id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305177-i71z2sf4	Neshat, Sarah Y	Gene delivery for immunoengineering	2020-06-15		.txt	text/plain	5261	234	32	Major strategies that have been explored for cancer immunotherapy [7] center on increasing the immunogenicity of the tumor microenvironment, enhancing the ability of antigen-presenting cells (APCs) to be activated, improving the activation of T cells and other lymphocytes in the context of the tumor while lessening the effect of suppressive immune cells, and vaccinating the patient with a tumor-specific antigen in order to generate a tumor-targeted immune response ( Figure 1 ). Additionally, anti-viral vaccines have been engineered with self-amplifying mRNA (SAM) encapsulated in lipid nanoparticles and show an induced type 1 IFN Gene delivery for immunoengineering Neshat, Tzeng and Green 7 response locally when compared to TLR7 agonists [45 ] . Using lipid nanoparticles, the authors describe an antigen-agnostic combination immunotherapy via direct intratumoral injection of mRNA encoding immunostimulatory genes, leading to anti-tumor effect even at sites distant from the local treatment site.	./cache/cord-305177-i71z2sf4.txt	./txt/cord-305177-i71z2sf4.txt