id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255873-18zmvlmk	Wang, Jinshan	Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor	2014-11-14		.txt	text/plain	1519	93	57	title: Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor In this study, the main protease of FIPV in complex with a Michael acceptor-type inhibitor was crystallized. The complex crystals diffracted to 2.5 Å resolution and belonged to space group I422, with unit-cell parameters a = 112.3, b = 112.3, c = 102.1 Å. On the other hand, FIPV efficiently replicates in macrophages/monocytes, leading to feline infectious peritonitis (FIP), a highly lethal systemic granulomatous disease of wild and domestic cats (Addie et al., 2009; Pedersen, 2009; Balint, Farsang, Szeredi et al., 2014; Kipar & Meli, 2014) . Isopropyl -d-1-thiogalactopyranoside was then added to a final concentration of 0.5 mM and the cultures were induced to express FIPV main protease at 289 K for 16 h. A typical diffraction pattern of an FIPV main protease complex crystal collected on beamline BL17U of the Shanghai Synchrotron Radiation Facility (SSRF).	./cache/cord-255873-18zmvlmk.txt	./txt/cord-255873-18zmvlmk.txt