# pos

id: cord-288079-rr8h5dgy
pos: NNP
token:
  gouv.fr/fr/datasets/donnees-des-urgences-hospitalieres-et-de-sosmedecins-relatives-a-lepidemie-de-covid-19

lemma:
  gouv.fr/fr/datasets/donnees-des-urgences-hospitalieres-et-de-sosmedecins-relatives-a-lepidemie-de-covid-19


# ent

id: cord-000425-isw6jeir
type: CELL_TYPE
entity:
  total white blood cells WBC CD4 T lymphocyte CD8a T lymphocyte and B lymphocyte subsets 15 16 17 delayed type hypersensitivity reaction 15 18 lymphocyte proliferative response 15 interleukin 2 IL2


id: cord-000425-isw6jeir
type: DNA
entity:
  allophycocyanin conjugated anti mouse IgG1 BD Biosciences France phycoerythrin conjugated antimouse IgG2a Southern Biotech France FITC conjugated antimouse IgG2b Southern Biotech France APC conjugated antimouse IgG1 BD Biosciences France phycoerythrin conjugated anti rat IgG2a BD Pharmingen France or phycoerythrinconjugated anti mouse IgG2b


id: cord-000425-isw6jeir
type: PROTEIN
entity:
  anti swine polyclonal antibody goat anti porcine IL 10 R and D System France Streptavidin horseradish peroxidase Biosource


id: cord-285187-1h5tjs0r
type: ORG
entity:
  Scotland S Digital Health Care Strategy n d Danish Ministry of Health South African National Department of Health National Digital Health Strategy


id: cord-264203-7dnz9yaa
type: DNA
entity:
  1645 1659 1673 1687 1701 1715 1729 1743 1757 1771 1785 1799 1813 1827 1841 1855 1869 1883 1897 1911 1925 1939 1953 1967 1981 Emergence


id: cord-264203-7dnz9yaa
type: CHEMICAL
entity:
  1659 1673 1687 1701 1715 1729 1743 1757 1771 1785 1799 1813 1827 1841 1855 1869 1883 1897 1911 1925 1939 1953 1967 1981


id: cord-272085-4mqc8mqd
type: ORG
entity:
  Healthcare Demand Early Estimations of the Impact of General Lockdown to Control the Covid 19 Epidemic


id: cord-275827-r86ygqmy
type: DISEASE
entity:
  Drug Dependence or Abuse ILIADDA derivation and validation of a model Les CAARUD lieux privilégiés d émergence de signaux pour l addictovigilance


id: cord-267867-q52nvn0n
type: DNA
entity:
  ABI 3700 capillary DNA sequencer Applied Biosystems Courtaboeuf France En 5 3 transfected cells 2 10 5


id: cord-267867-q52nvn0n
type: PROTEIN
entity:
  HCV 5 NTR FP 5 CGGGAGAGC CATAGTGG 3 RP 5 AGTACCACAAGGCCTTTCG 3 Probe 5 FAM CTGCGGAACCGGTGAGTACAC TAMRA 3


id: cord-288079-rr8h5dgy
type: PROTEIN
entity:
  medRxiv Tian H Liu Y Li Y Wu C H Chen B Kraemer M U G Li B Cai J Xu B Yang Q Wang B Yang P Cui Y Song Y Zheng P Wang Q Bjornstad O N Yang R Grenfell B T Pybus O G


id: cord-320636-mvtux07x
type: DNA
entity:
  UK tenth update Prise en charge par les médicins de ville des patients atteints de COVID 19 en phase de déconfinement Testing


id: cord-318701-f9j13fsc
type: ORG
entity:
  the World Health Organization French Government French Agency of Public Health French National Council of Nurses


id: cord-292475-jrl1fowa
type: PERSON
entity:
  ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi ffi


id: cord-292475-jrl1fowa
type: ORG
entity:
  Image Deconvolution and Reconstruction Different Epidemic Curves for Severe Acute Respiratory Syndrome


id: cord-320773-zisujjsx
type: ORG
entity:
  Oxford COVID 19 Government Response Tracker Blavatnik School of Government Temporary Reintroduction of Border Control Tracking


id: cord-320773-zisujjsx
type: ORG
entity:
  the University of Hamburg Erasmus University Rotterdam and Nova School of Business Economics Lisbon Chair BPI Fundação La Caixa


id: cord-014685-ihh30q6f
type: PROTEIN
entity:
  hydrophobic helical peptide P Chetal V Chauhan D Sahal International Centre For Genetic Engineering Biotechnology


id: cord-014685-ihh30q6f
type: PROTEIN
entity:
  post termination complex P Guo L Zhang Y Feng G Jing Institute of Biophysics Chinese Academy of Sciences National Laboratory of Biomacromolecules Beijing China Ribosome recycling factor RRF


id: cord-014685-ihh30q6f
type: PROTEIN
entity:
  L chain apoferritin K Yoshizawa 1 K Iwahori 3 Y Mishima 1 I Yamashita 2 1 CREST JST 2 ATRL Matsushita 3 Nara Institute of Science and Technology The denaturation of apoferritin


id: cord-014685-ihh30q6f
type: PROTEIN
entity:
  carbonic anhydrase H M Becker J W Deitmer Abt Allgem Zoologie TU Kaiserslautern 67663 Kaiserslautern


id: cord-014685-ihh30q6f
type: PROTEIN
entity:
  prostaglandin endoperoxide H2 synthase Prostaglandin endoperoxide H 2 synthases 1 and 2 PGHS 1 and 2


id: cord-014685-ihh30q6f
type: PROTEIN
entity:
  nucleoprotein complex K Zupán 1 L Herényi 1 K Tóth 2 Z Majer 3 G Csík 1 1 Institute of Biophysics and Radiation Biology Semmelweis Univ Budapest Hungary 2 Biophysics of Macromolecules German Cancer Research Center Heidelberg Germany 3 Department of Organic Chemistry Eötvös Loránd


id: cord-014685-ihh30q6f
type: DNA
entity:
  HIV 1 genomic RNA S Bernacchi 2 E Ennifar 1 K Toth 2 P Walter 1 J Langowski 2 P Dumas 1 1 CNRS UPR 9002 Strasbourg France 2 DKFZ Heidelberg Germany


id: cord-014685-ihh30q6f
type: DNA
entity:
  CUG repeats Y Sato K Kimura A Takénaka Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology Yokohama Japan


id: cord-014685-ihh30q6f
type: GGP
entity:
  Refs 1 2 3 XAS spectroscopy results show that there are two different structures of the metal binding site


id: cord-014685-ihh30q6f
type: CHEBI
entity:
  cholesterol proteoliposomes M Berchel 1 J Jeftic 1 T Benvegnu 1 J Y Thepot 2 D Plusquellec 1 1 ENSCR


id: cord-014685-ihh30q6f
type: GGP
entity:
  speci c conductance s of aqueous solution of electrolytes viz NaF NaCl NaNO 3 Na2SO 4 KF KCl KNO 3 K 2 SO 4 MgCl 2 CaCl 2 FeCl 3 MnCl 2 CrCl 3 CuCl 2 CoCl 2


id: cord-014685-ihh30q6f
type: CL
entity:
  stem bulge stem region of DIS39 and the solution structures of DIS39 in the kissing loop and extendedduplex


id: cord-014685-ihh30q6f
type: PRODUCT
entity:
  J C Holyoake M S Sansom Biochemistry Department University of Oxford South Parks Road Oxford OX1 3QU


id: cord-014685-ihh30q6f
type: ORG
entity:
  Department of Animal Physiology and Biophysics Faculty of Biology University of Bucharest 2 Department of Biochemistry Faculty of Biology University of Bucharest Bucharest Romania Hypericin Hyp


id: cord-014685-ihh30q6f
type: WORK_OF_ART
entity:
  Faculty of Science and Technology Keio University Japan 2 Japan Synchrotron Radiation Research Institute


id: cord-014685-ihh30q6f
type: ORG
entity:
  NMR 2 Department of Surgery 3 Department of Radiotherapy All India Institute of Medical Sciences New Delhi India Diffusion


id: cord-014685-ihh30q6f
type: ORG
entity:
  Applied Physics College of Humanities and Sciences Nihon University 2 Department of Biophysics and Life


id: cord-014685-ihh30q6f
type: ORG
entity:
  University of Helsinki Finland 2 Institute of Biotechnology University of Helsinki Finland Molecular


id: cord-014685-ihh30q6f
type: CHEMICAL
entity:
  Ruysshaert 2 B Bechinger 1 1 ULP CNRS Chemistry 4 rue Blaise Pascal 67070 Strasbourg 2 Université Libre Campus Plaine


id: cord-253801-y1nherse
type: DNA
entity:
  Panton Valentine leukocidin positive methicillin resistant Staphylococcus aureus Antimicrobial resistance and molecular epidemiology of vancomycin resistant enterococci


id: cord-253801-y1nherse
type: CHEMICAL
entity:
  années 1990 dans des populations jeunes sans facteur de risque Ces souches étaient génétiquement différentes de celles provenant des hôpitaux


id: cord-331509-p19dg1jw
type: PROTEIN
entity:
  Beitrag zur kollektiven Behandlung pharmakologisher Reihenversuche MAFFT multiple sequence alignment software version 7


id: cord-344984-mg779mix
type: DISEASE
entity:
  importés de choléra a été élaboré entre institutions lien 1 Ce Dans le cas de menaces avérées par leur sévérité ou leur diffusion mais insuffisamment caractérisées l évaluation l alerte


id: cord-335252-med3c01q
type: GPE
entity:
  the United States Psychiatric Effects of Solitary Confinement Reforming Punishment Psychological Limits


id: cord-335252-med3c01q
type: CHEMICAL
entity:
  plusieurs facteurs comme la surpopulation ou le cadre de fonctionnement sécuritaire peuvent constituer des freins


id: cord-337744-g17qe8fi
type: DNA
entity:
  ANR projects EVALCOVID 19 ANR 20 COVI 0007 SPHINX ANR 17 CE36 0008 05 and DATAREDUX ANR 19 CE46 0008


id: cord-337744-g17qe8fi
type: CELL_LINE
entity:
  MOOD H2020 874850 REACTing COVID 19 modeling grant We thank Luca Ferreri Sylvain Bourgeois Erwan Le Quentrec Zbigniew Smoreda Chiara Poletto Pierre Yves Boëlle


id: cord-355549-6xnjj5h5
type: CELL_LINE
entity:
  Coronavirus 2019 COVID 19 Pandemic Acute Inpatient and Maintenance Outpatient Experiences An Analysis on the Clinical Features of MHD Patients with Coronavirus Disease 2019 A Single Center Study Deisolation of COVID 19 positive hemodialysis patients


id: cord-347244-abxv2mkz
type: SO
entity:
  ORF3 region forward primer HEVORF3 S 5 GGTGGTTTCTGGGGTGAC 3 reverse primer HEVORF3 AS 5 AGGGGTTGGTTGGATGAA 3 and probe


id: cord-347244-abxv2mkz
type: CHEMICAL
entity:
  Dordogne n 7 Finistère n 3 Deux Sèvres n 2 Loire Atlantique n 2 Haute Garonne n 1 Charentes n 1 Morbihan n 1 and Pyrénées Orientales n 1 Table 1 The number of


id: cord-014538-6a2pviol
type: PROTEIN
entity:
  Bruno Neuville Mathilde D ortho Marie Pia Bouadma Lila Rouvel Tallec Anny Rudler Marika Weiss Nicolas Perlbarg Vincent Galanaud Damien Thabut Dominique Rachdi Emna


id: cord-014538-6a2pviol
type: DNA
entity:
  Louf Durier Aurore Tapponnier Romain Louis Bruno Forel Jean Marie Bisbal Magali Lehingue Samuel Rambaud Romain


id: cord-014538-6a2pviol
type: DISEASE
entity:
  Deransy Romain Brisson Hélène Monsel Antoine Conti Filomena Scatton Olivier Langeron Olivier Ghezala Hassen Ben Snouda Salah


id: cord-014538-6a2pviol
type: DISEASE
entity:
  neoplasms breast lung ovarian urologic gastrointestinal digestive system abdominal brain carcinoid tumor sarcoma testicular seminoma


id: cord-015334-8p124rwp
type: PROTEIN
entity:
  B C A A Design Case report Setting Department of Pharmacy Hospital Charles Nicolle Rouen Main Outcome Measures Case report Results One patient with classical M S U D


id: cord-015334-8p124rwp
type: PROTEIN
entity:
  albumin 2 4 vs 3 1 g dL total proteins 4 4 vs 6 2 g dL total serum cholesterol 88 vs 106 mg dL total lymphocite count 6 9 vs 12 9 and prealbumin 10 5 vs 16 1


id: cord-015334-8p124rwp
type: GGP
entity:
  Pseudomonas aeruginosa 1 ceftazidime 2 g q8 h gentamicin 5 mg Kg qd 2 ceftazidime 2 g q8 h ciprofloxacin


id: cord-015334-8p124rwp
type: GGP
entity:
  breast 25 colorectal 22 and lung 16 cancer 66 patients required a dosage reduction incidence 16 Hematological toxicities were the main cause of reductions 69 The hematological toxicities observed were thrombopenia 35 neutropenia 25 and neutropenia thrombopenia associations 40 The toxicities observed were grade 3 48 or 4 42 The other major causes of reductions were neurological 7 and gastrointestinal 5 The average percentage of reductions was between 15 and 20 The individual interviews have shown that physicians didn t base the dosage reductions on literature results established criteria but on their own clinical practice experience Conclusions 16 of the prescriptions showed a decrease of the regimen Even if there is few literature clinical trials recommend a decrease of 25 of the usual dosage of the drugs The percentage in practice is lower than the one defined by clinical trials The choices of reduction percentage were not standardized Recommendations for dosage reductions are still needed Keywords Dosage reduction Anticancer chemotherapy Toxicity PT 294 Interdisciplinary approach to dose adjustment in patients with renal impairment in secondary care Liekweg A Hinnerkort A Ebeling G Braband S Dreischulte T Heilenkötter K Sander S Schiffmann S Schrimpff U Siems M Wagner K Weiland T Zeigermann G Melzer S Hospital pharmacy of the Asklepios Kliniken Hamburg GmbH Background and Objective As part of a unit


id: cord-015334-8p124rwp
type: GGP
entity:
  Hb increase 1 5 g dL 1 month after the last dose of RTX Results 11 patients 4 men 54 doses RTX average age 65 years range 31 85 Diagnosis AHA 7 2


id: cord-015334-8p124rwp
type: ORG
entity:
  1 Pharmaceutical Sciences Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow


id: cord-015334-8p124rwp
type: WORK_OF_ART
entity:
  Pharmacy 2 Pharmacovigilance 3 Neurology University Hospital Grenoble France Background and Objective


id: cord-015334-8p124rwp
type: ORG
entity:
  The Sector Skills Council for Health Skills for Health Public Health Practice Competences Qualitative


id: cord-015334-8p124rwp
type: DISEASE
entity:
  ischaemic vascular disease cerebrovascular n 27 peripheral vascular n 13 heart failure HF n 12 atrial fibrillation


id: cord-015334-8p124rwp
type: DISEASE
entity:
  pains sore throat headache backache toothache gastrointestinal heartburn diarrhea constipation vomiting hemorrhoids


id: cord-350571-6tapkjb6
type: PROTEIN
entity:
  P2Y 12 receptor inhibitor n 175 97 2 for statin n 174 93 9 for ACEI ARB n 168 and 87 5 for BB n 28 among 32 patients with LVEF 40 Ticagrelor 84 6


id: cord-350571-6tapkjb6
type: GGP
entity:
  Madopar Ò 3 Pravastatin Sandoz Ò 4 Carvedilol Mepha Ò 6 Plavix Ò 6 Pantoprazol Nycomed Ò 7 Adalat Ò CR 7


id: cord-350571-6tapkjb6
type: GGP
entity:
  medicines 11 6 n 31 p 0 001 This group of adolescents better accept the pharmacotherapy with parental supervision 33 2 n 89 p 0 0047


id: cord-350571-6tapkjb6
type: GGP
entity:
  ribavirin 2 5 7 sofosbuvir Simeprevir 4 11 4 sofosbuvir ledipasvir 6 17 1 sofosbuvir ledipasvir ribavirin 3 8 5


id: cord-350571-6tapkjb6
type: TAXON
entity:
  spp Enterococcus spp Pseudomonas aeruginosa Klebsiella spp E coli spp Streptococcus spp Corynebacterium spp


id: cord-350571-6tapkjb6
type: GGP
entity:
  timolol 68 8 brinzolamide 40 6 and latanoprost 37 5 Conclusion We consider of paramount importance the pharmacist evaluation availability at an Orthogeriatric Unit minimizing the impact of acute confusional state during hospital stay by medication reconciliation Please specify your abstract type


id: cord-350571-6tapkjb6
type: ORG
entity:
  Graduate Institute of Clinical Pharmacy 2 School of Pharmacy College of Medicine National Taiwan University


id: cord-350571-6tapkjb6
type: ORG
entity:
  Division of Clinical Pharmacology Service of Biomedicine 4 Institute of Microbiology Lausanne University


id: cord-350571-6tapkjb6
type: CHEMICAL
entity:
  Dobremez 1 Amélie Serra 2 Déborah Grosset Janin 2 Jacqueline Berlioz 1 Aymeric Dopter 3 Jean Henri Ruel 2 1 Pharmacy 2 Neurology Centre Hospitalier Annecy Genevois


id: cord-350571-6tapkjb6
type: DISEASE
entity:
  acute coronary syndromes Sadeer Fhadil Paul Wright Sotiris Antoniou Please specify your abstract type Descriptive abstract for projects Background and objective


id: cord-350571-6tapkjb6
type: CHEMICAL
entity:
  Monzat 1 1 OMEDIT Normandie CHU Rouen 2 CHU Rouen 3 Please specify your abstract type Descriptive abstract for projects Background


id: cord-355038-o2hr5mox
type: CELL_LINE
entity:
  Kais Regaieg Sabrine Nakaa Arnaud Mailloux Madjid Boukari Johana Cohen Dany Goldgran Toledano Groupe hospitalier intercommunal Le Raincy Montfermeil Montfermeil France Correspondence Kais Regaieg


id: cord-355038-o2hr5mox
type: GGP
entity:
  H2 r 0 37 95 CI 0 10 0 59 p 0 0064 We showed a significant relationship between the variation in plasma concentration of GRP78


id: cord-355038-o2hr5mox
type: GGP
entity:
  IV p 10 3 duration of symptoms before hospitalization p 0 03 APACHE II score p 0 04 pH p 0 004 shock on admission p 0 01 and septic shock as evolutionary complication p 0 01 were predictors of mortality in our study Besides shock on admission p 0 001 and as evolutionary complication p 0 017 were the two independent prognostic factors


id: cord-355038-o2hr5mox
type: GGP
entity:
  Agir À Domicile GALICIER Lionel Consultancy Expert NOVARTIS EUSAPHARMA Trainings Teaching Baxalta PFIZER Invitation to national or international congresses No conflict of interest ICHAÏ Philippe No conflict of interest IMEN Sioud No conflict of interest IOOS Vincent No disclosure ISERIN Franck No disclosure ISSA Nahema No conflict of interest JABER Samir Consultancy Expert drager Fisher Paykel Medtronic Baxter Xenios Fresenius Invitation to national or international congresses Drager No conflict of interest JACQ Gwenaëlle No conflict of interest JACQUET Emmanuelle


id: cord-355038-o2hr5mox
type: ORG
entity:
  Réanimation Médicale CHU RENNES Rennes France 3 Réanimation Chirurgicale CHU NANTES Nantes France 4 Réanimation


id: cord-355038-o2hr5mox
type: ORG
entity:
  Fresenius Medical Care Consultancy Expert Fresenius Medical Care Trainings Teaching Fresenius Medical Care Invitation


id: cord-355038-o2hr5mox
type: DISEASE
entity:
  thoracic abdominal neurosurgery gynecologic urologic otorhinolaryngology or spinal surgery The primary


id: cord-007890-bie1veti
type: CELL_LINE
entity:
  Fundación Jiménez Díaz Medical Microbiology Madrid Spain b GlaxoSmithKline Medical Madrid Spain Urine


id: cord-007890-bie1veti
type: CELL_LINE
entity:
  Santa Casa Pediatrics S Paulo Brazil b Santa Casa Microbiology S Paulo Brazil c Adolfo Lutz Microbiology S Paulo Brazil d Adolfo Lutz Bacteriology S Paulo Brazil


id: cord-007890-bie1veti
type: DNA
entity:
  chloramphenicol 9 3 trimethoprim sulfamethoxazole 11 6 tetracycline 4 6 and kanamycin 11 6 Invasive Hi


id: cord-007890-bie1veti
type: CELL_LINE
entity:
  Santa Casa Pediatrics S Paulo Brazil b Elly Lilly Scientific S Paulo Brazil c FAC ABC Pediatrics Santo Andre Brazil d University Hospital Pediatrics S Paulo Brazil A multicenter open label prospective randomized trial in which patients 2 Á 16 years of age with proven GABHS pharyngitis


id: cord-007890-bie1veti
type: DNA
entity:
  Fundación Jiménez Díaz Medical Microbiology Madrid Spain b Fundación Jiménez Díaz Otorrinolaryngology Madrid Spain c GlaxoSmithKline Medical Department Madrid Spain A gerbil model


id: cord-007890-bie1veti
type: DNA
entity:
  AFSSA UMB Ploufragan France b AFSSA HQPAP Ploufragan France c AFSSA LERMVD Fougères France In 1999 620


id: cord-007890-bie1veti
type: PROTEIN
entity:
  V Angelevski A Nikolovski B Military Hospital Microbiology Skopje The Former Yugoslav Republic Macedonia Purpose


id: cord-007890-bie1veti
type: PROTEIN
entity:
  coagulase negative staphylococci 13 Pseudomonas aeruginosa 2 Staphylococcus aureus 1 Acinetobacter baumanii 1 Serratia mercescens 1 Enterobacter cloacae 1 Escherichia coli 1 Proteus mirabilus 1 Enterococcus faecalis 1 Viridans Streptococci 1


id: cord-007890-bie1veti
type: GGP
entity:
  species S pneumoniae Spn S pyogenes Spy S aureus Sau E faecalis Efa M catarrhalis Mca H influenzae Hin E coli Eco K pneumoniae Kpn P mirabilis Pmi and P aeruginosa Pae


id: cord-007890-bie1veti
type: CL
entity:
  Actinobacillus actinomycetemcomitans Eikenella corrodens and Capnocytophaga were 8 16 64 16 16 32 and 8 16 32 mg ml respectively Conclusion Our results show enoxolone has antibacterial effect on A actinomycetemcomitans E corrodens and Capnocytophaga spp Sakalova STN


id: cord-007890-bie1veti
type: GGP
entity:
  penicillin 2 ampicillin 15 amoksicillin clavulonic acid 67 ceftazidime 66 gentamicin 29 tetracycline s 28 erythromycin 61 lincomycin 44 ciprofloksacin 95 cotrimoxazole 82 vancomycin 100 fusidic acid


id: cord-007890-bie1veti
type: GGP
entity:
  mellitus P 0 0 0002 diagnosis of cervical cancer P 0 0 0001 history of pre cancer of vulva Postpartum endometritis due to group A Streptococcus a case control study PM247 Unite Operationnelle d Hygiene All isolates


id: cord-007890-bie1veti
type: WORK_OF_ART
entity:
  DA WHO Centre Collaborating for Prevention and Treatment of Human Echinococcosis University of Franche


id: cord-007890-bie1veti
type: PERCENT
entity:
  3 Schaetz L a Sessa A b a Hoffman La Roche F Basel Switzerland b Italian College of General Practitioners Italy Introduction


id: cord-007890-bie1veti
type: PRODUCT
entity:
  Moretti F Quiros Roldan E Casari S Chiodera A Viale P Carosi G University of Brescia Institute of Infectious and Tropical Diseases Brescia Italy


id: cord-007890-bie1veti
type: WORK_OF_ART
entity:
  Liberti A a Izzo B a Loiacono L b Calabria G a Patarino T a Izzo E a a II Department Naples D Cotugno Hospital Italy


id: cord-007890-bie1veti
type: WORK_OF_ART
entity:
  PS171 Borderon JC a Hamed A b Ragot S b a Centre Hospitalier Universitaire Tours France b Médecine Préventive Universitaire


id: cord-007890-bie1veti
type: ORG
entity:
  a Department of Internal Medicine Derer s University Hospital Bratislava Slovakia b Department of Urology Comenius University School Bratislava Slovakia c Department of Pharmacology St Elisabeth Cancer Institute


id: cord-007890-bie1veti
type: ORG
entity:
  Silan L a Breza J b a Department of Internal Medicine Derer s University Hospital Bratislava Slovakia


id: cord-007890-bie1veti
type: ORG
entity:
  Meropenem Beghi G Aiolfi S Maghini L Patruno V Aiolfi E S Marta Hospital Pulmonary Rehabilitation Unit A O Rivolta


id: cord-007890-bie1veti
type: WORK_OF_ART
entity:
  Hryniewiecki T a Gzyl A b Rawczynska Englert I a a Department of Acquired Valvular Heart Disease National Institute of Cardiology Warsaw Poland b Department of Sera and Vaccines National Institute of Hygiene Warsaw Poland Infective


id: cord-007890-bie1veti
type: FAC
entity:
  PM192 Quintera SM Sousa JC Peixe L Department of Microbiology Faculty of Pharmacy University of Oporto Oporto Portugal


id: cord-007890-bie1veti
type: CHEMICAL
entity:
  Saccharomyces boulardii 2 Enterococcus spp 3 lactulose 4 L casei GG 5 L rhamnosus L bifidus and L acidophilus 6 B


id: cord-007890-bie1veti
type: CHEMICAL
entity:
  penicillin amoxicillin clavulanic acid doxycycline azithromycin clarithromycin ceftriaxone ciprofloxacin levofloxacin moxifloxacin


id: cord-007890-bie1veti
type: CHEMICAL
entity:
  Nuevo Leon Infectologia Monterrey Mexico b Instituto Nacional de Salud Publica Epidemiologia Cuernavaca


id: cord-007890-bie1veti
type: CHEMICAL
entity:
  erythromycin clindamycin vancomycin teicoplanin ciprofloxacin moxifloxacin nourseothricin rifampicin


id: cord-007890-bie1veti
type: CHEMICAL
entity:
  ampicillin azithromycin ciprofloxacin cefepime cefuroxime cefotaxime ceftazidime ceftriaxone cefoxitin chloramphenicol cotrimoxazole


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  H1 A M Polyanichko 1 H Wieser 2 1 Faculty of Physics Saint Petersburg State University Russia 2 Dept


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  antitumor nonclassical platinum complexes O Vrana V Kohoutkova V Brabec Institute of Biophysics AS CR Královopolská 135 CZ 61265


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  CYP450 L S Goto 2 C O Hokka 1 J F Lima 2 O R Nascimento 2 A P U Araújo 2 1 Grupo de Engenharia Bioquímica UFSCar BR 2


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  Complex I A L Maniero 1 C Bergamini 2 M Bortolus 1 R Fato 2 S Leoni 2 G Lenaz 2 1 Università degli Studi di Padova Padova Italy 2 Università degli studi di Bologna Bologna Italy Complex I NADH Dehydrogenase


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  arXiv 0805 0696v1 S Soria 1 F Quercioli 3 R Mercatelli 3 F Bianco 2 I Cacciari 2 G Righini 2 1 Centro Studi e Ricerche E Fermi P Del Viminale 2 00184 Rome Italy 2


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  plague F1 capsular antigen A Soliakov 1 J R Harris 1 M R Hicks 2 A Rodger 2 R Woody 3 A Watkinson 4 J H Lakey 1 1 Cell


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  membrane proteins C V Kulkarni 3 O Ces 1 S Iwata 2 R H Templer 1 1 Chemical Biology Centre and Department of Chemistry Imperial College London United Kingdom 2 Division of Molecular


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  lambda bacteriophage epigenetic switch L Finzi Physics Department emory University 400 dowman Dr Atlanta GA 30322 USA


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  topoisomerase II activity H Seidel 1 T Klose 2 H Lilie 2 C G Hübner 1 1 Institute of Physics Ratzeburger Allee 160 23538 Lübeck Germany 2 Institute of Biochemistry and Biotechnology Kurt Mothes Str 3 06120 Halle Germany One essential element


id: cord-004534-jqm1hxps
type: DNA
entity:
  human MEF2D gene W Zhou 1 L Ying 2 1 Molecular Medicine National Heart and Lung Institute Imperial College London London SW7 2AZ UK 2 Chemical Biology


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  OmpF channel E Hajjar 1 A Kumar 1 M Winterhalter 2 P Ruggerone 1 M Ceccarelli 1 1 Department of Physics University of Cagliari Italy 2


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  protein N Maghelli 1 V Krstic 2 N Pavin 2 F Julicher 2 I Tolic Norrelykke 1 1 MPI CBG Dresden Germany 2 MPI PKS Dresden Germany


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  integrin αIIbβ3 M Rocco 1 C Rosano 1 J W Weisel 2 D Horita 3 R R Hantgan 3 1 Istituto Nazionale per la Ricerca sul Cancro IST Genova Italy 2


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  redox cofactor L Erokhova 1 P Kügler 2 P Pohl 1 1 Institute of Biophysics Johannes Kepler University Linz Austria 2


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  cation channels Y Sawada 1 M Murase 2 M Sokabe 1 1 Dept Physiol Nagoya Univ Grad Sch Med Nagoya Japan 2


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  Na K ATPase C H Chang 1 T Y Tsong 2 1 Institute of Physics National Chiao Tung university Physics Division National Center for Theoretical Sciences Hsinchu Taiwan 2 Institute of Physics Academy of Sciences Taipei 115 Taiwan Na K ATPase


id: cord-004534-jqm1hxps
type: CELL_TYPE
entity:
  permeabilized skeletal muscle fibres D S Ushakov D Ibanez Garcia T G West P M W French M A Ferenczi Imperial College London UK


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  extracellular matrix molecule hyaluronic acid modulates L type voltage dependent Ca2 channels E Dvoretskova 1 G Kochlamazashvili 2 O Bukalo 2 C Henneberger 3 D Rusakov 3 M Schachner 2 A Dityatev 1 1 Italian Institute of Technology Genova Italy 2


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  colicin translocon C L Johnson 1 A Solovyova 1 P Callow 2 S A Holt 3 L A Clifton 3 K Weiss 4 J H Lakey 1 1


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  human 3 phosphoglycerate kinase P Lallemand 1 J Rouhana 1 L Chaloin 1 B Roy 2 S Arold 3 T Barman 1 C Lionne 1 1 CPBS UMR 5236 4 bd Henri IV


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  Green Fluorescent Protein G Jung Biophysical Chemistry Saarland University 66123 Saarbruecken Germany Biotechnological design of the Green Fluorescent Protein GFP


id: cord-004534-jqm1hxps
type: PROTEIN
entity:
  J Strömqvist 1 S Johansson 1 Y Ohsugi 3 K Andersson 2 L Xu 1 M Kinjo 3 P Höglund 2 J Widengren 1 1 Experimental biomolecular Physics KTH Stockholm Sweden 2


id: cord-004534-jqm1hxps
type: GGP
entity:
  Alzheimer s disease Some diabetes drugs appear to decrease the cognitive decline associated with Alzheimer s


id: cord-004534-jqm1hxps
type: GGP
entity:
  human 3 phosphoglycerate kinase P Lallemand 1 J Rouhana 1 L Chaloin 1 B Roy 2 S Arold 3 T Barman 1 C Lionne 1 1


id: cord-004534-jqm1hxps
type: ORG
entity:
  Institute for Problems of Cryobiology and Cryomedicine National Academy of Sciences of Ukraine Kharkov Ukraine


id: cord-004534-jqm1hxps
type: ORG
entity:
  Physics Department University of Genoa Italy 2 Biochemical Sciences Department University of Florence Italy Short


id: cord-004534-jqm1hxps
type: ORG
entity:
  Molski Adam Mickiewicz University Laboratory for Dynamics of Physicochemical Processes Poznan Poland RNAzymes


id: cord-004534-jqm1hxps
type: ORG
entity:
  Department of Physics Faculty of Science Messina University Italy 2 Department of Physics Faculty of Science Perugia University Italy Important


id: cord-004534-jqm1hxps
type: ORG
entity:
  Chemistry University of Oxford Oxford U K 2 Department of Electronics Computer Science and Systems University of Bologna Bologna Italy Potassium


id: cord-004534-jqm1hxps
type: ORG
entity:
  Institute of Physics National Chiao Tung university Physics Division National Center for Theoretical Sciences Hsinchu


id: cord-004534-jqm1hxps
type: ORG
entity:
  Department of Physics University of Warwick U K 2 Department of Chemistry University of Warwick U K Information


id: cord-004534-jqm1hxps
type: ORG
entity:
  Biotechnology Jagiellonian University 2 Department of Pharmacodynamics Medical College Jagiellonian University


id: cord-004534-jqm1hxps
type: LAW
entity:
  A Isvoran 1 E Quiniou 2 C Craescu 2 L Mouawad 2 1 West University of Timisoara Department of Chemistry Pestalozzi


id: cord-004534-jqm1hxps
type: WORK_OF_ART
entity:
  A Martino D Crane I M Feavers B Bolgiano Division of Bacteriology National Institute for Biological Standards and Control Potters


id: cord-004534-jqm1hxps
type: CHEMICAL
entity:
  E Del Favero 1 G Di Fede 2 F Tagliavini 2 M Salmona 3 L Cantù 1 1 University of Milan Segrate Italy 2 Carlo


id: cord-004534-jqm1hxps
type: CHEMICAL
entity:
  L D Alfonso 1 M Collini 1 M Caccia 1 G Tallarida 2 S Caprioli 2 G Chirico 1 1 Dipartimento di Fisica Università di Milano Bicocca Italy 2 Laboratorio


id: cord-004534-jqm1hxps
type: CHEMICAL
entity:
  1 D Magatti 1 B Cardinali 2 A Profumo 2 M Rocco 2 1 Dipartimento di Fisica e Matematica Università dell Insubria


id: cord-023049-fio7cjj5
type: PROTEIN
entity:
  mutant protein Boutahar N 1 Reynaud E 1 Nasser Y 1 Camdessanché JP 1 Antoine JC 1 1 University Hospital Saint Etienne France Dysimmune sensory neuronopathies


id: cord-023049-fio7cjj5
type: CELL_LINE
entity:
  NIH Rare Diseases Clinical Research Network grant 1U54NS065712 01 Feely SME 1 Saade D 1 Shy ME 1 1 Carver College of Medicine University of Iowa Iowa City IA USA


id: cord-023049-fio7cjj5
type: CELL_LINE
entity:
  NIH Rare Diseases Clinical Research Network grant 1U54NS065712 01 Fisgun A 1 Luan X 1 Hoke A 1 1 Johns Hopkins University Baltimore MD USA Molecular mechanisms that underlie slow distal axonal degeneration seen in chemotherapy induced peripheral neuropathy CIPN are unclear However several identified molecular targets


id: cord-023049-fio7cjj5
type: CELL_LINE
entity:
  MMN Krarup C 1 2 Moldovan M 1 2 Alvarez S 1 Ciano C 3 Pisciotta C 3 Pareyson D 3 1 University of Copenhagen Copenhagen Denmark 2 Rigshospitalet Copenhagen Denmark 3 Fondazione IRCCS Istituto Neurologico C Besta INCB Milan Italy Mutations


id: cord-023049-fio7cjj5
type: PROTEIN
entity:
  RDCRN INC Contact Registry Martinez C 1 Hubsch A 2 Watson DJ 3 Shebl A 4 Wallenhorst C 1 Simon TL 3 1 Institute


id: cord-023049-fio7cjj5
type: PROTEIN
entity:
  CMT Painous C 1 López Pérez MA 2 Illa I 1 3 Querol L 1 3 1 Neuromuscular Diseases Unit Neurology Department Hospital de la Santa Creu


id: cord-023049-fio7cjj5
type: DNA
entity:
  MPZ missense mutations Poitras T 1 Chandrasekhar A 1 Singh V 1 Martinez J 1 Zochodne DW 1 1 Neuroscience Mental Health Institute and Division


id: cord-023049-fio7cjj5
type: PROTEIN
entity:
  Antinuclear Antibody 1 1280 reference 1 40 SS A 148 reference 20 U SS B 79 reference 20 U and Rheumatoid Factor 24 reference 14 IU mL titers


id: cord-023049-fio7cjj5
type: CELL_LINE
entity:
  São Paulo Ribeirão Preto Brazil 2 Neurogenetics Department of Neurosciences and Behaviour Sciences University of São Paulo Ribeirão Preto Brazil


id: cord-023049-fio7cjj5
type: DNA
entity:
  Topa A 1 Spina E 1 Iodice R 1 Tozza S 1 Ruggiero L 1 Dubbioso R 1 Esposito M 1 Santoro L 1 Manganelli F 1 1 University of Naples Federico II Naples Italy


id: cord-023049-fio7cjj5
type: CELL_LINE
entity:
  Paediatric CMT Best Practice Guidelines Consortium 1 Royal Children s Hospital Melbourne Melbourne Victoria Australia 2 Murdoch Childrens Research Institute Melbourne Victoria Australia 3 University of Melbourne Melbourne Victoria Australia 4 University of Sydney New South Wales Australia 5 Sydney Children s Hospitals Network Randwick and Westmead New South Wales Australia Charcot Marie Tooth disease CMT


id: cord-023049-fio7cjj5
type: GGP
entity:
  Kagiava A 1 Karaiskos C 1 Richter J 2 Tryfonos C 2 Lapathitis G 1 Sargiannidou I 1 Christodoulou C 2


id: cord-023049-fio7cjj5
type: ORG
entity:
  Spain 3 Department of Cell Biology Physiology and Immunology Institute of Neurosciences Universitat Autònoma de Barcelona


id: cord-023049-fio7cjj5
type: ORG
entity:
  Department of Neurology Reference Center for Rare Peripheral Neuropathies University Hospital of Limoges Limoges France Prolonged


id: cord-023049-fio7cjj5
type: FAC
entity:
  1 Hilmarsen HT 1 Svendsen M 1 Høyer H 1 1 Section of Medical Genetics Department of Laboratory Medicine Telemark Hospital


id: cord-023049-fio7cjj5
type: ORG
entity:
  Department of Neurology University of Iowa Carver College of Medicine Iowa City IA USA 3 Department of Neurogenetics


id: cord-023049-fio7cjj5
type: ORG
entity:
  University of Colorado Hospital Aurora CO USA 2 University of Iowa Hospitals and Clinics Iowa City IA USA


id: cord-023049-fio7cjj5
type: ORG
entity:
  Massachusetts General Hospital Boston MA USA 2 University of Massachusetts Medical School Worcester USA 3 University Hospital


id: cord-023049-fio7cjj5
type: ORG
entity:
  Department of Rehabilitation and Medicine University of Occupational and Environmental Health Kitakyushu Japan 3 Division of Plastic


id: cord-023049-fio7cjj5
type: ORG
entity:
  Hayes JM 1 O Brien PD 1 Backus C 1 Feldman EL 1 1 Department of Neurology University of Michigan Ann Arbor


id: cord-023049-fio7cjj5
type: ORG
entity:
  National Neuroscience Institute Singapore Singapore 2 Lee Kong Chian School of Medicine Nanyang Technological University


id: cord-023049-fio7cjj5
type: ORG
entity:
  Yong Loo Lin School of Medicine National University Singapore Singapore 4 Tan Tock Seng Hospital Singapore


id: cord-023049-fio7cjj5
type: ORG
entity:
  Perelman School of Medicine University of Pennsylvania Philadelphia PA USA 2 Columbia University School of Medicine New York NY USA Heterozygous


id: cord-023049-fio7cjj5
type: ORG
entity:
  Department of Neurology National Referral Center for Rare Neuromuscular Diseases Pitié Salpêtrière Hospital


id: cord-023049-fio7cjj5
type: ORG
entity:
  The Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences


id: cord-023049-fio7cjj5
type: ORG
entity:
  Department of Neurology University of Michigan Ann Arbor USA 2 Department of Internal Medicine Division on Metabolism Endocrinology and Diabetes University of Michigan


id: cord-023049-fio7cjj5
type: ORG
entity:
  Neurology Clinics Cyprus Institute of Neurology and Genetics and Cyprus School of Molecular Medicine


id: cord-023049-fio7cjj5
type: ORG
entity:
  Hunter James Kelly Research Institute University at Buffalo Buffalo USA 5 Department of Biochemistry University at Buffalo Buffalo USA 6 Neurology Jacobs School of Medicine and Biomedical Sciences University


id: cord-023049-fio7cjj5
type: ORG
entity:
  the Netherlands 2 Academic Medical Center University of Amsterdam Department of Clinical Rheumatology and Immunology Amsterdam


id: cord-023049-fio7cjj5
type: ORG
entity:
  Neuroscience University of Padua Padua Italy 2 Hematology and Clinical Immunology Unit Department of Medicine University of Padua Padua Italy 3


id: cord-023049-fio7cjj5
type: ORG
entity:
  Mount Sinai Medical Center Beth Israel Deaconess Medical Center Northwestern University Medical Center University of Utah Medical Center


id: cord-023049-fio7cjj5
type: CHEMICAL
entity:
  Alonso Jiménez A 1 2 Belvis Nieto R 3 Diaz Manera J 1 2 Illa I 1 2 Querol L 1 2 1 Neuromuscular Diseases


id: cord-023049-fio7cjj5
type: CHEMICAL
entity:
  El Soury M 1 Muratori L 1 2 Tos P 4 Battiston B 3 Geuna S 1 2 Gambarotta G 1 1 Department of Clinical and Biological Sciences University of Turin Italy


id: cord-023049-fio7cjj5
type: CHEMICAL
entity:
  Gundapaneni B 1 Sultan MB 2 Keohane DJ 2 Schwartz J 2 1 inVentiv Health Inc Burlington MA USA 2 Pfizer Inc New York NY USA Transthyretin


id: cord-023049-fio7cjj5
type: DISEASE
entity:
  peripheral nerve sheath tumors Jacobsen B 1 Parry G 2 Allen J 2 Walk D 2 Muley S 1 Ortega E 1 1 Barrow Neurological Institute Phoenix AZ


id: cord-023049-fio7cjj5
type: CHEMICAL
entity:
  Moschella F 3 Geuna S 1 2 Raimondo S 1 2 1 Department of Clinical and Biological Sciences University of Turin Orbassano TO Italy 2 Neuroscience Institute of the Cavalieri Ottolenghi Foundation


id: cord-023049-fio7cjj5
type: CHEMICAL
entity:
  D 1 Stojkovic T 2 Leonard Louis S 2 Reilly MM 3 Laurà M 3 Parman Y 4 Battaloglu E 4 Tazir M 5 Bellatache M 5 Bonello Palot N 6 Sacconi S 7 Guimarães Costa R 2 Attarian S 6 Latour P 8 Megarbane A 2 Schenone A 9 Ursino G 9 Sabatelli M 10 Luigetti


id: cord-023049-fio7cjj5
type: CHEMICAL
entity:
  Psimaras D 3 Kuntzer T 4 Taieb G 5 Créange A 6 Delmont E 7 Camdessanché JP 1 Antoine JC 1 1 University


id: cord-023049-fio7cjj5
type: CHEMICAL
entity:
  Kovalova E 1 2 Nekvapilova E 1 2 Belobradkova J 6 Olsovsky J 7 Weber P 8 Dusek L 9 Jarkovsky J 9 Bednarik J 1 2 Despite


# bib

id: cord-000425-isw6jeir
title: Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation
author: Flori, Laurence
date: 2011-07-29
txt: ./txt/cord-000425-isw6jeir.txt
cache: ./cache/cord-000425-isw6jeir.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146468/
doi: 10.1371/journal.pone.0022717
summary:
  A study on Yorkshire pigs selected for eight generations for high and low adaptive IR (HIR and LIR, respectively) on an index combining four standardized measures of specific antibodies and cellmediated IR, after stimulation with specific antigens (bacillus Calmette-Guérin and hen egg white lysozyme), has revealed that HIR and LIR animals differ in response to immunization and infection [2, 11, 12, 13, 14] . Finally, several significant QTLs for total leukocyte count ( [20, 21] ; Animal-QTLdb, http://www.animalgenome.org/cgi-bin/QTLdb/index), mitogen-induced proliferation [20] , antibody response [20, 22] , cytokine production (IL10 and IFNc) [23] , complement activity [22] , and acute phase protein serum concentration [22] have been detected and mapped to different pig chromosomes. In this report, we present the results of a global genetic study, combining principal component analysis (PCA), and genetic parameter estimation applied to a large number of innate and adaptive ITs in a pig population vaccinated against Mycoplasma hyopneumoniae (M.

abstract:
  BACKGROUND: Increasing robustness via improvement of resistance to pathogens is a major selection objective in livestock breeding. As resistance traits are difficult or impossible to measure directly, potential indirect criteria are measures of immune traits (ITs). Our underlying hypothesis is that levels of ITs with no focus on specific pathogens define an individual's immunocompetence and thus predict response to pathogens in general. Since variation in ITs depends on genetic, environmental and probably epigenetic factors, our aim was to estimate the relative importance of genetics. In this report, we present a large genetic survey of innate and adaptive ITs in pig families bred in the same environment. METHODOLOGY/PRINCIPAL FINDINGS: Fifty four ITs were studied on 443 Large White pigs vaccinated against Mycoplasma hyopneumoniae and analyzed by combining a principal component analysis (PCA) and genetic parameter estimation. ITs include specific and non specific antibodies, seric inflammatory proteins, cell subsets by hemogram and flow cytometry, ex vivo production of cytokines (IFNα, TNFα, IL6, IL8, IL12, IFNγ, IL2, IL4, IL10), phagocytosis and lymphocyte proliferation. While six ITs had heritabilities that were weak or not significantly different from zero, 18 and 30 ITs had moderate (0.1<h2≤0.4) or high (h2>0.4) heritability values, respectively. Phenotypic and genetic correlations between ITs were weak except for a few traits that mostly include cell subsets. PCA revealed no cluster of innate or adaptive ITs. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that variation in many innate and adaptive ITs is genetically controlled in swine, as already reported for a smaller number of traits by other laboratories. A limited redundancy of the traits was also observed confirming the high degree of complementarity between innate and adaptive ITs. Our data provide a genetic framework for choosing ITs to be included as selection criteria in multitrait selection programmes that aim to improve both production and health traits.


id: cord-004534-jqm1hxps
title: Abstract
author: nan
date: 2009-06-09
txt: ./txt/cord-004534-jqm1hxps.txt
cache: ./cache/cord-004534-jqm1hxps.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079852/
doi: 10.1007/s00249-009-0478-1
abstract: nan
summary:
  HIV-1 to efficiently complete a replication cycle has to integrate its genome into the host cellular DNA.After HIV-1 enters target cells,neosynthesized viral DNA forms along with other proteins the pre-integration complex (PIC).PICs are then transported into the nucleus where integration,catalyzed by the viral integrase,takes place.HIV-1 viral particles engineered to incorporate integrase fused to EGFP have proven effective to study PICs within nuclei of infected cells.In this study we report the live imaging analysis of nuclear PIC dynamics obtained by time-lapse microscopy.Intranuclear trajectories of IN-EGFP-labeled PIC were collected in three dimensions and examined by both mean squared displacement (MSD) and cage diameter (CD) analysis.In CD the maximum distances measured between two positions occupied by a PIC in a time window of 2 minutes were calculated while in our MSD analysis 5-minute long trajectory segments were considered.Remarkably,MSD revealed the presence of an underlying active transport mechanism.To test the possible role of actin filaments,PIC nuclear trafficking was analyzed in cells treated with latrunculin B (actin polymerization inhibitor).Preliminary results suggest that the disruption of actin function impairs the active nuclear movement of PICs. Second harmonic generation microscopy reveals sarcomere contractile dynamics of cardiomyocytes N.


id: cord-007890-bie1veti
title: ECC-4 Abstracts
author: nan
date: 2002-04-16
txt: ./txt/cord-007890-bie1veti.txt
cache: ./cache/cord-007890-bie1veti.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126403/
doi: 10.1016/s0924-8579(02)00033-x
abstract: nan
summary:
  Effects of Interferon alpha plus ribavirine therapy on frequencies of HCV, HIV and CMV specific CD4-T-cell responses in peripheral blood of HIV/HCV coinfected patients after 6 months of treatment SoA9.5 Methods: Two groups of patients with chronic HCV infection were studied: 26 HIV coinfected progressors with antiretroviral therapy and 13 HIV-negative controls. In order to assess the local temporal trend of antibiotic sensitivity of the most common urinary tract bacterial pathogen, all urine-cultured Escherichia coli isolates were reviewed as to susceptibility profile, and specimen source (community-versus hospital-acquired infection). Methods: A total of 87 penicillin resistant clinical strains isolated from patients at Hacettepe Children''s Hospital, Ankara, Turkey between 1999 and 2001 were tested for their in vitro susceptibility to various antibiotics that are commonly used in the treatment of respiratory tract infections.


id: cord-014538-6a2pviol
title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress
author: Kamilia, Chtara
date: 2017-01-10
txt: ./txt/cord-014538-6a2pviol.txt
cache: ./cache/cord-014538-6a2pviol.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225389/
doi: 10.1186/s13613-016-0224-7
abstract: nan
summary:
  Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality).


id: cord-014685-ihh30q6f
title: Posters P788 - P999
author: nan
date: 2005-09-21
txt: ./txt/cord-014685-ihh30q6f.txt
cache: ./cache/cord-014685-ihh30q6f.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080055/
doi: 10.1007/s00249-005-0504-x
abstract: nan
summary:
  This study has attempted to analyse the structural properties of membrane peptides and proteins through the use of model systems that have been designed to mimic their natural counterparts: Podlubnaya 2 1 Institute of Theoretical and Experimental Biophysics RAS, 2 Pushchino State University Amyloid brils are formed by proteins or their peptides in the result of a conformational transition from alpha helix into beta-sheet structure. Analysis of the results of such studies indicate that folding of SNase fragments is dominated by developing the local and non-local nucleation sites from native-like secondary structures and by intensifying the longrange interactions of residues at nucleation sites with residues further removed in sequence. The results show that at different pH values the aggregation processes of both proteins follow different pathways determined by the variations in the native structure and by the details of the involved conformational changes.


id: cord-015334-8p124rwp
author: nan
date: 2008-06-11
txt: ./txt/cord-015334-8p124rwp.txt
cache: ./cache/cord-015334-8p124rwp.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102062/
doi: 10.1007/s11096-008-9226-3
abstract: nan
summary:
  Based on the results of the pharmacoeconomic analysis, development of clinical pharmacy and CIVAS for some drugs will be discussed with the paediatric department Background and Objective: Studies show that up to 38% of patients starting treatment with antidepressants fill only a single prescription at the pharmacy, apparently not accepting treatment. Main Outcome Measures: Data collected were: nurses'' profile (age, length of service, competencies'' self-assessment), knowledge on drugs prescribed to their patients (usage, administration, side-effects, drug interactions…), use of existing tools (i.e. drugs database) and possible tools to be developed by the pharmacy ward to help them in their daily practice. The objectives were:(1)To identify the most relevant minor ailments, agreeing on the specific criteria for referral to the GP.(2)To select the non-prescription drugs, with evidence of safety and effectiveness, for the treatment of the identified minor ailments Design: Qualitative study with an expert panel which was made up of 2 primary care physician from SEMFYC and six community pharmacists (two members of SEFAC and four members of GIAF-UGR).

title:
  ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts


id: cord-016095-jop2rx61
title: Challenges for Experimentation on Living Beings at the Dawn of the 21(st) Century
author: Vignais, Pierre V.
date: 2010-06-08
txt: ./txt/cord-016095-jop2rx61.txt
cache: ./cache/cord-016095-jop2rx61.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120277/
doi: 10.1007/978-90-481-3767-1_5
summary:
  Instead of setting out to discover unknown mechanisms by analyzing effects that are dependent on specific causes, with some uncertainty as to the possible success of the enterprise being undertaken, which is the foundation stone of the Bernardian paradigm of the experimental method, many current research projects give themselves achievable and programmable objectives that depend upon the means available to them: sequencing of genomes with a view to comparing them, recognition of sequence similarities in proteins coded for by genes belonging to different species, with the aim of putting together phylogenetic trees, synthesis of interesting proteins in transgenic animals and plants, analysis of the three-dimensional structure of proteins, in order to find sites that are likely to fix medicinal substances, and synthesis of molecular species able to recognize pathogenic targets.

abstract:
  “We can talk endlessly about moral progress, about social progress, about poetic progress, about progress made in happiness; nevertheless, there is a type of progress that defies any discussion, and that is scientific progress, as soon as we judge it within the hierarchy of knowledge, from a specifically intellectual point of view.”


id: cord-021158-075vh5jg
author: Fortané, Nicolas
date: 2020-01-06
txt: ./txt/cord-021158-075vh5jg.txt
cache: ./cache/cord-021158-075vh5jg.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149086/
doi: 10.1007/s41130-019-00098-4
summary:
  Using recent debates on the AMR problem, it proposes to examine the relationship between the development of professional veterinary expertise and of the drug market, based on the case of a specific segment of the profession, namely veterinarians specializing in industrial poultry and pig production in western France. Indeed, it is common to hear professional organizations or public authorities state that in order to reduce their economic dependence on antibiotic sales, vets must rethink their activity by favouring preventive approaches to animal health which would involve a diversified range of services and would contribute to placing vets in an advisory role with a holistic vision of livestock farming or even of the food supply chain (VetFuturs France 2018) .

title:
  Antimicrobial resistance: preventive approaches to the rescue? Professional expertise and business model of French “industrial” veterinarians

abstract:
  This article focuses on the development of veterinary medicine in the industrial pig and poultry production sector. In the current context of controversies over the public problem of antimicrobial resistance (AMR), the veterinary profession is tending to promote a model of preventive medicine that is supposed to reduce the use of antibiotics in livestock farming. However, veterinarians specializing in pig and poultry production (“industrial vets”) have in fact been adopting such approaches to animal health for several decades. Based on 28 interviews with pig and poultry veterinarians practicing or having practiced in western France between the 1970s and the 2010s, the article aims to understand how such a form of professional expertise has developed, and the business model that underpins it. Contrary to public discourses which promote preventive approaches as a way to diversify professional expertise and to disconnect veterinary incomes from drug sales, it is indeed this economic model that has allowed the development of such approaches within industrial livestock farming. Modern strategies for reducing antibiotic use should therefore seek less to renew the professional expertise of veterinarians than to find new ways to valorize it economically.


id: cord-023049-fio7cjj5
title: 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain
author: nan
date: 2017-06-22
txt: ./txt/cord-023049-fio7cjj5.txt
cache: ./cache/cord-023049-fio7cjj5.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166380/
doi: 10.1111/jns.12225
abstract: nan
summary:
  Clinical efficacy (Medical Research Council sum score, 10-m walk, modified Inflammatory Neuropathy Cause and Treatment score, Overall Neuropathy Limitations Scale, Romberg test) and patient-reported outcomes (36-item Short Form Health Survey , Life Quality Index [LQI] ) were assessed at baseline and at regular intervals until the final visit (10-14 months after switching). To explore the issue of early biomarkers in FAP, we performed skin biopsy and compared IENF density with parameters of nerve conduction studies (NCS) and quantitative sensory testing (QST) on 36 subjects (23 men, aged 55.1 ± 11.1 years) with genetic confirmation of TTR-A97S: 17 patients and 19 carriers. Results: The Gly112Ser mutation causing CMT1C is a mild form of CMT, as patients walked on time, had less weakness than those with Charcot-Marie-Tooth Disease type 1A (CMT1A), had a Charcot Marie Tooth neuropathy score (CMTNS) indicative of mild disease, and had faster ulnar and median motor nerve conduction velocities compared to those with CMT1A.


id: cord-252950-eiphxwmn
title: Type I IFN immunoprofiling in COVID-19 patients
author: Trouillet-Assant, Sophie
date: 2020-04-29
txt: ./txt/cord-252950-eiphxwmn.txt
cache: ./cache/cord-252950-eiphxwmn.txt
extension: .txt
mime: text/plain
url: https://doi.org/10.1016/j.jaci.2020.04.029
doi: 10.1016/j.jaci.2020.04.029
summary:
  COVID patients in ICU present a high mortality rate and immunoprofiling reveals heterogeneous IFN-α2 production with about 20% of critically-ill patients unable to produce IFN-α2, highlighting the immune response heterogeneity and opening avenues for targeted therapies. 42 Capsule summary: 43 COVID patients in ICU present a high mortality rate and immunoprofiling reveals heterogeneous α2 production with about 20% of critically-ill patients unable to produce IFN-α2, highlighting the 45 immune response heterogeneity and opening avenues for targeted therapies. Various immunosuppressive drugs, including IL-6 blockers or JAK-STAT signaling inhibitors have been 56 suggested for the treatment of SARS-COV-2 infection 2 whereas additional clinical trials are evaluating 57 the use of recombinant interferon to foster host antiviral response. To date, IFN-I response has not been evaluated in COVID-19 60 patients and its contribution to the viral control and inflammation is unknown. We further explored a larger cohort of 26 critically ill COVID patients from one of the intensive care 75 unit (ICU) at Hospices Civils de Lyon (Lyon, France).

abstract:
  COVID patients in ICU present a high mortality rate and immunoprofiling reveals heterogeneous IFN-α2 production with about 20% of critically-ill patients unable to produce IFN-α2, highlighting the immune response heterogeneity and opening avenues for targeted therapies.


id: cord-253801-y1nherse
author: Lepelletier, Didier
date: 2009-11-30
txt: ./txt/cord-253801-y1nherse.txt
cache: ./cache/cord-253801-y1nherse.txt
extension: .txt
mime: text/plain
url: https://api.elsevier.com/content/article/pii/S0001407919324161
doi: 10.1016/s0001-4079(19)32416-1
summary:
  title: Risque d''introduction et voies d''importation par l''homme de maladies infectieuses exotiques : cas particulier de l''émergence de bactéries pathogènes multirésistantes aux antibiotiques, importées en France à l''occasion de voyages internationaux ou du rapatriement de patients hospitalisés à l''étranger Le rapatriement sanitaire de français hospitalisés à l''étranger, mais aussi les simples retours de voyage et la prise en charge sanitaire d''étrangers en voyage en France, quelle que soit leur nationalité, expose donc la population française à des bactéries multirésistantes aux antibiotiques qui auraient pu être acquises dans des zones de haute prévalence de résistance. On sait toutefois qu''il est réel et des évènements sporadiques ou épidémiques ont été observés concernant des pathogènes tels que Mycobacterium tuberculosis multirésistant, Clostridium difficile de ribotype 027, Klebsiella pneumoniae productrice de carbapénèmase, Acinetobacter baumannii multirésistant, Staphylococcus aureus résistant à la méticilline commu-Bull.

title:
  Risque d’introduction et voies d’importation par l’homme de maladies infectieuses exotiques : cas particulier de l’émergence de bactéries pathogènes multirésistantes aux antibiotiques, importées en France à l’occasion de voyages internationaux ou du rapatriement de patients hospitalisés à l’étranger

abstract:
  SUMMARY The spread of multidrug-resistant bacteria has become a major problem in France in recent years, owing to increasing antibiotic exposure, growing international exchanges, repatriation of hospitalized French patients, and treatment of French and foreign travelers in French hospitals. This article examines how different pathogens may become endemic in France.


id: cord-257325-pvf0uon3
author: Zeitoun, Jean-David
date: 2020-10-10
txt: ./txt/cord-257325-pvf0uon3.txt
cache: ./cache/cord-257325-pvf0uon3.txt
extension: .txt
mime: text/plain
url: https://www.sciencedirect.com/science/article/pii/S0033350620304340?v=s5
doi: 10.1016/j.puhe.2020.09.015
summary:
  Objectives We aimed to investigate possible differences in aggregated hospital-fatality rate from COVID-19 in France at the early phase of the outbreak, and to determine whether factors related to population or healthcare supply before the pandemic could be associated with outcome differences. After multivariable analysis, four factors were independently associated with a significantly higher aggregated hospital-fatality rate: a higher ICU capacity at baseline (estimate=1.47; p=0.00791), a lower density of general practitioners (estimate=0.95; p=0.0205), a higher fraction of activity from the for-profit private sector (estimate=0.99; p<0.001), and the ratio of people over 75 (estimate=0.91; p=0.0023). Apart from the population, four factors were independently associated with a significantly higher aggregated hospital-fatality rate from Covid-19: a higher ICU capacity at baseline (estimate=1.47; p=0.00791), a lower density of general practitioners (estimate=0.95; p=0.0205), a higher fraction of activity from the for-profit private sector (estimate=0.99; p<0.001) and the ratio of people over 75 (estimate=0.91; p=0.0023).

title:
  Impact of Local Care Environment and Social Characteristics on Aggregated Hospital-Fatality Rate from COVID-19 in France: Nationwide Observational Study

abstract:
  Objectives We aimed to investigate possible differences in aggregated hospital-fatality rate from COVID-19 in France at the early phase of the outbreak, and to determine whether factors related to population or healthcare supply before the pandemic could be associated with outcome differences. Study design Nationwide observational study including all French hospitals from January 24, 2020 to April 11, 2020. Methods We analysed aggregated hospital-fatality rate. A Poisson regression was performed to investigate associations between characteristics pertaining to populational health, socioeconomic context and local healthcare supply at baseline, and the chosen outcome. Results On April 11, 2020, a total number of 30 960 patients were hospitalized among the 3 046 French healthcare facilities, including 6 832 patients in intensive care unit (ICU). A total of 8 581 deaths due to Covid-19 had been recorded, with a median mortality rate per 10 000 people per department of 0.53 (IQR: 0.29-1.90). There were significant variations between the 95 French departments even after adjusting on outbreak inception (p<0.001). After multivariable analysis, four factors were independently associated with a significantly higher aggregated hospital-fatality rate: a higher ICU capacity at baseline (estimate=1.47; p=0.00791), a lower density of general practitioners (estimate=0.95; p=0.0205), a higher fraction of activity from the for-profit private sector (estimate=0.99; p<0.001), and the ratio of people over 75 (estimate=0.91; p=0.0023). Conclusions Aggregated hospital-fatality rate from COVID-19 in France seems to vary among geographic areas, with some factors pertaining to local healthcare supply being associated with outcome.


id: cord-262046-bb8ekgdm
title: Epidemic analysis of COVID-19 Outbreak and Counter-Measures in France
author: Unlu, E.
date: 2020-05-01
txt: ./txt/cord-262046-bb8ekgdm.txt
cache: ./cache/cord-262046-bb8ekgdm.txt
extension: .txt
mime: text/plain
url: https://doi.org/10.1101/2020.04.27.20079962
doi: 10.1101/2020.04.27.20079962
summary:
  We propose to use a variant of the well known SEIR model to analyze the spread of COVID-19 in France, by taking in to account the national lockdown declared in March 11, 2020. As number of confirmed cases shall not be fully representative due to low testing especially in the first phases of the outbreak, we present that basing the model optimisation on the fatalities can provide legitimate results. Note that, with this approach the initial state values are also defined in terms of proportion of fatalities, hence they also are parameters of the PSO optimization. Using the developed model we predict that if lockdown continues with strict measures, the total number of COVID-19 fatalities should topple below 50,000 (which is currently around 20,000) by late August, 2020; where the effects of the epidemic start to significantly diminish.

abstract:
  COVID-19 pandemic has triggered world-wide attention among data scientists and epidemiologists to analyze and predict the outcomes, by using previous statistical epidemic models. We propose to use a variant of the well known SEIR model to analyze the spread of COVID-19 in France, by taking in to account the national lockdown declared in March 11, 2020. Particle Swarm Optimisation (PSO) is used to find optimal parameters for the model in the case of France. We propose to fit the model based only on the number of daily fatalities, where an R2 score based error metric is used. As number of confirmed cases shall not be fully representative due to low testing especially in the first phases of the outbreak, we present that basing the model optimisation on the fatalities can provide legitimate results.


id: cord-264203-7dnz9yaa
author: Coldefy, Magali
date: 2010-10-10
txt: ./txt/cord-264203-7dnz9yaa.txt
cache: ./cache/cord-264203-7dnz9yaa.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pubmed/21055855/
doi: 10.1016/j.socscimed.2010.09.028
summary:
  It seems that trends depend on national context since a rather contrasting American study (Hunter, Shannon, & Sambrook, 1986) , reports the emergence and diffusion of public ''lunatic asylums'' in the United States during the 19th century, demonstrating how over time the establishment of these facilities spread from the north-east to the west of the country. To investigate spatial diffusion of psychiatric hospitals in France from the 19th century to the present day, the initial task involved building an original historical database of psychiatric hospitals, their location and date of establishment, indicating the points at which, in different parts of France, asylum facilities were first adopted as innovative care institutions for the mentally ill. For example, a psychiatric ward in a general hospital, could have constituted an ''acceptable'' way of caring for people with mental health problems in a département and such provision may have resulted in a delay in the establishment of a dedicated asylum facility in that area, or progressive independent institutions may have played a role in the dissemination of alienist ideas in psychiatry.

title:
  The geography of institutional psychiatric care in France 1800–2000: Historical analysis of the spatial diffusion of specialised facilities for institutional care of mental illness

abstract:
  As in other European countries, specialised psychiatric hospitals were established throughout France during the 19th Century. The construction of these hospitals can be considered as the concrete expression of a therapeutic innovation which recognized insanity as an illness that could be treated in such specialised institutions. The spatial diffusion of these innovative institutions through 19th and 20th century France is analysed and we explore how far this can be understood through theories of diffusion of innovations including geographical models of hierarchical and expansion diffusion (or whether other conceptual models are more appropriate). The research reported here particularly focuses on the period 1800–1961. It involved the construction of an original historical database of both psychiatric hospitals and information on the cities where these institutions were located. This was used to examine and interpret the different phases of development of psychiatric institutions and the parts of the country and types of geographical setting where they were concentrated. A multiple correspondence analysis was then performed to examine the connections between different aspects of the diffusion process. The study shows the limitations of classical models of spatial diffusion, which are found to be consistent with some, but not all aspects of the development of psychiatric institutions in France. An alternative political ecology approach seems more appropriate to conceptualise the various processes involved; national policies, social representations, medicalisation of care of mental illness, and urban and economic growth all seem to be associated with the emergence of a variable and complex pattern. This paper also opens a large field of research. Compared with other western countries, the geography of French psychiatric care is relatively under-researched, although there has been a strong spatial dimension to mental health policy in the country. This analysis provides a context for studies of more contemporary processes of French deinstitutionalisation, which is strongly structured by the past heritage of these large asylum facilities.


id: cord-267867-q52nvn0n
title: Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs
author: Chevalier, Christophe
date: 2016-12-14
txt: ./txt/cord-267867-q52nvn0n.txt
cache: ./cache/cord-267867-q52nvn0n.txt
extension: .txt
mime: text/plain
url: https://www.sciencedirect.com/science/article/pii/S152500161632439X
doi: 10.1038/sj.mt.6300186
summary:
  Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. We sought to determine whether the siRNAs si240-1a, si244, and si313, shown to be the most efficient in inhibiting the replication of HCV subgenomic replicons both transiently and under selective pressure, are also capable of efficiently blocking virus infection in cell culture.

abstract:
  Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and hepatocellular carcinoma, yet fully efficacious treatments are missing. In this study, we investigated RNA interference (RNAi), a specific gene silencing process mediated by small interfering RNA (siRNA) duplexes, as an antiviral strategy against HCV. Synthetic siRNAs were designed to target conserved sequences of the HCV 5′ nontranslated region (NTR) located in a functional, stem–loop structured domain of the HCV internal ribosome entry site (IRES), which is crucial for initiation of polyprotein translation. Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. One siRNA, targeting a sequence that is highly conserved across all genotypes and forms a critical pseudoknot structure involved in translation, was identified as the most promising therapeutic candidate. These results indicate that the HCV life cycle can be efficiently blocked by using properly-designed siRNAs that target functionally important, highly conserved sequences of the HCV IRES. This finding offers a novel approach towards developing IRES-based antiviral treatment for chronic HCV infections.


id: cord-272085-4mqc8mqd
title: Impact of Lockdown on the Epidemic Dynamics of COVID-19 in France
author: Roques, Lionel
date: 2020-06-05
txt: ./txt/cord-272085-4mqc8mqd.txt
cache: ./cache/cord-272085-4mqc8mqd.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pubmed/32582739/
doi: 10.3389/fmed.2020.00274
summary:
  Here, we develop a new mechanistic-statistical approach, based on a SIRD model (D being the dead cases compartment), in the aim of • estimating the effect of the lockdown in France on the contact rate and the effective reproduction number R e ; The computation of the solution of (1) with the posterior distribution of the parameters leads to a number of infectious I(t f ) = 7.0 · 10 5 and a total number of infected cases (including recovered) (I + R)(t f ) = 2.0 · 10 6 at the end of the observation period (April 14). We obtained an effective reproduction number that was divided by a factor 7, compared to the estimate of the R 0 carried out in France at the early stage of the epidemic, before the country went into lockdown [a value R 0 = 3.2 was obtained in (15) ].

abstract:
  The COVID-19 epidemic was reported in the Hubei province in China in December 2019 and then spread around the world reaching the pandemic stage at the beginning of March 2020. Since then, several countries went into lockdown. Using a mechanistic-statistical formalism, we estimate the effect of the lockdown in France on the contact rate and the effective reproduction number R(e) of the COVID-19. We obtain a reduction by a factor 7 (R(e) = 0.47, 95%-CI: 0.45–0.50), compared to the estimates carried out in France at the early stage of the epidemic. We also estimate the fraction of the population that would be infected by the beginning of May, at the official date at which the lockdown should be relaxed. We find a fraction of 3.7% (95%-CI: 3.0–4.8%) of the total French population, without taking into account the number of recovered individuals before April 1st, which is not known. This proportion is seemingly too low to reach herd immunity. Thus, even if the lockdown strongly mitigated the first epidemic wave, keeping a low value of R(e) is crucial to avoid an uncontrolled second wave (initiated with much more infectious cases than the first wave) and to hence avoid the saturation of hospital facilities.


id: cord-275827-r86ygqmy
title: Addictovigilance contribution during COVID-19 epidemic and lockdown in France
author: Lapeyre-Mestre, Maryse
date: 2020-06-23
txt: ./txt/cord-275827-r86ygqmy.txt
cache: ./cache/cord-275827-r86ygqmy.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pubmed/32660776/
doi: 10.1016/j.therap.2020.06.006
summary:
  In addition to this passive monitoring subject to under-reporting, other sources of information have been developed to improve vigilance: systematic data collection on falsified prescriptions from pharmacies ("ordonnances suspectes indicateur d''abus possible", OSIAP survey) [11, 12] and on secure prescription forms for narcotic drug prescriptions ( "antalgiques stupéfiants et ordonnances sécurisées", ASOS survey) [13] , systematic data collection from patients seen in addiction specialized structures ("observatoire des produits psychotropes illicites ou détournés de leur usage médicamenteux", OPPIDUM survey) [14] , analysis of toxicological data on chemical submission [15] or on deaths in a medico-legal framework ("décès en relation avec l''abus de médicaments et de substances", DRAMES survey) [16] . These early signals have been transmitted to national health authorities, leading to the implementation of a weekly specific monitoring of noteworthy cases or events related to the COVID-19, related to the lockdown, and of all falsified or abnormal prescription forms reported through the OSIAP survey during the period.

abstract:
  Abstract Addictovigilance is a safety monitoring targeted at substances with potential for abuse and dependence. This vigilance was involved during the period of COVID-19 epidemic due to the significant changes in access to drugs and psychological disruption caused by the pandemic and lockdown. This article aims to present the different steps implemented by the French Addictovigilance network in collaboration with the French Health authorities from March to May 2020, including monitoring of potential harmful events, and scientific communication. The first events were identified through the continuity of the networking between the French addictovigilance centres and their partners: community pharmacies, general practitioners, specialized structures and emergency wards. As soon as the lockdown began, first cases of overdoses (lethal or not) were reported with opioids, mainly with methadone, and other opioids (heroin, oxycodone, tramadol or antitussive codeine). Lockdown-related noteworthy events consisted in clinical cases or other relevant information for which lockdown clearly played an important role : among the many substances identified at least once, pregabalin, benzodiazepines, cannabis, cocaine and nitrous oxide were the most significant in terms of prevalence, seriousness or particularly specific to the lockdown context. Despite significant decrease in the activity and travel limited to vital needs, community pharmacies continued to identify falsified prescriptions in this period, highlighting an increase in suspicious requests for pregabalin, codeine and tramadol. In parallel, the French addictovigilance network continued its communications efforts in the period, issuing a newsletter on tramadol, a press release on methadone and naloxone, and participating in the COVID-19 frequently asked questions (FAQs) of the French Society of Pharmacology and Therapeutic website (https://sfpt-fr.org/covid19 ). COVID-19 epidemic has been an important challenge for addictovigilance, and has proved that this monitoring is highly essential for alerting health professionals and health authorities to points of vigilance in the field of psychoactive substances.


id: cord-282095-cbfyydi3
author: Pierron, Denis
date: 2020-10-14
url: https://www.ncbi.nlm.nih.gov/pubmed/33056983/
doi: 10.1038/s41467-020-18963-y
title:
  Smell and taste changes are early indicators of the COVID-19 pandemic and political decision effectiveness

abstract:
  In response to the COVID-19 pandemic, many governments have taken drastic measures to avoid an overflow of intensive care units. Accurate metrics of disease spread are critical for the reopening strategies. Here, we show that self-reports of smell/taste changes are more closely associated with hospital overload and are earlier markers of the spread of infection of SARS-CoV-2 than current governmental indicators. We also report a decrease in self-reports of new onset smell/taste changes as early as 5 days after lockdown enforcement. Cross-country comparisons demonstrate that countries that adopted the most stringent lockdown measures had faster declines in new reports of smell/taste changes following lockdown than a country that adopted less stringent lockdown measures. We propose that an increase in the incidence of sudden smell and taste change in the general population may be used as an indicator of COVID-19 spread in the population.


id: cord-284616-jgtsl06q
author: Harkouk, Hakim
date: 2020-05-04
txt: ./txt/cord-284616-jgtsl06q.txt
cache: ./cache/cord-284616-jgtsl06q.txt
extension: .txt
mime: text/plain
url: https://api.elsevier.com/content/article/pii/S2352556820300783
doi: 10.1016/j.accpm.2020.04.011
abstract: nan
summary:
  A regulatory team headed by an anaesthesiologist with the help of surgeons, usually meeting once a week, decides a new organisation evaluating rapidly both management of critical negative and positive COVID-19 patients and surgical activity; chronological details are listed in Table 1 The man-power includes 40 anaesthetist nurses and RR nurses and 10 anaesthesiologists (2 anaesthesiologists present 24 hours a day). This radical reorganisation within 2 weeks of an operating theatre and a RR relies on the professional, structural and material resources of an anaesthesia department to create an ICU with 10 beds dedicated to critical COVID-19 infected patients while maintaining the management of selected scheduled and emergency surgery. We report our experience with mobilisation of an anaesthesia team and use of existing structures for urgent creation of an ICU managing critical COVID-19 patients in a pandemic which exceeds the usual resources of resuscitation structures.

title:
  Urgent development of an anaesthesiology-based intensive care unit for critical COVID-19 infected patients


id: cord-285187-1h5tjs0r
title: An accelerated shift in the use of remote systems in epilepsy due to the COVID-19 pandemic
author: Kuchenbuch, Mathieu
date: 2020-08-31
txt: ./txt/cord-285187-1h5tjs0r.txt
cache: ./cache/cord-285187-1h5tjs0r.txt
extension: .txt
mime: text/plain
url: https://www.sciencedirect.com/science/article/pii/S1525505020305552
doi: 10.1016/j.yebeh.2020.107376
summary:
  PURPOSE: The purpose of the study was to describe epileptologists'' opinion on the increased use of remote systems implemented during the COVID-19 pandemic across clinics, education, and scientific meetings activities. Interestingly, before the COVID-19 pandemic, remote systems were significantly more frequently used in China for clinical activity compared with France or Italy. The aim of this study was to assess the impact of the COVID-19 pandemic on the acute use of remote systems in clinics, education, and scientific meetings in the field of epilepsy and to explore the users'' satisfaction and the perspectives of future use. We conducted a cross-sectional, electronic survey of epileptologists, neurologists, and pediatric neurologists mainly involved in the epilepsy field to determine the use of remote work during the COVID-19 pandemic (supplementary data). Before the COVID-19 pandemic, the rate of respondents who had experienced remote working systems was higher in China than in the two other countries (91.6% versus 61.7% for France and 25% for Italy, p = 10 −4 ).

abstract:
  PURPOSE: The purpose of the study was to describe epileptologists' opinion on the increased use of remote systems implemented during the COVID-19 pandemic across clinics, education, and scientific meetings activities. METHODS: Between April and May 2020, we conducted a cross-sectional, electronic survey on remote systems use before and during the COVID-19 pandemic through the European reference center for rare and complex epilepsies (EpiCARE) network, the International and the French Leagues Against Epilepsy, and the International and the French Child Neurology Associations. After descriptive statistical analysis, we compared the results of France, China, and Italy. RESULTS: One hundred and seventy-two respondents from 35 countries completed the survey. Prior to the COVID-19 pandemic, 63.4% had experienced remote systems for clinical care. During the pandemic, the use of remote clinics, either institutional or personal, significantly increased (p < 10(−4)). Eighty-three percent used remote systems with video, either institutional (75%) or personal (25%). During the pandemic, 84.6% of respondents involved in academic activities transformed their courses to online teaching. From February to July 2020, few scientific meetings relevant to epileptologists and routinely attended was adapted to virtual meeting (median: 1 [25th–75th percentile: 0–2]). Responders were quite satisfied with remote systems in all three activity domains. Interestingly, before the COVID-19 pandemic, remote systems were significantly more frequently used in China for clinical activity compared with France or Italy. This difference became less marked during the pandemic. CONCLUSION: The COVID-19 pandemic has dramatically altered how academic epileptologists carry out their core missions of clinical care, medical education, and scientific discovery and dissemination. Close attention to the impact of these changes is merited.


id: cord-288079-rr8h5dgy
author: Prague, Melanie
date: 2020-04-24
txt: ./txt/cord-288079-rr8h5dgy.txt
cache: ./cache/cord-288079-rr8h5dgy.txt
extension: .txt
mime: text/plain
url: https://doi.org/10.1101/2020.04.21.20073536
doi: 10.1101/2020.04.21.20073536
summary:
  title: Population modeling of early COVID-19 epidemic dynamics in French regions and estimation of the lockdown impact on infection rate Combining several French public datasets on the early dynamics of the epidemic, we estimate region-specific key parameters conditionally on this mechanistic model through Stochastic Approximation Expectation Maximization (SAEM) optimization using Monolix software. While traditional compartment models do not account for spatiality, we propose to take it into account by: i) modeling the epidemic at a finer, more homogeneous geographical scale (this is particularly important once lockdown is in place); ii) by using a population approach with random effects across French regions which allows each region to have relatively different dynamics while taking all information into account for the estimation of model parameters iii) aligning the initial starting time of the epidemic for all regions.

title:
  Population modeling of early COVID-19 epidemic dynamics in French regions and estimation of the lockdown impact on infection rate

abstract:
  We propose a population approach to model the beginning of the French COVID-19 epidemic at the regional level. We rely on an extended Susceptible-Exposed-Infectious-Recovered (SEIR) mechanistic model, a simplified representation of the average epidemic process. Combining several French public datasets on the early dynamics of the epidemic, we estimate region-specific key parameters conditionally on this mechanistic model through Stochastic Approximation Expectation Maximization (SAEM) optimization using Monolix software. We thus estimate basic reproductive numbers by region before isolation (between 2.4 and 3.1), the percentage of infected people over time (between 2.0 and 5.9% as of May 11th, 2020) and the impact of nationwide household confinement on the infection rate (decreasing the transmission rate by 72% toward a Re ranging from 0.7 to 0.9). We conclude that a lifting of the lockdown should be accompanied by further interventions to avoid an epidemic rebound.


id: cord-292475-jrl1fowa
author: Abry, Patrice
date: 2020-08-20
url: https://www.ncbi.nlm.nih.gov/pubmed/32817697/
doi: 10.1371/journal.pone.0237901
title:
  Spatial and temporal regularization to estimate COVID-19 reproduction number R(t): Promoting piecewise smoothness via convex optimization

abstract:
  Among the different indicators that quantify the spread of an epidemic such as the on-going COVID-19, stands first the reproduction number which measures how many people can be contaminated by an infected person. In order to permit the monitoring of the evolution of this number, a new estimation procedure is proposed here, assuming a well-accepted model for current incidence data, based on past observations. The novelty of the proposed approach is twofold: 1) the estimation of the reproduction number is achieved by convex optimization within a proximal-based inverse problem formulation, with constraints aimed at promoting piecewise smoothness; 2) the approach is developed in a multivariate setting, allowing for the simultaneous handling of multiple time series attached to different geographical regions, together with a spatial (graph-based) regularization of their evolutions in time. The effectiveness of the approach is first supported by simulations, and two main applications to real COVID-19 data are then discussed. The first one refers to the comparative evolution of the reproduction number for a number of countries, while the second one focuses on French departments and their joint analysis, leading to dynamic maps revealing the temporal co-evolution of their reproduction numbers.


id: cord-296081-6coxz3l8
title: COVID-19: Spatial Analysis of Hospital Case-Fatality Rate in France
author: SOURIS, M.
date: 2020-05-20
url: http://medrxiv.org/cgi/content/short/2020.05.16.20104026v1?rss=1
doi: 10.1101/2020.05.16.20104026
abstract:
  When the population risk factors and reporting systems are similar, the assessment of the case-fatality (or lethality) rate (ratio of cases to deaths) represents a perfect tool for analyzing, understanding and improving the overall efficiency of the health system. The objective of this article is to estimate the influence of the hospital care system on lethality in metropolitan France during the inception of the COVID-19 epidemic, by analyzing the spatial variability of the hospital case-fatality rate between French districts. The results show that the higher case-fatality rates observed in certain districts are mostly related to the level of morbidity in the district, therefore to the overwhelming of the healthcare systems during the acute phases of the epidemic. However, the magnitude of this increase of case-fatality rate represents less than 10 per cent of the average case-fatality rate and cannot explain the magnitude of the variations in case-fatality rate reported by country by international organizations or information sites. These differences can only be explained by the systems for reporting cases and deaths, which, indeed, vary greatly from country to country, and not attributed to the care or treatment of patients, even during hospital stress due to epidemic peaks.


id: cord-299846-yx18oyv6
title: Pandæsim: An Epidemic Spreading Stochastic Simulator
author: Amar, Patrick
date: 2020-09-18
txt: ./txt/cord-299846-yx18oyv6.txt
cache: ./cache/cord-299846-yx18oyv6.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pubmed/32962157/
doi: 10.3390/biology9090299
summary:
  The stochastic discrete version of Pandæsim showed very good correlations between the simulation results and the statistics gathered from hospitals, both on day by day and on global numbers, including the effects of the lockdown. The number of people of each age slice leaving their home sub-regions is a stochastic sample (or averaged value for the deterministic continuous solver) of a percentage of the population of this sub-region. Starting from an initial state (number of contagious people in each sub-region), the simulation algorithm iterates the following process at each timestep until either the epidemic ends or the maximum duration of the simulation is reached (defaults to 720 days). When the initial number of contagious people was relatively high, for example, in the Val-de-Marne sub-region (180), the results for both solvers were nearly identical: 5207 deaths for the average of 1000 stochastic runs and 5204 deaths for a deterministic run (Figures 2 and 3) .

abstract:
  SIMPLE SUMMARY: In order to study the efficiency of countermeasures used against the Covid-19 pandemic at the scale of a country, we designed a model and developed an efficient simulation program based on a well known discrete stochastic simulation framework along with a standard, coarse grain, spatial localisation extension. Our particular approach allows us also to implement deterministic continuous resolutions of the same model. We applied it to the Covid-19 epidemic in France where lockdown countermeasures were used. With the stochastic discrete method, we found good correlations between the simulation results and the statistics gathered from hospitals. In contrast, the deterministic continuous approach lead to very different results. We proposed an explanation based on the fact that the effects of discretisation are high for small values, but low for large values. When we add stochasticity, it can explain the differences in behaviour of those two approaches. This system is one more tool to study different countermeasures to epidemics, from lockdowns to social distancing, and also the effects of mass vaccination. It could be improved by including the possibility of individual reinfection. ABSTRACT: Many methods have been used to model epidemic spreading. They include ordinary differential equation systems for globally homogeneous environments and partial differential equation systems to take into account spatial localisation and inhomogeneity. Stochastic differential equations systems have been used to model the inherent stochasticity of epidemic spreading processes. In our case study, we wanted to model the numbers of individuals in different states of the disease, and their locations in the country. Among the many existing methods we used our own variant of the well known Gillespie stochastic algorithm, along with the sub-volumes method to take into account the spatial localisation. Our algorithm allows us to easily switch from stochastic discrete simulation to continuous deterministic resolution using mean values. We applied our approaches on the study of the Covid-19 epidemic in France. The stochastic discrete version of Pandæsim showed very good correlations between the simulation results and the statistics gathered from hospitals, both on day by day and on global numbers, including the effects of the lockdown. Moreover, we have highlighted interesting differences in behaviour between the continuous and discrete methods that may arise in some particular conditions.


id: cord-314884-110nqkej
title: Covid-19 And Vit-D: Disease Mortality Negatively Correlates With Sunlight Exposure
author: Lansiaux, Édouard
date: 2020-07-23
txt: ./txt/cord-314884-110nqkej.txt
cache: ./cache/cord-314884-110nqkej.txt
extension: .txt
mime: text/plain
url: https://www.sciencedirect.com/science/article/pii/S187758452030040X?v=s5
doi: 10.1016/j.sste.2020.100362
summary:
  In the current study, we applied a Pearson correlation test to public health as well as weather data, in order to assess the linear relationship between COVID-19 mortality rate and the sunlight exposure. In the current study, we applied a Pearson correlation test to public health as well as weather data, in order to assess the linear relationship between COVID-19 mortality rate and the sunlight exposure. For instance in continental metropolitan France, average annual sunlight hours are significantly (for a p-value of 1.532x10 -32 ) correlated to the COVID-19 mortality rate, with a Pearson coefficient of -0.636. Specifically in the context of continental metropolitan France, the correlation between sunlight exposure and SARS-CoV-2 infection will be studied in this article, by using an adjusted Pearson test applied to public health and weather data [13] [14] [15] .

abstract:
  The novel COVID-19 disease is a contagious acute respiratory infectious disease whose causative agent has been demonstrated to be a new virus of the coronavirus family, SARS-CoV-2. Alike with other coronaviruses, some studies show a COVID-19 neurotropism, inducing de-myelination lesions as encountered in Guillain-Barré syndrome. In particular, an Italian report concluded that there is a significant vitamin D deficiency in COVID-19 infected patients. In the current study, we applied a Pearson correlation test to public health as well as weather data, in order to assess the linear relationship between COVID-19 mortality rate and the sunlight exposure. For instance in continental metropolitan France, average annual sunlight hours are significantly (for a p-value of 1.532 × 10(−32)) correlated to the COVID-19 mortality rate, with a Pearson coefficient of -0.636. This correlation hints at a protective effect of sunlight exposure against COVID-19 mortality. This paper is proposed to foster academic discussion and its hypotheses and conclusions need to be confirmed by further research.


id: cord-318701-f9j13fsc
title: COVID‐19 pandemic in France: health emergency experiences from the field
author: Chamboredon, P.
date: 2020-06-22
txt: ./txt/cord-318701-f9j13fsc.txt
cache: ./cache/cord-318701-f9j13fsc.txt
extension: .txt
mime: text/plain
url: https://www.ncbi.nlm.nih.gov/pubmed/32567057/
doi: 10.1111/inr.12604
summary:
  On 12 March 2020, when WHO declared the status of a pandemic concerning the novel coronavirus (WHO 2020e), crisis measures were taken by the President of the French Republic (2020a) and his government, to control the epidemic and manage the health situation, namely, the closure of the nurseries, schools and universities for users as of 16 March 2020 ; the introduction of short-time work hours for employees whose companies cannot carry out their activities and of teleworking for all employees who have this possibility of adjusting the exercise of their profession (Ministry of Solidarity & Health 2020c). The health context made it possible to create the first telecare procedure related to the management of patients with COVID-19 by home nurses during the period of the state of health emergency (High Authority of Health 2020; Prime Minister of the French Government 2020c).

abstract:
  AIM: This paper describes the situation regarding COVID‐19 emergency in France as of early May 2020, the main policies to fight this virus, and the roles and responsibilities of nurses regarding their work at this time, as well as the challenges facing the profession. BACKGROUND: Europe continues to be affected by the COVID‐19 pandemic. At the time of writing France was the fourth country with the highest number of detected cases and cumulative deaths. SOURCES OF EVIDENCE: Websites of the World Health Organization, French Government, French Agency of Public Health, French National Council of Nurses and ClinicalTrials.gov database, as well as the experiences of the authors. DISCUSSION: The history of the development of the pandemic in France helps explain the establishment of the state of health emergency and containment of the population. Many decisions made had undesirable repercussions, particularly in terms of intra‐family violence, mental health disorders and the renunciation of care. Hospitals and primary care services, with significant investment by nurses, played a key role in the care of persons with and without COVID‐19. CONCLUSION: France has suffered a very high toll in terms of COVID‐19 morbidity and mortality, and effects on its people, health systems and health professionals, including nurses. IMPLICATIONS FOR NURSING PRACTICE: Nurses are recognized for their social usefulness in France. However, it is important to consider the collateral effects of this crisis on nurses and nursing and to integrate the health emergency nursing skills established during the pandemic into the standard field of nursing competence. IMPLICATIONS FOR NURSING POLICY: The nursing profession has expectations of a reflection on and revision of nursing skills as well as of its valorization in the French healthcare system, notably carried out by the French National Council Order of Nurses.


id: cord-319418-ao0df0q7
author: Chire Saire, J. E.
date: 2020-08-18
url: https://doi.org/10.1101/2020.08.15.20175810
doi: 10.1101/2020.08.15.20175810
title:
  Study of Coronavirus Impact on Parisian Population from April to June using Twitter and Text Mining Approach

abstract:
  The fast spreading of coronavirus name covid19, generated the actual pandemic forcing to change daily activities. Health Councils of each country promote health policies, close borders and start a partial or total lockdown. One of the first countries in Europe with high impact was Italy. Besides at the end of April, one country with a shared border was on the top of 10 countries with more total cases, then France started with its own battle to beat coronavirus. This paper studies the impact of coronavirus in the poopulation of Paris, France from April 23 to June 18, using Text Mining approach, processing data collected from Social Network and using trends related of searching. First finding is a decreasing pattern of publications/interest, and second is related to health crisis and economical impact generated by coronavirus.


id: cord-320636-mvtux07x
title: Underdetection of COVID-19 cases in France in the exit phase following lockdown
author: Pullano, G.
date: 2020-08-12
txt: ./txt/cord-320636-mvtux07x.txt
cache: ./cache/cord-320636-mvtux07x.txt
extension: .txt
mime: text/plain
url: https://doi.org/10.1101/2020.08.10.20171744
doi: 10.1101/2020.08.10.20171744
summary:
  Using age-stratified transmission models parameterized to behavioral data and calibrated to regional hospital admissions, we estimated that 69,115 [58,072-77,449] COVID-19 symptomatic cases occurred, suggesting that 9 out of 10 cases with symptoms were not ascertained. In France, the surveillance strategy implemented by authorities to exit lockdown on May 11, 2020 was multifold 2,3 and based on an expanded case definition for COVID-19 suspect cases to guide clinical diagnosis 4 ; recommendations to the general population to seek healthcare even in presence of mild symptoms; prescription of diagnostic tests to suspect cases by general practitioners for systematic and comprehensive testing; isolation of confirmed cases and tracing of their contacts. Here we estimated the rate of detection of COVID-19 symptomatic cases in France in May-June 2020 after lockdown, through the use of virological and participatory syndromic surveillance data coupled with mathematical transmission models calibrated to regional hospitalizations.

abstract:
  A novel testing policy was implemented in May in France to systematically screen potential COVID-19 infections and suppress local outbreaks while lifting lockdown restrictions. 20,736 virologically-confirmed cases were reported in mainland France from May 13, 2020 (week 20, end of lockdown) to June 28 (week 26). Accounting for missing data and the delay from symptom onset to confirmation test, this corresponds to 7,258 [95% CI 7,160-7,336] cases with symptom onset during this period, a likely underestimation of the real number. Using age-stratified transmission models parameterized to behavioral data and calibrated to regional hospital admissions, we estimated that 69,115 [58,072-77,449] COVID-19 symptomatic cases occurred, suggesting that 9 out of 10 cases with symptoms were not ascertained. Median detection rate increased from 7% [6-9]% to 31% [28-35]% over time, with regional estimates varying from 11% (Grand Est) to 78% (Normandy) by the end of June. Healthcare-seeking behavior in COVID-19 suspect cases remained low (31%) throughout the period. Model projections for the incidence of symptomatic cases (4.5 [3.9-5.0] per 100,000) were compatible with estimates integrating participatory and virological surveillance data, assuming all suspect cases consulted. Encouraging healthcare-seeking behavior and awareness in suspect cases is critical to improve detection. Substantially more aggressive and efficient testing with easier access is required to act as a pandemic-fighting tool. These elements should be considered in light of the currently observed resurgence of cases in France and other European countries.


id: cord-320773-zisujjsx
author: Sabat, Iryna
date: 2020-06-22
txt: ./txt/cord-320773-zisujjsx.txt
cache: ./cache/cord-320773-zisujjsx.txt
extension: .txt
mime: text/plain
url: https://api.elsevier.com/content/article/pii/S0168851020301639
doi: 10.1016/j.healthpol.2020.06.009
summary:
  It was particularly pronounced for intrusive policy measures, such as mobile data use for movement tracking, economic concerns, and trust in the information from the national government. In order to understand the public sentiment towards the COVID-19 containment measures and to inform future policy development, we collected information on people''s support for these policies, their worries in relation to the unfolding epidemic, and their trust in different sources of information. Overall, a north-south gradient could often be noticed in the EU regarding policy support: people living in the southern states (Portugal, Italy, and France) tended to approve of the containment policies more than residents in the northern countries (Denmark, Germany and the Netherlands). The first insights obtained from the data showed that containment and mitigating policies undertaken by national governments in response to the initial stages of the COVID-19 pandemic were generally wellreceived by the population in all countries covered by the survey.

title:
  United but divided: policy responses and people''s perceptions in the EU during the COVID-19 outbreak

abstract:
  To understand the public sentiment toward the measures used by policymakers for COVID-19 containment, a survey among representative samples of the population in seven European countries was carried out in the first two weeks of April 2020. The study addressed people's support for containment policies, worries about COVID-19 consequences, and trust in sources of information. Citizens were overall satisfied with their government's response to the pandemic; however, the extent of approval differed across countries and policy measures. A north-south divide in public opinion was noticeable across the European states. It was particularly pronounced for intrusive policy measures, such as mobile data use for movement tracking, economic concerns, and trust in the information from the national government. Considerable differences in people's attitudes were noticed within countries, especially across individual regions and age groups. The findings suggest that the epidemic acts as a stressor, causing health and economic anxieties even in households that were not directly affected by the virus. At the same time, the burden of stress was unequally distributed across regions and age groups. Based on the data collected, we draw lessons from the containment stage and identify several insights that can facilitate the design of lockdown exit strategies and future containment policies so that a high level of compliance can be expected.


id: cord-322943-lvdl7puw
author: Lardon, Zélie
date: 2010-06-22
url: https://www.ncbi.nlm.nih.gov/pubmed/20582307/
doi: 10.1371/journal.pntd.0000723
title:
  Imported Episodic Rabies Increases Patient Demand for and Physician Delivery of Antirabies Prophylaxis

abstract:
  BACKGROUND: Imported cases threaten rabies reemergence in rabies-free areas. During 2000–2005, five dog and one human rabies cases were imported into France, a rabies-free country since 2001. The Summer 2004 event led to unprecedented media warnings by the French Public Health Director. We investigated medical practice evolution following the official elimination of rabies in 2001; impact of subsequent episodic rabies importations and national newspaper coverage on demand for and delivery of antirabies prophylaxis; regular transmission of epidemiological developments within the French Antirabies Medical Center (ARMC) network; and ARMC discussions on indications of rabies post-exposure prophylaxis (RPEP). METHODOLOGY/PRINCIPAL FINDINGS: Annual data collected by the National Reference Center for Rabies NRCR (1989–2006) and the exhaustive database (2000–2005) of 56 ARMC were analyzed. Weekly numbers of patients consulting at ARMC and their RPEP- and antirabies-immunoglobulin (ARIG) prescription rates were determined. Autoregressive integrated moving-average modeling and regression with autocorrelated errors were applied to examine how 2000–2005 episodic rabies events and their related national newspaper coverage affected demand for and delivery of RPEP. A slight, continuous decline of rabies-dedicated public health facility attendance was observed from 2000 to 2004. Then, during the Summer 2004 event, patient consultations and RPEP and ARIG prescriptions increased by 84%, 19.7% and 43.4%, respectively. Moreover, elevated medical resource use persisted in 2005, despite communication efforts, without any secondary human or animal case. CONCLUSIONS: Our findings demonstrated appropriate responsiveness to reemerging rabies cases and effective newspaper reporting, as no secondary case occurred. However, the ensuing demand on medical resources had immediate and long-lasting effects on rabies-related public health resources and expenses. Henceforth, when facing such an event, decision-makers must anticipate the broad impact of their media communications to counter the emerging risk on maintaining an optimal public health organization and implement a post-crisis communication strategy.


id: cord-331509-p19dg1jw
author: Bigault, Lionel
date: 2020-05-31
txt: ./txt/cord-331509-p19dg1jw.txt
cache: ./cache/cord-331509-p19dg1jw.txt
extension: .txt
mime: text/plain
url: https://www.sciencedirect.com/science/article/pii/S0166093420301580?v=s5
doi: 10.1016/j.jviromet.2020.113906
summary:
  title: Porcine epidemic diarrhea virus: Viral RNA detection and quantification using a validated one-step real time RT-PCR In this study we described the development and validation of a SYBR™ Green one-step RT-qPCR according to the French norm NF U47-600, for the detection and quantification of PEDV viral RNA. Specificity and sensitivity, limit of detection (LoD), limit of quantification (LQ), linearity, intra and inter assay variability were evaluated using transcribed RNA and fecal and jejunum matrices spiked with virus. For a rapid, accurate and reliable diagnosis of PED in the veterinary laboratory, a method for the detection of PEDV viral RNA has been developed and more importantly validated according to the "Association Francaise de NORmalisation" (AFNOR) French NF U47-600 norm entitled "requirement and recommendation for the implementation, development and validation of PCR in animal health" (AFNOR, 2015a; AFNOR, 2015b) . This method should help harmonize detection and quantification of viral RNA from PEDV belonging to both S-non-INDEL and S-INDEL strains in both field and experimental settings.

title:
  Porcine epidemic diarrhea virus: Viral RNA detection and quantification using a validated one-step real time RT-PCR

abstract:
  Since 2014, porcine epidemic diarrhea virus (PEDV) has reemerged in Europe. RT-PCR methods have been described for the detection of PEDV, but none have been validated according to a norm. In this study we described the development and validation of a SYBR™ Green one-step RT-qPCR according to the French norm NF U47-600, for the detection and quantification of PEDV viral RNA. The method was validated from sample preparation (feces or jejunum) through to nucleic acid extraction and RT-qPCR detection. Specificity and sensitivity, limit of detection (LoD), limit of quantification (LQ), linearity, intra and inter assay variability were evaluated using transcribed RNA and fecal and jejunum matrices spiked with virus. The analytical and diagnostic specificities and sensitivities of this RT-qPCR were 100% in this study. A LoD of 50 genome copies/5 µl of extract from fecal matrices spiked with virus or RNA transcript and 100 genome copies/5 µl of extract from jejunum matrices spiked with virus were obtained. The Lower LQ (LLQ) was 100 genome copies/5 µl and the Upper LQ (ULQ) 10(8) copies/5 µl. This method is the first, validated according a norm for PEDV and may serve as a global reference method to harmonize detection and quantification of PEDV viral RNA in both field and experimental settings.


id: cord-335215-h9p4kmss
author: Follet, Jérôme
date: 2011-12-02
url: https://doi.org/10.1186/1297-9716-42-116
doi: 10.1186/1297-9716-42-116
title:
  Cryptosporidium infection in a veal calf cohort in France: molecular characterization of species in a longitudinal study

abstract:
  Feces from 142 animals were collected on 15 farms in the region of Brittany, France. Each sample was directly collected from the rectum of the animal and identified with the ear tag number. Animals were sampled three times, at 5, 15 and 22 weeks of age. After DNA extraction from stool samples, nested PCR was performed to amplify partial 18S-rDNA and 60 kDa glycoprotein genes of Cryptosporidium. The parasite was detected on all farms. One hundred out of 142 calves (70.4%) were found to be parasitized by Cryptosporidium. Amplified fragments were sequenced for Cryptosporidium species identification and revealed the presence of C. parvum (43.8%), C. ryanae (28.5%), and C. bovis (27%). One animal was infected with Cryptosporidium ubiquitum. The prevalence of these species was related to the age of the animal. C. parvum caused 86.7% of Cryptosporidium infections in 5-week-old calves but only 1.7% in 15-week-old animals. The analysis of the results showed that animals could be infected successively by C. parvum, C. ryanae, and C. bovis for the study period. C. parvum gp60 genotyping identifies 6 IIa subtypes of which 74.5% were represented by IIaA15G2R1. This work confirms previous studies in other countries showing that zoonotic C. parvum is the dominant species seen in young calves.


id: cord-335252-med3c01q
author: Fovet, Thomas
date: 2020-05-08
txt: ./txt/cord-335252-med3c01q.txt
cache: ./cache/cord-335252-med3c01q.txt
extension: .txt
mime: text/plain
url: https://www.sciencedirect.com/science/article/pii/S0013700620300877?v=s5
doi: 10.1016/j.encep.2020.05.002
summary:
  L''objectif de cet article est de décrire la réorganisation des soins psychiatriques en milieu pénitentiaire en contexte de pandémie de Covid-19 et d''interroger les conséquences du confinement et des libérations anticipées sur la santé mentale des personnes détenues. L''objectif de cet article est de décrire la réorganisation des soins psychiatriques en milieu pénitentiaire en contexte de pandémie de Covid-19 et d''interroger les conséquences du confinement et des libérations anticipées sur la santé mentale des personnes détenues. L''épidémie de Covid-19 semble avoir été plutôt contenue dans les prisons françaises au cours de la période de confinement mais le poids des mesures mises en place sur la population carcérale est important. L''épidémie de Covid-19 semble avoir été plutôt contenue dans les prisons françaises au cours de la période de confinement mais le poids des mesures mises en place sur la population carcérale est important.

title:
  Prisons confinées: quelles conséquences pour les soins psychiatriques et la santé mentale des personnes détenues en France?

abstract:
  Résumé Objectif. En France, les mesures de confinement ont été accompagnées de dispositions spécifiques pour les prisons: suspension des activités, parloirs et interventions extérieures. Plus de dix mille personnes détenues ont en outre été libérées pour diminuer le taux d’occupation des établissements et limiter la propagation du virus. L’objectif de cet article est de décrire la réorganisation des soins psychiatriques en milieu pénitentiaire en contexte de pandémie de Covid-19 et d’interroger les conséquences du confinement et des libérations anticipées sur la santé mentale des personnes détenues. Méthode. Ce travail s’appuie sur une enquête menée en avril 2020 auprès des soignants de 42 unités sanitaires en milieu pénitentiaire et des 9 unités hospitalières spécialement aménagées en France. Une synthèse de la littérature internationale sur la question des soins psychiatriques en milieu pénitentiaire durant l’épidémie de Covid-19 a également été réalisée. Résultats. L’épidémie de Covid-19 semble avoir été plutôt contenue dans les prisons françaises au cours de la période de confinement mais le poids des mesures mises en place sur la population carcérale est important. Les 3 niveaux de soins psychiatriques en milieu pénitentiaire ont instauré des mesures spécifiques pour assurer la continuité des soins, accompagner les personnes incarcérées et contenir l’épidémie. Parmi les plus importantes, on note la restriction des consultations, la création de « secteurs Covid », la déprogrammation des hospitalisations non urgentes, le renforcement des mesures d’hygiène et le remaniement des effectifs. Actuellement, les soignants sont principalement confrontés à des sevrages forcés, des symptomatologies anxieuses et des décompensations de troubles psychiatriques chroniques. Certaines libérations anticipées sont aussi très préoccupantes, pouvant entraîner des ruptures de soins, par manque de préparation des relais de prise en charge. Discussion. Les remaniements en lien avec le confinement donnent une visibilité accrue au fossé qui sépare la psychiatrie en milieu libre de la psychiatrie en milieu pénitentiaire. Il nous apparaît important de rappeler la vulnérabilité des personnes incarcérées qui doivent impérativement être considérées dans les politiques de santé publique. Abstract Objective. The impact of the Covid-19 pandemic on the 11 million people currently incarcerated worldwide is the subject of many concerns. Prisons and jails are filled with people suffering from many preexisting medical conditions increasing the risk of complications. Detainees’ access to medical services is already limited and overcrowding poses a threat of massive contagion. Beyond the health impact of the crisis, the tightening of prison conditions worries. On March 16, 2020, in France, the lockdown measures have been accompanied by specific provisions for prisons: all facilities have suspended visitations, group activities and external interventions. Over 10 000 prisoners have been released to reduce the prison population and the risk of virus propagation. These adjustments had major consequences on the healthcare system in French prisons. The objectives of this article are to describe the reorganization of the three levels of psychiatric care for inmates in France in the context of Covid-19 pandemic and to have a look at the impact of lockdown measures and early releases on mental health of prisoners. Methods. This work is based on a survey conducted in April 2020 in France among psychiatric healthcare providers working in 42 ambulatory units for inmates and in the 9 full-time inpatient psychiatric wards exclusively for inmates called “UHSAs” (which stands for “unités hospitalières spécialement aménagées”, and can be translated as “specially equipped hospital units”). A review of the international literature on mental healthcare system for inmates during the Covid-19 epidemic has also been performed. Results. The Covid-19 epidemic has been rather contained during the period of confinement in French prisons but the impact of confinement measures on the prison population is significant. The three levels of psychiatric care for inmates have implemented specific measures to ensure continuity of care, to support detainees during Coronavirus lockdown and to prevent an infection’s spread. Among the most important are: limitation of medical consultations to serious and urgent cases, creation of “Covid units”, cancellation of voluntary psychiatric hospitalizations, reinforcement of preventive hygiene measures and reshuffling of medical staff. Prolonged confinement has consequences on mental health of detainees. Currently, mental health workers are facing multiple clinical situations such as forced drug and substance withdrawal (linked to difficulties in supplying psychoactive substances), symptoms of anxiety (due to concerns for their own and their relatives’ wellbeing) and decompensation among patients with severe psychiatric conditions. Early releases from prison may also raise some issues. People recently released from prison are identified as at high risk of death by suicide and drug overdose. The lack of time to provide the necessary link between health services within prisons and health structures outside, could have serious consequences, emphasizing the well-known “revolving prison doors” effect. Discussion. The current lockdown measures applied in French jails and prisons point out the disparities between psychiatric care for inmates and psychiatric care for general population. Giving the high vulnerability of prison population, public health authorities should pay more attention to health care in prisons.


id: cord-335297-vxhta6a4
title: Chyloabdomen in a cat with pancreatic carcinoma
author: Véran, Emilie
date: 2018-11-24
txt: ./txt/cord-335297-vxhta6a4.txt
cache: ./cache/cord-335297-vxhta6a4.txt
extension: .txt
mime: text/plain
url: https://doi.org/10.4314/ovj.v8i4.16
doi: 10.4314/ovj.v8i4.16
summary:
  Cases in dogs were reported in association with intestinal lymphangiectasia (Peterson, 1996) , mediastinal lymphangiosarcoma (Myers et al., 1966) , acute pancreatitis (Lott et al., 2015) , abdominal lymphatic rupture (Fossum et al., 1992) , complication of mesenteric lymphangiography for chylothorax (Fossum et al., 1992) , and lymphatic obstruction secondary to thrombus formation (Fossum et al., 1992) . A case of chylous pleural and peritoneal effusion with no underlying cause was described in a cat, with no postmortem examination performed (Thompson and Carr, 2002) . (2013) previously reported 34 feline cases of pancreatic carcinoma; chylous ascites was present in one cat in this series. By analogy, rutin has been unsuccessfully used in a case of chyloabdomen secondary to hypertrophic cardiomyopathy and a chylous pleural and peritoneal effusion with no underlying condition (Nelson, 2001; Thompson and Carr, 2002) .

abstract:
  A 12-year-old spayed female domestic shorthair cat was evaluated for a 3-week history of abdominal distension. Chyloabdomen secondary to pancreatic carcinoma was diagnosed. The cat was palliatively managed using rutin and a low-fat diet. The etiology, diagnosis and management of chyloabdomen are discussed.


id: cord-337744-g17qe8fi
title: Population mobility reductions during COVID-19 epidemic in France under lockdown
author: Pullano, G.
date: 2020-06-01
txt: ./txt/cord-337744-g17qe8fi.txt
cache: ./cache/cord-337744-g17qe8fi.txt
extension: .txt
mime: text/plain
url: http://medrxiv.org/cgi/content/short/2020.05.29.20097097v1?rss=1
doi: 10.1101/2020.05.29.20097097
summary:
  Lockdown caused a 65% reduction in countrywide number of displacements, and was particularly effective in reducing work-related short-range mobility, especially during rush hours, and recreational long-range trips. Accurately measuring changes in human mobility under these restrictions is essential to (i) quantitatively determine how imposed measures and recommendations (e.g. regarding telework where possible, ban of leisure trips) translated into reduced mobility at specific scales and times, (ii) inform models estimating the effectiveness of the ongoing lockdown in reducing the epidemic spread 3,4 , (iii) help devising social distancing measures needed for the post-lockdown phase. The impact of nationwide lockdown in the reduction of outgoing mobility per region was strongly associated with the fraction of the population in the most active age range (24-59 y.o.) 24 (Pearson r = 0.91, p < 0.01) and the fraction of workers employed in sectors that substantially modified their organization during lockdown, due to telework, partial or full closure of activities (Pearson r = 0.80, p < 0.01) (Table 1 and Figure 4) .

abstract:
  On March 17, 2020, French authorities implemented a nationwide lockdown to respond to COVID-19 epidemic emergency and curb the surge of patients requiring critical care, similarly to other countries. Evaluating the impact of lockdown on population mobility is important to help characterize the changes in social dynamics that affected viral diffusion. Using travel flows reconstructed from mobile phone trajectories, we measured how lockdown altered mobility patterns at both local and country scales. Lockdown caused a 65% reduction in countrywide number of displacements, and was particularly effective in reducing work-related short-range mobility, especially during rush hours, and recreational long-range trips. Anomalous increases in long-range movements, localized in both time and space, emerged even before lockdown announcement. Mobility drops were unevenly distributed across regions. They were strongly associated with active population, workers employed in sectors highly impacted by lockdown, and number of hospitalizations per region, and moderately associated with socio-economic level of the region. Major cities largely shrank their pattern of connectivity, reducing it mainly to short-range commuting, despite the persistence of some long-range trips. Our findings indicate that lockdown was very effective in reducing population mobility across scales. Caution should be taken in the timing of policy announcements and implementation. Individual response to policy announcements may generate unexpected anomalous behaviors increasing the risk of geographical diffusion. On the other hand, risk awareness may be beneficial in further decreasing mobility in largely affected regions. Our findings help predicting how and where restrictions will be the most effective in reducing the mobility and mixing of the population, thus aiding tuning recommendations in the upcoming weeks, when phasing out lockdown.


id: cord-339820-x8r27w14
title: Transport effect of COVID-19 pandemic in France
author: Guan, L.
date: 2020-07-29
txt: ./txt/cord-339820-x8r27w14.txt
cache: ./cache/cord-339820-x8r27w14.txt
extension: .txt
mime: text/plain
url: https://doi.org/10.1101/2020.07.27.20161430
doi: 10.1101/2020.07.27.20161430
summary:
  50 Based on regional model analysis before and after the lockdown, we present a network model to characterize the pandemic transmission between regions in France after lockdown and evaluate the transport effect of COVID-19 pandemic, when considering all age classes together. In this section, regional scales of France are considered and all age classes are summed to calibrate the parameters of the pandemic model (6)-(13) during 12 All rights reserved. In this section, the general form of an integro-differential model capable of integrating different age classes and areas is introduced to discuss the transport effect of COVID-19 in France after lockdown. . https://doi.org/10.1101/2020.07.27.20161430 doi: medRxiv preprint Equation (40) describes the network dynamics of COVID-19 pandemic after lockdown and the transport effect on different age class on the basis of the regional pandemic transmission dynamics during lockdown.

abstract:
  An extension of the classical pandemic SIRD model is considered for the regional spread of COVID-19 in France under lockdown strategies. This compartment model divides the infected and the recovered individuals into undetected and detected compartments respectively. By fitting the extended model to the real detected data during the lockdown, an optimization algorithm is used to derive the optimal parameters, the initial condition and the epidemics start date of regions in France. Considering all the age classes together, a network model of the pandemic transport between regions in France is presented on the basis of the regional extended model and is simulated to reveal the transport effect of COVID-19 pandemic after lockdown. Using the the measured values of displacement of people mobilizing between each city, the pandemic network of all cities in France is simulated by using the same model and method as the pandemic network of regions. Finally, a discussion on an integro-differential equation is given and a new model for the network pandemic model of each age class is provided.


id: cord-340298-0l4pec0z
title: Impact of virus testing on COVID-19 case fatality rate: estimate using a fixed-effects model
author: Terriau, A.
date: 2020-05-01
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url: https://doi.org/10.1101/2020.04.26.20080531
doi: 10.1101/2020.04.26.20080531
summary:
  title: Impact of virus testing on COVID-19 case fatality rate: estimate using a fixed-effects model Methods We use data on inpatients across French geographic areas and propose a novel methodology that exploits policy discontinuities at region borders to estimate the effect of COVID-19 tests on the case-fatality rate. Screening policies and mortality rate might be related to the fact that testing allows authorities to detect and isolate infected people and to prevent them from transmitting the virus; and also enables early treatment, thus increasing the chances of cure. We used a fixed-effects model to assess the impact of the number of tests performed over time at a local geographical level (department) on fatality-cases. Our strategy consisted in comparing all contiguous department pairs sharing a region border (See Figure 1 for an example) to identify the effect of testing on the case fatality rate.

abstract:
  Background In response to the SARS-CoV2 pandemic, governments have adopted a variety of public health measures. There are variations in how much testing has been done across countries. South Korea, Germany, and Iceland take the bet of massive testing of their population. Whereas tests were not performed widely in southern European countries. As the former undergo a lower case-fatality rate due to the COVID-19 than the latter, the impact of the testing strategy must be investigated. In this study, we aimed to evaluate the impact of testing on the case fatality rate. Methods We use data on inpatients across French geographic areas and propose a novel methodology that exploits policy discontinuities at region borders to estimate the effect of COVID-19 tests on the case-fatality rate. In France, testing policies are determined locally. We compare all contiguous department pairs located on the opposite sides of a region border. The heterogeneity in testing rate between department pairs together with the similarities in other dimensions allow us to mimic the existence of treatment and control groups and to identify the impact of testing on mortality. Results The increase of one percentage point in the test rate is associated with a decrease of 0.001 percentage point in the death rate. In other words, for each additional 1000 tests, one person would have remained alive. Conclusion Massive population testing could have a significant effect on mortality in different ways. Mass testing may help decision-makers to implement healthcare measures to limit the spread of the disease.


id: cord-344020-8poerd09
title: Autochthonous dengue in two Dutch tourists visiting Département Var, southern France, July 2020
author: Vermeulen, Tom D
date: 2020-10-01
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url: https://www.ncbi.nlm.nih.gov/pubmed/33006305/
doi: 10.2807/1560-7917.es.2020.25.39.2001670
summary:
  We report dengue virus (DENV) infection in two Dutch tourists who visited Département Var, southern France, in July and August 2020. We report dengue virus (DENV) infection in two Dutch tourists who visited Département Var, southern France, in July and August 2020. As some autochthonous dengue cases have occurred in Europe in recent years, awareness among physicians and public health experts about possible intermittent presence of DENV in southern Europe is important to minimise delay in diagnosis and treatment. As some autochthonous dengue cases have occurred in Europe in recent years, awareness among physicians and public health experts about possible intermittent presence of DENV in southern Europe is important to minimise delay in diagnosis and treatment. On August 27, upon confirmation of the serological results, Patient 1 was reported by the RIVM to the French authorities through the Early Warning and Response System of the European Union as an autochthonous DENV infection probably acquired in France with cross-border implication.

abstract:
  We report dengue virus (DENV) infection in two Dutch tourists who visited Département Var, southern France, in July and August 2020. As some autochthonous dengue cases have occurred in Europe in recent years, awareness among physicians and public health experts about possible intermittent presence of DENV in southern Europe is important to minimise delay in diagnosis and treatment. Quick diagnosis can lead to timely action to contain the spread of vector-borne diseases and minimise transmission.


id: cord-344984-mg779mix
author: Bitar, Dounia
date: 2009-11-30
url: https://www.sciencedirect.com/science/article/pii/S0001407919324185
doi: 10.1016/s0001-4079(19)32418-5
title:
  Risques d’importation des maladies infectieuses exotiques en France métropolitaine : détection, alerte et réponse

abstract:
  SUMMARY The French public health institute is responsible for promoting and coordinating threats the detection and assessment of health risks, and for suggesting possible responses. Transmissible diseases affecting both human and animal health are the focus of surveillance networks. Early detection of potential infectious threats is based on the screening of “ alert signals “ identified through routine surveillance networks and other systems. The quality and accuracy of these signals is first verified, before assessing, through a multidisciplinary approach, the risk of introduction and dissemination. This article examines specific cases illustrating the process of detection, risk analysis and response, with respect to infectious threats that are endemic in tropical regions and have the potential to be imported into metropolitan France. For both novel pathogens and exotic diseases — which, not being endemic in France, are less well known — the analysis and response process must regularly be adapted to the latest epidemiological, clinical and biological findings, taking interactions between the pathogen, host, and environment into consideration. The need to improve reaction times and risk assessment is also discussed.


id: cord-347244-abxv2mkz
title: Hepatitis E Virus Strains in Rabbits and Evidence of a Closely Related Strain in Humans, France
author: Izopet, Jacques
date: 2012-08-17
url: https://www.ncbi.nlm.nih.gov/pubmed/22840216/
doi: 10.3201/eid1808.120057
abstract:
  Hepatitis E virus (HEV) strains from rabbits indicate that these mammals may be a reservoir for HEVs that cause infection in humans. To determine HEV prevalence in rabbits and the strains’ genetic characteristics, we tested bile, liver, and additional samples from farmed and wild rabbits in France. We detected HEV RNA in 7% (14/200) of bile samples from farmed rabbits (in 2009) and in 23% (47/205) of liver samples from wild rabbits (in 2007–2010). Full-length genomic sequences indicated that all rabbit strains belonged to the same clade (nucleotide sequences 72.2%–78.2% identical to HEV genotypes 1–4). Comparison with HEV sequences of human strains and reference sequences identified a human strain closely related to rabbit strain HEV. We found a 93-nt insertion in the X domain of open reading frame 1 of the human strain and all rabbit HEV strains. These findings indicate that the host range of HEV in Europe is expanding and that zoonotic transmission of HEV from rabbits is possible.


id: cord-350571-6tapkjb6
author: nan
date: 2017-01-10
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url: https://www.ncbi.nlm.nih.gov/pubmed/28074393/
doi: 10.1007/s11096-016-0404-4
abstract: nan
summary:
  Possible solutions might be to use shared communication tools like Internet based communication programs and to introduce the patient as a participant at the IMRs. Please specify your abstract type: Research abstract Background and objective: International good pharmacy practice guidelines describe how pharmacists should counsel the patients about their medicines, offer additional services where needed, and intervene at drug related problems. Please specify your abstract type: Descriptive abstract (for projects) Background and objective: In order to improve the medication reconciliation and to implement training programs for the medical team in an associated to general hospital nursing (ASNH) home we measured the discrepancies between pharmacy registered treatments (PRT) and medical prescriptions (MP), and we analysed potentially inappropriate prescriptions according to ''''American Geriatrics Society 2015 Beers Criteria'''' and ''''STOPP-START 2014 criteria.

title:
  45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016


id: cord-355038-o2hr5mox
title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress
author: nan
date: 2020-02-11
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url: https://www.ncbi.nlm.nih.gov/pubmed/32048060/
doi: 10.1186/s13613-020-0623-7
abstract: nan
summary:
  Conclusion: In patients with moderate-to-severe ARDS, a higher tidal volume under PSV within the 72 h following neuromuscular blockers cessation is independently associated with the 28-day mortality.Compliance with ethics regulations: Yes. Kaplan-Meier estimate of the cumulative probability of survival according to the mean tidal volume (Vt)-lower of higher than 8 ml/ kg-under pressure support ventilation (PSV) during the "transition period" transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical setting. Compliance with ethics regulations: Yes. Patients and methods: In a retrospective monocentric study (01/2013-01/2017) conducted in cardio-vascular surgical intensive care unit (ICU) in Henri Mondor teaching hospital, all consecutive adult patients who underwent peripheral VA-ECMO were included, with exclusion of those dying in the first 24 h. Compliance with ethics regulations: Yes. Rationale: Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients and the need for invasive mechanical ventilation has become a major clinical end-point in randomized controlled trials (RCT).


id: cord-355549-6xnjj5h5
author: Cécile, Couchoud
date: 2020-08-25
txt: ./txt/cord-355549-6xnjj5h5.txt
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url: https://www.sciencedirect.com/science/article/pii/S0085253820309595?v=s5
doi: 10.1016/j.kint.2020.07.042
summary:
  The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. The aim of this first report from the French REIN registry is to describe the population of infected dialysis patients and their course of illness, estimate the incidence and lethality of COVID-19 disease and identify the risk factors associated with the probability of death. This can also be associated with the implementation of all the necessary preventive actions prone by the SFNDT, including 1/wearing a mask during transport and for the entire period of care, 2/systematic tracking of patients and screening at the entrance to dialysis units based on fever and symptoms or contact with an infected person and 3/restricting areas for COVID-19 cases (18),.

title:
  Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients.

abstract:
  The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed.


