id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310406-5pvln91x	Asbury, Thomas M	Genome3D: A viewer-model framework for integrating and visualizing multi-scale epigenomic information within a three-dimensional genome	2010-09-02		.txt	text/plain	3014	189	44	RESULTS: We have applied object-oriented technology to develop a downloadable visualization tool, Genome3D, for integrating and displaying epigenomic data within a prescribed three-dimensional physical model of the human genome. In addition, in spite of the many recent efforts to measure and model the genome structure at various resolutions and detail [3] [4] [5] [6] [7] [8] [9] [10] , little work has focused on combining these models into a plausible aggregate, or has taken advantage of the large amount of genomic and epigenomic data available from new high-throughput approaches. The viewer is designed to display data from multiple scales and uses a hierarchical model of the relative positions of all nucleotide atoms in the cell nucleus, i.e., the complete physical genome. An integrated physical genome model can show the interplay between histone modifications and other genomic data, such as SNPs, DNA methylation, the structure of gene, promoter and transcription machinery, etc. In addition to epigenomic data, the physical genome model also provides a platform to visualize highthroughput gene expression data and its interplay with global binding information of transcription factors.	./cache/cord-310406-5pvln91x.txt	./txt/cord-310406-5pvln91x.txt