id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103505-9adtbwp2	Hale, A. T.	The genetic architecture of human infectious diseases and pathogen-induced cellular phenotypes	2020-07-21		.txt	text/plain	1408	105	41	Host genetic variation is likely to contribute to ID risk and downstream clinical outcomes, but there is a need for a genetics-anchored framework to decipher molecular mechanisms of disease risk, infer causal effect on potential complications, and identify instruments for drug target discovery. The rich resource of genetic information linked to serologic tests and pathogen cultures from bronchoalveolar lavage, sputum, sinus/nasopharyngeal, tracheal, and blood samples (up to 7,699 positive pathogen cultures across 92 unique genera) that we leverage provides a platform to interrogate the genetic basis of compartment-specific infection and colonization. To accelerate insights into cellular mechanisms, we develop a TWAS repository of gene-level associations in a broad collection of human tissues with 79 pathogen-exposure induced cellular phenotypes as a discovery and replication platform. We hypothesized that tissue expression profiling of ID-associated genes 216 can provide additional insights into disease etiologies and mechanisms. These data identify specific molecular mechanisms across ID traits with critical 239 regulatory roles (e.g., protein modifications) in host response among the ID-associated genes.	./cache/cord-103505-9adtbwp2.txt	./txt/cord-103505-9adtbwp2.txt