id	sid	tid	token	lemma	pos
cord-018804-wj35q88f	1	1	key	key	JJ
cord-018804-wj35q88f	2	1	:	:	:
cord-018804-wj35q88f	2	2	cord-018804-wj35q88f	cord-018804-wj35q88f	NN
cord-018804-wj35q88f	2	3	authors	author	NNS
cord-018804-wj35q88f	2	4	:	:	:
cord-018804-wj35q88f	3	1	Lázaro	Lázaro	NNP
cord-018804-wj35q88f	3	2	,	,	,
cord-018804-wj35q88f	3	3	Ester	Ester	NNP
cord-018804-wj35q88f	3	4	title	title	NN
cord-018804-wj35q88f	3	5	:	:	:
cord-018804-wj35q88f	3	6	Genetic	genetic	JJ
cord-018804-wj35q88f	3	7	Variability	variability	NN
cord-018804-wj35q88f	3	8	in	in	IN
cord-018804-wj35q88f	3	9	RNA	RNA	NNP
cord-018804-wj35q88f	3	10	Viruses	virus	NNS
cord-018804-wj35q88f	3	11	:	:	:
cord-018804-wj35q88f	4	1	Consequences	consequence	NNS
cord-018804-wj35q88f	4	2	in	in	IN
cord-018804-wj35q88f	4	3	Epidemiology	Epidemiology	NNP
cord-018804-wj35q88f	4	4	and	and	CC
cord-018804-wj35q88f	4	5	in	in	IN
cord-018804-wj35q88f	4	6	the	the	DT
cord-018804-wj35q88f	4	7	Development	Development	NNP
cord-018804-wj35q88f	4	8	of	of	IN
cord-018804-wj35q88f	4	9	New	New	NNP
cord-018804-wj35q88f	4	10	Stratgies	Stratgies	NNPS
cord-018804-wj35q88f	4	11	for	for	IN
cord-018804-wj35q88f	4	12	the	the	DT
cord-018804-wj35q88f	4	13	Extinction	extinction	NN
cord-018804-wj35q88f	4	14	of	of	IN
cord-018804-wj35q88f	4	15	Infectivity	Infectivity	NNP
cord-018804-wj35q88f	4	16	date	date	NN
cord-018804-wj35q88f	4	17	:	:	:
cord-018804-wj35q88f	4	18	2007	2007	CD
cord-018804-wj35q88f	4	19	journal	journal	NNP
cord-018804-wj35q88f	4	20	:	:	:
cord-018804-wj35q88f	5	1	Structural	structural	JJ
cord-018804-wj35q88f	5	2	Approaches	approach	NNS
cord-018804-wj35q88f	5	3	to	to	IN
cord-018804-wj35q88f	6	1	Sequence	sequence	NN
cord-018804-wj35q88f	6	2	Evolution	evolution	NN
cord-018804-wj35q88f	6	3	DOI	doi	NN
cord-018804-wj35q88f	6	4	:	:	:
cord-018804-wj35q88f	6	5	10.1007/978	10.1007/978	CD
cord-018804-wj35q88f	6	6	-	-	HYPH
cord-018804-wj35q88f	6	7	3	3	CD
cord-018804-wj35q88f	6	8	-	-	HYPH
cord-018804-wj35q88f	6	9	540	540	CD
cord-018804-wj35q88f	6	10	-	-	HYPH
cord-018804-wj35q88f	6	11	35306	35306	CD
cord-018804-wj35q88f	6	12	-	-	HYPH
cord-018804-wj35q88f	6	13	5_15	5_15	CD
cord-018804-wj35q88f	6	14	sha	sha	NNP
cord-018804-wj35q88f	6	15	:	:	:
cord-018804-wj35q88f	7	1	cd360eef634a7915363efe4ba7ac851a7857179b	cd360eef634a7915363efe4ba7ac851a7857179b	NNP
cord-018804-wj35q88f	7	2	doc_id	doc_id	NNP
cord-018804-wj35q88f	7	3	:	:	:
cord-018804-wj35q88f	7	4	18804	18804	CD
cord-018804-wj35q88f	7	5	cord_uid	cord_uid	NNS
cord-018804-wj35q88f	7	6	:	:	:
cord-018804-wj35q88f	8	1	wj35q88f	wj35q88f	NNP
cord-018804-wj35q88f	9	1	nan	nan	NNP
cord-018804-wj35q88f	9	2	Viruses	Viruses	NNP
cord-018804-wj35q88f	9	3	constitute	constitute	VBP
cord-018804-wj35q88f	9	4	one	one	CD
cord-018804-wj35q88f	9	5	of	of	IN
cord-018804-wj35q88f	9	6	the	the	DT
cord-018804-wj35q88f	9	7	simplest	simple	JJS
cord-018804-wj35q88f	9	8	biological	biological	JJ
cord-018804-wj35q88f	9	9	entities	entity	NNS
cord-018804-wj35q88f	9	10	in	in	IN
cord-018804-wj35q88f	9	11	nature	nature	NN
cord-018804-wj35q88f	9	12	.	.	.
cord-018804-wj35q88f	10	1	They	-PRON-	PRP
cord-018804-wj35q88f	10	2	possess	possess	VBP
cord-018804-wj35q88f	10	3	some	some	DT
cord-018804-wj35q88f	10	4	properties	property	NNS
cord-018804-wj35q88f	10	5	typical	typical	JJ
cord-018804-wj35q88f	10	6	of	of	IN
cord-018804-wj35q88f	10	7	life	life	NN
cord-018804-wj35q88f	10	8	,	,	,
cord-018804-wj35q88f	10	9	such	such	JJ
cord-018804-wj35q88f	10	10	as	as	IN
cord-018804-wj35q88f	10	11	the	the	DT
cord-018804-wj35q88f	10	12	transmission	transmission	NN
cord-018804-wj35q88f	10	13	of	of	IN
cord-018804-wj35q88f	10	14	genetic	genetic	JJ
cord-018804-wj35q88f	10	15	information	information	NN
cord-018804-wj35q88f	10	16	through	through	IN
cord-018804-wj35q88f	10	17	generations	generation	NNS
cord-018804-wj35q88f	10	18	,	,	,
cord-018804-wj35q88f	10	19	but	but	CC
cord-018804-wj35q88f	10	20	lack	lack	VBP
cord-018804-wj35q88f	10	21	a	a	DT
cord-018804-wj35q88f	10	22	proper	proper	JJ
cord-018804-wj35q88f	10	23	metabolism	metabolism	NN
cord-018804-wj35q88f	10	24	and	and	CC
cord-018804-wj35q88f	10	25	a	a	DT
cord-018804-wj35q88f	10	26	system	system	NN
cord-018804-wj35q88f	10	27	to	to	TO
cord-018804-wj35q88f	10	28	translate	translate	VB
cord-018804-wj35q88f	10	29	the	the	DT
cord-018804-wj35q88f	10	30	genetic	genetic	JJ
cord-018804-wj35q88f	10	31	information	information	NN
cord-018804-wj35q88f	10	32	into	into	IN
cord-018804-wj35q88f	10	33	proteins	protein	NNS
cord-018804-wj35q88f	10	34	.	.	.
cord-018804-wj35q88f	11	1	This	this	DT
cord-018804-wj35q88f	11	2	ambivalence	ambivalence	NN
cord-018804-wj35q88f	11	3	places	place	VBZ
cord-018804-wj35q88f	11	4	them	-PRON-	PRP
cord-018804-wj35q88f	11	5	at	at	IN
cord-018804-wj35q88f	11	6	the	the	DT
cord-018804-wj35q88f	11	7	border	border	NN
cord-018804-wj35q88f	11	8	between	between	IN
cord-018804-wj35q88f	11	9	living	living	NN
cord-018804-wj35q88f	11	10	and	and	CC
cord-018804-wj35q88f	11	11	non	non	JJ
cord-018804-wj35q88f	11	12	-	-	JJ
cord-018804-wj35q88f	11	13	living	living	JJ
cord-018804-wj35q88f	11	14	matter	matter	NN
cord-018804-wj35q88f	11	15	.	.	.
cord-018804-wj35q88f	12	1	To	to	TO
cord-018804-wj35q88f	12	2	reproduce	reproduce	VB
cord-018804-wj35q88f	12	3	themselves	-PRON-	PRP
cord-018804-wj35q88f	12	4	,	,	,
cord-018804-wj35q88f	12	5	viruses	virus	NNS
cord-018804-wj35q88f	12	6	are	be	VBP
cord-018804-wj35q88f	12	7	forced	force	VBN
cord-018804-wj35q88f	12	8	to	to	TO
cord-018804-wj35q88f	12	9	infect	infect	VB
cord-018804-wj35q88f	12	10	a	a	DT
cord-018804-wj35q88f	12	11	host	host	NN
cord-018804-wj35q88f	12	12	cell	cell	NN
cord-018804-wj35q88f	12	13	,	,	,
cord-018804-wj35q88f	12	14	behaving	behave	VBG
cord-018804-wj35q88f	12	15	as	as	IN
cord-018804-wj35q88f	12	16	intra	intra	JJ
cord-018804-wj35q88f	12	17	-	-	JJ
cord-018804-wj35q88f	12	18	cellular	cellular	JJ
cord-018804-wj35q88f	12	19	parasites	parasite	NNS
cord-018804-wj35q88f	12	20	.	.	.
cord-018804-wj35q88f	13	1	Despite	despite	IN
cord-018804-wj35q88f	13	2	their	-PRON-	PRP$
cord-018804-wj35q88f	13	3	simplicity	simplicity	NN
cord-018804-wj35q88f	13	4	,	,	,
cord-018804-wj35q88f	13	5	viruses	virus	NNS
cord-018804-wj35q88f	13	6	have	have	VBP
cord-018804-wj35q88f	13	7	been	be	VBN
cord-018804-wj35q88f	13	8	able	able	JJ
cord-018804-wj35q88f	13	9	to	to	TO
cord-018804-wj35q88f	13	10	develop	develop	VB
cord-018804-wj35q88f	13	11	a	a	DT
cord-018804-wj35q88f	13	12	wide	wide	JJ
cord-018804-wj35q88f	13	13	repertoire	repertoire	NN
cord-018804-wj35q88f	13	14	of	of	IN
cord-018804-wj35q88f	13	15	infection	infection	NN
cord-018804-wj35q88f	13	16	mechanisms	mechanism	NNS
cord-018804-wj35q88f	13	17	and	and	CC
cord-018804-wj35q88f	13	18	replication	replication	NN
cord-018804-wj35q88f	13	19	strategies	strategy	NNS
cord-018804-wj35q88f	13	20	to	to	TO
cord-018804-wj35q88f	13	21	adapt	adapt	VB
cord-018804-wj35q88f	13	22	to	to	IN
cord-018804-wj35q88f	13	23	the	the	DT
cord-018804-wj35q88f	13	24	broad	broad	JJ
cord-018804-wj35q88f	13	25	diversity	diversity	NN
cord-018804-wj35q88f	13	26	of	of	IN
cord-018804-wj35q88f	13	27	the	the	DT
cord-018804-wj35q88f	13	28	cellular	cellular	JJ
cord-018804-wj35q88f	13	29	world	world	NN
cord-018804-wj35q88f	13	30	in	in	IN
cord-018804-wj35q88f	13	31	order	order	NN
cord-018804-wj35q88f	13	32	to	to	TO
cord-018804-wj35q88f	13	33	execute	execute	VB
cord-018804-wj35q88f	13	34	their	-PRON-	PRP$
cord-018804-wj35q88f	13	35	genetic	genetic	JJ
cord-018804-wj35q88f	13	36	program	program	NN
cord-018804-wj35q88f	13	37	.	.	.
cord-018804-wj35q88f	14	1	All	all	DT
cord-018804-wj35q88f	14	2	known	know	VBN
cord-018804-wj35q88f	14	3	viruses	virus	NNS
cord-018804-wj35q88f	14	4	consist	consist	VBP
cord-018804-wj35q88f	14	5	of	of	IN
cord-018804-wj35q88f	14	6	one	one	CD
cord-018804-wj35q88f	14	7	or	or	CC
cord-018804-wj35q88f	14	8	several	several	JJ
cord-018804-wj35q88f	14	9	genomic	genomic	JJ
cord-018804-wj35q88f	14	10	nucleic	nucleic	JJ
cord-018804-wj35q88f	14	11	acid	acid	NN
cord-018804-wj35q88f	14	12	molecules	molecule	NNS
cord-018804-wj35q88f	14	13	,	,	,
cord-018804-wj35q88f	14	14	covered	cover	VBN
cord-018804-wj35q88f	14	15	by	by	IN
cord-018804-wj35q88f	14	16	protective	protective	JJ
cord-018804-wj35q88f	14	17	layers	layer	NNS
cord-018804-wj35q88f	14	18	.	.	.
cord-018804-wj35q88f	15	1	Usually	usually	RB
cord-018804-wj35q88f	15	2	,	,	,
cord-018804-wj35q88f	15	3	there	there	EX
cord-018804-wj35q88f	15	4	is	be	VBZ
cord-018804-wj35q88f	15	5	one	one	CD
cord-018804-wj35q88f	15	6	protein	protein	NN
cord-018804-wj35q88f	15	7	capside	capside	RB
cord-018804-wj35q88f	15	8	that	that	WDT
cord-018804-wj35q88f	15	9	can	can	MD
cord-018804-wj35q88f	15	10	be	be	VB
cord-018804-wj35q88f	15	11	enclosed	enclose	VBN
cord-018804-wj35q88f	15	12	by	by	IN
cord-018804-wj35q88f	15	13	a	a	DT
cord-018804-wj35q88f	15	14	lipid	lipid	NN
cord-018804-wj35q88f	15	15	bilayer	bilayer	NN
cord-018804-wj35q88f	15	16	membrane	membrane	NN
cord-018804-wj35q88f	15	17	proceeding	proceed	VBG
cord-018804-wj35q88f	15	18	from	from	IN
cord-018804-wj35q88f	15	19	the	the	DT
cord-018804-wj35q88f	15	20	host	host	NN
cord-018804-wj35q88f	15	21	cell	cell	NN
cord-018804-wj35q88f	15	22	.	.	.
cord-018804-wj35q88f	16	1	The	the	DT
cord-018804-wj35q88f	16	2	number	number	NN
cord-018804-wj35q88f	16	3	of	of	IN
cord-018804-wj35q88f	16	4	proteins	protein	NNS
cord-018804-wj35q88f	16	5	encoded	encode	VBN
cord-018804-wj35q88f	16	6	by	by	IN
cord-018804-wj35q88f	16	7	the	the	DT
cord-018804-wj35q88f	16	8	viral	viral	JJ
cord-018804-wj35q88f	16	9	genomes	genome	NNS
cord-018804-wj35q88f	16	10	is	be	VBZ
cord-018804-wj35q88f	16	11	rather	rather	RB
cord-018804-wj35q88f	16	12	small	small	JJ
cord-018804-wj35q88f	16	13	,	,	,
cord-018804-wj35q88f	16	14	making	make	VBG
cord-018804-wj35q88f	16	15	their	-PRON-	PRP$
cord-018804-wj35q88f	16	16	success	success	NN
cord-018804-wj35q88f	16	17	to	to	TO
cord-018804-wj35q88f	16	18	replicate	replicate	VB
cord-018804-wj35q88f	16	19	and	and	CC
cord-018804-wj35q88f	16	20	give	give	VB
cord-018804-wj35q88f	16	21	rise	rise	NN
cord-018804-wj35q88f	16	22	to	to	IN
cord-018804-wj35q88f	16	23	an	an	DT
cord-018804-wj35q88f	16	24	offspring	offspring	NN
cord-018804-wj35q88f	16	25	dependent	dependent	JJ
cord-018804-wj35q88f	16	26	on	on	IN
cord-018804-wj35q88f	16	27	their	-PRON-	PRP$
cord-018804-wj35q88f	16	28	ability	ability	NN
cord-018804-wj35q88f	16	29	to	to	TO
cord-018804-wj35q88f	16	30	take	take	VB
cord-018804-wj35q88f	16	31	advantage	advantage	NN
cord-018804-wj35q88f	16	32	of	of	IN
cord-018804-wj35q88f	16	33	the	the	DT
cord-018804-wj35q88f	16	34	enzymatic	enzymatic	JJ
cord-018804-wj35q88f	16	35	activities	activity	NNS
cord-018804-wj35q88f	16	36	provided	provide	VBN
cord-018804-wj35q88f	16	37	by	by	IN
cord-018804-wj35q88f	16	38	the	the	DT
cord-018804-wj35q88f	16	39	host	host	NN
cord-018804-wj35q88f	16	40	cell	cell	NN
cord-018804-wj35q88f	16	41	.	.	.
cord-018804-wj35q88f	17	1	After	after	IN
cord-018804-wj35q88f	17	2	infection	infection	NN
cord-018804-wj35q88f	17	3	,	,	,
cord-018804-wj35q88f	17	4	cellular	cellular	JJ
cord-018804-wj35q88f	17	5	protein	protein	NN
cord-018804-wj35q88f	17	6	synthesis	synthesis	NN
cord-018804-wj35q88f	17	7	is	be	VBZ
cord-018804-wj35q88f	17	8	stopped	stop	VBN
cord-018804-wj35q88f	17	9	and	and	CC
cord-018804-wj35q88f	17	10	most	most	JJS
cord-018804-wj35q88f	17	11	of	of	IN
cord-018804-wj35q88f	17	12	the	the	DT
cord-018804-wj35q88f	17	13	subcellular	subcellular	JJ
cord-018804-wj35q88f	17	14	machinery	machinery	NN
cord-018804-wj35q88f	17	15	is	be	VBZ
cord-018804-wj35q88f	17	16	directed	direct	VBN
cord-018804-wj35q88f	17	17	to	to	TO
cord-018804-wj35q88f	17	18	produce	produce	VB
cord-018804-wj35q88f	17	19	copies	copy	NNS
cord-018804-wj35q88f	17	20	of	of	IN
cord-018804-wj35q88f	17	21	the	the	DT
cord-018804-wj35q88f	17	22	viral	viral	JJ
cord-018804-wj35q88f	17	23	nucleic	nucleic	JJ
cord-018804-wj35q88f	17	24	acids	acid	NNS
cord-018804-wj35q88f	17	25	and	and	CC
cord-018804-wj35q88f	17	26	proteins	protein	NNS
cord-018804-wj35q88f	17	27	.	.	.
cord-018804-wj35q88f	18	1	These	these	DT
cord-018804-wj35q88f	18	2	newly	newly	RB
cord-018804-wj35q88f	18	3	synthesized	synthesize	VBN
cord-018804-wj35q88f	18	4	viral	viral	JJ
cord-018804-wj35q88f	18	5	components	component	NNS
cord-018804-wj35q88f	18	6	are	be	VBP
cord-018804-wj35q88f	18	7	assembled	assemble	VBN
cord-018804-wj35q88f	18	8	inside	inside	IN
cord-018804-wj35q88f	18	9	the	the	DT
cord-018804-wj35q88f	18	10	cell	cell	NN
cord-018804-wj35q88f	18	11	into	into	IN
cord-018804-wj35q88f	18	12	mature	mature	JJ
cord-018804-wj35q88f	18	13	virions	virion	NNS
cord-018804-wj35q88f	18	14	that	that	WDT
cord-018804-wj35q88f	18	15	can	can	MD
cord-018804-wj35q88f	18	16	infect	infect	VB
cord-018804-wj35q88f	18	17	other	other	JJ
cord-018804-wj35q88f	18	18	cells	cell	NNS
cord-018804-wj35q88f	18	19	of	of	IN
cord-018804-wj35q88f	18	20	the	the	DT
cord-018804-wj35q88f	18	21	same	same	JJ
cord-018804-wj35q88f	18	22	organism	organism	NN
cord-018804-wj35q88f	18	23	or	or	CC
cord-018804-wj35q88f	18	24	establish	establish	VB
cord-018804-wj35q88f	18	25	transmission	transmission	NN
cord-018804-wj35q88f	18	26	chains	chain	NNS
cord-018804-wj35q88f	18	27	between	between	IN
cord-018804-wj35q88f	18	28	different	different	JJ
cord-018804-wj35q88f	18	29	individuals	individual	NNS
cord-018804-wj35q88f	18	30	.	.	.
cord-018804-wj35q88f	19	1	The	the	DT
cord-018804-wj35q88f	19	2	stability	stability	NN
cord-018804-wj35q88f	19	3	of	of	IN
cord-018804-wj35q88f	19	4	these	these	DT
cord-018804-wj35q88f	19	5	chains	chain	NNS
cord-018804-wj35q88f	19	6	strongly	strongly	RB
cord-018804-wj35q88f	19	7	conditions	condition	VBZ
cord-018804-wj35q88f	19	8	the	the	DT
cord-018804-wj35q88f	19	9	survival	survival	NN
cord-018804-wj35q88f	19	10	of	of	IN
cord-018804-wj35q88f	19	11	the	the	DT
cord-018804-wj35q88f	19	12	virus	virus	NN
cord-018804-wj35q88f	19	13	in	in	IN
cord-018804-wj35q88f	19	14	nature	nature	NN
cord-018804-wj35q88f	19	15	.	.	.
cord-018804-wj35q88f	20	1	Outside	outside	IN
cord-018804-wj35q88f	20	2	an	an	DT
cord-018804-wj35q88f	20	3	adequate	adequate	JJ
cord-018804-wj35q88f	20	4	host	host	NN
cord-018804-wj35q88f	20	5	,	,	,
cord-018804-wj35q88f	20	6	viruses	virus	NNS
cord-018804-wj35q88f	20	7	can	can	MD
cord-018804-wj35q88f	20	8	still	still	RB
cord-018804-wj35q88f	20	9	persist	persist	VB
cord-018804-wj35q88f	20	10	for	for	IN
cord-018804-wj35q88f	20	11	some	some	DT
cord-018804-wj35q88f	20	12	time	time	NN
cord-018804-wj35q88f	20	13	in	in	IN
cord-018804-wj35q88f	20	14	a	a	DT
cord-018804-wj35q88f	20	15	latent	latent	JJ
cord-018804-wj35q88f	20	16	state	state	NN
cord-018804-wj35q88f	20	17	in	in	IN
cord-018804-wj35q88f	20	18	which	which	WDT
cord-018804-wj35q88f	20	19	they	-PRON-	PRP
cord-018804-wj35q88f	20	20	are	be	VBP
cord-018804-wj35q88f	20	21	unable	unable	JJ
cord-018804-wj35q88f	20	22	to	to	TO
cord-018804-wj35q88f	20	23	replicate	replicate	VB
cord-018804-wj35q88f	20	24	and	and	CC
cord-018804-wj35q88f	20	25	exposed	expose	VBN
cord-018804-wj35q88f	20	26	to	to	IN
cord-018804-wj35q88f	20	27	irreversible	irreversible	JJ
cord-018804-wj35q88f	20	28	damage	damage	NN
cord-018804-wj35q88f	20	29	by	by	IN
cord-018804-wj35q88f	20	30	physical	physical	JJ
cord-018804-wj35q88f	20	31	conditions	condition	NNS
cord-018804-wj35q88f	20	32	of	of	IN
cord-018804-wj35q88f	20	33	the	the	DT
cord-018804-wj35q88f	20	34	environment	environment	NN
cord-018804-wj35q88f	20	35	.	.	.
cord-018804-wj35q88f	21	1	When	when	WRB
cord-018804-wj35q88f	21	2	they	-PRON-	PRP
cord-018804-wj35q88f	21	3	interact	interact	VBP
cord-018804-wj35q88f	21	4	with	with	IN
cord-018804-wj35q88f	21	5	the	the	DT
cord-018804-wj35q88f	21	6	specific	specific	JJ
cord-018804-wj35q88f	21	7	cellular	cellular	JJ
cord-018804-wj35q88f	21	8	receptors	receptor	NNS
cord-018804-wj35q88f	21	9	of	of	IN
cord-018804-wj35q88f	21	10	a	a	DT
cord-018804-wj35q88f	21	11	suitable	suitable	JJ
cord-018804-wj35q88f	21	12	host	host	NN
cord-018804-wj35q88f	21	13	,	,	,
cord-018804-wj35q88f	21	14	they	-PRON-	PRP
cord-018804-wj35q88f	21	15	can	can	MD
cord-018804-wj35q88f	21	16	initiate	initiate	VB
cord-018804-wj35q88f	21	17	an	an	DT
cord-018804-wj35q88f	21	18	infection	infection	NN
cord-018804-wj35q88f	21	19	that	that	WDT
cord-018804-wj35q88f	21	20	,	,	,
cord-018804-wj35q88f	21	21	if	if	IN
cord-018804-wj35q88f	21	22	successfully	successfully	RB
cord-018804-wj35q88f	21	23	transmitted	transmit	VBN
cord-018804-wj35q88f	21	24	in	in	IN
cord-018804-wj35q88f	21	25	the	the	DT
cord-018804-wj35q88f	21	26	population	population	NN
cord-018804-wj35q88f	21	27	,	,	,
cord-018804-wj35q88f	21	28	can	can	MD
cord-018804-wj35q88f	21	29	seriously	seriously	RB
cord-018804-wj35q88f	21	30	compromise	compromise	VB
cord-018804-wj35q88f	21	31	the	the	DT
cord-018804-wj35q88f	21	32	survival	survival	NN
cord-018804-wj35q88f	21	33	of	of	IN
cord-018804-wj35q88f	21	34	the	the	DT
cord-018804-wj35q88f	21	35	host	host	NN
cord-018804-wj35q88f	21	36	species	specie	NNS
cord-018804-wj35q88f	21	37	.	.	.
cord-018804-wj35q88f	22	1	In	in	IN
cord-018804-wj35q88f	22	2	all	all	DT
cord-018804-wj35q88f	22	3	cellular	cellular	JJ
cord-018804-wj35q88f	22	4	organisms	organism	NNS
cord-018804-wj35q88f	22	5	,	,	,
cord-018804-wj35q88f	22	6	the	the	DT
cord-018804-wj35q88f	22	7	genetic	genetic	JJ
cord-018804-wj35q88f	22	8	information	information	NN
cord-018804-wj35q88f	22	9	is	be	VBZ
cord-018804-wj35q88f	22	10	contained	contain	VBN
cord-018804-wj35q88f	22	11	in	in	IN
cord-018804-wj35q88f	22	12	the	the	DT
cord-018804-wj35q88f	22	13	DNA	dna	NN
cord-018804-wj35q88f	22	14	.	.	.
cord-018804-wj35q88f	23	1	Before	before	IN
cord-018804-wj35q88f	23	2	being	be	VBG
cord-018804-wj35q88f	23	3	translated	translate	VBN
cord-018804-wj35q88f	23	4	into	into	IN
cord-018804-wj35q88f	23	5	proteins	protein	NNS
cord-018804-wj35q88f	23	6	(	(	-LRB-
cord-018804-wj35q88f	23	7	the	the	DT
cord-018804-wj35q88f	23	8	molecules	molecule	NNS
cord-018804-wj35q88f	23	9	that	that	WDT
cord-018804-wj35q88f	23	10	execute	execute	VBP
cord-018804-wj35q88f	23	11	the	the	DT
cord-018804-wj35q88f	23	12	functions	function	NNS
cord-018804-wj35q88f	23	13	necessary	necessary	JJ
cord-018804-wj35q88f	23	14	for	for	IN
cord-018804-wj35q88f	23	15	the	the	DT
cord-018804-wj35q88f	23	16	performance	performance	NN
cord-018804-wj35q88f	23	17	of	of	IN
cord-018804-wj35q88f	23	18	the	the	DT
cord-018804-wj35q88f	23	19	cell	cell	NN
cord-018804-wj35q88f	23	20	)	)	-RRB-
cord-018804-wj35q88f	23	21	,	,	,
cord-018804-wj35q88f	23	22	the	the	DT
cord-018804-wj35q88f	23	23	DNA	dna	NN
cord-018804-wj35q88f	23	24	has	have	VBZ
cord-018804-wj35q88f	23	25	to	to	TO
cord-018804-wj35q88f	23	26	be	be	VB
cord-018804-wj35q88f	23	27	copied	copy	VBN
cord-018804-wj35q88f	23	28	to	to	IN
cord-018804-wj35q88f	23	29	mRNA	mRNA	NNP
cord-018804-wj35q88f	23	30	.	.	.
cord-018804-wj35q88f	24	1	But	but	CC
cord-018804-wj35q88f	24	2	genetic	genetic	JJ
cord-018804-wj35q88f	24	3	information	information	NN
cord-018804-wj35q88f	24	4	also	also	RB
cord-018804-wj35q88f	24	5	needs	need	VBZ
cord-018804-wj35q88f	24	6	to	to	TO
cord-018804-wj35q88f	24	7	be	be	VB
cord-018804-wj35q88f	24	8	maintained	maintain	VBN
cord-018804-wj35q88f	24	9	through	through	IN
cord-018804-wj35q88f	24	10	generations	generation	NNS
cord-018804-wj35q88f	24	11	,	,	,
cord-018804-wj35q88f	24	12	a	a	DT
cord-018804-wj35q88f	24	13	process	process	NN
cord-018804-wj35q88f	24	14	that	that	WDT
cord-018804-wj35q88f	24	15	takes	take	VBZ
cord-018804-wj35q88f	24	16	place	place	NN
cord-018804-wj35q88f	24	17	by	by	IN
cord-018804-wj35q88f	24	18	means	mean	NNS
cord-018804-wj35q88f	24	19	of	of	IN
cord-018804-wj35q88f	24	20	DNA	dna	NN
cord-018804-wj35q88f	24	21	replication	replication	NN
cord-018804-wj35q88f	24	22	,	,	,
cord-018804-wj35q88f	24	23	in	in	IN
cord-018804-wj35q88f	24	24	which	which	WDT
cord-018804-wj35q88f	24	25	many	many	JJ
cord-018804-wj35q88f	24	26	enzymatic	enzymatic	JJ
cord-018804-wj35q88f	24	27	activities	activity	NNS
cord-018804-wj35q88f	24	28	are	be	VBP
cord-018804-wj35q88f	24	29	involved	involve	VBN
cord-018804-wj35q88f	24	30	.	.	.
cord-018804-wj35q88f	25	1	In	in	IN
cord-018804-wj35q88f	25	2	contrast	contrast	NN
cord-018804-wj35q88f	25	3	to	to	IN
cord-018804-wj35q88f	25	4	cells	cell	NNS
cord-018804-wj35q88f	25	5	,	,	,
cord-018804-wj35q88f	25	6	viruses	virus	NNS
cord-018804-wj35q88f	25	7	are	be	VBP
cord-018804-wj35q88f	25	8	more	more	RBR
cord-018804-wj35q88f	25	9	versatile	versatile	JJ
cord-018804-wj35q88f	25	10	and	and	CC
cord-018804-wj35q88f	25	11	can	can	MD
cord-018804-wj35q88f	25	12	use	use	VB
cord-018804-wj35q88f	25	13	DNA	DNA	NNP
cord-018804-wj35q88f	25	14	or	or	CC
cord-018804-wj35q88f	25	15	RNA	RNA	NNP
cord-018804-wj35q88f	25	16	to	to	TO
cord-018804-wj35q88f	25	17	store	store	VB
cord-018804-wj35q88f	25	18	the	the	DT
cord-018804-wj35q88f	25	19	genetic	genetic	JJ
cord-018804-wj35q88f	25	20	information	information	NN
cord-018804-wj35q88f	25	21	.	.	.
cord-018804-wj35q88f	26	1	DNA	dna	NN
cord-018804-wj35q88f	26	2	viruses	virus	NNS
cord-018804-wj35q88f	26	3	can	can	MD
cord-018804-wj35q88f	26	4	follow	follow	VB
cord-018804-wj35q88f	26	5	a	a	DT
cord-018804-wj35q88f	26	6	scheme	scheme	NN
cord-018804-wj35q88f	26	7	similar	similar	JJ
cord-018804-wj35q88f	26	8	to	to	IN
cord-018804-wj35q88f	26	9	that	that	DT
cord-018804-wj35q88f	26	10	followed	follow	VBN
cord-018804-wj35q88f	26	11	by	by	IN
cord-018804-wj35q88f	26	12	cells	cell	NNS
cord-018804-wj35q88f	26	13	to	to	TO
cord-018804-wj35q88f	26	14	replicate	replicate	VB
cord-018804-wj35q88f	26	15	their	-PRON-	PRP$
cord-018804-wj35q88f	26	16	genomes	genome	NNS
cord-018804-wj35q88f	26	17	and	and	CC
cord-018804-wj35q88f	26	18	to	to	TO
cord-018804-wj35q88f	26	19	synthesize	synthesize	VB
cord-018804-wj35q88f	26	20	their	-PRON-	PRP$
cord-018804-wj35q88f	26	21	proteins	protein	NNS
cord-018804-wj35q88f	26	22	.	.	.
cord-018804-wj35q88f	27	1	However	however	RB
cord-018804-wj35q88f	27	2	,	,	,
cord-018804-wj35q88f	27	3	RNA	RNA	NNP
cord-018804-wj35q88f	27	4	viruses	virus	NNS
cord-018804-wj35q88f	27	5	need	need	VBP
cord-018804-wj35q88f	27	6	another	another	DT
cord-018804-wj35q88f	27	7	process	process	NN
cord-018804-wj35q88f	27	8	,	,	,
cord-018804-wj35q88f	27	9	RNA	RNA	NNP
cord-018804-wj35q88f	27	10	replication	replication	NN
cord-018804-wj35q88f	27	11	,	,	,
cord-018804-wj35q88f	27	12	which	which	WDT
cord-018804-wj35q88f	27	13	is	be	VBZ
cord-018804-wj35q88f	27	14	not	not	RB
cord-018804-wj35q88f	27	15	among	among	IN
cord-018804-wj35q88f	27	16	the	the	DT
cord-018804-wj35q88f	27	17	functions	function	NNS
cord-018804-wj35q88f	27	18	carried	carry	VBN
cord-018804-wj35q88f	27	19	out	out	RP
cord-018804-wj35q88f	27	20	routinely	routinely	RB
cord-018804-wj35q88f	27	21	in	in	IN
cord-018804-wj35q88f	27	22	the	the	DT
cord-018804-wj35q88f	27	23	cell	cell	NN
cord-018804-wj35q88f	27	24	[	[	-LRB-
cord-018804-wj35q88f	27	25	1	1	CD
cord-018804-wj35q88f	27	26	]	]	-RRB-
cord-018804-wj35q88f	27	27	.	.	.
cord-018804-wj35q88f	28	1	Therefore	therefore	RB
cord-018804-wj35q88f	28	2	,	,	,
cord-018804-wj35q88f	28	3	they	-PRON-	PRP
cord-018804-wj35q88f	28	4	have	have	VBP
cord-018804-wj35q88f	28	5	to	to	TO
cord-018804-wj35q88f	28	6	encode	encode	VB
cord-018804-wj35q88f	28	7	and	and	CC
cord-018804-wj35q88f	28	8	express	express	VB
cord-018804-wj35q88f	28	9	the	the	DT
cord-018804-wj35q88f	28	10	enzymatic	enzymatic	JJ
cord-018804-wj35q88f	28	11	activities	activity	NNS
cord-018804-wj35q88f	28	12	necessary	necessary	JJ
cord-018804-wj35q88f	28	13	to	to	TO
cord-018804-wj35q88f	28	14	copy	copy	VB
cord-018804-wj35q88f	28	15	their	-PRON-	PRP$
cord-018804-wj35q88f	28	16	genomes	genome	NNS
cord-018804-wj35q88f	28	17	.	.	.
cord-018804-wj35q88f	29	1	These	these	DT
cord-018804-wj35q88f	29	2	enzymes	enzyme	NNS
cord-018804-wj35q88f	29	3	are	be	VBP
cord-018804-wj35q88f	29	4	the	the	DT
cord-018804-wj35q88f	29	5	RNA	RNA	NNP
cord-018804-wj35q88f	29	6	replicases	replicase	NNS
cord-018804-wj35q88f	29	7	and	and	CC
cord-018804-wj35q88f	29	8	the	the	DT
cord-018804-wj35q88f	29	9	reverse	reverse	JJ
cord-018804-wj35q88f	29	10	transcriptases	transcriptase	NNS
cord-018804-wj35q88f	29	11	,	,	,
cord-018804-wj35q88f	29	12	which	which	WDT
cord-018804-wj35q88f	29	13	in	in	IN
cord-018804-wj35q88f	29	14	many	many	JJ
cord-018804-wj35q88f	29	15	cases	case	NNS
cord-018804-wj35q88f	29	16	are	be	VBP
cord-018804-wj35q88f	29	17	co	co	JJ
cord-018804-wj35q88f	29	18	-	-	VBN
cord-018804-wj35q88f	29	19	encapsidated	encapsidated	JJ
cord-018804-wj35q88f	29	20	with	with	IN
cord-018804-wj35q88f	29	21	the	the	DT
cord-018804-wj35q88f	29	22	nucleic	nucleic	JJ
cord-018804-wj35q88f	29	23	acid	acid	NN
cord-018804-wj35q88f	29	24	during	during	IN
cord-018804-wj35q88f	29	25	the	the	DT
cord-018804-wj35q88f	29	26	assembly	assembly	NN
cord-018804-wj35q88f	29	27	of	of	IN
cord-018804-wj35q88f	29	28	the	the	DT
cord-018804-wj35q88f	29	29	viral	viral	JJ
cord-018804-wj35q88f	29	30	particles	particle	NNS
cord-018804-wj35q88f	29	31	.	.	.
cord-018804-wj35q88f	30	1	In	in	IN
cord-018804-wj35q88f	30	2	this	this	DT
cord-018804-wj35q88f	30	3	way	way	NN
cord-018804-wj35q88f	30	4	,	,	,
cord-018804-wj35q88f	30	5	they	-PRON-	PRP
cord-018804-wj35q88f	30	6	are	be	VBP
cord-018804-wj35q88f	30	7	available	available	JJ
cord-018804-wj35q88f	30	8	at	at	IN
cord-018804-wj35q88f	30	9	the	the	DT
cord-018804-wj35q88f	30	10	start	start	NN
cord-018804-wj35q88f	30	11	of	of	IN
cord-018804-wj35q88f	30	12	the	the	DT
cord-018804-wj35q88f	30	13	infection	infection	NN
cord-018804-wj35q88f	30	14	.	.	.
cord-018804-wj35q88f	31	1	All	all	DT
cord-018804-wj35q88f	31	2	living	living	NN
cord-018804-wj35q88f	31	3	systems	system	NNS
cord-018804-wj35q88f	31	4	must	must	MD
cord-018804-wj35q88f	31	5	reach	reach	VB
cord-018804-wj35q88f	31	6	a	a	DT
cord-018804-wj35q88f	31	7	compromise	compromise	NN
cord-018804-wj35q88f	31	8	between	between	IN
cord-018804-wj35q88f	31	9	the	the	DT
cord-018804-wj35q88f	31	10	correct	correct	JJ
cord-018804-wj35q88f	31	11	copy	copy	NN
cord-018804-wj35q88f	31	12	of	of	IN
cord-018804-wj35q88f	31	13	the	the	DT
cord-018804-wj35q88f	31	14	nucleotide	nucleotide	JJ
cord-018804-wj35q88f	31	15	sequence	sequence	NN
cord-018804-wj35q88f	31	16	of	of	IN
cord-018804-wj35q88f	31	17	their	-PRON-	PRP$
cord-018804-wj35q88f	31	18	genomes	genome	NNS
cord-018804-wj35q88f	31	19	and	and	CC
cord-018804-wj35q88f	31	20	the	the	DT
cord-018804-wj35q88f	31	21	ability	ability	NN
cord-018804-wj35q88f	31	22	to	to	TO
cord-018804-wj35q88f	31	23	adapt	adapt	VB
cord-018804-wj35q88f	31	24	to	to	IN
cord-018804-wj35q88f	31	25	an	an	DT
cord-018804-wj35q88f	31	26	environment	environment	NN
cord-018804-wj35q88f	31	27	that	that	WDT
cord-018804-wj35q88f	31	28	is	be	VBZ
cord-018804-wj35q88f	31	29	continuously	continuously	RB
cord-018804-wj35q88f	31	30	changing	change	VBG
cord-018804-wj35q88f	31	31	[	[	-LRB-
cord-018804-wj35q88f	31	32	2	2	CD
cord-018804-wj35q88f	31	33	]	]	-RRB-
cord-018804-wj35q88f	31	34	.	.	.
cord-018804-wj35q88f	32	1	The	the	DT
cord-018804-wj35q88f	32	2	generation	generation	NN
cord-018804-wj35q88f	32	3	of	of	IN
cord-018804-wj35q88f	32	4	mutants	mutant	NNS
cord-018804-wj35q88f	32	5	upon	upon	IN
cord-018804-wj35q88f	32	6	replication	replication	NN
cord-018804-wj35q88f	32	7	provides	provide	VBZ
cord-018804-wj35q88f	32	8	the	the	DT
cord-018804-wj35q88f	32	9	necessary	necessary	JJ
cord-018804-wj35q88f	32	10	diversity	diversity	NN
cord-018804-wj35q88f	32	11	from	from	IN
cord-018804-wj35q88f	32	12	which	which	WDT
cord-018804-wj35q88f	32	13	natural	natural	JJ
cord-018804-wj35q88f	32	14	selection	selection	NN
cord-018804-wj35q88f	32	15	can	can	MD
cord-018804-wj35q88f	32	16	choose	choose	VB
cord-018804-wj35q88f	32	17	the	the	DT
cord-018804-wj35q88f	32	18	best	well	RBS
cord-018804-wj35q88f	32	19	adapted	adapt	VBN
cord-018804-wj35q88f	32	20	variants	variant	NNS
cord-018804-wj35q88f	32	21	in	in	IN
cord-018804-wj35q88f	32	22	a	a	DT
cord-018804-wj35q88f	32	23	concrete	concrete	JJ
cord-018804-wj35q88f	32	24	environment	environment	NN
cord-018804-wj35q88f	32	25	.	.	.
cord-018804-wj35q88f	33	1	The	the	DT
cord-018804-wj35q88f	33	2	observed	observed	JJ
cord-018804-wj35q88f	33	3	divergences	divergence	NNS
cord-018804-wj35q88f	33	4	among	among	IN
cord-018804-wj35q88f	33	5	mutation	mutation	NN
cord-018804-wj35q88f	33	6	rates	rate	NNS
cord-018804-wj35q88f	33	7	in	in	IN
cord-018804-wj35q88f	33	8	different	different	JJ
cord-018804-wj35q88f	33	9	species	specie	NNS
cord-018804-wj35q88f	33	10	suggest	suggest	VBP
cord-018804-wj35q88f	33	11	that	that	IN
cord-018804-wj35q88f	33	12	possibly	possibly	RB
cord-018804-wj35q88f	33	13	this	this	DT
cord-018804-wj35q88f	33	14	character	character	NN
cord-018804-wj35q88f	33	15	is	be	VBZ
cord-018804-wj35q88f	33	16	selected	select	VBN
cord-018804-wj35q88f	33	17	depending	depend	VBG
cord-018804-wj35q88f	33	18	on	on	IN
cord-018804-wj35q88f	33	19	the	the	DT
cord-018804-wj35q88f	33	20	variability	variability	NN
cord-018804-wj35q88f	33	21	of	of	IN
cord-018804-wj35q88f	33	22	the	the	DT
cord-018804-wj35q88f	33	23	environment	environment	NN
cord-018804-wj35q88f	33	24	[	[	-LRB-
cord-018804-wj35q88f	33	25	3	3	CD
cord-018804-wj35q88f	33	26	]	]	-RRB-
cord-018804-wj35q88f	33	27	.	.	.
cord-018804-wj35q88f	34	1	Cellular	cellular	JJ
cord-018804-wj35q88f	34	2	systems	system	NNS
cord-018804-wj35q88f	34	3	are	be	VBP
cord-018804-wj35q88f	34	4	able	able	JJ
cord-018804-wj35q88f	34	5	to	to	TO
cord-018804-wj35q88f	34	6	maintain	maintain	VB
cord-018804-wj35q88f	34	7	a	a	DT
cord-018804-wj35q88f	34	8	relative	relative	JJ
cord-018804-wj35q88f	34	9	constancy	constancy	NN
cord-018804-wj35q88f	34	10	in	in	IN
cord-018804-wj35q88f	34	11	the	the	DT
cord-018804-wj35q88f	34	12	intra	intra	JJ
cord-018804-wj35q88f	34	13	-	-	JJ
cord-018804-wj35q88f	34	14	cytoplasmatic	cytoplasmatic	JJ
cord-018804-wj35q88f	34	15	medium	medium	NN
cord-018804-wj35q88f	34	16	and	and	CC
cord-018804-wj35q88f	34	17	because	because	IN
cord-018804-wj35q88f	34	18	of	of	IN
cord-018804-wj35q88f	34	19	that	that	DT
cord-018804-wj35q88f	34	20	,	,	,
cord-018804-wj35q88f	34	21	they	-PRON-	PRP
cord-018804-wj35q88f	34	22	do	do	VBP
cord-018804-wj35q88f	34	23	not	not	RB
cord-018804-wj35q88f	34	24	need	need	VB
cord-018804-wj35q88f	34	25	a	a	DT
cord-018804-wj35q88f	34	26	high	high	JJ
cord-018804-wj35q88f	34	27	genetic	genetic	JJ
cord-018804-wj35q88f	34	28	variability	variability	NN
cord-018804-wj35q88f	34	29	.	.	.
cord-018804-wj35q88f	35	1	Thus	thus	RB
cord-018804-wj35q88f	35	2	,	,	,
cord-018804-wj35q88f	35	3	evolution	evolution	NN
cord-018804-wj35q88f	35	4	has	have	VBZ
cord-018804-wj35q88f	35	5	emphasized	emphasize	VBN
cord-018804-wj35q88f	35	6	the	the	DT
cord-018804-wj35q88f	35	7	selection	selection	NN
cord-018804-wj35q88f	35	8	of	of	IN
cord-018804-wj35q88f	35	9	a	a	DT
cord-018804-wj35q88f	35	10	replicative	replicative	JJ
cord-018804-wj35q88f	35	11	machinery	machinery	NN
cord-018804-wj35q88f	35	12	with	with	IN
cord-018804-wj35q88f	35	13	several	several	JJ
cord-018804-wj35q88f	35	14	corrector	corrector	NN
cord-018804-wj35q88f	35	15	activities	activity	NNS
cord-018804-wj35q88f	35	16	that	that	WDT
cord-018804-wj35q88f	35	17	permit	permit	VBP
cord-018804-wj35q88f	35	18	a	a	DT
cord-018804-wj35q88f	35	19	high	high	JJ
cord-018804-wj35q88f	35	20	copying	copying	NN
cord-018804-wj35q88f	35	21	accuracy	accuracy	NN
cord-018804-wj35q88f	35	22	.	.	.
cord-018804-wj35q88f	36	1	However	however	RB
cord-018804-wj35q88f	36	2	,	,	,
cord-018804-wj35q88f	36	3	even	even	RB
cord-018804-wj35q88f	36	4	in	in	IN
cord-018804-wj35q88f	36	5	the	the	DT
cord-018804-wj35q88f	36	6	cellular	cellular	JJ
cord-018804-wj35q88f	36	7	world	world	NN
cord-018804-wj35q88f	36	8	,	,	,
cord-018804-wj35q88f	36	9	mutation	mutation	NN
cord-018804-wj35q88f	36	10	rate	rate	NN
cord-018804-wj35q88f	36	11	is	be	VBZ
cord-018804-wj35q88f	36	12	not	not	RB
cord-018804-wj35q88f	36	13	a	a	DT
cord-018804-wj35q88f	36	14	fixed	fix	VBN
cord-018804-wj35q88f	36	15	character	character	NN
cord-018804-wj35q88f	36	16	that	that	WDT
cord-018804-wj35q88f	36	17	can	can	MD
cord-018804-wj35q88f	36	18	not	not	RB
cord-018804-wj35q88f	36	19	be	be	VB
cord-018804-wj35q88f	36	20	altered	alter	VBN
cord-018804-wj35q88f	36	21	.	.	.
cord-018804-wj35q88f	37	1	It	-PRON-	PRP
cord-018804-wj35q88f	37	2	can	can	MD
cord-018804-wj35q88f	37	3	be	be	VB
cord-018804-wj35q88f	37	4	modified	modify	VBN
cord-018804-wj35q88f	37	5	in	in	IN
cord-018804-wj35q88f	37	6	response	response	NN
cord-018804-wj35q88f	37	7	to	to	IN
cord-018804-wj35q88f	37	8	environmental	environmental	JJ
cord-018804-wj35q88f	37	9	changes	change	NNS
cord-018804-wj35q88f	37	10	by	by	IN
cord-018804-wj35q88f	37	11	selection	selection	NN
cord-018804-wj35q88f	37	12	of	of	IN
cord-018804-wj35q88f	37	13	variants	variant	NNS
cord-018804-wj35q88f	37	14	with	with	IN
cord-018804-wj35q88f	37	15	higher	high	JJR
cord-018804-wj35q88f	37	16	or	or	CC
cord-018804-wj35q88f	37	17	lower	low	JJR
cord-018804-wj35q88f	37	18	error	error	NN
cord-018804-wj35q88f	37	19	rates	rate	NNS
cord-018804-wj35q88f	37	20	.	.	.
cord-018804-wj35q88f	38	1	The	the	DT
cord-018804-wj35q88f	38	2	isolation	isolation	NN
cord-018804-wj35q88f	38	3	of	of	IN
cord-018804-wj35q88f	38	4	hypermutator	hypermutator	NN
cord-018804-wj35q88f	38	5	strains	strain	NNS
cord-018804-wj35q88f	38	6	,	,	,
cord-018804-wj35q88f	38	7	which	which	WDT
cord-018804-wj35q88f	38	8	show	show	VBP
cord-018804-wj35q88f	38	9	deficiencies	deficiency	NNS
cord-018804-wj35q88f	38	10	in	in	IN
cord-018804-wj35q88f	38	11	some	some	DT
cord-018804-wj35q88f	38	12	of	of	IN
cord-018804-wj35q88f	38	13	the	the	DT
cord-018804-wj35q88f	38	14	polymerase	polymerase	NN
cord-018804-wj35q88f	38	15	corrector	corrector	NN
cord-018804-wj35q88f	38	16	activities	activity	NNS
cord-018804-wj35q88f	38	17	,	,	,
cord-018804-wj35q88f	38	18	is	be	VBZ
cord-018804-wj35q88f	38	19	frequent	frequent	JJ
cord-018804-wj35q88f	38	20	in	in	IN
cord-018804-wj35q88f	38	21	conditions	condition	NNS
cord-018804-wj35q88f	38	22	of	of	IN
cord-018804-wj35q88f	38	23	environmental	environmental	JJ
cord-018804-wj35q88f	38	24	stress	stress	NN
cord-018804-wj35q88f	38	25	and	and	CC
cord-018804-wj35q88f	38	26	is	be	VBZ
cord-018804-wj35q88f	38	27	a	a	DT
cord-018804-wj35q88f	38	28	proof	proof	NN
cord-018804-wj35q88f	38	29	of	of	IN
cord-018804-wj35q88f	38	30	the	the	DT
cord-018804-wj35q88f	38	31	versatility	versatility	NN
cord-018804-wj35q88f	38	32	of	of	IN
cord-018804-wj35q88f	38	33	mutability	mutability	NN
cord-018804-wj35q88f	38	34	as	as	IN
cord-018804-wj35q88f	38	35	a	a	DT
cord-018804-wj35q88f	38	36	character	character	NN
cord-018804-wj35q88f	38	37	that	that	WDT
cord-018804-wj35q88f	38	38	can	can	MD
cord-018804-wj35q88f	38	39	be	be	VB
cord-018804-wj35q88f	38	40	modified	modify	VBN
cord-018804-wj35q88f	38	41	when	when	WRB
cord-018804-wj35q88f	38	42	the	the	DT
cord-018804-wj35q88f	38	43	environment	environment	NN
cord-018804-wj35q88f	38	44	requires	require	VBZ
cord-018804-wj35q88f	38	45	it	-PRON-	PRP
cord-018804-wj35q88f	38	46	[	[	-LRB-
cord-018804-wj35q88f	38	47	4	4	CD
cord-018804-wj35q88f	38	48	,	,	,
cord-018804-wj35q88f	38	49	5	5	CD
cord-018804-wj35q88f	38	50	]	]	-RRB-
cord-018804-wj35q88f	38	51	.	.	.
cord-018804-wj35q88f	39	1	A	a	DT
cord-018804-wj35q88f	39	2	relevant	relevant	JJ
cord-018804-wj35q88f	39	3	characteristic	characteristic	NN
cord-018804-wj35q88f	39	4	of	of	IN
cord-018804-wj35q88f	39	5	RNA	RNA	NNP
cord-018804-wj35q88f	39	6	viruses	virus	NNS
cord-018804-wj35q88f	39	7	is	be	VBZ
cord-018804-wj35q88f	39	8	that	that	IN
cord-018804-wj35q88f	39	9	they	-PRON-	PRP
cord-018804-wj35q88f	39	10	replicate	replicate	VBP
cord-018804-wj35q88f	39	11	their	-PRON-	PRP$
cord-018804-wj35q88f	39	12	genomes	genome	NNS
cord-018804-wj35q88f	39	13	with	with	IN
cord-018804-wj35q88f	39	14	a	a	DT
cord-018804-wj35q88f	39	15	copying	copying	NN
cord-018804-wj35q88f	39	16	fidelity	fidelity	NN
cord-018804-wj35q88f	39	17	several	several	JJ
cord-018804-wj35q88f	39	18	orders	order	NNS
cord-018804-wj35q88f	39	19	of	of	IN
cord-018804-wj35q88f	39	20	magnitude	magnitude	NN
cord-018804-wj35q88f	39	21	lower	low	JJR
cord-018804-wj35q88f	39	22	than	than	IN
cord-018804-wj35q88f	39	23	cellular	cellular	JJ
cord-018804-wj35q88f	39	24	DNA	dna	NN
cord-018804-wj35q88f	39	25	[	[	-LRB-
cord-018804-wj35q88f	39	26	6	6	CD
cord-018804-wj35q88f	39	27	]	]	-RRB-
cord-018804-wj35q88f	39	28	.	.	.
cord-018804-wj35q88f	40	1	This	this	DT
cord-018804-wj35q88f	40	2	fact	fact	NN
cord-018804-wj35q88f	40	3	has	have	VBZ
cord-018804-wj35q88f	40	4	been	be	VBN
cord-018804-wj35q88f	40	5	interpreted	interpret	VBN
cord-018804-wj35q88f	40	6	as	as	IN
cord-018804-wj35q88f	40	7	a	a	DT
cord-018804-wj35q88f	40	8	consequence	consequence	NN
cord-018804-wj35q88f	40	9	of	of	IN
cord-018804-wj35q88f	40	10	the	the	DT
cord-018804-wj35q88f	40	11	fluctuating	fluctuate	VBG
cord-018804-wj35q88f	40	12	environments	environment	NNS
cord-018804-wj35q88f	40	13	that	that	WDT
cord-018804-wj35q88f	40	14	viruses	virus	NNS
cord-018804-wj35q88f	40	15	have	have	VBP
cord-018804-wj35q88f	40	16	to	to	TO
cord-018804-wj35q88f	40	17	face	face	VB
cord-018804-wj35q88f	40	18	.	.	.
cord-018804-wj35q88f	41	1	High	high	JJ
cord-018804-wj35q88f	41	2	error	error	NN
cord-018804-wj35q88f	41	3	prone	prone	JJ
cord-018804-wj35q88f	41	4	replication	replication	NN
cord-018804-wj35q88f	41	5	,	,	,
cord-018804-wj35q88f	41	6	together	together	RB
cord-018804-wj35q88f	41	7	with	with	IN
cord-018804-wj35q88f	41	8	the	the	DT
cord-018804-wj35q88f	41	9	short	short	JJ
cord-018804-wj35q88f	41	10	replication	replication	NN
cord-018804-wj35q88f	41	11	times	time	NNS
cord-018804-wj35q88f	41	12	and	and	CC
cord-018804-wj35q88f	41	13	large	large	JJ
cord-018804-wj35q88f	41	14	population	population	NN
cord-018804-wj35q88f	41	15	sizes	size	NNS
cord-018804-wj35q88f	41	16	typical	typical	JJ
cord-018804-wj35q88f	41	17	of	of	IN
cord-018804-wj35q88f	41	18	RNA	RNA	NNP
cord-018804-wj35q88f	41	19	viruses	virus	NNS
cord-018804-wj35q88f	41	20	,	,	,
cord-018804-wj35q88f	41	21	instead	instead	RB
cord-018804-wj35q88f	41	22	of	of	IN
cord-018804-wj35q88f	41	23	being	be	VBG
cord-018804-wj35q88f	41	24	a	a	DT
cord-018804-wj35q88f	41	25	handicap	handicap	NN
cord-018804-wj35q88f	41	26	for	for	IN
cord-018804-wj35q88f	41	27	survival	survival	NN
cord-018804-wj35q88f	41	28	provides	provide	VBZ
cord-018804-wj35q88f	41	29	an	an	DT
cord-018804-wj35q88f	41	30	extraordinary	extraordinary	JJ
cord-018804-wj35q88f	41	31	evolutionary	evolutionary	JJ
cord-018804-wj35q88f	41	32	advantage	advantage	NN
cord-018804-wj35q88f	41	33	by	by	IN
cord-018804-wj35q88f	41	34	permitting	permit	VBG
cord-018804-wj35q88f	41	35	the	the	DT
cord-018804-wj35q88f	41	36	generation	generation	NN
cord-018804-wj35q88f	41	37	of	of	IN
cord-018804-wj35q88f	41	38	a	a	DT
cord-018804-wj35q88f	41	39	wide	wide	JJ
cord-018804-wj35q88f	41	40	reservoir	reservoir	NN
cord-018804-wj35q88f	41	41	of	of	IN
cord-018804-wj35q88f	41	42	mutants	mutant	NNS
cord-018804-wj35q88f	41	43	with	with	IN
cord-018804-wj35q88f	41	44	different	different	JJ
cord-018804-wj35q88f	41	45	phenotypic	phenotypic	JJ
cord-018804-wj35q88f	41	46	properties	property	NNS
cord-018804-wj35q88f	41	47	[	[	-LRB-
cord-018804-wj35q88f	41	48	7	7	CD
cord-018804-wj35q88f	41	49	]	]	-RRB-
cord-018804-wj35q88f	41	50	.	.	.
cord-018804-wj35q88f	42	1	The	the	DT
cord-018804-wj35q88f	42	2	high	high	JJ
cord-018804-wj35q88f	42	3	variability	variability	NN
cord-018804-wj35q88f	42	4	of	of	IN
cord-018804-wj35q88f	42	5	RNA	RNA	NNP
cord-018804-wj35q88f	42	6	viruses	virus	NNS
cord-018804-wj35q88f	42	7	facilitates	facilitate	VBZ
cord-018804-wj35q88f	42	8	their	-PRON-	PRP$
cord-018804-wj35q88f	42	9	survival	survival	NN
cord-018804-wj35q88f	42	10	in	in	IN
cord-018804-wj35q88f	42	11	presence	presence	NN
cord-018804-wj35q88f	42	12	of	of	IN
cord-018804-wj35q88f	42	13	antibodies	antibody	NNS
cord-018804-wj35q88f	42	14	and	and	CC
cord-018804-wj35q88f	42	15	other	other	JJ
cord-018804-wj35q88f	42	16	defence	defence	NN
cord-018804-wj35q88f	42	17	mechanisms	mechanism	NNS
cord-018804-wj35q88f	42	18	produced	produce	VBN
cord-018804-wj35q88f	42	19	by	by	IN
cord-018804-wj35q88f	42	20	the	the	DT
cord-018804-wj35q88f	42	21	immune	immune	JJ
cord-018804-wj35q88f	42	22	system	system	NN
cord-018804-wj35q88f	42	23	of	of	IN
cord-018804-wj35q88f	42	24	the	the	DT
cord-018804-wj35q88f	42	25	host	host	NN
cord-018804-wj35q88f	42	26	.	.	.
cord-018804-wj35q88f	43	1	It	-PRON-	PRP
cord-018804-wj35q88f	43	2	also	also	RB
cord-018804-wj35q88f	43	3	makes	make	VBZ
cord-018804-wj35q88f	43	4	possible	possible	JJ
cord-018804-wj35q88f	43	5	the	the	DT
cord-018804-wj35q88f	43	6	acquisition	acquisition	NN
cord-018804-wj35q88f	43	7	of	of	IN
cord-018804-wj35q88f	43	8	novel	novel	JJ
cord-018804-wj35q88f	43	9	pathogenic	pathogenic	JJ
cord-018804-wj35q88f	43	10	properties	property	NNS
cord-018804-wj35q88f	43	11	that	that	WDT
cord-018804-wj35q88f	43	12	in	in	IN
cord-018804-wj35q88f	43	13	occasions	occasion	NNS
cord-018804-wj35q88f	43	14	have	have	VBP
cord-018804-wj35q88f	43	15	allowed	allow	VBN
cord-018804-wj35q88f	43	16	to	to	TO
cord-018804-wj35q88f	43	17	cross	cross	VB
cord-018804-wj35q88f	43	18	species	species	NN
cord-018804-wj35q88f	43	19	boundaries	boundary	NNS
cord-018804-wj35q88f	43	20	favouring	favour	VBG
cord-018804-wj35q88f	43	21	the	the	DT
cord-018804-wj35q88f	43	22	infection	infection	NN
cord-018804-wj35q88f	43	23	of	of	IN
cord-018804-wj35q88f	43	24	alternative	alternative	JJ
cord-018804-wj35q88f	43	25	hosts	host	NNS
cord-018804-wj35q88f	43	26	[	[	-LRB-
cord-018804-wj35q88f	43	27	8	8	CD
cord-018804-wj35q88f	43	28	,	,	,
cord-018804-wj35q88f	43	29	9	9	CD
cord-018804-wj35q88f	43	30	]	]	-RRB-
cord-018804-wj35q88f	43	31	.	.	.
cord-018804-wj35q88f	44	1	Finally	finally	RB
cord-018804-wj35q88f	44	2	,	,	,
cord-018804-wj35q88f	44	3	the	the	DT
cord-018804-wj35q88f	44	4	heterogeneity	heterogeneity	NN
cord-018804-wj35q88f	44	5	of	of	IN
cord-018804-wj35q88f	44	6	RNA	RNA	NNP
cord-018804-wj35q88f	44	7	virus	virus	NN
cord-018804-wj35q88f	44	8	populations	population	NNS
cord-018804-wj35q88f	44	9	makes	make	VBZ
cord-018804-wj35q88f	44	10	it	-PRON-	PRP
cord-018804-wj35q88f	44	11	also	also	RB
cord-018804-wj35q88f	44	12	difficult	difficult	JJ
cord-018804-wj35q88f	44	13	to	to	TO
cord-018804-wj35q88f	44	14	eradicate	eradicate	VB
cord-018804-wj35q88f	44	15	diseases	disease	NNS
cord-018804-wj35q88f	44	16	with	with	IN
cord-018804-wj35q88f	44	17	antiviral	antiviral	JJ
cord-018804-wj35q88f	44	18	drugs	drug	NNS
cord-018804-wj35q88f	44	19	,	,	,
cord-018804-wj35q88f	44	20	due	due	IN
cord-018804-wj35q88f	44	21	to	to	IN
cord-018804-wj35q88f	44	22	the	the	DT
cord-018804-wj35q88f	44	23	emergence	emergence	NN
cord-018804-wj35q88f	44	24	of	of	IN
cord-018804-wj35q88f	44	25	drug	drug	NN
cord-018804-wj35q88f	44	26	-	-	HYPH
cord-018804-wj35q88f	44	27	resistant	resistant	JJ
cord-018804-wj35q88f	44	28	mutants	mutant	NNS
cord-018804-wj35q88f	44	29	[	[	-LRB-
cord-018804-wj35q88f	44	30	10	10	CD
cord-018804-wj35q88f	44	31	]	]	-RRB-
cord-018804-wj35q88f	44	32	,	,	,
cord-018804-wj35q88f	44	33	a	a	DT
cord-018804-wj35q88f	44	34	problem	problem	NN
cord-018804-wj35q88f	44	35	that	that	WDT
cord-018804-wj35q88f	44	36	will	will	MD
cord-018804-wj35q88f	44	37	be	be	VB
cord-018804-wj35q88f	44	38	treated	treat	VBN
cord-018804-wj35q88f	44	39	in	in	IN
cord-018804-wj35q88f	44	40	more	more	JJR
cord-018804-wj35q88f	44	41	detail	detail	NN
cord-018804-wj35q88f	44	42	in	in	IN
cord-018804-wj35q88f	44	43	the	the	DT
cord-018804-wj35q88f	44	44	next	next	JJ
cord-018804-wj35q88f	44	45	sections	section	NNS
cord-018804-wj35q88f	44	46	.	.	.
cord-018804-wj35q88f	45	1	Whether	whether	IN
cord-018804-wj35q88f	45	2	the	the	DT
cord-018804-wj35q88f	45	3	high	high	JJ
cord-018804-wj35q88f	45	4	genetic	genetic	JJ
cord-018804-wj35q88f	45	5	variability	variability	NN
cord-018804-wj35q88f	45	6	of	of	IN
cord-018804-wj35q88f	45	7	RNA	RNA	NNP
cord-018804-wj35q88f	45	8	viruses	virus	NNS
cord-018804-wj35q88f	45	9	is	be	VBZ
cord-018804-wj35q88f	45	10	a	a	DT
cord-018804-wj35q88f	45	11	selected	select	VBN
cord-018804-wj35q88f	45	12	character	character	NN
cord-018804-wj35q88f	45	13	,	,	,
cord-018804-wj35q88f	45	14	necessary	necessary	JJ
cord-018804-wj35q88f	45	15	for	for	IN
cord-018804-wj35q88f	45	16	survival	survival	NN
cord-018804-wj35q88f	45	17	in	in	IN
cord-018804-wj35q88f	45	18	high	high	JJ
cord-018804-wj35q88f	45	19	fluctuating	fluctuate	VBG
cord-018804-wj35q88f	45	20	environments	environment	NNS
cord-018804-wj35q88f	45	21	,	,	,
cord-018804-wj35q88f	45	22	or	or	CC
cord-018804-wj35q88f	45	23	it	-PRON-	PRP
cord-018804-wj35q88f	45	24	is	be	VBZ
cord-018804-wj35q88f	45	25	simply	simply	RB
cord-018804-wj35q88f	45	26	a	a	DT
cord-018804-wj35q88f	45	27	consequence	consequence	NN
cord-018804-wj35q88f	45	28	of	of	IN
cord-018804-wj35q88f	45	29	the	the	DT
cord-018804-wj35q88f	45	30	lack	lack	NN
cord-018804-wj35q88f	45	31	of	of	IN
cord-018804-wj35q88f	45	32	corrector	corrector	NN
cord-018804-wj35q88f	45	33	activities	activity	NNS
cord-018804-wj35q88f	45	34	of	of	IN
cord-018804-wj35q88f	45	35	RNA	RNA	NNP
cord-018804-wj35q88f	45	36	replicases	replicase	NNS
cord-018804-wj35q88f	45	37	and	and	CC
cord-018804-wj35q88f	45	38	reverse	reverse	VB
cord-018804-wj35q88f	45	39	transcriptases	transcriptase	NNS
cord-018804-wj35q88f	45	40	is	be	VBZ
cord-018804-wj35q88f	45	41	a	a	DT
cord-018804-wj35q88f	45	42	debated	debate	VBN
cord-018804-wj35q88f	45	43	question	question	NN
cord-018804-wj35q88f	45	44	.	.	.
cord-018804-wj35q88f	46	1	However	however	RB
cord-018804-wj35q88f	46	2	,	,	,
cord-018804-wj35q88f	46	3	the	the	DT
cord-018804-wj35q88f	46	4	fact	fact	NN
cord-018804-wj35q88f	46	5	that	that	IN
cord-018804-wj35q88f	46	6	DNA	dna	NN
cord-018804-wj35q88f	46	7	organisms	organism	NNS
cord-018804-wj35q88f	46	8	,	,	,
cord-018804-wj35q88f	46	9	which	which	WDT
cord-018804-wj35q88f	46	10	usually	usually	RB
cord-018804-wj35q88f	46	11	live	live	VBP
cord-018804-wj35q88f	46	12	in	in	IN
cord-018804-wj35q88f	46	13	constant	constant	JJ
cord-018804-wj35q88f	46	14	environments	environment	NNS
cord-018804-wj35q88f	46	15	,	,	,
cord-018804-wj35q88f	46	16	have	have	VBP
cord-018804-wj35q88f	46	17	evolved	evolve	VBN
cord-018804-wj35q88f	46	18	corrector	corrector	NN
cord-018804-wj35q88f	46	19	activities	activity	NNS
cord-018804-wj35q88f	46	20	,	,	,
cord-018804-wj35q88f	46	21	whereas	whereas	IN
cord-018804-wj35q88f	46	22	RNA	RNA	NNP
cord-018804-wj35q88f	46	23	viruses	virus	NNS
cord-018804-wj35q88f	46	24	have	have	VBP
cord-018804-wj35q88f	46	25	not	not	RB
cord-018804-wj35q88f	46	26	,	,	,
cord-018804-wj35q88f	46	27	suggests	suggest	VBZ
cord-018804-wj35q88f	46	28	that	that	IN
cord-018804-wj35q88f	46	29	replication	replication	NN
cord-018804-wj35q88f	46	30	with	with	IN
cord-018804-wj35q88f	46	31	high	high	JJ
cord-018804-wj35q88f	46	32	error	error	NN
cord-018804-wj35q88f	46	33	rates	rate	NNS
cord-018804-wj35q88f	46	34	is	be	VBZ
cord-018804-wj35q88f	46	35	a	a	DT
cord-018804-wj35q88f	46	36	selected	select	VBN
cord-018804-wj35q88f	46	37	character	character	NN
cord-018804-wj35q88f	46	38	that	that	WDT
cord-018804-wj35q88f	46	39	strongly	strongly	RB
cord-018804-wj35q88f	46	40	favours	favour	VBZ
cord-018804-wj35q88f	46	41	viral	viral	JJ
cord-018804-wj35q88f	46	42	adaptation	adaptation	NN
cord-018804-wj35q88f	46	43	to	to	TO
cord-018804-wj35q88f	46	44	fast	fast	VB
cord-018804-wj35q88f	46	45	changing	change	VBG
cord-018804-wj35q88f	46	46	conditions	condition	NNS
cord-018804-wj35q88f	46	47	.	.	.
cord-018804-wj35q88f	47	1	The	the	DT
cord-018804-wj35q88f	47	2	first	first	JJ
cord-018804-wj35q88f	47	3	requisite	requisite	NN
cord-018804-wj35q88f	47	4	for	for	IN
cord-018804-wj35q88f	47	5	the	the	DT
cord-018804-wj35q88f	47	6	evolution	evolution	NN
cord-018804-wj35q88f	47	7	of	of	IN
cord-018804-wj35q88f	47	8	any	any	DT
cord-018804-wj35q88f	47	9	population	population	NN
cord-018804-wj35q88f	47	10	is	be	VBZ
cord-018804-wj35q88f	47	11	the	the	DT
cord-018804-wj35q88f	47	12	generation	generation	NN
cord-018804-wj35q88f	47	13	of	of	IN
cord-018804-wj35q88f	47	14	a	a	DT
cord-018804-wj35q88f	47	15	significantly	significantly	RB
cord-018804-wj35q88f	47	16	wide	wide	JJ
cord-018804-wj35q88f	47	17	genetic	genetic	JJ
cord-018804-wj35q88f	47	18	diversity	diversity	NN
cord-018804-wj35q88f	47	19	on	on	IN
cord-018804-wj35q88f	47	20	which	which	WDT
cord-018804-wj35q88f	47	21	natural	natural	JJ
cord-018804-wj35q88f	47	22	selection	selection	NN
cord-018804-wj35q88f	47	23	and	and	CC
cord-018804-wj35q88f	47	24	genetic	genetic	JJ
cord-018804-wj35q88f	47	25	drift	drift	NN
cord-018804-wj35q88f	47	26	can	can	MD
cord-018804-wj35q88f	47	27	act	act	VB
cord-018804-wj35q88f	47	28	to	to	TO
cord-018804-wj35q88f	47	29	shape	shape	VB
cord-018804-wj35q88f	47	30	the	the	DT
cord-018804-wj35q88f	47	31	properties	property	NNS
cord-018804-wj35q88f	47	32	of	of	IN
cord-018804-wj35q88f	47	33	the	the	DT
cord-018804-wj35q88f	47	34	new	new	JJ
cord-018804-wj35q88f	47	35	populations	population	NNS
cord-018804-wj35q88f	47	36	generated	generate	VBN
cord-018804-wj35q88f	47	37	at	at	IN
cord-018804-wj35q88f	47	38	subsequent	subsequent	JJ
cord-018804-wj35q88f	47	39	generations	generation	NNS
cord-018804-wj35q88f	47	40	.	.	.
cord-018804-wj35q88f	48	1	The	the	DT
cord-018804-wj35q88f	48	2	genetic	genetic	JJ
cord-018804-wj35q88f	48	3	variation	variation	NN
cord-018804-wj35q88f	48	4	attained	attain	VBN
cord-018804-wj35q88f	48	5	by	by	IN
cord-018804-wj35q88f	48	6	RNA	RNA	NNP
cord-018804-wj35q88f	48	7	viruses	virus	NNS
cord-018804-wj35q88f	48	8	is	be	VBZ
cord-018804-wj35q88f	48	9	mainly	mainly	RB
cord-018804-wj35q88f	48	10	the	the	DT
cord-018804-wj35q88f	48	11	result	result	NN
cord-018804-wj35q88f	48	12	of	of	IN
cord-018804-wj35q88f	48	13	mutation	mutation	NN
cord-018804-wj35q88f	48	14	and	and	CC
cord-018804-wj35q88f	48	15	recombination	recombination	NN
cord-018804-wj35q88f	48	16	,	,	,
cord-018804-wj35q88f	48	17	two	two	CD
cord-018804-wj35q88f	48	18	processes	process	NNS
cord-018804-wj35q88f	48	19	that	that	WDT
cord-018804-wj35q88f	48	20	are	be	VBP
cord-018804-wj35q88f	48	21	dependent	dependent	JJ
cord-018804-wj35q88f	48	22	on	on	IN
cord-018804-wj35q88f	48	23	the	the	DT
cord-018804-wj35q88f	48	24	properties	property	NNS
cord-018804-wj35q88f	48	25	of	of	IN
cord-018804-wj35q88f	48	26	the	the	DT
cord-018804-wj35q88f	48	27	enzymes	enzyme	NNS
cord-018804-wj35q88f	48	28	that	that	WDT
cord-018804-wj35q88f	48	29	replicate	replicate	VBP
cord-018804-wj35q88f	48	30	their	-PRON-	PRP$
cord-018804-wj35q88f	48	31	genomes	genome	NNS
cord-018804-wj35q88f	48	32	.	.	.
cord-018804-wj35q88f	49	1	Genome	genome	NN
cord-018804-wj35q88f	49	2	segment	segment	NN
cord-018804-wj35q88f	49	3	reassortment	reassortment	NN
cord-018804-wj35q88f	49	4	occurs	occur	VBZ
cord-018804-wj35q88f	49	5	during	during	IN
cord-018804-wj35q88f	49	6	encapsidation	encapsidation	NN
cord-018804-wj35q88f	49	7	and	and	CC
cord-018804-wj35q88f	49	8	can	can	MD
cord-018804-wj35q88f	49	9	add	add	VB
cord-018804-wj35q88f	49	10	extra	extra	JJ
cord-018804-wj35q88f	49	11	variability	variability	NN
cord-018804-wj35q88f	49	12	in	in	IN
cord-018804-wj35q88f	49	13	the	the	DT
cord-018804-wj35q88f	49	14	case	case	NN
cord-018804-wj35q88f	49	15	of	of	IN
cord-018804-wj35q88f	49	16	viruses	virus	NNS
cord-018804-wj35q88f	49	17	with	with	IN
cord-018804-wj35q88f	49	18	segmented	segmented	JJ
cord-018804-wj35q88f	49	19	genomes	genome	NNS
cord-018804-wj35q88f	49	20	.	.	.
cord-018804-wj35q88f	50	1	The	the	DT
cord-018804-wj35q88f	50	2	replication	replication	NN
cord-018804-wj35q88f	50	3	of	of	IN
cord-018804-wj35q88f	50	4	RNA	RNA	NNP
cord-018804-wj35q88f	50	5	viruses	virus	NNS
cord-018804-wj35q88f	50	6	takes	take	VBZ
cord-018804-wj35q88f	50	7	place	place	NN
cord-018804-wj35q88f	50	8	through	through	IN
cord-018804-wj35q88f	50	9	two	two	CD
cord-018804-wj35q88f	50	10	main	main	JJ
cord-018804-wj35q88f	50	11	mechanisms	mechanism	NNS
cord-018804-wj35q88f	50	12	that	that	WDT
cord-018804-wj35q88f	50	13	involve	involve	VBP
cord-018804-wj35q88f	50	14	the	the	DT
cord-018804-wj35q88f	50	15	use	use	NN
cord-018804-wj35q88f	50	16	of	of	IN
cord-018804-wj35q88f	50	17	different	different	JJ
cord-018804-wj35q88f	50	18	enzymatic	enzymatic	JJ
cord-018804-wj35q88f	50	19	activities	activity	NNS
cord-018804-wj35q88f	50	20	[	[	-LRB-
cord-018804-wj35q88f	50	21	1	1	CD
cord-018804-wj35q88f	50	22	]	]	-RRB-
cord-018804-wj35q88f	50	23	.	.	.
cord-018804-wj35q88f	51	1	Riboviruses	Riboviruses	NNP
cord-018804-wj35q88f	51	2	,	,	,
cord-018804-wj35q88f	51	3	including	include	VBG
cord-018804-wj35q88f	51	4	many	many	JJ
cord-018804-wj35q88f	51	5	prokaryotic	prokaryotic	JJ
cord-018804-wj35q88f	51	6	RNA	RNA	NNP
cord-018804-wj35q88f	51	7	viruses	virus	NNS
cord-018804-wj35q88f	51	8	as	as	RB
cord-018804-wj35q88f	51	9	well	well	RB
cord-018804-wj35q88f	51	10	as	as	IN
cord-018804-wj35q88f	51	11	many	many	JJ
cord-018804-wj35q88f	51	12	animal	animal	NN
cord-018804-wj35q88f	51	13	and	and	CC
cord-018804-wj35q88f	51	14	plant	plant	NN
cord-018804-wj35q88f	51	15	viruses	virus	NNS
cord-018804-wj35q88f	51	16	(	(	-LRB-
cord-018804-wj35q88f	51	17	poliovirus	poliovirus	NN
cord-018804-wj35q88f	51	18	,	,	,
cord-018804-wj35q88f	51	19	influenza	influenza	NN
cord-018804-wj35q88f	51	20	virus	virus	NN
cord-018804-wj35q88f	51	21	,	,	,
cord-018804-wj35q88f	51	22	hepatitis	hepatitis	NNP
cord-018804-wj35q88f	51	23	A	A	NNP
cord-018804-wj35q88f	51	24	and	and	CC
cord-018804-wj35q88f	51	25	C	c	NN
cord-018804-wj35q88f	51	26	viruses	virus	NNS
cord-018804-wj35q88f	51	27	,	,	,
cord-018804-wj35q88f	51	28	etc	etc	FW
cord-018804-wj35q88f	51	29	.	.	.
cord-018804-wj35q88f	51	30	)	)	-RRB-
cord-018804-wj35q88f	51	31	,	,	,
cord-018804-wj35q88f	51	32	replicate	replicate	VBP
cord-018804-wj35q88f	51	33	their	-PRON-	PRP$
cord-018804-wj35q88f	51	34	genomes	genome	NNS
cord-018804-wj35q88f	51	35	using	use	VBG
cord-018804-wj35q88f	51	36	RNA	RNA	NNP
cord-018804-wj35q88f	51	37	replicases	replicase	NNS
cord-018804-wj35q88f	51	38	that	that	WDT
cord-018804-wj35q88f	51	39	catalyze	catalyze	VBP
cord-018804-wj35q88f	51	40	the	the	DT
cord-018804-wj35q88f	51	41	RNA	RNA	NNP
cord-018804-wj35q88f	51	42	-	-	HYPH
cord-018804-wj35q88f	51	43	dependent	dependent	JJ
cord-018804-wj35q88f	51	44	RNA	RNA	NNP
cord-018804-wj35q88f	51	45	synthesis	synthesis	NN
cord-018804-wj35q88f	51	46	.	.	.
cord-018804-wj35q88f	52	1	The	the	DT
cord-018804-wj35q88f	52	2	template	template	NN
cord-018804-wj35q88f	52	3	RNA	RNA	NNP
cord-018804-wj35q88f	52	4	can	can	MD
cord-018804-wj35q88f	52	5	be	be	VB
cord-018804-wj35q88f	52	6	of	of	IN
cord-018804-wj35q88f	52	7	positive	positive	JJ
cord-018804-wj35q88f	52	8	polarity	polarity	NN
cord-018804-wj35q88f	52	9	(	(	-LRB-
cord-018804-wj35q88f	52	10	it	-PRON-	PRP
cord-018804-wj35q88f	52	11	can	can	MD
cord-018804-wj35q88f	52	12	work	work	VB
cord-018804-wj35q88f	52	13	as	as	IN
cord-018804-wj35q88f	52	14	mRNA	mRNA	NNP
cord-018804-wj35q88f	52	15	)	)	-RRB-
cord-018804-wj35q88f	52	16	or	or	CC
cord-018804-wj35q88f	52	17	negative	negative	JJ
cord-018804-wj35q88f	52	18	polarity	polarity	NN
cord-018804-wj35q88f	52	19	(	(	-LRB-
cord-018804-wj35q88f	52	20	it	-PRON-	PRP
cord-018804-wj35q88f	52	21	is	be	VBZ
cord-018804-wj35q88f	52	22	the	the	DT
cord-018804-wj35q88f	52	23	complementary	complementary	JJ
cord-018804-wj35q88f	52	24	strand	strand	NN
cord-018804-wj35q88f	52	25	that	that	WDT
cord-018804-wj35q88f	52	26	is	be	VBZ
cord-018804-wj35q88f	52	27	translated	translate	VBN
cord-018804-wj35q88f	52	28	into	into	IN
cord-018804-wj35q88f	52	29	proteins	protein	NNS
cord-018804-wj35q88f	52	30	)	)	-RRB-
cord-018804-wj35q88f	52	31	.	.	.
cord-018804-wj35q88f	53	1	Viruses	virus	NNS
cord-018804-wj35q88f	53	2	with	with	IN
cord-018804-wj35q88f	53	3	positive	positive	JJ
cord-018804-wj35q88f	53	4	polarity	polarity	NN
cord-018804-wj35q88f	53	5	genomes	genome	NNS
cord-018804-wj35q88f	53	6	deliver	deliver	VBP
cord-018804-wj35q88f	53	7	the	the	DT
cord-018804-wj35q88f	53	8	nucleic	nucleic	JJ
cord-018804-wj35q88f	53	9	acid	acid	NN
cord-018804-wj35q88f	53	10	directly	directly	RB
cord-018804-wj35q88f	53	11	to	to	IN
cord-018804-wj35q88f	53	12	the	the	DT
cord-018804-wj35q88f	53	13	cellular	cellular	JJ
cord-018804-wj35q88f	53	14	ribosomes	ribosome	NNS
cord-018804-wj35q88f	53	15	and	and	CC
cord-018804-wj35q88f	53	16	begin	begin	VBP
cord-018804-wj35q88f	53	17	infections	infection	NNS
cord-018804-wj35q88f	53	18	with	with	IN
cord-018804-wj35q88f	53	19	translation	translation	NN
cord-018804-wj35q88f	53	20	.	.	.
cord-018804-wj35q88f	54	1	In	in	IN
cord-018804-wj35q88f	54	2	contrast	contrast	NN
cord-018804-wj35q88f	54	3	,	,	,
cord-018804-wj35q88f	54	4	viruses	virus	NNS
cord-018804-wj35q88f	54	5	with	with	IN
cord-018804-wj35q88f	54	6	negative	negative	JJ
cord-018804-wj35q88f	54	7	polarity	polarity	NN
cord-018804-wj35q88f	54	8	genomes	genome	NNS
cord-018804-wj35q88f	54	9	begin	begin	VBP
cord-018804-wj35q88f	54	10	infections	infection	NNS
cord-018804-wj35q88f	54	11	with	with	IN
cord-018804-wj35q88f	54	12	transcription	transcription	NN
cord-018804-wj35q88f	54	13	to	to	TO
cord-018804-wj35q88f	54	14	obtain	obtain	VB
cord-018804-wj35q88f	54	15	mRNA	mrna	NN
cord-018804-wj35q88f	54	16	molecules	molecule	NNS
cord-018804-wj35q88f	54	17	that	that	WDT
cord-018804-wj35q88f	54	18	can	can	MD
cord-018804-wj35q88f	54	19	be	be	VB
cord-018804-wj35q88f	54	20	translated	translate	VBN
cord-018804-wj35q88f	54	21	.	.	.
cord-018804-wj35q88f	55	1	Retroviruses	retrovirus	NNS
cord-018804-wj35q88f	55	2	,	,	,
cord-018804-wj35q88f	55	3	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	55	4	(	(	-LRB-
cord-018804-wj35q88f	55	5	human	human	JJ
cord-018804-wj35q88f	55	6	immunodeficiency	immunodeficiency	NN
cord-018804-wj35q88f	55	7	virus	virus	NN
cord-018804-wj35q88f	55	8	type	type	NN
cord-018804-wj35q88f	55	9	1	1	CD
cord-018804-wj35q88f	55	10	)	)	-RRB-
cord-018804-wj35q88f	55	11	being	be	VBG
cord-018804-wj35q88f	55	12	the	the	DT
cord-018804-wj35q88f	55	13	best	well	RBS
cord-018804-wj35q88f	55	14	known	know	VBN
cord-018804-wj35q88f	55	15	example	example	NN
cord-018804-wj35q88f	55	16	,	,	,
cord-018804-wj35q88f	55	17	replicate	replicate	VBP
cord-018804-wj35q88f	55	18	their	-PRON-	PRP$
cord-018804-wj35q88f	55	19	genomes	genome	NNS
cord-018804-wj35q88f	55	20	through	through	IN
cord-018804-wj35q88f	55	21	a	a	DT
cord-018804-wj35q88f	55	22	different	different	JJ
cord-018804-wj35q88f	55	23	mechanism	mechanism	NN
cord-018804-wj35q88f	55	24	with	with	IN
cord-018804-wj35q88f	55	25	an	an	DT
cord-018804-wj35q88f	55	26	intermediary	intermediary	JJ
cord-018804-wj35q88f	55	27	step	step	NN
cord-018804-wj35q88f	55	28	that	that	WDT
cord-018804-wj35q88f	55	29	consists	consist	VBZ
cord-018804-wj35q88f	55	30	in	in	IN
cord-018804-wj35q88f	55	31	the	the	DT
cord-018804-wj35q88f	55	32	copy	copy	NN
cord-018804-wj35q88f	55	33	of	of	IN
cord-018804-wj35q88f	55	34	the	the	DT
cord-018804-wj35q88f	55	35	genomic	genomic	JJ
cord-018804-wj35q88f	55	36	RNA	RNA	NNP
cord-018804-wj35q88f	55	37	to	to	IN
cord-018804-wj35q88f	55	38	DNA	DNA	NNP
cord-018804-wj35q88f	55	39	.	.	.
cord-018804-wj35q88f	56	1	This	this	DT
cord-018804-wj35q88f	56	2	process	process	NN
cord-018804-wj35q88f	56	3	is	be	VBZ
cord-018804-wj35q88f	56	4	catalyzed	catalyze	VBN
cord-018804-wj35q88f	56	5	by	by	IN
cord-018804-wj35q88f	56	6	the	the	DT
cord-018804-wj35q88f	56	7	enzyme	enzyme	NN
cord-018804-wj35q88f	56	8	reverse	reverse	NN
cord-018804-wj35q88f	56	9	transcriptase	transcriptase	NN
cord-018804-wj35q88f	56	10	,	,	,
cord-018804-wj35q88f	56	11	an	an	DT
cord-018804-wj35q88f	56	12	RNA	rna	NN
cord-018804-wj35q88f	56	13	-	-	HYPH
cord-018804-wj35q88f	56	14	dependent	dependent	JJ
cord-018804-wj35q88f	56	15	DNA	dna	NN
cord-018804-wj35q88f	56	16	polymerase	polymerase	NN
cord-018804-wj35q88f	56	17	carried	carry	VBN
cord-018804-wj35q88f	56	18	by	by	IN
cord-018804-wj35q88f	56	19	the	the	DT
cord-018804-wj35q88f	56	20	viral	viral	JJ
cord-018804-wj35q88f	56	21	particle	particle	NN
cord-018804-wj35q88f	56	22	.	.	.
cord-018804-wj35q88f	57	1	The	the	DT
cord-018804-wj35q88f	57	2	DNA	dna	NN
cord-018804-wj35q88f	57	3	obtained	obtain	VBN
cord-018804-wj35q88f	57	4	in	in	IN
cord-018804-wj35q88f	57	5	this	this	DT
cord-018804-wj35q88f	57	6	way	way	NN
cord-018804-wj35q88f	57	7	is	be	VBZ
cord-018804-wj35q88f	57	8	integrated	integrate	VBN
cord-018804-wj35q88f	57	9	in	in	IN
cord-018804-wj35q88f	57	10	the	the	DT
cord-018804-wj35q88f	57	11	host	host	NN
cord-018804-wj35q88f	57	12	chromosome	chromosome	NN
cord-018804-wj35q88f	57	13	,	,	,
cord-018804-wj35q88f	57	14	being	be	VBG
cord-018804-wj35q88f	57	15	transcribed	transcribe	VBN
cord-018804-wj35q88f	57	16	by	by	IN
cord-018804-wj35q88f	57	17	the	the	DT
cord-018804-wj35q88f	57	18	cellular	cellular	JJ
cord-018804-wj35q88f	57	19	enzyme	enzyme	NN
cord-018804-wj35q88f	57	20	RNA	rna	NN
cord-018804-wj35q88f	57	21	polymerase	polymerase	NN
cord-018804-wj35q88f	57	22	II	II	NNP
cord-018804-wj35q88f	57	23	to	to	TO
cord-018804-wj35q88f	57	24	produce	produce	VB
cord-018804-wj35q88f	57	25	transcripts	transcript	NNS
cord-018804-wj35q88f	57	26	that	that	WDT
cord-018804-wj35q88f	57	27	can	can	MD
cord-018804-wj35q88f	57	28	function	function	VB
cord-018804-wj35q88f	57	29	either	either	CC
cord-018804-wj35q88f	57	30	as	as	IN
cord-018804-wj35q88f	57	31	precursors	precursor	NNS
cord-018804-wj35q88f	57	32	of	of	IN
cord-018804-wj35q88f	57	33	mRNAs	mrnas	CD
cord-018804-wj35q88f	57	34	or	or	CC
cord-018804-wj35q88f	57	35	as	as	IN
cord-018804-wj35q88f	57	36	genomic	genomic	JJ
cord-018804-wj35q88f	57	37	RNAs	rna	NNS
cord-018804-wj35q88f	57	38	that	that	WDT
cord-018804-wj35q88f	57	39	can	can	MD
cord-018804-wj35q88f	57	40	be	be	VB
cord-018804-wj35q88f	57	41	assembled	assemble	VBN
cord-018804-wj35q88f	57	42	into	into	IN
cord-018804-wj35q88f	57	43	progeny	progeny	NN
cord-018804-wj35q88f	57	44	viruses	virus	NNS
cord-018804-wj35q88f	57	45	.	.	.
cord-018804-wj35q88f	58	1	The	the	DT
cord-018804-wj35q88f	58	2	lack	lack	NN
cord-018804-wj35q88f	58	3	of	of	IN
cord-018804-wj35q88f	58	4	corrector	corrector	NN
cord-018804-wj35q88f	58	5	activities	activity	NNS
cord-018804-wj35q88f	58	6	of	of	IN
cord-018804-wj35q88f	58	7	both	both	DT
cord-018804-wj35q88f	58	8	classes	class	NNS
cord-018804-wj35q88f	58	9	of	of	IN
cord-018804-wj35q88f	58	10	enzymes	enzyme	NNS
cord-018804-wj35q88f	58	11	RNA	RNA	NNP
cord-018804-wj35q88f	58	12	replicases	replicase	NNS
cord-018804-wj35q88f	58	13	and	and	CC
cord-018804-wj35q88f	58	14	reverse	reverse	VB
cord-018804-wj35q88f	58	15	transcriptases	transcriptase	NNS
cord-018804-wj35q88f	58	16	results	result	NNS
cord-018804-wj35q88f	58	17	in	in	IN
cord-018804-wj35q88f	58	18	high	high	JJ
cord-018804-wj35q88f	58	19	mutation	mutation	NN
cord-018804-wj35q88f	58	20	rates	rate	NNS
cord-018804-wj35q88f	58	21	,	,	,
cord-018804-wj35q88f	58	22	which	which	WDT
cord-018804-wj35q88f	58	23	have	have	VBP
cord-018804-wj35q88f	58	24	been	be	VBN
cord-018804-wj35q88f	58	25	estimated	estimate	VBN
cord-018804-wj35q88f	58	26	in	in	IN
cord-018804-wj35q88f	58	27	10	10	CD
cord-018804-wj35q88f	58	28	−4	−4	CD
cord-018804-wj35q88f	58	29	to	to	IN
cord-018804-wj35q88f	58	30	10	10	CD
cord-018804-wj35q88f	58	31	−5	−5	NNS
cord-018804-wj35q88f	59	1	misincorporations	misincorporation	NNS
cord-018804-wj35q88f	59	2	per	per	IN
cord-018804-wj35q88f	59	3	nucleotide	nucleotide	NN
cord-018804-wj35q88f	59	4	copied	copy	VBN
cord-018804-wj35q88f	59	5	.	.	.
cord-018804-wj35q88f	60	1	For	for	IN
cord-018804-wj35q88f	60	2	a	a	DT
cord-018804-wj35q88f	60	3	virus	virus	NN
cord-018804-wj35q88f	60	4	with	with	IN
cord-018804-wj35q88f	60	5	a	a	DT
cord-018804-wj35q88f	60	6	genome	genome	NN
cord-018804-wj35q88f	60	7	length	length	NN
cord-018804-wj35q88f	60	8	of	of	IN
cord-018804-wj35q88f	60	9	10,000	10,000	CD
cord-018804-wj35q88f	60	10	nucleotides	nucleotide	NNS
cord-018804-wj35q88f	60	11	,	,	,
cord-018804-wj35q88f	60	12	this	this	DT
cord-018804-wj35q88f	60	13	amounts	amount	VBZ
cord-018804-wj35q88f	60	14	to	to	IN
cord-018804-wj35q88f	60	15	the	the	DT
cord-018804-wj35q88f	60	16	incorporation	incorporation	NN
cord-018804-wj35q88f	60	17	of	of	IN
cord-018804-wj35q88f	60	18	one	one	CD
cord-018804-wj35q88f	60	19	incorrect	incorrect	JJ
cord-018804-wj35q88f	60	20	nucleotide	nucleotide	NN
cord-018804-wj35q88f	60	21	per	per	IN
cord-018804-wj35q88f	60	22	genome	genome	NN
cord-018804-wj35q88f	60	23	copied	copy	VBN
cord-018804-wj35q88f	60	24	on	on	IN
cord-018804-wj35q88f	60	25	the	the	DT
cord-018804-wj35q88f	60	26	average	average	JJ
cord-018804-wj35q88f	60	27	[	[	-LRB-
cord-018804-wj35q88f	60	28	6	6	CD
cord-018804-wj35q88f	60	29	,	,	,
cord-018804-wj35q88f	60	30	11	11	CD
cord-018804-wj35q88f	60	31	]	]	-RRB-
cord-018804-wj35q88f	60	32	.	.	.
cord-018804-wj35q88f	61	1	Thus	thus	RB
cord-018804-wj35q88f	61	2	,	,	,
cord-018804-wj35q88f	61	3	each	each	DT
cord-018804-wj35q88f	61	4	new	new	JJ
cord-018804-wj35q88f	61	5	viral	viral	JJ
cord-018804-wj35q88f	61	6	genome	genome	NN
cord-018804-wj35q88f	61	7	differs	differ	VBZ
cord-018804-wj35q88f	61	8	from	from	IN
cord-018804-wj35q88f	61	9	its	-PRON-	PRP$
cord-018804-wj35q88f	61	10	parent	parent	NN
cord-018804-wj35q88f	61	11	at	at	IN
cord-018804-wj35q88f	61	12	one	one	CD
cord-018804-wj35q88f	61	13	or	or	CC
cord-018804-wj35q88f	61	14	two	two	CD
cord-018804-wj35q88f	61	15	nucleotide	nucleotide	JJ
cord-018804-wj35q88f	61	16	positions	position	NNS
cord-018804-wj35q88f	61	17	.	.	.
cord-018804-wj35q88f	62	1	The	the	DT
cord-018804-wj35q88f	62	2	relative	relative	JJ
cord-018804-wj35q88f	62	3	proportion	proportion	NN
cord-018804-wj35q88f	62	4	of	of	IN
cord-018804-wj35q88f	62	5	a	a	DT
cord-018804-wj35q88f	62	6	specific	specific	JJ
cord-018804-wj35q88f	62	7	mutant	mutant	NN
cord-018804-wj35q88f	62	8	in	in	IN
cord-018804-wj35q88f	62	9	the	the	DT
cord-018804-wj35q88f	62	10	viral	viral	JJ
cord-018804-wj35q88f	62	11	population	population	NN
cord-018804-wj35q88f	62	12	depends	depend	VBZ
cord-018804-wj35q88f	62	13	on	on	IN
cord-018804-wj35q88f	62	14	the	the	DT
cord-018804-wj35q88f	62	15	rate	rate	NN
cord-018804-wj35q88f	62	16	at	at	IN
cord-018804-wj35q88f	62	17	which	which	WDT
cord-018804-wj35q88f	62	18	the	the	DT
cord-018804-wj35q88f	62	19	mutant	mutant	NN
cord-018804-wj35q88f	62	20	is	be	VBZ
cord-018804-wj35q88f	62	21	generated	generate	VBN
cord-018804-wj35q88f	62	22	and	and	CC
cord-018804-wj35q88f	62	23	on	on	IN
cord-018804-wj35q88f	62	24	its	-PRON-	PRP$
cord-018804-wj35q88f	62	25	fitness	fitness	NN
cord-018804-wj35q88f	62	26	,	,	,
cord-018804-wj35q88f	62	27	which	which	WDT
cord-018804-wj35q88f	62	28	is	be	VBZ
cord-018804-wj35q88f	62	29	defined	define	VBN
cord-018804-wj35q88f	62	30	as	as	IN
cord-018804-wj35q88f	62	31	the	the	DT
cord-018804-wj35q88f	62	32	ability	ability	NN
cord-018804-wj35q88f	62	33	to	to	TO
cord-018804-wj35q88f	62	34	give	give	VB
cord-018804-wj35q88f	62	35	rise	rise	NN
cord-018804-wj35q88f	62	36	to	to	IN
cord-018804-wj35q88f	62	37	a	a	DT
cord-018804-wj35q88f	62	38	progeny	progeny	NN
cord-018804-wj35q88f	62	39	in	in	IN
cord-018804-wj35q88f	62	40	competition	competition	NN
cord-018804-wj35q88f	62	41	with	with	IN
cord-018804-wj35q88f	62	42	the	the	DT
cord-018804-wj35q88f	62	43	rest	rest	NN
cord-018804-wj35q88f	62	44	of	of	IN
cord-018804-wj35q88f	62	45	viruses	virus	NNS
cord-018804-wj35q88f	62	46	replicating	replicate	VBG
cord-018804-wj35q88f	62	47	under	under	IN
cord-018804-wj35q88f	62	48	certain	certain	JJ
cord-018804-wj35q88f	62	49	environmental	environmental	JJ
cord-018804-wj35q88f	62	50	conditions	condition	NNS
cord-018804-wj35q88f	62	51	[	[	-LRB-
cord-018804-wj35q88f	62	52	7	7	CD
cord-018804-wj35q88f	62	53	]	]	-RRB-
cord-018804-wj35q88f	62	54	.	.	.
cord-018804-wj35q88f	63	1	The	the	DT
cord-018804-wj35q88f	63	2	number	number	NN
cord-018804-wj35q88f	63	3	of	of	IN
cord-018804-wj35q88f	63	4	mutations	mutation	NNS
cord-018804-wj35q88f	63	5	that	that	WDT
cord-018804-wj35q88f	63	6	occur	occur	VBP
cord-018804-wj35q88f	63	7	per	per	IN
cord-018804-wj35q88f	63	8	time	time	NN
cord-018804-wj35q88f	63	9	unit	unit	NN
cord-018804-wj35q88f	63	10	is	be	VBZ
cord-018804-wj35q88f	63	11	also	also	RB
cord-018804-wj35q88f	63	12	influenced	influence	VBN
cord-018804-wj35q88f	63	13	by	by	IN
cord-018804-wj35q88f	63	14	the	the	DT
cord-018804-wj35q88f	63	15	number	number	NN
cord-018804-wj35q88f	63	16	of	of	IN
cord-018804-wj35q88f	63	17	replication	replication	NN
cord-018804-wj35q88f	63	18	rounds	round	NNS
cord-018804-wj35q88f	63	19	during	during	IN
cord-018804-wj35q88f	63	20	that	that	DT
cord-018804-wj35q88f	63	21	period	period	NN
cord-018804-wj35q88f	63	22	,	,	,
cord-018804-wj35q88f	63	23	this	this	DT
cord-018804-wj35q88f	63	24	is	be	VBZ
cord-018804-wj35q88f	63	25	,	,	,
cord-018804-wj35q88f	63	26	the	the	DT
cord-018804-wj35q88f	63	27	generation	generation	NN
cord-018804-wj35q88f	63	28	time	time	NN
cord-018804-wj35q88f	63	29	.	.	.
cord-018804-wj35q88f	64	1	For	for	IN
cord-018804-wj35q88f	64	2	viruses	virus	NNS
cord-018804-wj35q88f	64	3	with	with	IN
cord-018804-wj35q88f	64	4	similar	similar	JJ
cord-018804-wj35q88f	64	5	error	error	NN
cord-018804-wj35q88f	64	6	rate	rate	NN
cord-018804-wj35q88f	64	7	polymerases	polymerase	NNS
cord-018804-wj35q88f	64	8	,	,	,
cord-018804-wj35q88f	64	9	the	the	DT
cord-018804-wj35q88f	64	10	shorter	short	JJR
cord-018804-wj35q88f	64	11	the	the	DT
cord-018804-wj35q88f	64	12	generation	generation	NN
cord-018804-wj35q88f	64	13	time	time	NN
cord-018804-wj35q88f	64	14	,	,	,
cord-018804-wj35q88f	64	15	the	the	DT
cord-018804-wj35q88f	64	16	larger	large	JJR
cord-018804-wj35q88f	64	17	the	the	DT
cord-018804-wj35q88f	64	18	number	number	NN
cord-018804-wj35q88f	64	19	of	of	IN
cord-018804-wj35q88f	64	20	mutants	mutant	NNS
cord-018804-wj35q88f	64	21	that	that	WDT
cord-018804-wj35q88f	64	22	is	be	VBZ
cord-018804-wj35q88f	64	23	produced	produce	VBN
cord-018804-wj35q88f	64	24	in	in	IN
cord-018804-wj35q88f	64	25	the	the	DT
cord-018804-wj35q88f	64	26	same	same	JJ
cord-018804-wj35q88f	64	27	time	time	NN
cord-018804-wj35q88f	64	28	interval	interval	NN
cord-018804-wj35q88f	64	29	.	.	.
cord-018804-wj35q88f	65	1	Recombination	recombination	NN
cord-018804-wj35q88f	65	2	takes	take	VBZ
cord-018804-wj35q88f	65	3	place	place	NN
cord-018804-wj35q88f	65	4	when	when	WRB
cord-018804-wj35q88f	65	5	a	a	DT
cord-018804-wj35q88f	65	6	new	new	JJ
cord-018804-wj35q88f	65	7	genome	genome	NN
cord-018804-wj35q88f	65	8	is	be	VBZ
cord-018804-wj35q88f	65	9	built	build	VBN
cord-018804-wj35q88f	65	10	from	from	IN
cord-018804-wj35q88f	65	11	fragments	fragment	NNS
cord-018804-wj35q88f	65	12	belonging	belong	VBG
cord-018804-wj35q88f	65	13	to	to	IN
cord-018804-wj35q88f	65	14	different	different	JJ
cord-018804-wj35q88f	65	15	parental	parental	JJ
cord-018804-wj35q88f	65	16	molecules	molecule	NNS
cord-018804-wj35q88f	65	17	.	.	.
cord-018804-wj35q88f	66	1	In	in	IN
cord-018804-wj35q88f	66	2	RNA	RNA	NNP
cord-018804-wj35q88f	66	3	viruses	virus	NNS
cord-018804-wj35q88f	66	4	,	,	,
cord-018804-wj35q88f	66	5	this	this	DT
cord-018804-wj35q88f	66	6	process	process	NN
cord-018804-wj35q88f	66	7	usually	usually	RB
cord-018804-wj35q88f	66	8	occurs	occur	VBZ
cord-018804-wj35q88f	66	9	by	by	IN
cord-018804-wj35q88f	66	10	template	template	NN
cord-018804-wj35q88f	66	11	switching	switch	VBG
cord-018804-wj35q88f	66	12	during	during	IN
cord-018804-wj35q88f	66	13	RNA	RNA	NNP
cord-018804-wj35q88f	66	14	or	or	CC
cord-018804-wj35q88f	66	15	cDNA	cdna	NN
cord-018804-wj35q88f	66	16	synthesis	synthesis	NN
cord-018804-wj35q88f	66	17	.	.	.
cord-018804-wj35q88f	67	1	Most	Most	JJS
cord-018804-wj35q88f	67	2	studies	study	NNS
cord-018804-wj35q88f	67	3	suggest	suggest	VBP
cord-018804-wj35q88f	67	4	that	that	IN
cord-018804-wj35q88f	67	5	recombination	recombination	NN
cord-018804-wj35q88f	67	6	rates	rate	NNS
cord-018804-wj35q88f	67	7	in	in	IN
cord-018804-wj35q88f	67	8	RNA	RNA	NNP
cord-018804-wj35q88f	67	9	viruses	virus	NNS
cord-018804-wj35q88f	67	10	are	be	VBP
cord-018804-wj35q88f	67	11	lower	low	JJR
cord-018804-wj35q88f	67	12	than	than	IN
cord-018804-wj35q88f	67	13	in	in	IN
cord-018804-wj35q88f	67	14	other	other	JJ
cord-018804-wj35q88f	67	15	organisms	organism	NNS
cord-018804-wj35q88f	67	16	[	[	-LRB-
cord-018804-wj35q88f	67	17	12	12	CD
cord-018804-wj35q88f	67	18	]	]	-RRB-
cord-018804-wj35q88f	67	19	,	,	,
cord-018804-wj35q88f	67	20	although	although	IN
cord-018804-wj35q88f	67	21	there	there	EX
cord-018804-wj35q88f	67	22	are	be	VBP
cord-018804-wj35q88f	67	23	some	some	DT
cord-018804-wj35q88f	67	24	notable	notable	JJ
cord-018804-wj35q88f	67	25	exceptions	exception	NNS
cord-018804-wj35q88f	67	26	,	,	,
cord-018804-wj35q88f	67	27	such	such	JJ
cord-018804-wj35q88f	67	28	as	as	IN
cord-018804-wj35q88f	67	29	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	67	30	in	in	IN
cord-018804-wj35q88f	67	31	which	which	WDT
cord-018804-wj35q88f	67	32	the	the	DT
cord-018804-wj35q88f	67	33	recombination	recombination	NN
cord-018804-wj35q88f	67	34	rate	rate	NN
cord-018804-wj35q88f	67	35	seems	seem	VBZ
cord-018804-wj35q88f	67	36	to	to	TO
cord-018804-wj35q88f	67	37	be	be	VB
cord-018804-wj35q88f	67	38	higher	high	JJR
cord-018804-wj35q88f	67	39	than	than	IN
cord-018804-wj35q88f	67	40	the	the	DT
cord-018804-wj35q88f	67	41	mutation	mutation	NN
cord-018804-wj35q88f	67	42	rate	rate	NN
cord-018804-wj35q88f	67	43	[	[	-LRB-
cord-018804-wj35q88f	67	44	13	13	CD
cord-018804-wj35q88f	67	45	]	]	-RRB-
cord-018804-wj35q88f	67	46	.	.	.
cord-018804-wj35q88f	68	1	Recombination	recombination	NN
cord-018804-wj35q88f	68	2	can	can	MD
cord-018804-wj35q88f	68	3	be	be	VB
cord-018804-wj35q88f	68	4	a	a	DT
cord-018804-wj35q88f	68	5	powerful	powerful	JJ
cord-018804-wj35q88f	68	6	mechanism	mechanism	NN
cord-018804-wj35q88f	68	7	to	to	TO
cord-018804-wj35q88f	68	8	create	create	VB
cord-018804-wj35q88f	68	9	advantageous	advantageous	JJ
cord-018804-wj35q88f	68	10	genomes	genome	NNS
cord-018804-wj35q88f	68	11	and	and	CC
cord-018804-wj35q88f	68	12	to	to	TO
cord-018804-wj35q88f	68	13	purge	purge	VB
cord-018804-wj35q88f	68	14	deleterious	deleterious	JJ
cord-018804-wj35q88f	68	15	mutations	mutation	NNS
cord-018804-wj35q88f	68	16	in	in	IN
cord-018804-wj35q88f	68	17	a	a	DT
cord-018804-wj35q88f	68	18	very	very	RB
cord-018804-wj35q88f	68	19	short	short	JJ
cord-018804-wj35q88f	68	20	time	time	NN
cord-018804-wj35q88f	68	21	.	.	.
cord-018804-wj35q88f	69	1	However	however	RB
cord-018804-wj35q88f	69	2	,	,	,
cord-018804-wj35q88f	69	3	the	the	DT
cord-018804-wj35q88f	69	4	actual	actual	JJ
cord-018804-wj35q88f	69	5	effects	effect	NNS
cord-018804-wj35q88f	69	6	of	of	IN
cord-018804-wj35q88f	69	7	recombination	recombination	NN
cord-018804-wj35q88f	69	8	in	in	IN
cord-018804-wj35q88f	69	9	RNA	RNA	NNP
cord-018804-wj35q88f	69	10	viruses	virus	NNS
cord-018804-wj35q88f	69	11	have	have	VBP
cord-018804-wj35q88f	69	12	not	not	RB
cord-018804-wj35q88f	69	13	been	be	VBN
cord-018804-wj35q88f	69	14	studied	study	VBN
cord-018804-wj35q88f	69	15	in	in	IN
cord-018804-wj35q88f	69	16	detail	detail	NN
cord-018804-wj35q88f	69	17	,	,	,
cord-018804-wj35q88f	69	18	and	and	CC
cord-018804-wj35q88f	69	19	it	-PRON-	PRP
cord-018804-wj35q88f	69	20	is	be	VBZ
cord-018804-wj35q88f	69	21	not	not	RB
cord-018804-wj35q88f	69	22	clear	clear	JJ
cord-018804-wj35q88f	69	23	whether	whether	IN
cord-018804-wj35q88f	69	24	it	-PRON-	PRP
cord-018804-wj35q88f	69	25	is	be	VBZ
cord-018804-wj35q88f	69	26	beneficial	beneficial	JJ
cord-018804-wj35q88f	69	27	or	or	CC
cord-018804-wj35q88f	69	28	it	-PRON-	PRP
cord-018804-wj35q88f	69	29	has	have	VBZ
cord-018804-wj35q88f	69	30	a	a	DT
cord-018804-wj35q88f	69	31	negative	negative	JJ
cord-018804-wj35q88f	69	32	effect	effect	NN
cord-018804-wj35q88f	69	33	on	on	IN
cord-018804-wj35q88f	69	34	fitness	fitness	NN
cord-018804-wj35q88f	69	35	[	[	-LRB-
cord-018804-wj35q88f	69	36	14	14	CD
cord-018804-wj35q88f	69	37	]	]	-RRB-
cord-018804-wj35q88f	69	38	.	.	.
cord-018804-wj35q88f	70	1	Genome	genome	NN
cord-018804-wj35q88f	70	2	segment	segment	NN
cord-018804-wj35q88f	70	3	reassortment	reassortment	NN
cord-018804-wj35q88f	70	4	occurs	occur	VBZ
cord-018804-wj35q88f	70	5	in	in	IN
cord-018804-wj35q88f	70	6	viruses	virus	NNS
cord-018804-wj35q88f	70	7	with	with	IN
cord-018804-wj35q88f	70	8	segmented	segmented	JJ
cord-018804-wj35q88f	70	9	genomes	genome	NNS
cord-018804-wj35q88f	70	10	and	and	CC
cord-018804-wj35q88f	70	11	consists	consist	VBZ
cord-018804-wj35q88f	70	12	in	in	IN
cord-018804-wj35q88f	70	13	the	the	DT
cord-018804-wj35q88f	70	14	encapsidation	encapsidation	NN
cord-018804-wj35q88f	70	15	in	in	IN
cord-018804-wj35q88f	70	16	the	the	DT
cord-018804-wj35q88f	70	17	same	same	JJ
cord-018804-wj35q88f	70	18	viral	viral	JJ
cord-018804-wj35q88f	70	19	particle	particle	NN
cord-018804-wj35q88f	70	20	of	of	IN
cord-018804-wj35q88f	70	21	genome	genome	NN
cord-018804-wj35q88f	70	22	segments	segment	NNS
cord-018804-wj35q88f	70	23	proceeding	proceed	VBG
cord-018804-wj35q88f	70	24	from	from	IN
cord-018804-wj35q88f	70	25	different	different	JJ
cord-018804-wj35q88f	70	26	parental	parental	JJ
cord-018804-wj35q88f	70	27	viruses	virus	NNS
cord-018804-wj35q88f	70	28	.	.	.
cord-018804-wj35q88f	71	1	Influenza	influenza	NN
cord-018804-wj35q88f	71	2	viruses	virus	NNS
cord-018804-wj35q88f	71	3	are	be	VBP
cord-018804-wj35q88f	71	4	the	the	DT
cord-018804-wj35q88f	71	5	typical	typical	JJ
cord-018804-wj35q88f	71	6	example	example	NN
cord-018804-wj35q88f	71	7	in	in	IN
cord-018804-wj35q88f	71	8	which	which	WDT
cord-018804-wj35q88f	71	9	this	this	DT
cord-018804-wj35q88f	71	10	process	process	NN
cord-018804-wj35q88f	71	11	has	have	VBZ
cord-018804-wj35q88f	71	12	been	be	VBN
cord-018804-wj35q88f	71	13	responsible	responsible	JJ
cord-018804-wj35q88f	71	14	for	for	IN
cord-018804-wj35q88f	71	15	antigenic	antigenic	JJ
cord-018804-wj35q88f	71	16	shifts	shift	NNS
cord-018804-wj35q88f	71	17	,	,	,
cord-018804-wj35q88f	71	18	probably	probably	RB
cord-018804-wj35q88f	71	19	resulting	result	VBG
cord-018804-wj35q88f	71	20	from	from	IN
cord-018804-wj35q88f	71	21	combinations	combination	NNS
cord-018804-wj35q88f	71	22	of	of	IN
cord-018804-wj35q88f	71	23	segments	segment	NNS
cord-018804-wj35q88f	71	24	of	of	IN
cord-018804-wj35q88f	71	25	influenza	influenza	NN
cord-018804-wj35q88f	71	26	virus	virus	NN
cord-018804-wj35q88f	71	27	of	of	IN
cord-018804-wj35q88f	71	28	different	different	JJ
cord-018804-wj35q88f	71	29	specificity	specificity	NN
cord-018804-wj35q88f	71	30	[	[	-LRB-
cord-018804-wj35q88f	71	31	15	15	CD
cord-018804-wj35q88f	71	32	]	]	-RRB-
cord-018804-wj35q88f	71	33	.	.	.
cord-018804-wj35q88f	72	1	The	the	DT
cord-018804-wj35q88f	72	2	natural	natural	JJ
cord-018804-wj35q88f	72	3	reservoir	reservoir	NN
cord-018804-wj35q88f	72	4	of	of	IN
cord-018804-wj35q88f	72	5	influenza	influenza	NN
cord-018804-wj35q88f	72	6	is	be	VBZ
cord-018804-wj35q88f	72	7	aquatic	aquatic	JJ
cord-018804-wj35q88f	72	8	birds	bird	NNS
cord-018804-wj35q88f	72	9	,	,	,
cord-018804-wj35q88f	72	10	although	although	IN
cord-018804-wj35q88f	72	11	the	the	DT
cord-018804-wj35q88f	72	12	virus	virus	NN
cord-018804-wj35q88f	72	13	can	can	MD
cord-018804-wj35q88f	72	14	also	also	RB
cord-018804-wj35q88f	72	15	infect	infect	VB
cord-018804-wj35q88f	72	16	domestic	domestic	JJ
cord-018804-wj35q88f	72	17	birds	bird	NNS
cord-018804-wj35q88f	72	18	and	and	CC
cord-018804-wj35q88f	72	19	mammals	mammal	NNS
cord-018804-wj35q88f	72	20	(	(	-LRB-
cord-018804-wj35q88f	72	21	human	human	NN
cord-018804-wj35q88f	72	22	or	or	CC
cord-018804-wj35q88f	72	23	pigs	pig	NNS
cord-018804-wj35q88f	72	24	preferably	preferably	RB
cord-018804-wj35q88f	72	25	)	)	-RRB-
cord-018804-wj35q88f	72	26	.	.	.
cord-018804-wj35q88f	73	1	When	when	WRB
cord-018804-wj35q88f	73	2	a	a	DT
cord-018804-wj35q88f	73	3	reassortant	reassortant	JJ
cord-018804-wj35q88f	73	4	influenza	influenza	NN
cord-018804-wj35q88f	73	5	virus	virus	NN
cord-018804-wj35q88f	73	6	emerges	emerge	VBZ
cord-018804-wj35q88f	73	7	,	,	,
cord-018804-wj35q88f	73	8	its	-PRON-	PRP$
cord-018804-wj35q88f	73	9	pathogenic	pathogenic	JJ
cord-018804-wj35q88f	73	10	potential	potential	NN
cord-018804-wj35q88f	73	11	can	can	MD
cord-018804-wj35q88f	73	12	dramatically	dramatically	RB
cord-018804-wj35q88f	73	13	increase	increase	VB
cord-018804-wj35q88f	73	14	,	,	,
cord-018804-wj35q88f	73	15	because	because	IN
cord-018804-wj35q88f	73	16	the	the	DT
cord-018804-wj35q88f	73	17	infected	infected	JJ
cord-018804-wj35q88f	73	18	host	host	NN
cord-018804-wj35q88f	73	19	is	be	VBZ
cord-018804-wj35q88f	73	20	not	not	RB
cord-018804-wj35q88f	73	21	able	able	JJ
cord-018804-wj35q88f	73	22	to	to	TO
cord-018804-wj35q88f	73	23	recognize	recognize	VB
cord-018804-wj35q88f	73	24	the	the	DT
cord-018804-wj35q88f	73	25	antigenic	antigenic	JJ
cord-018804-wj35q88f	73	26	determinants	determinant	NNS
cord-018804-wj35q88f	73	27	of	of	IN
cord-018804-wj35q88f	73	28	the	the	DT
cord-018804-wj35q88f	73	29	new	new	JJ
cord-018804-wj35q88f	73	30	virus	virus	NN
cord-018804-wj35q88f	73	31	generated	generate	VBN
cord-018804-wj35q88f	73	32	.	.	.
cord-018804-wj35q88f	74	1	These	these	DT
cord-018804-wj35q88f	74	2	reassortant	reassortant	JJ
cord-018804-wj35q88f	74	3	strains	strain	NNS
cord-018804-wj35q88f	74	4	have	have	VBP
cord-018804-wj35q88f	74	5	been	be	VBN
cord-018804-wj35q88f	74	6	responsible	responsible	JJ
cord-018804-wj35q88f	74	7	for	for	IN
cord-018804-wj35q88f	74	8	a	a	DT
cord-018804-wj35q88f	74	9	number	number	NN
cord-018804-wj35q88f	74	10	of	of	IN
cord-018804-wj35q88f	74	11	pandemics	pandemic	NNS
cord-018804-wj35q88f	74	12	through	through	IN
cord-018804-wj35q88f	74	13	history	history	NN
cord-018804-wj35q88f	74	14	and	and	CC
cord-018804-wj35q88f	74	15	most	most	JJS
cord-018804-wj35q88f	74	16	studies	study	NNS
cord-018804-wj35q88f	74	17	suggest	suggest	VBP
cord-018804-wj35q88f	74	18	that	that	IN
cord-018804-wj35q88f	74	19	a	a	DT
cord-018804-wj35q88f	74	20	new	new	JJ
cord-018804-wj35q88f	74	21	influenza	influenza	NN
cord-018804-wj35q88f	74	22	pandemic	pandemic	NN
cord-018804-wj35q88f	74	23	is	be	VBZ
cord-018804-wj35q88f	74	24	unavoidable	unavoidable	JJ
cord-018804-wj35q88f	74	25	[	[	-LRB-
cord-018804-wj35q88f	74	26	16	16	CD
cord-018804-wj35q88f	74	27	]	]	-RRB-
cord-018804-wj35q88f	74	28	.	.	.
cord-018804-wj35q88f	75	1	The	the	DT
cord-018804-wj35q88f	75	2	structure	structure	NN
cord-018804-wj35q88f	75	3	of	of	IN
cord-018804-wj35q88f	75	4	viral	viral	JJ
cord-018804-wj35q88f	75	5	populations	population	NNS
cord-018804-wj35q88f	75	6	results	result	VBZ
cord-018804-wj35q88f	75	7	from	from	IN
cord-018804-wj35q88f	75	8	the	the	DT
cord-018804-wj35q88f	75	9	concerted	concerted	JJ
cord-018804-wj35q88f	75	10	action	action	NN
cord-018804-wj35q88f	75	11	of	of	IN
cord-018804-wj35q88f	75	12	the	the	DT
cord-018804-wj35q88f	75	13	processes	process	NNS
cord-018804-wj35q88f	75	14	of	of	IN
cord-018804-wj35q88f	75	15	mutation	mutation	NN
cord-018804-wj35q88f	75	16	and	and	CC
cord-018804-wj35q88f	75	17	selection	selection	NN
cord-018804-wj35q88f	75	18	acting	act	VBG
cord-018804-wj35q88f	75	19	in	in	IN
cord-018804-wj35q88f	75	20	very	very	RB
cord-018804-wj35q88f	75	21	large	large	JJ
cord-018804-wj35q88f	75	22	ensembles	ensemble	NNS
cord-018804-wj35q88f	75	23	of	of	IN
cord-018804-wj35q88f	75	24	replicating	replicate	VBG
cord-018804-wj35q88f	75	25	units	unit	NNS
cord-018804-wj35q88f	75	26	.	.	.
cord-018804-wj35q88f	76	1	Population	population	NN
cord-018804-wj35q88f	76	2	size	size	NN
cord-018804-wj35q88f	76	3	fluctuations	fluctuation	NNS
cord-018804-wj35q88f	76	4	,	,	,
cord-018804-wj35q88f	76	5	which	which	WDT
cord-018804-wj35q88f	76	6	frequently	frequently	RB
cord-018804-wj35q88f	76	7	take	take	VBP
cord-018804-wj35q88f	76	8	place	place	NN
cord-018804-wj35q88f	76	9	during	during	IN
cord-018804-wj35q88f	76	10	transmission	transmission	NN
cord-018804-wj35q88f	76	11	of	of	IN
cord-018804-wj35q88f	76	12	viruses	virus	NNS
cord-018804-wj35q88f	76	13	in	in	IN
cord-018804-wj35q88f	76	14	nature	nature	NN
cord-018804-wj35q88f	76	15	,	,	,
cord-018804-wj35q88f	76	16	constitute	constitute	VB
cord-018804-wj35q88f	76	17	an	an	DT
cord-018804-wj35q88f	76	18	additional	additional	JJ
cord-018804-wj35q88f	76	19	and	and	CC
cord-018804-wj35q88f	76	20	important	important	JJ
cord-018804-wj35q88f	76	21	factor	factor	NN
cord-018804-wj35q88f	76	22	influencing	influence	VBG
cord-018804-wj35q88f	76	23	the	the	DT
cord-018804-wj35q88f	76	24	extension	extension	NN
cord-018804-wj35q88f	76	25	of	of	IN
cord-018804-wj35q88f	76	26	genetic	genetic	JJ
cord-018804-wj35q88f	76	27	diversity	diversity	NN
cord-018804-wj35q88f	76	28	from	from	IN
cord-018804-wj35q88f	76	29	which	which	WDT
cord-018804-wj35q88f	76	30	a	a	DT
cord-018804-wj35q88f	76	31	new	new	JJ
cord-018804-wj35q88f	76	32	virus	virus	NN
cord-018804-wj35q88f	76	33	population	population	NN
cord-018804-wj35q88f	76	34	will	will	MD
cord-018804-wj35q88f	76	35	be	be	VB
cord-018804-wj35q88f	76	36	generated	generate	VBN
cord-018804-wj35q88f	76	37	.	.	.
cord-018804-wj35q88f	77	1	The	the	DT
cord-018804-wj35q88f	77	2	evolution	evolution	NN
cord-018804-wj35q88f	77	3	and	and	CC
cord-018804-wj35q88f	77	4	self	self	NN
cord-018804-wj35q88f	77	5	-	-	HYPH
cord-018804-wj35q88f	77	6	organization	organization	NN
cord-018804-wj35q88f	77	7	of	of	IN
cord-018804-wj35q88f	77	8	heterogeneous	heterogeneous	JJ
cord-018804-wj35q88f	77	9	populations	population	NNS
cord-018804-wj35q88f	77	10	composed	compose	VBN
cord-018804-wj35q88f	77	11	by	by	IN
cord-018804-wj35q88f	77	12	a	a	DT
cord-018804-wj35q88f	77	13	large	large	JJ
cord-018804-wj35q88f	77	14	number	number	NN
cord-018804-wj35q88f	77	15	of	of	IN
cord-018804-wj35q88f	77	16	molecules	molecule	NNS
cord-018804-wj35q88f	77	17	subjected	subject	VBN
cord-018804-wj35q88f	77	18	to	to	IN
cord-018804-wj35q88f	77	19	error	error	NN
cord-018804-wj35q88f	77	20	-	-	HYPH
cord-018804-wj35q88f	77	21	prone	prone	JJ
cord-018804-wj35q88f	77	22	replication	replication	NN
cord-018804-wj35q88f	77	23	and	and	CC
cord-018804-wj35q88f	77	24	exposed	expose	VBN
cord-018804-wj35q88f	77	25	to	to	IN
cord-018804-wj35q88f	77	26	selection	selection	NN
cord-018804-wj35q88f	77	27	was	be	VBD
cord-018804-wj35q88f	77	28	first	first	RB
cord-018804-wj35q88f	77	29	studied	study	VBN
cord-018804-wj35q88f	77	30	theoretically	theoretically	RB
cord-018804-wj35q88f	77	31	[	[	-LRB-
cord-018804-wj35q88f	77	32	17	17	CD
cord-018804-wj35q88f	77	33	]	]	-RRB-
cord-018804-wj35q88f	77	34	.	.	.
cord-018804-wj35q88f	78	1	These	these	DT
cord-018804-wj35q88f	78	2	studies	study	NNS
cord-018804-wj35q88f	78	3	showed	show	VBD
cord-018804-wj35q88f	78	4	that	that	IN
cord-018804-wj35q88f	78	5	,	,	,
cord-018804-wj35q88f	78	6	for	for	IN
cord-018804-wj35q88f	78	7	large	large	JJ
cord-018804-wj35q88f	78	8	population	population	NN
cord-018804-wj35q88f	78	9	sizes	size	NNS
cord-018804-wj35q88f	78	10	and	and	CC
cord-018804-wj35q88f	78	11	after	after	IN
cord-018804-wj35q88f	78	12	long	long	JJ
cord-018804-wj35q88f	78	13	growth	growth	NN
cord-018804-wj35q88f	78	14	times	time	NNS
cord-018804-wj35q88f	78	15	in	in	IN
cord-018804-wj35q88f	78	16	a	a	DT
cord-018804-wj35q88f	78	17	constant	constant	JJ
cord-018804-wj35q88f	78	18	environment	environment	NN
cord-018804-wj35q88f	78	19	,	,	,
cord-018804-wj35q88f	78	20	a	a	DT
cord-018804-wj35q88f	78	21	steady	steady	JJ
cord-018804-wj35q88f	78	22	-	-	HYPH
cord-018804-wj35q88f	78	23	state	state	NN
cord-018804-wj35q88f	78	24	is	be	VBZ
cord-018804-wj35q88f	78	25	reached	reach	VBN
cord-018804-wj35q88f	78	26	where	where	WRB
cord-018804-wj35q88f	78	27	each	each	DT
cord-018804-wj35q88f	78	28	mutant	mutant	NN
cord-018804-wj35q88f	78	29	represents	represent	VBZ
cord-018804-wj35q88f	78	30	a	a	DT
cord-018804-wj35q88f	78	31	constant	constant	JJ
cord-018804-wj35q88f	78	32	fraction	fraction	NN
cord-018804-wj35q88f	78	33	of	of	IN
cord-018804-wj35q88f	78	34	the	the	DT
cord-018804-wj35q88f	78	35	total	total	JJ
cord-018804-wj35q88f	78	36	population	population	NN
cord-018804-wj35q88f	78	37	.	.	.
cord-018804-wj35q88f	79	1	This	this	DT
cord-018804-wj35q88f	79	2	equilibrium	equilibrium	NN
cord-018804-wj35q88f	79	3	population	population	NN
cord-018804-wj35q88f	79	4	was	be	VBD
cord-018804-wj35q88f	79	5	called	call	VBN
cord-018804-wj35q88f	79	6	quasi	quasi	JJ
cord-018804-wj35q88f	79	7	-	-	NN
cord-018804-wj35q88f	79	8	species	species	JJ
cord-018804-wj35q88f	79	9	[	[	-LRB-
cord-018804-wj35q88f	79	10	18	18	CD
cord-018804-wj35q88f	79	11	,	,	,
cord-018804-wj35q88f	79	12	19	19	CD
cord-018804-wj35q88f	79	13	]	]	-RRB-
cord-018804-wj35q88f	79	14	.	.	.
cord-018804-wj35q88f	80	1	The	the	DT
cord-018804-wj35q88f	80	2	most	most	RBS
cord-018804-wj35q88f	80	3	frequently	frequently	RB
cord-018804-wj35q88f	80	4	occurring	occur	VBG
cord-018804-wj35q88f	80	5	molecular	molecular	JJ
cord-018804-wj35q88f	80	6	species	specie	NNS
cord-018804-wj35q88f	80	7	,	,	,
cord-018804-wj35q88f	80	8	usually	usually	RB
cord-018804-wj35q88f	80	9	the	the	DT
cord-018804-wj35q88f	80	10	one	one	NN
cord-018804-wj35q88f	80	11	with	with	IN
cord-018804-wj35q88f	80	12	the	the	DT
cord-018804-wj35q88f	80	13	highest	high	JJS
cord-018804-wj35q88f	80	14	fitness	fitness	NN
cord-018804-wj35q88f	80	15	,	,	,
cord-018804-wj35q88f	80	16	is	be	VBZ
cord-018804-wj35q88f	80	17	called	call	VBN
cord-018804-wj35q88f	80	18	the	the	DT
cord-018804-wj35q88f	80	19	master	master	NN
cord-018804-wj35q88f	80	20	sequence	sequence	NN
cord-018804-wj35q88f	80	21	.	.	.
cord-018804-wj35q88f	81	1	This	this	DT
cord-018804-wj35q88f	81	2	sequence	sequence	NN
cord-018804-wj35q88f	81	3	is	be	VBZ
cord-018804-wj35q88f	81	4	accompanied	accompany	VBN
cord-018804-wj35q88f	81	5	by	by	IN
cord-018804-wj35q88f	81	6	a	a	DT
cord-018804-wj35q88f	81	7	mutant	mutant	JJ
cord-018804-wj35q88f	81	8	spectrum	spectrum	NN
cord-018804-wj35q88f	81	9	,	,	,
cord-018804-wj35q88f	81	10	composed	compose	VBN
cord-018804-wj35q88f	81	11	by	by	IN
cord-018804-wj35q88f	81	12	an	an	DT
cord-018804-wj35q88f	81	13	ensemble	ensemble	NN
cord-018804-wj35q88f	81	14	of	of	IN
cord-018804-wj35q88f	81	15	variants	variant	NNS
cord-018804-wj35q88f	81	16	that	that	WDT
cord-018804-wj35q88f	81	17	differ	differ	VBP
cord-018804-wj35q88f	81	18	in	in	IN
cord-018804-wj35q88f	81	19	one	one	CD
cord-018804-wj35q88f	81	20	or	or	CC
cord-018804-wj35q88f	81	21	several	several	JJ
cord-018804-wj35q88f	81	22	nucleotide	nucleotide	JJ
cord-018804-wj35q88f	81	23	positions	position	NNS
cord-018804-wj35q88f	81	24	that	that	WDT
cord-018804-wj35q88f	81	25	can	can	MD
cord-018804-wj35q88f	81	26	be	be	VB
cord-018804-wj35q88f	81	27	responsible	responsible	JJ
cord-018804-wj35q88f	81	28	for	for	IN
cord-018804-wj35q88f	81	29	fitness	fitness	NN
cord-018804-wj35q88f	81	30	variations	variation	NNS
cord-018804-wj35q88f	81	31	in	in	IN
cord-018804-wj35q88f	81	32	individual	individual	JJ
cord-018804-wj35q88f	81	33	mutants	mutant	NNS
cord-018804-wj35q88f	81	34	.	.	.
cord-018804-wj35q88f	82	1	The	the	DT
cord-018804-wj35q88f	82	2	number	number	NN
cord-018804-wj35q88f	82	3	of	of	IN
cord-018804-wj35q88f	82	4	nucleotide	nucleotide	JJ
cord-018804-wj35q88f	82	5	differences	difference	NNS
cord-018804-wj35q88f	82	6	between	between	IN
cord-018804-wj35q88f	82	7	two	two	CD
cord-018804-wj35q88f	82	8	sequences	sequence	NNS
cord-018804-wj35q88f	82	9	is	be	VBZ
cord-018804-wj35q88f	82	10	called	call	VBN
cord-018804-wj35q88f	82	11	the	the	DT
cord-018804-wj35q88f	82	12	Hamming	Hamming	NNP
cord-018804-wj35q88f	82	13	distance	distance	NN
cord-018804-wj35q88f	82	14	.	.	.
cord-018804-wj35q88f	83	1	The	the	DT
cord-018804-wj35q88f	83	2	consensus	consensus	NN
cord-018804-wj35q88f	83	3	sequence	sequence	NN
cord-018804-wj35q88f	83	4	is	be	VBZ
cord-018804-wj35q88f	83	5	defined	define	VBN
cord-018804-wj35q88f	83	6	as	as	IN
cord-018804-wj35q88f	83	7	the	the	DT
cord-018804-wj35q88f	83	8	sequence	sequence	NN
cord-018804-wj35q88f	83	9	of	of	IN
cord-018804-wj35q88f	83	10	the	the	DT
cord-018804-wj35q88f	83	11	most	most	RBS
cord-018804-wj35q88f	83	12	represented	represent	VBN
cord-018804-wj35q88f	83	13	nucleotides	nucleotide	NNS
cord-018804-wj35q88f	83	14	at	at	IN
cord-018804-wj35q88f	83	15	each	each	DT
cord-018804-wj35q88f	83	16	genomic	genomic	JJ
cord-018804-wj35q88f	83	17	position	position	NN
cord-018804-wj35q88f	83	18	in	in	IN
cord-018804-wj35q88f	83	19	the	the	DT
cord-018804-wj35q88f	83	20	ensemble	ensemble	NN
cord-018804-wj35q88f	83	21	of	of	IN
cord-018804-wj35q88f	83	22	genomes	genome	NNS
cord-018804-wj35q88f	83	23	constituting	constitute	VBG
cord-018804-wj35q88f	83	24	the	the	DT
cord-018804-wj35q88f	83	25	population	population	NN
cord-018804-wj35q88f	83	26	.	.	.
cord-018804-wj35q88f	84	1	The	the	DT
cord-018804-wj35q88f	84	2	correspondence	correspondence	NN
cord-018804-wj35q88f	84	3	between	between	IN
cord-018804-wj35q88f	84	4	fitness	fitness	NN
cord-018804-wj35q88f	84	5	values	value	NNS
cord-018804-wj35q88f	84	6	and	and	CC
cord-018804-wj35q88f	84	7	sequences	sequence	NNS
cord-018804-wj35q88f	84	8	(	(	-LRB-
cord-018804-wj35q88f	84	9	or	or	CC
cord-018804-wj35q88f	84	10	between	between	IN
cord-018804-wj35q88f	84	11	phenotypes	phenotype	NNS
cord-018804-wj35q88f	84	12	and	and	CC
cord-018804-wj35q88f	84	13	genotypes	genotype	NNS
cord-018804-wj35q88f	84	14	)	)	-RRB-
cord-018804-wj35q88f	84	15	reveals	reveal	VBZ
cord-018804-wj35q88f	84	16	that	that	IN
cord-018804-wj35q88f	84	17	fitness	fitness	NN
cord-018804-wj35q88f	84	18	landscapes	landscape	NNS
cord-018804-wj35q88f	84	19	(	(	-LRB-
cord-018804-wj35q88f	84	20	a	a	DT
cord-018804-wj35q88f	84	21	surface	surface	NN
cord-018804-wj35q88f	84	22	in	in	IN
cord-018804-wj35q88f	84	23	the	the	DT
cord-018804-wj35q88f	84	24	genotype	genotype	NN
cord-018804-wj35q88f	84	25	space	space	NN
cord-018804-wj35q88f	84	26	representing	represent	VBG
cord-018804-wj35q88f	84	27	the	the	DT
cord-018804-wj35q88f	84	28	fitness	fitness	NN
cord-018804-wj35q88f	84	29	of	of	IN
cord-018804-wj35q88f	84	30	each	each	DT
cord-018804-wj35q88f	84	31	genotype	genotype	NN
cord-018804-wj35q88f	84	32	as	as	IN
cord-018804-wj35q88f	84	33	a	a	DT
cord-018804-wj35q88f	84	34	point	point	NN
cord-018804-wj35q88f	84	35	placed	place	VBN
cord-018804-wj35q88f	84	36	at	at	IN
cord-018804-wj35q88f	84	37	a	a	DT
cord-018804-wj35q88f	84	38	different	different	JJ
cord-018804-wj35q88f	84	39	height	height	NN
cord-018804-wj35q88f	84	40	)	)	-RRB-
cord-018804-wj35q88f	84	41	are	be	VBP
cord-018804-wj35q88f	84	42	rather	rather	RB
cord-018804-wj35q88f	84	43	rugged	rugged	JJ
cord-018804-wj35q88f	84	44	,	,	,
cord-018804-wj35q88f	84	45	since	since	IN
cord-018804-wj35q88f	84	46	relatively	relatively	RB
cord-018804-wj35q88f	84	47	small	small	JJ
cord-018804-wj35q88f	84	48	sequence	sequence	NN
cord-018804-wj35q88f	84	49	differences	difference	NNS
cord-018804-wj35q88f	84	50	can	can	MD
cord-018804-wj35q88f	84	51	cause	cause	VB
cord-018804-wj35q88f	84	52	great	great	JJ
cord-018804-wj35q88f	84	53	differences	difference	NNS
cord-018804-wj35q88f	84	54	in	in	IN
cord-018804-wj35q88f	84	55	fitness	fitness	NN
cord-018804-wj35q88f	84	56	values	value	NNS
cord-018804-wj35q88f	84	57	.	.	.
cord-018804-wj35q88f	85	1	Analysis	Analysis	NNP
cord-018804-wj35q88f	85	2	of	of	IN
cord-018804-wj35q88f	85	3	RNA	RNA	NNP
cord-018804-wj35q88f	85	4	virus	virus	NN
cord-018804-wj35q88f	85	5	populations	population	NNS
cord-018804-wj35q88f	85	6	,	,	,
cord-018804-wj35q88f	85	7	either	either	CC
cord-018804-wj35q88f	85	8	at	at	IN
cord-018804-wj35q88f	85	9	the	the	DT
cord-018804-wj35q88f	85	10	phenotypic	phenotypic	JJ
cord-018804-wj35q88f	85	11	or	or	CC
cord-018804-wj35q88f	85	12	genotypic	genotypic	JJ
cord-018804-wj35q88f	85	13	level	level	NN
cord-018804-wj35q88f	85	14	showed	show	VBD
cord-018804-wj35q88f	85	15	that	that	IN
cord-018804-wj35q88f	85	16	these	these	DT
cord-018804-wj35q88f	85	17	populations	population	NNS
cord-018804-wj35q88f	85	18	have	have	VBP
cord-018804-wj35q88f	85	19	a	a	DT
cord-018804-wj35q88f	85	20	structure	structure	NN
cord-018804-wj35q88f	85	21	similar	similar	JJ
cord-018804-wj35q88f	85	22	to	to	IN
cord-018804-wj35q88f	85	23	the	the	DT
cord-018804-wj35q88f	85	24	molecular	molecular	JJ
cord-018804-wj35q88f	85	25	quasi	quasi	JJ
cord-018804-wj35q88f	85	26	-	-	HYPH
cord-018804-wj35q88f	85	27	species	specie	NNS
cord-018804-wj35q88f	85	28	described	describe	VBN
cord-018804-wj35q88f	85	29	theoretically	theoretically	RB
cord-018804-wj35q88f	85	30	[	[	-LRB-
cord-018804-wj35q88f	85	31	20	20	CD
cord-018804-wj35q88f	85	32	,	,	,
cord-018804-wj35q88f	85	33	21	21	CD
cord-018804-wj35q88f	85	34	]	]	-RRB-
cord-018804-wj35q88f	85	35	.	.	.
cord-018804-wj35q88f	86	1	They	-PRON-	PRP
cord-018804-wj35q88f	86	2	present	present	VBP
cord-018804-wj35q88f	86	3	a	a	DT
cord-018804-wj35q88f	86	4	master	master	NN
cord-018804-wj35q88f	86	5	sequence	sequence	NN
cord-018804-wj35q88f	86	6	surrounded	surround	VBN
cord-018804-wj35q88f	86	7	by	by	IN
cord-018804-wj35q88f	86	8	a	a	DT
cord-018804-wj35q88f	86	9	mutant	mutant	JJ
cord-018804-wj35q88f	86	10	cloud	cloud	NN
cord-018804-wj35q88f	86	11	and	and	CC
cord-018804-wj35q88f	86	12	,	,	,
cord-018804-wj35q88f	86	13	in	in	IN
cord-018804-wj35q88f	86	14	the	the	DT
cord-018804-wj35q88f	86	15	absence	absence	NN
cord-018804-wj35q88f	86	16	of	of	IN
cord-018804-wj35q88f	86	17	a	a	DT
cord-018804-wj35q88f	86	18	cloning	cloning	NN
cord-018804-wj35q88f	86	19	method	method	NN
cord-018804-wj35q88f	86	20	to	to	IN
cord-018804-wj35q88f	86	21	separate	separate	JJ
cord-018804-wj35q88f	86	22	individual	individual	JJ
cord-018804-wj35q88f	86	23	genomes	genome	NNS
cord-018804-wj35q88f	86	24	,	,	,
cord-018804-wj35q88f	86	25	only	only	RB
cord-018804-wj35q88f	86	26	the	the	DT
cord-018804-wj35q88f	86	27	consensus	consensus	NN
cord-018804-wj35q88f	86	28	sequence	sequence	NN
cord-018804-wj35q88f	86	29	can	can	MD
cord-018804-wj35q88f	86	30	be	be	VB
cord-018804-wj35q88f	86	31	determined	determine	VBN
cord-018804-wj35q88f	86	32	.	.	.
cord-018804-wj35q88f	87	1	However	however	RB
cord-018804-wj35q88f	87	2	,	,	,
cord-018804-wj35q88f	87	3	two	two	CD
cord-018804-wj35q88f	87	4	main	main	JJ
cord-018804-wj35q88f	87	5	differences	difference	NNS
cord-018804-wj35q88f	87	6	have	have	VBP
cord-018804-wj35q88f	87	7	to	to	TO
cord-018804-wj35q88f	87	8	be	be	VB
cord-018804-wj35q88f	87	9	taken	take	VBN
cord-018804-wj35q88f	87	10	into	into	IN
cord-018804-wj35q88f	87	11	account	account	NN
cord-018804-wj35q88f	87	12	when	when	WRB
cord-018804-wj35q88f	87	13	comparing	compare	VBG
cord-018804-wj35q88f	87	14	theoretical	theoretical	JJ
cord-018804-wj35q88f	87	15	and	and	CC
cord-018804-wj35q88f	87	16	viral	viral	JJ
cord-018804-wj35q88f	87	17	quasi	quasi	JJ
cord-018804-wj35q88f	87	18	-	-	NNS
cord-018804-wj35q88f	87	19	species	specie	NNS
cord-018804-wj35q88f	87	20	.	.	.
cord-018804-wj35q88f	88	1	The	the	DT
cord-018804-wj35q88f	88	2	first	first	JJ
cord-018804-wj35q88f	88	3	one	one	NN
cord-018804-wj35q88f	88	4	is	be	VBZ
cord-018804-wj35q88f	88	5	that	that	IN
cord-018804-wj35q88f	88	6	viral	viral	JJ
cord-018804-wj35q88f	88	7	quasi	quasi	JJ
cord-018804-wj35q88f	88	8	-	-	NNS
cord-018804-wj35q88f	88	9	species	specie	NNS
cord-018804-wj35q88f	88	10	usually	usually	RB
cord-018804-wj35q88f	88	11	are	be	VBP
cord-018804-wj35q88f	88	12	not	not	RB
cord-018804-wj35q88f	88	13	equilibrium	equilibrium	JJ
cord-018804-wj35q88f	88	14	populations	population	NNS
cord-018804-wj35q88f	88	15	because	because	IN
cord-018804-wj35q88f	88	16	viruses	virus	NNS
cord-018804-wj35q88f	88	17	are	be	VBP
cord-018804-wj35q88f	88	18	continually	continually	RB
cord-018804-wj35q88f	88	19	confronted	confront	VBN
cord-018804-wj35q88f	88	20	with	with	IN
cord-018804-wj35q88f	88	21	many	many	JJ
cord-018804-wj35q88f	88	22	environmental	environmental	JJ
cord-018804-wj35q88f	88	23	perturbations	perturbation	NNS
cord-018804-wj35q88f	88	24	that	that	WDT
cord-018804-wj35q88f	88	25	cause	cause	VBP
cord-018804-wj35q88f	88	26	variations	variation	NNS
cord-018804-wj35q88f	88	27	in	in	IN
cord-018804-wj35q88f	88	28	the	the	DT
cord-018804-wj35q88f	88	29	fitness	fitness	NN
cord-018804-wj35q88f	88	30	distribution	distribution	NN
cord-018804-wj35q88f	88	31	of	of	IN
cord-018804-wj35q88f	88	32	the	the	DT
cord-018804-wj35q88f	88	33	population	population	NN
cord-018804-wj35q88f	88	34	.	.	.
cord-018804-wj35q88f	89	1	The	the	DT
cord-018804-wj35q88f	89	2	second	second	JJ
cord-018804-wj35q88f	89	3	difference	difference	NN
cord-018804-wj35q88f	89	4	is	be	VBZ
cord-018804-wj35q88f	89	5	that	that	IN
cord-018804-wj35q88f	89	6	viral	viral	JJ
cord-018804-wj35q88f	89	7	fitness	fitness	NN
cord-018804-wj35q88f	89	8	is	be	VBZ
cord-018804-wj35q88f	89	9	not	not	RB
cord-018804-wj35q88f	89	10	only	only	RB
cord-018804-wj35q88f	89	11	determined	determine	VBN
cord-018804-wj35q88f	89	12	by	by	IN
cord-018804-wj35q88f	89	13	the	the	DT
cord-018804-wj35q88f	89	14	genomic	genomic	JJ
cord-018804-wj35q88f	89	15	replicative	replicative	JJ
cord-018804-wj35q88f	89	16	ability	ability	NN
cord-018804-wj35q88f	89	17	.	.	.
cord-018804-wj35q88f	90	1	In	in	IN
cord-018804-wj35q88f	90	2	spite	spite	NN
cord-018804-wj35q88f	90	3	of	of	IN
cord-018804-wj35q88f	90	4	its	-PRON-	PRP$
cord-018804-wj35q88f	90	5	simplicity	simplicity	NN
cord-018804-wj35q88f	90	6	,	,	,
cord-018804-wj35q88f	90	7	a	a	DT
cord-018804-wj35q88f	90	8	virus	virus	NN
cord-018804-wj35q88f	90	9	must	must	MD
cord-018804-wj35q88f	90	10	complete	complete	VB
cord-018804-wj35q88f	90	11	successfully	successfully	RB
cord-018804-wj35q88f	90	12	many	many	JJ
cord-018804-wj35q88f	90	13	processes	process	NNS
cord-018804-wj35q88f	90	14	to	to	TO
cord-018804-wj35q88f	90	15	originate	originate	VB
cord-018804-wj35q88f	90	16	an	an	DT
cord-018804-wj35q88f	90	17	infective	infective	JJ
cord-018804-wj35q88f	90	18	progeny	progeny	NN
cord-018804-wj35q88f	90	19	.	.	.
cord-018804-wj35q88f	91	1	These	these	DT
cord-018804-wj35q88f	91	2	include	include	VBP
cord-018804-wj35q88f	91	3	recognition	recognition	NN
cord-018804-wj35q88f	91	4	of	of	IN
cord-018804-wj35q88f	91	5	the	the	DT
cord-018804-wj35q88f	91	6	cellular	cellular	JJ
cord-018804-wj35q88f	91	7	receptors	receptor	NNS
cord-018804-wj35q88f	91	8	,	,	,
cord-018804-wj35q88f	91	9	uncoating	uncoating	NN
cord-018804-wj35q88f	91	10	and	and	CC
cord-018804-wj35q88f	91	11	release	release	NN
cord-018804-wj35q88f	91	12	of	of	IN
cord-018804-wj35q88f	91	13	the	the	DT
cord-018804-wj35q88f	91	14	nucleic	nucleic	JJ
cord-018804-wj35q88f	91	15	acid	acid	NN
cord-018804-wj35q88f	91	16	inside	inside	IN
cord-018804-wj35q88f	91	17	the	the	DT
cord-018804-wj35q88f	91	18	cell	cell	NN
cord-018804-wj35q88f	91	19	,	,	,
cord-018804-wj35q88f	91	20	interaction	interaction	NN
cord-018804-wj35q88f	91	21	with	with	IN
cord-018804-wj35q88f	91	22	many	many	JJ
cord-018804-wj35q88f	91	23	enzymes	enzyme	NNS
cord-018804-wj35q88f	91	24	and	and	CC
cord-018804-wj35q88f	91	25	cellular	cellular	JJ
cord-018804-wj35q88f	91	26	structures	structure	NNS
cord-018804-wj35q88f	91	27	,	,	,
cord-018804-wj35q88f	91	28	correct	correct	JJ
cord-018804-wj35q88f	91	29	assembly	assembly	NN
cord-018804-wj35q88f	91	30	to	to	TO
cord-018804-wj35q88f	91	31	give	give	VB
cord-018804-wj35q88f	91	32	rise	rise	NN
cord-018804-wj35q88f	91	33	to	to	IN
cord-018804-wj35q88f	91	34	new	new	JJ
cord-018804-wj35q88f	91	35	viruses	virus	NNS
cord-018804-wj35q88f	91	36	and	and	CC
cord-018804-wj35q88f	91	37	exit	exit	NN
cord-018804-wj35q88f	91	38	out	out	IN
cord-018804-wj35q88f	91	39	of	of	IN
cord-018804-wj35q88f	91	40	the	the	DT
cord-018804-wj35q88f	91	41	cell	cell	NN
cord-018804-wj35q88f	91	42	.	.	.
cord-018804-wj35q88f	92	1	The	the	DT
cord-018804-wj35q88f	92	2	ability	ability	NN
cord-018804-wj35q88f	92	3	of	of	IN
cord-018804-wj35q88f	92	4	a	a	DT
cord-018804-wj35q88f	92	5	virus	virus	NN
cord-018804-wj35q88f	92	6	to	to	TO
cord-018804-wj35q88f	92	7	perform	perform	VB
cord-018804-wj35q88f	92	8	correctly	correctly	RB
cord-018804-wj35q88f	92	9	all	all	PDT
cord-018804-wj35q88f	92	10	these	these	DT
cord-018804-wj35q88f	92	11	processes	process	NNS
cord-018804-wj35q88f	92	12	,	,	,
cord-018804-wj35q88f	92	13	together	together	RB
cord-018804-wj35q88f	92	14	with	with	IN
cord-018804-wj35q88f	92	15	the	the	DT
cord-018804-wj35q88f	92	16	replicative	replicative	JJ
cord-018804-wj35q88f	92	17	ability	ability	NN
cord-018804-wj35q88f	92	18	of	of	IN
cord-018804-wj35q88f	92	19	its	-PRON-	PRP$
cord-018804-wj35q88f	92	20	genome	genome	NN
cord-018804-wj35q88f	92	21	,	,	,
cord-018804-wj35q88f	92	22	is	be	VBZ
cord-018804-wj35q88f	92	23	what	what	WP
cord-018804-wj35q88f	92	24	determines	determine	VBZ
cord-018804-wj35q88f	92	25	its	-PRON-	PRP$
cord-018804-wj35q88f	92	26	fitness	fitness	NN
cord-018804-wj35q88f	92	27	value	value	NN
cord-018804-wj35q88f	92	28	.	.	.
cord-018804-wj35q88f	93	1	These	these	DT
cord-018804-wj35q88f	93	2	differences	difference	NNS
cord-018804-wj35q88f	93	3	introduce	introduce	VBP
cord-018804-wj35q88f	93	4	uncertainties	uncertainty	NNS
cord-018804-wj35q88f	93	5	and	and	CC
cord-018804-wj35q88f	93	6	additional	additional	JJ
cord-018804-wj35q88f	93	7	complexity	complexity	NN
cord-018804-wj35q88f	93	8	to	to	IN
cord-018804-wj35q88f	93	9	viral	viral	JJ
cord-018804-wj35q88f	93	10	evolution	evolution	NN
cord-018804-wj35q88f	93	11	compared	compare	VBN
cord-018804-wj35q88f	93	12	to	to	IN
cord-018804-wj35q88f	93	13	molecular	molecular	JJ
cord-018804-wj35q88f	93	14	evolution	evolution	NN
cord-018804-wj35q88f	93	15	described	describe	VBN
cord-018804-wj35q88f	93	16	theoretically	theoretically	RB
cord-018804-wj35q88f	93	17	.	.	.
cord-018804-wj35q88f	94	1	Viral	viral	JJ
cord-018804-wj35q88f	94	2	quasi	quasi	JJ
cord-018804-wj35q88f	94	3	-	-	HYPH
cord-018804-wj35q88f	94	4	species	specie	NNS
cord-018804-wj35q88f	94	5	constitute	constitute	VBP
cord-018804-wj35q88f	94	6	very	very	RB
cord-018804-wj35q88f	94	7	dynamical	dynamical	JJ
cord-018804-wj35q88f	94	8	structures	structure	NNS
cord-018804-wj35q88f	94	9	in	in	IN
cord-018804-wj35q88f	94	10	which	which	WDT
cord-018804-wj35q88f	94	11	the	the	DT
cord-018804-wj35q88f	94	12	processes	process	NNS
cord-018804-wj35q88f	94	13	of	of	IN
cord-018804-wj35q88f	94	14	generation	generation	NN
cord-018804-wj35q88f	94	15	of	of	IN
cord-018804-wj35q88f	94	16	new	new	JJ
cord-018804-wj35q88f	94	17	mutants	mutant	NNS
cord-018804-wj35q88f	94	18	,	,	,
cord-018804-wj35q88f	94	19	selection	selection	NN
cord-018804-wj35q88f	94	20	of	of	IN
cord-018804-wj35q88f	94	21	the	the	DT
cord-018804-wj35q88f	94	22	best	well	RBS
cord-018804-wj35q88f	94	23	adapted	adapt	VBN
cord-018804-wj35q88f	94	24	and	and	CC
cord-018804-wj35q88f	94	25	elimination	elimination	NN
cord-018804-wj35q88f	94	26	of	of	IN
cord-018804-wj35q88f	94	27	the	the	DT
cord-018804-wj35q88f	94	28	less	less	RBR
cord-018804-wj35q88f	94	29	fit	fit	JJ
cord-018804-wj35q88f	94	30	are	be	VBP
cord-018804-wj35q88f	94	31	continuously	continuously	RB
cord-018804-wj35q88f	94	32	acting	act	VBG
cord-018804-wj35q88f	94	33	.	.	.
cord-018804-wj35q88f	95	1	Quasi	quasi	JJ
cord-018804-wj35q88f	95	2	-	-	NN
cord-018804-wj35q88f	95	3	species	specie	NNS
cord-018804-wj35q88f	95	4	replicating	replicate	VBG
cord-018804-wj35q88f	95	5	during	during	IN
cord-018804-wj35q88f	95	6	a	a	DT
cord-018804-wj35q88f	95	7	long	long	JJ
cord-018804-wj35q88f	95	8	time	time	NN
cord-018804-wj35q88f	95	9	in	in	IN
cord-018804-wj35q88f	95	10	a	a	DT
cord-018804-wj35q88f	95	11	near	near	JJ
cord-018804-wj35q88f	95	12	-	-	HYPH
cord-018804-wj35q88f	95	13	constant	constant	JJ
cord-018804-wj35q88f	95	14	environment	environment	NN
cord-018804-wj35q88f	95	15	in	in	IN
cord-018804-wj35q88f	95	16	the	the	DT
cord-018804-wj35q88f	95	17	absence	absence	NN
cord-018804-wj35q88f	95	18	of	of	IN
cord-018804-wj35q88f	95	19	large	large	JJ
cord-018804-wj35q88f	95	20	population	population	NN
cord-018804-wj35q88f	95	21	size	size	NN
cord-018804-wj35q88f	95	22	fluctuations	fluctuation	NNS
cord-018804-wj35q88f	95	23	can	can	MD
cord-018804-wj35q88f	95	24	present	present	VB
cord-018804-wj35q88f	95	25	a	a	DT
cord-018804-wj35q88f	95	26	low	low	JJ
cord-018804-wj35q88f	95	27	rate	rate	NN
cord-018804-wj35q88f	95	28	of	of	IN
cord-018804-wj35q88f	95	29	fixation	fixation	NN
cord-018804-wj35q88f	95	30	of	of	IN
cord-018804-wj35q88f	95	31	mutations	mutation	NNS
cord-018804-wj35q88f	95	32	in	in	IN
cord-018804-wj35q88f	95	33	the	the	DT
cord-018804-wj35q88f	95	34	consensus	consensus	NN
cord-018804-wj35q88f	95	35	sequence	sequence	NN
cord-018804-wj35q88f	95	36	,	,	,
cord-018804-wj35q88f	95	37	despite	despite	IN
cord-018804-wj35q88f	95	38	the	the	DT
cord-018804-wj35q88f	95	39	continuous	continuous	JJ
cord-018804-wj35q88f	95	40	occurrence	occurrence	NN
cord-018804-wj35q88f	95	41	of	of	IN
cord-018804-wj35q88f	95	42	mutants	mutant	NNS
cord-018804-wj35q88f	95	43	that	that	WDT
cord-018804-wj35q88f	95	44	is	be	VBZ
cord-018804-wj35q88f	95	45	characteristic	characteristic	JJ
cord-018804-wj35q88f	95	46	of	of	IN
cord-018804-wj35q88f	95	47	the	the	DT
cord-018804-wj35q88f	95	48	underlying	underlie	VBG
cord-018804-wj35q88f	95	49	dynamics	dynamic	NNS
cord-018804-wj35q88f	95	50	of	of	IN
cord-018804-wj35q88f	95	51	the	the	DT
cord-018804-wj35q88f	95	52	population	population	NN
cord-018804-wj35q88f	95	53	.	.	.
cord-018804-wj35q88f	96	1	In	in	IN
cord-018804-wj35q88f	96	2	this	this	DT
cord-018804-wj35q88f	96	3	case	case	NN
cord-018804-wj35q88f	96	4	,	,	,
cord-018804-wj35q88f	96	5	the	the	DT
cord-018804-wj35q88f	96	6	quasi	quasi	JJ
cord-018804-wj35q88f	96	7	-	-	NNS
cord-018804-wj35q88f	96	8	species	species	JJ
cord-018804-wj35q88f	96	9	is	be	VBZ
cord-018804-wj35q88f	96	10	well	well	RB
cord-018804-wj35q88f	96	11	adapted	adapt	VBN
cord-018804-wj35q88f	96	12	to	to	IN
cord-018804-wj35q88f	96	13	the	the	DT
cord-018804-wj35q88f	96	14	environment	environment	NN
cord-018804-wj35q88f	96	15	and	and	CC
cord-018804-wj35q88f	96	16	can	can	MD
cord-018804-wj35q88f	96	17	maintain	maintain	VB
cord-018804-wj35q88f	96	18	a	a	DT
cord-018804-wj35q88f	96	19	low	low	JJ
cord-018804-wj35q88f	96	20	rate	rate	NN
cord-018804-wj35q88f	96	21	of	of	IN
cord-018804-wj35q88f	96	22	evolution	evolution	NN
cord-018804-wj35q88f	96	23	,	,	,
cord-018804-wj35q88f	96	24	as	as	IN
cord-018804-wj35q88f	96	25	determined	determine	VBN
cord-018804-wj35q88f	96	26	by	by	IN
cord-018804-wj35q88f	96	27	the	the	DT
cord-018804-wj35q88f	96	28	stability	stability	NN
cord-018804-wj35q88f	96	29	of	of	IN
cord-018804-wj35q88f	96	30	the	the	DT
cord-018804-wj35q88f	96	31	consensus	consensus	NN
cord-018804-wj35q88f	96	32	sequence	sequence	NN
cord-018804-wj35q88f	96	33	.	.	.
cord-018804-wj35q88f	97	1	Many	many	JJ
cord-018804-wj35q88f	97	2	of	of	IN
cord-018804-wj35q88f	97	3	the	the	DT
cord-018804-wj35q88f	97	4	mutants	mutant	NNS
cord-018804-wj35q88f	97	5	generated	generate	VBN
cord-018804-wj35q88f	97	6	are	be	VBP
cord-018804-wj35q88f	97	7	lethal	lethal	JJ
cord-018804-wj35q88f	97	8	or	or	CC
cord-018804-wj35q88f	97	9	very	very	RB
cord-018804-wj35q88f	97	10	deleterious	deleterious	JJ
cord-018804-wj35q88f	97	11	and	and	CC
cord-018804-wj35q88f	97	12	are	be	VBP
cord-018804-wj35q88f	97	13	eliminated	eliminate	VBN
cord-018804-wj35q88f	97	14	or	or	CC
cord-018804-wj35q88f	97	15	maintained	maintain	VBN
cord-018804-wj35q88f	97	16	at	at	IN
cord-018804-wj35q88f	97	17	low	low	JJ
cord-018804-wj35q88f	97	18	frequency	frequency	NN
cord-018804-wj35q88f	97	19	by	by	IN
cord-018804-wj35q88f	97	20	the	the	DT
cord-018804-wj35q88f	97	21	action	action	NN
cord-018804-wj35q88f	97	22	of	of	IN
cord-018804-wj35q88f	97	23	negative	negative	JJ
cord-018804-wj35q88f	97	24	selection	selection	NN
cord-018804-wj35q88f	97	25	.	.	.
cord-018804-wj35q88f	98	1	In	in	IN
cord-018804-wj35q88f	98	2	contrast	contrast	NN
cord-018804-wj35q88f	98	3	,	,	,
cord-018804-wj35q88f	98	4	mutants	mutant	NNS
cord-018804-wj35q88f	98	5	with	with	IN
cord-018804-wj35q88f	98	6	a	a	DT
cord-018804-wj35q88f	98	7	selective	selective	JJ
cord-018804-wj35q88f	98	8	advantage	advantage	NN
cord-018804-wj35q88f	98	9	can	can	MD
cord-018804-wj35q88f	98	10	be	be	VB
cord-018804-wj35q88f	98	11	present	present	JJ
cord-018804-wj35q88f	98	12	at	at	IN
cord-018804-wj35q88f	98	13	high	high	JJ
cord-018804-wj35q88f	98	14	frequency	frequency	NN
cord-018804-wj35q88f	98	15	,	,	,
cord-018804-wj35q88f	98	16	even	even	RB
cord-018804-wj35q88f	98	17	if	if	IN
cord-018804-wj35q88f	98	18	they	-PRON-	PRP
cord-018804-wj35q88f	98	19	are	be	VBP
cord-018804-wj35q88f	98	20	produced	produce	VBN
cord-018804-wj35q88f	98	21	at	at	IN
cord-018804-wj35q88f	98	22	a	a	DT
cord-018804-wj35q88f	98	23	low	low	JJ
cord-018804-wj35q88f	98	24	rate	rate	NN
cord-018804-wj35q88f	98	25	[	[	-LRB-
cord-018804-wj35q88f	98	26	20	20	CD
cord-018804-wj35q88f	98	27	]	]	-RRB-
cord-018804-wj35q88f	98	28	.	.	.
cord-018804-wj35q88f	99	1	Neutral	neutral	JJ
cord-018804-wj35q88f	99	2	mutations	mutation	NNS
cord-018804-wj35q88f	99	3	are	be	VBP
cord-018804-wj35q88f	99	4	thought	think	VBN
cord-018804-wj35q88f	99	5	to	to	TO
cord-018804-wj35q88f	99	6	be	be	VB
cord-018804-wj35q88f	99	7	very	very	RB
cord-018804-wj35q88f	99	8	restricted	restricted	JJ
cord-018804-wj35q88f	99	9	in	in	IN
cord-018804-wj35q88f	99	10	RNA	RNA	NNP
cord-018804-wj35q88f	99	11	viruses	virus	NNS
cord-018804-wj35q88f	99	12	because	because	IN
cord-018804-wj35q88f	99	13	of	of	IN
cord-018804-wj35q88f	99	14	their	-PRON-	PRP$
cord-018804-wj35q88f	99	15	highly	highly	RB
cord-018804-wj35q88f	99	16	compact	compact	JJ
cord-018804-wj35q88f	99	17	genomes	genome	NNS
cord-018804-wj35q88f	99	18	[	[	-LRB-
cord-018804-wj35q88f	99	19	22	22	CD
cord-018804-wj35q88f	99	20	]	]	-RRB-
cord-018804-wj35q88f	99	21	.	.	.
cord-018804-wj35q88f	100	1	Low	low	JJ
cord-018804-wj35q88f	100	2	rates	rate	NNS
cord-018804-wj35q88f	100	3	of	of	IN
cord-018804-wj35q88f	100	4	evolution	evolution	NN
cord-018804-wj35q88f	100	5	have	have	VBP
cord-018804-wj35q88f	100	6	been	be	VBN
cord-018804-wj35q88f	100	7	described	describe	VBN
cord-018804-wj35q88f	100	8	for	for	IN
cord-018804-wj35q88f	100	9	viruses	virus	NNS
cord-018804-wj35q88f	100	10	well	well	RB
cord-018804-wj35q88f	100	11	adapted	adapt	VBN
cord-018804-wj35q88f	100	12	to	to	IN
cord-018804-wj35q88f	100	13	their	-PRON-	PRP$
cord-018804-wj35q88f	100	14	animal	animal	NN
cord-018804-wj35q88f	100	15	reservoir	reservoir	NN
cord-018804-wj35q88f	100	16	(	(	-LRB-
cord-018804-wj35q88f	100	17	the	the	DT
cord-018804-wj35q88f	100	18	host	host	NN
cord-018804-wj35q88f	100	19	in	in	IN
cord-018804-wj35q88f	100	20	which	which	WDT
cord-018804-wj35q88f	100	21	the	the	DT
cord-018804-wj35q88f	100	22	virus	virus	NN
cord-018804-wj35q88f	100	23	is	be	VBZ
cord-018804-wj35q88f	100	24	usually	usually	RB
cord-018804-wj35q88f	100	25	maintained	maintain	VBN
cord-018804-wj35q88f	100	26	in	in	IN
cord-018804-wj35q88f	100	27	nature	nature	NN
cord-018804-wj35q88f	100	28	)	)	-RRB-
cord-018804-wj35q88f	100	29	as	as	IN
cord-018804-wj35q88f	100	30	influenza	influenza	NN
cord-018804-wj35q88f	100	31	in	in	IN
cord-018804-wj35q88f	100	32	birds	bird	NNS
cord-018804-wj35q88f	100	33	or	or	CC
cord-018804-wj35q88f	100	34	hantavirus	hantavirus	NN
cord-018804-wj35q88f	100	35	in	in	IN
cord-018804-wj35q88f	100	36	rodents	rodent	NNS
cord-018804-wj35q88f	100	37	.	.	.
cord-018804-wj35q88f	101	1	The	the	DT
cord-018804-wj35q88f	101	2	same	same	JJ
cord-018804-wj35q88f	101	3	happens	happen	VBZ
cord-018804-wj35q88f	101	4	in	in	IN
cord-018804-wj35q88f	101	5	the	the	DT
cord-018804-wj35q88f	101	6	laboratory	laboratory	NN
cord-018804-wj35q88f	101	7	,	,	,
cord-018804-wj35q88f	101	8	where	where	WRB
cord-018804-wj35q88f	101	9	viruses	virus	NNS
cord-018804-wj35q88f	101	10	are	be	VBP
cord-018804-wj35q88f	101	11	usually	usually	RB
cord-018804-wj35q88f	101	12	cultivated	cultivate	VBN
cord-018804-wj35q88f	101	13	during	during	IN
cord-018804-wj35q88f	101	14	years	year	NNS
cord-018804-wj35q88f	101	15	in	in	IN
cord-018804-wj35q88f	101	16	the	the	DT
cord-018804-wj35q88f	101	17	same	same	JJ
cord-018804-wj35q88f	101	18	cellular	cellular	JJ
cord-018804-wj35q88f	101	19	type	type	NN
cord-018804-wj35q88f	101	20	.	.	.
cord-018804-wj35q88f	102	1	In	in	IN
cord-018804-wj35q88f	102	2	both	both	DT
cord-018804-wj35q88f	102	3	cases	case	NNS
cord-018804-wj35q88f	102	4	an	an	DT
cord-018804-wj35q88f	102	5	almost	almost	RB
cord-018804-wj35q88f	102	6	invariant	invariant	JJ
cord-018804-wj35q88f	102	7	consensus	consensus	NN
cord-018804-wj35q88f	102	8	sequence	sequence	NN
cord-018804-wj35q88f	102	9	can	can	MD
cord-018804-wj35q88f	102	10	be	be	VB
cord-018804-wj35q88f	102	11	found	find	VBN
cord-018804-wj35q88f	102	12	,	,	,
cord-018804-wj35q88f	102	13	although	although	IN
cord-018804-wj35q88f	102	14	the	the	DT
cord-018804-wj35q88f	102	15	dynamics	dynamic	NNS
cord-018804-wj35q88f	102	16	of	of	IN
cord-018804-wj35q88f	102	17	the	the	DT
cord-018804-wj35q88f	102	18	quasi	quasi	JJ
cord-018804-wj35q88f	102	19	-	-	NNS
cord-018804-wj35q88f	102	20	species	species	JJ
cord-018804-wj35q88f	102	21	is	be	VBZ
cord-018804-wj35q88f	102	22	always	always	RB
cord-018804-wj35q88f	102	23	dominated	dominate	VBN
cord-018804-wj35q88f	102	24	by	by	IN
cord-018804-wj35q88f	102	25	the	the	DT
cord-018804-wj35q88f	102	26	processes	process	NNS
cord-018804-wj35q88f	102	27	of	of	IN
cord-018804-wj35q88f	102	28	mutation	mutation	NN
cord-018804-wj35q88f	102	29	and	and	CC
cord-018804-wj35q88f	102	30	selection	selection	NN
cord-018804-wj35q88f	102	31	acting	act	VBG
cord-018804-wj35q88f	102	32	in	in	IN
cord-018804-wj35q88f	102	33	close	close	JJ
cord-018804-wj35q88f	102	34	concert	concert	NN
cord-018804-wj35q88f	102	35	.	.	.
cord-018804-wj35q88f	103	1	The	the	DT
cord-018804-wj35q88f	103	2	factors	factor	NNS
cord-018804-wj35q88f	103	3	that	that	WDT
cord-018804-wj35q88f	103	4	promote	promote	VBP
cord-018804-wj35q88f	103	5	the	the	DT
cord-018804-wj35q88f	103	6	fixation	fixation	NN
cord-018804-wj35q88f	103	7	of	of	IN
cord-018804-wj35q88f	103	8	mutations	mutation	NNS
cord-018804-wj35q88f	103	9	in	in	IN
cord-018804-wj35q88f	103	10	the	the	DT
cord-018804-wj35q88f	103	11	consensus	consensus	NN
cord-018804-wj35q88f	103	12	sequence	sequence	NN
cord-018804-wj35q88f	103	13	are	be	VBP
cord-018804-wj35q88f	103	14	usually	usually	RB
cord-018804-wj35q88f	103	15	environmental	environmental	JJ
cord-018804-wj35q88f	103	16	changes	change	NNS
cord-018804-wj35q88f	103	17	that	that	WDT
cord-018804-wj35q88f	103	18	favour	favour	VBP
cord-018804-wj35q88f	103	19	the	the	DT
cord-018804-wj35q88f	103	20	selection	selection	NN
cord-018804-wj35q88f	103	21	of	of	IN
cord-018804-wj35q88f	103	22	the	the	DT
cord-018804-wj35q88f	103	23	best	good	JJS
cord-018804-wj35q88f	103	24	adapted	adapt	VBN
cord-018804-wj35q88f	103	25	genomes	genome	NNS
cord-018804-wj35q88f	103	26	in	in	IN
cord-018804-wj35q88f	103	27	the	the	DT
cord-018804-wj35q88f	103	28	new	new	JJ
cord-018804-wj35q88f	103	29	conditions	condition	NNS
cord-018804-wj35q88f	103	30	or	or	CC
cord-018804-wj35q88f	103	31	drastic	drastic	JJ
cord-018804-wj35q88f	103	32	reductions	reduction	NNS
cord-018804-wj35q88f	103	33	in	in	IN
cord-018804-wj35q88f	103	34	the	the	DT
cord-018804-wj35q88f	103	35	number	number	NN
cord-018804-wj35q88f	103	36	of	of	IN
cord-018804-wj35q88f	103	37	individuals	individual	NNS
cord-018804-wj35q88f	103	38	that	that	WDT
cord-018804-wj35q88f	103	39	will	will	MD
cord-018804-wj35q88f	103	40	originate	originate	VB
cord-018804-wj35q88f	103	41	a	a	DT
cord-018804-wj35q88f	103	42	new	new	JJ
cord-018804-wj35q88f	103	43	population	population	NN
cord-018804-wj35q88f	103	44	,	,	,
cord-018804-wj35q88f	103	45	what	what	WP
cord-018804-wj35q88f	103	46	is	be	VBZ
cord-018804-wj35q88f	103	47	called	call	VBN
cord-018804-wj35q88f	103	48	population	population	NN
cord-018804-wj35q88f	103	49	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	103	50	.	.	.
cord-018804-wj35q88f	104	1	The	the	DT
cord-018804-wj35q88f	104	2	occurrence	occurrence	NN
cord-018804-wj35q88f	104	3	of	of	IN
cord-018804-wj35q88f	104	4	genetic	genetic	JJ
cord-018804-wj35q88f	104	5	alterations	alteration	NNS
cord-018804-wj35q88f	104	6	with	with	IN
cord-018804-wj35q88f	104	7	an	an	DT
cord-018804-wj35q88f	104	8	adaptive	adaptive	JJ
cord-018804-wj35q88f	104	9	advantage	advantage	NN
cord-018804-wj35q88f	104	10	in	in	IN
cord-018804-wj35q88f	104	11	the	the	DT
cord-018804-wj35q88f	104	12	absence	absence	NN
cord-018804-wj35q88f	104	13	of	of	IN
cord-018804-wj35q88f	104	14	environmental	environmental	JJ
cord-018804-wj35q88f	104	15	perturbations	perturbation	NNS
cord-018804-wj35q88f	104	16	is	be	VBZ
cord-018804-wj35q88f	104	17	also	also	RB
cord-018804-wj35q88f	104	18	possible	possible	JJ
cord-018804-wj35q88f	104	19	,	,	,
cord-018804-wj35q88f	104	20	although	although	IN
cord-018804-wj35q88f	104	21	it	-PRON-	PRP
cord-018804-wj35q88f	104	22	happens	happen	VBZ
cord-018804-wj35q88f	104	23	more	more	RBR
cord-018804-wj35q88f	104	24	rarely	rarely	RB
cord-018804-wj35q88f	104	25	.	.	.
cord-018804-wj35q88f	105	1	In	in	IN
cord-018804-wj35q88f	105	2	this	this	DT
cord-018804-wj35q88f	105	3	section	section	NN
cord-018804-wj35q88f	105	4	,	,	,
cord-018804-wj35q88f	105	5	we	-PRON-	PRP
cord-018804-wj35q88f	105	6	will	will	MD
cord-018804-wj35q88f	105	7	focus	focus	VB
cord-018804-wj35q88f	105	8	on	on	IN
cord-018804-wj35q88f	105	9	some	some	DT
cord-018804-wj35q88f	105	10	features	feature	NNS
cord-018804-wj35q88f	105	11	that	that	WDT
cord-018804-wj35q88f	105	12	favour	favour	VBP
cord-018804-wj35q88f	105	13	the	the	DT
cord-018804-wj35q88f	105	14	action	action	NN
cord-018804-wj35q88f	105	15	of	of	IN
cord-018804-wj35q88f	105	16	positive	positive	JJ
cord-018804-wj35q88f	105	17	selection	selection	NN
cord-018804-wj35q88f	105	18	and	and	CC
cord-018804-wj35q88f	105	19	amplification	amplification	NN
cord-018804-wj35q88f	105	20	of	of	IN
cord-018804-wj35q88f	105	21	advantageous	advantageous	JJ
cord-018804-wj35q88f	105	22	mutants	mutant	NNS
cord-018804-wj35q88f	105	23	.	.	.
cord-018804-wj35q88f	106	1	We	-PRON-	PRP
cord-018804-wj35q88f	106	2	will	will	MD
cord-018804-wj35q88f	106	3	mention	mention	VB
cord-018804-wj35q88f	106	4	three	three	CD
cord-018804-wj35q88f	106	5	examples	example	NNS
cord-018804-wj35q88f	106	6	that	that	WDT
cord-018804-wj35q88f	106	7	make	make	VBP
cord-018804-wj35q88f	106	8	enormously	enormously	RB
cord-018804-wj35q88f	106	9	difficult	difficult	JJ
cord-018804-wj35q88f	106	10	virus	virus	NN
cord-018804-wj35q88f	106	11	eradication	eradication	NN
cord-018804-wj35q88f	106	12	:	:	:
cord-018804-wj35q88f	106	13	1	1	CD
cord-018804-wj35q88f	106	14	.	.	.
cord-018804-wj35q88f	107	1	Treatment	treatment	NN
cord-018804-wj35q88f	107	2	with	with	IN
cord-018804-wj35q88f	107	3	antiviral	antiviral	JJ
cord-018804-wj35q88f	107	4	drugs	drug	NNS
cord-018804-wj35q88f	107	5	.	.	.
cord-018804-wj35q88f	108	1	When	when	WRB
cord-018804-wj35q88f	108	2	a	a	DT
cord-018804-wj35q88f	108	3	viral	viral	JJ
cord-018804-wj35q88f	108	4	infection	infection	NN
cord-018804-wj35q88f	108	5	is	be	VBZ
cord-018804-wj35q88f	108	6	treated	treat	VBN
cord-018804-wj35q88f	108	7	with	with	IN
cord-018804-wj35q88f	108	8	an	an	DT
cord-018804-wj35q88f	108	9	antiviral	antiviral	JJ
cord-018804-wj35q88f	108	10	agent	agent	NN
cord-018804-wj35q88f	108	11	the	the	DT
cord-018804-wj35q88f	108	12	usual	usual	JJ
cord-018804-wj35q88f	108	13	outcome	outcome	NN
cord-018804-wj35q88f	108	14	is	be	VBZ
cord-018804-wj35q88f	108	15	that	that	IN
cord-018804-wj35q88f	108	16	,	,	,
cord-018804-wj35q88f	108	17	after	after	IN
cord-018804-wj35q88f	108	18	a	a	DT
cord-018804-wj35q88f	108	19	short	short	JJ
cord-018804-wj35q88f	108	20	time	time	NN
cord-018804-wj35q88f	108	21	of	of	IN
cord-018804-wj35q88f	108	22	success	success	NN
cord-018804-wj35q88f	108	23	,	,	,
cord-018804-wj35q88f	108	24	the	the	DT
cord-018804-wj35q88f	108	25	treatment	treatment	NN
cord-018804-wj35q88f	108	26	loses	lose	VBZ
cord-018804-wj35q88f	108	27	its	-PRON-	PRP$
cord-018804-wj35q88f	108	28	efficacy	efficacy	NN
cord-018804-wj35q88f	108	29	.	.	.
cord-018804-wj35q88f	109	1	The	the	DT
cord-018804-wj35q88f	109	2	failure	failure	NN
cord-018804-wj35q88f	109	3	is	be	VBZ
cord-018804-wj35q88f	109	4	generally	generally	RB
cord-018804-wj35q88f	109	5	due	due	JJ
cord-018804-wj35q88f	109	6	to	to	IN
cord-018804-wj35q88f	109	7	the	the	DT
cord-018804-wj35q88f	109	8	presence	presence	NN
cord-018804-wj35q88f	109	9	in	in	IN
cord-018804-wj35q88f	109	10	the	the	DT
cord-018804-wj35q88f	109	11	mutant	mutant	JJ
cord-018804-wj35q88f	109	12	spectrum	spectrum	NN
cord-018804-wj35q88f	109	13	of	of	IN
cord-018804-wj35q88f	109	14	some	some	DT
cord-018804-wj35q88f	109	15	genomes	genome	NNS
cord-018804-wj35q88f	109	16	able	able	JJ
cord-018804-wj35q88f	109	17	to	to	TO
cord-018804-wj35q88f	109	18	resist	resist	VB
cord-018804-wj35q88f	109	19	the	the	DT
cord-018804-wj35q88f	109	20	action	action	NN
cord-018804-wj35q88f	109	21	of	of	IN
cord-018804-wj35q88f	109	22	the	the	DT
cord-018804-wj35q88f	109	23	drug	drug	NN
cord-018804-wj35q88f	109	24	.	.	.
cord-018804-wj35q88f	110	1	Usually	usually	RB
cord-018804-wj35q88f	110	2	,	,	,
cord-018804-wj35q88f	110	3	these	these	DT
cord-018804-wj35q88f	110	4	genomes	genome	NNS
cord-018804-wj35q88f	110	5	have	have	VBP
cord-018804-wj35q88f	110	6	lower	low	JJR
cord-018804-wj35q88f	110	7	fitness	fitness	NN
cord-018804-wj35q88f	110	8	in	in	IN
cord-018804-wj35q88f	110	9	the	the	DT
cord-018804-wj35q88f	110	10	absence	absence	NN
cord-018804-wj35q88f	110	11	of	of	IN
cord-018804-wj35q88f	110	12	the	the	DT
cord-018804-wj35q88f	110	13	drug	drug	NN
cord-018804-wj35q88f	110	14	and	and	CC
cord-018804-wj35q88f	110	15	they	-PRON-	PRP
cord-018804-wj35q88f	110	16	are	be	VBP
cord-018804-wj35q88f	110	17	maintained	maintain	VBN
cord-018804-wj35q88f	110	18	at	at	IN
cord-018804-wj35q88f	110	19	low	low	JJ
cord-018804-wj35q88f	110	20	frequencies	frequency	NNS
cord-018804-wj35q88f	110	21	by	by	IN
cord-018804-wj35q88f	110	22	the	the	DT
cord-018804-wj35q88f	110	23	action	action	NN
cord-018804-wj35q88f	110	24	of	of	IN
cord-018804-wj35q88f	110	25	negative	negative	JJ
cord-018804-wj35q88f	110	26	selection	selection	NN
cord-018804-wj35q88f	110	27	.	.	.
cord-018804-wj35q88f	111	1	The	the	DT
cord-018804-wj35q88f	111	2	presence	presence	NN
cord-018804-wj35q88f	111	3	of	of	IN
cord-018804-wj35q88f	111	4	the	the	DT
cord-018804-wj35q88f	111	5	drug	drug	NN
cord-018804-wj35q88f	111	6	inhibits	inhibit	VBZ
cord-018804-wj35q88f	111	7	the	the	DT
cord-018804-wj35q88f	111	8	replication	replication	NN
cord-018804-wj35q88f	111	9	of	of	IN
cord-018804-wj35q88f	111	10	the	the	DT
cord-018804-wj35q88f	111	11	sensitive	sensitive	JJ
cord-018804-wj35q88f	111	12	genomes	genome	NNS
cord-018804-wj35q88f	111	13	,	,	,
cord-018804-wj35q88f	111	14	but	but	CC
cord-018804-wj35q88f	111	15	not	not	RB
cord-018804-wj35q88f	111	16	of	of	IN
cord-018804-wj35q88f	111	17	the	the	DT
cord-018804-wj35q88f	111	18	resistant	resistant	JJ
cord-018804-wj35q88f	111	19	ones	one	NNS
cord-018804-wj35q88f	111	20	,	,	,
cord-018804-wj35q88f	111	21	which	which	WDT
cord-018804-wj35q88f	111	22	are	be	VBP
cord-018804-wj35q88f	111	23	selected	select	VBN
cord-018804-wj35q88f	111	24	and	and	CC
cord-018804-wj35q88f	111	25	amplified	amplify	VBN
cord-018804-wj35q88f	111	26	.	.	.
cord-018804-wj35q88f	112	1	It	-PRON-	PRP
cord-018804-wj35q88f	112	2	can	can	MD
cord-018804-wj35q88f	112	3	also	also	RB
cord-018804-wj35q88f	112	4	occur	occur	VB
cord-018804-wj35q88f	112	5	that	that	IN
cord-018804-wj35q88f	112	6	,	,	,
cord-018804-wj35q88f	112	7	at	at	IN
cord-018804-wj35q88f	112	8	the	the	DT
cord-018804-wj35q88f	112	9	beginning	beginning	NN
cord-018804-wj35q88f	112	10	of	of	IN
cord-018804-wj35q88f	112	11	the	the	DT
cord-018804-wj35q88f	112	12	treatment	treatment	NN
cord-018804-wj35q88f	112	13	,	,	,
cord-018804-wj35q88f	112	14	no	no	DT
cord-018804-wj35q88f	112	15	drug	drug	NN
cord-018804-wj35q88f	112	16	-	-	HYPH
cord-018804-wj35q88f	112	17	resistant	resistant	JJ
cord-018804-wj35q88f	112	18	genomes	genome	NNS
cord-018804-wj35q88f	112	19	are	be	VBP
cord-018804-wj35q88f	112	20	present	present	JJ
cord-018804-wj35q88f	112	21	in	in	IN
cord-018804-wj35q88f	112	22	the	the	DT
cord-018804-wj35q88f	112	23	population	population	NN
cord-018804-wj35q88f	112	24	.	.	.
cord-018804-wj35q88f	113	1	However	however	RB
cord-018804-wj35q88f	113	2	,	,	,
cord-018804-wj35q88f	113	3	the	the	DT
cord-018804-wj35q88f	113	4	high	high	JJ
cord-018804-wj35q88f	113	5	mutation	mutation	NN
cord-018804-wj35q88f	113	6	rates	rate	NNS
cord-018804-wj35q88f	113	7	and	and	CC
cord-018804-wj35q88f	113	8	large	large	JJ
cord-018804-wj35q88f	113	9	population	population	NN
cord-018804-wj35q88f	113	10	sizes	size	NNS
cord-018804-wj35q88f	113	11	of	of	IN
cord-018804-wj35q88f	113	12	RNA	RNA	NNP
cord-018804-wj35q88f	113	13	viruses	virus	NNS
cord-018804-wj35q88f	113	14	make	make	VBP
cord-018804-wj35q88f	113	15	highly	highly	RB
cord-018804-wj35q88f	113	16	probable	probable	JJ
cord-018804-wj35q88f	113	17	that	that	IN
cord-018804-wj35q88f	113	18	,	,	,
cord-018804-wj35q88f	113	19	after	after	IN
cord-018804-wj35q88f	113	20	a	a	DT
cord-018804-wj35q88f	113	21	variable	variable	JJ
cord-018804-wj35q88f	113	22	time	time	NN
cord-018804-wj35q88f	113	23	lag	lag	NN
cord-018804-wj35q88f	113	24	,	,	,
cord-018804-wj35q88f	113	25	a	a	DT
cord-018804-wj35q88f	113	26	resistant	resistant	JJ
cord-018804-wj35q88f	113	27	mutant	mutant	NN
cord-018804-wj35q88f	113	28	appears	appear	VBZ
cord-018804-wj35q88f	113	29	,	,	,
cord-018804-wj35q88f	113	30	which	which	WDT
cord-018804-wj35q88f	113	31	in	in	IN
cord-018804-wj35q88f	113	32	a	a	DT
cord-018804-wj35q88f	113	33	short	short	JJ
cord-018804-wj35q88f	113	34	time	time	NN
cord-018804-wj35q88f	113	35	can	can	MD
cord-018804-wj35q88f	113	36	dominate	dominate	VB
cord-018804-wj35q88f	113	37	the	the	DT
cord-018804-wj35q88f	113	38	population	population	NN
cord-018804-wj35q88f	113	39	.	.	.
cord-018804-wj35q88f	114	1	Maybe	maybe	RB
cord-018804-wj35q88f	114	2	,	,	,
cord-018804-wj35q88f	114	3	the	the	DT
cord-018804-wj35q88f	114	4	most	most	RBS
cord-018804-wj35q88f	114	5	dramatic	dramatic	JJ
cord-018804-wj35q88f	114	6	example	example	NN
cord-018804-wj35q88f	114	7	of	of	IN
cord-018804-wj35q88f	114	8	drug	drug	NN
cord-018804-wj35q88f	114	9	-	-	HYPH
cord-018804-wj35q88f	114	10	induced	induce	VBN
cord-018804-wj35q88f	114	11	resistance	resistance	NN
cord-018804-wj35q88f	114	12	occurs	occur	VBZ
cord-018804-wj35q88f	114	13	in	in	IN
cord-018804-wj35q88f	114	14	patients	patient	NNS
cord-018804-wj35q88f	114	15	infected	infect	VBN
cord-018804-wj35q88f	114	16	with	with	IN
cord-018804-wj35q88f	114	17	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	114	18	in	in	IN
cord-018804-wj35q88f	114	19	which	which	WDT
cord-018804-wj35q88f	114	20	variants	variant	NNS
cord-018804-wj35q88f	114	21	resistant	resistant	JJ
cord-018804-wj35q88f	114	22	to	to	IN
cord-018804-wj35q88f	114	23	all	all	DT
cord-018804-wj35q88f	114	24	currently	currently	RB
cord-018804-wj35q88f	114	25	used	use	VBN
cord-018804-wj35q88f	114	26	drugs	drug	NNS
cord-018804-wj35q88f	114	27	have	have	VBP
cord-018804-wj35q88f	114	28	been	be	VBN
cord-018804-wj35q88f	114	29	isolated	isolate	VBN
cord-018804-wj35q88f	114	30	[	[	-LRB-
cord-018804-wj35q88f	114	31	23	23	CD
cord-018804-wj35q88f	114	32	,	,	,
cord-018804-wj35q88f	114	33	24	24	CD
cord-018804-wj35q88f	114	34	]	]	-RRB-
cord-018804-wj35q88f	114	35	.	.	.
cord-018804-wj35q88f	115	1	At	at	IN
cord-018804-wj35q88f	115	2	present	present	NN
cord-018804-wj35q88f	115	3	,	,	,
cord-018804-wj35q88f	115	4	the	the	DT
cord-018804-wj35q88f	115	5	most	most	RBS
cord-018804-wj35q88f	115	6	effective	effective	JJ
cord-018804-wj35q88f	115	7	treatment	treatment	NN
cord-018804-wj35q88f	115	8	to	to	TO
cord-018804-wj35q88f	115	9	control	control	VB
cord-018804-wj35q88f	115	10	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	115	11	infection	infection	NN
cord-018804-wj35q88f	115	12	is	be	VBZ
cord-018804-wj35q88f	115	13	the	the	DT
cord-018804-wj35q88f	115	14	so	so	RB
cord-018804-wj35q88f	115	15	called	call	VBN
cord-018804-wj35q88f	115	16	highly	highly	RB
cord-018804-wj35q88f	115	17	active	active	JJ
cord-018804-wj35q88f	115	18	anti	anti	JJ
cord-018804-wj35q88f	115	19	-	-	JJ
cord-018804-wj35q88f	115	20	retroviral	retroviral	JJ
cord-018804-wj35q88f	115	21	therapy	therapy	NN
cord-018804-wj35q88f	115	22	(	(	-LRB-
cord-018804-wj35q88f	115	23	HAART	HAART	NNP
cord-018804-wj35q88f	115	24	)	)	-RRB-
cord-018804-wj35q88f	115	25	,	,	,
cord-018804-wj35q88f	115	26	which	which	WDT
cord-018804-wj35q88f	115	27	involves	involve	VBZ
cord-018804-wj35q88f	115	28	a	a	DT
cord-018804-wj35q88f	115	29	combination	combination	NN
cord-018804-wj35q88f	115	30	of	of	IN
cord-018804-wj35q88f	115	31	several	several	JJ
cord-018804-wj35q88f	115	32	drugs	drug	NNS
cord-018804-wj35q88f	115	33	,	,	,
cord-018804-wj35q88f	115	34	aimed	aim	VBN
cord-018804-wj35q88f	115	35	at	at	IN
cord-018804-wj35q88f	115	36	preventing	prevent	VBG
cord-018804-wj35q88f	115	37	the	the	DT
cord-018804-wj35q88f	115	38	emergence	emergence	NN
cord-018804-wj35q88f	115	39	of	of	IN
cord-018804-wj35q88f	115	40	variants	variant	NNS
cord-018804-wj35q88f	115	41	with	with	IN
cord-018804-wj35q88f	115	42	mutations	mutation	NNS
cord-018804-wj35q88f	115	43	conferring	confer	VBG
cord-018804-wj35q88f	115	44	resistance	resistance	NN
cord-018804-wj35q88f	115	45	to	to	IN
cord-018804-wj35q88f	115	46	all	all	PDT
cord-018804-wj35q88f	115	47	the	the	DT
cord-018804-wj35q88f	115	48	drugs	drug	NNS
cord-018804-wj35q88f	115	49	at	at	IN
cord-018804-wj35q88f	115	50	the	the	DT
cord-018804-wj35q88f	115	51	same	same	JJ
cord-018804-wj35q88f	115	52	time	time	NN
cord-018804-wj35q88f	115	53	.	.	.
cord-018804-wj35q88f	116	1	2	2	LS
cord-018804-wj35q88f	116	2	.	.	.
cord-018804-wj35q88f	117	1	Antigenic	antigenic	JJ
cord-018804-wj35q88f	117	2	drift	drift	NN
cord-018804-wj35q88f	117	3	.	.	.
cord-018804-wj35q88f	118	1	There	there	EX
cord-018804-wj35q88f	118	2	are	be	VBP
cord-018804-wj35q88f	118	3	considerable	considerable	JJ
cord-018804-wj35q88f	118	4	differences	difference	NNS
cord-018804-wj35q88f	118	5	in	in	IN
cord-018804-wj35q88f	118	6	the	the	DT
cord-018804-wj35q88f	118	7	nature	nature	NN
cord-018804-wj35q88f	118	8	and	and	CC
cord-018804-wj35q88f	118	9	duration	duration	NN
cord-018804-wj35q88f	118	10	of	of	IN
cord-018804-wj35q88f	118	11	the	the	DT
cord-018804-wj35q88f	118	12	immune	immune	JJ
cord-018804-wj35q88f	118	13	response	response	NN
cord-018804-wj35q88f	118	14	elicited	elicit	VBN
cord-018804-wj35q88f	118	15	by	by	IN
cord-018804-wj35q88f	118	16	different	different	JJ
cord-018804-wj35q88f	118	17	viruses	virus	NNS
cord-018804-wj35q88f	118	18	[	[	-LRB-
cord-018804-wj35q88f	118	19	25	25	CD
cord-018804-wj35q88f	118	20	]	]	-RRB-
cord-018804-wj35q88f	118	21	.	.	.
cord-018804-wj35q88f	119	1	Some	some	DT
cord-018804-wj35q88f	119	2	human	human	JJ
cord-018804-wj35q88f	119	3	viruses	virus	NNS
cord-018804-wj35q88f	119	4	,	,	,
cord-018804-wj35q88f	119	5	such	such	JJ
cord-018804-wj35q88f	119	6	as	as	IN
cord-018804-wj35q88f	119	7	measles	measle	NNS
cord-018804-wj35q88f	119	8	or	or	CC
cord-018804-wj35q88f	119	9	chicken	chicken	NN
cord-018804-wj35q88f	119	10	pox	pox	NN
cord-018804-wj35q88f	119	11	,	,	,
cord-018804-wj35q88f	119	12	can	can	MD
cord-018804-wj35q88f	119	13	only	only	RB
cord-018804-wj35q88f	119	14	infect	infect	VB
cord-018804-wj35q88f	119	15	once	once	RB
cord-018804-wj35q88f	119	16	,	,	,
cord-018804-wj35q88f	119	17	because	because	IN
cord-018804-wj35q88f	119	18	their	-PRON-	PRP$
cord-018804-wj35q88f	119	19	antigenic	antigenic	JJ
cord-018804-wj35q88f	119	20	determinants	determinant	NNS
cord-018804-wj35q88f	119	21	have	have	VBP
cord-018804-wj35q88f	119	22	very	very	RB
cord-018804-wj35q88f	119	23	slow	slow	JJ
cord-018804-wj35q88f	119	24	evolution	evolution	NN
cord-018804-wj35q88f	119	25	rate	rate	NN
cord-018804-wj35q88f	119	26	and	and	CC
cord-018804-wj35q88f	119	27	the	the	DT
cord-018804-wj35q88f	119	28	immunological	immunological	JJ
cord-018804-wj35q88f	119	29	response	response	NN
cord-018804-wj35q88f	119	30	of	of	IN
cord-018804-wj35q88f	119	31	the	the	DT
cord-018804-wj35q88f	119	32	memory	memory	NN
cord-018804-wj35q88f	119	33	cells	cell	NNS
cord-018804-wj35q88f	119	34	continues	continue	VBZ
cord-018804-wj35q88f	119	35	being	be	VBG
cord-018804-wj35q88f	119	36	effective	effective	JJ
cord-018804-wj35q88f	119	37	along	along	IN
cord-018804-wj35q88f	119	38	the	the	DT
cord-018804-wj35q88f	119	39	whole	whole	JJ
cord-018804-wj35q88f	119	40	life	life	NN
cord-018804-wj35q88f	119	41	of	of	IN
cord-018804-wj35q88f	119	42	the	the	DT
cord-018804-wj35q88f	119	43	individual	individual	NN
cord-018804-wj35q88f	119	44	.	.	.
cord-018804-wj35q88f	120	1	In	in	IN
cord-018804-wj35q88f	120	2	contrast	contrast	NN
cord-018804-wj35q88f	120	3	,	,	,
cord-018804-wj35q88f	120	4	there	there	EX
cord-018804-wj35q88f	120	5	are	be	VBP
cord-018804-wj35q88f	120	6	other	other	JJ
cord-018804-wj35q88f	120	7	viruses	virus	NNS
cord-018804-wj35q88f	120	8	,	,	,
cord-018804-wj35q88f	120	9	influenza	influenza	NN
cord-018804-wj35q88f	120	10	being	be	VBG
cord-018804-wj35q88f	120	11	the	the	DT
cord-018804-wj35q88f	120	12	paradigmatic	paradigmatic	JJ
cord-018804-wj35q88f	120	13	example	example	NN
cord-018804-wj35q88f	121	1	,	,	,
cord-018804-wj35q88f	121	2	that	that	DT
cord-018804-wj35q88f	121	3	can	can	MD
cord-018804-wj35q88f	121	4	infect	infect	VB
cord-018804-wj35q88f	121	5	the	the	DT
cord-018804-wj35q88f	121	6	same	same	JJ
cord-018804-wj35q88f	121	7	organism	organism	NN
cord-018804-wj35q88f	121	8	repeated	repeat	VBD
cord-018804-wj35q88f	121	9	times	time	NNS
cord-018804-wj35q88f	121	10	.	.	.
cord-018804-wj35q88f	122	1	Most	Most	JJS
cord-018804-wj35q88f	122	2	experimental	experimental	JJ
cord-018804-wj35q88f	122	3	evidence	evidence	NN
cord-018804-wj35q88f	122	4	leads	lead	VBZ
cord-018804-wj35q88f	122	5	to	to	IN
cord-018804-wj35q88f	122	6	the	the	DT
cord-018804-wj35q88f	122	7	conclusion	conclusion	NN
cord-018804-wj35q88f	122	8	that	that	IN
cord-018804-wj35q88f	122	9	the	the	DT
cord-018804-wj35q88f	122	10	tolerance	tolerance	NN
cord-018804-wj35q88f	122	11	of	of	IN
cord-018804-wj35q88f	122	12	a	a	DT
cord-018804-wj35q88f	122	13	virus	virus	NN
cord-018804-wj35q88f	122	14	to	to	TO
cord-018804-wj35q88f	122	15	accept	accept	VB
cord-018804-wj35q88f	122	16	immune	immune	JJ
cord-018804-wj35q88f	122	17	-	-	HYPH
cord-018804-wj35q88f	122	18	escape	escape	NN
cord-018804-wj35q88f	122	19	mutations	mutation	NNS
cord-018804-wj35q88f	122	20	is	be	VBZ
cord-018804-wj35q88f	122	21	limited	limit	VBN
cord-018804-wj35q88f	122	22	by	by	IN
cord-018804-wj35q88f	122	23	the	the	DT
cord-018804-wj35q88f	122	24	restriction	restriction	NN
cord-018804-wj35q88f	122	25	of	of	IN
cord-018804-wj35q88f	122	26	conserving	conserve	VBG
cord-018804-wj35q88f	122	27	the	the	DT
cord-018804-wj35q88f	122	28	cell	cell	NN
cord-018804-wj35q88f	122	29	tropism	tropism	NN
cord-018804-wj35q88f	122	30	[	[	-LRB-
cord-018804-wj35q88f	122	31	26	26	CD
cord-018804-wj35q88f	122	32	]	]	-RRB-
cord-018804-wj35q88f	122	33	.	.	.
cord-018804-wj35q88f	123	1	Modifications	modification	NNS
cord-018804-wj35q88f	123	2	in	in	IN
cord-018804-wj35q88f	123	3	the	the	DT
cord-018804-wj35q88f	123	4	capside	capside	JJ
cord-018804-wj35q88f	123	5	antigen	antigen	NN
cord-018804-wj35q88f	123	6	domains	domain	NNS
cord-018804-wj35q88f	123	7	of	of	IN
cord-018804-wj35q88f	123	8	measles	measle	NNS
cord-018804-wj35q88f	123	9	virus	virus	NN
cord-018804-wj35q88f	123	10	seem	seem	VBP
cord-018804-wj35q88f	123	11	to	to	TO
cord-018804-wj35q88f	123	12	have	have	VB
cord-018804-wj35q88f	123	13	very	very	RB
cord-018804-wj35q88f	123	14	deleterious	deleterious	JJ
cord-018804-wj35q88f	123	15	effects	effect	NNS
cord-018804-wj35q88f	123	16	,	,	,
cord-018804-wj35q88f	123	17	possibly	possibly	RB
cord-018804-wj35q88f	123	18	because	because	IN
cord-018804-wj35q88f	123	19	they	-PRON-	PRP
cord-018804-wj35q88f	123	20	affect	affect	VBP
cord-018804-wj35q88f	123	21	the	the	DT
cord-018804-wj35q88f	123	22	recognition	recognition	NN
cord-018804-wj35q88f	123	23	of	of	IN
cord-018804-wj35q88f	123	24	the	the	DT
cord-018804-wj35q88f	123	25	cellular	cellular	JJ
cord-018804-wj35q88f	123	26	receptors	receptor	NNS
cord-018804-wj35q88f	123	27	.	.	.
cord-018804-wj35q88f	124	1	In	in	IN
cord-018804-wj35q88f	124	2	contrast	contrast	NN
cord-018804-wj35q88f	124	3	,	,	,
cord-018804-wj35q88f	124	4	influenza	influenza	NN
cord-018804-wj35q88f	124	5	can	can	MD
cord-018804-wj35q88f	124	6	experience	experience	VB
cord-018804-wj35q88f	124	7	a	a	DT
cord-018804-wj35q88f	124	8	continuous	continuous	JJ
cord-018804-wj35q88f	124	9	change	change	NN
cord-018804-wj35q88f	124	10	in	in	IN
cord-018804-wj35q88f	124	11	the	the	DT
cord-018804-wj35q88f	124	12	antigenic	antigenic	JJ
cord-018804-wj35q88f	124	13	properties	property	NNS
cord-018804-wj35q88f	124	14	of	of	IN
cord-018804-wj35q88f	124	15	the	the	DT
cord-018804-wj35q88f	124	16	two	two	CD
cord-018804-wj35q88f	124	17	main	main	JJ
cord-018804-wj35q88f	124	18	surface	surface	NN
cord-018804-wj35q88f	124	19	proteins	protein	NNS
cord-018804-wj35q88f	124	20	involved	involve	VBN
cord-018804-wj35q88f	124	21	in	in	IN
cord-018804-wj35q88f	124	22	the	the	DT
cord-018804-wj35q88f	124	23	entry	entry	NN
cord-018804-wj35q88f	124	24	of	of	IN
cord-018804-wj35q88f	124	25	the	the	DT
cord-018804-wj35q88f	124	26	virus	virus	NN
cord-018804-wj35q88f	124	27	inside	inside	IN
cord-018804-wj35q88f	124	28	the	the	DT
cord-018804-wj35q88f	124	29	cell	cell	NN
cord-018804-wj35q88f	124	30	,	,	,
cord-018804-wj35q88f	124	31	the	the	DT
cord-018804-wj35q88f	124	32	hemagglutinin	hemagglutinin	NN
cord-018804-wj35q88f	124	33	and	and	CC
cord-018804-wj35q88f	124	34	the	the	DT
cord-018804-wj35q88f	124	35	neuraminidase	neuraminidase	NN
cord-018804-wj35q88f	124	36	.	.	.
cord-018804-wj35q88f	125	1	The	the	DT
cord-018804-wj35q88f	125	2	evolution	evolution	NN
cord-018804-wj35q88f	125	3	of	of	IN
cord-018804-wj35q88f	125	4	the	the	DT
cord-018804-wj35q88f	125	5	virus	virus	NN
cord-018804-wj35q88f	125	6	seems	seem	VBZ
cord-018804-wj35q88f	125	7	to	to	TO
cord-018804-wj35q88f	125	8	be	be	VB
cord-018804-wj35q88f	125	9	strongly	strongly	RB
cord-018804-wj35q88f	125	10	influenced	influence	VBN
cord-018804-wj35q88f	125	11	by	by	IN
cord-018804-wj35q88f	125	12	selection	selection	NN
cord-018804-wj35q88f	125	13	of	of	IN
cord-018804-wj35q88f	125	14	new	new	JJ
cord-018804-wj35q88f	125	15	antigenic	antigenic	JJ
cord-018804-wj35q88f	125	16	variants	variant	NNS
cord-018804-wj35q88f	125	17	to	to	TO
cord-018804-wj35q88f	125	18	escape	escape	VB
cord-018804-wj35q88f	125	19	the	the	DT
cord-018804-wj35q88f	125	20	immune	immune	JJ
cord-018804-wj35q88f	125	21	system	system	NN
cord-018804-wj35q88f	125	22	at	at	IN
cord-018804-wj35q88f	125	23	the	the	DT
cord-018804-wj35q88f	125	24	same	same	JJ
cord-018804-wj35q88f	125	25	time	time	NN
cord-018804-wj35q88f	125	26	that	that	WDT
cord-018804-wj35q88f	125	27	the	the	DT
cord-018804-wj35q88f	125	28	capacity	capacity	NN
cord-018804-wj35q88f	125	29	of	of	IN
cord-018804-wj35q88f	125	30	interaction	interaction	NN
cord-018804-wj35q88f	125	31	with	with	IN
cord-018804-wj35q88f	125	32	the	the	DT
cord-018804-wj35q88f	125	33	cellular	cellular	JJ
cord-018804-wj35q88f	125	34	receptor	receptor	NN
cord-018804-wj35q88f	125	35	is	be	VBZ
cord-018804-wj35q88f	125	36	preserved	preserve	VBN
cord-018804-wj35q88f	125	37	[	[	-LRB-
cord-018804-wj35q88f	125	38	15	15	CD
cord-018804-wj35q88f	125	39	]	]	-RRB-
cord-018804-wj35q88f	125	40	.	.	.
cord-018804-wj35q88f	126	1	In	in	IN
cord-018804-wj35q88f	126	2	the	the	DT
cord-018804-wj35q88f	126	3	case	case	NN
cord-018804-wj35q88f	126	4	of	of	IN
cord-018804-wj35q88f	126	5	the	the	DT
cord-018804-wj35q88f	126	6	hemagglutinin	hemagglutinin	NN
cord-018804-wj35q88f	126	7	gene	gene	NN
cord-018804-wj35q88f	126	8	,	,	,
cord-018804-wj35q88f	126	9	18	18	CD
cord-018804-wj35q88f	126	10	codon	codon	NN
cord-018804-wj35q88f	126	11	sites	site	NNS
cord-018804-wj35q88f	126	12	have	have	VBP
cord-018804-wj35q88f	126	13	been	be	VBN
cord-018804-wj35q88f	126	14	identified	identify	VBN
cord-018804-wj35q88f	126	15	in	in	IN
cord-018804-wj35q88f	126	16	which	which	WDT
cord-018804-wj35q88f	126	17	non	non	JJ
cord-018804-wj35q88f	126	18	-	-	JJ
cord-018804-wj35q88f	126	19	synonymous	synonymous	JJ
cord-018804-wj35q88f	126	20	nucleotide	nucleotide	JJ
cord-018804-wj35q88f	126	21	substitutions	substitution	NNS
cord-018804-wj35q88f	126	22	are	be	VBP
cord-018804-wj35q88f	126	23	much	much	RB
cord-018804-wj35q88f	126	24	more	more	RBR
cord-018804-wj35q88f	126	25	frequent	frequent	JJ
cord-018804-wj35q88f	126	26	than	than	IN
cord-018804-wj35q88f	126	27	synonymous	synonymous	JJ
cord-018804-wj35q88f	126	28	[	[	-LRB-
cord-018804-wj35q88f	126	29	27	27	CD
cord-018804-wj35q88f	126	30	,	,	,
cord-018804-wj35q88f	126	31	28	28	CD
cord-018804-wj35q88f	126	32	]	]	-RRB-
cord-018804-wj35q88f	126	33	.	.	.
cord-018804-wj35q88f	127	1	The	the	DT
cord-018804-wj35q88f	127	2	remaining	remain	VBG
cord-018804-wj35q88f	127	3	sites	site	NNS
cord-018804-wj35q88f	127	4	show	show	VBP
cord-018804-wj35q88f	127	5	the	the	DT
cord-018804-wj35q88f	127	6	more	more	RBR
cord-018804-wj35q88f	127	7	common	common	JJ
cord-018804-wj35q88f	127	8	pattern	pattern	NN
cord-018804-wj35q88f	127	9	of	of	IN
cord-018804-wj35q88f	127	10	synonymous	synonymous	JJ
cord-018804-wj35q88f	127	11	substitutions	substitution	NNS
cord-018804-wj35q88f	127	12	,	,	,
cord-018804-wj35q88f	127	13	indicating	indicate	VBG
cord-018804-wj35q88f	127	14	that	that	IN
cord-018804-wj35q88f	127	15	possibly	possibly	RB
cord-018804-wj35q88f	127	16	they	-PRON-	PRP
cord-018804-wj35q88f	127	17	are	be	VBP
cord-018804-wj35q88f	127	18	subjected	subject	VBN
cord-018804-wj35q88f	127	19	to	to	IN
cord-018804-wj35q88f	127	20	stronger	strong	JJR
cord-018804-wj35q88f	127	21	evolutionary	evolutionary	JJ
cord-018804-wj35q88f	127	22	constraints	constraint	NNS
cord-018804-wj35q88f	127	23	.	.	.
cord-018804-wj35q88f	128	1	3	3	LS
cord-018804-wj35q88f	128	2	.	.	.
cord-018804-wj35q88f	129	1	Change	change	NN
cord-018804-wj35q88f	129	2	of	of	IN
cord-018804-wj35q88f	129	3	tropism	tropism	NN
cord-018804-wj35q88f	129	4	.	.	.
cord-018804-wj35q88f	130	1	Many	many	JJ
cord-018804-wj35q88f	130	2	viruses	virus	NNS
cord-018804-wj35q88f	130	3	are	be	VBP
cord-018804-wj35q88f	130	4	maintained	maintain	VBN
cord-018804-wj35q88f	130	5	in	in	IN
cord-018804-wj35q88f	130	6	nature	nature	NN
cord-018804-wj35q88f	130	7	in	in	IN
cord-018804-wj35q88f	130	8	animal	animal	NN
cord-018804-wj35q88f	130	9	reservoirs	reservoir	NNS
cord-018804-wj35q88f	130	10	that	that	WDT
cord-018804-wj35q88f	130	11	do	do	VBP
cord-018804-wj35q88f	130	12	not	not	RB
cord-018804-wj35q88f	130	13	manifest	manifest	VB
cord-018804-wj35q88f	130	14	symptoms	symptom	NNS
cord-018804-wj35q88f	130	15	of	of	IN
cord-018804-wj35q88f	130	16	disease	disease	NN
cord-018804-wj35q88f	130	17	.	.	.
cord-018804-wj35q88f	131	1	This	this	DT
cord-018804-wj35q88f	131	2	probably	probably	RB
cord-018804-wj35q88f	131	3	occurs	occur	VBZ
cord-018804-wj35q88f	131	4	because	because	IN
cord-018804-wj35q88f	131	5	the	the	DT
cord-018804-wj35q88f	131	6	relation	relation	NN
cord-018804-wj35q88f	131	7	virus	virus	NN
cord-018804-wj35q88f	131	8	-	-	HYPH
cord-018804-wj35q88f	131	9	host	host	NN
cord-018804-wj35q88f	131	10	is	be	VBZ
cord-018804-wj35q88f	131	11	very	very	RB
cord-018804-wj35q88f	131	12	old	old	JJ
cord-018804-wj35q88f	131	13	(	(	-LRB-
cord-018804-wj35q88f	131	14	hundreds	hundred	NNS
cord-018804-wj35q88f	131	15	or	or	CC
cord-018804-wj35q88f	131	16	thousands	thousand	NNS
cord-018804-wj35q88f	131	17	of	of	IN
cord-018804-wj35q88f	131	18	years	year	NNS
cord-018804-wj35q88f	131	19	)	)	-RRB-
cord-018804-wj35q88f	131	20	and	and	CC
cord-018804-wj35q88f	131	21	both	both	DT
cord-018804-wj35q88f	131	22	species	specie	NNS
cord-018804-wj35q88f	131	23	have	have	VBP
cord-018804-wj35q88f	131	24	had	have	VBN
cord-018804-wj35q88f	131	25	enough	enough	JJ
cord-018804-wj35q88f	131	26	time	time	NN
cord-018804-wj35q88f	131	27	to	to	TO
cord-018804-wj35q88f	131	28	co	co	VB
cord-018804-wj35q88f	131	29	-	-	VB
cord-018804-wj35q88f	131	30	evolve	evolve	VB
cord-018804-wj35q88f	131	31	,	,	,
cord-018804-wj35q88f	131	32	meaning	mean	VBG
cord-018804-wj35q88f	131	33	that	that	IN
cord-018804-wj35q88f	131	34	the	the	DT
cord-018804-wj35q88f	131	35	virus	virus	NN
cord-018804-wj35q88f	131	36	has	have	VBZ
cord-018804-wj35q88f	131	37	attenuated	attenuate	VBN
cord-018804-wj35q88f	131	38	its	-PRON-	PRP$
cord-018804-wj35q88f	131	39	virulence	virulence	NN
cord-018804-wj35q88f	131	40	and	and	CC
cord-018804-wj35q88f	131	41	the	the	DT
cord-018804-wj35q88f	131	42	host	host	NN
cord-018804-wj35q88f	131	43	also	also	RB
cord-018804-wj35q88f	131	44	has	have	VBZ
cord-018804-wj35q88f	131	45	acquired	acquire	VBN
cord-018804-wj35q88f	131	46	some	some	DT
cord-018804-wj35q88f	131	47	properties	property	NNS
cord-018804-wj35q88f	131	48	that	that	WDT
cord-018804-wj35q88f	131	49	permit	permit	VBP
cord-018804-wj35q88f	131	50	coexistence	coexistence	NN
cord-018804-wj35q88f	131	51	with	with	IN
cord-018804-wj35q88f	131	52	the	the	DT
cord-018804-wj35q88f	131	53	pathogen	pathogen	NN
cord-018804-wj35q88f	131	54	.	.	.
cord-018804-wj35q88f	132	1	The	the	DT
cord-018804-wj35q88f	132	2	long	long	JJ
cord-018804-wj35q88f	132	3	time	time	NN
cord-018804-wj35q88f	132	4	of	of	IN
cord-018804-wj35q88f	132	5	evolution	evolution	NN
cord-018804-wj35q88f	132	6	in	in	IN
cord-018804-wj35q88f	132	7	the	the	DT
cord-018804-wj35q88f	132	8	same	same	JJ
cord-018804-wj35q88f	132	9	host	host	NN
cord-018804-wj35q88f	132	10	has	have	VBZ
cord-018804-wj35q88f	132	11	permitted	permit	VBN
cord-018804-wj35q88f	132	12	to	to	IN
cord-018804-wj35q88f	132	13	these	these	DT
cord-018804-wj35q88f	132	14	viruses	virus	NNS
cord-018804-wj35q88f	132	15	to	to	TO
cord-018804-wj35q88f	132	16	be	be	VB
cord-018804-wj35q88f	132	17	close	close	JJ
cord-018804-wj35q88f	132	18	to	to	IN
cord-018804-wj35q88f	132	19	the	the	DT
cord-018804-wj35q88f	132	20	equilibrium	equilibrium	NN
cord-018804-wj35q88f	132	21	between	between	IN
cord-018804-wj35q88f	132	22	mutation	mutation	NN
cord-018804-wj35q88f	132	23	and	and	CC
cord-018804-wj35q88f	132	24	selection	selection	NN
cord-018804-wj35q88f	132	25	processes	process	NNS
cord-018804-wj35q88f	132	26	and	and	CC
cord-018804-wj35q88f	132	27	to	to	TO
cord-018804-wj35q88f	132	28	maintain	maintain	VB
cord-018804-wj35q88f	132	29	a	a	DT
cord-018804-wj35q88f	132	30	high	high	JJ
cord-018804-wj35q88f	132	31	stability	stability	NN
cord-018804-wj35q88f	132	32	in	in	IN
cord-018804-wj35q88f	132	33	the	the	DT
cord-018804-wj35q88f	132	34	consensus	consensus	NN
cord-018804-wj35q88f	132	35	sequence	sequence	NN
cord-018804-wj35q88f	132	36	.	.	.
cord-018804-wj35q88f	133	1	Occasionally	occasionally	RB
cord-018804-wj35q88f	133	2	,	,	,
cord-018804-wj35q88f	133	3	a	a	DT
cord-018804-wj35q88f	133	4	virus	virus	NN
cord-018804-wj35q88f	133	5	well	well	RB
cord-018804-wj35q88f	133	6	-	-	HYPH
cord-018804-wj35q88f	133	7	adapted	adapt	VBN
cord-018804-wj35q88f	133	8	for	for	IN
cord-018804-wj35q88f	133	9	replication	replication	NN
cord-018804-wj35q88f	133	10	in	in	IN
cord-018804-wj35q88f	133	11	a	a	DT
cord-018804-wj35q88f	133	12	particular	particular	JJ
cord-018804-wj35q88f	133	13	host	host	NN
cord-018804-wj35q88f	133	14	can	can	MD
cord-018804-wj35q88f	133	15	cross	cross	VB
cord-018804-wj35q88f	133	16	the	the	DT
cord-018804-wj35q88f	133	17	species	species	NN
cord-018804-wj35q88f	133	18	boundaries	boundary	NNS
cord-018804-wj35q88f	133	19	and	and	CC
cord-018804-wj35q88f	133	20	infect	infect	VB
cord-018804-wj35q88f	133	21	a	a	DT
cord-018804-wj35q88f	133	22	new	new	JJ
cord-018804-wj35q88f	133	23	host	host	NN
cord-018804-wj35q88f	133	24	.	.	.
cord-018804-wj35q88f	134	1	This	this	DT
cord-018804-wj35q88f	134	2	can	can	MD
cord-018804-wj35q88f	134	3	be	be	VB
cord-018804-wj35q88f	134	4	facilitated	facilitate	VBN
cord-018804-wj35q88f	134	5	by	by	IN
cord-018804-wj35q88f	134	6	genetic	genetic	JJ
cord-018804-wj35q88f	134	7	changes	change	NNS
cord-018804-wj35q88f	134	8	in	in	IN
cord-018804-wj35q88f	134	9	the	the	DT
cord-018804-wj35q88f	134	10	virus	virus	NN
cord-018804-wj35q88f	134	11	and/or	and/or	CC
cord-018804-wj35q88f	134	12	by	by	IN
cord-018804-wj35q88f	134	13	ecological	ecological	JJ
cord-018804-wj35q88f	134	14	factors	factor	NNS
cord-018804-wj35q88f	134	15	that	that	WDT
cord-018804-wj35q88f	134	16	involve	involve	VBP
cord-018804-wj35q88f	134	17	alterations	alteration	NNS
cord-018804-wj35q88f	134	18	in	in	IN
cord-018804-wj35q88f	134	19	the	the	DT
cord-018804-wj35q88f	134	20	relationships	relationship	NNS
cord-018804-wj35q88f	134	21	established	establish	VBN
cord-018804-wj35q88f	134	22	among	among	IN
cord-018804-wj35q88f	134	23	different	different	JJ
cord-018804-wj35q88f	134	24	species	specie	NNS
cord-018804-wj35q88f	134	25	in	in	IN
cord-018804-wj35q88f	134	26	nature	nature	NN
cord-018804-wj35q88f	134	27	[	[	-LRB-
cord-018804-wj35q88f	134	28	29	29	CD
cord-018804-wj35q88f	134	29	,	,	,
cord-018804-wj35q88f	134	30	30	30	CD
cord-018804-wj35q88f	134	31	]	]	-RRB-
cord-018804-wj35q88f	134	32	.	.	.
cord-018804-wj35q88f	135	1	The	the	DT
cord-018804-wj35q88f	135	2	infection	infection	NN
cord-018804-wj35q88f	135	3	of	of	IN
cord-018804-wj35q88f	135	4	a	a	DT
cord-018804-wj35q88f	135	5	new	new	JJ
cord-018804-wj35q88f	135	6	host	host	NN
cord-018804-wj35q88f	135	7	constitutes	constitute	VBZ
cord-018804-wj35q88f	135	8	a	a	DT
cord-018804-wj35q88f	135	9	sudden	sudden	JJ
cord-018804-wj35q88f	135	10	change	change	NN
cord-018804-wj35q88f	135	11	in	in	IN
cord-018804-wj35q88f	135	12	the	the	DT
cord-018804-wj35q88f	135	13	environment	environment	NN
cord-018804-wj35q88f	135	14	in	in	IN
cord-018804-wj35q88f	135	15	which	which	WDT
cord-018804-wj35q88f	135	16	viral	viral	JJ
cord-018804-wj35q88f	135	17	replication	replication	NN
cord-018804-wj35q88f	135	18	takes	take	VBZ
cord-018804-wj35q88f	135	19	place	place	NN
cord-018804-wj35q88f	135	20	,	,	,
cord-018804-wj35q88f	135	21	usually	usually	RB
cord-018804-wj35q88f	135	22	with	with	IN
cord-018804-wj35q88f	135	23	the	the	DT
cord-018804-wj35q88f	135	24	consequence	consequence	NN
cord-018804-wj35q88f	135	25	of	of	IN
cord-018804-wj35q88f	135	26	a	a	DT
cord-018804-wj35q88f	135	27	drastic	drastic	JJ
cord-018804-wj35q88f	135	28	decrease	decrease	NN
cord-018804-wj35q88f	135	29	in	in	IN
cord-018804-wj35q88f	135	30	the	the	DT
cord-018804-wj35q88f	135	31	average	average	JJ
cord-018804-wj35q88f	135	32	fitness	fitness	NN
cord-018804-wj35q88f	135	33	of	of	IN
cord-018804-wj35q88f	135	34	the	the	DT
cord-018804-wj35q88f	135	35	virus	virus	NN
cord-018804-wj35q88f	135	36	population	population	NN
cord-018804-wj35q88f	135	37	,	,	,
cord-018804-wj35q88f	135	38	which	which	WDT
cord-018804-wj35q88f	135	39	prevents	prevent	VBZ
cord-018804-wj35q88f	135	40	further	further	JJ
cord-018804-wj35q88f	135	41	transmission	transmission	NN
cord-018804-wj35q88f	135	42	.	.	.
cord-018804-wj35q88f	136	1	The	the	DT
cord-018804-wj35q88f	136	2	success	success	NN
cord-018804-wj35q88f	136	3	of	of	IN
cord-018804-wj35q88f	136	4	a	a	DT
cord-018804-wj35q88f	136	5	virus	virus	NN
cord-018804-wj35q88f	136	6	to	to	TO
cord-018804-wj35q88f	136	7	establish	establish	VB
cord-018804-wj35q88f	136	8	as	as	IN
cord-018804-wj35q88f	136	9	a	a	DT
cord-018804-wj35q88f	136	10	new	new	JJ
cord-018804-wj35q88f	136	11	infectious	infectious	JJ
cord-018804-wj35q88f	136	12	agent	agent	NN
cord-018804-wj35q88f	136	13	in	in	IN
cord-018804-wj35q88f	136	14	the	the	DT
cord-018804-wj35q88f	136	15	new	new	JJ
cord-018804-wj35q88f	136	16	host	host	NN
cord-018804-wj35q88f	136	17	relies	rely	VBZ
cord-018804-wj35q88f	136	18	largely	largely	RB
cord-018804-wj35q88f	136	19	on	on	IN
cord-018804-wj35q88f	136	20	two	two	CD
cord-018804-wj35q88f	136	21	features	feature	NNS
cord-018804-wj35q88f	136	22	(	(	-LRB-
cord-018804-wj35q88f	136	23	a	a	LS
cord-018804-wj35q88f	136	24	)	)	-RRB-
cord-018804-wj35q88f	136	25	its	-PRON-	PRP$
cord-018804-wj35q88f	136	26	ability	ability	NN
cord-018804-wj35q88f	136	27	to	to	TO
cord-018804-wj35q88f	136	28	interact	interact	VB
cord-018804-wj35q88f	136	29	with	with	IN
cord-018804-wj35q88f	136	30	a	a	DT
cord-018804-wj35q88f	136	31	cellular	cellular	JJ
cord-018804-wj35q88f	136	32	receptor	receptor	NN
cord-018804-wj35q88f	136	33	that	that	WDT
cord-018804-wj35q88f	136	34	permits	permit	VBZ
cord-018804-wj35q88f	136	35	the	the	DT
cord-018804-wj35q88f	136	36	entry	entry	NN
cord-018804-wj35q88f	136	37	inside	inside	IN
cord-018804-wj35q88f	136	38	the	the	DT
cord-018804-wj35q88f	136	39	cells	cell	NNS
cord-018804-wj35q88f	136	40	and	and	CC
cord-018804-wj35q88f	136	41	(	(	-LRB-
cord-018804-wj35q88f	136	42	b	b	LS
cord-018804-wj35q88f	136	43	)	)	-RRB-
cord-018804-wj35q88f	136	44	the	the	DT
cord-018804-wj35q88f	136	45	acquisition	acquisition	NN
cord-018804-wj35q88f	136	46	and	and	CC
cord-018804-wj35q88f	136	47	fixation	fixation	NN
cord-018804-wj35q88f	136	48	of	of	IN
cord-018804-wj35q88f	136	49	mutations	mutation	NNS
cord-018804-wj35q88f	136	50	that	that	WDT
cord-018804-wj35q88f	136	51	allow	allow	VBP
cord-018804-wj35q88f	136	52	efficient	efficient	JJ
cord-018804-wj35q88f	136	53	replication	replication	NN
cord-018804-wj35q88f	136	54	and	and	CC
cord-018804-wj35q88f	136	55	capacity	capacity	NN
cord-018804-wj35q88f	136	56	of	of	IN
cord-018804-wj35q88f	136	57	transmission	transmission	NN
cord-018804-wj35q88f	136	58	between	between	IN
cord-018804-wj35q88f	136	59	organisms	organism	NNS
cord-018804-wj35q88f	136	60	.	.	.
cord-018804-wj35q88f	137	1	Most	Most	JJS
cord-018804-wj35q88f	137	2	recent	recent	JJ
cord-018804-wj35q88f	137	3	virus	virus	NN
cord-018804-wj35q88f	137	4	emergences	emergence	NNS
cord-018804-wj35q88f	137	5	in	in	IN
cord-018804-wj35q88f	137	6	humans	human	NNS
cord-018804-wj35q88f	137	7	include	include	VBP
cord-018804-wj35q88f	137	8	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	137	9	,	,	,
cord-018804-wj35q88f	137	10	whose	whose	WP$
cord-018804-wj35q88f	137	11	closest	close	JJS
cord-018804-wj35q88f	137	12	animal	animal	NN
cord-018804-wj35q88f	137	13	ancestor	ancestor	NN
cord-018804-wj35q88f	137	14	seems	seem	VBZ
cord-018804-wj35q88f	137	15	to	to	TO
cord-018804-wj35q88f	137	16	be	be	VB
cord-018804-wj35q88f	137	17	the	the	DT
cord-018804-wj35q88f	137	18	simian	simian	JJ
cord-018804-wj35q88f	137	19	immunodeficiency	immunodeficiency	NN
cord-018804-wj35q88f	137	20	virus	virus	NN
cord-018804-wj35q88f	137	21	found	find	VBN
cord-018804-wj35q88f	137	22	in	in	IN
cord-018804-wj35q88f	137	23	a	a	DT
cord-018804-wj35q88f	137	24	particular	particular	JJ
cord-018804-wj35q88f	137	25	species	species	NN
cord-018804-wj35q88f	137	26	of	of	IN
cord-018804-wj35q88f	137	27	chimpanzees	chimpanzee	NNS
cord-018804-wj35q88f	138	1	(	(	-LRB-
cord-018804-wj35q88f	138	2	SIVcpz	SIVcpz	NNP
cord-018804-wj35q88f	138	3	)	)	-RRB-
cord-018804-wj35q88f	139	1	[	[	-LRB-
cord-018804-wj35q88f	139	2	31	31	CD
cord-018804-wj35q88f	139	3	]	]	-RRB-
cord-018804-wj35q88f	139	4	,	,	.
cord-018804-wj35q88f	140	1	the	the	DT
cord-018804-wj35q88f	140	2	coronavirus	coronavirus	NN
cord-018804-wj35q88f	140	3	causing	cause	VBG
cord-018804-wj35q88f	140	4	SARS	SARS	NNP
cord-018804-wj35q88f	140	5	(	(	-LRB-
cord-018804-wj35q88f	140	6	severe	severe	JJ
cord-018804-wj35q88f	140	7	acute	acute	JJ
cord-018804-wj35q88f	140	8	respiratory	respiratory	JJ
cord-018804-wj35q88f	140	9	syndrome	syndrome	NN
cord-018804-wj35q88f	140	10	)	)	-RRB-
cord-018804-wj35q88f	140	11	[	[	-LRB-
cord-018804-wj35q88f	140	12	32	32	CD
cord-018804-wj35q88f	140	13	]	]	-RRB-
cord-018804-wj35q88f	140	14	and	and	CC
cord-018804-wj35q88f	140	15	the	the	DT
cord-018804-wj35q88f	140	16	influenza	influenza	NN
cord-018804-wj35q88f	140	17	virus	virus	NN
cord-018804-wj35q88f	140	18	H5N1	H5N1	NNP
cord-018804-wj35q88f	140	19	,	,	,
cord-018804-wj35q88f	140	20	an	an	DT
cord-018804-wj35q88f	140	21	avian	avian	JJ
cord-018804-wj35q88f	140	22	virus	virus	NN
cord-018804-wj35q88f	140	23	strain	strain	NN
cord-018804-wj35q88f	140	24	that	that	WDT
cord-018804-wj35q88f	140	25	can	can	MD
cord-018804-wj35q88f	140	26	infect	infect	VB
cord-018804-wj35q88f	140	27	directly	directly	RB
cord-018804-wj35q88f	140	28	humans	human	NNS
cord-018804-wj35q88f	140	29	without	without	IN
cord-018804-wj35q88f	140	30	further	further	JJ
cord-018804-wj35q88f	140	31	human	human	NN
cord-018804-wj35q88f	140	32	-	-	HYPH
cord-018804-wj35q88f	140	33	to	to	IN
cord-018804-wj35q88f	140	34	-	-	HYPH
cord-018804-wj35q88f	140	35	human	human	JJ
cord-018804-wj35q88f	140	36	transmission	transmission	NN
cord-018804-wj35q88f	140	37	[	[	-LRB-
cord-018804-wj35q88f	140	38	33	33	CD
cord-018804-wj35q88f	140	39	]	]	-RRB-
cord-018804-wj35q88f	140	40	.	.	.
cord-018804-wj35q88f	141	1	Virus	virus	NN
cord-018804-wj35q88f	141	2	dynamics	dynamic	NNS
cord-018804-wj35q88f	141	3	in	in	IN
cord-018804-wj35q88f	141	4	nature	nature	NN
cord-018804-wj35q88f	141	5	can	can	MD
cord-018804-wj35q88f	141	6	not	not	RB
cord-018804-wj35q88f	141	7	be	be	VB
cord-018804-wj35q88f	141	8	separated	separate	VBN
cord-018804-wj35q88f	141	9	from	from	IN
cord-018804-wj35q88f	141	10	host	host	NN
cord-018804-wj35q88f	141	11	population	population	NN
cord-018804-wj35q88f	141	12	dynamics	dynamic	NNS
cord-018804-wj35q88f	141	13	,	,	,
cord-018804-wj35q88f	141	14	constituting	constitute	VBG
cord-018804-wj35q88f	141	15	two	two	CD
cord-018804-wj35q88f	141	16	processes	process	NNS
cord-018804-wj35q88f	141	17	in	in	IN
cord-018804-wj35q88f	141	18	continuous	continuous	JJ
cord-018804-wj35q88f	141	19	interaction	interaction	NN
cord-018804-wj35q88f	141	20	[	[	-LRB-
cord-018804-wj35q88f	141	21	25	25	CD
cord-018804-wj35q88f	141	22	,	,	,
cord-018804-wj35q88f	141	23	34	34	CD
cord-018804-wj35q88f	141	24	,	,	,
cord-018804-wj35q88f	141	25	35	35	CD
cord-018804-wj35q88f	141	26	]	]	-RRB-
cord-018804-wj35q88f	141	27	.	.	.
cord-018804-wj35q88f	142	1	Factors	factor	NNS
cord-018804-wj35q88f	142	2	such	such	JJ
cord-018804-wj35q88f	142	3	as	as	IN
cord-018804-wj35q88f	142	4	the	the	DT
cord-018804-wj35q88f	142	5	transmission	transmission	NN
cord-018804-wj35q88f	142	6	mode	mode	NN
cord-018804-wj35q88f	142	7	,	,	,
cord-018804-wj35q88f	142	8	the	the	DT
cord-018804-wj35q88f	142	9	basic	basic	JJ
cord-018804-wj35q88f	142	10	reproductive	reproductive	JJ
cord-018804-wj35q88f	142	11	number	number	NN
cord-018804-wj35q88f	142	12	(	(	-LRB-
cord-018804-wj35q88f	142	13	R	r	NN
cord-018804-wj35q88f	142	14	0	0	CD
cord-018804-wj35q88f	142	15	)	)	-RRB-
cord-018804-wj35q88f	142	16	,	,	,
cord-018804-wj35q88f	142	17	the	the	DT
cord-018804-wj35q88f	142	18	duration	duration	NN
cord-018804-wj35q88f	142	19	of	of	IN
cord-018804-wj35q88f	142	20	the	the	DT
cord-018804-wj35q88f	142	21	infectious	infectious	JJ
cord-018804-wj35q88f	142	22	period	period	NN
cord-018804-wj35q88f	142	23	,	,	,
cord-018804-wj35q88f	142	24	the	the	DT
cord-018804-wj35q88f	142	25	renewal	renewal	NN
cord-018804-wj35q88f	142	26	of	of	IN
cord-018804-wj35q88f	142	27	susceptible	susceptible	JJ
cord-018804-wj35q88f	142	28	hosts	host	NNS
cord-018804-wj35q88f	142	29	and	and	CC
cord-018804-wj35q88f	142	30	the	the	DT
cord-018804-wj35q88f	142	31	durability	durability	NN
cord-018804-wj35q88f	142	32	of	of	IN
cord-018804-wj35q88f	142	33	the	the	DT
cord-018804-wj35q88f	142	34	immune	immune	JJ
cord-018804-wj35q88f	142	35	response	response	NN
cord-018804-wj35q88f	142	36	contribute	contribute	VBP
cord-018804-wj35q88f	142	37	to	to	TO
cord-018804-wj35q88f	142	38	shape	shape	VB
cord-018804-wj35q88f	142	39	the	the	DT
cord-018804-wj35q88f	142	40	genetic	genetic	JJ
cord-018804-wj35q88f	142	41	heterogeneity	heterogeneity	NN
cord-018804-wj35q88f	142	42	of	of	IN
cord-018804-wj35q88f	142	43	viruses	virus	NNS
cord-018804-wj35q88f	142	44	and	and	CC
cord-018804-wj35q88f	142	45	the	the	DT
cord-018804-wj35q88f	142	46	quasi	quasi	JJ
cord-018804-wj35q88f	142	47	-	-	JJ
cord-018804-wj35q88f	142	48	species	species	JJ
cord-018804-wj35q88f	142	49	structure	structure	NN
cord-018804-wj35q88f	142	50	.	.	.
cord-018804-wj35q88f	143	1	They	-PRON-	PRP
cord-018804-wj35q88f	143	2	also	also	RB
cord-018804-wj35q88f	143	3	strongly	strongly	RB
cord-018804-wj35q88f	143	4	condition	condition	VBP
cord-018804-wj35q88f	143	5	the	the	DT
cord-018804-wj35q88f	143	6	evolution	evolution	NN
cord-018804-wj35q88f	143	7	of	of	IN
cord-018804-wj35q88f	143	8	the	the	DT
cord-018804-wj35q88f	143	9	pathogen	pathogen	NN
cord-018804-wj35q88f	143	10	along	along	IN
cord-018804-wj35q88f	143	11	the	the	DT
cord-018804-wj35q88f	143	12	time	time	NN
cord-018804-wj35q88f	143	13	,	,	,
cord-018804-wj35q88f	143	14	adding	add	VBG
cord-018804-wj35q88f	143	15	a	a	DT
cord-018804-wj35q88f	143	16	great	great	JJ
cord-018804-wj35q88f	143	17	complexity	complexity	NN
cord-018804-wj35q88f	143	18	to	to	IN
cord-018804-wj35q88f	143	19	the	the	DT
cord-018804-wj35q88f	143	20	epidemiological	epidemiological	JJ
cord-018804-wj35q88f	143	21	and	and	CC
cord-018804-wj35q88f	143	22	phylogenetic	phylogenetic	JJ
cord-018804-wj35q88f	143	23	studies	study	NNS
cord-018804-wj35q88f	143	24	on	on	IN
cord-018804-wj35q88f	143	25	RNA	RNA	NNP
cord-018804-wj35q88f	143	26	viruses	virus	NNS
cord-018804-wj35q88f	143	27	.	.	.
cord-018804-wj35q88f	144	1	An	an	DT
cord-018804-wj35q88f	144	2	important	important	JJ
cord-018804-wj35q88f	144	3	factor	factor	NN
cord-018804-wj35q88f	144	4	in	in	IN
cord-018804-wj35q88f	144	5	viral	viral	JJ
cord-018804-wj35q88f	144	6	evolution	evolution	NN
cord-018804-wj35q88f	144	7	that	that	WDT
cord-018804-wj35q88f	144	8	takes	take	VBZ
cord-018804-wj35q88f	144	9	place	place	NN
cord-018804-wj35q88f	144	10	at	at	IN
cord-018804-wj35q88f	144	11	the	the	DT
cord-018804-wj35q88f	144	12	inter	inter	JJ
cord-018804-wj35q88f	144	13	-	-	JJ
cord-018804-wj35q88f	144	14	host	host	JJ
cord-018804-wj35q88f	144	15	level	level	NN
cord-018804-wj35q88f	144	16	is	be	VBZ
cord-018804-wj35q88f	144	17	the	the	DT
cord-018804-wj35q88f	144	18	number	number	NN
cord-018804-wj35q88f	144	19	of	of	IN
cord-018804-wj35q88f	144	20	viral	viral	JJ
cord-018804-wj35q88f	144	21	particles	particle	NNS
cord-018804-wj35q88f	144	22	that	that	WDT
cord-018804-wj35q88f	144	23	are	be	VBP
cord-018804-wj35q88f	144	24	transmitted	transmit	VBN
cord-018804-wj35q88f	144	25	from	from	IN
cord-018804-wj35q88f	144	26	one	one	CD
cord-018804-wj35q88f	144	27	host	host	NN
cord-018804-wj35q88f	144	28	to	to	IN
cord-018804-wj35q88f	144	29	the	the	DT
cord-018804-wj35q88f	144	30	other	other	JJ
cord-018804-wj35q88f	144	31	[	[	-LRB-
cord-018804-wj35q88f	144	32	20	20	CD
cord-018804-wj35q88f	144	33	]	]	-RRB-
cord-018804-wj35q88f	144	34	.	.	.
cord-018804-wj35q88f	145	1	When	when	WRB
cord-018804-wj35q88f	145	2	this	this	DT
cord-018804-wj35q88f	145	3	number	number	NN
cord-018804-wj35q88f	145	4	is	be	VBZ
cord-018804-wj35q88f	145	5	very	very	RB
cord-018804-wj35q88f	145	6	small	small	JJ
cord-018804-wj35q88f	145	7	,	,	,
cord-018804-wj35q88f	145	8	a	a	DT
cord-018804-wj35q88f	145	9	population	population	NN
cord-018804-wj35q88f	145	10	bottleneck	bottleneck	NN
cord-018804-wj35q88f	145	11	takes	take	VBZ
cord-018804-wj35q88f	145	12	place	place	NN
cord-018804-wj35q88f	145	13	.	.	.
cord-018804-wj35q88f	146	1	Then	then	RB
cord-018804-wj35q88f	146	2	,	,	,
cord-018804-wj35q88f	146	3	only	only	RB
cord-018804-wj35q88f	146	4	one	one	CD
cord-018804-wj35q88f	146	5	or	or	CC
cord-018804-wj35q88f	146	6	few	few	JJ
cord-018804-wj35q88f	146	7	individuals	individual	NNS
cord-018804-wj35q88f	146	8	originate	originate	VBP
cord-018804-wj35q88f	146	9	a	a	DT
cord-018804-wj35q88f	146	10	new	new	JJ
cord-018804-wj35q88f	146	11	population	population	NN
cord-018804-wj35q88f	146	12	,	,	,
cord-018804-wj35q88f	146	13	resulting	result	VBG
cord-018804-wj35q88f	146	14	in	in	IN
cord-018804-wj35q88f	146	15	a	a	DT
cord-018804-wj35q88f	146	16	strong	strong	JJ
cord-018804-wj35q88f	146	17	reduction	reduction	NN
cord-018804-wj35q88f	146	18	in	in	IN
cord-018804-wj35q88f	146	19	the	the	DT
cord-018804-wj35q88f	146	20	genetic	genetic	JJ
cord-018804-wj35q88f	146	21	diversity	diversity	NN
cord-018804-wj35q88f	146	22	.	.	.
cord-018804-wj35q88f	147	1	The	the	DT
cord-018804-wj35q88f	147	2	consequence	consequence	NN
cord-018804-wj35q88f	147	3	is	be	VBZ
cord-018804-wj35q88f	147	4	that	that	IN
cord-018804-wj35q88f	147	5	any	any	DT
cord-018804-wj35q88f	147	6	mutation	mutation	NN
cord-018804-wj35q88f	147	7	present	present	JJ
cord-018804-wj35q88f	147	8	in	in	IN
cord-018804-wj35q88f	147	9	the	the	DT
cord-018804-wj35q88f	147	10	founder	founder	NN
cord-018804-wj35q88f	147	11	genomes	genome	NNS
cord-018804-wj35q88f	147	12	will	will	MD
cord-018804-wj35q88f	147	13	have	have	VB
cord-018804-wj35q88f	147	14	a	a	DT
cord-018804-wj35q88f	147	15	high	high	JJ
cord-018804-wj35q88f	147	16	probability	probability	NN
cord-018804-wj35q88f	147	17	of	of	IN
cord-018804-wj35q88f	147	18	being	be	VBG
cord-018804-wj35q88f	147	19	transmitted	transmit	VBN
cord-018804-wj35q88f	147	20	to	to	IN
cord-018804-wj35q88f	147	21	the	the	DT
cord-018804-wj35q88f	147	22	progeny	progeny	NN
cord-018804-wj35q88f	147	23	,	,	,
cord-018804-wj35q88f	147	24	accelerating	accelerate	VBG
cord-018804-wj35q88f	147	25	in	in	IN
cord-018804-wj35q88f	147	26	this	this	DT
cord-018804-wj35q88f	147	27	way	way	NN
cord-018804-wj35q88f	147	28	the	the	DT
cord-018804-wj35q88f	147	29	rate	rate	NN
cord-018804-wj35q88f	147	30	of	of	IN
cord-018804-wj35q88f	147	31	fixation	fixation	NN
cord-018804-wj35q88f	147	32	of	of	IN
cord-018804-wj35q88f	147	33	mutations	mutation	NNS
cord-018804-wj35q88f	147	34	(	(	-LRB-
cord-018804-wj35q88f	147	35	Fig	fig	NN
cord-018804-wj35q88f	147	36	.	.	.
cord-018804-wj35q88f	147	37	15.1	15.1	CD
cord-018804-wj35q88f	147	38	)	)	-RRB-
cord-018804-wj35q88f	147	39	.	.	.
cord-018804-wj35q88f	148	1	Since	since	IN
cord-018804-wj35q88f	148	2	most	most	JJS
cord-018804-wj35q88f	148	3	mutations	mutation	NNS
cord-018804-wj35q88f	148	4	are	be	VBP
cord-018804-wj35q88f	148	5	deleterious	deleterious	JJ
cord-018804-wj35q88f	148	6	,	,	,
cord-018804-wj35q88f	148	7	the	the	DT
cord-018804-wj35q88f	148	8	expected	expect	VBN
cord-018804-wj35q88f	148	9	effect	effect	NN
cord-018804-wj35q88f	148	10	of	of	IN
cord-018804-wj35q88f	148	11	their	-PRON-	PRP$
cord-018804-wj35q88f	148	12	accumulation	accumulation	NN
cord-018804-wj35q88f	148	13	through	through	IN
cord-018804-wj35q88f	148	14	repeated	repeat	VBN
cord-018804-wj35q88f	148	15	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	148	16	is	be	VBZ
cord-018804-wj35q88f	148	17	a	a	DT
cord-018804-wj35q88f	148	18	decrease	decrease	NN
cord-018804-wj35q88f	148	19	in	in	IN
cord-018804-wj35q88f	148	20	the	the	DT
cord-018804-wj35q88f	148	21	Mutant	Mutant	NNP
cord-018804-wj35q88f	148	22	spectrum	spectrum	NN
cord-018804-wj35q88f	148	23	Consensus	Consensus	NNP
cord-018804-wj35q88f	148	24	sequence	sequence	NN
cord-018804-wj35q88f	148	25	Fig	Fig	NNP
cord-018804-wj35q88f	148	26	.	.	.
cord-018804-wj35q88f	149	1	15.1	15.1	CD
cord-018804-wj35q88f	149	2	.	.	.
cord-018804-wj35q88f	150	1	Accumulation	accumulation	NN
cord-018804-wj35q88f	150	2	of	of	IN
cord-018804-wj35q88f	150	3	mutations	mutation	NNS
cord-018804-wj35q88f	150	4	in	in	IN
cord-018804-wj35q88f	150	5	the	the	DT
cord-018804-wj35q88f	150	6	consensus	consensus	NN
cord-018804-wj35q88f	150	7	sequence	sequence	NN
cord-018804-wj35q88f	150	8	of	of	IN
cord-018804-wj35q88f	150	9	a	a	DT
cord-018804-wj35q88f	150	10	heterogeneous	heterogeneous	JJ
cord-018804-wj35q88f	150	11	virus	virus	NN
cord-018804-wj35q88f	150	12	population	population	NN
cord-018804-wj35q88f	150	13	when	when	WRB
cord-018804-wj35q88f	150	14	a	a	DT
cord-018804-wj35q88f	150	15	single	single	JJ
cord-018804-wj35q88f	150	16	genome	genome	NN
cord-018804-wj35q88f	150	17	(	(	-LRB-
cord-018804-wj35q88f	150	18	in	in	IN
cord-018804-wj35q88f	150	19	the	the	DT
cord-018804-wj35q88f	150	20	box	box	NN
cord-018804-wj35q88f	150	21	)	)	-RRB-
cord-018804-wj35q88f	150	22	is	be	VBZ
cord-018804-wj35q88f	150	23	selected	select	VBN
cord-018804-wj35q88f	150	24	to	to	TO
cord-018804-wj35q88f	150	25	found	find	VBN
cord-018804-wj35q88f	150	26	a	a	DT
cord-018804-wj35q88f	150	27	new	new	JJ
cord-018804-wj35q88f	150	28	population	population	NN
cord-018804-wj35q88f	150	29	.	.	.
cord-018804-wj35q88f	151	1	All	all	PDT
cord-018804-wj35q88f	151	2	the	the	DT
cord-018804-wj35q88f	151	3	mutations	mutation	NNS
cord-018804-wj35q88f	151	4	carried	carry	VBN
cord-018804-wj35q88f	151	5	by	by	IN
cord-018804-wj35q88f	151	6	this	this	DT
cord-018804-wj35q88f	151	7	genome	genome	NN
cord-018804-wj35q88f	151	8	are	be	VBP
cord-018804-wj35q88f	151	9	transmitted	transmit	VBN
cord-018804-wj35q88f	151	10	to	to	IN
cord-018804-wj35q88f	151	11	the	the	DT
cord-018804-wj35q88f	151	12	progeny	progeny	NN
cord-018804-wj35q88f	151	13	,	,	,
cord-018804-wj35q88f	151	14	and	and	CC
cord-018804-wj35q88f	151	15	consequently	consequently	RB
cord-018804-wj35q88f	151	16	they	-PRON-	PRP
cord-018804-wj35q88f	151	17	will	will	MD
cord-018804-wj35q88f	151	18	be	be	VB
cord-018804-wj35q88f	151	19	fixed	fix	VBN
cord-018804-wj35q88f	151	20	in	in	IN
cord-018804-wj35q88f	151	21	the	the	DT
cord-018804-wj35q88f	151	22	consensus	consensus	NN
cord-018804-wj35q88f	151	23	sequence	sequence	NN
cord-018804-wj35q88f	151	24	average	average	JJ
cord-018804-wj35q88f	151	25	fitness	fitness	NN
cord-018804-wj35q88f	151	26	that	that	WDT
cord-018804-wj35q88f	151	27	eventually	eventually	RB
cord-018804-wj35q88f	151	28	could	could	MD
cord-018804-wj35q88f	151	29	lead	lead	VB
cord-018804-wj35q88f	151	30	to	to	IN
cord-018804-wj35q88f	151	31	the	the	DT
cord-018804-wj35q88f	151	32	extinction	extinction	NN
cord-018804-wj35q88f	151	33	of	of	IN
cord-018804-wj35q88f	151	34	the	the	DT
cord-018804-wj35q88f	151	35	population	population	NN
cord-018804-wj35q88f	151	36	.	.	.
cord-018804-wj35q88f	152	1	Bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	152	2	are	be	VBP
cord-018804-wj35q88f	152	3	very	very	RB
cord-018804-wj35q88f	152	4	frequent	frequent	JJ
cord-018804-wj35q88f	152	5	in	in	IN
cord-018804-wj35q88f	152	6	nature	nature	NN
cord-018804-wj35q88f	152	7	,	,	,
cord-018804-wj35q88f	152	8	during	during	IN
cord-018804-wj35q88f	152	9	the	the	DT
cord-018804-wj35q88f	152	10	inter	inter	JJ
cord-018804-wj35q88f	152	11	-	-	JJ
cord-018804-wj35q88f	152	12	organ	organ	JJ
cord-018804-wj35q88f	152	13	or	or	CC
cord-018804-wj35q88f	152	14	inter	inter	JJ
cord-018804-wj35q88f	152	15	-	-	JJ
cord-018804-wj35q88f	152	16	host	host	JJ
cord-018804-wj35q88f	152	17	transmission	transmission	NN
cord-018804-wj35q88f	152	18	of	of	IN
cord-018804-wj35q88f	152	19	many	many	JJ
cord-018804-wj35q88f	152	20	viruses	virus	NNS
cord-018804-wj35q88f	152	21	.	.	.
cord-018804-wj35q88f	153	1	Thus	thus	RB
cord-018804-wj35q88f	153	2	,	,	,
cord-018804-wj35q88f	153	3	in	in	IN
cord-018804-wj35q88f	153	4	each	each	DT
cord-018804-wj35q88f	153	5	new	new	JJ
cord-018804-wj35q88f	153	6	infected	infected	JJ
cord-018804-wj35q88f	153	7	organism	organism	NN
cord-018804-wj35q88f	153	8	,	,	,
cord-018804-wj35q88f	153	9	the	the	DT
cord-018804-wj35q88f	153	10	quasispecies	quasispecie	NNS
cord-018804-wj35q88f	153	11	must	must	MD
cord-018804-wj35q88f	153	12	be	be	VB
cord-018804-wj35q88f	153	13	rebuilt	rebuild	VBN
cord-018804-wj35q88f	153	14	from	from	IN
cord-018804-wj35q88f	153	15	one	one	CD
cord-018804-wj35q88f	153	16	or	or	CC
cord-018804-wj35q88f	153	17	a	a	DT
cord-018804-wj35q88f	153	18	few	few	JJ
cord-018804-wj35q88f	153	19	founder	founder	NN
cord-018804-wj35q88f	153	20	genomes	genome	NNS
cord-018804-wj35q88f	153	21	,	,	,
cord-018804-wj35q88f	153	22	a	a	DT
cord-018804-wj35q88f	153	23	fact	fact	NN
cord-018804-wj35q88f	153	24	that	that	WDT
cord-018804-wj35q88f	153	25	could	could	MD
cord-018804-wj35q88f	153	26	lead	lead	VB
cord-018804-wj35q88f	153	27	to	to	IN
cord-018804-wj35q88f	153	28	a	a	DT
cord-018804-wj35q88f	153	29	wide	wide	JJ
cord-018804-wj35q88f	153	30	diversity	diversity	NN
cord-018804-wj35q88f	153	31	in	in	IN
cord-018804-wj35q88f	153	32	diseases	disease	NNS
cord-018804-wj35q88f	153	33	in	in	IN
cord-018804-wj35q88f	153	34	which	which	WDT
cord-018804-wj35q88f	153	35	the	the	DT
cord-018804-wj35q88f	153	36	usual	usual	JJ
cord-018804-wj35q88f	153	37	form	form	NN
cord-018804-wj35q88f	153	38	of	of	IN
cord-018804-wj35q88f	153	39	transmission	transmission	NN
cord-018804-wj35q88f	153	40	is	be	VBZ
cord-018804-wj35q88f	153	41	mediated	mediate	VBN
cord-018804-wj35q88f	153	42	through	through	IN
cord-018804-wj35q88f	153	43	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	153	44	.	.	.
cord-018804-wj35q88f	154	1	The	the	DT
cord-018804-wj35q88f	154	2	persistence	persistence	NN
cord-018804-wj35q88f	154	3	of	of	IN
cord-018804-wj35q88f	154	4	viruses	virus	NNS
cord-018804-wj35q88f	154	5	in	in	IN
cord-018804-wj35q88f	154	6	nature	nature	NN
cord-018804-wj35q88f	154	7	and	and	CC
cord-018804-wj35q88f	154	8	the	the	DT
cord-018804-wj35q88f	154	9	limited	limited	JJ
cord-018804-wj35q88f	154	10	number	number	NN
cord-018804-wj35q88f	154	11	of	of	IN
cord-018804-wj35q88f	154	12	circulating	circulate	VBG
cord-018804-wj35q88f	154	13	strains	strain	NNS
cord-018804-wj35q88f	154	14	in	in	IN
cord-018804-wj35q88f	154	15	diseases	disease	NNS
cord-018804-wj35q88f	154	16	such	such	JJ
cord-018804-wj35q88f	154	17	as	as	IN
cord-018804-wj35q88f	154	18	influenza	influenza	NN
cord-018804-wj35q88f	154	19	,	,	,
cord-018804-wj35q88f	154	20	despite	despite	IN
cord-018804-wj35q88f	154	21	the	the	DT
cord-018804-wj35q88f	154	22	frequent	frequent	JJ
cord-018804-wj35q88f	154	23	occurrence	occurrence	NN
cord-018804-wj35q88f	154	24	of	of	IN
cord-018804-wj35q88f	154	25	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	154	26	,	,	,
cord-018804-wj35q88f	154	27	is	be	VBZ
cord-018804-wj35q88f	154	28	paradoxical	paradoxical	JJ
cord-018804-wj35q88f	154	29	[	[	-LRB-
cord-018804-wj35q88f	154	30	36	36	CD
cord-018804-wj35q88f	154	31	]	]	-RRB-
cord-018804-wj35q88f	154	32	.	.	.
cord-018804-wj35q88f	155	1	It	-PRON-	PRP
cord-018804-wj35q88f	155	2	is	be	VBZ
cord-018804-wj35q88f	155	3	believed	believe	VBN
cord-018804-wj35q88f	155	4	that	that	IN
cord-018804-wj35q88f	155	5	the	the	DT
cord-018804-wj35q88f	155	6	inter	inter	JJ
cord-018804-wj35q88f	155	7	-	-	JJ
cord-018804-wj35q88f	155	8	host	host	JJ
cord-018804-wj35q88f	155	9	competition	competition	NN
cord-018804-wj35q88f	155	10	that	that	WDT
cord-018804-wj35q88f	155	11	can	can	MD
cord-018804-wj35q88f	155	12	induce	induce	VB
cord-018804-wj35q88f	155	13	stochastic	stochastic	JJ
cord-018804-wj35q88f	155	14	losses	loss	NNS
cord-018804-wj35q88f	155	15	of	of	IN
cord-018804-wj35q88f	155	16	the	the	DT
cord-018804-wj35q88f	155	17	less	less	RBR
cord-018804-wj35q88f	155	18	fit	fit	JJ
cord-018804-wj35q88f	155	19	variants	variant	NNS
cord-018804-wj35q88f	155	20	,	,	,
cord-018804-wj35q88f	155	21	together	together	RB
cord-018804-wj35q88f	155	22	with	with	IN
cord-018804-wj35q88f	155	23	the	the	DT
cord-018804-wj35q88f	155	24	action	action	NN
cord-018804-wj35q88f	155	25	of	of	IN
cord-018804-wj35q88f	155	26	previous	previous	JJ
cord-018804-wj35q88f	155	27	immune	immune	JJ
cord-018804-wj35q88f	155	28	responses	response	NNS
cord-018804-wj35q88f	155	29	on	on	IN
cord-018804-wj35q88f	155	30	genetically	genetically	RB
cord-018804-wj35q88f	155	31	related	relate	VBN
cord-018804-wj35q88f	155	32	virus	virus	NN
cord-018804-wj35q88f	155	33	variants	variant	NNS
cord-018804-wj35q88f	155	34	(	(	-LRB-
cord-018804-wj35q88f	155	35	the	the	DT
cord-018804-wj35q88f	155	36	so	so	RB
cord-018804-wj35q88f	155	37	called	call	VBN
cord-018804-wj35q88f	155	38	cross	cross	NN
cord-018804-wj35q88f	155	39	-	-	NN
cord-018804-wj35q88f	155	40	immunity	immunity	NN
cord-018804-wj35q88f	155	41	)	)	-RRB-
cord-018804-wj35q88f	155	42	are	be	VBP
cord-018804-wj35q88f	155	43	factors	factor	NNS
cord-018804-wj35q88f	155	44	that	that	WDT
cord-018804-wj35q88f	155	45	restrict	restrict	VBP
cord-018804-wj35q88f	155	46	the	the	DT
cord-018804-wj35q88f	155	47	strain	strain	NN
cord-018804-wj35q88f	155	48	diversity	diversity	NN
cord-018804-wj35q88f	155	49	.	.	.
cord-018804-wj35q88f	156	1	The	the	DT
cord-018804-wj35q88f	156	2	intra	intra	JJ
cord-018804-wj35q88f	156	3	-	-	JJ
cord-018804-wj35q88f	156	4	host	host	JJ
cord-018804-wj35q88f	156	5	competition	competition	NN
cord-018804-wj35q88f	156	6	that	that	WDT
cord-018804-wj35q88f	156	7	takes	take	VBZ
cord-018804-wj35q88f	156	8	place	place	NN
cord-018804-wj35q88f	156	9	after	after	IN
cord-018804-wj35q88f	156	10	each	each	DT
cord-018804-wj35q88f	156	11	transmission	transmission	NN
cord-018804-wj35q88f	156	12	event	event	NN
cord-018804-wj35q88f	156	13	is	be	VBZ
cord-018804-wj35q88f	156	14	an	an	DT
cord-018804-wj35q88f	156	15	additional	additional	JJ
cord-018804-wj35q88f	156	16	factor	factor	NN
cord-018804-wj35q88f	156	17	that	that	WDT
cord-018804-wj35q88f	156	18	favours	favour	VBZ
cord-018804-wj35q88f	156	19	the	the	DT
cord-018804-wj35q88f	156	20	optimization	optimization	NN
cord-018804-wj35q88f	156	21	of	of	IN
cord-018804-wj35q88f	156	22	the	the	DT
cord-018804-wj35q88f	156	23	viral	viral	JJ
cord-018804-wj35q88f	156	24	population	population	NN
cord-018804-wj35q88f	156	25	inside	inside	IN
cord-018804-wj35q88f	156	26	each	each	DT
cord-018804-wj35q88f	156	27	infected	infect	VBN
cord-018804-wj35q88f	156	28	individual	individual	NN
cord-018804-wj35q88f	156	29	and	and	CC
cord-018804-wj35q88f	156	30	also	also	RB
cord-018804-wj35q88f	156	31	contributing	contribute	VBG
cord-018804-wj35q88f	156	32	to	to	IN
cord-018804-wj35q88f	156	33	the	the	DT
cord-018804-wj35q88f	156	34	resistance	resistance	NN
cord-018804-wj35q88f	156	35	to	to	IN
cord-018804-wj35q88f	156	36	extinction	extinction	NN
cord-018804-wj35q88f	156	37	of	of	IN
cord-018804-wj35q88f	156	38	viruses	virus	NNS
cord-018804-wj35q88f	156	39	transmitted	transmit	VBN
cord-018804-wj35q88f	156	40	through	through	IN
cord-018804-wj35q88f	156	41	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	156	42	.	.	.
cord-018804-wj35q88f	157	1	Grenfell	Grenfell	NNP
cord-018804-wj35q88f	157	2	et	et	FW
cord-018804-wj35q88f	157	3	al	al	NNP
cord-018804-wj35q88f	157	4	.	.	.
cord-018804-wj35q88f	158	1	[	[	-LRB-
cord-018804-wj35q88f	158	2	37	37	CD
cord-018804-wj35q88f	158	3	]	]	-RRB-
cord-018804-wj35q88f	158	4	have	have	VBP
cord-018804-wj35q88f	158	5	classified	classify	VBN
cord-018804-wj35q88f	158	6	RNA	RNA	NNP
cord-018804-wj35q88f	158	7	viruses	virus	NNS
cord-018804-wj35q88f	158	8	in	in	IN
cord-018804-wj35q88f	158	9	four	four	CD
cord-018804-wj35q88f	158	10	phylodynamic	phylodynamic	JJ
cord-018804-wj35q88f	158	11	categories	category	NNS
cord-018804-wj35q88f	158	12	,	,	,
cord-018804-wj35q88f	158	13	according	accord	VBG
cord-018804-wj35q88f	158	14	to	to	IN
cord-018804-wj35q88f	158	15	factors	factor	NNS
cord-018804-wj35q88f	158	16	pertaining	pertain	VBG
cord-018804-wj35q88f	158	17	to	to	IN
cord-018804-wj35q88f	158	18	the	the	DT
cord-018804-wj35q88f	158	19	host	host	NN
cord-018804-wj35q88f	158	20	-	-	HYPH
cord-018804-wj35q88f	158	21	pathogen	pathogen	NN
cord-018804-wj35q88f	158	22	interactions	interaction	NNS
cord-018804-wj35q88f	158	23	(	(	-LRB-
cord-018804-wj35q88f	158	24	mainly	mainly	RB
cord-018804-wj35q88f	158	25	the	the	DT
cord-018804-wj35q88f	158	26	duration	duration	NN
cord-018804-wj35q88f	158	27	of	of	IN
cord-018804-wj35q88f	158	28	the	the	DT
cord-018804-wj35q88f	158	29	infection	infection	NN
cord-018804-wj35q88f	158	30	and	and	CC
cord-018804-wj35q88f	158	31	the	the	DT
cord-018804-wj35q88f	158	32	nature	nature	NN
cord-018804-wj35q88f	158	33	and	and	CC
cord-018804-wj35q88f	158	34	strength	strength	NN
cord-018804-wj35q88f	158	35	of	of	IN
cord-018804-wj35q88f	158	36	the	the	DT
cord-018804-wj35q88f	158	37	immune	immune	JJ
cord-018804-wj35q88f	158	38	response	response	NN
cord-018804-wj35q88f	158	39	)	)	-RRB-
cord-018804-wj35q88f	158	40	.	.	.
cord-018804-wj35q88f	159	1	They	-PRON-	PRP
cord-018804-wj35q88f	159	2	are	be	VBP
cord-018804-wj35q88f	159	3	briefly	briefly	RB
cord-018804-wj35q88f	159	4	described	describe	VBN
cord-018804-wj35q88f	159	5	:	:	:
cord-018804-wj35q88f	159	6	1	1	CD
cord-018804-wj35q88f	159	7	.	.	.
cord-018804-wj35q88f	160	1	Short	short	JJ
cord-018804-wj35q88f	160	2	infections	infection	NNS
cord-018804-wj35q88f	160	3	with	with	IN
cord-018804-wj35q88f	160	4	strong	strong	JJ
cord-018804-wj35q88f	160	5	cross	cross	NN
cord-018804-wj35q88f	160	6	-	-	NN
cord-018804-wj35q88f	160	7	immunity	immunity	NN
cord-018804-wj35q88f	160	8	.	.	.
cord-018804-wj35q88f	161	1	The	the	DT
cord-018804-wj35q88f	161	2	best	well	RBS
cord-018804-wj35q88f	161	3	known	know	VBN
cord-018804-wj35q88f	161	4	viruses	virus	NNS
cord-018804-wj35q88f	161	5	included	include	VBN
cord-018804-wj35q88f	161	6	in	in	IN
cord-018804-wj35q88f	161	7	this	this	DT
cord-018804-wj35q88f	161	8	category	category	NN
cord-018804-wj35q88f	161	9	belong	belong	VBP
cord-018804-wj35q88f	161	10	to	to	IN
cord-018804-wj35q88f	161	11	the	the	DT
cord-018804-wj35q88f	161	12	family	family	NN
cord-018804-wj35q88f	161	13	of	of	IN
cord-018804-wj35q88f	161	14	morbilliviruses	morbilliviruses	NNPS
cord-018804-wj35q88f	161	15	(	(	-LRB-
cord-018804-wj35q88f	161	16	measles	measle	NNS
cord-018804-wj35q88f	161	17	being	be	VBG
cord-018804-wj35q88f	161	18	a	a	DT
cord-018804-wj35q88f	161	19	well	well	RB
cord-018804-wj35q88f	161	20	studied	study	VBN
cord-018804-wj35q88f	161	21	example	example	NN
cord-018804-wj35q88f	161	22	)	)	-RRB-
cord-018804-wj35q88f	161	23	.	.	.
cord-018804-wj35q88f	162	1	In	in	IN
cord-018804-wj35q88f	162	2	these	these	DT
cord-018804-wj35q88f	162	3	viruses	virus	NNS
cord-018804-wj35q88f	162	4	,	,	,
cord-018804-wj35q88f	162	5	epidemic	epidemic	NN
cord-018804-wj35q88f	162	6	cycles	cycle	NNS
cord-018804-wj35q88f	162	7	are	be	VBP
cord-018804-wj35q88f	162	8	mainly	mainly	RB
cord-018804-wj35q88f	162	9	determined	determine	VBN
cord-018804-wj35q88f	162	10	by	by	IN
cord-018804-wj35q88f	162	11	the	the	DT
cord-018804-wj35q88f	162	12	lifelong	lifelong	JJ
cord-018804-wj35q88f	162	13	immunity	immunity	NN
cord-018804-wj35q88f	162	14	elicited	elicit	VBN
cord-018804-wj35q88f	162	15	by	by	IN
cord-018804-wj35q88f	162	16	the	the	DT
cord-018804-wj35q88f	162	17	pathogen	pathogen	NN
cord-018804-wj35q88f	162	18	,	,	,
cord-018804-wj35q88f	162	19	which	which	WDT
cord-018804-wj35q88f	162	20	causes	cause	VBZ
cord-018804-wj35q88f	162	21	that	that	IN
cord-018804-wj35q88f	162	22	the	the	DT
cord-018804-wj35q88f	162	23	renewal	renewal	NN
cord-018804-wj35q88f	162	24	of	of	IN
cord-018804-wj35q88f	162	25	susceptible	susceptible	JJ
cord-018804-wj35q88f	162	26	hosts	host	NNS
cord-018804-wj35q88f	162	27	takes	take	VBZ
cord-018804-wj35q88f	162	28	place	place	NN
cord-018804-wj35q88f	162	29	only	only	RB
cord-018804-wj35q88f	162	30	at	at	IN
cord-018804-wj35q88f	162	31	the	the	DT
cord-018804-wj35q88f	162	32	birth	birth	NN
cord-018804-wj35q88f	162	33	of	of	IN
cord-018804-wj35q88f	162	34	new	new	JJ
cord-018804-wj35q88f	162	35	individuals	individual	NNS
cord-018804-wj35q88f	162	36	.	.	.
cord-018804-wj35q88f	163	1	The	the	DT
cord-018804-wj35q88f	163	2	existence	existence	NN
cord-018804-wj35q88f	163	3	of	of	IN
cord-018804-wj35q88f	163	4	a	a	DT
cord-018804-wj35q88f	163	5	strong	strong	JJ
cord-018804-wj35q88f	163	6	immune	immune	JJ
cord-018804-wj35q88f	163	7	response	response	NN
cord-018804-wj35q88f	163	8	that	that	WDT
cord-018804-wj35q88f	163	9	is	be	VBZ
cord-018804-wj35q88f	163	10	powerful	powerful	JJ
cord-018804-wj35q88f	163	11	against	against	IN
cord-018804-wj35q88f	163	12	all	all	DT
cord-018804-wj35q88f	163	13	circulating	circulate	VBG
cord-018804-wj35q88f	163	14	strains	strain	NNS
cord-018804-wj35q88f	163	15	(	(	-LRB-
cord-018804-wj35q88f	163	16	strain	strain	NN
cord-018804-wj35q88f	163	17	-	-	HYPH
cord-018804-wj35q88f	163	18	transcending	transcend	VBG
cord-018804-wj35q88f	163	19	immunity	immunity	NN
cord-018804-wj35q88f	163	20	)	)	-RRB-
cord-018804-wj35q88f	163	21	would	would	MD
cord-018804-wj35q88f	163	22	prevent	prevent	VB
cord-018804-wj35q88f	163	23	the	the	DT
cord-018804-wj35q88f	163	24	action	action	NN
cord-018804-wj35q88f	163	25	of	of	IN
cord-018804-wj35q88f	163	26	selection	selection	NN
cord-018804-wj35q88f	163	27	.	.	.
cord-018804-wj35q88f	164	1	In	in	IN
cord-018804-wj35q88f	164	2	these	these	DT
cord-018804-wj35q88f	164	3	viruses	virus	NNS
cord-018804-wj35q88f	164	4	,	,	,
cord-018804-wj35q88f	164	5	the	the	DT
cord-018804-wj35q88f	164	6	burden	burden	NN
cord-018804-wj35q88f	164	7	of	of	IN
cord-018804-wj35q88f	164	8	many	many	JJ
cord-018804-wj35q88f	164	9	different	different	JJ
cord-018804-wj35q88f	164	10	strains	strain	NNS
cord-018804-wj35q88f	164	11	seems	seem	VBZ
cord-018804-wj35q88f	164	12	to	to	TO
cord-018804-wj35q88f	164	13	be	be	VB
cord-018804-wj35q88f	164	14	limited	limit	VBN
cord-018804-wj35q88f	164	15	by	by	IN
cord-018804-wj35q88f	164	16	spatio	spatio	JJ
cord-018804-wj35q88f	164	17	-	-	HYPH
cord-018804-wj35q88f	164	18	temporal	temporal	JJ
cord-018804-wj35q88f	164	19	parameters	parameter	NNS
cord-018804-wj35q88f	164	20	of	of	IN
cord-018804-wj35q88f	164	21	the	the	DT
cord-018804-wj35q88f	164	22	dynamics	dynamic	NNS
cord-018804-wj35q88f	164	23	of	of	IN
cord-018804-wj35q88f	164	24	the	the	DT
cord-018804-wj35q88f	164	25	epidemic	epidemic	NN
cord-018804-wj35q88f	164	26	process	process	NN
cord-018804-wj35q88f	164	27	.	.	.
cord-018804-wj35q88f	165	1	2	2	LS
cord-018804-wj35q88f	165	2	.	.	.
cord-018804-wj35q88f	166	1	Short	short	JJ
cord-018804-wj35q88f	166	2	infections	infection	NNS
cord-018804-wj35q88f	166	3	with	with	IN
cord-018804-wj35q88f	166	4	partial	partial	JJ
cord-018804-wj35q88f	166	5	cross	cross	NN
cord-018804-wj35q88f	166	6	-	-	NN
cord-018804-wj35q88f	166	7	immunity	immunity	NN
cord-018804-wj35q88f	166	8	.	.	.
cord-018804-wj35q88f	167	1	The	the	DT
cord-018804-wj35q88f	167	2	best	good	JJS
cord-018804-wj35q88f	167	3	example	example	NN
cord-018804-wj35q88f	167	4	of	of	IN
cord-018804-wj35q88f	167	5	this	this	DT
cord-018804-wj35q88f	167	6	category	category	NN
cord-018804-wj35q88f	167	7	is	be	VBZ
cord-018804-wj35q88f	167	8	influenza	influenza	NN
cord-018804-wj35q88f	167	9	A	a	DT
cord-018804-wj35q88f	167	10	virus	virus	NN
cord-018804-wj35q88f	167	11	.	.	.
cord-018804-wj35q88f	168	1	The	the	DT
cord-018804-wj35q88f	168	2	high	high	JJ
cord-018804-wj35q88f	168	3	mutation	mutation	NN
cord-018804-wj35q88f	168	4	rate	rate	NN
cord-018804-wj35q88f	168	5	characteristic	characteristic	NN
cord-018804-wj35q88f	168	6	of	of	IN
cord-018804-wj35q88f	168	7	RNA	RNA	NNP
cord-018804-wj35q88f	168	8	viruses	virus	NNS
cord-018804-wj35q88f	168	9	,	,	,
cord-018804-wj35q88f	168	10	together	together	RB
cord-018804-wj35q88f	168	11	with	with	IN
cord-018804-wj35q88f	168	12	the	the	DT
cord-018804-wj35q88f	168	13	transmission	transmission	NN
cord-018804-wj35q88f	168	14	of	of	IN
cord-018804-wj35q88f	168	15	influenza	influenza	NN
cord-018804-wj35q88f	168	16	through	through	IN
cord-018804-wj35q88f	168	17	bottleneck	bottleneck	NN
cord-018804-wj35q88f	168	18	events	event	NNS
cord-018804-wj35q88f	168	19	,	,	,
cord-018804-wj35q88f	168	20	opposes	oppose	VBZ
cord-018804-wj35q88f	168	21	to	to	IN
cord-018804-wj35q88f	168	22	the	the	DT
cord-018804-wj35q88f	168	23	limited	limited	JJ
cord-018804-wj35q88f	168	24	variability	variability	NN
cord-018804-wj35q88f	168	25	within	within	IN
cord-018804-wj35q88f	168	26	lineages	lineage	NNS
cord-018804-wj35q88f	168	27	.	.	.
cord-018804-wj35q88f	169	1	In	in	IN
cord-018804-wj35q88f	169	2	contrast	contrast	NN
cord-018804-wj35q88f	169	3	to	to	IN
cord-018804-wj35q88f	169	4	measles	measle	NNS
cord-018804-wj35q88f	169	5	,	,	,
cord-018804-wj35q88f	169	6	cross	cross	NN
cord-018804-wj35q88f	169	7	-	-	NN
cord-018804-wj35q88f	169	8	immunity	immunity	NN
cord-018804-wj35q88f	169	9	against	against	IN
cord-018804-wj35q88f	169	10	virus	virus	NN
cord-018804-wj35q88f	169	11	variants	variant	NNS
cord-018804-wj35q88f	169	12	is	be	VBZ
cord-018804-wj35q88f	169	13	only	only	RB
cord-018804-wj35q88f	169	14	partial	partial	JJ
cord-018804-wj35q88f	169	15	and	and	CC
cord-018804-wj35q88f	169	16	the	the	DT
cord-018804-wj35q88f	169	17	replacement	replacement	NN
cord-018804-wj35q88f	169	18	of	of	IN
cord-018804-wj35q88f	169	19	susceptible	susceptible	JJ
cord-018804-wj35q88f	169	20	individuals	individual	NNS
cord-018804-wj35q88f	169	21	takes	take	VBZ
cord-018804-wj35q88f	169	22	place	place	NN
cord-018804-wj35q88f	169	23	,	,	,
cord-018804-wj35q88f	169	24	not	not	RB
cord-018804-wj35q88f	169	25	only	only	RB
cord-018804-wj35q88f	169	26	through	through	IN
cord-018804-wj35q88f	169	27	the	the	DT
cord-018804-wj35q88f	169	28	birth	birth	NN
cord-018804-wj35q88f	169	29	of	of	IN
cord-018804-wj35q88f	169	30	new	new	JJ
cord-018804-wj35q88f	169	31	hosts	host	NNS
cord-018804-wj35q88f	169	32	but	but	CC
cord-018804-wj35q88f	169	33	also	also	RB
cord-018804-wj35q88f	169	34	through	through	IN
cord-018804-wj35q88f	169	35	generation	generation	NN
cord-018804-wj35q88f	169	36	of	of	IN
cord-018804-wj35q88f	169	37	new	new	JJ
cord-018804-wj35q88f	169	38	influenza	influenza	NN
cord-018804-wj35q88f	169	39	strains	strain	NNS
cord-018804-wj35q88f	169	40	that	that	WDT
cord-018804-wj35q88f	169	41	may	may	MD
cord-018804-wj35q88f	169	42	affect	affect	VB
cord-018804-wj35q88f	169	43	individuals	individual	NNS
cord-018804-wj35q88f	169	44	previously	previously	RB
cord-018804-wj35q88f	169	45	exposed	expose	VBN
cord-018804-wj35q88f	169	46	to	to	IN
cord-018804-wj35q88f	169	47	the	the	DT
cord-018804-wj35q88f	169	48	virus	virus	NN
cord-018804-wj35q88f	169	49	.	.	.
cord-018804-wj35q88f	170	1	Evolution	evolution	NN
cord-018804-wj35q88f	170	2	of	of	IN
cord-018804-wj35q88f	170	3	influenza	influenza	NN
cord-018804-wj35q88f	170	4	and	and	CC
cord-018804-wj35q88f	170	5	its	-PRON-	PRP$
cord-018804-wj35q88f	170	6	epidemic	epidemic	NN
cord-018804-wj35q88f	170	7	dynamics	dynamic	NNS
cord-018804-wj35q88f	170	8	have	have	VBP
cord-018804-wj35q88f	170	9	been	be	VBN
cord-018804-wj35q88f	170	10	modelled	model	VBN
cord-018804-wj35q88f	170	11	in	in	IN
cord-018804-wj35q88f	170	12	several	several	JJ
cord-018804-wj35q88f	170	13	studies	study	NNS
cord-018804-wj35q88f	170	14	,	,	,
cord-018804-wj35q88f	170	15	trying	try	VBG
cord-018804-wj35q88f	170	16	to	to	TO
cord-018804-wj35q88f	170	17	reproduce	reproduce	VB
cord-018804-wj35q88f	170	18	the	the	DT
cord-018804-wj35q88f	170	19	strong	strong	JJ
cord-018804-wj35q88f	170	20	seasonality	seasonality	NN
cord-018804-wj35q88f	170	21	of	of	IN
cord-018804-wj35q88f	170	22	infections	infection	NNS
cord-018804-wj35q88f	170	23	and	and	CC
cord-018804-wj35q88f	170	24	the	the	DT
cord-018804-wj35q88f	170	25	replacement	replacement	NN
cord-018804-wj35q88f	170	26	of	of	IN
cord-018804-wj35q88f	170	27	strains	strain	NNS
cord-018804-wj35q88f	170	28	at	at	IN
cord-018804-wj35q88f	170	29	each	each	DT
cord-018804-wj35q88f	170	30	epidemic	epidemic	NN
cord-018804-wj35q88f	170	31	.	.	.
cord-018804-wj35q88f	171	1	The	the	DT
cord-018804-wj35q88f	171	2	most	most	RBS
cord-018804-wj35q88f	171	3	successful	successful	JJ
cord-018804-wj35q88f	171	4	models	model	NNS
cord-018804-wj35q88f	171	5	reproduce	reproduce	VBP
cord-018804-wj35q88f	171	6	the	the	DT
cord-018804-wj35q88f	171	7	behaviour	behaviour	NN
cord-018804-wj35q88f	171	8	of	of	IN
cord-018804-wj35q88f	171	9	influenza	influenza	NN
cord-018804-wj35q88f	171	10	epidemics	epidemic	NNS
cord-018804-wj35q88f	171	11	when	when	WRB
cord-018804-wj35q88f	171	12	a	a	DT
cord-018804-wj35q88f	171	13	short	short	RB
cord-018804-wj35q88f	171	14	-	-	HYPH
cord-018804-wj35q88f	171	15	lived	live	VBN
cord-018804-wj35q88f	171	16	straintranscending	straintranscending	JJ
cord-018804-wj35q88f	171	17	immunity	immunity	NN
cord-018804-wj35q88f	171	18	(	(	-LRB-
cord-018804-wj35q88f	171	19	in	in	IN
cord-018804-wj35q88f	171	20	contrast	contrast	NN
cord-018804-wj35q88f	171	21	to	to	IN
cord-018804-wj35q88f	171	22	the	the	DT
cord-018804-wj35q88f	171	23	long	long	RB
cord-018804-wj35q88f	171	24	-	-	HYPH
cord-018804-wj35q88f	171	25	lived	live	VBN
cord-018804-wj35q88f	171	26	immunity	immunity	NN
cord-018804-wj35q88f	171	27	characteristic	characteristic	NN
cord-018804-wj35q88f	171	28	of	of	IN
cord-018804-wj35q88f	171	29	viruses	virus	NNS
cord-018804-wj35q88f	171	30	in	in	IN
cord-018804-wj35q88f	171	31	the	the	DT
cord-018804-wj35q88f	171	32	previous	previous	JJ
cord-018804-wj35q88f	171	33	category	category	NN
cord-018804-wj35q88f	171	34	)	)	-RRB-
cord-018804-wj35q88f	171	35	is	be	VBZ
cord-018804-wj35q88f	171	36	included	include	VBN
cord-018804-wj35q88f	171	37	as	as	IN
cord-018804-wj35q88f	171	38	an	an	DT
cord-018804-wj35q88f	171	39	essential	essential	JJ
cord-018804-wj35q88f	171	40	factor	factor	NN
cord-018804-wj35q88f	171	41	limiting	limit	VBG
cord-018804-wj35q88f	171	42	viral	viral	JJ
cord-018804-wj35q88f	171	43	diversity	diversity	NN
cord-018804-wj35q88f	171	44	in	in	IN
cord-018804-wj35q88f	171	45	the	the	DT
cord-018804-wj35q88f	171	46	host	host	NN
cord-018804-wj35q88f	171	47	population	population	NN
cord-018804-wj35q88f	171	48	[	[	-LRB-
cord-018804-wj35q88f	171	49	36	36	CD
cord-018804-wj35q88f	171	50	]	]	-RRB-
cord-018804-wj35q88f	171	51	.	.	.
cord-018804-wj35q88f	172	1	However	however	RB
cord-018804-wj35q88f	172	2	,	,	,
cord-018804-wj35q88f	172	3	the	the	DT
cord-018804-wj35q88f	172	4	role	role	NN
cord-018804-wj35q88f	172	5	of	of	IN
cord-018804-wj35q88f	172	6	within	within	IN
cord-018804-wj35q88f	172	7	-	-	HYPH
cord-018804-wj35q88f	172	8	host	host	NN
cord-018804-wj35q88f	172	9	dynamics	dynamic	NNS
cord-018804-wj35q88f	172	10	after	after	IN
cord-018804-wj35q88f	172	11	each	each	DT
cord-018804-wj35q88f	172	12	bottleneck	bottleneck	NN
cord-018804-wj35q88f	172	13	mediating	mediate	VBG
cord-018804-wj35q88f	172	14	transmission	transmission	NN
cord-018804-wj35q88f	172	15	remains	remain	VBZ
cord-018804-wj35q88f	172	16	to	to	TO
cord-018804-wj35q88f	172	17	be	be	VB
cord-018804-wj35q88f	172	18	added	add	VBN
cord-018804-wj35q88f	172	19	to	to	IN
cord-018804-wj35q88f	172	20	the	the	DT
cord-018804-wj35q88f	172	21	epidemic	epidemic	NN
cord-018804-wj35q88f	172	22	model	model	NN
cord-018804-wj35q88f	172	23	.	.	.
cord-018804-wj35q88f	173	1	3	3	LS
cord-018804-wj35q88f	173	2	.	.	.
cord-018804-wj35q88f	174	1	Infections	infection	NNS
cord-018804-wj35q88f	174	2	with	with	IN
cord-018804-wj35q88f	174	3	immune	immune	JJ
cord-018804-wj35q88f	174	4	enhancement	enhancement	NN
cord-018804-wj35q88f	174	5	.	.	.
cord-018804-wj35q88f	175	1	These	these	DT
cord-018804-wj35q88f	175	2	are	be	VBP
cord-018804-wj35q88f	175	3	infections	infection	NNS
cord-018804-wj35q88f	175	4	with	with	IN
cord-018804-wj35q88f	175	5	the	the	DT
cord-018804-wj35q88f	175	6	possibility	possibility	NN
cord-018804-wj35q88f	175	7	of	of	IN
cord-018804-wj35q88f	175	8	antibody	antibody	NN
cord-018804-wj35q88f	175	9	-	-	HYPH
cord-018804-wj35q88f	175	10	dependent	dependent	JJ
cord-018804-wj35q88f	175	11	enhancement	enhancement	NN
cord-018804-wj35q88f	175	12	(	(	-LRB-
cord-018804-wj35q88f	175	13	ADE	ADE	NNP
cord-018804-wj35q88f	175	14	)	)	-RRB-
cord-018804-wj35q88f	175	15	.	.	.
cord-018804-wj35q88f	176	1	An	an	DT
cord-018804-wj35q88f	176	2	example	example	NN
cord-018804-wj35q88f	176	3	is	be	VBZ
cord-018804-wj35q88f	176	4	dengue	dengue	NN
cord-018804-wj35q88f	176	5	virus	virus	NN
cord-018804-wj35q88f	176	6	that	that	WDT
cord-018804-wj35q88f	176	7	comprises	comprise	VBZ
cord-018804-wj35q88f	176	8	four	four	CD
cord-018804-wj35q88f	176	9	serotypes	serotypes	NN
cord-018804-wj35q88f	176	10	co	co	NN
cord-018804-wj35q88f	176	11	-	-	NN
cord-018804-wj35q88f	176	12	circulating	circulate	VBG
cord-018804-wj35q88f	176	13	in	in	IN
cord-018804-wj35q88f	176	14	tropical	tropical	JJ
cord-018804-wj35q88f	176	15	regions	region	NNS
cord-018804-wj35q88f	176	16	.	.	.
cord-018804-wj35q88f	177	1	ADE	ADE	NNP
cord-018804-wj35q88f	177	2	causes	cause	VBZ
cord-018804-wj35q88f	177	3	that	that	IN
cord-018804-wj35q88f	177	4	secondary	secondary	JJ
cord-018804-wj35q88f	177	5	infections	infection	NNS
cord-018804-wj35q88f	177	6	produced	produce	VBN
cord-018804-wj35q88f	177	7	by	by	IN
cord-018804-wj35q88f	177	8	a	a	DT
cord-018804-wj35q88f	177	9	different	different	JJ
cord-018804-wj35q88f	177	10	virus	virus	NN
cord-018804-wj35q88f	177	11	serotype	serotype	NN
cord-018804-wj35q88f	177	12	usually	usually	RB
cord-018804-wj35q88f	177	13	curse	curse	VBP
cord-018804-wj35q88f	177	14	with	with	IN
cord-018804-wj35q88f	177	15	more	more	JJR
cord-018804-wj35q88f	177	16	severe	severe	JJ
cord-018804-wj35q88f	177	17	symptoms	symptom	NNS
cord-018804-wj35q88f	177	18	than	than	IN
cord-018804-wj35q88f	177	19	primary	primary	JJ
cord-018804-wj35q88f	177	20	infections	infection	NNS
cord-018804-wj35q88f	177	21	.	.	.
cord-018804-wj35q88f	178	1	4	4	LS
cord-018804-wj35q88f	178	2	.	.	.
cord-018804-wj35q88f	179	1	Persistent	persistent	JJ
cord-018804-wj35q88f	179	2	infections	infection	NNS
cord-018804-wj35q88f	179	3	.	.	.
cord-018804-wj35q88f	180	1	In	in	IN
cord-018804-wj35q88f	180	2	this	this	DT
cord-018804-wj35q88f	180	3	category	category	NN
cord-018804-wj35q88f	180	4	are	be	VBP
cord-018804-wj35q88f	180	5	included	include	VBN
cord-018804-wj35q88f	180	6	viruses	virus	NNS
cord-018804-wj35q88f	180	7	such	such	JJ
cord-018804-wj35q88f	180	8	as	as	IN
cord-018804-wj35q88f	180	9	HIV	HIV	NNP
cord-018804-wj35q88f	180	10	and	and	CC
cord-018804-wj35q88f	180	11	HCV	HCV	NNP
cord-018804-wj35q88f	180	12	(	(	-LRB-
cord-018804-wj35q88f	180	13	hepatitis	hepatitis	NN
cord-018804-wj35q88f	180	14	C	C	NNP
cord-018804-wj35q88f	180	15	virus	virus	NN
cord-018804-wj35q88f	180	16	)	)	-RRB-
cord-018804-wj35q88f	180	17	that	that	WDT
cord-018804-wj35q88f	180	18	can	can	MD
cord-018804-wj35q88f	180	19	persist	persist	VB
cord-018804-wj35q88f	180	20	in	in	IN
cord-018804-wj35q88f	180	21	their	-PRON-	PRP$
cord-018804-wj35q88f	180	22	host	host	NN
cord-018804-wj35q88f	180	23	during	during	IN
cord-018804-wj35q88f	180	24	long	long	JJ
cord-018804-wj35q88f	180	25	times	time	NNS
cord-018804-wj35q88f	180	26	periods	period	NNS
cord-018804-wj35q88f	180	27	.	.	.
cord-018804-wj35q88f	181	1	For	for	IN
cord-018804-wj35q88f	181	2	these	these	DT
cord-018804-wj35q88f	181	3	viruses	virus	NNS
cord-018804-wj35q88f	181	4	,	,	,
cord-018804-wj35q88f	181	5	inter	inter	JJ
cord-018804-wj35q88f	181	6	-	-	JJ
cord-018804-wj35q88f	181	7	host	host	JJ
cord-018804-wj35q88f	181	8	dynamics	dynamic	NNS
cord-018804-wj35q88f	181	9	is	be	VBZ
cord-018804-wj35q88f	181	10	slow	slow	JJ
cord-018804-wj35q88f	181	11	,	,	,
cord-018804-wj35q88f	181	12	being	be	VBG
cord-018804-wj35q88f	181	13	more	more	RBR
cord-018804-wj35q88f	181	14	important	important	JJ
cord-018804-wj35q88f	181	15	and	and	CC
cord-018804-wj35q88f	181	16	faster	fast	RBR
cord-018804-wj35q88f	181	17	the	the	DT
cord-018804-wj35q88f	181	18	intra	intra	JJ
cord-018804-wj35q88f	181	19	-	-	JJ
cord-018804-wj35q88f	181	20	host	host	JJ
cord-018804-wj35q88f	181	21	period	period	NN
cord-018804-wj35q88f	181	22	of	of	IN
cord-018804-wj35q88f	181	23	evolution	evolution	NN
cord-018804-wj35q88f	181	24	that	that	WDT
cord-018804-wj35q88f	181	25	is	be	VBZ
cord-018804-wj35q88f	181	26	driven	drive	VBN
cord-018804-wj35q88f	181	27	by	by	IN
cord-018804-wj35q88f	181	28	continuous	continuous	JJ
cord-018804-wj35q88f	181	29	and	and	CC
cord-018804-wj35q88f	181	30	strong	strong	JJ
cord-018804-wj35q88f	181	31	immune	immune	JJ
cord-018804-wj35q88f	181	32	pressure	pressure	NN
cord-018804-wj35q88f	181	33	.	.	.
cord-018804-wj35q88f	182	1	Since	since	IN
cord-018804-wj35q88f	182	2	the	the	DT
cord-018804-wj35q88f	182	3	high	high	JJ
cord-018804-wj35q88f	182	4	genetic	genetic	JJ
cord-018804-wj35q88f	182	5	heterogeneity	heterogeneity	NN
cord-018804-wj35q88f	182	6	of	of	IN
cord-018804-wj35q88f	182	7	RNA	RNA	NNP
cord-018804-wj35q88f	182	8	viruses	virus	NNS
cord-018804-wj35q88f	182	9	provides	provide	VBZ
cord-018804-wj35q88f	182	10	an	an	DT
cord-018804-wj35q88f	182	11	enormous	enormous	JJ
cord-018804-wj35q88f	182	12	adaptive	adaptive	JJ
cord-018804-wj35q88f	182	13	capacity	capacity	NN
cord-018804-wj35q88f	182	14	,	,	,
cord-018804-wj35q88f	182	15	it	-PRON-	PRP
cord-018804-wj35q88f	182	16	could	could	MD
cord-018804-wj35q88f	182	17	be	be	VB
cord-018804-wj35q88f	182	18	naively	naively	RB
cord-018804-wj35q88f	182	19	expected	expect	VBN
cord-018804-wj35q88f	182	20	that	that	IN
cord-018804-wj35q88f	182	21	additional	additional	JJ
cord-018804-wj35q88f	182	22	increases	increase	NNS
cord-018804-wj35q88f	182	23	in	in	IN
cord-018804-wj35q88f	182	24	the	the	DT
cord-018804-wj35q88f	182	25	replication	replication	NN
cord-018804-wj35q88f	182	26	error	error	NN
cord-018804-wj35q88f	182	27	rate	rate	NN
cord-018804-wj35q88f	182	28	makes	make	VBZ
cord-018804-wj35q88f	182	29	evolutionary	evolutionary	JJ
cord-018804-wj35q88f	182	30	adaptation	adaptation	NN
cord-018804-wj35q88f	182	31	even	even	RB
cord-018804-wj35q88f	182	32	more	more	RBR
cord-018804-wj35q88f	182	33	efficient	efficient	JJ
cord-018804-wj35q88f	182	34	.	.	.
cord-018804-wj35q88f	183	1	However	however	RB
cord-018804-wj35q88f	183	2	,	,	,
cord-018804-wj35q88f	183	3	there	there	EX
cord-018804-wj35q88f	183	4	are	be	VBP
cord-018804-wj35q88f	183	5	many	many	JJ
cord-018804-wj35q88f	183	6	theoretical	theoretical	JJ
cord-018804-wj35q88f	183	7	and	and	CC
cord-018804-wj35q88f	183	8	experimental	experimental	JJ
cord-018804-wj35q88f	183	9	evidences	evidence	NNS
cord-018804-wj35q88f	183	10	showing	show	VBG
cord-018804-wj35q88f	183	11	that	that	IN
cord-018804-wj35q88f	183	12	RNA	RNA	NNP
cord-018804-wj35q88f	183	13	viruses	virus	NNS
cord-018804-wj35q88f	183	14	have	have	VBP
cord-018804-wj35q88f	183	15	selected	select	VBN
cord-018804-wj35q88f	183	16	the	the	DT
cord-018804-wj35q88f	183	17	maximal	maximal	JJ
cord-018804-wj35q88f	183	18	error	error	NN
cord-018804-wj35q88f	183	19	rate	rate	NN
cord-018804-wj35q88f	183	20	,	,	,
cord-018804-wj35q88f	183	21	which	which	WDT
cord-018804-wj35q88f	183	22	is	be	VBZ
cord-018804-wj35q88f	183	23	compatible	compatible	JJ
cord-018804-wj35q88f	183	24	with	with	IN
cord-018804-wj35q88f	183	25	the	the	DT
cord-018804-wj35q88f	183	26	preservation	preservation	NN
cord-018804-wj35q88f	183	27	of	of	IN
cord-018804-wj35q88f	183	28	their	-PRON-	PRP$
cord-018804-wj35q88f	183	29	genetic	genetic	JJ
cord-018804-wj35q88f	183	30	information	information	NN
cord-018804-wj35q88f	183	31	.	.	.
cord-018804-wj35q88f	184	1	Theoretical	theoretical	JJ
cord-018804-wj35q88f	184	2	studies	study	NNS
cord-018804-wj35q88f	184	3	on	on	IN
cord-018804-wj35q88f	184	4	molecular	molecular	JJ
cord-018804-wj35q88f	184	5	evolution	evolution	NN
cord-018804-wj35q88f	184	6	postulate	postulate	VBP
cord-018804-wj35q88f	184	7	that	that	IN
cord-018804-wj35q88f	184	8	the	the	DT
cord-018804-wj35q88f	184	9	higher	high	JJR
cord-018804-wj35q88f	184	10	the	the	DT
cord-018804-wj35q88f	184	11	error	error	NN
cord-018804-wj35q88f	184	12	rate	rate	NN
cord-018804-wj35q88f	184	13	and	and	CC
cord-018804-wj35q88f	184	14	the	the	DT
cord-018804-wj35q88f	184	15	genome	genome	NN
cord-018804-wj35q88f	184	16	length	length	NN
cord-018804-wj35q88f	184	17	,	,	,
cord-018804-wj35q88f	184	18	the	the	DT
cord-018804-wj35q88f	184	19	smaller	small	JJR
cord-018804-wj35q88f	184	20	is	be	VBZ
cord-018804-wj35q88f	184	21	the	the	DT
cord-018804-wj35q88f	184	22	probability	probability	NN
cord-018804-wj35q88f	184	23	of	of	IN
cord-018804-wj35q88f	184	24	obtaining	obtain	VBG
cord-018804-wj35q88f	184	25	a	a	DT
cord-018804-wj35q88f	184	26	progeny	progeny	NN
cord-018804-wj35q88f	184	27	identical	identical	JJ
cord-018804-wj35q88f	184	28	to	to	IN
cord-018804-wj35q88f	184	29	the	the	DT
cord-018804-wj35q88f	184	30	parental	parental	JJ
cord-018804-wj35q88f	184	31	genome	genome	NN
cord-018804-wj35q88f	184	32	and	and	CC
cord-018804-wj35q88f	184	33	to	to	TO
cord-018804-wj35q88f	184	34	conserve	conserve	VB
cord-018804-wj35q88f	184	35	the	the	DT
cord-018804-wj35q88f	184	36	master	master	NN
cord-018804-wj35q88f	184	37	sequence	sequence	NN
cord-018804-wj35q88f	184	38	in	in	IN
cord-018804-wj35q88f	184	39	the	the	DT
cord-018804-wj35q88f	184	40	population	population	NN
cord-018804-wj35q88f	184	41	[	[	-LRB-
cord-018804-wj35q88f	184	42	17	17	CD
cord-018804-wj35q88f	184	43	,	,	,
cord-018804-wj35q88f	184	44	19	19	CD
cord-018804-wj35q88f	184	45	]	]	-RRB-
cord-018804-wj35q88f	184	46	.	.	.
cord-018804-wj35q88f	185	1	There	there	EX
cord-018804-wj35q88f	185	2	is	be	VBZ
cord-018804-wj35q88f	185	3	a	a	DT
cord-018804-wj35q88f	185	4	sharp	sharp	JJ
cord-018804-wj35q88f	185	5	limit	limit	NN
cord-018804-wj35q88f	185	6	,	,	,
cord-018804-wj35q88f	185	7	called	call	VBN
cord-018804-wj35q88f	185	8	error	error	NN
cord-018804-wj35q88f	185	9	threshold	threshold	NN
cord-018804-wj35q88f	185	10	,	,	,
cord-018804-wj35q88f	185	11	which	which	WDT
cord-018804-wj35q88f	185	12	can	can	MD
cord-018804-wj35q88f	185	13	not	not	RB
cord-018804-wj35q88f	185	14	be	be	VB
cord-018804-wj35q88f	185	15	crossed	cross	VBN
cord-018804-wj35q88f	185	16	without	without	IN
cord-018804-wj35q88f	185	17	catastrophic	catastrophic	JJ
cord-018804-wj35q88f	185	18	consequences	consequence	NNS
cord-018804-wj35q88f	185	19	for	for	IN
cord-018804-wj35q88f	185	20	the	the	DT
cord-018804-wj35q88f	185	21	survival	survival	NN
cord-018804-wj35q88f	185	22	of	of	IN
cord-018804-wj35q88f	185	23	the	the	DT
cord-018804-wj35q88f	185	24	population	population	NN
cord-018804-wj35q88f	185	25	(	(	-LRB-
cord-018804-wj35q88f	185	26	see	see	VB
cord-018804-wj35q88f	185	27	the	the	DT
cord-018804-wj35q88f	185	28	chapter	chapter	NN
cord-018804-wj35q88f	185	29	by	by	IN
cord-018804-wj35q88f	185	30	Jain	Jain	NNP
cord-018804-wj35q88f	185	31	and	and	CC
cord-018804-wj35q88f	185	32	Krug	Krug	NNP
cord-018804-wj35q88f	185	33	in	in	IN
cord-018804-wj35q88f	185	34	this	this	DT
cord-018804-wj35q88f	185	35	book	book	NN
cord-018804-wj35q88f	185	36	)	)	-RRB-
cord-018804-wj35q88f	185	37	.	.	.
cord-018804-wj35q88f	186	1	Below	below	IN
cord-018804-wj35q88f	186	2	this	this	DT
cord-018804-wj35q88f	186	3	limit	limit	NN
cord-018804-wj35q88f	186	4	,	,	,
cord-018804-wj35q88f	186	5	the	the	DT
cord-018804-wj35q88f	186	6	quasi	quasi	JJ
cord-018804-wj35q88f	186	7	-	-	NNS
cord-018804-wj35q88f	186	8	species	specie	NNS
cord-018804-wj35q88f	186	9	can	can	MD
cord-018804-wj35q88f	186	10	maintain	maintain	VB
cord-018804-wj35q88f	186	11	a	a	DT
cord-018804-wj35q88f	186	12	large	large	JJ
cord-018804-wj35q88f	186	13	genetic	genetic	JJ
cord-018804-wj35q88f	186	14	variability	variability	NN
cord-018804-wj35q88f	186	15	from	from	IN
cord-018804-wj35q88f	186	16	which	which	WDT
cord-018804-wj35q88f	186	17	the	the	DT
cord-018804-wj35q88f	186	18	best	well	RBS
cord-018804-wj35q88f	186	19	adapted	adapt	VBN
cord-018804-wj35q88f	186	20	molecules	molecule	NNS
cord-018804-wj35q88f	186	21	are	be	VBP
cord-018804-wj35q88f	186	22	selected	select	VBN
cord-018804-wj35q88f	186	23	.	.	.
cord-018804-wj35q88f	187	1	When	when	WRB
cord-018804-wj35q88f	187	2	the	the	DT
cord-018804-wj35q88f	187	3	threshold	threshold	NN
cord-018804-wj35q88f	187	4	is	be	VBZ
cord-018804-wj35q88f	187	5	crossed	cross	VBN
cord-018804-wj35q88f	187	6	,	,	,
cord-018804-wj35q88f	187	7	the	the	DT
cord-018804-wj35q88f	187	8	dispersing	disperse	VBG
cord-018804-wj35q88f	187	9	force	force	NN
cord-018804-wj35q88f	187	10	of	of	IN
cord-018804-wj35q88f	187	11	mutation	mutation	NN
cord-018804-wj35q88f	187	12	can	can	MD
cord-018804-wj35q88f	187	13	not	not	RB
cord-018804-wj35q88f	187	14	be	be	VB
cord-018804-wj35q88f	187	15	compensated	compensate	VBN
cord-018804-wj35q88f	187	16	by	by	IN
cord-018804-wj35q88f	187	17	selection	selection	NN
cord-018804-wj35q88f	187	18	of	of	IN
cord-018804-wj35q88f	187	19	the	the	DT
cord-018804-wj35q88f	187	20	best	good	JJS
cord-018804-wj35q88f	187	21	adapted	adapt	VBN
cord-018804-wj35q88f	187	22	phenotypes	phenotype	NNS
cord-018804-wj35q88f	187	23	and	and	CC
cord-018804-wj35q88f	187	24	the	the	DT
cord-018804-wj35q88f	187	25	genetic	genetic	JJ
cord-018804-wj35q88f	187	26	information	information	NN
cord-018804-wj35q88f	187	27	melts	melt	VBZ
cord-018804-wj35q88f	187	28	away	away	RB
cord-018804-wj35q88f	187	29	in	in	IN
cord-018804-wj35q88f	187	30	a	a	DT
cord-018804-wj35q88f	187	31	process	process	NN
cord-018804-wj35q88f	187	32	with	with	IN
cord-018804-wj35q88f	187	33	the	the	DT
cord-018804-wj35q88f	187	34	physical	physical	JJ
cord-018804-wj35q88f	187	35	characteristics	characteristic	NNS
cord-018804-wj35q88f	187	36	of	of	IN
cord-018804-wj35q88f	187	37	a	a	DT
cord-018804-wj35q88f	187	38	first	first	JJ
cord-018804-wj35q88f	187	39	order	order	NN
cord-018804-wj35q88f	187	40	phase	phase	NN
cord-018804-wj35q88f	187	41	transition	transition	NN
cord-018804-wj35q88f	187	42	,	,	,
cord-018804-wj35q88f	187	43	as	as	IN
cord-018804-wj35q88f	187	44	the	the	DT
cord-018804-wj35q88f	187	45	melting	melting	NN
cord-018804-wj35q88f	187	46	of	of	IN
cord-018804-wj35q88f	187	47	a	a	DT
cord-018804-wj35q88f	187	48	solid	solid	NN
cord-018804-wj35q88f	187	49	.	.	.
cord-018804-wj35q88f	188	1	The	the	DT
cord-018804-wj35q88f	188	2	transition	transition	NN
cord-018804-wj35q88f	188	3	takes	take	VBZ
cord-018804-wj35q88f	188	4	place	place	NN
cord-018804-wj35q88f	188	5	in	in	IN
cord-018804-wj35q88f	188	6	an	an	DT
cord-018804-wj35q88f	188	7	'	'	``
cord-018804-wj35q88f	188	8	information	information	NN
cord-018804-wj35q88f	188	9	space	space	NN
cord-018804-wj35q88f	188	10	'	'	''
cord-018804-wj35q88f	188	11	that	that	WDT
cord-018804-wj35q88f	188	12	is	be	VBZ
cord-018804-wj35q88f	188	13	multidimensional	multidimensional	JJ
cord-018804-wj35q88f	188	14	,	,	,
cord-018804-wj35q88f	188	15	comprising	comprise	VBG
cord-018804-wj35q88f	188	16	4	4	CD
cord-018804-wj35q88f	188	17	N	n	CD
cord-018804-wj35q88f	188	18	sequences	sequence	NNS
cord-018804-wj35q88f	188	19	of	of	IN
cord-018804-wj35q88f	188	20	length	length	NN
cord-018804-wj35q88f	188	21	N	n	CD
cord-018804-wj35q88f	188	22	[	[	-LRB-
cord-018804-wj35q88f	188	23	38	38	CD
cord-018804-wj35q88f	188	24	]	]	-RRB-
cord-018804-wj35q88f	188	25	.	.	.
cord-018804-wj35q88f	189	1	The	the	DT
cord-018804-wj35q88f	189	2	error	error	NN
cord-018804-wj35q88f	189	3	rate	rate	NN
cord-018804-wj35q88f	189	4	that	that	WDT
cord-018804-wj35q88f	189	5	can	can	MD
cord-018804-wj35q88f	189	6	be	be	VB
cord-018804-wj35q88f	189	7	maintained	maintain	VBN
cord-018804-wj35q88f	189	8	is	be	VBZ
cord-018804-wj35q88f	189	9	related	relate	VBN
cord-018804-wj35q88f	189	10	to	to	IN
cord-018804-wj35q88f	189	11	the	the	DT
cord-018804-wj35q88f	189	12	genome	genome	NN
cord-018804-wj35q88f	189	13	length	length	NN
cord-018804-wj35q88f	189	14	according	accord	VBG
cord-018804-wj35q88f	189	15	to	to	IN
cord-018804-wj35q88f	189	16	this	this	DT
cord-018804-wj35q88f	189	17	relation	relation	NN
cord-018804-wj35q88f	189	18	:	:	:
cord-018804-wj35q88f	190	1	Here	here	RB
cord-018804-wj35q88f	190	2	N	N	NNP
cord-018804-wj35q88f	190	3	max	max	NNP
cord-018804-wj35q88f	190	4	is	be	VBZ
cord-018804-wj35q88f	190	5	the	the	DT
cord-018804-wj35q88f	190	6	maximal	maximal	JJ
cord-018804-wj35q88f	190	7	length	length	NN
cord-018804-wj35q88f	190	8	of	of	IN
cord-018804-wj35q88f	190	9	the	the	DT
cord-018804-wj35q88f	190	10	genome	genome	NN
cord-018804-wj35q88f	190	11	and	and	CC
cord-018804-wj35q88f	190	12	it	-PRON-	PRP
cord-018804-wj35q88f	190	13	is	be	VBZ
cord-018804-wj35q88f	190	14	inversely	inversely	RB
cord-018804-wj35q88f	190	15	proportional	proportional	JJ
cord-018804-wj35q88f	190	16	to	to	IN
cord-018804-wj35q88f	190	17	the	the	DT
cord-018804-wj35q88f	190	18	error	error	NN
cord-018804-wj35q88f	190	19	rate	rate	NN
cord-018804-wj35q88f	190	20	per	per	IN
cord-018804-wj35q88f	190	21	nucleotide	nucleotide	NN
cord-018804-wj35q88f	190	22	(	(	-LRB-
cord-018804-wj35q88f	190	23	1	1	CD
cord-018804-wj35q88f	190	24	−	−	NN
cord-018804-wj35q88f	190	25	q	q	NNP
cord-018804-wj35q88f	190	26	)	)	-RRB-
cord-018804-wj35q88f	190	27	.	.	.
cord-018804-wj35q88f	191	1	The	the	DT
cord-018804-wj35q88f	191	2	factor	factor	NN
cord-018804-wj35q88f	191	3	s	s	POS
cord-018804-wj35q88f	191	4	0	0	CD
cord-018804-wj35q88f	191	5	indicates	indicate	VBZ
cord-018804-wj35q88f	191	6	the	the	DT
cord-018804-wj35q88f	191	7	selective	selective	JJ
cord-018804-wj35q88f	191	8	advantage	advantage	NN
cord-018804-wj35q88f	191	9	of	of	IN
cord-018804-wj35q88f	191	10	the	the	DT
cord-018804-wj35q88f	191	11	master	master	NN
cord-018804-wj35q88f	191	12	sequence	sequence	NN
cord-018804-wj35q88f	191	13	in	in	IN
cord-018804-wj35q88f	191	14	relation	relation	NN
cord-018804-wj35q88f	191	15	to	to	IN
cord-018804-wj35q88f	191	16	the	the	DT
cord-018804-wj35q88f	191	17	mutant	mutant	JJ
cord-018804-wj35q88f	191	18	spectrum	spectrum	NN
cord-018804-wj35q88f	191	19	.	.	.
cord-018804-wj35q88f	192	1	Measurements	measurement	NNS
cord-018804-wj35q88f	192	2	of	of	IN
cord-018804-wj35q88f	192	3	the	the	DT
cord-018804-wj35q88f	192	4	chain	chain	NN
cord-018804-wj35q88f	192	5	lengths	length	NNS
cord-018804-wj35q88f	192	6	and	and	CC
cord-018804-wj35q88f	192	7	the	the	DT
cord-018804-wj35q88f	192	8	replication	replication	NN
cord-018804-wj35q88f	192	9	error	error	NN
cord-018804-wj35q88f	192	10	rates	rate	NNS
cord-018804-wj35q88f	192	11	of	of	IN
cord-018804-wj35q88f	192	12	RNA	RNA	NNP
cord-018804-wj35q88f	192	13	viruses	virus	NNS
cord-018804-wj35q88f	192	14	show	show	VBP
cord-018804-wj35q88f	192	15	that	that	IN
cord-018804-wj35q88f	192	16	the	the	DT
cord-018804-wj35q88f	192	17	genome	genome	NN
cord-018804-wj35q88f	192	18	lengths	length	NNS
cord-018804-wj35q88f	192	19	of	of	IN
cord-018804-wj35q88f	192	20	RNA	RNA	NNP
cord-018804-wj35q88f	192	21	viruses	virus	NNS
cord-018804-wj35q88f	192	22	are	be	VBP
cord-018804-wj35q88f	192	23	close	close	JJ
cord-018804-wj35q88f	192	24	to	to	IN
cord-018804-wj35q88f	192	25	the	the	DT
cord-018804-wj35q88f	192	26	maximum	maximum	NN
cord-018804-wj35q88f	192	27	that	that	WDT
cord-018804-wj35q88f	192	28	can	can	MD
cord-018804-wj35q88f	192	29	be	be	VB
cord-018804-wj35q88f	192	30	maintained	maintain	VBN
cord-018804-wj35q88f	192	31	at	at	IN
cord-018804-wj35q88f	192	32	the	the	DT
cord-018804-wj35q88f	192	33	error	error	NN
cord-018804-wj35q88f	192	34	rates	rate	NNS
cord-018804-wj35q88f	192	35	of	of	IN
cord-018804-wj35q88f	192	36	their	-PRON-	PRP$
cord-018804-wj35q88f	192	37	replication	replication	NN
cord-018804-wj35q88f	192	38	.	.	.
cord-018804-wj35q88f	193	1	Moreover	moreover	RB
cord-018804-wj35q88f	193	2	,	,	,
cord-018804-wj35q88f	193	3	phylogenetic	phylogenetic	JJ
cord-018804-wj35q88f	193	4	analysis	analysis	NN
cord-018804-wj35q88f	193	5	of	of	IN
cord-018804-wj35q88f	193	6	RNA	RNA	NNP
cord-018804-wj35q88f	193	7	viruses	virus	NNS
cord-018804-wj35q88f	193	8	reveals	reveal	VBZ
cord-018804-wj35q88f	193	9	a	a	DT
cord-018804-wj35q88f	193	10	negative	negative	JJ
cord-018804-wj35q88f	193	11	correlation	correlation	NN
cord-018804-wj35q88f	193	12	between	between	IN
cord-018804-wj35q88f	193	13	rates	rate	NNS
cord-018804-wj35q88f	193	14	of	of	IN
cord-018804-wj35q88f	193	15	nucleotide	nucleotide	JJ
cord-018804-wj35q88f	193	16	substitution	substitution	NN
cord-018804-wj35q88f	193	17	and	and	CC
cord-018804-wj35q88f	193	18	genome	genome	NN
cord-018804-wj35q88f	193	19	size	size	NN
cord-018804-wj35q88f	193	20	[	[	-LRB-
cord-018804-wj35q88f	193	21	39	39	CD
cord-018804-wj35q88f	193	22	]	]	-RRB-
cord-018804-wj35q88f	193	23	.	.	.
cord-018804-wj35q88f	194	1	As	as	IN
cord-018804-wj35q88f	194	2	a	a	DT
cord-018804-wj35q88f	194	3	direct	direct	JJ
cord-018804-wj35q88f	194	4	consequence	consequence	NN
cord-018804-wj35q88f	194	5	,	,	,
cord-018804-wj35q88f	194	6	all	all	DT
cord-018804-wj35q88f	194	7	viral	viral	JJ
cord-018804-wj35q88f	194	8	functions	function	NNS
cord-018804-wj35q88f	194	9	must	must	MD
cord-018804-wj35q88f	194	10	be	be	VB
cord-018804-wj35q88f	194	11	encoded	encode	VBN
cord-018804-wj35q88f	194	12	within	within	IN
cord-018804-wj35q88f	194	13	a	a	DT
cord-018804-wj35q88f	194	14	limited	limited	JJ
cord-018804-wj35q88f	194	15	genomic	genomic	JJ
cord-018804-wj35q88f	194	16	space	space	NN
cord-018804-wj35q88f	194	17	(	(	-LRB-
cord-018804-wj35q88f	194	18	10	10	CD
cord-018804-wj35q88f	194	19	-	-	SYM
cord-018804-wj35q88f	194	20	15	15	CD
cord-018804-wj35q88f	194	21	kb	kb	NNS
cord-018804-wj35q88f	194	22	on	on	IN
cord-018804-wj35q88f	194	23	average	average	NN
cord-018804-wj35q88f	194	24	for	for	IN
cord-018804-wj35q88f	194	25	most	most	JJS
cord-018804-wj35q88f	194	26	RNA	RNA	NNP
cord-018804-wj35q88f	194	27	viruses	virus	NNS
cord-018804-wj35q88f	194	28	)	)	-RRB-
cord-018804-wj35q88f	194	29	,	,	,
cord-018804-wj35q88f	194	30	meaning	mean	VBG
cord-018804-wj35q88f	194	31	that	that	IN
cord-018804-wj35q88f	194	32	certain	certain	JJ
cord-018804-wj35q88f	194	33	regions	region	NNS
cord-018804-wj35q88f	194	34	of	of	IN
cord-018804-wj35q88f	194	35	the	the	DT
cord-018804-wj35q88f	194	36	genome	genome	NN
cord-018804-wj35q88f	194	37	will	will	MD
cord-018804-wj35q88f	194	38	often	often	RB
cord-018804-wj35q88f	194	39	have	have	VB
cord-018804-wj35q88f	194	40	to	to	TO
cord-018804-wj35q88f	194	41	participate	participate	VB
cord-018804-wj35q88f	194	42	in	in	IN
cord-018804-wj35q88f	194	43	several	several	JJ
cord-018804-wj35q88f	194	44	functions	function	NNS
cord-018804-wj35q88f	194	45	at	at	IN
cord-018804-wj35q88f	194	46	the	the	DT
cord-018804-wj35q88f	194	47	same	same	JJ
cord-018804-wj35q88f	194	48	time	time	NN
cord-018804-wj35q88f	194	49	,	,	,
cord-018804-wj35q88f	194	50	resulting	result	VBG
cord-018804-wj35q88f	194	51	in	in	IN
cord-018804-wj35q88f	194	52	restrictions	restriction	NNS
cord-018804-wj35q88f	194	53	to	to	IN
cord-018804-wj35q88f	194	54	the	the	DT
cord-018804-wj35q88f	194	55	capacity	capacity	NN
cord-018804-wj35q88f	194	56	of	of	IN
cord-018804-wj35q88f	194	57	RNA	RNA	NNP
cord-018804-wj35q88f	194	58	virus	virus	NN
cord-018804-wj35q88f	194	59	to	to	TO
cord-018804-wj35q88f	194	60	alter	alter	VB
cord-018804-wj35q88f	194	61	their	-PRON-	PRP$
cord-018804-wj35q88f	194	62	nucleotide	nucleotide	JJ
cord-018804-wj35q88f	194	63	sequences	sequence	NNS
cord-018804-wj35q88f	194	64	.	.	.
cord-018804-wj35q88f	195	1	The	the	DT
cord-018804-wj35q88f	195	2	most	most	RBS
cord-018804-wj35q88f	195	3	frequent	frequent	JJ
cord-018804-wj35q88f	195	4	evolutionary	evolutionary	JJ
cord-018804-wj35q88f	195	5	constraints	constraint	NNS
cord-018804-wj35q88f	195	6	identified	identify	VBN
cord-018804-wj35q88f	195	7	are	be	VBP
cord-018804-wj35q88f	195	8	the	the	DT
cord-018804-wj35q88f	195	9	following	follow	VBG
cord-018804-wj35q88f	195	10	[	[	-LRB-
cord-018804-wj35q88f	195	11	22	22	CD
cord-018804-wj35q88f	195	12	]	]	-RRB-
cord-018804-wj35q88f	195	13	:	:	:
cord-018804-wj35q88f	195	14	1	1	LS
cord-018804-wj35q88f	195	15	.	.	.
cord-018804-wj35q88f	196	1	Usually	usually	RB
cord-018804-wj35q88f	196	2	,	,	,
cord-018804-wj35q88f	196	3	the	the	DT
cord-018804-wj35q88f	196	4	antigenic	antigenic	JJ
cord-018804-wj35q88f	196	5	determinants	determinant	NNS
cord-018804-wj35q88f	196	6	of	of	IN
cord-018804-wj35q88f	196	7	a	a	DT
cord-018804-wj35q88f	196	8	virus	virus	NN
cord-018804-wj35q88f	196	9	are	be	VBP
cord-018804-wj35q88f	196	10	domains	domain	NNS
cord-018804-wj35q88f	196	11	of	of	IN
cord-018804-wj35q88f	196	12	the	the	DT
cord-018804-wj35q88f	196	13	same	same	JJ
cord-018804-wj35q88f	196	14	proteins	protein	NNS
cord-018804-wj35q88f	196	15	involved	involve	VBN
cord-018804-wj35q88f	196	16	in	in	IN
cord-018804-wj35q88f	196	17	the	the	DT
cord-018804-wj35q88f	196	18	recognition	recognition	NN
cord-018804-wj35q88f	196	19	of	of	IN
cord-018804-wj35q88f	196	20	the	the	DT
cord-018804-wj35q88f	196	21	cellular	cellular	JJ
cord-018804-wj35q88f	196	22	receptor	receptor	NN
cord-018804-wj35q88f	196	23	[	[	-LRB-
cord-018804-wj35q88f	196	24	26	26	CD
cord-018804-wj35q88f	196	25	]	]	-RRB-
cord-018804-wj35q88f	196	26	.	.	.
cord-018804-wj35q88f	197	1	This	this	DT
cord-018804-wj35q88f	197	2	fact	fact	NN
cord-018804-wj35q88f	197	3	restricts	restrict	VBZ
cord-018804-wj35q88f	197	4	the	the	DT
cord-018804-wj35q88f	197	5	possibilities	possibility	NNS
cord-018804-wj35q88f	197	6	of	of	IN
cord-018804-wj35q88f	197	7	immune	immune	JJ
cord-018804-wj35q88f	197	8	escape	escape	NN
cord-018804-wj35q88f	197	9	to	to	IN
cord-018804-wj35q88f	197	10	the	the	DT
cord-018804-wj35q88f	197	11	occurrence	occurrence	NN
cord-018804-wj35q88f	197	12	of	of	IN
cord-018804-wj35q88f	197	13	mutations	mutation	NNS
cord-018804-wj35q88f	197	14	in	in	IN
cord-018804-wj35q88f	197	15	domains	domain	NNS
cord-018804-wj35q88f	197	16	that	that	WDT
cord-018804-wj35q88f	197	17	are	be	VBP
cord-018804-wj35q88f	197	18	not	not	RB
cord-018804-wj35q88f	197	19	crucial	crucial	JJ
cord-018804-wj35q88f	197	20	for	for	IN
cord-018804-wj35q88f	197	21	penetration	penetration	NN
cord-018804-wj35q88f	197	22	of	of	IN
cord-018804-wj35q88f	197	23	the	the	DT
cord-018804-wj35q88f	197	24	virus	virus	NN
cord-018804-wj35q88f	197	25	inside	inside	IN
cord-018804-wj35q88f	197	26	the	the	DT
cord-018804-wj35q88f	197	27	cell	cell	NN
cord-018804-wj35q88f	197	28	.	.	.
cord-018804-wj35q88f	198	1	2	2	LS
cord-018804-wj35q88f	198	2	.	.	.
cord-018804-wj35q88f	199	1	Genomic	genomic	JJ
cord-018804-wj35q88f	199	2	coding	coding	NN
cord-018804-wj35q88f	199	3	regions	region	NNS
cord-018804-wj35q88f	199	4	can	can	MD
cord-018804-wj35q88f	199	5	also	also	RB
cord-018804-wj35q88f	199	6	be	be	VB
cord-018804-wj35q88f	199	7	involved	involve	VBN
cord-018804-wj35q88f	199	8	in	in	IN
cord-018804-wj35q88f	199	9	the	the	DT
cord-018804-wj35q88f	199	10	interaction	interaction	NN
cord-018804-wj35q88f	199	11	with	with	IN
cord-018804-wj35q88f	199	12	enzymes	enzyme	NNS
cord-018804-wj35q88f	199	13	or	or	CC
cord-018804-wj35q88f	199	14	cellular	cellular	JJ
cord-018804-wj35q88f	199	15	structures	structure	NNS
cord-018804-wj35q88f	199	16	and	and	CC
cord-018804-wj35q88f	199	17	in	in	IN
cord-018804-wj35q88f	199	18	the	the	DT
cord-018804-wj35q88f	199	19	regulation	regulation	NN
cord-018804-wj35q88f	199	20	of	of	IN
cord-018804-wj35q88f	199	21	the	the	DT
cord-018804-wj35q88f	199	22	correct	correct	JJ
cord-018804-wj35q88f	199	23	synthesis	synthesis	NN
cord-018804-wj35q88f	199	24	and	and	CC
cord-018804-wj35q88f	199	25	assembly	assembly	NN
cord-018804-wj35q88f	199	26	of	of	IN
cord-018804-wj35q88f	199	27	the	the	DT
cord-018804-wj35q88f	199	28	viral	viral	JJ
cord-018804-wj35q88f	199	29	components	component	NNS
cord-018804-wj35q88f	199	30	to	to	TO
cord-018804-wj35q88f	199	31	constitute	constitute	VB
cord-018804-wj35q88f	199	32	mature	mature	JJ
cord-018804-wj35q88f	199	33	particles	particle	NNS
cord-018804-wj35q88f	199	34	.	.	.
cord-018804-wj35q88f	200	1	3	3	LS
cord-018804-wj35q88f	200	2	.	.	.
cord-018804-wj35q88f	201	1	Synonymous	synonymous	JJ
cord-018804-wj35q88f	201	2	mutations	mutation	NNS
cord-018804-wj35q88f	201	3	may	may	MD
cord-018804-wj35q88f	201	4	be	be	VB
cord-018804-wj35q88f	201	5	not	not	RB
cord-018804-wj35q88f	201	6	silent	silent	JJ
cord-018804-wj35q88f	201	7	and	and	CC
cord-018804-wj35q88f	201	8	have	have	VBP
cord-018804-wj35q88f	201	9	effect	effect	NN
cord-018804-wj35q88f	201	10	on	on	IN
cord-018804-wj35q88f	201	11	fitness	fitness	NN
cord-018804-wj35q88f	201	12	because	because	IN
cord-018804-wj35q88f	201	13	they	-PRON-	PRP
cord-018804-wj35q88f	201	14	can	can	MD
cord-018804-wj35q88f	201	15	affect	affect	VB
cord-018804-wj35q88f	201	16	the	the	DT
cord-018804-wj35q88f	201	17	secondary	secondary	JJ
cord-018804-wj35q88f	201	18	structure	structure	NN
cord-018804-wj35q88f	201	19	of	of	IN
cord-018804-wj35q88f	201	20	RNA	RNA	NNP
cord-018804-wj35q88f	201	21	domains	domain	NNS
cord-018804-wj35q88f	201	22	critical	critical	JJ
cord-018804-wj35q88f	201	23	for	for	IN
cord-018804-wj35q88f	201	24	keeping	keep	VBG
cord-018804-wj35q88f	201	25	the	the	DT
cord-018804-wj35q88f	201	26	stability	stability	NN
cord-018804-wj35q88f	201	27	and	and	CC
cord-018804-wj35q88f	201	28	functionality	functionality	NN
cord-018804-wj35q88f	201	29	of	of	IN
cord-018804-wj35q88f	201	30	the	the	DT
cord-018804-wj35q88f	201	31	molecule	molecule	NN
cord-018804-wj35q88f	201	32	[	[	-LRB-
cord-018804-wj35q88f	201	33	40	40	CD
cord-018804-wj35q88f	201	34	]	]	-RRB-
cord-018804-wj35q88f	201	35	.	.	.
cord-018804-wj35q88f	202	1	4	4	LS
cord-018804-wj35q88f	202	2	.	.	.
cord-018804-wj35q88f	203	1	Sometimes	sometimes	RB
cord-018804-wj35q88f	203	2	the	the	DT
cord-018804-wj35q88f	203	3	same	same	JJ
cord-018804-wj35q88f	203	4	genomic	genomic	JJ
cord-018804-wj35q88f	203	5	region	region	NN
cord-018804-wj35q88f	203	6	can	can	MD
cord-018804-wj35q88f	203	7	encode	encode	VB
cord-018804-wj35q88f	203	8	several	several	JJ
cord-018804-wj35q88f	203	9	proteins	protein	NNS
cord-018804-wj35q88f	203	10	through	through	IN
cord-018804-wj35q88f	203	11	the	the	DT
cord-018804-wj35q88f	203	12	use	use	NN
cord-018804-wj35q88f	203	13	of	of	IN
cord-018804-wj35q88f	203	14	overlapping	overlap	VBG
cord-018804-wj35q88f	203	15	reading	reading	NN
cord-018804-wj35q88f	203	16	frames	frame	NNS
cord-018804-wj35q88f	203	17	.	.	.
cord-018804-wj35q88f	204	1	In	in	IN
cord-018804-wj35q88f	204	2	most	most	JJS
cord-018804-wj35q88f	204	3	RNA	RNA	NNP
cord-018804-wj35q88f	204	4	viruses	virus	NNS
cord-018804-wj35q88f	204	5	,	,	,
cord-018804-wj35q88f	204	6	a	a	DT
cord-018804-wj35q88f	204	7	high	high	JJ
cord-018804-wj35q88f	204	8	amount	amount	NN
cord-018804-wj35q88f	204	9	of	of	IN
cord-018804-wj35q88f	204	10	particles	particle	NNS
cord-018804-wj35q88f	204	11	is	be	VBZ
cord-018804-wj35q88f	204	12	not	not	RB
cord-018804-wj35q88f	204	13	infectious	infectious	JJ
cord-018804-wj35q88f	204	14	,	,	,
cord-018804-wj35q88f	204	15	suggesting	suggest	VBG
cord-018804-wj35q88f	204	16	that	that	IN
cord-018804-wj35q88f	204	17	viral	viral	JJ
cord-018804-wj35q88f	204	18	populations	population	NNS
cord-018804-wj35q88f	204	19	operate	operate	VBP
cord-018804-wj35q88f	204	20	near	near	IN
cord-018804-wj35q88f	204	21	the	the	DT
cord-018804-wj35q88f	204	22	error	error	NN
cord-018804-wj35q88f	204	23	threshold	threshold	NN
cord-018804-wj35q88f	204	24	and	and	CC
cord-018804-wj35q88f	204	25	most	most	JJS
cord-018804-wj35q88f	204	26	mutations	mutation	NNS
cord-018804-wj35q88f	204	27	are	be	VBP
cord-018804-wj35q88f	204	28	not	not	RB
cord-018804-wj35q88f	204	29	easily	easily	RB
cord-018804-wj35q88f	204	30	tolerated	tolerate	VBN
cord-018804-wj35q88f	204	31	,	,	,
cord-018804-wj35q88f	204	32	possibly	possibly	RB
cord-018804-wj35q88f	204	33	due	due	IN
cord-018804-wj35q88f	204	34	to	to	IN
cord-018804-wj35q88f	204	35	the	the	DT
cord-018804-wj35q88f	204	36	above	above	RB
cord-018804-wj35q88f	204	37	-	-	HYPH
cord-018804-wj35q88f	204	38	mentioned	mention	VBN
cord-018804-wj35q88f	204	39	constraints	constraint	NNS
cord-018804-wj35q88f	204	40	.	.	.
cord-018804-wj35q88f	205	1	The	the	DT
cord-018804-wj35q88f	205	2	large	large	JJ
cord-018804-wj35q88f	205	3	population	population	NN
cord-018804-wj35q88f	205	4	sizes	size	NNS
cord-018804-wj35q88f	205	5	constituted	constitute	VBN
cord-018804-wj35q88f	205	6	by	by	IN
cord-018804-wj35q88f	205	7	RNA	RNA	NNP
cord-018804-wj35q88f	205	8	viruses	virus	NNS
cord-018804-wj35q88f	205	9	seem	seem	VBP
cord-018804-wj35q88f	205	10	to	to	TO
cord-018804-wj35q88f	205	11	be	be	VB
cord-018804-wj35q88f	205	12	necessary	necessary	JJ
cord-018804-wj35q88f	205	13	to	to	TO
cord-018804-wj35q88f	205	14	avoid	avoid	VB
cord-018804-wj35q88f	205	15	stochastic	stochastic	JJ
cord-018804-wj35q88f	205	16	extinctions	extinction	NNS
cord-018804-wj35q88f	205	17	that	that	WDT
cord-018804-wj35q88f	205	18	could	could	MD
cord-018804-wj35q88f	205	19	happen	happen	VB
cord-018804-wj35q88f	205	20	due	due	IN
cord-018804-wj35q88f	205	21	to	to	IN
cord-018804-wj35q88f	205	22	the	the	DT
cord-018804-wj35q88f	205	23	generation	generation	NN
cord-018804-wj35q88f	205	24	of	of	IN
cord-018804-wj35q88f	205	25	many	many	JJ
cord-018804-wj35q88f	205	26	deleterious	deleterious	JJ
cord-018804-wj35q88f	205	27	mutants	mutant	NNS
cord-018804-wj35q88f	205	28	.	.	.
cord-018804-wj35q88f	206	1	Given	give	VBN
cord-018804-wj35q88f	206	2	the	the	DT
cord-018804-wj35q88f	206	3	high	high	JJ
cord-018804-wj35q88f	206	4	mutation	mutation	NN
cord-018804-wj35q88f	206	5	rate	rate	NN
cord-018804-wj35q88f	206	6	of	of	IN
cord-018804-wj35q88f	206	7	RNA	RNA	NNP
cord-018804-wj35q88f	206	8	viruses	virus	NNS
cord-018804-wj35q88f	206	9	,	,	,
cord-018804-wj35q88f	206	10	and	and	CC
cord-018804-wj35q88f	206	11	the	the	DT
cord-018804-wj35q88f	206	12	increased	increase	VBN
cord-018804-wj35q88f	206	13	fraction	fraction	NN
cord-018804-wj35q88f	206	14	of	of	IN
cord-018804-wj35q88f	206	15	deleterious	deleterious	JJ
cord-018804-wj35q88f	206	16	mutations	mutation	NNS
cord-018804-wj35q88f	206	17	over	over	IN
cord-018804-wj35q88f	206	18	advantageous	advantageous	JJ
cord-018804-wj35q88f	206	19	ones	one	NNS
cord-018804-wj35q88f	206	20	that	that	WDT
cord-018804-wj35q88f	206	21	occur	occur	VBP
cord-018804-wj35q88f	206	22	when	when	WRB
cord-018804-wj35q88f	206	23	a	a	DT
cord-018804-wj35q88f	206	24	population	population	NN
cord-018804-wj35q88f	206	25	is	be	VBZ
cord-018804-wj35q88f	206	26	well	well	RB
cord-018804-wj35q88f	206	27	adapted	adapt	VBN
cord-018804-wj35q88f	206	28	to	to	IN
cord-018804-wj35q88f	206	29	the	the	DT
cord-018804-wj35q88f	206	30	environment	environment	NN
cord-018804-wj35q88f	206	31	,	,	,
cord-018804-wj35q88f	206	32	one	one	PRP
cord-018804-wj35q88f	206	33	can	can	MD
cord-018804-wj35q88f	206	34	think	think	VB
cord-018804-wj35q88f	206	35	of	of	IN
cord-018804-wj35q88f	206	36	two	two	CD
cord-018804-wj35q88f	206	37	alternative	alternative	JJ
cord-018804-wj35q88f	206	38	strategies	strategy	NNS
cord-018804-wj35q88f	206	39	for	for	IN
cord-018804-wj35q88f	206	40	driving	drive	VBG
cord-018804-wj35q88f	206	41	a	a	DT
cord-018804-wj35q88f	206	42	viral	viral	JJ
cord-018804-wj35q88f	206	43	population	population	NN
cord-018804-wj35q88f	206	44	to	to	IN
cord-018804-wj35q88f	206	45	extinction	extinction	NN
cord-018804-wj35q88f	206	46	.	.	.
cord-018804-wj35q88f	207	1	Both	both	DT
cord-018804-wj35q88f	207	2	of	of	IN
cord-018804-wj35q88f	207	3	them	-PRON-	PRP
cord-018804-wj35q88f	207	4	involve	involve	VBP
cord-018804-wj35q88f	207	5	an	an	DT
cord-018804-wj35q88f	207	6	increase	increase	NN
cord-018804-wj35q88f	207	7	in	in	IN
cord-018804-wj35q88f	207	8	the	the	DT
cord-018804-wj35q88f	207	9	number	number	NN
cord-018804-wj35q88f	207	10	of	of	IN
cord-018804-wj35q88f	207	11	mutations	mutation	NNS
cord-018804-wj35q88f	207	12	in	in	IN
cord-018804-wj35q88f	207	13	individual	individual	JJ
cord-018804-wj35q88f	207	14	viral	viral	JJ
cord-018804-wj35q88f	207	15	genomes	genome	NNS
cord-018804-wj35q88f	207	16	,	,	,
cord-018804-wj35q88f	207	17	which	which	WDT
cord-018804-wj35q88f	207	18	can	can	MD
cord-018804-wj35q88f	207	19	be	be	VB
cord-018804-wj35q88f	207	20	related	relate	VBN
cord-018804-wj35q88f	207	21	,	,	,
cord-018804-wj35q88f	207	22	although	although	IN
cord-018804-wj35q88f	207	23	not	not	RB
cord-018804-wj35q88f	207	24	necessarily	necessarily	RB
cord-018804-wj35q88f	207	25	,	,	,
cord-018804-wj35q88f	207	26	to	to	IN
cord-018804-wj35q88f	207	27	changes	change	NNS
cord-018804-wj35q88f	207	28	in	in	IN
cord-018804-wj35q88f	207	29	the	the	DT
cord-018804-wj35q88f	207	30	consensus	consensus	NN
cord-018804-wj35q88f	207	31	sequence	sequence	NN
cord-018804-wj35q88f	207	32	of	of	IN
cord-018804-wj35q88f	207	33	the	the	DT
cord-018804-wj35q88f	207	34	population	population	NN
cord-018804-wj35q88f	207	35	.	.	.
cord-018804-wj35q88f	208	1	The	the	DT
cord-018804-wj35q88f	208	2	first	first	JJ
cord-018804-wj35q88f	208	3	pathway	pathway	NN
cord-018804-wj35q88f	208	4	is	be	VBZ
cord-018804-wj35q88f	208	5	the	the	DT
cord-018804-wj35q88f	208	6	classical	classical	JJ
cord-018804-wj35q88f	208	7	one	one	NN
cord-018804-wj35q88f	208	8	described	describe	VBN
cord-018804-wj35q88f	208	9	by	by	IN
cord-018804-wj35q88f	208	10	molecular	molecular	JJ
cord-018804-wj35q88f	208	11	evolution	evolution	NN
cord-018804-wj35q88f	208	12	error	error	NN
cord-018804-wj35q88f	208	13	catastrophe	catastrophe	NN
cord-018804-wj35q88f	208	14	theories	theory	NNS
cord-018804-wj35q88f	208	15	.	.	.
cord-018804-wj35q88f	209	1	It	-PRON-	PRP
cord-018804-wj35q88f	209	2	consists	consist	VBZ
cord-018804-wj35q88f	209	3	in	in	IN
cord-018804-wj35q88f	209	4	the	the	DT
cord-018804-wj35q88f	209	5	increase	increase	NN
cord-018804-wj35q88f	209	6	of	of	IN
cord-018804-wj35q88f	209	7	the	the	DT
cord-018804-wj35q88f	209	8	replication	replication	NN
cord-018804-wj35q88f	209	9	error	error	NN
cord-018804-wj35q88f	209	10	rate	rate	NN
cord-018804-wj35q88f	209	11	,	,	,
cord-018804-wj35q88f	209	12	usually	usually	RB
cord-018804-wj35q88f	209	13	through	through	IN
cord-018804-wj35q88f	209	14	the	the	DT
cord-018804-wj35q88f	209	15	use	use	NN
cord-018804-wj35q88f	209	16	of	of	IN
cord-018804-wj35q88f	209	17	mutagens	mutagen	NNS
cord-018804-wj35q88f	209	18	.	.	.
cord-018804-wj35q88f	210	1	The	the	DT
cord-018804-wj35q88f	210	2	new	new	JJ
cord-018804-wj35q88f	210	3	populations	population	NNS
cord-018804-wj35q88f	210	4	generated	generate	VBN
cord-018804-wj35q88f	210	5	exhibit	exhibit	NN
cord-018804-wj35q88f	210	6	larger	large	JJR
cord-018804-wj35q88f	210	7	complexity	complexity	NN
cord-018804-wj35q88f	210	8	than	than	IN
cord-018804-wj35q88f	210	9	the	the	DT
cord-018804-wj35q88f	210	10	initial	initial	JJ
cord-018804-wj35q88f	210	11	ones	one	NNS
cord-018804-wj35q88f	210	12	.	.	.
cord-018804-wj35q88f	211	1	Advantageous	advantageous	JJ
cord-018804-wj35q88f	211	2	mutations	mutation	NNS
cord-018804-wj35q88f	211	3	,	,	,
cord-018804-wj35q88f	211	4	even	even	RB
cord-018804-wj35q88f	211	5	if	if	IN
cord-018804-wj35q88f	211	6	they	-PRON-	PRP
cord-018804-wj35q88f	211	7	occur	occur	VBP
cord-018804-wj35q88f	211	8	,	,	,
cord-018804-wj35q88f	211	9	would	would	MD
cord-018804-wj35q88f	211	10	be	be	VB
cord-018804-wj35q88f	211	11	spoiled	spoil	VBN
cord-018804-wj35q88f	211	12	by	by	IN
cord-018804-wj35q88f	211	13	the	the	DT
cord-018804-wj35q88f	211	14	continuous	continuous	JJ
cord-018804-wj35q88f	211	15	generation	generation	NN
cord-018804-wj35q88f	211	16	of	of	IN
cord-018804-wj35q88f	211	17	deleterious	deleterious	JJ
cord-018804-wj35q88f	211	18	mutations	mutation	NNS
cord-018804-wj35q88f	211	19	,	,	,
cord-018804-wj35q88f	211	20	before	before	IN
cord-018804-wj35q88f	211	21	they	-PRON-	PRP
cord-018804-wj35q88f	211	22	can	can	MD
cord-018804-wj35q88f	211	23	be	be	VB
cord-018804-wj35q88f	211	24	fixed	fix	VBN
cord-018804-wj35q88f	211	25	by	by	IN
cord-018804-wj35q88f	211	26	natural	natural	JJ
cord-018804-wj35q88f	211	27	selection	selection	NN
cord-018804-wj35q88f	211	28	.	.	.
cord-018804-wj35q88f	212	1	In	in	IN
cord-018804-wj35q88f	212	2	this	this	DT
cord-018804-wj35q88f	212	3	case	case	NN
cord-018804-wj35q88f	212	4	,	,	,
cord-018804-wj35q88f	212	5	it	-PRON-	PRP
cord-018804-wj35q88f	212	6	is	be	VBZ
cord-018804-wj35q88f	212	7	the	the	DT
cord-018804-wj35q88f	212	8	strong	strong	JJ
cord-018804-wj35q88f	212	9	dispersing	disperse	VBG
cord-018804-wj35q88f	212	10	force	force	NN
cord-018804-wj35q88f	212	11	of	of	IN
cord-018804-wj35q88f	212	12	mutation	mutation	NN
cord-018804-wj35q88f	212	13	what	what	WP
cord-018804-wj35q88f	212	14	dominates	dominate	VBZ
cord-018804-wj35q88f	212	15	the	the	DT
cord-018804-wj35q88f	212	16	dynamics	dynamic	NNS
cord-018804-wj35q88f	212	17	of	of	IN
cord-018804-wj35q88f	212	18	the	the	DT
cord-018804-wj35q88f	212	19	population	population	NN
cord-018804-wj35q88f	212	20	.	.	.
cord-018804-wj35q88f	213	1	The	the	DT
cord-018804-wj35q88f	213	2	second	second	JJ
cord-018804-wj35q88f	213	3	pathway	pathway	NN
cord-018804-wj35q88f	213	4	consists	consist	VBZ
cord-018804-wj35q88f	213	5	in	in	IN
cord-018804-wj35q88f	213	6	the	the	DT
cord-018804-wj35q88f	213	7	application	application	NN
cord-018804-wj35q88f	213	8	of	of	IN
cord-018804-wj35q88f	213	9	successive	successive	JJ
cord-018804-wj35q88f	213	10	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	213	11	to	to	IN
cord-018804-wj35q88f	213	12	the	the	DT
cord-018804-wj35q88f	213	13	population	population	NN
cord-018804-wj35q88f	213	14	.	.	.
cord-018804-wj35q88f	214	1	After	after	IN
cord-018804-wj35q88f	214	2	each	each	DT
cord-018804-wj35q88f	214	3	bottleneck	bottleneck	NN
cord-018804-wj35q88f	214	4	,	,	,
cord-018804-wj35q88f	214	5	the	the	DT
cord-018804-wj35q88f	214	6	founder	founder	NN
cord-018804-wj35q88f	214	7	genomes	genome	NNS
cord-018804-wj35q88f	214	8	give	give	VBP
cord-018804-wj35q88f	214	9	rise	rise	NN
cord-018804-wj35q88f	214	10	to	to	IN
cord-018804-wj35q88f	214	11	a	a	DT
cord-018804-wj35q88f	214	12	new	new	JJ
cord-018804-wj35q88f	214	13	population	population	NN
cord-018804-wj35q88f	214	14	through	through	IN
cord-018804-wj35q88f	214	15	a	a	DT
cord-018804-wj35q88f	214	16	limited	limited	JJ
cord-018804-wj35q88f	214	17	number	number	NN
cord-018804-wj35q88f	214	18	of	of	IN
cord-018804-wj35q88f	214	19	replication	replication	NN
cord-018804-wj35q88f	214	20	rounds	round	NNS
cord-018804-wj35q88f	214	21	.	.	.
cord-018804-wj35q88f	215	1	The	the	DT
cord-018804-wj35q88f	215	2	larger	large	JJR
cord-018804-wj35q88f	215	3	the	the	DT
cord-018804-wj35q88f	215	4	number	number	NN
cord-018804-wj35q88f	215	5	of	of	IN
cord-018804-wj35q88f	215	6	generations	generation	NNS
cord-018804-wj35q88f	215	7	between	between	IN
cord-018804-wj35q88f	215	8	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	215	9	,	,	,
cord-018804-wj35q88f	215	10	the	the	DT
cord-018804-wj35q88f	215	11	closer	close	JJR
cord-018804-wj35q88f	215	12	is	be	VBZ
cord-018804-wj35q88f	215	13	the	the	DT
cord-018804-wj35q88f	215	14	new	new	JJ
cord-018804-wj35q88f	215	15	population	population	NN
cord-018804-wj35q88f	215	16	to	to	IN
cord-018804-wj35q88f	215	17	the	the	DT
cord-018804-wj35q88f	215	18	equilibrium	equilibrium	NN
cord-018804-wj35q88f	215	19	between	between	IN
cord-018804-wj35q88f	215	20	mutation	mutation	NN
cord-018804-wj35q88f	215	21	and	and	CC
cord-018804-wj35q88f	215	22	selection	selection	NN
cord-018804-wj35q88f	215	23	[	[	-LRB-
cord-018804-wj35q88f	215	24	41	41	CD
cord-018804-wj35q88f	215	25	]	]	-RRB-
cord-018804-wj35q88f	215	26	.	.	.
cord-018804-wj35q88f	216	1	The	the	DT
cord-018804-wj35q88f	216	2	resulting	result	VBG
cord-018804-wj35q88f	216	3	populations	population	NNS
cord-018804-wj35q88f	216	4	have	have	VBP
cord-018804-wj35q88f	216	5	two	two	CD
cord-018804-wj35q88f	216	6	essential	essential	JJ
cord-018804-wj35q88f	216	7	characteristics	characteristic	NNS
cord-018804-wj35q88f	216	8	.	.	.
cord-018804-wj35q88f	217	1	The	the	DT
cord-018804-wj35q88f	217	2	first	first	JJ
cord-018804-wj35q88f	217	3	one	one	NN
cord-018804-wj35q88f	217	4	is	be	VBZ
cord-018804-wj35q88f	217	5	their	-PRON-	PRP$
cord-018804-wj35q88f	217	6	low	low	JJ
cord-018804-wj35q88f	217	7	complexity	complexity	NN
cord-018804-wj35q88f	217	8	,	,	,
cord-018804-wj35q88f	217	9	because	because	IN
cord-018804-wj35q88f	217	10	the	the	DT
cord-018804-wj35q88f	217	11	low	low	JJ
cord-018804-wj35q88f	217	12	number	number	NN
cord-018804-wj35q88f	217	13	of	of	IN
cord-018804-wj35q88f	217	14	copy	copy	NN
cord-018804-wj35q88f	217	15	rounds	round	NNS
cord-018804-wj35q88f	217	16	taking	take	VBG
cord-018804-wj35q88f	217	17	place	place	NN
cord-018804-wj35q88f	217	18	between	between	IN
cord-018804-wj35q88f	217	19	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	217	20	does	do	VBZ
cord-018804-wj35q88f	217	21	not	not	RB
cord-018804-wj35q88f	217	22	permit	permit	VB
cord-018804-wj35q88f	217	23	to	to	TO
cord-018804-wj35q88f	217	24	generate	generate	VB
cord-018804-wj35q88f	217	25	a	a	DT
cord-018804-wj35q88f	217	26	large	large	JJ
cord-018804-wj35q88f	217	27	genetic	genetic	JJ
cord-018804-wj35q88f	217	28	diversity	diversity	NN
cord-018804-wj35q88f	217	29	.	.	.
cord-018804-wj35q88f	218	1	The	the	DT
cord-018804-wj35q88f	218	2	second	second	JJ
cord-018804-wj35q88f	218	3	one	one	NN
cord-018804-wj35q88f	218	4	is	be	VBZ
cord-018804-wj35q88f	218	5	an	an	DT
cord-018804-wj35q88f	218	6	increased	increase	VBN
cord-018804-wj35q88f	218	7	rate	rate	NN
cord-018804-wj35q88f	218	8	in	in	IN
cord-018804-wj35q88f	218	9	the	the	DT
cord-018804-wj35q88f	218	10	fixation	fixation	NN
cord-018804-wj35q88f	218	11	of	of	IN
cord-018804-wj35q88f	218	12	mutations	mutation	NNS
cord-018804-wj35q88f	218	13	in	in	IN
cord-018804-wj35q88f	218	14	the	the	DT
cord-018804-wj35q88f	218	15	consensus	consensus	NN
cord-018804-wj35q88f	218	16	sequence	sequence	NN
cord-018804-wj35q88f	218	17	,	,	,
cord-018804-wj35q88f	218	18	since	since	IN
cord-018804-wj35q88f	218	19	most	most	JJS
cord-018804-wj35q88f	218	20	mutations	mutation	NNS
cord-018804-wj35q88f	218	21	present	present	JJ
cord-018804-wj35q88f	218	22	in	in	IN
cord-018804-wj35q88f	218	23	the	the	DT
cord-018804-wj35q88f	218	24	founder	founder	NN
cord-018804-wj35q88f	218	25	genomes	genome	NNS
cord-018804-wj35q88f	218	26	are	be	VBP
cord-018804-wj35q88f	218	27	transmitted	transmit	VBN
cord-018804-wj35q88f	218	28	to	to	IN
cord-018804-wj35q88f	218	29	the	the	DT
cord-018804-wj35q88f	218	30	descendants	descendant	NNS
cord-018804-wj35q88f	218	31	(	(	-LRB-
cord-018804-wj35q88f	218	32	Fig	fig	NN
cord-018804-wj35q88f	218	33	.	.	.
cord-018804-wj35q88f	218	34	15.1	15.1	CD
cord-018804-wj35q88f	218	35	)	)	-RRB-
cord-018804-wj35q88f	218	36	.	.	.
cord-018804-wj35q88f	219	1	Given	give	VBN
cord-018804-wj35q88f	219	2	the	the	DT
cord-018804-wj35q88f	219	3	high	high	JJ
cord-018804-wj35q88f	219	4	amount	amount	NN
cord-018804-wj35q88f	219	5	of	of	IN
cord-018804-wj35q88f	219	6	deleterious	deleterious	JJ
cord-018804-wj35q88f	219	7	mutations	mutation	NNS
cord-018804-wj35q88f	219	8	,	,	,
cord-018804-wj35q88f	219	9	the	the	DT
cord-018804-wj35q88f	219	10	expected	expect	VBN
cord-018804-wj35q88f	219	11	result	result	NN
cord-018804-wj35q88f	219	12	of	of	IN
cord-018804-wj35q88f	219	13	their	-PRON-	PRP$
cord-018804-wj35q88f	219	14	accumulation	accumulation	NN
cord-018804-wj35q88f	219	15	is	be	VBZ
cord-018804-wj35q88f	219	16	a	a	DT
cord-018804-wj35q88f	219	17	progressive	progressive	JJ
cord-018804-wj35q88f	219	18	reduction	reduction	NN
cord-018804-wj35q88f	219	19	in	in	IN
cord-018804-wj35q88f	219	20	the	the	DT
cord-018804-wj35q88f	219	21	average	average	JJ
cord-018804-wj35q88f	219	22	fitness	fitness	NN
cord-018804-wj35q88f	219	23	of	of	IN
cord-018804-wj35q88f	219	24	the	the	DT
cord-018804-wj35q88f	219	25	population	population	NN
cord-018804-wj35q88f	219	26	that	that	WDT
cord-018804-wj35q88f	219	27	could	could	MD
cord-018804-wj35q88f	219	28	lead	lead	VB
cord-018804-wj35q88f	219	29	to	to	IN
cord-018804-wj35q88f	219	30	the	the	DT
cord-018804-wj35q88f	219	31	extinction	extinction	NN
cord-018804-wj35q88f	219	32	of	of	IN
cord-018804-wj35q88f	219	33	infectivity	infectivity	NN
cord-018804-wj35q88f	219	34	.	.	.
cord-018804-wj35q88f	220	1	The	the	DT
cord-018804-wj35q88f	220	2	structure	structure	NN
cord-018804-wj35q88f	220	3	of	of	IN
cord-018804-wj35q88f	220	4	the	the	DT
cord-018804-wj35q88f	220	5	viral	viral	JJ
cord-018804-wj35q88f	220	6	populations	population	NNS
cord-018804-wj35q88f	220	7	generated	generate	VBN
cord-018804-wj35q88f	220	8	through	through	IN
cord-018804-wj35q88f	220	9	the	the	DT
cord-018804-wj35q88f	220	10	two	two	CD
cord-018804-wj35q88f	220	11	pathways	pathway	NNS
cord-018804-wj35q88f	220	12	described	describe	VBN
cord-018804-wj35q88f	220	13	here	here	RB
cord-018804-wj35q88f	220	14	have	have	VBP
cord-018804-wj35q88f	220	15	different	different	JJ
cord-018804-wj35q88f	220	16	evolutionary	evolutionary	JJ
cord-018804-wj35q88f	220	17	consequences	consequence	NNS
cord-018804-wj35q88f	220	18	that	that	WDT
cord-018804-wj35q88f	220	19	have	have	VBP
cord-018804-wj35q88f	220	20	been	be	VBN
cord-018804-wj35q88f	220	21	explored	explore	VBN
cord-018804-wj35q88f	220	22	experimentally	experimentally	RB
cord-018804-wj35q88f	220	23	by	by	IN
cord-018804-wj35q88f	220	24	several	several	JJ
cord-018804-wj35q88f	220	25	groups	group	NNS
cord-018804-wj35q88f	220	26	.	.	.
cord-018804-wj35q88f	221	1	Next	next	JJ
cord-018804-wj35q88f	221	2	sections	section	NNS
cord-018804-wj35q88f	221	3	contain	contain	VBP
cord-018804-wj35q88f	221	4	a	a	DT
cord-018804-wj35q88f	221	5	review	review	NN
cord-018804-wj35q88f	221	6	of	of	IN
cord-018804-wj35q88f	221	7	the	the	DT
cord-018804-wj35q88f	221	8	main	main	JJ
cord-018804-wj35q88f	221	9	results	result	NNS
cord-018804-wj35q88f	221	10	published	publish	VBN
cord-018804-wj35q88f	221	11	in	in	IN
cord-018804-wj35q88f	221	12	this	this	DT
cord-018804-wj35q88f	221	13	field	field	NN
cord-018804-wj35q88f	221	14	.	.	.
cord-018804-wj35q88f	222	1	There	there	EX
cord-018804-wj35q88f	222	2	are	be	VBP
cord-018804-wj35q88f	222	3	many	many	JJ
cord-018804-wj35q88f	222	4	experimental	experimental	JJ
cord-018804-wj35q88f	222	5	evidences	evidence	NNS
cord-018804-wj35q88f	222	6	documenting	document	VBG
cord-018804-wj35q88f	222	7	extinction	extinction	NN
cord-018804-wj35q88f	222	8	of	of	IN
cord-018804-wj35q88f	222	9	RNA	RNA	NNP
cord-018804-wj35q88f	222	10	viruses	virus	NNS
cord-018804-wj35q88f	222	11	experiencing	experience	VBG
cord-018804-wj35q88f	222	12	an	an	DT
cord-018804-wj35q88f	222	13	increased	increase	VBN
cord-018804-wj35q88f	222	14	mutation	mutation	NN
cord-018804-wj35q88f	222	15	rate	rate	NN
cord-018804-wj35q88f	222	16	due	due	IN
cord-018804-wj35q88f	222	17	to	to	IN
cord-018804-wj35q88f	222	18	the	the	DT
cord-018804-wj35q88f	222	19	action	action	NN
cord-018804-wj35q88f	222	20	of	of	IN
cord-018804-wj35q88f	222	21	mutagens	mutagen	NNS
cord-018804-wj35q88f	222	22	[	[	-LRB-
cord-018804-wj35q88f	222	23	42	42	CD
cord-018804-wj35q88f	222	24	]	]	-RRB-
cord-018804-wj35q88f	222	25	[	[	-LRB-
cord-018804-wj35q88f	222	26	43	43	CD
cord-018804-wj35q88f	222	27	]	]	-RRB-
cord-018804-wj35q88f	222	28	[	[	-LRB-
cord-018804-wj35q88f	222	29	44	44	CD
cord-018804-wj35q88f	222	30	]	]	-RRB-
cord-018804-wj35q88f	222	31	[	[	-LRB-
cord-018804-wj35q88f	222	32	45	45	CD
cord-018804-wj35q88f	222	33	]	]	-RRB-
cord-018804-wj35q88f	222	34	[	[	-LRB-
cord-018804-wj35q88f	222	35	46	46	CD
cord-018804-wj35q88f	222	36	]	]	-RRB-
cord-018804-wj35q88f	222	37	[	[	-LRB-
cord-018804-wj35q88f	222	38	47	47	CD
cord-018804-wj35q88f	222	39	]	]	-RRB-
cord-018804-wj35q88f	222	40	.	.	.
cord-018804-wj35q88f	223	1	The	the	DT
cord-018804-wj35q88f	223	2	mutagens	mutagen	NNS
cord-018804-wj35q88f	223	3	most	most	RBS
cord-018804-wj35q88f	223	4	currently	currently	RB
cord-018804-wj35q88f	223	5	used	use	VBN
cord-018804-wj35q88f	223	6	are	be	VBP
cord-018804-wj35q88f	223	7	5-fluorouracil	5-fluorouracil	CD
cord-018804-wj35q88f	223	8	(	(	-LRB-
cord-018804-wj35q88f	223	9	FU	FU	NNP
cord-018804-wj35q88f	223	10	)	)	-RRB-
cord-018804-wj35q88f	223	11	,	,	,
cord-018804-wj35q88f	223	12	5-azacytidine	5-azacytidine	CD
cord-018804-wj35q88f	223	13	(	(	-LRB-
cord-018804-wj35q88f	223	14	AZC	AZC	NNP
cord-018804-wj35q88f	223	15	)	)	-RRB-
cord-018804-wj35q88f	223	16	,	,	,
cord-018804-wj35q88f	223	17	azidothymidine	azidothymidine	FW
cord-018804-wj35q88f	223	18	(	(	-LRB-
cord-018804-wj35q88f	223	19	AZT	AZT	NNP
cord-018804-wj35q88f	223	20	)	)	-RRB-
cord-018804-wj35q88f	223	21	,	,	,
cord-018804-wj35q88f	223	22	ribavirin	ribavirin	NN
cord-018804-wj35q88f	223	23	and	and	CC
cord-018804-wj35q88f	223	24	7-hydroxyurea	7-hydroxyurea	CD
cord-018804-wj35q88f	223	25	.	.	.
cord-018804-wj35q88f	224	1	Some	some	DT
cord-018804-wj35q88f	224	2	of	of	IN
cord-018804-wj35q88f	224	3	them	-PRON-	PRP
cord-018804-wj35q88f	224	4	are	be	VBP
cord-018804-wj35q88f	224	5	nucleoside	nucleoside	JJ
cord-018804-wj35q88f	224	6	analogues	analogue	NNS
cord-018804-wj35q88f	224	7	that	that	WDT
cord-018804-wj35q88f	224	8	,	,	,
cord-018804-wj35q88f	224	9	in	in	IN
cord-018804-wj35q88f	224	10	addition	addition	NN
cord-018804-wj35q88f	224	11	to	to	IN
cord-018804-wj35q88f	224	12	increasing	increase	VBG
cord-018804-wj35q88f	224	13	the	the	DT
cord-018804-wj35q88f	224	14	rate	rate	NN
cord-018804-wj35q88f	224	15	of	of	IN
cord-018804-wj35q88f	224	16	erroneous	erroneous	JJ
cord-018804-wj35q88f	224	17	incorporation	incorporation	NN
cord-018804-wj35q88f	224	18	of	of	IN
cord-018804-wj35q88f	224	19	nucleotides	nucleotide	NNS
cord-018804-wj35q88f	224	20	,	,	,
cord-018804-wj35q88f	224	21	can	can	MD
cord-018804-wj35q88f	224	22	also	also	RB
cord-018804-wj35q88f	224	23	interfere	interfere	VB
cord-018804-wj35q88f	224	24	with	with	IN
cord-018804-wj35q88f	224	25	other	other	JJ
cord-018804-wj35q88f	224	26	cellular	cellular	JJ
cord-018804-wj35q88f	224	27	or	or	CC
cord-018804-wj35q88f	224	28	viral	viral	JJ
cord-018804-wj35q88f	224	29	processes	process	NNS
cord-018804-wj35q88f	224	30	,	,	,
cord-018804-wj35q88f	224	31	such	such	JJ
cord-018804-wj35q88f	224	32	as	as	IN
cord-018804-wj35q88f	224	33	endogenous	endogenous	JJ
cord-018804-wj35q88f	224	34	nucleotide	nucleotide	JJ
cord-018804-wj35q88f	224	35	metabolism	metabolism	NN
cord-018804-wj35q88f	224	36	,	,	,
cord-018804-wj35q88f	224	37	viral	viral	JJ
cord-018804-wj35q88f	224	38	replication	replication	NN
cord-018804-wj35q88f	224	39	or	or	CC
cord-018804-wj35q88f	224	40	transcription	transcription	NN
cord-018804-wj35q88f	224	41	.	.	.
cord-018804-wj35q88f	225	1	Foot	foot	NN
cord-018804-wj35q88f	225	2	-	-	HYPH
cord-018804-wj35q88f	225	3	and	and	CC
cord-018804-wj35q88f	225	4	-	-	HYPH
cord-018804-wj35q88f	225	5	mouth	mouth	NN
cord-018804-wj35q88f	225	6	disease	disease	NN
cord-018804-wj35q88f	225	7	virus	virus	NN
cord-018804-wj35q88f	225	8	(	(	-LRB-
cord-018804-wj35q88f	225	9	FMDV	FMDV	NNP
cord-018804-wj35q88f	225	10	)	)	-RRB-
cord-018804-wj35q88f	225	11	,	,	,
cord-018804-wj35q88f	225	12	poliovirus	poliovirus	NN
cord-018804-wj35q88f	225	13	,	,	,
cord-018804-wj35q88f	225	14	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	225	15	and	and	CC
cord-018804-wj35q88f	225	16	lymphocytic	lymphocytic	JJ
cord-018804-wj35q88f	225	17	choriomeningitis	choriomeningitis	NNP
cord-018804-wj35q88f	225	18	virus	virus	NN
cord-018804-wj35q88f	225	19	(	(	-LRB-
cord-018804-wj35q88f	225	20	LCMV	LCMV	NNP
cord-018804-wj35q88f	225	21	)	)	-RRB-
cord-018804-wj35q88f	225	22	are	be	VBP
cord-018804-wj35q88f	225	23	some	some	DT
cord-018804-wj35q88f	225	24	examples	example	NNS
cord-018804-wj35q88f	225	25	of	of	IN
cord-018804-wj35q88f	225	26	RNA	RNA	NNP
cord-018804-wj35q88f	225	27	viruses	virus	NNS
cord-018804-wj35q88f	225	28	in	in	IN
cord-018804-wj35q88f	225	29	which	which	WDT
cord-018804-wj35q88f	225	30	successful	successful	JJ
cord-018804-wj35q88f	225	31	extinctions	extinction	NNS
cord-018804-wj35q88f	225	32	of	of	IN
cord-018804-wj35q88f	225	33	infectivity	infectivity	NN
cord-018804-wj35q88f	225	34	have	have	VBP
cord-018804-wj35q88f	225	35	been	be	VBN
cord-018804-wj35q88f	225	36	documented	document	VBN
cord-018804-wj35q88f	225	37	.	.	.
cord-018804-wj35q88f	226	1	The	the	DT
cord-018804-wj35q88f	226	2	results	result	NNS
cord-018804-wj35q88f	226	3	agree	agree	VBP
cord-018804-wj35q88f	226	4	with	with	IN
cord-018804-wj35q88f	226	5	molecular	molecular	JJ
cord-018804-wj35q88f	226	6	evolution	evolution	NN
cord-018804-wj35q88f	226	7	theories	theory	NNS
cord-018804-wj35q88f	226	8	that	that	WDT
cord-018804-wj35q88f	226	9	postulate	postulate	VBP
cord-018804-wj35q88f	226	10	that	that	IN
cord-018804-wj35q88f	226	11	viral	viral	JJ
cord-018804-wj35q88f	226	12	replication	replication	NN
cord-018804-wj35q88f	226	13	operates	operate	VBZ
cord-018804-wj35q88f	226	14	very	very	RB
cord-018804-wj35q88f	226	15	close	close	JJ
cord-018804-wj35q88f	226	16	to	to	IN
cord-018804-wj35q88f	226	17	an	an	DT
cord-018804-wj35q88f	226	18	error	error	NN
cord-018804-wj35q88f	226	19	threshold	threshold	NN
cord-018804-wj35q88f	226	20	that	that	WDT
cord-018804-wj35q88f	226	21	can	can	MD
cord-018804-wj35q88f	226	22	not	not	RB
cord-018804-wj35q88f	226	23	be	be	VB
cord-018804-wj35q88f	226	24	crossed	cross	VBN
cord-018804-wj35q88f	226	25	without	without	IN
cord-018804-wj35q88f	226	26	compromising	compromise	VBG
cord-018804-wj35q88f	226	27	the	the	DT
cord-018804-wj35q88f	226	28	transmission	transmission	NN
cord-018804-wj35q88f	226	29	of	of	IN
cord-018804-wj35q88f	226	30	genetic	genetic	JJ
cord-018804-wj35q88f	226	31	information	information	NN
cord-018804-wj35q88f	226	32	and	and	CC
cord-018804-wj35q88f	226	33	the	the	DT
cord-018804-wj35q88f	226	34	existence	existence	NN
cord-018804-wj35q88f	226	35	of	of	IN
cord-018804-wj35q88f	226	36	the	the	DT
cord-018804-wj35q88f	226	37	population	population	NN
cord-018804-wj35q88f	226	38	(	(	-LRB-
cord-018804-wj35q88f	226	39	reviewed	review	VBN
cord-018804-wj35q88f	226	40	in	in	IN
cord-018804-wj35q88f	226	41	[	[	-LRB-
cord-018804-wj35q88f	226	42	48	48	CD
cord-018804-wj35q88f	226	43	]	]	-RRB-
cord-018804-wj35q88f	226	44	)	)	-RRB-
cord-018804-wj35q88f	226	45	.	.	.
cord-018804-wj35q88f	227	1	Although	although	IN
cord-018804-wj35q88f	227	2	many	many	JJ
cord-018804-wj35q88f	227	3	studies	study	NNS
cord-018804-wj35q88f	227	4	have	have	VBP
cord-018804-wj35q88f	227	5	been	be	VBN
cord-018804-wj35q88f	227	6	devoted	devote	VBN
cord-018804-wj35q88f	227	7	to	to	IN
cord-018804-wj35q88f	227	8	the	the	DT
cord-018804-wj35q88f	227	9	characterization	characterization	NN
cord-018804-wj35q88f	227	10	of	of	IN
cord-018804-wj35q88f	227	11	the	the	DT
cord-018804-wj35q88f	227	12	mutant	mutant	JJ
cord-018804-wj35q88f	227	13	spectrum	spectrum	NN
cord-018804-wj35q88f	227	14	of	of	IN
cord-018804-wj35q88f	227	15	pre	pre	JJ
cord-018804-wj35q88f	227	16	-	-	JJ
cord-018804-wj35q88f	227	17	extinction	extinction	JJ
cord-018804-wj35q88f	227	18	populations	population	NNS
cord-018804-wj35q88f	227	19	[	[	-LRB-
cord-018804-wj35q88f	227	20	43	43	CD
cord-018804-wj35q88f	227	21	,	,	,
cord-018804-wj35q88f	227	22	49	49	CD
cord-018804-wj35q88f	227	23	,	,	,
cord-018804-wj35q88f	227	24	50	50	CD
cord-018804-wj35q88f	227	25	]	]	-RRB-
cord-018804-wj35q88f	227	26	,	,	,
cord-018804-wj35q88f	227	27	it	-PRON-	PRP
cord-018804-wj35q88f	227	28	is	be	VBZ
cord-018804-wj35q88f	227	29	not	not	RB
cord-018804-wj35q88f	227	30	clear	clear	JJ
cord-018804-wj35q88f	227	31	how	how	WRB
cord-018804-wj35q88f	227	32	the	the	DT
cord-018804-wj35q88f	227	33	quasi	quasi	JJ
cord-018804-wj35q88f	227	34	-	-	NNS
cord-018804-wj35q88f	227	35	species	species	JJ
cord-018804-wj35q88f	227	36	looses	loose	VBZ
cord-018804-wj35q88f	227	37	its	-PRON-	PRP$
cord-018804-wj35q88f	227	38	infective	infective	JJ
cord-018804-wj35q88f	227	39	capacity	capacity	NN
cord-018804-wj35q88f	227	40	.	.	.
cord-018804-wj35q88f	228	1	It	-PRON-	PRP
cord-018804-wj35q88f	228	2	is	be	VBZ
cord-018804-wj35q88f	228	3	not	not	RB
cord-018804-wj35q88f	228	4	known	know	VBN
cord-018804-wj35q88f	228	5	whether	whether	IN
cord-018804-wj35q88f	228	6	all	all	PDT
cord-018804-wj35q88f	228	7	the	the	DT
cord-018804-wj35q88f	228	8	genomes	genome	NNS
cord-018804-wj35q88f	228	9	are	be	VBP
cord-018804-wj35q88f	228	10	carrying	carry	VBG
cord-018804-wj35q88f	228	11	lethal	lethal	JJ
cord-018804-wj35q88f	228	12	mutations	mutation	NNS
cord-018804-wj35q88f	228	13	and	and	CC
cord-018804-wj35q88f	228	14	therefore	therefore	RB
cord-018804-wj35q88f	228	15	are	be	VBP
cord-018804-wj35q88f	228	16	unable	unable	JJ
cord-018804-wj35q88f	228	17	to	to	TO
cord-018804-wj35q88f	228	18	replicate	replicate	VB
cord-018804-wj35q88f	229	1	or	or	CC
cord-018804-wj35q88f	229	2	it	-PRON-	PRP
cord-018804-wj35q88f	229	3	is	be	VBZ
cord-018804-wj35q88f	229	4	the	the	DT
cord-018804-wj35q88f	229	5	disorganization	disorganization	NN
cord-018804-wj35q88f	229	6	of	of	IN
cord-018804-wj35q88f	229	7	the	the	DT
cord-018804-wj35q88f	229	8	mutant	mutant	JJ
cord-018804-wj35q88f	229	9	spectrum	spectrum	NN
cord-018804-wj35q88f	229	10	what	what	WP
cord-018804-wj35q88f	229	11	makes	make	VBZ
cord-018804-wj35q88f	229	12	the	the	DT
cord-018804-wj35q88f	229	13	quasi	quasi	JJ
cord-018804-wj35q88f	229	14	-	-	JJ
cord-018804-wj35q88f	229	15	species	specie	NNS
cord-018804-wj35q88f	229	16	to	to	TO
cord-018804-wj35q88f	229	17	be	be	VB
cord-018804-wj35q88f	229	18	non	non	JJ
cord-018804-wj35q88f	229	19	-	-	JJ
cord-018804-wj35q88f	229	20	infective	infective	JJ
cord-018804-wj35q88f	229	21	.	.	.
cord-018804-wj35q88f	230	1	In	in	IN
cord-018804-wj35q88f	230	2	the	the	DT
cord-018804-wj35q88f	230	3	last	last	JJ
cord-018804-wj35q88f	230	4	case	case	NN
cord-018804-wj35q88f	230	5	,	,	,
cord-018804-wj35q88f	230	6	the	the	DT
cord-018804-wj35q88f	230	7	quasispecies	quasispecie	NNS
cord-018804-wj35q88f	230	8	could	could	MD
cord-018804-wj35q88f	230	9	still	still	RB
cord-018804-wj35q88f	230	10	conserve	conserve	VB
cord-018804-wj35q88f	230	11	some	some	DT
cord-018804-wj35q88f	230	12	viable	viable	JJ
cord-018804-wj35q88f	230	13	genomes	genome	NNS
cord-018804-wj35q88f	230	14	that	that	WDT
cord-018804-wj35q88f	230	15	,	,	,
cord-018804-wj35q88f	230	16	in	in	IN
cord-018804-wj35q88f	230	17	the	the	DT
cord-018804-wj35q88f	230	18	absence	absence	NN
cord-018804-wj35q88f	230	19	of	of	IN
cord-018804-wj35q88f	230	20	the	the	DT
cord-018804-wj35q88f	230	21	interfering	interfere	VBG
cord-018804-wj35q88f	230	22	mutants	mutant	NNS
cord-018804-wj35q88f	230	23	,	,	,
cord-018804-wj35q88f	230	24	could	could	MD
cord-018804-wj35q88f	230	25	initiate	initiate	VB
cord-018804-wj35q88f	230	26	the	the	DT
cord-018804-wj35q88f	230	27	development	development	NN
cord-018804-wj35q88f	230	28	of	of	IN
cord-018804-wj35q88f	230	29	an	an	DT
cord-018804-wj35q88f	230	30	infective	infective	JJ
cord-018804-wj35q88f	230	31	population	population	NN
cord-018804-wj35q88f	230	32	.	.	.
cord-018804-wj35q88f	231	1	Mutagenized	mutagenized	JJ
cord-018804-wj35q88f	231	2	populations	population	NNS
cord-018804-wj35q88f	231	3	of	of	IN
cord-018804-wj35q88f	231	4	FMDV	FMDV	NNP
cord-018804-wj35q88f	231	5	treated	treat	VBN
cord-018804-wj35q88f	231	6	with	with	IN
cord-018804-wj35q88f	231	7	AZC	AZC	NNP
cord-018804-wj35q88f	231	8	and	and	CC
cord-018804-wj35q88f	231	9	FU	FU	NNP
cord-018804-wj35q88f	231	10	could	could	MD
cord-018804-wj35q88f	231	11	be	be	VB
cord-018804-wj35q88f	231	12	efficiently	efficiently	RB
cord-018804-wj35q88f	231	13	extinguished	extinguish	VBN
cord-018804-wj35q88f	231	14	[	[	-LRB-
cord-018804-wj35q88f	231	15	47	47	CD
cord-018804-wj35q88f	231	16	]	]	-RRB-
cord-018804-wj35q88f	231	17	.	.	.
cord-018804-wj35q88f	232	1	As	as	IN
cord-018804-wj35q88f	232	2	expected	expect	VBN
cord-018804-wj35q88f	232	3	,	,	,
cord-018804-wj35q88f	232	4	the	the	DT
cord-018804-wj35q88f	232	5	characterization	characterization	NN
cord-018804-wj35q88f	232	6	of	of	IN
cord-018804-wj35q88f	232	7	the	the	DT
cord-018804-wj35q88f	232	8	RNA	RNA	NNP
cord-018804-wj35q88f	232	9	genomes	genome	NNS
cord-018804-wj35q88f	232	10	composing	compose	VBG
cord-018804-wj35q88f	232	11	the	the	DT
cord-018804-wj35q88f	232	12	pre	pre	JJ
cord-018804-wj35q88f	232	13	-	-	JJ
cord-018804-wj35q88f	232	14	extinction	extinction	JJ
cord-018804-wj35q88f	232	15	populations	population	NNS
cord-018804-wj35q88f	232	16	did	do	VBD
cord-018804-wj35q88f	232	17	not	not	RB
cord-018804-wj35q88f	232	18	show	show	VB
cord-018804-wj35q88f	232	19	mutations	mutation	NNS
cord-018804-wj35q88f	232	20	in	in	IN
cord-018804-wj35q88f	232	21	the	the	DT
cord-018804-wj35q88f	232	22	consensus	consensus	NN
cord-018804-wj35q88f	232	23	sequences	sequence	NNS
cord-018804-wj35q88f	232	24	,	,	,
cord-018804-wj35q88f	232	25	but	but	CC
cord-018804-wj35q88f	232	26	displayed	display	VBD
cord-018804-wj35q88f	232	27	an	an	DT
cord-018804-wj35q88f	232	28	increase	increase	NN
cord-018804-wj35q88f	232	29	in	in	IN
cord-018804-wj35q88f	232	30	the	the	DT
cord-018804-wj35q88f	232	31	complexity	complexity	NN
cord-018804-wj35q88f	232	32	of	of	IN
cord-018804-wj35q88f	232	33	the	the	DT
cord-018804-wj35q88f	232	34	mutant	mutant	JJ
cord-018804-wj35q88f	232	35	spectrum	spectrum	NN
cord-018804-wj35q88f	232	36	(	(	-LRB-
cord-018804-wj35q88f	232	37	reviewed	review	VBN
cord-018804-wj35q88f	232	38	in	in	IN
cord-018804-wj35q88f	232	39	[	[	-LRB-
cord-018804-wj35q88f	232	40	51	51	CD
cord-018804-wj35q88f	232	41	]	]	-RRB-
cord-018804-wj35q88f	232	42	)	)	-RRB-
cord-018804-wj35q88f	232	43	.	.	.
cord-018804-wj35q88f	233	1	The	the	DT
cord-018804-wj35q88f	233	2	maximum	maximum	JJ
cord-018804-wj35q88f	233	3	increases	increase	NNS
cord-018804-wj35q88f	233	4	in	in	IN
cord-018804-wj35q88f	233	5	complexity	complexity	NN
cord-018804-wj35q88f	233	6	occurred	occur	VBD
cord-018804-wj35q88f	233	7	in	in	IN
cord-018804-wj35q88f	233	8	the	the	DT
cord-018804-wj35q88f	233	9	polymerase	polymerase	NN
cord-018804-wj35q88f	233	10	gene	gene	NN
cord-018804-wj35q88f	233	11	,	,	,
cord-018804-wj35q88f	233	12	which	which	WDT
cord-018804-wj35q88f	233	13	usually	usually	RB
cord-018804-wj35q88f	233	14	is	be	VBZ
cord-018804-wj35q88f	233	15	well	well	RB
cord-018804-wj35q88f	233	16	conserved	conserved	JJ
cord-018804-wj35q88f	233	17	.	.	.
cord-018804-wj35q88f	234	1	Other	other	JJ
cord-018804-wj35q88f	234	2	studies	study	NNS
cord-018804-wj35q88f	234	3	have	have	VBP
cord-018804-wj35q88f	234	4	also	also	RB
cord-018804-wj35q88f	234	5	demonstrated	demonstrate	VBN
cord-018804-wj35q88f	234	6	the	the	DT
cord-018804-wj35q88f	234	7	invariance	invariance	NN
cord-018804-wj35q88f	234	8	of	of	IN
cord-018804-wj35q88f	234	9	the	the	DT
cord-018804-wj35q88f	234	10	consensus	consensus	NN
cord-018804-wj35q88f	234	11	sequence	sequence	NN
cord-018804-wj35q88f	234	12	,	,	,
cord-018804-wj35q88f	234	13	despite	despite	IN
cord-018804-wj35q88f	234	14	the	the	DT
cord-018804-wj35q88f	234	15	occurrence	occurrence	NN
cord-018804-wj35q88f	234	16	of	of	IN
cord-018804-wj35q88f	234	17	a	a	DT
cord-018804-wj35q88f	234	18	high	high	JJ
cord-018804-wj35q88f	234	19	number	number	NN
cord-018804-wj35q88f	234	20	of	of	IN
cord-018804-wj35q88f	234	21	mutations	mutation	NNS
cord-018804-wj35q88f	234	22	in	in	IN
cord-018804-wj35q88f	234	23	individual	individual	JJ
cord-018804-wj35q88f	234	24	genomes	genome	NNS
cord-018804-wj35q88f	234	25	[	[	-LRB-
cord-018804-wj35q88f	234	26	43	43	CD
cord-018804-wj35q88f	234	27	]	]	-RRB-
cord-018804-wj35q88f	234	28	.	.	.
cord-018804-wj35q88f	235	1	The	the	DT
cord-018804-wj35q88f	235	2	same	same	JJ
cord-018804-wj35q88f	235	3	mutagenic	mutagenic	JJ
cord-018804-wj35q88f	235	4	agent	agent	NN
cord-018804-wj35q88f	235	5	can	can	MD
cord-018804-wj35q88f	235	6	behave	behave	VB
cord-018804-wj35q88f	235	7	differently	differently	RB
cord-018804-wj35q88f	235	8	in	in	IN
cord-018804-wj35q88f	235	9	different	different	JJ
cord-018804-wj35q88f	235	10	viruses	virus	NNS
cord-018804-wj35q88f	235	11	.	.	.
cord-018804-wj35q88f	236	1	As	as	IN
cord-018804-wj35q88f	236	2	an	an	DT
cord-018804-wj35q88f	236	3	example	example	NN
cord-018804-wj35q88f	236	4	,	,	,
cord-018804-wj35q88f	236	5	LCMV	LCMV	NNP
cord-018804-wj35q88f	236	6	was	be	VBD
cord-018804-wj35q88f	236	7	systematically	systematically	RB
cord-018804-wj35q88f	236	8	extinguished	extinguish	VBN
cord-018804-wj35q88f	236	9	after	after	IN
cord-018804-wj35q88f	236	10	only	only	RB
cord-018804-wj35q88f	236	11	two	two	CD
cord-018804-wj35q88f	236	12	or	or	CC
cord-018804-wj35q88f	236	13	three	three	CD
cord-018804-wj35q88f	236	14	passages	passage	NNS
cord-018804-wj35q88f	236	15	in	in	IN
cord-018804-wj35q88f	236	16	the	the	DT
cord-018804-wj35q88f	236	17	presence	presence	NN
cord-018804-wj35q88f	236	18	of	of	IN
cord-018804-wj35q88f	236	19	FU	FU	NNP
cord-018804-wj35q88f	236	20	[	[	-LRB-
cord-018804-wj35q88f	236	21	43	43	CD
cord-018804-wj35q88f	236	22	,	,	,
cord-018804-wj35q88f	236	23	52	52	CD
cord-018804-wj35q88f	236	24	]	]	-RRB-
cord-018804-wj35q88f	236	25	,	,	,
cord-018804-wj35q88f	236	26	whereas	whereas	IN
cord-018804-wj35q88f	236	27	extinction	extinction	NN
cord-018804-wj35q88f	236	28	of	of	IN
cord-018804-wj35q88f	236	29	FMDV	FMDV	NNP
cord-018804-wj35q88f	236	30	was	be	VBD
cord-018804-wj35q88f	236	31	stochastic	stochastic	JJ
cord-018804-wj35q88f	236	32	and	and	CC
cord-018804-wj35q88f	236	33	required	require	VBD
cord-018804-wj35q88f	236	34	a	a	DT
cord-018804-wj35q88f	236	35	larger	large	JJR
cord-018804-wj35q88f	236	36	number	number	NN
cord-018804-wj35q88f	236	37	of	of	IN
cord-018804-wj35q88f	236	38	passages	passage	NNS
cord-018804-wj35q88f	236	39	in	in	IN
cord-018804-wj35q88f	236	40	the	the	DT
cord-018804-wj35q88f	236	41	presence	presence	NN
cord-018804-wj35q88f	236	42	of	of	IN
cord-018804-wj35q88f	236	43	similar	similar	JJ
cord-018804-wj35q88f	236	44	amounts	amount	NNS
cord-018804-wj35q88f	236	45	of	of	IN
cord-018804-wj35q88f	236	46	mutagenic	mutagenic	JJ
cord-018804-wj35q88f	236	47	agent	agent	NN
cord-018804-wj35q88f	236	48	.	.	.
cord-018804-wj35q88f	237	1	Differences	difference	NNS
cord-018804-wj35q88f	237	2	in	in	IN
cord-018804-wj35q88f	237	3	the	the	DT
cord-018804-wj35q88f	237	4	susceptibility	susceptibility	NN
cord-018804-wj35q88f	237	5	of	of	IN
cord-018804-wj35q88f	237	6	a	a	DT
cord-018804-wj35q88f	237	7	virus	virus	NN
cord-018804-wj35q88f	237	8	to	to	IN
cord-018804-wj35q88f	237	9	a	a	DT
cord-018804-wj35q88f	237	10	mutagen	mutagen	NN
cord-018804-wj35q88f	237	11	can	can	MD
cord-018804-wj35q88f	237	12	be	be	VB
cord-018804-wj35q88f	237	13	explained	explain	VBN
cord-018804-wj35q88f	237	14	by	by	IN
cord-018804-wj35q88f	237	15	a	a	DT
cord-018804-wj35q88f	237	16	number	number	NN
cord-018804-wj35q88f	237	17	of	of	IN
cord-018804-wj35q88f	237	18	factors	factor	NNS
cord-018804-wj35q88f	237	19	including	include	VBG
cord-018804-wj35q88f	237	20	different	different	JJ
cord-018804-wj35q88f	237	21	affinity	affinity	NN
cord-018804-wj35q88f	237	22	of	of	IN
cord-018804-wj35q88f	237	23	the	the	DT
cord-018804-wj35q88f	237	24	polymerase	polymerase	NN
cord-018804-wj35q88f	237	25	for	for	IN
cord-018804-wj35q88f	237	26	the	the	DT
cord-018804-wj35q88f	237	27	mutagen	mutagen	NN
cord-018804-wj35q88f	237	28	,	,	,
cord-018804-wj35q88f	237	29	effect	effect	NN
cord-018804-wj35q88f	237	30	of	of	IN
cord-018804-wj35q88f	237	31	the	the	DT
cord-018804-wj35q88f	237	32	mutagen	mutagen	NN
cord-018804-wj35q88f	237	33	in	in	IN
cord-018804-wj35q88f	237	34	other	other	JJ
cord-018804-wj35q88f	237	35	viral	viral	JJ
cord-018804-wj35q88f	237	36	or	or	CC
cord-018804-wj35q88f	237	37	cellular	cellular	JJ
cord-018804-wj35q88f	237	38	processes	process	NNS
cord-018804-wj35q88f	237	39	,	,	,
cord-018804-wj35q88f	237	40	type	type	NN
cord-018804-wj35q88f	237	41	of	of	IN
cord-018804-wj35q88f	237	42	mutations	mutation	NNS
cord-018804-wj35q88f	237	43	preferentially	preferentially	RB
cord-018804-wj35q88f	237	44	induced	induce	VBN
cord-018804-wj35q88f	237	45	by	by	IN
cord-018804-wj35q88f	237	46	the	the	DT
cord-018804-wj35q88f	237	47	mutagen	mutagen	NN
cord-018804-wj35q88f	237	48	that	that	WDT
cord-018804-wj35q88f	237	49	can	can	MD
cord-018804-wj35q88f	237	50	affect	affect	VB
cord-018804-wj35q88f	237	51	viral	viral	JJ
cord-018804-wj35q88f	237	52	functions	function	NNS
cord-018804-wj35q88f	237	53	differently	differently	RB
cord-018804-wj35q88f	237	54	depending	depend	VBG
cord-018804-wj35q88f	237	55	on	on	IN
cord-018804-wj35q88f	237	56	the	the	DT
cord-018804-wj35q88f	237	57	nucleotide	nucleotide	JJ
cord-018804-wj35q88f	237	58	composition	composition	NN
cord-018804-wj35q88f	237	59	of	of	IN
cord-018804-wj35q88f	237	60	the	the	DT
cord-018804-wj35q88f	237	61	virus	virus	NN
cord-018804-wj35q88f	237	62	genomes	genome	NNS
cord-018804-wj35q88f	237	63	,	,	,
cord-018804-wj35q88f	237	64	etc	etc	FW
cord-018804-wj35q88f	237	65	.	.	FW
cord-018804-wj35q88f	237	66	,	,	,
cord-018804-wj35q88f	237	67	[	[	-LRB-
cord-018804-wj35q88f	237	68	53	53	CD
cord-018804-wj35q88f	237	69	]	]	-RRB-
cord-018804-wj35q88f	237	70	.	.	.
cord-018804-wj35q88f	238	1	The	the	DT
cord-018804-wj35q88f	238	2	influence	influence	NN
cord-018804-wj35q88f	238	3	of	of	IN
cord-018804-wj35q88f	238	4	variations	variation	NNS
cord-018804-wj35q88f	238	5	in	in	IN
cord-018804-wj35q88f	238	6	the	the	DT
cord-018804-wj35q88f	238	7	mutation	mutation	NN
cord-018804-wj35q88f	238	8	rate	rate	NN
cord-018804-wj35q88f	238	9	of	of	IN
cord-018804-wj35q88f	238	10	different	different	JJ
cord-018804-wj35q88f	238	11	virus	virus	NN
cord-018804-wj35q88f	238	12	polymerases	polymerase	NNS
cord-018804-wj35q88f	238	13	in	in	IN
cord-018804-wj35q88f	238	14	the	the	DT
cord-018804-wj35q88f	238	15	capacity	capacity	NN
cord-018804-wj35q88f	238	16	of	of	IN
cord-018804-wj35q88f	238	17	mutagens	mutagen	NNS
cord-018804-wj35q88f	238	18	to	to	TO
cord-018804-wj35q88f	238	19	extinguish	extinguish	VB
cord-018804-wj35q88f	238	20	infections	infection	NNS
cord-018804-wj35q88f	238	21	is	be	VBZ
cord-018804-wj35q88f	238	22	not	not	RB
cord-018804-wj35q88f	238	23	well	well	RB
cord-018804-wj35q88f	238	24	known	known	JJ
cord-018804-wj35q88f	238	25	.	.	.
cord-018804-wj35q88f	239	1	In	in	IN
cord-018804-wj35q88f	239	2	principle	principle	NN
cord-018804-wj35q88f	239	3	,	,	,
cord-018804-wj35q88f	239	4	it	-PRON-	PRP
cord-018804-wj35q88f	239	5	should	should	MD
cord-018804-wj35q88f	239	6	be	be	VB
cord-018804-wj35q88f	239	7	expected	expect	VBN
cord-018804-wj35q88f	239	8	that	that	IN
cord-018804-wj35q88f	239	9	the	the	DT
cord-018804-wj35q88f	239	10	closer	close	JJR
cord-018804-wj35q88f	239	11	is	be	VBZ
cord-018804-wj35q88f	239	12	the	the	DT
cord-018804-wj35q88f	239	13	virus	virus	NN
cord-018804-wj35q88f	239	14	to	to	IN
cord-018804-wj35q88f	239	15	the	the	DT
cord-018804-wj35q88f	239	16	error	error	NN
cord-018804-wj35q88f	239	17	threshold	threshold	NN
cord-018804-wj35q88f	239	18	,	,	,
cord-018804-wj35q88f	239	19	the	the	DT
cord-018804-wj35q88f	239	20	easier	easy	JJR
cord-018804-wj35q88f	239	21	should	should	MD
cord-018804-wj35q88f	239	22	be	be	VB
cord-018804-wj35q88f	239	23	its	-PRON-	PRP$
cord-018804-wj35q88f	239	24	extinction	extinction	NN
cord-018804-wj35q88f	239	25	by	by	IN
cord-018804-wj35q88f	239	26	increased	increase	VBN
cord-018804-wj35q88f	239	27	mutagenesis	mutagenesis	NN
cord-018804-wj35q88f	239	28	.	.	.
cord-018804-wj35q88f	240	1	However	however	RB
cord-018804-wj35q88f	240	2	,	,	,
cord-018804-wj35q88f	240	3	the	the	DT
cord-018804-wj35q88f	240	4	error	error	NN
cord-018804-wj35q88f	240	5	rate	rate	NN
cord-018804-wj35q88f	240	6	of	of	IN
cord-018804-wj35q88f	240	7	the	the	DT
cord-018804-wj35q88f	240	8	polymerase	polymerase	NN
cord-018804-wj35q88f	240	9	is	be	VBZ
cord-018804-wj35q88f	240	10	very	very	RB
cord-018804-wj35q88f	240	11	difficult	difficult	JJ
cord-018804-wj35q88f	240	12	to	to	TO
cord-018804-wj35q88f	240	13	estimate	estimate	VB
cord-018804-wj35q88f	240	14	,	,	,
cord-018804-wj35q88f	240	15	and	and	CC
cord-018804-wj35q88f	240	16	it	-PRON-	PRP
cord-018804-wj35q88f	240	17	can	can	MD
cord-018804-wj35q88f	240	18	change	change	VB
cord-018804-wj35q88f	240	19	depending	depend	VBG
cord-018804-wj35q88f	240	20	on	on	IN
cord-018804-wj35q88f	240	21	environmental	environmental	JJ
cord-018804-wj35q88f	240	22	factors	factor	NNS
cord-018804-wj35q88f	240	23	and	and	CC
cord-018804-wj35q88f	240	24	the	the	DT
cord-018804-wj35q88f	240	25	region	region	NN
cord-018804-wj35q88f	240	26	of	of	IN
cord-018804-wj35q88f	240	27	the	the	DT
cord-018804-wj35q88f	240	28	genome	genome	NN
cord-018804-wj35q88f	240	29	sequenced	sequence	VBN
cord-018804-wj35q88f	240	30	.	.	.
cord-018804-wj35q88f	241	1	Mutation	mutation	NN
cord-018804-wj35q88f	241	2	rates	rate	NNS
cord-018804-wj35q88f	241	3	are	be	VBP
cord-018804-wj35q88f	241	4	usually	usually	RB
cord-018804-wj35q88f	241	5	obtained	obtain	VBN
cord-018804-wj35q88f	241	6	from	from	IN
cord-018804-wj35q88f	241	7	measurements	measurement	NNS
cord-018804-wj35q88f	241	8	of	of	IN
cord-018804-wj35q88f	241	9	mutation	mutation	NN
cord-018804-wj35q88f	241	10	frequency	frequency	NN
cord-018804-wj35q88f	241	11	,	,	,
cord-018804-wj35q88f	241	12	a	a	DT
cord-018804-wj35q88f	241	13	procedure	procedure	NN
cord-018804-wj35q88f	241	14	that	that	WDT
cord-018804-wj35q88f	241	15	can	can	MD
cord-018804-wj35q88f	241	16	lead	lead	VB
cord-018804-wj35q88f	241	17	to	to	IN
cord-018804-wj35q88f	241	18	underestimation	underestimation	NN
cord-018804-wj35q88f	241	19	of	of	IN
cord-018804-wj35q88f	241	20	the	the	DT
cord-018804-wj35q88f	241	21	true	true	JJ
cord-018804-wj35q88f	241	22	mutation	mutation	NN
cord-018804-wj35q88f	241	23	rates	rate	NNS
cord-018804-wj35q88f	241	24	,	,	,
cord-018804-wj35q88f	241	25	because	because	IN
cord-018804-wj35q88f	241	26	only	only	RB
cord-018804-wj35q88f	241	27	replicating	replicate	VBG
cord-018804-wj35q88f	241	28	genomes	genome	NNS
cord-018804-wj35q88f	241	29	are	be	VBP
cord-018804-wj35q88f	241	30	abundant	abundant	JJ
cord-018804-wj35q88f	241	31	enough	enough	RB
cord-018804-wj35q88f	241	32	to	to	TO
cord-018804-wj35q88f	241	33	be	be	VB
cord-018804-wj35q88f	241	34	detected	detect	VBN
cord-018804-wj35q88f	241	35	.	.	.
cord-018804-wj35q88f	242	1	The	the	DT
cord-018804-wj35q88f	242	2	isolation	isolation	NN
cord-018804-wj35q88f	242	3	of	of	IN
cord-018804-wj35q88f	242	4	a	a	DT
cord-018804-wj35q88f	242	5	poliovirus	poliovirus	NN
cord-018804-wj35q88f	242	6	mutant	mutant	JJ
cord-018804-wj35q88f	242	7	with	with	IN
cord-018804-wj35q88f	242	8	a	a	DT
cord-018804-wj35q88f	242	9	high	high	JJ
cord-018804-wj35q88f	242	10	fidelity	fidelity	NN
cord-018804-wj35q88f	242	11	polymerase	polymerase	NN
cord-018804-wj35q88f	242	12	[	[	-LRB-
cord-018804-wj35q88f	242	13	54	54	CD
cord-018804-wj35q88f	242	14	,	,	,
cord-018804-wj35q88f	242	15	55	55	CD
cord-018804-wj35q88f	242	16	]	]	-RRB-
cord-018804-wj35q88f	242	17	that	that	WDT
cord-018804-wj35q88f	242	18	is	be	VBZ
cord-018804-wj35q88f	242	19	resistant	resistant	JJ
cord-018804-wj35q88f	242	20	to	to	IN
cord-018804-wj35q88f	242	21	the	the	DT
cord-018804-wj35q88f	242	22	action	action	NN
cord-018804-wj35q88f	242	23	of	of	IN
cord-018804-wj35q88f	242	24	ribavirin	ribavirin	NN
cord-018804-wj35q88f	242	25	and	and	CC
cord-018804-wj35q88f	242	26	other	other	JJ
cord-018804-wj35q88f	242	27	mutagens	mutagen	NNS
cord-018804-wj35q88f	242	28	clearly	clearly	RB
cord-018804-wj35q88f	242	29	indicates	indicate	VBZ
cord-018804-wj35q88f	242	30	that	that	IN
cord-018804-wj35q88f	242	31	the	the	DT
cord-018804-wj35q88f	242	32	error	error	NN
cord-018804-wj35q88f	242	33	rate	rate	NN
cord-018804-wj35q88f	242	34	of	of	IN
cord-018804-wj35q88f	242	35	a	a	DT
cord-018804-wj35q88f	242	36	particular	particular	JJ
cord-018804-wj35q88f	242	37	polymerase	polymerase	NN
cord-018804-wj35q88f	242	38	is	be	VBZ
cord-018804-wj35q88f	242	39	a	a	DT
cord-018804-wj35q88f	242	40	relevant	relevant	JJ
cord-018804-wj35q88f	242	41	factor	factor	NN
cord-018804-wj35q88f	242	42	contributing	contribute	VBG
cord-018804-wj35q88f	242	43	to	to	IN
cord-018804-wj35q88f	242	44	the	the	DT
cord-018804-wj35q88f	242	45	efficiency	efficiency	NN
cord-018804-wj35q88f	242	46	of	of	IN
cord-018804-wj35q88f	242	47	increased	increase	VBN
cord-018804-wj35q88f	242	48	mutagenesis	mutagenesis	NN
cord-018804-wj35q88f	242	49	to	to	TO
cord-018804-wj35q88f	242	50	extinguish	extinguish	VB
cord-018804-wj35q88f	242	51	viral	viral	JJ
cord-018804-wj35q88f	242	52	infections	infection	NNS
cord-018804-wj35q88f	242	53	.	.	.
cord-018804-wj35q88f	243	1	Studies	study	NNS
cord-018804-wj35q88f	243	2	in	in	IN
cord-018804-wj35q88f	243	3	both	both	DT
cord-018804-wj35q88f	243	4	riboviruses	riboviruse	NNS
cord-018804-wj35q88f	243	5	and	and	CC
cord-018804-wj35q88f	243	6	retroviruses	retrovirus	NNS
cord-018804-wj35q88f	243	7	suggest	suggest	VBP
cord-018804-wj35q88f	243	8	that	that	IN
cord-018804-wj35q88f	243	9	host	host	NN
cord-018804-wj35q88f	243	10	enzymes	enzyme	NNS
cord-018804-wj35q88f	243	11	also	also	RB
cord-018804-wj35q88f	243	12	represent	represent	VBP
cord-018804-wj35q88f	243	13	a	a	DT
cord-018804-wj35q88f	243	14	potential	potential	JJ
cord-018804-wj35q88f	243	15	source	source	NN
cord-018804-wj35q88f	243	16	of	of	IN
cord-018804-wj35q88f	243	17	variation	variation	NN
cord-018804-wj35q88f	243	18	by	by	IN
cord-018804-wj35q88f	243	19	RNA	RNA	NNP
cord-018804-wj35q88f	243	20	editing	edit	VBG
cord-018804-wj35q88f	243	21	[	[	-LRB-
cord-018804-wj35q88f	243	22	56	56	CD
cord-018804-wj35q88f	243	23	]	]	-RRB-
cord-018804-wj35q88f	243	24	.	.	.
cord-018804-wj35q88f	244	1	There	there	EX
cord-018804-wj35q88f	244	2	are	be	VBP
cord-018804-wj35q88f	244	3	some	some	DT
cord-018804-wj35q88f	244	4	cellular	cellular	JJ
cord-018804-wj35q88f	244	5	enzymes	enzyme	NNS
cord-018804-wj35q88f	244	6	able	able	JJ
cord-018804-wj35q88f	244	7	to	to	TO
cord-018804-wj35q88f	244	8	produce	produce	VB
cord-018804-wj35q88f	244	9	hypermutation	hypermutation	NN
cord-018804-wj35q88f	244	10	in	in	IN
cord-018804-wj35q88f	244	11	the	the	DT
cord-018804-wj35q88f	244	12	viral	viral	JJ
cord-018804-wj35q88f	244	13	genomes	genome	NNS
cord-018804-wj35q88f	244	14	,	,	,
cord-018804-wj35q88f	244	15	which	which	WDT
cord-018804-wj35q88f	244	16	occurs	occur	VBZ
cord-018804-wj35q88f	244	17	as	as	IN
cord-018804-wj35q88f	244	18	clusters	cluster	NNS
cord-018804-wj35q88f	244	19	of	of	IN
cord-018804-wj35q88f	244	20	specific	specific	JJ
cord-018804-wj35q88f	244	21	base	base	NN
cord-018804-wj35q88f	244	22	substitutions	substitution	NNS
cord-018804-wj35q88f	244	23	.	.	.
cord-018804-wj35q88f	245	1	A	a	DT
cord-018804-wj35q88f	245	2	documented	document	VBN
cord-018804-wj35q88f	245	3	example	example	NN
cord-018804-wj35q88f	245	4	is	be	VBZ
cord-018804-wj35q88f	245	5	the	the	DT
cord-018804-wj35q88f	245	6	enzyme	enzyme	NN
cord-018804-wj35q88f	245	7	APOBEC3	apobec3	NN
cord-018804-wj35q88f	245	8	G	g	NN
cord-018804-wj35q88f	245	9	,	,	,
cord-018804-wj35q88f	245	10	which	which	WDT
cord-018804-wj35q88f	245	11	has	have	VBZ
cord-018804-wj35q88f	245	12	been	be	VBN
cord-018804-wj35q88f	245	13	shown	show	VBN
cord-018804-wj35q88f	245	14	to	to	TO
cord-018804-wj35q88f	245	15	generate	generate	VB
cord-018804-wj35q88f	245	16	G→A	G→A	NNP
cord-018804-wj35q88f	245	17	hypermutations	hypermutation	NNS
cord-018804-wj35q88f	245	18	in	in	IN
cord-018804-wj35q88f	245	19	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	245	20	.	.	.
cord-018804-wj35q88f	246	1	Enzymes	enzyme	NNS
cord-018804-wj35q88f	246	2	of	of	IN
cord-018804-wj35q88f	246	3	this	this	DT
cord-018804-wj35q88f	246	4	type	type	NN
cord-018804-wj35q88f	246	5	could	could	MD
cord-018804-wj35q88f	246	6	act	act	VB
cord-018804-wj35q88f	246	7	as	as	IN
cord-018804-wj35q88f	246	8	a	a	DT
cord-018804-wj35q88f	246	9	natural	natural	JJ
cord-018804-wj35q88f	246	10	strategy	strategy	NN
cord-018804-wj35q88f	246	11	for	for	IN
cord-018804-wj35q88f	246	12	limiting	limit	VBG
cord-018804-wj35q88f	246	13	viral	viral	JJ
cord-018804-wj35q88f	246	14	infection	infection	NN
cord-018804-wj35q88f	246	15	by	by	IN
cord-018804-wj35q88f	246	16	increasing	increase	VBG
cord-018804-wj35q88f	246	17	mutagenesis	mutagenesis	NN
cord-018804-wj35q88f	246	18	above	above	IN
cord-018804-wj35q88f	246	19	the	the	DT
cord-018804-wj35q88f	246	20	error	error	NN
cord-018804-wj35q88f	246	21	threshold	threshold	NN
cord-018804-wj35q88f	246	22	.	.	.
cord-018804-wj35q88f	247	1	The	the	DT
cord-018804-wj35q88f	247	2	discovery	discovery	NN
cord-018804-wj35q88f	247	3	of	of	IN
cord-018804-wj35q88f	247	4	these	these	DT
cord-018804-wj35q88f	247	5	host	host	NN
cord-018804-wj35q88f	247	6	factors	factor	NNS
cord-018804-wj35q88f	247	7	constitutes	constitute	VBZ
cord-018804-wj35q88f	247	8	an	an	DT
cord-018804-wj35q88f	247	9	alternative	alternative	NN
cord-018804-wj35q88f	247	10	for	for	IN
cord-018804-wj35q88f	247	11	the	the	DT
cord-018804-wj35q88f	247	12	development	development	NN
cord-018804-wj35q88f	247	13	of	of	IN
cord-018804-wj35q88f	247	14	agents	agent	NNS
cord-018804-wj35q88f	247	15	that	that	WDT
cord-018804-wj35q88f	247	16	specifically	specifically	RB
cord-018804-wj35q88f	247	17	enhance	enhance	VBP
cord-018804-wj35q88f	247	18	the	the	DT
cord-018804-wj35q88f	247	19	natural	natural	JJ
cord-018804-wj35q88f	247	20	antiviral	antiviral	JJ
cord-018804-wj35q88f	247	21	activity	activity	NN
cord-018804-wj35q88f	247	22	of	of	IN
cord-018804-wj35q88f	247	23	cells	cell	NNS
cord-018804-wj35q88f	247	24	.	.	.
cord-018804-wj35q88f	248	1	Recently	recently	RB
cord-018804-wj35q88f	248	2	,	,	,
cord-018804-wj35q88f	248	3	extinction	extinction	NN
cord-018804-wj35q88f	248	4	by	by	IN
cord-018804-wj35q88f	248	5	lethal	lethal	JJ
cord-018804-wj35q88f	248	6	mutagenesis	mutagenesis	NN
cord-018804-wj35q88f	248	7	has	have	VBZ
cord-018804-wj35q88f	248	8	been	be	VBN
cord-018804-wj35q88f	248	9	shown	show	VBN
cord-018804-wj35q88f	248	10	to	to	TO
cord-018804-wj35q88f	248	11	involve	involve	VB
cord-018804-wj35q88f	248	12	more	more	JJR
cord-018804-wj35q88f	248	13	complex	complex	JJ
cord-018804-wj35q88f	248	14	mechanisms	mechanism	NNS
cord-018804-wj35q88f	248	15	than	than	IN
cord-018804-wj35q88f	248	16	those	those	DT
cord-018804-wj35q88f	248	17	affecting	affect	VBG
cord-018804-wj35q88f	248	18	only	only	RB
cord-018804-wj35q88f	248	19	the	the	DT
cord-018804-wj35q88f	248	20	replicative	replicative	JJ
cord-018804-wj35q88f	248	21	ability	ability	NN
cord-018804-wj35q88f	248	22	of	of	IN
cord-018804-wj35q88f	248	23	genomes	genome	NNS
cord-018804-wj35q88f	248	24	[	[	-LRB-
cord-018804-wj35q88f	248	25	44	44	CD
cord-018804-wj35q88f	248	26	]	]	-RRB-
cord-018804-wj35q88f	248	27	.	.	.
cord-018804-wj35q88f	249	1	It	-PRON-	PRP
cord-018804-wj35q88f	249	2	is	be	VBZ
cord-018804-wj35q88f	249	3	well	well	RB
cord-018804-wj35q88f	249	4	known	know	VBN
cord-018804-wj35q88f	249	5	that	that	IN
cord-018804-wj35q88f	249	6	in	in	IN
cord-018804-wj35q88f	249	7	a	a	DT
cord-018804-wj35q88f	249	8	normal	normal	JJ
cord-018804-wj35q88f	249	9	infection	infection	NN
cord-018804-wj35q88f	249	10	a	a	DT
cord-018804-wj35q88f	249	11	variable	variable	JJ
cord-018804-wj35q88f	249	12	amount	amount	NN
cord-018804-wj35q88f	249	13	of	of	IN
cord-018804-wj35q88f	249	14	the	the	DT
cord-018804-wj35q88f	249	15	viruses	virus	NNS
cord-018804-wj35q88f	249	16	produced	produce	VBN
cord-018804-wj35q88f	249	17	are	be	VBP
cord-018804-wj35q88f	249	18	non	non	JJ
cord-018804-wj35q88f	249	19	-	-	JJ
cord-018804-wj35q88f	249	20	infective	infective	JJ
cord-018804-wj35q88f	249	21	because	because	IN
cord-018804-wj35q88f	249	22	they	-PRON-	PRP
cord-018804-wj35q88f	249	23	are	be	VBP
cord-018804-wj35q88f	249	24	unable	unable	JJ
cord-018804-wj35q88f	249	25	to	to	TO
cord-018804-wj35q88f	249	26	code	code	VB
cord-018804-wj35q88f	249	27	for	for	IN
cord-018804-wj35q88f	249	28	all	all	DT
cord-018804-wj35q88f	249	29	functional	functional	JJ
cord-018804-wj35q88f	249	30	proteins	protein	NNS
cord-018804-wj35q88f	249	31	[	[	-LRB-
cord-018804-wj35q88f	249	32	57	57	CD
cord-018804-wj35q88f	249	33	]	]	-RRB-
cord-018804-wj35q88f	249	34	.	.	.
cord-018804-wj35q88f	250	1	However	however	RB
cord-018804-wj35q88f	250	2	,	,	,
cord-018804-wj35q88f	250	3	inside	inside	IN
cord-018804-wj35q88f	250	4	the	the	DT
cord-018804-wj35q88f	250	5	cell	cell	NN
cord-018804-wj35q88f	250	6	,	,	,
cord-018804-wj35q88f	250	7	it	-PRON-	PRP
cord-018804-wj35q88f	250	8	is	be	VBZ
cord-018804-wj35q88f	250	9	plausible	plausible	JJ
cord-018804-wj35q88f	250	10	that	that	IN
cord-018804-wj35q88f	250	11	many	many	JJ
cord-018804-wj35q88f	250	12	of	of	IN
cord-018804-wj35q88f	250	13	these	these	DT
cord-018804-wj35q88f	250	14	non	non	JJ
cord-018804-wj35q88f	250	15	-	-	JJ
cord-018804-wj35q88f	250	16	infective	infective	JJ
cord-018804-wj35q88f	250	17	genomes	genome	NNS
cord-018804-wj35q88f	250	18	behave	behave	VBP
cord-018804-wj35q88f	250	19	as	as	IN
cord-018804-wj35q88f	250	20	parasites	parasite	NNS
cord-018804-wj35q88f	250	21	and	and	CC
cord-018804-wj35q88f	250	22	replicate	replicate	VB
cord-018804-wj35q88f	250	23	using	use	VBG
cord-018804-wj35q88f	250	24	the	the	DT
cord-018804-wj35q88f	250	25	proteins	protein	NNS
cord-018804-wj35q88f	250	26	produced	produce	VBN
cord-018804-wj35q88f	250	27	by	by	IN
cord-018804-wj35q88f	250	28	other	other	JJ
cord-018804-wj35q88f	250	29	viruses	virus	NNS
cord-018804-wj35q88f	250	30	.	.	.
cord-018804-wj35q88f	251	1	When	when	WRB
cord-018804-wj35q88f	251	2	the	the	DT
cord-018804-wj35q88f	251	3	mutation	mutation	NN
cord-018804-wj35q88f	251	4	rate	rate	NN
cord-018804-wj35q88f	251	5	is	be	VBZ
cord-018804-wj35q88f	251	6	kept	keep	VBN
cord-018804-wj35q88f	251	7	below	below	IN
cord-018804-wj35q88f	251	8	a	a	DT
cord-018804-wj35q88f	251	9	critical	critical	JJ
cord-018804-wj35q88f	251	10	threshold	threshold	NN
cord-018804-wj35q88f	251	11	,	,	,
cord-018804-wj35q88f	251	12	defective	defective	JJ
cord-018804-wj35q88f	251	13	mutants	mutant	NNS
cord-018804-wj35q88f	251	14	maintain	maintain	VBP
cord-018804-wj35q88f	251	15	an	an	DT
cord-018804-wj35q88f	251	16	equilibrium	equilibrium	NN
cord-018804-wj35q88f	251	17	with	with	IN
cord-018804-wj35q88f	251	18	viable	viable	JJ
cord-018804-wj35q88f	251	19	genomes	genome	NNS
cord-018804-wj35q88f	251	20	.	.	.
cord-018804-wj35q88f	252	1	The	the	DT
cord-018804-wj35q88f	252	2	increase	increase	NN
cord-018804-wj35q88f	252	3	in	in	IN
cord-018804-wj35q88f	252	4	the	the	DT
cord-018804-wj35q88f	252	5	mutation	mutation	NN
cord-018804-wj35q88f	252	6	rate	rate	NN
cord-018804-wj35q88f	252	7	forces	force	NNS
cord-018804-wj35q88f	252	8	the	the	DT
cord-018804-wj35q88f	252	9	appearance	appearance	NN
cord-018804-wj35q88f	252	10	of	of	IN
cord-018804-wj35q88f	252	11	a	a	DT
cord-018804-wj35q88f	252	12	larger	large	JJR
cord-018804-wj35q88f	252	13	amount	amount	NN
cord-018804-wj35q88f	252	14	of	of	IN
cord-018804-wj35q88f	252	15	defective	defective	JJ
cord-018804-wj35q88f	252	16	genomes	genome	NNS
cord-018804-wj35q88f	252	17	that	that	WDT
cord-018804-wj35q88f	252	18	,	,	,
cord-018804-wj35q88f	252	19	beyond	beyond	IN
cord-018804-wj35q88f	252	20	a	a	DT
cord-018804-wj35q88f	252	21	critical	critical	JJ
cord-018804-wj35q88f	252	22	fraction	fraction	NN
cord-018804-wj35q88f	252	23	,	,	,
cord-018804-wj35q88f	252	24	can	can	MD
cord-018804-wj35q88f	252	25	exhaust	exhaust	VB
cord-018804-wj35q88f	252	26	the	the	DT
cord-018804-wj35q88f	252	27	Although	although	IN
cord-018804-wj35q88f	252	28	a	a	DT
cord-018804-wj35q88f	252	29	high	high	JJ
cord-018804-wj35q88f	252	30	amount	amount	NN
cord-018804-wj35q88f	252	31	of	of	IN
cord-018804-wj35q88f	252	32	RNA	RNA	NNP
cord-018804-wj35q88f	252	33	is	be	VBZ
cord-018804-wj35q88f	252	34	still	still	RB
cord-018804-wj35q88f	252	35	present	present	JJ
cord-018804-wj35q88f	252	36	in	in	IN
cord-018804-wj35q88f	252	37	the	the	DT
cord-018804-wj35q88f	252	38	samples	sample	NNS
cord-018804-wj35q88f	252	39	,	,	,
cord-018804-wj35q88f	252	40	infectivity	infectivity	NN
cord-018804-wj35q88f	252	41	declines	decline	NNS
cord-018804-wj35q88f	252	42	until	until	IN
cord-018804-wj35q88f	252	43	undetectable	undetectable	JJ
cord-018804-wj35q88f	252	44	levels	level	NNS
cord-018804-wj35q88f	252	45	,	,	,
cord-018804-wj35q88f	252	46	indicating	indicate	VBG
cord-018804-wj35q88f	252	47	that	that	IN
cord-018804-wj35q88f	252	48	replicative	replicative	JJ
cord-018804-wj35q88f	252	49	ability	ability	NN
cord-018804-wj35q88f	252	50	does	do	VBZ
cord-018804-wj35q88f	252	51	not	not	RB
cord-018804-wj35q88f	252	52	disappear	disappear	VB
cord-018804-wj35q88f	252	53	simultaneously	simultaneously	RB
cord-018804-wj35q88f	252	54	with	with	IN
cord-018804-wj35q88f	252	55	infectivity	infectivity	NN
cord-018804-wj35q88f	252	56	.	.	.
cord-018804-wj35q88f	253	1	Further	further	JJ
cord-018804-wj35q88f	253	2	details	detail	NNS
cord-018804-wj35q88f	253	3	of	of	IN
cord-018804-wj35q88f	253	4	this	this	DT
cord-018804-wj35q88f	253	5	experiment	experiment	NN
cord-018804-wj35q88f	253	6	can	can	MD
cord-018804-wj35q88f	253	7	be	be	VB
cord-018804-wj35q88f	253	8	found	find	VBN
cord-018804-wj35q88f	253	9	in	in	IN
cord-018804-wj35q88f	253	10	[	[	-LRB-
cord-018804-wj35q88f	253	11	44	44	CD
cord-018804-wj35q88f	253	12	]	]	-RRB-
cord-018804-wj35q88f	253	13	.	.	.
cord-018804-wj35q88f	254	1	Open	open	JJ
cord-018804-wj35q88f	254	2	symbols	symbol	NNS
cord-018804-wj35q88f	254	3	correspond	correspond	VBP
cord-018804-wj35q88f	254	4	to	to	IN
cord-018804-wj35q88f	254	5	the	the	DT
cord-018804-wj35q88f	254	6	intra	intra	JJ
cord-018804-wj35q88f	254	7	-	-	JJ
cord-018804-wj35q88f	254	8	cellular	cellular	JJ
cord-018804-wj35q88f	254	9	fraction	fraction	NN
cord-018804-wj35q88f	254	10	.	.	.
cord-018804-wj35q88f	255	1	Filled	fill	VBN
cord-018804-wj35q88f	255	2	symbols	symbol	NNS
cord-018804-wj35q88f	255	3	correspond	correspond	VBP
cord-018804-wj35q88f	255	4	to	to	IN
cord-018804-wj35q88f	255	5	the	the	DT
cord-018804-wj35q88f	255	6	supernatant	supernatant	JJ
cord-018804-wj35q88f	255	7	fraction	fraction	NN
cord-018804-wj35q88f	255	8	resources	resource	NNS
cord-018804-wj35q88f	255	9	necessary	necessary	JJ
cord-018804-wj35q88f	255	10	for	for	IN
cord-018804-wj35q88f	255	11	viral	viral	JJ
cord-018804-wj35q88f	255	12	replication	replication	NN
cord-018804-wj35q88f	255	13	,	,	,
cord-018804-wj35q88f	255	14	becoming	become	VBG
cord-018804-wj35q88f	255	15	an	an	DT
cord-018804-wj35q88f	255	16	additional	additional	JJ
cord-018804-wj35q88f	255	17	force	force	NN
cord-018804-wj35q88f	255	18	that	that	WDT
cord-018804-wj35q88f	255	19	can	can	MD
cord-018804-wj35q88f	255	20	promote	promote	VB
cord-018804-wj35q88f	255	21	extinction	extinction	NN
cord-018804-wj35q88f	255	22	.	.	.
cord-018804-wj35q88f	256	1	This	this	DT
cord-018804-wj35q88f	256	2	conceptual	conceptual	JJ
cord-018804-wj35q88f	256	3	framework	framework	NN
cord-018804-wj35q88f	256	4	derives	derive	VBZ
cord-018804-wj35q88f	256	5	from	from	IN
cord-018804-wj35q88f	256	6	several	several	JJ
cord-018804-wj35q88f	256	7	'	'	''
cord-018804-wj35q88f	256	8	in	in	IN
cord-018804-wj35q88f	256	9	vitro	vitro	FW
cord-018804-wj35q88f	256	10	'	'	POS
cord-018804-wj35q88f	256	11	experiments	experiment	NNS
cord-018804-wj35q88f	256	12	with	with	IN
cord-018804-wj35q88f	256	13	LCMV	LCMV	NNP
cord-018804-wj35q88f	256	14	[	[	-LRB-
cord-018804-wj35q88f	256	15	44	44	CD
cord-018804-wj35q88f	256	16	]	]	-RRB-
cord-018804-wj35q88f	256	17	.	.	.
cord-018804-wj35q88f	257	1	Infective	Infective	NNP
cord-018804-wj35q88f	257	2	viruses	virus	NNS
cord-018804-wj35q88f	257	3	and	and	CC
cord-018804-wj35q88f	257	4	RNA	RNA	NNP
cord-018804-wj35q88f	257	5	genomic	genomic	JJ
cord-018804-wj35q88f	257	6	molecules	molecule	NNS
cord-018804-wj35q88f	257	7	were	be	VBD
cord-018804-wj35q88f	257	8	monitored	monitor	VBN
cord-018804-wj35q88f	257	9	during	during	IN
cord-018804-wj35q88f	257	10	a	a	DT
cord-018804-wj35q88f	257	11	virological	virological	JJ
cord-018804-wj35q88f	257	12	steady	steady	JJ
cord-018804-wj35q88f	257	13	-	-	HYPH
cord-018804-wj35q88f	257	14	state	state	NN
cord-018804-wj35q88f	257	15	persistent	persistent	JJ
cord-018804-wj35q88f	257	16	infection	infection	NN
cord-018804-wj35q88f	257	17	of	of	IN
cord-018804-wj35q88f	257	18	BHK-21	BHK-21	NNP
cord-018804-wj35q88f	257	19	cells	cell	NNS
cord-018804-wj35q88f	257	20	by	by	IN
cord-018804-wj35q88f	257	21	LCMV	LCMV	NNP
cord-018804-wj35q88f	257	22	in	in	IN
cord-018804-wj35q88f	257	23	the	the	DT
cord-018804-wj35q88f	257	24	absence	absence	NN
cord-018804-wj35q88f	257	25	and	and	CC
cord-018804-wj35q88f	257	26	presence	presence	NN
cord-018804-wj35q88f	257	27	of	of	IN
cord-018804-wj35q88f	257	28	5-FU	5-fu	CD
cord-018804-wj35q88f	258	1	(	(	-LRB-
cord-018804-wj35q88f	258	2	Fig	Fig	NNP
cord-018804-wj35q88f	258	3	.	.	.
cord-018804-wj35q88f	258	4	15.2	15.2	CD
cord-018804-wj35q88f	258	5	)	)	-RRB-
cord-018804-wj35q88f	258	6	.	.	.
cord-018804-wj35q88f	259	1	In	in	IN
cord-018804-wj35q88f	259	2	the	the	DT
cord-018804-wj35q88f	259	3	course	course	NN
cord-018804-wj35q88f	259	4	of	of	IN
cord-018804-wj35q88f	259	5	the	the	DT
cord-018804-wj35q88f	259	6	infection	infection	NN
cord-018804-wj35q88f	259	7	,	,	,
cord-018804-wj35q88f	259	8	there	there	EX
cord-018804-wj35q88f	259	9	is	be	VBZ
cord-018804-wj35q88f	259	10	a	a	DT
cord-018804-wj35q88f	259	11	clear	clear	JJ
cord-018804-wj35q88f	259	12	increase	increase	NN
cord-018804-wj35q88f	259	13	in	in	IN
cord-018804-wj35q88f	259	14	the	the	DT
cord-018804-wj35q88f	259	15	number	number	NN
cord-018804-wj35q88f	259	16	of	of	IN
cord-018804-wj35q88f	259	17	genomic	genomic	JJ
cord-018804-wj35q88f	259	18	RNA	rna	NN
cord-018804-wj35q88f	259	19	molecules	molecule	NNS
cord-018804-wj35q88f	259	20	,	,	,
cord-018804-wj35q88f	259	21	both	both	CC
cord-018804-wj35q88f	259	22	in	in	IN
cord-018804-wj35q88f	259	23	the	the	DT
cord-018804-wj35q88f	259	24	intra	intra	JJ
cord-018804-wj35q88f	259	25	-	-	JJ
cord-018804-wj35q88f	259	26	cellular	cellular	JJ
cord-018804-wj35q88f	259	27	fraction	fraction	NN
cord-018804-wj35q88f	259	28	and	and	CC
cord-018804-wj35q88f	259	29	in	in	IN
cord-018804-wj35q88f	259	30	supernatants	supernatant	NNS
cord-018804-wj35q88f	259	31	of	of	IN
cord-018804-wj35q88f	259	32	control	control	NN
cord-018804-wj35q88f	259	33	and	and	CC
cord-018804-wj35q88f	259	34	mutagenized	mutagenized	JJ
cord-018804-wj35q88f	259	35	virus	virus	NN
cord-018804-wj35q88f	259	36	.	.	.
cord-018804-wj35q88f	260	1	However	however	RB
cord-018804-wj35q88f	260	2	,	,	,
cord-018804-wj35q88f	260	3	in	in	IN
cord-018804-wj35q88f	260	4	FU	FU	NNP
cord-018804-wj35q88f	260	5	-	-	HYPH
cord-018804-wj35q88f	260	6	treated	treat	VBN
cord-018804-wj35q88f	260	7	virus	virus	NN
cord-018804-wj35q88f	260	8	cultures	culture	NNS
cord-018804-wj35q88f	260	9	,	,	,
cord-018804-wj35q88f	260	10	infectivity	infectivity	NN
cord-018804-wj35q88f	260	11	declines	decline	VBZ
cord-018804-wj35q88f	260	12	and	and	CC
cord-018804-wj35q88f	260	13	falls	fall	VBZ
cord-018804-wj35q88f	260	14	below	below	IN
cord-018804-wj35q88f	260	15	detection	detection	NN
cord-018804-wj35q88f	260	16	,	,	,
cord-018804-wj35q88f	260	17	despite	despite	IN
cord-018804-wj35q88f	260	18	the	the	DT
cord-018804-wj35q88f	260	19	high	high	JJ
cord-018804-wj35q88f	260	20	number	number	NN
cord-018804-wj35q88f	260	21	of	of	IN
cord-018804-wj35q88f	260	22	genomic	genomic	JJ
cord-018804-wj35q88f	260	23	RNA	rna	NN
cord-018804-wj35q88f	260	24	molecules	molecule	NNS
cord-018804-wj35q88f	260	25	.	.	.
cord-018804-wj35q88f	261	1	The	the	DT
cord-018804-wj35q88f	261	2	number	number	NN
cord-018804-wj35q88f	261	3	of	of	IN
cord-018804-wj35q88f	261	4	infective	infective	JJ
cord-018804-wj35q88f	261	5	units	unit	NNS
cord-018804-wj35q88f	261	6	per	per	IN
cord-018804-wj35q88f	261	7	RNA	RNA	NNP
cord-018804-wj35q88f	261	8	molecule	molecule	NN
cord-018804-wj35q88f	261	9	as	as	IN
cord-018804-wj35q88f	261	10	a	a	DT
cord-018804-wj35q88f	261	11	function	function	NN
cord-018804-wj35q88f	261	12	of	of	IN
cord-018804-wj35q88f	261	13	the	the	DT
cord-018804-wj35q88f	261	14	mutation	mutation	NN
cord-018804-wj35q88f	261	15	frequency	frequency	NN
cord-018804-wj35q88f	261	16	yields	yield	VBZ
cord-018804-wj35q88f	261	17	a	a	DT
cord-018804-wj35q88f	261	18	curve	curve	NN
cord-018804-wj35q88f	261	19	with	with	IN
cord-018804-wj35q88f	261	20	a	a	DT
cord-018804-wj35q88f	261	21	sharp	sharp	JJ
cord-018804-wj35q88f	261	22	decay	decay	NN
cord-018804-wj35q88f	261	23	when	when	WRB
cord-018804-wj35q88f	261	24	the	the	DT
cord-018804-wj35q88f	261	25	mutation	mutation	NN
cord-018804-wj35q88f	261	26	frequency	frequency	NN
cord-018804-wj35q88f	261	27	overcomes	overcome	VBZ
cord-018804-wj35q88f	261	28	a	a	DT
cord-018804-wj35q88f	261	29	critical	critical	JJ
cord-018804-wj35q88f	261	30	threshold	threshold	NN
cord-018804-wj35q88f	261	31	.	.	.
cord-018804-wj35q88f	262	1	The	the	DT
cord-018804-wj35q88f	262	2	sudden	sudden	JJ
cord-018804-wj35q88f	262	3	loss	loss	NN
cord-018804-wj35q88f	262	4	of	of	IN
cord-018804-wj35q88f	262	5	infectivity	infectivity	NN
cord-018804-wj35q88f	262	6	takes	take	VBZ
cord-018804-wj35q88f	262	7	place	place	NN
cord-018804-wj35q88f	262	8	through	through	IN
cord-018804-wj35q88f	262	9	a	a	DT
cord-018804-wj35q88f	262	10	transition	transition	NN
cord-018804-wj35q88f	262	11	analogous	analogous	JJ
cord-018804-wj35q88f	262	12	to	to	IN
cord-018804-wj35q88f	262	13	that	that	DT
cord-018804-wj35q88f	262	14	predicted	predict	VBN
cord-018804-wj35q88f	262	15	by	by	IN
cord-018804-wj35q88f	262	16	error	error	NN
cord-018804-wj35q88f	262	17	catastrophe	catastrophe	NN
cord-018804-wj35q88f	262	18	theories	theory	NNS
cord-018804-wj35q88f	262	19	.	.	.
cord-018804-wj35q88f	263	1	However	however	RB
cord-018804-wj35q88f	263	2	,	,	,
cord-018804-wj35q88f	263	3	the	the	DT
cord-018804-wj35q88f	263	4	unexpected	unexpected	JJ
cord-018804-wj35q88f	263	5	outcome	outcome	NN
cord-018804-wj35q88f	263	6	of	of	IN
cord-018804-wj35q88f	263	7	the	the	DT
cord-018804-wj35q88f	263	8	experiment	experiment	NN
cord-018804-wj35q88f	263	9	was	be	VBD
cord-018804-wj35q88f	263	10	the	the	DT
cord-018804-wj35q88f	263	11	presence	presence	NN
cord-018804-wj35q88f	263	12	of	of	IN
cord-018804-wj35q88f	263	13	large	large	JJ
cord-018804-wj35q88f	263	14	numbers	number	NNS
cord-018804-wj35q88f	263	15	of	of	IN
cord-018804-wj35q88f	263	16	RNA	RNA	NNP
cord-018804-wj35q88f	263	17	molecules	molecule	NNS
cord-018804-wj35q88f	263	18	,	,	,
cord-018804-wj35q88f	263	19	revealing	reveal	VBG
cord-018804-wj35q88f	263	20	that	that	IN
cord-018804-wj35q88f	263	21	the	the	DT
cord-018804-wj35q88f	263	22	replicative	replicative	JJ
cord-018804-wj35q88f	263	23	ability	ability	NN
cord-018804-wj35q88f	263	24	does	do	VBZ
cord-018804-wj35q88f	263	25	not	not	RB
cord-018804-wj35q88f	263	26	disappear	disappear	VB
cord-018804-wj35q88f	263	27	simultaneously	simultaneously	RB
cord-018804-wj35q88f	263	28	with	with	IN
cord-018804-wj35q88f	263	29	infectivity	infectivity	NN
cord-018804-wj35q88f	263	30	.	.	.
cord-018804-wj35q88f	264	1	Similar	similar	JJ
cord-018804-wj35q88f	264	2	results	result	NNS
cord-018804-wj35q88f	264	3	have	have	VBP
cord-018804-wj35q88f	264	4	been	be	VBN
cord-018804-wj35q88f	264	5	found	find	VBN
cord-018804-wj35q88f	264	6	with	with	IN
cord-018804-wj35q88f	264	7	poliovirus	poliovirus	NN
cord-018804-wj35q88f	264	8	and	and	CC
cord-018804-wj35q88f	264	9	Hantaan	Hantaan	NNP
cord-018804-wj35q88f	264	10	virus	virus	NN
cord-018804-wj35q88f	264	11	where	where	WRB
cord-018804-wj35q88f	264	12	decreases	decrease	VBZ
cord-018804-wj35q88f	264	13	in	in	IN
cord-018804-wj35q88f	264	14	infectivity	infectivity	NN
cord-018804-wj35q88f	264	15	preceded	precede	VBD
cord-018804-wj35q88f	264	16	decreases	decrease	NNS
cord-018804-wj35q88f	264	17	in	in	IN
cord-018804-wj35q88f	264	18	viral	viral	JJ
cord-018804-wj35q88f	264	19	RNA	RNA	NNP
cord-018804-wj35q88f	264	20	levels	level	NNS
cord-018804-wj35q88f	264	21	[	[	-LRB-
cord-018804-wj35q88f	264	22	42	42	CD
cord-018804-wj35q88f	264	23	,	,	,
cord-018804-wj35q88f	264	24	58	58	CD
cord-018804-wj35q88f	264	25	,	,	,
cord-018804-wj35q88f	264	26	59	59	CD
cord-018804-wj35q88f	264	27	]	]	-RRB-
cord-018804-wj35q88f	264	28	.	.	.
cord-018804-wj35q88f	265	1	Lethal	lethal	JJ
cord-018804-wj35q88f	265	2	mutagenesis	mutagenesis	NN
cord-018804-wj35q88f	265	3	probably	probably	RB
cord-018804-wj35q88f	265	4	presents	present	VBZ
cord-018804-wj35q88f	265	5	many	many	JJ
cord-018804-wj35q88f	265	6	of	of	IN
cord-018804-wj35q88f	265	7	the	the	DT
cord-018804-wj35q88f	265	8	same	same	JJ
cord-018804-wj35q88f	265	9	difficulties	difficulty	NNS
cord-018804-wj35q88f	265	10	as	as	IN
cord-018804-wj35q88f	265	11	conventional	conventional	JJ
cord-018804-wj35q88f	265	12	antiviral	antiviral	JJ
cord-018804-wj35q88f	265	13	therapy	therapy	NN
cord-018804-wj35q88f	265	14	.	.	.
cord-018804-wj35q88f	266	1	An	an	DT
cord-018804-wj35q88f	266	2	important	important	JJ
cord-018804-wj35q88f	266	3	problem	problem	NN
cord-018804-wj35q88f	266	4	takes	take	VBZ
cord-018804-wj35q88f	266	5	place	place	NN
cord-018804-wj35q88f	266	6	in	in	IN
cord-018804-wj35q88f	266	7	viruses	virus	NNS
cord-018804-wj35q88f	266	8	,	,	,
cord-018804-wj35q88f	266	9	such	such	JJ
cord-018804-wj35q88f	266	10	as	as	IN
cord-018804-wj35q88f	266	11	retroviruses	retrovirus	NNS
cord-018804-wj35q88f	266	12	,	,	,
cord-018804-wj35q88f	266	13	that	that	WDT
cord-018804-wj35q88f	266	14	can	can	MD
cord-018804-wj35q88f	266	15	stay	stay	VB
cord-018804-wj35q88f	266	16	in	in	IN
cord-018804-wj35q88f	266	17	a	a	DT
cord-018804-wj35q88f	266	18	latent	latent	JJ
cord-018804-wj35q88f	266	19	state	state	NN
cord-018804-wj35q88f	266	20	during	during	IN
cord-018804-wj35q88f	266	21	a	a	DT
cord-018804-wj35q88f	266	22	long	long	JJ
cord-018804-wj35q88f	266	23	time	time	NN
cord-018804-wj35q88f	266	24	in	in	IN
cord-018804-wj35q88f	266	25	cellular	cellular	JJ
cord-018804-wj35q88f	266	26	or	or	CC
cord-018804-wj35q88f	266	27	anatomical	anatomical	JJ
cord-018804-wj35q88f	266	28	reservoirs	reservoir	NNS
cord-018804-wj35q88f	266	29	.	.	.
cord-018804-wj35q88f	267	1	Activation	activation	NN
cord-018804-wj35q88f	267	2	of	of	IN
cord-018804-wj35q88f	267	3	these	these	DT
cord-018804-wj35q88f	267	4	latent	latent	JJ
cord-018804-wj35q88f	267	5	viruses	virus	NNS
cord-018804-wj35q88f	267	6	can	can	MD
cord-018804-wj35q88f	267	7	contribute	contribute	VB
cord-018804-wj35q88f	267	8	to	to	IN
cord-018804-wj35q88f	267	9	the	the	DT
cord-018804-wj35q88f	267	10	resurgence	resurgence	NN
cord-018804-wj35q88f	267	11	of	of	IN
cord-018804-wj35q88f	267	12	the	the	DT
cord-018804-wj35q88f	267	13	disease	disease	NN
cord-018804-wj35q88f	267	14	after	after	IN
cord-018804-wj35q88f	267	15	interruption	interruption	NN
cord-018804-wj35q88f	267	16	of	of	IN
cord-018804-wj35q88f	267	17	drug	drug	NN
cord-018804-wj35q88f	267	18	treatment	treatment	NN
cord-018804-wj35q88f	267	19	in	in	IN
cord-018804-wj35q88f	267	20	vivo	vivo	NNP
cord-018804-wj35q88f	267	21	[	[	-LRB-
cord-018804-wj35q88f	267	22	60	60	CD
cord-018804-wj35q88f	267	23	]	]	-RRB-
cord-018804-wj35q88f	267	24	.	.	.
cord-018804-wj35q88f	268	1	However	however	RB
cord-018804-wj35q88f	268	2	,	,	,
cord-018804-wj35q88f	268	3	the	the	DT
cord-018804-wj35q88f	268	4	strongest	strong	JJS
cord-018804-wj35q88f	268	5	obstacle	obstacle	NN
cord-018804-wj35q88f	268	6	to	to	IN
cord-018804-wj35q88f	268	7	antiviral	antiviral	JJ
cord-018804-wj35q88f	268	8	mutagenesis	mutagenesis	NN
cord-018804-wj35q88f	268	9	is	be	VBZ
cord-018804-wj35q88f	268	10	the	the	DT
cord-018804-wj35q88f	268	11	appearance	appearance	NN
cord-018804-wj35q88f	268	12	of	of	IN
cord-018804-wj35q88f	268	13	drug	drug	NN
cord-018804-wj35q88f	268	14	-	-	HYPH
cord-018804-wj35q88f	268	15	resistant	resistant	JJ
cord-018804-wj35q88f	268	16	mutants	mutant	NNS
cord-018804-wj35q88f	268	17	due	due	IN
cord-018804-wj35q88f	268	18	to	to	IN
cord-018804-wj35q88f	268	19	the	the	DT
cord-018804-wj35q88f	268	20	presence	presence	NN
cord-018804-wj35q88f	268	21	of	of	IN
cord-018804-wj35q88f	268	22	enhanced	enhance	VBN
cord-018804-wj35q88f	268	23	fidelity	fidelity	NN
cord-018804-wj35q88f	268	24	polymerases	polymerase	NNS
cord-018804-wj35q88f	268	25	.	.	.
cord-018804-wj35q88f	269	1	Possibly	possibly	RB
cord-018804-wj35q88f	269	2	these	these	DT
cord-018804-wj35q88f	269	3	mutants	mutant	NNS
cord-018804-wj35q88f	269	4	are	be	VBP
cord-018804-wj35q88f	269	5	less	less	RBR
cord-018804-wj35q88f	269	6	able	able	JJ
cord-018804-wj35q88f	269	7	to	to	TO
cord-018804-wj35q88f	269	8	generate	generate	VB
cord-018804-wj35q88f	269	9	resistances	resistance	NNS
cord-018804-wj35q88f	269	10	to	to	IN
cord-018804-wj35q88f	269	11	other	other	JJ
cord-018804-wj35q88f	269	12	antiviral	antiviral	JJ
cord-018804-wj35q88f	269	13	drugs	drug	NNS
cord-018804-wj35q88f	269	14	,	,	,
cord-018804-wj35q88f	269	15	due	due	IN
cord-018804-wj35q88f	269	16	to	to	IN
cord-018804-wj35q88f	269	17	the	the	DT
cord-018804-wj35q88f	269	18	diminished	diminished	JJ
cord-018804-wj35q88f	269	19	ability	ability	NN
cord-018804-wj35q88f	269	20	of	of	IN
cord-018804-wj35q88f	269	21	adaptation	adaptation	NN
cord-018804-wj35q88f	269	22	that	that	WDT
cord-018804-wj35q88f	269	23	results	result	VBZ
cord-018804-wj35q88f	269	24	from	from	IN
cord-018804-wj35q88f	269	25	the	the	DT
cord-018804-wj35q88f	269	26	reduction	reduction	NN
cord-018804-wj35q88f	269	27	of	of	IN
cord-018804-wj35q88f	269	28	the	the	DT
cord-018804-wj35q88f	269	29	genetic	genetic	JJ
cord-018804-wj35q88f	269	30	diversity	diversity	NN
cord-018804-wj35q88f	269	31	because	because	IN
cord-018804-wj35q88f	269	32	of	of	IN
cord-018804-wj35q88f	269	33	the	the	DT
cord-018804-wj35q88f	269	34	higher	high	JJR
cord-018804-wj35q88f	269	35	fidelity	fidelity	NN
cord-018804-wj35q88f	269	36	of	of	IN
cord-018804-wj35q88f	269	37	the	the	DT
cord-018804-wj35q88f	269	38	polymerase	polymerase	NN
cord-018804-wj35q88f	269	39	.	.	.
cord-018804-wj35q88f	270	1	Therefore	therefore	RB
cord-018804-wj35q88f	270	2	,	,	,
cord-018804-wj35q88f	270	3	combined	combined	JJ
cord-018804-wj35q88f	270	4	therapies	therapy	NNS
cord-018804-wj35q88f	270	5	consisting	consist	VBG
cord-018804-wj35q88f	270	6	of	of	IN
cord-018804-wj35q88f	270	7	lethal	lethal	JJ
cord-018804-wj35q88f	270	8	mutagenesis	mutagenesis	NN
cord-018804-wj35q88f	270	9	and	and	CC
cord-018804-wj35q88f	270	10	other	other	JJ
cord-018804-wj35q88f	270	11	antivirals	antiviral	NNS
cord-018804-wj35q88f	270	12	could	could	MD
cord-018804-wj35q88f	270	13	be	be	VB
cord-018804-wj35q88f	270	14	a	a	DT
cord-018804-wj35q88f	270	15	promising	promising	JJ
cord-018804-wj35q88f	270	16	strategy	strategy	NN
cord-018804-wj35q88f	270	17	for	for	IN
cord-018804-wj35q88f	270	18	the	the	DT
cord-018804-wj35q88f	270	19	treatment	treatment	NN
cord-018804-wj35q88f	270	20	of	of	IN
cord-018804-wj35q88f	270	21	viral	viral	JJ
cord-018804-wj35q88f	270	22	infections	infection	NNS
cord-018804-wj35q88f	270	23	[	[	-LRB-
cord-018804-wj35q88f	270	24	54	54	CD
cord-018804-wj35q88f	270	25	]	]	-RRB-
cord-018804-wj35q88f	270	26	.	.	.
cord-018804-wj35q88f	271	1	The	the	DT
cord-018804-wj35q88f	271	2	probability	probability	NN
cord-018804-wj35q88f	271	3	of	of	IN
cord-018804-wj35q88f	271	4	extinction	extinction	NN
cord-018804-wj35q88f	271	5	of	of	IN
cord-018804-wj35q88f	271	6	small	small	JJ
cord-018804-wj35q88f	271	7	asexual	asexual	JJ
cord-018804-wj35q88f	271	8	populations	population	NNS
cord-018804-wj35q88f	271	9	due	due	JJ
cord-018804-wj35q88f	271	10	to	to	IN
cord-018804-wj35q88f	271	11	the	the	DT
cord-018804-wj35q88f	271	12	accumulation	accumulation	NN
cord-018804-wj35q88f	271	13	of	of	IN
cord-018804-wj35q88f	271	14	mutations	mutation	NNS
cord-018804-wj35q88f	271	15	was	be	VBD
cord-018804-wj35q88f	271	16	first	first	RB
cord-018804-wj35q88f	271	17	studied	study	VBN
cord-018804-wj35q88f	271	18	by	by	IN
cord-018804-wj35q88f	271	19	Muller	Muller	NNP
cord-018804-wj35q88f	271	20	several	several	JJ
cord-018804-wj35q88f	271	21	decades	decade	NNS
cord-018804-wj35q88f	271	22	ago	ago	RB
cord-018804-wj35q88f	271	23	[	[	-LRB-
cord-018804-wj35q88f	271	24	61	61	CD
cord-018804-wj35q88f	271	25	]	]	-RRB-
cord-018804-wj35q88f	271	26	.	.	.
cord-018804-wj35q88f	272	1	He	-PRON-	PRP
cord-018804-wj35q88f	272	2	predicted	predict	VBD
cord-018804-wj35q88f	272	3	that	that	IN
cord-018804-wj35q88f	272	4	the	the	DT
cord-018804-wj35q88f	272	5	genomes	genome	NNS
cord-018804-wj35q88f	272	6	with	with	IN
cord-018804-wj35q88f	272	7	the	the	DT
cord-018804-wj35q88f	272	8	lowest	low	JJS
cord-018804-wj35q88f	272	9	mutational	mutational	JJ
cord-018804-wj35q88f	272	10	load	load	NN
cord-018804-wj35q88f	272	11	could	could	MD
cord-018804-wj35q88f	272	12	be	be	VB
cord-018804-wj35q88f	272	13	stochastically	stochastically	RB
cord-018804-wj35q88f	272	14	lost	lose	VBN
cord-018804-wj35q88f	272	15	due	due	IN
cord-018804-wj35q88f	272	16	to	to	IN
cord-018804-wj35q88f	272	17	population	population	NN
cord-018804-wj35q88f	272	18	fluctuations	fluctuation	NNS
cord-018804-wj35q88f	272	19	through	through	IN
cord-018804-wj35q88f	272	20	a	a	DT
cord-018804-wj35q88f	272	21	mechanism	mechanism	NN
cord-018804-wj35q88f	272	22	similar	similar	JJ
cord-018804-wj35q88f	272	23	to	to	IN
cord-018804-wj35q88f	272	24	the	the	DT
cord-018804-wj35q88f	272	25	clicks	click	NNS
cord-018804-wj35q88f	272	26	of	of	IN
cord-018804-wj35q88f	272	27	a	a	DT
cord-018804-wj35q88f	272	28	ratchet	ratchet	NN
cord-018804-wj35q88f	272	29	.	.	.
cord-018804-wj35q88f	273	1	When	when	WRB
cord-018804-wj35q88f	273	2	the	the	DT
cord-018804-wj35q88f	273	3	ratchet	ratchet	NN
cord-018804-wj35q88f	273	4	clicks	click	VBZ
cord-018804-wj35q88f	273	5	the	the	DT
cord-018804-wj35q88f	273	6	first	first	JJ
cord-018804-wj35q88f	273	7	time	time	NN
cord-018804-wj35q88f	273	8	,	,	,
cord-018804-wj35q88f	273	9	this	this	DT
cord-018804-wj35q88f	273	10	means	mean	VBZ
cord-018804-wj35q88f	273	11	that	that	IN
cord-018804-wj35q88f	273	12	the	the	DT
cord-018804-wj35q88f	273	13	genomes	genome	NNS
cord-018804-wj35q88f	273	14	with	with	IN
cord-018804-wj35q88f	273	15	no	no	DT
cord-018804-wj35q88f	273	16	mutations	mutation	NNS
cord-018804-wj35q88f	273	17	are	be	VBP
cord-018804-wj35q88f	273	18	lost	lose	VBN
cord-018804-wj35q88f	273	19	and	and	CC
cord-018804-wj35q88f	273	20	the	the	DT
cord-018804-wj35q88f	273	21	least	least	RBS
cord-018804-wj35q88f	273	22	loaded	loaded	JJ
cord-018804-wj35q88f	273	23	class	class	NN
cord-018804-wj35q88f	273	24	corresponds	correspond	VBZ
cord-018804-wj35q88f	273	25	to	to	IN
cord-018804-wj35q88f	273	26	individuals	individual	NNS
cord-018804-wj35q88f	273	27	carrying	carry	VBG
cord-018804-wj35q88f	273	28	one	one	CD
cord-018804-wj35q88f	273	29	mutation	mutation	NN
cord-018804-wj35q88f	273	30	.	.	.
cord-018804-wj35q88f	274	1	In	in	IN
cord-018804-wj35q88f	274	2	the	the	DT
cord-018804-wj35q88f	274	3	next	next	JJ
cord-018804-wj35q88f	274	4	click	click	NN
cord-018804-wj35q88f	274	5	,	,	,
cord-018804-wj35q88f	274	6	the	the	DT
cord-018804-wj35q88f	274	7	one	one	CD
cord-018804-wj35q88f	274	8	-	-	HYPH
cord-018804-wj35q88f	274	9	mutation	mutation	NN
cord-018804-wj35q88f	274	10	class	class	NN
cord-018804-wj35q88f	274	11	disappears	disappear	VBZ
cord-018804-wj35q88f	274	12	by	by	IN
cord-018804-wj35q88f	274	13	a	a	DT
cord-018804-wj35q88f	274	14	similar	similar	JJ
cord-018804-wj35q88f	274	15	mechanism	mechanism	NN
cord-018804-wj35q88f	274	16	,	,	,
cord-018804-wj35q88f	274	17	and	and	CC
cord-018804-wj35q88f	274	18	the	the	DT
cord-018804-wj35q88f	274	19	least	least	RBS
cord-018804-wj35q88f	274	20	mutated	mutated	JJ
cord-018804-wj35q88f	274	21	class	class	NN
cord-018804-wj35q88f	274	22	corresponds	correspond	VBZ
cord-018804-wj35q88f	274	23	now	now	RB
cord-018804-wj35q88f	274	24	to	to	IN
cord-018804-wj35q88f	274	25	genomes	genome	NNS
cord-018804-wj35q88f	274	26	with	with	IN
cord-018804-wj35q88f	274	27	two	two	CD
cord-018804-wj35q88f	274	28	mutations	mutation	NNS
cord-018804-wj35q88f	274	29	and	and	CC
cord-018804-wj35q88f	274	30	so	so	RB
cord-018804-wj35q88f	274	31	on	on	RB
cord-018804-wj35q88f	274	32	.	.	.
cord-018804-wj35q88f	275	1	At	at	IN
cord-018804-wj35q88f	275	2	that	that	DT
cord-018804-wj35q88f	275	3	time	time	NN
cord-018804-wj35q88f	275	4	it	-PRON-	PRP
cord-018804-wj35q88f	275	5	was	be	VBD
cord-018804-wj35q88f	275	6	believed	believe	VBN
cord-018804-wj35q88f	275	7	that	that	IN
cord-018804-wj35q88f	275	8	the	the	DT
cord-018804-wj35q88f	275	9	least	least	RBS
cord-018804-wj35q88f	275	10	mutated	mutate	VBN
cord-018804-wj35q88f	275	11	genomes	genome	NNS
cord-018804-wj35q88f	275	12	were	be	VBD
cord-018804-wj35q88f	275	13	the	the	DT
cord-018804-wj35q88f	275	14	best	well	RBS
cord-018804-wj35q88f	275	15	adapted	adapt	VBN
cord-018804-wj35q88f	275	16	and	and	CC
cord-018804-wj35q88f	275	17	that	that	IN
cord-018804-wj35q88f	275	18	reversions	reversion	NNS
cord-018804-wj35q88f	275	19	were	be	VBD
cord-018804-wj35q88f	275	20	the	the	DT
cord-018804-wj35q88f	275	21	only	only	JJ
cord-018804-wj35q88f	275	22	mechanism	mechanism	NN
cord-018804-wj35q88f	275	23	able	able	JJ
cord-018804-wj35q88f	275	24	to	to	TO
cord-018804-wj35q88f	275	25	recover	recover	VB
cord-018804-wj35q88f	275	26	fitness	fitness	NN
cord-018804-wj35q88f	275	27	.	.	.
cord-018804-wj35q88f	276	1	Thus	thus	RB
cord-018804-wj35q88f	276	2	,	,	,
cord-018804-wj35q88f	276	3	this	this	DT
cord-018804-wj35q88f	276	4	process	process	NN
cord-018804-wj35q88f	276	5	,	,	,
cord-018804-wj35q88f	276	6	which	which	WDT
cord-018804-wj35q88f	276	7	is	be	VBZ
cord-018804-wj35q88f	276	8	particularly	particularly	RB
cord-018804-wj35q88f	276	9	effective	effective	JJ
cord-018804-wj35q88f	276	10	at	at	IN
cord-018804-wj35q88f	276	11	high	high	JJ
cord-018804-wj35q88f	276	12	mutation	mutation	NN
cord-018804-wj35q88f	276	13	rates	rate	NNS
cord-018804-wj35q88f	276	14	,	,	,
cord-018804-wj35q88f	276	15	as	as	IN
cord-018804-wj35q88f	276	16	it	-PRON-	PRP
cord-018804-wj35q88f	276	17	happens	happen	VBZ
cord-018804-wj35q88f	276	18	in	in	IN
cord-018804-wj35q88f	276	19	RNA	RNA	NNP
cord-018804-wj35q88f	276	20	viruses	virus	NNS
cord-018804-wj35q88f	276	21	,	,	,
cord-018804-wj35q88f	276	22	should	should	MD
cord-018804-wj35q88f	276	23	inevitably	inevitably	RB
cord-018804-wj35q88f	276	24	imply	imply	VB
cord-018804-wj35q88f	276	25	a	a	DT
cord-018804-wj35q88f	276	26	progressive	progressive	JJ
cord-018804-wj35q88f	276	27	fitness	fitness	NN
cord-018804-wj35q88f	276	28	loss	loss	NN
cord-018804-wj35q88f	276	29	that	that	WDT
cord-018804-wj35q88f	276	30	can	can	MD
cord-018804-wj35q88f	276	31	lead	lead	VB
cord-018804-wj35q88f	276	32	populations	population	NNS
cord-018804-wj35q88f	276	33	to	to	IN
cord-018804-wj35q88f	276	34	extinction	extinction	NN
cord-018804-wj35q88f	276	35	.	.	.
cord-018804-wj35q88f	277	1	The	the	DT
cord-018804-wj35q88f	277	2	experimental	experimental	JJ
cord-018804-wj35q88f	277	3	study	study	NN
cord-018804-wj35q88f	277	4	on	on	IN
cord-018804-wj35q88f	277	5	the	the	DT
cord-018804-wj35q88f	277	6	transmission	transmission	NN
cord-018804-wj35q88f	277	7	of	of	IN
cord-018804-wj35q88f	277	8	RNA	RNA	NNP
cord-018804-wj35q88f	277	9	viruses	virus	NNS
cord-018804-wj35q88f	277	10	through	through	IN
cord-018804-wj35q88f	277	11	successive	successive	JJ
cord-018804-wj35q88f	277	12	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	277	13	usually	usually	RB
cord-018804-wj35q88f	277	14	is	be	VBZ
cord-018804-wj35q88f	277	15	carried	carry	VBN
cord-018804-wj35q88f	277	16	out	out	RP
cord-018804-wj35q88f	277	17	making	make	VBG
cord-018804-wj35q88f	277	18	serial	serial	JJ
cord-018804-wj35q88f	277	19	plaque	plaque	NN
cord-018804-wj35q88f	277	20	-	-	HYPH
cord-018804-wj35q88f	277	21	to	to	IN
cord-018804-wj35q88f	277	22	-	-	HYPH
cord-018804-wj35q88f	277	23	plaque	plaque	NN
cord-018804-wj35q88f	277	24	transfers	transfer	NNS
cord-018804-wj35q88f	277	25	(	(	-LRB-
cord-018804-wj35q88f	277	26	Fig	Fig	NNP
cord-018804-wj35q88f	277	27	.	.	.
cord-018804-wj35q88f	277	28	15.3	15.3	CD
cord-018804-wj35q88f	277	29	)	)	-RRB-
cord-018804-wj35q88f	277	30	.	.	.
cord-018804-wj35q88f	278	1	At	at	IN
cord-018804-wj35q88f	278	2	each	each	DT
cord-018804-wj35q88f	278	3	transfer	transfer	NN
cord-018804-wj35q88f	278	4	,	,	,
cord-018804-wj35q88f	278	5	the	the	DT
cord-018804-wj35q88f	278	6	viral	viral	JJ
cord-018804-wj35q88f	278	7	population	population	NN
cord-018804-wj35q88f	278	8	is	be	VBZ
cord-018804-wj35q88f	278	9	plated	plate	VBN
cord-018804-wj35q88f	278	10	at	at	IN
cord-018804-wj35q88f	278	11	low	low	JJ
cord-018804-wj35q88f	278	12	multiplicity	multiplicity	NN
cord-018804-wj35q88f	278	13	of	of	IN
cord-018804-wj35q88f	278	14	infection	infection	NN
cord-018804-wj35q88f	278	15	to	to	TO
cord-018804-wj35q88f	278	16	get	get	VB
cord-018804-wj35q88f	278	17	well	well	RB
cord-018804-wj35q88f	278	18	-	-	HYPH
cord-018804-wj35q88f	278	19	isolated	isolate	VBN
cord-018804-wj35q88f	278	20	lytic	lytic	JJ
cord-018804-wj35q88f	278	21	plaques	plaque	NNS
cord-018804-wj35q88f	278	22	that	that	WDT
cord-018804-wj35q88f	278	23	are	be	VBP
cord-018804-wj35q88f	278	24	the	the	DT
cord-018804-wj35q88f	278	25	result	result	NN
cord-018804-wj35q88f	278	26	of	of	IN
cord-018804-wj35q88f	278	27	the	the	DT
cord-018804-wj35q88f	278	28	infection	infection	NN
cord-018804-wj35q88f	278	29	by	by	IN
cord-018804-wj35q88f	278	30	a	a	DT
cord-018804-wj35q88f	278	31	single	single	JJ
cord-018804-wj35q88f	278	32	virus	virus	NN
cord-018804-wj35q88f	278	33	,	,	,
cord-018804-wj35q88f	278	34	which	which	WDT
cord-018804-wj35q88f	278	35	after	after	IN
cord-018804-wj35q88f	278	36	several	several	JJ
cord-018804-wj35q88f	278	37	replication	replication	NN
cord-018804-wj35q88f	278	38	rounds	round	NNS
cord-018804-wj35q88f	278	39	gives	give	VBZ
cord-018804-wj35q88f	278	40	rise	rise	NN
cord-018804-wj35q88f	278	41	to	to	IN
cord-018804-wj35q88f	278	42	a	a	DT
cord-018804-wj35q88f	278	43	progeny	progeny	NN
cord-018804-wj35q88f	278	44	.	.	.
cord-018804-wj35q88f	279	1	Since	since	IN
cord-018804-wj35q88f	279	2	at	at	IN
cord-018804-wj35q88f	279	3	each	each	DT
cord-018804-wj35q88f	279	4	transfer	transfer	NN
cord-018804-wj35q88f	279	5	the	the	DT
cord-018804-wj35q88f	279	6	effective	effective	JJ
cord-018804-wj35q88f	279	7	population	population	NN
cord-018804-wj35q88f	279	8	size	size	NN
cord-018804-wj35q88f	279	9	is	be	VBZ
cord-018804-wj35q88f	279	10	reduced	reduce	VBN
cord-018804-wj35q88f	279	11	to	to	IN
cord-018804-wj35q88f	279	12	one	one	CD
cord-018804-wj35q88f	279	13	individual	individual	NN
cord-018804-wj35q88f	279	14	,	,	,
cord-018804-wj35q88f	279	15	this	this	DT
cord-018804-wj35q88f	279	16	constitutes	constitute	VBZ
cord-018804-wj35q88f	279	17	the	the	DT
cord-018804-wj35q88f	279	18	most	most	RBS
cord-018804-wj35q88f	279	19	extreme	extreme	JJ
cord-018804-wj35q88f	279	20	form	form	NN
cord-018804-wj35q88f	279	21	of	of	IN
cord-018804-wj35q88f	279	22	bottleneck	bottleneck	NN
cord-018804-wj35q88f	279	23	.	.	.
cord-018804-wj35q88f	280	1	The	the	DT
cord-018804-wj35q88f	280	2	population	population	NN
cord-018804-wj35q88f	280	3	contained	contain	VBD
cord-018804-wj35q88f	280	4	in	in	IN
cord-018804-wj35q88f	280	5	a	a	DT
cord-018804-wj35q88f	280	6	randomly	randomly	RB
cord-018804-wj35q88f	280	7	chosen	choose	VBN
cord-018804-wj35q88f	280	8	plaque	plaque	NN
cord-018804-wj35q88f	280	9	is	be	VBZ
cord-018804-wj35q88f	280	10	isolated	isolate	VBN
cord-018804-wj35q88f	280	11	,	,	,
cord-018804-wj35q88f	280	12	properly	properly	RB
cord-018804-wj35q88f	280	13	diluted	dilute	VBN
cord-018804-wj35q88f	280	14	and	and	CC
cord-018804-wj35q88f	280	15	plated	plate	VBN
cord-018804-wj35q88f	280	16	again	again	RB
cord-018804-wj35q88f	280	17	in	in	IN
cord-018804-wj35q88f	280	18	a	a	DT
cord-018804-wj35q88f	280	19	process	process	NN
cord-018804-wj35q88f	280	20	that	that	WDT
cord-018804-wj35q88f	280	21	is	be	VBZ
cord-018804-wj35q88f	280	22	serially	serially	RB
cord-018804-wj35q88f	280	23	repeated	repeat	VBN
cord-018804-wj35q88f	280	24	.	.	.
cord-018804-wj35q88f	281	1	The	the	DT
cord-018804-wj35q88f	281	2	consequences	consequence	NNS
cord-018804-wj35q88f	281	3	on	on	IN
cord-018804-wj35q88f	281	4	fitness	fitness	NN
cord-018804-wj35q88f	281	5	of	of	IN
cord-018804-wj35q88f	281	6	successive	successive	JJ
cord-018804-wj35q88f	281	7	repetitions	repetition	NNS
cord-018804-wj35q88f	281	8	of	of	IN
cord-018804-wj35q88f	281	9	this	this	DT
cord-018804-wj35q88f	281	10	process	process	NN
cord-018804-wj35q88f	281	11	have	have	VBP
cord-018804-wj35q88f	281	12	been	be	VBN
cord-018804-wj35q88f	281	13	analyzed	analyze	VBN
cord-018804-wj35q88f	281	14	with	with	IN
cord-018804-wj35q88f	281	15	several	several	JJ
cord-018804-wj35q88f	281	16	RNA	RNA	NNP
cord-018804-wj35q88f	281	17	viruses	virus	NNS
cord-018804-wj35q88f	281	18	including	include	VBG
cord-018804-wj35q88f	281	19	bacteriophages	bacteriophage	NNS
cord-018804-wj35q88f	281	20	MS2	MS2	NNP
cord-018804-wj35q88f	281	21	[	[	-LRB-
cord-018804-wj35q88f	281	22	62	62	CD
cord-018804-wj35q88f	281	23	]	]	-RRB-
cord-018804-wj35q88f	281	24	and	and	CC
cord-018804-wj35q88f	281	25	Phi	Phi	NNP
cord-018804-wj35q88f	281	26	6	6	CD
cord-018804-wj35q88f	281	27	[	[	-LRB-
cord-018804-wj35q88f	281	28	63	63	CD
cord-018804-wj35q88f	281	29	]	]	-RRB-
cord-018804-wj35q88f	281	30	,	,	,
cord-018804-wj35q88f	281	31	vesicular	vesicular	JJ
cord-018804-wj35q88f	281	32	estomatitis	estomatitis	NN
cord-018804-wj35q88f	281	33	virus	virus	NN
cord-018804-wj35q88f	281	34	(	(	-LRB-
cord-018804-wj35q88f	281	35	VSV	VSV	NNP
cord-018804-wj35q88f	281	36	)	)	-RRB-
cord-018804-wj35q88f	281	37	[	[	-LRB-
cord-018804-wj35q88f	281	38	64	64	CD
cord-018804-wj35q88f	281	39	]	]	-RRB-
cord-018804-wj35q88f	281	40	[	[	-LRB-
cord-018804-wj35q88f	281	41	65	65	CD
cord-018804-wj35q88f	281	42	]	]	-RRB-
cord-018804-wj35q88f	282	1	[	[	-LRB-
cord-018804-wj35q88f	282	2	66	66	CD
cord-018804-wj35q88f	282	3	]	]	-RRB-
cord-018804-wj35q88f	282	4	,	,	.
cord-018804-wj35q88f	283	1	FMDV	FMDV	NNP
cord-018804-wj35q88f	283	2	[	[	-LRB-
cord-018804-wj35q88f	283	3	67	67	CD
cord-018804-wj35q88f	283	4	]	]	-RRB-
cord-018804-wj35q88f	284	1	[	[	-LRB-
cord-018804-wj35q88f	284	2	68	68	CD
cord-018804-wj35q88f	284	3	]	]	-RRB-
cord-018804-wj35q88f	285	1	[	[	-LRB-
cord-018804-wj35q88f	285	2	69	69	CD
cord-018804-wj35q88f	285	3	]	]	-RRB-
cord-018804-wj35q88f	285	4	and	and	CC
cord-018804-wj35q88f	285	5	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	285	6	[	[	-LRB-
cord-018804-wj35q88f	285	7	70	70	CD
cord-018804-wj35q88f	285	8	]	]	-RRB-
cord-018804-wj35q88f	285	9	.	.	.
cord-018804-wj35q88f	286	1	In	in	IN
cord-018804-wj35q88f	286	2	all	all	PDT
cord-018804-wj35q88f	286	3	these	these	DT
cord-018804-wj35q88f	286	4	studies	study	NNS
cord-018804-wj35q88f	286	5	,	,	,
cord-018804-wj35q88f	286	6	progressive	progressive	JJ
cord-018804-wj35q88f	286	7	fitness	fitness	NN
cord-018804-wj35q88f	286	8	declines	decline	NNS
cord-018804-wj35q88f	286	9	were	be	VBD
cord-018804-wj35q88f	286	10	found	find	VBN
cord-018804-wj35q88f	286	11	,	,	,
cord-018804-wj35q88f	286	12	although	although	IN
cord-018804-wj35q88f	286	13	extinctions	extinction	NNS
cord-018804-wj35q88f	286	14	of	of	IN
cord-018804-wj35q88f	286	15	infectivity	infectivity	NN
cord-018804-wj35q88f	286	16	were	be	VBD
cord-018804-wj35q88f	286	17	only	only	RB
cord-018804-wj35q88f	286	18	observed	observe	VBN
cord-018804-wj35q88f	286	19	in	in	IN
cord-018804-wj35q88f	286	20	the	the	DT
cord-018804-wj35q88f	286	21	case	case	NN
cord-018804-wj35q88f	286	22	of	of	IN
cord-018804-wj35q88f	286	23	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	286	24	.	.	.
cord-018804-wj35q88f	287	1	The	the	DT
cord-018804-wj35q88f	287	2	most	most	RBS
cord-018804-wj35q88f	287	3	complete	complete	JJ
cord-018804-wj35q88f	287	4	study	study	NN
cord-018804-wj35q88f	287	5	on	on	IN
cord-018804-wj35q88f	287	6	the	the	DT
cord-018804-wj35q88f	287	7	effect	effect	NN
cord-018804-wj35q88f	287	8	that	that	IN
cord-018804-wj35q88f	287	9	the	the	DT
cord-018804-wj35q88f	287	10	accumulation	accumulation	NN
cord-018804-wj35q88f	287	11	of	of	IN
cord-018804-wj35q88f	287	12	mutations	mutation	NNS
cord-018804-wj35q88f	287	13	through	through	IN
cord-018804-wj35q88f	287	14	plaque	plaque	NN
cord-018804-wj35q88f	287	15	-	-	HYPH
cord-018804-wj35q88f	287	16	to	to	IN
cord-018804-wj35q88f	287	17	-	-	HYPH
cord-018804-wj35q88f	287	18	plaque	plaque	NN
cord-018804-wj35q88f	287	19	transfers	transfer	NNS
cord-018804-wj35q88f	287	20	has	have	VBZ
cord-018804-wj35q88f	287	21	on	on	IN
cord-018804-wj35q88f	287	22	fitness	fitness	NN
cord-018804-wj35q88f	287	23	evolution	evolution	NN
cord-018804-wj35q88f	287	24	has	have	VBZ
cord-018804-wj35q88f	287	25	been	be	VBN
cord-018804-wj35q88f	287	26	carried	carry	VBN
cord-018804-wj35q88f	287	27	out	out	RP
cord-018804-wj35q88f	287	28	with	with	IN
cord-018804-wj35q88f	287	29	FMDV	FMDV	NNP
cord-018804-wj35q88f	287	30	[	[	-LRB-
cord-018804-wj35q88f	287	31	67	67	CD
cord-018804-wj35q88f	287	32	]	]	-RRB-
cord-018804-wj35q88f	287	33	[	[	-LRB-
cord-018804-wj35q88f	287	34	68	68	CD
cord-018804-wj35q88f	287	35	]	]	-RRB-
cord-018804-wj35q88f	287	36	[	[	-LRB-
cord-018804-wj35q88f	287	37	69	69	CD
cord-018804-wj35q88f	287	38	]	]	-RRB-
cord-018804-wj35q88f	287	39	71	71	CD
cord-018804-wj35q88f	287	40	]	]	-RRB-
cord-018804-wj35q88f	287	41	.	.	.
cord-018804-wj35q88f	288	1	In	in	IN
cord-018804-wj35q88f	288	2	this	this	DT
cord-018804-wj35q88f	288	3	study	study	NN
cord-018804-wj35q88f	288	4	,	,	,
cord-018804-wj35q88f	288	5	the	the	DT
cord-018804-wj35q88f	288	6	titer	titer	NN
cord-018804-wj35q88f	288	7	of	of	IN
cord-018804-wj35q88f	288	8	the	the	DT
cord-018804-wj35q88f	288	9	plaques	plaque	NNS
cord-018804-wj35q88f	288	10	(	(	-LRB-
cord-018804-wj35q88f	288	11	determined	determine	VBN
cord-018804-wj35q88f	288	12	as	as	IN
cord-018804-wj35q88f	288	13	the	the	DT
cord-018804-wj35q88f	288	14	number	number	NN
cord-018804-wj35q88f	288	15	of	of	IN
cord-018804-wj35q88f	288	16	infectious	infectious	JJ
cord-018804-wj35q88f	288	17	units	unit	NNS
cord-018804-wj35q88f	288	18	per	per	IN
cord-018804-wj35q88f	288	19	plaque	plaque	NN
cord-018804-wj35q88f	288	20	or	or	CC
cord-018804-wj35q88f	288	21	pfu	pfu	NN
cord-018804-wj35q88f	288	22	)	)	-RRB-
cord-018804-wj35q88f	288	23	at	at	IN
cord-018804-wj35q88f	288	24	each	each	DT
cord-018804-wj35q88f	288	25	transfer	transfer	NN
cord-018804-wj35q88f	288	26	was	be	VBD
cord-018804-wj35q88f	288	27	taken	take	VBN
cord-018804-wj35q88f	288	28	as	as	IN
cord-018804-wj35q88f	288	29	a	a	DT
cord-018804-wj35q88f	288	30	measure	measure	NN
cord-018804-wj35q88f	288	31	of	of	IN
cord-018804-wj35q88f	288	32	fitness	fitness	NN
cord-018804-wj35q88f	288	33	.	.	.
cord-018804-wj35q88f	289	1	The	the	DT
cord-018804-wj35q88f	289	2	mutations	mutation	NNS
cord-018804-wj35q88f	289	3	that	that	WDT
cord-018804-wj35q88f	289	4	accumulated	accumulate	VBD
cord-018804-wj35q88f	289	5	along	along	IN
cord-018804-wj35q88f	289	6	the	the	DT
cord-018804-wj35q88f	289	7	process	process	NN
cord-018804-wj35q88f	289	8	were	be	VBD
cord-018804-wj35q88f	289	9	identified	identify	VBN
cord-018804-wj35q88f	289	10	by	by	IN
cord-018804-wj35q88f	289	11	determining	determine	VBG
cord-018804-wj35q88f	289	12	the	the	DT
cord-018804-wj35q88f	289	13	consensus	consensus	NN
cord-018804-wj35q88f	289	14	sequence	sequence	NN
cord-018804-wj35q88f	289	15	of	of	IN
cord-018804-wj35q88f	289	16	the	the	DT
cord-018804-wj35q88f	289	17	viral	viral	JJ
cord-018804-wj35q88f	289	18	population	population	NN
cord-018804-wj35q88f	289	19	isolated	isolate	VBN
cord-018804-wj35q88f	289	20	from	from	IN
cord-018804-wj35q88f	289	21	single	single	JJ
cord-018804-wj35q88f	289	22	plaques	plaque	NNS
cord-018804-wj35q88f	289	23	at	at	IN
cord-018804-wj35q88f	289	24	different	different	JJ
cord-018804-wj35q88f	289	25	transfers	transfer	NNS
cord-018804-wj35q88f	289	26	.	.	.
cord-018804-wj35q88f	290	1	The	the	DT
cord-018804-wj35q88f	290	2	expected	expected	JJ
cord-018804-wj35q88f	290	3	result	result	NN
cord-018804-wj35q88f	290	4	of	of	IN
cord-018804-wj35q88f	290	5	the	the	DT
cord-018804-wj35q88f	290	6	experiment	experiment	NN
cord-018804-wj35q88f	290	7	was	be	VBD
cord-018804-wj35q88f	290	8	a	a	DT
cord-018804-wj35q88f	290	9	progressive	progressive	JJ
cord-018804-wj35q88f	290	10	decrease	decrease	NN
cord-018804-wj35q88f	290	11	in	in	IN
cord-018804-wj35q88f	290	12	fitness	fitness	NN
cord-018804-wj35q88f	290	13	accompanied	accompany	VBN
cord-018804-wj35q88f	290	14	by	by	IN
cord-018804-wj35q88f	290	15	an	an	DT
cord-018804-wj35q88f	290	16	increase	increase	NN
cord-018804-wj35q88f	290	17	in	in	IN
cord-018804-wj35q88f	290	18	the	the	DT
cord-018804-wj35q88f	290	19	number	number	NN
cord-018804-wj35q88f	290	20	of	of	IN
cord-018804-wj35q88f	290	21	mutations	mutation	NNS
cord-018804-wj35q88f	290	22	fixed	fix	VBN
cord-018804-wj35q88f	290	23	in	in	IN
cord-018804-wj35q88f	290	24	the	the	DT
cord-018804-wj35q88f	290	25	consensus	consensus	NN
cord-018804-wj35q88f	290	26	sequence	sequence	NN
cord-018804-wj35q88f	290	27	.	.	.
cord-018804-wj35q88f	291	1	After	after	IN
cord-018804-wj35q88f	291	2	a	a	DT
cord-018804-wj35q88f	291	3	certain	certain	JJ
cord-018804-wj35q88f	291	4	number	number	NN
cord-018804-wj35q88f	291	5	of	of	IN
cord-018804-wj35q88f	291	6	transfers	transfer	NNS
cord-018804-wj35q88f	291	7	,	,	,
cord-018804-wj35q88f	291	8	extinctions	extinction	NNS
cord-018804-wj35q88f	291	9	of	of	IN
cord-018804-wj35q88f	291	10	infectivity	infectivity	NN
cord-018804-wj35q88f	291	11	were	be	VBD
cord-018804-wj35q88f	291	12	expected	expect	VBN
cord-018804-wj35q88f	291	13	.	.	.
cord-018804-wj35q88f	292	1	In	in	IN
cord-018804-wj35q88f	292	2	contrast	contrast	NN
cord-018804-wj35q88f	292	3	to	to	IN
cord-018804-wj35q88f	292	4	these	these	DT
cord-018804-wj35q88f	292	5	expectations	expectation	NNS
cord-018804-wj35q88f	292	6	,	,	,
cord-018804-wj35q88f	292	7	a	a	DT
cord-018804-wj35q88f	292	8	biphasic	biphasic	JJ
cord-018804-wj35q88f	292	9	dynamics	dynamic	NNS
cord-018804-wj35q88f	292	10	of	of	IN
cord-018804-wj35q88f	292	11	fitness	fitness	NN
cord-018804-wj35q88f	292	12	decrease	decrease	NN
cord-018804-wj35q88f	292	13	was	be	VBD
cord-018804-wj35q88f	292	14	observed	observe	VBN
cord-018804-wj35q88f	292	15	.	.	.
cord-018804-wj35q88f	293	1	There	there	EX
cord-018804-wj35q88f	293	2	was	be	VBD
cord-018804-wj35q88f	293	3	an	an	DT
cord-018804-wj35q88f	293	4	initial	initial	JJ
cord-018804-wj35q88f	293	5	period	period	NN
cord-018804-wj35q88f	293	6	of	of	IN
cord-018804-wj35q88f	293	7	roughly	roughly	RB
cord-018804-wj35q88f	293	8	exponential	exponential	JJ
cord-018804-wj35q88f	293	9	fitness	fitness	NN
cord-018804-wj35q88f	293	10	loss	loss	NN
cord-018804-wj35q88f	293	11	,	,	,
cord-018804-wj35q88f	293	12	but	but	CC
cord-018804-wj35q88f	293	13	after	after	IN
cord-018804-wj35q88f	293	14	a	a	DT
cord-018804-wj35q88f	293	15	variable	variable	JJ
cord-018804-wj35q88f	293	16	number	number	NN
cord-018804-wj35q88f	293	17	of	of	IN
cord-018804-wj35q88f	293	18	passages	passage	NNS
cord-018804-wj35q88f	293	19	,	,	,
cord-018804-wj35q88f	293	20	a	a	DT
cord-018804-wj35q88f	293	21	statistically	statistically	RB
cord-018804-wj35q88f	293	22	stationary	stationary	JJ
cord-018804-wj35q88f	293	23	state	state	NN
cord-018804-wj35q88f	293	24	of	of	IN
cord-018804-wj35q88f	293	25	fitness	fitness	NN
cord-018804-wj35q88f	293	26	with	with	IN
cord-018804-wj35q88f	293	27	large	large	JJ
cord-018804-wj35q88f	293	28	fluctuations	fluctuation	NNS
cord-018804-wj35q88f	293	29	around	around	IN
cord-018804-wj35q88f	293	30	a	a	DT
cord-018804-wj35q88f	293	31	mean	mean	JJ
cord-018804-wj35q88f	293	32	constant	constant	JJ
cord-018804-wj35q88f	293	33	value	value	NN
cord-018804-wj35q88f	293	34	was	be	VBD
cord-018804-wj35q88f	293	35	reached	reach	VBN
cord-018804-wj35q88f	293	36	(	(	-LRB-
cord-018804-wj35q88f	293	37	Fig	Fig	NNP
cord-018804-wj35q88f	293	38	.	.	.
cord-018804-wj35q88f	293	39	15.4	15.4	CD
cord-018804-wj35q88f	293	40	)	)	-RRB-
cord-018804-wj35q88f	293	41	.	.	.
cord-018804-wj35q88f	294	1	In	in	IN
cord-018804-wj35q88f	294	2	this	this	DT
cord-018804-wj35q88f	294	3	state	state	NN
cord-018804-wj35q88f	294	4	,	,	,
cord-018804-wj35q88f	294	5	the	the	DT
cord-018804-wj35q88f	294	6	virus	virus	NN
cord-018804-wj35q88f	294	7	exhibits	exhibit	VBZ
cord-018804-wj35q88f	294	8	a	a	DT
cord-018804-wj35q88f	294	9	great	great	JJ
cord-018804-wj35q88f	294	10	resistance	resistance	NN
cord-018804-wj35q88f	294	11	to	to	IN
cord-018804-wj35q88f	294	12	extinction	extinction	NN
cord-018804-wj35q88f	294	13	,	,	,
cord-018804-wj35q88f	294	14	since	since	IN
cord-018804-wj35q88f	294	15	when	when	WRB
cord-018804-wj35q88f	294	16	it	-PRON-	PRP
cord-018804-wj35q88f	294	17	reaches	reach	VBZ
cord-018804-wj35q88f	294	18	a	a	DT
cord-018804-wj35q88f	294	19	very	very	RB
cord-018804-wj35q88f	294	20	low	low	JJ
cord-018804-wj35q88f	294	21	fitness	fitness	NN
cord-018804-wj35q88f	294	22	value	value	NN
cord-018804-wj35q88f	294	23	,	,	,
cord-018804-wj35q88f	294	24	the	the	DT
cord-018804-wj35q88f	294	25	usual	usual	JJ
cord-018804-wj35q88f	294	26	outcome	outcome	NN
cord-018804-wj35q88f	294	27	at	at	IN
cord-018804-wj35q88f	294	28	the	the	DT
cord-018804-wj35q88f	294	29	next	next	JJ
cord-018804-wj35q88f	294	30	passage	passage	NN
cord-018804-wj35q88f	294	31	is	be	VBZ
cord-018804-wj35q88f	294	32	a	a	DT
cord-018804-wj35q88f	294	33	sudden	sudden	JJ
cord-018804-wj35q88f	294	34	fitness	fitness	NN
cord-018804-wj35q88f	294	35	recovery	recovery	NN
cord-018804-wj35q88f	294	36	.	.	.
cord-018804-wj35q88f	295	1	A	a	DT
cord-018804-wj35q88f	295	2	detailed	detailed	JJ
cord-018804-wj35q88f	295	3	statistical	statistical	JJ
cord-018804-wj35q88f	295	4	analysis	analysis	NN
cord-018804-wj35q88f	295	5	of	of	IN
cord-018804-wj35q88f	295	6	the	the	DT
cord-018804-wj35q88f	295	7	viral	viral	JJ
cord-018804-wj35q88f	295	8	titers	titer	NNS
cord-018804-wj35q88f	295	9	at	at	IN
cord-018804-wj35q88f	295	10	the	the	DT
cord-018804-wj35q88f	295	11	stationary	stationary	JJ
cord-018804-wj35q88f	295	12	state	state	NN
cord-018804-wj35q88f	295	13	showed	show	VBD
cord-018804-wj35q88f	295	14	that	that	IN
cord-018804-wj35q88f	295	15	fluctuations	fluctuation	NNS
cord-018804-wj35q88f	295	16	in	in	IN
cord-018804-wj35q88f	295	17	the	the	DT
cord-018804-wj35q88f	295	18	viral	viral	JJ
cord-018804-wj35q88f	295	19	yield	yield	NN
cord-018804-wj35q88f	295	20	followed	follow	VBD
cord-018804-wj35q88f	295	21	a	a	DT
cord-018804-wj35q88f	295	22	Weibull	Weibull	NNP
cord-018804-wj35q88f	295	23	distribution	distribution	NN
cord-018804-wj35q88f	295	24	[	[	-LRB-
cord-018804-wj35q88f	295	25	69	69	CD
cord-018804-wj35q88f	295	26	]	]	-RRB-
cord-018804-wj35q88f	295	27	.	.	.
cord-018804-wj35q88f	296	1	This	this	DT
cord-018804-wj35q88f	296	2	distribution	distribution	NN
cord-018804-wj35q88f	296	3	is	be	VBZ
cord-018804-wj35q88f	296	4	indicative	indicative	JJ
cord-018804-wj35q88f	296	5	of	of	IN
cord-018804-wj35q88f	296	6	an	an	DT
cord-018804-wj35q88f	296	7	underlying	underlie	VBG
cord-018804-wj35q88f	296	8	dynamics	dynamic	NNS
cord-018804-wj35q88f	296	9	with	with	IN
cord-018804-wj35q88f	296	10	two	two	CD
cord-018804-wj35q88f	296	11	main	main	JJ
cord-018804-wj35q88f	296	12	features	feature	NNS
cord-018804-wj35q88f	296	13	(	(	-LRB-
cord-018804-wj35q88f	296	14	a	a	LS
cord-018804-wj35q88f	296	15	)	)	-RRB-
cord-018804-wj35q88f	296	16	an	an	DT
cord-018804-wj35q88f	296	17	exponential	exponential	JJ
cord-018804-wj35q88f	296	18	amplification	amplification	NN
cord-018804-wj35q88f	296	19	of	of	IN
cord-018804-wj35q88f	296	20	the	the	DT
cord-018804-wj35q88f	296	21	founder	founder	NN
cord-018804-wj35q88f	296	22	genomes	genome	NNS
cord-018804-wj35q88f	296	23	during	during	IN
cord-018804-wj35q88f	296	24	the	the	DT
cord-018804-wj35q88f	296	25	development	development	NN
cord-018804-wj35q88f	296	26	of	of	IN
cord-018804-wj35q88f	296	27	each	each	DT
cord-018804-wj35q88f	296	28	plaque	plaque	NN
cord-018804-wj35q88f	296	29	,	,	,
cord-018804-wj35q88f	296	30	which	which	WDT
cord-018804-wj35q88f	296	31	makes	make	VBZ
cord-018804-wj35q88f	296	32	that	that	DT
cord-018804-wj35q88f	296	33	small	small	JJ
cord-018804-wj35q88f	296	34	fitness	fitness	NN
cord-018804-wj35q88f	296	35	differences	difference	NNS
cord-018804-wj35q88f	296	36	are	be	VBP
cord-018804-wj35q88f	296	37	considerably	considerably	RB
cord-018804-wj35q88f	296	38	amplified	amplify	VBN
cord-018804-wj35q88f	296	39	and	and	CC
cord-018804-wj35q88f	296	40	(	(	-LRB-
cord-018804-wj35q88f	296	41	b	b	LS
cord-018804-wj35q88f	296	42	)	)	-RRB-
cord-018804-wj35q88f	296	43	large	large	JJ
cord-018804-wj35q88f	296	44	variations	variation	NNS
cord-018804-wj35q88f	296	45	in	in	IN
cord-018804-wj35q88f	296	46	the	the	DT
cord-018804-wj35q88f	296	47	initial	initial	JJ
cord-018804-wj35q88f	296	48	state	state	NN
cord-018804-wj35q88f	296	49	of	of	IN
cord-018804-wj35q88f	296	50	the	the	DT
cord-018804-wj35q88f	296	51	system	system	NN
cord-018804-wj35q88f	296	52	at	at	IN
cord-018804-wj35q88f	296	53	each	each	DT
cord-018804-wj35q88f	296	54	transfer	transfer	NN
cord-018804-wj35q88f	296	55	,	,	,
cord-018804-wj35q88f	296	56	which	which	WDT
cord-018804-wj35q88f	296	57	is	be	VBZ
cord-018804-wj35q88f	296	58	determined	determine	VBN
cord-018804-wj35q88f	296	59	by	by	IN
cord-018804-wj35q88f	296	60	the	the	DT
cord-018804-wj35q88f	296	61	stochastic	stochastic	JJ
cord-018804-wj35q88f	296	62	nature	nature	NN
cord-018804-wj35q88f	296	63	of	of	IN
cord-018804-wj35q88f	296	64	the	the	DT
cord-018804-wj35q88f	296	65	sampling	sampling	NN
cord-018804-wj35q88f	296	66	process	process	NN
cord-018804-wj35q88f	296	67	.	.	.
cord-018804-wj35q88f	297	1	Strikingly	strikingly	RB
cord-018804-wj35q88f	297	2	,	,	,
cord-018804-wj35q88f	297	3	mutations	mutation	NNS
cord-018804-wj35q88f	297	4	accumulated	accumulate	VBN
cord-018804-wj35q88f	297	5	at	at	IN
cord-018804-wj35q88f	297	6	the	the	DT
cord-018804-wj35q88f	297	7	same	same	JJ
cord-018804-wj35q88f	297	8	rate	rate	NN
cord-018804-wj35q88f	297	9	in	in	IN
cord-018804-wj35q88f	297	10	the	the	DT
cord-018804-wj35q88f	297	11	phase	phase	NN
cord-018804-wj35q88f	297	12	of	of	IN
cord-018804-wj35q88f	297	13	fitness	fitness	NN
cord-018804-wj35q88f	297	14	decrease	decrease	NN
cord-018804-wj35q88f	297	15	and	and	CC
cord-018804-wj35q88f	297	16	in	in	IN
cord-018804-wj35q88f	297	17	the	the	DT
cord-018804-wj35q88f	297	18	stationary	stationary	JJ
cord-018804-wj35q88f	297	19	state	state	NN
cord-018804-wj35q88f	297	20	[	[	-LRB-
cord-018804-wj35q88f	297	21	68	68	CD
cord-018804-wj35q88f	297	22	]	]	-RRB-
cord-018804-wj35q88f	297	23	.	.	.
cord-018804-wj35q88f	298	1	This	this	DT
cord-018804-wj35q88f	298	2	might	may	MD
cord-018804-wj35q88f	298	3	indicate	indicate	VB
cord-018804-wj35q88f	298	4	that	that	IN
cord-018804-wj35q88f	298	5	the	the	DT
cord-018804-wj35q88f	298	6	nature	nature	NN
cord-018804-wj35q88f	298	7	and	and	CC
cord-018804-wj35q88f	298	8	effects	effect	NNS
cord-018804-wj35q88f	298	9	of	of	IN
cord-018804-wj35q88f	298	10	mutations	mutation	NNS
cord-018804-wj35q88f	298	11	can	can	MD
cord-018804-wj35q88f	298	12	vary	vary	VB
cord-018804-wj35q88f	298	13	with	with	IN
cord-018804-wj35q88f	298	14	the	the	DT
cord-018804-wj35q88f	298	15	transfer	transfer	NN
cord-018804-wj35q88f	298	16	number	number	NN
cord-018804-wj35q88f	298	17	,	,	,
cord-018804-wj35q88f	298	18	depending	depend	VBG
cord-018804-wj35q88f	298	19	on	on	IN
cord-018804-wj35q88f	298	20	the	the	DT
cord-018804-wj35q88f	298	21	restrictions	restriction	NNS
cord-018804-wj35q88f	298	22	imposed	impose	VBN
cord-018804-wj35q88f	298	23	by	by	IN
cord-018804-wj35q88f	298	24	the	the	DT
cord-018804-wj35q88f	298	25	selection	selection	NN
cord-018804-wj35q88f	298	26	of	of	IN
cord-018804-wj35q88f	298	27	the	the	DT
cord-018804-wj35q88f	298	28	genomes	genome	NNS
cord-018804-wj35q88f	298	29	able	able	JJ
cord-018804-wj35q88f	298	30	to	to	TO
cord-018804-wj35q88f	298	31	form	form	VB
cord-018804-wj35q88f	298	32	plaques	plaque	NNS
cord-018804-wj35q88f	298	33	.	.	.
cord-018804-wj35q88f	299	1	When	when	WRB
cord-018804-wj35q88f	299	2	the	the	DT
cord-018804-wj35q88f	299	3	population	population	NN
cord-018804-wj35q88f	299	4	is	be	VBZ
cord-018804-wj35q88f	299	5	well	well	RB
cord-018804-wj35q88f	299	6	adapted	adapt	VBN
cord-018804-wj35q88f	299	7	to	to	IN
cord-018804-wj35q88f	299	8	the	the	DT
cord-018804-wj35q88f	299	9	environment	environment	NN
cord-018804-wj35q88f	299	10	,	,	,
cord-018804-wj35q88f	299	11	as	as	IN
cord-018804-wj35q88f	299	12	it	-PRON-	PRP
cord-018804-wj35q88f	299	13	happens	happen	VBZ
cord-018804-wj35q88f	299	14	at	at	IN
cord-018804-wj35q88f	299	15	the	the	DT
cord-018804-wj35q88f	299	16	beginning	beginning	NN
cord-018804-wj35q88f	299	17	of	of	IN
cord-018804-wj35q88f	299	18	the	the	DT
cord-018804-wj35q88f	299	19	experiment	experiment	NN
cord-018804-wj35q88f	299	20	,	,	,
cord-018804-wj35q88f	299	21	deleterious	deleterious	JJ
cord-018804-wj35q88f	299	22	mutations	mutation	NNS
cord-018804-wj35q88f	299	23	are	be	VBP
cord-018804-wj35q88f	299	24	well	well	RB
cord-018804-wj35q88f	299	25	tolerated	tolerate	VBN
cord-018804-wj35q88f	299	26	.	.	.
cord-018804-wj35q88f	300	1	However	however	RB
cord-018804-wj35q88f	300	2	,	,	,
cord-018804-wj35q88f	300	3	as	as	IN
cord-018804-wj35q88f	300	4	the	the	DT
cord-018804-wj35q88f	300	5	population	population	NN
cord-018804-wj35q88f	300	6	is	be	VBZ
cord-018804-wj35q88f	300	7	getting	get	VBG
cord-018804-wj35q88f	300	8	more	more	RBR
cord-018804-wj35q88f	300	9	debilitated	debilitated	JJ
cord-018804-wj35q88f	300	10	,	,	,
cord-018804-wj35q88f	300	11	less	less	RBR
cord-018804-wj35q88f	300	12	deleterious	deleterious	JJ
cord-018804-wj35q88f	300	13	mutations	mutation	NNS
cord-018804-wj35q88f	300	14	can	can	MD
cord-018804-wj35q88f	300	15	be	be	VB
cord-018804-wj35q88f	300	16	accepted	accept	VBN
cord-018804-wj35q88f	300	17	and	and	CC
cord-018804-wj35q88f	300	18	possibly	possibly	RB
cord-018804-wj35q88f	300	19	there	there	EX
cord-018804-wj35q88f	300	20	are	be	VBP
cord-018804-wj35q88f	300	21	many	many	JJ
cord-018804-wj35q88f	300	22	extinctions	extinction	NNS
cord-018804-wj35q88f	300	23	of	of	IN
cord-018804-wj35q88f	300	24	individual	individual	JJ
cord-018804-wj35q88f	300	25	genomes	genome	NNS
cord-018804-wj35q88f	300	26	Fig	Fig	NNP
cord-018804-wj35q88f	300	27	.	.	.
cord-018804-wj35q88f	301	1	15.4	15.4	CD
cord-018804-wj35q88f	301	2	.	.	.
cord-018804-wj35q88f	302	1	Infectious	infectious	JJ
cord-018804-wj35q88f	302	2	units	unit	NNS
cord-018804-wj35q88f	302	3	per	per	IN
cord-018804-wj35q88f	302	4	plaque	plaque	NN
cord-018804-wj35q88f	302	5	produced	produce	VBN
cord-018804-wj35q88f	302	6	along	along	IN
cord-018804-wj35q88f	302	7	the	the	DT
cord-018804-wj35q88f	302	8	process	process	NN
cord-018804-wj35q88f	302	9	of	of	IN
cord-018804-wj35q88f	302	10	plaque	plaque	NN
cord-018804-wj35q88f	302	11	-	-	HYPH
cord-018804-wj35q88f	302	12	toplaque	toplaque	NN
cord-018804-wj35q88f	302	13	transfers	transfer	NNS
cord-018804-wj35q88f	302	14	experienced	experience	VBN
cord-018804-wj35q88f	302	15	by	by	IN
cord-018804-wj35q88f	302	16	the	the	DT
cord-018804-wj35q88f	302	17	viral	viral	JJ
cord-018804-wj35q88f	302	18	clone	clone	NN
cord-018804-wj35q88f	302	19	C10	C10	NNP
cord-018804-wj35q88f	302	20	.	.	.
cord-018804-wj35q88f	303	1	After	after	IN
cord-018804-wj35q88f	303	2	an	an	DT
cord-018804-wj35q88f	303	3	exponential	exponential	JJ
cord-018804-wj35q88f	303	4	decay	decay	NN
cord-018804-wj35q88f	303	5	of	of	IN
cord-018804-wj35q88f	303	6	infectivity	infectivity	NN
cord-018804-wj35q88f	303	7	,	,	,
cord-018804-wj35q88f	303	8	a	a	DT
cord-018804-wj35q88f	303	9	statistical	statistical	JJ
cord-018804-wj35q88f	303	10	stationary	stationary	JJ
cord-018804-wj35q88f	303	11	state	state	NN
cord-018804-wj35q88f	303	12	with	with	IN
cord-018804-wj35q88f	303	13	strong	strong	JJ
cord-018804-wj35q88f	303	14	fluctuations	fluctuation	NNS
cord-018804-wj35q88f	303	15	is	be	VBZ
cord-018804-wj35q88f	303	16	attained	attain	VBN
cord-018804-wj35q88f	303	17	that	that	WDT
cord-018804-wj35q88f	303	18	become	become	VBP
cord-018804-wj35q88f	303	19	unable	unable	JJ
cord-018804-wj35q88f	303	20	to	to	TO
cord-018804-wj35q88f	303	21	replicate	replicate	VB
cord-018804-wj35q88f	303	22	.	.	.
cord-018804-wj35q88f	304	1	Nevertheless	nevertheless	RB
cord-018804-wj35q88f	304	2	,	,	,
cord-018804-wj35q88f	304	3	a	a	DT
cord-018804-wj35q88f	304	4	fraction	fraction	NN
cord-018804-wj35q88f	304	5	of	of	IN
cord-018804-wj35q88f	304	6	the	the	DT
cord-018804-wj35q88f	304	7	genomes	genome	NNS
cord-018804-wj35q88f	304	8	contained	contain	VBN
cord-018804-wj35q88f	304	9	in	in	IN
cord-018804-wj35q88f	304	10	a	a	DT
cord-018804-wj35q88f	304	11	plaque	plaque	NN
cord-018804-wj35q88f	304	12	can	can	MD
cord-018804-wj35q88f	304	13	possess	possess	VB
cord-018804-wj35q88f	304	14	advantageous	advantageous	JJ
cord-018804-wj35q88f	304	15	mutations	mutation	NNS
cord-018804-wj35q88f	304	16	,	,	,
cord-018804-wj35q88f	304	17	in	in	IN
cord-018804-wj35q88f	304	18	some	some	DT
cord-018804-wj35q88f	304	19	occasions	occasion	NNS
cord-018804-wj35q88f	304	20	because	because	IN
cord-018804-wj35q88f	304	21	the	the	DT
cord-018804-wj35q88f	304	22	mutation	mutation	NN
cord-018804-wj35q88f	304	23	has	have	VBZ
cord-018804-wj35q88f	304	24	a	a	DT
cord-018804-wj35q88f	304	25	positive	positive	JJ
cord-018804-wj35q88f	304	26	effect	effect	NN
cord-018804-wj35q88f	304	27	'	'	''
cord-018804-wj35q88f	304	28	per	per	FW
cord-018804-wj35q88f	304	29	se	se	FW
cord-018804-wj35q88f	304	30	'	'	''
cord-018804-wj35q88f	304	31	and	and	CC
cord-018804-wj35q88f	304	32	in	in	IN
cord-018804-wj35q88f	304	33	others	other	NNS
cord-018804-wj35q88f	304	34	because	because	IN
cord-018804-wj35q88f	304	35	it	-PRON-	PRP
cord-018804-wj35q88f	304	36	has	have	VBZ
cord-018804-wj35q88f	304	37	a	a	DT
cord-018804-wj35q88f	304	38	compensatory	compensatory	JJ
cord-018804-wj35q88f	304	39	effect	effect	NN
cord-018804-wj35q88f	304	40	in	in	IN
cord-018804-wj35q88f	304	41	a	a	DT
cord-018804-wj35q88f	304	42	concrete	concrete	JJ
cord-018804-wj35q88f	304	43	genome	genome	NN
cord-018804-wj35q88f	304	44	carrying	carry	VBG
cord-018804-wj35q88f	304	45	a	a	DT
cord-018804-wj35q88f	304	46	particular	particular	JJ
cord-018804-wj35q88f	304	47	combination	combination	NN
cord-018804-wj35q88f	304	48	of	of	IN
cord-018804-wj35q88f	304	49	mutations	mutation	NNS
cord-018804-wj35q88f	304	50	.	.	.
cord-018804-wj35q88f	305	1	In	in	IN
cord-018804-wj35q88f	305	2	the	the	DT
cord-018804-wj35q88f	305	3	stationary	stationary	JJ
cord-018804-wj35q88f	305	4	state	state	NN
cord-018804-wj35q88f	305	5	,	,	,
cord-018804-wj35q88f	305	6	where	where	WRB
cord-018804-wj35q88f	305	7	average	average	JJ
cord-018804-wj35q88f	305	8	fitness	fitness	NN
cord-018804-wj35q88f	305	9	values	value	NNS
cord-018804-wj35q88f	305	10	possibly	possibly	RB
cord-018804-wj35q88f	305	11	are	be	VBP
cord-018804-wj35q88f	305	12	the	the	DT
cord-018804-wj35q88f	305	13	lowest	low	JJS
cord-018804-wj35q88f	305	14	ones	one	NNS
cord-018804-wj35q88f	305	15	compatible	compatible	JJ
cord-018804-wj35q88f	305	16	with	with	IN
cord-018804-wj35q88f	305	17	virus	virus	NN
cord-018804-wj35q88f	305	18	survival	survival	NN
cord-018804-wj35q88f	305	19	,	,	,
cord-018804-wj35q88f	305	20	advantageous	advantageous	JJ
cord-018804-wj35q88f	305	21	mutations	mutation	NNS
cord-018804-wj35q88f	305	22	would	would	MD
cord-018804-wj35q88f	305	23	be	be	VB
cord-018804-wj35q88f	305	24	more	more	RBR
cord-018804-wj35q88f	305	25	easily	easily	RB
cord-018804-wj35q88f	305	26	selected	select	VBN
cord-018804-wj35q88f	305	27	,	,	,
cord-018804-wj35q88f	305	28	because	because	IN
cord-018804-wj35q88f	305	29	only	only	RB
cord-018804-wj35q88f	305	30	the	the	DT
cord-018804-wj35q88f	305	31	genomes	genome	NNS
cord-018804-wj35q88f	305	32	carrying	carry	VBG
cord-018804-wj35q88f	305	33	them	-PRON-	PRP
cord-018804-wj35q88f	305	34	can	can	MD
cord-018804-wj35q88f	305	35	form	form	VB
cord-018804-wj35q88f	305	36	plaques	plaque	NNS
cord-018804-wj35q88f	305	37	and	and	CC
cord-018804-wj35q88f	305	38	be	be	VB
cord-018804-wj35q88f	305	39	chosen	choose	VBN
cord-018804-wj35q88f	305	40	for	for	IN
cord-018804-wj35q88f	305	41	the	the	DT
cord-018804-wj35q88f	305	42	next	next	JJ
cord-018804-wj35q88f	305	43	transfer	transfer	NN
cord-018804-wj35q88f	305	44	.	.	.
cord-018804-wj35q88f	306	1	Each	each	DT
cord-018804-wj35q88f	306	2	advantageous	advantageous	JJ
cord-018804-wj35q88f	306	3	mutation	mutation	NN
cord-018804-wj35q88f	306	4	produces	produce	VBZ
cord-018804-wj35q88f	306	5	a	a	DT
cord-018804-wj35q88f	306	6	fitness	fitness	NN
cord-018804-wj35q88f	306	7	increase	increase	NN
cord-018804-wj35q88f	306	8	that	that	WDT
cord-018804-wj35q88f	306	9	moves	move	VBZ
cord-018804-wj35q88f	306	10	the	the	DT
cord-018804-wj35q88f	306	11	genome	genome	NN
cord-018804-wj35q88f	306	12	to	to	IN
cord-018804-wj35q88f	306	13	a	a	DT
cord-018804-wj35q88f	306	14	different	different	JJ
cord-018804-wj35q88f	306	15	position	position	NN
cord-018804-wj35q88f	306	16	in	in	IN
cord-018804-wj35q88f	306	17	the	the	DT
cord-018804-wj35q88f	306	18	fitness	fitness	NN
cord-018804-wj35q88f	306	19	landscape	landscape	NN
cord-018804-wj35q88f	306	20	.	.	.
cord-018804-wj35q88f	307	1	This	this	DT
cord-018804-wj35q88f	307	2	permits	permit	VBZ
cord-018804-wj35q88f	307	3	the	the	DT
cord-018804-wj35q88f	307	4	acceptance	acceptance	NN
cord-018804-wj35q88f	307	5	of	of	IN
cord-018804-wj35q88f	307	6	additional	additional	JJ
cord-018804-wj35q88f	307	7	deleterious	deleterious	JJ
cord-018804-wj35q88f	307	8	mutations	mutation	NNS
cord-018804-wj35q88f	307	9	,	,	,
cord-018804-wj35q88f	307	10	originating	originate	VBG
cord-018804-wj35q88f	307	11	the	the	DT
cord-018804-wj35q88f	307	12	fluctuating	fluctuating	JJ
cord-018804-wj35q88f	307	13	pattern	pattern	NN
cord-018804-wj35q88f	307	14	of	of	IN
cord-018804-wj35q88f	307	15	infectivity	infectivity	NN
cord-018804-wj35q88f	307	16	that	that	WDT
cord-018804-wj35q88f	307	17	is	be	VBZ
cord-018804-wj35q88f	307	18	observed	observe	VBN
cord-018804-wj35q88f	307	19	in	in	IN
cord-018804-wj35q88f	307	20	the	the	DT
cord-018804-wj35q88f	307	21	experiments	experiment	NNS
cord-018804-wj35q88f	307	22	.	.	.
cord-018804-wj35q88f	308	1	An	an	DT
cord-018804-wj35q88f	308	2	interesting	interesting	JJ
cord-018804-wj35q88f	308	3	result	result	NN
cord-018804-wj35q88f	308	4	is	be	VBZ
cord-018804-wj35q88f	308	5	the	the	DT
cord-018804-wj35q88f	308	6	preferential	preferential	JJ
cord-018804-wj35q88f	308	7	accumulation	accumulation	NN
cord-018804-wj35q88f	308	8	of	of	IN
cord-018804-wj35q88f	308	9	mutations	mutation	NNS
cord-018804-wj35q88f	308	10	in	in	IN
cord-018804-wj35q88f	308	11	certain	certain	JJ
cord-018804-wj35q88f	308	12	genomic	genomic	JJ
cord-018804-wj35q88f	308	13	regions	region	NNS
cord-018804-wj35q88f	308	14	that	that	WDT
cord-018804-wj35q88f	308	15	present	present	VBP
cord-018804-wj35q88f	308	16	a	a	DT
cord-018804-wj35q88f	308	17	mutation	mutation	NN
cord-018804-wj35q88f	308	18	frequency	frequency	NN
cord-018804-wj35q88f	308	19	significantly	significantly	RB
cord-018804-wj35q88f	308	20	higher	high	JJR
cord-018804-wj35q88f	308	21	than	than	IN
cord-018804-wj35q88f	308	22	the	the	DT
cord-018804-wj35q88f	308	23	average	average	NN
cord-018804-wj35q88f	308	24	obtained	obtain	VBD
cord-018804-wj35q88f	308	25	considering	consider	VBG
cord-018804-wj35q88f	308	26	the	the	DT
cord-018804-wj35q88f	308	27	whole	whole	JJ
cord-018804-wj35q88f	308	28	genome	genome	NN
cord-018804-wj35q88f	308	29	[	[	-LRB-
cord-018804-wj35q88f	308	30	68	68	CD
cord-018804-wj35q88f	308	31	]	]	-RRB-
cord-018804-wj35q88f	309	1	(	(	-LRB-
cord-018804-wj35q88f	309	2	Fig	Fig	NNP
cord-018804-wj35q88f	309	3	.	.	.
cord-018804-wj35q88f	309	4	15.5	15.5	CD
cord-018804-wj35q88f	309	5	)	)	-RRB-
cord-018804-wj35q88f	309	6	.	.	.
cord-018804-wj35q88f	310	1	An	an	DT
cord-018804-wj35q88f	310	2	unusual	unusual	JJ
cord-018804-wj35q88f	310	3	distribution	distribution	NN
cord-018804-wj35q88f	310	4	of	of	IN
cord-018804-wj35q88f	310	5	mutations	mutation	NNS
cord-018804-wj35q88f	310	6	has	have	VBZ
cord-018804-wj35q88f	310	7	also	also	RB
cord-018804-wj35q88f	310	8	been	be	VBN
cord-018804-wj35q88f	310	9	found	find	VBN
cord-018804-wj35q88f	310	10	in	in	IN
cord-018804-wj35q88f	310	11	bottlenecked	bottlenecked	JJ
cord-018804-wj35q88f	310	12	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	310	13	clones	clone	NNS
cord-018804-wj35q88f	310	14	in	in	IN
cord-018804-wj35q88f	310	15	which	which	WDT
cord-018804-wj35q88f	310	16	there	there	EX
cord-018804-wj35q88f	310	17	was	be	VBD
cord-018804-wj35q88f	310	18	a	a	DT
cord-018804-wj35q88f	310	19	higher	high	JJR
cord-018804-wj35q88f	310	20	accumulation	accumulation	NN
cord-018804-wj35q88f	310	21	of	of	IN
cord-018804-wj35q88f	310	22	mutations	mutation	NNS
cord-018804-wj35q88f	310	23	in	in	IN
cord-018804-wj35q88f	310	24	the	the	DT
cord-018804-wj35q88f	310	25	gene	gene	NN
cord-018804-wj35q88f	310	26	gag	gag	NN
cord-018804-wj35q88f	310	27	and	and	CC
cord-018804-wj35q88f	310	28	the	the	DT
cord-018804-wj35q88f	310	29	first	first	JJ
cord-018804-wj35q88f	310	30	third	third	NN
cord-018804-wj35q88f	310	31	of	of	IN
cord-018804-wj35q88f	310	32	the	the	DT
cord-018804-wj35q88f	310	33	genome	genome	NN
cord-018804-wj35q88f	310	34	,	,	,
cord-018804-wj35q88f	310	35	compared	compare	VBN
cord-018804-wj35q88f	310	36	to	to	IN
cord-018804-wj35q88f	310	37	the	the	DT
cord-018804-wj35q88f	310	38	gene	gene	NN
cord-018804-wj35q88f	310	39	env	env	NN
cord-018804-wj35q88f	310	40	,	,	,
cord-018804-wj35q88f	310	41	which	which	WDT
cord-018804-wj35q88f	310	42	is	be	VBZ
cord-018804-wj35q88f	310	43	less	less	RBR
cord-018804-wj35q88f	310	44	conserved	conserve	VBN
cord-018804-wj35q88f	310	45	in	in	IN
cord-018804-wj35q88f	310	46	natural	natural	JJ
cord-018804-wj35q88f	310	47	populations	population	NNS
cord-018804-wj35q88f	310	48	of	of	IN
cord-018804-wj35q88f	310	49	the	the	DT
cord-018804-wj35q88f	310	50	virus	virus	NN
cord-018804-wj35q88f	310	51	[	[	-LRB-
cord-018804-wj35q88f	310	52	73	73	CD
cord-018804-wj35q88f	310	53	]	]	-RRB-
cord-018804-wj35q88f	310	54	.	.	.
cord-018804-wj35q88f	311	1	Bottlenecked	bottlenecked	JJ
cord-018804-wj35q88f	311	2	VSV	VSV	NNP
cord-018804-wj35q88f	311	3	clones	clone	NNS
cord-018804-wj35q88f	311	4	also	also	RB
cord-018804-wj35q88f	311	5	accumulated	accumulate	VBD
cord-018804-wj35q88f	311	6	a	a	DT
cord-018804-wj35q88f	311	7	high	high	JJ
cord-018804-wj35q88f	311	8	number	number	NN
cord-018804-wj35q88f	311	9	of	of	IN
cord-018804-wj35q88f	311	10	mutations	mutation	NNS
cord-018804-wj35q88f	311	11	in	in	IN
cord-018804-wj35q88f	311	12	the	the	DT
cord-018804-wj35q88f	311	13	N	n	CD
cord-018804-wj35q88f	311	14	open	open	JJ
cord-018804-wj35q88f	311	15	reading	reading	NN
cord-018804-wj35q88f	311	16	frame	frame	NN
cord-018804-wj35q88f	311	17	,	,	,
cord-018804-wj35q88f	311	18	contrasting	contrast	VBG
cord-018804-wj35q88f	311	19	with	with	IN
cord-018804-wj35q88f	311	20	the	the	DT
cord-018804-wj35q88f	311	21	conservation	conservation	NN
cord-018804-wj35q88f	311	22	of	of	IN
cord-018804-wj35q88f	311	23	this	this	DT
cord-018804-wj35q88f	311	24	region	region	NN
cord-018804-wj35q88f	311	25	in	in	IN
cord-018804-wj35q88f	311	26	natural	natural	JJ
cord-018804-wj35q88f	311	27	isolates	isolate	NNS
cord-018804-wj35q88f	311	28	[	[	-LRB-
cord-018804-wj35q88f	311	29	66	66	CD
cord-018804-wj35q88f	311	30	]	]	-RRB-
cord-018804-wj35q88f	311	31	.	.	.
cord-018804-wj35q88f	312	1	All	all	PDT
cord-018804-wj35q88f	312	2	these	these	DT
cord-018804-wj35q88f	312	3	results	result	NNS
cord-018804-wj35q88f	312	4	suggest	suggest	VBP
cord-018804-wj35q88f	312	5	that	that	IN
cord-018804-wj35q88f	312	6	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	312	7	permit	permit	VB
cord-018804-wj35q88f	312	8	the	the	DT
cord-018804-wj35q88f	312	9	isolation	isolation	NN
cord-018804-wj35q88f	312	10	of	of	IN
cord-018804-wj35q88f	312	11	genomes	genome	NNS
cord-018804-wj35q88f	312	12	that	that	WDT
cord-018804-wj35q88f	312	13	[	[	-LRB-
cord-018804-wj35q88f	312	14	72	72	CD
cord-018804-wj35q88f	312	15	]	]	-RRB-
cord-018804-wj35q88f	312	16	.	.	.
cord-018804-wj35q88f	313	1	The	the	DT
cord-018804-wj35q88f	313	2	lines	line	NNS
cord-018804-wj35q88f	313	3	below	below	IN
cord-018804-wj35q88f	313	4	the	the	DT
cord-018804-wj35q88f	313	5	genome	genome	NN
cord-018804-wj35q88f	313	6	indicate	indicate	VBP
cord-018804-wj35q88f	313	7	the	the	DT
cord-018804-wj35q88f	313	8	non	non	JJ
cord-018804-wj35q88f	313	9	-	-	JJ
cord-018804-wj35q88f	313	10	synonymous	synonymous	JJ
cord-018804-wj35q88f	313	11	(	(	-LRB-
cord-018804-wj35q88f	313	12	ns	ns	IN
cord-018804-wj35q88f	313	13	)	)	-RRB-
cord-018804-wj35q88f	313	14	and	and	CC
cord-018804-wj35q88f	313	15	synonymous	synonymous	JJ
cord-018804-wj35q88f	313	16	(	(	-LRB-
cord-018804-wj35q88f	313	17	s	s	NNS
cord-018804-wj35q88f	313	18	)	)	-RRB-
cord-018804-wj35q88f	313	19	mutations	mutation	NNS
cord-018804-wj35q88f	313	20	present	present	JJ
cord-018804-wj35q88f	313	21	in	in	IN
cord-018804-wj35q88f	313	22	the	the	DT
cord-018804-wj35q88f	313	23	virus	virus	NN
cord-018804-wj35q88f	313	24	.	.	.
cord-018804-wj35q88f	314	1	The	the	DT
cord-018804-wj35q88f	314	2	boxes	box	NNS
cord-018804-wj35q88f	314	3	indicate	indicate	VBP
cord-018804-wj35q88f	314	4	the	the	DT
cord-018804-wj35q88f	314	5	genomic	genomic	JJ
cord-018804-wj35q88f	314	6	regions	region	NNS
cord-018804-wj35q88f	314	7	where	where	WRB
cord-018804-wj35q88f	314	8	the	the	DT
cord-018804-wj35q88f	314	9	number	number	NN
cord-018804-wj35q88f	314	10	of	of	IN
cord-018804-wj35q88f	314	11	mutations	mutation	NNS
cord-018804-wj35q88f	314	12	is	be	VBZ
cord-018804-wj35q88f	314	13	significantly	significantly	RB
cord-018804-wj35q88f	314	14	higher	high	JJR
cord-018804-wj35q88f	314	15	than	than	IN
cord-018804-wj35q88f	314	16	the	the	DT
cord-018804-wj35q88f	314	17	average	average	NN
cord-018804-wj35q88f	314	18	for	for	IN
cord-018804-wj35q88f	314	19	the	the	DT
cord-018804-wj35q88f	314	20	whole	whole	JJ
cord-018804-wj35q88f	314	21	genome	genome	NN
cord-018804-wj35q88f	314	22	otherwise	otherwise	RB
cord-018804-wj35q88f	314	23	would	would	MD
cord-018804-wj35q88f	314	24	be	be	VB
cord-018804-wj35q88f	314	25	eliminated	eliminate	VBN
cord-018804-wj35q88f	314	26	under	under	IN
cord-018804-wj35q88f	314	27	the	the	DT
cord-018804-wj35q88f	314	28	action	action	NN
cord-018804-wj35q88f	314	29	of	of	IN
cord-018804-wj35q88f	314	30	positive	positive	JJ
cord-018804-wj35q88f	314	31	selection	selection	NN
cord-018804-wj35q88f	314	32	that	that	WDT
cord-018804-wj35q88f	314	33	dominates	dominate	VBZ
cord-018804-wj35q88f	314	34	virus	virus	NN
cord-018804-wj35q88f	314	35	optimization	optimization	NN
cord-018804-wj35q88f	314	36	.	.	.
cord-018804-wj35q88f	315	1	Genomic	genomic	JJ
cord-018804-wj35q88f	315	2	regions	region	NNS
cord-018804-wj35q88f	315	3	that	that	WDT
cord-018804-wj35q88f	315	4	seem	seem	VBP
cord-018804-wj35q88f	315	5	to	to	TO
cord-018804-wj35q88f	315	6	be	be	VB
cord-018804-wj35q88f	315	7	much	much	RB
cord-018804-wj35q88f	315	8	conserved	conserved	JJ
cord-018804-wj35q88f	315	9	might	may	MD
cord-018804-wj35q88f	315	10	mutate	mutate	VB
cord-018804-wj35q88f	315	11	with	with	IN
cord-018804-wj35q88f	315	12	the	the	DT
cord-018804-wj35q88f	315	13	same	same	JJ
cord-018804-wj35q88f	315	14	mutation	mutation	NN
cord-018804-wj35q88f	315	15	rate	rate	NN
cord-018804-wj35q88f	315	16	as	as	IN
cord-018804-wj35q88f	315	17	the	the	DT
cord-018804-wj35q88f	315	18	rest	rest	NN
cord-018804-wj35q88f	315	19	of	of	IN
cord-018804-wj35q88f	315	20	the	the	DT
cord-018804-wj35q88f	315	21	genome	genome	NN
cord-018804-wj35q88f	315	22	,	,	,
cord-018804-wj35q88f	315	23	although	although	IN
cord-018804-wj35q88f	315	24	subjected	subject	VBN
cord-018804-wj35q88f	315	25	to	to	IN
cord-018804-wj35q88f	315	26	stronger	strong	JJR
cord-018804-wj35q88f	315	27	constraints	constraint	NNS
cord-018804-wj35q88f	315	28	.	.	.
cord-018804-wj35q88f	316	1	Nevertheless	nevertheless	RB
cord-018804-wj35q88f	316	2	,	,	,
cord-018804-wj35q88f	316	3	the	the	DT
cord-018804-wj35q88f	316	4	evolutionary	evolutionary	JJ
cord-018804-wj35q88f	316	5	relevance	relevance	NN
cord-018804-wj35q88f	316	6	and	and	CC
cord-018804-wj35q88f	316	7	the	the	DT
cord-018804-wj35q88f	316	8	molecular	molecular	JJ
cord-018804-wj35q88f	316	9	mechanism	mechanism	NN
cord-018804-wj35q88f	316	10	by	by	IN
cord-018804-wj35q88f	316	11	which	which	WDT
cord-018804-wj35q88f	316	12	the	the	DT
cord-018804-wj35q88f	316	13	mutation	mutation	NN
cord-018804-wj35q88f	316	14	clusters	cluster	NNS
cord-018804-wj35q88f	316	15	observed	observe	VBD
cord-018804-wj35q88f	316	16	in	in	IN
cord-018804-wj35q88f	316	17	the	the	DT
cord-018804-wj35q88f	316	18	bottlenecked	bottleneck	VBN
cord-018804-wj35q88f	316	19	FMDV	FMDV	NNP
cord-018804-wj35q88f	316	20	clones	clone	NNS
cord-018804-wj35q88f	316	21	are	be	VBP
cord-018804-wj35q88f	316	22	generated	generate	VBN
cord-018804-wj35q88f	316	23	is	be	VBZ
cord-018804-wj35q88f	317	1	unknown	unknown	JJ
cord-018804-wj35q88f	317	2	and	and	CC
cord-018804-wj35q88f	317	3	further	further	JJ
cord-018804-wj35q88f	317	4	experiments	experiment	NNS
cord-018804-wj35q88f	317	5	are	be	VBP
cord-018804-wj35q88f	317	6	in	in	IN
cord-018804-wj35q88f	317	7	progress	progress	NN
cord-018804-wj35q88f	317	8	to	to	TO
cord-018804-wj35q88f	317	9	answer	answer	VB
cord-018804-wj35q88f	317	10	this	this	DT
cord-018804-wj35q88f	317	11	question	question	NN
cord-018804-wj35q88f	317	12	.	.	.
cord-018804-wj35q88f	318	1	A	a	DT
cord-018804-wj35q88f	318	2	numerical	numerical	JJ
cord-018804-wj35q88f	318	3	model	model	NN
cord-018804-wj35q88f	318	4	of	of	IN
cord-018804-wj35q88f	318	5	evolution	evolution	NN
cord-018804-wj35q88f	318	6	through	through	IN
cord-018804-wj35q88f	318	7	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	318	8	was	be	VBD
cord-018804-wj35q88f	318	9	developed	develop	VBN
cord-018804-wj35q88f	318	10	with	with	IN
cord-018804-wj35q88f	318	11	the	the	DT
cord-018804-wj35q88f	318	12	aim	aim	NN
cord-018804-wj35q88f	318	13	of	of	IN
cord-018804-wj35q88f	318	14	identifying	identify	VBG
cord-018804-wj35q88f	318	15	the	the	DT
cord-018804-wj35q88f	318	16	parameters	parameter	NNS
cord-018804-wj35q88f	318	17	that	that	WDT
cord-018804-wj35q88f	318	18	are	be	VBP
cord-018804-wj35q88f	318	19	responsible	responsible	JJ
cord-018804-wj35q88f	318	20	for	for	IN
cord-018804-wj35q88f	318	21	the	the	DT
cord-018804-wj35q88f	318	22	biphasic	biphasic	JJ
cord-018804-wj35q88f	318	23	dynamics	dynamic	NNS
cord-018804-wj35q88f	318	24	of	of	IN
cord-018804-wj35q88f	318	25	fitness	fitness	NN
cord-018804-wj35q88f	318	26	loss	loss	NN
cord-018804-wj35q88f	318	27	[	[	-LRB-
cord-018804-wj35q88f	318	28	74	74	CD
cord-018804-wj35q88f	318	29	,	,	,
cord-018804-wj35q88f	318	30	75	75	CD
cord-018804-wj35q88f	318	31	]	]	-RRB-
cord-018804-wj35q88f	318	32	.	.	.
cord-018804-wj35q88f	319	1	The	the	DT
cord-018804-wj35q88f	319	2	main	main	JJ
cord-018804-wj35q88f	319	3	features	feature	NNS
cord-018804-wj35q88f	319	4	of	of	IN
cord-018804-wj35q88f	319	5	the	the	DT
cord-018804-wj35q88f	319	6	model	model	NN
cord-018804-wj35q88f	319	7	are	be	VBP
cord-018804-wj35q88f	319	8	the	the	DT
cord-018804-wj35q88f	319	9	occurrence	occurrence	NN
cord-018804-wj35q88f	319	10	with	with	IN
cord-018804-wj35q88f	319	11	low	low	JJ
cord-018804-wj35q88f	319	12	probability	probability	NN
cord-018804-wj35q88f	319	13	of	of	IN
cord-018804-wj35q88f	319	14	advantageous	advantageous	JJ
cord-018804-wj35q88f	319	15	mutations	mutation	NNS
cord-018804-wj35q88f	319	16	and	and	CC
cord-018804-wj35q88f	319	17	the	the	DT
cord-018804-wj35q88f	319	18	presence	presence	NN
cord-018804-wj35q88f	319	19	of	of	IN
cord-018804-wj35q88f	319	20	an	an	DT
cord-018804-wj35q88f	319	21	extinction	extinction	NN
cord-018804-wj35q88f	319	22	threshold	threshold	NN
cord-018804-wj35q88f	319	23	,	,	,
cord-018804-wj35q88f	319	24	which	which	WDT
cord-018804-wj35q88f	319	25	means	mean	VBZ
cord-018804-wj35q88f	319	26	that	that	IN
cord-018804-wj35q88f	319	27	genomes	genome	NNS
cord-018804-wj35q88f	319	28	reaching	reach	VBG
cord-018804-wj35q88f	319	29	the	the	DT
cord-018804-wj35q88f	319	30	minimal	minimal	JJ
cord-018804-wj35q88f	319	31	allowed	allow	VBN
cord-018804-wj35q88f	319	32	fitness	fitness	NN
cord-018804-wj35q88f	319	33	value	value	NN
cord-018804-wj35q88f	319	34	are	be	VBP
cord-018804-wj35q88f	319	35	eliminated	eliminate	VBN
cord-018804-wj35q88f	319	36	.	.	.
cord-018804-wj35q88f	320	1	The	the	DT
cord-018804-wj35q88f	320	2	results	result	NNS
cord-018804-wj35q88f	320	3	of	of	IN
cord-018804-wj35q88f	320	4	the	the	DT
cord-018804-wj35q88f	320	5	simulations	simulation	NNS
cord-018804-wj35q88f	320	6	were	be	VBD
cord-018804-wj35q88f	320	7	very	very	RB
cord-018804-wj35q88f	320	8	similar	similar	JJ
cord-018804-wj35q88f	320	9	to	to	IN
cord-018804-wj35q88f	320	10	those	those	DT
cord-018804-wj35q88f	320	11	observed	observe	VBN
cord-018804-wj35q88f	320	12	in	in	IN
cord-018804-wj35q88f	320	13	the	the	DT
cord-018804-wj35q88f	320	14	experiments	experiment	NNS
cord-018804-wj35q88f	320	15	:	:	:
cord-018804-wj35q88f	320	16	a	a	DT
cord-018804-wj35q88f	320	17	biphasic	biphasic	JJ
cord-018804-wj35q88f	320	18	dynamics	dynamic	NNS
cord-018804-wj35q88f	320	19	of	of	IN
cord-018804-wj35q88f	320	20	fitness	fitness	NN
cord-018804-wj35q88f	320	21	decrease	decrease	NN
cord-018804-wj35q88f	320	22	and	and	CC
cord-018804-wj35q88f	320	23	large	large	JJ
cord-018804-wj35q88f	320	24	fluctuations	fluctuation	NNS
cord-018804-wj35q88f	320	25	in	in	IN
cord-018804-wj35q88f	320	26	the	the	DT
cord-018804-wj35q88f	320	27	fitness	fitness	NN
cord-018804-wj35q88f	320	28	values	value	NNS
cord-018804-wj35q88f	320	29	attained	attain	VBN
cord-018804-wj35q88f	320	30	at	at	IN
cord-018804-wj35q88f	320	31	the	the	DT
cord-018804-wj35q88f	320	32	stationary	stationary	JJ
cord-018804-wj35q88f	320	33	state	state	NN
cord-018804-wj35q88f	320	34	.	.	.
cord-018804-wj35q88f	321	1	Moreover	moreover	RB
cord-018804-wj35q88f	321	2	,	,	,
cord-018804-wj35q88f	321	3	the	the	DT
cord-018804-wj35q88f	321	4	statistical	statistical	JJ
cord-018804-wj35q88f	321	5	analysis	analysis	NN
cord-018804-wj35q88f	321	6	of	of	IN
cord-018804-wj35q88f	321	7	fitness	fitness	NN
cord-018804-wj35q88f	321	8	values	value	NNS
cord-018804-wj35q88f	321	9	reveals	reveal	VBZ
cord-018804-wj35q88f	321	10	that	that	IN
cord-018804-wj35q88f	321	11	,	,	,
cord-018804-wj35q88f	321	12	similarly	similarly	RB
cord-018804-wj35q88f	321	13	to	to	IN
cord-018804-wj35q88f	321	14	the	the	DT
cord-018804-wj35q88f	321	15	experimental	experimental	JJ
cord-018804-wj35q88f	321	16	results	result	NNS
cord-018804-wj35q88f	321	17	,	,	,
cord-018804-wj35q88f	321	18	they	-PRON-	PRP
cord-018804-wj35q88f	321	19	follow	follow	VBP
cord-018804-wj35q88f	321	20	a	a	DT
cord-018804-wj35q88f	321	21	Weibull	Weibull	NNP
cord-018804-wj35q88f	321	22	distribution	distribution	NN
cord-018804-wj35q88f	321	23	,	,	,
cord-018804-wj35q88f	321	24	strongly	strongly	RB
cord-018804-wj35q88f	321	25	supporting	support	VBG
cord-018804-wj35q88f	321	26	that	that	IN
cord-018804-wj35q88f	321	27	the	the	DT
cord-018804-wj35q88f	321	28	underlying	underlie	VBG
cord-018804-wj35q88f	321	29	dynamics	dynamic	NNS
cord-018804-wj35q88f	321	30	must	must	MD
cord-018804-wj35q88f	321	31	be	be	VB
cord-018804-wj35q88f	321	32	the	the	DT
cord-018804-wj35q88f	321	33	same	same	JJ
cord-018804-wj35q88f	321	34	in	in	IN
cord-018804-wj35q88f	321	35	both	both	CC
cord-018804-wj35q88f	321	36	the	the	DT
cord-018804-wj35q88f	321	37	simulations	simulation	NNS
cord-018804-wj35q88f	321	38	and	and	CC
cord-018804-wj35q88f	321	39	the	the	DT
cord-018804-wj35q88f	321	40	experiments	experiment	NNS
cord-018804-wj35q88f	321	41	.	.	.
cord-018804-wj35q88f	322	1	The	the	DT
cord-018804-wj35q88f	322	2	elimination	elimination	NN
cord-018804-wj35q88f	322	3	of	of	IN
cord-018804-wj35q88f	322	4	individuals	individual	NNS
cord-018804-wj35q88f	322	5	as	as	IN
cord-018804-wj35q88f	322	6	their	-PRON-	PRP$
cord-018804-wj35q88f	322	7	fitness	fitness	NN
cord-018804-wj35q88f	322	8	falls	fall	VBZ
cord-018804-wj35q88f	322	9	below	below	IN
cord-018804-wj35q88f	322	10	the	the	DT
cord-018804-wj35q88f	322	11	extinction	extinction	NN
cord-018804-wj35q88f	322	12	threshold	threshold	NN
cord-018804-wj35q88f	322	13	and	and	CC
cord-018804-wj35q88f	322	14	the	the	DT
cord-018804-wj35q88f	322	15	probability	probability	NN
cord-018804-wj35q88f	322	16	of	of	IN
cord-018804-wj35q88f	322	17	selecting	select	VBG
cord-018804-wj35q88f	322	18	for	for	IN
cord-018804-wj35q88f	322	19	the	the	DT
cord-018804-wj35q88f	322	20	subsequent	subsequent	JJ
cord-018804-wj35q88f	322	21	transfer	transfer	NN
cord-018804-wj35q88f	322	22	genomes	genome	NNS
cord-018804-wj35q88f	322	23	with	with	IN
cord-018804-wj35q88f	322	24	compensatory	compensatory	JJ
cord-018804-wj35q88f	322	25	mutations	mutation	NNS
cord-018804-wj35q88f	322	26	constitute	constitute	VBP
cord-018804-wj35q88f	322	27	two	two	CD
cord-018804-wj35q88f	322	28	factors	factor	NNS
cord-018804-wj35q88f	322	29	acting	act	VBG
cord-018804-wj35q88f	322	30	in	in	IN
cord-018804-wj35q88f	322	31	close	close	JJ
cord-018804-wj35q88f	322	32	concert	concert	NN
cord-018804-wj35q88f	322	33	to	to	TO
cord-018804-wj35q88f	322	34	avoid	avoid	VB
cord-018804-wj35q88f	322	35	extinctions	extinction	NNS
cord-018804-wj35q88f	322	36	due	due	JJ
cord-018804-wj35q88f	322	37	to	to	IN
cord-018804-wj35q88f	322	38	an	an	DT
cord-018804-wj35q88f	322	39	excessive	excessive	JJ
cord-018804-wj35q88f	322	40	accumulation	accumulation	NN
cord-018804-wj35q88f	322	41	of	of	IN
cord-018804-wj35q88f	322	42	deleterious	deleterious	JJ
cord-018804-wj35q88f	322	43	mutations	mutation	NNS
cord-018804-wj35q88f	322	44	.	.	.
cord-018804-wj35q88f	323	1	The	the	DT
cord-018804-wj35q88f	323	2	occurrence	occurrence	NN
cord-018804-wj35q88f	323	3	of	of	IN
cord-018804-wj35q88f	323	4	compensatory	compensatory	JJ
cord-018804-wj35q88f	323	5	,	,	,
cord-018804-wj35q88f	323	6	advantageous	advantageous	JJ
cord-018804-wj35q88f	323	7	mutations	mutation	NNS
cord-018804-wj35q88f	323	8	was	be	VBD
cord-018804-wj35q88f	323	9	not	not	RB
cord-018804-wj35q88f	323	10	introduced	introduce	VBN
cord-018804-wj35q88f	323	11	in	in	IN
cord-018804-wj35q88f	323	12	most	most	JJS
cord-018804-wj35q88f	323	13	models	model	NNS
cord-018804-wj35q88f	323	14	of	of	IN
cord-018804-wj35q88f	323	15	Muller	Muller	NNP
cord-018804-wj35q88f	323	16	's	's	POS
cord-018804-wj35q88f	323	17	ratchet	ratchet	NN
cord-018804-wj35q88f	323	18	that	that	WDT
cord-018804-wj35q88f	323	19	considered	consider	VBD
cord-018804-wj35q88f	323	20	that	that	IN
cord-018804-wj35q88f	323	21	back	back	JJ
cord-018804-wj35q88f	323	22	mutations	mutation	NNS
cord-018804-wj35q88f	323	23	were	be	VBD
cord-018804-wj35q88f	323	24	the	the	DT
cord-018804-wj35q88f	323	25	only	only	JJ
cord-018804-wj35q88f	323	26	mechanism	mechanism	NN
cord-018804-wj35q88f	323	27	to	to	TO
cord-018804-wj35q88f	323	28	revert	revert	VB
cord-018804-wj35q88f	323	29	the	the	DT
cord-018804-wj35q88f	323	30	negative	negative	JJ
cord-018804-wj35q88f	323	31	effect	effect	NN
cord-018804-wj35q88f	323	32	of	of	IN
cord-018804-wj35q88f	323	33	deleterious	deleterious	JJ
cord-018804-wj35q88f	323	34	mutations	mutation	NNS
cord-018804-wj35q88f	323	35	[	[	-LRB-
cord-018804-wj35q88f	323	36	76	76	CD
cord-018804-wj35q88f	323	37	,	,	,
cord-018804-wj35q88f	323	38	77	77	CD
cord-018804-wj35q88f	323	39	]	]	-RRB-
cord-018804-wj35q88f	323	40	.	.	.
cord-018804-wj35q88f	324	1	However	however	RB
cord-018804-wj35q88f	324	2	,	,	,
cord-018804-wj35q88f	324	3	compensatory	compensatory	JJ
cord-018804-wj35q88f	324	4	mutations	mutation	NNS
cord-018804-wj35q88f	324	5	are	be	VBP
cord-018804-wj35q88f	324	6	much	much	RB
cord-018804-wj35q88f	324	7	more	more	RBR
cord-018804-wj35q88f	324	8	frequent	frequent	JJ
cord-018804-wj35q88f	324	9	than	than	IN
cord-018804-wj35q88f	324	10	reversions	reversion	NNS
cord-018804-wj35q88f	324	11	as	as	IN
cord-018804-wj35q88f	324	12	a	a	DT
cord-018804-wj35q88f	324	13	mechanism	mechanism	NN
cord-018804-wj35q88f	324	14	to	to	TO
cord-018804-wj35q88f	324	15	increase	increase	VB
cord-018804-wj35q88f	324	16	fitness	fitness	NN
cord-018804-wj35q88f	324	17	,	,	,
cord-018804-wj35q88f	324	18	as	as	IN
cord-018804-wj35q88f	324	19	it	-PRON-	PRP
cord-018804-wj35q88f	324	20	has	have	VBZ
cord-018804-wj35q88f	324	21	been	be	VBN
cord-018804-wj35q88f	324	22	demonstrated	demonstrate	VBN
cord-018804-wj35q88f	324	23	in	in	IN
cord-018804-wj35q88f	324	24	several	several	JJ
cord-018804-wj35q88f	324	25	theoretical	theoretical	JJ
cord-018804-wj35q88f	324	26	and	and	CC
cord-018804-wj35q88f	324	27	experimental	experimental	JJ
cord-018804-wj35q88f	324	28	studies	study	NNS
cord-018804-wj35q88f	324	29	[	[	-LRB-
cord-018804-wj35q88f	324	30	78	78	CD
cord-018804-wj35q88f	324	31	,	,	,
cord-018804-wj35q88f	324	32	79	79	CD
cord-018804-wj35q88f	324	33	]	]	-RRB-
cord-018804-wj35q88f	324	34	.	.	.
cord-018804-wj35q88f	325	1	Accordingly	accordingly	RB
cord-018804-wj35q88f	325	2	,	,	,
cord-018804-wj35q88f	325	3	during	during	IN
cord-018804-wj35q88f	325	4	the	the	DT
cord-018804-wj35q88f	325	5	process	process	NN
cord-018804-wj35q88f	325	6	of	of	IN
cord-018804-wj35q88f	325	7	fitness	fitness	NN
cord-018804-wj35q88f	325	8	recovery	recovery	NN
cord-018804-wj35q88f	325	9	of	of	IN
cord-018804-wj35q88f	325	10	FMDV	FMDV	NNP
cord-018804-wj35q88f	325	11	and	and	CC
cord-018804-wj35q88f	325	12	VSV	VSV	NNP
cord-018804-wj35q88f	325	13	bottlenecked	bottleneck	VBD
cord-018804-wj35q88f	325	14	clones	clone	NNS
cord-018804-wj35q88f	325	15	upon	upon	IN
cord-018804-wj35q88f	325	16	large	large	JJ
cord-018804-wj35q88f	325	17	population	population	NN
cord-018804-wj35q88f	325	18	passages	passage	NNS
cord-018804-wj35q88f	325	19	,	,	,
cord-018804-wj35q88f	325	20	both	both	CC
cord-018804-wj35q88f	325	21	reversions	reversion	NNS
cord-018804-wj35q88f	325	22	and	and	CC
cord-018804-wj35q88f	325	23	compensatory	compensatory	JJ
cord-018804-wj35q88f	325	24	mutations	mutation	NNS
cord-018804-wj35q88f	325	25	were	be	VBD
cord-018804-wj35q88f	325	26	found	find	VBN
cord-018804-wj35q88f	325	27	to	to	TO
cord-018804-wj35q88f	325	28	be	be	VB
cord-018804-wj35q88f	325	29	responsible	responsible	JJ
cord-018804-wj35q88f	325	30	for	for	IN
cord-018804-wj35q88f	325	31	the	the	DT
cord-018804-wj35q88f	325	32	observed	observed	JJ
cord-018804-wj35q88f	325	33	fitness	fitness	NN
cord-018804-wj35q88f	325	34	increases	increase	NNS
cord-018804-wj35q88f	325	35	[	[	-LRB-
cord-018804-wj35q88f	325	36	64	64	CD
cord-018804-wj35q88f	325	37	,	,	,
cord-018804-wj35q88f	325	38	66	66	CD
cord-018804-wj35q88f	325	39	,	,	,
cord-018804-wj35q88f	325	40	71	71	CD
cord-018804-wj35q88f	325	41	]	]	-RRB-
cord-018804-wj35q88f	325	42	.	.	.
cord-018804-wj35q88f	326	1	None	none	NN
cord-018804-wj35q88f	326	2	of	of	IN
cord-018804-wj35q88f	326	3	the	the	DT
cord-018804-wj35q88f	326	4	recovered	recover	VBN
cord-018804-wj35q88f	326	5	strains	strain	NNS
cord-018804-wj35q88f	326	6	reverted	revert	VBN
cord-018804-wj35q88f	326	7	to	to	IN
cord-018804-wj35q88f	326	8	a	a	DT
cord-018804-wj35q88f	326	9	wild	wild	JJ
cord-018804-wj35q88f	326	10	type	type	NN
cord-018804-wj35q88f	326	11	sequence	sequence	NN
cord-018804-wj35q88f	326	12	,	,	,
cord-018804-wj35q88f	326	13	confirming	confirm	VBG
cord-018804-wj35q88f	326	14	that	that	IN
cord-018804-wj35q88f	326	15	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	326	16	move	move	VBP
cord-018804-wj35q88f	326	17	the	the	DT
cord-018804-wj35q88f	326	18	quasi	quasi	JJ
cord-018804-wj35q88f	326	19	-	-	NN
cord-018804-wj35q88f	326	20	species	specie	NNS
cord-018804-wj35q88f	326	21	through	through	IN
cord-018804-wj35q88f	326	22	the	the	DT
cord-018804-wj35q88f	326	23	fitness	fitness	NN
cord-018804-wj35q88f	326	24	landscape	landscape	NN
cord-018804-wj35q88f	326	25	towards	towards	IN
cord-018804-wj35q88f	326	26	regions	region	NNS
cord-018804-wj35q88f	326	27	where	where	WRB
cord-018804-wj35q88f	326	28	the	the	DT
cord-018804-wj35q88f	326	29	adaptive	adaptive	JJ
cord-018804-wj35q88f	326	30	value	value	NN
cord-018804-wj35q88f	326	31	of	of	IN
cord-018804-wj35q88f	326	32	mutations	mutation	NNS
cord-018804-wj35q88f	326	33	can	can	MD
cord-018804-wj35q88f	326	34	be	be	VB
cord-018804-wj35q88f	326	35	drastically	drastically	RB
cord-018804-wj35q88f	326	36	altered	alter	VBN
cord-018804-wj35q88f	326	37	.	.	.
cord-018804-wj35q88f	327	1	The	the	DT
cord-018804-wj35q88f	327	2	results	result	NNS
cord-018804-wj35q88f	327	3	of	of	IN
cord-018804-wj35q88f	327	4	all	all	PDT
cord-018804-wj35q88f	327	5	these	these	DT
cord-018804-wj35q88f	327	6	studies	study	NNS
cord-018804-wj35q88f	327	7	show	show	VBP
cord-018804-wj35q88f	327	8	that	that	IN
cord-018804-wj35q88f	327	9	there	there	EX
cord-018804-wj35q88f	327	10	are	be	VBP
cord-018804-wj35q88f	327	11	different	different	JJ
cord-018804-wj35q88f	327	12	mechanisms	mechanism	NNS
cord-018804-wj35q88f	327	13	able	able	JJ
cord-018804-wj35q88f	327	14	to	to	TO
cord-018804-wj35q88f	327	15	modulate	modulate	VB
cord-018804-wj35q88f	327	16	the	the	DT
cord-018804-wj35q88f	327	17	adaptive	adaptive	JJ
cord-018804-wj35q88f	327	18	value	value	NN
cord-018804-wj35q88f	327	19	of	of	IN
cord-018804-wj35q88f	327	20	mutations	mutation	NNS
cord-018804-wj35q88f	327	21	.	.	.
cord-018804-wj35q88f	328	1	When	when	WRB
cord-018804-wj35q88f	328	2	the	the	DT
cord-018804-wj35q88f	328	3	environment	environment	NN
cord-018804-wj35q88f	328	4	is	be	VBZ
cord-018804-wj35q88f	328	5	altered	alter	VBN
cord-018804-wj35q88f	328	6	,	,	,
cord-018804-wj35q88f	328	7	a	a	DT
cord-018804-wj35q88f	328	8	new	new	JJ
cord-018804-wj35q88f	328	9	fitness	fitness	NN
cord-018804-wj35q88f	328	10	landscape	landscape	NN
cord-018804-wj35q88f	328	11	appears	appear	VBZ
cord-018804-wj35q88f	328	12	where	where	WRB
cord-018804-wj35q88f	328	13	the	the	DT
cord-018804-wj35q88f	328	14	effect	effect	NN
cord-018804-wj35q88f	328	15	of	of	IN
cord-018804-wj35q88f	328	16	particular	particular	JJ
cord-018804-wj35q88f	328	17	mutations	mutation	NNS
cord-018804-wj35q88f	328	18	varies	vary	VBZ
cord-018804-wj35q88f	328	19	.	.	.
cord-018804-wj35q88f	329	1	In	in	IN
cord-018804-wj35q88f	329	2	a	a	DT
cord-018804-wj35q88f	329	3	similar	similar	JJ
cord-018804-wj35q88f	329	4	way	way	NN
cord-018804-wj35q88f	329	5	,	,	,
cord-018804-wj35q88f	329	6	even	even	RB
cord-018804-wj35q88f	329	7	if	if	IN
cord-018804-wj35q88f	329	8	the	the	DT
cord-018804-wj35q88f	329	9	fitness	fitness	NN
cord-018804-wj35q88f	329	10	landscape	landscape	NN
cord-018804-wj35q88f	329	11	is	be	VBZ
cord-018804-wj35q88f	329	12	not	not	RB
cord-018804-wj35q88f	329	13	modified	modify	VBN
cord-018804-wj35q88f	329	14	,	,	,
cord-018804-wj35q88f	329	15	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	329	16	constitute	constitute	VBP
cord-018804-wj35q88f	329	17	an	an	DT
cord-018804-wj35q88f	329	18	effective	effective	JJ
cord-018804-wj35q88f	329	19	way	way	NN
cord-018804-wj35q88f	329	20	to	to	TO
cord-018804-wj35q88f	329	21	explore	explore	VB
cord-018804-wj35q88f	329	22	new	new	JJ
cord-018804-wj35q88f	329	23	regions	region	NNS
cord-018804-wj35q88f	329	24	,	,	,
cord-018804-wj35q88f	329	25	where	where	WRB
cord-018804-wj35q88f	329	26	the	the	DT
cord-018804-wj35q88f	329	27	selective	selective	JJ
cord-018804-wj35q88f	329	28	value	value	NN
cord-018804-wj35q88f	329	29	of	of	IN
cord-018804-wj35q88f	329	30	mutations	mutation	NNS
cord-018804-wj35q88f	329	31	can	can	MD
cord-018804-wj35q88f	329	32	differ	differ	VB
cord-018804-wj35q88f	329	33	from	from	IN
cord-018804-wj35q88f	329	34	that	that	DT
cord-018804-wj35q88f	329	35	present	present	JJ
cord-018804-wj35q88f	329	36	in	in	IN
cord-018804-wj35q88f	329	37	the	the	DT
cord-018804-wj35q88f	329	38	initial	initial	JJ
cord-018804-wj35q88f	329	39	quasi	quasi	JJ
cord-018804-wj35q88f	329	40	-	-	NNS
cord-018804-wj35q88f	329	41	species	specie	NNS
cord-018804-wj35q88f	329	42	.	.	.
cord-018804-wj35q88f	330	1	This	this	DT
cord-018804-wj35q88f	330	2	means	mean	VBZ
cord-018804-wj35q88f	330	3	that	that	IN
cord-018804-wj35q88f	330	4	the	the	DT
cord-018804-wj35q88f	330	5	effect	effect	NN
cord-018804-wj35q88f	330	6	of	of	IN
cord-018804-wj35q88f	330	7	mutations	mutation	NNS
cord-018804-wj35q88f	330	8	can	can	MD
cord-018804-wj35q88f	330	9	vary	vary	VB
cord-018804-wj35q88f	330	10	depending	depend	VBG
cord-018804-wj35q88f	330	11	on	on	IN
cord-018804-wj35q88f	330	12	the	the	DT
cord-018804-wj35q88f	330	13	mutations	mutation	NNS
cord-018804-wj35q88f	330	14	previously	previously	RB
cord-018804-wj35q88f	330	15	accumulated	accumulate	VBN
cord-018804-wj35q88f	330	16	in	in	IN
cord-018804-wj35q88f	330	17	the	the	DT
cord-018804-wj35q88f	330	18	genome	genome	NN
cord-018804-wj35q88f	330	19	,	,	,
cord-018804-wj35q88f	330	20	a	a	DT
cord-018804-wj35q88f	330	21	fact	fact	NN
cord-018804-wj35q88f	330	22	that	that	IN
cord-018804-wj35q88f	330	23	points	point	VBZ
cord-018804-wj35q88f	330	24	to	to	IN
cord-018804-wj35q88f	330	25	epistatic	epistatic	JJ
cord-018804-wj35q88f	330	26	interactions	interaction	NNS
cord-018804-wj35q88f	330	27	.	.	.
cord-018804-wj35q88f	331	1	Sanjuán	Sanjuán	NNP
cord-018804-wj35q88f	331	2	et	et	NNP
cord-018804-wj35q88f	331	3	al	al	NNP
cord-018804-wj35q88f	331	4	.	.	NNP
cord-018804-wj35q88f	331	5	have	have	VBP
cord-018804-wj35q88f	331	6	studied	study	VBN
cord-018804-wj35q88f	331	7	the	the	DT
cord-018804-wj35q88f	331	8	effect	effect	NN
cord-018804-wj35q88f	331	9	of	of	IN
cord-018804-wj35q88f	331	10	pair	pair	NN
cord-018804-wj35q88f	331	11	of	of	IN
cord-018804-wj35q88f	331	12	mutations	mutation	NNS
cord-018804-wj35q88f	331	13	in	in	IN
cord-018804-wj35q88f	331	14	the	the	DT
cord-018804-wj35q88f	331	15	VSV	VSV	NNP
cord-018804-wj35q88f	331	16	genome	genome	NN
cord-018804-wj35q88f	331	17	,	,	,
cord-018804-wj35q88f	331	18	compared	compare	VBN
cord-018804-wj35q88f	331	19	to	to	IN
cord-018804-wj35q88f	331	20	their	-PRON-	PRP$
cord-018804-wj35q88f	331	21	effects	effect	NNS
cord-018804-wj35q88f	331	22	as	as	IN
cord-018804-wj35q88f	331	23	single	single	JJ
cord-018804-wj35q88f	331	24	mutations	mutation	NNS
cord-018804-wj35q88f	331	25	[	[	-LRB-
cord-018804-wj35q88f	331	26	80	80	CD
cord-018804-wj35q88f	331	27	]	]	-RRB-
cord-018804-wj35q88f	331	28	.	.	.
cord-018804-wj35q88f	332	1	They	-PRON-	PRP
cord-018804-wj35q88f	332	2	found	find	VBD
cord-018804-wj35q88f	332	3	mainly	mainly	RB
cord-018804-wj35q88f	332	4	antagonistic	antagonistic	JJ
cord-018804-wj35q88f	332	5	interactions	interaction	NNS
cord-018804-wj35q88f	332	6	between	between	IN
cord-018804-wj35q88f	332	7	deleterious	deleterious	JJ
cord-018804-wj35q88f	332	8	mutations	mutation	NNS
cord-018804-wj35q88f	332	9	(	(	-LRB-
cord-018804-wj35q88f	332	10	the	the	DT
cord-018804-wj35q88f	332	11	effect	effect	NN
cord-018804-wj35q88f	332	12	of	of	IN
cord-018804-wj35q88f	332	13	both	both	DT
cord-018804-wj35q88f	332	14	mutations	mutation	NNS
cord-018804-wj35q88f	332	15	appearing	appear	VBG
cord-018804-wj35q88f	332	16	together	together	RB
cord-018804-wj35q88f	332	17	is	be	VBZ
cord-018804-wj35q88f	332	18	smaller	small	JJR
cord-018804-wj35q88f	332	19	than	than	IN
cord-018804-wj35q88f	332	20	the	the	DT
cord-018804-wj35q88f	332	21	sum	sum	NN
cord-018804-wj35q88f	332	22	of	of	IN
cord-018804-wj35q88f	332	23	the	the	DT
cord-018804-wj35q88f	332	24	separate	separate	JJ
cord-018804-wj35q88f	332	25	effect	effect	NN
cord-018804-wj35q88f	332	26	of	of	IN
cord-018804-wj35q88f	332	27	each	each	DT
cord-018804-wj35q88f	332	28	mutation	mutation	NN
cord-018804-wj35q88f	332	29	)	)	-RRB-
cord-018804-wj35q88f	332	30	.	.	.
cord-018804-wj35q88f	333	1	This	this	DT
cord-018804-wj35q88f	333	2	finding	finding	NN
cord-018804-wj35q88f	333	3	can	can	MD
cord-018804-wj35q88f	333	4	partially	partially	RB
cord-018804-wj35q88f	333	5	explain	explain	VB
cord-018804-wj35q88f	333	6	the	the	DT
cord-018804-wj35q88f	333	7	non	non	JJ
cord-018804-wj35q88f	333	8	-	-	JJ
cord-018804-wj35q88f	333	9	linear	linear	JJ
cord-018804-wj35q88f	333	10	dynamics	dynamic	NNS
cord-018804-wj35q88f	333	11	of	of	IN
cord-018804-wj35q88f	333	12	fitness	fitness	NN
cord-018804-wj35q88f	333	13	loss	loss	NN
cord-018804-wj35q88f	333	14	observed	observe	VBN
cord-018804-wj35q88f	333	15	in	in	IN
cord-018804-wj35q88f	333	16	the	the	DT
cord-018804-wj35q88f	333	17	FMDV	FMDV	NNP
cord-018804-wj35q88f	333	18	clones	clone	NNS
cord-018804-wj35q88f	333	19	.	.	.
cord-018804-wj35q88f	334	1	Some	some	DT
cord-018804-wj35q88f	334	2	theoretical	theoretical	JJ
cord-018804-wj35q88f	334	3	studies	study	NNS
cord-018804-wj35q88f	334	4	also	also	RB
cord-018804-wj35q88f	334	5	show	show	VBP
cord-018804-wj35q88f	334	6	that	that	IN
cord-018804-wj35q88f	334	7	antagonistic	antagonistic	JJ
cord-018804-wj35q88f	334	8	epistasis	epistasis	NN
cord-018804-wj35q88f	334	9	can	can	MD
cord-018804-wj35q88f	334	10	reduce	reduce	VB
cord-018804-wj35q88f	334	11	the	the	DT
cord-018804-wj35q88f	334	12	speed	speed	NN
cord-018804-wj35q88f	334	13	of	of	IN
cord-018804-wj35q88f	334	14	the	the	DT
cord-018804-wj35q88f	334	15	ratchet	ratchet	NN
cord-018804-wj35q88f	334	16	.	.	.
cord-018804-wj35q88f	335	1	A	a	DT
cord-018804-wj35q88f	335	2	relevant	relevant	JJ
cord-018804-wj35q88f	335	3	question	question	NN
cord-018804-wj35q88f	335	4	concerns	concern	VBZ
cord-018804-wj35q88f	335	5	the	the	DT
cord-018804-wj35q88f	335	6	effect	effect	NN
cord-018804-wj35q88f	335	7	that	that	IN
cord-018804-wj35q88f	335	8	the	the	DT
cord-018804-wj35q88f	335	9	high	high	JJ
cord-018804-wj35q88f	335	10	mutational	mutational	JJ
cord-018804-wj35q88f	335	11	load	load	NN
cord-018804-wj35q88f	335	12	of	of	IN
cord-018804-wj35q88f	335	13	viral	viral	JJ
cord-018804-wj35q88f	335	14	populations	population	NNS
cord-018804-wj35q88f	335	15	with	with	IN
cord-018804-wj35q88f	335	16	a	a	DT
cord-018804-wj35q88f	335	17	long	long	JJ
cord-018804-wj35q88f	335	18	history	history	NN
cord-018804-wj35q88f	335	19	of	of	IN
cord-018804-wj35q88f	335	20	bottlenecks	bottleneck	NNS
cord-018804-wj35q88f	335	21	has	have	VBZ
cord-018804-wj35q88f	335	22	on	on	IN
cord-018804-wj35q88f	335	23	their	-PRON-	PRP$
cord-018804-wj35q88f	335	24	adaptability	adaptability	NN
cord-018804-wj35q88f	335	25	.	.	.
cord-018804-wj35q88f	336	1	The	the	DT
cord-018804-wj35q88f	336	2	studies	study	NNS
cord-018804-wj35q88f	336	3	of	of	IN
cord-018804-wj35q88f	336	4	Novella	Novella	NNP
cord-018804-wj35q88f	336	5	[	[	-LRB-
cord-018804-wj35q88f	336	6	81	81	CD
cord-018804-wj35q88f	336	7	]	]	-RRB-
cord-018804-wj35q88f	336	8	have	have	VBP
cord-018804-wj35q88f	336	9	shown	show	VBN
cord-018804-wj35q88f	336	10	that	that	IN
cord-018804-wj35q88f	336	11	bottlenecked	bottleneck	VBN
cord-018804-wj35q88f	336	12	viruses	virus	NNS
cord-018804-wj35q88f	336	13	,	,	,
cord-018804-wj35q88f	336	14	even	even	RB
cord-018804-wj35q88f	336	15	if	if	IN
cord-018804-wj35q88f	336	16	they	-PRON-	PRP
cord-018804-wj35q88f	336	17	have	have	VBP
cord-018804-wj35q88f	336	18	recovered	recover	VBN
cord-018804-wj35q88f	336	19	fitness	fitness	NN
cord-018804-wj35q88f	336	20	through	through	IN
cord-018804-wj35q88f	336	21	massive	massive	JJ
cord-018804-wj35q88f	336	22	passages	passage	NNS
cord-018804-wj35q88f	336	23	,	,	,
cord-018804-wj35q88f	336	24	always	always	RB
cord-018804-wj35q88f	336	25	loss	loss	NN
cord-018804-wj35q88f	336	26	in	in	IN
cord-018804-wj35q88f	336	27	competition	competition	NN
cord-018804-wj35q88f	336	28	experiments	experiment	NNS
cord-018804-wj35q88f	336	29	with	with	IN
cord-018804-wj35q88f	336	30	the	the	DT
cord-018804-wj35q88f	336	31	wild	wild	JJ
cord-018804-wj35q88f	336	32	type	type	NN
cord-018804-wj35q88f	336	33	,	,	,
cord-018804-wj35q88f	336	34	meaning	mean	VBG
cord-018804-wj35q88f	336	35	that	that	IN
cord-018804-wj35q88f	336	36	they	-PRON-	PRP
cord-018804-wj35q88f	336	37	have	have	VBP
cord-018804-wj35q88f	336	38	lower	low	JJR
cord-018804-wj35q88f	336	39	adaptability	adaptability	NN
cord-018804-wj35q88f	336	40	.	.	.
cord-018804-wj35q88f	337	1	It	-PRON-	PRP
cord-018804-wj35q88f	337	2	would	would	MD
cord-018804-wj35q88f	337	3	be	be	VB
cord-018804-wj35q88f	337	4	quite	quite	RB
cord-018804-wj35q88f	337	5	interesting	interesting	JJ
cord-018804-wj35q88f	337	6	to	to	TO
cord-018804-wj35q88f	337	7	investigate	investigate	VB
cord-018804-wj35q88f	337	8	if	if	IN
cord-018804-wj35q88f	337	9	the	the	DT
cord-018804-wj35q88f	337	10	high	high	JJ
cord-018804-wj35q88f	337	11	number	number	NN
cord-018804-wj35q88f	337	12	of	of	IN
cord-018804-wj35q88f	337	13	mutations	mutation	NNS
cord-018804-wj35q88f	337	14	accumulated	accumulate	VBN
cord-018804-wj35q88f	337	15	in	in	IN
cord-018804-wj35q88f	337	16	bottlenecked	bottleneck	VBN
cord-018804-wj35q88f	337	17	viruses	virus	NNS
cord-018804-wj35q88f	337	18	also	also	RB
cord-018804-wj35q88f	337	19	has	have	VBZ
cord-018804-wj35q88f	337	20	negative	negative	JJ
cord-018804-wj35q88f	337	21	consequences	consequence	NNS
cord-018804-wj35q88f	337	22	for	for	IN
cord-018804-wj35q88f	337	23	adaptation	adaptation	NN
cord-018804-wj35q88f	337	24	to	to	IN
cord-018804-wj35q88f	337	25	a	a	DT
cord-018804-wj35q88f	337	26	new	new	JJ
cord-018804-wj35q88f	337	27	environment	environment	NN
cord-018804-wj35q88f	337	28	with	with	IN
cord-018804-wj35q88f	337	29	a	a	DT
cord-018804-wj35q88f	337	30	different	different	JJ
cord-018804-wj35q88f	337	31	fitness	fitness	NN
cord-018804-wj35q88f	337	32	landscape	landscape	NN
cord-018804-wj35q88f	337	33	.	.	.
cord-018804-wj35q88f	338	1	These	these	DT
cord-018804-wj35q88f	338	2	studies	study	NNS
cord-018804-wj35q88f	338	3	can	can	MD
cord-018804-wj35q88f	338	4	be	be	VB
cord-018804-wj35q88f	338	5	carried	carry	VBN
cord-018804-wj35q88f	338	6	out	out	RP
cord-018804-wj35q88f	338	7	with	with	IN
cord-018804-wj35q88f	338	8	viruses	virus	NNS
cord-018804-wj35q88f	338	9	carrying	carry	VBG
cord-018804-wj35q88f	338	10	different	different	JJ
cord-018804-wj35q88f	338	11	combinations	combination	NNS
cord-018804-wj35q88f	338	12	of	of	IN
cord-018804-wj35q88f	338	13	mutations	mutation	NNS
cord-018804-wj35q88f	338	14	and	and	CC
cord-018804-wj35q88f	338	15	having	have	VBG
cord-018804-wj35q88f	338	16	the	the	DT
cord-018804-wj35q88f	338	17	same	same	JJ
cord-018804-wj35q88f	338	18	fitness	fitness	NN
cord-018804-wj35q88f	338	19	value	value	NN
cord-018804-wj35q88f	338	20	,	,	,
cord-018804-wj35q88f	338	21	as	as	IN
cord-018804-wj35q88f	338	22	those	those	DT
cord-018804-wj35q88f	338	23	obtained	obtain	VBN
cord-018804-wj35q88f	338	24	at	at	IN
cord-018804-wj35q88f	338	25	different	different	JJ
cord-018804-wj35q88f	338	26	transfer	transfer	NN
cord-018804-wj35q88f	338	27	number	number	NN
cord-018804-wj35q88f	338	28	in	in	IN
cord-018804-wj35q88f	338	29	the	the	DT
cord-018804-wj35q88f	338	30	stationary	stationary	JJ
cord-018804-wj35q88f	338	31	state	state	NN
cord-018804-wj35q88f	338	32	attained	attain	VBN
cord-018804-wj35q88f	338	33	by	by	IN
cord-018804-wj35q88f	338	34	FMDV	FMDV	NNP
cord-018804-wj35q88f	338	35	bottlenecked	bottleneck	VBN
cord-018804-wj35q88f	338	36	clones	clone	NNS
cord-018804-wj35q88f	338	37	.	.	.
cord-018804-wj35q88f	339	1	The	the	DT
cord-018804-wj35q88f	339	2	results	result	NNS
cord-018804-wj35q88f	339	3	of	of	IN
cord-018804-wj35q88f	339	4	experiments	experiment	NNS
cord-018804-wj35q88f	339	5	of	of	IN
cord-018804-wj35q88f	339	6	this	this	DT
cord-018804-wj35q88f	339	7	type	type	NN
cord-018804-wj35q88f	339	8	would	would	MD
cord-018804-wj35q88f	339	9	allow	allow	VB
cord-018804-wj35q88f	339	10	to	to	TO
cord-018804-wj35q88f	339	11	get	get	VB
cord-018804-wj35q88f	339	12	more	more	JJR
cord-018804-wj35q88f	339	13	insight	insight	NN
cord-018804-wj35q88f	339	14	in	in	IN
cord-018804-wj35q88f	339	15	the	the	DT
cord-018804-wj35q88f	339	16	alternative	alternative	JJ
cord-018804-wj35q88f	339	17	adaptive	adaptive	JJ
cord-018804-wj35q88f	339	18	solutions	solution	NNS
cord-018804-wj35q88f	339	19	that	that	WDT
cord-018804-wj35q88f	339	20	can	can	MD
cord-018804-wj35q88f	339	21	be	be	VB
cord-018804-wj35q88f	339	22	explored	explore	VBN
cord-018804-wj35q88f	339	23	by	by	IN
cord-018804-wj35q88f	339	24	RNA	RNA	NNP
cord-018804-wj35q88f	339	25	virus	virus	NN
cord-018804-wj35q88f	339	26	populations	population	NNS
cord-018804-wj35q88f	339	27	differing	differ	VBG
cord-018804-wj35q88f	339	28	in	in	IN
cord-018804-wj35q88f	339	29	the	the	DT
cord-018804-wj35q88f	339	30	consensus	consensus	NN
cord-018804-wj35q88f	339	31	sequence	sequence	NN
cord-018804-wj35q88f	339	32	.	.	.
cord-018804-wj35q88f	340	1	Most	Most	JJS
cord-018804-wj35q88f	340	2	of	of	IN
cord-018804-wj35q88f	340	3	the	the	DT
cord-018804-wj35q88f	340	4	viruses	virus	NNS
cord-018804-wj35q88f	340	5	that	that	WDT
cord-018804-wj35q88f	340	6	are	be	VBP
cord-018804-wj35q88f	340	7	important	important	JJ
cord-018804-wj35q88f	340	8	human	human	JJ
cord-018804-wj35q88f	340	9	pathogens	pathogen	NNS
cord-018804-wj35q88f	340	10	have	have	VBP
cord-018804-wj35q88f	340	11	RNA	RNA	NNP
cord-018804-wj35q88f	340	12	as	as	IN
cord-018804-wj35q88f	340	13	genetic	genetic	JJ
cord-018804-wj35q88f	340	14	material	material	NN
cord-018804-wj35q88f	340	15	.	.	.
cord-018804-wj35q88f	341	1	All	all	DT
cord-018804-wj35q88f	341	2	of	of	IN
cord-018804-wj35q88f	341	3	them	-PRON-	PRP
cord-018804-wj35q88f	341	4	share	share	VBP
cord-018804-wj35q88f	341	5	high	high	JJ
cord-018804-wj35q88f	341	6	mutability	mutability	NN
cord-018804-wj35q88f	341	7	and	and	CC
cord-018804-wj35q88f	341	8	a	a	DT
cord-018804-wj35q88f	341	9	great	great	JJ
cord-018804-wj35q88f	341	10	potential	potential	NN
cord-018804-wj35q88f	341	11	for	for	IN
cord-018804-wj35q88f	341	12	adaptation	adaptation	NN
cord-018804-wj35q88f	341	13	that	that	WDT
cord-018804-wj35q88f	341	14	makes	make	VBZ
cord-018804-wj35q88f	341	15	their	-PRON-	PRP$
cord-018804-wj35q88f	341	16	eradication	eradication	NN
cord-018804-wj35q88f	341	17	enormously	enormously	RB
cord-018804-wj35q88f	341	18	difficult	difficult	JJ
cord-018804-wj35q88f	341	19	.	.	.
cord-018804-wj35q88f	342	1	The	the	DT
cord-018804-wj35q88f	342	2	isolation	isolation	NN
cord-018804-wj35q88f	342	3	of	of	IN
cord-018804-wj35q88f	342	4	drug	drug	NN
cord-018804-wj35q88f	342	5	-	-	HYPH
cord-018804-wj35q88f	342	6	resistant	resistant	JJ
cord-018804-wj35q88f	342	7	mutants	mutant	NNS
cord-018804-wj35q88f	342	8	,	,	,
cord-018804-wj35q88f	342	9	the	the	DT
cord-018804-wj35q88f	342	10	emergence	emergence	NN
cord-018804-wj35q88f	342	11	of	of	IN
cord-018804-wj35q88f	342	12	new	new	JJ
cord-018804-wj35q88f	342	13	diseases	disease	NNS
cord-018804-wj35q88f	342	14	in	in	IN
cord-018804-wj35q88f	342	15	humans	human	NNS
cord-018804-wj35q88f	342	16	caused	cause	VBN
cord-018804-wj35q88f	342	17	by	by	IN
cord-018804-wj35q88f	342	18	viruses	virus	NNS
cord-018804-wj35q88f	342	19	that	that	WDT
cord-018804-wj35q88f	342	20	usually	usually	RB
cord-018804-wj35q88f	342	21	are	be	VBP
cord-018804-wj35q88f	342	22	maintained	maintain	VBN
cord-018804-wj35q88f	342	23	in	in	IN
cord-018804-wj35q88f	342	24	animal	animal	NN
cord-018804-wj35q88f	342	25	reservoirs	reservoir	NNS
cord-018804-wj35q88f	342	26	or	or	CC
cord-018804-wj35q88f	342	27	the	the	DT
cord-018804-wj35q88f	342	28	appearance	appearance	NN
cord-018804-wj35q88f	342	29	of	of	IN
cord-018804-wj35q88f	342	30	viral	viral	JJ
cord-018804-wj35q88f	342	31	variants	variant	NNS
cord-018804-wj35q88f	342	32	able	able	JJ
cord-018804-wj35q88f	342	33	to	to	TO
cord-018804-wj35q88f	342	34	resist	resist	VB
cord-018804-wj35q88f	342	35	the	the	DT
cord-018804-wj35q88f	342	36	action	action	NN
cord-018804-wj35q88f	342	37	of	of	IN
cord-018804-wj35q88f	342	38	the	the	DT
cord-018804-wj35q88f	342	39	immune	immune	JJ
cord-018804-wj35q88f	342	40	system	system	NN
cord-018804-wj35q88f	342	41	of	of	IN
cord-018804-wj35q88f	342	42	the	the	DT
cord-018804-wj35q88f	342	43	host	host	NN
cord-018804-wj35q88f	342	44	constitute	constitute	VBP
cord-018804-wj35q88f	342	45	important	important	JJ
cord-018804-wj35q88f	342	46	challenges	challenge	NNS
cord-018804-wj35q88f	342	47	for	for	IN
cord-018804-wj35q88f	342	48	research	research	NN
cord-018804-wj35q88f	342	49	in	in	IN
cord-018804-wj35q88f	342	50	this	this	DT
cord-018804-wj35q88f	342	51	century	century	NN
cord-018804-wj35q88f	342	52	.	.	.
cord-018804-wj35q88f	343	1	One	one	CD
cord-018804-wj35q88f	343	2	of	of	IN
cord-018804-wj35q88f	343	3	the	the	DT
cord-018804-wj35q88f	343	4	most	most	RBS
cord-018804-wj35q88f	343	5	promising	promising	JJ
cord-018804-wj35q88f	343	6	strategies	strategy	NNS
cord-018804-wj35q88f	343	7	for	for	IN
cord-018804-wj35q88f	343	8	the	the	DT
cord-018804-wj35q88f	343	9	control	control	NN
cord-018804-wj35q88f	343	10	of	of	IN
cord-018804-wj35q88f	343	11	viral	viral	JJ
cord-018804-wj35q88f	343	12	diseases	disease	NNS
cord-018804-wj35q88f	343	13	consists	consist	VBZ
cord-018804-wj35q88f	343	14	in	in	IN
cord-018804-wj35q88f	343	15	the	the	DT
cord-018804-wj35q88f	343	16	increase	increase	NN
cord-018804-wj35q88f	343	17	of	of	IN
cord-018804-wj35q88f	343	18	the	the	DT
cord-018804-wj35q88f	343	19	error	error	NN
cord-018804-wj35q88f	343	20	rate	rate	NN
cord-018804-wj35q88f	343	21	of	of	IN
cord-018804-wj35q88f	343	22	viral	viral	JJ
cord-018804-wj35q88f	343	23	replication	replication	NN
cord-018804-wj35q88f	343	24	above	above	IN
cord-018804-wj35q88f	343	25	the	the	DT
cord-018804-wj35q88f	343	26	threshold	threshold	NN
cord-018804-wj35q88f	343	27	that	that	WDT
cord-018804-wj35q88f	343	28	prevents	prevent	VBZ
cord-018804-wj35q88f	343	29	further	further	JJ
cord-018804-wj35q88f	343	30	transmission	transmission	NN
cord-018804-wj35q88f	343	31	of	of	IN
cord-018804-wj35q88f	343	32	genetic	genetic	JJ
cord-018804-wj35q88f	343	33	information	information	NN
cord-018804-wj35q88f	343	34	.	.	.
cord-018804-wj35q88f	344	1	The	the	DT
cord-018804-wj35q88f	344	2	difficulty	difficulty	NN
cord-018804-wj35q88f	344	3	to	to	TO
cord-018804-wj35q88f	344	4	apply	apply	VB
cord-018804-wj35q88f	344	5	lethal	lethal	JJ
cord-018804-wj35q88f	344	6	mutagenesis	mutagenesis	NN
cord-018804-wj35q88f	344	7	to	to	IN
cord-018804-wj35q88f	344	8	the	the	DT
cord-018804-wj35q88f	344	9	treatment	treatment	NN
cord-018804-wj35q88f	344	10	of	of	IN
cord-018804-wj35q88f	344	11	viral	viral	JJ
cord-018804-wj35q88f	344	12	infections	infection	NNS
cord-018804-wj35q88f	344	13	largely	largely	RB
cord-018804-wj35q88f	344	14	rely	rely	VBP
cord-018804-wj35q88f	344	15	,	,	,
cord-018804-wj35q88f	344	16	as	as	IN
cord-018804-wj35q88f	344	17	it	-PRON-	PRP
cord-018804-wj35q88f	344	18	happens	happen	VBZ
cord-018804-wj35q88f	344	19	with	with	IN
cord-018804-wj35q88f	344	20	other	other	JJ
cord-018804-wj35q88f	344	21	antiviral	antiviral	JJ
cord-018804-wj35q88f	344	22	drugs	drug	NNS
cord-018804-wj35q88f	344	23	,	,	,
cord-018804-wj35q88f	344	24	on	on	IN
cord-018804-wj35q88f	344	25	the	the	DT
cord-018804-wj35q88f	344	26	emergence	emergence	NN
cord-018804-wj35q88f	344	27	of	of	IN
cord-018804-wj35q88f	344	28	resistant	resistant	JJ
cord-018804-wj35q88f	344	29	mutants	mutant	NNS
cord-018804-wj35q88f	344	30	,	,	,
cord-018804-wj35q88f	344	31	which	which	WDT
cord-018804-wj35q88f	344	32	in	in	IN
cord-018804-wj35q88f	344	33	this	this	DT
cord-018804-wj35q88f	344	34	case	case	NN
cord-018804-wj35q88f	344	35	would	would	MD
cord-018804-wj35q88f	344	36	probably	probably	RB
cord-018804-wj35q88f	344	37	be	be	VB
cord-018804-wj35q88f	344	38	those	those	DT
cord-018804-wj35q88f	344	39	carrying	carry	VBG
cord-018804-wj35q88f	344	40	high	high	JJ
cord-018804-wj35q88f	344	41	fidelity	fidelity	NN
cord-018804-wj35q88f	344	42	polymerases	polymerase	NNS
cord-018804-wj35q88f	344	43	.	.	.
cord-018804-wj35q88f	345	1	The	the	DT
cord-018804-wj35q88f	345	2	knowledge	knowledge	NN
cord-018804-wj35q88f	345	3	of	of	IN
cord-018804-wj35q88f	345	4	the	the	DT
cord-018804-wj35q88f	345	5	exact	exact	JJ
cord-018804-wj35q88f	345	6	mechanisms	mechanism	NNS
cord-018804-wj35q88f	345	7	leading	lead	VBG
cord-018804-wj35q88f	345	8	a	a	DT
cord-018804-wj35q88f	345	9	population	population	NN
cord-018804-wj35q88f	345	10	to	to	TO
cord-018804-wj35q88f	345	11	error	error	VB
cord-018804-wj35q88f	345	12	catastrophe	catastrophe	NN
cord-018804-wj35q88f	345	13	implies	imply	VBZ
cord-018804-wj35q88f	345	14	a	a	DT
cord-018804-wj35q88f	345	15	detailed	detailed	JJ
cord-018804-wj35q88f	345	16	study	study	NN
cord-018804-wj35q88f	345	17	of	of	IN
cord-018804-wj35q88f	345	18	the	the	DT
cord-018804-wj35q88f	345	19	composition	composition	NN
cord-018804-wj35q88f	345	20	and	and	CC
cord-018804-wj35q88f	345	21	structure	structure	NN
cord-018804-wj35q88f	345	22	of	of	IN
cord-018804-wj35q88f	345	23	the	the	DT
cord-018804-wj35q88f	345	24	mutant	mutant	JJ
cord-018804-wj35q88f	345	25	spectrum	spectrum	NN
cord-018804-wj35q88f	345	26	of	of	IN
cord-018804-wj35q88f	345	27	the	the	DT
cord-018804-wj35q88f	345	28	quasi	quasi	JJ
cord-018804-wj35q88f	345	29	-	-	NNS
cord-018804-wj35q88f	345	30	species	specie	NNS
cord-018804-wj35q88f	345	31	.	.	.
cord-018804-wj35q88f	346	1	In	in	IN
cord-018804-wj35q88f	346	2	this	this	DT
cord-018804-wj35q88f	346	3	sense	sense	NN
cord-018804-wj35q88f	346	4	,	,	,
cord-018804-wj35q88f	346	5	the	the	DT
cord-018804-wj35q88f	346	6	comparison	comparison	NN
cord-018804-wj35q88f	346	7	with	with	IN
cord-018804-wj35q88f	346	8	the	the	DT
cord-018804-wj35q88f	346	9	structure	structure	NN
cord-018804-wj35q88f	346	10	of	of	IN
cord-018804-wj35q88f	346	11	bottlenecked	bottlenecked	JJ
cord-018804-wj35q88f	346	12	populations	population	NNS
cord-018804-wj35q88f	346	13	that	that	WDT
cord-018804-wj35q88f	346	14	have	have	VBP
cord-018804-wj35q88f	346	15	accumulated	accumulate	VBN
cord-018804-wj35q88f	346	16	a	a	DT
cord-018804-wj35q88f	346	17	large	large	JJ
cord-018804-wj35q88f	346	18	number	number	NN
cord-018804-wj35q88f	346	19	of	of	IN
cord-018804-wj35q88f	346	20	mutations	mutation	NNS
cord-018804-wj35q88f	346	21	still	still	RB
cord-018804-wj35q88f	346	22	compatible	compatible	JJ
cord-018804-wj35q88f	346	23	with	with	IN
cord-018804-wj35q88f	346	24	survival	survival	NN
cord-018804-wj35q88f	346	25	can	can	MD
cord-018804-wj35q88f	346	26	help	help	VB
cord-018804-wj35q88f	346	27	to	to	TO
cord-018804-wj35q88f	346	28	design	design	VB
cord-018804-wj35q88f	346	29	new	new	JJ
cord-018804-wj35q88f	346	30	strategies	strategy	NNS
cord-018804-wj35q88f	346	31	for	for	IN
cord-018804-wj35q88f	346	32	the	the	DT
cord-018804-wj35q88f	346	33	extinction	extinction	NN
cord-018804-wj35q88f	346	34	of	of	IN
cord-018804-wj35q88f	346	35	infectivity	infectivity	NN
cord-018804-wj35q88f	346	36	.	.	.
cord-018804-wj35q88f	347	1	Fields	field	NNS
cord-018804-wj35q88f	347	2	Virology	Virology	NNP
cord-018804-wj35q88f	347	3	Proc	Proc	NNP
cord-018804-wj35q88f	347	4	.	.	.
cord-018804-wj35q88f	348	1	Natl	Natl	NNP
cord-018804-wj35q88f	348	2	.	.	.
cord-018804-wj35q88f	349	1	Acad	Acad	NNP
cord-018804-wj35q88f	349	2	.	.	.
cord-018804-wj35q88f	350	1	Sci	Sci	NNP
cord-018804-wj35q88f	350	2	.	.	.
cord-018804-wj35q88f	351	1	USA	USA	NNP
cord-018804-wj35q88f	351	2	Variability	Variability	NNP
cord-018804-wj35q88f	351	3	of	of	IN
cord-018804-wj35q88f	351	4	RNA	RNA	NNP
cord-018804-wj35q88f	351	5	Genomes	Genomes	NNPS
cord-018804-wj35q88f	351	6	Quasispecies	Quasispecies	NNPS
cord-018804-wj35q88f	351	7	and	and	CC
cord-018804-wj35q88f	351	8	RNA	RNA	NNP
cord-018804-wj35q88f	351	9	Virus	Virus	NNP
cord-018804-wj35q88f	351	10	Evolution	Evolution	NNP
cord-018804-wj35q88f	351	11	:	:	:
cord-018804-wj35q88f	352	1	Principles	principle	NNS
cord-018804-wj35q88f	352	2	and	and	CC
cord-018804-wj35q88f	352	3	Consequences	Consequences	NNPS
cord-018804-wj35q88f	352	4	HIV-1	HIV-1	NNP
cord-018804-wj35q88f	352	5	Sequence	sequence	NN
cord-018804-wj35q88f	352	6	Compendium	Compendium	NNP
cord-018804-wj35q88f	352	7	Infectious	Infectious	NNP
cord-018804-wj35q88f	352	8	Diseases	disease	NNS
cord-018804-wj35q88f	352	9	of	of	IN
cord-018804-wj35q88f	352	10	Humans	Humans	NNPS
cord-018804-wj35q88f	352	11	:	:	:
cord-018804-wj35q88f	352	12	Dynamics	dynamic	NNS
cord-018804-wj35q88f	352	13	and	and	CC
cord-018804-wj35q88f	352	14	Control	Control	NNP
cord-018804-wj35q88f	352	15	Proc	Proc	NNP
cord-018804-wj35q88f	352	16	.	.	.
cord-018804-wj35q88f	353	1	Natl	Natl	NNP
cord-018804-wj35q88f	353	2	.	.	.
cord-018804-wj35q88f	354	1	Acad	Acad	NNP
cord-018804-wj35q88f	354	2	.	.	.
cord-018804-wj35q88f	355	1	Sci	Sci	NNP
cord-018804-wj35q88f	355	2	.	.	NNP
cord-018804-wj35q88f	355	3	USA	USA	NNP
cord-018804-wj35q88f	355	4	Proc	Proc	NNP
cord-018804-wj35q88f	355	5	.	.	.
cord-018804-wj35q88f	356	1	Natl	Natl	NNP
cord-018804-wj35q88f	356	2	.	.	.
cord-018804-wj35q88f	357	1	Acad	Acad	NNP
cord-018804-wj35q88f	357	2	.	.	.
cord-018804-wj35q88f	358	1	Sci	Sci	NNP
cord-018804-wj35q88f	358	2	.	.	NNP
cord-018804-wj35q88f	358	3	USA	USA	NNP
cord-018804-wj35q88f	358	4	Proc	Proc	NNP
cord-018804-wj35q88f	358	5	.	.	.
cord-018804-wj35q88f	359	1	Natl	Natl	NNP
cord-018804-wj35q88f	359	2	.	.	.
cord-018804-wj35q88f	360	1	Acad	Acad	NNP
cord-018804-wj35q88f	360	2	.	.	.
cord-018804-wj35q88f	361	1	Sci	Sci	NNP
cord-018804-wj35q88f	361	2	.	.	NNP
cord-018804-wj35q88f	361	3	USA	USA	NNP
cord-018804-wj35q88f	361	4	Proc	Proc	NNP
cord-018804-wj35q88f	361	5	.	.	.
cord-018804-wj35q88f	362	1	Natl	Natl	NNP
cord-018804-wj35q88f	362	2	.	.	.
cord-018804-wj35q88f	363	1	Acad	Acad	NNP
cord-018804-wj35q88f	363	2	.	.	.
cord-018804-wj35q88f	364	1	Sci	Sci	NNP
cord-018804-wj35q88f	364	2	.	.	NNP
cord-018804-wj35q88f	364	3	USA	USA	NNP
cord-018804-wj35q88f	364	4	Proc	Proc	NNP
cord-018804-wj35q88f	364	5	.	.	.
cord-018804-wj35q88f	365	1	Natl	Natl	NNP
cord-018804-wj35q88f	365	2	.	.	.
cord-018804-wj35q88f	366	1	Acad	Acad	NNP
cord-018804-wj35q88f	366	2	.	.	.
cord-018804-wj35q88f	367	1	Sci	Sci	NNP
cord-018804-wj35q88f	367	2	.	.	NNP
cord-018804-wj35q88f	367	3	USA	USA	NNP
cord-018804-wj35q88f	367	4	Proc	Proc	NNP
cord-018804-wj35q88f	367	5	.	.	.
cord-018804-wj35q88f	368	1	Natl	Natl	NNP
cord-018804-wj35q88f	368	2	.	.	.
cord-018804-wj35q88f	369	1	Acad	Acad	NNP
cord-018804-wj35q88f	369	2	.	.	.
cord-018804-wj35q88f	370	1	Sci	Sci	NNP
cord-018804-wj35q88f	370	2	.	.	NNP
cord-018804-wj35q88f	370	3	USA	USA	NNP
cord-018804-wj35q88f	370	4	Proc	Proc	NNP
cord-018804-wj35q88f	370	5	.	.	.
cord-018804-wj35q88f	371	1	Natl	Natl	NNP
cord-018804-wj35q88f	371	2	.	.	.
cord-018804-wj35q88f	372	1	Acad	Acad	NNP
cord-018804-wj35q88f	372	2	.	.	.
cord-018804-wj35q88f	373	1	Sci	Sci	NNP
cord-018804-wj35q88f	373	2	.	.	.
cord-018804-wj35q88f	374	1	USA	USA	NNP
cord-018804-wj35q88f	374	2	Microbes	microbe	NNS
cord-018804-wj35q88f	374	3	Infect	infect	VBP
cord-018804-wj35q88f	374	4	Proc	proc	NN
cord-018804-wj35q88f	374	5	.	.	.
cord-018804-wj35q88f	375	1	Natl	Natl	NNP
cord-018804-wj35q88f	375	2	.	.	.
cord-018804-wj35q88f	376	1	Acad	Acad	NNP
cord-018804-wj35q88f	376	2	.	.	.
cord-018804-wj35q88f	377	1	Sci	Sci	NNP
cord-018804-wj35q88f	377	2	.	.	NNP
cord-018804-wj35q88f	377	3	USA	USA	NNP
cord-018804-wj35q88f	377	4	Proc	Proc	NNP
cord-018804-wj35q88f	377	5	.	.	.
cord-018804-wj35q88f	378	1	Natl	Natl	NNP
cord-018804-wj35q88f	378	2	.	.	.
cord-018804-wj35q88f	379	1	Acad	Acad	NNP
cord-018804-wj35q88f	379	2	.	.	.
cord-018804-wj35q88f	380	1	Sci	Sci	NNP
cord-018804-wj35q88f	380	2	.	.	NNP
cord-018804-wj35q88f	380	3	USA	USA	NNP
cord-018804-wj35q88f	381	1	The	the	DT
cord-018804-wj35q88f	381	2	author	author	NN
cord-018804-wj35q88f	381	3	thanks	thank	VBZ
cord-018804-wj35q88f	382	1	S.C.	South Carolina	NNP
cord-018804-wj35q88f	382	2	Manrubia	Manrubia	NNP
cord-018804-wj35q88f	382	3	,	,	,
cord-018804-wj35q88f	382	4	C.	C.	NNP
cord-018804-wj35q88f	382	5	Escarmís	Escarmís	NNP
cord-018804-wj35q88f	382	6	,	,	,
cord-018804-wj35q88f	382	7	A.	A.	NNP
cord-018804-wj35q88f	382	8	Grande	Grande	NNP
cord-018804-wj35q88f	382	9	-	-	HYPH
cord-018804-wj35q88f	382	10	Pérez	Pérez	NNP
cord-018804-wj35q88f	382	11	,	,	,
cord-018804-wj35q88f	382	12	J.Pérez	J.Pérez	NNP
cord-018804-wj35q88f	382	13	-	-	HYPH
cord-018804-wj35q88f	382	14	Mercader	Mercader	NNP
cord-018804-wj35q88f	382	15	and	and	CC
cord-018804-wj35q88f	382	16	E.	E.	NNP
cord-018804-wj35q88f	382	17	Domingo	Domingo	NNP
cord-018804-wj35q88f	382	18	for	for	IN
cord-018804-wj35q88f	382	19	valuable	valuable	JJ
cord-018804-wj35q88f	382	20	suggestions	suggestion	NNS
cord-018804-wj35q88f	382	21	and	and	CC
cord-018804-wj35q88f	382	22	their	-PRON-	PRP$
cord-018804-wj35q88f	382	23	participation	participation	NN
cord-018804-wj35q88f	382	24	in	in	IN
cord-018804-wj35q88f	382	25	many	many	JJ
cord-018804-wj35q88f	382	26	of	of	IN
cord-018804-wj35q88f	382	27	the	the	DT
cord-018804-wj35q88f	382	28	studies	study	NNS
cord-018804-wj35q88f	382	29	detailed	detail	VBN
cord-018804-wj35q88f	382	30	in	in	IN
cord-018804-wj35q88f	382	31	this	this	DT
cord-018804-wj35q88f	382	32	chapter	chapter	NN
cord-018804-wj35q88f	382	33	.	.	.
cord-018804-wj35q88f	383	1	J.E.	J.E.	NNP
cord-018804-wj35q88f	383	2	González	González	NNP
cord-018804-wj35q88f	383	3	-	-	HYPH
cord-018804-wj35q88f	383	4	Pastor	Pastor	NNP
cord-018804-wj35q88f	383	5	is	be	VBZ
cord-018804-wj35q88f	383	6	also	also	RB
cord-018804-wj35q88f	383	7	acknowledged	acknowledge	VBN
cord-018804-wj35q88f	383	8	for	for	IN
cord-018804-wj35q88f	383	9	critical	critical	JJ
cord-018804-wj35q88f	383	10	reading	reading	NN
cord-018804-wj35q88f	383	11	of	of	IN
cord-018804-wj35q88f	383	12	the	the	DT
cord-018804-wj35q88f	383	13	manuscript	manuscript	NN
cord-018804-wj35q88f	383	14	.	.	.
cord-018804-wj35q88f	384	1	Work	work	NN
cord-018804-wj35q88f	384	2	at	at	IN
cord-018804-wj35q88f	384	3	Centro	Centro	NNP
cord-018804-wj35q88f	384	4	de	de	NNP
cord-018804-wj35q88f	384	5	Astrobiología	Astrobiología	NNP
cord-018804-wj35q88f	384	6	has	have	VBZ
cord-018804-wj35q88f	384	7	been	be	VBN
cord-018804-wj35q88f	384	8	supported	support	VBN
cord-018804-wj35q88f	384	9	by	by	IN
cord-018804-wj35q88f	384	10	INTA	INTA	NNP
cord-018804-wj35q88f	384	11	(	(	-LRB-
cord-018804-wj35q88f	384	12	Instituto	Instituto	NNP
cord-018804-wj35q88f	384	13	Nacional	Nacional	NNP
cord-018804-wj35q88f	384	14	de	de	NNP
cord-018804-wj35q88f	384	15	Técnica	Técnica	NNP
cord-018804-wj35q88f	384	16	Aeroespacial	Aeroespacial	NNP
cord-018804-wj35q88f	384	17	)	)	-RRB-
cord-018804-wj35q88f	384	18	.	.	.