id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267714-ji88tvsl	JAKUPCIAK, JOHN P.	Biological agent detection technologies	2009-04-21		.txt	text/plain	3526	175	35	PCR-based methods have critical limitations, since they depend on a priori knowledge of what sequence to detect in a sample further complicated by recent demonstrations of greater variability in genomic sequence than expected. A platform for genome identification of a specimen from any source must not only be sensitive and specific, but must also detect a variety of pathogens with high accuracy, including modified or previously uncharacterized agents, and this challenge is daunting when identification must be achieved using nucleic acids in a complex sample matrix. The build-out of genome identification DNA sequencing technology in the form of practical instrumentation will be achieved by incorporating the critical requirements for accurate long reads, without dependency for template amplification, capable of manipulating terabytes of data to provide reliable and useful identification of genetic sequences within any unknown sample, whether clinical, environmental, or other type of specimen.	./cache/cord-267714-ji88tvsl.txt	./txt/cord-267714-ji88tvsl.txt