id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291858-e0s3o2r4	Tekes, G.	Feline Coronaviruses: Pathogenesis of Feline Infectious Peritonitis	2016-08-31		.txt	text/plain	9229	481	48	Feline infectious peritonitis (FIP) belongs to the few animal virus diseases in which, in the course of a generally harmless persistent infection, a virus acquires a small number of mutations that fundamentally change its pathogenicity, invariably resulting in a fatal outcome. We discuss the recent progress in the development of FCoV reverse genetics systems suitable to generate recombinant field viruses containing appropriate mutations for in vivo studies. Deletions of the entire FCoV ORF 3 and 7 genome regions showed that the accessory genes are dispensable for viral growth in vitro; they were suggested to be important for virus replication and virulence in vivo (Haijema et al., 2004) . According to pathogenicity, FCoVs are separated into two biotypes that are generally referred to as feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV). Molecular characterization of feline infectious peritonitis virus strain DF-2 and studies of the role of ORF3abc in viral cell tropism	./cache/cord-291858-e0s3o2r4.txt	./txt/cord-291858-e0s3o2r4.txt