cord-000425-isw6jeir	2011	A study on Yorkshire pigs selected for eight generations for high and low adaptive IR (HIR and LIR, respectively) on an index combining four standardized measures of specific antibodies and cellmediated IR, after stimulation with specific antigens (bacillus Calmette-Guérin and hen egg white lysozyme), has revealed that HIR and LIR animals differ in response to immunization and infection [2, 11, 12, 13, 14] . Finally, several significant QTLs for total leukocyte count ( [20, 21] ; Animal-QTLdb, http://www.animalgenome.org/cgi-bin/QTLdb/index), mitogen-induced proliferation [20] , antibody response [20, 22] , cytokine production (IL10 and IFNc) [23] , complement activity [22] , and acute phase protein serum concentration [22] have been detected and mapped to different pig chromosomes. In this report, we present the results of a global genetic study, combining principal component analysis (PCA), and genetic parameter estimation applied to a large number of innate and adaptive ITs in a pig population vaccinated against Mycoplasma hyopneumoniae (M.
cord-004534-jqm1hxps	2009	HIV-1 to efficiently complete a replication cycle has to integrate its genome into the host cellular DNA.After HIV-1 enters target cells,neosynthesized viral DNA forms along with other proteins the pre-integration complex (PIC).PICs are then transported into the nucleus where integration,catalyzed by the viral integrase,takes place.HIV-1 viral particles engineered to incorporate integrase fused to EGFP have proven effective to study PICs within nuclei of infected cells.In this study we report the live imaging analysis of nuclear PIC dynamics obtained by time-lapse microscopy.Intranuclear trajectories of IN-EGFP-labeled PIC were collected in three dimensions and examined by both mean squared displacement (MSD) and cage diameter (CD) analysis.In CD the maximum distances measured between two positions occupied by a PIC in a time window of 2 minutes were calculated while in our MSD analysis 5-minute long trajectory segments were considered.Remarkably,MSD revealed the presence of an underlying active transport mechanism.To test the possible role of actin filaments,PIC nuclear trafficking was analyzed in cells treated with latrunculin B (actin polymerization inhibitor).Preliminary results suggest that the disruption of actin function impairs the active nuclear movement of PICs. Second harmonic generation microscopy reveals sarcomere contractile dynamics of cardiomyocytes N.
cord-007890-bie1veti	2002	Effects of Interferon alpha plus ribavirine therapy on frequencies of HCV, HIV and CMV specific CD4-T-cell responses in peripheral blood of HIV/HCV coinfected patients after 6 months of treatment SoA9.5 Methods: Two groups of patients with chronic HCV infection were studied: 26 HIV coinfected progressors with antiretroviral therapy and 13 HIV-negative controls. In order to assess the local temporal trend of antibiotic sensitivity of the most common urinary tract bacterial pathogen, all urine-cultured Escherichia coli isolates were reviewed as to susceptibility profile, and specimen source (community-versus hospital-acquired infection). Methods: A total of 87 penicillin resistant clinical strains isolated from patients at Hacettepe Children''s Hospital, Ankara, Turkey between 1999 and 2001 were tested for their in vitro susceptibility to various antibiotics that are commonly used in the treatment of respiratory tract infections.
cord-014538-6a2pviol	2017	Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality).
cord-014685-ihh30q6f	2005	This study has attempted to analyse the structural properties of membrane peptides and proteins through the use of model systems that have been designed to mimic their natural counterparts: Podlubnaya 2 1 Institute of Theoretical and Experimental Biophysics RAS, 2 Pushchino State University Amyloid brils are formed by proteins or their peptides in the result of a conformational transition from alpha helix into beta-sheet structure. Analysis of the results of such studies indicate that folding of SNase fragments is dominated by developing the local and non-local nucleation sites from native-like secondary structures and by intensifying the longrange interactions of residues at nucleation sites with residues further removed in sequence. The results show that at different pH values the aggregation processes of both proteins follow different pathways determined by the variations in the native structure and by the details of the involved conformational changes.
cord-015334-8p124rwp	2008	Based on the results of the pharmacoeconomic analysis, development of clinical pharmacy and CIVAS for some drugs will be discussed with the paediatric department Background and Objective: Studies show that up to 38% of patients starting treatment with antidepressants fill only a single prescription at the pharmacy, apparently not accepting treatment. Main Outcome Measures: Data collected were: nurses'' profile (age, length of service, competencies'' self-assessment), knowledge on drugs prescribed to their patients (usage, administration, side-effects, drug interactions…), use of existing tools (i.e. drugs database) and possible tools to be developed by the pharmacy ward to help them in their daily practice. The objectives were:(1)To identify the most relevant minor ailments, agreeing on the specific criteria for referral to the GP.(2)To select the non-prescription drugs, with evidence of safety and effectiveness, for the treatment of the identified minor ailments Design: Qualitative study with an expert panel which was made up of 2 primary care physician from SEMFYC and six community pharmacists (two members of SEFAC and four members of GIAF-UGR).
cord-016095-jop2rx61	2010	Instead of setting out to discover unknown mechanisms by analyzing effects that are dependent on specific causes, with some uncertainty as to the possible success of the enterprise being undertaken, which is the foundation stone of the Bernardian paradigm of the experimental method, many current research projects give themselves achievable and programmable objectives that depend upon the means available to them: sequencing of genomes with a view to comparing them, recognition of sequence similarities in proteins coded for by genes belonging to different species, with the aim of putting together phylogenetic trees, synthesis of interesting proteins in transgenic animals and plants, analysis of the three-dimensional structure of proteins, in order to find sites that are likely to fix medicinal substances, and synthesis of molecular species able to recognize pathogenic targets.
cord-021158-075vh5jg	2020	Using recent debates on the AMR problem, it proposes to examine the relationship between the development of professional veterinary expertise and of the drug market, based on the case of a specific segment of the profession, namely veterinarians specializing in industrial poultry and pig production in western France. Indeed, it is common to hear professional organizations or public authorities state that in order to reduce their economic dependence on antibiotic sales, vets must rethink their activity by favouring preventive approaches to animal health which would involve a diversified range of services and would contribute to placing vets in an advisory role with a holistic vision of livestock farming or even of the food supply chain (VetFuturs France 2018) .
cord-023049-fio7cjj5	2017	Clinical efficacy (Medical Research Council sum score, 10-m walk, modified Inflammatory Neuropathy Cause and Treatment score, Overall Neuropathy Limitations Scale, Romberg test) and patient-reported outcomes (36-item Short Form Health Survey , Life Quality Index [LQI] ) were assessed at baseline and at regular intervals until the final visit (10-14 months after switching). To explore the issue of early biomarkers in FAP, we performed skin biopsy and compared IENF density with parameters of nerve conduction studies (NCS) and quantitative sensory testing (QST) on 36 subjects (23 men, aged 55.1 ± 11.1 years) with genetic confirmation of TTR-A97S: 17 patients and 19 carriers. Results: The Gly112Ser mutation causing CMT1C is a mild form of CMT, as patients walked on time, had less weakness than those with Charcot-Marie-Tooth Disease type 1A (CMT1A), had a Charcot Marie Tooth neuropathy score (CMTNS) indicative of mild disease, and had faster ulnar and median motor nerve conduction velocities compared to those with CMT1A.
cord-252950-eiphxwmn	2020	COVID patients in ICU present a high mortality rate and immunoprofiling reveals heterogeneous IFN-α2 production with about 20% of critically-ill patients unable to produce IFN-α2, highlighting the immune response heterogeneity and opening avenues for targeted therapies. 42 Capsule summary: 43 COVID patients in ICU present a high mortality rate and immunoprofiling reveals heterogeneous α2 production with about 20% of critically-ill patients unable to produce IFN-α2, highlighting the 45 immune response heterogeneity and opening avenues for targeted therapies. Various immunosuppressive drugs, including IL-6 blockers or JAK-STAT signaling inhibitors have been 56 suggested for the treatment of SARS-COV-2 infection 2 whereas additional clinical trials are evaluating 57 the use of recombinant interferon to foster host antiviral response. To date, IFN-I response has not been evaluated in COVID-19 60 patients and its contribution to the viral control and inflammation is unknown. We further explored a larger cohort of 26 critically ill COVID patients from one of the intensive care 75 unit (ICU) at Hospices Civils de Lyon (Lyon, France).
cord-253801-y1nherse	2009	title: Risque d''introduction et voies d''importation par l''homme de maladies infectieuses exotiques : cas particulier de l''émergence de bactéries pathogènes multirésistantes aux antibiotiques, importées en France à l''occasion de voyages internationaux ou du rapatriement de patients hospitalisés à l''étranger Le rapatriement sanitaire de français hospitalisés à l''étranger, mais aussi les simples retours de voyage et la prise en charge sanitaire d''étrangers en voyage en France, quelle que soit leur nationalité, expose donc la population française à des bactéries multirésistantes aux antibiotiques qui auraient pu être acquises dans des zones de haute prévalence de résistance. On sait toutefois qu''il est réel et des évènements sporadiques ou épidémiques ont été observés concernant des pathogènes tels que Mycobacterium tuberculosis multirésistant, Clostridium difficile de ribotype 027, Klebsiella pneumoniae productrice de carbapénèmase, Acinetobacter baumannii multirésistant, Staphylococcus aureus résistant à la méticilline commu-Bull.
cord-257325-pvf0uon3	2020	Objectives We aimed to investigate possible differences in aggregated hospital-fatality rate from COVID-19 in France at the early phase of the outbreak, and to determine whether factors related to population or healthcare supply before the pandemic could be associated with outcome differences. After multivariable analysis, four factors were independently associated with a significantly higher aggregated hospital-fatality rate: a higher ICU capacity at baseline (estimate=1.47; p=0.00791), a lower density of general practitioners (estimate=0.95; p=0.0205), a higher fraction of activity from the for-profit private sector (estimate=0.99; p<0.001), and the ratio of people over 75 (estimate=0.91; p=0.0023). Apart from the population, four factors were independently associated with a significantly higher aggregated hospital-fatality rate from Covid-19: a higher ICU capacity at baseline (estimate=1.47; p=0.00791), a lower density of general practitioners (estimate=0.95; p=0.0205), a higher fraction of activity from the for-profit private sector (estimate=0.99; p<0.001) and the ratio of people over 75 (estimate=0.91; p=0.0023).
cord-262046-bb8ekgdm	2020	We propose to use a variant of the well known SEIR model to analyze the spread of COVID-19 in France, by taking in to account the national lockdown declared in March 11, 2020. As number of confirmed cases shall not be fully representative due to low testing especially in the first phases of the outbreak, we present that basing the model optimisation on the fatalities can provide legitimate results. Note that, with this approach the initial state values are also defined in terms of proportion of fatalities, hence they also are parameters of the PSO optimization. Using the developed model we predict that if lockdown continues with strict measures, the total number of COVID-19 fatalities should topple below 50,000 (which is currently around 20,000) by late August, 2020; where the effects of the epidemic start to significantly diminish.
cord-264203-7dnz9yaa	2010	It seems that trends depend on national context since a rather contrasting American study (Hunter, Shannon, & Sambrook, 1986) , reports the emergence and diffusion of public ''lunatic asylums'' in the United States during the 19th century, demonstrating how over time the establishment of these facilities spread from the north-east to the west of the country. To investigate spatial diffusion of psychiatric hospitals in France from the 19th century to the present day, the initial task involved building an original historical database of psychiatric hospitals, their location and date of establishment, indicating the points at which, in different parts of France, asylum facilities were first adopted as innovative care institutions for the mentally ill. For example, a psychiatric ward in a general hospital, could have constituted an ''acceptable'' way of caring for people with mental health problems in a département and such provision may have resulted in a delay in the establishment of a dedicated asylum facility in that area, or progressive independent institutions may have played a role in the dissemination of alienist ideas in psychiatry.
cord-267867-q52nvn0n	2016	Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. We sought to determine whether the siRNAs si240-1a, si244, and si313, shown to be the most efficient in inhibiting the replication of HCV subgenomic replicons both transiently and under selective pressure, are also capable of efficiently blocking virus infection in cell culture.
cord-272085-4mqc8mqd	2020	Here, we develop a new mechanistic-statistical approach, based on a SIRD model (D being the dead cases compartment), in the aim of • estimating the effect of the lockdown in France on the contact rate and the effective reproduction number R e ; The computation of the solution of (1) with the posterior distribution of the parameters leads to a number of infectious I(t f ) = 7.0 · 10 5 and a total number of infected cases (including recovered) (I + R)(t f ) = 2.0 · 10 6 at the end of the observation period (April 14). We obtained an effective reproduction number that was divided by a factor 7, compared to the estimate of the R 0 carried out in France at the early stage of the epidemic, before the country went into lockdown [a value R 0 = 3.2 was obtained in (15) ].
cord-275827-r86ygqmy	2020	In addition to this passive monitoring subject to under-reporting, other sources of information have been developed to improve vigilance: systematic data collection on falsified prescriptions from pharmacies ("ordonnances suspectes indicateur d''abus possible", OSIAP survey) [11, 12] and on secure prescription forms for narcotic drug prescriptions ( "antalgiques stupéfiants et ordonnances sécurisées", ASOS survey) [13] , systematic data collection from patients seen in addiction specialized structures ("observatoire des produits psychotropes illicites ou détournés de leur usage médicamenteux", OPPIDUM survey) [14] , analysis of toxicological data on chemical submission [15] or on deaths in a medico-legal framework ("décès en relation avec l''abus de médicaments et de substances", DRAMES survey) [16] . These early signals have been transmitted to national health authorities, leading to the implementation of a weekly specific monitoring of noteworthy cases or events related to the COVID-19, related to the lockdown, and of all falsified or abnormal prescription forms reported through the OSIAP survey during the period.
cord-282095-cbfyydi3	2020	
cord-284616-jgtsl06q	2020	A regulatory team headed by an anaesthesiologist with the help of surgeons, usually meeting once a week, decides a new organisation evaluating rapidly both management of critical negative and positive COVID-19 patients and surgical activity; chronological details are listed in Table 1 The man-power includes 40 anaesthetist nurses and RR nurses and 10 anaesthesiologists (2 anaesthesiologists present 24 hours a day). This radical reorganisation within 2 weeks of an operating theatre and a RR relies on the professional, structural and material resources of an anaesthesia department to create an ICU with 10 beds dedicated to critical COVID-19 infected patients while maintaining the management of selected scheduled and emergency surgery. We report our experience with mobilisation of an anaesthesia team and use of existing structures for urgent creation of an ICU managing critical COVID-19 patients in a pandemic which exceeds the usual resources of resuscitation structures.
cord-285187-1h5tjs0r	2020	PURPOSE: The purpose of the study was to describe epileptologists'' opinion on the increased use of remote systems implemented during the COVID-19 pandemic across clinics, education, and scientific meetings activities. Interestingly, before the COVID-19 pandemic, remote systems were significantly more frequently used in China for clinical activity compared with France or Italy. The aim of this study was to assess the impact of the COVID-19 pandemic on the acute use of remote systems in clinics, education, and scientific meetings in the field of epilepsy and to explore the users'' satisfaction and the perspectives of future use. We conducted a cross-sectional, electronic survey of epileptologists, neurologists, and pediatric neurologists mainly involved in the epilepsy field to determine the use of remote work during the COVID-19 pandemic (supplementary data). Before the COVID-19 pandemic, the rate of respondents who had experienced remote working systems was higher in China than in the two other countries (91.6% versus 61.7% for France and 25% for Italy, p = 10 −4 ).
cord-288079-rr8h5dgy	2020	title: Population modeling of early COVID-19 epidemic dynamics in French regions and estimation of the lockdown impact on infection rate Combining several French public datasets on the early dynamics of the epidemic, we estimate region-specific key parameters conditionally on this mechanistic model through Stochastic Approximation Expectation Maximization (SAEM) optimization using Monolix software. While traditional compartment models do not account for spatiality, we propose to take it into account by: i) modeling the epidemic at a finer, more homogeneous geographical scale (this is particularly important once lockdown is in place); ii) by using a population approach with random effects across French regions which allows each region to have relatively different dynamics while taking all information into account for the estimation of model parameters iii) aligning the initial starting time of the epidemic for all regions.
cord-292475-jrl1fowa	2020	
cord-296081-6coxz3l8	2020	
cord-299846-yx18oyv6	2020	The stochastic discrete version of Pandæsim showed very good correlations between the simulation results and the statistics gathered from hospitals, both on day by day and on global numbers, including the effects of the lockdown. The number of people of each age slice leaving their home sub-regions is a stochastic sample (or averaged value for the deterministic continuous solver) of a percentage of the population of this sub-region. Starting from an initial state (number of contagious people in each sub-region), the simulation algorithm iterates the following process at each timestep until either the epidemic ends or the maximum duration of the simulation is reached (defaults to 720 days). When the initial number of contagious people was relatively high, for example, in the Val-de-Marne sub-region (180), the results for both solvers were nearly identical: 5207 deaths for the average of 1000 stochastic runs and 5204 deaths for a deterministic run (Figures 2 and 3) .
cord-314884-110nqkej	2020	In the current study, we applied a Pearson correlation test to public health as well as weather data, in order to assess the linear relationship between COVID-19 mortality rate and the sunlight exposure. In the current study, we applied a Pearson correlation test to public health as well as weather data, in order to assess the linear relationship between COVID-19 mortality rate and the sunlight exposure. For instance in continental metropolitan France, average annual sunlight hours are significantly (for a p-value of 1.532x10 -32 ) correlated to the COVID-19 mortality rate, with a Pearson coefficient of -0.636. Specifically in the context of continental metropolitan France, the correlation between sunlight exposure and SARS-CoV-2 infection will be studied in this article, by using an adjusted Pearson test applied to public health and weather data [13] [14] [15] .
cord-318701-f9j13fsc	2020	On 12 March 2020, when WHO declared the status of a pandemic concerning the novel coronavirus (WHO 2020e), crisis measures were taken by the President of the French Republic (2020a) and his government, to control the epidemic and manage the health situation, namely, the closure of the nurseries, schools and universities for users as of 16 March 2020 ; the introduction of short-time work hours for employees whose companies cannot carry out their activities and of teleworking for all employees who have this possibility of adjusting the exercise of their profession (Ministry of Solidarity & Health 2020c). The health context made it possible to create the first telecare procedure related to the management of patients with COVID-19 by home nurses during the period of the state of health emergency (High Authority of Health 2020; Prime Minister of the French Government 2020c).
cord-319418-ao0df0q7	2020	
cord-320636-mvtux07x	2020	Using age-stratified transmission models parameterized to behavioral data and calibrated to regional hospital admissions, we estimated that 69,115 [58,072-77,449] COVID-19 symptomatic cases occurred, suggesting that 9 out of 10 cases with symptoms were not ascertained. In France, the surveillance strategy implemented by authorities to exit lockdown on May 11, 2020 was multifold 2,3 and based on an expanded case definition for COVID-19 suspect cases to guide clinical diagnosis 4 ; recommendations to the general population to seek healthcare even in presence of mild symptoms; prescription of diagnostic tests to suspect cases by general practitioners for systematic and comprehensive testing; isolation of confirmed cases and tracing of their contacts. Here we estimated the rate of detection of COVID-19 symptomatic cases in France in May-June 2020 after lockdown, through the use of virological and participatory syndromic surveillance data coupled with mathematical transmission models calibrated to regional hospitalizations.
cord-320773-zisujjsx	2020	It was particularly pronounced for intrusive policy measures, such as mobile data use for movement tracking, economic concerns, and trust in the information from the national government. In order to understand the public sentiment towards the COVID-19 containment measures and to inform future policy development, we collected information on people''s support for these policies, their worries in relation to the unfolding epidemic, and their trust in different sources of information. Overall, a north-south gradient could often be noticed in the EU regarding policy support: people living in the southern states (Portugal, Italy, and France) tended to approve of the containment policies more than residents in the northern countries (Denmark, Germany and the Netherlands). The first insights obtained from the data showed that containment and mitigating policies undertaken by national governments in response to the initial stages of the COVID-19 pandemic were generally wellreceived by the population in all countries covered by the survey.
cord-322943-lvdl7puw	2010	
cord-331509-p19dg1jw	2020	title: Porcine epidemic diarrhea virus: Viral RNA detection and quantification using a validated one-step real time RT-PCR In this study we described the development and validation of a SYBR™ Green one-step RT-qPCR according to the French norm NF U47-600, for the detection and quantification of PEDV viral RNA. Specificity and sensitivity, limit of detection (LoD), limit of quantification (LQ), linearity, intra and inter assay variability were evaluated using transcribed RNA and fecal and jejunum matrices spiked with virus. For a rapid, accurate and reliable diagnosis of PED in the veterinary laboratory, a method for the detection of PEDV viral RNA has been developed and more importantly validated according to the "Association Francaise de NORmalisation" (AFNOR) French NF U47-600 norm entitled "requirement and recommendation for the implementation, development and validation of PCR in animal health" (AFNOR, 2015a; AFNOR, 2015b) . This method should help harmonize detection and quantification of viral RNA from PEDV belonging to both S-non-INDEL and S-INDEL strains in both field and experimental settings.
cord-335215-h9p4kmss	2011	
cord-335252-med3c01q	2020	L''objectif de cet article est de décrire la réorganisation des soins psychiatriques en milieu pénitentiaire en contexte de pandémie de Covid-19 et d''interroger les conséquences du confinement et des libérations anticipées sur la santé mentale des personnes détenues. L''objectif de cet article est de décrire la réorganisation des soins psychiatriques en milieu pénitentiaire en contexte de pandémie de Covid-19 et d''interroger les conséquences du confinement et des libérations anticipées sur la santé mentale des personnes détenues. L''épidémie de Covid-19 semble avoir été plutôt contenue dans les prisons françaises au cours de la période de confinement mais le poids des mesures mises en place sur la population carcérale est important. L''épidémie de Covid-19 semble avoir été plutôt contenue dans les prisons françaises au cours de la période de confinement mais le poids des mesures mises en place sur la population carcérale est important.
cord-335297-vxhta6a4	2018	Cases in dogs were reported in association with intestinal lymphangiectasia (Peterson, 1996) , mediastinal lymphangiosarcoma (Myers et al., 1966) , acute pancreatitis (Lott et al., 2015) , abdominal lymphatic rupture (Fossum et al., 1992) , complication of mesenteric lymphangiography for chylothorax (Fossum et al., 1992) , and lymphatic obstruction secondary to thrombus formation (Fossum et al., 1992) . A case of chylous pleural and peritoneal effusion with no underlying cause was described in a cat, with no postmortem examination performed (Thompson and Carr, 2002) . (2013) previously reported 34 feline cases of pancreatic carcinoma; chylous ascites was present in one cat in this series. By analogy, rutin has been unsuccessfully used in a case of chyloabdomen secondary to hypertrophic cardiomyopathy and a chylous pleural and peritoneal effusion with no underlying condition (Nelson, 2001; Thompson and Carr, 2002) .
cord-337744-g17qe8fi	2020	Lockdown caused a 65% reduction in countrywide number of displacements, and was particularly effective in reducing work-related short-range mobility, especially during rush hours, and recreational long-range trips. Accurately measuring changes in human mobility under these restrictions is essential to (i) quantitatively determine how imposed measures and recommendations (e.g. regarding telework where possible, ban of leisure trips) translated into reduced mobility at specific scales and times, (ii) inform models estimating the effectiveness of the ongoing lockdown in reducing the epidemic spread 3,4 , (iii) help devising social distancing measures needed for the post-lockdown phase. The impact of nationwide lockdown in the reduction of outgoing mobility per region was strongly associated with the fraction of the population in the most active age range (24-59 y.o.) 24 (Pearson r = 0.91, p < 0.01) and the fraction of workers employed in sectors that substantially modified their organization during lockdown, due to telework, partial or full closure of activities (Pearson r = 0.80, p < 0.01) (Table 1 and Figure 4) .
cord-339820-x8r27w14	2020	50 Based on regional model analysis before and after the lockdown, we present a network model to characterize the pandemic transmission between regions in France after lockdown and evaluate the transport effect of COVID-19 pandemic, when considering all age classes together. In this section, regional scales of France are considered and all age classes are summed to calibrate the parameters of the pandemic model (6)-(13) during 12 All rights reserved. In this section, the general form of an integro-differential model capable of integrating different age classes and areas is introduced to discuss the transport effect of COVID-19 in France after lockdown. . https://doi.org/10.1101/2020.07.27.20161430 doi: medRxiv preprint Equation (40) describes the network dynamics of COVID-19 pandemic after lockdown and the transport effect on different age class on the basis of the regional pandemic transmission dynamics during lockdown.
cord-340298-0l4pec0z	2020	title: Impact of virus testing on COVID-19 case fatality rate: estimate using a fixed-effects model Methods We use data on inpatients across French geographic areas and propose a novel methodology that exploits policy discontinuities at region borders to estimate the effect of COVID-19 tests on the case-fatality rate. Screening policies and mortality rate might be related to the fact that testing allows authorities to detect and isolate infected people and to prevent them from transmitting the virus; and also enables early treatment, thus increasing the chances of cure. We used a fixed-effects model to assess the impact of the number of tests performed over time at a local geographical level (department) on fatality-cases. Our strategy consisted in comparing all contiguous department pairs sharing a region border (See Figure 1 for an example) to identify the effect of testing on the case fatality rate.
cord-344020-8poerd09	2020	We report dengue virus (DENV) infection in two Dutch tourists who visited Département Var, southern France, in July and August 2020. We report dengue virus (DENV) infection in two Dutch tourists who visited Département Var, southern France, in July and August 2020. As some autochthonous dengue cases have occurred in Europe in recent years, awareness among physicians and public health experts about possible intermittent presence of DENV in southern Europe is important to minimise delay in diagnosis and treatment. As some autochthonous dengue cases have occurred in Europe in recent years, awareness among physicians and public health experts about possible intermittent presence of DENV in southern Europe is important to minimise delay in diagnosis and treatment. On August 27, upon confirmation of the serological results, Patient 1 was reported by the RIVM to the French authorities through the Early Warning and Response System of the European Union as an autochthonous DENV infection probably acquired in France with cross-border implication.
cord-344984-mg779mix	2009	
cord-347244-abxv2mkz	2012	
cord-350571-6tapkjb6	2017	Possible solutions might be to use shared communication tools like Internet based communication programs and to introduce the patient as a participant at the IMRs. Please specify your abstract type: Research abstract Background and objective: International good pharmacy practice guidelines describe how pharmacists should counsel the patients about their medicines, offer additional services where needed, and intervene at drug related problems. Please specify your abstract type: Descriptive abstract (for projects) Background and objective: In order to improve the medication reconciliation and to implement training programs for the medical team in an associated to general hospital nursing (ASNH) home we measured the discrepancies between pharmacy registered treatments (PRT) and medical prescriptions (MP), and we analysed potentially inappropriate prescriptions according to ''''American Geriatrics Society 2015 Beers Criteria'''' and ''''STOPP-START 2014 criteria.
cord-355038-o2hr5mox	2020	Conclusion: In patients with moderate-to-severe ARDS, a higher tidal volume under PSV within the 72 h following neuromuscular blockers cessation is independently associated with the 28-day mortality.Compliance with ethics regulations: Yes. Kaplan-Meier estimate of the cumulative probability of survival according to the mean tidal volume (Vt)-lower of higher than 8 ml/ kg-under pressure support ventilation (PSV) during the "transition period" transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical setting. Compliance with ethics regulations: Yes. Patients and methods: In a retrospective monocentric study (01/2013-01/2017) conducted in cardio-vascular surgical intensive care unit (ICU) in Henri Mondor teaching hospital, all consecutive adult patients who underwent peripheral VA-ECMO were included, with exclusion of those dying in the first 24 h. Compliance with ethics regulations: Yes. Rationale: Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients and the need for invasive mechanical ventilation has become a major clinical end-point in randomized controlled trials (RCT).
cord-355549-6xnjj5h5	2020	The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. The aim of this first report from the French REIN registry is to describe the population of infected dialysis patients and their course of illness, estimate the incidence and lethality of COVID-19 disease and identify the risk factors associated with the probability of death. This can also be associated with the implementation of all the necessary preventive actions prone by the SFNDT, including 1/wearing a mask during transport and for the entire period of care, 2/systematic tracking of patients and screening at the entrance to dialysis units based on fever and symptoms or contact with an infected person and 3/restricting areas for COVID-19 cases (18),.