id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280897-el7bdkcf	Wang, Hai-Fang	Relationship between mRNA stability and intron presence	2007-03-02		.txt	text/plain	3037	169	55	By analyzing the genome-wide data of mRNA stability published by someone previously, we found that human intron-containing genes have more stable mRNAs than intronless genes, and the Arabidopsis thaliana genes with the most unstable mRNAs have fewer introns than other genes in the genome. [10] found that insertion of a 138-bp intron into SARS-CoV spike protein gene can enhance the protein expression in mammalian cells, but the mRNAs exhibited similar decay rates as the intronless control mRNA. As a stable mRNA can be measured by lower decay rate or longer half-life, our analyses of different sources of data consistently showed that the mRNAs of intron-containing genes are more stable than those of intronless genes in human cells. We found that the mRNAs of intronless genes are less stable (i.e. have higher decay rates or shorter half-lives) than the intron-containing genes with similar mRNA lengths and functions (Fig. 1) .	./cache/cord-280897-el7bdkcf.txt	./txt/cord-280897-el7bdkcf.txt