	185	29	,	,	,
cord-302047-vv5gpldi	185	30	Japanese	japanese	JJ
cord-302047-vv5gpldi	185	31	encephalitis	encephalitis	RB
cord-302047-vv5gpldi	185	32	virus	virus	NN
cord-302047-vv5gpldi	185	33	,	,	,
cord-302047-vv5gpldi	185	34	HCV	HCV	NNP
cord-302047-vv5gpldi	185	35	and	and	CC
cord-302047-vv5gpldi	185	36	bovine	bovine	JJ
cord-302047-vv5gpldi	185	37	viral	viral	JJ
cord-302047-vv5gpldi	185	38	diarrhea	diarrhea	NN
cord-302047-vv5gpldi	185	39	virus	virus	NN
cord-302047-vv5gpldi	185	40	.	.	.
cord-302047-vv5gpldi	186	1	In	in	IN
cord-302047-vv5gpldi	186	2	vitro	vitro	FW
cord-302047-vv5gpldi	186	3	,	,	,
cord-302047-vv5gpldi	186	4	these	these	DT
cord-302047-vv5gpldi	186	5	recombinant	recombinant	JJ
cord-302047-vv5gpldi	186	6	viruses	virus	NNS
cord-302047-vv5gpldi	186	7	appear	appear	VBP
cord-302047-vv5gpldi	186	8	to	to	TO
cord-302047-vv5gpldi	186	9	be	be	VB
cord-302047-vv5gpldi	186	10	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	186	11	stable	stable	JJ
cord-302047-vv5gpldi	186	12	and	and	CC
cord-302047-vv5gpldi	186	13	propagation	propagation	NN
cord-302047-vv5gpldi	186	14	was	be	VBD
cord-302047-vv5gpldi	186	15	comparable	comparable	JJ
cord-302047-vv5gpldi	186	16	to	to	IN
cord-302047-vv5gpldi	186	17	the	the	DT
cord-302047-vv5gpldi	186	18	wild	wild	JJ
cord-302047-vv5gpldi	186	19	-	-	HYPH
cord-302047-vv5gpldi	186	20	type	type	NN
cord-302047-vv5gpldi	186	21	virus	virus	NN
cord-302047-vv5gpldi	186	22	,	,	,
cord-302047-vv5gpldi	186	23	most	most	RBS
cord-302047-vv5gpldi	186	24	probably	probably	RB
cord-302047-vv5gpldi	186	25	due	due	JJ
cord-302047-vv5gpldi	186	26	to	to	IN
cord-302047-vv5gpldi	186	27	the	the	DT
cord-302047-vv5gpldi	186	28	small	small	JJ
cord-302047-vv5gpldi	186	29	11	11	CD
cord-302047-vv5gpldi	186	30	amino	amino	NN
cord-302047-vv5gpldi	186	31	acid	acid	NN
cord-302047-vv5gpldi	186	32	insert	insert	NN
cord-302047-vv5gpldi	186	33	size	size	NN
cord-302047-vv5gpldi	186	34	.	.	.
cord-302047-vv5gpldi	187	1	To	to	TO
cord-302047-vv5gpldi	187	2	demonstrate	demonstrate	VB
cord-302047-vv5gpldi	187	3	the	the	DT
cord-302047-vv5gpldi	187	4	utility	utility	NN
cord-302047-vv5gpldi	187	5	of	of	IN
cord-302047-vv5gpldi	187	6	the	the	DT
cord-302047-vv5gpldi	187	7	split	split	JJ
cord-302047-vv5gpldi	187	8	reporter	reporter	NN
cord-302047-vv5gpldi	187	9	system	system	NN
cord-302047-vv5gpldi	187	10	-	-	:
cord-302047-vv5gpldi	187	11	to	to	TO
cord-302047-vv5gpldi	187	12	determine	determine	VB
cord-302047-vv5gpldi	187	13	in	in	IN
cord-302047-vv5gpldi	187	14	vivo	vivo	FW
cord-302047-vv5gpldi	187	15	viral	viral	JJ
cord-302047-vv5gpldi	187	16	dynamics	dynamic	NNS
cord-302047-vv5gpldi	187	17	and	and	CC
cord-302047-vv5gpldi	187	18	the	the	DT
cord-302047-vv5gpldi	187	19	efficacy	efficacy	NN
cord-302047-vv5gpldi	187	20	of	of	IN
cord-302047-vv5gpldi	187	21	antiviral	antiviral	JJ
cord-302047-vv5gpldi	187	22	reagents	reagent	NNS
cord-302047-vv5gpldi	187	23	-	-	:
cord-302047-vv5gpldi	187	24	the	the	DT
cord-302047-vv5gpldi	187	25	recombinant	recombinant	JJ
cord-302047-vv5gpldi	187	26	HCV	HCV	NNP
cord-302047-vv5gpldi	187	27	was	be	VBD
cord-302047-vv5gpldi	187	28	tested	test	VBN
cord-302047-vv5gpldi	187	29	in	in	IN
cord-302047-vv5gpldi	187	30	chimeric	chimeric	JJ
cord-302047-vv5gpldi	187	31	mice	mouse	NNS
cord-302047-vv5gpldi	187	32	.	.	.
cord-302047-vv5gpldi	188	1	Chronic	chronic	JJ
cord-302047-vv5gpldi	188	2	infection	infection	NN
cord-302047-vv5gpldi	188	3	was	be	VBD
cord-302047-vv5gpldi	188	4	established	establish	VBN
cord-302047-vv5gpldi	188	5	and	and	CC
cord-302047-vv5gpldi	188	6	the	the	DT
cord-302047-vv5gpldi	188	7	luciferase	luciferase	NN
cord-302047-vv5gpldi	188	8	gene	gene	NN
cord-302047-vv5gpldi	188	9	was	be	VBD
cord-302047-vv5gpldi	188	10	stably	stably	RB
cord-302047-vv5gpldi	188	11	maintained	maintain	VBN
cord-302047-vv5gpldi	188	12	in	in	IN
cord-302047-vv5gpldi	188	13	the	the	DT
cord-302047-vv5gpldi	188	14	viral	viral	JJ
cord-302047-vv5gpldi	188	15	genome	genome	NN
cord-302047-vv5gpldi	188	16	(	(	-LRB-
cord-302047-vv5gpldi	188	17	Tamura	Tamura	NNP
cord-302047-vv5gpldi	188	18	et	et	NNP
cord-302047-vv5gpldi	188	19	al	al	NNP
cord-302047-vv5gpldi	188	20	.	.	.
cord-302047-vv5gpldi	188	21	2018	2018	CD
cord-302047-vv5gpldi	188	22	)	)	-RRB-
cord-302047-vv5gpldi	188	23	.	.	.
cord-302047-vv5gpldi	189	1	Live	live	JJ
cord-302047-vv5gpldi	189	2	attenuated	attenuated	JJ
cord-302047-vv5gpldi	189	3	vaccines	vaccine	NNS
cord-302047-vv5gpldi	189	4	for	for	IN
cord-302047-vv5gpldi	189	5	porcine	porcine	JJ
cord-302047-vv5gpldi	189	6	reproductive	reproductive	JJ
cord-302047-vv5gpldi	189	7	and	and	CC
cord-302047-vv5gpldi	189	8	respiratory	respiratory	JJ
cord-302047-vv5gpldi	189	9	syndrome	syndrome	NN
cord-302047-vv5gpldi	189	10	(	(	-LRB-
cord-302047-vv5gpldi	189	11	PRRSV	PRRSV	NNP
cord-302047-vv5gpldi	189	12	)	)	-RRB-
cord-302047-vv5gpldi	189	13	have	have	VBP
cord-302047-vv5gpldi	189	14	failed	fail	VBN
cord-302047-vv5gpldi	189	15	to	to	TO
cord-302047-vv5gpldi	189	16	provide	provide	VB
cord-302047-vv5gpldi	189	17	effective	effective	JJ
cord-302047-vv5gpldi	189	18	protection	protection	NN
cord-302047-vv5gpldi	189	19	due	due	IN
cord-302047-vv5gpldi	189	20	to	to	IN
cord-302047-vv5gpldi	189	21	the	the	DT
cord-302047-vv5gpldi	189	22	genetic	genetic	JJ
cord-302047-vv5gpldi	189	23	diversity	diversity	NN
cord-302047-vv5gpldi	189	24	of	of	IN
cord-302047-vv5gpldi	189	25	circulating	circulate	VBG
cord-302047-vv5gpldi	189	26	PRRSV	PRRSV	NNP
cord-302047-vv5gpldi	189	27	strains	strain	NNS
cord-302047-vv5gpldi	189	28	.	.	.
cord-302047-vv5gpldi	190	1	To	to	TO
cord-302047-vv5gpldi	190	2	improve	improve	VB
cord-302047-vv5gpldi	190	3	the	the	DT
cord-302047-vv5gpldi	190	4	efficacy	efficacy	NN
cord-302047-vv5gpldi	190	5	of	of	IN
cord-302047-vv5gpldi	190	6	PRRSV	PRRSV	NNP
cord-302047-vv5gpldi	190	7	vaccination	vaccination	NN
cord-302047-vv5gpldi	190	8	,	,	,
cord-302047-vv5gpldi	190	9	a	a	DT
cord-302047-vv5gpldi	190	10	recombinant	recombinant	JJ
cord-302047-vv5gpldi	190	11	virus	virus	NN
cord-302047-vv5gpldi	190	12	expressing	express	VBG
cord-302047-vv5gpldi	190	13	porcine	porcine	JJ
cord-302047-vv5gpldi	190	14	Interleukin-4	Interleukin-4	NNP
cord-302047-vv5gpldi	190	15	(	(	-LRB-
cord-302047-vv5gpldi	190	16	a	a	DT
cord-302047-vv5gpldi	190	17	regulator	regulator	NN
cord-302047-vv5gpldi	190	18	of	of	IN
cord-302047-vv5gpldi	190	19	the	the	DT
cord-302047-vv5gpldi	190	20	immune	immune	JJ
cord-302047-vv5gpldi	190	21	response	response	NN
cord-302047-vv5gpldi	190	22	)	)	-RRB-
cord-302047-vv5gpldi	190	23	was	be	VBD
cord-302047-vv5gpldi	190	24	constructed	construct	VBN
cord-302047-vv5gpldi	190	25	(	(	-LRB-
cord-302047-vv5gpldi	190	26	Zhijun	Zhijun	NNP
cord-302047-vv5gpldi	190	27	.	.	.
cord-302047-vv5gpldi	191	1	This	this	DT
cord-302047-vv5gpldi	191	2	recombinant	recombinant	JJ
cord-302047-vv5gpldi	191	3	virus	virus	NN
cord-302047-vv5gpldi	191	4	remained	remain	VBD
cord-302047-vv5gpldi	191	5	stable	stable	JJ
cord-302047-vv5gpldi	191	6	upon	upon	IN
cord-302047-vv5gpldi	191	7	serial	serial	JJ
cord-302047-vv5gpldi	191	8	passaging	passaging	NN
cord-302047-vv5gpldi	191	9	in	in	IN
cord-302047-vv5gpldi	191	10	vitro	vitro	FW
cord-302047-vv5gpldi	191	11	,	,	,
cord-302047-vv5gpldi	191	12	and	and	CC
cord-302047-vv5gpldi	191	13	induced	induce	VBN
cord-302047-vv5gpldi	191	14	higher	high	JJR
cord-302047-vv5gpldi	191	15	ratios	ratio	NNS
cord-302047-vv5gpldi	191	16	of	of	IN
cord-302047-vv5gpldi	191	17	Interleukin-4	Interleukin-4	NNP
cord-302047-vv5gpldi	191	18	and	and	CC
cord-302047-vv5gpldi	191	19	CD4þCD8þ	CD4þCD8þ	NNP
cord-302047-vv5gpldi	191	20	doublepositive	doublepositive	NNP
cord-302047-vv5gpldi	191	21	T	T	NNP
cord-302047-vv5gpldi	191	22	cells	cell	NNS
cord-302047-vv5gpldi	191	23	in	in	IN
cord-302047-vv5gpldi	191	24	vivo	vivo	NN
cord-302047-vv5gpldi	191	25	.	.	.
cord-302047-vv5gpldi	192	1	Despite	despite	IN
cord-302047-vv5gpldi	192	2	the	the	DT
cord-302047-vv5gpldi	192	3	presumably	presumably	RB
cord-302047-vv5gpldi	192	4	better	well	JJR
cord-302047-vv5gpldi	192	5	immune	immune	JJ
cord-302047-vv5gpldi	192	6	response	response	NN
cord-302047-vv5gpldi	192	7	of	of	IN
cord-302047-vv5gpldi	192	8	the	the	DT
cord-302047-vv5gpldi	192	9	host	host	NN
cord-302047-vv5gpldi	192	10	,	,	,
cord-302047-vv5gpldi	192	11	the	the	DT
cord-302047-vv5gpldi	192	12	recombinant	recombinant	JJ
cord-302047-vv5gpldi	192	13	PRRSV	PRRSV	NNP
cord-302047-vv5gpldi	192	14	vaccine	vaccine	NN
cord-302047-vv5gpldi	192	15	did	do	VBD
cord-302047-vv5gpldi	192	16	not	not	RB
cord-302047-vv5gpldi	192	17	significantly	significantly	RB
cord-302047-vv5gpldi	192	18	improve	improve	VB
cord-302047-vv5gpldi	192	19	protection	protection	NN
cord-302047-vv5gpldi	192	20	efficacy	efficacy	NN
cord-302047-vv5gpldi	192	21	(	(	-LRB-
cord-302047-vv5gpldi	192	22	Zhijun	Zhijun	NNP
cord-302047-vv5gpldi	192	23	.	.	.
cord-302047-vv5gpldi	193	1	In	in	IN
cord-302047-vv5gpldi	193	2	another	another	DT
cord-302047-vv5gpldi	193	3	attempt	attempt	NN
cord-302047-vv5gpldi	193	4	,	,	,
cord-302047-vv5gpldi	193	5	granulocyte	granulocyte	NN
cord-302047-vv5gpldi	193	6	-	-	HYPH
cord-302047-vv5gpldi	193	7	macrophage	macrophage	NN
cord-302047-vv5gpldi	193	8	colony	colony	NN
cord-302047-vv5gpldi	193	9	-	-	HYPH
cord-302047-vv5gpldi	193	10	stimulating	stimulate	VBG
cord-302047-vv5gpldi	193	11	factor	factor	NN
cord-302047-vv5gpldi	193	12	(	(	-LRB-
cord-302047-vv5gpldi	193	13	GM	GM	NNP
cord-302047-vv5gpldi	193	14	-	-	HYPH
cord-302047-vv5gpldi	193	15	CSF	CSF	NNP
cord-302047-vv5gpldi	193	16	)	)	-RRB-
cord-302047-vv5gpldi	193	17	was	be	VBD
cord-302047-vv5gpldi	193	18	inserted	insert	VBN
cord-302047-vv5gpldi	193	19	in	in	IN
cord-302047-vv5gpldi	193	20	a	a	DT
cord-302047-vv5gpldi	193	21	PRRSV	PRRSV	NNP
cord-302047-vv5gpldi	193	22	vaccine	vaccine	NN
cord-302047-vv5gpldi	193	23	strain	strain	NN
cord-302047-vv5gpldi	193	24	.	.	.
cord-302047-vv5gpldi	194	1	The	the	DT
cord-302047-vv5gpldi	194	2	inserted	insert	VBN
cord-302047-vv5gpldi	194	3	gene	gene	NN
cord-302047-vv5gpldi	194	4	was	be	VBD
cord-302047-vv5gpldi	194	5	stably	stably	RB
cord-302047-vv5gpldi	194	6	expressed	express	VBN
cord-302047-vv5gpldi	194	7	upon	upon	IN
cord-302047-vv5gpldi	194	8	serial	serial	JJ
cord-302047-vv5gpldi	194	9	passaging	passaging	NN
cord-302047-vv5gpldi	194	10	in	in	IN
cord-302047-vv5gpldi	194	11	vitro	vitro	FW
cord-302047-vv5gpldi	194	12	,	,	,
cord-302047-vv5gpldi	194	13	and	and	CC
cord-302047-vv5gpldi	194	14	the	the	DT
cord-302047-vv5gpldi	194	15	presence	presence	NN
cord-302047-vv5gpldi	194	16	of	of	IN
cord-302047-vv5gpldi	194	17	GM	GM	NNP
cord-302047-vv5gpldi	194	18	-	-	HYPH
cord-302047-vv5gpldi	194	19	CSF	CSF	NNP
cord-302047-vv5gpldi	194	20	led	lead	VBD
cord-302047-vv5gpldi	194	21	to	to	IN
cord-302047-vv5gpldi	194	22	increased	increase	VBN
cord-302047-vv5gpldi	194	23	surface	surface	NN
cord-302047-vv5gpldi	194	24	expression	expression	NN
cord-302047-vv5gpldi	194	25	of	of	IN
cord-302047-vv5gpldi	194	26	MHCIþ	MHCIþ	NNS
cord-302047-vv5gpldi	194	27	,	,	,
cord-302047-vv5gpldi	194	28	MHCIIþ	MHCIIþ	NNP
cord-302047-vv5gpldi	194	29	,	,	,
cord-302047-vv5gpldi	194	30	and	and	CC
cord-302047-vv5gpldi	194	31	CD80/86þ	CD80/86þ	NNP
cord-302047-vv5gpldi	194	32	(	(	-LRB-
cord-302047-vv5gpldi	194	33	Yu	Yu	NNP
cord-302047-vv5gpldi	194	34	et	et	FW
cord-302047-vv5gpldi	194	35	al	al	NNP
cord-302047-vv5gpldi	194	36	.	.	NNP
cord-302047-vv5gpldi	194	37	2014	2014	CD
cord-302047-vv5gpldi	194	38	)	)	-RRB-
cord-302047-vv5gpldi	194	39	.	.	.
cord-302047-vv5gpldi	195	1	Although	although	IN
cord-302047-vv5gpldi	195	2	evaluated	evaluate	VBN
cord-302047-vv5gpldi	195	3	solely	solely	RB
cord-302047-vv5gpldi	195	4	in	in	IN
cord-302047-vv5gpldi	195	5	vitro	vitro	FW
cord-302047-vv5gpldi	195	6	,	,	,
cord-302047-vv5gpldi	195	7	this	this	DT
cord-302047-vv5gpldi	195	8	recombinant	recombinant	JJ
cord-302047-vv5gpldi	195	9	strain	strain	NN
cord-302047-vv5gpldi	195	10	is	be	VBZ
cord-302047-vv5gpldi	195	11	expected	expect	VBN
cord-302047-vv5gpldi	195	12	to	to	TO
cord-302047-vv5gpldi	195	13	elicit	elicit	VB
cord-302047-vv5gpldi	195	14	stronger	strong	JJR
cord-302047-vv5gpldi	195	15	immune	immune	JJ
cord-302047-vv5gpldi	195	16	responses	response	NNS
cord-302047-vv5gpldi	195	17	and	and	CC
cord-302047-vv5gpldi	195	18	hereby	hereby	RB
cord-302047-vv5gpldi	195	19	improve	improve	VB
cord-302047-vv5gpldi	195	20	vaccine	vaccine	NN
cord-302047-vv5gpldi	195	21	efficacy	efficacy	NN
cord-302047-vv5gpldi	195	22	against	against	IN
cord-302047-vv5gpldi	195	23	PRRSV	PRRSV	NNP
cord-302047-vv5gpldi	195	24	infection	infection	NN
cord-302047-vv5gpldi	195	25	.	.	.
cord-302047-vv5gpldi	196	1	It	-PRON-	PRP
cord-302047-vv5gpldi	196	2	has	have	VBZ
cord-302047-vv5gpldi	196	3	been	be	VBN
cord-302047-vv5gpldi	196	4	shown	show	VBN
cord-302047-vv5gpldi	196	5	that	that	IN
cord-302047-vv5gpldi	196	6	many	many	JJ
cord-302047-vv5gpldi	196	7	different	different	JJ
cord-302047-vv5gpldi	196	8	plant	plant	NN
cord-302047-vv5gpldi	196	9	viruses	virus	NNS
cord-302047-vv5gpldi	196	10	can	can	MD
cord-302047-vv5gpldi	196	11	express	express	VB
cord-302047-vv5gpldi	196	12	foreign	foreign	JJ
cord-302047-vv5gpldi	196	13	genes	gene	NNS
cord-302047-vv5gpldi	196	14	,	,	,
cord-302047-vv5gpldi	196	15	and	and	CC
cord-302047-vv5gpldi	196	16	they	-PRON-	PRP
cord-302047-vv5gpldi	196	17	have	have	VBP
cord-302047-vv5gpldi	196	18	the	the	DT
cord-302047-vv5gpldi	196	19	advantage	advantage	NN
cord-302047-vv5gpldi	196	20	being	be	VBG
cord-302047-vv5gpldi	196	21	able	able	JJ
cord-302047-vv5gpldi	196	22	to	to	TO
cord-302047-vv5gpldi	196	23	express	express	VB
cord-302047-vv5gpldi	196	24	these	these	DT
cord-302047-vv5gpldi	196	25	directly	directly	RB
cord-302047-vv5gpldi	196	26	in	in	IN
cord-302047-vv5gpldi	196	27	vivo	vivo	NN
cord-302047-vv5gpldi	196	28	.	.	.
cord-302047-vv5gpldi	197	1	As	as	IN
cord-302047-vv5gpldi	197	2	an	an	DT
cord-302047-vv5gpldi	197	3	initial	initial	JJ
cord-302047-vv5gpldi	197	4	strategy	strategy	NN
cord-302047-vv5gpldi	197	5	to	to	TO
cord-302047-vv5gpldi	197	6	express	express	VB
cord-302047-vv5gpldi	197	7	foreign	foreign	JJ
cord-302047-vv5gpldi	197	8	genes	gene	NNS
cord-302047-vv5gpldi	197	9	in	in	IN
cord-302047-vv5gpldi	197	10	plants	plant	NNS
cord-302047-vv5gpldi	197	11	,	,	,
cord-302047-vv5gpldi	197	12	on	on	IN
cord-302047-vv5gpldi	197	13	many	many	JJ
cord-302047-vv5gpldi	197	14	occasions	occasion	NNS
cord-302047-vv5gpldi	197	15	viral	viral	JJ
cord-302047-vv5gpldi	197	16	genes	gene	NNS
cord-302047-vv5gpldi	197	17	were	be	VBD
cord-302047-vv5gpldi	197	18	replaced	replace	VBN
cord-302047-vv5gpldi	197	19	with	with	IN
cord-302047-vv5gpldi	197	20	the	the	DT
cord-302047-vv5gpldi	197	21	gene	gene	NN
cord-302047-vv5gpldi	197	22	of	of	IN
cord-302047-vv5gpldi	197	23	interest	interest	NN
cord-302047-vv5gpldi	197	24	(	(	-LRB-
cord-302047-vv5gpldi	197	25	gene	gene	NN
cord-302047-vv5gpldi	197	26	replacement	replacement	NN
cord-302047-vv5gpldi	197	27	instead	instead	RB
cord-302047-vv5gpldi	197	28	of	of	IN
cord-302047-vv5gpldi	197	29	gene	gene	NN
cord-302047-vv5gpldi	197	30	insertion	insertion	NN
cord-302047-vv5gpldi	197	31	)	)	-RRB-
cord-302047-vv5gpldi	197	32	.	.	.
cord-302047-vv5gpldi	198	1	This	this	DT
cord-302047-vv5gpldi	198	2	strategy	strategy	NN
cord-302047-vv5gpldi	198	3	appeared	appear	VBD
cord-302047-vv5gpldi	198	4	to	to	TO
cord-302047-vv5gpldi	198	5	be	be	VB
cord-302047-vv5gpldi	198	6	(	(	-LRB-
cord-302047-vv5gpldi	198	7	partially	partially	RB
cord-302047-vv5gpldi	198	8	)	)	-RRB-
cord-302047-vv5gpldi	198	9	successful	successful	JJ
cord-302047-vv5gpldi	198	10	in	in	IN
cord-302047-vv5gpldi	198	11	plant	plant	NN
cord-302047-vv5gpldi	198	12	ssDNA	ssdna	NN
cord-302047-vv5gpldi	198	13	viruses	virus	NNS
cord-302047-vv5gpldi	198	14	(	(	-LRB-
cord-302047-vv5gpldi	198	15	Hayes	Hayes	NNP
cord-302047-vv5gpldi	198	16	et	et	NNP
cord-302047-vv5gpldi	198	17	al	al	NNP
cord-302047-vv5gpldi	198	18	.	.	.
cord-302047-vv5gpldi	198	19	1988	1988	CD
cord-302047-vv5gpldi	198	20	;	;	:
cord-302047-vv5gpldi	198	21	Ward	Ward	NNP
cord-302047-vv5gpldi	198	22	,	,	,
cord-302047-vv5gpldi	198	23	Etessami	Etessami	NNP
cord-302047-vv5gpldi	198	24	,	,	,
cord-302047-vv5gpldi	198	25	and	and	CC
cord-302047-vv5gpldi	198	26	Stanley	Stanley	NNP
cord-302047-vv5gpldi	198	27	1988	1988	CD
cord-302047-vv5gpldi	198	28	;	;	:
cord-302047-vv5gpldi	198	29	Hayes	Hayes	NNP
cord-302047-vv5gpldi	198	30	,	,	,
cord-302047-vv5gpldi	198	31	Coutts	Coutts	NNP
cord-302047-vv5gpldi	198	32	,	,	,
cord-302047-vv5gpldi	198	33	and	and	CC
cord-302047-vv5gpldi	198	34	Buck	Buck	NNP
cord-302047-vv5gpldi	198	35	1989	1989	CD
cord-302047-vv5gpldi	198	36	)	)	-RRB-
cord-302047-vv5gpldi	198	37	,	,	,
cord-302047-vv5gpldi	198	38	as	as	IN
cord-302047-vv5gpldi	198	39	the	the	DT
cord-302047-vv5gpldi	198	40	replaced	replace	VBN
cord-302047-vv5gpldi	198	41	coat	coat	NN
cord-302047-vv5gpldi	198	42	protein	protein	NN
cord-302047-vv5gpldi	198	43	did	do	VBD
cord-302047-vv5gpldi	198	44	not	not	RB
cord-302047-vv5gpldi	198	45	appear	appear	VB
cord-302047-vv5gpldi	198	46	to	to	TO
cord-302047-vv5gpldi	198	47	play	play	VB
cord-302047-vv5gpldi	198	48	an	an	DT
cord-302047-vv5gpldi	198	49	essential	essential	JJ
cord-302047-vv5gpldi	198	50	role	role	NN
cord-302047-vv5gpldi	198	51	in	in	IN
cord-302047-vv5gpldi	198	52	virus	virus	NN
cord-302047-vv5gpldi	198	53	spread	spread	VBN
cord-302047-vv5gpldi	198	54	throughout	throughout	IN
cord-302047-vv5gpldi	198	55	the	the	DT
cord-302047-vv5gpldi	198	56	plant	plant	NN
cord-302047-vv5gpldi	198	57	host	host	NN
cord-302047-vv5gpldi	198	58	(	(	-LRB-
cord-302047-vv5gpldi	198	59	Ward	Ward	NNP
cord-302047-vv5gpldi	198	60	,	,	,
cord-302047-vv5gpldi	198	61	Etessami	Etessami	NNP
cord-302047-vv5gpldi	198	62	,	,	,
cord-302047-vv5gpldi	198	63	and	and	CC
cord-302047-vv5gpldi	198	64	Stanley	Stanley	NNP
cord-302047-vv5gpldi	198	65	1988	1988	CD
cord-302047-vv5gpldi	198	66	)	)	-RRB-
cord-302047-vv5gpldi	198	67	.	.	.
cord-302047-vv5gpldi	199	1	However	however	RB
cord-302047-vv5gpldi	199	2	,	,	,
cord-302047-vv5gpldi	199	3	viral	viral	JJ
cord-302047-vv5gpldi	199	4	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	199	5	)	)	-RRB-
cord-302047-vv5gpldi	199	6	genomes	genome	NNS
cord-302047-vv5gpldi	199	7	seem	seem	VBP
cord-302047-vv5gpldi	199	8	to	to	TO
cord-302047-vv5gpldi	199	9	be	be	VB
cord-302047-vv5gpldi	199	10	less	less	JJR
cord-302047-vv5gpldi	199	11	plastic	plastic	NN
cord-302047-vv5gpldi	199	12	as	as	IN
cord-302047-vv5gpldi	199	13	the	the	DT
cord-302047-vv5gpldi	199	14	replacement	replacement	NN
cord-302047-vv5gpldi	199	15	strategy	strategy	NN
cord-302047-vv5gpldi	199	16	was	be	VBD
cord-302047-vv5gpldi	199	17	mostly	mostly	RB
cord-302047-vv5gpldi	199	18	unsuccessful	unsuccessful	JJ
cord-302047-vv5gpldi	199	19	in	in	IN
cord-302047-vv5gpldi	199	20	plant	plant	NN
cord-302047-vv5gpldi	199	21	RNA	RNA	NNP
cord-302047-vv5gpldi	199	22	viruses	virus	NNS
cord-302047-vv5gpldi	199	23	.	.	.
cord-302047-vv5gpldi	200	1	Although	although	IN
cord-302047-vv5gpldi	200	2	the	the	DT
cord-302047-vv5gpldi	200	3	RNA	RNA	NNP
cord-302047-vv5gpldi	200	4	viral	viral	JJ
cord-302047-vv5gpldi	200	5	vectors	vector	NNS
cord-302047-vv5gpldi	200	6	permitted	permit	VBD
cord-302047-vv5gpldi	200	7	the	the	DT
cord-302047-vv5gpldi	200	8	expression	expression	NN
cord-302047-vv5gpldi	200	9	of	of	IN
cord-302047-vv5gpldi	200	10	replaced	replace	VBN
cord-302047-vv5gpldi	200	11	genes	gene	NNS
cord-302047-vv5gpldi	200	12	,	,	,
cord-302047-vv5gpldi	200	13	either	either	CC
cord-302047-vv5gpldi	200	14	they	-PRON-	PRP
cord-302047-vv5gpldi	200	15	were	be	VBD
cord-302047-vv5gpldi	200	16	only	only	RB
cord-302047-vv5gpldi	200	17	viable	viable	JJ
cord-302047-vv5gpldi	200	18	in	in	IN
cord-302047-vv5gpldi	200	19	protoplasts	protoplast	NNS
cord-302047-vv5gpldi	200	20	and	and	CC
cord-302047-vv5gpldi	200	21	not	not	RB
cord-302047-vv5gpldi	200	22	in	in	IN
cord-302047-vv5gpldi	200	23	whole	whole	JJ
cord-302047-vv5gpldi	200	24	plants	plant	NNS
cord-302047-vv5gpldi	201	1	(	(	-LRB-
cord-302047-vv5gpldi	201	2	French	French	NNP
cord-302047-vv5gpldi	201	3	,	,	,
cord-302047-vv5gpldi	201	4	Janda	Janda	NNP
cord-302047-vv5gpldi	201	5	,	,	,
cord-302047-vv5gpldi	201	6	and	and	CC
cord-302047-vv5gpldi	201	7	Ahlquist	Ahlquist	NNP
cord-302047-vv5gpldi	201	8	1986	1986	CD
cord-302047-vv5gpldi	201	9	;	;	:
cord-302047-vv5gpldi	201	10	Joshi	Joshi	NNP
cord-302047-vv5gpldi	201	11	,	,	,
cord-302047-vv5gpldi	201	12	Joshi	Joshi	NNP
cord-302047-vv5gpldi	201	13	,	,	,
cord-302047-vv5gpldi	201	14	and	and	CC
cord-302047-vv5gpldi	201	15	Ow	Ow	NNP
cord-302047-vv5gpldi	201	16	1990	1990	CD
cord-302047-vv5gpldi	201	17	)	)	-RRB-
cord-302047-vv5gpldi	201	18	,	,	,
cord-302047-vv5gpldi	201	19	or	or	CC
cord-302047-vv5gpldi	201	20	they	-PRON-	PRP
cord-302047-vv5gpldi	201	21	were	be	VBD
cord-302047-vv5gpldi	201	22	unable	unable	JJ
cord-302047-vv5gpldi	201	23	to	to	TO
cord-302047-vv5gpldi	201	24	establish	establish	VB
cord-302047-vv5gpldi	201	25	systemic	systemic	JJ
cord-302047-vv5gpldi	201	26	infections	infection	NNS
cord-302047-vv5gpldi	201	27	(	(	-LRB-
cord-302047-vv5gpldi	201	28	Takamatsu	Takamatsu	NNP
cord-302047-vv5gpldi	201	29	et	et	FW
cord-302047-vv5gpldi	201	30	al	al	NNP
cord-302047-vv5gpldi	201	31	.	.	NNP
cord-302047-vv5gpldi	201	32	1987	1987	CD
cord-302047-vv5gpldi	201	33	;	;	:
cord-302047-vv5gpldi	201	34	Dawson	Dawson	NNP
cord-302047-vv5gpldi	201	35	,	,	,
cord-302047-vv5gpldi	201	36	Bubrick	Bubrick	NNP
cord-302047-vv5gpldi	201	37	,	,	,
cord-302047-vv5gpldi	201	38	and	and	CC
cord-302047-vv5gpldi	201	39	Grantham	Grantham	NNP
cord-302047-vv5gpldi	201	40	1988	1988	CD
cord-302047-vv5gpldi	201	41	)	)	-RRB-
cord-302047-vv5gpldi	201	42	.	.	.
cord-302047-vv5gpldi	202	1	Shortly	shortly	RB
cord-302047-vv5gpldi	202	2	after	after	RB
cord-302047-vv5gpldi	202	3	,	,	,
cord-302047-vv5gpldi	202	4	studies	study	NNS
cord-302047-vv5gpldi	202	5	showed	show	VBD
cord-302047-vv5gpldi	202	6	that	that	IN
cord-302047-vv5gpldi	202	7	gene	gene	NN
cord-302047-vv5gpldi	202	8	insertion	insertion	NN
cord-302047-vv5gpldi	202	9	-	-	:
cord-302047-vv5gpldi	202	10	rather	rather	RB
cord-302047-vv5gpldi	202	11	than	than	IN
cord-302047-vv5gpldi	202	12	gene	gene	NN
cord-302047-vv5gpldi	202	13	replacement	replacement	NN
cord-302047-vv5gpldi	202	14	-	-	:
cord-302047-vv5gpldi	202	15	was	be	VBD
cord-302047-vv5gpldi	202	16	better	well	RBR
cord-302047-vv5gpldi	202	17	suited	suit	VBN
cord-302047-vv5gpldi	202	18	for	for	IN
cord-302047-vv5gpldi	202	19	expressing	express	VBG
cord-302047-vv5gpldi	202	20	foreign	foreign	JJ
cord-302047-vv5gpldi	202	21	genes	gene	NNS
cord-302047-vv5gpldi	202	22	in	in	IN
cord-302047-vv5gpldi	202	23	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	202	24	)	)	-RRB-
cord-302047-vv5gpldi	202	25	viral	viral	JJ
cord-302047-vv5gpldi	202	26	genomes	genome	NNS
cord-302047-vv5gpldi	202	27	(	(	-LRB-
cord-302047-vv5gpldi	202	28	Dawson	Dawson	NNP
cord-302047-vv5gpldi	202	29	et	et	NNP
cord-302047-vv5gpldi	202	30	al	al	NNP
cord-302047-vv5gpldi	202	31	.	.	NNP
cord-302047-vv5gpldi	202	32	1989	1989	CD
cord-302047-vv5gpldi	202	33	;	;	:
cord-302047-vv5gpldi	202	34	Donson	Donson	NNP
cord-302047-vv5gpldi	202	35	et	et	NNP
cord-302047-vv5gpldi	202	36	al	al	NNP
cord-302047-vv5gpldi	202	37	.	.	.
cord-302047-vv5gpldi	203	1	1991	1991	CD
cord-302047-vv5gpldi	203	2	;	;	:
cord-302047-vv5gpldi	203	3	Chapman	Chapman	NNP
cord-302047-vv5gpldi	203	4	,	,	,
cord-302047-vv5gpldi	203	5	Kavanagh	Kavanagh	NNP
cord-302047-vv5gpldi	203	6	,	,	,
cord-302047-vv5gpldi	203	7	and	and	CC
cord-302047-vv5gpldi	203	8	Baulcombe	Baulcombe	NNP
cord-302047-vv5gpldi	203	9	1992	1992	CD
cord-302047-vv5gpldi	203	10	)	)	-RRB-
cord-302047-vv5gpldi	203	11	.	.	.
cord-302047-vv5gpldi	204	1	The	the	DT
cord-302047-vv5gpldi	204	2	chloramphenicol	chloramphenicol	NN
cord-302047-vv5gpldi	204	3	acetyltransferase	acetyltransferase	NN
cord-302047-vv5gpldi	204	4	(	(	-LRB-
cord-302047-vv5gpldi	204	5	CAT	CAT	NNP
cord-302047-vv5gpldi	204	6	)	)	-RRB-
cord-302047-vv5gpldi	204	7	gene	gene	NN
cord-302047-vv5gpldi	204	8	(	(	-LRB-
cord-302047-vv5gpldi	204	9	Dawson	Dawson	NNP
cord-302047-vv5gpldi	204	10	et	et	NNP
cord-302047-vv5gpldi	204	11	al	al	NNP
cord-302047-vv5gpldi	204	12	.	.	NNP
cord-302047-vv5gpldi	204	13	1989	1989	CD
cord-302047-vv5gpldi	204	14	)	)	-RRB-
cord-302047-vv5gpldi	204	15	,	,	,
cord-302047-vv5gpldi	204	16	and	and	CC
cord-302047-vv5gpldi	204	17	the	the	DT
cord-302047-vv5gpldi	204	18	dihydrofolate	dihydrofolate	NNP
cord-302047-vv5gpldi	204	19	reductase	reductase	NN
cord-302047-vv5gpldi	204	20	(	(	-LRB-
cord-302047-vv5gpldi	204	21	DHFR	DHFR	NNP
cord-302047-vv5gpldi	204	22	)	)	-RRB-
cord-302047-vv5gpldi	204	23	and	and	CC
cord-302047-vv5gpldi	204	24	the	the	DT
cord-302047-vv5gpldi	204	25	neomycin	neomycin	NN
cord-302047-vv5gpldi	204	26	phosphotransferase	phosphotransferase	NN
cord-302047-vv5gpldi	204	27	(	(	-LRB-
cord-302047-vv5gpldi	204	28	NPT	NPT	NNP
cord-302047-vv5gpldi	204	29	)	)	-RRB-
cord-302047-vv5gpldi	204	30	genes	gene	NNS
cord-302047-vv5gpldi	204	31	(	(	-LRB-
cord-302047-vv5gpldi	204	32	Donson	Donson	NNP
cord-302047-vv5gpldi	204	33	et	et	NNP
cord-302047-vv5gpldi	204	34	al	al	NNP
cord-302047-vv5gpldi	204	35	.	.	NNP
cord-302047-vv5gpldi	204	36	1991	1991	CD
cord-302047-vv5gpldi	204	37	)	)	-RRB-
cord-302047-vv5gpldi	204	38	were	be	VBD
cord-302047-vv5gpldi	204	39	successfully	successfully	RB
cord-302047-vv5gpldi	204	40	expressed	express	VBN
cord-302047-vv5gpldi	204	41	in	in	IN
cord-302047-vv5gpldi	204	42	plants	plant	NNS
cord-302047-vv5gpldi	204	43	by	by	IN
cord-302047-vv5gpldi	204	44	using	use	VBG
cord-302047-vv5gpldi	204	45	Tobacco	tobacco	NN
cord-302047-vv5gpldi	204	46	mosaic	mosaic	JJ
cord-302047-vv5gpldi	204	47	virus	virus	NN
cord-302047-vv5gpldi	204	48	(	(	-LRB-
cord-302047-vv5gpldi	204	49	TMV	TMV	NNP
cord-302047-vv5gpldi	204	50	)	)	-RRB-
cord-302047-vv5gpldi	204	51	as	as	IN
cord-302047-vv5gpldi	204	52	a	a	DT
cord-302047-vv5gpldi	204	53	vector	vector	NN
cord-302047-vv5gpldi	204	54	.	.	.
cord-302047-vv5gpldi	205	1	In	in	IN
cord-302047-vv5gpldi	205	2	addition	addition	NN
cord-302047-vv5gpldi	205	3	,	,	,
cord-302047-vv5gpldi	205	4	the	the	DT
cord-302047-vv5gpldi	205	5	bacterial	bacterial	JJ
cord-302047-vv5gpldi	205	6	GUS	GUS	NNP
cord-302047-vv5gpldi	205	7	gene	gene	NN
cord-302047-vv5gpldi	205	8	has	have	VBZ
cord-302047-vv5gpldi	205	9	shown	show	VBN
cord-302047-vv5gpldi	205	10	to	to	TO
cord-302047-vv5gpldi	205	11	successfully	successfully	RB
cord-302047-vv5gpldi	205	12	express	express	VB
cord-302047-vv5gpldi	205	13	when	when	WRB
cord-302047-vv5gpldi	205	14	inserted	insert	VBN
cord-302047-vv5gpldi	205	15	into	into	IN
cord-302047-vv5gpldi	205	16	the	the	DT
cord-302047-vv5gpldi	205	17	viral	viral	JJ
cord-302047-vv5gpldi	205	18	genome	genome	NN
cord-302047-vv5gpldi	205	19	of	of	IN
cord-302047-vv5gpldi	205	20	Potato	Potato	NNP
cord-302047-vv5gpldi	205	21	virus	virus	NN
cord-302047-vv5gpldi	205	22	X	x	NN
cord-302047-vv5gpldi	205	23	(	(	-LRB-
cord-302047-vv5gpldi	205	24	PVX	PVX	NNP
cord-302047-vv5gpldi	205	25	)	)	-RRB-
cord-302047-vv5gpldi	206	1	(	(	-LRB-
cord-302047-vv5gpldi	206	2	Chapman	Chapman	NNP
cord-302047-vv5gpldi	206	3	,	,	,
cord-302047-vv5gpldi	206	4	Kavanagh	Kavanagh	NNP
cord-302047-vv5gpldi	206	5	,	,	,
cord-302047-vv5gpldi	206	6	and	and	CC
cord-302047-vv5gpldi	206	7	Baulcombe	Baulcombe	NNP
cord-302047-vv5gpldi	206	8	1992	1992	CD
cord-302047-vv5gpldi	206	9	)	)	-RRB-
cord-302047-vv5gpldi	206	10	.	.	.
cord-302047-vv5gpldi	207	1	However	however	RB
cord-302047-vv5gpldi	207	2	,	,	,
cord-302047-vv5gpldi	207	3	in	in	IN
cord-302047-vv5gpldi	207	4	all	all	PDT
cord-302047-vv5gpldi	207	5	these	these	DT
cord-302047-vv5gpldi	207	6	cases	case	NNS
cord-302047-vv5gpldi	207	7	the	the	DT
cord-302047-vv5gpldi	207	8	presence	presence	NN
cord-302047-vv5gpldi	207	9	of	of	IN
cord-302047-vv5gpldi	207	10	a	a	DT
cord-302047-vv5gpldi	207	11	foreign	foreign	JJ
cord-302047-vv5gpldi	207	12	gene	gene	NN
cord-302047-vv5gpldi	207	13	leads	lead	VBZ
cord-302047-vv5gpldi	207	14	to	to	IN
cord-302047-vv5gpldi	207	15	genomic	genomic	JJ
cord-302047-vv5gpldi	207	16	instability	instability	NN
cord-302047-vv5gpldi	207	17	resulting	result	VBG
cord-302047-vv5gpldi	207	18	in	in	IN
cord-302047-vv5gpldi	207	19	the	the	DT
cord-302047-vv5gpldi	207	20	partial	partial	JJ
cord-302047-vv5gpldi	207	21	deletion	deletion	NN
cord-302047-vv5gpldi	207	22	of	of	IN
cord-302047-vv5gpldi	207	23	the	the	DT
cord-302047-vv5gpldi	207	24	GUS	GUS	NNP
cord-302047-vv5gpldi	207	25	and	and	CC
cord-302047-vv5gpldi	207	26	NPT	NPT	NNP
cord-302047-vv5gpldi	207	27	genes	gene	NNS
cord-302047-vv5gpldi	207	28	and	and	CC
cord-302047-vv5gpldi	207	29	a	a	DT
cord-302047-vv5gpldi	207	30	complete	complete	JJ
cord-302047-vv5gpldi	207	31	deletion	deletion	NN
cord-302047-vv5gpldi	207	32	of	of	IN
cord-302047-vv5gpldi	207	33	CAT	cat	NN
cord-302047-vv5gpldi	207	34	during	during	IN
cord-302047-vv5gpldi	207	35	systemic	systemic	JJ
cord-302047-vv5gpldi	207	36	infection	infection	NN
cord-302047-vv5gpldi	207	37	.	.	.
cord-302047-vv5gpldi	208	1	This	this	DT
cord-302047-vv5gpldi	208	2	instability	instability	NN
cord-302047-vv5gpldi	208	3	may	may	MD
cord-302047-vv5gpldi	208	4	result	result	VB
cord-302047-vv5gpldi	208	5	from	from	IN
cord-302047-vv5gpldi	208	6	the	the	DT
cord-302047-vv5gpldi	208	7	presence	presence	NN
cord-302047-vv5gpldi	208	8	of	of	IN
cord-302047-vv5gpldi	208	9	the	the	DT
cord-302047-vv5gpldi	208	10	insert	insert	NN
cord-302047-vv5gpldi	208	11	leading	lead	VBG
cord-302047-vv5gpldi	208	12	to	to	IN
cord-302047-vv5gpldi	208	13	lower	low	JJR
cord-302047-vv5gpldi	208	14	accumulation	accumulation	NN
cord-302047-vv5gpldi	208	15	levels	level	NNS
cord-302047-vv5gpldi	208	16	of	of	IN
cord-302047-vv5gpldi	208	17	the	the	DT
cord-302047-vv5gpldi	208	18	genomic	genomic	JJ
cord-302047-vv5gpldi	208	19	RNA	RNA	NNP
cord-302047-vv5gpldi	208	20	,	,	,
cord-302047-vv5gpldi	208	21	as	as	RB
cord-302047-vv5gpldi	208	22	well	well	RB
cord-302047-vv5gpldi	208	23	as	as	IN
cord-302047-vv5gpldi	208	24	leading	lead	VBG
cord-302047-vv5gpldi	208	25	to	to	IN
cord-302047-vv5gpldi	208	26	mRNA	mrna	NN
cord-302047-vv5gpldi	208	27	instability	instability	NN
cord-302047-vv5gpldi	208	28	and/or	and/or	CC
cord-302047-vv5gpldi	208	29	interfering	interfere	VBG
cord-302047-vv5gpldi	208	30	with	with	IN
cord-302047-vv5gpldi	208	31	synthesis	synthesis	NN
cord-302047-vv5gpldi	208	32	of	of	IN
cord-302047-vv5gpldi	208	33	the	the	DT
cord-302047-vv5gpldi	208	34	viral	viral	JJ
cord-302047-vv5gpldi	208	35	proteins	protein	NNS
cord-302047-vv5gpldi	208	36	.	.	.
cord-302047-vv5gpldi	209	1	Sequence	sequence	NN
cord-302047-vv5gpldi	209	2	redundancy	redundancy	NN
cord-302047-vv5gpldi	209	3	due	due	JJ
cord-302047-vv5gpldi	209	4	to	to	IN
cord-302047-vv5gpldi	209	5	a	a	DT
cord-302047-vv5gpldi	209	6	promoter	promoter	NN
cord-302047-vv5gpldi	209	7	duplication	duplication	NN
cord-302047-vv5gpldi	209	8	can	can	MD
cord-302047-vv5gpldi	209	9	also	also	RB
cord-302047-vv5gpldi	209	10	lead	lead	VB
cord-302047-vv5gpldi	209	11	to	to	IN
cord-302047-vv5gpldi	209	12	genomic	genomic	JJ
cord-302047-vv5gpldi	209	13	instability	instability	NN
cord-302047-vv5gpldi	209	14	and	and	CC
cord-302047-vv5gpldi	209	15	thus	thus	RB
cord-302047-vv5gpldi	209	16	the	the	DT
cord-302047-vv5gpldi	209	17	subsequent	subsequent	JJ
cord-302047-vv5gpldi	209	18	deletion	deletion	NN
cord-302047-vv5gpldi	209	19	of	of	IN
cord-302047-vv5gpldi	209	20	the	the	DT
cord-302047-vv5gpldi	209	21	inserted	insert	VBN
cord-302047-vv5gpldi	209	22	sequence	sequence	NN
cord-302047-vv5gpldi	209	23	(	(	-LRB-
cord-302047-vv5gpldi	209	24	Dawson	Dawson	NNP
cord-302047-vv5gpldi	209	25	et	et	NNP
cord-302047-vv5gpldi	209	26	al	al	NNP
cord-302047-vv5gpldi	209	27	.	.	NNP
cord-302047-vv5gpldi	209	28	1989	1989	CD
cord-302047-vv5gpldi	209	29	;	;	:
cord-302047-vv5gpldi	209	30	Chapman	Chapman	NNP
cord-302047-vv5gpldi	209	31	,	,	,
cord-302047-vv5gpldi	209	32	Kavanagh	Kavanagh	NNP
cord-302047-vv5gpldi	209	33	,	,	,
cord-302047-vv5gpldi	209	34	and	and	CC
cord-302047-vv5gpldi	209	35	Baulcombe	Baulcombe	NNP
cord-302047-vv5gpldi	209	36	1992	1992	CD
cord-302047-vv5gpldi	209	37	)	)	-RRB-
cord-302047-vv5gpldi	209	38	.	.	.
cord-302047-vv5gpldi	210	1	Indeed	indeed	RB
cord-302047-vv5gpldi	210	2	,	,	,
cord-302047-vv5gpldi	210	3	for	for	IN
cord-302047-vv5gpldi	210	4	TMV	TMV	NNP
cord-302047-vv5gpldi	210	5	and	and	CC
cord-302047-vv5gpldi	210	6	PVX	PVX	NNP
cord-302047-vv5gpldi	210	7	it	-PRON-	PRP
cord-302047-vv5gpldi	210	8	has	have	VBZ
cord-302047-vv5gpldi	210	9	been	be	VBN
cord-302047-vv5gpldi	210	10	shown	show	VBN
cord-302047-vv5gpldi	210	11	that	that	IN
cord-302047-vv5gpldi	210	12	replacing	replace	VBG
cord-302047-vv5gpldi	210	13	one	one	CD
cord-302047-vv5gpldi	210	14	of	of	IN
cord-302047-vv5gpldi	210	15	the	the	DT
cord-302047-vv5gpldi	210	16	promoter	promoter	NN
cord-302047-vv5gpldi	210	17	sequences	sequence	NNS
cord-302047-vv5gpldi	210	18	with	with	IN
cord-302047-vv5gpldi	210	19	that	that	DT
cord-302047-vv5gpldi	210	20	from	from	IN
cord-302047-vv5gpldi	210	21	related	related	JJ
cord-302047-vv5gpldi	210	22	viruses	virus	NNS
cord-302047-vv5gpldi	210	23	(	(	-LRB-
cord-302047-vv5gpldi	210	24	Donson	Donson	NNP
cord-302047-vv5gpldi	210	25	et	et	NNP
cord-302047-vv5gpldi	210	26	al	al	NNP
cord-302047-vv5gpldi	210	27	.	.	.
cord-302047-vv5gpldi	210	28	1991	1991	CD
cord-302047-vv5gpldi	210	29	)	)	-RRB-
cord-302047-vv5gpldi	210	30	together	together	RB
cord-302047-vv5gpldi	210	31	with	with	IN
cord-302047-vv5gpldi	210	32	further	further	JJ
cord-302047-vv5gpldi	210	33	removal	removal	NN
cord-302047-vv5gpldi	210	34	of	of	IN
cord-302047-vv5gpldi	210	35	additional	additional	JJ
cord-302047-vv5gpldi	210	36	sequence	sequence	NN
cord-302047-vv5gpldi	210	37	duplications	duplication	NNS
cord-302047-vv5gpldi	210	38	(	(	-LRB-
cord-302047-vv5gpldi	210	39	Dickmeis	Dickmeis	NNP
cord-302047-vv5gpldi	210	40	,	,	,
cord-302047-vv5gpldi	210	41	Fischer	Fischer	NNP
cord-302047-vv5gpldi	210	42	,	,	,
cord-302047-vv5gpldi	210	43	and	and	CC
cord-302047-vv5gpldi	210	44	Commandeur	Commandeur	NNP
cord-302047-vv5gpldi	210	45	2014	2014	CD
cord-302047-vv5gpldi	210	46	)	)	-RRB-
cord-302047-vv5gpldi	210	47	,	,	,
cord-302047-vv5gpldi	210	48	leads	lead	VBZ
cord-302047-vv5gpldi	210	49	to	to	IN
cord-302047-vv5gpldi	210	50	increased	increase	VBN
cord-302047-vv5gpldi	210	51	stability	stability	NN
cord-302047-vv5gpldi	210	52	of	of	IN
cord-302047-vv5gpldi	210	53	the	the	DT
cord-302047-vv5gpldi	210	54	insert	insert	NN
cord-302047-vv5gpldi	210	55	.	.	.
cord-302047-vv5gpldi	211	1	Interestingly	interestingly	RB
cord-302047-vv5gpldi	211	2	,	,	,
cord-302047-vv5gpldi	211	3	as	as	IN
cord-302047-vv5gpldi	211	4	for	for	IN
cord-302047-vv5gpldi	211	5	the	the	DT
cord-302047-vv5gpldi	211	6	DNA	dna	NN
cord-302047-vv5gpldi	211	7	viruses	virus	NNS
cord-302047-vv5gpldi	211	8	,	,	,
cord-302047-vv5gpldi	211	9	the	the	DT
cord-302047-vv5gpldi	211	10	site	site	NN
cord-302047-vv5gpldi	211	11	and	and	CC
cord-302047-vv5gpldi	211	12	size	size	NN
cord-302047-vv5gpldi	211	13	of	of	IN
cord-302047-vv5gpldi	211	14	the	the	DT
cord-302047-vv5gpldi	211	15	insert	insert	NN
cord-302047-vv5gpldi	211	16	seems	seem	VBZ
cord-302047-vv5gpldi	211	17	to	to	TO
cord-302047-vv5gpldi	211	18	be	be	VB
cord-302047-vv5gpldi	211	19	important	important	JJ
cord-302047-vv5gpldi	211	20	for	for	IN
cord-302047-vv5gpldi	211	21	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	211	22	)	)	-RRB-
cord-302047-vv5gpldi	211	23	viruses	virus	NNS
cord-302047-vv5gpldi	211	24	.	.	.
cord-302047-vv5gpldi	212	1	First	first	RB
cord-302047-vv5gpldi	212	2	,	,	,
cord-302047-vv5gpldi	212	3	the	the	DT
cord-302047-vv5gpldi	212	4	positioning	positioning	NN
cord-302047-vv5gpldi	212	5	of	of	IN
cord-302047-vv5gpldi	212	6	the	the	DT
cord-302047-vv5gpldi	212	7	CAT	cat	NN
cord-302047-vv5gpldi	212	8	gene	gene	NN
cord-302047-vv5gpldi	212	9	downstream	downstream	NN
cord-302047-vv5gpldi	212	10	(	(	-LRB-
cord-302047-vv5gpldi	212	11	instead	instead	RB
cord-302047-vv5gpldi	212	12	of	of	IN
cord-302047-vv5gpldi	212	13	upstream	upstream	NN
cord-302047-vv5gpldi	212	14	)	)	-RRB-
cord-302047-vv5gpldi	212	15	of	of	IN
cord-302047-vv5gpldi	212	16	the	the	DT
cord-302047-vv5gpldi	212	17	TMV	TMV	NNP
cord-302047-vv5gpldi	212	18	coat	coat	NN
cord-302047-vv5gpldi	212	19	protein	protein	NN
cord-302047-vv5gpldi	212	20	,	,	,
cord-302047-vv5gpldi	212	21	resulted	result	VBD
cord-302047-vv5gpldi	212	22	in	in	IN
cord-302047-vv5gpldi	212	23	a	a	DT
cord-302047-vv5gpldi	212	24	poorly	poorly	RB
cord-302047-vv5gpldi	212	25	replicating	replicate	VBG
cord-302047-vv5gpldi	212	26	virus	virus	NN
cord-302047-vv5gpldi	212	27	that	that	WDT
cord-302047-vv5gpldi	212	28	was	be	VBD
cord-302047-vv5gpldi	212	29	not	not	RB
cord-302047-vv5gpldi	212	30	able	able	JJ
cord-302047-vv5gpldi	212	31	to	to	TO
cord-302047-vv5gpldi	212	32	systematically	systematically	RB
cord-302047-vv5gpldi	212	33	infect	infect	VB
cord-302047-vv5gpldi	212	34	the	the	DT
cord-302047-vv5gpldi	212	35	host	host	NN
cord-302047-vv5gpldi	212	36	plants	plant	NNS
cord-302047-vv5gpldi	212	37	(	(	-LRB-
cord-302047-vv5gpldi	212	38	Dawson	Dawson	NNP
cord-302047-vv5gpldi	212	39	et	et	NNP
cord-302047-vv5gpldi	212	40	al	al	NNP
cord-302047-vv5gpldi	212	41	.	.	NNP
cord-302047-vv5gpldi	212	42	1989	1989	CD
cord-302047-vv5gpldi	212	43	)	)	-RRB-
cord-302047-vv5gpldi	212	44	.	.	.
cord-302047-vv5gpldi	213	1	And	and	CC
cord-302047-vv5gpldi	213	2	second	second	RB
cord-302047-vv5gpldi	213	3	,	,	,
cord-302047-vv5gpldi	213	4	the	the	DT
cord-302047-vv5gpldi	213	5	DHFR	DHFR	NNP
cord-302047-vv5gpldi	213	6	gene	gene	NN
cord-302047-vv5gpldi	213	7	(	(	-LRB-
cord-302047-vv5gpldi	213	8	238	238	CD
cord-302047-vv5gpldi	213	9	bp	bp	NNP
cord-302047-vv5gpldi	213	10	)	)	-RRB-
cord-302047-vv5gpldi	213	11	inserted	insert	VBD
cord-302047-vv5gpldi	213	12	in	in	IN
cord-302047-vv5gpldi	213	13	a	a	DT
cord-302047-vv5gpldi	213	14	TMV	TMV	NNP
cord-302047-vv5gpldi	213	15	background	background	NN
cord-302047-vv5gpldi	213	16	appears	appear	VBZ
cord-302047-vv5gpldi	213	17	to	to	TO
cord-302047-vv5gpldi	213	18	be	be	VB
cord-302047-vv5gpldi	213	19	maintained	maintain	VBN
cord-302047-vv5gpldi	213	20	stably	stably	RB
cord-302047-vv5gpldi	213	21	through	through	IN
cord-302047-vv5gpldi	213	22	several	several	JJ
cord-302047-vv5gpldi	213	23	passages	passage	NNS
cord-302047-vv5gpldi	213	24	,	,	,
cord-302047-vv5gpldi	213	25	while	while	IN
cord-302047-vv5gpldi	213	26	the	the	DT
cord-302047-vv5gpldi	213	27	3.5Â	3.5â	NN
cord-302047-vv5gpldi	213	28	larger	large	JJR
cord-302047-vv5gpldi	213	29	NPT	NPT	NNP
cord-302047-vv5gpldi	213	30	gene	gene	NN
cord-302047-vv5gpldi	213	31	(	(	-LRB-
cord-302047-vv5gpldi	213	32	832	832	CD
cord-302047-vv5gpldi	213	33	bp	bp	NNP
cord-302047-vv5gpldi	213	34	)	)	-RRB-
cord-302047-vv5gpldi	213	35	in	in	IN
cord-302047-vv5gpldi	213	36	the	the	DT
cord-302047-vv5gpldi	213	37	same	same	JJ
cord-302047-vv5gpldi	213	38	experimental	experimental	JJ
cord-302047-vv5gpldi	213	39	setup	setup	NN
cord-302047-vv5gpldi	213	40	was	be	VBD
cord-302047-vv5gpldi	213	41	unstable	unstable	JJ
cord-302047-vv5gpldi	213	42	during	during	IN
cord-302047-vv5gpldi	213	43	systemic	systemic	JJ
cord-302047-vv5gpldi	213	44	movement	movement	NN
cord-302047-vv5gpldi	213	45	of	of	IN
cord-302047-vv5gpldi	213	46	the	the	DT
cord-302047-vv5gpldi	213	47	virus	virus	NN
cord-302047-vv5gpldi	213	48	.	.	.
cord-302047-vv5gpldi	214	1	This	this	DT
cord-302047-vv5gpldi	214	2	may	may	MD
cord-302047-vv5gpldi	214	3	also	also	RB
cord-302047-vv5gpldi	214	4	be	be	VB
cord-302047-vv5gpldi	214	5	related	relate	VBN
cord-302047-vv5gpldi	214	6	to	to	IN
cord-302047-vv5gpldi	214	7	the	the	DT
cord-302047-vv5gpldi	214	8	nature	nature	NN
cord-302047-vv5gpldi	214	9	of	of	IN
cord-302047-vv5gpldi	214	10	the	the	DT
cord-302047-vv5gpldi	214	11	insert	insert	NN
cord-302047-vv5gpldi	214	12	,	,	,
cord-302047-vv5gpldi	214	13	where	where	WRB
cord-302047-vv5gpldi	214	14	sequences	sequence	NNS
cord-302047-vv5gpldi	214	15	with	with	IN
cord-302047-vv5gpldi	214	16	a	a	DT
cord-302047-vv5gpldi	214	17	codon	codon	NN
cord-302047-vv5gpldi	214	18	usage	usage	NN
cord-302047-vv5gpldi	214	19	similar	similar	JJ
cord-302047-vv5gpldi	214	20	to	to	IN
cord-302047-vv5gpldi	214	21	that	that	DT
cord-302047-vv5gpldi	214	22	of	of	IN
cord-302047-vv5gpldi	214	23	the	the	DT
cord-302047-vv5gpldi	214	24	viral	viral	JJ
cord-302047-vv5gpldi	214	25	vector	vector	NN
cord-302047-vv5gpldi	214	26	may	may	MD
cord-302047-vv5gpldi	214	27	be	be	VB
cord-302047-vv5gpldi	214	28	retained	retain	VBN
cord-302047-vv5gpldi	214	29	longer	long	RBR
cord-302047-vv5gpldi	214	30	than	than	IN
cord-302047-vv5gpldi	214	31	those	those	DT
cord-302047-vv5gpldi	214	32	that	that	WDT
cord-302047-vv5gpldi	214	33	have	have	VBP
cord-302047-vv5gpldi	214	34	an	an	DT
cord-302047-vv5gpldi	214	35	opposite	opposite	JJ
cord-302047-vv5gpldi	214	36	codon	codon	NN
cord-302047-vv5gpldi	214	37	usage	usage	NN
cord-302047-vv5gpldi	214	38	.	.	.
cord-302047-vv5gpldi	215	1	Interestingly	interestingly	RB
cord-302047-vv5gpldi	215	2	,	,	,
cord-302047-vv5gpldi	215	3	Chung	Chung	NNP
cord-302047-vv5gpldi	215	4	,	,	,
cord-302047-vv5gpldi	215	5	Canto	Canto	NNP
cord-302047-vv5gpldi	215	6	,	,	,
cord-302047-vv5gpldi	215	7	and	and	CC
cord-302047-vv5gpldi	215	8	Palukaitis	Palukaitis	NNP
cord-302047-vv5gpldi	215	9	(	(	-LRB-
cord-302047-vv5gpldi	215	10	2007	2007	CD
cord-302047-vv5gpldi	215	11	)	)	-RRB-
cord-302047-vv5gpldi	215	12	generated	generate	VBN
cord-302047-vv5gpldi	215	13	recombinant	recombinant	JJ
cord-302047-vv5gpldi	215	14	plant	plant	NN
cord-302047-vv5gpldi	215	15	viruses	virus	NNS
cord-302047-vv5gpldi	215	16	with	with	IN
cord-302047-vv5gpldi	215	17	inserted	insert	VBN
cord-302047-vv5gpldi	215	18	genes	gene	NNS
cord-302047-vv5gpldi	215	19	of	of	IN
cord-302047-vv5gpldi	215	20	unrelated	unrelated	JJ
cord-302047-vv5gpldi	215	21	plant	plant	NN
cord-302047-vv5gpldi	215	22	viruses	virus	NNS
cord-302047-vv5gpldi	215	23	and	and	CC
cord-302047-vv5gpldi	215	24	observed	observe	VBD
cord-302047-vv5gpldi	215	25	instability	instability	NN
cord-302047-vv5gpldi	215	26	and	and	CC
cord-302047-vv5gpldi	215	27	variation	variation	NN
cord-302047-vv5gpldi	215	28	in	in	IN
cord-302047-vv5gpldi	215	29	the	the	DT
cord-302047-vv5gpldi	215	30	rate	rate	NN
cord-302047-vv5gpldi	215	31	of	of	IN
cord-302047-vv5gpldi	215	32	partial	partial	JJ
cord-302047-vv5gpldi	215	33	or	or	CC
cord-302047-vv5gpldi	215	34	complete	complete	JJ
cord-302047-vv5gpldi	215	35	loss	loss	NN
cord-302047-vv5gpldi	215	36	of	of	IN
cord-302047-vv5gpldi	215	37	the	the	DT
cord-302047-vv5gpldi	215	38	insert	insert	NN
cord-302047-vv5gpldi	215	39	depending	depend	VBG
cord-302047-vv5gpldi	215	40	on	on	IN
cord-302047-vv5gpldi	215	41	the	the	DT
cord-302047-vv5gpldi	215	42	inserted	insert	VBN
cord-302047-vv5gpldi	215	43	sequence	sequence	NN
cord-302047-vv5gpldi	215	44	itself	-PRON-	PRP
cord-302047-vv5gpldi	215	45	,	,	,
cord-302047-vv5gpldi	215	46	the	the	DT
cord-302047-vv5gpldi	215	47	host	host	NN
cord-302047-vv5gpldi	215	48	used	use	VBN
cord-302047-vv5gpldi	215	49	,	,	,
cord-302047-vv5gpldi	215	50	or	or	CC
cord-302047-vv5gpldi	215	51	the	the	DT
cord-302047-vv5gpldi	215	52	viral	viral	JJ
cord-302047-vv5gpldi	215	53	vector	vector	NN
cord-302047-vv5gpldi	215	54	used	use	VBN
cord-302047-vv5gpldi	215	55	(	(	-LRB-
cord-302047-vv5gpldi	215	56	Chung	Chung	NNP
cord-302047-vv5gpldi	215	57	,	,	,
cord-302047-vv5gpldi	215	58	Canto	Canto	NNP
cord-302047-vv5gpldi	215	59	,	,	,
cord-302047-vv5gpldi	215	60	and	and	CC
cord-302047-vv5gpldi	215	61	Palukaitis	Palukaitis	NNP
cord-302047-vv5gpldi	215	62	2007	2007	CD
cord-302047-vv5gpldi	215	63	)	)	-RRB-
cord-302047-vv5gpldi	215	64	.	.	.
cord-302047-vv5gpldi	216	1	Also	also	RB
cord-302047-vv5gpldi	216	2	sequences	sequence	NNS
cord-302047-vv5gpldi	216	3	with	with	IN
cord-302047-vv5gpldi	216	4	a	a	DT
cord-302047-vv5gpldi	216	5	high	high	JJ
cord-302047-vv5gpldi	216	6	toxicity	toxicity	NN
cord-302047-vv5gpldi	216	7	for	for	IN
cord-302047-vv5gpldi	216	8	the	the	DT
cord-302047-vv5gpldi	216	9	host	host	NN
cord-302047-vv5gpldi	216	10	,	,	,
cord-302047-vv5gpldi	216	11	are	be	VBP
cord-302047-vv5gpldi	216	12	more	more	RBR
cord-302047-vv5gpldi	216	13	likely	likely	JJ
cord-302047-vv5gpldi	216	14	to	to	TO
cord-302047-vv5gpldi	216	15	become	become	VB
cord-302047-vv5gpldi	216	16	deleted	delete	VBN
cord-302047-vv5gpldi	216	17	faster	fast	RBR
cord-302047-vv5gpldi	216	18	or	or	CC
cord-302047-vv5gpldi	216	19	to	to	TO
cord-302047-vv5gpldi	216	20	impede	impede	VB
cord-302047-vv5gpldi	216	21	viral	viral	JJ
cord-302047-vv5gpldi	216	22	replication	replication	NN
cord-302047-vv5gpldi	216	23	.	.	.
cord-302047-vv5gpldi	217	1	In	in	IN
cord-302047-vv5gpldi	217	2	a	a	DT
cord-302047-vv5gpldi	217	3	previous	previous	JJ
cord-302047-vv5gpldi	217	4	study	study	NN
cord-302047-vv5gpldi	217	5	we	-PRON-	PRP
cord-302047-vv5gpldi	217	6	reported	report	VBD
cord-302047-vv5gpldi	217	7	on	on	IN
cord-302047-vv5gpldi	217	8	experimental	experimental	JJ
cord-302047-vv5gpldi	217	9	evolution	evolution	NN
cord-302047-vv5gpldi	217	10	of	of	IN
cord-302047-vv5gpldi	217	11	pseudogenization	pseudogenization	NN
cord-302047-vv5gpldi	217	12	in	in	IN
cord-302047-vv5gpldi	217	13	virus	virus	NN
cord-302047-vv5gpldi	217	14	genomes	genome	NNS
cord-302047-vv5gpldi	217	15	using	use	VBG
cord-302047-vv5gpldi	217	16	Tobacco	tobacco	NN
cord-302047-vv5gpldi	217	17	etch	etch	NN
cord-302047-vv5gpldi	217	18	virus	virus	NN
cord-302047-vv5gpldi	217	19	(	(	-LRB-
cord-302047-vv5gpldi	217	20	TEV	TEV	NNP
cord-302047-vv5gpldi	217	21	)	)	-RRB-
cord-302047-vv5gpldi	217	22	expressing	express	VBG
cord-302047-vv5gpldi	217	23	eGFP	eGFP	NNP
cord-302047-vv5gpldi	217	24	(	(	-LRB-
cord-302047-vv5gpldi	217	25	Zwart	Zwart	NNP
cord-302047-vv5gpldi	217	26	et	et	FW
cord-302047-vv5gpldi	217	27	al	al	NNP
cord-302047-vv5gpldi	217	28	.	.	NNP
cord-302047-vv5gpldi	217	29	2014	2014	CD
cord-302047-vv5gpldi	217	30	)	)	-RRB-
cord-302047-vv5gpldi	217	31	,	,	,
cord-302047-vv5gpldi	217	32	a	a	DT
cord-302047-vv5gpldi	217	33	gene	gene	NN
cord-302047-vv5gpldi	217	34	known	know	VBN
cord-302047-vv5gpldi	217	35	to	to	TO
cord-302047-vv5gpldi	217	36	be	be	VB
cord-302047-vv5gpldi	217	37	toxic	toxic	JJ
cord-302047-vv5gpldi	217	38	in	in	IN
cord-302047-vv5gpldi	217	39	many	many	JJ
cord-302047-vv5gpldi	217	40	expression	expression	NN
cord-302047-vv5gpldi	217	41	systems	system	NNS
cord-302047-vv5gpldi	217	42	.	.	.
cord-302047-vv5gpldi	218	1	In	in	IN
cord-302047-vv5gpldi	218	2	this	this	DT
cord-302047-vv5gpldi	218	3	case	case	NN
cord-302047-vv5gpldi	218	4	eGFP	egfp	NN
cord-302047-vv5gpldi	218	5	can	can	MD
cord-302047-vv5gpldi	218	6	be	be	VB
cord-302047-vv5gpldi	218	7	considered	consider	VBN
cord-302047-vv5gpldi	218	8	a	a	DT
cord-302047-vv5gpldi	218	9	non	non	JJ
cord-302047-vv5gpldi	218	10	-	-	JJ
cord-302047-vv5gpldi	218	11	functional	functional	JJ
cord-302047-vv5gpldi	218	12	sequence	sequence	NN
cord-302047-vv5gpldi	218	13	,	,	,
cord-302047-vv5gpldi	218	14	as	as	IN
cord-302047-vv5gpldi	218	15	it	-PRON-	PRP
cord-302047-vv5gpldi	218	16	does	do	VBZ
cord-302047-vv5gpldi	218	17	not	not	RB
cord-302047-vv5gpldi	218	18	add	add	VB
cord-302047-vv5gpldi	218	19	any	any	DT
cord-302047-vv5gpldi	218	20	function	function	NN
cord-302047-vv5gpldi	218	21	to	to	IN
cord-302047-vv5gpldi	218	22	the	the	DT
cord-302047-vv5gpldi	218	23	viral	viral	JJ
cord-302047-vv5gpldi	218	24	genome	genome	NN
cord-302047-vv5gpldi	218	25	.	.	.
cord-302047-vv5gpldi	219	1	We	-PRON-	PRP
cord-302047-vv5gpldi	219	2	showed	show	VBD
cord-302047-vv5gpldi	219	3	that	that	IN
cord-302047-vv5gpldi	219	4	eGFP	egfp	NN
cord-302047-vv5gpldi	219	5	has	have	VBZ
cord-302047-vv5gpldi	219	6	a	a	DT
cord-302047-vv5gpldi	219	7	high	high	JJ
cord-302047-vv5gpldi	219	8	fitness	fitness	NN
cord-302047-vv5gpldi	219	9	cost	cost	NN
cord-302047-vv5gpldi	219	10	in	in	IN
cord-302047-vv5gpldi	219	11	TEV	TEV	NNP
cord-302047-vv5gpldi	219	12	,	,	,
cord-302047-vv5gpldi	219	13	and	and	CC
cord-302047-vv5gpldi	219	14	the	the	DT
cord-302047-vv5gpldi	219	15	loss	loss	NN
cord-302047-vv5gpldi	219	16	of	of	IN
cord-302047-vv5gpldi	219	17	eGFP	egfp	NN
cord-302047-vv5gpldi	219	18	depended	depend	VBD
cord-302047-vv5gpldi	219	19	on	on	IN
cord-302047-vv5gpldi	219	20	the	the	DT
cord-302047-vv5gpldi	219	21	passage	passage	NN
cord-302047-vv5gpldi	219	22	length	length	NN
cord-302047-vv5gpldi	219	23	,	,	,
cord-302047-vv5gpldi	219	24	where	where	WRB
cord-302047-vv5gpldi	219	25	longer	long	JJR
cord-302047-vv5gpldi	219	26	passages	passage	NNS
cord-302047-vv5gpldi	219	27	led	lead	VBD
cord-302047-vv5gpldi	219	28	to	to	IN
cord-302047-vv5gpldi	219	29	a	a	DT
cord-302047-vv5gpldi	219	30	faster	fast	RBR
cord-302047-vv5gpldi	219	31	and	and	CC
cord-302047-vv5gpldi	219	32	assured	assure	VBN
cord-302047-vv5gpldi	219	33	loss	loss	NN
cord-302047-vv5gpldi	219	34	.	.	.
cord-302047-vv5gpldi	220	1	Similarly	similarly	RB
cord-302047-vv5gpldi	220	2	,	,	,
cord-302047-vv5gpldi	220	3	prolonged	prolonged	JJ
cord-302047-vv5gpldi	220	4	propagation	propagation	NN
cord-302047-vv5gpldi	220	5	of	of	IN
cord-302047-vv5gpldi	220	6	TEV	TEV	NNP
cord-302047-vv5gpldi	220	7	and	and	CC
cord-302047-vv5gpldi	220	8	plum	plum	NNP
cord-302047-vv5gpldi	220	9	pox	pox	NN
cord-302047-vv5gpldi	220	10	potyvirus	potyvirus	NNP
cord-302047-vv5gpldi	220	11	expressing	express	VBG
cord-302047-vv5gpldi	220	12	GUS	GUS	NNP
cord-302047-vv5gpldi	220	13	(	(	-LRB-
cord-302047-vv5gpldi	220	14	Dolja	Dolja	NNP
cord-302047-vv5gpldi	220	15	,	,	,
cord-302047-vv5gpldi	220	16	McBride	McBride	NNP
cord-302047-vv5gpldi	220	17	,	,	,
cord-302047-vv5gpldi	220	18	and	and	CC
cord-302047-vv5gpldi	220	19	Carrington	Carrington	NNP
cord-302047-vv5gpldi	220	20	1992	1992	CD
cord-302047-vv5gpldi	220	21	;	;	:
cord-302047-vv5gpldi	221	1	Dolja	Dolja	NNP
cord-302047-vv5gpldi	221	2	et	et	FW
cord-302047-vv5gpldi	221	3	al	al	NNP
cord-302047-vv5gpldi	221	4	.	.	.
cord-302047-vv5gpldi	222	1	1993	1993	CD
cord-302047-vv5gpldi	222	2	;	;	:
cord-302047-vv5gpldi	222	3	Guo	Guo	NNP
cord-302047-vv5gpldi	222	4	,	,	,
cord-302047-vv5gpldi	222	5	Ló	Ló	NNP
cord-302047-vv5gpldi	222	6	pez	pez	NNP
cord-302047-vv5gpldi	222	7	-	-	HYPH
cord-302047-vv5gpldi	222	8	Moya	Moya	NNP
cord-302047-vv5gpldi	222	9	,	,	,
cord-302047-vv5gpldi	222	10	and	and	CC
cord-302047-vv5gpldi	222	11	García	García	NNP
cord-302047-vv5gpldi	222	12	1998	1998	CD
cord-302047-vv5gpldi	222	13	)	)	-RRB-
cord-302047-vv5gpldi	222	14	,	,	,
cord-302047-vv5gpldi	222	15	and	and	CC
cord-302047-vv5gpldi	222	16	TMV	TMV	NNP
cord-302047-vv5gpldi	222	17	expressing	express	VBG
cord-302047-vv5gpldi	222	18	GFP	GFP	NNP
cord-302047-vv5gpldi	222	19	(	(	-LRB-
cord-302047-vv5gpldi	222	20	Rabindran	Rabindran	NNP
cord-302047-vv5gpldi	222	21	and	and	CC
cord-302047-vv5gpldi	222	22	Dawson	Dawson	NNP
cord-302047-vv5gpldi	222	23	2001	2001	CD
cord-302047-vv5gpldi	222	24	)	)	-RRB-
cord-302047-vv5gpldi	222	25	,	,	,
cord-302047-vv5gpldi	222	26	led	lead	VBD
cord-302047-vv5gpldi	222	27	to	to	IN
cord-302047-vv5gpldi	222	28	the	the	DT
cord-302047-vv5gpldi	222	29	appearance	appearance	NN
cord-302047-vv5gpldi	222	30	of	of	IN
cord-302047-vv5gpldi	222	31	spontaneous	spontaneous	JJ
cord-302047-vv5gpldi	222	32	deletion	deletion	NN
cord-302047-vv5gpldi	222	33	variants	variant	NNS
cord-302047-vv5gpldi	222	34	.	.	.
cord-302047-vv5gpldi	223	1	Due	due	IN
cord-302047-vv5gpldi	223	2	to	to	IN
cord-302047-vv5gpldi	223	3	the	the	DT
cord-302047-vv5gpldi	223	4	increase	increase	NN
cord-302047-vv5gpldi	223	5	in	in	IN
cord-302047-vv5gpldi	223	6	genome	genome	NN
cord-302047-vv5gpldi	223	7	size	size	NN
cord-302047-vv5gpldi	223	8	,	,	,
cord-302047-vv5gpldi	223	9	viruses	virus	NNS
cord-302047-vv5gpldi	223	10	that	that	WDT
cord-302047-vv5gpldi	223	11	carry	carry	VBP
cord-302047-vv5gpldi	223	12	an	an	DT
cord-302047-vv5gpldi	223	13	insert	insert	NN
cord-302047-vv5gpldi	223	14	are	be	VBP
cord-302047-vv5gpldi	223	15	unlikely	unlikely	JJ
cord-302047-vv5gpldi	223	16	to	to	TO
cord-302047-vv5gpldi	223	17	be	be	VB
cord-302047-vv5gpldi	223	18	as	as	RB
cord-302047-vv5gpldi	223	19	fit	fit	JJ
cord-302047-vv5gpldi	223	20	as	as	IN
cord-302047-vv5gpldi	223	21	the	the	DT
cord-302047-vv5gpldi	223	22	parental	parental	JJ
cord-302047-vv5gpldi	223	23	(	(	-LRB-
cord-302047-vv5gpldi	223	24	ancestral	ancestral	JJ
cord-302047-vv5gpldi	223	25	)	)	-RRB-
cord-302047-vv5gpldi	223	26	virus	virus	NN
cord-302047-vv5gpldi	223	27	,	,	,
cord-302047-vv5gpldi	223	28	even	even	RB
cord-302047-vv5gpldi	223	29	if	if	IN
cord-302047-vv5gpldi	223	30	they	-PRON-	PRP
cord-302047-vv5gpldi	223	31	accumulate	accumulate	VBP
cord-302047-vv5gpldi	223	32	initially	initially	RB
cord-302047-vv5gpldi	223	33	to	to	IN
cord-302047-vv5gpldi	223	34	similar	similar	JJ
cord-302047-vv5gpldi	223	35	levels	level	NNS
cord-302047-vv5gpldi	223	36	.	.	.
cord-302047-vv5gpldi	224	1	The	the	DT
cord-302047-vv5gpldi	224	2	TEV	TEV	NNP
cord-302047-vv5gpldi	224	3	-	-	HYPH
cord-302047-vv5gpldi	224	4	eGFP	eGFP	NNP
cord-302047-vv5gpldi	224	5	genomes	genome	NNS
cord-302047-vv5gpldi	224	6	that	that	WDT
cord-302047-vv5gpldi	224	7	had	have	VBD
cord-302047-vv5gpldi	224	8	lost	lose	VBN
cord-302047-vv5gpldi	224	9	the	the	DT
cord-302047-vv5gpldi	224	10	insert	insert	NN
cord-302047-vv5gpldi	224	11	had	have	VBD
cord-302047-vv5gpldi	224	12	a	a	DT
cord-302047-vv5gpldi	224	13	within	within	RB
cord-302047-vv5gpldi	224	14	-	-	HYPH
cord-302047-vv5gpldi	224	15	host	host	NN
cord-302047-vv5gpldi	224	16	competitive	competitive	JJ
cord-302047-vv5gpldi	224	17	fitness	fitness	NN
cord-302047-vv5gpldi	224	18	advantage	advantage	NN
cord-302047-vv5gpldi	224	19	,	,	,
cord-302047-vv5gpldi	224	20	where	where	WRB
cord-302047-vv5gpldi	224	21	the	the	DT
cord-302047-vv5gpldi	224	22	smaller	small	JJR
cord-302047-vv5gpldi	224	23	the	the	DT
cord-302047-vv5gpldi	224	24	genome	genome	NN
cord-302047-vv5gpldi	224	25	the	the	DT
cord-302047-vv5gpldi	224	26	higher	high	JJR
cord-302047-vv5gpldi	224	27	the	the	DT
cord-302047-vv5gpldi	224	28	within	within	IN
cord-302047-vv5gpldi	224	29	-	-	HYPH
cord-302047-vv5gpldi	224	30	host	host	NN
cord-302047-vv5gpldi	224	31	competitive	competitive	JJ
cord-302047-vv5gpldi	224	32	fitness	fitness	NN
cord-302047-vv5gpldi	224	33	.	.	.
cord-302047-vv5gpldi	225	1	Interestingly	interestingly	RB
cord-302047-vv5gpldi	225	2	,	,	,
cord-302047-vv5gpldi	225	3	although	although	IN
cord-302047-vv5gpldi	225	4	the	the	DT
cord-302047-vv5gpldi	225	5	size	size	NN
cord-302047-vv5gpldi	225	6	of	of	IN
cord-302047-vv5gpldi	225	7	the	the	DT
cord-302047-vv5gpldi	225	8	deletions	deletion	NNS
cord-302047-vv5gpldi	225	9	varied	vary	VBN
cord-302047-vv5gpldi	225	10	,	,	,
cord-302047-vv5gpldi	225	11	convergent	convergent	JJ
cord-302047-vv5gpldi	225	12	evolution	evolution	NN
cord-302047-vv5gpldi	225	13	did	do	VBD
cord-302047-vv5gpldi	225	14	occur	occur	VB
cord-302047-vv5gpldi	225	15	in	in	IN
cord-302047-vv5gpldi	225	16	terms	term	NNS
cord-302047-vv5gpldi	225	17	of	of	IN
cord-302047-vv5gpldi	225	18	fixed	fix	VBN
cord-302047-vv5gpldi	225	19	point	point	NN
cord-302047-vv5gpldi	225	20	mutations	mutation	NNS
cord-302047-vv5gpldi	225	21	(	(	-LRB-
cord-302047-vv5gpldi	225	22	Zwart	Zwart	NNP
cord-302047-vv5gpldi	225	23	et	et	FW
cord-302047-vv5gpldi	225	24	al	al	NNP
cord-302047-vv5gpldi	225	25	.	.	NNP
cord-302047-vv5gpldi	225	26	2014	2014	CD
cord-302047-vv5gpldi	225	27	)	)	-RRB-
cord-302047-vv5gpldi	225	28	.	.	.
cord-302047-vv5gpldi	226	1	This	this	DT
cord-302047-vv5gpldi	226	2	result	result	NN
cord-302047-vv5gpldi	226	3	also	also	RB
cord-302047-vv5gpldi	226	4	suggests	suggest	VBZ
cord-302047-vv5gpldi	226	5	that	that	IN
cord-302047-vv5gpldi	226	6	a	a	DT
cord-302047-vv5gpldi	226	7	demographic	demographic	JJ
cord-302047-vv5gpldi	226	8	'	'	``
cord-302047-vv5gpldi	226	9	sweet	sweet	JJ
cord-302047-vv5gpldi	226	10	spot	spot	NN
cord-302047-vv5gpldi	226	11	'	'	''
cord-302047-vv5gpldi	226	12	exists	exist	VBZ
cord-302047-vv5gpldi	226	13	,	,	,
cord-302047-vv5gpldi	226	14	where	where	WRB
cord-302047-vv5gpldi	226	15	heterologous	heterologous	JJ
cord-302047-vv5gpldi	226	16	insertions	insertion	NNS
cord-302047-vv5gpldi	226	17	are	be	VBP
cord-302047-vv5gpldi	226	18	not	not	RB
cord-302047-vv5gpldi	226	19	immediately	immediately	RB
cord-302047-vv5gpldi	226	20	lost	lose	VBN
cord-302047-vv5gpldi	226	21	while	while	IN
cord-302047-vv5gpldi	226	22	evolution	evolution	NN
cord-302047-vv5gpldi	226	23	can	can	MD
cord-302047-vv5gpldi	226	24	act	act	VB
cord-302047-vv5gpldi	226	25	to	to	TO
cord-302047-vv5gpldi	226	26	integrate	integrate	VB
cord-302047-vv5gpldi	226	27	them	-PRON-	PRP
cord-302047-vv5gpldi	226	28	into	into	IN
cord-302047-vv5gpldi	226	29	the	the	DT
cord-302047-vv5gpldi	226	30	viral	viral	JJ
cord-302047-vv5gpldi	226	31	genome	genome	NN
cord-302047-vv5gpldi	226	32	.	.	.
cord-302047-vv5gpldi	227	1	In	in	IN
cord-302047-vv5gpldi	227	2	summary	summary	NN
cord-302047-vv5gpldi	227	3	,	,	,
cord-302047-vv5gpldi	227	4	in	in	IN
cord-302047-vv5gpldi	227	5	several	several	JJ
cord-302047-vv5gpldi	227	6	studies	study	NNS
cord-302047-vv5gpldi	227	7	passage	passage	NN
cord-302047-vv5gpldi	227	8	duration	duration	NN
cord-302047-vv5gpldi	227	9	has	have	VBZ
cord-302047-vv5gpldi	227	10	an	an	DT
cord-302047-vv5gpldi	227	11	effect	effect	NN
cord-302047-vv5gpldi	227	12	on	on	IN
cord-302047-vv5gpldi	227	13	insert	insert	JJ
cord-302047-vv5gpldi	227	14	stability	stability	NN
cord-302047-vv5gpldi	227	15	,	,	,
cord-302047-vv5gpldi	227	16	with	with	IN
cord-302047-vv5gpldi	227	17	inserts	insert	NNS
cord-302047-vv5gpldi	227	18	being	be	VBG
cord-302047-vv5gpldi	227	19	more	more	RBR
cord-302047-vv5gpldi	227	20	stable	stable	JJ
cord-302047-vv5gpldi	227	21	in	in	IN
cord-302047-vv5gpldi	227	22	shorter	short	JJR
cord-302047-vv5gpldi	227	23	passages	passage	NNS
cord-302047-vv5gpldi	227	24	.	.	.
cord-302047-vv5gpldi	228	1	We	-PRON-	PRP
cord-302047-vv5gpldi	228	2	explore	explore	VBP
cord-302047-vv5gpldi	228	3	these	these	DT
cord-302047-vv5gpldi	228	4	effects	effect	NNS
cord-302047-vv5gpldi	228	5	in	in	IN
cord-302047-vv5gpldi	228	6	the	the	DT
cord-302047-vv5gpldi	228	7	conceptual	conceptual	JJ
cord-302047-vv5gpldi	228	8	section	section	NN
cord-302047-vv5gpldi	228	9	presented	present	VBN
cord-302047-vv5gpldi	228	10	at	at	IN
cord-302047-vv5gpldi	228	11	the	the	DT
cord-302047-vv5gpldi	228	12	end	end	NN
cord-302047-vv5gpldi	228	13	of	of	IN
cord-302047-vv5gpldi	228	14	this	this	DT
cord-302047-vv5gpldi	228	15	paper	paper	NN
cord-302047-vv5gpldi	228	16	(	(	-LRB-
cord-302047-vv5gpldi	228	17	see	see	VB
cord-302047-vv5gpldi	228	18	also	also	RB
cord-302047-vv5gpldi	228	19	Box	Box	NNP
cord-302047-vv5gpldi	228	20	1	1	CD
cord-302047-vv5gpldi	228	21	)	)	-RRB-
cord-302047-vv5gpldi	228	22	.	.	.
cord-302047-vv5gpldi	229	1	Here	here	RB
cord-302047-vv5gpldi	229	2	we	-PRON-	PRP
cord-302047-vv5gpldi	229	3	illustrate	illustrate	VBP
cord-302047-vv5gpldi	229	4	how	how	WRB
cord-302047-vv5gpldi	229	5	demography	demography	NN
cord-302047-vv5gpldi	229	6	can	can	MD
cord-302047-vv5gpldi	229	7	affect	affect	VB
cord-302047-vv5gpldi	229	8	the	the	DT
cord-302047-vv5gpldi	229	9	observed	observed	JJ
cord-302047-vv5gpldi	229	10	stability	stability	NN
cord-302047-vv5gpldi	229	11	of	of	IN
cord-302047-vv5gpldi	229	12	an	an	DT
cord-302047-vv5gpldi	229	13	inserted	insert	VBN
cord-302047-vv5gpldi	229	14	sequence	sequence	NN
cord-302047-vv5gpldi	229	15	,	,	,
cord-302047-vv5gpldi	229	16	using	use	VBG
cord-302047-vv5gpldi	229	17	a	a	DT
cord-302047-vv5gpldi	229	18	simulation	simulation	NN
cord-302047-vv5gpldi	229	19	model	model	NN
cord-302047-vv5gpldi	229	20	.	.	.
cord-302047-vv5gpldi	230	1	This	this	DT
cord-302047-vv5gpldi	230	2	model	model	NN
cord-302047-vv5gpldi	230	3	is	be	VBZ
cord-302047-vv5gpldi	230	4	based	base	VBN
cord-302047-vv5gpldi	230	5	on	on	IN
cord-302047-vv5gpldi	230	6	(	(	-LRB-
cord-302047-vv5gpldi	230	7	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	230	8	et	et	NNP
cord-302047-vv5gpldi	230	9	al	al	NNP
cord-302047-vv5gpldi	230	10	.	.	.
cord-302047-vv5gpldi	230	11	2016	2016	CD
cord-302047-vv5gpldi	230	12	)	)	-RRB-
cord-302047-vv5gpldi	230	13	and	and	CC
cord-302047-vv5gpldi	230	14	incorporates	incorporate	VBZ
cord-302047-vv5gpldi	230	15	logistic	logistic	JJ
cord-302047-vv5gpldi	230	16	virus	virus	NN
cord-302047-vv5gpldi	230	17	growth	growth	NN
cord-302047-vv5gpldi	230	18	,	,	,
cord-302047-vv5gpldi	230	19	deterministic	deterministic	JJ
cord-302047-vv5gpldi	230	20	recombination	recombination	NN
cord-302047-vv5gpldi	230	21	with	with	IN
cord-302047-vv5gpldi	230	22	a	a	DT
cord-302047-vv5gpldi	230	23	fixed	fix	VBN
cord-302047-vv5gpldi	230	24	rate	rate	NN
cord-302047-vv5gpldi	230	25	,	,	,
cord-302047-vv5gpldi	230	26	and	and	CC
cord-302047-vv5gpldi	230	27	population	population	NN
cord-302047-vv5gpldi	230	28	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	230	29	after	after	IN
cord-302047-vv5gpldi	230	30	a	a	DT
cord-302047-vv5gpldi	230	31	given	give	VBN
cord-302047-vv5gpldi	230	32	number	number	NN
cord-302047-vv5gpldi	230	33	of	of	IN
cord-302047-vv5gpldi	230	34	generations	generation	NNS
cord-302047-vv5gpldi	230	35	.	.	.
cord-302047-vv5gpldi	231	1	To	to	TO
cord-302047-vv5gpldi	231	2	describe	describe	VB
cord-302047-vv5gpldi	231	3	virus	virus	NN
cord-302047-vv5gpldi	231	4	growth	growth	NN
cord-302047-vv5gpldi	231	5	and	and	CC
cord-302047-vv5gpldi	231	6	recombination	recombination	NN
cord-302047-vv5gpldi	231	7	in	in	IN
cord-302047-vv5gpldi	231	8	each	each	DT
cord-302047-vv5gpldi	231	9	generation	generation	NN
cord-302047-vv5gpldi	231	10	,	,	,
cord-302047-vv5gpldi	231	11	two	two	CD
cord-302047-vv5gpldi	231	12	coupled	couple	VBN
cord-302047-vv5gpldi	231	13	ordinary	ordinary	JJ
cord-302047-vv5gpldi	231	14	differential	differential	JJ
cord-302047-vv5gpldi	231	15	equations	equation	NNS
cord-302047-vv5gpldi	231	16	are	be	VBP
cord-302047-vv5gpldi	231	17	used	use	VBN
cord-302047-vv5gpldi	231	18	:	:	:
cord-302047-vv5gpldi	231	19	Here	here	RB
cord-302047-vv5gpldi	231	20	,	,	,
cord-302047-vv5gpldi	231	21	I	-PRON-	PRP
cord-302047-vv5gpldi	231	22	is	be	VBZ
cord-302047-vv5gpldi	231	23	the	the	DT
cord-302047-vv5gpldi	231	24	number	number	NN
cord-302047-vv5gpldi	231	25	of	of	IN
cord-302047-vv5gpldi	231	26	viruses	virus	NNS
cord-302047-vv5gpldi	231	27	with	with	IN
cord-302047-vv5gpldi	231	28	the	the	DT
cord-302047-vv5gpldi	231	29	insertion	insertion	NN
cord-302047-vv5gpldi	231	30	intact	intact	JJ
cord-302047-vv5gpldi	231	31	,	,	,
cord-302047-vv5gpldi	231	32	D	D	NNP
cord-302047-vv5gpldi	231	33	is	be	VBZ
cord-302047-vv5gpldi	231	34	the	the	DT
cord-302047-vv5gpldi	231	35	number	number	NN
cord-302047-vv5gpldi	231	36	of	of	IN
cord-302047-vv5gpldi	231	37	viruses	virus	NNS
cord-302047-vv5gpldi	231	38	with	with	IN
cord-302047-vv5gpldi	231	39	a	a	DT
cord-302047-vv5gpldi	231	40	deletion	deletion	NN
cord-302047-vv5gpldi	231	41	,	,	,
cord-302047-vv5gpldi	231	42	x	x	NN
cord-302047-vv5gpldi	231	43	is	be	VBZ
cord-302047-vv5gpldi	231	44	initial	initial	JJ
cord-302047-vv5gpldi	231	45	growth	growth	NN
cord-302047-vv5gpldi	231	46	rate	rate	NN
cord-302047-vv5gpldi	231	47	of	of	IN
cord-302047-vv5gpldi	231	48	each	each	DT
cord-302047-vv5gpldi	231	49	virus	virus	NN
cord-302047-vv5gpldi	231	50	variant	variant	NN
cord-302047-vv5gpldi	231	51	,	,	,
cord-302047-vv5gpldi	231	52	j	j	NNP
cord-302047-vv5gpldi	231	53	is	be	VBZ
cord-302047-vv5gpldi	231	54	the	the	DT
cord-302047-vv5gpldi	231	55	carrying	carrying	NN
cord-302047-vv5gpldi	231	56	capacity	capacity	NN
cord-302047-vv5gpldi	231	57	,	,	,
cord-302047-vv5gpldi	231	58	q	q	NNP
cord-302047-vv5gpldi	231	59	is	be	VBZ
cord-302047-vv5gpldi	231	60	the	the	DT
cord-302047-vv5gpldi	231	61	rate	rate	NN
cord-302047-vv5gpldi	231	62	at	at	IN
cord-302047-vv5gpldi	231	63	which	which	WDT
cord-302047-vv5gpldi	231	64	I	-PRON-	PRP
cord-302047-vv5gpldi	231	65	recombines	recombine	VBZ
cord-302047-vv5gpldi	231	66	to	to	IN
cord-302047-vv5gpldi	231	67	D	D	NNP
cord-302047-vv5gpldi	231	68	,	,	,
cord-302047-vv5gpldi	231	69	and	and	CC
cord-302047-vv5gpldi	231	70	w	w	NN
cord-302047-vv5gpldi	231	71	is	be	VBZ
cord-302047-vv5gpldi	231	72	a	a	DT
cord-302047-vv5gpldi	231	73	constant	constant	NN
cord-302047-vv5gpldi	231	74	for	for	IN
cord-302047-vv5gpldi	231	75	determining	determine	VBG
cord-302047-vv5gpldi	231	76	the	the	DT
cord-302047-vv5gpldi	231	77	effect	effect	NN
cord-302047-vv5gpldi	231	78	of	of	IN
cord-302047-vv5gpldi	231	79	each	each	DT
cord-302047-vv5gpldi	231	80	virus	virus	NN
cord-302047-vv5gpldi	231	81	on	on	IN
cord-302047-vv5gpldi	231	82	the	the	DT
cord-302047-vv5gpldi	231	83	others	other	NNS
cord-302047-vv5gpldi	231	84	replication	replication	NN
cord-302047-vv5gpldi	231	85	,	,	,
cord-302047-vv5gpldi	231	86	with	with	IN
cord-302047-vv5gpldi	231	87	the	the	DT
cord-302047-vv5gpldi	231	88	effect	effect	NN
cord-302047-vv5gpldi	231	89	of	of	IN
cord-302047-vv5gpldi	231	90	D	d	NN
cord-302047-vv5gpldi	231	91	on	on	IN
cord-302047-vv5gpldi	231	92	I	-PRON-	PRP
cord-302047-vv5gpldi	231	93	being	be	VBG
cord-302047-vv5gpldi	231	94	w	w	NN
cord-302047-vv5gpldi	232	1	D	D	NNP
cord-302047-vv5gpldi	232	2	¼	¼	NNP
cord-302047-vv5gpldi	232	3	x	x	SYM
cord-302047-vv5gpldi	232	4	D	d	NN
cord-302047-vv5gpldi	232	5	=	=	NN
cord-302047-vv5gpldi	233	1	x	x	LS
cord-302047-vv5gpldi	234	1	I	-PRON-	PRP
cord-302047-vv5gpldi	234	2	and	and	CC
cord-302047-vv5gpldi	234	3	vice	vice	NN
cord-302047-vv5gpldi	234	4	versa	versa	RB
cord-302047-vv5gpldi	235	1	w	w	NNP
cord-302047-vv5gpldi	236	1	I	-PRON-	PRP
cord-302047-vv5gpldi	236	2	¼	¼	CD
cord-302047-vv5gpldi	236	3	1	1	CD
cord-302047-vv5gpldi	237	1	=	=	SYM
cord-302047-vv5gpldi	237	2	w	w	NN
cord-302047-vv5gpldi	237	3	D	D	NNP
cord-302047-vv5gpldi	237	4	.	.	.
cord-302047-vv5gpldi	238	1	The	the	DT
cord-302047-vv5gpldi	238	2	frequency	frequency	NN
cord-302047-vv5gpldi	238	3	of	of	IN
cord-302047-vv5gpldi	238	4	the	the	DT
cord-302047-vv5gpldi	238	5	deletion	deletion	NN
cord-302047-vv5gpldi	238	6	variant	variant	NN
cord-302047-vv5gpldi	238	7	is	be	VBZ
cord-302047-vv5gpldi	238	8	At	at	IN
cord-302047-vv5gpldi	238	9	the	the	DT
cord-302047-vv5gpldi	238	10	start	start	NN
cord-302047-vv5gpldi	238	11	of	of	IN
cord-302047-vv5gpldi	238	12	each	each	DT
cord-302047-vv5gpldi	238	13	passage	passage	NN
cord-302047-vv5gpldi	238	14	,	,	,
cord-302047-vv5gpldi	238	15	to	to	TO
cord-302047-vv5gpldi	238	16	simulate	simulate	VB
cord-302047-vv5gpldi	238	17	the	the	DT
cord-302047-vv5gpldi	238	18	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	238	19	we	-PRON-	PRP
cord-302047-vv5gpldi	238	20	draw	draw	VBP
cord-302047-vv5gpldi	238	21	the	the	DT
cord-302047-vv5gpldi	238	22	number	number	NN
cord-302047-vv5gpldi	238	23	I	-PRON-	PRP
cord-302047-vv5gpldi	238	24	from	from	IN
cord-302047-vv5gpldi	238	25	a	a	DT
cord-302047-vv5gpldi	238	26	Binomial	binomial	JJ
cord-302047-vv5gpldi	238	27	distribution	distribution	NN
cord-302047-vv5gpldi	238	28	with	with	IN
cord-302047-vv5gpldi	238	29	a	a	DT
cord-302047-vv5gpldi	238	30	size	size	NN
cord-302047-vv5gpldi	238	31	a	a	NN
cord-302047-vv5gpldi	238	32	and	and	CC
cord-302047-vv5gpldi	238	33	success	success	NN
cord-302047-vv5gpldi	238	34	probability	probability	NN
cord-302047-vv5gpldi	238	35	f	f	NN
cord-302047-vv5gpldi	238	36	D	D	NNP
cord-302047-vv5gpldi	238	37	from	from	IN
cord-302047-vv5gpldi	238	38	the	the	DT
cord-302047-vv5gpldi	238	39	previous	previous	JJ
cord-302047-vv5gpldi	238	40	time	time	NN
cord-302047-vv5gpldi	238	41	point	point	NN
cord-302047-vv5gpldi	238	42	,	,	,
cord-302047-vv5gpldi	238	43	and	and	CC
cord-302047-vv5gpldi	238	44	then	then	RB
cord-302047-vv5gpldi	238	45	D	D	NNP
cord-302047-vv5gpldi	238	46	¼	¼	FW
cord-302047-vv5gpldi	238	47	a	a	FW
cord-302047-vv5gpldi	238	48	À	à	NN
cord-302047-vv5gpldi	238	49	I.	i.	NN
cord-302047-vv5gpldi	239	1	To	to	TO
cord-302047-vv5gpldi	239	2	illustrate	illustrate	VB
cord-302047-vv5gpldi	239	3	the	the	DT
cord-302047-vv5gpldi	239	4	effects	effect	NNS
cord-302047-vv5gpldi	239	5	of	of	IN
cord-302047-vv5gpldi	239	6	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	239	7	we	-PRON-	PRP
cord-302047-vv5gpldi	239	8	chose	choose	VBD
cord-302047-vv5gpldi	239	9	the	the	DT
cord-302047-vv5gpldi	239	10	parameters	parameter	NNS
cord-302047-vv5gpldi	239	11	in	in	IN
cord-302047-vv5gpldi	239	12	Table	Table	NNP
cord-302047-vv5gpldi	239	13	2	2	CD
cord-302047-vv5gpldi	239	14	,	,	,
cord-302047-vv5gpldi	239	15	set	set	VBD
cord-302047-vv5gpldi	239	16	the	the	DT
cord-302047-vv5gpldi	239	17	initial	initial	JJ
cord-302047-vv5gpldi	239	18	f	f	NN
cord-302047-vv5gpldi	239	19	D	D	NNP
cord-302047-vv5gpldi	239	20	to	to	IN
cord-302047-vv5gpldi	239	21	zero	zero	CD
cord-302047-vv5gpldi	239	22	,	,	,
cord-302047-vv5gpldi	239	23	and	and	CC
cord-302047-vv5gpldi	239	24	considered	consider	VBD
cord-302047-vv5gpldi	239	25	various	various	JJ
cord-302047-vv5gpldi	239	26	values	value	NNS
cord-302047-vv5gpldi	239	27	of	of	IN
cord-302047-vv5gpldi	239	28	a.	a.	NN
cord-302047-vv5gpldi	240	1	The	the	DT
cord-302047-vv5gpldi	240	2	difference	difference	NN
cord-302047-vv5gpldi	240	3	in	in	IN
cord-302047-vv5gpldi	240	4	fitness	fitness	NN
cord-302047-vv5gpldi	240	5	between	between	IN
cord-302047-vv5gpldi	240	6	the	the	DT
cord-302047-vv5gpldi	240	7	virus	virus	NN
cord-302047-vv5gpldi	240	8	with	with	IN
cord-302047-vv5gpldi	240	9	insertion	insertion	NN
cord-302047-vv5gpldi	240	10	and	and	CC
cord-302047-vv5gpldi	240	11	without	without	IN
cord-302047-vv5gpldi	240	12	is	be	VBZ
cord-302047-vv5gpldi	240	13	large	large	JJ
cord-302047-vv5gpldi	241	1	(	(	-LRB-
cord-302047-vv5gpldi	241	2	x	x	NN
cord-302047-vv5gpldi	241	3	I	i	NN
cord-302047-vv5gpldi	241	4	=	=	NN
cord-302047-vv5gpldi	241	5	x	x	NN
cord-302047-vv5gpldi	241	6	D	D	NNP
cord-302047-vv5gpldi	241	7	¼	¼	NN
cord-302047-vv5gpldi	241	8	0:8	0:8	CD
cord-302047-vv5gpldi	241	9	)	)	-RRB-
cord-302047-vv5gpldi	241	10	.	.	.
cord-302047-vv5gpldi	242	1	The	the	DT
cord-302047-vv5gpldi	242	2	simulation	simulation	NN
cord-302047-vv5gpldi	242	3	data	datum	NNS
cord-302047-vv5gpldi	242	4	illustrate	illustrate	VBP
cord-302047-vv5gpldi	242	5	how	how	WRB
cord-302047-vv5gpldi	242	6	under	under	IN
cord-302047-vv5gpldi	242	7	these	these	DT
cord-302047-vv5gpldi	242	8	conditions	condition	NNS
cord-302047-vv5gpldi	242	9	narrow	narrow	JJ
cord-302047-vv5gpldi	242	10	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	242	11	can	can	MD
cord-302047-vv5gpldi	242	12	lead	lead	VB
cord-302047-vv5gpldi	242	13	to	to	IN
cord-302047-vv5gpldi	242	14	stable	stable	JJ
cord-302047-vv5gpldi	242	15	inserted	insert	VBN
cord-302047-vv5gpldi	242	16	sequence	sequence	NN
cord-302047-vv5gpldi	242	17	(	(	-LRB-
cord-302047-vv5gpldi	242	18	Fig	Fig	NNP
cord-302047-vv5gpldi	242	19	.	.	NNP
cord-302047-vv5gpldi	242	20	2	2	CD
cord-302047-vv5gpldi	242	21	)	)	-RRB-
cord-302047-vv5gpldi	242	22	.	.	.
cord-302047-vv5gpldi	243	1	During	during	IN
cord-302047-vv5gpldi	243	2	each	each	DT
cord-302047-vv5gpldi	243	3	round	round	NN
cord-302047-vv5gpldi	243	4	of	of	IN
cord-302047-vv5gpldi	243	5	passaging	passage	VBG
cord-302047-vv5gpldi	243	6	the	the	DT
cord-302047-vv5gpldi	243	7	frequency	frequency	NN
cord-302047-vv5gpldi	243	8	of	of	IN
cord-302047-vv5gpldi	243	9	the	the	DT
cord-302047-vv5gpldi	243	10	deletion	deletion	NN
cord-302047-vv5gpldi	243	11	variant	variant	NN
cord-302047-vv5gpldi	243	12	comes	come	VBZ
cord-302047-vv5gpldi	243	13	up	up	RP
cord-302047-vv5gpldi	243	14	,	,	,
cord-302047-vv5gpldi	243	15	but	but	CC
cord-302047-vv5gpldi	243	16	as	as	IN
cord-302047-vv5gpldi	243	17	it	-PRON-	PRP
cord-302047-vv5gpldi	243	18	does	do	VBZ
cord-302047-vv5gpldi	243	19	not	not	RB
cord-302047-vv5gpldi	243	20	reach	reach	VB
cord-302047-vv5gpldi	243	21	a	a	DT
cord-302047-vv5gpldi	243	22	frequency	frequency	NN
cord-302047-vv5gpldi	243	23	near	near	IN
cord-302047-vv5gpldi	243	24	1	1	CD
cord-302047-vv5gpldi	243	25	/	/	SYM
cord-302047-vv5gpldi	243	26	a	a	NN
cord-302047-vv5gpldi	243	27	this	this	DT
cord-302047-vv5gpldi	243	28	variant	variant	NN
cord-302047-vv5gpldi	243	29	is	be	VBZ
cord-302047-vv5gpldi	243	30	not	not	RB
cord-302047-vv5gpldi	243	31	sampled	sample	VBN
cord-302047-vv5gpldi	243	32	during	during	IN
cord-302047-vv5gpldi	243	33	the	the	DT
cord-302047-vv5gpldi	243	34	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	243	35	.	.	.
cord-302047-vv5gpldi	244	1	Only	only	RB
cord-302047-vv5gpldi	244	2	when	when	WRB
cord-302047-vv5gpldi	244	3	the	the	DT
cord-302047-vv5gpldi	244	4	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	244	5	is	be	VBZ
cord-302047-vv5gpldi	244	6	wider	wide	JJR
cord-302047-vv5gpldi	244	7	is	be	VBZ
cord-302047-vv5gpldi	244	8	the	the	DT
cord-302047-vv5gpldi	244	9	probability	probability	NN
cord-302047-vv5gpldi	244	10	of	of	IN
cord-302047-vv5gpldi	244	11	sampling	sample	VBG
cord-302047-vv5gpldi	244	12	the	the	DT
cord-302047-vv5gpldi	244	13	virus	virus	NN
cord-302047-vv5gpldi	244	14	variant	variant	NN
cord-302047-vv5gpldi	244	15	with	with	IN
cord-302047-vv5gpldi	244	16	a	a	DT
cord-302047-vv5gpldi	244	17	deletion	deletion	NN
cord-302047-vv5gpldi	244	18	large	large	JJ
cord-302047-vv5gpldi	244	19	enough	enough	RB
cord-302047-vv5gpldi	244	20	for	for	IN
cord-302047-vv5gpldi	244	21	this	this	DT
cord-302047-vv5gpldi	244	22	to	to	TO
cord-302047-vv5gpldi	244	23	occur	occur	VB
cord-302047-vv5gpldi	244	24	regularly	regularly	RB
cord-302047-vv5gpldi	244	25	.	.	.
cord-302047-vv5gpldi	245	1	Once	once	RB
cord-302047-vv5gpldi	245	2	a	a	DT
cord-302047-vv5gpldi	245	3	deletion	deletion	NN
cord-302047-vv5gpldi	245	4	variant	variant	NN
cord-302047-vv5gpldi	245	5	has	have	VBZ
cord-302047-vv5gpldi	245	6	been	be	VBN
cord-302047-vv5gpldi	245	7	sampled	sample	VBN
cord-302047-vv5gpldi	245	8	during	during	IN
cord-302047-vv5gpldi	245	9	the	the	DT
cord-302047-vv5gpldi	245	10	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	245	11	,	,	,
cord-302047-vv5gpldi	245	12	it	-PRON-	PRP
cord-302047-vv5gpldi	245	13	rapidly	rapidly	RB
cord-302047-vv5gpldi	245	14	goes	go	VBZ
cord-302047-vv5gpldi	245	15	to	to	IN
cord-302047-vv5gpldi	245	16	fixation	fixation	NN
cord-302047-vv5gpldi	245	17	as	as	IN
cord-302047-vv5gpldi	245	18	it	-PRON-	PRP
cord-302047-vv5gpldi	245	19	has	have	VBZ
cord-302047-vv5gpldi	245	20	a	a	DT
cord-302047-vv5gpldi	245	21	much	much	RB
cord-302047-vv5gpldi	245	22	higher	high	JJR
cord-302047-vv5gpldi	245	23	fitness	fitness	NN
cord-302047-vv5gpldi	245	24	than	than	IN
cord-302047-vv5gpldi	245	25	the	the	DT
cord-302047-vv5gpldi	245	26	full	full	JJ
cord-302047-vv5gpldi	245	27	-	-	HYPH
cord-302047-vv5gpldi	245	28	length	length	NN
cord-302047-vv5gpldi	245	29	virus	virus	NN
cord-302047-vv5gpldi	245	30	.	.	.
cord-302047-vv5gpldi	246	1	Figure	figure	NN
cord-302047-vv5gpldi	246	2	1	1	CD
cord-302047-vv5gpldi	246	3	provides	provide	VBZ
cord-302047-vv5gpldi	246	4	a	a	DT
cord-302047-vv5gpldi	246	5	simple	simple	JJ
cord-302047-vv5gpldi	246	6	illustration	illustration	NN
cord-302047-vv5gpldi	246	7	of	of	IN
cord-302047-vv5gpldi	246	8	the	the	DT
cord-302047-vv5gpldi	246	9	same	same	JJ
cord-302047-vv5gpldi	246	10	principle	principle	NN
cord-302047-vv5gpldi	246	11	.	.	.
cord-302047-vv5gpldi	247	1	When	when	WRB
cord-302047-vv5gpldi	247	2	considering	consider	VBG
cord-302047-vv5gpldi	247	3	host	host	NN
cord-302047-vv5gpldi	247	4	species	specie	NNS
cord-302047-vv5gpldi	247	5	jumps	jump	VBZ
cord-302047-vv5gpldi	247	6	using	use	VBG
cord-302047-vv5gpldi	247	7	the	the	DT
cord-302047-vv5gpldi	247	8	same	same	JJ
cord-302047-vv5gpldi	247	9	TEV	TEV	NNP
cord-302047-vv5gpldi	247	10	-	-	HYPH
cord-302047-vv5gpldi	247	11	eGFP	eGFP	NNP
cord-302047-vv5gpldi	247	12	vector	vector	NN
cord-302047-vv5gpldi	247	13	,	,	,
cord-302047-vv5gpldi	247	14	we	-PRON-	PRP
cord-302047-vv5gpldi	247	15	show	show	VBP
cord-302047-vv5gpldi	247	16	that	that	IN
cord-302047-vv5gpldi	247	17	host	host	NN
cord-302047-vv5gpldi	247	18	switches	switch	NNS
cord-302047-vv5gpldi	247	19	can	can	MD
cord-302047-vv5gpldi	247	20	radically	radically	RB
cord-302047-vv5gpldi	247	21	change	change	VB
cord-302047-vv5gpldi	247	22	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	247	23	dynamics	dynamic	NNS
cord-302047-vv5gpldi	247	24	(	(	-LRB-
cord-302047-vv5gpldi	247	25	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	247	26	,	,	,
cord-302047-vv5gpldi	247	27	Zwart	Zwart	NNP
cord-302047-vv5gpldi	247	28	,	,	,
cord-302047-vv5gpldi	247	29	and	and	CC
cord-302047-vv5gpldi	247	30	Elena	Elena	NNP
cord-302047-vv5gpldi	247	31	2017	2017	CD
cord-302047-vv5gpldi	247	32	)	)	-RRB-
cord-302047-vv5gpldi	247	33	.	.	.
cord-302047-vv5gpldi	248	1	After	after	IN
cord-302047-vv5gpldi	248	2	over	over	IN
cord-302047-vv5gpldi	248	3	half	half	PDT
cord-302047-vv5gpldi	248	4	a	a	DT
cord-302047-vv5gpldi	248	5	year	year	NN
cord-302047-vv5gpldi	248	6	of	of	IN
cord-302047-vv5gpldi	248	7	evolution	evolution	NN
cord-302047-vv5gpldi	248	8	in	in	IN
cord-302047-vv5gpldi	248	9	two	two	CD
cord-302047-vv5gpldi	248	10	semi	semi	JJ
cord-302047-vv5gpldi	248	11	-	-	JJ
cord-302047-vv5gpldi	248	12	permissive	permissive	JJ
cord-302047-vv5gpldi	248	13	host	host	NN
cord-302047-vv5gpldi	248	14	species	specie	NNS
cord-302047-vv5gpldi	248	15	,	,	,
cord-302047-vv5gpldi	248	16	with	with	IN
cord-302047-vv5gpldi	248	17	a	a	DT
cord-302047-vv5gpldi	248	18	large	large	JJ
cord-302047-vv5gpldi	248	19	difference	difference	NN
cord-302047-vv5gpldi	248	20	in	in	IN
cord-302047-vv5gpldi	248	21	virus	virus	NN
cord-302047-vv5gpldi	248	22	-	-	HYPH
cord-302047-vv5gpldi	248	23	induced	induce	VBN
cord-302047-vv5gpldi	248	24	virulence	virulence	NN
cord-302047-vv5gpldi	248	25	,	,	,
cord-302047-vv5gpldi	248	26	the	the	DT
cord-302047-vv5gpldi	248	27	eGFP	egfp	JJ
cord-302047-vv5gpldi	248	28	insert	insert	NN
cord-302047-vv5gpldi	248	29	appears	appear	VBZ
cord-302047-vv5gpldi	248	30	to	to	TO
cord-302047-vv5gpldi	248	31	remain	remain	VB
cord-302047-vv5gpldi	248	32	stable	stable	JJ
cord-302047-vv5gpldi	248	33	.	.	.
cord-302047-vv5gpldi	249	1	A	a	DT
cord-302047-vv5gpldi	249	2	fitness	fitness	NN
cord-302047-vv5gpldi	249	3	costs	cost	NNS
cord-302047-vv5gpldi	249	4	of	of	IN
cord-302047-vv5gpldi	249	5	eGFP	eGFP	NNP
cord-302047-vv5gpldi	249	6	was	be	VBD
cord-302047-vv5gpldi	249	7	only	only	RB
cord-302047-vv5gpldi	249	8	found	find	VBN
cord-302047-vv5gpldi	249	9	in	in	IN
cord-302047-vv5gpldi	249	10	the	the	DT
cord-302047-vv5gpldi	249	11	host	host	NN
cord-302047-vv5gpldi	249	12	for	for	IN
cord-302047-vv5gpldi	249	13	which	which	WDT
cord-302047-vv5gpldi	249	14	TEV	TEV	NNP
cord-302047-vv5gpldi	249	15	has	have	VBZ
cord-302047-vv5gpldi	249	16	low	low	JJ
cord-302047-vv5gpldi	249	17	virulence	virulence	NN
cord-302047-vv5gpldi	249	18	.	.	.
cord-302047-vv5gpldi	250	1	In	in	IN
cord-302047-vv5gpldi	250	2	the	the	DT
cord-302047-vv5gpldi	250	3	hosts	host	NNS
cord-302047-vv5gpldi	250	4	for	for	IN
cord-302047-vv5gpldi	250	5	which	which	WDT
cord-302047-vv5gpldi	250	6	TEV	TEV	NNP
cord-302047-vv5gpldi	250	7	has	have	VBZ
cord-302047-vv5gpldi	250	8	high	high	JJ
cord-302047-vv5gpldi	250	9	virulence	virulence	NN
cord-302047-vv5gpldi	250	10	there	there	EX
cord-302047-vv5gpldi	250	11	was	be	VBD
cord-302047-vv5gpldi	250	12	no	no	DT
cord-302047-vv5gpldi	250	13	fitness	fitness	NN
cord-302047-vv5gpldi	250	14	cost	cost	NN
cord-302047-vv5gpldi	250	15	and	and	CC
cord-302047-vv5gpldi	250	16	viral	viral	JJ
cord-302047-vv5gpldi	250	17	adaptation	adaptation	NN
cord-302047-vv5gpldi	250	18	was	be	VBD
cord-302047-vv5gpldi	250	19	observed	observe	VBN
cord-302047-vv5gpldi	250	20	.	.	.
cord-302047-vv5gpldi	251	1	This	this	DT
cord-302047-vv5gpldi	251	2	contradicts	contradict	VBZ
cord-302047-vv5gpldi	251	3	theories	theory	NNS
cord-302047-vv5gpldi	251	4	that	that	WDT
cord-302047-vv5gpldi	251	5	suggest	suggest	VBP
cord-302047-vv5gpldi	251	6	that	that	IN
cord-302047-vv5gpldi	251	7	high	high	JJ
cord-302047-vv5gpldi	251	8	virulence	virulence	NN
cord-302047-vv5gpldi	251	9	could	could	MD
cord-302047-vv5gpldi	251	10	hinder	hinder	VB
cord-302047-vv5gpldi	251	11	between	between	IN
cord-302047-vv5gpldi	251	12	-	-	HYPH
cord-302047-vv5gpldi	251	13	host	host	NN
cord-302047-vv5gpldi	251	14	transmission	transmission	NN
cord-302047-vv5gpldi	251	15	.	.	.
cord-302047-vv5gpldi	252	1	When	when	WRB
cord-302047-vv5gpldi	252	2	considering	consider	VBG
cord-302047-vv5gpldi	252	3	the	the	DT
cord-302047-vv5gpldi	252	4	evolution	evolution	NN
cord-302047-vv5gpldi	252	5	of	of	IN
cord-302047-vv5gpldi	252	6	genome	genome	NN
cord-302047-vv5gpldi	252	7	architecture	architecture	NN
cord-302047-vv5gpldi	252	8	,	,	,
cord-302047-vv5gpldi	252	9	host	host	NN
cord-302047-vv5gpldi	252	10	species	species	NN
cord-302047-vv5gpldi	252	11	jumps	jump	VBZ
cord-302047-vv5gpldi	252	12	might	may	MD
cord-302047-vv5gpldi	252	13	play	play	VB
cord-302047-vv5gpldi	252	14	a	a	DT
cord-302047-vv5gpldi	252	15	very	very	RB
cord-302047-vv5gpldi	252	16	important	important	JJ
cord-302047-vv5gpldi	252	17	role	role	NN
cord-302047-vv5gpldi	252	18	,	,	,
cord-302047-vv5gpldi	252	19	by	by	IN
cord-302047-vv5gpldi	252	20	allowing	allow	VBG
cord-302047-vv5gpldi	252	21	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	252	22	intermediates	intermediate	NNS
cord-302047-vv5gpldi	252	23	to	to	TO
cord-302047-vv5gpldi	252	24	be	be	VB
cord-302047-vv5gpldi	252	25	competitive	competitive	JJ
cord-302047-vv5gpldi	252	26	.	.	.
cord-302047-vv5gpldi	253	1	The	the	DT
cord-302047-vv5gpldi	253	2	stability	stability	NN
cord-302047-vv5gpldi	253	3	of	of	IN
cord-302047-vv5gpldi	253	4	an	an	DT
cord-302047-vv5gpldi	253	5	insert	insert	NN
cord-302047-vv5gpldi	253	6	could	could	MD
cord-302047-vv5gpldi	253	7	change	change	VB
cord-302047-vv5gpldi	253	8	when	when	WRB
cord-302047-vv5gpldi	253	9	considering	consider	VBG
cord-302047-vv5gpldi	253	10	insertions	insertion	NNS
cord-302047-vv5gpldi	253	11	that	that	WDT
cord-302047-vv5gpldi	253	12	might	may	MD
cord-302047-vv5gpldi	253	13	be	be	VB
cord-302047-vv5gpldi	253	14	beneficial	beneficial	JJ
cord-302047-vv5gpldi	253	15	for	for	IN
cord-302047-vv5gpldi	253	16	the	the	DT
cord-302047-vv5gpldi	253	17	virus	virus	NN
cord-302047-vv5gpldi	253	18	.	.	.
cord-302047-vv5gpldi	254	1	Using	use	VBG
cord-302047-vv5gpldi	254	2	the	the	DT
cord-302047-vv5gpldi	254	3	TEV	TEV	NNP
cord-302047-vv5gpldi	254	4	genome	genome	NN
cord-302047-vv5gpldi	254	5	we	-PRON-	PRP
cord-302047-vv5gpldi	254	6	simulated	simulate	VBD
cord-302047-vv5gpldi	254	7	two	two	CD
cord-302047-vv5gpldi	254	8	HGT	HGT	NNP
cord-302047-vv5gpldi	254	9	events	event	NNS
cord-302047-vv5gpldi	254	10	,	,	,
cord-302047-vv5gpldi	254	11	by	by	IN
cord-302047-vv5gpldi	254	12	separately	separately	RB
cord-302047-vv5gpldi	254	13	introducing	introduce	VBG
cord-302047-vv5gpldi	254	14	functional	functional	JJ
cord-302047-vv5gpldi	254	15	exogenous	exogenous	JJ
cord-302047-vv5gpldi	254	16	sequences	sequence	NNS
cord-302047-vv5gpldi	254	17	that	that	WDT
cord-302047-vv5gpldi	254	18	are	be	VBP
cord-302047-vv5gpldi	254	19	potentially	potentially	RB
cord-302047-vv5gpldi	254	20	beneficial	beneficial	JJ
cord-302047-vv5gpldi	254	21	for	for	IN
cord-302047-vv5gpldi	254	22	the	the	DT
cord-302047-vv5gpldi	254	23	virus	virus	NN
cord-302047-vv5gpldi	254	24	(	(	-LRB-
cord-302047-vv5gpldi	254	25	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	254	26	et	et	NNP
cord-302047-vv5gpldi	254	27	al	al	NNP
cord-302047-vv5gpldi	254	28	.	.	.
cord-302047-vv5gpldi	254	29	2017	2017	CD
cord-302047-vv5gpldi	254	30	)	)	-RRB-
cord-302047-vv5gpldi	254	31	.	.	.
cord-302047-vv5gpldi	255	1	In	in	IN
cord-302047-vv5gpldi	255	2	one	one	CD
cord-302047-vv5gpldi	255	3	case	case	NN
cord-302047-vv5gpldi	255	4	,	,	,
cord-302047-vv5gpldi	255	5	the	the	DT
cord-302047-vv5gpldi	255	6	insertion	insertion	NN
cord-302047-vv5gpldi	255	7	was	be	VBD
cord-302047-vv5gpldi	255	8	rapidly	rapidly	RB
cord-302047-vv5gpldi	255	9	purged	purge	VBN
cord-302047-vv5gpldi	255	10	from	from	IN
cord-302047-vv5gpldi	255	11	the	the	DT
cord-302047-vv5gpldi	255	12	viral	viral	JJ
cord-302047-vv5gpldi	255	13	genome	genome	NN
cord-302047-vv5gpldi	255	14	,	,	,
cord-302047-vv5gpldi	255	15	restoring	restore	VBG
cord-302047-vv5gpldi	255	16	fitness	fitness	NN
cord-302047-vv5gpldi	255	17	to	to	IN
cord-302047-vv5gpldi	255	18	wild	wild	JJ
cord-302047-vv5gpldi	255	19	-	-	HYPH
cord-302047-vv5gpldi	255	20	type	type	NN
cord-302047-vv5gpldi	255	21	fitness	fitness	NN
cord-302047-vv5gpldi	255	22	levels	level	NNS
cord-302047-vv5gpldi	255	23	.	.	.
cord-302047-vv5gpldi	256	1	In	in	IN
cord-302047-vv5gpldi	256	2	another	another	DT
cord-302047-vv5gpldi	256	3	case	case	NN
cord-302047-vv5gpldi	256	4	,	,	,
cord-302047-vv5gpldi	256	5	the	the	DT
cord-302047-vv5gpldi	256	6	inserted	insert	VBN
cord-302047-vv5gpldi	256	7	gene	gene	NN
cord-302047-vv5gpldi	256	8	-	-	:
cord-302047-vv5gpldi	256	9	the	the	DT
cord-302047-vv5gpldi	256	10	2b	2b	NNP
cord-302047-vv5gpldi	256	11	RNA	RNA	NNP
cord-302047-vv5gpldi	256	12	silencing	silence	VBG
cord-302047-vv5gpldi	256	13	suppressor	suppressor	NN
cord-302047-vv5gpldi	256	14	from	from	IN
cord-302047-vv5gpldi	256	15	Cucumber	Cucumber	NNP
cord-302047-vv5gpldi	256	16	mosaic	mosaic	JJ
cord-302047-vv5gpldi	256	17	virus	virus	NN
cord-302047-vv5gpldi	256	18	-	-	:
cord-302047-vv5gpldi	256	19	did	do	VBD
cord-302047-vv5gpldi	256	20	not	not	RB
cord-302047-vv5gpldi	256	21	seem	seem	VB
cord-302047-vv5gpldi	256	22	to	to	TO
cord-302047-vv5gpldi	256	23	have	have	VB
cord-302047-vv5gpldi	256	24	a	a	DT
cord-302047-vv5gpldi	256	25	major	major	JJ
cord-302047-vv5gpldi	256	26	impact	impact	NN
cord-302047-vv5gpldi	256	27	on	on	IN
cord-302047-vv5gpldi	256	28	viral	viral	JJ
cord-302047-vv5gpldi	256	29	fitness	fitness	NN
cord-302047-vv5gpldi	256	30	and	and	CC
cord-302047-vv5gpldi	256	31	was	be	VBD
cord-302047-vv5gpldi	256	32	therefore	therefore	RB
cord-302047-vv5gpldi	256	33	not	not	RB
cord-302047-vv5gpldi	256	34	lost	lose	VBN
cord-302047-vv5gpldi	256	35	when	when	WRB
cord-302047-vv5gpldi	256	36	performing	perform	VBG
cord-302047-vv5gpldi	256	37	experimental	experimental	JJ
cord-302047-vv5gpldi	256	38	evolution	evolution	NN
cord-302047-vv5gpldi	256	39	.	.	.
cord-302047-vv5gpldi	257	1	Interestingly	interestingly	RB
cord-302047-vv5gpldi	257	2	this	this	DT
cord-302047-vv5gpldi	257	3	insertion	insertion	NN
cord-302047-vv5gpldi	257	4	duplicated	duplicate	VBD
cord-302047-vv5gpldi	257	5	the	the	DT
cord-302047-vv5gpldi	257	6	function	function	NN
cord-302047-vv5gpldi	257	7	of	of	IN
cord-302047-vv5gpldi	257	8	RNA	RNA	NNP
cord-302047-vv5gpldi	257	9	silencing	silence	VBG
cord-302047-vv5gpldi	257	10	suppression	suppression	NN
cord-302047-vv5gpldi	257	11	function	function	NN
cord-302047-vv5gpldi	257	12	of	of	IN
cord-302047-vv5gpldi	257	13	another	another	DT
cord-302047-vv5gpldi	257	14	gene	gene	NN
cord-302047-vv5gpldi	257	15	in	in	IN
cord-302047-vv5gpldi	257	16	the	the	DT
cord-302047-vv5gpldi	257	17	genome	genome	NN
cord-302047-vv5gpldi	257	18	.	.	.
cord-302047-vv5gpldi	258	1	When	when	WRB
cord-302047-vv5gpldi	258	2	mutating	mutate	VBG
cord-302047-vv5gpldi	258	3	this	this	DT
cord-302047-vv5gpldi	258	4	functional	functional	JJ
cord-302047-vv5gpldi	258	5	domain	domain	NN
cord-302047-vv5gpldi	258	6	of	of	IN
cord-302047-vv5gpldi	258	7	the	the	DT
cord-302047-vv5gpldi	258	8	TEV	TEV	NNP
cord-302047-vv5gpldi	258	9	gene	gene	NN
cord-302047-vv5gpldi	258	10	,	,	,
cord-302047-vv5gpldi	258	11	the	the	DT
cord-302047-vv5gpldi	258	12	inserted	insert	VBN
cord-302047-vv5gpldi	258	13	gene	gene	NN
cord-302047-vv5gpldi	258	14	provided	provide	VBD
cord-302047-vv5gpldi	258	15	a	a	DT
cord-302047-vv5gpldi	258	16	replicative	replicative	JJ
cord-302047-vv5gpldi	258	17	advantage	advantage	NN
cord-302047-vv5gpldi	258	18	.	.	.
cord-302047-vv5gpldi	259	1	These	these	DT
cord-302047-vv5gpldi	259	2	observations	observation	NNS
cord-302047-vv5gpldi	259	3	suggest	suggest	VBP
cord-302047-vv5gpldi	259	4	a	a	DT
cord-302047-vv5gpldi	259	5	potentially	potentially	RB
cord-302047-vv5gpldi	259	6	interesting	interesting	JJ
cord-302047-vv5gpldi	259	7	role	role	NN
cord-302047-vv5gpldi	259	8	for	for	IN
cord-302047-vv5gpldi	259	9	HGT	HGT	NNP
cord-302047-vv5gpldi	259	10	of	of	IN
cord-302047-vv5gpldi	259	11	short	short	JJ
cord-302047-vv5gpldi	259	12	functional	functional	JJ
cord-302047-vv5gpldi	259	13	sequences	sequence	NNS
cord-302047-vv5gpldi	259	14	in	in	IN
cord-302047-vv5gpldi	259	15	improving	improve	VBG
cord-302047-vv5gpldi	259	16	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	259	17	constraints	constraint	NNS
cord-302047-vv5gpldi	259	18	on	on	IN
cord-302047-vv5gpldi	259	19	viruses	virus	NNS
cord-302047-vv5gpldi	259	20	.	.	.
cord-302047-vv5gpldi	260	1	Besides	besides	IN
cord-302047-vv5gpldi	260	2	HGT	HGT	NNP
cord-302047-vv5gpldi	260	3	,	,	,
cord-302047-vv5gpldi	260	4	another	another	DT
cord-302047-vv5gpldi	260	5	mechanism	mechanism	NN
cord-302047-vv5gpldi	260	6	for	for	IN
cord-302047-vv5gpldi	260	7	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	260	8	innovation	innovation	NN
cord-302047-vv5gpldi	260	9	is	be	VBZ
cord-302047-vv5gpldi	260	10	gene	gene	NN
cord-302047-vv5gpldi	260	11	duplication	duplication	NN
cord-302047-vv5gpldi	260	12	.	.	.
cord-302047-vv5gpldi	261	1	The	the	DT
cord-302047-vv5gpldi	261	2	effects	effect	NNS
cord-302047-vv5gpldi	261	3	in	in	IN
cord-302047-vv5gpldi	261	4	the	the	DT
cord-302047-vv5gpldi	261	5	stability	stability	NN
cord-302047-vv5gpldi	261	6	on	on	IN
cord-302047-vv5gpldi	261	7	a	a	DT
cord-302047-vv5gpldi	261	8	genetically	genetically	RB
cord-302047-vv5gpldi	261	9	redundant	redundant	JJ
cord-302047-vv5gpldi	261	10	insert	insert	NN
cord-302047-vv5gpldi	261	11	might	may	MD
cord-302047-vv5gpldi	261	12	be	be	VB
cord-302047-vv5gpldi	261	13	variable	variable	JJ
cord-302047-vv5gpldi	261	14	.	.	.
cord-302047-vv5gpldi	262	1	On	on	IN
cord-302047-vv5gpldi	262	2	one	one	CD
cord-302047-vv5gpldi	262	3	hand	hand	NN
cord-302047-vv5gpldi	262	4	,	,	,
cord-302047-vv5gpldi	262	5	one	one	PRP
cord-302047-vv5gpldi	262	6	would	would	MD
cord-302047-vv5gpldi	262	7	expect	expect	VB
cord-302047-vv5gpldi	262	8	the	the	DT
cord-302047-vv5gpldi	262	9	duplicated	duplicate	VBN
cord-302047-vv5gpldi	262	10	copy	copy	NN
cord-302047-vv5gpldi	262	11	to	to	TO
cord-302047-vv5gpldi	262	12	be	be	VB
cord-302047-vv5gpldi	262	13	rapidly	rapidly	RB
cord-302047-vv5gpldi	262	14	deleted	delete	VBN
cord-302047-vv5gpldi	262	15	from	from	IN
cord-302047-vv5gpldi	262	16	the	the	DT
cord-302047-vv5gpldi	262	17	genome	genome	NN
cord-302047-vv5gpldi	262	18	as	as	IN
cord-302047-vv5gpldi	262	19	it	-PRON-	PRP
cord-302047-vv5gpldi	262	20	does	do	VBZ
cord-302047-vv5gpldi	262	21	not	not	RB
cord-302047-vv5gpldi	262	22	confer	confer	VB
cord-302047-vv5gpldi	262	23	an	an	DT
cord-302047-vv5gpldi	262	24	additional	additional	JJ
cord-302047-vv5gpldi	262	25	function	function	NN
cord-302047-vv5gpldi	262	26	.	.	.
cord-302047-vv5gpldi	263	1	On	on	IN
cord-302047-vv5gpldi	263	2	the	the	DT
cord-302047-vv5gpldi	263	3	other	other	JJ
cord-302047-vv5gpldi	263	4	hand	hand	NN
cord-302047-vv5gpldi	263	5	,	,	,
cord-302047-vv5gpldi	263	6	if	if	IN
cord-302047-vv5gpldi	263	7	a	a	DT
cord-302047-vv5gpldi	263	8	duplicated	duplicate	VBN
cord-302047-vv5gpldi	263	9	sequence	sequence	NN
cord-302047-vv5gpldi	263	10	is	be	VBZ
cord-302047-vv5gpldi	263	11	stable	stable	JJ
cord-302047-vv5gpldi	263	12	it	-PRON-	PRP
cord-302047-vv5gpldi	263	13	may	may	MD
cord-302047-vv5gpldi	263	14	act	act	VB
cord-302047-vv5gpldi	263	15	as	as	IN
cord-302047-vv5gpldi	263	16	a	a	DT
cord-302047-vv5gpldi	263	17	stepping	step	VBG
cord-302047-vv5gpldi	263	18	stone	stone	NN
cord-302047-vv5gpldi	263	19	to	to	IN
cord-302047-vv5gpldi	263	20	the	the	DT
cord-302047-vv5gpldi	263	21	evolution	evolution	NN
cord-302047-vv5gpldi	263	22	of	of	IN
cord-302047-vv5gpldi	263	23	new	new	JJ
cord-302047-vv5gpldi	263	24	biological	biological	JJ
cord-302047-vv5gpldi	263	25	functions	function	NNS
cord-302047-vv5gpldi	263	26	.	.	.
cord-302047-vv5gpldi	264	1	We	-PRON-	PRP
cord-302047-vv5gpldi	264	2	have	have	VBP
cord-302047-vv5gpldi	264	3	investigated	investigate	VBN
cord-302047-vv5gpldi	264	4	the	the	DT
cord-302047-vv5gpldi	264	5	stability	stability	NN
cord-302047-vv5gpldi	264	6	of	of	IN
cord-302047-vv5gpldi	264	7	genetically	genetically	RB
cord-302047-vv5gpldi	264	8	redundant	redundant	JJ
cord-302047-vv5gpldi	264	9	sequences	sequence	NNS
cord-302047-vv5gpldi	264	10	by	by	IN
cord-302047-vv5gpldi	264	11	generating	generate	VBG
cord-302047-vv5gpldi	264	12	(	(	-LRB-
cord-302047-vv5gpldi	264	13	TEV	TEV	NNP
cord-302047-vv5gpldi	264	14	)	)	-RRB-
cord-302047-vv5gpldi	264	15	viruses	virus	NNS
cord-302047-vv5gpldi	264	16	with	with	IN
cord-302047-vv5gpldi	264	17	potentially	potentially	RB
cord-302047-vv5gpldi	264	18	beneficial	beneficial	JJ
cord-302047-vv5gpldi	264	19	gene	gene	NN
cord-302047-vv5gpldi	264	20	duplications	duplication	NNS
cord-302047-vv5gpldi	264	21	(	(	-LRB-
cord-302047-vv5gpldi	264	22	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	264	23	et	et	NNP
cord-302047-vv5gpldi	264	24	al	al	NNP
cord-302047-vv5gpldi	264	25	.	.	.
cord-302047-vv5gpldi	264	26	2016	2016	CD
cord-302047-vv5gpldi	264	27	)	)	-RRB-
cord-302047-vv5gpldi	264	28	.	.	.
cord-302047-vv5gpldi	265	1	All	all	DT
cord-302047-vv5gpldi	265	2	gene	gene	NN
cord-302047-vv5gpldi	265	3	duplications	duplication	NNS
cord-302047-vv5gpldi	265	4	resulted	result	VBD
cord-302047-vv5gpldi	265	5	in	in	IN
cord-302047-vv5gpldi	265	6	a	a	DT
cord-302047-vv5gpldi	265	7	loss	loss	NN
cord-302047-vv5gpldi	265	8	of	of	IN
cord-302047-vv5gpldi	265	9	viability	viability	NN
cord-302047-vv5gpldi	265	10	or	or	CC
cord-302047-vv5gpldi	265	11	in	in	IN
cord-302047-vv5gpldi	265	12	a	a	DT
cord-302047-vv5gpldi	265	13	significant	significant	JJ
cord-302047-vv5gpldi	265	14	reduction	reduction	NN
cord-302047-vv5gpldi	265	15	in	in	IN
cord-302047-vv5gpldi	265	16	viral	viral	JJ
cord-302047-vv5gpldi	265	17	fitness	fitness	NN
cord-302047-vv5gpldi	265	18	.	.	.
cord-302047-vv5gpldi	266	1	Experimental	experimental	JJ
cord-302047-vv5gpldi	266	2	evolution	evolution	NN
cord-302047-vv5gpldi	266	3	always	always	RB
cord-302047-vv5gpldi	266	4	led	lead	VBD
cord-302047-vv5gpldi	266	5	to	to	IN
cord-302047-vv5gpldi	266	6	deletion	deletion	NN
cord-302047-vv5gpldi	266	7	of	of	IN
cord-302047-vv5gpldi	266	8	the	the	DT
cord-302047-vv5gpldi	266	9	duplicated	duplicate	VBN
cord-302047-vv5gpldi	266	10	gene	gene	NN
cord-302047-vv5gpldi	266	11	copy	copy	NN
cord-302047-vv5gpldi	266	12	and	and	CC
cord-302047-vv5gpldi	266	13	maintenance	maintenance	NN
cord-302047-vv5gpldi	266	14	of	of	IN
cord-302047-vv5gpldi	266	15	the	the	DT
cord-302047-vv5gpldi	266	16	ancestral	ancestral	JJ
cord-302047-vv5gpldi	266	17	copy	copy	NN
cord-302047-vv5gpldi	266	18	.	.	.
cord-302047-vv5gpldi	267	1	However	however	RB
cord-302047-vv5gpldi	267	2	,	,	,
cord-302047-vv5gpldi	267	3	the	the	DT
cord-302047-vv5gpldi	267	4	stability	stability	NN
cord-302047-vv5gpldi	267	5	of	of	IN
cord-302047-vv5gpldi	267	6	the	the	DT
cord-302047-vv5gpldi	267	7	different	different	JJ
cord-302047-vv5gpldi	267	8	duplicated	duplicate	VBN
cord-302047-vv5gpldi	267	9	genes	gene	NNS
cord-302047-vv5gpldi	267	10	was	be	VBD
cord-302047-vv5gpldi	267	11	highly	highly	RB
cord-302047-vv5gpldi	267	12	divergent	divergent	JJ
cord-302047-vv5gpldi	267	13	,	,	,
cord-302047-vv5gpldi	267	14	suggesting	suggest	VBG
cord-302047-vv5gpldi	267	15	that	that	DT
cord-302047-vv5gpldi	267	16	passage	passage	NN
cord-302047-vv5gpldi	267	17	duration	duration	NN
cord-302047-vv5gpldi	267	18	is	be	VBZ
cord-302047-vv5gpldi	267	19	not	not	RB
cord-302047-vv5gpldi	267	20	the	the	DT
cord-302047-vv5gpldi	267	21	main	main	JJ
cord-302047-vv5gpldi	267	22	factor	factor	NN
cord-302047-vv5gpldi	267	23	for	for	IN
cord-302047-vv5gpldi	267	24	determining	determine	VBG
cord-302047-vv5gpldi	267	25	whether	whether	IN
cord-302047-vv5gpldi	267	26	the	the	DT
cord-302047-vv5gpldi	267	27	insert	insert	NN
cord-302047-vv5gpldi	267	28	will	will	MD
cord-302047-vv5gpldi	267	29	be	be	VB
cord-302047-vv5gpldi	267	30	stable	stable	JJ
cord-302047-vv5gpldi	267	31	or	or	CC
cord-302047-vv5gpldi	267	32	unstable	unstable	JJ
cord-302047-vv5gpldi	267	33	.	.	.
cord-302047-vv5gpldi	268	1	The	the	DT
cord-302047-vv5gpldi	268	2	deletion	deletion	NN
cord-302047-vv5gpldi	268	3	dynamics	dynamic	NNS
cord-302047-vv5gpldi	268	4	of	of	IN
cord-302047-vv5gpldi	268	5	the	the	DT
cord-302047-vv5gpldi	268	6	duplicated	duplicate	VBN
cord-302047-vv5gpldi	268	7	genes	gene	NNS
cord-302047-vv5gpldi	268	8	were	be	VBD
cord-302047-vv5gpldi	268	9	associated	associate	VBN
cord-302047-vv5gpldi	268	10	with	with	IN
cord-302047-vv5gpldi	268	11	the	the	DT
cord-302047-vv5gpldi	268	12	passage	passage	NN
cord-302047-vv5gpldi	268	13	duration	duration	NN
cord-302047-vv5gpldi	268	14	and	and	CC
cord-302047-vv5gpldi	268	15	the	the	DT
cord-302047-vv5gpldi	268	16	size	size	NN
cord-302047-vv5gpldi	268	17	of	of	IN
cord-302047-vv5gpldi	268	18	the	the	DT
cord-302047-vv5gpldi	268	19	duplicated	duplicate	VBN
cord-302047-vv5gpldi	268	20	copy	copy	NN
cord-302047-vv5gpldi	268	21	.	.	.
cord-302047-vv5gpldi	269	1	By	by	IN
cord-302047-vv5gpldi	269	2	developing	develop	VBG
cord-302047-vv5gpldi	269	3	a	a	DT
cord-302047-vv5gpldi	269	4	mathematical	mathematical	JJ
cord-302047-vv5gpldi	269	5	model	model	NN
cord-302047-vv5gpldi	269	6	we	-PRON-	PRP
cord-302047-vv5gpldi	269	7	showed	show	VBD
cord-302047-vv5gpldi	269	8	that	that	IN
cord-302047-vv5gpldi	269	9	the	the	DT
cord-302047-vv5gpldi	269	10	fitness	fitness	NN
cord-302047-vv5gpldi	269	11	effects	effect	NNS
cord-302047-vv5gpldi	269	12	alone	alone	RB
cord-302047-vv5gpldi	269	13	are	be	VBP
cord-302047-vv5gpldi	269	14	not	not	RB
cord-302047-vv5gpldi	269	15	enough	enough	JJ
cord-302047-vv5gpldi	269	16	to	to	TO
cord-302047-vv5gpldi	269	17	predict	predict	VB
cord-302047-vv5gpldi	269	18	genomic	genomic	JJ
cord-302047-vv5gpldi	269	19	stability	stability	NN
cord-302047-vv5gpldi	269	20	.	.	.
cord-302047-vv5gpldi	270	1	A	a	DT
cord-302047-vv5gpldi	270	2	context	context	NN
cord-302047-vv5gpldi	270	3	-	-	HYPH
cord-302047-vv5gpldi	270	4	dependent	dependent	JJ
cord-302047-vv5gpldi	270	5	recombination	recombination	NN
cord-302047-vv5gpldi	270	6	rate	rate	NN
cord-302047-vv5gpldi	270	7	is	be	VBZ
cord-302047-vv5gpldi	270	8	also	also	RB
cord-302047-vv5gpldi	270	9	required	require	VBN
cord-302047-vv5gpldi	270	10	,	,	,
cord-302047-vv5gpldi	270	11	with	with	IN
cord-302047-vv5gpldi	270	12	the	the	DT
cord-302047-vv5gpldi	270	13	context	context	NN
cord-302047-vv5gpldi	270	14	being	be	VBG
cord-302047-vv5gpldi	270	15	the	the	DT
cord-302047-vv5gpldi	270	16	identity	identity	NN
cord-302047-vv5gpldi	270	17	of	of	IN
cord-302047-vv5gpldi	270	18	the	the	DT
cord-302047-vv5gpldi	270	19	insert	insert	NN
cord-302047-vv5gpldi	270	20	and	and	CC
cord-302047-vv5gpldi	270	21	its	-PRON-	PRP$
cord-302047-vv5gpldi	270	22	position	position	NN
cord-302047-vv5gpldi	270	23	.	.	.
cord-302047-vv5gpldi	271	1	In	in	IN
cord-302047-vv5gpldi	271	2	summary	summary	NN
cord-302047-vv5gpldi	271	3	,	,	,
cord-302047-vv5gpldi	271	4	these	these	DT
cord-302047-vv5gpldi	271	5	experimental	experimental	JJ
cord-302047-vv5gpldi	271	6	observations	observation	NNS
cord-302047-vv5gpldi	271	7	demonstrate	demonstrate	VBP
cord-302047-vv5gpldi	271	8	the	the	DT
cord-302047-vv5gpldi	271	9	deleterious	deleterious	JJ
cord-302047-vv5gpldi	271	10	nature	nature	NN
cord-302047-vv5gpldi	271	11	of	of	IN
cord-302047-vv5gpldi	271	12	gene	gene	NN
cord-302047-vv5gpldi	271	13	insertions	insertion	NNS
cord-302047-vv5gpldi	271	14	in	in	IN
cord-302047-vv5gpldi	271	15	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	271	16	)	)	-RRB-
cord-302047-vv5gpldi	271	17	viruses	virus	NNS
cord-302047-vv5gpldi	271	18	,	,	,
cord-302047-vv5gpldi	271	19	where	where	WRB
cord-302047-vv5gpldi	271	20	the	the	DT
cord-302047-vv5gpldi	271	21	highly	highly	RB
cord-302047-vv5gpldi	271	22	streamlined	streamline	VBN
cord-302047-vv5gpldi	271	23	genomes	genome	NNS
cord-302047-vv5gpldi	271	24	limit	limit	VBP
cord-302047-vv5gpldi	271	25	sequence	sequence	NN
cord-302047-vv5gpldi	271	26	space	space	NN
cord-302047-vv5gpldi	271	27	for	for	IN
cord-302047-vv5gpldi	271	28	the	the	DT
cord-302047-vv5gpldi	271	29	evolution	evolution	NN
cord-302047-vv5gpldi	271	30	of	of	IN
cord-302047-vv5gpldi	271	31	novel	novel	NN
cord-302047-vv5gpldi	271	32	functions	function	NNS
cord-302047-vv5gpldi	271	33	,	,	,
cord-302047-vv5gpldi	271	34	and	and	CC
cord-302047-vv5gpldi	271	35	in	in	IN
cord-302047-vv5gpldi	271	36	turn	turn	NN
cord-302047-vv5gpldi	271	37	adaptation	adaptation	NN
cord-302047-vv5gpldi	271	38	to	to	IN
cord-302047-vv5gpldi	271	39	environmental	environmental	JJ
cord-302047-vv5gpldi	271	40	changes	change	NNS
cord-302047-vv5gpldi	271	41	.	.	.
cord-302047-vv5gpldi	272	1	The	the	DT
cord-302047-vv5gpldi	272	2	ssRNA(À	ssRNA(À	NNS
cord-302047-vv5gpldi	272	3	)	)	-RRB-
cord-302047-vv5gpldi	272	4	viruses	virus	NNS
cord-302047-vv5gpldi	272	5	are	be	VBP
cord-302047-vv5gpldi	272	6	composed	compose	VBN
cord-302047-vv5gpldi	272	7	of	of	IN
cord-302047-vv5gpldi	272	8	genomes	genome	NNS
cord-302047-vv5gpldi	272	9	that	that	WDT
cord-302047-vv5gpldi	272	10	range	range	VBP
cord-302047-vv5gpldi	272	11	from	from	IN
cord-302047-vv5gpldi	272	12	10	10	CD
cord-302047-vv5gpldi	272	13	to	to	IN
cord-302047-vv5gpldi	272	14	25.2	25.2	CD
cord-302047-vv5gpldi	272	15	kbp	kbp	NNS
cord-302047-vv5gpldi	272	16	in	in	IN
cord-302047-vv5gpldi	272	17	size	size	NN
cord-302047-vv5gpldi	272	18	.	.	.
cord-302047-vv5gpldi	273	1	These	these	DT
cord-302047-vv5gpldi	273	2	viruses	virus	NNS
cord-302047-vv5gpldi	273	3	are	be	VBP
cord-302047-vv5gpldi	273	4	particularly	particularly	RB
cord-302047-vv5gpldi	273	5	attractive	attractive	JJ
cord-302047-vv5gpldi	273	6	candidates	candidate	NNS
cord-302047-vv5gpldi	273	7	as	as	IN
cord-302047-vv5gpldi	273	8	viral	viral	JJ
cord-302047-vv5gpldi	273	9	vectors	vector	NNS
cord-302047-vv5gpldi	273	10	.	.	.
cord-302047-vv5gpldi	274	1	While	while	IN
cord-302047-vv5gpldi	274	2	in	in	IN
cord-302047-vv5gpldi	274	3	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	274	4	)	)	-RRB-
cord-302047-vv5gpldi	274	5	viruses	viruse	VBZ
cord-302047-vv5gpldi	274	6	inserts	insert	NNS
cord-302047-vv5gpldi	274	7	are	be	VBP
cord-302047-vv5gpldi	274	8	subject	subject	JJ
cord-302047-vv5gpldi	274	9	to	to	IN
cord-302047-vv5gpldi	274	10	deletion	deletion	NN
cord-302047-vv5gpldi	274	11	,	,	,
cord-302047-vv5gpldi	274	12	inserts	insert	NNS
cord-302047-vv5gpldi	274	13	in	in	IN
cord-302047-vv5gpldi	274	14	their	-PRON-	PRP$
cord-302047-vv5gpldi	274	15	ssRNA(À	ssRNA(À	NNS
cord-302047-vv5gpldi	274	16	)	)	-RRB-
cord-302047-vv5gpldi	274	17	counterparts	counterpart	NNS
cord-302047-vv5gpldi	274	18	appear	appear	VBP
cord-302047-vv5gpldi	274	19	more	more	RBR
cord-302047-vv5gpldi	274	20	stable	stable	JJ
cord-302047-vv5gpldi	274	21	(	(	-LRB-
cord-302047-vv5gpldi	274	22	Mebatsion	Mebatsion	NNP
cord-302047-vv5gpldi	274	23	et	et	NNP
cord-302047-vv5gpldi	274	24	al.1996	al.1996	NN
cord-302047-vv5gpldi	274	25	;	;	:
cord-302047-vv5gpldi	275	1	Schnell	Schnell	NNP
cord-302047-vv5gpldi	275	2	et	et	NNP
cord-302047-vv5gpldi	275	3	al	al	NNP
cord-302047-vv5gpldi	275	4	.	.	.
cord-302047-vv5gpldi	275	5	1996	1996	CD
cord-302047-vv5gpldi	275	6	)	)	-RRB-
cord-302047-vv5gpldi	275	7	.	.	.
cord-302047-vv5gpldi	276	1	One	one	CD
cord-302047-vv5gpldi	276	2	reason	reason	NN
cord-302047-vv5gpldi	276	3	for	for	IN
cord-302047-vv5gpldi	276	4	this	this	DT
cord-302047-vv5gpldi	276	5	stability	stability	NN
cord-302047-vv5gpldi	276	6	is	be	VBZ
cord-302047-vv5gpldi	276	7	that	that	IN
cord-302047-vv5gpldi	276	8	in	in	IN
cord-302047-vv5gpldi	276	9	general	general	JJ
cord-302047-vv5gpldi	276	10	the	the	DT
cord-302047-vv5gpldi	276	11	genes	gene	NNS
cord-302047-vv5gpldi	276	12	in	in	IN
cord-302047-vv5gpldi	276	13	the	the	DT
cord-302047-vv5gpldi	276	14	ssRNA(À	ssRNA(À	NNS
cord-302047-vv5gpldi	276	15	)	)	-RRB-
cord-302047-vv5gpldi	276	16	viral	viral	JJ
cord-302047-vv5gpldi	276	17	genomes	genome	NNS
cord-302047-vv5gpldi	276	18	are	be	VBP
cord-302047-vv5gpldi	276	19	non	non	JJ
cord-302047-vv5gpldi	276	20	-	-	JJ
cord-302047-vv5gpldi	276	21	overlapping	overlapping	JJ
cord-302047-vv5gpldi	276	22	and	and	CC
cord-302047-vv5gpldi	276	23	are	be	VBP
cord-302047-vv5gpldi	276	24	expressed	express	VBN
cord-302047-vv5gpldi	276	25	as	as	IN
cord-302047-vv5gpldi	276	26	separate	separate	JJ
cord-302047-vv5gpldi	276	27	mRNAs	mrna	NNS
cord-302047-vv5gpldi	276	28	,	,	,
cord-302047-vv5gpldi	276	29	thus	thus	RB
cord-302047-vv5gpldi	276	30	consisting	consist	VBG
cord-302047-vv5gpldi	276	31	of	of	IN
cord-302047-vv5gpldi	276	32	a	a	DT
cord-302047-vv5gpldi	276	33	modular	modular	JJ
cord-302047-vv5gpldi	276	34	organization	organization	NN
cord-302047-vv5gpldi	276	35	that	that	WDT
cord-302047-vv5gpldi	276	36	can	can	MD
cord-302047-vv5gpldi	276	37	be	be	VB
cord-302047-vv5gpldi	276	38	easily	easily	RB
cord-302047-vv5gpldi	276	39	manipulated	manipulate	VBN
cord-302047-vv5gpldi	276	40	for	for	IN
cord-302047-vv5gpldi	276	41	the	the	DT
cord-302047-vv5gpldi	276	42	insertion	insertion	NN
cord-302047-vv5gpldi	276	43	of	of	IN
cord-302047-vv5gpldi	276	44	foreign	foreign	JJ
cord-302047-vv5gpldi	276	45	genes	gene	NNS
cord-302047-vv5gpldi	276	46	.	.	.
cord-302047-vv5gpldi	277	1	If	if	IN
cord-302047-vv5gpldi	277	2	correctly	correctly	RB
cord-302047-vv5gpldi	277	3	engineered	engineer	VBN
cord-302047-vv5gpldi	277	4	(	(	-LRB-
cord-302047-vv5gpldi	277	5	e.g.	e.g.	RB
cord-302047-vv5gpldi	277	6	without	without	IN
cord-302047-vv5gpldi	277	7	affecting	affect	VBG
cord-302047-vv5gpldi	277	8	any	any	DT
cord-302047-vv5gpldi	277	9	regulatory	regulatory	JJ
cord-302047-vv5gpldi	277	10	regions	region	NNS
cord-302047-vv5gpldi	277	11	)	)	-RRB-
cord-302047-vv5gpldi	277	12	,	,	,
cord-302047-vv5gpldi	277	13	one	one	PRP
cord-302047-vv5gpldi	277	14	could	could	MD
cord-302047-vv5gpldi	277	15	expect	expect	VB
cord-302047-vv5gpldi	277	16	that	that	IN
cord-302047-vv5gpldi	277	17	gene	gene	NN
cord-302047-vv5gpldi	277	18	insertions	insertion	NNS
cord-302047-vv5gpldi	277	19	are	be	VBP
cord-302047-vv5gpldi	277	20	more	more	RBR
cord-302047-vv5gpldi	277	21	stable	stable	JJ
cord-302047-vv5gpldi	277	22	in	in	IN
cord-302047-vv5gpldi	277	23	ssRNA(À	ssRNA(À	NNS
cord-302047-vv5gpldi	277	24	)	)	-RRB-
cord-302047-vv5gpldi	277	25	viruses	virus	NNS
cord-302047-vv5gpldi	277	26	as	as	IN
cord-302047-vv5gpldi	277	27	compared	compare	VBN
cord-302047-vv5gpldi	277	28	to	to	IN
cord-302047-vv5gpldi	277	29	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	277	30	)	)	-RRB-
cord-302047-vv5gpldi	277	31	viruses	virus	NNS
cord-302047-vv5gpldi	277	32	,	,	,
cord-302047-vv5gpldi	277	33	since	since	IN
cord-302047-vv5gpldi	277	34	the	the	DT
cord-302047-vv5gpldi	277	35	complexities	complexity	NNS
cord-302047-vv5gpldi	277	36	surrounding	surround	VBG
cord-302047-vv5gpldi	277	37	correct	correct	JJ
cord-302047-vv5gpldi	277	38	processing	processing	NN
cord-302047-vv5gpldi	277	39	of	of	IN
cord-302047-vv5gpldi	277	40	a	a	DT
cord-302047-vv5gpldi	277	41	polyprotein	polyprotein	NN
cord-302047-vv5gpldi	277	42	are	be	VBP
cord-302047-vv5gpldi	277	43	not	not	RB
cord-302047-vv5gpldi	277	44	an	an	DT
cord-302047-vv5gpldi	277	45	issue	issue	NN
cord-302047-vv5gpldi	277	46	here	here	RB
cord-302047-vv5gpldi	277	47	.	.	.
cord-302047-vv5gpldi	278	1	Moreover	moreover	RB
cord-302047-vv5gpldi	278	2	,	,	,
cord-302047-vv5gpldi	278	3	if	if	IN
cord-302047-vv5gpldi	278	4	expressed	express	VBN
cord-302047-vv5gpldi	278	5	as	as	IN
cord-302047-vv5gpldi	278	6	a	a	DT
cord-302047-vv5gpldi	278	7	separate	separate	JJ
cord-302047-vv5gpldi	278	8	mRNA	mrna	NN
cord-302047-vv5gpldi	278	9	,	,	,
cord-302047-vv5gpldi	278	10	the	the	DT
cord-302047-vv5gpldi	278	11	size	size	NN
cord-302047-vv5gpldi	278	12	of	of	IN
cord-302047-vv5gpldi	278	13	the	the	DT
cord-302047-vv5gpldi	278	14	insert	insert	NN
cord-302047-vv5gpldi	278	15	is	be	VBZ
cord-302047-vv5gpldi	278	16	probably	probably	RB
cord-302047-vv5gpldi	278	17	restricted	restrict	VBN
cord-302047-vv5gpldi	278	18	only	only	RB
cord-302047-vv5gpldi	278	19	by	by	IN
cord-302047-vv5gpldi	278	20	the	the	DT
cord-302047-vv5gpldi	278	21	packaging	packaging	NN
cord-302047-vv5gpldi	278	22	limits	limit	NNS
cord-302047-vv5gpldi	278	23	of	of	IN
cord-302047-vv5gpldi	278	24	ssRNA(À	ssRNA(À	NNS
cord-302047-vv5gpldi	278	25	)	)	-RRB-
cord-302047-vv5gpldi	278	26	viruses	virus	NNS
cord-302047-vv5gpldi	278	27	.	.	.
cord-302047-vv5gpldi	279	1	The	the	DT
cord-302047-vv5gpldi	279	2	low	low	JJ
cord-302047-vv5gpldi	279	3	rate	rate	NN
cord-302047-vv5gpldi	279	4	of	of	IN
cord-302047-vv5gpldi	279	5	homologous	homologous	JJ
cord-302047-vv5gpldi	279	6	recombination	recombination	NN
cord-302047-vv5gpldi	279	7	in	in	IN
cord-302047-vv5gpldi	279	8	ssRNA(À	ssRNA(À	NNS
cord-302047-vv5gpldi	279	9	)	)	-RRB-
cord-302047-vv5gpldi	279	10	viruses	virus	NNS
cord-302047-vv5gpldi	279	11	can	can	MD
cord-302047-vv5gpldi	279	12	be	be	VB
cord-302047-vv5gpldi	279	13	another	another	DT
cord-302047-vv5gpldi	279	14	explanation	explanation	NN
cord-302047-vv5gpldi	279	15	for	for	IN
cord-302047-vv5gpldi	279	16	higher	high	JJR
cord-302047-vv5gpldi	279	17	genomic	genomic	JJ
cord-302047-vv5gpldi	279	18	stability	stability	NN
cord-302047-vv5gpldi	279	19	(	(	-LRB-
cord-302047-vv5gpldi	279	20	Chare	Chare	NNP
cord-302047-vv5gpldi	279	21	,	,	,
cord-302047-vv5gpldi	279	22	Gould	Gould	NNP
cord-302047-vv5gpldi	279	23	,	,	,
cord-302047-vv5gpldi	279	24	and	and	CC
cord-302047-vv5gpldi	279	25	Holmes	Holmes	NNP
cord-302047-vv5gpldi	279	26	2003	2003	CD
cord-302047-vv5gpldi	279	27	;	;	:
cord-302047-vv5gpldi	279	28	Han	Han	NNP
cord-302047-vv5gpldi	279	29	and	and	CC
cord-302047-vv5gpldi	279	30	Worobey	Worobey	NNP
cord-302047-vv5gpldi	279	31	2011	2011	CD
cord-302047-vv5gpldi	279	32	)	)	-RRB-
cord-302047-vv5gpldi	279	33	.	.	.
cord-302047-vv5gpldi	280	1	Non	non	JJ
cord-302047-vv5gpldi	280	2	-	-	JJ
cord-302047-vv5gpldi	280	3	homologous	homologous	JJ
cord-302047-vv5gpldi	280	4	recombination	recombination	NN
cord-302047-vv5gpldi	280	5	will	will	MD
cord-302047-vv5gpldi	280	6	probably	probably	RB
cord-302047-vv5gpldi	280	7	rarely	rarely	RB
cord-302047-vv5gpldi	280	8	lead	lead	VB
cord-302047-vv5gpldi	280	9	to	to	IN
cord-302047-vv5gpldi	280	10	variants	variant	NNS
cord-302047-vv5gpldi	280	11	with	with	IN
cord-302047-vv5gpldi	280	12	the	the	DT
cord-302047-vv5gpldi	280	13	insert	insert	NN
cord-302047-vv5gpldi	280	14	deleted	delete	VBN
cord-302047-vv5gpldi	280	15	and	and	CC
cord-302047-vv5gpldi	280	16	other	other	JJ
cord-302047-vv5gpldi	280	17	regions	region	NNS
cord-302047-vv5gpldi	280	18	undisturbed	undisturbed	JJ
cord-302047-vv5gpldi	280	19	,	,	,
cord-302047-vv5gpldi	280	20	given	give	VBN
cord-302047-vv5gpldi	280	21	it	-PRON-	PRP
cord-302047-vv5gpldi	280	22	is	be	VBZ
cord-302047-vv5gpldi	280	23	less	less	RBR
cord-302047-vv5gpldi	280	24	constrained	constrained	JJ
cord-302047-vv5gpldi	280	25	than	than	IN
cord-302047-vv5gpldi	280	26	homologous	homologous	JJ
cord-302047-vv5gpldi	280	27	recombination	recombination	NN
cord-302047-vv5gpldi	280	28	,	,	,
cord-302047-vv5gpldi	280	29	and	and	CC
cord-302047-vv5gpldi	280	30	hence	hence	RB
cord-302047-vv5gpldi	280	31	low	low	JJ
cord-302047-vv5gpldi	280	32	homologous	homologous	JJ
cord-302047-vv5gpldi	280	33	recombination	recombination	NN
cord-302047-vv5gpldi	280	34	rates	rate	NNS
cord-302047-vv5gpldi	280	35	could	could	MD
cord-302047-vv5gpldi	280	36	be	be	VB
cord-302047-vv5gpldi	280	37	a	a	DT
cord-302047-vv5gpldi	280	38	limiting	limit	VBG
cord-302047-vv5gpldi	280	39	factor	factor	NN
cord-302047-vv5gpldi	280	40	on	on	IN
cord-302047-vv5gpldi	280	41	sequence	sequence	NN
cord-302047-vv5gpldi	280	42	evolution	evolution	NN
cord-302047-vv5gpldi	280	43	.	.	.
cord-302047-vv5gpldi	281	1	However	however	RB
cord-302047-vv5gpldi	281	2	,	,	,
cord-302047-vv5gpldi	281	3	genomic	genomic	JJ
cord-302047-vv5gpldi	281	4	deletions	deletion	NNS
cord-302047-vv5gpldi	281	5	that	that	WDT
cord-302047-vv5gpldi	281	6	disrupt	disrupt	VBP
cord-302047-vv5gpldi	281	7	the	the	DT
cord-302047-vv5gpldi	281	8	inserted	insert	VBN
cord-302047-vv5gpldi	281	9	sequence	sequence	NN
cord-302047-vv5gpldi	281	10	will	will	MD
cord-302047-vv5gpldi	281	11	be	be	VB
cord-302047-vv5gpldi	281	12	subject	subject	JJ
cord-302047-vv5gpldi	281	13	to	to	IN
cord-302047-vv5gpldi	281	14	less	less	JJR
cord-302047-vv5gpldi	281	15	constraints	constraint	NNS
cord-302047-vv5gpldi	281	16	,	,	,
cord-302047-vv5gpldi	281	17	as	as	IN
cord-302047-vv5gpldi	281	18	for	for	IN
cord-302047-vv5gpldi	281	19	example	example	NN
cord-302047-vv5gpldi	281	20	they	-PRON-	PRP
cord-302047-vv5gpldi	281	21	can	can	MD
cord-302047-vv5gpldi	281	22	disrupt	disrupt	VB
cord-302047-vv5gpldi	281	23	the	the	DT
cord-302047-vv5gpldi	281	24	reading	reading	NN
cord-302047-vv5gpldi	281	25	frame	frame	NN
cord-302047-vv5gpldi	281	26	of	of	IN
cord-302047-vv5gpldi	281	27	the	the	DT
cord-302047-vv5gpldi	281	28	insert	insert	NN
cord-302047-vv5gpldi	281	29	without	without	IN
cord-302047-vv5gpldi	281	30	affecting	affect	VBG
cord-302047-vv5gpldi	281	31	the	the	DT
cord-302047-vv5gpldi	281	32	expression	expression	NN
cord-302047-vv5gpldi	281	33	of	of	IN
cord-302047-vv5gpldi	281	34	virus	virus	NN
cord-302047-vv5gpldi	281	35	genes	gene	NNS
cord-302047-vv5gpldi	281	36	.	.	.
cord-302047-vv5gpldi	282	1	Canine	canine	JJ
cord-302047-vv5gpldi	282	2	distemper	distemper	NN
cord-302047-vv5gpldi	282	3	virus	virus	NN
cord-302047-vv5gpldi	282	4	(	(	-LRB-
cord-302047-vv5gpldi	282	5	CDV	CDV	NNP
cord-302047-vv5gpldi	282	6	)	)	-RRB-
cord-302047-vv5gpldi	282	7	,	,	,
cord-302047-vv5gpldi	282	8	a	a	DT
cord-302047-vv5gpldi	282	9	species	species	NN
cord-302047-vv5gpldi	282	10	in	in	IN
cord-302047-vv5gpldi	282	11	the	the	DT
cord-302047-vv5gpldi	282	12	Morbillivirus	Morbillivirus	NNP
cord-302047-vv5gpldi	282	13	genus	genus	NN
cord-302047-vv5gpldi	282	14	,	,	,
cord-302047-vv5gpldi	282	15	is	be	VBZ
cord-302047-vv5gpldi	282	16	an	an	DT
cord-302047-vv5gpldi	282	17	important	important	JJ
cord-302047-vv5gpldi	282	18	pathogen	pathogen	NN
cord-302047-vv5gpldi	282	19	of	of	IN
cord-302047-vv5gpldi	282	20	a	a	DT
cord-302047-vv5gpldi	282	21	variety	variety	NN
cord-302047-vv5gpldi	282	22	of	of	IN
cord-302047-vv5gpldi	282	23	animals	animal	NNS
cord-302047-vv5gpldi	282	24	,	,	,
cord-302047-vv5gpldi	282	25	including	include	VBG
cord-302047-vv5gpldi	282	26	the	the	DT
cord-302047-vv5gpldi	282	27	dog	dog	NN
cord-302047-vv5gpldi	282	28	.	.	.
cord-302047-vv5gpldi	283	1	This	this	DT
cord-302047-vv5gpldi	283	2	virus	virus	NN
cord-302047-vv5gpldi	283	3	,	,	,
cord-302047-vv5gpldi	283	4	however	however	RB
cord-302047-vv5gpldi	283	5	,	,	,
cord-302047-vv5gpldi	283	6	has	have	VBZ
cord-302047-vv5gpldi	283	7	shown	show	VBN
cord-302047-vv5gpldi	283	8	to	to	TO
cord-302047-vv5gpldi	283	9	be	be	VB
cord-302047-vv5gpldi	283	10	a	a	DT
cord-302047-vv5gpldi	283	11	promising	promising	JJ
cord-302047-vv5gpldi	283	12	expression	expression	NN
cord-302047-vv5gpldi	283	13	vector	vector	NN
cord-302047-vv5gpldi	283	14	for	for	IN
cord-302047-vv5gpldi	283	15	the	the	DT
cord-302047-vv5gpldi	283	16	development	development	NN
cord-302047-vv5gpldi	283	17	of	of	IN
cord-302047-vv5gpldi	283	18	vaccines	vaccine	NNS
cord-302047-vv5gpldi	283	19	.	.	.
cord-302047-vv5gpldi	284	1	Although	although	IN
cord-302047-vv5gpldi	284	2	the	the	DT
cord-302047-vv5gpldi	284	3	replicative	replicative	JJ
cord-302047-vv5gpldi	284	4	fitness	fitness	NN
cord-302047-vv5gpldi	284	5	of	of	IN
cord-302047-vv5gpldi	284	6	a	a	DT
cord-302047-vv5gpldi	284	7	recombinant	recombinant	JJ
cord-302047-vv5gpldi	284	8	CDV	CDV	NNP
cord-302047-vv5gpldi	284	9	carrying	carry	VBG
cord-302047-vv5gpldi	284	10	the	the	DT
cord-302047-vv5gpldi	284	11	rabies	rabies	NN
cord-302047-vv5gpldi	284	12	virus	virus	NN
cord-302047-vv5gpldi	284	13	glycoprotein	glycoprotein	NN
cord-302047-vv5gpldi	284	14	was	be	VBD
cord-302047-vv5gpldi	284	15	slightly	slightly	RB
cord-302047-vv5gpldi	284	16	lower	low	JJR
cord-302047-vv5gpldi	284	17	than	than	IN
cord-302047-vv5gpldi	284	18	the	the	DT
cord-302047-vv5gpldi	284	19	wild	wild	JJ
cord-302047-vv5gpldi	284	20	-	-	HYPH
cord-302047-vv5gpldi	284	21	type	type	NN
cord-302047-vv5gpldi	284	22	CDV	CDV	NNP
cord-302047-vv5gpldi	284	23	,	,	,
cord-302047-vv5gpldi	284	24	the	the	DT
cord-302047-vv5gpldi	284	25	insert	insert	NN
cord-302047-vv5gpldi	284	26	was	be	VBD
cord-302047-vv5gpldi	284	27	stably	stably	RB
cord-302047-vv5gpldi	284	28	expressed	express	VBN
cord-302047-vv5gpldi	284	29	during	during	IN
cord-302047-vv5gpldi	284	30	serial	serial	JJ
cord-302047-vv5gpldi	284	31	passaging	passaging	NN
cord-302047-vv5gpldi	284	32	in	in	IN
cord-302047-vv5gpldi	284	33	vitro	vitro	FW
cord-302047-vv5gpldi	284	34	and	and	CC
cord-302047-vv5gpldi	284	35	inoculation	inoculation	NN
cord-302047-vv5gpldi	284	36	in	in	IN
cord-302047-vv5gpldi	284	37	vivo	vivo	NN
cord-302047-vv5gpldi	284	38	induced	induce	VBN
cord-302047-vv5gpldi	284	39	specific	specific	JJ
cord-302047-vv5gpldi	284	40	neutralizing	neutralize	VBG
cord-302047-vv5gpldi	284	41	antibodies	antibody	NNS
cord-302047-vv5gpldi	284	42	against	against	IN
cord-302047-vv5gpldi	284	43	both	both	DT
cord-302047-vv5gpldi	284	44	rabies	rabie	NNS
cord-302047-vv5gpldi	284	45	and	and	CC
cord-302047-vv5gpldi	284	46	CDV	CDV	NNP
cord-302047-vv5gpldi	284	47	.	.	.
cord-302047-vv5gpldi	285	1	Similarly	similarly	RB
cord-302047-vv5gpldi	285	2	,	,	,
cord-302047-vv5gpldi	285	3	genes	gene	NNS
cord-302047-vv5gpldi	285	4	expressing	express	VBG
cord-302047-vv5gpldi	285	5	foreign	foreign	JJ
cord-302047-vv5gpldi	285	6	antigens	antigen	NNS
cord-302047-vv5gpldi	285	7	can	can	MD
cord-302047-vv5gpldi	285	8	be	be	VB
cord-302047-vv5gpldi	285	9	cloned	clone	VBN
cord-302047-vv5gpldi	285	10	into	into	IN
cord-302047-vv5gpldi	285	11	recombinant	recombinant	JJ
cord-302047-vv5gpldi	285	12	measles	measles	NN
cord-302047-vv5gpldi	285	13	virus	virus	NN
cord-302047-vv5gpldi	285	14	where	where	WRB
cord-302047-vv5gpldi	285	15	measles	measles	NN
cord-302047-vv5gpldi	285	16	virus	virus	NN
cord-302047-vv5gpldi	285	17	proteins	protein	NNS
cord-302047-vv5gpldi	285	18	and	and	CC
cord-302047-vv5gpldi	285	19	inserted	insert	VBN
cord-302047-vv5gpldi	285	20	genes	gene	NNS
cord-302047-vv5gpldi	285	21	are	be	VBP
cord-302047-vv5gpldi	285	22	coexpressed	coexpresse	VBN
cord-302047-vv5gpldi	285	23	.	.	.
cord-302047-vv5gpldi	286	1	This	this	DT
cord-302047-vv5gpldi	286	2	relatively	relatively	RB
cord-302047-vv5gpldi	286	3	small	small	JJ
cord-302047-vv5gpldi	286	4	vector	vector	NN
cord-302047-vv5gpldi	286	5	can	can	MD
cord-302047-vv5gpldi	286	6	accept	accept	VB
cord-302047-vv5gpldi	286	7	large	large	JJ
cord-302047-vv5gpldi	286	8	gene	gene	NN
cord-302047-vv5gpldi	286	9	insertions	insertion	NNS
cord-302047-vv5gpldi	286	10	,	,	,
cord-302047-vv5gpldi	286	11	that	that	IN
cord-302047-vv5gpldi	286	12	in	in	IN
cord-302047-vv5gpldi	286	13	most	most	JJS
cord-302047-vv5gpldi	286	14	cases	case	NNS
cord-302047-vv5gpldi	286	15	are	be	VBP
cord-302047-vv5gpldi	286	16	stably	stably	RB
cord-302047-vv5gpldi	286	17	expressed	express	VBN
cord-302047-vv5gpldi	286	18	(	(	-LRB-
cord-302047-vv5gpldi	286	19	Billeter	Billeter	NNP
cord-302047-vv5gpldi	286	20	,	,	,
cord-302047-vv5gpldi	286	21	Naim	Naim	NNP
cord-302047-vv5gpldi	286	22	,	,	,
cord-302047-vv5gpldi	286	23	and	and	CC
cord-302047-vv5gpldi	286	24	Udem	Udem	NNP
cord-302047-vv5gpldi	286	25	2009	2009	CD
cord-302047-vv5gpldi	286	26	;	;	:
cord-302047-vv5gpldi	287	1	Malczyk	Malczyk	NNP
cord-302047-vv5gpldi	287	2	et	et	NNP
cord-302047-vv5gpldi	287	3	al	al	NNP
cord-302047-vv5gpldi	287	4	.	.	NNP
cord-302047-vv5gpldi	287	5	2015	2015	CD
cord-302047-vv5gpldi	287	6	)	)	-RRB-
cord-302047-vv5gpldi	287	7	.	.	.
cord-302047-vv5gpldi	288	1	For	for	IN
cord-302047-vv5gpldi	288	2	example	example	NN
cord-302047-vv5gpldi	288	3	,	,	,
cord-302047-vv5gpldi	288	4	for	for	IN
cord-302047-vv5gpldi	288	5	the	the	DT
cord-302047-vv5gpldi	288	6	development	development	NN
cord-302047-vv5gpldi	288	7	of	of	IN
cord-302047-vv5gpldi	288	8	a	a	DT
cord-302047-vv5gpldi	288	9	vaccine	vaccine	NN
cord-302047-vv5gpldi	288	10	against	against	IN
cord-302047-vv5gpldi	288	11	Middle	Middle	NNP
cord-302047-vv5gpldi	288	12	East	East	NNP
cord-302047-vv5gpldi	288	13	respiratory	respiratory	JJ
cord-302047-vv5gpldi	288	14	syndrome	syndrome	NN
cord-302047-vv5gpldi	288	15	coronavirus	coronavirus	NN
cord-302047-vv5gpldi	288	16	(	(	-LRB-
cord-302047-vv5gpldi	288	17	MERS	MERS	NNP
cord-302047-vv5gpldi	288	18	-	-	HYPH
cord-302047-vv5gpldi	288	19	CoV	CoV	NNP
cord-302047-vv5gpldi	288	20	)	)	-RRB-
cord-302047-vv5gpldi	288	21	,	,	,
cord-302047-vv5gpldi	288	22	it	-PRON-	PRP
cord-302047-vv5gpldi	288	23	has	have	VBZ
cord-302047-vv5gpldi	288	24	been	be	VBN
cord-302047-vv5gpldi	288	25	shown	show	VBN
cord-302047-vv5gpldi	288	26	that	that	IN
cord-302047-vv5gpldi	288	27	a	a	DT
cord-302047-vv5gpldi	288	28	recombinant	recombinant	JJ
cord-302047-vv5gpldi	288	29	measles	measles	NN
cord-302047-vv5gpldi	288	30	virus	virus	NN
cord-302047-vv5gpldi	288	31	expressing	express	VBG
cord-302047-vv5gpldi	288	32	the	the	DT
cord-302047-vv5gpldi	288	33	spike	spike	NN
cord-302047-vv5gpldi	288	34	glycoprotein	glycoprotein	NN
cord-302047-vv5gpldi	288	35	of	of	IN
cord-302047-vv5gpldi	288	36	MERS	MERS	NNP
cord-302047-vv5gpldi	288	37	-	-	HYPH
cord-302047-vv5gpldi	288	38	CoV	CoV	NNP
cord-302047-vv5gpldi	288	39	is	be	VBZ
cord-302047-vv5gpldi	288	40	genetically	genetically	RB
cord-302047-vv5gpldi	288	41	stable	stable	JJ
cord-302047-vv5gpldi	288	42	in	in	IN
cord-302047-vv5gpldi	288	43	vitro	vitro	FW
cord-302047-vv5gpldi	288	44	and	and	CC
cord-302047-vv5gpldi	288	45	induces	induce	VBZ
cord-302047-vv5gpldi	288	46	strong	strong	JJ
cord-302047-vv5gpldi	288	47	humoral	humoral	JJ
cord-302047-vv5gpldi	288	48	and	and	CC
cord-302047-vv5gpldi	288	49	cellular	cellular	JJ
cord-302047-vv5gpldi	288	50	immunity	immunity	NN
cord-302047-vv5gpldi	288	51	in	in	IN
cord-302047-vv5gpldi	288	52	vivo	vivo	NN
cord-302047-vv5gpldi	289	1	(	(	-LRB-
cord-302047-vv5gpldi	289	2	Malczyk	Malczyk	NNP
cord-302047-vv5gpldi	289	3	et	et	NNP
cord-302047-vv5gpldi	289	4	al	al	NNP
cord-302047-vv5gpldi	289	5	.	.	NNP
cord-302047-vv5gpldi	289	6	2015	2015	CD
cord-302047-vv5gpldi	289	7	)	)	-RRB-
cord-302047-vv5gpldi	289	8	.	.	.
cord-302047-vv5gpldi	290	1	Vesicular	vesicular	JJ
cord-302047-vv5gpldi	290	2	stomatitis	stomatitis	NN
cord-302047-vv5gpldi	290	3	virus	virus	NN
cord-302047-vv5gpldi	290	4	(	(	-LRB-
cord-302047-vv5gpldi	290	5	VSV	VSV	NNP
cord-302047-vv5gpldi	290	6	)	)	-RRB-
cord-302047-vv5gpldi	290	7	is	be	VBZ
cord-302047-vv5gpldi	290	8	a	a	DT
cord-302047-vv5gpldi	290	9	commonly	commonly	RB
cord-302047-vv5gpldi	290	10	used	use	VBN
cord-302047-vv5gpldi	290	11	vaccine	vaccine	NN
cord-302047-vv5gpldi	290	12	vector	vector	NN
cord-302047-vv5gpldi	290	13	that	that	WDT
cord-302047-vv5gpldi	290	14	has	have	VBZ
cord-302047-vv5gpldi	290	15	been	be	VBN
cord-302047-vv5gpldi	290	16	engineered	engineer	VBN
cord-302047-vv5gpldi	290	17	to	to	TO
cord-302047-vv5gpldi	290	18	express	express	VB
cord-302047-vv5gpldi	290	19	surface	surface	NN
cord-302047-vv5gpldi	290	20	proteins	protein	NNS
cord-302047-vv5gpldi	290	21	from	from	IN
cord-302047-vv5gpldi	290	22	diverse	diverse	JJ
cord-302047-vv5gpldi	290	23	viruses	virus	NNS
cord-302047-vv5gpldi	290	24	,	,	,
cord-302047-vv5gpldi	290	25	including	include	VBG
cord-302047-vv5gpldi	290	26	Ebola	Ebola	NNP
cord-302047-vv5gpldi	290	27	(	(	-LRB-
cord-302047-vv5gpldi	290	28	Garbutt	Garbutt	NNP
cord-302047-vv5gpldi	290	29	et	et	NNP
cord-302047-vv5gpldi	290	30	al	al	NNP
cord-302047-vv5gpldi	290	31	.	.	.
cord-302047-vv5gpldi	290	32	2004	2004	CD
cord-302047-vv5gpldi	290	33	)	)	-RRB-
cord-302047-vv5gpldi	290	34	,	,	,
cord-302047-vv5gpldi	290	35	human	human	JJ
cord-302047-vv5gpldi	290	36	immunodeficiency	immunodeficiency	NN
cord-302047-vv5gpldi	290	37	virus	virus	NN
cord-302047-vv5gpldi	290	38	type	type	NN
cord-302047-vv5gpldi	290	39	1	1	CD
cord-302047-vv5gpldi	290	40	(	(	-LRB-
cord-302047-vv5gpldi	290	41	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	290	42	)	)	-RRB-
cord-302047-vv5gpldi	291	1	(	(	-LRB-
cord-302047-vv5gpldi	291	2	Johnson	Johnson	NNP
cord-302047-vv5gpldi	291	3	et	et	NNP
cord-302047-vv5gpldi	291	4	al	al	NNP
cord-302047-vv5gpldi	291	5	.	.	.
cord-302047-vv5gpldi	291	6	1997	1997	CD
cord-302047-vv5gpldi	291	7	)	)	-RRB-
cord-302047-vv5gpldi	291	8	,	,	,
cord-302047-vv5gpldi	291	9	and	and	CC
cord-302047-vv5gpldi	291	10	influenza	influenza	VB
cord-302047-vv5gpldi	291	11	A	a	NN
cord-302047-vv5gpldi	291	12	(	(	-LRB-
cord-302047-vv5gpldi	291	13	Roberts	Roberts	NNP
cord-302047-vv5gpldi	291	14	et	et	NNP
cord-302047-vv5gpldi	291	15	al	al	NNP
cord-302047-vv5gpldi	291	16	.	.	.
cord-302047-vv5gpldi	291	17	1999	1999	CD
cord-302047-vv5gpldi	291	18	)	)	-RRB-
cord-302047-vv5gpldi	291	19	,	,	,
cord-302047-vv5gpldi	291	20	which	which	WDT
cord-302047-vv5gpldi	291	21	can	can	MD
cord-302047-vv5gpldi	291	22	stimulate	stimulate	VB
cord-302047-vv5gpldi	291	23	protective	protective	JJ
cord-302047-vv5gpldi	291	24	immune	immune	JJ
cord-302047-vv5gpldi	291	25	responses	response	NNS
cord-302047-vv5gpldi	291	26	against	against	IN
cord-302047-vv5gpldi	291	27	these	these	DT
cord-302047-vv5gpldi	291	28	pathogens	pathogen	NNS
cord-302047-vv5gpldi	291	29	(	(	-LRB-
cord-302047-vv5gpldi	291	30	Bukreyev	Bukreyev	NNP
cord-302047-vv5gpldi	291	31	et	et	NNP
cord-302047-vv5gpldi	291	32	al	al	NNP
cord-302047-vv5gpldi	291	33	.	.	.
cord-302047-vv5gpldi	291	34	2006	2006	CD
cord-302047-vv5gpldi	291	35	)	)	-RRB-
cord-302047-vv5gpldi	291	36	.	.	.
cord-302047-vv5gpldi	292	1	In	in	IN
cord-302047-vv5gpldi	292	2	addition	addition	NN
cord-302047-vv5gpldi	292	3	,	,	,
cord-302047-vv5gpldi	292	4	VSV	VSV	NNP
cord-302047-vv5gpldi	292	5	has	have	VBZ
cord-302047-vv5gpldi	292	6	shown	show	VBN
cord-302047-vv5gpldi	292	7	promise	promise	NN
cord-302047-vv5gpldi	292	8	as	as	IN
cord-302047-vv5gpldi	292	9	a	a	DT
cord-302047-vv5gpldi	292	10	candidate	candidate	NN
cord-302047-vv5gpldi	292	11	for	for	IN
cord-302047-vv5gpldi	292	12	oncolytic	oncolytic	JJ
cord-302047-vv5gpldi	292	13	virus	virus	NN
cord-302047-vv5gpldi	292	14	therapy	therapy	NN
cord-302047-vv5gpldi	292	15	,	,	,
cord-302047-vv5gpldi	292	16	as	as	IN
cord-302047-vv5gpldi	292	17	it	-PRON-	PRP
cord-302047-vv5gpldi	292	18	replicates	replicate	VBZ
cord-302047-vv5gpldi	292	19	most	most	RBS
cord-302047-vv5gpldi	292	20	efficiently	efficiently	RB
cord-302047-vv5gpldi	292	21	in	in	IN
cord-302047-vv5gpldi	292	22	cells	cell	NNS
cord-302047-vv5gpldi	292	23	with	with	IN
cord-302047-vv5gpldi	292	24	diminished	diminish	VBN
cord-302047-vv5gpldi	292	25	innate	innate	JJ
cord-302047-vv5gpldi	292	26	immunity	immunity	NN
cord-302047-vv5gpldi	292	27	such	such	JJ
cord-302047-vv5gpldi	292	28	as	as	IN
cord-302047-vv5gpldi	292	29	cancer	cancer	NN
cord-302047-vv5gpldi	292	30	cells	cell	NNS
cord-302047-vv5gpldi	292	31	,	,	,
cord-302047-vv5gpldi	292	32	which	which	WDT
cord-302047-vv5gpldi	292	33	often	often	RB
cord-302047-vv5gpldi	292	34	have	have	VBP
cord-302047-vv5gpldi	292	35	impaired	impair	VBN
cord-302047-vv5gpldi	292	36	production	production	NN
cord-302047-vv5gpldi	292	37	of	of	IN
cord-302047-vv5gpldi	292	38	and/or	and/or	CC
cord-302047-vv5gpldi	292	39	response	response	NN
cord-302047-vv5gpldi	292	40	to	to	IN
cord-302047-vv5gpldi	292	41	interferon	interferon	NN
cord-302047-vv5gpldi	292	42	(	(	-LRB-
cord-302047-vv5gpldi	292	43	Barber	Barber	NNP
cord-302047-vv5gpldi	292	44	2005	2005	CD
cord-302047-vv5gpldi	292	45	)	)	-RRB-
cord-302047-vv5gpldi	292	46	.	.	.
cord-302047-vv5gpldi	293	1	Mutations	mutation	NNS
cord-302047-vv5gpldi	293	2	that	that	WDT
cord-302047-vv5gpldi	293	3	attenuate	attenuate	VBP
cord-302047-vv5gpldi	293	4	VSV	VSV	NNP
cord-302047-vv5gpldi	293	5	growth	growth	NN
cord-302047-vv5gpldi	293	6	in	in	IN
cord-302047-vv5gpldi	293	7	healthy	healthy	JJ
cord-302047-vv5gpldi	293	8	immune	immune	JJ
cord-302047-vv5gpldi	293	9	-	-	HYPH
cord-302047-vv5gpldi	293	10	competent	competent	JJ
cord-302047-vv5gpldi	293	11	cells	cell	NNS
cord-302047-vv5gpldi	293	12	can	can	MD
cord-302047-vv5gpldi	293	13	further	further	RB
cord-302047-vv5gpldi	293	14	enhance	enhance	VB
cord-302047-vv5gpldi	293	15	the	the	DT
cord-302047-vv5gpldi	293	16	safety	safety	NN
cord-302047-vv5gpldi	293	17	of	of	IN
cord-302047-vv5gpldi	293	18	this	this	DT
cord-302047-vv5gpldi	293	19	anti	anti	JJ
cord-302047-vv5gpldi	293	20	-	-	JJ
cord-302047-vv5gpldi	293	21	cancer	cancer	JJ
cord-302047-vv5gpldi	293	22	therapy	therapy	NN
cord-302047-vv5gpldi	293	23	potential	potential	NN
cord-302047-vv5gpldi	293	24	(	(	-LRB-
cord-302047-vv5gpldi	293	25	Barber	Barber	NNP
cord-302047-vv5gpldi	293	26	2005	2005	CD
cord-302047-vv5gpldi	293	27	)	)	-RRB-
cord-302047-vv5gpldi	293	28	.	.	.
cord-302047-vv5gpldi	294	1	What	what	WP
cord-302047-vv5gpldi	294	2	is	be	VBZ
cord-302047-vv5gpldi	294	3	particularly	particularly	RB
cord-302047-vv5gpldi	294	4	interesting	interesting	JJ
cord-302047-vv5gpldi	294	5	about	about	IN
cord-302047-vv5gpldi	294	6	the	the	DT
cord-302047-vv5gpldi	294	7	genome	genome	NN
cord-302047-vv5gpldi	294	8	organization	organization	NN
cord-302047-vv5gpldi	294	9	of	of	IN
cord-302047-vv5gpldi	294	10	VSV	VSV	NNP
cord-302047-vv5gpldi	294	11	and	and	CC
cord-302047-vv5gpldi	294	12	other	other	JJ
cord-302047-vv5gpldi	294	13	ssRNA(À	ssRNA(À	NNS
cord-302047-vv5gpldi	294	14	)	)	-RRB-
cord-302047-vv5gpldi	295	1	viruses	virus	NNS
cord-302047-vv5gpldi	295	2	is	be	VBZ
cord-302047-vv5gpldi	295	3	that	that	IN
cord-302047-vv5gpldi	295	4	promoter	promoter	NN
cord-302047-vv5gpldi	295	5	proximal	proximal	JJ
cord-302047-vv5gpldi	295	6	genes	gene	NNS
cord-302047-vv5gpldi	295	7	are	be	VBP
cord-302047-vv5gpldi	295	8	more	more	RBR
cord-302047-vv5gpldi	295	9	efficiently	efficiently	RB
cord-302047-vv5gpldi	295	10	expressed	express	VBN
cord-302047-vv5gpldi	295	11	than	than	IN
cord-302047-vv5gpldi	295	12	promoter	promoter	NN
cord-302047-vv5gpldi	295	13	distal	distal	JJ
cord-302047-vv5gpldi	295	14	ones	one	NNS
cord-302047-vv5gpldi	295	15	(	(	-LRB-
cord-302047-vv5gpldi	295	16	Iverson	Iverson	NNP
cord-302047-vv5gpldi	295	17	and	and	CC
cord-302047-vv5gpldi	295	18	Rose	Rose	NNP
cord-302047-vv5gpldi	295	19	1981	1981	CD
cord-302047-vv5gpldi	295	20	;	;	:
cord-302047-vv5gpldi	295	21	Wertz	Wertz	NNP
cord-302047-vv5gpldi	295	22	,	,	,
cord-302047-vv5gpldi	295	23	Perepelitsa	Perepelitsa	NNP
cord-302047-vv5gpldi	295	24	,	,	,
cord-302047-vv5gpldi	295	25	and	and	CC
cord-302047-vv5gpldi	295	26	Ball	Ball	NNP
cord-302047-vv5gpldi	295	27	1998	1998	CD
cord-302047-vv5gpldi	295	28	;	;	:
cord-302047-vv5gpldi	295	29	Pesko	Pesko	NNP
cord-302047-vv5gpldi	295	30	et	et	NNP
cord-302047-vv5gpldi	295	31	al	al	NNP
cord-302047-vv5gpldi	295	32	.	.	NNP
cord-302047-vv5gpldi	295	33	2015	2015	CD
cord-302047-vv5gpldi	295	34	)	)	-RRB-
cord-302047-vv5gpldi	295	35	.	.	.
cord-302047-vv5gpldi	296	1	The	the	DT
cord-302047-vv5gpldi	296	2	efficiency	efficiency	NN
cord-302047-vv5gpldi	296	3	of	of	IN
cord-302047-vv5gpldi	296	4	expression	expression	NN
cord-302047-vv5gpldi	296	5	of	of	IN
cord-302047-vv5gpldi	296	6	the	the	DT
cord-302047-vv5gpldi	296	7	inserted	insert	VBN
cord-302047-vv5gpldi	296	8	gene	gene	NN
cord-302047-vv5gpldi	296	9	(	(	-LRB-
cord-302047-vv5gpldi	296	10	and	and	CC
cord-302047-vv5gpldi	296	11	therewith	therewith	IN
cord-302047-vv5gpldi	296	12	the	the	DT
cord-302047-vv5gpldi	296	13	strength	strength	NN
cord-302047-vv5gpldi	296	14	of	of	IN
cord-302047-vv5gpldi	296	15	the	the	DT
cord-302047-vv5gpldi	296	16	immune	immune	JJ
cord-302047-vv5gpldi	296	17	response	response	NN
cord-302047-vv5gpldi	296	18	)	)	-RRB-
cord-302047-vv5gpldi	296	19	can	can	MD
cord-302047-vv5gpldi	296	20	be	be	VB
cord-302047-vv5gpldi	296	21	controlled	control	VBN
cord-302047-vv5gpldi	297	1	(	(	-LRB-
cord-302047-vv5gpldi	297	2	Tokusumi	Tokusumi	NNP
cord-302047-vv5gpldi	297	3	et	et	NNP
cord-302047-vv5gpldi	297	4	al	al	NNP
cord-302047-vv5gpldi	297	5	.	.	.
cord-302047-vv5gpldi	298	1	2002	2002	CD
cord-302047-vv5gpldi	298	2	;	;	:
cord-302047-vv5gpldi	298	3	Roberts	Roberts	NNP
cord-302047-vv5gpldi	298	4	et	et	NNP
cord-302047-vv5gpldi	298	5	al	al	NNP
cord-302047-vv5gpldi	298	6	.	.	.
cord-302047-vv5gpldi	298	7	2004	2004	CD
cord-302047-vv5gpldi	298	8	)	)	-RRB-
cord-302047-vv5gpldi	298	9	.	.	.
cord-302047-vv5gpldi	299	1	However	however	RB
cord-302047-vv5gpldi	299	2	,	,	,
cord-302047-vv5gpldi	299	3	inserting	insert	VBG
cord-302047-vv5gpldi	299	4	a	a	DT
cord-302047-vv5gpldi	299	5	foreign	foreign	JJ
cord-302047-vv5gpldi	299	6	gene	gene	NN
cord-302047-vv5gpldi	299	7	close	close	RB
cord-302047-vv5gpldi	299	8	to	to	IN
cord-302047-vv5gpldi	299	9	the	the	DT
cord-302047-vv5gpldi	299	10	promoter	promoter	NN
cord-302047-vv5gpldi	299	11	also	also	RB
cord-302047-vv5gpldi	299	12	can	can	MD
cord-302047-vv5gpldi	299	13	also	also	RB
cord-302047-vv5gpldi	299	14	reduce	reduce	VB
cord-302047-vv5gpldi	299	15	the	the	DT
cord-302047-vv5gpldi	299	16	expression	expression	NN
cord-302047-vv5gpldi	299	17	of	of	IN
cord-302047-vv5gpldi	299	18	downstream	downstream	JJ
cord-302047-vv5gpldi	299	19	vector	vector	NN
cord-302047-vv5gpldi	299	20	genes	gene	NNS
cord-302047-vv5gpldi	299	21	(	(	-LRB-
cord-302047-vv5gpldi	299	22	Skiadopoulos	Skiadopoulos	NNP
cord-302047-vv5gpldi	299	23	et	et	NNP
cord-302047-vv5gpldi	299	24	al	al	NNP
cord-302047-vv5gpldi	299	25	.	.	.
cord-302047-vv5gpldi	299	26	2002	2002	CD
cord-302047-vv5gpldi	299	27	)	)	-RRB-
cord-302047-vv5gpldi	299	28	,	,	,
cord-302047-vv5gpldi	299	29	which	which	WDT
cord-302047-vv5gpldi	299	30	in	in	IN
cord-302047-vv5gpldi	299	31	turn	turn	NN
cord-302047-vv5gpldi	299	32	can	can	MD
cord-302047-vv5gpldi	299	33	negatively	negatively	RB
cord-302047-vv5gpldi	299	34	affect	affect	VB
cord-302047-vv5gpldi	299	35	virus	virus	NN
cord-302047-vv5gpldi	299	36	transcription	transcription	NN
cord-302047-vv5gpldi	299	37	and	and	CC
cord-302047-vv5gpldi	299	38	RNA	RNA	NNP
cord-302047-vv5gpldi	299	39	replication	replication	NN
cord-302047-vv5gpldi	299	40	(	(	-LRB-
cord-302047-vv5gpldi	299	41	Wertz	Wertz	NNP
cord-302047-vv5gpldi	299	42	,	,	,
cord-302047-vv5gpldi	299	43	Moudy	Moudy	NNP
cord-302047-vv5gpldi	299	44	,	,	,
cord-302047-vv5gpldi	299	45	and	and	CC
cord-302047-vv5gpldi	299	46	Ball	Ball	NNP
cord-302047-vv5gpldi	299	47	2002	2002	CD
cord-302047-vv5gpldi	299	48	;	;	:
cord-302047-vv5gpldi	299	49	Zhao	Zhao	NNP
cord-302047-vv5gpldi	299	50	and	and	CC
cord-302047-vv5gpldi	299	51	Peeters	Peeters	NNP
cord-302047-vv5gpldi	299	52	2003	2003	CD
cord-302047-vv5gpldi	299	53	)	)	-RRB-
cord-302047-vv5gpldi	299	54	.	.	.
cord-302047-vv5gpldi	300	1	These	these	DT
cord-302047-vv5gpldi	300	2	empirical	empirical	JJ
cord-302047-vv5gpldi	300	3	observations	observation	NNS
cord-302047-vv5gpldi	300	4	again	again	RB
cord-302047-vv5gpldi	300	5	show	show	VBP
cord-302047-vv5gpldi	300	6	that	that	IN
cord-302047-vv5gpldi	300	7	the	the	DT
cord-302047-vv5gpldi	300	8	site	site	NN
cord-302047-vv5gpldi	300	9	of	of	IN
cord-302047-vv5gpldi	300	10	the	the	DT
cord-302047-vv5gpldi	300	11	insert	insert	NN
cord-302047-vv5gpldi	300	12	plays	play	VBZ
cord-302047-vv5gpldi	300	13	an	an	DT
cord-302047-vv5gpldi	300	14	important	important	JJ
cord-302047-vv5gpldi	300	15	role	role	NN
cord-302047-vv5gpldi	300	16	in	in	IN
cord-302047-vv5gpldi	300	17	recombinant	recombinant	JJ
cord-302047-vv5gpldi	300	18	vector	vector	NN
cord-302047-vv5gpldi	300	19	stability	stability	NN
cord-302047-vv5gpldi	300	20	.	.	.
cord-302047-vv5gpldi	301	1	When	when	WRB
cord-302047-vv5gpldi	301	2	considering	consider	VBG
cord-302047-vv5gpldi	301	3	the	the	DT
cord-302047-vv5gpldi	301	4	size	size	NN
cord-302047-vv5gpldi	301	5	of	of	IN
cord-302047-vv5gpldi	301	6	the	the	DT
cord-302047-vv5gpldi	301	7	insert	insert	NN
cord-302047-vv5gpldi	301	8	and	and	CC
cord-302047-vv5gpldi	301	9	its	-PRON-	PRP$
cord-302047-vv5gpldi	301	10	stability	stability	NN
cord-302047-vv5gpldi	301	11	,	,	,
cord-302047-vv5gpldi	301	12	ssRNA(À	ssRNA(À	NNS
cord-302047-vv5gpldi	301	13	)	)	-RRB-
cord-302047-vv5gpldi	301	14	viruses	virus	NNS
cord-302047-vv5gpldi	301	15	accept	accept	VBP
cord-302047-vv5gpldi	301	16	relatively	relatively	RB
cord-302047-vv5gpldi	301	17	large	large	JJ
cord-302047-vv5gpldi	301	18	insert	insert	NN
cord-302047-vv5gpldi	301	19	without	without	IN
cord-302047-vv5gpldi	301	20	drastically	drastically	RB
cord-302047-vv5gpldi	301	21	affecting	affect	VBG
cord-302047-vv5gpldi	301	22	virus	virus	NN
cord-302047-vv5gpldi	301	23	replication	replication	NN
cord-302047-vv5gpldi	301	24	.	.	.
cord-302047-vv5gpldi	302	1	Sendai	Sendai	NNP
cord-302047-vv5gpldi	302	2	virus	virus	NN
cord-302047-vv5gpldi	302	3	,	,	,
cord-302047-vv5gpldi	302	4	with	with	IN
cord-302047-vv5gpldi	302	5	a	a	DT
cord-302047-vv5gpldi	302	6	genome	genome	NN
cord-302047-vv5gpldi	302	7	size	size	NN
cord-302047-vv5gpldi	302	8	of	of	IN
cord-302047-vv5gpldi	302	9	about	about	IN
cord-302047-vv5gpldi	302	10	15.3	15.3	CD
cord-302047-vv5gpldi	302	11	kbp	kbp	NNS
cord-302047-vv5gpldi	302	12	,	,	,
cord-302047-vv5gpldi	302	13	can	can	MD
cord-302047-vv5gpldi	302	14	carry	carry	VB
cord-302047-vv5gpldi	302	15	and	and	CC
cord-302047-vv5gpldi	302	16	efficiently	efficiently	RB
cord-302047-vv5gpldi	302	17	express	express	VB
cord-302047-vv5gpldi	302	18	gene	gene	NN
cord-302047-vv5gpldi	302	19	insertions	insertion	NNS
cord-302047-vv5gpldi	302	20	up	up	IN
cord-302047-vv5gpldi	302	21	to	to	IN
cord-302047-vv5gpldi	302	22	3.2	3.2	CD
cord-302047-vv5gpldi	302	23	kbp	kbp	NNS
cord-302047-vv5gpldi	302	24	(	(	-LRB-
cord-302047-vv5gpldi	302	25	Sakai	Sakai	NNP
cord-302047-vv5gpldi	302	26	et	et	FW
cord-302047-vv5gpldi	302	27	al	al	NNP
cord-302047-vv5gpldi	302	28	.	.	.
cord-302047-vv5gpldi	302	29	1999	1999	CD
cord-302047-vv5gpldi	302	30	)	)	-RRB-
cord-302047-vv5gpldi	302	31	.	.	.
cord-302047-vv5gpldi	303	1	However	however	RB
cord-302047-vv5gpldi	303	2	,	,	,
cord-302047-vv5gpldi	303	3	also	also	RB
cord-302047-vv5gpldi	303	4	here	here	RB
cord-302047-vv5gpldi	303	5	the	the	DT
cord-302047-vv5gpldi	303	6	insert	insert	JJ
cord-302047-vv5gpldi	303	7	size	size	NN
cord-302047-vv5gpldi	303	8	is	be	VBZ
cord-302047-vv5gpldi	303	9	limited	limit	VBN
cord-302047-vv5gpldi	303	10	,	,	,
cord-302047-vv5gpldi	303	11	where	where	WRB
cord-302047-vv5gpldi	303	12	the	the	DT
cord-302047-vv5gpldi	303	13	final	final	JJ
cord-302047-vv5gpldi	303	14	virus	virus	NN
cord-302047-vv5gpldi	303	15	titers	titer	NNS
cord-302047-vv5gpldi	303	16	in	in	IN
cord-302047-vv5gpldi	303	17	vitro	vitro	NNS
cord-302047-vv5gpldi	303	18	are	be	VBP
cord-302047-vv5gpldi	303	19	proportionally	proportionally	RB
cord-302047-vv5gpldi	303	20	reduced	reduce	VBN
cord-302047-vv5gpldi	303	21	as	as	IN
cord-302047-vv5gpldi	303	22	the	the	DT
cord-302047-vv5gpldi	303	23	insert	insert	JJ
cord-302047-vv5gpldi	303	24	size	size	NN
cord-302047-vv5gpldi	303	25	increases	increase	NNS
cord-302047-vv5gpldi	303	26	.	.	.
cord-302047-vv5gpldi	304	1	While	while	IN
cord-302047-vv5gpldi	304	2	in	in	IN
cord-302047-vv5gpldi	304	3	vivo	vivo	FW
cord-302047-vv5gpldi	304	4	no	no	DT
cord-302047-vv5gpldi	304	5	such	such	JJ
cord-302047-vv5gpldi	304	6	size	size	NN
cord-302047-vv5gpldi	304	7	-	-	HYPH
cord-302047-vv5gpldi	304	8	dependent	dependent	JJ
cord-302047-vv5gpldi	304	9	effect	effect	NN
cord-302047-vv5gpldi	304	10	was	be	VBD
cord-302047-vv5gpldi	304	11	observed	observe	VBN
cord-302047-vv5gpldi	304	12	,	,	,
cord-302047-vv5gpldi	304	13	an	an	DT
cord-302047-vv5gpldi	304	14	attenuated	attenuated	JJ
cord-302047-vv5gpldi	304	15	replication	replication	NN
cord-302047-vv5gpldi	304	16	and	and	CC
cord-302047-vv5gpldi	304	17	pathogenicity	pathogenicity	NN
cord-302047-vv5gpldi	304	18	were	be	VBD
cord-302047-vv5gpldi	304	19	detected	detect	VBN
cord-302047-vv5gpldi	305	1	(	(	-LRB-
cord-302047-vv5gpldi	305	2	Sakai	Sakai	NNP
cord-302047-vv5gpldi	305	3	et	et	NNP
cord-302047-vv5gpldi	305	4	al	al	NNP
cord-302047-vv5gpldi	305	5	.	.	.
cord-302047-vv5gpldi	305	6	1999	1999	CD
cord-302047-vv5gpldi	305	7	)	)	-RRB-
cord-302047-vv5gpldi	305	8	.	.	.
cord-302047-vv5gpldi	306	1	Insertions	insertion	NNS
cord-302047-vv5gpldi	306	2	up	up	IN
cord-302047-vv5gpldi	306	3	to	to	IN
cord-302047-vv5gpldi	306	4	3.9	3.9	CD
cord-302047-vv5gpldi	306	5	kbp	kbp	NNS
cord-302047-vv5gpldi	306	6	in	in	IN
cord-302047-vv5gpldi	306	7	the	the	DT
cord-302047-vv5gpldi	306	8	$	$	$
cord-302047-vv5gpldi	306	9	15.4	15.4	CD
cord-302047-vv5gpldi	306	10	kbp	kbp	NNP
cord-302047-vv5gpldi	306	11	genome	genome	NN
cord-302047-vv5gpldi	306	12	of	of	IN
cord-302047-vv5gpldi	306	13	the	the	DT
cord-302047-vv5gpldi	306	14	human	human	JJ
cord-302047-vv5gpldi	306	15	parainfluenza	parainfluenza	NNP
cord-302047-vv5gpldi	306	16	virus	virus	NNP
cord-302047-vv5gpldi	306	17	3	3	CD
cord-302047-vv5gpldi	306	18	were	be	VBD
cord-302047-vv5gpldi	306	19	viable	viable	JJ
cord-302047-vv5gpldi	306	20	and	and	CC
cord-302047-vv5gpldi	306	21	replicated	replicate	VBN
cord-302047-vv5gpldi	306	22	efficiently	efficiently	RB
cord-302047-vv5gpldi	306	23	in	in	IN
cord-302047-vv5gpldi	306	24	vitro	vitro	FW
cord-302047-vv5gpldi	307	1	(	(	-LRB-
cord-302047-vv5gpldi	307	2	Skiadopoulos	Skiadopoulos	NNP
cord-302047-vv5gpldi	307	3	et	et	NNP
cord-302047-vv5gpldi	307	4	al	al	NNP
cord-302047-vv5gpldi	307	5	.	.	.
cord-302047-vv5gpldi	307	6	2000	2000	CD
cord-302047-vv5gpldi	307	7	)	)	-RRB-
cord-302047-vv5gpldi	307	8	.	.	.
cord-302047-vv5gpldi	308	1	Nonetheless	nonetheless	RB
cord-302047-vv5gpldi	308	2	,	,	,
cord-302047-vv5gpldi	308	3	the	the	DT
cord-302047-vv5gpldi	308	4	insertions	insertion	NNS
cord-302047-vv5gpldi	308	5	longer	long	RBR
cord-302047-vv5gpldi	308	6	than	than	IN
cord-302047-vv5gpldi	308	7	3,000	3,000	CD
cord-302047-vv5gpldi	308	8	bp	bp	NNP
cord-302047-vv5gpldi	308	9	reduced	reduce	VBD
cord-302047-vv5gpldi	308	10	the	the	DT
cord-302047-vv5gpldi	308	11	robustness	robustness	NN
cord-302047-vv5gpldi	308	12	to	to	IN
cord-302047-vv5gpldi	308	13	environmental	environmental	JJ
cord-302047-vv5gpldi	308	14	perturbation	perturbation	NN
cord-302047-vv5gpldi	308	15	of	of	IN
cord-302047-vv5gpldi	308	16	the	the	DT
cord-302047-vv5gpldi	308	17	virus	virus	NN
cord-302047-vv5gpldi	308	18	,	,	,
cord-302047-vv5gpldi	308	19	as	as	IN
cord-302047-vv5gpldi	308	20	temperature	temperature	NN
cord-302047-vv5gpldi	308	21	sensitivity	sensitivity	NN
cord-302047-vv5gpldi	308	22	was	be	VBD
cord-302047-vv5gpldi	308	23	augmented	augment	VBN
cord-302047-vv5gpldi	308	24	and	and	CC
cord-302047-vv5gpldi	308	25	replication	replication	NN
cord-302047-vv5gpldi	308	26	was	be	VBD
cord-302047-vv5gpldi	308	27	restricted	restrict	VBN
cord-302047-vv5gpldi	308	28	to	to	IN
cord-302047-vv5gpldi	308	29	certain	certain	JJ
cord-302047-vv5gpldi	308	30	sites	site	NNS
cord-302047-vv5gpldi	308	31	in	in	IN
cord-302047-vv5gpldi	308	32	vivo	vivo	NN
cord-302047-vv5gpldi	309	1	(	(	-LRB-
cord-302047-vv5gpldi	309	2	Skiadopoulos	Skiadopoulos	NNP
cord-302047-vv5gpldi	309	3	et	et	NNP
cord-302047-vv5gpldi	309	4	al	al	NNP
cord-302047-vv5gpldi	309	5	.	.	.
cord-302047-vv5gpldi	309	6	2000	2000	CD
cord-302047-vv5gpldi	309	7	)	)	-RRB-
cord-302047-vv5gpldi	309	8	.	.	.
cord-302047-vv5gpldi	310	1	The	the	DT
cord-302047-vv5gpldi	310	2	ssRNA(À	ssRNA(À	NNS
cord-302047-vv5gpldi	310	3	)	)	-RRB-
cord-302047-vv5gpldi	310	4	viruses	virus	NNS
cord-302047-vv5gpldi	310	5	seem	seem	VBP
cord-302047-vv5gpldi	310	6	promising	promising	JJ
cord-302047-vv5gpldi	310	7	expression	expression	NN
cord-302047-vv5gpldi	310	8	vectors	vector	NNS
cord-302047-vv5gpldi	310	9	,	,	,
cord-302047-vv5gpldi	310	10	where	where	WRB
cord-302047-vv5gpldi	310	11	one	one	PRP
cord-302047-vv5gpldi	310	12	can	can	MD
cord-302047-vv5gpldi	310	13	control	control	VB
cord-302047-vv5gpldi	310	14	gene	gene	NN
cord-302047-vv5gpldi	310	15	expression	expression	NN
cord-302047-vv5gpldi	310	16	and	and	CC
cord-302047-vv5gpldi	310	17	introduce	introduce	VB
cord-302047-vv5gpldi	310	18	relatively	relatively	RB
cord-302047-vv5gpldi	310	19	large	large	JJ
cord-302047-vv5gpldi	310	20	inserts	insert	NNS
cord-302047-vv5gpldi	310	21	that	that	WDT
cord-302047-vv5gpldi	310	22	,	,	,
cord-302047-vv5gpldi	310	23	in	in	IN
cord-302047-vv5gpldi	310	24	many	many	JJ
cord-302047-vv5gpldi	310	25	instances	instance	NNS
cord-302047-vv5gpldi	310	26	,	,	,
cord-302047-vv5gpldi	310	27	appear	appear	VBP
cord-302047-vv5gpldi	310	28	to	to	TO
cord-302047-vv5gpldi	310	29	be	be	VB
cord-302047-vv5gpldi	310	30	stable	stable	JJ
cord-302047-vv5gpldi	310	31	.	.	.
cord-302047-vv5gpldi	311	1	The	the	DT
cord-302047-vv5gpldi	311	2	constraints	constraint	NNS
cord-302047-vv5gpldi	311	3	imposed	impose	VBN
cord-302047-vv5gpldi	311	4	on	on	IN
cord-302047-vv5gpldi	311	5	viral	viral	JJ
cord-302047-vv5gpldi	311	6	gene	gene	NN
cord-302047-vv5gpldi	311	7	insertions	insertion	NNS
cord-302047-vv5gpldi	311	8	seem	seem	VBP
cord-302047-vv5gpldi	311	9	to	to	TO
cord-302047-vv5gpldi	311	10	be	be	VB
cord-302047-vv5gpldi	311	11	the	the	DT
cord-302047-vv5gpldi	311	12	lowest	low	JJS
cord-302047-vv5gpldi	311	13	in	in	IN
cord-302047-vv5gpldi	311	14	this	this	DT
cord-302047-vv5gpldi	311	15	group	group	NN
cord-302047-vv5gpldi	311	16	of	of	IN
cord-302047-vv5gpldi	311	17	viruses	virus	NNS
cord-302047-vv5gpldi	311	18	.	.	.
cord-302047-vv5gpldi	312	1	Yet	yet	RB
cord-302047-vv5gpldi	312	2	,	,	,
cord-302047-vv5gpldi	312	3	the	the	DT
cord-302047-vv5gpldi	312	4	ideal	ideal	JJ
cord-302047-vv5gpldi	312	5	vector	vector	NN
cord-302047-vv5gpldi	312	6	that	that	WDT
cord-302047-vv5gpldi	312	7	accepts	accept	VBZ
cord-302047-vv5gpldi	312	8	all	all	DT
cord-302047-vv5gpldi	312	9	types	type	NNS
cord-302047-vv5gpldi	312	10	and	and	CC
cord-302047-vv5gpldi	312	11	sizes	size	NNS
cord-302047-vv5gpldi	312	12	of	of	IN
cord-302047-vv5gpldi	312	13	foreign	foreign	JJ
cord-302047-vv5gpldi	312	14	gene	gene	NN
cord-302047-vv5gpldi	312	15	insertions	insertion	NNS
cord-302047-vv5gpldi	312	16	without	without	IN
cord-302047-vv5gpldi	312	17	decreasing	decrease	VBG
cord-302047-vv5gpldi	312	18	viral	viral	JJ
cord-302047-vv5gpldi	312	19	replication	replication	NN
cord-302047-vv5gpldi	312	20	,	,	,
cord-302047-vv5gpldi	312	21	has	have	VBZ
cord-302047-vv5gpldi	312	22	not	not	RB
cord-302047-vv5gpldi	312	23	been	be	VBN
cord-302047-vv5gpldi	312	24	identified	identify	VBN
cord-302047-vv5gpldi	312	25	yet	yet	RB
cord-302047-vv5gpldi	312	26	.	.	.
cord-302047-vv5gpldi	313	1	Retro	Retro	NNP
cord-302047-vv5gpldi	313	2	-	-	HYPH
cord-302047-vv5gpldi	313	3	transcribing	transcribe	VBG
cord-302047-vv5gpldi	313	4	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	313	5	)	)	-RRB-
cord-302047-vv5gpldi	313	6	viruses	virus	NNS
cord-302047-vv5gpldi	313	7	,	,	,
cord-302047-vv5gpldi	313	8	or	or	CC
cord-302047-vv5gpldi	313	9	retroviruses	retrovirus	NNS
cord-302047-vv5gpldi	313	10	,	,	,
cord-302047-vv5gpldi	313	11	are	be	VBP
cord-302047-vv5gpldi	313	12	small	small	JJ
cord-302047-vv5gpldi	313	13	viruses	virus	NNS
cord-302047-vv5gpldi	313	14	varying	vary	VBG
cord-302047-vv5gpldi	313	15	in	in	IN
cord-302047-vv5gpldi	313	16	genome	genome	NN
cord-302047-vv5gpldi	313	17	size	size	NN
cord-302047-vv5gpldi	313	18	from	from	IN
cord-302047-vv5gpldi	313	19	7	7	CD
cord-302047-vv5gpldi	313	20	to	to	TO
cord-302047-vv5gpldi	313	21	11	11	CD
cord-302047-vv5gpldi	313	22	kbp	kbp	NNS
cord-302047-vv5gpldi	313	23	and	and	CC
cord-302047-vv5gpldi	313	24	are	be	VBP
cord-302047-vv5gpldi	313	25	classified	classify	VBN
cord-302047-vv5gpldi	313	26	in	in	IN
cord-302047-vv5gpldi	313	27	the	the	DT
cord-302047-vv5gpldi	313	28	Retroviridae	Retroviridae	NNP
cord-302047-vv5gpldi	313	29	family	family	NN
cord-302047-vv5gpldi	313	30	.	.	.
cord-302047-vv5gpldi	314	1	After	after	IN
cord-302047-vv5gpldi	314	2	entering	enter	VBG
cord-302047-vv5gpldi	314	3	a	a	DT
cord-302047-vv5gpldi	314	4	host	host	NN
cord-302047-vv5gpldi	314	5	cell	cell	NN
cord-302047-vv5gpldi	314	6	,	,	,
cord-302047-vv5gpldi	314	7	the	the	DT
cord-302047-vv5gpldi	314	8	retroviral	retroviral	JJ
cord-302047-vv5gpldi	314	9	RNA	RNA	NNP
cord-302047-vv5gpldi	314	10	genome	genome	NN
cord-302047-vv5gpldi	314	11	is	be	VBZ
cord-302047-vv5gpldi	314	12	converted	convert	VBN
cord-302047-vv5gpldi	314	13	into	into	IN
cord-302047-vv5gpldi	314	14	dsDNA	dsdna	RB
cord-302047-vv5gpldi	314	15	by	by	IN
cord-302047-vv5gpldi	314	16	reverse	reverse	JJ
cord-302047-vv5gpldi	314	17	transcription	transcription	NN
cord-302047-vv5gpldi	314	18	.	.	.
cord-302047-vv5gpldi	315	1	The	the	DT
cord-302047-vv5gpldi	315	2	viral	viral	JJ
cord-302047-vv5gpldi	315	3	DNA	dna	NN
cord-302047-vv5gpldi	315	4	integrates	integrate	VBZ
cord-302047-vv5gpldi	315	5	into	into	IN
cord-302047-vv5gpldi	315	6	the	the	DT
cord-302047-vv5gpldi	315	7	host	host	NN
cord-302047-vv5gpldi	315	8	genome	genome	NN
cord-302047-vv5gpldi	315	9	,	,	,
cord-302047-vv5gpldi	315	10	where	where	WRB
cord-302047-vv5gpldi	315	11	viral	viral	JJ
cord-302047-vv5gpldi	315	12	genes	gene	NNS
cord-302047-vv5gpldi	315	13	are	be	VBP
cord-302047-vv5gpldi	315	14	translated	translate	VBN
cord-302047-vv5gpldi	315	15	.	.	.
cord-302047-vv5gpldi	316	1	Therefore	therefore	RB
cord-302047-vv5gpldi	316	2	,	,	,
cord-302047-vv5gpldi	316	3	these	these	DT
cord-302047-vv5gpldi	316	4	viruses	virus	NNS
cord-302047-vv5gpldi	316	5	are	be	VBP
cord-302047-vv5gpldi	316	6	often	often	RB
cord-302047-vv5gpldi	316	7	used	use	VBN
cord-302047-vv5gpldi	316	8	for	for	IN
cord-302047-vv5gpldi	316	9	gene	gene	NN
cord-302047-vv5gpldi	316	10	therapy	therapy	NN
cord-302047-vv5gpldi	316	11	.	.	.
cord-302047-vv5gpldi	317	1	Retroviruses	retrovirus	NNS
cord-302047-vv5gpldi	317	2	frequently	frequently	RB
cord-302047-vv5gpldi	317	3	undergo	undergo	VBP
cord-302047-vv5gpldi	317	4	genomic	genomic	JJ
cord-302047-vv5gpldi	317	5	rearrangements	rearrangement	NNS
cord-302047-vv5gpldi	317	6	,	,	,
cord-302047-vv5gpldi	317	7	including	include	VBG
cord-302047-vv5gpldi	317	8	gene	gene	NN
cord-302047-vv5gpldi	317	9	insertions	insertion	NNS
cord-302047-vv5gpldi	317	10	and	and	CC
cord-302047-vv5gpldi	317	11	deletions	deletion	NNS
cord-302047-vv5gpldi	317	12	(	(	-LRB-
cord-302047-vv5gpldi	317	13	indels	indel	NNS
cord-302047-vv5gpldi	317	14	)	)	-RRB-
cord-302047-vv5gpldi	317	15	.	.	.
cord-302047-vv5gpldi	318	1	Moreover	moreover	RB
cord-302047-vv5gpldi	318	2	,	,	,
cord-302047-vv5gpldi	318	3	recombination	recombination	NN
cord-302047-vv5gpldi	318	4	can	can	MD
cord-302047-vv5gpldi	318	5	be	be	VB
cord-302047-vv5gpldi	318	6	common	common	JJ
cord-302047-vv5gpldi	318	7	due	due	IN
cord-302047-vv5gpldi	318	8	to	to	IN
cord-302047-vv5gpldi	318	9	the	the	DT
cord-302047-vv5gpldi	318	10	combination	combination	NN
cord-302047-vv5gpldi	318	11	of	of	IN
cord-302047-vv5gpldi	318	12	'	'	``
cord-302047-vv5gpldi	318	13	diploid	diploid	JJ
cord-302047-vv5gpldi	318	14	'	'	''
cord-302047-vv5gpldi	318	15	virus	virus	NN
cord-302047-vv5gpldi	318	16	particles	particle	NNS
cord-302047-vv5gpldi	318	17	and	and	CC
cord-302047-vv5gpldi	318	18	high	high	JJ
cord-302047-vv5gpldi	318	19	intrinsic	intrinsic	JJ
cord-302047-vv5gpldi	318	20	recombination	recombination	NN
cord-302047-vv5gpldi	318	21	rates	rate	NNS
cord-302047-vv5gpldi	318	22	(	(	-LRB-
cord-302047-vv5gpldi	318	23	Jetzt	Jetzt	NNP
cord-302047-vv5gpldi	318	24	et	et	FW
cord-302047-vv5gpldi	318	25	al	al	NNP
cord-302047-vv5gpldi	318	26	.	.	.
cord-302047-vv5gpldi	318	27	2000	2000	CD
cord-302047-vv5gpldi	318	28	)	)	-RRB-
cord-302047-vv5gpldi	318	29	.	.	.
cord-302047-vv5gpldi	319	1	Therefore	therefore	RB
cord-302047-vv5gpldi	319	2	as	as	IN
cord-302047-vv5gpldi	319	3	a	a	DT
cord-302047-vv5gpldi	319	4	general	general	JJ
cord-302047-vv5gpldi	319	5	observation	observation	NN
cord-302047-vv5gpldi	319	6	this	this	DT
cord-302047-vv5gpldi	319	7	viral	viral	JJ
cord-302047-vv5gpldi	319	8	group	group	NN
cord-302047-vv5gpldi	319	9	appears	appear	VBZ
cord-302047-vv5gpldi	319	10	to	to	TO
cord-302047-vv5gpldi	319	11	have	have	VB
cord-302047-vv5gpldi	319	12	a	a	DT
cord-302047-vv5gpldi	319	13	highly	highly	RB
cord-302047-vv5gpldi	319	14	plastic	plastic	JJ
cord-302047-vv5gpldi	319	15	genome	genome	NN
cord-302047-vv5gpldi	319	16	,	,	,
cord-302047-vv5gpldi	319	17	and	and	CC
cord-302047-vv5gpldi	319	18	should	should	MD
cord-302047-vv5gpldi	319	19	be	be	VB
cord-302047-vv5gpldi	319	20	relatively	relatively	RB
cord-302047-vv5gpldi	319	21	open	open	JJ
cord-302047-vv5gpldi	319	22	to	to	IN
cord-302047-vv5gpldi	319	23	foreign	foreign	JJ
cord-302047-vv5gpldi	319	24	gene	gene	NN
cord-302047-vv5gpldi	319	25	insertions	insertion	NNS
cord-302047-vv5gpldi	319	26	.	.	.
cord-302047-vv5gpldi	320	1	As	as	IN
cord-302047-vv5gpldi	320	2	retroviruses	retrovirus	NNS
cord-302047-vv5gpldi	320	3	integrate	integrate	VBP
cord-302047-vv5gpldi	320	4	into	into	IN
cord-302047-vv5gpldi	320	5	the	the	DT
cord-302047-vv5gpldi	320	6	host	host	NN
cord-302047-vv5gpldi	320	7	genome	genome	NN
cord-302047-vv5gpldi	320	8	,	,	,
cord-302047-vv5gpldi	320	9	the	the	DT
cord-302047-vv5gpldi	320	10	stability	stability	NN
cord-302047-vv5gpldi	320	11	of	of	IN
cord-302047-vv5gpldi	320	12	inserts	insert	NNS
cord-302047-vv5gpldi	320	13	does	do	VBZ
cord-302047-vv5gpldi	320	14	not	not	RB
cord-302047-vv5gpldi	320	15	necessarily	necessarily	RB
cord-302047-vv5gpldi	320	16	depend	depend	VB
cord-302047-vv5gpldi	320	17	solely	solely	RB
cord-302047-vv5gpldi	320	18	on	on	IN
cord-302047-vv5gpldi	320	19	the	the	DT
cord-302047-vv5gpldi	320	20	retrovirus	retrovirus	NN
cord-302047-vv5gpldi	320	21	genome	genome	NN
cord-302047-vv5gpldi	320	22	configuration	configuration	NN
cord-302047-vv5gpldi	320	23	and	and	CC
cord-302047-vv5gpldi	320	24	demographic	demographic	JJ
cord-302047-vv5gpldi	320	25	conditions	condition	NNS
cord-302047-vv5gpldi	320	26	.	.	.
cord-302047-vv5gpldi	321	1	As	as	IN
cord-302047-vv5gpldi	321	2	host	host	NN
cord-302047-vv5gpldi	321	3	genomes	genome	NNS
cord-302047-vv5gpldi	321	4	are	be	VBP
cord-302047-vv5gpldi	321	5	in	in	IN
cord-302047-vv5gpldi	321	6	general	general	JJ
cord-302047-vv5gpldi	321	7	less	less	RBR
cord-302047-vv5gpldi	321	8	streamlined	streamlined	JJ
cord-302047-vv5gpldi	321	9	than	than	IN
cord-302047-vv5gpldi	321	10	those	those	DT
cord-302047-vv5gpldi	321	11	of	of	IN
cord-302047-vv5gpldi	321	12	viruses	virus	NNS
cord-302047-vv5gpldi	321	13	,	,	,
cord-302047-vv5gpldi	321	14	one	one	PRP
cord-302047-vv5gpldi	321	15	could	could	MD
cord-302047-vv5gpldi	321	16	expect	expect	VB
cord-302047-vv5gpldi	321	17	that	that	IN
cord-302047-vv5gpldi	321	18	gene	gene	NN
cord-302047-vv5gpldi	321	19	insertions	insertion	NNS
cord-302047-vv5gpldi	321	20	are	be	VBP
cord-302047-vv5gpldi	321	21	stable	stable	JJ
cord-302047-vv5gpldi	321	22	after	after	IN
cord-302047-vv5gpldi	321	23	integration	integration	NN
cord-302047-vv5gpldi	321	24	into	into	IN
cord-302047-vv5gpldi	321	25	the	the	DT
cord-302047-vv5gpldi	321	26	host	host	NN
cord-302047-vv5gpldi	321	27	genome	genome	NN
cord-302047-vv5gpldi	321	28	.	.	.
cord-302047-vv5gpldi	322	1	However	however	RB
cord-302047-vv5gpldi	322	2	,	,	,
cord-302047-vv5gpldi	322	3	the	the	DT
cord-302047-vv5gpldi	322	4	random	random	JJ
cord-302047-vv5gpldi	322	5	integration	integration	NN
cord-302047-vv5gpldi	322	6	of	of	IN
cord-302047-vv5gpldi	322	7	retroviruses	retrovirus	NNS
cord-302047-vv5gpldi	322	8	in	in	IN
cord-302047-vv5gpldi	322	9	the	the	DT
cord-302047-vv5gpldi	322	10	host	host	NN
cord-302047-vv5gpldi	322	11	genome	genome	NN
cord-302047-vv5gpldi	322	12	makes	make	VBZ
cord-302047-vv5gpldi	322	13	it	-PRON-	PRP
cord-302047-vv5gpldi	322	14	hard	hard	JJ
cord-302047-vv5gpldi	322	15	to	to	TO
cord-302047-vv5gpldi	322	16	predict	predict	VB
cord-302047-vv5gpldi	322	17	genomic	genomic	JJ
cord-302047-vv5gpldi	322	18	stability	stability	NN
cord-302047-vv5gpldi	322	19	.	.	.
cord-302047-vv5gpldi	323	1	As	as	IN
cord-302047-vv5gpldi	323	2	a	a	DT
cord-302047-vv5gpldi	323	3	wild	wild	JJ
cord-302047-vv5gpldi	323	4	example	example	NN
cord-302047-vv5gpldi	323	5	,	,	,
cord-302047-vv5gpldi	323	6	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	323	7	frequently	frequently	RB
cord-302047-vv5gpldi	323	8	undergoes	undergo	VBZ
cord-302047-vv5gpldi	323	9	genomic	genomic	JJ
cord-302047-vv5gpldi	323	10	rearrangements	rearrangement	NNS
cord-302047-vv5gpldi	323	11	,	,	,
cord-302047-vv5gpldi	323	12	where	where	WRB
cord-302047-vv5gpldi	323	13	indels	indel	NNS
cord-302047-vv5gpldi	323	14	are	be	VBP
cord-302047-vv5gpldi	323	15	significant	significant	JJ
cord-302047-vv5gpldi	323	16	source	source	NN
cord-302047-vv5gpldi	323	17	of	of	IN
cord-302047-vv5gpldi	323	18	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	323	19	change	change	NN
cord-302047-vv5gpldi	323	20	.	.	.
cord-302047-vv5gpldi	324	1	These	these	DT
cord-302047-vv5gpldi	324	2	indels	indel	NNS
cord-302047-vv5gpldi	324	3	appear	appear	VBP
cord-302047-vv5gpldi	324	4	to	to	TO
cord-302047-vv5gpldi	324	5	have	have	VB
cord-302047-vv5gpldi	324	6	an	an	DT
cord-302047-vv5gpldi	324	7	impact	impact	NN
cord-302047-vv5gpldi	324	8	on	on	IN
cord-302047-vv5gpldi	324	9	virus	virus	NN
cord-302047-vv5gpldi	324	10	transmission	transmission	NN
cord-302047-vv5gpldi	324	11	and	and	CC
cord-302047-vv5gpldi	324	12	adaptation	adaptation	NN
cord-302047-vv5gpldi	324	13	as	as	IN
cord-302047-vv5gpldi	324	14	for	for	IN
cord-302047-vv5gpldi	324	15	example	example	NN
cord-302047-vv5gpldi	324	16	indels	indel	NNS
cord-302047-vv5gpldi	324	17	in	in	IN
cord-302047-vv5gpldi	324	18	the	the	DT
cord-302047-vv5gpldi	324	19	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	324	20	pol	pol	NN
cord-302047-vv5gpldi	324	21	gene	gene	NN
cord-302047-vv5gpldi	324	22	are	be	VBP
cord-302047-vv5gpldi	324	23	associated	associate	VBN
cord-302047-vv5gpldi	324	24	with	with	IN
cord-302047-vv5gpldi	324	25	drug	drug	NN
cord-302047-vv5gpldi	324	26	resistance	resistance	NN
cord-302047-vv5gpldi	324	27	(	(	-LRB-
cord-302047-vv5gpldi	324	28	Rakik	Rakik	NNP
cord-302047-vv5gpldi	324	29	et	et	NNP
cord-302047-vv5gpldi	324	30	al	al	NNP
cord-302047-vv5gpldi	324	31	.	.	.
cord-302047-vv5gpldi	324	32	1999	1999	CD
cord-302047-vv5gpldi	324	33	)	)	-RRB-
cord-302047-vv5gpldi	324	34	,	,	,
cord-302047-vv5gpldi	324	35	and	and	CC
cord-302047-vv5gpldi	324	36	indels	indel	NNS
cord-302047-vv5gpldi	324	37	in	in	IN
cord-302047-vv5gpldi	324	38	the	the	DT
cord-302047-vv5gpldi	324	39	gag	gag	NN
cord-302047-vv5gpldi	324	40	and	and	CC
cord-302047-vv5gpldi	324	41	vif	vif	NN
cord-302047-vv5gpldi	324	42	genes	gene	NNS
cord-302047-vv5gpldi	324	43	are	be	VBP
cord-302047-vv5gpldi	324	44	associated	associate	VBN
cord-302047-vv5gpldi	324	45	with	with	IN
cord-302047-vv5gpldi	324	46	disease	disease	NN
cord-302047-vv5gpldi	324	47	progression	progression	NN
cord-302047-vv5gpldi	324	48	and	and	CC
cord-302047-vv5gpldi	324	49	infectivity	infectivity	NN
cord-302047-vv5gpldi	324	50	(	(	-LRB-
cord-302047-vv5gpldi	324	51	Alexander	Alexander	NNP
cord-302047-vv5gpldi	324	52	et	et	NNP
cord-302047-vv5gpldi	324	53	al	al	NNP
cord-302047-vv5gpldi	324	54	.	.	.
cord-302047-vv5gpldi	324	55	2002	2002	CD
cord-302047-vv5gpldi	324	56	;	;	:
cord-302047-vv5gpldi	324	57	Aralaguppe	Aralaguppe	NNP
cord-302047-vv5gpldi	324	58	et	et	NNP
cord-302047-vv5gpldi	324	59	al	al	NNP
cord-302047-vv5gpldi	324	60	.	.	.
cord-302047-vv5gpldi	324	61	2017	2017	CD
cord-302047-vv5gpldi	324	62	)	)	-RRB-
cord-302047-vv5gpldi	324	63	.	.	.
cord-302047-vv5gpldi	325	1	The	the	DT
cord-302047-vv5gpldi	325	2	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	325	3	surface	surface	NN
cord-302047-vv5gpldi	325	4	envelope	envelope	NN
cord-302047-vv5gpldi	325	5	glycoprotein	glycoprotein	NN
cord-302047-vv5gpldi	325	6	contains	contain	VBZ
cord-302047-vv5gpldi	325	7	five	five	CD
cord-302047-vv5gpldi	325	8	variable	variable	JJ
cord-302047-vv5gpldi	325	9	regions	region	NNS
cord-302047-vv5gpldi	325	10	(	(	-LRB-
cord-302047-vv5gpldi	325	11	V1-V5	v1-v5	NN
cord-302047-vv5gpldi	325	12	)	)	-RRB-
cord-302047-vv5gpldi	325	13	that	that	WDT
cord-302047-vv5gpldi	325	14	can	can	MD
cord-302047-vv5gpldi	325	15	tolerate	tolerate	VB
cord-302047-vv5gpldi	325	16	a	a	DT
cord-302047-vv5gpldi	325	17	higher	high	JJR
cord-302047-vv5gpldi	325	18	rate	rate	NN
cord-302047-vv5gpldi	325	19	of	of	IN
cord-302047-vv5gpldi	325	20	indels	indel	NNS
cord-302047-vv5gpldi	325	21	than	than	IN
cord-302047-vv5gpldi	325	22	the	the	DT
cord-302047-vv5gpldi	325	23	rest	rest	NN
cord-302047-vv5gpldi	325	24	of	of	IN
cord-302047-vv5gpldi	325	25	the	the	DT
cord-302047-vv5gpldi	325	26	genome	genome	NN
cord-302047-vv5gpldi	325	27	.	.	.
cord-302047-vv5gpldi	326	1	Interestingly	interestingly	RB
cord-302047-vv5gpldi	326	2	,	,	,
cord-302047-vv5gpldi	326	3	indel	indel	NN
cord-302047-vv5gpldi	326	4	rate	rate	NN
cord-302047-vv5gpldi	326	5	estimates	estimate	NNS
cord-302047-vv5gpldi	326	6	vary	vary	VBP
cord-302047-vv5gpldi	326	7	significantly	significantly	RB
cord-302047-vv5gpldi	326	8	among	among	IN
cord-302047-vv5gpldi	326	9	variable	variable	JJ
cord-302047-vv5gpldi	326	10	regions	region	NNS
cord-302047-vv5gpldi	326	11	and	and	CC
cord-302047-vv5gpldi	326	12	subtypes	subtype	NNS
cord-302047-vv5gpldi	326	13	(	(	-LRB-
cord-302047-vv5gpldi	326	14	from	from	IN
cord-302047-vv5gpldi	326	15	different	different	JJ
cord-302047-vv5gpldi	326	16	hosts	host	NNS
cord-302047-vv5gpldi	326	17	)	)	-RRB-
cord-302047-vv5gpldi	327	1	(	(	-LRB-
cord-302047-vv5gpldi	327	2	Palmer	Palmer	NNP
cord-302047-vv5gpldi	327	3	and	and	CC
cord-302047-vv5gpldi	327	4	Poon	Poon	NNP
cord-302047-vv5gpldi	327	5	2018	2018	CD
cord-302047-vv5gpldi	327	6	)	)	-RRB-
cord-302047-vv5gpldi	327	7	.	.	.
cord-302047-vv5gpldi	328	1	When	when	WRB
cord-302047-vv5gpldi	328	2	introducing	introduce	VBG
cord-302047-vv5gpldi	328	3	GFP	GFP	NNP
cord-302047-vv5gpldi	328	4	into	into	IN
cord-302047-vv5gpldi	328	5	the	the	DT
cord-302047-vv5gpldi	328	6	five	five	CD
cord-302047-vv5gpldi	328	7	variable	variable	JJ
cord-302047-vv5gpldi	328	8	regions	region	NNS
cord-302047-vv5gpldi	328	9	of	of	IN
cord-302047-vv5gpldi	328	10	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	328	11	,	,	,
cord-302047-vv5gpldi	328	12	certain	certain	JJ
cord-302047-vv5gpldi	328	13	regions	region	NNS
cord-302047-vv5gpldi	328	14	(	(	-LRB-
cord-302047-vv5gpldi	328	15	V4	v4	NN
cord-302047-vv5gpldi	328	16	and	and	CC
cord-302047-vv5gpldi	328	17	V5	V5	NNP
cord-302047-vv5gpldi	328	18	)	)	-RRB-
cord-302047-vv5gpldi	328	19	were	be	VBD
cord-302047-vv5gpldi	328	20	more	more	RBR
cord-302047-vv5gpldi	328	21	tolerant	tolerant	JJ
cord-302047-vv5gpldi	328	22	to	to	IN
cord-302047-vv5gpldi	328	23	foreign	foreign	JJ
cord-302047-vv5gpldi	328	24	gene	gene	NN
cord-302047-vv5gpldi	328	25	insertions	insertion	NNS
cord-302047-vv5gpldi	328	26	than	than	IN
cord-302047-vv5gpldi	328	27	the	the	DT
cord-302047-vv5gpldi	328	28	other	other	JJ
cord-302047-vv5gpldi	328	29	variable	variable	JJ
cord-302047-vv5gpldi	328	30	regions	region	NNS
cord-302047-vv5gpldi	328	31	(	(	-LRB-
cord-302047-vv5gpldi	328	32	V1	V1	NNS
cord-302047-vv5gpldi	328	33	,	,	,
cord-302047-vv5gpldi	328	34	V2	v2	NN
cord-302047-vv5gpldi	328	35	,	,	,
cord-302047-vv5gpldi	328	36	and	and	CC
cord-302047-vv5gpldi	328	37	V3	v3	NN
cord-302047-vv5gpldi	328	38	)	)	-RRB-
cord-302047-vv5gpldi	329	1	(	(	-LRB-
cord-302047-vv5gpldi	329	2	Nakane	Nakane	NNP
cord-302047-vv5gpldi	329	3	,	,	,
cord-302047-vv5gpldi	329	4	Iwamoto	Iwamoto	NNP
cord-302047-vv5gpldi	329	5	,	,	,
cord-302047-vv5gpldi	329	6	and	and	CC
cord-302047-vv5gpldi	329	7	Matsuda	Matsuda	NNP
cord-302047-vv5gpldi	329	8	2015	2015	CD
cord-302047-vv5gpldi	329	9	)	)	-RRB-
cord-302047-vv5gpldi	329	10	.	.	.
cord-302047-vv5gpldi	330	1	In	in	IN
cord-302047-vv5gpldi	330	2	particular	particular	JJ
cord-302047-vv5gpldi	330	3	,	,	,
cord-302047-vv5gpldi	330	4	GFP	GFP	NNP
cord-302047-vv5gpldi	330	5	insertions	insertion	NNS
cord-302047-vv5gpldi	330	6	into	into	IN
cord-302047-vv5gpldi	330	7	the	the	DT
cord-302047-vv5gpldi	330	8	V3	V3	NNP
cord-302047-vv5gpldi	330	9	region	region	NN
cord-302047-vv5gpldi	330	10	showed	show	VBD
cord-302047-vv5gpldi	330	11	lower	low	JJR
cord-302047-vv5gpldi	330	12	levels	level	NNS
cord-302047-vv5gpldi	330	13	of	of	IN
cord-302047-vv5gpldi	330	14	expression	expression	NN
cord-302047-vv5gpldi	330	15	(	(	-LRB-
cord-302047-vv5gpldi	330	16	Nakane	Nakane	NNP
cord-302047-vv5gpldi	330	17	,	,	,
cord-302047-vv5gpldi	330	18	Iwamoto	Iwamoto	NNP
cord-302047-vv5gpldi	330	19	,	,	,
cord-302047-vv5gpldi	330	20	and	and	CC
cord-302047-vv5gpldi	330	21	Matsuda	Matsuda	NNP
cord-302047-vv5gpldi	330	22	2015	2015	CD
cord-302047-vv5gpldi	330	23	)	)	-RRB-
cord-302047-vv5gpldi	330	24	,	,	,
cord-302047-vv5gpldi	330	25	which	which	WDT
cord-302047-vv5gpldi	330	26	is	be	VBZ
cord-302047-vv5gpldi	330	27	consistent	consistent	JJ
cord-302047-vv5gpldi	330	28	with	with	IN
cord-302047-vv5gpldi	330	29	V3	V3	NNP
cord-302047-vv5gpldi	330	30	having	have	VBG
cord-302047-vv5gpldi	330	31	the	the	DT
cord-302047-vv5gpldi	330	32	lowest	low	JJS
cord-302047-vv5gpldi	330	33	indel	indel	NN
cord-302047-vv5gpldi	330	34	rate	rate	NN
cord-302047-vv5gpldi	330	35	(	(	-LRB-
cord-302047-vv5gpldi	330	36	Palmer	Palmer	NNP
cord-302047-vv5gpldi	330	37	and	and	CC
cord-302047-vv5gpldi	330	38	Poon	Poon	NNP
cord-302047-vv5gpldi	330	39	2018	2018	CD
cord-302047-vv5gpldi	330	40	)	)	-RRB-
cord-302047-vv5gpldi	330	41	,	,	,
cord-302047-vv5gpldi	330	42	thus	thus	RB
cord-302047-vv5gpldi	330	43	having	have	VBG
cord-302047-vv5gpldi	330	44	a	a	DT
cord-302047-vv5gpldi	330	45	lower	low	JJR
cord-302047-vv5gpldi	330	46	stability	stability	NN
cord-302047-vv5gpldi	330	47	after	after	IN
cord-302047-vv5gpldi	330	48	gene	gene	NN
cord-302047-vv5gpldi	330	49	insertions	insertion	NNS
cord-302047-vv5gpldi	330	50	.	.	.
cord-302047-vv5gpldi	331	1	This	this	DT
cord-302047-vv5gpldi	331	2	piece	piece	NN
cord-302047-vv5gpldi	331	3	of	of	IN
cord-302047-vv5gpldi	331	4	empirical	empirical	JJ
cord-302047-vv5gpldi	331	5	evidence	evidence	NN
cord-302047-vv5gpldi	331	6	again	again	RB
cord-302047-vv5gpldi	331	7	shows	show	VBZ
cord-302047-vv5gpldi	331	8	that	that	IN
cord-302047-vv5gpldi	331	9	the	the	DT
cord-302047-vv5gpldi	331	10	site	site	NN
cord-302047-vv5gpldi	331	11	of	of	IN
cord-302047-vv5gpldi	331	12	insertion	insertion	NN
cord-302047-vv5gpldi	331	13	plays	play	VBZ
cord-302047-vv5gpldi	331	14	an	an	DT
cord-302047-vv5gpldi	331	15	important	important	JJ
cord-302047-vv5gpldi	331	16	role	role	NN
cord-302047-vv5gpldi	331	17	in	in	IN
cord-302047-vv5gpldi	331	18	determining	determine	VBG
cord-302047-vv5gpldi	331	19	expression	expression	NN
cord-302047-vv5gpldi	331	20	levels	level	NNS
cord-302047-vv5gpldi	331	21	and	and	CC
cord-302047-vv5gpldi	331	22	stability	stability	NN
cord-302047-vv5gpldi	331	23	.	.	.
cord-302047-vv5gpldi	332	1	Retroviruses	retrovirus	NNS
cord-302047-vv5gpldi	332	2	have	have	VBP
cord-302047-vv5gpldi	332	3	a	a	DT
cord-302047-vv5gpldi	332	4	valuable	valuable	JJ
cord-302047-vv5gpldi	332	5	potential	potential	NN
cord-302047-vv5gpldi	332	6	as	as	IN
cord-302047-vv5gpldi	332	7	vectors	vector	NNS
cord-302047-vv5gpldi	332	8	for	for	IN
cord-302047-vv5gpldi	332	9	introducing	introduce	VBG
cord-302047-vv5gpldi	332	10	therapeutic	therapeutic	JJ
cord-302047-vv5gpldi	332	11	genes	gene	NNS
cord-302047-vv5gpldi	332	12	into	into	IN
cord-302047-vv5gpldi	332	13	cancer	cancer	NN
cord-302047-vv5gpldi	332	14	cells	cell	NNS
cord-302047-vv5gpldi	332	15	.	.	.
cord-302047-vv5gpldi	333	1	Murine	murine	JJ
cord-302047-vv5gpldi	333	2	retroviruses	retrovirus	NNS
cord-302047-vv5gpldi	333	3	are	be	VBP
cord-302047-vv5gpldi	333	4	the	the	DT
cord-302047-vv5gpldi	333	5	most	most	RBS
cord-302047-vv5gpldi	333	6	commonly	commonly	RB
cord-302047-vv5gpldi	333	7	used	use	VBN
cord-302047-vv5gpldi	333	8	vectors	vector	NNS
cord-302047-vv5gpldi	333	9	in	in	IN
cord-302047-vv5gpldi	333	10	clinical	clinical	JJ
cord-302047-vv5gpldi	333	11	trials	trial	NNS
cord-302047-vv5gpldi	333	12	today	today	NN
cord-302047-vv5gpldi	333	13	,	,	,
cord-302047-vv5gpldi	333	14	and	and	CC
cord-302047-vv5gpldi	333	15	seem	seem	VB
cord-302047-vv5gpldi	333	16	promising	promising	JJ
cord-302047-vv5gpldi	333	17	candidates	candidate	NNS
cord-302047-vv5gpldi	333	18	for	for	IN
cord-302047-vv5gpldi	333	19	human	human	JJ
cord-302047-vv5gpldi	333	20	gene	gene	NN
cord-302047-vv5gpldi	333	21	therapy	therapy	NN
cord-302047-vv5gpldi	333	22	as	as	IN
cord-302047-vv5gpldi	333	23	they	-PRON-	PRP
cord-302047-vv5gpldi	333	24	target	target	VBP
cord-302047-vv5gpldi	333	25	dividing	divide	VBG
cord-302047-vv5gpldi	333	26	cells	cell	NNS
cord-302047-vv5gpldi	333	27	with	with	IN
cord-302047-vv5gpldi	333	28	a	a	DT
cord-302047-vv5gpldi	333	29	high	high	JJ
cord-302047-vv5gpldi	333	30	degree	degree	NN
cord-302047-vv5gpldi	333	31	of	of	IN
cord-302047-vv5gpldi	333	32	efficiency	efficiency	NN
cord-302047-vv5gpldi	333	33	and	and	CC
cord-302047-vv5gpldi	333	34	lead	lead	VB
cord-302047-vv5gpldi	333	35	to	to	IN
cord-302047-vv5gpldi	333	36	stable	stable	JJ
cord-302047-vv5gpldi	333	37	gene	gene	NN
cord-302047-vv5gpldi	333	38	transfer	transfer	NN
cord-302047-vv5gpldi	333	39	as	as	IN
cord-302047-vv5gpldi	333	40	they	-PRON-	PRP
cord-302047-vv5gpldi	333	41	integrate	integrate	VBP
cord-302047-vv5gpldi	333	42	into	into	IN
cord-302047-vv5gpldi	333	43	the	the	DT
cord-302047-vv5gpldi	333	44	chromosomes	chromosome	NNS
cord-302047-vv5gpldi	333	45	of	of	IN
cord-302047-vv5gpldi	333	46	the	the	DT
cord-302047-vv5gpldi	333	47	target	target	NN
cord-302047-vv5gpldi	333	48	cell	cell	NN
cord-302047-vv5gpldi	333	49	(	(	-LRB-
cord-302047-vv5gpldi	333	50	Edelstein	Edelstein	NNP
cord-302047-vv5gpldi	333	51	et	et	NNP
cord-302047-vv5gpldi	333	52	al	al	NNP
cord-302047-vv5gpldi	333	53	.	.	.
cord-302047-vv5gpldi	333	54	2004	2004	CD
cord-302047-vv5gpldi	333	55	)	)	-RRB-
cord-302047-vv5gpldi	333	56	.	.	.
cord-302047-vv5gpldi	334	1	However	however	RB
cord-302047-vv5gpldi	334	2	,	,	,
cord-302047-vv5gpldi	334	3	we	-PRON-	PRP
cord-302047-vv5gpldi	334	4	still	still	RB
cord-302047-vv5gpldi	334	5	have	have	VBP
cord-302047-vv5gpldi	334	6	to	to	TO
cord-302047-vv5gpldi	334	7	deal	deal	VB
cord-302047-vv5gpldi	334	8	with	with	IN
cord-302047-vv5gpldi	334	9	important	important	JJ
cord-302047-vv5gpldi	334	10	safety	safety	NN
cord-302047-vv5gpldi	334	11	issues	issue	NNS
cord-302047-vv5gpldi	334	12	when	when	WRB
cord-302047-vv5gpldi	334	13	using	use	VBG
cord-302047-vv5gpldi	334	14	retroviruses	retrovirus	NNS
cord-302047-vv5gpldi	334	15	for	for	IN
cord-302047-vv5gpldi	334	16	gene	gene	NN
cord-302047-vv5gpldi	334	17	therapy	therapy	NN
cord-302047-vv5gpldi	334	18	.	.	.
cord-302047-vv5gpldi	335	1	The	the	DT
cord-302047-vv5gpldi	335	2	random	random	JJ
cord-302047-vv5gpldi	335	3	integration	integration	NN
cord-302047-vv5gpldi	335	4	of	of	IN
cord-302047-vv5gpldi	335	5	retroviruses	retrovirus	NNS
cord-302047-vv5gpldi	335	6	in	in	IN
cord-302047-vv5gpldi	335	7	the	the	DT
cord-302047-vv5gpldi	335	8	host	host	NN
cord-302047-vv5gpldi	335	9	genome	genome	NN
cord-302047-vv5gpldi	335	10	poses	pose	VBZ
cord-302047-vv5gpldi	335	11	a	a	DT
cord-302047-vv5gpldi	335	12	risk	risk	NN
cord-302047-vv5gpldi	335	13	,	,	,
cord-302047-vv5gpldi	335	14	as	as	IN
cord-302047-vv5gpldi	335	15	the	the	DT
cord-302047-vv5gpldi	335	16	integration	integration	NN
cord-302047-vv5gpldi	335	17	near	near	IN
cord-302047-vv5gpldi	335	18	the	the	DT
cord-302047-vv5gpldi	335	19	LMO2	LMO2	NNP
cord-302047-vv5gpldi	335	20	proto	proto	JJ
cord-302047-vv5gpldi	335	21	-	-	HYPH
cord-302047-vv5gpldi	335	22	oncogene	oncogene	NN
cord-302047-vv5gpldi	335	23	promoter	promoter	NN
cord-302047-vv5gpldi	335	24	can	can	MD
cord-302047-vv5gpldi	335	25	trigger	trigger	VB
cord-302047-vv5gpldi	335	26	the	the	DT
cord-302047-vv5gpldi	335	27	development	development	NN
cord-302047-vv5gpldi	335	28	of	of	IN
cord-302047-vv5gpldi	335	29	leukemia	leukemia	NN
cord-302047-vv5gpldi	335	30	(	(	-LRB-
cord-302047-vv5gpldi	335	31	Hacein	Hacein	NNP
cord-302047-vv5gpldi	335	32	-	-	HYPH
cord-302047-vv5gpldi	335	33	Bey	Bey	NNP
cord-302047-vv5gpldi	335	34	-	-	HYPH
cord-302047-vv5gpldi	335	35	Abina	Abina	NNP
cord-302047-vv5gpldi	335	36	et	et	NNP
cord-302047-vv5gpldi	335	37	al	al	NNP
cord-302047-vv5gpldi	335	38	.	.	NNP
cord-302047-vv5gpldi	335	39	2003	2003	CD
cord-302047-vv5gpldi	335	40	)	)	-RRB-
cord-302047-vv5gpldi	335	41	.	.	.
cord-302047-vv5gpldi	336	1	Besides	besides	IN
cord-302047-vv5gpldi	336	2	the	the	DT
cord-302047-vv5gpldi	336	3	risks	risk	NNS
cord-302047-vv5gpldi	336	4	related	relate	VBN
cord-302047-vv5gpldi	336	5	to	to	IN
cord-302047-vv5gpldi	336	6	retroviral	retroviral	JJ
cord-302047-vv5gpldi	336	7	gene	gene	NN
cord-302047-vv5gpldi	336	8	therapy	therapy	NN
cord-302047-vv5gpldi	336	9	,	,	,
cord-302047-vv5gpldi	336	10	the	the	DT
cord-302047-vv5gpldi	336	11	limited	limited	JJ
cord-302047-vv5gpldi	336	12	efficiency	efficiency	NN
cord-302047-vv5gpldi	336	13	of	of	IN
cord-302047-vv5gpldi	336	14	in	in	IN
cord-302047-vv5gpldi	336	15	vivo	vivo	NN
cord-302047-vv5gpldi	336	16	gene	gene	NN
cord-302047-vv5gpldi	336	17	transfer	transfer	NN
cord-302047-vv5gpldi	336	18	poses	pose	VBZ
cord-302047-vv5gpldi	336	19	another	another	DT
cord-302047-vv5gpldi	336	20	obstacle	obstacle	NN
cord-302047-vv5gpldi	336	21	.	.	.
cord-302047-vv5gpldi	337	1	Replication	replication	NN
cord-302047-vv5gpldi	337	2	defective	defective	JJ
cord-302047-vv5gpldi	337	3	retrovirus	retrovirus	NN
cord-302047-vv5gpldi	337	4	vectors	vector	NNS
cord-302047-vv5gpldi	337	5	are	be	VBP
cord-302047-vv5gpldi	337	6	often	often	RB
cord-302047-vv5gpldi	337	7	used	use	VBN
cord-302047-vv5gpldi	337	8	in	in	IN
cord-302047-vv5gpldi	337	9	clinical	clinical	JJ
cord-302047-vv5gpldi	337	10	trials	trial	NNS
cord-302047-vv5gpldi	337	11	but	but	CC
cord-302047-vv5gpldi	337	12	limited	limited	JJ
cord-302047-vv5gpldi	337	13	since	since	IN
cord-302047-vv5gpldi	337	14	they	-PRON-	PRP
cord-302047-vv5gpldi	337	15	can	can	MD
cord-302047-vv5gpldi	337	16	only	only	RB
cord-302047-vv5gpldi	337	17	infect	infect	VB
cord-302047-vv5gpldi	337	18	a	a	DT
cord-302047-vv5gpldi	337	19	fraction	fraction	NN
cord-302047-vv5gpldi	337	20	of	of	IN
cord-302047-vv5gpldi	337	21	solid	solid	JJ
cord-302047-vv5gpldi	337	22	tumor	tumor	NN
cord-302047-vv5gpldi	337	23	cells	cell	NNS
cord-302047-vv5gpldi	337	24	(	(	-LRB-
cord-302047-vv5gpldi	337	25	Rainov	Rainov	NNP
cord-302047-vv5gpldi	337	26	and	and	CC
cord-302047-vv5gpldi	337	27	Ren	Ren	NNP
cord-302047-vv5gpldi	337	28	2003	2003	CD
cord-302047-vv5gpldi	337	29	)	)	-RRB-
cord-302047-vv5gpldi	337	30	.	.	.
cord-302047-vv5gpldi	338	1	For	for	IN
cord-302047-vv5gpldi	338	2	the	the	DT
cord-302047-vv5gpldi	338	3	delivery	delivery	NN
cord-302047-vv5gpldi	338	4	of	of	IN
cord-302047-vv5gpldi	338	5	the	the	DT
cord-302047-vv5gpldi	338	6	transgene	transgene	NN
cord-302047-vv5gpldi	338	7	in	in	IN
cord-302047-vv5gpldi	338	8	all	all	DT
cord-302047-vv5gpldi	338	9	tumor	tumor	NN
cord-302047-vv5gpldi	338	10	cells	cell	NNS
cord-302047-vv5gpldi	338	11	,	,	,
cord-302047-vv5gpldi	338	12	replication	replication	NN
cord-302047-vv5gpldi	338	13	-	-	HYPH
cord-302047-vv5gpldi	338	14	competent	competent	JJ
cord-302047-vv5gpldi	338	15	retroviral	retroviral	JJ
cord-302047-vv5gpldi	338	16	vectors	vector	NNS
cord-302047-vv5gpldi	338	17	are	be	VBP
cord-302047-vv5gpldi	338	18	a	a	DT
cord-302047-vv5gpldi	338	19	promising	promising	JJ
cord-302047-vv5gpldi	338	20	alternative	alternative	NN
cord-302047-vv5gpldi	338	21	.	.	.
cord-302047-vv5gpldi	339	1	The	the	DT
cord-302047-vv5gpldi	339	2	suitability	suitability	NN
cord-302047-vv5gpldi	339	3	of	of	IN
cord-302047-vv5gpldi	339	4	murine	murine	JJ
cord-302047-vv5gpldi	339	5	leukemia	leukemia	NN
cord-302047-vv5gpldi	339	6	virus	virus	NN
cord-302047-vv5gpldi	339	7	(	(	-LRB-
cord-302047-vv5gpldi	339	8	MLV)-based	mlv)-base	VBN
cord-302047-vv5gpldi	339	9	vectors	vector	NNS
cord-302047-vv5gpldi	339	10	for	for	IN
cord-302047-vv5gpldi	339	11	cancer	cancer	NN
cord-302047-vv5gpldi	339	12	gene	gene	NN
cord-302047-vv5gpldi	339	13	therapy	therapy	NN
cord-302047-vv5gpldi	339	14	has	have	VBZ
cord-302047-vv5gpldi	339	15	been	be	VBN
cord-302047-vv5gpldi	339	16	analyzed	analyze	VBN
cord-302047-vv5gpldi	339	17	in	in	IN
cord-302047-vv5gpldi	339	18	vitro	vitro	FW
cord-302047-vv5gpldi	339	19	and	and	CC
cord-302047-vv5gpldi	339	20	in	in	IN
cord-302047-vv5gpldi	339	21	vivo	vivo	NN
cord-302047-vv5gpldi	339	22	by	by	IN
cord-302047-vv5gpldi	339	23	Paar	Paar	NNP
cord-302047-vv5gpldi	339	24	et	et	FW
cord-302047-vv5gpldi	339	25	al	al	NNP
cord-302047-vv5gpldi	339	26	.	.	.
cord-302047-vv5gpldi	340	1	(	(	-LRB-
cord-302047-vv5gpldi	340	2	2007	2007	CD
cord-302047-vv5gpldi	340	3	)	)	-RRB-
cord-302047-vv5gpldi	340	4	.	.	.
cord-302047-vv5gpldi	341	1	They	-PRON-	PRP
cord-302047-vv5gpldi	341	2	found	find	VBD
cord-302047-vv5gpldi	341	3	that	that	IN
cord-302047-vv5gpldi	341	4	the	the	DT
cord-302047-vv5gpldi	341	5	choice	choice	NN
cord-302047-vv5gpldi	341	6	of	of	IN
cord-302047-vv5gpldi	341	7	the	the	DT
cord-302047-vv5gpldi	341	8	virus	virus	NN
cord-302047-vv5gpldi	341	9	strain	strain	NN
cord-302047-vv5gpldi	341	10	,	,	,
cord-302047-vv5gpldi	341	11	the	the	DT
cord-302047-vv5gpldi	341	12	position	position	NN
cord-302047-vv5gpldi	341	13	of	of	IN
cord-302047-vv5gpldi	341	14	the	the	DT
cord-302047-vv5gpldi	341	15	insert	insert	NN
cord-302047-vv5gpldi	341	16	,	,	,
cord-302047-vv5gpldi	341	17	and	and	CC
cord-302047-vv5gpldi	341	18	the	the	DT
cord-302047-vv5gpldi	341	19	host	host	NN
cord-302047-vv5gpldi	341	20	cells	cell	NNS
cord-302047-vv5gpldi	341	21	used	use	VBN
cord-302047-vv5gpldi	341	22	,	,	,
cord-302047-vv5gpldi	341	23	can	can	MD
cord-302047-vv5gpldi	341	24	influence	influence	VB
cord-302047-vv5gpldi	341	25	the	the	DT
cord-302047-vv5gpldi	341	26	replication	replication	NN
cord-302047-vv5gpldi	341	27	kinetics	kinetic	NNS
cord-302047-vv5gpldi	341	28	,	,	,
cord-302047-vv5gpldi	341	29	genomic	genomic	JJ
cord-302047-vv5gpldi	341	30	stability	stability	NN
cord-302047-vv5gpldi	341	31	,	,	,
cord-302047-vv5gpldi	341	32	and	and	CC
cord-302047-vv5gpldi	341	33	transgene	transgene	JJ
cord-302047-vv5gpldi	341	34	expression	expression	NN
cord-302047-vv5gpldi	341	35	levels	level	NNS
cord-302047-vv5gpldi	341	36	(	(	-LRB-
cord-302047-vv5gpldi	341	37	Paar	Paar	NNP
cord-302047-vv5gpldi	341	38	et	et	FW
cord-302047-vv5gpldi	341	39	al	al	NNP
cord-302047-vv5gpldi	341	40	.	.	NNP
cord-302047-vv5gpldi	341	41	2007	2007	CD
cord-302047-vv5gpldi	341	42	)	)	-RRB-
cord-302047-vv5gpldi	341	43	.	.	.
cord-302047-vv5gpldi	342	1	Concordantly	concordantly	RB
cord-302047-vv5gpldi	342	2	,	,	,
cord-302047-vv5gpldi	342	3	the	the	DT
cord-302047-vv5gpldi	342	4	eGFP	eGFP	NNP
cord-302047-vv5gpldi	342	5	sequence	sequence	NN
cord-302047-vv5gpldi	342	6	was	be	VBD
cord-302047-vv5gpldi	342	7	inserted	insert	VBN
cord-302047-vv5gpldi	342	8	into	into	IN
cord-302047-vv5gpldi	342	9	MLV	MLV	NNP
cord-302047-vv5gpldi	342	10	under	under	IN
cord-302047-vv5gpldi	342	11	different	different	JJ
cord-302047-vv5gpldi	342	12	configurations	configuration	NNS
cord-302047-vv5gpldi	342	13	(	(	-LRB-
cord-302047-vv5gpldi	342	14	i.e.	i.e.	FW
cord-302047-vv5gpldi	342	15	site	site	NN
cord-302047-vv5gpldi	342	16	of	of	IN
cord-302047-vv5gpldi	342	17	insertion	insertion	NN
cord-302047-vv5gpldi	342	18	and	and	CC
cord-302047-vv5gpldi	342	19	flanking	flanking	JJ
cord-302047-vv5gpldi	342	20	sequence	sequence	NN
cord-302047-vv5gpldi	342	21	)	)	-RRB-
cord-302047-vv5gpldi	342	22	,	,	,
cord-302047-vv5gpldi	342	23	and	and	CC
cord-302047-vv5gpldi	342	24	the	the	DT
cord-302047-vv5gpldi	342	25	reporter	reporter	NN
cord-302047-vv5gpldi	342	26	gene	gene	NN
cord-302047-vv5gpldi	342	27	was	be	VBD
cord-302047-vv5gpldi	342	28	deleted	delete	VBN
cord-302047-vv5gpldi	342	29	upon	upon	IN
cord-302047-vv5gpldi	342	30	extended	extended	JJ
cord-302047-vv5gpldi	342	31	cell	cell	NN
cord-302047-vv5gpldi	342	32	culture	culture	NN
cord-302047-vv5gpldi	342	33	(	(	-LRB-
cord-302047-vv5gpldi	342	34	Duch	Duch	NNP
cord-302047-vv5gpldi	342	35	et	et	FW
cord-302047-vv5gpldi	342	36	al	al	NNP
cord-302047-vv5gpldi	342	37	.	.	.
cord-302047-vv5gpldi	342	38	2004	2004	CD
cord-302047-vv5gpldi	342	39	)	)	-RRB-
cord-302047-vv5gpldi	342	40	.	.	.
cord-302047-vv5gpldi	343	1	The	the	DT
cord-302047-vv5gpldi	343	2	stability	stability	NN
cord-302047-vv5gpldi	343	3	was	be	VBD
cord-302047-vv5gpldi	343	4	improved	improve	VBN
cord-302047-vv5gpldi	343	5	by	by	IN
cord-302047-vv5gpldi	343	6	decreasing	decrease	VBG
cord-302047-vv5gpldi	343	7	the	the	DT
cord-302047-vv5gpldi	343	8	length	length	NN
cord-302047-vv5gpldi	343	9	of	of	IN
cord-302047-vv5gpldi	343	10	sequence	sequence	NN
cord-302047-vv5gpldi	343	11	repeats	repeat	VBZ
cord-302047-vv5gpldi	343	12	flanking	flank	VBG
cord-302047-vv5gpldi	343	13	the	the	DT
cord-302047-vv5gpldi	343	14	inserted	insert	VBN
cord-302047-vv5gpldi	343	15	sequence	sequence	NN
cord-302047-vv5gpldi	343	16	,	,	,
cord-302047-vv5gpldi	343	17	however	however	RB
cord-302047-vv5gpldi	343	18	,	,	,
cord-302047-vv5gpldi	344	1	eventually	eventually	RB
cord-302047-vv5gpldi	344	2	eGFP	eGFP	NNP
cord-302047-vv5gpldi	344	3	was	be	VBD
cord-302047-vv5gpldi	344	4	always	always	RB
cord-302047-vv5gpldi	344	5	(	(	-LRB-
cord-302047-vv5gpldi	344	6	partially	partially	RB
cord-302047-vv5gpldi	344	7	or	or	CC
cord-302047-vv5gpldi	344	8	completely	completely	RB
cord-302047-vv5gpldi	344	9	)	)	-RRB-
cord-302047-vv5gpldi	344	10	deleted	delete	VBN
cord-302047-vv5gpldi	345	1	(	(	-LRB-
cord-302047-vv5gpldi	345	2	Duch	Duch	NNP
cord-302047-vv5gpldi	345	3	et	et	FW
cord-302047-vv5gpldi	345	4	al	al	NNP
cord-302047-vv5gpldi	345	5	.	.	.
cord-302047-vv5gpldi	345	6	2004	2004	CD
cord-302047-vv5gpldi	345	7	)	)	-RRB-
cord-302047-vv5gpldi	345	8	.	.	.
cord-302047-vv5gpldi	346	1	In	in	IN
cord-302047-vv5gpldi	346	2	another	another	DT
cord-302047-vv5gpldi	346	3	study	study	NN
cord-302047-vv5gpldi	346	4	,	,	,
cord-302047-vv5gpldi	346	5	transgenes	transgene	NNS
cord-302047-vv5gpldi	346	6	of	of	IN
cord-302047-vv5gpldi	346	7	different	different	JJ
cord-302047-vv5gpldi	346	8	sizes	size	NNS
cord-302047-vv5gpldi	346	9	(	(	-LRB-
cord-302047-vv5gpldi	346	10	GFP	GFP	NNP
cord-302047-vv5gpldi	346	11	,	,	,
cord-302047-vv5gpldi	346	12	hph	hph	NNP
cord-302047-vv5gpldi	346	13	,	,	,
cord-302047-vv5gpldi	346	14	pac	pac	NNP
cord-302047-vv5gpldi	346	15	)	)	-RRB-
cord-302047-vv5gpldi	346	16	were	be	VBD
cord-302047-vv5gpldi	346	17	inserted	insert	VBN
cord-302047-vv5gpldi	346	18	into	into	IN
cord-302047-vv5gpldi	346	19	MLV	MLV	NNP
cord-302047-vv5gpldi	346	20	.	.	.
cord-302047-vv5gpldi	347	1	Deletions	deletion	NNS
cord-302047-vv5gpldi	347	2	were	be	VBD
cord-302047-vv5gpldi	347	3	always	always	RB
cord-302047-vv5gpldi	347	4	observed	observe	VBN
cord-302047-vv5gpldi	347	5	,	,	,
cord-302047-vv5gpldi	347	6	where	where	WRB
cord-302047-vv5gpldi	347	7	the	the	DT
cord-302047-vv5gpldi	347	8	deletion	deletion	NN
cord-302047-vv5gpldi	347	9	dynamics	dynamic	NNS
cord-302047-vv5gpldi	347	10	depended	depend	VBD
cord-302047-vv5gpldi	347	11	on	on	IN
cord-302047-vv5gpldi	347	12	the	the	DT
cord-302047-vv5gpldi	347	13	size	size	NN
cord-302047-vv5gpldi	347	14	of	of	IN
cord-302047-vv5gpldi	347	15	the	the	DT
cord-302047-vv5gpldi	347	16	insert	insert	JJ
cord-302047-vv5gpldi	347	17	and	and	CC
cord-302047-vv5gpldi	347	18	preferred	preferred	JJ
cord-302047-vv5gpldi	347	19	sites	site	NNS
cord-302047-vv5gpldi	347	20	of	of	IN
cord-302047-vv5gpldi	347	21	recombination	recombination	NN
cord-302047-vv5gpldi	347	22	were	be	VBD
cord-302047-vv5gpldi	347	23	detected	detect	VBN
cord-302047-vv5gpldi	348	1	(	(	-LRB-
cord-302047-vv5gpldi	348	2	Logg	Logg	NNP
cord-302047-vv5gpldi	348	3	et	et	NNP
cord-302047-vv5gpldi	348	4	al	al	NNP
cord-302047-vv5gpldi	348	5	.	.	NNP
cord-302047-vv5gpldi	348	6	2001	2001	CD
cord-302047-vv5gpldi	348	7	)	)	-RRB-
cord-302047-vv5gpldi	348	8	.	.	.
cord-302047-vv5gpldi	349	1	Using	use	VBG
cord-302047-vv5gpldi	349	2	retroviral	retroviral	NN
cord-302047-vv5gpldi	349	3	vectors	vector	NNS
cord-302047-vv5gpldi	349	4	for	for	IN
cord-302047-vv5gpldi	349	5	the	the	DT
cord-302047-vv5gpldi	349	6	expression	expression	NN
cord-302047-vv5gpldi	349	7	and	and	CC
cord-302047-vv5gpldi	349	8	transfer	transfer	NN
cord-302047-vv5gpldi	349	9	of	of	IN
cord-302047-vv5gpldi	349	10	foreign	foreign	JJ
cord-302047-vv5gpldi	349	11	genes	gene	NNS
cord-302047-vv5gpldi	349	12	is	be	VBZ
cord-302047-vv5gpldi	349	13	central	central	JJ
cord-302047-vv5gpldi	349	14	to	to	IN
cord-302047-vv5gpldi	349	15	the	the	DT
cord-302047-vv5gpldi	349	16	development	development	NN
cord-302047-vv5gpldi	349	17	of	of	IN
cord-302047-vv5gpldi	349	18	gene	gene	NN
cord-302047-vv5gpldi	349	19	therapy	therapy	NN
cord-302047-vv5gpldi	349	20	.	.	.
cord-302047-vv5gpldi	350	1	An	an	DT
cord-302047-vv5gpldi	350	2	advantage	advantage	NN
cord-302047-vv5gpldi	350	3	of	of	IN
cord-302047-vv5gpldi	350	4	using	use	VBG
cord-302047-vv5gpldi	350	5	retro	retro	NNP
cord-302047-vv5gpldi	350	6	-	-	HYPH
cord-302047-vv5gpldi	350	7	transcribing	transcribe	VBG
cord-302047-vv5gpldi	350	8	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	350	9	)	)	-RRB-
cord-302047-vv5gpldi	350	10	viruses	virus	NNS
cord-302047-vv5gpldi	350	11	is	be	VBZ
cord-302047-vv5gpldi	350	12	that	that	IN
cord-302047-vv5gpldi	350	13	after	after	IN
cord-302047-vv5gpldi	350	14	reverse	reverse	NN
cord-302047-vv5gpldi	350	15	transcription	transcription	NN
cord-302047-vv5gpldi	350	16	a	a	DT
cord-302047-vv5gpldi	350	17	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	350	18	molecule	molecule	NN
cord-302047-vv5gpldi	350	19	stably	stably	RB
cord-302047-vv5gpldi	350	20	integrates	integrate	VBZ
cord-302047-vv5gpldi	350	21	into	into	IN
cord-302047-vv5gpldi	350	22	the	the	DT
cord-302047-vv5gpldi	350	23	host	host	NN
cord-302047-vv5gpldi	350	24	genome	genome	NN
cord-302047-vv5gpldi	350	25	.	.	.
cord-302047-vv5gpldi	351	1	With	with	IN
cord-302047-vv5gpldi	351	2	careful	careful	JJ
cord-302047-vv5gpldi	351	3	design	design	NN
cord-302047-vv5gpldi	351	4	,	,	,
cord-302047-vv5gpldi	351	5	testing	testing	NN
cord-302047-vv5gpldi	351	6	,	,	,
cord-302047-vv5gpldi	351	7	and	and	CC
cord-302047-vv5gpldi	351	8	engineering	engineering	NN
cord-302047-vv5gpldi	351	9	,	,	,
cord-302047-vv5gpldi	351	10	the	the	DT
cord-302047-vv5gpldi	351	11	retroviruses	retrovirus	NNS
cord-302047-vv5gpldi	351	12	are	be	VBP
cord-302047-vv5gpldi	351	13	promising	promising	JJ
cord-302047-vv5gpldi	351	14	vectors	vector	NNS
cord-302047-vv5gpldi	351	15	for	for	IN
cord-302047-vv5gpldi	351	16	the	the	DT
cord-302047-vv5gpldi	351	17	treatment	treatment	NN
cord-302047-vv5gpldi	351	18	of	of	IN
cord-302047-vv5gpldi	351	19	diseases	disease	NNS
cord-302047-vv5gpldi	351	20	,	,	,
cord-302047-vv5gpldi	351	21	such	such	JJ
cord-302047-vv5gpldi	351	22	as	as	IN
cord-302047-vv5gpldi	351	23	cancer	cancer	NN
cord-302047-vv5gpldi	351	24	.	.	.
cord-302047-vv5gpldi	352	1	The	the	DT
cord-302047-vv5gpldi	352	2	retro	retro	NN
cord-302047-vv5gpldi	352	3	-	-	HYPH
cord-302047-vv5gpldi	352	4	transcribing	transcribe	VBG
cord-302047-vv5gpldi	352	5	dsDNA	dsdna	RB
cord-302047-vv5gpldi	353	1	(	(	-LRB-
cord-302047-vv5gpldi	353	2	RT	RT	NNP
cord-302047-vv5gpldi	353	3	-	-	HYPH
cord-302047-vv5gpldi	353	4	dsDNA	dsDNA	NNP
cord-302047-vv5gpldi	353	5	)	)	-RRB-
cord-302047-vv5gpldi	353	6	viruses	virus	NNS
cord-302047-vv5gpldi	353	7	have	have	VBP
cord-302047-vv5gpldi	353	8	small	small	JJ
cord-302047-vv5gpldi	353	9	genome	genome	NN
cord-302047-vv5gpldi	353	10	sizes	size	NNS
cord-302047-vv5gpldi	353	11	varying	vary	VBG
cord-302047-vv5gpldi	353	12	from	from	IN
cord-302047-vv5gpldi	353	13	3	3	CD
cord-302047-vv5gpldi	353	14	to	to	IN
cord-302047-vv5gpldi	353	15	8.3	8.3	CD
cord-302047-vv5gpldi	353	16	kb	kb	NNP
cord-302047-vv5gpldi	353	17	,	,	,
cord-302047-vv5gpldi	353	18	and	and	CC
cord-302047-vv5gpldi	353	19	include	include	VBP
cord-302047-vv5gpldi	353	20	the	the	DT
cord-302047-vv5gpldi	353	21	viral	viral	JJ
cord-302047-vv5gpldi	353	22	families	family	NNS
cord-302047-vv5gpldi	353	23	Caulimoviridae	Caulimoviridae	NNP
cord-302047-vv5gpldi	353	24	and	and	CC
cord-302047-vv5gpldi	353	25	Hepadnaviridae	Hepadnaviridae	NNP
cord-302047-vv5gpldi	353	26	.	.	.
cord-302047-vv5gpldi	354	1	As	as	IN
cord-302047-vv5gpldi	354	2	the	the	DT
cord-302047-vv5gpldi	354	3	name	name	NN
cord-302047-vv5gpldi	354	4	suggests	suggest	VBZ
cord-302047-vv5gpldi	354	5	,	,	,
cord-302047-vv5gpldi	354	6	the	the	DT
cord-302047-vv5gpldi	354	7	RT	RT	NNP
cord-302047-vv5gpldi	354	8	-	-	HYPH
cord-302047-vv5gpldi	354	9	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	354	10	viruses	virus	NNS
cord-302047-vv5gpldi	354	11	replicate	replicate	VBP
cord-302047-vv5gpldi	354	12	through	through	IN
cord-302047-vv5gpldi	354	13	an	an	DT
cord-302047-vv5gpldi	354	14	RNA	RNA	NNP
cord-302047-vv5gpldi	354	15	intermediate	intermediate	NN
cord-302047-vv5gpldi	354	16	,	,	,
cord-302047-vv5gpldi	354	17	and	and	CC
cord-302047-vv5gpldi	354	18	in	in	IN
cord-302047-vv5gpldi	354	19	some	some	DT
cord-302047-vv5gpldi	354	20	cases	case	NNS
cord-302047-vv5gpldi	354	21	the	the	DT
cord-302047-vv5gpldi	354	22	pre	pre	JJ
cord-302047-vv5gpldi	354	23	-	-	JJ
cord-302047-vv5gpldi	354	24	genomic	genomic	JJ
cord-302047-vv5gpldi	354	25	RNA	RNA	NNP
cord-302047-vv5gpldi	354	26	is	be	VBZ
cord-302047-vv5gpldi	354	27	alternatively	alternatively	RB
cord-302047-vv5gpldi	354	28	spliced	splice	VBN
cord-302047-vv5gpldi	354	29	.	.	.
cord-302047-vv5gpldi	355	1	Although	although	IN
cord-302047-vv5gpldi	355	2	genomic	genomic	JJ
cord-302047-vv5gpldi	355	3	rearrangements	rearrangement	NNS
cord-302047-vv5gpldi	355	4	appear	appear	VBP
cord-302047-vv5gpldi	355	5	to	to	TO
cord-302047-vv5gpldi	355	6	be	be	VB
cord-302047-vv5gpldi	355	7	frequent	frequent	JJ
cord-302047-vv5gpldi	355	8	in	in	IN
cord-302047-vv5gpldi	355	9	RT	RT	NNP
cord-302047-vv5gpldi	355	10	-	-	HYPH
cord-302047-vv5gpldi	355	11	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	355	12	viruses	virus	NNS
cord-302047-vv5gpldi	355	13	,	,	,
cord-302047-vv5gpldi	355	14	we	-PRON-	PRP
cord-302047-vv5gpldi	355	15	hypothesize	hypothesize	VBP
cord-302047-vv5gpldi	355	16	that	that	IN
cord-302047-vv5gpldi	355	17	gene	gene	NN
cord-302047-vv5gpldi	355	18	insertions	insertion	NNS
cord-302047-vv5gpldi	355	19	will	will	MD
cord-302047-vv5gpldi	355	20	often	often	RB
cord-302047-vv5gpldi	355	21	be	be	VB
cord-302047-vv5gpldi	355	22	unstable	unstable	JJ
cord-302047-vv5gpldi	355	23	,	,	,
cord-302047-vv5gpldi	355	24	because	because	IN
cord-302047-vv5gpldi	355	25	1	1	CD
cord-302047-vv5gpldi	355	26	,	,	,
cord-302047-vv5gpldi	355	27	they	-PRON-	PRP
cord-302047-vv5gpldi	355	28	tend	tend	VBP
cord-302047-vv5gpldi	355	29	to	to	TO
cord-302047-vv5gpldi	355	30	have	have	VB
cord-302047-vv5gpldi	355	31	compact	compact	JJ
cord-302047-vv5gpldi	355	32	genomes	genome	NNS
cord-302047-vv5gpldi	355	33	,	,	,
cord-302047-vv5gpldi	355	34	and	and	CC
cord-302047-vv5gpldi	355	35	2	2	CD
cord-302047-vv5gpldi	355	36	,	,	,
cord-302047-vv5gpldi	355	37	insertions	insertion	NNS
cord-302047-vv5gpldi	355	38	can	can	MD
cord-302047-vv5gpldi	355	39	easily	easily	RB
cord-302047-vv5gpldi	355	40	disturb	disturb	VB
cord-302047-vv5gpldi	355	41	a	a	DT
cord-302047-vv5gpldi	355	42	viral	viral	JJ
cord-302047-vv5gpldi	355	43	regulatory	regulatory	JJ
cord-302047-vv5gpldi	355	44	sequence	sequence	NN
cord-302047-vv5gpldi	355	45	or	or	CC
cord-302047-vv5gpldi	355	46	lead	lead	VB
cord-302047-vv5gpldi	355	47	to	to	IN
cord-302047-vv5gpldi	355	48	incorrect	incorrect	JJ
cord-302047-vv5gpldi	355	49	processing	processing	NN
cord-302047-vv5gpldi	355	50	of	of	IN
cord-302047-vv5gpldi	355	51	the	the	DT
cord-302047-vv5gpldi	355	52	alternative	alternative	JJ
cord-302047-vv5gpldi	355	53	spliced	splice	VBN
cord-302047-vv5gpldi	355	54	products	product	NNS
cord-302047-vv5gpldi	355	55	.	.	.
cord-302047-vv5gpldi	356	1	A.	A.	NNP
cord-302047-vv5gpldi	356	2	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	356	3	and	and	CC
cord-302047-vv5gpldi	356	4	M.	M.	NNP
cord-302047-vv5gpldi	356	5	P.	P.	NNP
cord-302047-vv5gpldi	356	6	Zwart	Zwart	NNP
cord-302047-vv5gpldi	357	1	|	|	NNP
cord-302047-vv5gpldi	357	2	9	9	CD
cord-302047-vv5gpldi	357	3	2.7.1	2.7.1	CD
cord-302047-vv5gpldi	357	4	Wild	wild	JJ
cord-302047-vv5gpldi	357	5	viruses	virus	NNS
cord-302047-vv5gpldi	358	1	In	in	IN
cord-302047-vv5gpldi	358	2	contrast	contrast	NN
cord-302047-vv5gpldi	358	3	to	to	IN
cord-302047-vv5gpldi	358	4	the	the	DT
cord-302047-vv5gpldi	358	5	retroviruses	retrovirus	NNS
cord-302047-vv5gpldi	358	6	(	(	-LRB-
cord-302047-vv5gpldi	358	7	group	group	NN
cord-302047-vv5gpldi	358	8	VI	VI	NNP
cord-302047-vv5gpldi	358	9	)	)	-RRB-
cord-302047-vv5gpldi	358	10	,	,	,
cord-302047-vv5gpldi	358	11	the	the	DT
cord-302047-vv5gpldi	358	12	genome	genome	NN
cord-302047-vv5gpldi	358	13	replication	replication	NN
cord-302047-vv5gpldi	358	14	of	of	IN
cord-302047-vv5gpldi	358	15	the	the	DT
cord-302047-vv5gpldi	358	16	Caulimoviridae	Caulimoviridae	NNP
cord-302047-vv5gpldi	358	17	is	be	VBZ
cord-302047-vv5gpldi	358	18	entirely	entirely	RB
cord-302047-vv5gpldi	358	19	episomal	episomal	JJ
cord-302047-vv5gpldi	358	20	.	.	.
cord-302047-vv5gpldi	359	1	However	however	RB
cord-302047-vv5gpldi	359	2	,	,	,
cord-302047-vv5gpldi	359	3	fragmented	fragmented	JJ
cord-302047-vv5gpldi	359	4	and	and	CC
cord-302047-vv5gpldi	359	5	rearranged	rearrange	VBD
cord-302047-vv5gpldi	359	6	endogenous	endogenous	JJ
cord-302047-vv5gpldi	359	7	caulimovirus	caulimovirus	NN
cord-302047-vv5gpldi	359	8	sequences	sequence	NNS
cord-302047-vv5gpldi	359	9	have	have	VBP
cord-302047-vv5gpldi	359	10	been	be	VBN
cord-302047-vv5gpldi	359	11	found	find	VBN
cord-302047-vv5gpldi	359	12	in	in	IN
cord-302047-vv5gpldi	359	13	a	a	DT
cord-302047-vv5gpldi	359	14	wide	wide	JJ
cord-302047-vv5gpldi	359	15	variety	variety	NN
cord-302047-vv5gpldi	359	16	of	of	IN
cord-302047-vv5gpldi	359	17	plant	plant	NN
cord-302047-vv5gpldi	359	18	species	specie	NNS
cord-302047-vv5gpldi	359	19	(	(	-LRB-
cord-302047-vv5gpldi	359	20	Teycheney	Teycheney	NNP
cord-302047-vv5gpldi	359	21	and	and	CC
cord-302047-vv5gpldi	359	22	Geering	Geering	NNP
cord-302047-vv5gpldi	359	23	2011	2011	CD
cord-302047-vv5gpldi	359	24	)	)	-RRB-
cord-302047-vv5gpldi	359	25	.	.	.
cord-302047-vv5gpldi	360	1	For	for	IN
cord-302047-vv5gpldi	360	2	the	the	DT
cord-302047-vv5gpldi	360	3	Hepadnaviridae	Hepadnaviridae	NNP
cord-302047-vv5gpldi	360	4	,	,	,
cord-302047-vv5gpldi	360	5	the	the	DT
cord-302047-vv5gpldi	360	6	viral	viral	JJ
cord-302047-vv5gpldi	360	7	genome	genome	NN
cord-302047-vv5gpldi	360	8	can	can	MD
cord-302047-vv5gpldi	360	9	be	be	VB
cord-302047-vv5gpldi	360	10	integrated	integrate	VBN
cord-302047-vv5gpldi	360	11	into	into	IN
cord-302047-vv5gpldi	360	12	the	the	DT
cord-302047-vv5gpldi	360	13	host	host	NN
cord-302047-vv5gpldi	360	14	genome	genome	NN
cord-302047-vv5gpldi	360	15	,	,	,
cord-302047-vv5gpldi	360	16	through	through	IN
cord-302047-vv5gpldi	360	17	a	a	DT
cord-302047-vv5gpldi	360	18	process	process	NN
cord-302047-vv5gpldi	360	19	that	that	WDT
cord-302047-vv5gpldi	360	20	exploits	exploit	VBZ
cord-302047-vv5gpldi	360	21	ds	ds	NNP
cord-302047-vv5gpldi	360	22	breaks	break	VBZ
cord-302047-vv5gpldi	360	23	in	in	IN
cord-302047-vv5gpldi	360	24	the	the	DT
cord-302047-vv5gpldi	360	25	host	host	NN
cord-302047-vv5gpldi	360	26	genome	genome	NN
cord-302047-vv5gpldi	360	27	.	.	.
cord-302047-vv5gpldi	361	1	Although	although	IN
cord-302047-vv5gpldi	361	2	this	this	DT
cord-302047-vv5gpldi	361	3	is	be	VBZ
cord-302047-vv5gpldi	361	4	an	an	DT
cord-302047-vv5gpldi	361	5	infrequent	infrequent	JJ
cord-302047-vv5gpldi	361	6	event	event	NN
cord-302047-vv5gpldi	361	7	,	,	,
cord-302047-vv5gpldi	361	8	the	the	DT
cord-302047-vv5gpldi	361	9	integrated	integrate	VBN
cord-302047-vv5gpldi	361	10	viral	viral	JJ
cord-302047-vv5gpldi	361	11	DNA	dna	NN
cord-302047-vv5gpldi	361	12	often	often	RB
cord-302047-vv5gpldi	361	13	contains	contain	VBZ
cord-302047-vv5gpldi	361	14	deletion	deletion	NN
cord-302047-vv5gpldi	361	15	,	,	,
cord-302047-vv5gpldi	361	16	inversions	inversion	NNS
cord-302047-vv5gpldi	361	17	and	and	CC
cord-302047-vv5gpldi	361	18	duplications	duplication	NNS
cord-302047-vv5gpldi	361	19	,	,	,
cord-302047-vv5gpldi	361	20	often	often	RB
cord-302047-vv5gpldi	361	21	inactivating	inactivate	VBG
cord-302047-vv5gpldi	361	22	the	the	DT
cord-302047-vv5gpldi	361	23	virus	virus	NN
cord-302047-vv5gpldi	361	24	.	.	.
cord-302047-vv5gpldi	362	1	In	in	IN
cord-302047-vv5gpldi	362	2	the	the	DT
cord-302047-vv5gpldi	362	3	case	case	NN
cord-302047-vv5gpldi	362	4	of	of	IN
cord-302047-vv5gpldi	362	5	Hepatitis	Hepatitis	NNP
cord-302047-vv5gpldi	362	6	B	B	NNP
cord-302047-vv5gpldi	362	7	virus	virus	NN
cord-302047-vv5gpldi	362	8	(	(	-LRB-
cord-302047-vv5gpldi	362	9	HBV	HBV	NNP
cord-302047-vv5gpldi	362	10	)	)	-RRB-
cord-302047-vv5gpldi	362	11	,	,	,
cord-302047-vv5gpldi	362	12	integration	integration	NN
cord-302047-vv5gpldi	362	13	into	into	IN
cord-302047-vv5gpldi	362	14	the	the	DT
cord-302047-vv5gpldi	362	15	human	human	JJ
cord-302047-vv5gpldi	362	16	genome	genome	NN
cord-302047-vv5gpldi	362	17	can	can	MD
cord-302047-vv5gpldi	362	18	cause	cause	VB
cord-302047-vv5gpldi	362	19	genetic	genetic	JJ
cord-302047-vv5gpldi	362	20	damage	damage	NN
cord-302047-vv5gpldi	362	21	and	and	CC
cord-302047-vv5gpldi	362	22	chromosomal	chromosomal	JJ
cord-302047-vv5gpldi	362	23	instability	instability	NN
cord-302047-vv5gpldi	362	24	leading	lead	VBG
cord-302047-vv5gpldi	362	25	to	to	IN
cord-302047-vv5gpldi	362	26	HBV	HBV	NNP
cord-302047-vv5gpldi	362	27	-	-	HYPH
cord-302047-vv5gpldi	362	28	induced	induce	VBN
cord-302047-vv5gpldi	362	29	liver	liver	NN
cord-302047-vv5gpldi	362	30	cancer	cancer	NN
cord-302047-vv5gpldi	362	31	(	(	-LRB-
cord-302047-vv5gpldi	362	32	Shafritz	Shafritz	NNP
cord-302047-vv5gpldi	362	33	et	et	NNP
cord-302047-vv5gpldi	362	34	al.1981	al.1981	NNP
cord-302047-vv5gpldi	362	35	;	;	:
cord-302047-vv5gpldi	363	1	Furuta	Furuta	NNP
cord-302047-vv5gpldi	363	2	et	et	FW
cord-302047-vv5gpldi	363	3	al	al	NNP
cord-302047-vv5gpldi	363	4	.	.	.
cord-302047-vv5gpldi	363	5	2018	2018	CD
cord-302047-vv5gpldi	363	6	)	)	-RRB-
cord-302047-vv5gpldi	363	7	.	.	.
cord-302047-vv5gpldi	364	1	Several	several	JJ
cord-302047-vv5gpldi	364	2	studies	study	NNS
cord-302047-vv5gpldi	364	3	in	in	IN
cord-302047-vv5gpldi	364	4	the	the	DT
cord-302047-vv5gpldi	364	5	1980s	1980	NNS
cord-302047-vv5gpldi	364	6	already	already	RB
cord-302047-vv5gpldi	364	7	reported	report	VBD
cord-302047-vv5gpldi	364	8	the	the	DT
cord-302047-vv5gpldi	364	9	possibility	possibility	NN
cord-302047-vv5gpldi	364	10	of	of	IN
cord-302047-vv5gpldi	364	11	inserting	insert	VBG
cord-302047-vv5gpldi	364	12	foreign	foreign	JJ
cord-302047-vv5gpldi	364	13	DNA	dna	NN
cord-302047-vv5gpldi	364	14	into	into	IN
cord-302047-vv5gpldi	364	15	specific	specific	JJ
cord-302047-vv5gpldi	364	16	sites	site	NNS
cord-302047-vv5gpldi	364	17	of	of	IN
cord-302047-vv5gpldi	364	18	the	the	DT
cord-302047-vv5gpldi	364	19	cauliflower	cauliflower	NNP
cord-302047-vv5gpldi	364	20	mosaic	mosaic	NNP
cord-302047-vv5gpldi	364	21	virus	virus	NN
cord-302047-vv5gpldi	364	22	(	(	-LRB-
cord-302047-vv5gpldi	364	23	CaMV	CaMV	NNP
cord-302047-vv5gpldi	364	24	)	)	-RRB-
cord-302047-vv5gpldi	364	25	genome	genome	NN
cord-302047-vv5gpldi	364	26	without	without	IN
cord-302047-vv5gpldi	364	27	greatly	greatly	RB
cord-302047-vv5gpldi	364	28	affecting	affect	VBG
cord-302047-vv5gpldi	364	29	viral	viral	JJ
cord-302047-vv5gpldi	364	30	infectivity	infectivity	NN
cord-302047-vv5gpldi	364	31	or	or	CC
cord-302047-vv5gpldi	364	32	function	function	NN
cord-302047-vv5gpldi	364	33	(	(	-LRB-
cord-302047-vv5gpldi	364	34	Gronenborn	Gronenborn	NNP
cord-302047-vv5gpldi	364	35	et	et	NNP
cord-302047-vv5gpldi	364	36	al	al	NNP
cord-302047-vv5gpldi	364	37	.	.	NNP
cord-302047-vv5gpldi	364	38	1981	1981	CD
cord-302047-vv5gpldi	364	39	;	;	:
cord-302047-vv5gpldi	364	40	Howell	Howell	NNP
cord-302047-vv5gpldi	364	41	,	,	,
cord-302047-vv5gpldi	364	42	Walker	Walker	NNP
cord-302047-vv5gpldi	364	43	,	,	,
cord-302047-vv5gpldi	364	44	and	and	CC
cord-302047-vv5gpldi	364	45	Walden	Walden	NNP
cord-302047-vv5gpldi	364	46	1981	1981	CD
cord-302047-vv5gpldi	364	47	;	;	:
cord-302047-vv5gpldi	364	48	Dixon	Dixon	NNP
cord-302047-vv5gpldi	364	49	,	,	,
cord-302047-vv5gpldi	364	50	Koenig	Koenig	NNP
cord-302047-vv5gpldi	364	51	,	,	,
cord-302047-vv5gpldi	364	52	and	and	CC
cord-302047-vv5gpldi	364	53	Hohn	Hohn	NNP
cord-302047-vv5gpldi	364	54	1983	1983	CD
cord-302047-vv5gpldi	364	55	;	;	:
cord-302047-vv5gpldi	364	56	Brisson	Brisson	NNP
cord-302047-vv5gpldi	364	57	et	et	NNP
cord-302047-vv5gpldi	364	58	al	al	NNP
cord-302047-vv5gpldi	364	59	.	.	.
cord-302047-vv5gpldi	365	1	1984	1984	CD
cord-302047-vv5gpldi	365	2	;	;	:
cord-302047-vv5gpldi	365	3	Lefebvre	Lefebvre	NNP
cord-302047-vv5gpldi	365	4	,	,	,
cord-302047-vv5gpldi	365	5	Miki	Miki	NNP
cord-302047-vv5gpldi	365	6	,	,	,
cord-302047-vv5gpldi	365	7	and	and	CC
cord-302047-vv5gpldi	365	8	Laliberté	Laliberté	NNP
cord-302047-vv5gpldi	365	9	1987	1987	CD
cord-302047-vv5gpldi	365	10	)	)	-RRB-
cord-302047-vv5gpldi	365	11	.	.	.
cord-302047-vv5gpldi	366	1	In	in	IN
cord-302047-vv5gpldi	366	2	two	two	CD
cord-302047-vv5gpldi	366	3	of	of	IN
cord-302047-vv5gpldi	366	4	these	these	DT
cord-302047-vv5gpldi	366	5	studies	study	NNS
cord-302047-vv5gpldi	366	6	,	,	,
cord-302047-vv5gpldi	366	7	functional	functional	JJ
cord-302047-vv5gpldi	366	8	bacterial	bacterial	JJ
cord-302047-vv5gpldi	366	9	genes	gene	NNS
cord-302047-vv5gpldi	366	10	were	be	VBD
cord-302047-vv5gpldi	366	11	introduced	introduce	VBN
cord-302047-vv5gpldi	366	12	into	into	IN
cord-302047-vv5gpldi	366	13	the	the	DT
cord-302047-vv5gpldi	366	14	CaMV	CaMV	NNP
cord-302047-vv5gpldi	366	15	genome	genome	NN
cord-302047-vv5gpldi	366	16	,	,	,
cord-302047-vv5gpldi	366	17	where	where	WRB
cord-302047-vv5gpldi	366	18	a	a	DT
cord-302047-vv5gpldi	366	19	fragment	fragment	NN
cord-302047-vv5gpldi	366	20	of	of	IN
cord-302047-vv5gpldi	366	21	the	the	DT
cord-302047-vv5gpldi	366	22	lac	lac	NNP
cord-302047-vv5gpldi	366	23	operator	operator	NN
cord-302047-vv5gpldi	366	24	(	(	-LRB-
cord-302047-vv5gpldi	366	25	Gronenborn	Gronenborn	NNP
cord-302047-vv5gpldi	366	26	et	et	NNP
cord-302047-vv5gpldi	366	27	al	al	NNP
cord-302047-vv5gpldi	366	28	.	.	NNP
cord-302047-vv5gpldi	366	29	1981	1981	CD
cord-302047-vv5gpldi	366	30	)	)	-RRB-
cord-302047-vv5gpldi	366	31	and	and	CC
cord-302047-vv5gpldi	366	32	the	the	DT
cord-302047-vv5gpldi	366	33	DHFR	DHFR	NNP
cord-302047-vv5gpldi	366	34	gene	gene	NN
cord-302047-vv5gpldi	366	35	(	(	-LRB-
cord-302047-vv5gpldi	366	36	Brisson	Brisson	NNP
cord-302047-vv5gpldi	366	37	et	et	NNP
cord-302047-vv5gpldi	366	38	al	al	NNP
cord-302047-vv5gpldi	366	39	.	.	.
cord-302047-vv5gpldi	366	40	1984	1984	CD
cord-302047-vv5gpldi	366	41	)	)	-RRB-
cord-302047-vv5gpldi	366	42	were	be	VBD
cord-302047-vv5gpldi	366	43	successfully	successfully	RB
cord-302047-vv5gpldi	366	44	expressed	express	VBN
cord-302047-vv5gpldi	366	45	.	.	.
cord-302047-vv5gpldi	367	1	In	in	IN
cord-302047-vv5gpldi	367	2	these	these	DT
cord-302047-vv5gpldi	367	3	studies	study	NNS
cord-302047-vv5gpldi	367	4	,	,	,
cord-302047-vv5gpldi	367	5	issues	issue	NNS
cord-302047-vv5gpldi	367	6	regarding	regard	VBG
cord-302047-vv5gpldi	367	7	the	the	DT
cord-302047-vv5gpldi	367	8	stability	stability	NN
cord-302047-vv5gpldi	367	9	of	of	IN
cord-302047-vv5gpldi	367	10	the	the	DT
cord-302047-vv5gpldi	367	11	insert	insert	NN
cord-302047-vv5gpldi	367	12	were	be	VBD
cord-302047-vv5gpldi	367	13	raised	raise	VBN
cord-302047-vv5gpldi	367	14	,	,	,
cord-302047-vv5gpldi	367	15	where	where	WRB
cord-302047-vv5gpldi	367	16	the	the	DT
cord-302047-vv5gpldi	367	17	lac	lac	NNP
cord-302047-vv5gpldi	367	18	operator	operator	NN
cord-302047-vv5gpldi	367	19	was	be	VBD
cord-302047-vv5gpldi	367	20	lost	lose	VBN
cord-302047-vv5gpldi	367	21	after	after	IN
cord-302047-vv5gpldi	367	22	five	five	CD
cord-302047-vv5gpldi	367	23	successive	successive	JJ
cord-302047-vv5gpldi	367	24	transfers	transfer	NNS
cord-302047-vv5gpldi	367	25	and	and	CC
cord-302047-vv5gpldi	367	26	extended	extended	JJ
cord-302047-vv5gpldi	367	27	growth	growth	NN
cord-302047-vv5gpldi	367	28	of	of	IN
cord-302047-vv5gpldi	367	29	the	the	DT
cord-302047-vv5gpldi	367	30	plants	plant	NNS
cord-302047-vv5gpldi	367	31	,	,	,
cord-302047-vv5gpldi	367	32	and	and	CC
cord-302047-vv5gpldi	367	33	deletions	deletion	NNS
cord-302047-vv5gpldi	367	34	in	in	IN
cord-302047-vv5gpldi	367	35	the	the	DT
cord-302047-vv5gpldi	367	36	DHFR	DHFR	NNP
cord-302047-vv5gpldi	367	37	gene	gene	NN
cord-302047-vv5gpldi	367	38	started	start	VBD
cord-302047-vv5gpldi	367	39	appearing	appear	VBG
cord-302047-vv5gpldi	367	40	after	after	IN
cord-302047-vv5gpldi	367	41	the	the	DT
cord-302047-vv5gpldi	367	42	second	second	JJ
cord-302047-vv5gpldi	367	43	and	and	CC
cord-302047-vv5gpldi	367	44	third	third	JJ
cord-302047-vv5gpldi	367	45	transfers	transfer	NNS
cord-302047-vv5gpldi	367	46	.	.	.
cord-302047-vv5gpldi	368	1	On	on	IN
cord-302047-vv5gpldi	368	2	the	the	DT
cord-302047-vv5gpldi	368	3	contrary	contrary	NN
cord-302047-vv5gpldi	368	4	,	,	,
cord-302047-vv5gpldi	368	5	an	an	DT
cord-302047-vv5gpldi	368	6	inserted	insert	VBN
cord-302047-vv5gpldi	368	7	mammalian	mammalian	JJ
cord-302047-vv5gpldi	368	8	metallothionein	metallothionein	NNP
cord-302047-vv5gpldi	368	9	gene	gene	NN
cord-302047-vv5gpldi	368	10	appeared	appear	VBD
cord-302047-vv5gpldi	368	11	to	to	TO
cord-302047-vv5gpldi	368	12	be	be	VB
cord-302047-vv5gpldi	368	13	stable	stable	JJ
cord-302047-vv5gpldi	368	14	and	and	CC
cord-302047-vv5gpldi	368	15	functional	functional	JJ
cord-302047-vv5gpldi	368	16	in	in	IN
cord-302047-vv5gpldi	368	17	the	the	DT
cord-302047-vv5gpldi	368	18	CaMV	CaMV	NNP
cord-302047-vv5gpldi	368	19	genome	genome	NN
cord-302047-vv5gpldi	368	20	(	(	-LRB-
cord-302047-vv5gpldi	368	21	Lefebvre	Lefebvre	NNP
cord-302047-vv5gpldi	368	22	,	,	,
cord-302047-vv5gpldi	368	23	Miki	Miki	NNP
cord-302047-vv5gpldi	368	24	,	,	,
cord-302047-vv5gpldi	368	25	and	and	CC
cord-302047-vv5gpldi	368	26	Laliberté	Laliberté	NNP
cord-302047-vv5gpldi	368	27	1987	1987	CD
cord-302047-vv5gpldi	368	28	)	)	-RRB-
cord-302047-vv5gpldi	368	29	.	.	.
cord-302047-vv5gpldi	369	1	These	these	DT
cord-302047-vv5gpldi	369	2	studies	study	NNS
cord-302047-vv5gpldi	369	3	suggest	suggest	VBP
cord-302047-vv5gpldi	369	4	that	that	IN
cord-302047-vv5gpldi	369	5	the	the	DT
cord-302047-vv5gpldi	369	6	differences	difference	NNS
cord-302047-vv5gpldi	369	7	in	in	IN
cord-302047-vv5gpldi	369	8	stability	stability	NN
cord-302047-vv5gpldi	369	9	of	of	IN
cord-302047-vv5gpldi	369	10	inserts	insert	NNS
cord-302047-vv5gpldi	369	11	in	in	IN
cord-302047-vv5gpldi	369	12	the	the	DT
cord-302047-vv5gpldi	369	13	CaMV	CaMV	NNP
cord-302047-vv5gpldi	369	14	genome	genome	NN
cord-302047-vv5gpldi	369	15	depend	depend	VBP
cord-302047-vv5gpldi	369	16	on	on	IN
cord-302047-vv5gpldi	369	17	at	at	RB
cord-302047-vv5gpldi	369	18	least	least	RBS
cord-302047-vv5gpldi	369	19	two	two	CD
cord-302047-vv5gpldi	369	20	factors	factor	NNS
cord-302047-vv5gpldi	369	21	.	.	.
cord-302047-vv5gpldi	370	1	First	first	RB
cord-302047-vv5gpldi	370	2	,	,	,
cord-302047-vv5gpldi	370	3	the	the	DT
cord-302047-vv5gpldi	370	4	site	site	NN
cord-302047-vv5gpldi	370	5	of	of	IN
cord-302047-vv5gpldi	370	6	the	the	DT
cord-302047-vv5gpldi	370	7	insert	insert	NN
cord-302047-vv5gpldi	370	8	seems	seem	VBZ
cord-302047-vv5gpldi	370	9	to	to	TO
cord-302047-vv5gpldi	370	10	be	be	VB
cord-302047-vv5gpldi	370	11	important	important	JJ
cord-302047-vv5gpldi	370	12	as	as	IN
cord-302047-vv5gpldi	370	13	many	many	JJ
cord-302047-vv5gpldi	370	14	inserts	insert	NNS
cord-302047-vv5gpldi	370	15	are	be	VBP
cord-302047-vv5gpldi	370	16	lethal	lethal	JJ
cord-302047-vv5gpldi	370	17	for	for	IN
cord-302047-vv5gpldi	370	18	the	the	DT
cord-302047-vv5gpldi	370	19	virus	virus	NN
cord-302047-vv5gpldi	371	1	(	(	-LRB-
cord-302047-vv5gpldi	371	2	Gronenborn	Gronenborn	NNP
cord-302047-vv5gpldi	371	3	et	et	NNP
cord-302047-vv5gpldi	371	4	al	al	NNP
cord-302047-vv5gpldi	371	5	.	.	NNP
cord-302047-vv5gpldi	371	6	1981	1981	CD
cord-302047-vv5gpldi	371	7	;	;	:
cord-302047-vv5gpldi	371	8	Howell	Howell	NNP
cord-302047-vv5gpldi	371	9	,	,	,
cord-302047-vv5gpldi	371	10	Walker	Walker	NNP
cord-302047-vv5gpldi	371	11	,	,	,
cord-302047-vv5gpldi	371	12	and	and	CC
cord-302047-vv5gpldi	371	13	Walden	Walden	NNP
cord-302047-vv5gpldi	371	14	1981	1981	CD
cord-302047-vv5gpldi	371	15	;	;	:
cord-302047-vv5gpldi	372	1	Dixon	Dixon	NNP
cord-302047-vv5gpldi	372	2	,	,	,
cord-302047-vv5gpldi	372	3	Koenig	Koenig	NNP
cord-302047-vv5gpldi	372	4	,	,	,
cord-302047-vv5gpldi	372	5	and	and	CC
cord-302047-vv5gpldi	372	6	Hohn	Hohn	NNP
cord-302047-vv5gpldi	372	7	1983	1983	CD
cord-302047-vv5gpldi	372	8	)	)	-RRB-
cord-302047-vv5gpldi	372	9	.	.	.
cord-302047-vv5gpldi	373	1	Second	second	RB
cord-302047-vv5gpldi	373	2	,	,	,
cord-302047-vv5gpldi	373	3	the	the	DT
cord-302047-vv5gpldi	373	4	size	size	NN
cord-302047-vv5gpldi	373	5	of	of	IN
cord-302047-vv5gpldi	373	6	the	the	DT
cord-302047-vv5gpldi	373	7	insert	insert	NN
cord-302047-vv5gpldi	373	8	is	be	VBZ
cord-302047-vv5gpldi	373	9	important	important	JJ
cord-302047-vv5gpldi	373	10	,	,	,
cord-302047-vv5gpldi	373	11	as	as	IN
cord-302047-vv5gpldi	373	12	CaMV	CaMV	NNP
cord-302047-vv5gpldi	373	13	can	can	MD
cord-302047-vv5gpldi	373	14	accept	accept	VB
cord-302047-vv5gpldi	373	15	only	only	JJ
cord-302047-vv5gpldi	373	16	small	small	JJ
cord-302047-vv5gpldi	373	17	foreign	foreign	JJ
cord-302047-vv5gpldi	373	18	genes	gene	NNS
cord-302047-vv5gpldi	373	19	due	due	JJ
cord-302047-vv5gpldi	373	20	to	to	IN
cord-302047-vv5gpldi	373	21	viral	viral	JJ
cord-302047-vv5gpldi	373	22	encapsidation	encapsidation	NN
cord-302047-vv5gpldi	373	23	limits	limit	NNS
cord-302047-vv5gpldi	373	24	(	(	-LRB-
cord-302047-vv5gpldi	373	25	Gronenborn	Gronenborn	NNP
cord-302047-vv5gpldi	373	26	et	et	NNP
cord-302047-vv5gpldi	373	27	al	al	NNP
cord-302047-vv5gpldi	373	28	.	.	NNP
cord-302047-vv5gpldi	373	29	1981	1981	CD
cord-302047-vv5gpldi	373	30	;	;	:
cord-302047-vv5gpldi	373	31	Lefebvre	Lefebvre	NNP
cord-302047-vv5gpldi	373	32	,	,	,
cord-302047-vv5gpldi	373	33	Miki	Miki	NNP
cord-302047-vv5gpldi	373	34	,	,	,
cord-302047-vv5gpldi	373	35	and	and	CC
cord-302047-vv5gpldi	373	36	Laliberté	Laliberté	NNP
cord-302047-vv5gpldi	373	37	1987	1987	CD
cord-302047-vv5gpldi	373	38	)	)	-RRB-
cord-302047-vv5gpldi	373	39	.	.	.
cord-302047-vv5gpldi	374	1	As	as	IN
cord-302047-vv5gpldi	374	2	described	describe	VBN
cord-302047-vv5gpldi	374	3	along	along	IN
cord-302047-vv5gpldi	374	4	this	this	DT
cord-302047-vv5gpldi	374	5	review	review	NN
cord-302047-vv5gpldi	374	6	,	,	,
cord-302047-vv5gpldi	374	7	vectors	vector	NNS
cord-302047-vv5gpldi	374	8	containing	contain	VBG
cord-302047-vv5gpldi	374	9	the	the	DT
cord-302047-vv5gpldi	374	10	GFP	GFP	NNP
cord-302047-vv5gpldi	374	11	as	as	IN
cord-302047-vv5gpldi	374	12	an	an	DT
cord-302047-vv5gpldi	374	13	insert	insert	NN
cord-302047-vv5gpldi	374	14	are	be	VBP
cord-302047-vv5gpldi	374	15	often	often	RB
cord-302047-vv5gpldi	374	16	designed	design	VBN
cord-302047-vv5gpldi	374	17	to	to	TO
cord-302047-vv5gpldi	374	18	study	study	VB
cord-302047-vv5gpldi	374	19	the	the	DT
cord-302047-vv5gpldi	374	20	infection	infection	NN
cord-302047-vv5gpldi	374	21	dynamics	dynamic	NNS
cord-302047-vv5gpldi	374	22	of	of	IN
cord-302047-vv5gpldi	374	23	viruses	virus	NNS
cord-302047-vv5gpldi	374	24	.	.	.
cord-302047-vv5gpldi	375	1	However	however	RB
cord-302047-vv5gpldi	375	2	,	,	,
cord-302047-vv5gpldi	375	3	the	the	DT
cord-302047-vv5gpldi	375	4	size	size	NN
cord-302047-vv5gpldi	375	5	of	of	IN
cord-302047-vv5gpldi	375	6	GFP	GFP	NNP
cord-302047-vv5gpldi	375	7	is	be	VBZ
cord-302047-vv5gpldi	375	8	relatively	relatively	RB
cord-302047-vv5gpldi	375	9	large	large	JJ
cord-302047-vv5gpldi	375	10	(	(	-LRB-
cord-302047-vv5gpldi	375	11	around	around	RB
cord-302047-vv5gpldi	375	12	700	700	CD
cord-302047-vv5gpldi	375	13	nt	nt	NN
cord-302047-vv5gpldi	375	14	)	)	-RRB-
cord-302047-vv5gpldi	375	15	and	and	CC
cord-302047-vv5gpldi	375	16	often	often	RB
cord-302047-vv5gpldi	375	17	leads	lead	VBZ
cord-302047-vv5gpldi	375	18	to	to	IN
cord-302047-vv5gpldi	375	19	instability	instability	NN
cord-302047-vv5gpldi	375	20	of	of	IN
cord-302047-vv5gpldi	375	21	vectors	vector	NNS
cord-302047-vv5gpldi	375	22	(	(	-LRB-
cord-302047-vv5gpldi	375	23	Zwart	Zwart	NNP
cord-302047-vv5gpldi	375	24	et	et	FW
cord-302047-vv5gpldi	375	25	al	al	NNP
cord-302047-vv5gpldi	375	26	.	.	.
cord-302047-vv5gpldi	376	1	2014	2014	CD
cord-302047-vv5gpldi	376	2	;	;	:
cord-302047-vv5gpldi	376	3	Nakane	Nakane	NNP
cord-302047-vv5gpldi	376	4	,	,	,
cord-302047-vv5gpldi	376	5	Iwamoto	Iwamoto	NNP
cord-302047-vv5gpldi	376	6	,	,	,
cord-302047-vv5gpldi	376	7	and	and	CC
cord-302047-vv5gpldi	376	8	Matsuda	Matsuda	NNP
cord-302047-vv5gpldi	376	9	2015	2015	CD
cord-302047-vv5gpldi	376	10	)	)	-RRB-
cord-302047-vv5gpldi	376	11	.	.	.
cord-302047-vv5gpldi	377	1	To	to	TO
cord-302047-vv5gpldi	377	2	cope	cope	VB
cord-302047-vv5gpldi	377	3	with	with	IN
cord-302047-vv5gpldi	377	4	the	the	DT
cord-302047-vv5gpldi	377	5	size	size	NN
cord-302047-vv5gpldi	377	6	limitation	limitation	NN
cord-302047-vv5gpldi	377	7	a	a	DT
cord-302047-vv5gpldi	377	8	split	split	VBN
cord-302047-vv5gpldi	377	9	GFP	GFP	NNP
cord-302047-vv5gpldi	377	10	system	system	NN
cord-302047-vv5gpldi	377	11	has	have	VBZ
cord-302047-vv5gpldi	377	12	been	be	VBN
cord-302047-vv5gpldi	377	13	engineered	engineer	VBN
cord-302047-vv5gpldi	377	14	(	(	-LRB-
cord-302047-vv5gpldi	377	15	Cabantous	Cabantous	NNP
cord-302047-vv5gpldi	377	16	,	,	,
cord-302047-vv5gpldi	377	17	Terwilliger	Terwilliger	NNP
cord-302047-vv5gpldi	377	18	,	,	,
cord-302047-vv5gpldi	377	19	and	and	CC
cord-302047-vv5gpldi	377	20	Waldo	Waldo	NNP
cord-302047-vv5gpldi	377	21	2005	2005	CD
cord-302047-vv5gpldi	377	22	)	)	-RRB-
cord-302047-vv5gpldi	377	23	,	,	,
cord-302047-vv5gpldi	377	24	where	where	WRB
cord-302047-vv5gpldi	377	25	only	only	RB
cord-302047-vv5gpldi	377	26	a	a	DT
cord-302047-vv5gpldi	377	27	small	small	JJ
cord-302047-vv5gpldi	377	28	part	part	NN
cord-302047-vv5gpldi	377	29	of	of	IN
cord-302047-vv5gpldi	377	30	GFP	GFP	NNP
cord-302047-vv5gpldi	377	31	is	be	VBZ
cord-302047-vv5gpldi	377	32	introduced	introduce	VBN
cord-302047-vv5gpldi	377	33	in	in	IN
cord-302047-vv5gpldi	377	34	the	the	DT
cord-302047-vv5gpldi	377	35	viral	viral	JJ
cord-302047-vv5gpldi	377	36	vector	vector	NN
cord-302047-vv5gpldi	377	37	and	and	CC
cord-302047-vv5gpldi	377	38	the	the	DT
cord-302047-vv5gpldi	377	39	other	other	JJ
cord-302047-vv5gpldi	377	40	part	part	NN
cord-302047-vv5gpldi	377	41	is	be	VBZ
cord-302047-vv5gpldi	377	42	expressed	express	VBN
cord-302047-vv5gpldi	377	43	using	use	VBG
cord-302047-vv5gpldi	377	44	a	a	DT
cord-302047-vv5gpldi	377	45	transgenic	transgenic	JJ
cord-302047-vv5gpldi	377	46	host	host	NN
cord-302047-vv5gpldi	377	47	.	.	.
cord-302047-vv5gpldi	378	1	When	when	WRB
cord-302047-vv5gpldi	378	2	the	the	DT
cord-302047-vv5gpldi	378	3	two	two	CD
cord-302047-vv5gpldi	378	4	GFP	GFP	NNP
cord-302047-vv5gpldi	378	5	fragments	fragment	NNS
cord-302047-vv5gpldi	378	6	are	be	VBP
cord-302047-vv5gpldi	378	7	together	together	RB
cord-302047-vv5gpldi	378	8	,	,	,
cord-302047-vv5gpldi	378	9	spontaneous	spontaneous	JJ
cord-302047-vv5gpldi	378	10	association	association	NNP
cord-302047-vv5gpldi	378	11	leads	lead	VBZ
cord-302047-vv5gpldi	378	12	the	the	DT
cord-302047-vv5gpldi	378	13	formation	formation	NN
cord-302047-vv5gpldi	378	14	of	of	IN
cord-302047-vv5gpldi	378	15	a	a	DT
cord-302047-vv5gpldi	378	16	fluorescent	fluorescent	NN
cord-302047-vv5gpldi	378	17	molecule	molecule	NN
cord-302047-vv5gpldi	378	18	.	.	.
cord-302047-vv5gpldi	379	1	In	in	IN
cord-302047-vv5gpldi	379	2	the	the	DT
cord-302047-vv5gpldi	379	3	CaMV	CaMV	NNP
cord-302047-vv5gpldi	379	4	genome	genome	NN
cord-302047-vv5gpldi	379	5	this	this	DT
cord-302047-vv5gpldi	379	6	system	system	NN
cord-302047-vv5gpldi	379	7	allowed	allow	VBD
cord-302047-vv5gpldi	379	8	to	to	TO
cord-302047-vv5gpldi	379	9	track	track	VB
cord-302047-vv5gpldi	379	10	a	a	DT
cord-302047-vv5gpldi	379	11	CaMV	CaMV	NNP
cord-302047-vv5gpldi	379	12	protein	protein	NN
cord-302047-vv5gpldi	379	13	in	in	IN
cord-302047-vv5gpldi	379	14	vivo	vivo	NNP
cord-302047-vv5gpldi	379	15	(	(	-LRB-
cord-302047-vv5gpldi	379	16	Dá	Dá	NNP
cord-302047-vv5gpldi	379	17	der	der	FW
cord-302047-vv5gpldi	379	18	et	et	FW
cord-302047-vv5gpldi	379	19	al	al	NNP
cord-302047-vv5gpldi	379	20	.	.	.
cord-302047-vv5gpldi	379	21	2019	2019	CD
cord-302047-vv5gpldi	379	22	)	)	-RRB-
cord-302047-vv5gpldi	379	23	.	.	.
cord-302047-vv5gpldi	380	1	The	the	DT
cord-302047-vv5gpldi	380	2	partial	partial	JJ
cord-302047-vv5gpldi	380	3	GFP	GFP	NNP
cord-302047-vv5gpldi	380	4	insertion	insertion	NN
cord-302047-vv5gpldi	380	5	was	be	VBD
cord-302047-vv5gpldi	380	6	stable	stable	JJ
cord-302047-vv5gpldi	380	7	for	for	IN
cord-302047-vv5gpldi	380	8	ten	ten	CD
cord-302047-vv5gpldi	380	9	or	or	CC
cord-302047-vv5gpldi	380	10	four	four	CD
cord-302047-vv5gpldi	380	11	serial	serial	JJ
cord-302047-vv5gpldi	380	12	passages	passage	NNS
cord-302047-vv5gpldi	380	13	,	,	,
cord-302047-vv5gpldi	380	14	depending	depend	VBG
cord-302047-vv5gpldi	380	15	on	on	IN
cord-302047-vv5gpldi	380	16	the	the	DT
cord-302047-vv5gpldi	380	17	host	host	NN
cord-302047-vv5gpldi	380	18	plant	plant	NN
cord-302047-vv5gpldi	380	19	species	specie	NNS
cord-302047-vv5gpldi	380	20	used	use	VBN
cord-302047-vv5gpldi	380	21	,	,	,
cord-302047-vv5gpldi	380	22	suggesting	suggest	VBG
cord-302047-vv5gpldi	380	23	that	that	IN
cord-302047-vv5gpldi	380	24	the	the	DT
cord-302047-vv5gpldi	380	25	demographic	demographic	JJ
cord-302047-vv5gpldi	380	26	conditions	condition	NNS
cord-302047-vv5gpldi	380	27	such	such	JJ
cord-302047-vv5gpldi	380	28	as	as	IN
cord-302047-vv5gpldi	380	29	the	the	DT
cord-302047-vv5gpldi	380	30	host	host	NN
cord-302047-vv5gpldi	380	31	play	play	VBP
cord-302047-vv5gpldi	380	32	an	an	DT
cord-302047-vv5gpldi	380	33	important	important	JJ
cord-302047-vv5gpldi	380	34	role	role	NN
cord-302047-vv5gpldi	380	35	in	in	IN
cord-302047-vv5gpldi	380	36	stability	stability	NN
cord-302047-vv5gpldi	380	37	.	.	.
cord-302047-vv5gpldi	381	1	Although	although	IN
cord-302047-vv5gpldi	381	2	the	the	DT
cord-302047-vv5gpldi	381	3	number	number	NN
cord-302047-vv5gpldi	381	4	of	of	IN
cord-302047-vv5gpldi	381	5	studies	study	NNS
cord-302047-vv5gpldi	381	6	on	on	IN
cord-302047-vv5gpldi	381	7	insert	insert	JJ
cord-302047-vv5gpldi	381	8	stability	stability	NN
cord-302047-vv5gpldi	381	9	in	in	IN
cord-302047-vv5gpldi	381	10	RT	RT	NNP
cord-302047-vv5gpldi	381	11	-	-	HYPH
cord-302047-vv5gpldi	381	12	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	381	13	viruses	virus	NNS
cord-302047-vv5gpldi	381	14	is	be	VBZ
cord-302047-vv5gpldi	381	15	limited	limit	VBN
cord-302047-vv5gpldi	381	16	,	,	,
cord-302047-vv5gpldi	381	17	we	-PRON-	PRP
cord-302047-vv5gpldi	381	18	reason	reason	VBP
cord-302047-vv5gpldi	381	19	that	that	IN
cord-302047-vv5gpldi	381	20	several	several	JJ
cord-302047-vv5gpldi	381	21	constraints	constraint	NNS
cord-302047-vv5gpldi	381	22	limit	limit	VBP
cord-302047-vv5gpldi	381	23	insert	insert	JJ
cord-302047-vv5gpldi	381	24	stability	stability	NN
cord-302047-vv5gpldi	381	25	in	in	IN
cord-302047-vv5gpldi	381	26	these	these	DT
cord-302047-vv5gpldi	381	27	viruses	virus	NNS
cord-302047-vv5gpldi	381	28	.	.	.
cord-302047-vv5gpldi	382	1	Although	although	IN
cord-302047-vv5gpldi	382	2	small	small	JJ
cord-302047-vv5gpldi	382	3	inserts	insert	NNS
cord-302047-vv5gpldi	382	4	will	will	MD
cord-302047-vv5gpldi	382	5	allow	allow	VB
cord-302047-vv5gpldi	382	6	to	to	TO
cord-302047-vv5gpldi	382	7	track	track	VB
cord-302047-vv5gpldi	382	8	viral	viral	JJ
cord-302047-vv5gpldi	382	9	infection	infection	NN
cord-302047-vv5gpldi	382	10	dynamics	dynamic	NNS
cord-302047-vv5gpldi	382	11	,	,	,
cord-302047-vv5gpldi	382	12	the	the	DT
cord-302047-vv5gpldi	382	13	use	use	NN
cord-302047-vv5gpldi	382	14	of	of	IN
cord-302047-vv5gpldi	382	15	RT	RT	NNP
cord-302047-vv5gpldi	382	16	-	-	HYPH
cord-302047-vv5gpldi	382	17	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	382	18	viruses	virus	NNS
cord-302047-vv5gpldi	382	19	for	for	IN
cord-302047-vv5gpldi	382	20	gene	gene	NN
cord-302047-vv5gpldi	382	21	therapy	therapy	NN
cord-302047-vv5gpldi	382	22	does	do	VBZ
cord-302047-vv5gpldi	382	23	not	not	RB
cord-302047-vv5gpldi	382	24	seem	seem	VB
cord-302047-vv5gpldi	382	25	practicable	practicable	JJ
cord-302047-vv5gpldi	382	26	as	as	IN
cord-302047-vv5gpldi	382	27	integration	integration	NN
cord-302047-vv5gpldi	382	28	into	into	IN
cord-302047-vv5gpldi	382	29	the	the	DT
cord-302047-vv5gpldi	382	30	host	host	NN
cord-302047-vv5gpldi	382	31	genome	genome	NN
cord-302047-vv5gpldi	382	32	is	be	VBZ
cord-302047-vv5gpldi	382	33	a	a	DT
cord-302047-vv5gpldi	382	34	rare	rare	JJ
cord-302047-vv5gpldi	382	35	event	event	NN
cord-302047-vv5gpldi	382	36	for	for	IN
cord-302047-vv5gpldi	382	37	these	these	DT
cord-302047-vv5gpldi	382	38	viruses	virus	NNS
cord-302047-vv5gpldi	382	39	.	.	.
cord-302047-vv5gpldi	383	1	Sequence	sequence	NN
cord-302047-vv5gpldi	383	2	loss	loss	NN
cord-302047-vv5gpldi	383	3	is	be	VBZ
cord-302047-vv5gpldi	383	4	inherently	inherently	RB
cord-302047-vv5gpldi	383	5	an	an	DT
cord-302047-vv5gpldi	383	6	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	383	7	process	process	NN
cord-302047-vv5gpldi	383	8	,	,	,
cord-302047-vv5gpldi	383	9	at	at	IN
cord-302047-vv5gpldi	383	10	a	a	DT
cord-302047-vv5gpldi	383	11	minimum	minimum	JJ
cord-302047-vv5gpldi	383	12	involving	involve	VBG
cord-302047-vv5gpldi	383	13	mutation	mutation	NN
cord-302047-vv5gpldi	383	14	and	and	CC
cord-302047-vv5gpldi	383	15	selection	selection	NN
cord-302047-vv5gpldi	383	16	,	,	,
cord-302047-vv5gpldi	383	17	and	and	CC
cord-302047-vv5gpldi	383	18	therefore	therefore	RB
cord-302047-vv5gpldi	383	19	needs	need	VBZ
cord-302047-vv5gpldi	383	20	to	to	TO
cord-302047-vv5gpldi	383	21	be	be	VB
cord-302047-vv5gpldi	383	22	framed	frame	VBN
cord-302047-vv5gpldi	383	23	in	in	IN
cord-302047-vv5gpldi	383	24	an	an	DT
cord-302047-vv5gpldi	383	25	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	383	26	context	context	NN
cord-302047-vv5gpldi	383	27	.	.	.
cord-302047-vv5gpldi	384	1	Here	here	RB
cord-302047-vv5gpldi	384	2	,	,	,
cord-302047-vv5gpldi	384	3	we	-PRON-	PRP
cord-302047-vv5gpldi	384	4	consider	consider	VBP
cord-302047-vv5gpldi	384	5	how	how	WRB
cord-302047-vv5gpldi	384	6	theory	theory	NN
cord-302047-vv5gpldi	384	7	might	may	MD
cord-302047-vv5gpldi	384	8	help	help	VB
cord-302047-vv5gpldi	384	9	to	to	TO
cord-302047-vv5gpldi	384	10	better	well	RBR
cord-302047-vv5gpldi	384	11	understand	understand	VB
cord-302047-vv5gpldi	384	12	and	and	CC
cord-302047-vv5gpldi	384	13	ultimately	ultimately	RB
cord-302047-vv5gpldi	384	14	predict	predict	VBP
cord-302047-vv5gpldi	384	15	this	this	DT
cord-302047-vv5gpldi	384	16	process	process	NN
cord-302047-vv5gpldi	384	17	.	.	.
cord-302047-vv5gpldi	385	1	First	first	RB
cord-302047-vv5gpldi	385	2	,	,	,
cord-302047-vv5gpldi	385	3	inspired	inspire	VBN
cord-302047-vv5gpldi	385	4	by	by	IN
cord-302047-vv5gpldi	385	5	empirical	empirical	JJ
cord-302047-vv5gpldi	385	6	results	result	NNS
cord-302047-vv5gpldi	385	7	we	-PRON-	PRP
cord-302047-vv5gpldi	385	8	consider	consider	VBP
cord-302047-vv5gpldi	385	9	the	the	DT
cord-302047-vv5gpldi	385	10	effects	effect	NNS
cord-302047-vv5gpldi	385	11	of	of	IN
cord-302047-vv5gpldi	385	12	virus	virus	NN
cord-302047-vv5gpldi	385	13	population	population	NN
cord-302047-vv5gpldi	385	14	and	and	CC
cord-302047-vv5gpldi	385	15	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	385	16	sizes	size	NNS
cord-302047-vv5gpldi	385	17	on	on	IN
cord-302047-vv5gpldi	385	18	sequence	sequence	NN
cord-302047-vv5gpldi	385	19	loss	loss	NN
cord-302047-vv5gpldi	385	20	.	.	.
cord-302047-vv5gpldi	386	1	Second	second	RB
cord-302047-vv5gpldi	386	2	,	,	,
cord-302047-vv5gpldi	386	3	we	-PRON-	PRP
cord-302047-vv5gpldi	386	4	consider	consider	VBP
cord-302047-vv5gpldi	386	5	whether	whether	IN
cord-302047-vv5gpldi	386	6	there	there	EX
cord-302047-vv5gpldi	386	7	are	be	VBP
cord-302047-vv5gpldi	386	8	different	different	JJ
cord-302047-vv5gpldi	386	9	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	386	10	trajectories	trajectory	NNS
cord-302047-vv5gpldi	386	11	that	that	WDT
cord-302047-vv5gpldi	386	12	lead	lead	VBP
cord-302047-vv5gpldi	386	13	to	to	IN
cord-302047-vv5gpldi	386	14	a	a	DT
cord-302047-vv5gpldi	386	15	restoration	restoration	NN
cord-302047-vv5gpldi	386	16	of	of	IN
cord-302047-vv5gpldi	386	17	fitness	fitness	NN
cord-302047-vv5gpldi	386	18	following	follow	VBG
cord-302047-vv5gpldi	386	19	insertion	insertion	NN
cord-302047-vv5gpldi	386	20	of	of	IN
cord-302047-vv5gpldi	386	21	a	a	DT
cord-302047-vv5gpldi	386	22	sequence	sequence	NN
cord-302047-vv5gpldi	386	23	,	,	,
cord-302047-vv5gpldi	386	24	and	and	CC
cord-302047-vv5gpldi	386	25	their	-PRON-	PRP$
cord-302047-vv5gpldi	386	26	implications	implication	NNS
cord-302047-vv5gpldi	386	27	for	for	IN
cord-302047-vv5gpldi	386	28	sequence	sequence	NN
cord-302047-vv5gpldi	386	29	stability	stability	NN
cord-302047-vv5gpldi	386	30	.	.	.
cord-302047-vv5gpldi	387	1	We	-PRON-	PRP
cord-302047-vv5gpldi	387	2	understand	understand	VBP
cord-302047-vv5gpldi	387	3	demography	demography	NN
cord-302047-vv5gpldi	387	4	to	to	TO
cord-302047-vv5gpldi	387	5	be	be	VB
cord-302047-vv5gpldi	387	6	a	a	DT
cord-302047-vv5gpldi	387	7	description	description	NN
cord-302047-vv5gpldi	387	8	of	of	IN
cord-302047-vv5gpldi	387	9	the	the	DT
cord-302047-vv5gpldi	387	10	size	size	NN
cord-302047-vv5gpldi	387	11	and	and	CC
cord-302047-vv5gpldi	387	12	structure	structure	NN
cord-302047-vv5gpldi	387	13	of	of	IN
cord-302047-vv5gpldi	387	14	virus	virus	NN
cord-302047-vv5gpldi	387	15	populations	population	NNS
cord-302047-vv5gpldi	387	16	over	over	IN
cord-302047-vv5gpldi	387	17	time	time	NN
cord-302047-vv5gpldi	387	18	.	.	.
cord-302047-vv5gpldi	388	1	In	in	IN
cord-302047-vv5gpldi	388	2	this	this	DT
cord-302047-vv5gpldi	388	3	discussion	discussion	NN
cord-302047-vv5gpldi	388	4	we	-PRON-	PRP
cord-302047-vv5gpldi	388	5	will	will	MD
cord-302047-vv5gpldi	388	6	consider	consider	VB
cord-302047-vv5gpldi	388	7	virus	virus	NN
cord-302047-vv5gpldi	388	8	populations	population	NNS
cord-302047-vv5gpldi	388	9	that	that	WDT
cord-302047-vv5gpldi	388	10	are	be	VBP
cord-302047-vv5gpldi	388	11	divided	divide	VBN
cord-302047-vv5gpldi	388	12	into	into	IN
cord-302047-vv5gpldi	388	13	demes	deme	NNS
cord-302047-vv5gpldi	388	14	at	at	IN
cord-302047-vv5gpldi	388	15	the	the	DT
cord-302047-vv5gpldi	388	16	host	host	NN
cord-302047-vv5gpldi	388	17	or	or	CC
cord-302047-vv5gpldi	388	18	cell	cell	NN
cord-302047-vv5gpldi	388	19	level	level	NN
cord-302047-vv5gpldi	388	20	.	.	.
cord-302047-vv5gpldi	389	1	Theory	theory	NN
cord-302047-vv5gpldi	389	2	suggests	suggest	VBZ
cord-302047-vv5gpldi	389	3	that	that	IN
cord-302047-vv5gpldi	389	4	demography	demography	NN
cord-302047-vv5gpldi	389	5	could	could	MD
cord-302047-vv5gpldi	389	6	have	have	VB
cord-302047-vv5gpldi	389	7	major	major	JJ
cord-302047-vv5gpldi	389	8	implications	implication	NNS
cord-302047-vv5gpldi	389	9	for	for	IN
cord-302047-vv5gpldi	389	10	the	the	DT
cord-302047-vv5gpldi	389	11	loss	loss	NN
cord-302047-vv5gpldi	389	12	of	of	IN
cord-302047-vv5gpldi	389	13	inserted	insert	VBN
cord-302047-vv5gpldi	389	14	sequences	sequence	NNS
cord-302047-vv5gpldi	389	15	,	,	,
cord-302047-vv5gpldi	389	16	with	with	IN
cord-302047-vv5gpldi	389	17	small	small	JJ
cord-302047-vv5gpldi	389	18	population	population	NN
cord-302047-vv5gpldi	389	19	sizes	size	NNS
cord-302047-vv5gpldi	389	20	,	,	,
cord-302047-vv5gpldi	389	21	narrow	narrow	JJ
cord-302047-vv5gpldi	389	22	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	389	23	,	,	,
cord-302047-vv5gpldi	389	24	and	and	CC
cord-302047-vv5gpldi	389	25	short	short	JJ
cord-302047-vv5gpldi	389	26	time	time	NN
cord-302047-vv5gpldi	389	27	intervals	interval	NNS
cord-302047-vv5gpldi	389	28	between	between	IN
cord-302047-vv5gpldi	389	29	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	389	30	resulting	result	VBG
cord-302047-vv5gpldi	389	31	in	in	IN
cord-302047-vv5gpldi	389	32	high	high	JJ
cord-302047-vv5gpldi	389	33	sequence	sequence	NN
cord-302047-vv5gpldi	389	34	stability	stability	NN
cord-302047-vv5gpldi	389	35	.	.	.
cord-302047-vv5gpldi	390	1	Hence	hence	RB
cord-302047-vv5gpldi	390	2	,	,	,
cord-302047-vv5gpldi	390	3	the	the	DT
cord-302047-vv5gpldi	390	4	stability	stability	NN
cord-302047-vv5gpldi	390	5	of	of	IN
cord-302047-vv5gpldi	390	6	the	the	DT
cord-302047-vv5gpldi	390	7	inserted	insert	VBN
cord-302047-vv5gpldi	390	8	sequence	sequence	NN
cord-302047-vv5gpldi	390	9	can	can	MD
cord-302047-vv5gpldi	390	10	not	not	RB
cord-302047-vv5gpldi	390	11	be	be	VB
cord-302047-vv5gpldi	390	12	viewed	view	VBN
cord-302047-vv5gpldi	390	13	solely	solely	RB
cord-302047-vv5gpldi	390	14	as	as	IN
cord-302047-vv5gpldi	390	15	a	a	DT
cord-302047-vv5gpldi	390	16	property	property	NN
cord-302047-vv5gpldi	390	17	of	of	IN
cord-302047-vv5gpldi	390	18	a	a	DT
cord-302047-vv5gpldi	390	19	genome	genome	NN
cord-302047-vv5gpldi	390	20	,	,	,
cord-302047-vv5gpldi	390	21	rather	rather	RB
cord-302047-vv5gpldi	390	22	it	-PRON-	PRP
cord-302047-vv5gpldi	390	23	is	be	VBZ
cord-302047-vv5gpldi	390	24	a	a	DT
cord-302047-vv5gpldi	390	25	phenotype	phenotype	NN
cord-302047-vv5gpldi	390	26	and	and	CC
cord-302047-vv5gpldi	390	27	therefore	therefore	RB
cord-302047-vv5gpldi	390	28	depends	depend	VBZ
cord-302047-vv5gpldi	390	29	on	on	IN
cord-302047-vv5gpldi	390	30	the	the	DT
cord-302047-vv5gpldi	390	31	environment	environment	NN
cord-302047-vv5gpldi	390	32	.	.	.
cord-302047-vv5gpldi	391	1	In	in	IN
cord-302047-vv5gpldi	391	2	this	this	DT
cord-302047-vv5gpldi	391	3	section	section	NN
cord-302047-vv5gpldi	391	4	,	,	,
cord-302047-vv5gpldi	391	5	we	-PRON-	PRP
cord-302047-vv5gpldi	391	6	motivate	motivate	VBP
cord-302047-vv5gpldi	391	7	this	this	DT
cord-302047-vv5gpldi	391	8	argument	argument	NN
cord-302047-vv5gpldi	391	9	and	and	CC
cord-302047-vv5gpldi	391	10	present	present	VB
cord-302047-vv5gpldi	391	11	a	a	DT
cord-302047-vv5gpldi	391	12	simulation	simulation	NN
cord-302047-vv5gpldi	391	13	model	model	NN
cord-302047-vv5gpldi	391	14	that	that	WDT
cord-302047-vv5gpldi	391	15	highlights	highlight	VBZ
cord-302047-vv5gpldi	391	16	the	the	DT
cord-302047-vv5gpldi	391	17	effects	effect	NNS
cord-302047-vv5gpldi	391	18	of	of	IN
cord-302047-vv5gpldi	391	19	demography	demography	NN
cord-302047-vv5gpldi	391	20	on	on	IN
cord-302047-vv5gpldi	391	21	the	the	DT
cord-302047-vv5gpldi	391	22	deletion	deletion	NN
cord-302047-vv5gpldi	391	23	of	of	IN
cord-302047-vv5gpldi	391	24	inserted	insert	VBN
cord-302047-vv5gpldi	391	25	sequences	sequence	NNS
cord-302047-vv5gpldi	391	26	.	.	.
cord-302047-vv5gpldi	392	1	At	at	IN
cord-302047-vv5gpldi	392	2	its	-PRON-	PRP$
cord-302047-vv5gpldi	392	3	core	core	NN
cord-302047-vv5gpldi	392	4	,	,	,
cord-302047-vv5gpldi	392	5	the	the	DT
cord-302047-vv5gpldi	392	6	stability	stability	NN
cord-302047-vv5gpldi	392	7	of	of	IN
cord-302047-vv5gpldi	392	8	genomic	genomic	JJ
cord-302047-vv5gpldi	392	9	insertions	insertion	NNS
cord-302047-vv5gpldi	392	10	in	in	IN
cord-302047-vv5gpldi	392	11	viral	viral	JJ
cord-302047-vv5gpldi	392	12	genomes	genome	NNS
cord-302047-vv5gpldi	392	13	depends	depend	VBZ
cord-302047-vv5gpldi	392	14	on	on	IN
cord-302047-vv5gpldi	392	15	two	two	CD
cord-302047-vv5gpldi	392	16	key	key	JJ
cord-302047-vv5gpldi	392	17	factors	factor	NNS
cord-302047-vv5gpldi	392	18	.	.	.
cord-302047-vv5gpldi	393	1	First	first	RB
cord-302047-vv5gpldi	393	2	,	,	,
cord-302047-vv5gpldi	393	3	the	the	DT
cord-302047-vv5gpldi	393	4	supply	supply	NN
cord-302047-vv5gpldi	393	5	of	of	IN
cord-302047-vv5gpldi	393	6	mutations	mutation	NNS
cord-302047-vv5gpldi	393	7	removing	remove	VBG
cord-302047-vv5gpldi	393	8	the	the	DT
cord-302047-vv5gpldi	393	9	insertion	insertion	NN
cord-302047-vv5gpldi	393	10	is	be	VBZ
cord-302047-vv5gpldi	393	11	crucial	crucial	JJ
cord-302047-vv5gpldi	393	12	,	,	,
cord-302047-vv5gpldi	393	13	because	because	IN
cord-302047-vv5gpldi	393	14	selection	selection	NN
cord-302047-vv5gpldi	393	15	can	can	MD
cord-302047-vv5gpldi	393	16	only	only	RB
cord-302047-vv5gpldi	393	17	act	act	VB
cord-302047-vv5gpldi	393	18	on	on	IN
cord-302047-vv5gpldi	393	19	existing	exist	VBG
cord-302047-vv5gpldi	393	20	heritable	heritable	JJ
cord-302047-vv5gpldi	393	21	variation	variation	NN
cord-302047-vv5gpldi	393	22	.	.	.
cord-302047-vv5gpldi	394	1	Second	second	RB
cord-302047-vv5gpldi	394	2	,	,	,
cord-302047-vv5gpldi	394	3	selection	selection	NN
cord-302047-vv5gpldi	394	4	then	then	RB
cord-302047-vv5gpldi	394	5	acts	act	VBZ
cord-302047-vv5gpldi	394	6	to	to	TO
cord-302047-vv5gpldi	394	7	fix	fix	VB
cord-302047-vv5gpldi	394	8	variants	variant	NNS
cord-302047-vv5gpldi	394	9	with	with	IN
cord-302047-vv5gpldi	394	10	the	the	DT
cord-302047-vv5gpldi	394	11	inserted	insert	VBN
cord-302047-vv5gpldi	394	12	sequence	sequence	NN
cord-302047-vv5gpldi	394	13	removed	remove	VBN
cord-302047-vv5gpldi	394	14	.	.	.
cord-302047-vv5gpldi	395	1	All	all	DT
cord-302047-vv5gpldi	395	2	other	other	JJ
cord-302047-vv5gpldi	395	3	things	thing	NNS
cord-302047-vv5gpldi	395	4	equal	equal	JJ
cord-302047-vv5gpldi	395	5	,	,	,
cord-302047-vv5gpldi	395	6	the	the	DT
cord-302047-vv5gpldi	395	7	larger	large	JJR
cord-302047-vv5gpldi	395	8	the	the	DT
cord-302047-vv5gpldi	395	9	supply	supply	NN
cord-302047-vv5gpldi	395	10	of	of	IN
cord-302047-vv5gpldi	395	11	mutations	mutation	NNS
cord-302047-vv5gpldi	395	12	that	that	WDT
cord-302047-vv5gpldi	395	13	remove	remove	VBP
cord-302047-vv5gpldi	395	14	the	the	DT
cord-302047-vv5gpldi	395	15	insertion	insertion	NN
cord-302047-vv5gpldi	395	16	and	and	CC
cord-302047-vv5gpldi	395	17	the	the	DT
cord-302047-vv5gpldi	395	18	larger	large	JJR
cord-302047-vv5gpldi	395	19	the	the	DT
cord-302047-vv5gpldi	395	20	selection	selection	NN
cord-302047-vv5gpldi	395	21	coefficients	coefficient	NNS
cord-302047-vv5gpldi	395	22	of	of	IN
cord-302047-vv5gpldi	395	23	variants	variant	NNS
cord-302047-vv5gpldi	395	24	with	with	IN
cord-302047-vv5gpldi	395	25	the	the	DT
cord-302047-vv5gpldi	395	26	insert	insert	NN
cord-302047-vv5gpldi	395	27	removed	remove	VBN
cord-302047-vv5gpldi	395	28	,	,	,
cord-302047-vv5gpldi	395	29	the	the	DT
cord-302047-vv5gpldi	395	30	less	less	RBR
cord-302047-vv5gpldi	395	31	stable	stable	JJ
cord-302047-vv5gpldi	395	32	the	the	DT
cord-302047-vv5gpldi	395	33	insertion	insertion	NN
cord-302047-vv5gpldi	395	34	will	will	MD
cord-302047-vv5gpldi	395	35	be	be	VB
cord-302047-vv5gpldi	395	36	.	.	.
cord-302047-vv5gpldi	396	1	The	the	DT
cord-302047-vv5gpldi	396	2	interplay	interplay	NN
cord-302047-vv5gpldi	396	3	between	between	IN
cord-302047-vv5gpldi	396	4	mutation	mutation	NN
cord-302047-vv5gpldi	396	5	and	and	CC
cord-302047-vv5gpldi	396	6	selection	selection	NN
cord-302047-vv5gpldi	396	7	will	will	MD
cord-302047-vv5gpldi	396	8	govern	govern	VB
cord-302047-vv5gpldi	396	9	the	the	DT
cord-302047-vv5gpldi	396	10	stability	stability	NN
cord-302047-vv5gpldi	396	11	of	of	IN
cord-302047-vv5gpldi	396	12	genomic	genomic	JJ
cord-302047-vv5gpldi	396	13	inserts	insert	NNS
cord-302047-vv5gpldi	396	14	,	,	,
cord-302047-vv5gpldi	396	15	and	and	CC
cord-302047-vv5gpldi	396	16	in	in	IN
cord-302047-vv5gpldi	396	17	many	many	JJ
cord-302047-vv5gpldi	396	18	cases	case	NNS
cord-302047-vv5gpldi	396	19	demography	demography	NN
cord-302047-vv5gpldi	396	20	has	have	VBZ
cord-302047-vv5gpldi	396	21	an	an	DT
cord-302047-vv5gpldi	396	22	important	important	JJ
cord-302047-vv5gpldi	396	23	role	role	NN
cord-302047-vv5gpldi	396	24	in	in	IN
cord-302047-vv5gpldi	396	25	shaping	shape	VBG
cord-302047-vv5gpldi	396	26	this	this	DT
cord-302047-vv5gpldi	396	27	interplay	interplay	NN
cord-302047-vv5gpldi	396	28	.	.	.
cord-302047-vv5gpldi	397	1	For	for	IN
cord-302047-vv5gpldi	397	2	example	example	NN
cord-302047-vv5gpldi	397	3	,	,	,
cord-302047-vv5gpldi	397	4	low	low	JJ
cord-302047-vv5gpldi	397	5	fitness	fitness	NN
cord-302047-vv5gpldi	397	6	can	can	MD
cord-302047-vv5gpldi	397	7	lead	lead	VB
cord-302047-vv5gpldi	397	8	to	to	IN
cord-302047-vv5gpldi	397	9	small	small	JJ
cord-302047-vv5gpldi	397	10	population	population	NN
cord-302047-vv5gpldi	397	11	sizes	size	NNS
cord-302047-vv5gpldi	397	12	,	,	,
cord-302047-vv5gpldi	397	13	which	which	WDT
cord-302047-vv5gpldi	397	14	in	in	IN
cord-302047-vv5gpldi	397	15	turn	turn	NN
cord-302047-vv5gpldi	397	16	will	will	MD
cord-302047-vv5gpldi	397	17	limit	limit	VB
cord-302047-vv5gpldi	397	18	the	the	DT
cord-302047-vv5gpldi	397	19	mutation	mutation	NN
cord-302047-vv5gpldi	397	20	supply	supply	NN
cord-302047-vv5gpldi	397	21	(	(	-LRB-
cord-302047-vv5gpldi	397	22	Chao	Chao	NNP
cord-302047-vv5gpldi	397	23	1990	1990	CD
cord-302047-vv5gpldi	397	24	;	;	:
cord-302047-vv5gpldi	397	25	Lynch	Lynch	NNP
cord-302047-vv5gpldi	397	26	and	and	CC
cord-302047-vv5gpldi	397	27	Gabriel	Gabriel	NNP
cord-302047-vv5gpldi	397	28	1990	1990	CD
cord-302047-vv5gpldi	397	29	)	)	-RRB-
cord-302047-vv5gpldi	397	30	.	.	.
cord-302047-vv5gpldi	398	1	A	a	DT
cord-302047-vv5gpldi	398	2	high	high	JJ
cord-302047-vv5gpldi	398	3	-	-	HYPH
cord-302047-vv5gpldi	398	4	cost	cost	NN
cord-302047-vv5gpldi	398	5	inserted	insert	VBN
cord-302047-vv5gpldi	398	6	sequence	sequence	NN
cord-302047-vv5gpldi	398	7	might	may	MD
cord-302047-vv5gpldi	398	8	therefore	therefore	RB
cord-302047-vv5gpldi	398	9	limit	limit	VB
cord-302047-vv5gpldi	398	10	viral	viral	JJ
cord-302047-vv5gpldi	398	11	evolvability	evolvability	NN
cord-302047-vv5gpldi	398	12	,	,	,
cord-302047-vv5gpldi	398	13	thereby	thereby	RB
cord-302047-vv5gpldi	398	14	promoting	promote	VBG
cord-302047-vv5gpldi	398	15	its	-PRON-	PRP$
cord-302047-vv5gpldi	398	16	own	own	JJ
cord-302047-vv5gpldi	398	17	stability	stability	NN
cord-302047-vv5gpldi	398	18	.	.	.
cord-302047-vv5gpldi	399	1	Genetic	genetic	JJ
cord-302047-vv5gpldi	399	2	drift	drift	NN
cord-302047-vv5gpldi	399	3	can	can	MD
cord-302047-vv5gpldi	399	4	also	also	RB
cord-302047-vv5gpldi	399	5	play	play	VB
cord-302047-vv5gpldi	399	6	an	an	DT
cord-302047-vv5gpldi	399	7	important	important	JJ
cord-302047-vv5gpldi	399	8	role	role	NN
cord-302047-vv5gpldi	399	9	in	in	IN
cord-302047-vv5gpldi	399	10	determining	determine	VBG
cord-302047-vv5gpldi	399	11	the	the	DT
cord-302047-vv5gpldi	399	12	stability	stability	NN
cord-302047-vv5gpldi	399	13	of	of	IN
cord-302047-vv5gpldi	399	14	inserted	insert	VBN
cord-302047-vv5gpldi	399	15	sequences	sequence	NNS
cord-302047-vv5gpldi	399	16	,	,	,
cord-302047-vv5gpldi	399	17	as	as	IN
cord-302047-vv5gpldi	399	18	inserts	insert	NNS
cord-302047-vv5gpldi	399	19	can	can	MD
cord-302047-vv5gpldi	399	20	have	have	VB
cord-302047-vv5gpldi	399	21	high	high	JJ
cord-302047-vv5gpldi	399	22	stability	stability	NN
cord-302047-vv5gpldi	399	23	if	if	IN
cord-302047-vv5gpldi	399	24	a	a	DT
cord-302047-vv5gpldi	399	25	viral	viral	JJ
cord-302047-vv5gpldi	399	26	population	population	NN
cord-302047-vv5gpldi	399	27	regularly	regularly	RB
cord-302047-vv5gpldi	399	28	passes	pass	VBZ
cord-302047-vv5gpldi	399	29	through	through	IN
cord-302047-vv5gpldi	399	30	population	population	NN
cord-302047-vv5gpldi	399	31	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	399	32	.	.	.
cord-302047-vv5gpldi	400	1	This	this	DT
cord-302047-vv5gpldi	400	2	idea	idea	NN
cord-302047-vv5gpldi	400	3	is	be	VBZ
cord-302047-vv5gpldi	400	4	inspired	inspire	VBN
cord-302047-vv5gpldi	400	5	by	by	IN
cord-302047-vv5gpldi	400	6	the	the	DT
cord-302047-vv5gpldi	400	7	empirical	empirical	JJ
cord-302047-vv5gpldi	400	8	observation	observation	NN
cord-302047-vv5gpldi	400	9	that	that	IN
cord-302047-vv5gpldi	400	10	a	a	DT
cord-302047-vv5gpldi	400	11	group	group	NN
cord-302047-vv5gpldi	400	12	IV	IV	NNP
cord-302047-vv5gpldi	400	13	plant	plant	NN
cord-302047-vv5gpldi	400	14	virus	virus	NN
cord-302047-vv5gpldi	400	15	appears	appear	VBZ
cord-302047-vv5gpldi	400	16	to	to	TO
cord-302047-vv5gpldi	400	17	be	be	VB
cord-302047-vv5gpldi	400	18	stable	stable	JJ
cord-302047-vv5gpldi	400	19	when	when	WRB
cord-302047-vv5gpldi	400	20	shortduration	shortduration	NN
cord-302047-vv5gpldi	400	21	passages	passage	NNS
cord-302047-vv5gpldi	400	22	are	be	VBP
cord-302047-vv5gpldi	400	23	used	use	VBN
cord-302047-vv5gpldi	400	24	,	,	,
cord-302047-vv5gpldi	400	25	but	but	CC
cord-302047-vv5gpldi	400	26	not	not	RB
cord-302047-vv5gpldi	400	27	in	in	IN
cord-302047-vv5gpldi	400	28	long	long	JJ
cord-302047-vv5gpldi	400	29	-	-	HYPH
cord-302047-vv5gpldi	400	30	duration	duration	NN
cord-302047-vv5gpldi	400	31	passages	passage	NNS
cord-302047-vv5gpldi	401	1	Zwart	Zwart	NNP
cord-302047-vv5gpldi	401	2	et	et	NNP
cord-302047-vv5gpldi	401	3	al	al	NNP
cord-302047-vv5gpldi	401	4	.	.	.
cord-302047-vv5gpldi	402	1	2014	2014	CD
cord-302047-vv5gpldi	402	2	;	;	:
cord-302047-vv5gpldi	402	3	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	402	4	et	et	NNP
cord-302047-vv5gpldi	402	5	al	al	NNP
cord-302047-vv5gpldi	402	6	.	.	.
cord-302047-vv5gpldi	402	7	2016	2016	CD
cord-302047-vv5gpldi	403	1	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	403	2	et	et	NNP
cord-302047-vv5gpldi	403	3	al	al	NNP
cord-302047-vv5gpldi	403	4	.	.	NNP
cord-302047-vv5gpldi	403	5	,	,	,
cord-302047-vv5gpldi	403	6	2018	2018	CD
cord-302047-vv5gpldi	403	7	.	.	.
cord-302047-vv5gpldi	404	1	Viruses	virus	NNS
cord-302047-vv5gpldi	404	2	pass	pass	VBP
cord-302047-vv5gpldi	404	3	through	through	IN
cord-302047-vv5gpldi	404	4	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	404	5	at	at	IN
cord-302047-vv5gpldi	404	6	many	many	JJ
cord-302047-vv5gpldi	404	7	points	point	NNS
cord-302047-vv5gpldi	404	8	during	during	IN
cord-302047-vv5gpldi	404	9	infection	infection	NN
cord-302047-vv5gpldi	404	10	,	,	,
cord-302047-vv5gpldi	404	11	in	in	IN
cord-302047-vv5gpldi	404	12	vitro	vitro	FW
cord-302047-vv5gpldi	404	13	and	and	CC
cord-302047-vv5gpldi	404	14	in	in	IN
cord-302047-vv5gpldi	404	15	vivo	vivo	NN
cord-302047-vv5gpldi	405	1	(	(	-LRB-
cord-302047-vv5gpldi	405	2	Zwart	Zwart	NNP
cord-302047-vv5gpldi	405	3	and	and	CC
cord-302047-vv5gpldi	405	4	Elena	Elena	NNP
cord-302047-vv5gpldi	405	5	2015	2015	CD
cord-302047-vv5gpldi	405	6	)	)	-RRB-
cord-302047-vv5gpldi	405	7	,	,	,
cord-302047-vv5gpldi	405	8	it	-PRON-	PRP
cord-302047-vv5gpldi	405	9	is	be	VBZ
cord-302047-vv5gpldi	405	10	therefore	therefore	RB
cord-302047-vv5gpldi	405	11	important	important	JJ
cord-302047-vv5gpldi	405	12	to	to	TO
cord-302047-vv5gpldi	405	13	consider	consider	VB
cord-302047-vv5gpldi	405	14	these	these	DT
cord-302047-vv5gpldi	405	15	effects	effect	NNS
cord-302047-vv5gpldi	405	16	.	.	.
cord-302047-vv5gpldi	406	1	Even	even	RB
cord-302047-vv5gpldi	406	2	if	if	IN
cord-302047-vv5gpldi	406	3	there	there	EX
cord-302047-vv5gpldi	406	4	is	be	VBZ
cord-302047-vv5gpldi	406	5	a	a	DT
cord-302047-vv5gpldi	406	6	large	large	JJ
cord-302047-vv5gpldi	406	7	supply	supply	NN
cord-302047-vv5gpldi	406	8	of	of	IN
cord-302047-vv5gpldi	406	9	deletions	deletion	NNS
cord-302047-vv5gpldi	406	10	and	and	CC
cord-302047-vv5gpldi	406	11	strong	strong	JJ
cord-302047-vv5gpldi	406	12	selection	selection	NN
cord-302047-vv5gpldi	406	13	for	for	IN
cord-302047-vv5gpldi	406	14	the	the	DT
cord-302047-vv5gpldi	406	15	deletion	deletion	NN
cord-302047-vv5gpldi	406	16	mutant	mutant	NN
cord-302047-vv5gpldi	406	17	,	,	,
cord-302047-vv5gpldi	406	18	if	if	IN
cord-302047-vv5gpldi	406	19	deletion	deletion	NN
cord-302047-vv5gpldi	406	20	mutants	mutant	NNS
cord-302047-vv5gpldi	406	21	fail	fail	VBP
cord-302047-vv5gpldi	406	22	to	to	TO
cord-302047-vv5gpldi	406	23	reach	reach	VB
cord-302047-vv5gpldi	406	24	a	a	DT
cord-302047-vv5gpldi	406	25	frequency	frequency	NN
cord-302047-vv5gpldi	406	26	!	!	.
cord-302047-vv5gpldi	407	1	/a	/a	NNP
cord-302047-vv5gpldi	407	2	,	,	,
cord-302047-vv5gpldi	407	3	where	where	WRB
cord-302047-vv5gpldi	407	4	a	a	DT
cord-302047-vv5gpldi	407	5	is	be	VBZ
cord-302047-vv5gpldi	407	6	the	the	DT
cord-302047-vv5gpldi	407	7	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	407	8	size	size	NN
cord-302047-vv5gpldi	407	9	,	,	,
cord-302047-vv5gpldi	407	10	they	-PRON-	PRP
cord-302047-vv5gpldi	407	11	are	be	VBP
cord-302047-vv5gpldi	407	12	unlikely	unlikely	JJ
cord-302047-vv5gpldi	407	13	to	to	TO
cord-302047-vv5gpldi	407	14	pass	pass	VB
cord-302047-vv5gpldi	407	15	through	through	IN
cord-302047-vv5gpldi	407	16	the	the	DT
cord-302047-vv5gpldi	407	17	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	407	18	(	(	-LRB-
cord-302047-vv5gpldi	407	19	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	407	20	et	et	NNP
cord-302047-vv5gpldi	407	21	al	al	NNP
cord-302047-vv5gpldi	407	22	.	.	.
cord-302047-vv5gpldi	408	1	2016	2016	CD
cord-302047-vv5gpldi	409	1	(	(	-LRB-
cord-302047-vv5gpldi	409	2	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	409	3	et	et	NNP
cord-302047-vv5gpldi	409	4	al	al	NNP
cord-302047-vv5gpldi	409	5	.	.	NNP
cord-302047-vv5gpldi	409	6	,	,	,
cord-302047-vv5gpldi	409	7	2018	2018	CD
cord-302047-vv5gpldi	409	8	.	.	.
cord-302047-vv5gpldi	410	1	This	this	DT
cord-302047-vv5gpldi	410	2	leads	lead	VBZ
cord-302047-vv5gpldi	410	3	to	to	IN
cord-302047-vv5gpldi	410	4	a	a	DT
cord-302047-vv5gpldi	410	5	'	'	``
cord-302047-vv5gpldi	410	6	resetting	resetting	NN
cord-302047-vv5gpldi	410	7	'	'	''
cord-302047-vv5gpldi	410	8	of	of	IN
cord-302047-vv5gpldi	410	9	the	the	DT
cord-302047-vv5gpldi	410	10	virus	virus	NN
cord-302047-vv5gpldi	410	11	population	population	NN
cord-302047-vv5gpldi	410	12	by	by	IN
cord-302047-vv5gpldi	410	13	each	each	DT
cord-302047-vv5gpldi	410	14	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	410	15	event	event	NN
cord-302047-vv5gpldi	410	16	(	(	-LRB-
cord-302047-vv5gpldi	410	17	Fig	Fig	NNP
cord-302047-vv5gpldi	410	18	.	.	.
cord-302047-vv5gpldi	410	19	1	1	CD
cord-302047-vv5gpldi	410	20	)	)	-RRB-
cord-302047-vv5gpldi	410	21	,	,	,
cord-302047-vv5gpldi	410	22	effectively	effectively	RB
cord-302047-vv5gpldi	410	23	resulting	result	VBG
cord-302047-vv5gpldi	410	24	in	in	IN
cord-302047-vv5gpldi	410	25	high	high	JJ
cord-302047-vv5gpldi	410	26	stability	stability	NN
cord-302047-vv5gpldi	410	27	of	of	IN
cord-302047-vv5gpldi	410	28	the	the	DT
cord-302047-vv5gpldi	410	29	inserted	insert	VBN
cord-302047-vv5gpldi	410	30	sequences	sequence	NNS
cord-302047-vv5gpldi	410	31	(	(	-LRB-
cord-302047-vv5gpldi	410	32	Box	Box	NNP
cord-302047-vv5gpldi	410	33	1	1	CD
cord-302047-vv5gpldi	410	34	,	,	,
cord-302047-vv5gpldi	410	35	see	see	VB
cord-302047-vv5gpldi	410	36	also	also	RB
cord-302047-vv5gpldi	410	37	Fig	Fig	NNP
cord-302047-vv5gpldi	410	38	.	.	NNP
cord-302047-vv5gpldi	410	39	2	2	CD
cord-302047-vv5gpldi	410	40	)	)	-RRB-
cord-302047-vv5gpldi	410	41	.	.	.
cord-302047-vv5gpldi	411	1	Short	short	JJ
cord-302047-vv5gpldi	411	2	passages	passage	NNS
cord-302047-vv5gpldi	411	3	shorten	shorten	VBP
cord-302047-vv5gpldi	411	4	the	the	DT
cord-302047-vv5gpldi	411	5	time	time	NN
cord-302047-vv5gpldi	411	6	for	for	IN
cord-302047-vv5gpldi	411	7	deletion	deletion	NN
cord-302047-vv5gpldi	411	8	mutants	mutant	NNS
cord-302047-vv5gpldi	411	9	to	to	TO
cord-302047-vv5gpldi	411	10	reach	reach	VB
cord-302047-vv5gpldi	411	11	the	the	DT
cord-302047-vv5gpldi	411	12	frequency	frequency	NN
cord-302047-vv5gpldi	411	13	1	1	CD
cord-302047-vv5gpldi	411	14	/	/	SYM
cord-302047-vv5gpldi	411	15	a	a	NN
cord-302047-vv5gpldi	411	16	,	,	,
cord-302047-vv5gpldi	411	17	making	make	VBG
cord-302047-vv5gpldi	411	18	it	-PRON-	PRP
cord-302047-vv5gpldi	411	19	more	more	RBR
cord-302047-vv5gpldi	411	20	difficult	difficult	JJ
cord-302047-vv5gpldi	411	21	for	for	IN
cord-302047-vv5gpldi	411	22	these	these	DT
cord-302047-vv5gpldi	411	23	variants	variant	NNS
cord-302047-vv5gpldi	411	24	to	to	TO
cord-302047-vv5gpldi	411	25	pass	pass	VB
cord-302047-vv5gpldi	411	26	through	through	IN
cord-302047-vv5gpldi	411	27	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	411	28	and	and	CC
cord-302047-vv5gpldi	411	29	hereby	hereby	RB
cord-302047-vv5gpldi	411	30	promoting	promote	VBG
cord-302047-vv5gpldi	411	31	insert	insert	JJ
cord-302047-vv5gpldi	411	32	stability	stability	NN
cord-302047-vv5gpldi	411	33	.	.	.
cord-302047-vv5gpldi	412	1	It	-PRON-	PRP
cord-302047-vv5gpldi	412	2	is	be	VBZ
cord-302047-vv5gpldi	412	3	important	important	JJ
cord-302047-vv5gpldi	412	4	to	to	TO
cord-302047-vv5gpldi	412	5	remember	remember	VB
cord-302047-vv5gpldi	412	6	that	that	IN
cord-302047-vv5gpldi	412	7	assays	assay	NNS
cord-302047-vv5gpldi	412	8	for	for	IN
cord-302047-vv5gpldi	412	9	detecting	detect	VBG
cord-302047-vv5gpldi	412	10	deletion	deletion	NN
cord-302047-vv5gpldi	412	11	mutants	mutant	NNS
cord-302047-vv5gpldi	412	12	,	,	,
cord-302047-vv5gpldi	412	13	such	such	JJ
cord-302047-vv5gpldi	412	14	as	as	IN
cord-302047-vv5gpldi	412	15	deep	deep	JJ
cord-302047-vv5gpldi	412	16	sequencing	sequencing	NN
cord-302047-vv5gpldi	412	17	or	or	CC
cord-302047-vv5gpldi	412	18	the	the	DT
cord-302047-vv5gpldi	412	19	polymerase	polymerase	NN
cord-302047-vv5gpldi	412	20	chain	chain	NN
cord-302047-vv5gpldi	412	21	reaction	reaction	NN
cord-302047-vv5gpldi	412	22	,	,	,
cord-302047-vv5gpldi	412	23	do	do	VBP
cord-302047-vv5gpldi	412	24	have	have	VB
cord-302047-vv5gpldi	412	25	limited	limit	VBN
cord-302047-vv5gpldi	412	26	sensitivity	sensitivity	NN
cord-302047-vv5gpldi	412	27	.	.	.
cord-302047-vv5gpldi	413	1	Deletions	deletion	NNS
cord-302047-vv5gpldi	413	2	may	may	MD
cord-302047-vv5gpldi	413	3	therefore	therefore	RB
cord-302047-vv5gpldi	413	4	also	also	RB
cord-302047-vv5gpldi	413	5	be	be	VB
cord-302047-vv5gpldi	413	6	detected	detect	VBN
cord-302047-vv5gpldi	413	7	more	more	RBR
cord-302047-vv5gpldi	413	8	readily	readily	RB
cord-302047-vv5gpldi	413	9	in	in	IN
cord-302047-vv5gpldi	413	10	longer	long	JJR
cord-302047-vv5gpldi	413	11	passages	passage	NNS
cord-302047-vv5gpldi	413	12	,	,	,
cord-302047-vv5gpldi	413	13	whilst	whilst	IN
cord-302047-vv5gpldi	413	14	low	low	JJ
cord-302047-vv5gpldi	413	15	frequency	frequency	NN
cord-302047-vv5gpldi	413	16	mutations	mutation	NNS
cord-302047-vv5gpldi	413	17	that	that	WDT
cord-302047-vv5gpldi	413	18	will	will	MD
cord-302047-vv5gpldi	413	19	be	be	VB
cord-302047-vv5gpldi	413	20	purged	purge	VBN
cord-302047-vv5gpldi	413	21	by	by	IN
cord-302047-vv5gpldi	413	22	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	413	23	may	may	MD
cord-302047-vv5gpldi	413	24	not	not	RB
cord-302047-vv5gpldi	413	25	be	be	VB
cord-302047-vv5gpldi	413	26	detected	detect	VBN
cord-302047-vv5gpldi	413	27	(	(	-LRB-
cord-302047-vv5gpldi	413	28	Bull	Bull	NNP
cord-302047-vv5gpldi	413	29	,	,	,
cord-302047-vv5gpldi	413	30	Nuismer	Nuismer	NNP
cord-302047-vv5gpldi	413	31	,	,	,
cord-302047-vv5gpldi	413	32	and	and	CC
cord-302047-vv5gpldi	413	33	Antia	Antia	NNP
cord-302047-vv5gpldi	413	34	2019	2019	CD
cord-302047-vv5gpldi	413	35	)	)	-RRB-
cord-302047-vv5gpldi	413	36	.	.	.
cord-302047-vv5gpldi	414	1	Demography	demography	NN
cord-302047-vv5gpldi	414	2	can	can	MD
cord-302047-vv5gpldi	414	3	also	also	RB
cord-302047-vv5gpldi	414	4	modulate	modulate	VB
cord-302047-vv5gpldi	414	5	the	the	DT
cord-302047-vv5gpldi	414	6	strength	strength	NN
cord-302047-vv5gpldi	414	7	of	of	IN
cord-302047-vv5gpldi	414	8	selection	selection	NN
cord-302047-vv5gpldi	414	9	itself	-PRON-	PRP
cord-302047-vv5gpldi	414	10	.	.	.
cord-302047-vv5gpldi	415	1	The	the	DT
cord-302047-vv5gpldi	415	2	MOI	MOI	NNP
cord-302047-vv5gpldi	415	3	(	(	-LRB-
cord-302047-vv5gpldi	415	4	cellular	cellular	JJ
cord-302047-vv5gpldi	415	5	multiplicity	multiplicity	NN
cord-302047-vv5gpldi	415	6	of	of	IN
cord-302047-vv5gpldi	415	7	infection	infection	NN
cord-302047-vv5gpldi	415	8	)	)	-RRB-
cord-302047-vv5gpldi	415	9	is	be	VBZ
cord-302047-vv5gpldi	415	10	a	a	DT
cord-302047-vv5gpldi	415	11	key	key	JJ
cord-302047-vv5gpldi	415	12	demographic	demographic	JJ
cord-302047-vv5gpldi	415	13	parameter	parameter	NN
cord-302047-vv5gpldi	415	14	at	at	IN
cord-302047-vv5gpldi	415	15	the	the	DT
cord-302047-vv5gpldi	415	16	cellular	cellular	JJ
cord-302047-vv5gpldi	415	17	level	level	NN
cord-302047-vv5gpldi	415	18	,	,	,
cord-302047-vv5gpldi	415	19	as	as	IN
cord-302047-vv5gpldi	415	20	it	-PRON-	PRP
cord-302047-vv5gpldi	415	21	describes	describe	VBZ
cord-302047-vv5gpldi	415	22	the	the	DT
cord-302047-vv5gpldi	415	23	number	number	NN
cord-302047-vv5gpldi	415	24	of	of	IN
cord-302047-vv5gpldi	415	25	virus	virus	NN
cord-302047-vv5gpldi	415	26	particles	particle	NNS
cord-302047-vv5gpldi	415	27	infecting	infect	VBG
cord-302047-vv5gpldi	415	28	a	a	DT
cord-302047-vv5gpldi	415	29	cell	cell	NN
cord-302047-vv5gpldi	415	30	.	.	.
cord-302047-vv5gpldi	416	1	If	if	IN
cord-302047-vv5gpldi	416	2	an	an	DT
cord-302047-vv5gpldi	416	3	inserted	insert	VBN
cord-302047-vv5gpldi	416	4	sequence	sequence	NN
cord-302047-vv5gpldi	416	5	affects	affect	VBZ
cord-302047-vv5gpldi	416	6	viral	viral	JJ
cord-302047-vv5gpldi	416	7	fitness	fitness	NN
cord-302047-vv5gpldi	416	8	in	in	IN
cord-302047-vv5gpldi	416	9	trans	trans	NNP
cord-302047-vv5gpldi	416	10	at	at	IN
cord-302047-vv5gpldi	416	11	the	the	DT
cord-302047-vv5gpldi	416	12	within	within	JJ
cord-302047-vv5gpldi	416	13	cell	cell	NN
cord-302047-vv5gpldi	416	14	level	level	NN
cord-302047-vv5gpldi	416	15	-	-	:
cord-302047-vv5gpldi	416	16	for	for	IN
cord-302047-vv5gpldi	416	17	example	example	NN
cord-302047-vv5gpldi	416	18	by	by	IN
cord-302047-vv5gpldi	416	19	being	be	VBG
cord-302047-vv5gpldi	416	20	toxic	toxic	JJ
cord-302047-vv5gpldi	416	21	-	-	:
cord-302047-vv5gpldi	416	22	then	then	RB
cord-302047-vv5gpldi	416	23	the	the	DT
cord-302047-vv5gpldi	416	24	MOI	MOI	NNP
cord-302047-vv5gpldi	416	25	will	will	MD
cord-302047-vv5gpldi	416	26	determine	determine	VB
cord-302047-vv5gpldi	416	27	whether	whether	IN
cord-302047-vv5gpldi	416	28	there	there	EX
cord-302047-vv5gpldi	416	29	can	can	MD
cord-302047-vv5gpldi	416	30	be	be	VB
cord-302047-vv5gpldi	416	31	selection	selection	NN
cord-302047-vv5gpldi	416	32	(	(	-LRB-
cord-302047-vv5gpldi	416	33	Miyashita	Miyashita	NNP
cord-302047-vv5gpldi	416	34	and	and	CC
cord-302047-vv5gpldi	416	35	Kishino	Kishino	NNP
cord-302047-vv5gpldi	416	36	2010	2010	CD
cord-302047-vv5gpldi	416	37	)	)	-RRB-
cord-302047-vv5gpldi	416	38	.	.	.
cord-302047-vv5gpldi	417	1	At	at	IN
cord-302047-vv5gpldi	417	2	high	high	JJ
cord-302047-vv5gpldi	417	3	MOIs	mois	NN
cord-302047-vv5gpldi	417	4	there	there	RB
cord-302047-vv5gpldi	417	5	will	will	MD
cord-302047-vv5gpldi	417	6	be	be	VB
cord-302047-vv5gpldi	417	7	no	no	DT
cord-302047-vv5gpldi	417	8	selection	selection	NN
cord-302047-vv5gpldi	417	9	,	,	,
cord-302047-vv5gpldi	417	10	because	because	IN
cord-302047-vv5gpldi	417	11	the	the	DT
cord-302047-vv5gpldi	417	12	toxin	toxin	NN
cord-302047-vv5gpldi	417	13	is	be	VBZ
cord-302047-vv5gpldi	417	14	produced	produce	VBN
cord-302047-vv5gpldi	417	15	in	in	IN
cord-302047-vv5gpldi	417	16	all	all	DT
cord-302047-vv5gpldi	417	17	cells	cell	NNS
cord-302047-vv5gpldi	417	18	and	and	CC
cord-302047-vv5gpldi	417	19	affects	affect	VBZ
cord-302047-vv5gpldi	417	20	the	the	DT
cord-302047-vv5gpldi	417	21	replication	replication	NN
cord-302047-vv5gpldi	417	22	of	of	IN
cord-302047-vv5gpldi	417	23	both	both	DT
cord-302047-vv5gpldi	417	24	producers	producer	NNS
cord-302047-vv5gpldi	417	25	and	and	CC
cord-302047-vv5gpldi	417	26	nonproducers	nonproducer	NNS
cord-302047-vv5gpldi	417	27	of	of	IN
cord-302047-vv5gpldi	417	28	the	the	DT
cord-302047-vv5gpldi	417	29	toxin	toxin	NN
cord-302047-vv5gpldi	417	30	(	(	-LRB-
cord-302047-vv5gpldi	417	31	Fig	Fig	NNP
cord-302047-vv5gpldi	417	32	.	.	.
cord-302047-vv5gpldi	417	33	3	3	CD
cord-302047-vv5gpldi	417	34	)	)	-RRB-
cord-302047-vv5gpldi	417	35	.	.	.
cord-302047-vv5gpldi	418	1	An	an	DT
cord-302047-vv5gpldi	418	2	interesting	interesting	JJ
cord-302047-vv5gpldi	418	3	conundrum	conundrum	NN
cord-302047-vv5gpldi	418	4	is	be	VBZ
cord-302047-vv5gpldi	418	5	that	that	IN
cord-302047-vv5gpldi	418	6	high	high	JJ
cord-302047-vv5gpldi	418	7	MOIs	mois	NN
cord-302047-vv5gpldi	418	8	also	also	RB
cord-302047-vv5gpldi	418	9	tend	tend	VBP
cord-302047-vv5gpldi	418	10	to	to	TO
cord-302047-vv5gpldi	418	11	promote	promote	VB
cord-302047-vv5gpldi	418	12	the	the	DT
cord-302047-vv5gpldi	418	13	evolution	evolution	NN
cord-302047-vv5gpldi	418	14	of	of	IN
cord-302047-vv5gpldi	418	15	DI	DI	NNP
cord-302047-vv5gpldi	418	16	viruses	virus	NNS
cord-302047-vv5gpldi	418	17	(	(	-LRB-
cord-302047-vv5gpldi	418	18	Huang	Huang	NNP
cord-302047-vv5gpldi	418	19	1973	1973	CD
cord-302047-vv5gpldi	418	20	)	)	-RRB-
cord-302047-vv5gpldi	418	21	due	due	IN
cord-302047-vv5gpldi	418	22	to	to	IN
cord-302047-vv5gpldi	418	23	within	within	IN
cord-302047-vv5gpldi	418	24	-	-	HYPH
cord-302047-vv5gpldi	418	25	cell	cell	NN
cord-302047-vv5gpldi	418	26	selection	selection	NN
cord-302047-vv5gpldi	418	27	,	,	,
cord-302047-vv5gpldi	418	28	and	and	CC
cord-302047-vv5gpldi	418	29	hence	hence	RB
cord-302047-vv5gpldi	418	30	these	these	DT
cord-302047-vv5gpldi	418	31	two	two	CD
cord-302047-vv5gpldi	418	32	effects	effect	NNS
cord-302047-vv5gpldi	418	33	must	must	MD
cord-302047-vv5gpldi	418	34	be	be	VB
cord-302047-vv5gpldi	418	35	weighed	weigh	VBN
cord-302047-vv5gpldi	418	36	accordingly	accordingly	RB
cord-302047-vv5gpldi	418	37	.	.	.
cord-302047-vv5gpldi	419	1	In	in	IN
cord-302047-vv5gpldi	419	2	this	this	DT
cord-302047-vv5gpldi	419	3	review	review	NN
cord-302047-vv5gpldi	419	4	,	,	,
cord-302047-vv5gpldi	419	5	we	-PRON-	PRP
cord-302047-vv5gpldi	419	6	considered	consider	VBD
cord-302047-vv5gpldi	419	7	only	only	RB
cord-302047-vv5gpldi	419	8	a	a	DT
cord-302047-vv5gpldi	419	9	few	few	JJ
cord-302047-vv5gpldi	419	10	cases	case	NNS
cord-302047-vv5gpldi	419	11	in	in	IN
cord-302047-vv5gpldi	419	12	which	which	WDT
cord-302047-vv5gpldi	419	13	inserted	insert	VBD
cord-302047-vv5gpldi	419	14	sequences	sequence	NNS
cord-302047-vv5gpldi	419	15	potentially	potentially	RB
cord-302047-vv5gpldi	419	16	could	could	MD
cord-302047-vv5gpldi	419	17	have	have	VB
cord-302047-vv5gpldi	419	18	beneficial	beneficial	JJ
cord-302047-vv5gpldi	419	19	effects	effect	NNS
cord-302047-vv5gpldi	419	20	on	on	IN
cord-302047-vv5gpldi	419	21	a	a	DT
cord-302047-vv5gpldi	419	22	virus	virus	NN
cord-302047-vv5gpldi	419	23	(	(	-LRB-
cord-302047-vv5gpldi	419	24	Thomas	Thomas	NNP
cord-302047-vv5gpldi	419	25	,	,	,
cord-302047-vv5gpldi	419	26	Cameron	Cameron	NNP
cord-302047-vv5gpldi	419	27	,	,	,
cord-302047-vv5gpldi	419	28	and	and	CC
cord-302047-vv5gpldi	419	29	Davis	Davis	NNP
cord-302047-vv5gpldi	419	30	1974	1974	CD
cord-302047-vv5gpldi	419	31	;	;	:
cord-302047-vv5gpldi	419	32	Gladstone	Gladstone	NNP
cord-302047-vv5gpldi	419	33	,	,	,
cord-302047-vv5gpldi	419	34	Molineux	Molineux	NNP
cord-302047-vv5gpldi	419	35	,	,	,
cord-302047-vv5gpldi	419	36	and	and	CC
cord-302047-vv5gpldi	419	37	Bull	Bull	NNP
cord-302047-vv5gpldi	419	38	2012	2012	CD
cord-302047-vv5gpldi	419	39	;	;	:
cord-302047-vv5gpldi	419	40	Schmerer	Schmerer	NNP
cord-302047-vv5gpldi	419	41	et	et	NNP
cord-302047-vv5gpldi	419	42	al	al	NNP
cord-302047-vv5gpldi	419	43	.	.	.
cord-302047-vv5gpldi	420	1	2014	2014	CD
cord-302047-vv5gpldi	420	2	;	;	:
cord-302047-vv5gpldi	420	3	Willemsen	Willemsen	NNP
cord-302047-vv5gpldi	420	4	et	et	NNP
cord-302047-vv5gpldi	420	5	al	al	NNP
cord-302047-vv5gpldi	420	6	.	.	.
cord-302047-vv5gpldi	420	7	2017	2017	CD
cord-302047-vv5gpldi	420	8	)	)	-RRB-
cord-302047-vv5gpldi	420	9	.	.	.
cord-302047-vv5gpldi	421	1	Beneficial	beneficial	JJ
cord-302047-vv5gpldi	421	2	effects	effect	NNS
cord-302047-vv5gpldi	421	3	could	could	MD
cord-302047-vv5gpldi	421	4	promote	promote	VB
cord-302047-vv5gpldi	421	5	insertion	insertion	NN
cord-302047-vv5gpldi	421	6	stability	stability	NN
cord-302047-vv5gpldi	421	7	and	and	CC
cord-302047-vv5gpldi	421	8	are	be	VBP
cord-302047-vv5gpldi	421	9	therefore	therefore	RB
cord-302047-vv5gpldi	421	10	interesting	interesting	JJ
cord-302047-vv5gpldi	421	11	from	from	IN
cord-302047-vv5gpldi	421	12	a	a	DT
cord-302047-vv5gpldi	421	13	bioengineering	bioengineering	NN
cord-302047-vv5gpldi	421	14	perspective	perspective	NN
cord-302047-vv5gpldi	421	15	,	,	,
cord-302047-vv5gpldi	421	16	but	but	CC
cord-302047-vv5gpldi	421	17	demography	demography	NN
cord-302047-vv5gpldi	421	18	can	can	MD
cord-302047-vv5gpldi	421	19	once	once	RB
cord-302047-vv5gpldi	421	20	again	again	RB
cord-302047-vv5gpldi	421	21	play	play	VB
cord-302047-vv5gpldi	421	22	a	a	DT
cord-302047-vv5gpldi	421	23	role	role	NN
cord-302047-vv5gpldi	421	24	in	in	IN
cord-302047-vv5gpldi	421	25	determining	determine	VBG
cord-302047-vv5gpldi	421	26	sequence	sequence	NN
cord-302047-vv5gpldi	421	27	stability	stability	NN
cord-302047-vv5gpldi	421	28	.	.	.
cord-302047-vv5gpldi	422	1	Heterologous	heterologous	JJ
cord-302047-vv5gpldi	422	2	expression	expression	NN
cord-302047-vv5gpldi	422	3	of	of	IN
cord-302047-vv5gpldi	422	4	endosialidase	endosialidase	NN
cord-302047-vv5gpldi	422	5	,	,	,
cord-302047-vv5gpldi	422	6	an	an	DT
cord-302047-vv5gpldi	422	7	exoenzyme	exoenzyme	NNS
cord-302047-vv5gpldi	422	8	that	that	WDT
cord-302047-vv5gpldi	422	9	degrades	degrade	VBZ
cord-302047-vv5gpldi	422	10	a	a	DT
cord-302047-vv5gpldi	422	11	key	key	JJ
cord-302047-vv5gpldi	422	12	biofilm	biofilm	NN
cord-302047-vv5gpldi	422	13	component	component	NN
cord-302047-vv5gpldi	422	14	after	after	IN
cord-302047-vv5gpldi	422	15	phageinduced	phageinduced	JJ
cord-302047-vv5gpldi	422	16	cell	cell	NN
cord-302047-vv5gpldi	422	17	lysis	lysis	NN
cord-302047-vv5gpldi	422	18	,	,	,
cord-302047-vv5gpldi	422	19	lead	lead	VB
cord-302047-vv5gpldi	422	20	to	to	IN
cord-302047-vv5gpldi	422	21	increased	increase	VBN
cord-302047-vv5gpldi	422	22	amplification	amplification	NN
cord-302047-vv5gpldi	422	23	of	of	IN
cord-302047-vv5gpldi	422	24	phage	phage	NN
cord-302047-vv5gpldi	422	25	T7	t7	NN
cord-302047-vv5gpldi	422	26	in	in	IN
cord-302047-vv5gpldi	422	27	capsulated	capsulated	JJ
cord-302047-vv5gpldi	422	28	E.coli	E.coli	NNS
cord-302047-vv5gpldi	422	29	(	(	-LRB-
cord-302047-vv5gpldi	422	30	Gladstone	Gladstone	NNP
cord-302047-vv5gpldi	422	31	,	,	,
cord-302047-vv5gpldi	422	32	Molineux	Molineux	NNP
cord-302047-vv5gpldi	422	33	,	,	,
cord-302047-vv5gpldi	422	34	and	and	CC
cord-302047-vv5gpldi	422	35	Bull	Bull	NNP
cord-302047-vv5gpldi	422	36	2012	2012	CD
cord-302047-vv5gpldi	422	37	)	)	-RRB-
cord-302047-vv5gpldi	422	38	.	.	.
cord-302047-vv5gpldi	423	1	However	however	RB
cord-302047-vv5gpldi	423	2	,	,	,
cord-302047-vv5gpldi	423	3	a	a	DT
cord-302047-vv5gpldi	423	4	phage	phage	NN
cord-302047-vv5gpldi	423	5	that	that	WDT
cord-302047-vv5gpldi	423	6	did	do	VBD
cord-302047-vv5gpldi	423	7	not	not	RB
cord-302047-vv5gpldi	423	8	express	express	VB
cord-302047-vv5gpldi	423	9	the	the	DT
cord-302047-vv5gpldi	423	10	dispersin	dispersin	NNP
cord-302047-vv5gpldi	423	11	outcompeted	outcompete	VBD
cord-302047-vv5gpldi	423	12	the	the	DT
cord-302047-vv5gpldi	423	13	engineered	engineer	VBN
cord-302047-vv5gpldi	423	14	virus	virus	NN
cord-302047-vv5gpldi	423	15	,	,	,
cord-302047-vv5gpldi	423	16	as	as	IN
cord-302047-vv5gpldi	423	17	it	-PRON-	PRP
cord-302047-vv5gpldi	423	18	could	could	MD
cord-302047-vv5gpldi	423	19	reap	reap	VB
cord-302047-vv5gpldi	423	20	the	the	DT
cord-302047-vv5gpldi	423	21	benefits	benefit	NNS
cord-302047-vv5gpldi	423	22	of	of	IN
cord-302047-vv5gpldi	423	23	dispersin	dispersin	NNP
cord-302047-vv5gpldi	423	24	production	production	NN
cord-302047-vv5gpldi	423	25	whilst	whilst	IN
cord-302047-vv5gpldi	423	26	not	not	RB
cord-302047-vv5gpldi	423	27	bearing	bear	VBG
cord-302047-vv5gpldi	423	28	costs	cost	NNS
cord-302047-vv5gpldi	423	29	.	.	.
cord-302047-vv5gpldi	424	1	This	this	DT
cord-302047-vv5gpldi	424	2	tragedy	tragedy	NN
cord-302047-vv5gpldi	424	3	of	of	IN
cord-302047-vv5gpldi	424	4	the	the	DT
cord-302047-vv5gpldi	424	5	commons	common	NNS
cord-302047-vv5gpldi	424	6	is	be	VBZ
cord-302047-vv5gpldi	424	7	a	a	DT
cord-302047-vv5gpldi	424	8	reversal	reversal	NN
cord-302047-vv5gpldi	424	9	of	of	IN
cord-302047-vv5gpldi	424	10	the	the	DT
cord-302047-vv5gpldi	424	11	situation	situation	NN
cord-302047-vv5gpldi	424	12	sketched	sketch	VBN
cord-302047-vv5gpldi	424	13	above	above	RB
cord-302047-vv5gpldi	424	14	for	for	IN
cord-302047-vv5gpldi	424	15	high	high	JJ
cord-302047-vv5gpldi	424	16	MOIs	moi	NNS
cord-302047-vv5gpldi	424	17	(	(	-LRB-
cord-302047-vv5gpldi	424	18	Fig	fig	NN
cord-302047-vv5gpldi	424	19	.	.	.
cord-302047-vv5gpldi	424	20	3	3	CD
cord-302047-vv5gpldi	424	21	)	)	-RRB-
cord-302047-vv5gpldi	424	22	.	.	.
cord-302047-vv5gpldi	425	1	One	one	CD
cord-302047-vv5gpldi	425	2	proposed	propose	VBN
cord-302047-vv5gpldi	425	3	strategy	strategy	NN
cord-302047-vv5gpldi	425	4	to	to	TO
cord-302047-vv5gpldi	425	5	increase	increase	VB
cord-302047-vv5gpldi	425	6	stability	stability	NN
cord-302047-vv5gpldi	425	7	would	would	MD
cord-302047-vv5gpldi	425	8	be	be	VB
cord-302047-vv5gpldi	425	9	setting	set	VBG
cord-302047-vv5gpldi	425	10	up	up	RP
cord-302047-vv5gpldi	425	11	culture	culture	NN
cord-302047-vv5gpldi	425	12	conditions	condition	NNS
cord-302047-vv5gpldi	425	13	such	such	JJ
cord-302047-vv5gpldi	425	14	that	that	IN
cord-302047-vv5gpldi	425	15	phages	phage	NNS
cord-302047-vv5gpldi	425	16	are	be	VBP
cord-302047-vv5gpldi	425	17	growing	grow	VBG
cord-302047-vv5gpldi	425	18	in	in	IN
cord-302047-vv5gpldi	425	19	isolation	isolation	NN
cord-302047-vv5gpldi	425	20	or	or	CC
cord-302047-vv5gpldi	425	21	spatially	spatially	RB
cord-302047-vv5gpldi	425	22	structured	structured	JJ
cord-302047-vv5gpldi	425	23	environments	environment	NNS
cord-302047-vv5gpldi	425	24	(	(	-LRB-
cord-302047-vv5gpldi	425	25	Gladstone	Gladstone	NNP
cord-302047-vv5gpldi	425	26	,	,	,
cord-302047-vv5gpldi	425	27	Molineux	Molineux	NNP
cord-302047-vv5gpldi	425	28	,	,	,
cord-302047-vv5gpldi	425	29	and	and	CC
cord-302047-vv5gpldi	425	30	Bull	Bull	NNP
cord-302047-vv5gpldi	425	31	2012	2012	CD
cord-302047-vv5gpldi	425	32	)	)	-RRB-
cord-302047-vv5gpldi	425	33	,	,	,
cord-302047-vv5gpldi	425	34	other	other	JJ
cord-302047-vv5gpldi	425	35	examples	example	NNS
cord-302047-vv5gpldi	425	36	of	of	IN
cord-302047-vv5gpldi	425	37	demography	demography	NN
cord-302047-vv5gpldi	425	38	-	-	HYPH
cord-302047-vv5gpldi	425	39	based	base	VBN
cord-302047-vv5gpldi	425	40	approaches	approach	NNS
cord-302047-vv5gpldi	425	41	to	to	IN
cord-302047-vv5gpldi	425	42	increasing	increase	VBG
cord-302047-vv5gpldi	425	43	insert	insert	JJ
cord-302047-vv5gpldi	425	44	stability	stability	NN
cord-302047-vv5gpldi	425	45	.	.	.
cord-302047-vv5gpldi	426	1	It	-PRON-	PRP
cord-302047-vv5gpldi	426	2	will	will	MD
cord-302047-vv5gpldi	426	3	certainly	certainly	RB
cord-302047-vv5gpldi	426	4	not	not	RB
cord-302047-vv5gpldi	426	5	always	always	RB
cord-302047-vv5gpldi	426	6	be	be	VB
cord-302047-vv5gpldi	426	7	possible	possible	JJ
cord-302047-vv5gpldi	426	8	to	to	TO
cord-302047-vv5gpldi	426	9	address	address	VB
cord-302047-vv5gpldi	426	10	issues	issue	NNS
cord-302047-vv5gpldi	426	11	of	of	IN
cord-302047-vv5gpldi	426	12	insert	insert	VB
cord-302047-vv5gpldi	426	13	stability	stability	NN
cord-302047-vv5gpldi	426	14	through	through	IN
cord-302047-vv5gpldi	426	15	demographic	demographic	JJ
cord-302047-vv5gpldi	426	16	changes	change	NNS
cord-302047-vv5gpldi	426	17	,	,	,
cord-302047-vv5gpldi	426	18	but	but	CC
cord-302047-vv5gpldi	426	19	theory	theory	NN
cord-302047-vv5gpldi	426	20	suggests	suggest	VBZ
cord-302047-vv5gpldi	426	21	this	this	DT
cord-302047-vv5gpldi	426	22	can	can	MD
cord-302047-vv5gpldi	426	23	be	be	VB
cord-302047-vv5gpldi	426	24	an	an	DT
cord-302047-vv5gpldi	426	25	interesting	interesting	JJ
cord-302047-vv5gpldi	426	26	approach	approach	NN
cord-302047-vv5gpldi	426	27	.	.	.
cord-302047-vv5gpldi	427	1	Some	some	DT
cord-302047-vv5gpldi	427	2	experimental	experimental	JJ
cord-302047-vv5gpldi	427	3	protocols	protocol	NNS
cord-302047-vv5gpldi	427	4	already	already	RB
cord-302047-vv5gpldi	427	5	exploit	exploit	VBP
cord-302047-vv5gpldi	427	6	some	some	DT
cord-302047-vv5gpldi	427	7	of	of	IN
cord-302047-vv5gpldi	427	8	these	these	DT
cord-302047-vv5gpldi	427	9	principles	principle	NNS
cord-302047-vv5gpldi	427	10	,	,	,
cord-302047-vv5gpldi	427	11	in	in	IN
cord-302047-vv5gpldi	427	12	particular	particular	JJ
cord-302047-vv5gpldi	427	13	strict	strict	JJ
cord-302047-vv5gpldi	427	14	adherence	adherence	NN
cord-302047-vv5gpldi	427	15	to	to	IN
cord-302047-vv5gpldi	427	16	low	low	JJ
cord-302047-vv5gpldi	427	17	MOI	MOI	NNP
cord-302047-vv5gpldi	427	18	(	(	-LRB-
cord-302047-vv5gpldi	427	19	Fitzgerald	Fitzgerald	NNP
cord-302047-vv5gpldi	427	20	et	et	NNP
cord-302047-vv5gpldi	427	21	al	al	NNP
cord-302047-vv5gpldi	427	22	.	.	.
cord-302047-vv5gpldi	427	23	2006	2006	CD
cord-302047-vv5gpldi	427	24	)	)	-RRB-
cord-302047-vv5gpldi	427	25	.	.	.
cord-302047-vv5gpldi	428	1	One	one	PRP
cord-302047-vv5gpldi	428	2	should	should	MD
cord-302047-vv5gpldi	428	3	caution	caution	VB
cord-302047-vv5gpldi	428	4	against	against	IN
cord-302047-vv5gpldi	428	5	naive	naive	JJ
cord-302047-vv5gpldi	428	6	applications	application	NNS
cord-302047-vv5gpldi	428	7	of	of	IN
cord-302047-vv5gpldi	428	8	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	428	9	theory	theory	NN
cord-302047-vv5gpldi	428	10	,	,	,
cord-302047-vv5gpldi	428	11	as	as	IN
cord-302047-vv5gpldi	428	12	the	the	DT
cord-302047-vv5gpldi	428	13	details	detail	NNS
cord-302047-vv5gpldi	428	14	of	of	IN
cord-302047-vv5gpldi	428	15	each	each	DT
cord-302047-vv5gpldi	428	16	real	real	JJ
cord-302047-vv5gpldi	428	17	-	-	HYPH
cord-302047-vv5gpldi	428	18	world	world	NN
cord-302047-vv5gpldi	428	19	system	system	NN
cord-302047-vv5gpldi	428	20	matter	matter	NN
cord-302047-vv5gpldi	428	21	(	(	-LRB-
cord-302047-vv5gpldi	428	22	Schmerer	Schmerer	NNP
cord-302047-vv5gpldi	428	23	et	et	NNP
cord-302047-vv5gpldi	428	24	al	al	NNP
cord-302047-vv5gpldi	428	25	.	.	NNP
cord-302047-vv5gpldi	428	26	2014	2014	CD
cord-302047-vv5gpldi	428	27	)	)	-RRB-
cord-302047-vv5gpldi	428	28	.	.	.
cord-302047-vv5gpldi	429	1	There	there	EX
cord-302047-vv5gpldi	429	2	are	be	VBP
cord-302047-vv5gpldi	429	3	multiple	multiple	JJ
cord-302047-vv5gpldi	429	4	,	,	,
cord-302047-vv5gpldi	429	5	non	non	JJ
cord-302047-vv5gpldi	429	6	-	-	JJ
cord-302047-vv5gpldi	429	7	mutually	mutually	RB
cord-302047-vv5gpldi	429	8	exclusive	exclusive	JJ
cord-302047-vv5gpldi	429	9	mechanisms	mechanism	NNS
cord-302047-vv5gpldi	429	10	by	by	IN
cord-302047-vv5gpldi	429	11	which	which	WDT
cord-302047-vv5gpldi	429	12	an	an	DT
cord-302047-vv5gpldi	429	13	inserted	insert	VBN
cord-302047-vv5gpldi	429	14	sequence	sequence	NN
cord-302047-vv5gpldi	429	15	can	can	MD
cord-302047-vv5gpldi	429	16	be	be	VB
cord-302047-vv5gpldi	429	17	costly	costly	JJ
cord-302047-vv5gpldi	429	18	for	for	IN
cord-302047-vv5gpldi	429	19	a	a	DT
cord-302047-vv5gpldi	429	20	virus	virus	NN
cord-302047-vv5gpldi	429	21	.	.	.
cord-302047-vv5gpldi	430	1	Consequently	consequently	RB
cord-302047-vv5gpldi	430	2	,	,	,
cord-302047-vv5gpldi	430	3	deletion	deletion	NN
cord-302047-vv5gpldi	430	4	of	of	IN
cord-302047-vv5gpldi	430	5	the	the	DT
cord-302047-vv5gpldi	430	6	inserted	insert	VBN
cord-302047-vv5gpldi	430	7	sequence	sequence	NN
cord-302047-vv5gpldi	430	8	may	may	MD
cord-302047-vv5gpldi	430	9	not	not	RB
cord-302047-vv5gpldi	430	10	be	be	VB
cord-302047-vv5gpldi	430	11	the	the	DT
cord-302047-vv5gpldi	430	12	only	only	JJ
cord-302047-vv5gpldi	430	13	class	class	NN
cord-302047-vv5gpldi	430	14	of	of	IN
cord-302047-vv5gpldi	430	15	mutation	mutation	NN
cord-302047-vv5gpldi	430	16	that	that	WDT
cord-302047-vv5gpldi	430	17	ameliorates	ameliorate	VBZ
cord-302047-vv5gpldi	430	18	the	the	DT
cord-302047-vv5gpldi	430	19	insert	insert	NN
cord-302047-vv5gpldi	430	20	's	's	POS
cord-302047-vv5gpldi	430	21	effects	effect	NNS
cord-302047-vv5gpldi	430	22	on	on	IN
cord-302047-vv5gpldi	430	23	fitness	fitness	NN
cord-302047-vv5gpldi	430	24	,	,	,
cord-302047-vv5gpldi	430	25	a	a	DT
cord-302047-vv5gpldi	430	26	possibility	possibility	NN
cord-302047-vv5gpldi	430	27	we	-PRON-	PRP
cord-302047-vv5gpldi	430	28	explore	explore	VBP
cord-302047-vv5gpldi	430	29	in	in	IN
cord-302047-vv5gpldi	430	30	this	this	DT
cord-302047-vv5gpldi	430	31	section	section	NN
cord-302047-vv5gpldi	430	32	.	.	.
cord-302047-vv5gpldi	431	1	We	-PRON-	PRP
cord-302047-vv5gpldi	431	2	argue	argue	VBP
cord-302047-vv5gpldi	431	3	that	that	IN
cord-302047-vv5gpldi	431	4	alternative	alternative	JJ
cord-302047-vv5gpldi	431	5	trajectories	trajectory	NNS
cord-302047-vv5gpldi	431	6	may	may	MD
cord-302047-vv5gpldi	431	7	sometimes	sometimes	RB
cord-302047-vv5gpldi	431	8	play	play	VB
cord-302047-vv5gpldi	431	9	a	a	DT
cord-302047-vv5gpldi	431	10	role	role	NN
cord-302047-vv5gpldi	431	11	,	,	,
cord-302047-vv5gpldi	431	12	but	but	CC
cord-302047-vv5gpldi	431	13	that	that	IN
cord-302047-vv5gpldi	431	14	due	due	IN
cord-302047-vv5gpldi	431	15	to	to	IN
cord-302047-vv5gpldi	431	16	mutation	mutation	NN
cord-302047-vv5gpldi	431	17	supply	supply	NN
cord-302047-vv5gpldi	431	18	of	of	IN
cord-302047-vv5gpldi	431	19	different	different	JJ
cord-302047-vv5gpldi	431	20	types	type	NNS
cord-302047-vv5gpldi	431	21	of	of	IN
cord-302047-vv5gpldi	431	22	mutations	mutation	NNS
cord-302047-vv5gpldi	431	23	,	,	,
cord-302047-vv5gpldi	431	24	deletion	deletion	NN
cord-302047-vv5gpldi	431	25	of	of	IN
cord-302047-vv5gpldi	431	26	the	the	DT
cord-302047-vv5gpldi	431	27	inserted	insert	VBN
cord-302047-vv5gpldi	431	28	sequence	sequence	NN
cord-302047-vv5gpldi	431	29	is	be	VBZ
cord-302047-vv5gpldi	431	30	the	the	DT
cord-302047-vv5gpldi	431	31	most	most	RBS
cord-302047-vv5gpldi	431	32	likely	likely	JJ
cord-302047-vv5gpldi	431	33	trajectory	trajectory	NN
cord-302047-vv5gpldi	431	34	.	.	.
cord-302047-vv5gpldi	432	1	A	a	DT
cord-302047-vv5gpldi	432	2	cost	cost	NN
cord-302047-vv5gpldi	432	3	of	of	IN
cord-302047-vv5gpldi	432	4	the	the	DT
cord-302047-vv5gpldi	432	5	insert	insert	NN
cord-302047-vv5gpldi	432	6	can	can	MD
cord-302047-vv5gpldi	432	7	arise	arise	VB
cord-302047-vv5gpldi	432	8	because	because	IN
cord-302047-vv5gpldi	432	9	of	of	IN
cord-302047-vv5gpldi	432	10	the	the	DT
cord-302047-vv5gpldi	432	11	attributes	attribute	NNS
cord-302047-vv5gpldi	432	12	of	of	IN
cord-302047-vv5gpldi	432	13	the	the	DT
cord-302047-vv5gpldi	432	14	inserted	insert	VBN
cord-302047-vv5gpldi	432	15	sequence	sequence	NN
cord-302047-vv5gpldi	432	16	(	(	-LRB-
cord-302047-vv5gpldi	432	17	i.e.	i.e.	FW
cord-302047-vv5gpldi	432	18	metabolic	metabolic	JJ
cord-302047-vv5gpldi	432	19	costs	cost	NNS
cord-302047-vv5gpldi	432	20	of	of	IN
cord-302047-vv5gpldi	432	21	expressing	express	VBG
cord-302047-vv5gpldi	432	22	extra	extra	JJ
cord-302047-vv5gpldi	432	23	genes	gene	NNS
cord-302047-vv5gpldi	432	24	,	,	,
cord-302047-vv5gpldi	432	25	toxicity	toxicity	NN
cord-302047-vv5gpldi	432	26	of	of	IN
cord-302047-vv5gpldi	432	27	gene	gene	NN
cord-302047-vv5gpldi	432	28	products	product	NNS
cord-302047-vv5gpldi	432	29	)	)	-RRB-
cord-302047-vv5gpldi	432	30	,	,	,
cord-302047-vv5gpldi	432	31	reorganization	reorganization	NN
cord-302047-vv5gpldi	432	32	of	of	IN
cord-302047-vv5gpldi	432	33	the	the	DT
cord-302047-vv5gpldi	432	34	genome	genome	NN
cord-302047-vv5gpldi	432	35	due	due	IN
cord-302047-vv5gpldi	432	36	to	to	IN
cord-302047-vv5gpldi	432	37	the	the	DT
cord-302047-vv5gpldi	432	38	insertion	insertion	NN
cord-302047-vv5gpldi	432	39	(	(	-LRB-
cord-302047-vv5gpldi	432	40	i.e.	i.e.	FW
cord-302047-vv5gpldi	432	41	disruption	disruption	NN
cord-302047-vv5gpldi	432	42	of	of	IN
cord-302047-vv5gpldi	432	43	the	the	DT
cord-302047-vv5gpldi	432	44	regulation	regulation	NN
cord-302047-vv5gpldi	432	45	of	of	IN
cord-302047-vv5gpldi	432	46	gene	gene	NN
cord-302047-vv5gpldi	432	47	expression	expression	NN
cord-302047-vv5gpldi	432	48	,	,	,
cord-302047-vv5gpldi	432	49	polyprotein	polyprotein	NN
cord-302047-vv5gpldi	432	50	processing	processing	NN
cord-302047-vv5gpldi	432	51	,	,	,
cord-302047-vv5gpldi	432	52	and	and	CC
cord-302047-vv5gpldi	432	53	subgenomic	subgenomic	NNP
cord-302047-vv5gpldi	432	54	RNAs	RNAs	NNPS
cord-302047-vv5gpldi	432	55	)	)	-RRB-
cord-302047-vv5gpldi	432	56	,	,	,
cord-302047-vv5gpldi	432	57	or	or	CC
cord-302047-vv5gpldi	432	58	limitations	limitation	NNS
cord-302047-vv5gpldi	432	59	on	on	IN
cord-302047-vv5gpldi	432	60	genome	genome	NN
cord-302047-vv5gpldi	432	61	size	size	NN
cord-302047-vv5gpldi	432	62	imposed	impose	VBN
cord-302047-vv5gpldi	432	63	by	by	IN
cord-302047-vv5gpldi	432	64	virus	virus	NN
cord-302047-vv5gpldi	432	65	-	-	HYPH
cord-302047-vv5gpldi	432	66	particle	particle	NN
cord-302047-vv5gpldi	432	67	packaging	packaging	NN
cord-302047-vv5gpldi	432	68	.	.	.
cord-302047-vv5gpldi	433	1	Deletion	deletion	NN
cord-302047-vv5gpldi	433	2	of	of	IN
cord-302047-vv5gpldi	433	3	the	the	DT
cord-302047-vv5gpldi	433	4	inserted	insert	VBN
cord-302047-vv5gpldi	433	5	sequence	sequence	NN
cord-302047-vv5gpldi	433	6	is	be	VBZ
cord-302047-vv5gpldi	433	7	therefore	therefore	RB
cord-302047-vv5gpldi	433	8	not	not	RB
cord-302047-vv5gpldi	433	9	the	the	DT
cord-302047-vv5gpldi	433	10	only	only	JJ
cord-302047-vv5gpldi	433	11	plausible	plausible	JJ
cord-302047-vv5gpldi	433	12	class	class	NN
cord-302047-vv5gpldi	433	13	of	of	IN
cord-302047-vv5gpldi	433	14	mutation	mutation	NN
cord-302047-vv5gpldi	433	15	that	that	WDT
cord-302047-vv5gpldi	433	16	can	can	MD
cord-302047-vv5gpldi	433	17	restore	restore	VB
cord-302047-vv5gpldi	433	18	viral	viral	JJ
cord-302047-vv5gpldi	433	19	fitness	fitness	NN
cord-302047-vv5gpldi	433	20	,	,	,
cord-302047-vv5gpldi	433	21	as	as	IN
cord-302047-vv5gpldi	433	22	other	other	JJ
cord-302047-vv5gpldi	433	23	mutations	mutation	NNS
cord-302047-vv5gpldi	433	24	can	can	MD
cord-302047-vv5gpldi	433	25	also	also	RB
cord-302047-vv5gpldi	433	26	affect	affect	VB
cord-302047-vv5gpldi	433	27	fitness	fitness	NN
cord-302047-vv5gpldi	433	28	.	.	.
cord-302047-vv5gpldi	434	1	These	these	DT
cord-302047-vv5gpldi	434	2	mutation	mutation	NN
cord-302047-vv5gpldi	434	3	types	type	NNS
cord-302047-vv5gpldi	434	4	are	be	VBP
cord-302047-vv5gpldi	434	5	1	1	CD
cord-302047-vv5gpldi	434	6	,	,	,
cord-302047-vv5gpldi	434	7	regulatory	regulatory	JJ
cord-302047-vv5gpldi	434	8	mutations	mutation	NNS
cord-302047-vv5gpldi	434	9	(	(	-LRB-
cord-302047-vv5gpldi	434	10	i.e.	i.e.	FW
cord-302047-vv5gpldi	434	11	promoter	promoter	NN
cord-302047-vv5gpldi	434	12	mutations	mutation	NNS
cord-302047-vv5gpldi	434	13	)	)	-RRB-
cord-302047-vv5gpldi	434	14	that	that	WDT
cord-302047-vv5gpldi	434	15	downregulate	downregulate	VBP
cord-302047-vv5gpldi	434	16	gene	gene	NN
cord-302047-vv5gpldi	434	17	expression	expression	NN
cord-302047-vv5gpldi	434	18	(	(	-LRB-
cord-302047-vv5gpldi	434	19	van	van	NNP
cord-302047-vv5gpldi	434	20	Opijnen	Opijnen	NNP
cord-302047-vv5gpldi	434	21	,	,	,
cord-302047-vv5gpldi	434	22	Boerlijst	Boerlijst	NNP
cord-302047-vv5gpldi	434	23	,	,	,
cord-302047-vv5gpldi	434	24	and	and	CC
cord-302047-vv5gpldi	434	25	Berkhout	Berkhout	NNP
cord-302047-vv5gpldi	434	26	2006	2006	CD
cord-302047-vv5gpldi	434	27	)	)	-RRB-
cord-302047-vv5gpldi	434	28	,	,	,
cord-302047-vv5gpldi	434	29	2	2	CD
cord-302047-vv5gpldi	434	30	,	,	,
cord-302047-vv5gpldi	434	31	removal	removal	NN
cord-302047-vv5gpldi	434	32	of	of	IN
cord-302047-vv5gpldi	434	33	immunogenic	immunogenic	JJ
cord-302047-vv5gpldi	434	34	sequence	sequence	NN
cord-302047-vv5gpldi	434	35	motifs	motif	NNS
cord-302047-vv5gpldi	434	36	(	(	-LRB-
cord-302047-vv5gpldi	434	37	Fros	Fros	NNP
cord-302047-vv5gpldi	434	38	et	et	FW
cord-302047-vv5gpldi	434	39	al	al	NNP
cord-302047-vv5gpldi	434	40	.	.	.
cord-302047-vv5gpldi	434	41	2017	2017	CD
cord-302047-vv5gpldi	434	42	)	)	-RRB-
cord-302047-vv5gpldi	434	43	,	,	,
cord-302047-vv5gpldi	434	44	3	3	CD
cord-302047-vv5gpldi	434	45	,	,	,
cord-302047-vv5gpldi	434	46	alteration	alteration	NN
cord-302047-vv5gpldi	434	47	of	of	IN
cord-302047-vv5gpldi	434	48	unfavorable	unfavorable	JJ
cord-302047-vv5gpldi	434	49	secondary	secondary	JJ
cord-302047-vv5gpldi	434	50	RNA	RNA	NNP
cord-302047-vv5gpldi	434	51	structures	structure	NNS
cord-302047-vv5gpldi	434	52	(	(	-LRB-
cord-302047-vv5gpldi	434	53	McFadden	McFadden	NNP
cord-302047-vv5gpldi	434	54	et	et	NNP
cord-302047-vv5gpldi	434	55	al	al	NNP
cord-302047-vv5gpldi	434	56	.	.	NNP
cord-302047-vv5gpldi	434	57	2013	2013	CD
cord-302047-vv5gpldi	434	58	)	)	-RRB-
cord-302047-vv5gpldi	434	59	,	,	,
cord-302047-vv5gpldi	434	60	and	and	CC
cord-302047-vv5gpldi	434	61	4	4	CD
cord-302047-vv5gpldi	434	62	,	,	,
cord-302047-vv5gpldi	434	63	adopting	adopt	VBG
cord-302047-vv5gpldi	434	64	a	a	DT
cord-302047-vv5gpldi	434	65	more	more	RBR
cord-302047-vv5gpldi	434	66	favorable	favorable	JJ
cord-302047-vv5gpldi	434	67	codon	codon	NN
cord-302047-vv5gpldi	434	68	usage	usage	NN
cord-302047-vv5gpldi	434	69	(	(	-LRB-
cord-302047-vv5gpldi	434	70	Carrasco	Carrasco	NNP
cord-302047-vv5gpldi	434	71	,	,	,
cord-302047-vv5gpldi	434	72	de	de	FW
cord-302047-vv5gpldi	434	73	la	la	FW
cord-302047-vv5gpldi	434	74	Iglesia	Iglesia	NNP
cord-302047-vv5gpldi	434	75	,	,	,
cord-302047-vv5gpldi	434	76	and	and	CC
cord-302047-vv5gpldi	434	77	Elena	Elena	NNP
cord-302047-vv5gpldi	434	78	2007	2007	CD
cord-302047-vv5gpldi	434	79	;	;	:
cord-302047-vv5gpldi	435	1	Agashe	Agashe	NNP
cord-302047-vv5gpldi	435	2	et	et	NNP
cord-302047-vv5gpldi	435	3	al	al	NNP
cord-302047-vv5gpldi	435	4	.	.	.
cord-302047-vv5gpldi	436	1	2013	2013	CD
cord-302047-vv5gpldi	436	2	;	;	:
cord-302047-vv5gpldi	436	3	Cladel	Cladel	NNP
cord-302047-vv5gpldi	436	4	et	et	NNP
cord-302047-vv5gpldi	436	5	al	al	NNP
cord-302047-vv5gpldi	436	6	.	.	NNP
cord-302047-vv5gpldi	436	7	2013	2013	CD
cord-302047-vv5gpldi	436	8	)	)	-RRB-
cord-302047-vv5gpldi	436	9	,	,	,
cord-302047-vv5gpldi	436	10	as	as	IN
cord-302047-vv5gpldi	436	11	synonymous	synonymous	JJ
cord-302047-vv5gpldi	436	12	mutations	mutation	NNS
cord-302047-vv5gpldi	436	13	can	can	MD
cord-302047-vv5gpldi	436	14	have	have	VB
cord-302047-vv5gpldi	436	15	marked	mark	VBN
cord-302047-vv5gpldi	436	16	effects	effect	NNS
cord-302047-vv5gpldi	436	17	on	on	IN
cord-302047-vv5gpldi	436	18	virus	virus	NN
cord-302047-vv5gpldi	436	19	fitness	fitness	NN
cord-302047-vv5gpldi	436	20	.	.	.
cord-302047-vv5gpldi	437	1	These	these	DT
cord-302047-vv5gpldi	437	2	different	different	JJ
cord-302047-vv5gpldi	437	3	mutation	mutation	NN
cord-302047-vv5gpldi	437	4	classes	class	NNS
cord-302047-vv5gpldi	437	5	are	be	VBP
cord-302047-vv5gpldi	437	6	likely	likely	JJ
cord-302047-vv5gpldi	437	7	to	to	TO
cord-302047-vv5gpldi	437	8	have	have	VB
cord-302047-vv5gpldi	437	9	different	different	JJ
cord-302047-vv5gpldi	437	10	mutation	mutation	NN
cord-302047-vv5gpldi	437	11	rates	rate	NNS
cord-302047-vv5gpldi	437	12	,	,	,
cord-302047-vv5gpldi	437	13	and	and	CC
cord-302047-vv5gpldi	437	14	mutation	mutation	NN
cord-302047-vv5gpldi	437	15	bias	bias	NN
cord-302047-vv5gpldi	437	16	might	may	MD
cord-302047-vv5gpldi	437	17	therefore	therefore	RB
cord-302047-vv5gpldi	437	18	drive	drive	VB
cord-302047-vv5gpldi	437	19	the	the	DT
cord-302047-vv5gpldi	437	20	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	437	21	route	route	NN
cord-302047-vv5gpldi	437	22	that	that	WDT
cord-302047-vv5gpldi	437	23	is	be	VBZ
cord-302047-vv5gpldi	437	24	followed	follow	VBN
cord-302047-vv5gpldi	437	25	(	(	-LRB-
cord-302047-vv5gpldi	437	26	Stoltzfus	Stoltzfus	NNP
cord-302047-vv5gpldi	437	27	and	and	CC
cord-302047-vv5gpldi	437	28	McCandlish	McCandlish	NNP
cord-302047-vv5gpldi	437	29	2017	2017	CD
cord-302047-vv5gpldi	437	30	)	)	-RRB-
cord-302047-vv5gpldi	437	31	.	.	.
cord-302047-vv5gpldi	438	1	For	for	IN
cord-302047-vv5gpldi	438	2	example	example	NN
cord-302047-vv5gpldi	438	3	,	,	,
cord-302047-vv5gpldi	438	4	consider	consider	VB
cord-302047-vv5gpldi	438	5	that	that	IN
cord-302047-vv5gpldi	438	6	recombination	recombination	NN
cord-302047-vv5gpldi	438	7	rates	rate	NNS
cord-302047-vv5gpldi	438	8	are	be	VBP
cord-302047-vv5gpldi	438	9	high	high	JJ
cord-302047-vv5gpldi	438	10	for	for	IN
cord-302047-vv5gpldi	438	11	many	many	JJ
cord-302047-vv5gpldi	438	12	viruses	virus	NNS
cord-302047-vv5gpldi	438	13	(	(	-LRB-
cord-302047-vv5gpldi	438	14	Tromas	Tromas	NNP
cord-302047-vv5gpldi	438	15	and	and	CC
cord-302047-vv5gpldi	438	16	Elena	Elena	NNP
cord-302047-vv5gpldi	438	17	2010	2010	CD
cord-302047-vv5gpldi	438	18	)	)	-RRB-
cord-302047-vv5gpldi	438	19	,	,	,
cord-302047-vv5gpldi	438	20	and	and	CC
cord-302047-vv5gpldi	438	21	there	there	EX
cord-302047-vv5gpldi	438	22	are	be	VBP
cord-302047-vv5gpldi	438	23	many	many	JJ
cord-302047-vv5gpldi	438	24	Figure	figure	NN
cord-302047-vv5gpldi	438	25	3	3	CD
cord-302047-vv5gpldi	438	26	.	.	.
cord-302047-vv5gpldi	439	1	In	in	IN
cord-302047-vv5gpldi	439	2	panel	panel	NN
cord-302047-vv5gpldi	439	3	A	A	NNP
cord-302047-vv5gpldi	439	4	,	,	,
cord-302047-vv5gpldi	439	5	we	-PRON-	PRP
cord-302047-vv5gpldi	439	6	illustrate	illustrate	VBP
cord-302047-vv5gpldi	439	7	how	how	WRB
cord-302047-vv5gpldi	439	8	the	the	DT
cord-302047-vv5gpldi	439	9	cellular	cellular	JJ
cord-302047-vv5gpldi	439	10	MOI	MOI	NNP
cord-302047-vv5gpldi	439	11	can	can	MD
cord-302047-vv5gpldi	439	12	have	have	VB
cord-302047-vv5gpldi	439	13	a	a	DT
cord-302047-vv5gpldi	439	14	direct	direct	JJ
cord-302047-vv5gpldi	439	15	effect	effect	NN
cord-302047-vv5gpldi	439	16	on	on	IN
cord-302047-vv5gpldi	439	17	selection	selection	NN
cord-302047-vv5gpldi	439	18	strength	strength	NN
cord-302047-vv5gpldi	439	19	.	.	.
cord-302047-vv5gpldi	440	1	Consider	consider	VB
cord-302047-vv5gpldi	440	2	a	a	DT
cord-302047-vv5gpldi	440	3	virus	virus	NN
cord-302047-vv5gpldi	440	4	that	that	WDT
cord-302047-vv5gpldi	440	5	expresses	express	VBZ
cord-302047-vv5gpldi	440	6	a	a	DT
cord-302047-vv5gpldi	440	7	product	product	NN
cord-302047-vv5gpldi	440	8	that	that	WDT
cord-302047-vv5gpldi	440	9	is	be	VBZ
cord-302047-vv5gpldi	440	10	toxic	toxic	JJ
cord-302047-vv5gpldi	440	11	and	and	CC
cord-302047-vv5gpldi	440	12	acts	act	VBZ
cord-302047-vv5gpldi	440	13	in	in	IN
cord-302047-vv5gpldi	440	14	trans	trans	NNP
cord-302047-vv5gpldi	440	15	within	within	IN
cord-302047-vv5gpldi	440	16	cells	cell	NNS
cord-302047-vv5gpldi	440	17	to	to	IN
cord-302047-vv5gpldi	440	18	lower	lower	VB
cord-302047-vv5gpldi	440	19	replication	replication	NN
cord-302047-vv5gpldi	440	20	levels	level	NNS
cord-302047-vv5gpldi	440	21	,	,	,
cord-302047-vv5gpldi	440	22	but	but	CC
cord-302047-vv5gpldi	440	23	deletions	deletion	NNS
cord-302047-vv5gpldi	440	24	can	can	MD
cord-302047-vv5gpldi	440	25	remove	remove	VB
cord-302047-vv5gpldi	440	26	the	the	DT
cord-302047-vv5gpldi	440	27	gene	gene	NN
cord-302047-vv5gpldi	440	28	coding	code	VBG
cord-302047-vv5gpldi	440	29	this	this	DT
cord-302047-vv5gpldi	440	30	gene	gene	NN
cord-302047-vv5gpldi	440	31	.	.	.
cord-302047-vv5gpldi	441	1	If	if	IN
cord-302047-vv5gpldi	441	2	there	there	EX
cord-302047-vv5gpldi	441	3	is	be	VBZ
cord-302047-vv5gpldi	441	4	a	a	DT
cord-302047-vv5gpldi	441	5	mixed	mixed	JJ
cord-302047-vv5gpldi	441	6	virus	virus	NN
cord-302047-vv5gpldi	441	7	population	population	NN
cord-302047-vv5gpldi	441	8	with	with	IN
cord-302047-vv5gpldi	441	9	variants	variant	NNS
cord-302047-vv5gpldi	441	10	with	with	IN
cord-302047-vv5gpldi	441	11	the	the	DT
cord-302047-vv5gpldi	441	12	insertion	insertion	NN
cord-302047-vv5gpldi	441	13	intact	intact	JJ
cord-302047-vv5gpldi	441	14	and	and	CC
cord-302047-vv5gpldi	441	15	deleted	delete	VBN
cord-302047-vv5gpldi	441	16	,	,	,
cord-302047-vv5gpldi	441	17	at	at	IN
cord-302047-vv5gpldi	441	18	high	high	JJ
cord-302047-vv5gpldi	441	19	MOI	MOI	NNP
cord-302047-vv5gpldi	441	20	all	all	DT
cord-302047-vv5gpldi	441	21	cells	cell	NNS
cord-302047-vv5gpldi	441	22	will	will	MD
cord-302047-vv5gpldi	441	23	be	be	VB
cord-302047-vv5gpldi	441	24	infected	infect	VBN
cord-302047-vv5gpldi	441	25	with	with	IN
cord-302047-vv5gpldi	441	26	both	both	DT
cord-302047-vv5gpldi	441	27	variants	variant	NNS
cord-302047-vv5gpldi	441	28	and	and	CC
cord-302047-vv5gpldi	441	29	the	the	DT
cord-302047-vv5gpldi	441	30	toxin	toxin	NN
cord-302047-vv5gpldi	441	31	will	will	MD
cord-302047-vv5gpldi	441	32	lower	lower	VB
cord-302047-vv5gpldi	441	33	replication	replication	NN
cord-302047-vv5gpldi	441	34	.	.	.
cord-302047-vv5gpldi	442	1	The	the	DT
cord-302047-vv5gpldi	442	2	ubiquitousness	ubiquitousness	NN
cord-302047-vv5gpldi	442	3	of	of	IN
cord-302047-vv5gpldi	442	4	the	the	DT
cord-302047-vv5gpldi	442	5	toxin	toxin	NN
cord-302047-vv5gpldi	442	6	will	will	MD
cord-302047-vv5gpldi	442	7	limit	limit	VB
cord-302047-vv5gpldi	442	8	selection	selection	NN
cord-302047-vv5gpldi	442	9	against	against	IN
cord-302047-vv5gpldi	442	10	the	the	DT
cord-302047-vv5gpldi	442	11	virus	virus	NN
cord-302047-vv5gpldi	442	12	variant	variant	NN
cord-302047-vv5gpldi	442	13	with	with	IN
cord-302047-vv5gpldi	442	14	the	the	DT
cord-302047-vv5gpldi	442	15	deletion	deletion	NN
cord-302047-vv5gpldi	442	16	.	.	.
cord-302047-vv5gpldi	443	1	When	when	WRB
cord-302047-vv5gpldi	443	2	MOI	MOI	NNP
cord-302047-vv5gpldi	443	3	is	be	VBZ
cord-302047-vv5gpldi	443	4	low	low	JJ
cord-302047-vv5gpldi	443	5	,	,	,
cord-302047-vv5gpldi	443	6	due	due	IN
cord-302047-vv5gpldi	443	7	to	to	IN
cord-302047-vv5gpldi	443	8	genetic	genetic	JJ
cord-302047-vv5gpldi	443	9	drift	drift	NN
cord-302047-vv5gpldi	443	10	at	at	IN
cord-302047-vv5gpldi	443	11	the	the	DT
cord-302047-vv5gpldi	443	12	cellular	cellular	NN
cord-302047-vv5gpldi	443	13	not	not	RB
cord-302047-vv5gpldi	443	14	all	all	DT
cord-302047-vv5gpldi	443	15	cells	cell	NNS
cord-302047-vv5gpldi	443	16	will	will	MD
cord-302047-vv5gpldi	443	17	contain	contain	VB
cord-302047-vv5gpldi	443	18	both	both	DT
cord-302047-vv5gpldi	443	19	variants	variant	NNS
cord-302047-vv5gpldi	443	20	,	,	,
cord-302047-vv5gpldi	443	21	and	and	CC
cord-302047-vv5gpldi	443	22	virus	virus	NN
cord-302047-vv5gpldi	443	23	variant	variant	NN
cord-302047-vv5gpldi	443	24	with	with	IN
cord-302047-vv5gpldi	443	25	the	the	DT
cord-302047-vv5gpldi	443	26	deletion	deletion	NN
cord-302047-vv5gpldi	443	27	is	be	VBZ
cord-302047-vv5gpldi	443	28	selected	select	VBN
cord-302047-vv5gpldi	443	29	because	because	IN
cord-302047-vv5gpldi	443	30	those	those	DT
cord-302047-vv5gpldi	443	31	cells	cell	NNS
cord-302047-vv5gpldi	443	32	infected	infect	VBN
cord-302047-vv5gpldi	443	33	only	only	RB
cord-302047-vv5gpldi	443	34	with	with	IN
cord-302047-vv5gpldi	443	35	this	this	DT
cord-302047-vv5gpldi	443	36	variant	variant	NN
cord-302047-vv5gpldi	443	37	have	have	VBP
cord-302047-vv5gpldi	443	38	higher	high	JJR
cord-302047-vv5gpldi	443	39	replication	replication	NN
cord-302047-vv5gpldi	443	40	.	.	.
cord-302047-vv5gpldi	444	1	In	in	IN
cord-302047-vv5gpldi	444	2	panel	panel	NN
cord-302047-vv5gpldi	444	3	B	b	NN
cord-302047-vv5gpldi	444	4	,	,	,
cord-302047-vv5gpldi	444	5	the	the	DT
cord-302047-vv5gpldi	444	6	relationship	relationship	NN
cord-302047-vv5gpldi	444	7	between	between	IN
cord-302047-vv5gpldi	444	8	the	the	DT
cord-302047-vv5gpldi	444	9	cellular	cellular	JJ
cord-302047-vv5gpldi	444	10	MOI	MOI	NNP
cord-302047-vv5gpldi	444	11	(	(	-LRB-
cord-302047-vv5gpldi	444	12	ordinate	ordinate	NN
cord-302047-vv5gpldi	444	13	)	)	-RRB-
cord-302047-vv5gpldi	444	14	and	and	CC
cord-302047-vv5gpldi	444	15	the	the	DT
cord-302047-vv5gpldi	444	16	frequency	frequency	NN
cord-302047-vv5gpldi	444	17	of	of	IN
cord-302047-vv5gpldi	444	18	single	single	JJ
cord-302047-vv5gpldi	444	19	-	-	HYPH
cord-302047-vv5gpldi	444	20	genotype	genotype	NN
cord-302047-vv5gpldi	444	21	infection	infection	NN
cord-302047-vv5gpldi	444	22	(	(	-LRB-
cord-302047-vv5gpldi	444	23	abscissa	abscissa	NN
cord-302047-vv5gpldi	444	24	)	)	-RRB-
cord-302047-vv5gpldi	444	25	for	for	IN
cord-302047-vv5gpldi	444	26	a	a	DT
cord-302047-vv5gpldi	444	27	virus	virus	NN
cord-302047-vv5gpldi	444	28	population	population	NN
cord-302047-vv5gpldi	444	29	with	with	IN
cord-302047-vv5gpldi	444	30	genotypes	genotype	NNS
cord-302047-vv5gpldi	444	31	a	a	NNP
cord-302047-vv5gpldi	444	32	and	and	CC
cord-302047-vv5gpldi	444	33	b	b	NN
cord-302047-vv5gpldi	444	34	is	be	VBZ
cord-302047-vv5gpldi	444	35	given	give	VBN
cord-302047-vv5gpldi	444	36	,	,	,
cord-302047-vv5gpldi	444	37	for	for	IN
cord-302047-vv5gpldi	444	38	different	different	JJ
cord-302047-vv5gpldi	444	39	frequencies	frequency	NNS
cord-302047-vv5gpldi	444	40	of	of	IN
cord-302047-vv5gpldi	444	41	the	the	DT
cord-302047-vv5gpldi	444	42	two	two	CD
cord-302047-vv5gpldi	444	43	virus	virus	NN
cord-302047-vv5gpldi	444	44	genotypes	genotype	NNS
cord-302047-vv5gpldi	444	45	in	in	IN
cord-302047-vv5gpldi	444	46	the	the	DT
cord-302047-vv5gpldi	444	47	population	population	NN
cord-302047-vv5gpldi	444	48	(	(	-LRB-
cord-302047-vv5gpldi	444	49	f	f	LS
cord-302047-vv5gpldi	444	50	a	a	DT
cord-302047-vv5gpldi	444	51	shown	show	VBN
cord-302047-vv5gpldi	444	52	,	,	,
cord-302047-vv5gpldi	444	53	f	f	NNP
cord-302047-vv5gpldi	444	54	b	b	NNP
cord-302047-vv5gpldi	444	55	¼	¼	NNP
cord-302047-vv5gpldi	444	56	1	1	CD
cord-302047-vv5gpldi	444	57	-f	-f	SYM
cord-302047-vv5gpldi	444	58	a	a	NN
cord-302047-vv5gpldi	444	59	)	)	-RRB-
cord-302047-vv5gpldi	444	60	.	.	.
cord-302047-vv5gpldi	445	1	Note	note	VB
cord-302047-vv5gpldi	445	2	that	that	IN
cord-302047-vv5gpldi	445	3	the	the	DT
cord-302047-vv5gpldi	445	4	frequency	frequency	NN
cord-302047-vv5gpldi	445	5	of	of	IN
cord-302047-vv5gpldi	445	6	single	single	JJ
cord-302047-vv5gpldi	445	7	-	-	HYPH
cord-302047-vv5gpldi	445	8	genotype	genotype	NN
cord-302047-vv5gpldi	445	9	infections	infection	NNS
cord-302047-vv5gpldi	445	10	is	be	VBZ
cord-302047-vv5gpldi	445	11	given	give	VBN
cord-302047-vv5gpldi	445	12	as	as	IN
cord-302047-vv5gpldi	445	13	the	the	DT
cord-302047-vv5gpldi	445	14	proportion	proportion	NN
cord-302047-vv5gpldi	445	15	of	of	IN
cord-302047-vv5gpldi	445	16	infected	infected	JJ
cord-302047-vv5gpldi	445	17	cells	cell	NNS
cord-302047-vv5gpldi	445	18	in	in	IN
cord-302047-vv5gpldi	445	19	which	which	WDT
cord-302047-vv5gpldi	445	20	only	only	RB
cord-302047-vv5gpldi	445	21	virus	virus	NN
cord-302047-vv5gpldi	445	22	genotypes	genotype	NNS
cord-302047-vv5gpldi	445	23	a	a	VBP
cord-302047-vv5gpldi	445	24	or	or	CC
cord-302047-vv5gpldi	445	25	b	b	NN
cord-302047-vv5gpldi	445	26	are	be	VBP
cord-302047-vv5gpldi	445	27	present	present	JJ
cord-302047-vv5gpldi	445	28	.	.	.
cord-302047-vv5gpldi	446	1	As	as	IN
cord-302047-vv5gpldi	446	2	the	the	DT
cord-302047-vv5gpldi	446	3	MOI	MOI	NNP
cord-302047-vv5gpldi	446	4	increases	increase	VBZ
cord-302047-vv5gpldi	446	5	,	,	,
cord-302047-vv5gpldi	446	6	the	the	DT
cord-302047-vv5gpldi	446	7	frequency	frequency	NN
cord-302047-vv5gpldi	446	8	of	of	IN
cord-302047-vv5gpldi	446	9	single	single	JJ
cord-302047-vv5gpldi	446	10	-	-	HYPH
cord-302047-vv5gpldi	446	11	genotype	genotype	NN
cord-302047-vv5gpldi	446	12	infections	infection	NNS
cord-302047-vv5gpldi	446	13	decreases	decrease	VBZ
cord-302047-vv5gpldi	446	14	,	,	,
cord-302047-vv5gpldi	446	15	although	although	IN
cord-302047-vv5gpldi	446	16	it	-PRON-	PRP
cord-302047-vv5gpldi	446	17	depends	depend	VBZ
cord-302047-vv5gpldi	446	18	on	on	IN
cord-302047-vv5gpldi	446	19	the	the	DT
cord-302047-vv5gpldi	446	20	frequency	frequency	NN
cord-302047-vv5gpldi	446	21	of	of	IN
cord-302047-vv5gpldi	446	22	the	the	DT
cord-302047-vv5gpldi	446	23	two	two	CD
cord-302047-vv5gpldi	446	24	virus	virus	NN
cord-302047-vv5gpldi	446	25	genotypes	genotype	NNS
cord-302047-vv5gpldi	446	26	in	in	IN
cord-302047-vv5gpldi	446	27	the	the	DT
cord-302047-vv5gpldi	446	28	population	population	NN
cord-302047-vv5gpldi	446	29	.	.	.
cord-302047-vv5gpldi	447	1	If	if	IN
cord-302047-vv5gpldi	447	2	genotype	genotype	NN
cord-302047-vv5gpldi	447	3	a	a	NN
cord-302047-vv5gpldi	447	4	expresses	express	VBZ
cord-302047-vv5gpldi	447	5	a	a	DT
cord-302047-vv5gpldi	447	6	gene	gene	NN
cord-302047-vv5gpldi	447	7	that	that	WDT
cord-302047-vv5gpldi	447	8	has	have	VBZ
cord-302047-vv5gpldi	447	9	fitness	fitness	NN
cord-302047-vv5gpldi	447	10	costs	cost	NNS
cord-302047-vv5gpldi	447	11	that	that	WDT
cord-302047-vv5gpldi	447	12	act	act	VBP
cord-302047-vv5gpldi	447	13	in	in	IN
cord-302047-vv5gpldi	447	14	trans	trans	NNP
cord-302047-vv5gpldi	447	15	(	(	-LRB-
cord-302047-vv5gpldi	447	16	e.g.	e.g.	IN
cord-302047-vv5gpldi	447	17	toxicity	toxicity	NN
cord-302047-vv5gpldi	447	18	)	)	-RRB-
cord-302047-vv5gpldi	447	19	,	,	,
cord-302047-vv5gpldi	447	20	then	then	RB
cord-302047-vv5gpldi	447	21	selection	selection	NN
cord-302047-vv5gpldi	447	22	can	can	MD
cord-302047-vv5gpldi	447	23	only	only	RB
cord-302047-vv5gpldi	447	24	act	act	VB
cord-302047-vv5gpldi	447	25	against	against	IN
cord-302047-vv5gpldi	447	26	this	this	DT
cord-302047-vv5gpldi	447	27	genotype	genotype	NN
cord-302047-vv5gpldi	447	28	when	when	WRB
cord-302047-vv5gpldi	447	29	there	there	EX
cord-302047-vv5gpldi	447	30	is	be	VBZ
cord-302047-vv5gpldi	447	31	an	an	DT
cord-302047-vv5gpldi	447	32	appreciable	appreciable	JJ
cord-302047-vv5gpldi	447	33	number	number	NN
cord-302047-vv5gpldi	447	34	of	of	IN
cord-302047-vv5gpldi	447	35	singlegenotype	singlegenotype	NN
cord-302047-vv5gpldi	447	36	infections	infection	NNS
cord-302047-vv5gpldi	447	37	.	.	.
cord-302047-vv5gpldi	448	1	possible	possible	JJ
cord-302047-vv5gpldi	448	2	recombination	recombination	NN
cord-302047-vv5gpldi	448	3	events	event	NNS
cord-302047-vv5gpldi	448	4	that	that	WDT
cord-302047-vv5gpldi	448	5	partially	partially	RB
cord-302047-vv5gpldi	448	6	remove	remove	VBP
cord-302047-vv5gpldi	448	7	an	an	DT
cord-302047-vv5gpldi	448	8	insertion	insertion	NN
cord-302047-vv5gpldi	448	9	.	.	.
cord-302047-vv5gpldi	449	1	In	in	IN
cord-302047-vv5gpldi	449	2	contrast	contrast	NN
cord-302047-vv5gpldi	449	3	,	,	,
cord-302047-vv5gpldi	449	4	probably	probably	RB
cord-302047-vv5gpldi	449	5	only	only	RB
cord-302047-vv5gpldi	449	6	a	a	DT
cord-302047-vv5gpldi	449	7	small	small	JJ
cord-302047-vv5gpldi	449	8	fraction	fraction	NN
cord-302047-vv5gpldi	449	9	of	of	IN
cord-302047-vv5gpldi	449	10	point	point	NN
cord-302047-vv5gpldi	449	11	mutations	mutation	NNS
cord-302047-vv5gpldi	449	12	will	will	MD
cord-302047-vv5gpldi	449	13	be	be	VB
cord-302047-vv5gpldi	449	14	beneficial	beneficial	JJ
cord-302047-vv5gpldi	449	15	(	(	-LRB-
cord-302047-vv5gpldi	449	16	Sanjuá	Sanjuá	NNP
cord-302047-vv5gpldi	449	17	n	n	NNP
cord-302047-vv5gpldi	449	18	,	,	,
cord-302047-vv5gpldi	449	19	Moya	Moya	NNP
cord-302047-vv5gpldi	449	20	,	,	,
cord-302047-vv5gpldi	449	21	and	and	CC
cord-302047-vv5gpldi	449	22	Elena	Elena	NNP
cord-302047-vv5gpldi	449	23	2004	2004	CD
cord-302047-vv5gpldi	449	24	;	;	:
cord-302047-vv5gpldi	450	1	Carrasco	Carrasco	NNP
cord-302047-vv5gpldi	450	2	,	,	,
cord-302047-vv5gpldi	450	3	de	de	FW
cord-302047-vv5gpldi	450	4	la	la	FW
cord-302047-vv5gpldi	450	5	Iglesia	Iglesia	NNP
cord-302047-vv5gpldi	450	6	,	,	,
cord-302047-vv5gpldi	450	7	and	and	CC
cord-302047-vv5gpldi	450	8	Elena	Elena	NNP
cord-302047-vv5gpldi	450	9	2007	2007	CD
cord-302047-vv5gpldi	450	10	)	)	-RRB-
cord-302047-vv5gpldi	450	11	,	,	,
cord-302047-vv5gpldi	450	12	e.g.	e.g.	RB
cord-302047-vv5gpldi	450	13	in	in	IN
cord-302047-vv5gpldi	450	14	this	this	DT
cord-302047-vv5gpldi	450	15	case	case	NN
cord-302047-vv5gpldi	450	16	by	by	IN
cord-302047-vv5gpldi	450	17	lowering	lower	VBG
cord-302047-vv5gpldi	450	18	expression	expression	NN
cord-302047-vv5gpldi	450	19	of	of	IN
cord-302047-vv5gpldi	450	20	the	the	DT
cord-302047-vv5gpldi	450	21	inserted	insert	VBN
cord-302047-vv5gpldi	450	22	gene	gene	NN
cord-302047-vv5gpldi	450	23	or	or	CC
cord-302047-vv5gpldi	450	24	leading	lead	VBG
cord-302047-vv5gpldi	450	25	to	to	IN
cord-302047-vv5gpldi	450	26	more	more	RBR
cord-302047-vv5gpldi	450	27	favorable	favorable	JJ
cord-302047-vv5gpldi	450	28	codon	codon	NN
cord-302047-vv5gpldi	450	29	usage	usage	NN
cord-302047-vv5gpldi	450	30	.	.	.
cord-302047-vv5gpldi	451	1	We	-PRON-	PRP
cord-302047-vv5gpldi	451	2	therefore	therefore	RB
cord-302047-vv5gpldi	451	3	conjecture	conjecture	VBP
cord-302047-vv5gpldi	451	4	that	that	IN
cord-302047-vv5gpldi	451	5	mutation	mutation	NN
cord-302047-vv5gpldi	451	6	supply	supply	NN
cord-302047-vv5gpldi	451	7	is	be	VBZ
cord-302047-vv5gpldi	451	8	likely	likely	JJ
cord-302047-vv5gpldi	451	9	to	to	TO
cord-302047-vv5gpldi	451	10	favor	favor	VB
cord-302047-vv5gpldi	451	11	the	the	DT
cord-302047-vv5gpldi	451	12	evolution	evolution	NN
cord-302047-vv5gpldi	451	13	of	of	IN
cord-302047-vv5gpldi	451	14	deletions	deletion	NNS
cord-302047-vv5gpldi	451	15	in	in	IN
cord-302047-vv5gpldi	451	16	the	the	DT
cord-302047-vv5gpldi	451	17	transgene	transgene	NN
cord-302047-vv5gpldi	451	18	over	over	IN
cord-302047-vv5gpldi	451	19	beneficial	beneficial	JJ
cord-302047-vv5gpldi	451	20	point	point	NN
cord-302047-vv5gpldi	451	21	mutations	mutation	NNS
cord-302047-vv5gpldi	451	22	that	that	WDT
cord-302047-vv5gpldi	451	23	affect	affect	VBP
cord-302047-vv5gpldi	451	24	fitness	fitness	NN
cord-302047-vv5gpldi	451	25	cost	cost	NN
cord-302047-vv5gpldi	451	26	.	.	.
cord-302047-vv5gpldi	452	1	Consider	consider	VB
cord-302047-vv5gpldi	452	2	the	the	DT
cord-302047-vv5gpldi	452	3	'	'	``
cord-302047-vv5gpldi	452	4	genomic	genomic	JJ
cord-302047-vv5gpldi	452	5	accordion	accordion	NN
cord-302047-vv5gpldi	452	6	'	'	''
cord-302047-vv5gpldi	452	7	observed	observe	VBN
cord-302047-vv5gpldi	452	8	in	in	IN
cord-302047-vv5gpldi	452	9	poxviruses	poxvirus	NNS
cord-302047-vv5gpldi	452	10	(	(	-LRB-
cord-302047-vv5gpldi	452	11	Elde	Elde	NNP
cord-302047-vv5gpldi	452	12	et	et	NNP
cord-302047-vv5gpldi	452	13	al	al	NNP
cord-302047-vv5gpldi	452	14	.	.	.
cord-302047-vv5gpldi	452	15	2012	2012	CD
cord-302047-vv5gpldi	452	16	)	)	-RRB-
cord-302047-vv5gpldi	452	17	:	:	:
cord-302047-vv5gpldi	452	18	beneficial	beneficial	JJ
cord-302047-vv5gpldi	452	19	point	point	NN
cord-302047-vv5gpldi	452	20	mutations	mutation	NNS
cord-302047-vv5gpldi	452	21	typically	typically	RB
cord-302047-vv5gpldi	452	22	occur	occur	VBP
cord-302047-vv5gpldi	452	23	long	long	RB
cord-302047-vv5gpldi	452	24	after	after	IN
cord-302047-vv5gpldi	452	25	gene	gene	NN
cord-302047-vv5gpldi	452	26	amplification	amplification	NN
cord-302047-vv5gpldi	452	27	by	by	IN
cord-302047-vv5gpldi	452	28	copy	copy	NN
cord-302047-vv5gpldi	452	29	number	number	NN
cord-302047-vv5gpldi	452	30	variation	variation	NN
cord-302047-vv5gpldi	452	31	.	.	.
cord-302047-vv5gpldi	453	1	Likewise	likewise	RB
cord-302047-vv5gpldi	453	2	we	-PRON-	PRP
cord-302047-vv5gpldi	453	3	expect	expect	VBP
cord-302047-vv5gpldi	453	4	deletions	deletion	NNS
cord-302047-vv5gpldi	453	5	that	that	WDT
cord-302047-vv5gpldi	453	6	remove	remove	VBP
cord-302047-vv5gpldi	453	7	an	an	DT
cord-302047-vv5gpldi	453	8	insertion	insertion	NN
cord-302047-vv5gpldi	453	9	to	to	TO
cord-302047-vv5gpldi	453	10	be	be	VB
cord-302047-vv5gpldi	453	11	fixed	fix	VBN
cord-302047-vv5gpldi	453	12	before	before	IN
cord-302047-vv5gpldi	453	13	point	point	NN
cord-302047-vv5gpldi	453	14	mutations	mutation	NNS
cord-302047-vv5gpldi	453	15	that	that	WDT
cord-302047-vv5gpldi	453	16	also	also	RB
cord-302047-vv5gpldi	453	17	lessen	lessen	VBP
cord-302047-vv5gpldi	453	18	its	-PRON-	PRP$
cord-302047-vv5gpldi	453	19	impact	impact	NN
cord-302047-vv5gpldi	453	20	occur	occur	VB
cord-302047-vv5gpldi	453	21	.	.	.
cord-302047-vv5gpldi	454	1	Nevertheless	nevertheless	RB
cord-302047-vv5gpldi	454	2	,	,	,
cord-302047-vv5gpldi	454	3	the	the	DT
cord-302047-vv5gpldi	454	4	occurrence	occurrence	NN
cord-302047-vv5gpldi	454	5	of	of	IN
cord-302047-vv5gpldi	454	6	alternative	alternative	JJ
cord-302047-vv5gpldi	454	7	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	454	8	trajectories	trajectory	NNS
cord-302047-vv5gpldi	454	9	could	could	MD
cord-302047-vv5gpldi	454	10	,	,	,
cord-302047-vv5gpldi	454	11	depending	depend	VBG
cord-302047-vv5gpldi	454	12	on	on	IN
cord-302047-vv5gpldi	454	13	the	the	DT
cord-302047-vv5gpldi	454	14	exact	exact	JJ
cord-302047-vv5gpldi	454	15	mutation	mutation	NN
cord-302047-vv5gpldi	454	16	supply	supply	NN
cord-302047-vv5gpldi	454	17	and	and	CC
cord-302047-vv5gpldi	454	18	effect	effect	NN
cord-302047-vv5gpldi	454	19	sizes	size	NNS
cord-302047-vv5gpldi	454	20	for	for	IN
cord-302047-vv5gpldi	454	21	different	different	JJ
cord-302047-vv5gpldi	454	22	classes	class	NNS
cord-302047-vv5gpldi	454	23	of	of	IN
cord-302047-vv5gpldi	454	24	mutations	mutation	NNS
cord-302047-vv5gpldi	454	25	,	,	,
cord-302047-vv5gpldi	454	26	contribute	contribute	VBP
cord-302047-vv5gpldi	454	27	to	to	IN
cord-302047-vv5gpldi	454	28	making	make	VBG
cord-302047-vv5gpldi	454	29	stability	stability	NN
cord-302047-vv5gpldi	454	30	of	of	IN
cord-302047-vv5gpldi	454	31	genomic	genomic	JJ
cord-302047-vv5gpldi	454	32	inserts	insert	NNS
cord-302047-vv5gpldi	454	33	less	less	RBR
cord-302047-vv5gpldi	454	34	repeatable	repeatable	JJ
cord-302047-vv5gpldi	454	35	and	and	CC
cord-302047-vv5gpldi	454	36	predictable	predictable	JJ
cord-302047-vv5gpldi	454	37	in	in	IN
cord-302047-vv5gpldi	454	38	some	some	DT
cord-302047-vv5gpldi	454	39	cases	case	NNS
cord-302047-vv5gpldi	454	40	(	(	-LRB-
cord-302047-vv5gpldi	454	41	De	De	NNP
cord-302047-vv5gpldi	454	42	Visser	Visser	NNP
cord-302047-vv5gpldi	454	43	and	and	CC
cord-302047-vv5gpldi	454	44	Krug	Krug	NNP
cord-302047-vv5gpldi	454	45	2014	2014	CD
cord-302047-vv5gpldi	454	46	;	;	:
cord-302047-vv5gpldi	454	47	Bolnick	Bolnick	NNP
cord-302047-vv5gpldi	454	48	et	et	NNP
cord-302047-vv5gpldi	454	49	al	al	NNP
cord-302047-vv5gpldi	454	50	.	.	.
cord-302047-vv5gpldi	454	51	2018	2018	CD
cord-302047-vv5gpldi	454	52	)	)	-RRB-
cord-302047-vv5gpldi	454	53	.	.	.
cord-302047-vv5gpldi	455	1	Whereas	whereas	IN
cord-302047-vv5gpldi	455	2	some	some	DT
cord-302047-vv5gpldi	455	3	sequences	sequence	NNS
cord-302047-vv5gpldi	455	4	inserted	insert	VBN
cord-302047-vv5gpldi	455	5	into	into	IN
cord-302047-vv5gpldi	455	6	viral	viral	JJ
cord-302047-vv5gpldi	455	7	genomes	genome	NNS
cord-302047-vv5gpldi	455	8	are	be	VBP
cord-302047-vv5gpldi	455	9	stable	stable	JJ
cord-302047-vv5gpldi	455	10	,	,	,
cord-302047-vv5gpldi	455	11	others	other	NNS
cord-302047-vv5gpldi	455	12	are	be	VBP
cord-302047-vv5gpldi	455	13	clearly	clearly	RB
cord-302047-vv5gpldi	455	14	not	not	RB
cord-302047-vv5gpldi	455	15	.	.	.
cord-302047-vv5gpldi	456	1	Although	although	IN
cord-302047-vv5gpldi	456	2	there	there	EX
cord-302047-vv5gpldi	456	3	are	be	VBP
cord-302047-vv5gpldi	456	4	some	some	DT
cord-302047-vv5gpldi	456	5	factors	factor	NNS
cord-302047-vv5gpldi	456	6	that	that	WDT
cord-302047-vv5gpldi	456	7	appear	appear	VBP
cord-302047-vv5gpldi	456	8	to	to	TO
cord-302047-vv5gpldi	456	9	explain	explain	VB
cord-302047-vv5gpldi	456	10	these	these	DT
cord-302047-vv5gpldi	456	11	differences	difference	NNS
cord-302047-vv5gpldi	456	12	,	,	,
cord-302047-vv5gpldi	456	13	at	at	IN
cord-302047-vv5gpldi	456	14	the	the	DT
cord-302047-vv5gpldi	456	15	end	end	NN
cord-302047-vv5gpldi	456	16	of	of	IN
cord-302047-vv5gpldi	456	17	the	the	DT
cord-302047-vv5gpldi	456	18	day	day	NN
cord-302047-vv5gpldi	456	19	there	there	EX
cord-302047-vv5gpldi	456	20	is	be	VBZ
cord-302047-vv5gpldi	456	21	still	still	RB
cord-302047-vv5gpldi	456	22	a	a	DT
cord-302047-vv5gpldi	456	23	great	great	JJ
cord-302047-vv5gpldi	456	24	deal	deal	NN
cord-302047-vv5gpldi	456	25	about	about	IN
cord-302047-vv5gpldi	456	26	the	the	DT
cord-302047-vv5gpldi	456	27	relatively	relatively	RB
cord-302047-vv5gpldi	456	28	simple	simple	JJ
cord-302047-vv5gpldi	456	29	question	question	NN
cord-302047-vv5gpldi	456	30	of	of	IN
cord-302047-vv5gpldi	456	31	stability	stability	NN
cord-302047-vv5gpldi	456	32	that	that	WDT
cord-302047-vv5gpldi	456	33	we	-PRON-	PRP
cord-302047-vv5gpldi	456	34	do	do	VBP
cord-302047-vv5gpldi	456	35	not	not	RB
cord-302047-vv5gpldi	456	36	understand	understand	VB
cord-302047-vv5gpldi	456	37	.	.	.
cord-302047-vv5gpldi	457	1	In	in	IN
cord-302047-vv5gpldi	457	2	contrast	contrast	NN
cord-302047-vv5gpldi	457	3	,	,	,
cord-302047-vv5gpldi	457	4	these	these	DT
cord-302047-vv5gpldi	457	5	different	different	JJ
cord-302047-vv5gpldi	457	6	outcomes	outcome	NNS
cord-302047-vv5gpldi	457	7	are	be	VBP
cord-302047-vv5gpldi	457	8	encouraging	encouraging	JJ
cord-302047-vv5gpldi	457	9	,	,	,
cord-302047-vv5gpldi	457	10	because	because	IN
cord-302047-vv5gpldi	457	11	they	-PRON-	PRP
cord-302047-vv5gpldi	457	12	suggest	suggest	VBP
cord-302047-vv5gpldi	457	13	that	that	IN
cord-302047-vv5gpldi	457	14	if	if	IN
cord-302047-vv5gpldi	457	15	we	-PRON-	PRP
cord-302047-vv5gpldi	457	16	understand	understand	VBP
cord-302047-vv5gpldi	457	17	the	the	DT
cord-302047-vv5gpldi	457	18	process	process	NN
cord-302047-vv5gpldi	457	19	well	well	RB
cord-302047-vv5gpldi	457	20	enough	enough	RB
cord-302047-vv5gpldi	457	21	,	,	,
cord-302047-vv5gpldi	457	22	we	-PRON-	PRP
cord-302047-vv5gpldi	457	23	can	can	MD
cord-302047-vv5gpldi	457	24	design	design	VB
cord-302047-vv5gpldi	457	25	more	more	RBR
cord-302047-vv5gpldi	457	26	stable	stable	JJ
cord-302047-vv5gpldi	457	27	insertions	insertion	NNS
cord-302047-vv5gpldi	457	28	.	.	.
cord-302047-vv5gpldi	458	1	For	for	IN
cord-302047-vv5gpldi	458	2	most	most	JJS
cord-302047-vv5gpldi	458	3	viruses	virus	NNS
cord-302047-vv5gpldi	458	4	,	,	,
cord-302047-vv5gpldi	458	5	strong	strong	JJ
cord-302047-vv5gpldi	458	6	selective	selective	JJ
cord-302047-vv5gpldi	458	7	constraints	constraint	NNS
cord-302047-vv5gpldi	458	8	appear	appear	VBP
cord-302047-vv5gpldi	458	9	to	to	TO
cord-302047-vv5gpldi	458	10	exist	exist	VB
cord-302047-vv5gpldi	458	11	against	against	IN
cord-302047-vv5gpldi	458	12	increasing	increase	VBG
cord-302047-vv5gpldi	458	13	genome	genome	NN
cord-302047-vv5gpldi	458	14	size	size	NN
cord-302047-vv5gpldi	458	15	.	.	.
cord-302047-vv5gpldi	459	1	In	in	IN
cord-302047-vv5gpldi	459	2	natural	natural	JJ
cord-302047-vv5gpldi	459	3	conditions	condition	NNS
cord-302047-vv5gpldi	459	4	,	,	,
cord-302047-vv5gpldi	459	5	this	this	DT
cord-302047-vv5gpldi	459	6	is	be	VBZ
cord-302047-vv5gpldi	459	7	an	an	DT
cord-302047-vv5gpldi	459	8	impediment	impediment	NN
cord-302047-vv5gpldi	459	9	for	for	IN
cord-302047-vv5gpldi	459	10	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	459	11	innovation	innovation	NN
cord-302047-vv5gpldi	459	12	by	by	IN
cord-302047-vv5gpldi	459	13	gene	gene	NN
cord-302047-vv5gpldi	459	14	duplication	duplication	NN
cord-302047-vv5gpldi	459	15	or	or	CC
cord-302047-vv5gpldi	459	16	HGT	HGT	NNP
cord-302047-vv5gpldi	459	17	.	.	.
cord-302047-vv5gpldi	460	1	In	in	IN
cord-302047-vv5gpldi	460	2	laboratory	laboratory	NN
cord-302047-vv5gpldi	460	3	conditions	condition	NNS
cord-302047-vv5gpldi	460	4	,	,	,
cord-302047-vv5gpldi	460	5	this	this	DT
cord-302047-vv5gpldi	460	6	is	be	VBZ
cord-302047-vv5gpldi	460	7	an	an	DT
cord-302047-vv5gpldi	460	8	impediment	impediment	NN
cord-302047-vv5gpldi	460	9	for	for	IN
cord-302047-vv5gpldi	460	10	expressing	express	VBG
cord-302047-vv5gpldi	460	11	a	a	DT
cord-302047-vv5gpldi	460	12	gene	gene	NN
cord-302047-vv5gpldi	460	13	of	of	IN
cord-302047-vv5gpldi	460	14	interest	interest	NN
cord-302047-vv5gpldi	460	15	by	by	IN
cord-302047-vv5gpldi	460	16	using	use	VBG
cord-302047-vv5gpldi	460	17	engineered	engineer	VBN
cord-302047-vv5gpldi	460	18	viral	viral	JJ
cord-302047-vv5gpldi	460	19	vectors	vector	NNS
cord-302047-vv5gpldi	460	20	.	.	.
cord-302047-vv5gpldi	461	1	When	when	WRB
cord-302047-vv5gpldi	461	2	stratifying	stratify	VBG
cord-302047-vv5gpldi	461	3	by	by	IN
cord-302047-vv5gpldi	461	4	viral	viral	JJ
cord-302047-vv5gpldi	461	5	groups	group	NNS
cord-302047-vv5gpldi	461	6	,	,	,
cord-302047-vv5gpldi	461	7	we	-PRON-	PRP
cord-302047-vv5gpldi	461	8	observe	observe	VBP
cord-302047-vv5gpldi	461	9	that	that	IN
cord-302047-vv5gpldi	461	10	the	the	DT
cord-302047-vv5gpldi	461	11	stability	stability	NN
cord-302047-vv5gpldi	461	12	of	of	IN
cord-302047-vv5gpldi	461	13	viral	viral	JJ
cord-302047-vv5gpldi	461	14	genomes	genome	NNS
cord-302047-vv5gpldi	461	15	partially	partially	RB
cord-302047-vv5gpldi	461	16	depends	depend	VBZ
cord-302047-vv5gpldi	461	17	on	on	IN
cord-302047-vv5gpldi	461	18	the	the	DT
cord-302047-vv5gpldi	461	19	nature	nature	NN
cord-302047-vv5gpldi	461	20	of	of	IN
cord-302047-vv5gpldi	461	21	the	the	DT
cord-302047-vv5gpldi	461	22	genome	genome	NN
cord-302047-vv5gpldi	461	23	.	.	.
cord-302047-vv5gpldi	462	1	Viral	viral	JJ
cord-302047-vv5gpldi	462	2	genomes	genome	NNS
cord-302047-vv5gpldi	462	3	with	with	IN
cord-302047-vv5gpldi	462	4	separately	separately	RB
cord-302047-vv5gpldi	462	5	expressed	express	VBN
cord-302047-vv5gpldi	462	6	nonoverlapping	nonoverlappe	VBG
cord-302047-vv5gpldi	462	7	ORFs	ORFs	NNP
cord-302047-vv5gpldi	462	8	(	(	-LRB-
cord-302047-vv5gpldi	462	9	group	group	NN
cord-302047-vv5gpldi	462	10	V	v	NN
cord-302047-vv5gpldi	462	11	:	:	:
cord-302047-vv5gpldi	462	12	ssRNAÀ	ssRNAÀ	NFP
cord-302047-vv5gpldi	462	13	)	)	-RRB-
cord-302047-vv5gpldi	462	14	appear	appear	VBP
cord-302047-vv5gpldi	462	15	to	to	TO
cord-302047-vv5gpldi	462	16	have	have	VB
cord-302047-vv5gpldi	462	17	less	less	JJR
cord-302047-vv5gpldi	462	18	constraints	constraint	NNS
cord-302047-vv5gpldi	462	19	imposed	impose	VBN
cord-302047-vv5gpldi	462	20	on	on	IN
cord-302047-vv5gpldi	462	21	sequence	sequence	NN
cord-302047-vv5gpldi	462	22	insertions	insertion	NNS
cord-302047-vv5gpldi	462	23	as	as	IN
cord-302047-vv5gpldi	462	24	compared	compare	VBN
cord-302047-vv5gpldi	462	25	to	to	IN
cord-302047-vv5gpldi	462	26	genomes	genome	NNS
cord-302047-vv5gpldi	462	27	with	with	IN
cord-302047-vv5gpldi	462	28	genes	gene	NNS
cord-302047-vv5gpldi	462	29	encoded	encode	VBN
cord-302047-vv5gpldi	462	30	in	in	IN
cord-302047-vv5gpldi	462	31	one	one	CD
cord-302047-vv5gpldi	462	32	single	single	JJ
cord-302047-vv5gpldi	462	33	ORF	ORF	NNP
cord-302047-vv5gpldi	462	34	(	(	-LRB-
cord-302047-vv5gpldi	462	35	group	group	NN
cord-302047-vv5gpldi	462	36	IV	IV	NNP
cord-302047-vv5gpldi	462	37	:	:	:
cord-302047-vv5gpldi	462	38	ssRNAþ	ssRNAþ	NNP
cord-302047-vv5gpldi	462	39	)	)	-RRB-
cord-302047-vv5gpldi	462	40	.	.	.
cord-302047-vv5gpldi	463	1	Although	although	IN
cord-302047-vv5gpldi	463	2	the	the	DT
cord-302047-vv5gpldi	463	3	dsDNA	dsdna	NN
cord-302047-vv5gpldi	464	1	(	(	-LRB-
cord-302047-vv5gpldi	464	2	group	group	NN
cord-302047-vv5gpldi	464	3	I	I	NNP
cord-302047-vv5gpldi	464	4	)	)	-RRB-
cord-302047-vv5gpldi	464	5	virus	virus	NN
cord-302047-vv5gpldi	464	6	genomes	genome	NNS
cord-302047-vv5gpldi	464	7	are	be	VBP
cord-302047-vv5gpldi	464	8	extremely	extremely	RB
cord-302047-vv5gpldi	464	9	plastic	plastic	JJ
cord-302047-vv5gpldi	464	10	in	in	IN
cord-302047-vv5gpldi	464	11	natural	natural	JJ
cord-302047-vv5gpldi	464	12	conditions	condition	NNS
cord-302047-vv5gpldi	464	13	,	,	,
cord-302047-vv5gpldi	464	14	this	this	DT
cord-302047-vv5gpldi	464	15	observation	observation	NN
cord-302047-vv5gpldi	464	16	is	be	VBZ
cord-302047-vv5gpldi	464	17	not	not	RB
cord-302047-vv5gpldi	464	18	a	a	DT
cord-302047-vv5gpldi	464	19	good	good	JJ
cord-302047-vv5gpldi	464	20	predictor	predictor	NN
cord-302047-vv5gpldi	464	21	for	for	IN
cord-302047-vv5gpldi	464	22	stability	stability	NN
cord-302047-vv5gpldi	464	23	of	of	IN
cord-302047-vv5gpldi	464	24	engineered	engineer	VBN
cord-302047-vv5gpldi	464	25	viral	viral	JJ
cord-302047-vv5gpldi	464	26	genomes	genome	NNS
cord-302047-vv5gpldi	464	27	as	as	IN
cord-302047-vv5gpldi	464	28	inserts	insert	NNS
cord-302047-vv5gpldi	464	29	are	be	VBP
cord-302047-vv5gpldi	464	30	generally	generally	RB
cord-302047-vv5gpldi	464	31	lost	lose	VBN
cord-302047-vv5gpldi	464	32	.	.	.
cord-302047-vv5gpldi	465	1	In	in	IN
cord-302047-vv5gpldi	465	2	the	the	DT
cord-302047-vv5gpldi	465	3	case	case	NN
cord-302047-vv5gpldi	465	4	of	of	IN
cord-302047-vv5gpldi	465	5	ssDNA	ssdna	NN
cord-302047-vv5gpldi	465	6	(	(	-LRB-
cord-302047-vv5gpldi	465	7	group	group	NN
cord-302047-vv5gpldi	465	8	II	II	NNP
cord-302047-vv5gpldi	465	9	)	)	-RRB-
cord-302047-vv5gpldi	465	10	viruses	virus	NNS
cord-302047-vv5gpldi	465	11	,	,	,
cord-302047-vv5gpldi	465	12	the	the	DT
cord-302047-vv5gpldi	465	13	varying	vary	VBG
cord-302047-vv5gpldi	465	14	frequency	frequency	NN
cord-302047-vv5gpldi	465	15	of	of	IN
cord-302047-vv5gpldi	465	16	genomic	genomic	JJ
cord-302047-vv5gpldi	465	17	segments	segment	NNS
cord-302047-vv5gpldi	465	18	might	may	MD
cord-302047-vv5gpldi	465	19	lead	lead	VB
cord-302047-vv5gpldi	465	20	to	to	IN
cord-302047-vv5gpldi	465	21	rapid	rapid	JJ
cord-302047-vv5gpldi	465	22	adaptive	adaptive	JJ
cord-302047-vv5gpldi	465	23	responses	response	NNS
cord-302047-vv5gpldi	465	24	to	to	IN
cord-302047-vv5gpldi	465	25	inserted	insert	VBN
cord-302047-vv5gpldi	465	26	sequences	sequence	NNS
cord-302047-vv5gpldi	465	27	.	.	.
cord-302047-vv5gpldi	466	1	While	while	IN
cord-302047-vv5gpldi	466	2	in	in	IN
cord-302047-vv5gpldi	466	3	the	the	DT
cord-302047-vv5gpldi	466	4	case	case	NN
cord-302047-vv5gpldi	466	5	of	of	IN
cord-302047-vv5gpldi	466	6	segmented	segmented	JJ
cord-302047-vv5gpldi	466	7	dsRNA	dsrna	NN
cord-302047-vv5gpldi	466	8	(	(	-LRB-
cord-302047-vv5gpldi	466	9	group	group	NN
cord-302047-vv5gpldi	466	10	III	III	NNP
cord-302047-vv5gpldi	466	11	)	)	-RRB-
cord-302047-vv5gpldi	466	12	viruses	virus	NNS
cord-302047-vv5gpldi	466	13	,	,	,
cord-302047-vv5gpldi	466	14	sequence	sequence	NN
cord-302047-vv5gpldi	466	15	insertions	insertion	NNS
cord-302047-vv5gpldi	466	16	probably	probably	RB
cord-302047-vv5gpldi	466	17	perturb	perturb	VBP
cord-302047-vv5gpldi	466	18	segmented	segmented	JJ
cord-302047-vv5gpldi	466	19	genome	genome	NN
cord-302047-vv5gpldi	466	20	assembly	assembly	NN
cord-302047-vv5gpldi	466	21	.	.	.
cord-302047-vv5gpldi	467	1	When	when	WRB
cord-302047-vv5gpldi	467	2	comparing	compare	VBG
cord-302047-vv5gpldi	467	3	the	the	DT
cord-302047-vv5gpldi	467	4	retro	retro	NN
cord-302047-vv5gpldi	467	5	-	-	HYPH
cord-302047-vv5gpldi	467	6	transcribing	transcribe	VBG
cord-302047-vv5gpldi	467	7	viruses	virus	NNS
cord-302047-vv5gpldi	467	8	,	,	,
cord-302047-vv5gpldi	467	9	the	the	DT
cord-302047-vv5gpldi	467	10	RT	RT	NNP
cord-302047-vv5gpldi	467	11	-	-	HYPH
cord-302047-vv5gpldi	467	12	ssRNA(þ	ssRNA(þ	NNP
cord-302047-vv5gpldi	467	13	)	)	-RRB-
cord-302047-vv5gpldi	468	1	(	(	-LRB-
cord-302047-vv5gpldi	468	2	group	group	NN
cord-302047-vv5gpldi	468	3	VI	VI	NNP
cord-302047-vv5gpldi	468	4	)	)	-RRB-
cord-302047-vv5gpldi	469	1	viruses	virus	NNS
cord-302047-vv5gpldi	469	2	appear	appear	VBP
cord-302047-vv5gpldi	469	3	to	to	TO
cord-302047-vv5gpldi	469	4	successfully	successfully	RB
cord-302047-vv5gpldi	469	5	express	express	VB
cord-302047-vv5gpldi	469	6	sequences	sequence	NNS
cord-302047-vv5gpldi	469	7	of	of	IN
cord-302047-vv5gpldi	469	8	interest	interest	NN
cord-302047-vv5gpldi	469	9	after	after	IN
cord-302047-vv5gpldi	469	10	stable	stable	JJ
cord-302047-vv5gpldi	469	11	integration	integration	NN
cord-302047-vv5gpldi	469	12	into	into	IN
cord-302047-vv5gpldi	469	13	the	the	DT
cord-302047-vv5gpldi	469	14	host	host	NN
cord-302047-vv5gpldi	469	15	genome	genome	NN
cord-302047-vv5gpldi	469	16	,	,	,
cord-302047-vv5gpldi	469	17	whilst	whilst	IN
cord-302047-vv5gpldi	469	18	the	the	DT
cord-302047-vv5gpldi	469	19	RT	RT	NNP
cord-302047-vv5gpldi	469	20	-	-	HYPH
cord-302047-vv5gpldi	469	21	dsDNA	dsdna	JJ
cord-302047-vv5gpldi	469	22	(	(	-LRB-
cord-302047-vv5gpldi	469	23	group	group	NN
cord-302047-vv5gpldi	469	24	VII	VII	NNP
cord-302047-vv5gpldi	469	25	)	)	-RRB-
cord-302047-vv5gpldi	469	26	viruses	virus	NNS
cord-302047-vv5gpldi	469	27	are	be	VBP
cord-302047-vv5gpldi	469	28	less	less	RBR
cord-302047-vv5gpldi	469	29	stable	stable	JJ
cord-302047-vv5gpldi	469	30	and	and	CC
cord-302047-vv5gpldi	469	31	only	only	RB
cord-302047-vv5gpldi	469	32	rarely	rarely	RB
cord-302047-vv5gpldi	469	33	integrate	integrate	VBP
cord-302047-vv5gpldi	469	34	into	into	IN
cord-302047-vv5gpldi	469	35	the	the	DT
cord-302047-vv5gpldi	469	36	host	host	NN
cord-302047-vv5gpldi	469	37	genome	genome	NN
cord-302047-vv5gpldi	469	38	.	.	.
cord-302047-vv5gpldi	470	1	Multipartite	Multipartite	NNP
cord-302047-vv5gpldi	470	2	viruses	virus	NNS
cord-302047-vv5gpldi	470	3	,	,	,
cord-302047-vv5gpldi	470	4	represented	represent	VBN
cord-302047-vv5gpldi	470	5	in	in	IN
cord-302047-vv5gpldi	470	6	various	various	JJ
cord-302047-vv5gpldi	470	7	groups	group	NNS
cord-302047-vv5gpldi	470	8	,	,	,
cord-302047-vv5gpldi	470	9	also	also	RB
cord-302047-vv5gpldi	470	10	present	present	VBP
cord-302047-vv5gpldi	470	11	unique	unique	JJ
cord-302047-vv5gpldi	470	12	challenges	challenge	NNS
cord-302047-vv5gpldi	470	13	when	when	WRB
cord-302047-vv5gpldi	470	14	thinking	think	VBG
cord-302047-vv5gpldi	470	15	about	about	IN
cord-302047-vv5gpldi	470	16	the	the	DT
cord-302047-vv5gpldi	470	17	stability	stability	NN
cord-302047-vv5gpldi	470	18	of	of	IN
cord-302047-vv5gpldi	470	19	inserted	insert	VBN
cord-302047-vv5gpldi	470	20	sequences	sequence	NNS
cord-302047-vv5gpldi	470	21	.	.	.
cord-302047-vv5gpldi	471	1	When	when	WRB
cord-302047-vv5gpldi	471	2	comparing	compare	VBG
cord-302047-vv5gpldi	471	3	all	all	DT
cord-302047-vv5gpldi	471	4	viral	viral	JJ
cord-302047-vv5gpldi	471	5	genome	genome	NN
cord-302047-vv5gpldi	471	6	architectures	architecture	NNS
cord-302047-vv5gpldi	471	7	,	,	,
cord-302047-vv5gpldi	471	8	we	-PRON-	PRP
cord-302047-vv5gpldi	471	9	conclude	conclude	VBP
cord-302047-vv5gpldi	471	10	that	that	IN
cord-302047-vv5gpldi	471	11	that	that	DT
cord-302047-vv5gpldi	471	12	genomic	genomic	JJ
cord-302047-vv5gpldi	471	13	stability	stability	NN
cord-302047-vv5gpldi	471	14	is	be	VBZ
cord-302047-vv5gpldi	471	15	not	not	RB
cord-302047-vv5gpldi	471	16	a	a	DT
cord-302047-vv5gpldi	471	17	fixed	fix	VBN
cord-302047-vv5gpldi	471	18	,	,	,
cord-302047-vv5gpldi	471	19	intrinsic	intrinsic	JJ
cord-302047-vv5gpldi	471	20	property	property	NN
cord-302047-vv5gpldi	471	21	.	.	.
cord-302047-vv5gpldi	472	1	Although	although	IN
cord-302047-vv5gpldi	472	2	we	-PRON-	PRP
cord-302047-vv5gpldi	472	3	show	show	VBP
cord-302047-vv5gpldi	472	4	that	that	IN
cord-302047-vv5gpldi	472	5	insert	insert	VBP
cord-302047-vv5gpldi	472	6	stability	stability	NN
cord-302047-vv5gpldi	472	7	depends	depend	VBZ
cord-302047-vv5gpldi	472	8	on	on	IN
cord-302047-vv5gpldi	472	9	the	the	DT
cord-302047-vv5gpldi	472	10	nature	nature	NN
cord-302047-vv5gpldi	472	11	of	of	IN
cord-302047-vv5gpldi	472	12	the	the	DT
cord-302047-vv5gpldi	472	13	genome	genome	NN
cord-302047-vv5gpldi	472	14	,	,	,
cord-302047-vv5gpldi	472	15	the	the	DT
cord-302047-vv5gpldi	472	16	site	site	NN
cord-302047-vv5gpldi	472	17	and	and	CC
cord-302047-vv5gpldi	472	18	size	size	NN
cord-302047-vv5gpldi	472	19	of	of	IN
cord-302047-vv5gpldi	472	20	the	the	DT
cord-302047-vv5gpldi	472	21	insert	insert	NN
cord-302047-vv5gpldi	472	22	and	and	CC
cord-302047-vv5gpldi	472	23	the	the	DT
cord-302047-vv5gpldi	472	24	recombination	recombination	NN
cord-302047-vv5gpldi	472	25	rate	rate	NN
cord-302047-vv5gpldi	472	26	,	,	,
cord-302047-vv5gpldi	472	27	the	the	DT
cord-302047-vv5gpldi	472	28	host	host	NN
cord-302047-vv5gpldi	472	29	species	specie	NNS
cord-302047-vv5gpldi	472	30	and	and	CC
cord-302047-vv5gpldi	472	31	demographic	demographic	JJ
cord-302047-vv5gpldi	472	32	conditions	condition	NNS
cord-302047-vv5gpldi	472	33	(	(	-LRB-
cord-302047-vv5gpldi	472	34	i.e.	i.e.	FW
cord-302047-vv5gpldi	472	35	population	population	NN
cord-302047-vv5gpldi	472	36	and	and	CC
cord-302047-vv5gpldi	472	37	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	472	38	size	size	NN
cord-302047-vv5gpldi	472	39	)	)	-RRB-
cord-302047-vv5gpldi	472	40	can	can	MD
cord-302047-vv5gpldi	472	41	radically	radically	RB
cord-302047-vv5gpldi	472	42	change	change	VB
cord-302047-vv5gpldi	472	43	viral	viral	JJ
cord-302047-vv5gpldi	472	44	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	472	45	dynamics	dynamic	NNS
cord-302047-vv5gpldi	472	46	.	.	.
cord-302047-vv5gpldi	473	1	We	-PRON-	PRP
cord-302047-vv5gpldi	473	2	have	have	VBP
cord-302047-vv5gpldi	473	3	illustrated	illustrate	VBN
cord-302047-vv5gpldi	473	4	this	this	DT
cord-302047-vv5gpldi	473	5	idea	idea	NN
cord-302047-vv5gpldi	473	6	with	with	IN
cord-302047-vv5gpldi	473	7	a	a	DT
cord-302047-vv5gpldi	473	8	simple	simple	JJ
cord-302047-vv5gpldi	473	9	simulation	simulation	NN
cord-302047-vv5gpldi	473	10	model	model	NN
cord-302047-vv5gpldi	473	11	that	that	WDT
cord-302047-vv5gpldi	473	12	considers	consider	VBZ
cord-302047-vv5gpldi	473	13	the	the	DT
cord-302047-vv5gpldi	473	14	effect	effect	NN
cord-302047-vv5gpldi	473	15	of	of	IN
cord-302047-vv5gpldi	473	16	genetic	genetic	JJ
cord-302047-vv5gpldi	473	17	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	473	18	(	(	-LRB-
cord-302047-vv5gpldi	473	19	Box	Box	NNP
cord-302047-vv5gpldi	473	20	1	1	CD
cord-302047-vv5gpldi	473	21	)	)	-RRB-
cord-302047-vv5gpldi	473	22	,	,	,
cord-302047-vv5gpldi	473	23	where	where	WRB
cord-302047-vv5gpldi	473	24	the	the	DT
cord-302047-vv5gpldi	473	25	observed	observed	JJ
cord-302047-vv5gpldi	473	26	stability	stability	NN
cord-302047-vv5gpldi	473	27	of	of	IN
cord-302047-vv5gpldi	473	28	the	the	DT
cord-302047-vv5gpldi	473	29	viral	viral	JJ
cord-302047-vv5gpldi	473	30	genome	genome	NN
cord-302047-vv5gpldi	473	31	decreases	decrease	VBZ
cord-302047-vv5gpldi	473	32	as	as	IN
cord-302047-vv5gpldi	473	33	the	the	DT
cord-302047-vv5gpldi	473	34	bottleneck	bottleneck	NN
cord-302047-vv5gpldi	473	35	is	be	VBZ
cord-302047-vv5gpldi	473	36	widened	widen	VBN
cord-302047-vv5gpldi	473	37	.	.	.
cord-302047-vv5gpldi	474	1	The	the	DT
cord-302047-vv5gpldi	474	2	interplay	interplay	NN
cord-302047-vv5gpldi	474	3	between	between	IN
cord-302047-vv5gpldi	474	4	all	all	DT
cord-302047-vv5gpldi	474	5	factors	factor	NNS
cord-302047-vv5gpldi	474	6	affecting	affect	VBG
cord-302047-vv5gpldi	474	7	insert	insert	JJ
cord-302047-vv5gpldi	474	8	stability	stability	NN
cord-302047-vv5gpldi	474	9	appears	appear	VBZ
cord-302047-vv5gpldi	474	10	to	to	TO
cord-302047-vv5gpldi	474	11	be	be	VB
cord-302047-vv5gpldi	474	12	complex	complex	JJ
cord-302047-vv5gpldi	474	13	and	and	CC
cord-302047-vv5gpldi	474	14	unexpectedly	unexpectedly	RB
cord-302047-vv5gpldi	474	15	sensitive	sensitive	JJ
cord-302047-vv5gpldi	474	16	to	to	IN
cord-302047-vv5gpldi	474	17	the	the	DT
cord-302047-vv5gpldi	474	18	exact	exact	JJ
cord-302047-vv5gpldi	474	19	conditions	condition	NNS
cord-302047-vv5gpldi	474	20	under	under	IN
cord-302047-vv5gpldi	474	21	which	which	WDT
cord-302047-vv5gpldi	474	22	a	a	DT
cord-302047-vv5gpldi	474	23	virus	virus	NN
cord-302047-vv5gpldi	474	24	population	population	NN
cord-302047-vv5gpldi	474	25	evolves	evolve	VBZ
cord-302047-vv5gpldi	474	26	.	.	.
cord-302047-vv5gpldi	475	1	Given	give	VBN
cord-302047-vv5gpldi	475	2	these	these	DT
cord-302047-vv5gpldi	475	3	complexities	complexity	NNS
cord-302047-vv5gpldi	475	4	,	,	,
cord-302047-vv5gpldi	475	5	we	-PRON-	PRP
cord-302047-vv5gpldi	475	6	think	think	VBP
cord-302047-vv5gpldi	475	7	it	-PRON-	PRP
cord-302047-vv5gpldi	475	8	may	may	MD
cord-302047-vv5gpldi	475	9	be	be	VB
cord-302047-vv5gpldi	475	10	challenging	challenge	VBG
cord-302047-vv5gpldi	475	11	to	to	TO
cord-302047-vv5gpldi	475	12	develop	develop	VB
cord-302047-vv5gpldi	475	13	predictive	predictive	JJ
cord-302047-vv5gpldi	475	14	models	model	NNS
cord-302047-vv5gpldi	475	15	of	of	IN
cord-302047-vv5gpldi	475	16	insert	insert	JJ
cord-302047-vv5gpldi	475	17	stability	stability	NN
cord-302047-vv5gpldi	475	18	,	,	,
cord-302047-vv5gpldi	475	19	for	for	IN
cord-302047-vv5gpldi	475	20	different	different	JJ
cord-302047-vv5gpldi	475	21	types	type	NNS
cord-302047-vv5gpldi	475	22	of	of	IN
cord-302047-vv5gpldi	475	23	virus	virus	NN
cord-302047-vv5gpldi	475	24	genomes	genome	NNS
cord-302047-vv5gpldi	475	25	under	under	IN
cord-302047-vv5gpldi	475	26	different	different	JJ
cord-302047-vv5gpldi	475	27	conditions	condition	NNS
cord-302047-vv5gpldi	475	28	.	.	.
cord-302047-vv5gpldi	476	1	We	-PRON-	PRP
cord-302047-vv5gpldi	476	2	hope	hope	VBP
cord-302047-vv5gpldi	476	3	to	to	TO
cord-302047-vv5gpldi	476	4	see	see	VB
cord-302047-vv5gpldi	476	5	developments	development	NNS
cord-302047-vv5gpldi	476	6	in	in	IN
cord-302047-vv5gpldi	476	7	this	this	DT
cord-302047-vv5gpldi	476	8	area	area	NN
cord-302047-vv5gpldi	476	9	,	,	,
cord-302047-vv5gpldi	476	10	possibly	possibly	RB
cord-302047-vv5gpldi	476	11	linked	link	VBN
cord-302047-vv5gpldi	476	12	to	to	IN
cord-302047-vv5gpldi	476	13	resurging	resurge	VBG
cord-302047-vv5gpldi	476	14	interest	interest	NN
cord-302047-vv5gpldi	476	15	in	in	IN
cord-302047-vv5gpldi	476	16	preventing	prevent	VBG
cord-302047-vv5gpldi	476	17	and	and	CC
cord-302047-vv5gpldi	476	18	exploiting	exploit	VBG
cord-302047-vv5gpldi	476	19	DI	DI	NNP
cord-302047-vv5gpldi	476	20	viruses	virus	NNS
cord-302047-vv5gpldi	476	21	.	.	.
cord-302047-vv5gpldi	477	1	However	however	RB
cord-302047-vv5gpldi	477	2	,	,	,
cord-302047-vv5gpldi	477	3	we	-PRON-	PRP
cord-302047-vv5gpldi	477	4	think	think	VBP
cord-302047-vv5gpldi	477	5	that	that	IN
cord-302047-vv5gpldi	477	6	experimental	experimental	JJ
cord-302047-vv5gpldi	477	7	tests	test	NNS
cord-302047-vv5gpldi	477	8	of	of	IN
cord-302047-vv5gpldi	477	9	the	the	DT
cord-302047-vv5gpldi	477	10	stability	stability	NN
cord-302047-vv5gpldi	477	11	of	of	IN
cord-302047-vv5gpldi	477	12	viral	viral	JJ
cord-302047-vv5gpldi	477	13	constructs	construct	NNS
cord-302047-vv5gpldi	477	14	will	will	MD
cord-302047-vv5gpldi	477	15	remain	remain	VB
cord-302047-vv5gpldi	477	16	important	important	JJ
cord-302047-vv5gpldi	477	17	in	in	IN
cord-302047-vv5gpldi	477	18	the	the	DT
cord-302047-vv5gpldi	477	19	foreseeable	foreseeable	JJ
cord-302047-vv5gpldi	477	20	future	future	NN
cord-302047-vv5gpldi	477	21	.	.	.
cord-302047-vv5gpldi	478	1	Experimental	experimental	JJ
cord-302047-vv5gpldi	478	2	evolution	evolution	NN
cord-302047-vv5gpldi	478	3	can	can	MD
cord-302047-vv5gpldi	478	4	detect	detect	VB
cord-302047-vv5gpldi	478	5	design	design	NN
cord-302047-vv5gpldi	478	6	problems	problem	NNS
cord-302047-vv5gpldi	478	7	in	in	IN
cord-302047-vv5gpldi	478	8	engineered	engineer	VBN
cord-302047-vv5gpldi	478	9	genomes	genome	NNS
cord-302047-vv5gpldi	478	10	by	by	IN
cord-302047-vv5gpldi	478	11	looking	look	VBG
cord-302047-vv5gpldi	478	12	at	at	IN
cord-302047-vv5gpldi	478	13	fitness	fitness	NN
cord-302047-vv5gpldi	478	14	and	and	CC
cord-302047-vv5gpldi	478	15	evolutionary	evolutionary	JJ
cord-302047-vv5gpldi	478	16	stability	stability	NN
cord-302047-vv5gpldi	478	17	(	(	-LRB-
cord-302047-vv5gpldi	478	18	Springman	Springman	NNP
cord-302047-vv5gpldi	478	19	et	et	NNP
cord-302047-vv5gpldi	478	20	al	al	NNP
cord-302047-vv5gpldi	478	21	.	.	.
cord-302047-vv5gpldi	478	22	)	)	-RRB-
cord-302047-vv5gpldi	478	23	.	.	.
cord-302047-vv5gpldi	479	1	As	as	IN
cord-302047-vv5gpldi	479	2	Springman	Springman	NNP
cord-302047-vv5gpldi	479	3	and	and	CC
cord-302047-vv5gpldi	479	4	collaborators	collaborator	NNS
cord-302047-vv5gpldi	479	5	suggest	suggest	VBP
cord-302047-vv5gpldi	479	6	,	,	,
cord-302047-vv5gpldi	479	7	experimental	experimental	JJ
cord-302047-vv5gpldi	479	8	evolution	evolution	NN
cord-302047-vv5gpldi	479	9	may	may	MD
cord-302047-vv5gpldi	479	10	also	also	RB
cord-302047-vv5gpldi	479	11	prove	prove	VB
cord-302047-vv5gpldi	479	12	useful	useful	JJ
cord-302047-vv5gpldi	479	13	for	for	IN
cord-302047-vv5gpldi	479	14	optimizing	optimize	VBG
cord-302047-vv5gpldi	479	15	the	the	DT
cord-302047-vv5gpldi	479	16	stability	stability	NN
cord-302047-vv5gpldi	479	17	of	of	IN
cord-302047-vv5gpldi	479	18	expression	expression	NN
cord-302047-vv5gpldi	479	19	vectors	vector	NNS
cord-302047-vv5gpldi	479	20	by	by	IN
cord-302047-vv5gpldi	479	21	ameliorating	ameliorate	VBG
cord-302047-vv5gpldi	479	22	constraints	constraint	NNS
cord-302047-vv5gpldi	479	23	for	for	IN
cord-302047-vv5gpldi	479	24	which	which	WDT
cord-302047-vv5gpldi	479	25	solutions	solution	NNS
cord-302047-vv5gpldi	479	26	are	be	VBP
cord-302047-vv5gpldi	479	27	hard	hard	JJ
cord-302047-vv5gpldi	479	28	to	to	TO
cord-302047-vv5gpldi	479	29	predict	predict	VB
cord-302047-vv5gpldi	479	30	because	because	IN
cord-302047-vv5gpldi	479	31	we	-PRON-	PRP
cord-302047-vv5gpldi	479	32	lack	lack	VBP
cord-302047-vv5gpldi	479	33	a	a	DT
cord-302047-vv5gpldi	479	34	mechanistic	mechanistic	JJ
cord-302047-vv5gpldi	479	35	understanding	understanding	NN
cord-302047-vv5gpldi	479	36	,	,	,
cord-302047-vv5gpldi	479	37	such	such	JJ
cord-302047-vv5gpldi	479	38	as	as	IN
cord-302047-vv5gpldi	479	39	codon	codon	NN
cord-302047-vv5gpldi	479	40	usage	usage	NN
cord-302047-vv5gpldi	479	41	(	(	-LRB-
cord-302047-vv5gpldi	479	42	Carrasco	Carrasco	NNP
cord-302047-vv5gpldi	479	43	,	,	,
cord-302047-vv5gpldi	479	44	de	de	FW
cord-302047-vv5gpldi	479	45	la	la	FW
cord-302047-vv5gpldi	479	46	Iglesia	Iglesia	NNP
cord-302047-vv5gpldi	479	47	,	,	,
cord-302047-vv5gpldi	479	48	and	and	CC
cord-302047-vv5gpldi	479	49	Elena	Elena	NNP
cord-302047-vv5gpldi	479	50	2007	2007	CD
cord-302047-vv5gpldi	479	51	;	;	:
cord-302047-vv5gpldi	479	52	Agashe	Agashe	NNP
cord-302047-vv5gpldi	479	53	et	et	NNP
cord-302047-vv5gpldi	479	54	al	al	NNP
cord-302047-vv5gpldi	479	55	.	.	NNP
cord-302047-vv5gpldi	479	56	2013	2013	CD
cord-302047-vv5gpldi	479	57	)	)	-RRB-
cord-302047-vv5gpldi	479	58	.	.	.
cord-302047-vv5gpldi	480	1	This	this	DT
cord-302047-vv5gpldi	480	2	approach	approach	NN
cord-302047-vv5gpldi	480	3	can	can	MD
cord-302047-vv5gpldi	480	4	lead	lead	VB
cord-302047-vv5gpldi	480	5	to	to	IN
cord-302047-vv5gpldi	480	6	improved	improve	VBN
cord-302047-vv5gpldi	480	7	engineering	engineering	NN
cord-302047-vv5gpldi	480	8	of	of	IN
cord-302047-vv5gpldi	480	9	viral	viral	JJ
cord-302047-vv5gpldi	480	10	genomes	genome	NNS
cord-302047-vv5gpldi	480	11	,	,	,
cord-302047-vv5gpldi	480	12	which	which	WDT
cord-302047-vv5gpldi	480	13	is	be	VBZ
cord-302047-vv5gpldi	480	14	also	also	RB
cord-302047-vv5gpldi	480	15	of	of	IN
cord-302047-vv5gpldi	480	16	interest	interest	NN
cord-302047-vv5gpldi	480	17	for	for	IN
cord-302047-vv5gpldi	480	18	designing	design	VBG
cord-302047-vv5gpldi	480	19	vectors	vector	NNS
cord-302047-vv5gpldi	480	20	with	with	IN
cord-302047-vv5gpldi	480	21	tags	tag	NNS
cord-302047-vv5gpldi	480	22	to	to	TO
cord-302047-vv5gpldi	480	23	follow	follow	VB
cord-302047-vv5gpldi	480	24	viral	viral	JJ
cord-302047-vv5gpldi	480	25	infection	infection	NN
cord-302047-vv5gpldi	480	26	,	,	,
cord-302047-vv5gpldi	480	27	and	and	CC
cord-302047-vv5gpldi	480	28	for	for	IN
cord-302047-vv5gpldi	480	29	the	the	DT
cord-302047-vv5gpldi	480	30	use	use	NN
cord-302047-vv5gpldi	480	31	of	of	IN
cord-302047-vv5gpldi	480	32	viral	viral	JJ
cord-302047-vv5gpldi	480	33	vectors	vector	NNS
cord-302047-vv5gpldi	480	34	for	for	IN
cord-302047-vv5gpldi	480	35	gene	gene	NN
cord-302047-vv5gpldi	480	36	therapy	therapy	NN
cord-302047-vv5gpldi	480	37	as	as	RB
cord-302047-vv5gpldi	480	38	well	well	RB
cord-302047-vv5gpldi	480	39	as	as	IN
cord-302047-vv5gpldi	480	40	for	for	IN
cord-302047-vv5gpldi	480	41	vaccine	vaccine	NN
cord-302047-vv5gpldi	480	42	vectors	vector	NNS
cord-302047-vv5gpldi	480	43	.	.	.
cord-302047-vv5gpldi	481	1	Finally	finally	RB
cord-302047-vv5gpldi	481	2	,	,	,
cord-302047-vv5gpldi	481	3	for	for	IN
cord-302047-vv5gpldi	481	4	real	real	JJ
cord-302047-vv5gpldi	481	5	-	-	HYPH
cord-302047-vv5gpldi	481	6	world	world	NN
cord-302047-vv5gpldi	481	7	applications	application	NNS
cord-302047-vv5gpldi	481	8	it	-PRON-	PRP
cord-302047-vv5gpldi	481	9	can	can	MD
cord-302047-vv5gpldi	481	10	be	be	VB
cord-302047-vv5gpldi	481	11	useful	useful	JJ
cord-302047-vv5gpldi	481	12	to	to	TO
cord-302047-vv5gpldi	481	13	determine	determine	VB
cord-302047-vv5gpldi	481	14	quantitatively	quantitatively	RB
cord-302047-vv5gpldi	481	15	the	the	DT
cord-302047-vv5gpldi	481	16	impact	impact	NN
cord-302047-vv5gpldi	481	17	of	of	IN
cord-302047-vv5gpldi	481	18	the	the	DT
cord-302047-vv5gpldi	481	19	loss	loss	NN
cord-302047-vv5gpldi	481	20	of	of	IN
cord-302047-vv5gpldi	481	21	inserted	insert	VBN
cord-302047-vv5gpldi	481	22	sequences	sequence	NNS
cord-302047-vv5gpldi	481	23	on	on	IN
cord-302047-vv5gpldi	481	24	the	the	DT
cord-302047-vv5gpldi	481	25	desired	desire	VBN
cord-302047-vv5gpldi	481	26	output	output	NN
cord-302047-vv5gpldi	481	27	.	.	.
cord-302047-vv5gpldi	482	1	For	for	IN
cord-302047-vv5gpldi	482	2	example	example	NN
cord-302047-vv5gpldi	482	3	,	,	,
cord-302047-vv5gpldi	482	4	models	model	NNS
cord-302047-vv5gpldi	482	5	suggest	suggest	VBP
cord-302047-vv5gpldi	482	6	that	that	IN
cord-302047-vv5gpldi	482	7	deletions	deletion	NNS
cord-302047-vv5gpldi	482	8	in	in	IN
cord-302047-vv5gpldi	482	9	vector	vector	NN
cord-302047-vv5gpldi	482	10	vaccines	vaccine	NNS
cord-302047-vv5gpldi	482	11	may	may	MD
cord-302047-vv5gpldi	482	12	not	not	RB
cord-302047-vv5gpldi	482	13	have	have	VB
cord-302047-vv5gpldi	482	14	a	a	DT
cord-302047-vv5gpldi	482	15	large	large	JJ
cord-302047-vv5gpldi	482	16	impact	impact	NN
cord-302047-vv5gpldi	482	17	on	on	IN
cord-302047-vv5gpldi	482	18	eliciting	elicit	VBG
cord-302047-vv5gpldi	482	19	the	the	DT
cord-302047-vv5gpldi	482	20	desired	desire	VBN
cord-302047-vv5gpldi	482	21	immune	immune	JJ
cord-302047-vv5gpldi	482	22	response	response	NN
cord-302047-vv5gpldi	482	23	(	(	-LRB-
cord-302047-vv5gpldi	482	24	Bull	Bull	NNP
cord-302047-vv5gpldi	482	25	,	,	,
cord-302047-vv5gpldi	482	26	Nuismer	Nuismer	NNP
cord-302047-vv5gpldi	482	27	,	,	,
cord-302047-vv5gpldi	482	28	and	and	CC
cord-302047-vv5gpldi	482	29	Antia	Antia	NNP
cord-302047-vv5gpldi	482	30	2019	2019	CD
cord-302047-vv5gpldi	482	31	)	)	-RRB-
cord-302047-vv5gpldi	482	32	.	.	.
cord-302047-vv5gpldi	483	1	We	-PRON-	PRP
cord-302047-vv5gpldi	483	2	have	have	VBP
cord-302047-vv5gpldi	483	3	noticed	notice	VBN
cord-302047-vv5gpldi	483	4	that	that	IN
cord-302047-vv5gpldi	483	5	a	a	DT
cord-302047-vv5gpldi	483	6	surprisingly	surprisingly	RB
cord-302047-vv5gpldi	483	7	large	large	JJ
cord-302047-vv5gpldi	483	8	number	number	NN
cord-302047-vv5gpldi	483	9	of	of	IN
cord-302047-vv5gpldi	483	10	studies	study	NNS
cord-302047-vv5gpldi	483	11	draw	draw	VBP
cord-302047-vv5gpldi	483	12	conclusions	conclusion	NNS
cord-302047-vv5gpldi	483	13	on	on	IN
cord-302047-vv5gpldi	483	14	the	the	DT
cord-302047-vv5gpldi	483	15	stability	stability	NN
cord-302047-vv5gpldi	483	16	of	of	IN
cord-302047-vv5gpldi	483	17	inserted	insert	VBN
cord-302047-vv5gpldi	483	18	sequences	sequence	NNS
cord-302047-vv5gpldi	483	19	in	in	IN
cord-302047-vv5gpldi	483	20	viral	viral	JJ
cord-302047-vv5gpldi	483	21	genomes	genome	NNS
cord-302047-vv5gpldi	483	22	based	base	VBN
cord-302047-vv5gpldi	483	23	on	on	IN
cord-302047-vv5gpldi	483	24	experiments	experiment	NNS
cord-302047-vv5gpldi	483	25	with	with	IN
cord-302047-vv5gpldi	483	26	either	either	CC
cord-302047-vv5gpldi	483	27	no	no	DT
cord-302047-vv5gpldi	483	28	or	or	CC
cord-302047-vv5gpldi	483	29	low	low	JJ
cord-302047-vv5gpldi	483	30	replication	replication	NN
cord-302047-vv5gpldi	483	31	.	.	.
cord-302047-vv5gpldi	484	1	We	-PRON-	PRP
cord-302047-vv5gpldi	484	2	can	can	MD
cord-302047-vv5gpldi	484	3	not	not	RB
cord-302047-vv5gpldi	484	4	stress	stress	VB
cord-302047-vv5gpldi	484	5	enough	enough	RB
cord-302047-vv5gpldi	484	6	the	the	DT
cord-302047-vv5gpldi	484	7	importance	importance	NN
cord-302047-vv5gpldi	484	8	of	of	IN
cord-302047-vv5gpldi	484	9	replication	replication	NN
cord-302047-vv5gpldi	484	10	in	in	IN
cord-302047-vv5gpldi	484	11	studying	study	VBG
cord-302047-vv5gpldi	484	12	genomic	genomic	JJ
cord-302047-vv5gpldi	484	13	stability	stability	NN
cord-302047-vv5gpldi	484	14	,	,	,
cord-302047-vv5gpldi	484	15	in	in	IN
cord-302047-vv5gpldi	484	16	the	the	DT
cord-302047-vv5gpldi	484	17	first	first	JJ
cord-302047-vv5gpldi	484	18	place	place	NN
cord-302047-vv5gpldi	484	19	because	because	IN
cord-302047-vv5gpldi	484	20	mutation	mutation	NN
cord-302047-vv5gpldi	484	21	is	be	VBZ
cord-302047-vv5gpldi	484	22	a	a	DT
cord-302047-vv5gpldi	484	23	stochastic	stochastic	JJ
cord-302047-vv5gpldi	484	24	process	process	NN
cord-302047-vv5gpldi	484	25	.	.	.
cord-302047-vv5gpldi	485	1	Moreover	moreover	RB
cord-302047-vv5gpldi	485	2	,	,	,
cord-302047-vv5gpldi	485	3	as	as	IN
cord-302047-vv5gpldi	485	4	illustrated	illustrate	VBN
cord-302047-vv5gpldi	485	5	by	by	IN
cord-302047-vv5gpldi	485	6	our	-PRON-	PRP$
cord-302047-vv5gpldi	485	7	simple	simple	JJ
cord-302047-vv5gpldi	485	8	simulations	simulation	NNS
cord-302047-vv5gpldi	485	9	-	-	:
cord-302047-vv5gpldi	485	10	in	in	IN
cord-302047-vv5gpldi	485	11	which	which	WDT
cord-302047-vv5gpldi	485	12	mutation	mutation	NN
cord-302047-vv5gpldi	485	13	is	be	VBZ
cord-302047-vv5gpldi	485	14	deterministic	deterministic	JJ
cord-302047-vv5gpldi	485	15	-	-	HYPH
cord-302047-vv5gpldi	485	16	bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	485	17	and	and	CC
cord-302047-vv5gpldi	485	18	population	population	NN
cord-302047-vv5gpldi	485	19	dynamics	dynamic	NNS
cord-302047-vv5gpldi	485	20	can	can	MD
cord-302047-vv5gpldi	485	21	also	also	RB
cord-302047-vv5gpldi	485	22	introduce	introduce	VB
cord-302047-vv5gpldi	485	23	further	further	JJ
cord-302047-vv5gpldi	485	24	stochastic	stochastic	JJ
cord-302047-vv5gpldi	485	25	effects	effect	NNS
cord-302047-vv5gpldi	485	26	that	that	WDT
cord-302047-vv5gpldi	485	27	influence	influence	VBP
cord-302047-vv5gpldi	485	28	stability	stability	NN
cord-302047-vv5gpldi	485	29	(	(	-LRB-
cord-302047-vv5gpldi	485	30	Fig	fig	NN
cord-302047-vv5gpldi	485	31	.	.	.
cord-302047-vv5gpldi	485	32	1	1	CD
cord-302047-vv5gpldi	485	33	)	)	-RRB-
cord-302047-vv5gpldi	485	34	.	.	.
cord-302047-vv5gpldi	486	1	Furthermore	furthermore	RB
cord-302047-vv5gpldi	486	2	,	,	,
cord-302047-vv5gpldi	486	3	empirical	empirical	JJ
cord-302047-vv5gpldi	486	4	studies	study	NNS
cord-302047-vv5gpldi	486	5	with	with	IN
cord-302047-vv5gpldi	486	6	high	high	JJ
cord-302047-vv5gpldi	486	7	levels	level	NNS
cord-302047-vv5gpldi	486	8	of	of	IN
cord-302047-vv5gpldi	486	9	replication	replication	NN
cord-302047-vv5gpldi	486	10	show	show	VBP
cord-302047-vv5gpldi	486	11	the	the	DT
cord-302047-vv5gpldi	486	12	extent	extent	NN
cord-302047-vv5gpldi	486	13	to	to	TO
cord-302047-vv5gpldi	486	14	which	which	WDT
cord-302047-vv5gpldi	486	15	observed	observe	VBD
cord-302047-vv5gpldi	486	16	stability	stability	NN
cord-302047-vv5gpldi	486	17	does	do	VBZ
cord-302047-vv5gpldi	486	18	vary	vary	VB
cord-302047-vv5gpldi	486	19	between	between	IN
cord-302047-vv5gpldi	486	20	replicates	replicate	NNS
cord-302047-vv5gpldi	486	21	(	(	-LRB-
cord-302047-vv5gpldi	486	22	Zwart	Zwart	NNP
cord-302047-vv5gpldi	486	23	et	et	FW
cord-302047-vv5gpldi	486	24	al	al	NNP
cord-302047-vv5gpldi	486	25	.	.	NNP
cord-302047-vv5gpldi	486	26	2014	2014	CD
cord-302047-vv5gpldi	486	27	)	)	-RRB-
cord-302047-vv5gpldi	486	28	.	.	.
cord-302047-vv5gpldi	487	1	Good	Good	NNP
cord-302047-vv5gpldi	487	2	Codons	Codons	NNPS
cord-302047-vv5gpldi	487	3	,	,	,
cord-302047-vv5gpldi	487	4	Bad	Bad	NNP
cord-302047-vv5gpldi	487	5	Transcript	Transcript	NNP
cord-302047-vv5gpldi	487	6	:	:	:
cord-302047-vv5gpldi	487	7	Large	large	JJ
cord-302047-vv5gpldi	487	8	Reductions	reduction	NNS
cord-302047-vv5gpldi	487	9	in	in	IN
cord-302047-vv5gpldi	487	10	Gene	Gene	NNP
cord-302047-vv5gpldi	487	11	Expression	Expression	NNP
cord-302047-vv5gpldi	487	12	and	and	CC
cord-302047-vv5gpldi	487	13	Fitness	Fitness	NNP
cord-302047-vv5gpldi	487	14	Arising	Arising	NNP
cord-302047-vv5gpldi	487	15	from	from	IN
cord-302047-vv5gpldi	487	16	Synonymous	Synonymous	NNP
cord-302047-vv5gpldi	487	17	Mutations	Mutations	NNPS
cord-302047-vv5gpldi	487	18	in	in	IN
cord-302047-vv5gpldi	487	19	a	a	DT
cord-302047-vv5gpldi	487	20	Key	Key	NNP
cord-302047-vv5gpldi	487	21	Enzyme	Enzyme	NNP
cord-302047-vv5gpldi	487	22	Inhibition	Inhibition	NNP
cord-302047-vv5gpldi	487	23	of	of	IN
cord-302047-vv5gpldi	487	24	Human	Human	NNP
cord-302047-vv5gpldi	487	25	Immunodeficiency	Immunodeficiency	NNP
cord-302047-vv5gpldi	487	26	Virus	Virus	NNP
cord-302047-vv5gpldi	487	27	Type	Type	NNP
cord-302047-vv5gpldi	487	28	1	1	CD
cord-302047-vv5gpldi	488	1	(	(	-LRB-
cord-302047-vv5gpldi	488	2	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	488	3	)	)	-RRB-
cord-302047-vv5gpldi	488	4	Replication	Replication	NNP
cord-302047-vv5gpldi	488	5	by	by	IN
cord-302047-vv5gpldi	488	6	a	a	DT
cord-302047-vv5gpldi	488	7	Two	two	CD
cord-302047-vv5gpldi	488	8	-	-	HYPH
cord-302047-vv5gpldi	488	9	amino	amino	NN
cord-302047-vv5gpldi	488	10	-	-	HYPH
cord-302047-vv5gpldi	488	11	acid	acid	JJ
cord-302047-vv5gpldi	488	12	Insertion	insertion	NN
cord-302047-vv5gpldi	488	13	in	in	IN
cord-302047-vv5gpldi	488	14	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	488	15	Vif	Vif	NNP
cord-302047-vv5gpldi	488	16	from	from	IN
cord-302047-vv5gpldi	488	17	a	a	DT
cord-302047-vv5gpldi	488	18	Nonprogressing	Nonprogressing	NNP
cord-302047-vv5gpldi	488	19	Mother	Mother	NNP
cord-302047-vv5gpldi	488	20	and	and	CC
cord-302047-vv5gpldi	488	21	Child	Child	NNP
cord-302047-vv5gpldi	488	22	Poxviral	Poxviral	NNP
cord-302047-vv5gpldi	488	23	Promoters	Promoters	NNPS
cord-302047-vv5gpldi	488	24	for	for	IN
cord-302047-vv5gpldi	488	25	Improving	improve	VBG
cord-302047-vv5gpldi	488	26	the	the	DT
cord-302047-vv5gpldi	488	27	Immunogenicity	Immunogenicity	NNP
cord-302047-vv5gpldi	488	28	of	of	IN
cord-302047-vv5gpldi	488	29	MVA	MVA	NNP
cord-302047-vv5gpldi	488	30	Delivered	deliver	VBD
cord-302047-vv5gpldi	488	31	Vaccines	Vaccines	NNPS
cord-302047-vv5gpldi	488	32	Evidence	evidence	NN
cord-302047-vv5gpldi	488	33	That	that	IN
cord-302047-vv5gpldi	488	34	Gene	Gene	NNP
cord-302047-vv5gpldi	488	35	Amplification	Amplification	NNP
cord-302047-vv5gpldi	488	36	Underlies	underlie	VBZ
cord-302047-vv5gpldi	488	37	Adaptive	adaptive	JJ
cord-302047-vv5gpldi	488	38	Mutability	mutability	NN
cord-302047-vv5gpldi	488	39	of	of	IN
cord-302047-vv5gpldi	488	40	the	the	DT
cord-302047-vv5gpldi	488	41	Bacterial	Bacterial	NNP
cord-302047-vv5gpldi	488	42	Lac	Lac	NNP
cord-302047-vv5gpldi	488	43	Operon	Operon	NNP
cord-302047-vv5gpldi	488	44	Increased	increase	VBD
cord-302047-vv5gpldi	488	45	Replication	replication	NN
cord-302047-vv5gpldi	488	46	Capacity	capacity	NN
cord-302047-vv5gpldi	489	1	Following	follow	VBG
cord-302047-vv5gpldi	489	2	Evolution	evolution	NN
cord-302047-vv5gpldi	489	3	of	of	IN
cord-302047-vv5gpldi	489	4	PYxE	pyxe	JJ
cord-302047-vv5gpldi	489	5	Insertion	insertion	NN
cord-302047-vv5gpldi	489	6	in	in	IN
cord-302047-vv5gpldi	489	7	Gag	gag	NN
cord-302047-vv5gpldi	489	8	-	-	HYPH
cord-302047-vv5gpldi	489	9	p6	p6	NN
cord-302047-vv5gpldi	489	10	is	be	VBZ
cord-302047-vv5gpldi	489	11	Associated	associate	VBN
cord-302047-vv5gpldi	489	12	with	with	IN
cord-302047-vv5gpldi	489	13	Enhanced	Enhanced	NNP
cord-302047-vv5gpldi	489	14	Virulence	Virulence	NNP
cord-302047-vv5gpldi	489	15	in	in	IN
cord-302047-vv5gpldi	489	16	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	489	17	Subtype	Subtype	NNP
cord-302047-vv5gpldi	489	18	C	C	NNP
cord-302047-vv5gpldi	489	19	from	from	IN
cord-302047-vv5gpldi	489	20	East	East	NNP
cord-302047-vv5gpldi	489	21	Africa	Africa	NNP
cord-302047-vv5gpldi	489	22	Bovine	Bovine	NNP
cord-302047-vv5gpldi	489	23	Adenovirus-3	Adenovirus-3	NNP
cord-302047-vv5gpldi	489	24	as	as	IN
cord-302047-vv5gpldi	489	25	a	a	DT
cord-302047-vv5gpldi	489	26	Vaccine	Vaccine	NNP
cord-302047-vv5gpldi	489	27	Delivery	Delivery	NNP
cord-302047-vv5gpldi	489	28	Vehicle	Vehicle	NNP
cord-302047-vv5gpldi	489	29	VSV	VSV	NNP
cord-302047-vv5gpldi	489	30	-	-	HYPH
cord-302047-vv5gpldi	489	31	tumor	tumor	NN
cord-302047-vv5gpldi	489	32	Selective	selective	JJ
cord-302047-vv5gpldi	489	33	Replication	Replication	NNP
cord-302047-vv5gpldi	489	34	and	and	CC
cord-302047-vv5gpldi	489	35	Protein	Protein	NNP
cord-302047-vv5gpldi	489	36	Translation	Translation	NNP
cord-302047-vv5gpldi	490	1	The	the	DT
cord-302047-vv5gpldi	490	2	Evolution	Evolution	NNP
cord-302047-vv5gpldi	490	3	of	of	IN
cord-302047-vv5gpldi	490	4	Genome	Genome	NNP
cord-302047-vv5gpldi	490	5	Compression	Compression	NNP
cord-302047-vv5gpldi	490	6	and	and	CC
cord-302047-vv5gpldi	490	7	Genomic	Genomic	NNP
cord-302047-vv5gpldi	490	8	Novelty	Novelty	NNP
cord-302047-vv5gpldi	490	9	in	in	IN
cord-302047-vv5gpldi	490	10	RNA	RNA	NNP
cord-302047-vv5gpldi	490	11	Viruses	Viruses	NNPS
cord-302047-vv5gpldi	490	12	Reverse	reverse	VBP
cord-302047-vv5gpldi	490	13	Genetics	Genetics	NNPS
cord-302047-vv5gpldi	490	14	of	of	IN
cord-302047-vv5gpldi	490	15	Measles	Measles	NNP
cord-302047-vv5gpldi	490	16	Virus	Virus	NNP
cord-302047-vv5gpldi	490	17	and	and	CC
cord-302047-vv5gpldi	490	18	Resulting	result	VBG
cord-302047-vv5gpldi	490	19	Multivalent	Multivalent	NNP
cord-302047-vv5gpldi	491	1	Recombinant	recombinant	JJ
cord-302047-vv5gpldi	491	2	Vaccines	vaccine	NNS
cord-302047-vv5gpldi	491	3	:	:	:
cord-302047-vv5gpldi	491	4	Applications	application	NNS
cord-302047-vv5gpldi	491	5	of	of	IN
cord-302047-vv5gpldi	491	6	Recombinant	recombinant	JJ
cord-302047-vv5gpldi	491	7	Measles	Measles	NNP
cord-302047-vv5gpldi	491	8	Viruses	Viruses	NNPS
cord-302047-vv5gpldi	492	1	(	(	-LRB-
cord-302047-vv5gpldi	492	2	Non)parallel	Non)parallel	NNP
cord-302047-vv5gpldi	492	3	Evolution	Evolution	NNP
cord-302047-vv5gpldi	492	4	Genome	Genome	NNP
cord-302047-vv5gpldi	492	5	Packaging	Packaging	NNP
cord-302047-vv5gpldi	492	6	in	in	IN
cord-302047-vv5gpldi	492	7	Multi	multi	JJ
cord-302047-vv5gpldi	492	8	-	-	JJ
cord-302047-vv5gpldi	492	9	segmented	segmented	JJ
cord-302047-vv5gpldi	492	10	dsRNA	dsrna	NN
cord-302047-vv5gpldi	492	11	Viruses	virus	NNS
cord-302047-vv5gpldi	492	12	:	:	:
cord-302047-vv5gpldi	493	1	Distinct	Distinct	NNP
cord-302047-vv5gpldi	493	2	Mechanisms	Mechanisms	NNPS
cord-302047-vv5gpldi	493	3	with	with	IN
cord-302047-vv5gpldi	493	4	Similar	Similar	NNP
cord-302047-vv5gpldi	493	5	Outcomes	Outcomes	NNPS
cord-302047-vv5gpldi	493	6	'	'	POS
cord-302047-vv5gpldi	493	7	,	,	,
cord-302047-vv5gpldi	493	8	Current	Current	NNP
cord-302047-vv5gpldi	493	9	Opinion	Opinion	NNP
cord-302047-vv5gpldi	493	10	in	in	IN
cord-302047-vv5gpldi	493	11	Virology	Virology	NNP
cord-302047-vv5gpldi	493	12	Expression	Expression	NNP
cord-302047-vv5gpldi	493	13	of	of	IN
cord-302047-vv5gpldi	493	14	a	a	DT
cord-302047-vv5gpldi	493	15	Bacterial	Bacterial	NNP
cord-302047-vv5gpldi	493	16	Gene	Gene	NNP
cord-302047-vv5gpldi	493	17	in	in	IN
cord-302047-vv5gpldi	493	18	Plants	plant	NNS
cord-302047-vv5gpldi	493	19	by	by	IN
cord-302047-vv5gpldi	493	20	Using	use	VBG
cord-302047-vv5gpldi	493	21	a	a	DT
cord-302047-vv5gpldi	493	22	Viral	Viral	NNP
cord-302047-vv5gpldi	493	23	Vector	Vector	NNP
cord-302047-vv5gpldi	493	24	Nonsegmented	Nonsegmented	NNP
cord-302047-vv5gpldi	493	25	Negative	negative	JJ
cord-302047-vv5gpldi	493	26	-	-	HYPH
cord-302047-vv5gpldi	493	27	strand	strand	NN
cord-302047-vv5gpldi	493	28	Viruses	virus	NNS
cord-302047-vv5gpldi	493	29	as	as	IN
cord-302047-vv5gpldi	493	30	Vaccine	vaccine	NN
cord-302047-vv5gpldi	493	31	Vectors	Vectors	NNP
cord-302047-vv5gpldi	493	32	Recombinant	Recombinant	NNP
cord-302047-vv5gpldi	493	33	Vector	Vector	NNP
cord-302047-vv5gpldi	493	34	Vaccine	Vaccine	NNP
cord-302047-vv5gpldi	493	35	Evolution	Evolution	NNP
cord-302047-vv5gpldi	493	36	Protein	Protein	NNP
cord-302047-vv5gpldi	493	37	Tagging	Tagging	NNP
cord-302047-vv5gpldi	493	38	and	and	CC
cord-302047-vv5gpldi	493	39	Detection	Detection	NNP
cord-302047-vv5gpldi	493	40	with	with	IN
cord-302047-vv5gpldi	493	41	Engineered	Engineered	NNP
cord-302047-vv5gpldi	493	42	Self	Self	NNP
cord-302047-vv5gpldi	493	43	-	-	HYPH
cord-302047-vv5gpldi	493	44	assembling	assemble	VBG
cord-302047-vv5gpldi	493	45	Fragments	fragment	NNS
cord-302047-vv5gpldi	493	46	of	of	IN
cord-302047-vv5gpldi	493	47	Green	Green	NNP
cord-302047-vv5gpldi	493	48	Fluorescent	Fluorescent	NNP
cord-302047-vv5gpldi	493	49	Protein	Protein	NNP
cord-302047-vv5gpldi	493	50	Distribution	Distribution	NNP
cord-302047-vv5gpldi	493	51	of	of	IN
cord-302047-vv5gpldi	493	52	Fitness	Fitness	NNP
cord-302047-vv5gpldi	493	53	and	and	CC
cord-302047-vv5gpldi	493	54	Virulence	Virulence	NNP
cord-302047-vv5gpldi	493	55	Effects	effect	NNS
cord-302047-vv5gpldi	493	56	Caused	cause	VBN
cord-302047-vv5gpldi	493	57	by	by	IN
cord-302047-vv5gpldi	493	58	Single	single	JJ
cord-302047-vv5gpldi	493	59	-	-	HYPH
cord-302047-vv5gpldi	493	60	nucleotide	nucleotide	JJ
cord-302047-vv5gpldi	493	61	Substitutions	Substitutions	NNPS
cord-302047-vv5gpldi	493	62	in	in	IN
cord-302047-vv5gpldi	493	63	Tobacco	Tobacco	NNP
cord-302047-vv5gpldi	493	64	Etch	Etch	NNP
cord-302047-vv5gpldi	493	65	Virus	Virus	NNP
cord-302047-vv5gpldi	493	66	Overview	Overview	NNP
cord-302047-vv5gpldi	493	67	of	of	IN
cord-302047-vv5gpldi	493	68	the	the	DT
cord-302047-vv5gpldi	493	69	Baculovirus	Baculovirus	NNP
cord-302047-vv5gpldi	493	70	Expression	Expression	NNP
cord-302047-vv5gpldi	493	71	System	System	NNP
cord-302047-vv5gpldi	493	72	Fitness	Fitness	NNP
cord-302047-vv5gpldi	493	73	of	of	IN
cord-302047-vv5gpldi	493	74	RNA	RNA	NNP
cord-302047-vv5gpldi	493	75	Virus	Virus	NNP
cord-302047-vv5gpldi	493	76	Decreased	decrease	VBN
cord-302047-vv5gpldi	493	77	by	by	IN
cord-302047-vv5gpldi	493	78	Muller	Muller	NNP
cord-302047-vv5gpldi	493	79	's	's	POS
cord-302047-vv5gpldi	493	80	Ratchet	Ratchet	NNP
cord-302047-vv5gpldi	493	81	'	'	''
cord-302047-vv5gpldi	493	82	Potato	Potato	NNP
cord-302047-vv5gpldi	493	83	Virus	Virus	NNP
cord-302047-vv5gpldi	493	84	X	X	NNP
cord-302047-vv5gpldi	493	85	as	as	IN
cord-302047-vv5gpldi	493	86	a	a	DT
cord-302047-vv5gpldi	493	87	Vector	vector	NN
cord-302047-vv5gpldi	493	88	for	for	IN
cord-302047-vv5gpldi	493	89	Gene	Gene	NNP
cord-302047-vv5gpldi	493	90	Expression	Expression	NNP
cord-302047-vv5gpldi	493	91	in	in	IN
cord-302047-vv5gpldi	493	92	Plants	Plants	NNP
cord-302047-vv5gpldi	493	93	Bacteriophage	Bacteriophage	NNP
cord-302047-vv5gpldi	493	94	Lambda	Lambda	NNP
cord-302047-vv5gpldi	493	95	as	as	IN
cord-302047-vv5gpldi	493	96	a	a	DT
cord-302047-vv5gpldi	493	97	Cloning	clone	VBG
cord-302047-vv5gpldi	493	98	Vector	vector	NN
cord-302047-vv5gpldi	493	99	Stability	stability	NN
cord-302047-vv5gpldi	493	100	of	of	IN
cord-302047-vv5gpldi	493	101	Recombinant	recombinant	JJ
cord-302047-vv5gpldi	493	102	Plant	plant	NN
cord-302047-vv5gpldi	493	103	Viruses	virus	NNS
cord-302047-vv5gpldi	493	104	Containing	contain	VBG
cord-302047-vv5gpldi	493	105	Genes	Genes	NNPS
cord-302047-vv5gpldi	493	106	of	of	IN
cord-302047-vv5gpldi	493	107	Unrelated	unrelated	JJ
cord-302047-vv5gpldi	493	108	Plant	plant	NN
cord-302047-vv5gpldi	493	109	Viruses	virus	NNS
cord-302047-vv5gpldi	494	1	Synonymous	synonymous	JJ
cord-302047-vv5gpldi	494	2	Codon	Codon	NNP
cord-302047-vv5gpldi	494	3	Changes	change	NNS
cord-302047-vv5gpldi	494	4	in	in	IN
cord-302047-vv5gpldi	494	5	the	the	DT
cord-302047-vv5gpldi	494	6	Oncogenes	oncogene	NNS
cord-302047-vv5gpldi	494	7	of	of	IN
cord-302047-vv5gpldi	494	8	the	the	DT
cord-302047-vv5gpldi	494	9	Cottontail	Cottontail	NNP
cord-302047-vv5gpldi	494	10	Rabbit	Rabbit	NNP
cord-302047-vv5gpldi	494	11	Papillomavirus	Papillomavirus	NNP
cord-302047-vv5gpldi	494	12	Lead	lead	VB
cord-302047-vv5gpldi	494	13	to	to	IN
cord-302047-vv5gpldi	494	14	Increased	Increased	NNP
cord-302047-vv5gpldi	494	15	Oncogenicity	Oncogenicity	NNP
cord-302047-vv5gpldi	494	16	and	and	CC
cord-302047-vv5gpldi	494	17	Immunogenicity	Immunogenicity	NNP
cord-302047-vv5gpldi	494	18	of	of	IN
cord-302047-vv5gpldi	494	19	the	the	DT
cord-302047-vv5gpldi	494	20	Virus	Virus	NNP
cord-302047-vv5gpldi	494	21	Split	Split	NNP
cord-302047-vv5gpldi	494	22	Green	Green	NNP
cord-302047-vv5gpldi	494	23	Fluorescent	Fluorescent	NNP
cord-302047-vv5gpldi	494	24	Protein	Protein	NNP
cord-302047-vv5gpldi	494	25	as	as	IN
cord-302047-vv5gpldi	494	26	a	a	DT
cord-302047-vv5gpldi	494	27	Tool	tool	NN
cord-302047-vv5gpldi	494	28	to	to	TO
cord-302047-vv5gpldi	494	29	Study	study	VB
cord-302047-vv5gpldi	494	30	Infection	infection	NN
cord-302047-vv5gpldi	494	31	with	with	IN
cord-302047-vv5gpldi	494	32	a	a	DT
cord-302047-vv5gpldi	494	33	Plant	Plant	NNP
cord-302047-vv5gpldi	494	34	Pathogen	Pathogen	NNP
cord-302047-vv5gpldi	494	35	Modifications	modification	NNS
cord-302047-vv5gpldi	494	36	of	of	IN
cord-302047-vv5gpldi	494	37	the	the	DT
cord-302047-vv5gpldi	494	38	Tobacco	Tobacco	NNP
cord-302047-vv5gpldi	494	39	Mosaic	Mosaic	NNP
cord-302047-vv5gpldi	494	40	Virus	Virus	NNP
cord-302047-vv5gpldi	494	41	Coat	Coat	NNP
cord-302047-vv5gpldi	494	42	Protein	Protein	NNP
cord-302047-vv5gpldi	494	43	Gene	Gene	NNP
cord-302047-vv5gpldi	494	44	Affecting	Affecting	NNP
cord-302047-vv5gpldi	494	45	Replication	Replication	NNP
cord-302047-vv5gpldi	494	46	,	,	,
cord-302047-vv5gpldi	494	47	Movement	Movement	NNP
cord-302047-vv5gpldi	494	48	,	,	,
cord-302047-vv5gpldi	494	49	and	and	CC
cord-302047-vv5gpldi	494	50	Symptomatology	Symptomatology	NNP
cord-302047-vv5gpldi	494	51	A	A	NNP
cord-302047-vv5gpldi	495	1	Tobacco	Tobacco	NNP
cord-302047-vv5gpldi	495	2	Mosaic	Mosaic	NNP
cord-302047-vv5gpldi	495	3	Virus	virus	NN
cord-302047-vv5gpldi	495	4	-	-	HYPH
cord-302047-vv5gpldi	495	5	hybrid	hybrid	NN
cord-302047-vv5gpldi	495	6	Expresses	express	VBZ
cord-302047-vv5gpldi	495	7	and	and	CC
cord-302047-vv5gpldi	495	8	Loses	lose	VBZ
cord-302047-vv5gpldi	495	9	an	an	DT
cord-302047-vv5gpldi	495	10	Added	Added	NNP
cord-302047-vv5gpldi	495	11	Gene	Gene	NNP
cord-302047-vv5gpldi	495	12	A	A	NNP
cord-302047-vv5gpldi	495	13	Structured	Structured	NNP
cord-302047-vv5gpldi	495	14	Dynamic	Dynamic	NNP
cord-302047-vv5gpldi	495	15	Model	Model	NNP
cord-302047-vv5gpldi	495	16	for	for	IN
cord-302047-vv5gpldi	495	17	the	the	DT
cord-302047-vv5gpldi	495	18	Baculovirus	Baculovirus	NNP
cord-302047-vv5gpldi	495	19	Infection	Infection	NNP
cord-302047-vv5gpldi	495	20	Process	Process	NNP
cord-302047-vv5gpldi	495	21	in	in	IN
cord-302047-vv5gpldi	495	22	Insect	insect	NN
cord-302047-vv5gpldi	495	23	-	-	HYPH
cord-302047-vv5gpldi	495	24	cell	cell	NN
cord-302047-vv5gpldi	495	25	Reactor	reactor	NN
cord-302047-vv5gpldi	495	26	Configurations	Configurations	NNP
cord-302047-vv5gpldi	495	27	Empirical	Empirical	NNP
cord-302047-vv5gpldi	495	28	Fitness	Fitness	NNP
cord-302047-vv5gpldi	495	29	Landscapes	Landscapes	NNPS
cord-302047-vv5gpldi	495	30	and	and	CC
cord-302047-vv5gpldi	495	31	the	the	DT
cord-302047-vv5gpldi	495	32	Predictability	Predictability	NNP
cord-302047-vv5gpldi	495	33	of	of	IN
cord-302047-vv5gpldi	495	34	Evolution	Evolution	NNP
cord-302047-vv5gpldi	495	35	Potato	Potato	NNP
cord-302047-vv5gpldi	495	36	Virus	Virus	NNP
cord-302047-vv5gpldi	495	37	X	x	NN
cord-302047-vv5gpldi	495	38	-	-	HYPH
cord-302047-vv5gpldi	495	39	based	base	VBN
cord-302047-vv5gpldi	495	40	Expression	expression	NN
cord-302047-vv5gpldi	495	41	Vectors	vector	NNS
cord-302047-vv5gpldi	495	42	are	be	VBP
cord-302047-vv5gpldi	495	43	Stabilized	stabilize	VBN
cord-302047-vv5gpldi	495	44	for	for	IN
cord-302047-vv5gpldi	495	45	Long	long	JJ
cord-302047-vv5gpldi	495	46	-	-	HYPH
cord-302047-vv5gpldi	495	47	term	term	NN
cord-302047-vv5gpldi	495	48	Production	production	NN
cord-302047-vv5gpldi	495	49	of	of	IN
cord-302047-vv5gpldi	495	50	Proteins	Proteins	NNPS
cord-302047-vv5gpldi	495	51	and	and	CC
cord-302047-vv5gpldi	495	52	Larger	large	JJR
cord-302047-vv5gpldi	495	53	Inserts	Inserts	NNPS
cord-302047-vv5gpldi	495	54	Mutagenesis	Mutagenesis	NNP
cord-302047-vv5gpldi	495	55	of	of	IN
cord-302047-vv5gpldi	495	56	Cauliflower	Cauliflower	NNP
cord-302047-vv5gpldi	495	57	Mosaic	Mosaic	NNP
cord-302047-vv5gpldi	495	58	Virus	Virus	NNP
cord-302047-vv5gpldi	495	59	Tagging	Tagging	NNP
cord-302047-vv5gpldi	495	60	of	of	IN
cord-302047-vv5gpldi	495	61	Plant	Plant	NNP
cord-302047-vv5gpldi	495	62	Potyvirus	Potyvirus	NNP
cord-302047-vv5gpldi	495	63	Replication	Replication	NNP
cord-302047-vv5gpldi	495	64	and	and	CC
cord-302047-vv5gpldi	495	65	Movement	Movement	NNP
cord-302047-vv5gpldi	495	66	by	by	IN
cord-302047-vv5gpldi	495	67	Insertion	Insertion	NNP
cord-302047-vv5gpldi	495	68	of	of	IN
cord-302047-vv5gpldi	495	69	Beta	beta	NN
cord-302047-vv5gpldi	495	70	-	-	HYPH
cord-302047-vv5gpldi	495	71	glucuronidase	glucuronidase	NN
cord-302047-vv5gpldi	495	72	into	into	IN
cord-302047-vv5gpldi	495	73	the	the	DT
cord-302047-vv5gpldi	495	74	Viral	Viral	NNP
cord-302047-vv5gpldi	495	75	Polyprotein	Polyprotein	NNP
cord-302047-vv5gpldi	495	76	Systemic	Systemic	NNP
cord-302047-vv5gpldi	495	77	Expression	expression	NN
cord-302047-vv5gpldi	495	78	of	of	IN
cord-302047-vv5gpldi	495	79	a	a	DT
cord-302047-vv5gpldi	495	80	Bacterial	Bacterial	NNP
cord-302047-vv5gpldi	495	81	Gene	Gene	NNP
cord-302047-vv5gpldi	495	82	by	by	IN
cord-302047-vv5gpldi	495	83	a	a	DT
cord-302047-vv5gpldi	495	84	Tobacco	Tobacco	NNP
cord-302047-vv5gpldi	495	85	Mosaic	Mosaic	NNP
cord-302047-vv5gpldi	495	86	Virus	Virus	NNP
cord-302047-vv5gpldi	495	87	-	-	HYPH
cord-302047-vv5gpldi	495	88	based	base	VBN
cord-302047-vv5gpldi	495	89	Vector	Vector	NNP
cord-302047-vv5gpldi	495	90	Transgene	Transgene	NNP
cord-302047-vv5gpldi	495	91	Stability	stability	NN
cord-302047-vv5gpldi	495	92	for	for	IN
cord-302047-vv5gpldi	495	93	Three	three	CD
cord-302047-vv5gpldi	495	94	Replication	Replication	NNP
cord-302047-vv5gpldi	495	95	-	-	HYPH
cord-302047-vv5gpldi	495	96	competent	competent	JJ
cord-302047-vv5gpldi	496	1	Murine	Murine	NNP
cord-302047-vv5gpldi	496	2	Leukemia	Leukemia	NNP
cord-302047-vv5gpldi	496	3	Virus	Virus	NNP
cord-302047-vv5gpldi	496	4	Vectors	Vectors	NNP
cord-302047-vv5gpldi	496	5	'	'	POS
cord-302047-vv5gpldi	496	6	Gene	Gene	NNP
cord-302047-vv5gpldi	496	7	Therapy	Therapy	NNP
cord-302047-vv5gpldi	496	8	Clinical	Clinical	NNP
cord-302047-vv5gpldi	496	9	Trials	Trials	NNPS
cord-302047-vv5gpldi	496	10	Worldwide	Worldwide	NNP
cord-302047-vv5gpldi	496	11	1989	1989	CD
cord-302047-vv5gpldi	496	12	-	-	HYPH
cord-302047-vv5gpldi	496	13	2004-An	2004-an	CD
cord-302047-vv5gpldi	497	1	Overview	Overview	NNP
cord-302047-vv5gpldi	497	2	Poxviruses	Poxviruses	NNPS
cord-302047-vv5gpldi	497	3	Deploy	deploy	VBP
cord-302047-vv5gpldi	497	4	Genomic	Genomic	NNP
cord-302047-vv5gpldi	497	5	Accordions	Accordions	NNPS
cord-302047-vv5gpldi	498	1	to	to	TO
cord-302047-vv5gpldi	498	2	Adapt	adapt	VB
cord-302047-vv5gpldi	498	3	Rapidly	rapidly	RB
cord-302047-vv5gpldi	498	4	Against	against	IN
cord-302047-vv5gpldi	498	5	Host	Host	NNP
cord-302047-vv5gpldi	498	6	Antiviral	Antiviral	NNP
cord-302047-vv5gpldi	498	7	Defenses	Defenses	NNPS
cord-302047-vv5gpldi	498	8	Size	Size	NNP
cord-302047-vv5gpldi	498	9	Reversion	Reversion	NNP
cord-302047-vv5gpldi	498	10	of	of	IN
cord-302047-vv5gpldi	498	11	African	African	NNP
cord-302047-vv5gpldi	498	12	Cassava	Cassava	NNP
cord-302047-vv5gpldi	498	13	Mosaic	Mosaic	NNP
cord-302047-vv5gpldi	498	14	Virus	Virus	NNP
cord-302047-vv5gpldi	498	15	Coat	Coat	NNP
cord-302047-vv5gpldi	498	16	Protein	Protein	NNP
cord-302047-vv5gpldi	498	17	Gene	Gene	NNP
cord-302047-vv5gpldi	498	18	Deletion	deletion	NN
cord-302047-vv5gpldi	498	19	Mutants	mutant	NNS
cord-302047-vv5gpldi	498	20	During	during	IN
cord-302047-vv5gpldi	498	21	Infection	Infection	NNP
cord-302047-vv5gpldi	498	22	of	of	IN
cord-302047-vv5gpldi	498	23	Nicotiana	Nicotiana	NNP
cord-302047-vv5gpldi	498	24	benthamiana	benthamiana	NNP
cord-302047-vv5gpldi	498	25	Protein	Protein	NNP
cord-302047-vv5gpldi	498	26	Complex	Complex	NNP
cord-302047-vv5gpldi	498	27	Expression	expression	NN
cord-302047-vv5gpldi	498	28	by	by	IN
cord-302047-vv5gpldi	498	29	Using	use	VBG
cord-302047-vv5gpldi	498	30	Multigene	Multigene	NNP
cord-302047-vv5gpldi	498	31	Baculoviral	Baculoviral	NNP
cord-302047-vv5gpldi	498	32	Vectors	Vectors	NNPS
cord-302047-vv5gpldi	498	33	'	'	POS
cord-302047-vv5gpldi	498	34	Bacterial	bacterial	JJ
cord-302047-vv5gpldi	498	35	Gene	Gene	NNP
cord-302047-vv5gpldi	499	1	Inserted	insert	VBN
cord-302047-vv5gpldi	499	2	in	in	IN
cord-302047-vv5gpldi	499	3	an	an	DT
cord-302047-vv5gpldi	499	4	Engineered	Engineered	NNP
cord-302047-vv5gpldi	499	5	RNA	RNA	NNP
cord-302047-vv5gpldi	499	6	Virus	virus	NN
cord-302047-vv5gpldi	499	7	:	:	:
cord-302047-vv5gpldi	499	8	Efficient	efficient	JJ
cord-302047-vv5gpldi	499	9	Expression	expression	NN
cord-302047-vv5gpldi	499	10	in	in	IN
cord-302047-vv5gpldi	499	11	Monocotyledonous	Monocotyledonous	NNP
cord-302047-vv5gpldi	499	12	Plant	Plant	NNP
cord-302047-vv5gpldi	499	13	Cells	cell	NNS
cord-302047-vv5gpldi	500	1	The	the	DT
cord-302047-vv5gpldi	500	2	Size	Size	NNP
cord-302047-vv5gpldi	500	3	of	of	IN
cord-302047-vv5gpldi	500	4	Encapsidated	Encapsidated	NNP
cord-302047-vv5gpldi	500	5	Single	Single	NNP
cord-302047-vv5gpldi	500	6	-	-	HYPH
cord-302047-vv5gpldi	500	7	stranded	strand	VBN
cord-302047-vv5gpldi	500	8	DNA	dna	NN
cord-302047-vv5gpldi	500	9	Determines	determine	VBZ
cord-302047-vv5gpldi	500	10	the	the	DT
cord-302047-vv5gpldi	500	11	Multiplicity	Multiplicity	NNP
cord-302047-vv5gpldi	500	12	of	of	IN
cord-302047-vv5gpldi	500	13	African	african	JJ
cord-302047-vv5gpldi	500	14	Cassava	Cassava	NNP
cord-302047-vv5gpldi	500	15	Mosaic	Mosaic	NNP
cord-302047-vv5gpldi	500	16	Virus	Virus	NNP
cord-302047-vv5gpldi	500	17	Particles	particle	NNS
cord-302047-vv5gpldi	500	18	CpG	CpG	NNP
cord-302047-vv5gpldi	500	19	and	and	CC
cord-302047-vv5gpldi	500	20	UpA	UpA	NNP
cord-302047-vv5gpldi	500	21	Dinucleotides	Dinucleotides	NNP
cord-302047-vv5gpldi	500	22	in	in	IN
cord-302047-vv5gpldi	500	23	Both	both	CC
cord-302047-vv5gpldi	500	24	Coding	Coding	NNP
cord-302047-vv5gpldi	500	25	and	and	CC
cord-302047-vv5gpldi	500	26	Non	non	JJ
cord-302047-vv5gpldi	500	27	-	-	NN
cord-302047-vv5gpldi	500	28	coding	coding	JJ
cord-302047-vv5gpldi	500	29	Regions	region	NNS
cord-302047-vv5gpldi	500	30	of	of	IN
cord-302047-vv5gpldi	500	31	Echovirus	Echovirus	NNP
cord-302047-vv5gpldi	500	32	7	7	CD
cord-302047-vv5gpldi	501	1	Inhibit	inhibit	NN
cord-302047-vv5gpldi	501	2	Replication	replication	NN
cord-302047-vv5gpldi	501	3	Initiation	Initiation	NNP
cord-302047-vv5gpldi	501	4	Post	post	NN
cord-302047-vv5gpldi	501	5	-	-	NN
cord-302047-vv5gpldi	501	6	entry	entry	NN
cord-302047-vv5gpldi	501	7	'	'	''
cord-302047-vv5gpldi	501	8	,	,	,
cord-302047-vv5gpldi	501	9	eLife	eLife	NNP
cord-302047-vv5gpldi	501	10	Correction	correction	NN
cord-302047-vv5gpldi	501	11	:	:	:
cord-302047-vv5gpldi	501	12	Characterization	characterization	NN
cord-302047-vv5gpldi	501	13	of	of	IN
cord-302047-vv5gpldi	501	14	HBV	HBV	NNP
cord-302047-vv5gpldi	501	15	Integration	Integration	NNP
cord-302047-vv5gpldi	501	16	Patterns	Patterns	NNPS
cord-302047-vv5gpldi	501	17	and	and	CC
cord-302047-vv5gpldi	501	18	Timing	time	VBG
cord-302047-vv5gpldi	501	19	in	in	IN
cord-302047-vv5gpldi	501	20	Liver	Liver	NNP
cord-302047-vv5gpldi	501	21	Cancer	Cancer	NNP
cord-302047-vv5gpldi	501	22	and	and	CC
cord-302047-vv5gpldi	501	23	HBV	HBV	NNP
cord-302047-vv5gpldi	501	24	-	-	HYPH
cord-302047-vv5gpldi	501	25	infected	infect	VBN
cord-302047-vv5gpldi	501	26	Livers	liver	NNS
cord-302047-vv5gpldi	501	27	Properties	Properties	NNPS
cord-302047-vv5gpldi	501	28	of	of	IN
cord-302047-vv5gpldi	501	29	Replication	replication	NN
cord-302047-vv5gpldi	501	30	-	-	HYPH
cord-302047-vv5gpldi	501	31	competent	competent	JJ
cord-302047-vv5gpldi	501	32	Vesicular	Vesicular	NNP
cord-302047-vv5gpldi	501	33	Stomatitis	Stomatitis	NNP
cord-302047-vv5gpldi	501	34	Virus	virus	NN
cord-302047-vv5gpldi	501	35	Vectors	vector	NNS
cord-302047-vv5gpldi	502	1	Expressing	express	VBG
cord-302047-vv5gpldi	502	2	Glycoproteins	Glycoproteins	NNP
cord-302047-vv5gpldi	502	3	of	of	IN
cord-302047-vv5gpldi	502	4	Filoviruses	Filoviruses	NNPS
cord-302047-vv5gpldi	502	5	and	and	CC
cord-302047-vv5gpldi	502	6	Arenaviruses	Arenaviruses	NNP
cord-302047-vv5gpldi	502	7	Clinical	Clinical	NNP
cord-302047-vv5gpldi	502	8	Development	Development	NNP
cord-302047-vv5gpldi	502	9	of	of	IN
cord-302047-vv5gpldi	502	10	Modified	Modified	NNP
cord-302047-vv5gpldi	502	11	Vaccinia	Vaccinia	NNP
cord-302047-vv5gpldi	502	12	Virus	Virus	NNP
cord-302047-vv5gpldi	502	13	Ankara	Ankara	NNP
cord-302047-vv5gpldi	502	14	Vaccines	Vaccines	NNPS
cord-302047-vv5gpldi	502	15	Evolutionary	Evolutionary	NNP
cord-302047-vv5gpldi	502	16	Principles	Principles	NNPS
cord-302047-vv5gpldi	502	17	and	and	CC
cord-302047-vv5gpldi	502	18	Synthetic	synthetic	JJ
cord-302047-vv5gpldi	502	19	Biology	biology	NN
cord-302047-vv5gpldi	502	20	:	:	:
cord-302047-vv5gpldi	503	1	Avoiding	avoid	VBG
cord-302047-vv5gpldi	503	2	a	a	DT
cord-302047-vv5gpldi	503	3	Molecular	Molecular	NNP
cord-302047-vv5gpldi	503	4	Tragedy	Tragedy	NNP
cord-302047-vv5gpldi	503	5	of	of	IN
cord-302047-vv5gpldi	503	6	the	the	DT
cord-302047-vv5gpldi	503	7	Commons	Commons	NNPS
cord-302047-vv5gpldi	503	8	with	with	IN
cord-302047-vv5gpldi	503	9	an	an	DT
cord-302047-vv5gpldi	503	10	Engineered	engineer	VBN
cord-302047-vv5gpldi	503	11	Phage	Phage	NNP
cord-302047-vv5gpldi	503	12	Poxvirus	Poxvirus	NNP
cord-302047-vv5gpldi	503	13	Vectors	Vectors	NNP
cord-302047-vv5gpldi	503	14	as	as	IN
cord-302047-vv5gpldi	503	15	HIV	HIV	NNP
cord-302047-vv5gpldi	503	16	/	/	SYM
cord-302047-vv5gpldi	503	17	AIDS	AIDS	NNP
cord-302047-vv5gpldi	503	18	Vaccines	Vaccines	NNPS
cord-302047-vv5gpldi	503	19	in	in	IN
cord-302047-vv5gpldi	503	20	Humans	Humans	NNP
cord-302047-vv5gpldi	503	21	Propagation	Propagation	NNP
cord-302047-vv5gpldi	503	22	of	of	IN
cord-302047-vv5gpldi	503	23	Foreign	Foreign	NNP
cord-302047-vv5gpldi	503	24	DNA	DNA	NNP
cord-302047-vv5gpldi	503	25	in	in	IN
cord-302047-vv5gpldi	503	26	Plants	plant	NNS
cord-302047-vv5gpldi	503	27	Using	use	VBG
cord-302047-vv5gpldi	503	28	Cauliflower	Cauliflower	NNP
cord-302047-vv5gpldi	503	29	Mosaic	Mosaic	NNP
cord-302047-vv5gpldi	503	30	Virus	Virus	NNP
cord-302047-vv5gpldi	503	31	as	as	IN
cord-302047-vv5gpldi	503	32	Vector	Vector	NNP
cord-302047-vv5gpldi	503	33	Susceptibility	Susceptibility	NNP
cord-302047-vv5gpldi	503	34	to	to	IN
cord-302047-vv5gpldi	503	35	Recombination	recombination	NN
cord-302047-vv5gpldi	503	36	Rearrangements	rearrangement	NNS
cord-302047-vv5gpldi	503	37	of	of	IN
cord-302047-vv5gpldi	503	38	a	a	DT
cord-302047-vv5gpldi	503	39	Chimeric	Chimeric	NNP
cord-302047-vv5gpldi	503	40	Plum	Plum	NNP
cord-302047-vv5gpldi	503	41	Pox	Pox	NNP
cord-302047-vv5gpldi	503	42	Potyvirus	Potyvirus	NNP
cord-302047-vv5gpldi	503	43	Genome	Genome	NNP
cord-302047-vv5gpldi	503	44	After	after	IN
cord-302047-vv5gpldi	503	45	Insertion	Insertion	NNP
cord-302047-vv5gpldi	503	46	of	of	IN
cord-302047-vv5gpldi	503	47	a	a	DT
cord-302047-vv5gpldi	503	48	Foreign	Foreign	NNP
cord-302047-vv5gpldi	503	49	Gene	Gene	NNP
cord-302047-vv5gpldi	503	50	LMO2-Associated	lmo2-associate	VBN
cord-302047-vv5gpldi	503	51	Clonal	Clonal	NNP
cord-302047-vv5gpldi	503	52	T	T	NNP
cord-302047-vv5gpldi	503	53	Cell	cell	NN
cord-302047-vv5gpldi	503	54	Proliferation	proliferation	NN
cord-302047-vv5gpldi	503	55	in	in	IN
cord-302047-vv5gpldi	503	56	Two	two	CD
cord-302047-vv5gpldi	503	57	Patients	patient	NNS
cord-302047-vv5gpldi	503	58	After	after	IN
cord-302047-vv5gpldi	503	59	Gene	Gene	NNP
cord-302047-vv5gpldi	503	60	Therapy	Therapy	NNP
cord-302047-vv5gpldi	503	61	for	for	IN
cord-302047-vv5gpldi	503	62	SCID	SCID	NNP
cord-302047-vv5gpldi	503	63	-	-	HYPH
cord-302047-vv5gpldi	503	64	X1	X1	NNP
cord-302047-vv5gpldi	503	65	Homologous	Homologous	NNP
cord-302047-vv5gpldi	503	66	Recombination	Recombination	NNP
cord-302047-vv5gpldi	503	67	in	in	IN
cord-302047-vv5gpldi	503	68	Negative	negative	JJ
cord-302047-vv5gpldi	503	69	Sense	sense	NN
cord-302047-vv5gpldi	504	1	RNA	RNA	NNP
cord-302047-vv5gpldi	504	2	Viruses	Viruses	NNPS
cord-302047-vv5gpldi	504	3	Stability	Stability	NNP
cord-302047-vv5gpldi	504	4	and	and	CC
cord-302047-vv5gpldi	504	5	Expression	expression	NN
cord-302047-vv5gpldi	504	6	of	of	IN
cord-302047-vv5gpldi	504	7	Bacterial	bacterial	JJ
cord-302047-vv5gpldi	504	8	Genes	Genes	NNPS
cord-302047-vv5gpldi	504	9	in	in	IN
cord-302047-vv5gpldi	504	10	Replicating	replicate	VBG
cord-302047-vv5gpldi	504	11	Geminivirus	Geminivirus	NNP
cord-302047-vv5gpldi	504	12	Vectors	Vectors	NNPS
cord-302047-vv5gpldi	504	13	in	in	IN
cord-302047-vv5gpldi	504	14	Plants	Plants	NNP
cord-302047-vv5gpldi	504	15	Rescue	Rescue	NNP
cord-302047-vv5gpldi	504	16	of	of	IN
cord-302047-vv5gpldi	504	17	In	in	IN
cord-302047-vv5gpldi	504	18	Vitro	Vitro	NNP
cord-302047-vv5gpldi	504	19	Generated	generate	VBN
cord-302047-vv5gpldi	504	20	Mutants	mutant	NNS
cord-302047-vv5gpldi	504	21	of	of	IN
cord-302047-vv5gpldi	504	22	Cloned	Cloned	NNP
cord-302047-vv5gpldi	504	23	Cauliflower	Cauliflower	NNP
cord-302047-vv5gpldi	504	24	Mosaic	Mosaic	NNP
cord-302047-vv5gpldi	504	25	Virus	Virus	NNP
cord-302047-vv5gpldi	504	26	Genome	Genome	NNP
cord-302047-vv5gpldi	504	27	in	in	IN
cord-302047-vv5gpldi	504	28	Infected	Infected	NNP
cord-302047-vv5gpldi	504	29	Plants	plant	NNS
cord-302047-vv5gpldi	504	30	Defective	defective	JJ
cord-302047-vv5gpldi	504	31	Interfering	interfere	VBG
cord-302047-vv5gpldi	504	32	Viruses	virus	NNS
cord-302047-vv5gpldi	504	33	Localized	localize	VBN
cord-302047-vv5gpldi	504	34	Attenuation	Attenuation	NNP
cord-302047-vv5gpldi	504	35	and	and	CC
cord-302047-vv5gpldi	504	36	Discontinuous	Discontinuous	NNP
cord-302047-vv5gpldi	504	37	Synthesis	Synthesis	NNP
cord-302047-vv5gpldi	505	1	During	during	IN
cord-302047-vv5gpldi	505	2	Vesicular	Vesicular	NNP
cord-302047-vv5gpldi	505	3	Stomatitis	Stomatitis	NNP
cord-302047-vv5gpldi	505	4	Virus	Virus	NNP
cord-302047-vv5gpldi	505	5	Transcription	Transcription	NNP
cord-302047-vv5gpldi	505	6	High	High	NNP
cord-302047-vv5gpldi	505	7	Rate	rate	NN
cord-302047-vv5gpldi	505	8	of	of	IN
cord-302047-vv5gpldi	505	9	Recombination	Recombination	NNP
cord-302047-vv5gpldi	505	10	Throughout	throughout	IN
cord-302047-vv5gpldi	505	11	the	the	DT
cord-302047-vv5gpldi	505	12	Human	Human	NNP
cord-302047-vv5gpldi	505	13	Immunodeficiency	Immunodeficiency	NNP
cord-302047-vv5gpldi	505	14	Virus	Virus	NNP
cord-302047-vv5gpldi	505	15	Type	Type	NNP
cord-302047-vv5gpldi	505	16	1	1	CD
cord-302047-vv5gpldi	505	17	Genome	Genome	NNP
cord-302047-vv5gpldi	505	18	Specific	specific	NN
cord-302047-vv5gpldi	505	19	Targeting	target	VBG
cord-302047-vv5gpldi	505	20	to	to	IN
cord-302047-vv5gpldi	505	21	CD4þ	CD4þ	NNP
cord-302047-vv5gpldi	505	22	Cells	Cells	NNPS
cord-302047-vv5gpldi	505	23	of	of	IN
cord-302047-vv5gpldi	505	24	Recombinant	Recombinant	NNP
cord-302047-vv5gpldi	505	25	Vesicular	Vesicular	NNP
cord-302047-vv5gpldi	505	26	Stomatitis	Stomatitis	NNP
cord-302047-vv5gpldi	505	27	Viruses	virus	NNS
cord-302047-vv5gpldi	506	1	Encoding	encode	VBG
cord-302047-vv5gpldi	506	2	Human	Human	NNP
cord-302047-vv5gpldi	506	3	Immunodeficiency	Immunodeficiency	NNP
cord-302047-vv5gpldi	506	4	Virus	Virus	NNP
cord-302047-vv5gpldi	506	5	Envelope	Envelope	NNP
cord-302047-vv5gpldi	507	1	Proteins	protein	NNS
cord-302047-vv5gpldi	507	2	BSMV	BSMV	NNP
cord-302047-vv5gpldi	508	1	Genome	genome	NN
cord-302047-vv5gpldi	508	2	Mediated	mediate	VBN
cord-302047-vv5gpldi	508	3	Expression	expression	NN
cord-302047-vv5gpldi	508	4	of	of	IN
cord-302047-vv5gpldi	508	5	a	a	DT
cord-302047-vv5gpldi	508	6	Foreign	Foreign	NNP
cord-302047-vv5gpldi	508	7	Gene	Gene	NNP
cord-302047-vv5gpldi	508	8	in	in	IN
cord-302047-vv5gpldi	508	9	Dicot	Dicot	NNP
cord-302047-vv5gpldi	508	10	and	and	CC
cord-302047-vv5gpldi	508	11	Monocot	Monocot	NNP
cord-302047-vv5gpldi	508	12	Plant	Plant	NNP
cord-302047-vv5gpldi	508	13	Cells	cell	NNS
cord-302047-vv5gpldi	509	1	Entirely	entirely	RB
cord-302047-vv5gpldi	509	2	Plasmid	Plasmid	NNP
cord-302047-vv5gpldi	509	3	-	-	HYPH
cord-302047-vv5gpldi	509	4	based	base	VBN
cord-302047-vv5gpldi	509	5	Reverse	Reverse	NNP
cord-302047-vv5gpldi	509	6	Genetics	Genetics	NNP
cord-302047-vv5gpldi	509	7	System	System	NNP
cord-302047-vv5gpldi	509	8	for	for	IN
cord-302047-vv5gpldi	509	9	Rotaviruses	Rotaviruses	NNP
cord-302047-vv5gpldi	510	1	In	in	IN
cord-302047-vv5gpldi	510	2	Vitro	Vitro	NNP
cord-302047-vv5gpldi	510	3	and	and	CC
cord-302047-vv5gpldi	510	4	In	in	IN
cord-302047-vv5gpldi	510	5	Vivo	Vivo	NNP
cord-302047-vv5gpldi	510	6	Genetic	Genetic	NNP
cord-302047-vv5gpldi	510	7	Stability	Stability	NNP
cord-302047-vv5gpldi	510	8	Studies	Studies	NNPS
cord-302047-vv5gpldi	510	9	of	of	IN
cord-302047-vv5gpldi	510	10	a	a	DT
cord-302047-vv5gpldi	510	11	Human	Human	NNP
cord-302047-vv5gpldi	510	12	Adenovirus	Adenovirus	NNP
cord-302047-vv5gpldi	510	13	Type	Type	NNP
cord-302047-vv5gpldi	510	14	5	5	CD
cord-302047-vv5gpldi	510	15	Recombinant	Recombinant	NNP
cord-302047-vv5gpldi	510	16	Rabies	Rabies	NNP
cord-302047-vv5gpldi	510	17	Glycoprotein	Glycoprotein	NNP
cord-302047-vv5gpldi	510	18	Vaccine	Vaccine	NNP
cord-302047-vv5gpldi	510	19	(	(	-LRB-
cord-302047-vv5gpldi	510	20	ONRAB	ONRAB	NNP
cord-302047-vv5gpldi	510	21	)	)	-RRB-
cord-302047-vv5gpldi	510	22	'	'	''
cord-302047-vv5gpldi	510	23	,	,	,
cord-302047-vv5gpldi	510	24	Vaccine	Vaccine	NNP
cord-302047-vv5gpldi	510	25	Reverse	Reverse	NNP
cord-302047-vv5gpldi	510	26	Genetics	Genetics	NNP
cord-302047-vv5gpldi	510	27	System	system	NN
cord-302047-vv5gpldi	510	28	Demonstrates	demonstrate	VBZ
cord-302047-vv5gpldi	510	29	That	that	IN
cord-302047-vv5gpldi	510	30	Rotavirus	Rotavirus	NNP
cord-302047-vv5gpldi	510	31	Nonstructural	Nonstructural	NNP
cord-302047-vv5gpldi	510	32	Protein	Protein	NNP
cord-302047-vv5gpldi	510	33	NSP6	NSP6	NNP
cord-302047-vv5gpldi	510	34	is	be	VBZ
cord-302047-vv5gpldi	510	35	Not	not	RB
cord-302047-vv5gpldi	510	36	Essential	essential	JJ
cord-302047-vv5gpldi	510	37	for	for	IN
cord-302047-vv5gpldi	510	38	Viral	viral	JJ
cord-302047-vv5gpldi	510	39	Replication	Replication	NNP
cord-302047-vv5gpldi	510	40	in	in	IN
cord-302047-vv5gpldi	510	41	Cell	cell	NN
cord-302047-vv5gpldi	510	42	Culture	Culture	NNP
cord-302047-vv5gpldi	510	43	Detection	Detection	NNP
cord-302047-vv5gpldi	510	44	and	and	CC
cord-302047-vv5gpldi	510	45	Analysis	Analysis	NNP
cord-302047-vv5gpldi	510	46	of	of	IN
cord-302047-vv5gpldi	510	47	Autographa	Autographa	NNP
cord-302047-vv5gpldi	510	48	californica	californica	NNP
cord-302047-vv5gpldi	510	49	Nuclear	Nuclear	NNP
cord-302047-vv5gpldi	510	50	Polyhedrosis	Polyhedrosis	NNP
cord-302047-vv5gpldi	510	51	Virus	Virus	NNP
cord-302047-vv5gpldi	510	52	Mutants	Mutants	NNPS
cord-302047-vv5gpldi	510	53	with	with	IN
cord-302047-vv5gpldi	510	54	Defective	defective	JJ
cord-302047-vv5gpldi	510	55	Interfering	Interfering	NNP
cord-302047-vv5gpldi	510	56	Properties	Properties	NNPS
cord-302047-vv5gpldi	510	57	Evolution	Evolution	NNP
cord-302047-vv5gpldi	510	58	and	and	CC
cord-302047-vv5gpldi	510	59	Taxonomy	Taxonomy	NNP
cord-302047-vv5gpldi	510	60	of	of	IN
cord-302047-vv5gpldi	510	61	Positive	positive	JJ
cord-302047-vv5gpldi	510	62	-	-	HYPH
cord-302047-vv5gpldi	510	63	strand	strand	NN
cord-302047-vv5gpldi	510	64	RNA	RNA	NNP
cord-302047-vv5gpldi	510	65	Viruses	virus	NNS
cord-302047-vv5gpldi	510	66	:	:	:
cord-302047-vv5gpldi	510	67	Implications	implication	NNS
cord-302047-vv5gpldi	510	68	of	of	IN
cord-302047-vv5gpldi	510	69	Comparative	Comparative	NNP
cord-302047-vv5gpldi	510	70	Analysis	Analysis	NNP
cord-302047-vv5gpldi	510	71	of	of	IN
cord-302047-vv5gpldi	510	72	Amino	Amino	NNP
cord-302047-vv5gpldi	510	73	Acid	acid	NN
cord-302047-vv5gpldi	510	74	Sequences	Sequences	NNPS
cord-302047-vv5gpldi	510	75	Vaccination	vaccination	NN
cord-302047-vv5gpldi	510	76	Against	against	IN
cord-302047-vv5gpldi	510	77	Rabies	Rabies	NNP
cord-302047-vv5gpldi	510	78	:	:	:
cord-302047-vv5gpldi	511	1	Construction	construction	NN
cord-302047-vv5gpldi	511	2	and	and	CC
cord-302047-vv5gpldi	511	3	Characterization	characterization	NN
cord-302047-vv5gpldi	511	4	of	of	IN
cord-302047-vv5gpldi	511	5	SAG2	SAG2	NNP
cord-302047-vv5gpldi	511	6	,	,	,
cord-302047-vv5gpldi	511	7	a	a	DT
cord-302047-vv5gpldi	511	8	Double	Double	NNP
cord-302047-vv5gpldi	511	9	Avirulent	Avirulent	NNP
cord-302047-vv5gpldi	511	10	Derivative	Derivative	NNP
cord-302047-vv5gpldi	511	11	of	of	IN
cord-302047-vv5gpldi	511	12	SADBern	sadbern	JJ
cord-302047-vv5gpldi	511	13	Mammalian	Mammalian	NNP
cord-302047-vv5gpldi	511	14	Metallothionein	Metallothionein	NNP
cord-302047-vv5gpldi	511	15	Functions	Functions	NNPS
cord-302047-vv5gpldi	511	16	in	in	IN
cord-302047-vv5gpldi	511	17	Plants	plant	NNS
cord-302047-vv5gpldi	512	1	A	a	DT
cord-302047-vv5gpldi	512	2	Recombinant	recombinant	JJ
cord-302047-vv5gpldi	512	3	Canine	Canine	NNP
cord-302047-vv5gpldi	512	4	Distemper	Distemper	NNP
cord-302047-vv5gpldi	512	5	Virus	virus	NN
cord-302047-vv5gpldi	512	6	Expressing	express	VBG
cord-302047-vv5gpldi	512	7	a	a	DT
cord-302047-vv5gpldi	512	8	Modified	Modified	NNP
cord-302047-vv5gpldi	512	9	Rabies	Rabies	NNP
cord-302047-vv5gpldi	512	10	Virus	Virus	NNP
cord-302047-vv5gpldi	512	11	Glycoprotein	Glycoprotein	NNP
cord-302047-vv5gpldi	512	12	Induces	induce	VBZ
cord-302047-vv5gpldi	512	13	Immune	immune	JJ
cord-302047-vv5gpldi	512	14	Responses	response	NNS
cord-302047-vv5gpldi	512	15	in	in	IN
cord-302047-vv5gpldi	512	16	Mice	Mice	NNP
cord-302047-vv5gpldi	512	17	Rescue	Rescue	NNP
cord-302047-vv5gpldi	512	18	and	and	CC
cord-302047-vv5gpldi	512	19	Evaluation	Evaluation	NNP
cord-302047-vv5gpldi	512	20	of	of	IN
cord-302047-vv5gpldi	512	21	a	a	DT
cord-302047-vv5gpldi	512	22	Recombinant	recombinant	JJ
cord-302047-vv5gpldi	512	23	PRRSV	PRRSV	NNP
cord-302047-vv5gpldi	513	1	Expressing	express	VBG
cord-302047-vv5gpldi	513	2	Porcine	Porcine	NNP
cord-302047-vv5gpldi	513	3	Interleukin-4	Interleukin-4	NNP
cord-302047-vv5gpldi	513	4	'	'	POS
cord-302047-vv5gpldi	513	5	Genomic	genomic	JJ
cord-302047-vv5gpldi	513	6	Stability	stability	NN
cord-302047-vv5gpldi	513	7	of	of	IN
cord-302047-vv5gpldi	513	8	Murine	Murine	NNP
cord-302047-vv5gpldi	513	9	Leukemia	Leukemia	NNP
cord-302047-vv5gpldi	513	10	Viruses	virus	NNS
cord-302047-vv5gpldi	513	11	Containing	contain	VBG
cord-302047-vv5gpldi	513	12	Insertions	insertion	NNS
cord-302047-vv5gpldi	513	13	at	at	IN
cord-302047-vv5gpldi	513	14	the	the	DT
cord-302047-vv5gpldi	513	15	Env	Env	NNP
cord-302047-vv5gpldi	513	16	3	3	NNP
cord-302047-vv5gpldi	513	17	'	'	POS
cord-302047-vv5gpldi	513	18	Untranslated	Untranslated	NNP
cord-302047-vv5gpldi	513	19	Region	Region	NNP
cord-302047-vv5gpldi	513	20	Boundary	Boundary	NNP
cord-302047-vv5gpldi	513	21	Dispersing	disperse	VBG
cord-302047-vv5gpldi	513	22	Biofilms	Biofilms	NNP
cord-302047-vv5gpldi	513	23	with	with	IN
cord-302047-vv5gpldi	513	24	Engineered	Engineered	NNP
cord-302047-vv5gpldi	513	25	Enzymatic	Enzymatic	NNP
cord-302047-vv5gpldi	513	26	Bacteriophage	Bacteriophage	NNP
cord-302047-vv5gpldi	513	27	Mutation	Mutation	NNP
cord-302047-vv5gpldi	513	28	Load	Load	NNP
cord-302047-vv5gpldi	513	29	and	and	CC
cord-302047-vv5gpldi	513	30	the	the	DT
cord-302047-vv5gpldi	513	31	Survival	Survival	NNP
cord-302047-vv5gpldi	513	32	of	of	IN
cord-302047-vv5gpldi	513	33	Small	Small	NNP
cord-302047-vv5gpldi	513	34	Populations	Populations	NNPS
cord-302047-vv5gpldi	513	35	Elimination	Elimination	NNP
cord-302047-vv5gpldi	513	36	of	of	IN
cord-302047-vv5gpldi	513	37	Rabies	Rabies	NNP
cord-302047-vv5gpldi	513	38	from	from	IN
cord-302047-vv5gpldi	513	39	Red	Red	NNP
cord-302047-vv5gpldi	513	40	Foxes	Foxes	NNPS
cord-302047-vv5gpldi	513	41	in	in	IN
cord-302047-vv5gpldi	513	42	Eastern	Eastern	NNP
cord-302047-vv5gpldi	513	43	Ontario	Ontario	NNP
cord-302047-vv5gpldi	513	44	Stability	Stability	NNP
cord-302047-vv5gpldi	513	45	and	and	CC
cord-302047-vv5gpldi	513	46	Fitness	Fitness	NNP
cord-302047-vv5gpldi	513	47	Impact	Impact	NNP
cord-302047-vv5gpldi	513	48	of	of	IN
cord-302047-vv5gpldi	513	49	the	the	DT
cord-302047-vv5gpldi	513	50	Visually	visually	RB
cord-302047-vv5gpldi	513	51	Discernible	discernible	JJ
cord-302047-vv5gpldi	513	52	Rosea1	Rosea1	NNP
cord-302047-vv5gpldi	513	53	Marker	Marker	NNP
cord-302047-vv5gpldi	513	54	in	in	IN
cord-302047-vv5gpldi	513	55	the	the	DT
cord-302047-vv5gpldi	513	56	Tobacco	Tobacco	NNP
cord-302047-vv5gpldi	513	57	Etch	Etch	NNP
cord-302047-vv5gpldi	513	58	Virus	Virus	NNP
cord-302047-vv5gpldi	513	59	Genome	Genome	NNP
cord-302047-vv5gpldi	513	60	A	A	NNP
cord-302047-vv5gpldi	513	61	Highly	highly	RB
cord-302047-vv5gpldi	513	62	Immunogenic	immunogenic	JJ
cord-302047-vv5gpldi	513	63	and	and	CC
cord-302047-vv5gpldi	513	64	Protective	Protective	NNP
cord-302047-vv5gpldi	513	65	Middle	Middle	NNP
cord-302047-vv5gpldi	513	66	East	East	NNP
cord-302047-vv5gpldi	513	67	Respiratory	Respiratory	NNP
cord-302047-vv5gpldi	513	68	Syndrome	Syndrome	NNP
cord-302047-vv5gpldi	513	69	Coronavirus	Coronavirus	NNP
cord-302047-vv5gpldi	513	70	Vaccine	Vaccine	NNP
cord-302047-vv5gpldi	514	1	Based	base	VBN
cord-302047-vv5gpldi	514	2	on	on	IN
cord-302047-vv5gpldi	514	3	a	a	DT
cord-302047-vv5gpldi	514	4	Recombinant	Recombinant	NNP
cord-302047-vv5gpldi	514	5	Measles	Measles	NNP
cord-302047-vv5gpldi	514	6	Virus	Virus	NNP
cord-302047-vv5gpldi	514	7	Vaccine	Vaccine	NNP
cord-302047-vv5gpldi	514	8	Platform	Platform	NNP
cord-302047-vv5gpldi	514	9	Recombination	Recombination	NNP
cord-302047-vv5gpldi	514	10	in	in	IN
cord-302047-vv5gpldi	514	11	Eukaryotic	Eukaryotic	NNP
cord-302047-vv5gpldi	514	12	Single	Single	NNP
cord-302047-vv5gpldi	514	13	Stranded	strand	VBN
cord-302047-vv5gpldi	514	14	DNA	dna	NN
cord-302047-vv5gpldi	514	15	Viruses	virus	NNS
cord-302047-vv5gpldi	515	1	The	the	DT
cord-302047-vv5gpldi	515	2	Shift	Shift	NNP
cord-302047-vv5gpldi	515	3	from	from	IN
cord-302047-vv5gpldi	515	4	Low	Low	NNP
cord-302047-vv5gpldi	515	5	to	to	IN
cord-302047-vv5gpldi	515	6	High	high	JJ
cord-302047-vv5gpldi	515	7	Non	non	JJ
cord-302047-vv5gpldi	515	8	-	-	JJ
cord-302047-vv5gpldi	515	9	structural	structural	JJ
cord-302047-vv5gpldi	515	10	Protein	Protein	NNP
cord-302047-vv5gpldi	515	11	1	1	CD
cord-302047-vv5gpldi	515	12	Expression	expression	NN
cord-302047-vv5gpldi	515	13	in	in	IN
cord-302047-vv5gpldi	515	14	Rotavirus	rotavirus	NN
cord-302047-vv5gpldi	515	15	-	-	HYPH
cord-302047-vv5gpldi	515	16	infected	infect	VBN
cord-302047-vv5gpldi	515	17	MA-104	MA-104	NNP
cord-302047-vv5gpldi	515	18	Cells	Cells	NNP
cord-302047-vv5gpldi	515	19	'	'	POS
cord-302047-vv5gpldi	515	20	,	,	,
cord-302047-vv5gpldi	515	21	Memó	Memó	NNP
cord-302047-vv5gpldi	515	22	rias	ria	NNS
cord-302047-vv5gpldi	515	23	do	do	VBP
cord-302047-vv5gpldi	515	24	Instituto	Instituto	NNP
cord-302047-vv5gpldi	515	25	Oswaldo	Oswaldo	NNP
cord-302047-vv5gpldi	515	26	Cruz	Cruz	NNP
cord-302047-vv5gpldi	516	1	Attenuated	attenuated	JJ
cord-302047-vv5gpldi	516	2	Poliovirus	Poliovirus	NNP
cord-302047-vv5gpldi	516	3	Strain	Strain	NNP
cord-302047-vv5gpldi	516	4	as	as	IN
cord-302047-vv5gpldi	516	5	a	a	DT
cord-302047-vv5gpldi	516	6	Live	live	JJ
cord-302047-vv5gpldi	516	7	Vector	vector	NN
cord-302047-vv5gpldi	516	8	:	:	:
cord-302047-vv5gpldi	516	9	Expression	expression	NN
cord-302047-vv5gpldi	516	10	of	of	IN
cord-302047-vv5gpldi	516	11	Regions	Regions	NNPS
cord-302047-vv5gpldi	516	12	of	of	IN
cord-302047-vv5gpldi	516	13	Rotavirus	Rotavirus	NNP
cord-302047-vv5gpldi	516	14	Outer	Outer	NNP
cord-302047-vv5gpldi	516	15	Capsid	Capsid	NNP
cord-302047-vv5gpldi	516	16	Protein	Protein	NNP
cord-302047-vv5gpldi	516	17	VP7	vp7	NN
cord-302047-vv5gpldi	516	18	by	by	IN
cord-302047-vv5gpldi	516	19	Using	use	VBG
cord-302047-vv5gpldi	516	20	Recombinant	Recombinant	NNP
cord-302047-vv5gpldi	516	21	Sabin	Sabin	NNP
cord-302047-vv5gpldi	516	22	3	3	CD
cord-302047-vv5gpldi	516	23	Viruses	Viruses	NNPS
cord-302047-vv5gpldi	516	24	Influence	Influence	NNP
cord-302047-vv5gpldi	516	25	of	of	IN
cord-302047-vv5gpldi	516	26	Genome	genome	NN
cord-302047-vv5gpldi	516	27	-	-	HYPH
cord-302047-vv5gpldi	516	28	scale	scale	NN
cord-302047-vv5gpldi	516	29	RNA	RNA	NNP
cord-302047-vv5gpldi	516	30	Structure	Structure	NNP
cord-302047-vv5gpldi	516	31	Disruption	Disruption	NNP
cord-302047-vv5gpldi	516	32	on	on	IN
cord-302047-vv5gpldi	516	33	the	the	DT
cord-302047-vv5gpldi	516	34	Replication	replication	NN
cord-302047-vv5gpldi	516	35	of	of	IN
cord-302047-vv5gpldi	516	36	Murine	Murine	NNP
cord-302047-vv5gpldi	516	37	Norovirus	Norovirus	NNP
cord-302047-vv5gpldi	516	38	-	-	HYPH
cord-302047-vv5gpldi	516	39	Similar	Similar	NNP
cord-302047-vv5gpldi	516	40	Replication	Replication	NNP
cord-302047-vv5gpldi	516	41	Kinetics	Kinetics	NNP
cord-302047-vv5gpldi	516	42	in	in	IN
cord-302047-vv5gpldi	516	43	Cell	cell	NN
cord-302047-vv5gpldi	516	44	Culture	culture	NN
cord-302047-vv5gpldi	517	1	But	but	CC
cord-302047-vv5gpldi	517	2	Attenuation	attenuation	NN
cord-302047-vv5gpldi	517	3	of	of	IN
cord-302047-vv5gpldi	517	4	Viral	Viral	NNP
cord-302047-vv5gpldi	517	5	Fitness	Fitness	NNP
cord-302047-vv5gpldi	517	6	In	in	IN
cord-302047-vv5gpldi	517	7	Vivo	Vivo	NNP
cord-302047-vv5gpldi	517	8	Highly	highly	RB
cord-302047-vv5gpldi	517	9	Stable	stable	JJ
cord-302047-vv5gpldi	517	10	Expression	expression	NN
cord-302047-vv5gpldi	517	11	of	of	IN
cord-302047-vv5gpldi	517	12	a	a	DT
cord-302047-vv5gpldi	517	13	Foreign	Foreign	NNP
cord-302047-vv5gpldi	517	14	Gene	Gene	NNP
cord-302047-vv5gpldi	517	15	from	from	IN
cord-302047-vv5gpldi	517	16	Rabies	Rabies	NNP
cord-302047-vv5gpldi	517	17	Virus	Virus	NNP
cord-302047-vv5gpldi	517	18	Vectors	Vectors	NNP
cord-302047-vv5gpldi	517	19	Clinical	clinical	JJ
cord-302047-vv5gpldi	517	20	Use	Use	NNP
cord-302047-vv5gpldi	517	21	of	of	IN
cord-302047-vv5gpldi	517	22	Lentiviral	Lentiviral	NNP
cord-302047-vv5gpldi	517	23	Vectors	Vectors	NNP
cord-302047-vv5gpldi	517	24	Estimation	Estimation	NNP
cord-302047-vv5gpldi	517	25	of	of	IN
cord-302047-vv5gpldi	517	26	the	the	DT
cord-302047-vv5gpldi	517	27	Size	Size	NNP
cord-302047-vv5gpldi	517	28	of	of	IN
cord-302047-vv5gpldi	517	29	Genetic	genetic	JJ
cord-302047-vv5gpldi	517	30	Bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	517	31	in	in	IN
cord-302047-vv5gpldi	517	32	Cell	cell	NN
cord-302047-vv5gpldi	517	33	-	-	HYPH
cord-302047-vv5gpldi	517	34	to	to	IN
cord-302047-vv5gpldi	517	35	-	-	HYPH
cord-302047-vv5gpldi	517	36	cell	cell	NN
cord-302047-vv5gpldi	517	37	Movement	Movement	NNP
cord-302047-vv5gpldi	517	38	of	of	IN
cord-302047-vv5gpldi	517	39	Soil	Soil	NNP
cord-302047-vv5gpldi	517	40	-	-	HYPH
cord-302047-vv5gpldi	517	41	borne	bear	VBN
cord-302047-vv5gpldi	517	42	Wheat	Wheat	NNP
cord-302047-vv5gpldi	517	43	Mosaic	Mosaic	NNP
cord-302047-vv5gpldi	517	44	Virus	Virus	NNP
cord-302047-vv5gpldi	517	45	and	and	CC
cord-302047-vv5gpldi	517	46	the	the	DT
cord-302047-vv5gpldi	517	47	Possible	possible	JJ
cord-302047-vv5gpldi	517	48	Role	role	NN
cord-302047-vv5gpldi	517	49	of	of	IN
cord-302047-vv5gpldi	517	50	the	the	DT
cord-302047-vv5gpldi	517	51	Bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	517	52	in	in	IN
cord-302047-vv5gpldi	517	53	Speeding	Speeding	NNP
cord-302047-vv5gpldi	517	54	Up	up	RP
cord-302047-vv5gpldi	517	55	Selection	Selection	NNP
cord-302047-vv5gpldi	517	56	of	of	IN
cord-302047-vv5gpldi	517	57	Variations	Variations	NNPS
cord-302047-vv5gpldi	517	58	in	in	IN
cord-302047-vv5gpldi	517	59	Trans	Trans	NNP
cord-302047-vv5gpldi	517	60	-	-	NNP
cord-302047-vv5gpldi	517	61	acting	act	VBG
cord-302047-vv5gpldi	517	62	Genes	Genes	NNPS
cord-302047-vv5gpldi	517	63	or	or	CC
cord-302047-vv5gpldi	517	64	Elements	Elements	NNPS
cord-302047-vv5gpldi	517	65	Instability	Instability	NNP
cord-302047-vv5gpldi	517	66	and	and	CC
cord-302047-vv5gpldi	517	67	Reiteration	reiteration	NN
cord-302047-vv5gpldi	517	68	of	of	IN
cord-302047-vv5gpldi	517	69	DNA	dna	NN
cord-302047-vv5gpldi	517	70	Sequences	sequence	NNS
cord-302047-vv5gpldi	517	71	Within	within	IN
cord-302047-vv5gpldi	517	72	the	the	DT
cord-302047-vv5gpldi	517	73	Vaccinia	Vaccinia	NNP
cord-302047-vv5gpldi	517	74	Virus	Virus	NNP
cord-302047-vv5gpldi	517	75	Genome	Genome	NNP
cord-302047-vv5gpldi	518	1	The	the	DT
cord-302047-vv5gpldi	518	2	V4	V4	NNP
cord-302047-vv5gpldi	518	3	and	and	CC
cord-302047-vv5gpldi	518	4	V5	v5	NN
cord-302047-vv5gpldi	518	5	Variable	variable	JJ
cord-302047-vv5gpldi	518	6	Loops	Loops	NNP
cord-302047-vv5gpldi	518	7	of	of	IN
cord-302047-vv5gpldi	518	8	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	518	9	Envelope	Envelope	NNP
cord-302047-vv5gpldi	518	10	Glycoprotein	Glycoprotein	NNP
cord-302047-vv5gpldi	518	11	are	be	VBP
cord-302047-vv5gpldi	518	12	Tolerant	tolerant	JJ
cord-302047-vv5gpldi	518	13	to	to	IN
cord-302047-vv5gpldi	518	14	Insertion	Insertion	NNP
cord-302047-vv5gpldi	518	15	of	of	IN
cord-302047-vv5gpldi	518	16	Green	Green	NNP
cord-302047-vv5gpldi	518	17	Fluorescent	Fluorescent	NNP
cord-302047-vv5gpldi	518	18	Protein	Protein	NNP
cord-302047-vv5gpldi	518	19	and	and	CC
cord-302047-vv5gpldi	518	20	are	be	VBP
cord-302047-vv5gpldi	518	21	Useful	useful	JJ
cord-302047-vv5gpldi	518	22	Targets	target	NNS
cord-302047-vv5gpldi	518	23	for	for	IN
cord-302047-vv5gpldi	518	24	Labeling	label	VBG
cord-302047-vv5gpldi	518	25	Effects	effect	NNS
cord-302047-vv5gpldi	518	26	of	of	IN
cord-302047-vv5gpldi	518	27	Viral	Viral	NNP
cord-302047-vv5gpldi	518	28	Strain	Strain	NNP
cord-302047-vv5gpldi	518	29	,	,	,
cord-302047-vv5gpldi	518	30	Transgene	Transgene	NNP
cord-302047-vv5gpldi	518	31	Position	Position	NNP
cord-302047-vv5gpldi	518	32	,	,	,
cord-302047-vv5gpldi	518	33	and	and	CC
cord-302047-vv5gpldi	518	34	Target	Target	NNP
cord-302047-vv5gpldi	518	35	Cell	Cell	NNP
cord-302047-vv5gpldi	518	36	Type	type	NN
cord-302047-vv5gpldi	518	37	on	on	IN
cord-302047-vv5gpldi	518	38	Replication	Replication	NNP
cord-302047-vv5gpldi	518	39	Kinetics	Kinetics	NNP
cord-302047-vv5gpldi	518	40	,	,	,
cord-302047-vv5gpldi	518	41	Genomic	Genomic	NNP
cord-302047-vv5gpldi	518	42	Stability	Stability	NNP
cord-302047-vv5gpldi	518	43	,	,	,
cord-302047-vv5gpldi	518	44	and	and	CC
cord-302047-vv5gpldi	518	45	Transgene	transgene	JJ
cord-302047-vv5gpldi	518	46	Expression	expression	NN
cord-302047-vv5gpldi	518	47	of	of	IN
cord-302047-vv5gpldi	518	48	Replication	replication	NN
cord-302047-vv5gpldi	518	49	-	-	HYPH
cord-302047-vv5gpldi	518	50	competent	competent	JJ
cord-302047-vv5gpldi	518	51	Murine	Murine	NNP
cord-302047-vv5gpldi	518	52	Leukemia	Leukemia	NNP
cord-302047-vv5gpldi	518	53	Virus	Virus	NNP
cord-302047-vv5gpldi	518	54	-	-	HYPH
cord-302047-vv5gpldi	518	55	based	base	VBN
cord-302047-vv5gpldi	518	56	Vectors	Vectors	NNP
cord-302047-vv5gpldi	518	57	Phylogenetic	Phylogenetic	NNP
cord-302047-vv5gpldi	518	58	Measures	Measures	NNPS
cord-302047-vv5gpldi	518	59	of	of	IN
cord-302047-vv5gpldi	518	60	Indel	Indel	NNP
cord-302047-vv5gpldi	518	61	Rate	Rate	NNP
cord-302047-vv5gpldi	518	62	Variation	variation	NN
cord-302047-vv5gpldi	518	63	among	among	IN
cord-302047-vv5gpldi	518	64	the	the	DT
cord-302047-vv5gpldi	518	65	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	518	66	Group	Group	NNP
cord-302047-vv5gpldi	518	67	M	M	NNP
cord-302047-vv5gpldi	518	68	Subtypes	Subtypes	NNPS
cord-302047-vv5gpldi	518	69	Deletion	Deletion	NNP
cord-302047-vv5gpldi	518	70	and	and	CC
cord-302047-vv5gpldi	518	71	Recombination	recombination	NN
cord-302047-vv5gpldi	518	72	Events	event	NNS
cord-302047-vv5gpldi	518	73	Between	between	IN
cord-302047-vv5gpldi	518	74	the	the	DT
cord-302047-vv5gpldi	518	75	DNA	dna	NN
cord-302047-vv5gpldi	518	76	-	-	HYPH
cord-302047-vv5gpldi	518	77	A	a	NN
cord-302047-vv5gpldi	518	78	and	and	CC
cord-302047-vv5gpldi	518	79	DNA	dna	NN
cord-302047-vv5gpldi	518	80	-	-	HYPH
cord-302047-vv5gpldi	518	81	B	B	NNP
cord-302047-vv5gpldi	518	82	Components	Components	NNP
cord-302047-vv5gpldi	518	83	of	of	IN
cord-302047-vv5gpldi	518	84	Indian	indian	JJ
cord-302047-vv5gpldi	518	85	Cassava	Cassava	NNP
cord-302047-vv5gpldi	518	86	-	-	HYPH
cord-302047-vv5gpldi	518	87	infecting	infect	VBG
cord-302047-vv5gpldi	518	88	Geminiviruses	Geminiviruses	NNP
cord-302047-vv5gpldi	518	89	Generate	generate	VBP
cord-302047-vv5gpldi	518	90	Defective	defective	JJ
cord-302047-vv5gpldi	518	91	Molecules	Molecules	NNPS
cord-302047-vv5gpldi	518	92	in	in	IN
cord-302047-vv5gpldi	518	93	Nicotiana	Nicotiana	NNP
cord-302047-vv5gpldi	518	94	benthamiana	benthamiana	NNP
cord-302047-vv5gpldi	518	95	Generation	Generation	NNP
cord-302047-vv5gpldi	518	96	of	of	IN
cord-302047-vv5gpldi	518	97	Recombinant	Recombinant	NNP
cord-302047-vv5gpldi	518	98	Rotavirus	Rotavirus	NNP
cord-302047-vv5gpldi	519	1	Expressing	express	VBG
cord-302047-vv5gpldi	519	2	NSP3-UnaG	NSP3-UnaG	NNP
cord-302047-vv5gpldi	519	3	Fusion	Fusion	NNP
cord-302047-vv5gpldi	519	4	Protein	Protein	NNP
cord-302047-vv5gpldi	519	5	by	by	IN
cord-302047-vv5gpldi	519	6	a	a	DT
cord-302047-vv5gpldi	519	7	Simplified	Simplified	NNP
cord-302047-vv5gpldi	519	8	Reverse	Reverse	NNP
cord-302047-vv5gpldi	519	9	Genetics	Genetics	NNP
cord-302047-vv5gpldi	519	10	System	system	NN
cord-302047-vv5gpldi	520	1	An	an	DT
cord-302047-vv5gpldi	520	2	Infectious	Infectious	NNP
cord-302047-vv5gpldi	520	3	West	West	NNP
cord-302047-vv5gpldi	520	4	Nile	Nile	NNP
cord-302047-vv5gpldi	520	5	Virus	Virus	NNP
cord-302047-vv5gpldi	520	6	That	that	WDT
cord-302047-vv5gpldi	520	7	Expresses	express	VBZ
cord-302047-vv5gpldi	520	8	a	a	DT
cord-302047-vv5gpldi	520	9	GFP	GFP	NNP
cord-302047-vv5gpldi	520	10	Reporter	reporter	NN
cord-302047-vv5gpldi	520	11	Gene	Gene	NNP
cord-302047-vv5gpldi	520	12	Spontaneous	spontaneous	JJ
cord-302047-vv5gpldi	520	13	Excision	excision	NN
cord-302047-vv5gpldi	520	14	of	of	IN
cord-302047-vv5gpldi	520	15	BAC	BAC	NNP
cord-302047-vv5gpldi	520	16	Vector	Vector	NNP
cord-302047-vv5gpldi	520	17	Sequences	Sequences	NNPS
cord-302047-vv5gpldi	520	18	from	from	IN
cord-302047-vv5gpldi	520	19	Bacmid	Bacmid	NNP
cord-302047-vv5gpldi	520	20	-	-	HYPH
cord-302047-vv5gpldi	520	21	derived	derive	VBN
cord-302047-vv5gpldi	520	22	Baculovirus	Baculovirus	NNP
cord-302047-vv5gpldi	520	23	Expression	Expression	NNP
cord-302047-vv5gpldi	520	24	Vectors	Vectors	NNPS
cord-302047-vv5gpldi	520	25	upon	upon	IN
cord-302047-vv5gpldi	520	26	Passage	passage	NN
cord-302047-vv5gpldi	520	27	in	in	IN
cord-302047-vv5gpldi	520	28	Insect	Insect	NNP
cord-302047-vv5gpldi	520	29	Cells	cell	NNS
cord-302047-vv5gpldi	521	1	Double	double	JJ
cord-302047-vv5gpldi	521	2	-	-	HYPH
cord-302047-vv5gpldi	521	3	subgenomic	subgenomic	JJ
cord-302047-vv5gpldi	521	4	Sindbis	Sindbis	NNP
cord-302047-vv5gpldi	521	5	Virus	Virus	NNP
cord-302047-vv5gpldi	521	6	Recombinants	recombinant	NNS
cord-302047-vv5gpldi	521	7	Expressing	express	VBG
cord-302047-vv5gpldi	521	8	Immunogenic	immunogenic	JJ
cord-302047-vv5gpldi	521	9	Proteins	protein	NNS
cord-302047-vv5gpldi	521	10	of	of	IN
cord-302047-vv5gpldi	521	11	Japanese	japanese	JJ
cord-302047-vv5gpldi	521	12	Encephalitis	Encephalitis	NNP
cord-302047-vv5gpldi	521	13	Virus	virus	NN
cord-302047-vv5gpldi	522	1	Induce	induce	VB
cord-302047-vv5gpldi	522	2	Significant	Significant	NNP
cord-302047-vv5gpldi	522	3	Protection	Protection	NNP
cord-302047-vv5gpldi	522	4	in	in	IN
cord-302047-vv5gpldi	522	5	Mice	Mice	NNP
cord-302047-vv5gpldi	522	6	Against	against	IN
cord-302047-vv5gpldi	522	7	Lethal	Lethal	NNP
cord-302047-vv5gpldi	522	8	JEV	JEV	NNP
cord-302047-vv5gpldi	522	9	Infection	Infection	NNP
cord-302047-vv5gpldi	522	10	Assessment	Assessment	NNP
cord-302047-vv5gpldi	522	11	of	of	IN
cord-302047-vv5gpldi	522	12	Recombinants	Recombinants	NNPS
cord-302047-vv5gpldi	522	13	That	that	WDT
cord-302047-vv5gpldi	522	14	Arise	arise	VBP
cord-302047-vv5gpldi	522	15	from	from	IN
cord-302047-vv5gpldi	522	16	the	the	DT
cord-302047-vv5gpldi	522	17	Use	Use	NNP
cord-302047-vv5gpldi	522	18	of	of	IN
cord-302047-vv5gpldi	522	19	a	a	DT
cord-302047-vv5gpldi	522	20	TMV	TMV	NNP
cord-302047-vv5gpldi	522	21	-	-	HYPH
cord-302047-vv5gpldi	522	22	based	base	VBN
cord-302047-vv5gpldi	522	23	Transient	transient	JJ
cord-302047-vv5gpldi	522	24	Expression	expression	NN
cord-302047-vv5gpldi	522	25	Vector	vector	NN
cord-302047-vv5gpldi	522	26	Clinical	Clinical	NNP
cord-302047-vv5gpldi	522	27	Trials	Trials	NNPS
cord-302047-vv5gpldi	522	28	with	with	IN
cord-302047-vv5gpldi	522	29	Retrovirus	Retrovirus	NNP
cord-302047-vv5gpldi	522	30	Mediated	mediate	VBN
cord-302047-vv5gpldi	522	31	Gene	Gene	NNP
cord-302047-vv5gpldi	522	32	Therapy	Therapy	NNP
cord-302047-vv5gpldi	523	1	:	:	:
cord-302047-vv5gpldi	523	2	What	what	WP
cord-302047-vv5gpldi	523	3	Have	have	VBP
cord-302047-vv5gpldi	523	4	we	-PRON-	PRP
cord-302047-vv5gpldi	523	5	Learned	learn	VBN
cord-302047-vv5gpldi	523	6	?	?	.
cord-302047-vv5gpldi	524	1	A	a	DT
cord-302047-vv5gpldi	524	2	Novel	Novel	NNP
cord-302047-vv5gpldi	524	3	Genotype	Genotype	NNP
cord-302047-vv5gpldi	524	4	Encoding	Encoding	NNP
cord-302047-vv5gpldi	524	5	a	a	DT
cord-302047-vv5gpldi	524	6	Single	Single	NNP
cord-302047-vv5gpldi	524	7	Amino	amino	NN
cord-302047-vv5gpldi	524	8	Acid	acid	NN
cord-302047-vv5gpldi	524	9	Insertion	insertion	NN
cord-302047-vv5gpldi	524	10	and	and	CC
cord-302047-vv5gpldi	524	11	Five	five	CD
cord-302047-vv5gpldi	524	12	Other	other	JJ
cord-302047-vv5gpldi	524	13	Substitutions	substitution	NNS
cord-302047-vv5gpldi	525	1	Between	between	IN
cord-302047-vv5gpldi	525	2	Residues	Residues	NNP
cord-302047-vv5gpldi	525	3	64	64	CD
cord-302047-vv5gpldi	525	4	and	and	CC
cord-302047-vv5gpldi	525	5	74	74	CD
cord-302047-vv5gpldi	525	6	of	of	IN
cord-302047-vv5gpldi	525	7	the	the	DT
cord-302047-vv5gpldi	525	8	HIV-1	HIV-1	NNP
cord-302047-vv5gpldi	525	9	Reverse	Reverse	NNP
cord-302047-vv5gpldi	525	10	Transcriptase	Transcriptase	NNP
cord-302047-vv5gpldi	526	1	Confers	confer	VBZ
cord-302047-vv5gpldi	526	2	High	high	JJ
cord-302047-vv5gpldi	526	3	-	-	HYPH
cord-302047-vv5gpldi	526	4	level	level	NN
cord-302047-vv5gpldi	526	5	Cross	Cross	NNP
cord-302047-vv5gpldi	526	6	-	-	NN
cord-302047-vv5gpldi	526	7	resistance	resistance	NN
cord-302047-vv5gpldi	526	8	to	to	IN
cord-302047-vv5gpldi	526	9	Nucleoside	Nucleoside	NNP
cord-302047-vv5gpldi	526	10	Reverse	Reverse	NNP
cord-302047-vv5gpldi	526	11	Transcriptase	Transcriptase	NNP
cord-302047-vv5gpldi	526	12	Inhibitors	Inhibitors	NNP
cord-302047-vv5gpldi	526	13	Generation	Generation	NNP
cord-302047-vv5gpldi	526	14	of	of	IN
cord-302047-vv5gpldi	526	15	Infectious	Infectious	NNP
cord-302047-vv5gpldi	526	16	Clone	Clone	NNP
cord-302047-vv5gpldi	526	17	of	of	IN
cord-302047-vv5gpldi	526	18	Bovine	Bovine	NNP
cord-302047-vv5gpldi	526	19	Adenovirus	Adenovirus	NNP
cord-302047-vv5gpldi	526	20	Type	Type	NNP
cord-302047-vv5gpldi	527	1	I	-PRON-	PRP
cord-302047-vv5gpldi	527	2	Expressing	express	VBG
cord-302047-vv5gpldi	527	3	a	a	DT
cord-302047-vv5gpldi	527	4	Visible	visible	JJ
cord-302047-vv5gpldi	527	5	Marker	Marker	NNP
cord-302047-vv5gpldi	527	6	Gene	Gene	NNP
cord-302047-vv5gpldi	527	7	Complete	Complete	NNP
cord-302047-vv5gpldi	527	8	Protection	Protection	NNP
cord-302047-vv5gpldi	527	9	from	from	IN
cord-302047-vv5gpldi	527	10	Papillomavirus	Papillomavirus	NNP
cord-302047-vv5gpldi	527	11	Challenge	Challenge	NNP
cord-302047-vv5gpldi	527	12	After	after	IN
cord-302047-vv5gpldi	527	13	a	a	DT
cord-302047-vv5gpldi	527	14	Single	single	JJ
cord-302047-vv5gpldi	527	15	Vaccination	vaccination	NN
cord-302047-vv5gpldi	527	16	with	with	IN
cord-302047-vv5gpldi	527	17	a	a	DT
cord-302047-vv5gpldi	527	18	Vesicular	Vesicular	NNP
cord-302047-vv5gpldi	527	19	Stomatitis	Stomatitis	NNP
cord-302047-vv5gpldi	527	20	Virus	virus	NN
cord-302047-vv5gpldi	527	21	Vector	vector	NN
cord-302047-vv5gpldi	527	22	Expressing	express	VBG
cord-302047-vv5gpldi	527	23	High	High	NNP
cord-302047-vv5gpldi	527	24	Levels	level	NNS
cord-302047-vv5gpldi	527	25	of	of	IN
cord-302047-vv5gpldi	527	26	L1	L1	NNP
cord-302047-vv5gpldi	527	27	Protein	Protein	NNP
cord-302047-vv5gpldi	527	28	Functional	Functional	NNP
cord-302047-vv5gpldi	527	29	cDNA	cdna	NN
cord-302047-vv5gpldi	527	30	Clones	Clones	NNPS
cord-302047-vv5gpldi	527	31	of	of	IN
cord-302047-vv5gpldi	527	32	the	the	DT
cord-302047-vv5gpldi	527	33	Flaviviridae	Flaviviridae	NNP
cord-302047-vv5gpldi	527	34	:	:	:
cord-302047-vv5gpldi	527	35	Strategies	Strategies	NNP
cord-302047-vv5gpldi	527	36	and	and	CC
cord-302047-vv5gpldi	527	37	Applications	Applications	NNPS
cord-302047-vv5gpldi	527	38	Construction	Construction	NNP
cord-302047-vv5gpldi	527	39	of	of	IN
cord-302047-vv5gpldi	527	40	Bacteriophage	Bacteriophage	NNP
cord-302047-vv5gpldi	527	41	phiX174	phiX174	NNP
cord-302047-vv5gpldi	527	42	Mutants	mutant	NNS
cord-302047-vv5gpldi	527	43	with	with	IN
cord-302047-vv5gpldi	527	44	Maximum	Maximum	NNP
cord-302047-vv5gpldi	527	45	Genome	Genome	NNP
cord-302047-vv5gpldi	527	46	Sizes	Sizes	NNPS
cord-302047-vv5gpldi	527	47	Properties	Properties	NNPS
cord-302047-vv5gpldi	527	48	and	and	CC
cord-302047-vv5gpldi	527	49	Behavior	Behavior	NNP
cord-302047-vv5gpldi	527	50	of	of	IN
cord-302047-vv5gpldi	527	51	Orally	orally	RB
cord-302047-vv5gpldi	527	52	Administered	Administered	NNP
cord-302047-vv5gpldi	527	53	Attenuated	Attenuated	NNP
cord-302047-vv5gpldi	527	54	Poliovirus	Poliovirus	NNP
cord-302047-vv5gpldi	527	55	Vaccine	Vaccine	NNP
cord-302047-vv5gpldi	527	56	Accommodation	Accommodation	NNP
cord-302047-vv5gpldi	527	57	of	of	IN
cord-302047-vv5gpldi	527	58	Foreign	Foreign	NNP
cord-302047-vv5gpldi	527	59	Genes	Genes	NNPS
cord-302047-vv5gpldi	527	60	into	into	IN
cord-302047-vv5gpldi	527	61	the	the	DT
cord-302047-vv5gpldi	527	62	Sendai	Sendai	NNP
cord-302047-vv5gpldi	527	63	Virus	Virus	NNP
cord-302047-vv5gpldi	527	64	Genome	Genome	NNP
cord-302047-vv5gpldi	527	65	:	:	:
cord-302047-vv5gpldi	527	66	Sizes	size	NNS
cord-302047-vv5gpldi	527	67	of	of	IN
cord-302047-vv5gpldi	527	68	Inserted	Inserted	NNP
cord-302047-vv5gpldi	527	69	Genes	Genes	NNPS
cord-302047-vv5gpldi	527	70	and	and	CC
cord-302047-vv5gpldi	527	71	Viral	Viral	NNP
cord-302047-vv5gpldi	527	72	Replication	Replication	NNP
cord-302047-vv5gpldi	527	73	The	the	DT
cord-302047-vv5gpldi	527	74	Distribution	Distribution	NNP
cord-302047-vv5gpldi	527	75	of	of	IN
cord-302047-vv5gpldi	527	76	Fitness	Fitness	NNP
cord-302047-vv5gpldi	527	77	Effects	effect	NNS
cord-302047-vv5gpldi	527	78	Caused	cause	VBN
cord-302047-vv5gpldi	527	79	by	by	IN
cord-302047-vv5gpldi	527	80	Single	single	JJ
cord-302047-vv5gpldi	527	81	-	-	HYPH
cord-302047-vv5gpldi	527	82	nucleotide	nucleotide	JJ
cord-302047-vv5gpldi	527	83	Substitutions	substitution	NNS
cord-302047-vv5gpldi	527	84	in	in	IN
cord-302047-vv5gpldi	527	85	an	an	DT
cord-302047-vv5gpldi	527	86	RNA	RNA	NNP
cord-302047-vv5gpldi	527	87	Virus	virus	NN
cord-302047-vv5gpldi	527	88	Challenges	challenge	VBZ
cord-302047-vv5gpldi	527	89	in	in	IN
cord-302047-vv5gpldi	527	90	Predicting	predict	VBG
cord-302047-vv5gpldi	527	91	the	the	DT
cord-302047-vv5gpldi	527	92	Evolutionary	Evolutionary	NNP
cord-302047-vv5gpldi	527	93	Maintenance	Maintenance	NNP
cord-302047-vv5gpldi	527	94	of	of	IN
cord-302047-vv5gpldi	527	95	a	a	DT
cord-302047-vv5gpldi	527	96	Phage	Phage	NNP
cord-302047-vv5gpldi	527	97	Transgene	transgene	NN
cord-302047-vv5gpldi	528	1	The	the	DT
cord-302047-vv5gpldi	528	2	Minimal	Minimal	NNP
cord-302047-vv5gpldi	528	3	Conserved	Conserved	NNP
cord-302047-vv5gpldi	528	4	Transcription	Transcription	NNP
cord-302047-vv5gpldi	528	5	Stop	stop	NN
cord-302047-vv5gpldi	528	6	-	-	HYPH
cord-302047-vv5gpldi	528	7	start	start	NN
cord-302047-vv5gpldi	528	8	Signal	signal	NN
cord-302047-vv5gpldi	528	9	Promotes	promote	VBZ
cord-302047-vv5gpldi	528	10	Stable	stable	JJ
cord-302047-vv5gpldi	528	11	Expression	expression	NN
cord-302047-vv5gpldi	528	12	of	of	IN
cord-302047-vv5gpldi	528	13	a	a	DT
cord-302047-vv5gpldi	528	14	Foreign	Foreign	NNP
cord-302047-vv5gpldi	528	15	Gene	Gene	NNP
cord-302047-vv5gpldi	528	16	in	in	IN
cord-302047-vv5gpldi	528	17	Vesicular	Vesicular	NNP
cord-302047-vv5gpldi	528	18	Stomatitis	Stomatitis	NNP
cord-302047-vv5gpldi	528	19	Virus	Virus	NNP
cord-302047-vv5gpldi	528	20	Plant	Plant	NNP
cord-302047-vv5gpldi	528	21	Virus	Virus	NNP
cord-302047-vv5gpldi	528	22	Gene	Gene	NNP
cord-302047-vv5gpldi	528	23	Vectors	Vectors	NNP
cord-302047-vv5gpldi	528	24	for	for	IN
cord-302047-vv5gpldi	528	25	Transient	transient	JJ
cord-302047-vv5gpldi	528	26	Expression	expression	NN
cord-302047-vv5gpldi	528	27	of	of	IN
cord-302047-vv5gpldi	528	28	Foreign	Foreign	NNP
cord-302047-vv5gpldi	528	29	Proteins	Proteins	NNPS
cord-302047-vv5gpldi	528	30	in	in	IN
cord-302047-vv5gpldi	528	31	Plants	Plants	NNP
cord-302047-vv5gpldi	528	32	Integration	Integration	NNP
cord-302047-vv5gpldi	528	33	of	of	IN
cord-302047-vv5gpldi	528	34	Hepatitis	Hepatitis	NNP
cord-302047-vv5gpldi	528	35	B	B	NNP
cord-302047-vv5gpldi	528	36	Virus	Virus	NNP
cord-302047-vv5gpldi	528	37	DNA	DNA	NNP
cord-302047-vv5gpldi	528	38	into	into	IN
cord-302047-vv5gpldi	528	39	the	the	DT
cord-302047-vv5gpldi	528	40	Genome	Genome	NNP
cord-302047-vv5gpldi	528	41	of	of	IN
cord-302047-vv5gpldi	528	42	Liver	Liver	NNP
cord-302047-vv5gpldi	528	43	Cells	Cells	NNPS
cord-302047-vv5gpldi	528	44	in	in	IN
cord-302047-vv5gpldi	528	45	Chronic	Chronic	NNP
cord-302047-vv5gpldi	528	46	Liver	Liver	NNP
cord-302047-vv5gpldi	528	47	Disease	Disease	NNP
cord-302047-vv5gpldi	528	48	and	and	CC
cord-302047-vv5gpldi	529	1	Hepatocellular	Hepatocellular	NNP
cord-302047-vv5gpldi	529	2	Carcinoma	Carcinoma	NNP
cord-302047-vv5gpldi	529	3	Mutational	Mutational	NNP
cord-302047-vv5gpldi	529	4	Analysis	Analysis	NNP
cord-302047-vv5gpldi	529	5	of	of	IN
cord-302047-vv5gpldi	529	6	the	the	DT
cord-302047-vv5gpldi	529	7	Small	Small	NNP
cord-302047-vv5gpldi	529	8	Intergenic	Intergenic	NNP
cord-302047-vv5gpldi	529	9	Region	Region	NNP
cord-302047-vv5gpldi	529	10	of	of	IN
cord-302047-vv5gpldi	529	11	Maize	Maize	NNP
cord-302047-vv5gpldi	529	12	Streak	Streak	NNP
cord-302047-vv5gpldi	529	13	Virus	Virus	NNP
cord-302047-vv5gpldi	530	1	The	the	DT
cord-302047-vv5gpldi	530	2	Effect	Effect	NNP
cord-302047-vv5gpldi	530	3	of	of	IN
cord-302047-vv5gpldi	530	4	Gene	Gene	NNP
cord-302047-vv5gpldi	530	5	Overlapping	Overlapping	NNP
cord-302047-vv5gpldi	530	6	on	on	IN
cord-302047-vv5gpldi	530	7	the	the	DT
cord-302047-vv5gpldi	530	8	Rate	Rate	NNP
cord-302047-vv5gpldi	530	9	of	of	IN
cord-302047-vv5gpldi	530	10	RNA	RNA	NNP
cord-302047-vv5gpldi	530	11	Virus	Virus	NNP
cord-302047-vv5gpldi	530	12	Evolution	Evolution	NNP
cord-302047-vv5gpldi	530	13	Long	Long	NNP
cord-302047-vv5gpldi	530	14	Nucleotide	Nucleotide	NNP
cord-302047-vv5gpldi	530	15	Insertions	Insertions	NNPS
cord-302047-vv5gpldi	530	16	Between	between	IN
cord-302047-vv5gpldi	530	17	the	the	DT
cord-302047-vv5gpldi	530	18	HN	HN	NNP
cord-302047-vv5gpldi	530	19	and	and	CC
cord-302047-vv5gpldi	530	20	L	L	NNP
cord-302047-vv5gpldi	530	21	Protein	Protein	NNP
cord-302047-vv5gpldi	530	22	Coding	Coding	NNP
cord-302047-vv5gpldi	530	23	Regions	Regions	NNPS
cord-302047-vv5gpldi	530	24	of	of	IN
cord-302047-vv5gpldi	530	25	Human	Human	NNP
cord-302047-vv5gpldi	530	26	Parainfluenza	Parainfluenza	NNP
cord-302047-vv5gpldi	530	27	Virus	Virus	NNP
cord-302047-vv5gpldi	530	28	Type	Type	NNP
cord-302047-vv5gpldi	530	29	3	3	CD
cord-302047-vv5gpldi	530	30	Yield	yield	NN
cord-302047-vv5gpldi	530	31	Viruses	virus	NNS
cord-302047-vv5gpldi	530	32	with	with	IN
cord-302047-vv5gpldi	530	33	Temperature	temperature	NN
cord-302047-vv5gpldi	530	34	-	-	HYPH
cord-302047-vv5gpldi	530	35	sensitive	sensitive	JJ
cord-302047-vv5gpldi	530	36	and	and	CC
cord-302047-vv5gpldi	530	37	Attenuation	attenuation	NN
cord-302047-vv5gpldi	530	38	Phenotypes	Phenotypes	NNP
cord-302047-vv5gpldi	530	39	Construction	Construction	NNP
cord-302047-vv5gpldi	530	40	and	and	CC
cord-302047-vv5gpldi	530	41	Transposon	Transposon	NNP
cord-302047-vv5gpldi	530	42	Mutagenesis	Mutagenesis	NNP
cord-302047-vv5gpldi	530	43	in	in	IN
cord-302047-vv5gpldi	530	44	Escherichia	Escherichia	NNP
cord-302047-vv5gpldi	530	45	coli	coli	NNS
cord-302047-vv5gpldi	530	46	of	of	IN
cord-302047-vv5gpldi	530	47	a	a	DT
cord-302047-vv5gpldi	530	48	Full	full	JJ
cord-302047-vv5gpldi	530	49	-	-	HYPH
cord-302047-vv5gpldi	530	50	length	length	NN
cord-302047-vv5gpldi	530	51	Infectious	Infectious	NNP
cord-302047-vv5gpldi	530	52	Clone	Clone	NNP
cord-302047-vv5gpldi	530	53	of	of	IN
cord-302047-vv5gpldi	530	54	Pseudorabies	Pseudorabies	NNP
cord-302047-vv5gpldi	530	55	Virus	Virus	NNP
cord-302047-vv5gpldi	530	56	,	,	,
cord-302047-vv5gpldi	530	57	an	an	DT
cord-302047-vv5gpldi	530	58	Alphaherpesvirus	Alphaherpesvirus	NNP
cord-302047-vv5gpldi	530	59	Evolutionary	Evolutionary	NNP
cord-302047-vv5gpldi	530	60	Stability	Stability	NNP
cord-302047-vv5gpldi	530	61	of	of	IN
cord-302047-vv5gpldi	530	62	a	a	DT
cord-302047-vv5gpldi	530	63	Refactored	Refactored	NNP
cord-302047-vv5gpldi	530	64	Phage	Phage	NNP
cord-302047-vv5gpldi	530	65	Genome	Genome	NNP
cord-302047-vv5gpldi	530	66	Chimpanzee	Chimpanzee	NNP
cord-302047-vv5gpldi	530	67	Adenovirus	Adenovirus	NNP
cord-302047-vv5gpldi	530	68	Vaccine	Vaccine	NNP
cord-302047-vv5gpldi	530	69	Generates	generate	VBZ
cord-302047-vv5gpldi	530	70	Acute	acute	JJ
cord-302047-vv5gpldi	530	71	and	and	CC
cord-302047-vv5gpldi	530	72	Durable	durable	JJ
cord-302047-vv5gpldi	530	73	Protective	protective	JJ
cord-302047-vv5gpldi	530	74	Immunity	Immunity	NNP
cord-302047-vv5gpldi	530	75	Against	against	IN
cord-302047-vv5gpldi	530	76	Ebolavirus	Ebolavirus	NNP
cord-302047-vv5gpldi	530	77	Challenge	Challenge	NNP
cord-302047-vv5gpldi	530	78	Novel	Novel	NNP
cord-302047-vv5gpldi	530	79	Defective	defective	JJ
cord-302047-vv5gpldi	530	80	Interfering	Interfering	NNP
cord-302047-vv5gpldi	530	81	DNAs	dna	NNS
cord-302047-vv5gpldi	530	82	Associated	associate	VBN
cord-302047-vv5gpldi	530	83	with	with	IN
cord-302047-vv5gpldi	530	84	Ageratum	Ageratum	NNP
cord-302047-vv5gpldi	530	85	Yellow	Yellow	NNP
cord-302047-vv5gpldi	530	86	Vein	Vein	NNP
cord-302047-vv5gpldi	530	87	Geminivirus	Geminivirus	NNP
cord-302047-vv5gpldi	530	88	Infection	infection	NN
cord-302047-vv5gpldi	530	89	of	of	IN
cord-302047-vv5gpldi	530	90	Ageratum	Ageratum	NNP
cord-302047-vv5gpldi	531	1	conyzoides	conyzoides	NNP
cord-302047-vv5gpldi	532	1	A	a	DT
cord-302047-vv5gpldi	532	2	Number	Number	NNP
cord-302047-vv5gpldi	532	3	of	of	IN
cord-302047-vv5gpldi	532	4	Subgenomic	Subgenomic	NNP
cord-302047-vv5gpldi	532	5	DNAs	dna	NNS
cord-302047-vv5gpldi	532	6	are	be	VBP
cord-302047-vv5gpldi	532	7	Produced	produce	VBN
cord-302047-vv5gpldi	532	8	following	follow	VBG
cord-302047-vv5gpldi	532	9	Agroinoculation	Agroinoculation	NNP
cord-302047-vv5gpldi	532	10	of	of	IN
cord-302047-vv5gpldi	532	11	Plants	Plants	NNPS
cord-302047-vv5gpldi	532	12	with	with	IN
cord-302047-vv5gpldi	533	1	Beet	Beet	NNP
cord-302047-vv5gpldi	533	2	Curly	Curly	NNP
cord-302047-vv5gpldi	533	3	Top	Top	NNP
cord-302047-vv5gpldi	533	4	Virus	virus	NN
cord-302047-vv5gpldi	534	1	Mutational	Mutational	NNP
cord-302047-vv5gpldi	534	2	Biases	Biases	NNPS
cord-302047-vv5gpldi	535	1	Influence	influence	NN
cord-302047-vv5gpldi	535	2	Parallel	Parallel	NNP
cord-302047-vv5gpldi	535	3	Adaptation	Adaptation	NNP
cord-302047-vv5gpldi	535	4	Vaccinia	Vaccinia	NNP
cord-302047-vv5gpldi	535	5	Vectors	Vectors	NNP
cord-302047-vv5gpldi	535	6	as	as	IN
cord-302047-vv5gpldi	535	7	Candidate	Candidate	NNP
cord-302047-vv5gpldi	535	8	Vaccines	vaccine	NNS
cord-302047-vv5gpldi	535	9	:	:	:
cord-302047-vv5gpldi	536	1	The	the	DT
cord-302047-vv5gpldi	536	2	Development	Development	NNP
cord-302047-vv5gpldi	536	3	of	of	IN
cord-302047-vv5gpldi	536	4	Modified	Modified	NNP
cord-302047-vv5gpldi	536	5	Vaccinia	Vaccinia	NNP
cord-302047-vv5gpldi	536	6	Virus	Virus	NNP
cord-302047-vv5gpldi	536	7	Ankara	Ankara	NNP
cord-302047-vv5gpldi	536	8	for	for	IN
cord-302047-vv5gpldi	536	9	Antigen	Antigen	NNP
cord-302047-vv5gpldi	536	10	Delivery	Delivery	NNP
cord-302047-vv5gpldi	536	11	Expression	expression	NN
cord-302047-vv5gpldi	536	12	of	of	IN
cord-302047-vv5gpldi	536	13	Bacterial	Bacterial	NNP
cord-302047-vv5gpldi	536	14	Chloramphenicol	Chloramphenicol	NNP
cord-302047-vv5gpldi	536	15	Acetyltransferase	Acetyltransferase	NNP
cord-302047-vv5gpldi	536	16	Gene	Gene	NNP
cord-302047-vv5gpldi	536	17	in	in	IN
cord-302047-vv5gpldi	536	18	Tobacco	Tobacco	NNP
cord-302047-vv5gpldi	536	19	Plants	Plants	NNPS
cord-302047-vv5gpldi	536	20	Mediated	mediate	VBN
cord-302047-vv5gpldi	536	21	by	by	IN
cord-302047-vv5gpldi	536	22	TMV	TMV	NNP
cord-302047-vv5gpldi	536	23	-	-	HYPH
cord-302047-vv5gpldi	536	24	RNA	RNA	NNP
cord-302047-vv5gpldi	536	25	Characterization	characterization	NN
cord-302047-vv5gpldi	536	26	of	of	IN
cord-302047-vv5gpldi	536	27	Recombinant	Recombinant	NNP
cord-302047-vv5gpldi	536	28	Flaviviridae	Flaviviridae	NNP
cord-302047-vv5gpldi	536	29	Viruses	virus	NNS
cord-302047-vv5gpldi	536	30	Possessing	possess	VBG
cord-302047-vv5gpldi	536	31	a	a	DT
cord-302047-vv5gpldi	536	32	Small	small	JJ
cord-302047-vv5gpldi	536	33	Reporter	reporter	NN
cord-302047-vv5gpldi	536	34	Tag	tag	NN
cord-302047-vv5gpldi	536	35	Endogenous	endogenous	JJ
cord-302047-vv5gpldi	536	36	Viral	Viral	NNP
cord-302047-vv5gpldi	536	37	Sequences	Sequences	NNPS
cord-302047-vv5gpldi	536	38	in	in	IN
cord-302047-vv5gpldi	536	39	Plant	Plant	NNP
cord-302047-vv5gpldi	536	40	Genomes	Genomes	NNPS
cord-302047-vv5gpldi	536	41	Viable	viable	JJ
cord-302047-vv5gpldi	536	42	Molecular	molecular	JJ
cord-302047-vv5gpldi	536	43	Hybrids	hybrid	NNS
cord-302047-vv5gpldi	536	44	of	of	IN
cord-302047-vv5gpldi	536	45	Bacteriophage	Bacteriophage	NNP
cord-302047-vv5gpldi	536	46	Lambda	Lambda	NNP
cord-302047-vv5gpldi	536	47	and	and	CC
cord-302047-vv5gpldi	536	48	Eukaryotic	Eukaryotic	NNP
cord-302047-vv5gpldi	536	49	DNA	DNA	NNP
cord-302047-vv5gpldi	536	50	Recombinant	Recombinant	NNP
cord-302047-vv5gpldi	536	51	Sendai	Sendai	NNP
cord-302047-vv5gpldi	536	52	Viruses	virus	NNS
cord-302047-vv5gpldi	536	53	Expressing	express	VBG
cord-302047-vv5gpldi	536	54	Different	different	JJ
cord-302047-vv5gpldi	536	55	Levels	level	NNS
cord-302047-vv5gpldi	536	56	of	of	IN
cord-302047-vv5gpldi	536	57	a	a	DT
cord-302047-vv5gpldi	536	58	Foreign	Foreign	NNP
cord-302047-vv5gpldi	536	59	Reporter	reporter	NN
cord-302047-vv5gpldi	536	60	Gene	Gene	NNP
cord-302047-vv5gpldi	537	1	The	the	DT
cord-302047-vv5gpldi	537	2	Rate	Rate	NNP
cord-302047-vv5gpldi	537	3	and	and	CC
cord-302047-vv5gpldi	537	4	Spectrum	Spectrum	NNP
cord-302047-vv5gpldi	537	5	of	of	IN
cord-302047-vv5gpldi	537	6	Spontaneous	Spontaneous	NNP
cord-302047-vv5gpldi	537	7	Mutations	Mutations	NNPS
cord-302047-vv5gpldi	537	8	in	in	IN
cord-302047-vv5gpldi	537	9	a	a	DT
cord-302047-vv5gpldi	537	10	Plant	Plant	NNP
cord-302047-vv5gpldi	537	11	RNA	RNA	NNP
cord-302047-vv5gpldi	537	12	Virus	Virus	NNP
cord-302047-vv5gpldi	537	13	Rotavirus	Rotavirus	NNP
cord-302047-vv5gpldi	537	14	Rearranged	rearrange	VBD
cord-302047-vv5gpldi	537	15	Genomic	Genomic	NNP
cord-302047-vv5gpldi	537	16	RNA	RNA	NNP
cord-302047-vv5gpldi	537	17	Segments	Segments	NNPS
cord-302047-vv5gpldi	537	18	are	be	VBP
cord-302047-vv5gpldi	537	19	Preferentially	preferentially	RB
cord-302047-vv5gpldi	537	20	Packaged	package	VBN
cord-302047-vv5gpldi	537	21	into	into	IN
cord-302047-vv5gpldi	537	22	Viruses	virus	NNS
cord-302047-vv5gpldi	537	23	Despite	despite	IN
cord-302047-vv5gpldi	537	24	Not	not	RB
cord-302047-vv5gpldi	537	25	Conferring	confer	VBG
cord-302047-vv5gpldi	537	26	Selective	selective	JJ
cord-302047-vv5gpldi	537	27	Growth	growth	NN
cord-302047-vv5gpldi	537	28	Advantage	advantage	NN
cord-302047-vv5gpldi	537	29	to	to	IN
cord-302047-vv5gpldi	537	30	Viruses	Viruses	NNPS
cord-302047-vv5gpldi	537	31	Selection	Selection	NNP
cord-302047-vv5gpldi	537	32	of	of	IN
cord-302047-vv5gpldi	537	33	scFv	scFv	NNP
cord-302047-vv5gpldi	537	34	Phages	phage	NNS
cord-302047-vv5gpldi	537	35	on	on	IN
cord-302047-vv5gpldi	537	36	Intact	Intact	NNP
cord-302047-vv5gpldi	537	37	Cells	cell	NNS
cord-302047-vv5gpldi	537	38	Under	under	IN
cord-302047-vv5gpldi	537	39	Low	low	JJ
cord-302047-vv5gpldi	537	40	pH	ph	NN
cord-302047-vv5gpldi	537	41	Conditions	condition	NNS
cord-302047-vv5gpldi	538	1	Leads	lead	VBZ
cord-302047-vv5gpldi	538	2	to	to	IN
cord-302047-vv5gpldi	538	3	a	a	DT
cord-302047-vv5gpldi	538	4	Significant	significant	JJ
cord-302047-vv5gpldi	538	5	Loss	loss	NN
cord-302047-vv5gpldi	538	6	of	of	IN
cord-302047-vv5gpldi	538	7	Insert	insert	VB
cord-302047-vv5gpldi	538	8	-	-	HYPH
cord-302047-vv5gpldi	538	9	free	free	JJ
cord-302047-vv5gpldi	538	10	Phages	Phages	NNPS
cord-302047-vv5gpldi	538	11	Effects	Effects	NNPS
cord-302047-vv5gpldi	538	12	of	of	IN
cord-302047-vv5gpldi	538	13	Random	Random	NNP
cord-302047-vv5gpldi	538	14	Mutations	Mutations	NNPS
cord-302047-vv5gpldi	538	15	in	in	IN
cord-302047-vv5gpldi	538	16	the	the	DT
cord-302047-vv5gpldi	538	17	Human	Human	NNP
cord-302047-vv5gpldi	538	18	Immunodeficiency	Immunodeficiency	NNP
cord-302047-vv5gpldi	538	19	Virus	Virus	NNP
cord-302047-vv5gpldi	538	20	Type	Type	NNP
cord-302047-vv5gpldi	538	21	1	1	CD
cord-302047-vv5gpldi	538	22	Transcriptional	Transcriptional	NNP
cord-302047-vv5gpldi	538	23	Promoter	Promoter	NNP
cord-302047-vv5gpldi	538	24	on	on	IN
cord-302047-vv5gpldi	538	25	Viral	Viral	NNP
cord-302047-vv5gpldi	538	26	Fitness	Fitness	NNP
cord-302047-vv5gpldi	538	27	in	in	IN
cord-302047-vv5gpldi	538	28	Different	Different	NNP
cord-302047-vv5gpldi	538	29	Host	Host	NNP
cord-302047-vv5gpldi	538	30	Cell	cell	NN
cord-302047-vv5gpldi	538	31	Environments	environment	NNS
cord-302047-vv5gpldi	538	32	Expression	expression	NN
cord-302047-vv5gpldi	538	33	of	of	IN
cord-302047-vv5gpldi	538	34	a	a	DT
cord-302047-vv5gpldi	538	35	Bacterial	Bacterial	NNP
cord-302047-vv5gpldi	538	36	Gene	Gene	NNP
cord-302047-vv5gpldi	538	37	in	in	IN
cord-302047-vv5gpldi	538	38	Plants	plant	NNS
cord-302047-vv5gpldi	538	39	Mediated	mediate	VBN
cord-302047-vv5gpldi	538	40	by	by	IN
cord-302047-vv5gpldi	538	41	Infectious	Infectious	NNP
cord-302047-vv5gpldi	538	42	Geminivirus	Geminivirus	NNP
cord-302047-vv5gpldi	538	43	DNA	DNA	NNP
cord-302047-vv5gpldi	539	1	Adding	add	VBG
cord-302047-vv5gpldi	539	2	Genes	gene	NNS
cord-302047-vv5gpldi	539	3	to	to	IN
cord-302047-vv5gpldi	539	4	the	the	DT
cord-302047-vv5gpldi	539	5	RNA	RNA	NNP
cord-302047-vv5gpldi	539	6	Genome	Genome	NNP
cord-302047-vv5gpldi	539	7	of	of	IN
cord-302047-vv5gpldi	539	8	Vesicular	Vesicular	NNP
cord-302047-vv5gpldi	539	9	Stomatitis	Stomatitis	NNP
cord-302047-vv5gpldi	539	10	Virus	Virus	NNP
cord-302047-vv5gpldi	539	11	:	:	:
cord-302047-vv5gpldi	539	12	Positional	Positional	NNP
cord-302047-vv5gpldi	539	13	Effects	effect	NNS
cord-302047-vv5gpldi	539	14	on	on	IN
cord-302047-vv5gpldi	539	15	Stability	stability	NN
cord-302047-vv5gpldi	539	16	of	of	IN
cord-302047-vv5gpldi	539	17	Expression	expression	NN
cord-302047-vv5gpldi	539	18	Predicting	predict	VBG
cord-302047-vv5gpldi	539	19	the	the	DT
cord-302047-vv5gpldi	539	20	Stability	stability	NN
cord-302047-vv5gpldi	539	21	of	of	IN
cord-302047-vv5gpldi	539	22	Homologous	Homologous	NNP
cord-302047-vv5gpldi	539	23	Gene	Gene	NNP
cord-302047-vv5gpldi	539	24	Duplications	duplication	NNS
cord-302047-vv5gpldi	539	25	in	in	IN
cord-302047-vv5gpldi	539	26	a	a	DT
cord-302047-vv5gpldi	539	27	Plant	Plant	NNP
cord-302047-vv5gpldi	539	28	RNA	RNA	NNP
cord-302047-vv5gpldi	539	29	Virus	virus	NN
cord-302047-vv5gpldi	539	30	High	high	JJ
cord-302047-vv5gpldi	539	31	Virulence	Virulence	NNP
cord-302047-vv5gpldi	540	1	Does	do	VBZ
cord-302047-vv5gpldi	540	2	Not	not	RB
cord-302047-vv5gpldi	540	3	Necessarily	necessarily	RB
cord-302047-vv5gpldi	540	4	Impede	impede	VB
cord-302047-vv5gpldi	540	5	Viral	viral	JJ
cord-302047-vv5gpldi	540	6	Adaptation	adaptation	NN
cord-302047-vv5gpldi	540	7	to	to	IN
cord-302047-vv5gpldi	540	8	a	a	DT
cord-302047-vv5gpldi	540	9	New	New	NNP
cord-302047-vv5gpldi	540	10	Host	host	NN
cord-302047-vv5gpldi	540	11	:	:	:
cord-302047-vv5gpldi	541	1	A	a	DT
cord-302047-vv5gpldi	541	2	Case	Case	NNP
cord-302047-vv5gpldi	541	3	Study	Study	NNP
cord-302047-vv5gpldi	541	4	Using	use	VBG
cord-302047-vv5gpldi	541	5	a	a	DT
cord-302047-vv5gpldi	541	6	Plant	Plant	NNP
cord-302047-vv5gpldi	541	7	RNA	RNA	NNP
cord-302047-vv5gpldi	541	8	Virus	virus	NN
cord-302047-vv5gpldi	541	9	Effects	effect	NNS
cord-302047-vv5gpldi	541	10	of	of	IN
cord-302047-vv5gpldi	541	11	Palindrome	Palindrome	NNP
cord-302047-vv5gpldi	541	12	Size	size	NN
cord-302047-vv5gpldi	541	13	and	and	CC
cord-302047-vv5gpldi	541	14	Sequence	sequence	NN
cord-302047-vv5gpldi	541	15	on	on	IN
cord-302047-vv5gpldi	541	16	Genetic	genetic	JJ
cord-302047-vv5gpldi	541	17	Stability	stability	NN
cord-302047-vv5gpldi	541	18	in	in	IN
cord-302047-vv5gpldi	541	19	the	the	DT
cord-302047-vv5gpldi	541	20	Bacteriophage	Bacteriophage	NNP
cord-302047-vv5gpldi	541	21	/X174	/X174	NNP
cord-302047-vv5gpldi	541	22	Advancement	Advancement	NNP
cord-302047-vv5gpldi	541	23	and	and	CC
cord-302047-vv5gpldi	541	24	Applications	Applications	NNPS
cord-302047-vv5gpldi	541	25	of	of	IN
cord-302047-vv5gpldi	541	26	Peptide	Peptide	NNP
cord-302047-vv5gpldi	541	27	Phage	Phage	NNP
cord-302047-vv5gpldi	541	28	Display	Display	NNP
cord-302047-vv5gpldi	541	29	Technology	Technology	NNP
cord-302047-vv5gpldi	541	30	in	in	IN
cord-302047-vv5gpldi	541	31	Biomedical	Biomedical	NNP
cord-302047-vv5gpldi	541	32	Science	Science	NNP
cord-302047-vv5gpldi	541	33	Construction	Construction	NNP
cord-302047-vv5gpldi	541	34	and	and	CC
cord-302047-vv5gpldi	541	35	In	in	IN
cord-302047-vv5gpldi	541	36	Vitro	Vitro	NNP
cord-302047-vv5gpldi	541	37	Evaluation	Evaluation	NNP
cord-302047-vv5gpldi	541	38	of	of	IN
cord-302047-vv5gpldi	541	39	a	a	DT
cord-302047-vv5gpldi	541	40	Recombinant	recombinant	JJ
cord-302047-vv5gpldi	541	41	Live	live	JJ
cord-302047-vv5gpldi	541	42	Attenuated	attenuated	JJ
cord-302047-vv5gpldi	541	43	PRRSV	prrsv	NN
cord-302047-vv5gpldi	542	1	Expressing	express	VBG
cord-302047-vv5gpldi	542	2	GM	GM	NNP
cord-302047-vv5gpldi	542	3	-	-	HYPH
cord-302047-vv5gpldi	542	4	CSF	CSF	NNP
cord-302047-vv5gpldi	542	5	Recombinant	Recombinant	NNP
cord-302047-vv5gpldi	542	6	Newcastle	Newcastle	NNP
cord-302047-vv5gpldi	542	7	Disease	Disease	NNP
cord-302047-vv5gpldi	542	8	Virus	Virus	NNP
cord-302047-vv5gpldi	542	9	as	as	IN
cord-302047-vv5gpldi	542	10	a	a	DT
cord-302047-vv5gpldi	542	11	Viral	viral	JJ
cord-302047-vv5gpldi	542	12	Vector	vector	NN
cord-302047-vv5gpldi	542	13	:	:	:
cord-302047-vv5gpldi	543	1	Effect	effect	NN
cord-302047-vv5gpldi	543	2	of	of	IN
cord-302047-vv5gpldi	543	3	Genomic	Genomic	NNP
cord-302047-vv5gpldi	543	4	Location	Location	NNP
cord-302047-vv5gpldi	543	5	of	of	IN
cord-302047-vv5gpldi	543	6	Foreign	Foreign	NNP
cord-302047-vv5gpldi	543	7	Gene	Gene	NNP
cord-302047-vv5gpldi	543	8	on	on	IN
cord-302047-vv5gpldi	543	9	Gene	Gene	NNP
cord-302047-vv5gpldi	543	10	Expression	Expression	NNP
cord-302047-vv5gpldi	543	11	and	and	CC
cord-302047-vv5gpldi	543	12	Virus	virus	NN
cord-302047-vv5gpldi	543	13	Replication	Replication	NNP
cord-302047-vv5gpldi	543	14	Matters	Matters	NNPS
cord-302047-vv5gpldi	543	15	of	of	IN
cord-302047-vv5gpldi	543	16	Size	size	NN
cord-302047-vv5gpldi	543	17	:	:	:
cord-302047-vv5gpldi	543	18	Genetic	genetic	JJ
cord-302047-vv5gpldi	543	19	Bottlenecks	bottleneck	NNS
cord-302047-vv5gpldi	543	20	in	in	IN
cord-302047-vv5gpldi	543	21	Virus	Virus	NNP
cord-302047-vv5gpldi	543	22	Infection	Infection	NNP
cord-302047-vv5gpldi	543	23	and	and	CC
cord-302047-vv5gpldi	543	24	Their	-PRON-	PRP$
cord-302047-vv5gpldi	543	25	Potential	Potential	NNP
cord-302047-vv5gpldi	543	26	Impact	Impact	NNP
cord-302047-vv5gpldi	543	27	on	on	IN
cord-302047-vv5gpldi	543	28	Evolution	evolution	NN