id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004123-1s8kuno2	Jaiswal, Arun Kumar	The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis	2020-01-10		.txt	text/plain	5934	363	51	title: The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis pallidum strains isolated from different parts of the world and a diverse range of hosts were comparatively analysed using pan-genomic strategy. pertenue, we found differences in the presence/absence of pathogenicity islands (PAIs) and genomic islands (GIs) on subsp.-based study. In this work, we perform a pan-genome approach to better understand the differences of Treponema pallidum infections in the broad spectrum and how genome plasticity is related to the symptom patterns. Finally, we provide insights into the specific subsets (singletons and the panand core genomes) of 53 genomes of T pallidum strains and correlate these subsets with the plasticity of pathogenicity islands and virulence genes. The subspecies responsible for non-venereal syphilis is Treponema pallidum subsp. Genes which are present in pallidum subspecies pathogenicity islands (PAIs) or genomic islands (GIs) are absent in the subspecies endemicum and pertenue.	./cache/cord-004123-1s8kuno2.txt	./txt/cord-004123-1s8kuno2.txt