id sid tid token lemma pos cord-285335-agm4zbcx 1 1 key key JJ cord-285335-agm4zbcx 1 2 : : : cord-285335-agm4zbcx 1 3 cord-285335-agm4zbcx cord-285335-agm4zbcx NNS cord-285335-agm4zbcx 1 4 authors author NNS cord-285335-agm4zbcx 1 5 : : : cord-285335-agm4zbcx 1 6 Kennedy Kennedy NNP cord-285335-agm4zbcx 1 7 , , , cord-285335-agm4zbcx 1 8 Melissa Melissa NNP cord-285335-agm4zbcx 1 9 ; ; : cord-285335-agm4zbcx 1 10 Boedeker Boedeker NNP cord-285335-agm4zbcx 1 11 , , , cord-285335-agm4zbcx 1 12 Nancy Nancy NNP cord-285335-agm4zbcx 1 13 ; ; : cord-285335-agm4zbcx 1 14 Gibbs Gibbs NNP cord-285335-agm4zbcx 1 15 , , , cord-285335-agm4zbcx 1 16 Pam Pam NNP cord-285335-agm4zbcx 1 17 ; ; : cord-285335-agm4zbcx 1 18 Kania Kania NNP cord-285335-agm4zbcx 1 19 , , , cord-285335-agm4zbcx 2 1 Stephen Stephen NNP cord-285335-agm4zbcx 2 2 title title NN cord-285335-agm4zbcx 2 3 : : : cord-285335-agm4zbcx 2 4 Deletions deletion NNS cord-285335-agm4zbcx 2 5 in in IN cord-285335-agm4zbcx 2 6 the the DT cord-285335-agm4zbcx 2 7 7a 7a NN cord-285335-agm4zbcx 2 8 ORF ORF NNP cord-285335-agm4zbcx 2 9 of of IN cord-285335-agm4zbcx 2 10 feline feline JJ cord-285335-agm4zbcx 2 11 coronavirus coronavirus NN cord-285335-agm4zbcx 2 12 associated associate VBN cord-285335-agm4zbcx 2 13 with with IN cord-285335-agm4zbcx 2 14 an an DT cord-285335-agm4zbcx 2 15 epidemic epidemic NN cord-285335-agm4zbcx 2 16 of of IN cord-285335-agm4zbcx 2 17 feline feline JJ cord-285335-agm4zbcx 2 18 infectious infectious JJ cord-285335-agm4zbcx 2 19 peritonitis peritonitis NN cord-285335-agm4zbcx 2 20 date date NN cord-285335-agm4zbcx 2 21 : : : cord-285335-agm4zbcx 2 22 2001 2001 CD cord-285335-agm4zbcx 2 23 - - HYPH cord-285335-agm4zbcx 2 24 08 08 CD cord-285335-agm4zbcx 2 25 - - HYPH cord-285335-agm4zbcx 2 26 08 08 CD cord-285335-agm4zbcx 2 27 journal journal NN cord-285335-agm4zbcx 2 28 : : : cord-285335-agm4zbcx 3 1 Vet Vet NNP cord-285335-agm4zbcx 3 2 Microbiol Microbiol NNP cord-285335-agm4zbcx 3 3 DOI DOI NNP cord-285335-agm4zbcx 3 4 : : : cord-285335-agm4zbcx 3 5 10.1016 10.1016 CD cord-285335-agm4zbcx 3 6 / / SYM cord-285335-agm4zbcx 3 7 s0378 s0378 NNP cord-285335-agm4zbcx 3 8 - - HYPH cord-285335-agm4zbcx 3 9 1135(01)00354 1135(01)00354 NNP cord-285335-agm4zbcx 3 10 - - HYPH cord-285335-agm4zbcx 3 11 6 6 CD cord-285335-agm4zbcx 3 12 sha sha NN cord-285335-agm4zbcx 3 13 : : : cord-285335-agm4zbcx 3 14 d5d6e84c687eed1364f3489d04e9d76f3d99770a d5d6e84c687eed1364f3489d04e9d76f3d99770a NNP cord-285335-agm4zbcx 3 15 doc_id doc_id CD cord-285335-agm4zbcx 3 16 : : : cord-285335-agm4zbcx 3 17 285335 285335 CD cord-285335-agm4zbcx 3 18 cord_uid cord_uid NNS cord-285335-agm4zbcx 3 19 : : : cord-285335-agm4zbcx 4 1 agm4zbcx agm4zbcx NFP cord-285335-agm4zbcx 4 2 A a DT cord-285335-agm4zbcx 4 3 population population NN cord-285335-agm4zbcx 4 4 of of IN cord-285335-agm4zbcx 4 5 Persian persian JJ cord-285335-agm4zbcx 4 6 cats cat NNS cord-285335-agm4zbcx 4 7 experienced experience VBD cord-285335-agm4zbcx 4 8 an an DT cord-285335-agm4zbcx 4 9 epidemic epidemic NN cord-285335-agm4zbcx 4 10 of of IN cord-285335-agm4zbcx 4 11 feline feline JJ cord-285335-agm4zbcx 4 12 infectious infectious JJ cord-285335-agm4zbcx 4 13 peritonitis peritonitis NN cord-285335-agm4zbcx 4 14 ( ( -LRB- cord-285335-agm4zbcx 4 15 FIP FIP NNP cord-285335-agm4zbcx 4 16 ) ) -RRB- cord-285335-agm4zbcx 4 17 over over IN cord-285335-agm4zbcx 4 18 2 2 CD cord-285335-agm4zbcx 4 19 years year NNS cord-285335-agm4zbcx 4 20 . . . cord-285335-agm4zbcx 5 1 Twelve twelve CD cord-285335-agm4zbcx 5 2 cases case NNS cord-285335-agm4zbcx 5 3 of of IN cord-285335-agm4zbcx 5 4 FIP FIP NNP cord-285335-agm4zbcx 5 5 occurred occur VBD cord-285335-agm4zbcx 5 6 in in IN cord-285335-agm4zbcx 5 7 litters litter NNS cord-285335-agm4zbcx 5 8 born bear VBN cord-285335-agm4zbcx 5 9 during during IN cord-285335-agm4zbcx 5 10 this this DT cord-285335-agm4zbcx 5 11 period period NN cord-285335-agm4zbcx 5 12 . . . cord-285335-agm4zbcx 6 1 Cats cat NNS cord-285335-agm4zbcx 6 2 contracting contract VBG cord-285335-agm4zbcx 6 3 FIP FIP NNP cord-285335-agm4zbcx 6 4 were be VBD cord-285335-agm4zbcx 6 5 all all DT cord-285335-agm4zbcx 6 6 genetically genetically RB cord-285335-agm4zbcx 6 7 related relate VBN cord-285335-agm4zbcx 6 8 through through IN cord-285335-agm4zbcx 6 9 the the DT cord-285335-agm4zbcx 6 10 sire sire NN cord-285335-agm4zbcx 6 11 . . . cord-285335-agm4zbcx 7 1 Feline feline JJ cord-285335-agm4zbcx 7 2 coronavirus coronavirus NN cord-285335-agm4zbcx 8 1 ( ( -LRB- cord-285335-agm4zbcx 8 2 FCoV FCoV NNP cord-285335-agm4zbcx 8 3 ) ) -RRB- cord-285335-agm4zbcx 8 4 genomic genomic JJ cord-285335-agm4zbcx 8 5 RNA RNA NNP cord-285335-agm4zbcx 8 6 was be VBD cord-285335-agm4zbcx 8 7 detected detect VBN cord-285335-agm4zbcx 8 8 consistently consistently RB cord-285335-agm4zbcx 8 9 in in IN cord-285335-agm4zbcx 8 10 this this DT cord-285335-agm4zbcx 8 11 study study NN cord-285335-agm4zbcx 8 12 in in IN cord-285335-agm4zbcx 8 13 biologic biologic JJ cord-285335-agm4zbcx 8 14 samples sample NNS cord-285335-agm4zbcx 8 15 from from IN cord-285335-agm4zbcx 8 16 adult adult NN cord-285335-agm4zbcx 8 17 cats cat NNS cord-285335-agm4zbcx 8 18 , , , cord-285335-agm4zbcx 8 19 kittens kitten NNS cord-285335-agm4zbcx 8 20 suffering suffer VBG cord-285335-agm4zbcx 8 21 from from IN cord-285335-agm4zbcx 8 22 FIP FIP NNP cord-285335-agm4zbcx 8 23 , , , cord-285335-agm4zbcx 8 24 and and CC cord-285335-agm4zbcx 8 25 their -PRON- PRP$ cord-285335-agm4zbcx 8 26 siblings sibling NNS cord-285335-agm4zbcx 8 27 . . . cord-285335-agm4zbcx 9 1 Analysis analysis NN cord-285335-agm4zbcx 9 2 of of IN cord-285335-agm4zbcx 9 3 viral viral JJ cord-285335-agm4zbcx 9 4 7a/7b 7a/7b CD cord-285335-agm4zbcx 9 5 open open JJ cord-285335-agm4zbcx 9 6 reading reading NN cord-285335-agm4zbcx 9 7 frame frame NN cord-285335-agm4zbcx 9 8 ( ( -LRB- cord-285335-agm4zbcx 9 9 ORFs ORFs NNP cord-285335-agm4zbcx 9 10 ) ) -RRB- cord-285335-agm4zbcx 9 11 were be VBD cord-285335-agm4zbcx 9 12 analyzed analyze VBN cord-285335-agm4zbcx 9 13 and and CC cord-285335-agm4zbcx 9 14 revealed reveal VBD cord-285335-agm4zbcx 9 15 two two CD cord-285335-agm4zbcx 9 16 distinct distinct JJ cord-285335-agm4zbcx 9 17 virus virus NN cord-285335-agm4zbcx 9 18 variants variant NNS cord-285335-agm4zbcx 9 19 circulating circulate VBG cord-285335-agm4zbcx 9 20 in in IN cord-285335-agm4zbcx 9 21 the the DT cord-285335-agm4zbcx 9 22 population population NN cord-285335-agm4zbcx 9 23 , , , cord-285335-agm4zbcx 9 24 one one CD cord-285335-agm4zbcx 9 25 with with IN cord-285335-agm4zbcx 9 26 an an DT cord-285335-agm4zbcx 9 27 intact intact JJ cord-285335-agm4zbcx 9 28 7a 7a NN cord-285335-agm4zbcx 9 29 ORF ORF NNP cord-285335-agm4zbcx 9 30 and and CC cord-285335-agm4zbcx 9 31 one one CD cord-285335-agm4zbcx 9 32 with with IN cord-285335-agm4zbcx 9 33 two two CD cord-285335-agm4zbcx 9 34 major major JJ cord-285335-agm4zbcx 9 35 deletions deletion NNS cord-285335-agm4zbcx 9 36 in in IN cord-285335-agm4zbcx 9 37 the the DT cord-285335-agm4zbcx 9 38 7a 7a NN cord-285335-agm4zbcx 9 39 ORF ORF NNP cord-285335-agm4zbcx 9 40 . . . cord-285335-agm4zbcx 10 1 The the DT cord-285335-agm4zbcx 10 2 7b 7b NNS cord-285335-agm4zbcx 10 3 ORFs ORFs NNP cord-285335-agm4zbcx 10 4 were be VBD cord-285335-agm4zbcx 10 5 intact intact JJ cord-285335-agm4zbcx 10 6 and and CC cord-285335-agm4zbcx 10 7 similar similar JJ cord-285335-agm4zbcx 10 8 among among IN cord-285335-agm4zbcx 10 9 all all DT cord-285335-agm4zbcx 10 10 virus virus NN cord-285335-agm4zbcx 10 11 isolates isolate NNS cord-285335-agm4zbcx 10 12 , , , cord-285335-agm4zbcx 10 13 although although IN cord-285335-agm4zbcx 10 14 point point NN cord-285335-agm4zbcx 10 15 mutations mutation NNS cord-285335-agm4zbcx 10 16 resulting result VBG cord-285335-agm4zbcx 10 17 in in IN cord-285335-agm4zbcx 10 18 amino amino NN cord-285335-agm4zbcx 10 19 acid acid NN cord-285335-agm4zbcx 10 20 changes change NNS cord-285335-agm4zbcx 10 21 were be VBD cord-285335-agm4zbcx 10 22 present present JJ cord-285335-agm4zbcx 10 23 . . . cord-285335-agm4zbcx 11 1 The the DT cord-285335-agm4zbcx 11 2 sire sire NN cord-285335-agm4zbcx 11 3 was be VBD cord-285335-agm4zbcx 11 4 determined determine VBN cord-285335-agm4zbcx 11 5 to to TO cord-285335-agm4zbcx 11 6 be be VB cord-285335-agm4zbcx 11 7 infected infect VBN cord-285335-agm4zbcx 11 8 with with IN cord-285335-agm4zbcx 11 9 both both DT cord-285335-agm4zbcx 11 10 variants variant NNS cord-285335-agm4zbcx 11 11 , , , cord-285335-agm4zbcx 11 12 and and CC cord-285335-agm4zbcx 11 13 was be VBD cord-285335-agm4zbcx 11 14 persistently persistently RB cord-285335-agm4zbcx 11 15 virus virus NN cord-285335-agm4zbcx 11 16 - - HYPH cord-285335-agm4zbcx 11 17 infected infect VBN cord-285335-agm4zbcx 11 18 . . . cord-285335-agm4zbcx 12 1 We -PRON- PRP cord-285335-agm4zbcx 12 2 speculate speculate VBP cord-285335-agm4zbcx 12 3 the the DT cord-285335-agm4zbcx 12 4 deletion deletion NN cord-285335-agm4zbcx 12 5 variant variant NN cord-285335-agm4zbcx 12 6 arose arise VBD cord-285335-agm4zbcx 12 7 from from IN cord-285335-agm4zbcx 12 8 the the DT cord-285335-agm4zbcx 12 9 non non JJ cord-285335-agm4zbcx 12 10 - - JJ cord-285335-agm4zbcx 12 11 deletion deletion JJ cord-285335-agm4zbcx 12 12 variant variant NN cord-285335-agm4zbcx 12 13 during during IN cord-285335-agm4zbcx 12 14 viral viral JJ cord-285335-agm4zbcx 12 15 replication replication NN cord-285335-agm4zbcx 12 16 in in IN cord-285335-agm4zbcx 12 17 this this DT cord-285335-agm4zbcx 12 18 population population NN cord-285335-agm4zbcx 12 19 , , , cord-285335-agm4zbcx 12 20 possibly possibly RB cord-285335-agm4zbcx 12 21 in in IN cord-285335-agm4zbcx 12 22 the the DT cord-285335-agm4zbcx 12 23 sire sire NN cord-285335-agm4zbcx 12 24 . . . cord-285335-agm4zbcx 13 1 Feline feline JJ cord-285335-agm4zbcx 13 2 infectious infectious JJ cord-285335-agm4zbcx 13 3 peritonitis peritonitis NN cord-285335-agm4zbcx 13 4 ( ( -LRB- cord-285335-agm4zbcx 13 5 FIP FIP NNP cord-285335-agm4zbcx 13 6 ) ) -RRB- cord-285335-agm4zbcx 13 7 is be VBZ cord-285335-agm4zbcx 13 8 a a DT cord-285335-agm4zbcx 13 9 serious serious JJ cord-285335-agm4zbcx 13 10 disease disease NN cord-285335-agm4zbcx 13 11 of of IN cord-285335-agm4zbcx 13 12 domestic domestic JJ cord-285335-agm4zbcx 13 13 and and CC cord-285335-agm4zbcx 13 14 wild wild JJ cord-285335-agm4zbcx 13 15 Felidae Felidae NNP cord-285335-agm4zbcx 13 16 . . . cord-285335-agm4zbcx 14 1 It -PRON- PRP cord-285335-agm4zbcx 14 2 is be VBZ cord-285335-agm4zbcx 14 3 an an DT cord-285335-agm4zbcx 14 4 important important JJ cord-285335-agm4zbcx 14 5 disease disease NN cord-285335-agm4zbcx 14 6 of of IN cord-285335-agm4zbcx 14 7 cats cat NNS cord-285335-agm4zbcx 14 8 in in IN cord-285335-agm4zbcx 14 9 multi multi JJ cord-285335-agm4zbcx 14 10 - - JJ cord-285335-agm4zbcx 14 11 cat cat JJ cord-285335-agm4zbcx 14 12 households household NNS cord-285335-agm4zbcx 14 13 , , , cord-285335-agm4zbcx 14 14 catteries catterie NNS cord-285335-agm4zbcx 14 15 , , , cord-285335-agm4zbcx 14 16 and and CC cord-285335-agm4zbcx 14 17 shelters shelter NNS cord-285335-agm4zbcx 14 18 ( ( -LRB- cord-285335-agm4zbcx 15 1 Scott Scott NNP cord-285335-agm4zbcx 15 2 et et NNP cord-285335-agm4zbcx 15 3 al al NNP cord-285335-agm4zbcx 15 4 . . NNP cord-285335-agm4zbcx 15 5 , , , cord-285335-agm4zbcx 15 6 1992 1992 CD cord-285335-agm4zbcx 15 7 ; ; . cord-285335-agm4zbcx 16 1 Wolf Wolf NNP cord-285335-agm4zbcx 16 2 , , , cord-285335-agm4zbcx 16 3 1995 1995 CD cord-285335-agm4zbcx 16 4 ) ) -RRB- cord-285335-agm4zbcx 16 5 . . . cord-285335-agm4zbcx 17 1 This this DT cord-285335-agm4zbcx 17 2 disease disease NN cord-285335-agm4zbcx 17 3 can can MD cord-285335-agm4zbcx 17 4 manifest manifest VB cord-285335-agm4zbcx 17 5 as as IN cord-285335-agm4zbcx 17 6 an an DT cord-285335-agm4zbcx 17 7 effusive effusive JJ cord-285335-agm4zbcx 17 8 peritonitis peritonitis NN cord-285335-agm4zbcx 17 9 and/or and/or CC cord-285335-agm4zbcx 17 10 pleuritis pleuritis VB cord-285335-agm4zbcx 17 11 with with IN cord-285335-agm4zbcx 17 12 a a DT cord-285335-agm4zbcx 17 13 short short JJ cord-285335-agm4zbcx 17 14 course course NN cord-285335-agm4zbcx 17 15 ending end VBG cord-285335-agm4zbcx 17 16 in in IN cord-285335-agm4zbcx 17 17 death death NN cord-285335-agm4zbcx 17 18 ; ; : cord-285335-agm4zbcx 17 19 or or CC cord-285335-agm4zbcx 17 20 it -PRON- PRP cord-285335-agm4zbcx 17 21 may may MD cord-285335-agm4zbcx 17 22 present present VB cord-285335-agm4zbcx 17 23 as as IN cord-285335-agm4zbcx 17 24 a a DT cord-285335-agm4zbcx 17 25 more more RBR cord-285335-agm4zbcx 17 26 insidious insidious JJ cord-285335-agm4zbcx 17 27 disease disease NN cord-285335-agm4zbcx 17 28 with with IN cord-285335-agm4zbcx 17 29 Veterinary Veterinary NNP cord-285335-agm4zbcx 17 30 Microbiology Microbiology NNP cord-285335-agm4zbcx 17 31 81 81 CD cord-285335-agm4zbcx 17 32 ( ( -LRB- cord-285335-agm4zbcx 17 33 2001 2001 CD cord-285335-agm4zbcx 17 34 ) ) -RRB- cord-285335-agm4zbcx 17 35 [ [ -LRB- cord-285335-agm4zbcx 17 36 227 227 CD cord-285335-agm4zbcx 17 37 ] ] -RRB- cord-285335-agm4zbcx 17 38 [ [ -LRB- cord-285335-agm4zbcx 17 39 228 228 CD cord-285335-agm4zbcx 17 40 ] ] -RRB- cord-285335-agm4zbcx 17 41 [ [ -LRB- cord-285335-agm4zbcx 17 42 229 229 CD cord-285335-agm4zbcx 17 43 ] ] -RRB- cord-285335-agm4zbcx 17 44 [ [ -LRB- cord-285335-agm4zbcx 17 45 230 230 CD cord-285335-agm4zbcx 17 46 ] ] -RRB- cord-285335-agm4zbcx 17 47 [ [ -LRB- cord-285335-agm4zbcx 17 48 231 231 CD cord-285335-agm4zbcx 17 49 ] ] -RRB- cord-285335-agm4zbcx 17 50 [ [ -LRB- cord-285335-agm4zbcx 17 51 232 232 CD cord-285335-agm4zbcx 17 52 ] ] -RRB- cord-285335-agm4zbcx 17 53 [ [ -LRB- cord-285335-agm4zbcx 17 54 233 233 CD cord-285335-agm4zbcx 17 55 ] ] -RRB- cord-285335-agm4zbcx 17 56 [ [ -LRB- cord-285335-agm4zbcx 17 57 234 234 CD cord-285335-agm4zbcx 17 58 ] ] -RRB- cord-285335-agm4zbcx 17 59 granulomatous granulomatous JJ cord-285335-agm4zbcx 17 60 lesions lesion NNS cord-285335-agm4zbcx 17 61 affecting affect VBG cord-285335-agm4zbcx 17 62 multiple multiple JJ cord-285335-agm4zbcx 17 63 organs organ NNS cord-285335-agm4zbcx 17 64 that that WDT cord-285335-agm4zbcx 17 65 also also RB cord-285335-agm4zbcx 17 66 progresses progress VBZ cord-285335-agm4zbcx 17 67 to to IN cord-285335-agm4zbcx 17 68 death death NN cord-285335-agm4zbcx 17 69 ( ( -LRB- cord-285335-agm4zbcx 17 70 Pedersen Pedersen NNP cord-285335-agm4zbcx 17 71 , , , cord-285335-agm4zbcx 17 72 1987 1987 CD cord-285335-agm4zbcx 17 73 ; ; : cord-285335-agm4zbcx 17 74 Hoskins Hoskins NNP cord-285335-agm4zbcx 17 75 , , , cord-285335-agm4zbcx 17 76 1993 1993 CD cord-285335-agm4zbcx 17 77 ; ; : cord-285335-agm4zbcx 17 78 Pedersen Pedersen NNP cord-285335-agm4zbcx 17 79 , , , cord-285335-agm4zbcx 17 80 1995 1995 CD cord-285335-agm4zbcx 17 81 ) ) -RRB- cord-285335-agm4zbcx 17 82 . . . cord-285335-agm4zbcx 18 1 The the DT cord-285335-agm4zbcx 18 2 etiologic etiologic JJ cord-285335-agm4zbcx 18 3 agent agent NN cord-285335-agm4zbcx 18 4 of of IN cord-285335-agm4zbcx 18 5 FIP FIP NNP cord-285335-agm4zbcx 18 6 is be VBZ cord-285335-agm4zbcx 18 7 feline feline JJ cord-285335-agm4zbcx 18 8 coronavirus coronavirus NN cord-285335-agm4zbcx 18 9 ( ( -LRB- cord-285335-agm4zbcx 18 10 FCoV FCoV NNP cord-285335-agm4zbcx 18 11 ) ) -RRB- cord-285335-agm4zbcx 18 12 . . . cord-285335-agm4zbcx 19 1 In in IN cord-285335-agm4zbcx 19 2 environments environment NNS cord-285335-agm4zbcx 19 3 where where WRB cord-285335-agm4zbcx 19 4 large large JJ cord-285335-agm4zbcx 19 5 numbers number NNS cord-285335-agm4zbcx 19 6 of of IN cord-285335-agm4zbcx 19 7 cats cat NNS cord-285335-agm4zbcx 19 8 are be VBP cord-285335-agm4zbcx 19 9 housed house VBN cord-285335-agm4zbcx 19 10 closely closely RB cord-285335-agm4zbcx 19 11 together together RB cord-285335-agm4zbcx 19 12 , , , cord-285335-agm4zbcx 19 13 75 75 CD cord-285335-agm4zbcx 19 14 - - SYM cord-285335-agm4zbcx 19 15 100 100 CD cord-285335-agm4zbcx 19 16 % % NN cord-285335-agm4zbcx 19 17 of of IN cord-285335-agm4zbcx 19 18 the the DT cord-285335-agm4zbcx 19 19 animals animal NNS cord-285335-agm4zbcx 19 20 may may MD cord-285335-agm4zbcx 19 21 be be VB cord-285335-agm4zbcx 19 22 seropositive seropositive JJ cord-285335-agm4zbcx 19 23 to to IN cord-285335-agm4zbcx 19 24 the the DT cord-285335-agm4zbcx 19 25 virus virus NN cord-285335-agm4zbcx 19 26 ( ( -LRB- cord-285335-agm4zbcx 19 27 Pedersen Pedersen NNP cord-285335-agm4zbcx 19 28 , , , cord-285335-agm4zbcx 19 29 1995 1995 CD cord-285335-agm4zbcx 19 30 ) ) -RRB- cord-285335-agm4zbcx 19 31 . . . cord-285335-agm4zbcx 20 1 Despite despite IN cord-285335-agm4zbcx 20 2 these these DT cord-285335-agm4zbcx 20 3 numbers number NNS cord-285335-agm4zbcx 20 4 , , , cord-285335-agm4zbcx 20 5 FIP fip NN cord-285335-agm4zbcx 20 6 occurs occur VBZ cord-285335-agm4zbcx 20 7 sporadically sporadically RB cord-285335-agm4zbcx 21 1 -fatal -fatal JJ cord-285335-agm4zbcx 21 2 disease disease NN cord-285335-agm4zbcx 21 3 is be VBZ cord-285335-agm4zbcx 21 4 an an DT cord-285335-agm4zbcx 21 5 uncommon uncommon JJ cord-285335-agm4zbcx 21 6 manifestation manifestation NN cord-285335-agm4zbcx 21 7 of of IN cord-285335-agm4zbcx 21 8 infection infection NN cord-285335-agm4zbcx 21 9 with with IN cord-285335-agm4zbcx 21 10 FCoV. FCoV. NNP cord-285335-agm4zbcx 21 11 Virus virus NN cord-285335-agm4zbcx 21 12 factors factor NNS cord-285335-agm4zbcx 21 13 are be VBP cord-285335-agm4zbcx 21 14 important important JJ cord-285335-agm4zbcx 21 15 to to IN cord-285335-agm4zbcx 21 16 disease disease NN cord-285335-agm4zbcx 21 17 development development NN cord-285335-agm4zbcx 21 18 , , , cord-285335-agm4zbcx 21 19 as as IN cord-285335-agm4zbcx 21 20 virus virus NN cord-285335-agm4zbcx 21 21 strains strain NNS cord-285335-agm4zbcx 21 22 vary vary VBP cord-285335-agm4zbcx 21 23 in in IN cord-285335-agm4zbcx 21 24 virulence virulence NN cord-285335-agm4zbcx 21 25 ( ( -LRB- cord-285335-agm4zbcx 21 26 Pedersen Pedersen NNP cord-285335-agm4zbcx 21 27 , , , cord-285335-agm4zbcx 21 28 1987 1987 CD cord-285335-agm4zbcx 21 29 ) ) -RRB- cord-285335-agm4zbcx 21 30 . . . cord-285335-agm4zbcx 22 1 Virulent virulent JJ cord-285335-agm4zbcx 22 2 FCoV FCoV NNP cord-285335-agm4zbcx 22 3 is be VBZ cord-285335-agm4zbcx 22 4 theorized theorize VBN cord-285335-agm4zbcx 22 5 to to TO cord-285335-agm4zbcx 22 6 arise arise VB cord-285335-agm4zbcx 22 7 from from IN cord-285335-agm4zbcx 22 8 mutation mutation NN cord-285335-agm4zbcx 22 9 of of IN cord-285335-agm4zbcx 22 10 the the DT cord-285335-agm4zbcx 22 11 infecting infect VBG cord-285335-agm4zbcx 22 12 FCoV FCoV NNP cord-285335-agm4zbcx 22 13 during during IN cord-285335-agm4zbcx 22 14 replication replication NN cord-285335-agm4zbcx 22 15 in in IN cord-285335-agm4zbcx 22 16 the the DT cord-285335-agm4zbcx 22 17 intestinal intestinal JJ cord-285335-agm4zbcx 22 18 tract tract NN cord-285335-agm4zbcx 22 19 of of IN cord-285335-agm4zbcx 22 20 infected infected JJ cord-285335-agm4zbcx 22 21 cats cat NNS cord-285335-agm4zbcx 22 22 ( ( -LRB- cord-285335-agm4zbcx 22 23 Poland Poland NNP cord-285335-agm4zbcx 22 24 et et NNP cord-285335-agm4zbcx 22 25 al al NNP cord-285335-agm4zbcx 22 26 . . NNP cord-285335-agm4zbcx 22 27 , , , cord-285335-agm4zbcx 22 28 1996 1996 CD cord-285335-agm4zbcx 22 29 ; ; : cord-285335-agm4zbcx 22 30 Vennema Vennema NNP cord-285335-agm4zbcx 22 31 et et FW cord-285335-agm4zbcx 22 32 al al NNP cord-285335-agm4zbcx 22 33 . . NNP cord-285335-agm4zbcx 22 34 , , , cord-285335-agm4zbcx 22 35 1998 1998 CD cord-285335-agm4zbcx 22 36 ) ) -RRB- cord-285335-agm4zbcx 22 37 . . . cord-285335-agm4zbcx 23 1 The the DT cord-285335-agm4zbcx 23 2 7b 7b CD cord-285335-agm4zbcx 23 3 open open JJ cord-285335-agm4zbcx 23 4 reading reading NN cord-285335-agm4zbcx 23 5 frame frame NN cord-285335-agm4zbcx 23 6 ( ( -LRB- cord-285335-agm4zbcx 23 7 ORF ORF NNP cord-285335-agm4zbcx 23 8 ) ) -RRB- cord-285335-agm4zbcx 23 9 , , , cord-285335-agm4zbcx 23 10 the the DT cord-285335-agm4zbcx 23 11 3 3 CD cord-285335-agm4zbcx 23 12 0 0 CD cord-285335-agm4zbcx 23 13 -most -most NN cord-285335-agm4zbcx 23 14 gene gene NN cord-285335-agm4zbcx 23 15 , , , cord-285335-agm4zbcx 23 16 has have VBZ cord-285335-agm4zbcx 23 17 been be VBN cord-285335-agm4zbcx 23 18 speculated speculate VBN cord-285335-agm4zbcx 23 19 to to TO cord-285335-agm4zbcx 23 20 have have VB cord-285335-agm4zbcx 23 21 a a DT cord-285335-agm4zbcx 23 22 role role NN cord-285335-agm4zbcx 23 23 in in IN cord-285335-agm4zbcx 23 24 virulence virulence NN cord-285335-agm4zbcx 23 25 , , , cord-285335-agm4zbcx 23 26 as as IN cord-285335-agm4zbcx 23 27 deletions deletion NNS cord-285335-agm4zbcx 23 28 in in IN cord-285335-agm4zbcx 23 29 this this DT cord-285335-agm4zbcx 23 30 region region NN cord-285335-agm4zbcx 23 31 lead lead VB cord-285335-agm4zbcx 23 32 to to IN cord-285335-agm4zbcx 23 33 decreased decrease VBN cord-285335-agm4zbcx 23 34 virulence virulence NN cord-285335-agm4zbcx 23 35 ( ( -LRB- cord-285335-agm4zbcx 23 36 Vennema Vennema NNP cord-285335-agm4zbcx 23 37 et et FW cord-285335-agm4zbcx 23 38 al al NNP cord-285335-agm4zbcx 23 39 . . . cord-285335-agm4zbcx 24 1 , , , cord-285335-agm4zbcx 24 2 1992 1992 CD cord-285335-agm4zbcx 24 3 ; ; : cord-285335-agm4zbcx 24 4 Herrewegh Herrewegh NNP cord-285335-agm4zbcx 24 5 et et NNP cord-285335-agm4zbcx 24 6 al al NNP cord-285335-agm4zbcx 24 7 . . NNP cord-285335-agm4zbcx 24 8 , , , cord-285335-agm4zbcx 24 9 1995 1995 CD cord-285335-agm4zbcx 24 10 ; ; : cord-285335-agm4zbcx 24 11 Vennema Vennema NNP cord-285335-agm4zbcx 24 12 et et FW cord-285335-agm4zbcx 24 13 al al NNP cord-285335-agm4zbcx 24 14 . . NNP cord-285335-agm4zbcx 24 15 , , , cord-285335-agm4zbcx 24 16 1998 1998 CD cord-285335-agm4zbcx 24 17 ) ) -RRB- cord-285335-agm4zbcx 24 18 . . . cord-285335-agm4zbcx 25 1 Despite despite IN cord-285335-agm4zbcx 25 2 this this DT cord-285335-agm4zbcx 25 3 data data NN cord-285335-agm4zbcx 25 4 , , , cord-285335-agm4zbcx 25 5 the the DT cord-285335-agm4zbcx 25 6 specific specific JJ cord-285335-agm4zbcx 25 7 virus virus NN cord-285335-agm4zbcx 25 8 and and CC cord-285335-agm4zbcx 25 9 host host NN cord-285335-agm4zbcx 25 10 factors factor NNS cord-285335-agm4zbcx 25 11 involved involve VBN cord-285335-agm4zbcx 25 12 in in IN cord-285335-agm4zbcx 25 13 the the DT cord-285335-agm4zbcx 25 14 production production NN cord-285335-agm4zbcx 25 15 of of IN cord-285335-agm4zbcx 25 16 lethal lethal JJ cord-285335-agm4zbcx 25 17 disease disease NN cord-285335-agm4zbcx 25 18 are be VBP cord-285335-agm4zbcx 25 19 not not RB cord-285335-agm4zbcx 25 20 known know VBN cord-285335-agm4zbcx 25 21 . . . cord-285335-agm4zbcx 26 1 The the DT cord-285335-agm4zbcx 26 2 occurrence occurrence NN cord-285335-agm4zbcx 26 3 of of IN cord-285335-agm4zbcx 26 4 FIP fip NN cord-285335-agm4zbcx 26 5 in in IN cord-285335-agm4zbcx 26 6 feline feline JJ cord-285335-agm4zbcx 26 7 populations population NNS cord-285335-agm4zbcx 26 8 is be VBZ cord-285335-agm4zbcx 26 9 rarely rarely RB cord-285335-agm4zbcx 26 10 higher high JJR cord-285335-agm4zbcx 26 11 than than IN cord-285335-agm4zbcx 26 12 5 5 CD cord-285335-agm4zbcx 26 13 % % NN cord-285335-agm4zbcx 26 14 ( ( -LRB- cord-285335-agm4zbcx 26 15 Hoskins Hoskins NNP cord-285335-agm4zbcx 26 16 , , , cord-285335-agm4zbcx 26 17 1993 1993 CD cord-285335-agm4zbcx 26 18 ) ) -RRB- cord-285335-agm4zbcx 26 19 . . . cord-285335-agm4zbcx 27 1 We -PRON- PRP cord-285335-agm4zbcx 27 2 investigated investigate VBD cord-285335-agm4zbcx 27 3 a a DT cord-285335-agm4zbcx 27 4 colony colony NN cord-285335-agm4zbcx 27 5 of of IN cord-285335-agm4zbcx 27 6 15 15 CD cord-285335-agm4zbcx 27 7 adult adult NN cord-285335-agm4zbcx 27 8 Persian persian JJ cord-285335-agm4zbcx 27 9 cats cat NNS cord-285335-agm4zbcx 27 10 that that WDT cord-285335-agm4zbcx 27 11 experienced experience VBD cord-285335-agm4zbcx 27 12 12 12 CD cord-285335-agm4zbcx 27 13 cases case NNS cord-285335-agm4zbcx 27 14 of of IN cord-285335-agm4zbcx 27 15 FIP FIP NNP cord-285335-agm4zbcx 27 16 in in IN cord-285335-agm4zbcx 27 17 their -PRON- PRP$ cord-285335-agm4zbcx 27 18 kittens kitten NNS cord-285335-agm4zbcx 27 19 over over IN cord-285335-agm4zbcx 27 20 2 2 CD cord-285335-agm4zbcx 27 21 years year NNS cord-285335-agm4zbcx 27 22 . . . cord-285335-agm4zbcx 28 1 We -PRON- PRP cord-285335-agm4zbcx 28 2 detected detect VBD cord-285335-agm4zbcx 28 3 FCoV FCoV NNP cord-285335-agm4zbcx 28 4 genetic genetic JJ cord-285335-agm4zbcx 28 5 material material NN cord-285335-agm4zbcx 28 6 in in IN cord-285335-agm4zbcx 28 7 the the DT cord-285335-agm4zbcx 28 8 feces fece NNS cord-285335-agm4zbcx 28 9 of of IN cord-285335-agm4zbcx 28 10 the the DT cord-285335-agm4zbcx 28 11 adult adult NN cord-285335-agm4zbcx 28 12 cats cat NNS cord-285335-agm4zbcx 28 13 as as RB cord-285335-agm4zbcx 28 14 well well RB cord-285335-agm4zbcx 28 15 as as IN cord-285335-agm4zbcx 28 16 tissue tissue NN cord-285335-agm4zbcx 28 17 and and CC cord-285335-agm4zbcx 28 18 fluid fluid JJ cord-285335-agm4zbcx 28 19 sample sample NN cord-285335-agm4zbcx 28 20 from from IN cord-285335-agm4zbcx 28 21 the the DT cord-285335-agm4zbcx 28 22 FIP FIP NNP cord-285335-agm4zbcx 28 23 victims victim NNS cord-285335-agm4zbcx 28 24 . . . cord-285335-agm4zbcx 29 1 The the DT cord-285335-agm4zbcx 29 2 7a/7b 7a/7b CD cord-285335-agm4zbcx 29 3 ORF ORF NNP cord-285335-agm4zbcx 29 4 from from IN cord-285335-agm4zbcx 29 5 the the DT cord-285335-agm4zbcx 29 6 FCoV FCoV NNP cord-285335-agm4zbcx 29 7 in in IN cord-285335-agm4zbcx 29 8 this this DT cord-285335-agm4zbcx 29 9 population population NN cord-285335-agm4zbcx 29 10 was be VBD cord-285335-agm4zbcx 29 11 characterized characterize VBN cord-285335-agm4zbcx 29 12 to to TO cord-285335-agm4zbcx 29 13 determine determine VB cord-285335-agm4zbcx 29 14 if if IN cord-285335-agm4zbcx 29 15 mutations mutation NNS cord-285335-agm4zbcx 29 16 in in IN cord-285335-agm4zbcx 29 17 this this DT cord-285335-agm4zbcx 29 18 region region NN cord-285335-agm4zbcx 29 19 were be VBD cord-285335-agm4zbcx 29 20 occurring occur VBG cord-285335-agm4zbcx 29 21 . . . cord-285335-agm4zbcx 30 1 A a DT cord-285335-agm4zbcx 30 2 Persian persian JJ cord-285335-agm4zbcx 30 3 cattery cattery NN cord-285335-agm4zbcx 30 4 consisting consist VBG cord-285335-agm4zbcx 30 5 of of IN cord-285335-agm4zbcx 30 6 15 15 CD cord-285335-agm4zbcx 30 7 adult adult NN cord-285335-agm4zbcx 30 8 cats cat NNS cord-285335-agm4zbcx 30 9 was be VBD cord-285335-agm4zbcx 30 10 selected select VBN cord-285335-agm4zbcx 30 11 for for IN cord-285335-agm4zbcx 30 12 study study NN cord-285335-agm4zbcx 30 13 . . . cord-285335-agm4zbcx 31 1 All all DT cord-285335-agm4zbcx 31 2 animals animal NNS cord-285335-agm4zbcx 31 3 in in IN cord-285335-agm4zbcx 31 4 the the DT cord-285335-agm4zbcx 31 5 population population NN cord-285335-agm4zbcx 31 6 were be VBD cord-285335-agm4zbcx 31 7 negative negative JJ cord-285335-agm4zbcx 31 8 for for IN cord-285335-agm4zbcx 31 9 feline feline JJ cord-285335-agm4zbcx 31 10 leukemia leukemia NN cord-285335-agm4zbcx 31 11 virus virus NN cord-285335-agm4zbcx 31 12 and and CC cord-285335-agm4zbcx 31 13 feline feline JJ cord-285335-agm4zbcx 31 14 lentivirus lentivirus NN cord-285335-agm4zbcx 31 15 . . . cord-285335-agm4zbcx 32 1 They -PRON- PRP cord-285335-agm4zbcx 32 2 were be VBD cord-285335-agm4zbcx 32 3 routinely routinely RB cord-285335-agm4zbcx 32 4 vaccinated vaccinate VBN cord-285335-agm4zbcx 32 5 for for IN cord-285335-agm4zbcx 32 6 feline feline JJ cord-285335-agm4zbcx 32 7 herpesvirus herpesvirus NN cord-285335-agm4zbcx 32 8 , , , cord-285335-agm4zbcx 32 9 calicivirus calicivirus NNP cord-285335-agm4zbcx 32 10 , , , cord-285335-agm4zbcx 32 11 panleukopenia panleukopenia NNP cord-285335-agm4zbcx 32 12 virus virus NN cord-285335-agm4zbcx 32 13 , , , cord-285335-agm4zbcx 32 14 and and CC cord-285335-agm4zbcx 32 15 rabies rabie NNS cord-285335-agm4zbcx 32 16 . . . cord-285335-agm4zbcx 33 1 Twelve twelve CD cord-285335-agm4zbcx 33 2 cases case NNS cord-285335-agm4zbcx 33 3 of of IN cord-285335-agm4zbcx 33 4 FIP FIP NNP cord-285335-agm4zbcx 33 5 occurred occur VBD cord-285335-agm4zbcx 33 6 in in IN cord-285335-agm4zbcx 33 7 six six CD cord-285335-agm4zbcx 33 8 litters litter NNS cord-285335-agm4zbcx 33 9 over over IN cord-285335-agm4zbcx 33 10 2 2 CD cord-285335-agm4zbcx 33 11 years year NNS cord-285335-agm4zbcx 33 12 ( ( -LRB- cord-285335-agm4zbcx 33 13 1997 1997 CD cord-285335-agm4zbcx 33 14 ) ) -RRB- cord-285335-agm4zbcx 34 1 ( ( -LRB- cord-285335-agm4zbcx 34 2 1998 1998 CD cord-285335-agm4zbcx 34 3 ) ) -RRB- cord-285335-agm4zbcx 34 4 ( ( -LRB- cord-285335-agm4zbcx 34 5 1999 1999 CD cord-285335-agm4zbcx 34 6 ) ) -RRB- cord-285335-agm4zbcx 34 7 . . . cord-285335-agm4zbcx 35 1 Diagnosis diagnosis NN cord-285335-agm4zbcx 35 2 was be VBD cord-285335-agm4zbcx 35 3 based base VBN cord-285335-agm4zbcx 35 4 on on IN cord-285335-agm4zbcx 35 5 clinical clinical JJ cord-285335-agm4zbcx 35 6 signs sign NNS cord-285335-agm4zbcx 35 7 , , , cord-285335-agm4zbcx 35 8 CBC CBC NNP cord-285335-agm4zbcx 35 9 and and CC cord-285335-agm4zbcx 35 10 blood blood NN cord-285335-agm4zbcx 35 11 chemistry chemistry NN cord-285335-agm4zbcx 35 12 , , , cord-285335-agm4zbcx 35 13 coronavirus coronavirus NN cord-285335-agm4zbcx 35 14 serology serology NN cord-285335-agm4zbcx 35 15 , , , cord-285335-agm4zbcx 35 16 histopathology histopathology NN cord-285335-agm4zbcx 35 17 , , , cord-285335-agm4zbcx 35 18 and and CC cord-285335-agm4zbcx 35 19 PCR PCR NNP cord-285335-agm4zbcx 35 20 on on IN cord-285335-agm4zbcx 35 21 plasma plasma NN cord-285335-agm4zbcx 35 22 or or CC cord-285335-agm4zbcx 35 23 effusion effusion NN cord-285335-agm4zbcx 35 24 . . . cord-285335-agm4zbcx 36 1 This this DT cord-285335-agm4zbcx 36 2 latter latter JJ cord-285335-agm4zbcx 36 3 parameter parameter NN cord-285335-agm4zbcx 36 4 was be VBD cord-285335-agm4zbcx 36 5 found find VBN cord-285335-agm4zbcx 36 6 to to TO cord-285335-agm4zbcx 36 7 correlate correlate VB cord-285335-agm4zbcx 36 8 with with IN cord-285335-agm4zbcx 36 9 histopathology histopathology NN cord-285335-agm4zbcx 36 10 for for IN cord-285335-agm4zbcx 36 11 diagnosis diagnosis NN cord-285335-agm4zbcx 36 12 of of IN cord-285335-agm4zbcx 36 13 FIP FIP NNP cord-285335-agm4zbcx 36 14 ( ( -LRB- cord-285335-agm4zbcx 36 15 Kennedy Kennedy NNP cord-285335-agm4zbcx 36 16 et et NNP cord-285335-agm4zbcx 36 17 al al NNP cord-285335-agm4zbcx 36 18 . . NNP cord-285335-agm4zbcx 36 19 , , , cord-285335-agm4zbcx 36 20 1998 1998 CD cord-285335-agm4zbcx 36 21 ) ) -RRB- cord-285335-agm4zbcx 36 22 . . . cord-285335-agm4zbcx 37 1 Fecal fecal JJ cord-285335-agm4zbcx 37 2 samples sample NNS cord-285335-agm4zbcx 37 3 , , , cord-285335-agm4zbcx 37 4 whole whole JJ cord-285335-agm4zbcx 37 5 blood blood NN cord-285335-agm4zbcx 37 6 , , , cord-285335-agm4zbcx 37 7 tissue tissue NN cord-285335-agm4zbcx 37 8 and and CC cord-285335-agm4zbcx 37 9 ascites ascite NNS cord-285335-agm4zbcx 37 10 from from IN cord-285335-agm4zbcx 37 11 two two CD cord-285335-agm4zbcx 37 12 clinical clinical JJ cord-285335-agm4zbcx 37 13 cases case NNS cord-285335-agm4zbcx 37 14 were be VBD cord-285335-agm4zbcx 37 15 collected collect VBN cord-285335-agm4zbcx 37 16 at at IN cord-285335-agm4zbcx 37 17 the the DT cord-285335-agm4zbcx 37 18 time time NN cord-285335-agm4zbcx 37 19 of of IN cord-285335-agm4zbcx 37 20 illness illness NN cord-285335-agm4zbcx 37 21 . . . cord-285335-agm4zbcx 38 1 In in IN cord-285335-agm4zbcx 38 2 addition addition NN cord-285335-agm4zbcx 38 3 , , , cord-285335-agm4zbcx 38 4 fecal fecal JJ cord-285335-agm4zbcx 38 5 and and CC cord-285335-agm4zbcx 38 6 whole whole JJ cord-285335-agm4zbcx 38 7 blood blood NN cord-285335-agm4zbcx 38 8 samples sample NNS cord-285335-agm4zbcx 38 9 were be VBD cord-285335-agm4zbcx 38 10 collected collect VBN cord-285335-agm4zbcx 38 11 from from IN cord-285335-agm4zbcx 38 12 seven seven CD cord-285335-agm4zbcx 38 13 adult adult NN cord-285335-agm4zbcx 38 14 cats cat NNS cord-285335-agm4zbcx 38 15 and and CC cord-285335-agm4zbcx 38 16 unaffected unaffected JJ cord-285335-agm4zbcx 38 17 kittens kitten NNS cord-285335-agm4zbcx 38 18 in in IN cord-285335-agm4zbcx 38 19 the the DT cord-285335-agm4zbcx 38 20 household household NN cord-285335-agm4zbcx 38 21 at at IN cord-285335-agm4zbcx 38 22 the the DT cord-285335-agm4zbcx 38 23 same same JJ cord-285335-agm4zbcx 38 24 time time NN cord-285335-agm4zbcx 38 25 point point NN cord-285335-agm4zbcx 38 26 . . . cord-285335-agm4zbcx 39 1 Total Total NNP cord-285335-agm4zbcx 39 2 RNA RNA NNP cord-285335-agm4zbcx 39 3 was be VBD cord-285335-agm4zbcx 39 4 extracted extract VBN cord-285335-agm4zbcx 39 5 from from IN cord-285335-agm4zbcx 39 6 the the DT cord-285335-agm4zbcx 39 7 specimens specimen NNS cord-285335-agm4zbcx 39 8 using use VBG cord-285335-agm4zbcx 39 9 Trizol Trizol NNP cord-285335-agm4zbcx 39 10 LS LS NNP cord-285335-agm4zbcx 39 11 according accord VBG cord-285335-agm4zbcx 39 12 to to IN cord-285335-agm4zbcx 39 13 the the DT cord-285335-agm4zbcx 39 14 manufacturer manufacturer NN cord-285335-agm4zbcx 39 15 's 's POS cord-285335-agm4zbcx 39 16 directions direction NNS cord-285335-agm4zbcx 39 17 for for IN cord-285335-agm4zbcx 39 18 reverse reverse JJ cord-285335-agm4zbcx 39 19 transcription transcription NN cord-285335-agm4zbcx 39 20 and and CC cord-285335-agm4zbcx 39 21 nested nested JJ cord-285335-agm4zbcx 39 22 polymerase polymerase NN cord-285335-agm4zbcx 39 23 chain chain NN cord-285335-agm4zbcx 39 24 reaction reaction NN cord-285335-agm4zbcx 39 25 ( ( -LRB- cord-285335-agm4zbcx 39 26 Gibco Gibco NNP cord-285335-agm4zbcx 39 27 BRL BRL NNP cord-285335-agm4zbcx 39 28 , , , cord-285335-agm4zbcx 39 29 Baltimore Baltimore NNP cord-285335-agm4zbcx 39 30 , , , cord-285335-agm4zbcx 39 31 MD MD NNP cord-285335-agm4zbcx 39 32 ) ) -RRB- cord-285335-agm4zbcx 39 33 . . . cord-285335-agm4zbcx 40 1 Primers primer NNS cord-285335-agm4zbcx 40 2 encompassed encompass VBD cord-285335-agm4zbcx 40 3 the the DT cord-285335-agm4zbcx 40 4 7a/7b 7a/7b CD cord-285335-agm4zbcx 40 5 ORFs ORFs NNP cord-285335-agm4zbcx 40 6 , , , cord-285335-agm4zbcx 40 7 the the DT cord-285335-agm4zbcx 40 8 3 3 CD cord-285335-agm4zbcx 40 9 0 0 CD cord-285335-agm4zbcx 40 10 -most -most NN cord-285335-agm4zbcx 40 11 ORFs orfs NN cord-285335-agm4zbcx 40 12 of of IN cord-285335-agm4zbcx 40 13 the the DT cord-285335-agm4zbcx 40 14 genome genome NN cord-285335-agm4zbcx 40 15 ( ( -LRB- cord-285335-agm4zbcx 40 16 Kennedy Kennedy NNP cord-285335-agm4zbcx 40 17 et et NNP cord-285335-agm4zbcx 40 18 al al NNP cord-285335-agm4zbcx 40 19 . . NNP cord-285335-agm4zbcx 40 20 , , , cord-285335-agm4zbcx 40 21 1998 1998 CD cord-285335-agm4zbcx 40 22 ) ) -RRB- cord-285335-agm4zbcx 40 23 . . . cord-285335-agm4zbcx 41 1 Reverse reverse JJ cord-285335-agm4zbcx 41 2 transcription transcription NN cord-285335-agm4zbcx 41 3 was be VBD cord-285335-agm4zbcx 41 4 done do VBN cord-285335-agm4zbcx 41 5 with with IN cord-285335-agm4zbcx 41 6 Moloney Moloney NNP cord-285335-agm4zbcx 41 7 murine murine JJ cord-285335-agm4zbcx 41 8 leukemia leukemia NN cord-285335-agm4zbcx 41 9 virus virus NN cord-285335-agm4zbcx 41 10 reverse reverse NN cord-285335-agm4zbcx 41 11 transcriptase transcriptase NN cord-285335-agm4zbcx 41 12 according accord VBG cord-285335-agm4zbcx 41 13 to to IN cord-285335-agm4zbcx 41 14 the the DT cord-285335-agm4zbcx 41 15 manufacturer manufacturer NN cord-285335-agm4zbcx 41 16 's 's POS cord-285335-agm4zbcx 41 17 recommendations recommendation NNS cord-285335-agm4zbcx 41 18 with with IN cord-285335-agm4zbcx 41 19 the the DT cord-285335-agm4zbcx 41 20 downstream downstream JJ cord-285335-agm4zbcx 41 21 external external JJ cord-285335-agm4zbcx 41 22 primer primer NN cord-285335-agm4zbcx 41 23 ( ( -LRB- cord-285335-agm4zbcx 41 24 Gibco Gibco NNP cord-285335-agm4zbcx 41 25 BRL BRL NNP cord-285335-agm4zbcx 41 26 , , , cord-285335-agm4zbcx 41 27 Baltimore Baltimore NNP cord-285335-agm4zbcx 41 28 , , , cord-285335-agm4zbcx 41 29 MD MD NNP cord-285335-agm4zbcx 41 30 ) ) -RRB- cord-285335-agm4zbcx 41 31 . . . cord-285335-agm4zbcx 42 1 Nested nested JJ cord-285335-agm4zbcx 42 2 polymerase polymerase NN cord-285335-agm4zbcx 42 3 chain chain NN cord-285335-agm4zbcx 42 4 reaction reaction NN cord-285335-agm4zbcx 42 5 was be VBD cord-285335-agm4zbcx 42 6 done do VBN cord-285335-agm4zbcx 42 7 using use VBG cord-285335-agm4zbcx 42 8 ExTaq ExTaq NNP cord-285335-agm4zbcx 42 9 polymerase polymerase NN cord-285335-agm4zbcx 42 10 ( ( -LRB- cord-285335-agm4zbcx 42 11 Intergen Intergen NNP cord-285335-agm4zbcx 42 12 , , , cord-285335-agm4zbcx 42 13 Purchase Purchase NNP cord-285335-agm4zbcx 42 14 , , , cord-285335-agm4zbcx 42 15 NY NY NNP cord-285335-agm4zbcx 42 16 ) ) -RRB- cord-285335-agm4zbcx 42 17 as as IN cord-285335-agm4zbcx 42 18 described describe VBN cord-285335-agm4zbcx 42 19 previously previously RB cord-285335-agm4zbcx 42 20 ( ( -LRB- cord-285335-agm4zbcx 42 21 Kennedy Kennedy NNP cord-285335-agm4zbcx 42 22 et et NNP cord-285335-agm4zbcx 42 23 al al NNP cord-285335-agm4zbcx 42 24 . . NNP cord-285335-agm4zbcx 42 25 , , , cord-285335-agm4zbcx 42 26 1998 1998 CD cord-285335-agm4zbcx 42 27 ) ) -RRB- cord-285335-agm4zbcx 42 28 . . . cord-285335-agm4zbcx 43 1 Products product NNS cord-285335-agm4zbcx 43 2 were be VBD cord-285335-agm4zbcx 43 3 analyzed analyze VBN cord-285335-agm4zbcx 43 4 on on IN cord-285335-agm4zbcx 43 5 a a DT cord-285335-agm4zbcx 43 6 1 1 CD cord-285335-agm4zbcx 43 7 % % NN cord-285335-agm4zbcx 43 8 agarose agarose NN cord-285335-agm4zbcx 43 9 gel gel NN cord-285335-agm4zbcx 43 10 . . . cord-285335-agm4zbcx 44 1 Amplification amplification NN cord-285335-agm4zbcx 44 2 products product NNS cord-285335-agm4zbcx 44 3 were be VBD cord-285335-agm4zbcx 44 4 cloned clone VBN cord-285335-agm4zbcx 44 5 into into IN cord-285335-agm4zbcx 44 6 PCR PCR NNP cord-285335-agm4zbcx 44 7 2.1 2.1 CD cord-285335-agm4zbcx 44 8 using use VBG cord-285335-agm4zbcx 44 9 the the DT cord-285335-agm4zbcx 44 10 TA TA NNP cord-285335-agm4zbcx 44 11 cloning clone VBG cord-285335-agm4zbcx 44 12 system system NN cord-285335-agm4zbcx 44 13 ( ( -LRB- cord-285335-agm4zbcx 44 14 Invitrogen Invitrogen NNP cord-285335-agm4zbcx 44 15 , , , cord-285335-agm4zbcx 44 16 Carlsbad Carlsbad NNP cord-285335-agm4zbcx 44 17 , , , cord-285335-agm4zbcx 44 18 CA CA NNP cord-285335-agm4zbcx 44 19 ) ) -RRB- cord-285335-agm4zbcx 44 20 . . . cord-285335-agm4zbcx 45 1 Cloned clone VBN cord-285335-agm4zbcx 45 2 cDNA cdna NN cord-285335-agm4zbcx 45 3 was be VBD cord-285335-agm4zbcx 45 4 sequenced sequence VBN cord-285335-agm4zbcx 45 5 by by IN cord-285335-agm4zbcx 45 6 Molecular Molecular NNP cord-285335-agm4zbcx 45 7 Biology Biology NNP cord-285335-agm4zbcx 45 8 Resources Resources NNPS cord-285335-agm4zbcx 45 9 Service Service NNP cord-285335-agm4zbcx 45 10 ( ( -LRB- cord-285335-agm4zbcx 45 11 University University NNP cord-285335-agm4zbcx 45 12 of of IN cord-285335-agm4zbcx 45 13 Tennessee Tennessee NNP cord-285335-agm4zbcx 45 14 , , , cord-285335-agm4zbcx 45 15 Knoxville Knoxville NNP cord-285335-agm4zbcx 45 16 , , , cord-285335-agm4zbcx 45 17 TN TN NNP cord-285335-agm4zbcx 45 18 ) ) -RRB- cord-285335-agm4zbcx 45 19 and and CC cord-285335-agm4zbcx 45 20 analyzed analyze VBD cord-285335-agm4zbcx 45 21 using use VBG cord-285335-agm4zbcx 45 22 GCG GCG NNP cord-285335-agm4zbcx 45 23 software software NN cord-285335-agm4zbcx 45 24 ( ( -LRB- cord-285335-agm4zbcx 45 25 University University NNP cord-285335-agm4zbcx 45 26 of of IN cord-285335-agm4zbcx 45 27 Wisconsin Wisconsin NNP cord-285335-agm4zbcx 45 28 , , , cord-285335-agm4zbcx 45 29 Madison Madison NNP cord-285335-agm4zbcx 45 30 , , , cord-285335-agm4zbcx 45 31 WI WI NNP cord-285335-agm4zbcx 45 32 ) ) -RRB- cord-285335-agm4zbcx 45 33 . . . cord-285335-agm4zbcx 46 1 A a DT cord-285335-agm4zbcx 46 2 minimum minimum NN cord-285335-agm4zbcx 46 3 of of IN cord-285335-agm4zbcx 46 4 two two CD cord-285335-agm4zbcx 46 5 clones clone NNS cord-285335-agm4zbcx 46 6 from from IN cord-285335-agm4zbcx 46 7 two two CD cord-285335-agm4zbcx 46 8 separate separate JJ cord-285335-agm4zbcx 46 9 PCR PCR NNP cord-285335-agm4zbcx 46 10 reactions reaction NNS cord-285335-agm4zbcx 46 11 was be VBD cord-285335-agm4zbcx 46 12 used use VBN cord-285335-agm4zbcx 46 13 for for IN cord-285335-agm4zbcx 46 14 sequencing sequencing NN cord-285335-agm4zbcx 46 15 and and CC cord-285335-agm4zbcx 46 16 analysis analysis NN cord-285335-agm4zbcx 46 17 . . . cord-285335-agm4zbcx 47 1 We -PRON- PRP cord-285335-agm4zbcx 47 2 detected detect VBD cord-285335-agm4zbcx 47 3 FCoV FCoV NNP cord-285335-agm4zbcx 47 4 in in IN cord-285335-agm4zbcx 47 5 a a DT cord-285335-agm4zbcx 47 6 purebred purebred JJ cord-285335-agm4zbcx 47 7 population population NN cord-285335-agm4zbcx 47 8 of of IN cord-285335-agm4zbcx 47 9 cats cat NNS cord-285335-agm4zbcx 47 10 that that WDT cord-285335-agm4zbcx 47 11 had have VBD cord-285335-agm4zbcx 47 12 experienced experience VBN cord-285335-agm4zbcx 47 13 a a DT cord-285335-agm4zbcx 47 14 high high JJ cord-285335-agm4zbcx 47 15 rate rate NN cord-285335-agm4zbcx 47 16 of of IN cord-285335-agm4zbcx 47 17 FIP fip NN cord-285335-agm4zbcx 47 18 over over IN cord-285335-agm4zbcx 47 19 a a DT cord-285335-agm4zbcx 47 20 2-year 2-year CD cord-285335-agm4zbcx 47 21 period period NN cord-285335-agm4zbcx 47 22 , , , cord-285335-agm4zbcx 47 23 with with IN cord-285335-agm4zbcx 47 24 12 12 CD cord-285335-agm4zbcx 47 25 cases case NNS cord-285335-agm4zbcx 47 26 of of IN cord-285335-agm4zbcx 47 27 FIP FIP NNP cord-285335-agm4zbcx 47 28 in in IN cord-285335-agm4zbcx 47 29 six six CD cord-285335-agm4zbcx 47 30 litters litter NNS cord-285335-agm4zbcx 47 31 . . . cord-285335-agm4zbcx 48 1 The the DT cord-285335-agm4zbcx 48 2 FCoV FCoV NNP cord-285335-agm4zbcx 48 3 infecting infect VBG cord-285335-agm4zbcx 48 4 the the DT cord-285335-agm4zbcx 48 5 population population NN cord-285335-agm4zbcx 48 6 was be VBD cord-285335-agm4zbcx 48 7 analyzed analyze VBN cord-285335-agm4zbcx 48 8 , , , cord-285335-agm4zbcx 48 9 focusing focus VBG cord-285335-agm4zbcx 48 10 on on IN cord-285335-agm4zbcx 48 11 the the DT cord-285335-agm4zbcx 48 12 7a/7b 7a/7b CD cord-285335-agm4zbcx 48 13 ORF ORF NNP cord-285335-agm4zbcx 48 14 . . . cord-285335-agm4zbcx 49 1 This this DT cord-285335-agm4zbcx 49 2 genomic genomic JJ cord-285335-agm4zbcx 49 3 region region NN cord-285335-agm4zbcx 49 4 was be VBD cord-285335-agm4zbcx 49 5 chosen choose VBN cord-285335-agm4zbcx 49 6 for for IN cord-285335-agm4zbcx 49 7 analysis analysis NN cord-285335-agm4zbcx 49 8 because because IN cord-285335-agm4zbcx 49 9 of of IN cord-285335-agm4zbcx 49 10 its -PRON- PRP$ cord-285335-agm4zbcx 49 11 speculated speculate VBN cord-285335-agm4zbcx 49 12 role role NN cord-285335-agm4zbcx 49 13 in in IN cord-285335-agm4zbcx 49 14 virulence virulence NN cord-285335-agm4zbcx 49 15 ( ( -LRB- cord-285335-agm4zbcx 49 16 Vennema Vennema NNP cord-285335-agm4zbcx 49 17 et et FW cord-285335-agm4zbcx 49 18 al al NNP cord-285335-agm4zbcx 49 19 . . NNP cord-285335-agm4zbcx 49 20 , , , cord-285335-agm4zbcx 49 21 1992 1992 CD cord-285335-agm4zbcx 49 22 ; ; : cord-285335-agm4zbcx 49 23 Herrewegh Herrewegh NNP cord-285335-agm4zbcx 49 24 et et NNP cord-285335-agm4zbcx 49 25 al al NNP cord-285335-agm4zbcx 49 26 . . NNP cord-285335-agm4zbcx 49 27 , , , cord-285335-agm4zbcx 49 28 1995 1995 CD cord-285335-agm4zbcx 49 29 ; ; : cord-285335-agm4zbcx 49 30 Vennema Vennema NNP cord-285335-agm4zbcx 49 31 et et FW cord-285335-agm4zbcx 49 32 al al NNP cord-285335-agm4zbcx 49 33 . . NNP cord-285335-agm4zbcx 49 34 , , , cord-285335-agm4zbcx 49 35 1998 1998 CD cord-285335-agm4zbcx 49 36 ) ) -RRB- cord-285335-agm4zbcx 49 37 . . . cord-285335-agm4zbcx 50 1 Amplification amplification NN cord-285335-agm4zbcx 50 2 of of IN cord-285335-agm4zbcx 50 3 FCoV FCoV NNP cord-285335-agm4zbcx 50 4 RNA RNA NNP cord-285335-agm4zbcx 50 5 was be VBD cord-285335-agm4zbcx 50 6 successful successful JJ cord-285335-agm4zbcx 50 7 in in IN cord-285335-agm4zbcx 50 8 samples sample NNS cord-285335-agm4zbcx 50 9 from from IN cord-285335-agm4zbcx 50 10 nine nine CD cord-285335-agm4zbcx 50 11 cats cat NNS cord-285335-agm4zbcx 50 12 . . . cord-285335-agm4zbcx 51 1 Seven seven CD cord-285335-agm4zbcx 51 2 of of IN cord-285335-agm4zbcx 51 3 these these DT cord-285335-agm4zbcx 51 4 were be VBD cord-285335-agm4zbcx 51 5 resident resident JJ cord-285335-agm4zbcx 51 6 adults adult NNS cord-285335-agm4zbcx 51 7 and and CC cord-285335-agm4zbcx 51 8 included include VBD cord-285335-agm4zbcx 51 9 the the DT cord-285335-agm4zbcx 51 10 sire sire NN cord-285335-agm4zbcx 51 11 and and CC cord-285335-agm4zbcx 51 12 queens queen NNS cord-285335-agm4zbcx 51 13 of of IN cord-285335-agm4zbcx 51 14 affected affect VBN cord-285335-agm4zbcx 51 15 offspring offspring NN cord-285335-agm4zbcx 51 16 . . . cord-285335-agm4zbcx 52 1 Two two CD cord-285335-agm4zbcx 52 2 were be VBD cord-285335-agm4zbcx 52 3 from from IN cord-285335-agm4zbcx 52 4 kittens kitten NNS cord-285335-agm4zbcx 52 5 that that WDT cord-285335-agm4zbcx 52 6 died die VBD cord-285335-agm4zbcx 52 7 from from IN cord-285335-agm4zbcx 52 8 FIP FIP NNP cord-285335-agm4zbcx 52 9 . . . cord-285335-agm4zbcx 53 1 Two two CD cord-285335-agm4zbcx 53 2 distinct distinct JJ cord-285335-agm4zbcx 53 3 virus virus NN cord-285335-agm4zbcx 53 4 variants variant NNS cord-285335-agm4zbcx 53 5 were be VBD cord-285335-agm4zbcx 53 6 found find VBN cord-285335-agm4zbcx 53 7 , , , cord-285335-agm4zbcx 53 8 one one CD cord-285335-agm4zbcx 53 9 with with IN cord-285335-agm4zbcx 53 10 an an DT cord-285335-agm4zbcx 53 11 intact intact JJ cord-285335-agm4zbcx 53 12 7a 7a NN cord-285335-agm4zbcx 53 13 ORF ORF NNP cord-285335-agm4zbcx 53 14 and and CC cord-285335-agm4zbcx 53 15 one one CD cord-285335-agm4zbcx 53 16 with with IN cord-285335-agm4zbcx 53 17 two two CD cord-285335-agm4zbcx 53 18 deletions deletion NNS cord-285335-agm4zbcx 53 19 in in IN cord-285335-agm4zbcx 53 20 the the DT cord-285335-agm4zbcx 53 21 7a 7a NN cord-285335-agm4zbcx 53 22 ORF ORF NNP cord-285335-agm4zbcx 53 23 ( ( -LRB- cord-285335-agm4zbcx 53 24 Fig Fig NNP cord-285335-agm4zbcx 53 25 . . . cord-285335-agm4zbcx 53 26 1 1 CD cord-285335-agm4zbcx 53 27 ) ) -RRB- cord-285335-agm4zbcx 53 28 . . . cord-285335-agm4zbcx 54 1 The the DT cord-285335-agm4zbcx 54 2 deletions deletion NNS cord-285335-agm4zbcx 54 3 encompassed encompass VBD cord-285335-agm4zbcx 54 4 nucleotides nucleotide NNS cord-285335-agm4zbcx 54 5 20 20 CD cord-285335-agm4zbcx 54 6 - - SYM cord-285335-agm4zbcx 54 7 120 120 CD cord-285335-agm4zbcx 54 8 and and CC cord-285335-agm4zbcx 54 9 nucleotides nucleotide NNS cord-285335-agm4zbcx 54 10 164 164 CD cord-285335-agm4zbcx 54 11 - - SYM cord-285335-agm4zbcx 54 12 226 226 CD cord-285335-agm4zbcx 54 13 of of IN cord-285335-agm4zbcx 54 14 the the DT cord-285335-agm4zbcx 54 15 7a 7a NN cord-285335-agm4zbcx 54 16 gene gene NN cord-285335-agm4zbcx 54 17 . . . cord-285335-agm4zbcx 55 1 Four four CD cord-285335-agm4zbcx 55 2 additional additional JJ cord-285335-agm4zbcx 55 3 nucleotides nucleotide NNS cord-285335-agm4zbcx 55 4 ( ( -LRB- cord-285335-agm4zbcx 55 5 TCTT TCTT NNP cord-285335-agm4zbcx 55 6 ) ) -RRB- cord-285335-agm4zbcx 55 7 were be VBD cord-285335-agm4zbcx 55 8 present present JJ cord-285335-agm4zbcx 55 9 in in IN cord-285335-agm4zbcx 55 10 all all DT cord-285335-agm4zbcx 55 11 of of IN cord-285335-agm4zbcx 55 12 the the DT cord-285335-agm4zbcx 55 13 deletion deletion NN cord-285335-agm4zbcx 55 14 mutants mutant NNS cord-285335-agm4zbcx 55 15 at at IN cord-285335-agm4zbcx 55 16 the the DT cord-285335-agm4zbcx 55 17 position position NN cord-285335-agm4zbcx 55 18 corresponding correspond VBG cord-285335-agm4zbcx 55 19 to to IN cord-285335-agm4zbcx 55 20 nucleotide nucleotide JJ cord-285335-agm4zbcx 55 21 227 227 CD cord-285335-agm4zbcx 55 22 of of IN cord-285335-agm4zbcx 55 23 the the DT cord-285335-agm4zbcx 55 24 undeleted undeleted JJ cord-285335-agm4zbcx 55 25 virus virus NN cord-285335-agm4zbcx 55 26 . . . cord-285335-agm4zbcx 56 1 The the DT cord-285335-agm4zbcx 56 2 protein protein NN cord-285335-agm4zbcx 56 3 predicted predict VBD cord-285335-agm4zbcx 56 4 from from IN cord-285335-agm4zbcx 56 5 the the DT cord-285335-agm4zbcx 56 6 nucleotide nucleotide JJ cord-285335-agm4zbcx 56 7 sequence sequence NN cord-285335-agm4zbcx 56 8 contains contain VBZ cord-285335-agm4zbcx 56 9 different different JJ cord-285335-agm4zbcx 56 10 amino amino NN cord-285335-agm4zbcx 56 11 acids acid NNS cord-285335-agm4zbcx 56 12 in in IN cord-285335-agm4zbcx 56 13 the the DT cord-285335-agm4zbcx 56 14 3 3 CD cord-285335-agm4zbcx 56 15 0 0 CD cord-285335-agm4zbcx 56 16 one one CD cord-285335-agm4zbcx 56 17 - - HYPH cord-285335-agm4zbcx 56 18 half half NN cord-285335-agm4zbcx 56 19 of of IN cord-285335-agm4zbcx 56 20 the the DT cord-285335-agm4zbcx 56 21 predicted predict VBN cord-285335-agm4zbcx 56 22 protein protein NN cord-285335-agm4zbcx 56 23 due due IN cord-285335-agm4zbcx 56 24 to to IN cord-285335-agm4zbcx 56 25 the the DT cord-285335-agm4zbcx 56 26 altered altered JJ cord-285335-agm4zbcx 56 27 reading reading NN cord-285335-agm4zbcx 56 28 frame frame NN cord-285335-agm4zbcx 56 29 caused cause VBN cord-285335-agm4zbcx 56 30 by by IN cord-285335-agm4zbcx 56 31 the the DT cord-285335-agm4zbcx 56 32 second second JJ cord-285335-agm4zbcx 56 33 deletion deletion NN cord-285335-agm4zbcx 56 34 ( ( -LRB- cord-285335-agm4zbcx 56 35 Fig fig NN cord-285335-agm4zbcx 56 36 . . NNP cord-285335-agm4zbcx 56 37 2 2 CD cord-285335-agm4zbcx 56 38 ) ) -RRB- cord-285335-agm4zbcx 56 39 . . . cord-285335-agm4zbcx 57 1 It -PRON- PRP cord-285335-agm4zbcx 57 2 is be VBZ cord-285335-agm4zbcx 57 3 not not RB cord-285335-agm4zbcx 57 4 known know VBN cord-285335-agm4zbcx 57 5 if if IN cord-285335-agm4zbcx 57 6 the the DT cord-285335-agm4zbcx 57 7 7a 7a NN cord-285335-agm4zbcx 57 8 protein protein NN cord-285335-agm4zbcx 57 9 predicted predict VBD cord-285335-agm4zbcx 57 10 from from IN cord-285335-agm4zbcx 57 11 the the DT cord-285335-agm4zbcx 57 12 nucleotide nucleotide JJ cord-285335-agm4zbcx 57 13 sequence sequence NN cord-285335-agm4zbcx 57 14 is be VBZ cord-285335-agm4zbcx 57 15 expressed express VBN cord-285335-agm4zbcx 57 16 in in IN cord-285335-agm4zbcx 57 17 the the DT cord-285335-agm4zbcx 57 18 deletion deletion NN cord-285335-agm4zbcx 57 19 mutant mutant JJ cord-285335-agm4zbcx 57 20 virus virus NN cord-285335-agm4zbcx 57 21 . . . cord-285335-agm4zbcx 58 1 The the DT cord-285335-agm4zbcx 58 2 remainder remainder NN cord-285335-agm4zbcx 58 3 of of IN cord-285335-agm4zbcx 58 4 the the DT cord-285335-agm4zbcx 58 5 7a/7b 7a/7b CD cord-285335-agm4zbcx 58 6 ORF ORF NNP cord-285335-agm4zbcx 58 7 was be VBD cord-285335-agm4zbcx 58 8 highly highly RB cord-285335-agm4zbcx 58 9 conserved conserve VBN cord-285335-agm4zbcx 58 10 among among IN cord-285335-agm4zbcx 58 11 all all DT cord-285335-agm4zbcx 58 12 isolates isolate NNS cord-285335-agm4zbcx 58 13 , , , cord-285335-agm4zbcx 58 14 including include VBG cord-285335-agm4zbcx 58 15 the the DT cord-285335-agm4zbcx 58 16 region region NN cord-285335-agm4zbcx 58 17 encoding encode VBG cord-285335-agm4zbcx 58 18 the the DT cord-285335-agm4zbcx 58 19 7b 7b JJ cord-285335-agm4zbcx 58 20 ORF ORF NNP cord-285335-agm4zbcx 58 21 ( ( -LRB- cord-285335-agm4zbcx 58 22 Fig Fig NNP cord-285335-agm4zbcx 58 23 . . . cord-285335-agm4zbcx 58 24 3 3 CD cord-285335-agm4zbcx 58 25 ) ) -RRB- cord-285335-agm4zbcx 58 26 . . . cord-285335-agm4zbcx 59 1 Interestingly interestingly RB cord-285335-agm4zbcx 59 2 , , , cord-285335-agm4zbcx 59 3 amino amino NN cord-285335-agm4zbcx 59 4 acid acid NN cord-285335-agm4zbcx 59 5 residues residue NNS cord-285335-agm4zbcx 59 6 202 202 CD cord-285335-agm4zbcx 59 7 and and CC cord-285335-agm4zbcx 59 8 203 203 CD cord-285335-agm4zbcx 59 9 of of IN cord-285335-agm4zbcx 59 10 the the DT cord-285335-agm4zbcx 59 11 predicted predict VBN cord-285335-agm4zbcx 59 12 7b 7b NN cord-285335-agm4zbcx 59 13 protein protein NN cord-285335-agm4zbcx 59 14 were be VBD cord-285335-agm4zbcx 59 15 histidine histidine NN cord-285335-agm4zbcx 59 16 and and CC cord-285335-agm4zbcx 59 17 lysine lysine NN cord-285335-agm4zbcx 59 18 . . . cord-285335-agm4zbcx 60 1 This this DT cord-285335-agm4zbcx 60 2 is be VBZ cord-285335-agm4zbcx 60 3 contrary contrary JJ cord-285335-agm4zbcx 60 4 to to IN cord-285335-agm4zbcx 60 5 the the DT cord-285335-agm4zbcx 60 6 findings finding NNS cord-285335-agm4zbcx 60 7 of of IN cord-285335-agm4zbcx 60 8 Vennema Vennema NNP cord-285335-agm4zbcx 60 9 et et FW cord-285335-agm4zbcx 60 10 al al NNP cord-285335-agm4zbcx 60 11 . . . cord-285335-agm4zbcx 61 1 ( ( -LRB- cord-285335-agm4zbcx 61 2 1998 1998 CD cord-285335-agm4zbcx 61 3 ) ) -RRB- cord-285335-agm4zbcx 61 4 that that IN cord-285335-agm4zbcx 61 5 FIP FIP NNP cord-285335-agm4zbcx 61 6 viruses virus NNS cord-285335-agm4zbcx 61 7 contained contain VBD cord-285335-agm4zbcx 61 8 tyrosine tyrosine NN cord-285335-agm4zbcx 61 9 and and CC cord-285335-agm4zbcx 61 10 lysine lysine NN cord-285335-agm4zbcx 61 11 at at IN cord-285335-agm4zbcx 61 12 these these DT cord-285335-agm4zbcx 61 13 positions position NNS cord-285335-agm4zbcx 61 14 whereas whereas IN cord-285335-agm4zbcx 61 15 putative putative JJ cord-285335-agm4zbcx 61 16 avirulent avirulent NNP cord-285335-agm4zbcx 61 17 FCoV FCoV NNP cord-285335-agm4zbcx 61 18 contained contain VBD cord-285335-agm4zbcx 61 19 histidine histidine NN cord-285335-agm4zbcx 61 20 and and CC cord-285335-agm4zbcx 61 21 arginine arginine NN cord-285335-agm4zbcx 61 22 . . . cord-285335-agm4zbcx 62 1 Both both DT cord-285335-agm4zbcx 62 2 virus virus NN cord-285335-agm4zbcx 62 3 variants variant NNS cord-285335-agm4zbcx 62 4 were be VBD cord-285335-agm4zbcx 62 5 identified identify VBN cord-285335-agm4zbcx 62 6 in in IN cord-285335-agm4zbcx 62 7 one one CD cord-285335-agm4zbcx 62 8 cat cat NN cord-285335-agm4zbcx 62 9 , , , cord-285335-agm4zbcx 62 10 the the DT cord-285335-agm4zbcx 62 11 sire sire NN cord-285335-agm4zbcx 62 12 ' ' '' cord-285335-agm4zbcx 62 13 ' ' `` cord-285335-agm4zbcx 62 14 Dan Dan NNP cord-285335-agm4zbcx 62 15 ' ' '' cord-285335-agm4zbcx 62 16 ' ' '' cord-285335-agm4zbcx 62 17 , , , cord-285335-agm4zbcx 62 18 as as IN cord-285335-agm4zbcx 62 19 sequence sequence NN cord-285335-agm4zbcx 62 20 analysis analysis NN cord-285335-agm4zbcx 62 21 of of IN cord-285335-agm4zbcx 62 22 clones clone NNS cord-285335-agm4zbcx 62 23 from from IN cord-285335-agm4zbcx 62 24 a a DT cord-285335-agm4zbcx 62 25 single single JJ cord-285335-agm4zbcx 62 26 PCR pcr NN cord-285335-agm4zbcx 62 27 from from IN cord-285335-agm4zbcx 62 28 this this DT cord-285335-agm4zbcx 62 29 animal animal NN cord-285335-agm4zbcx 62 30 revealed reveal VBD cord-285335-agm4zbcx 62 31 the the DT cord-285335-agm4zbcx 62 32 presence presence NN cord-285335-agm4zbcx 62 33 of of IN cord-285335-agm4zbcx 62 34 the the DT cord-285335-agm4zbcx 62 35 7a 7a NN cord-285335-agm4zbcx 62 36 deletion deletion NN cord-285335-agm4zbcx 62 37 mutant mutant JJ cord-285335-agm4zbcx 62 38 as as RB cord-285335-agm4zbcx 62 39 well well RB cord-285335-agm4zbcx 62 40 as as IN cord-285335-agm4zbcx 62 41 the the DT cord-285335-agm4zbcx 62 42 intact intact JJ cord-285335-agm4zbcx 62 43 isolate isolate VBP cord-285335-agm4zbcx 62 44 ( ( -LRB- cord-285335-agm4zbcx 62 45 Dan Dan NNP cord-285335-agm4zbcx 62 46 1 1 CD cord-285335-agm4zbcx 62 47 and and CC cord-285335-agm4zbcx 62 48 2 2 CD cord-285335-agm4zbcx 62 49 in in IN cord-285335-agm4zbcx 62 50 Fig Fig NNP cord-285335-agm4zbcx 62 51 . . NNP cord-285335-agm4zbcx 62 52 2 2 CD cord-285335-agm4zbcx 62 53 ) ) -RRB- cord-285335-agm4zbcx 62 54 . . . cord-285335-agm4zbcx 63 1 This this DT cord-285335-agm4zbcx 63 2 cat cat NN cord-285335-agm4zbcx 63 3 was be VBD cord-285335-agm4zbcx 63 4 PCR pcr NN cord-285335-agm4zbcx 63 5 - - HYPH cord-285335-agm4zbcx 63 6 positive positive JJ cord-285335-agm4zbcx 63 7 for for IN cord-285335-agm4zbcx 63 8 virus virus NN cord-285335-agm4zbcx 63 9 in in IN cord-285335-agm4zbcx 63 10 multiple multiple JJ cord-285335-agm4zbcx 63 11 samples sample NNS cord-285335-agm4zbcx 63 12 and and CC cord-285335-agm4zbcx 63 13 may may MD cord-285335-agm4zbcx 63 14 be be VB cord-285335-agm4zbcx 63 15 persistently persistently RB cord-285335-agm4zbcx 63 16 infected infect VBN cord-285335-agm4zbcx 63 17 with with IN cord-285335-agm4zbcx 63 18 FCoV. fcov. NN cord-285335-agm4zbcx 64 1 He -PRON- PRP cord-285335-agm4zbcx 64 2 was be VBD cord-285335-agm4zbcx 64 3 also also RB cord-285335-agm4zbcx 64 4 the the DT cord-285335-agm4zbcx 64 5 sire sire NN cord-285335-agm4zbcx 64 6 of of IN cord-285335-agm4zbcx 64 7 all all PDT cord-285335-agm4zbcx 64 8 the the DT cord-285335-agm4zbcx 64 9 FIP FIP NNP cord-285335-agm4zbcx 64 10 victims victim NNS cord-285335-agm4zbcx 64 11 in in IN cord-285335-agm4zbcx 64 12 the the DT cord-285335-agm4zbcx 64 13 first first JJ cord-285335-agm4zbcx 64 14 18 18 CD cord-285335-agm4zbcx 64 15 months month NNS cord-285335-agm4zbcx 64 16 of of IN cord-285335-agm4zbcx 64 17 the the DT cord-285335-agm4zbcx 64 18 study study NN cord-285335-agm4zbcx 64 19 . . . cord-285335-agm4zbcx 65 1 Litters litter NNS cord-285335-agm4zbcx 65 2 resulting result VBG cord-285335-agm4zbcx 65 3 from from IN cord-285335-agm4zbcx 65 4 the the DT cord-285335-agm4zbcx 65 5 breeding breeding NN cord-285335-agm4zbcx 65 6 of of IN cord-285335-agm4zbcx 65 7 this this DT cord-285335-agm4zbcx 65 8 sire sire NN cord-285335-agm4zbcx 65 9 to to IN cord-285335-agm4zbcx 65 10 his -PRON- PRP$ cord-285335-agm4zbcx 65 11 daughters daughter NNS cord-285335-agm4zbcx 65 12 from from IN cord-285335-agm4zbcx 65 13 previous previous JJ cord-285335-agm4zbcx 65 14 litters litter NNS cord-285335-agm4zbcx 65 15 experienced experience VBD cord-285335-agm4zbcx 65 16 morbidity morbidity NN cord-285335-agm4zbcx 65 17 and and CC cord-285335-agm4zbcx 65 18 mortality mortality NN cord-285335-agm4zbcx 65 19 of of IN cord-285335-agm4zbcx 65 20 75 75 CD cord-285335-agm4zbcx 65 21 - - SYM cord-285335-agm4zbcx 65 22 100 100 CD cord-285335-agm4zbcx 65 23 % % NN cord-285335-agm4zbcx 65 24 within within IN cord-285335-agm4zbcx 65 25 the the DT cord-285335-agm4zbcx 65 26 litter litter NN cord-285335-agm4zbcx 65 27 ( ( -LRB- cord-285335-agm4zbcx 65 28 n n NN cord-285335-agm4zbcx 65 29 ¼ ¼ NNP cord-285335-agm4zbcx 65 30 4 4 CD cord-285335-agm4zbcx 65 31 ) ) -RRB- cord-285335-agm4zbcx 65 32 . . . cord-285335-agm4zbcx 66 1 During during IN cord-285335-agm4zbcx 66 2 the the DT cord-285335-agm4zbcx 66 3 last last JJ cord-285335-agm4zbcx 66 4 6 6 CD cord-285335-agm4zbcx 66 5 months month NNS cord-285335-agm4zbcx 66 6 of of IN cord-285335-agm4zbcx 66 7 the the DT cord-285335-agm4zbcx 66 8 FIP FIP NNP cord-285335-agm4zbcx 66 9 outbreak outbreak NN cord-285335-agm4zbcx 66 10 , , , cord-285335-agm4zbcx 66 11 a a DT cord-285335-agm4zbcx 66 12 new new JJ cord-285335-agm4zbcx 66 13 sire sire NN cord-285335-agm4zbcx 66 14 was be VBD cord-285335-agm4zbcx 66 15 used use VBN cord-285335-agm4zbcx 66 16 and and CC cord-285335-agm4zbcx 66 17 bred breed VBN cord-285335-agm4zbcx 66 18 to to IN cord-285335-agm4zbcx 66 19 the the DT cord-285335-agm4zbcx 66 20 original original JJ cord-285335-agm4zbcx 66 21 sire sire NN cord-285335-agm4zbcx 66 22 's 's POS cord-285335-agm4zbcx 66 23 daughters daughter NNS cord-285335-agm4zbcx 66 24 . . . cord-285335-agm4zbcx 67 1 Morbidity morbidity NN cord-285335-agm4zbcx 67 2 and and CC cord-285335-agm4zbcx 67 3 mortality mortality NN cord-285335-agm4zbcx 67 4 has have VBZ cord-285335-agm4zbcx 67 5 since since IN cord-285335-agm4zbcx 67 6 decreased decrease VBN cord-285335-agm4zbcx 67 7 to to IN cord-285335-agm4zbcx 67 8 0 0 CD cord-285335-agm4zbcx 67 9 - - SYM cord-285335-agm4zbcx 67 10 25 25 CD cord-285335-agm4zbcx 67 11 % % NN cord-285335-agm4zbcx 67 12 within within IN cord-285335-agm4zbcx 67 13 litters litter NNS cord-285335-agm4zbcx 67 14 ( ( -LRB- cord-285335-agm4zbcx 67 15 n n CC cord-285335-agm4zbcx 67 16 ¼ ¼ NNP cord-285335-agm4zbcx 67 17 4 4 CD cord-285335-agm4zbcx 67 18 ) ) -RRB- cord-285335-agm4zbcx 67 19 , , , cord-285335-agm4zbcx 67 20 with with IN cord-285335-agm4zbcx 67 21 the the DT cord-285335-agm4zbcx 67 22 last last JJ cord-285335-agm4zbcx 67 23 case case NN cord-285335-agm4zbcx 67 24 occurring occur VBG cord-285335-agm4zbcx 67 25 in in IN cord-285335-agm4zbcx 67 26 spring spring NN cord-285335-agm4zbcx 67 27 of of IN cord-285335-agm4zbcx 67 28 1999 1999 CD cord-285335-agm4zbcx 67 29 . . . cord-285335-agm4zbcx 68 1 Amplification amplification NN cord-285335-agm4zbcx 68 2 of of IN cord-285335-agm4zbcx 68 3 FCoV FCoV NNP cord-285335-agm4zbcx 68 4 7a/7b 7a/7b CD cord-285335-agm4zbcx 68 5 ORF ORF NNP cord-285335-agm4zbcx 68 6 from from IN cord-285335-agm4zbcx 68 7 the the DT cord-285335-agm4zbcx 68 8 most most RBS cord-285335-agm4zbcx 68 9 recent recent JJ cord-285335-agm4zbcx 68 10 cases case NNS cord-285335-agm4zbcx 68 11 of of IN cord-285335-agm4zbcx 68 12 FIP FIP NNP cord-285335-agm4zbcx 68 13 ( ( -LRB- cord-285335-agm4zbcx 68 14 n n NN cord-285335-agm4zbcx 68 15 ¼ ¼ NNP cord-285335-agm4zbcx 68 16 4 4 CD cord-285335-agm4zbcx 68 17 ) ) -RRB- cord-285335-agm4zbcx 68 18 have have VBP cord-285335-agm4zbcx 68 19 not not RB cord-285335-agm4zbcx 68 20 been be VBN cord-285335-agm4zbcx 68 21 successful successful JJ cord-285335-agm4zbcx 68 22 . . . cord-285335-agm4zbcx 69 1 Fig Fig NNP cord-285335-agm4zbcx 69 2 . . NNP cord-285335-agm4zbcx 69 3 4 4 CD cord-285335-agm4zbcx 69 4 shows show VBZ cord-285335-agm4zbcx 69 5 the the DT cord-285335-agm4zbcx 69 6 phylogenic phylogenic NN cord-285335-agm4zbcx 69 7 relationship relationship NN cord-285335-agm4zbcx 69 8 among among IN cord-285335-agm4zbcx 69 9 the the DT cord-285335-agm4zbcx 69 10 virus virus NN cord-285335-agm4zbcx 69 11 isolates isolate VBZ cord-285335-agm4zbcx 69 12 resulting result VBG cord-285335-agm4zbcx 69 13 from from IN cord-285335-agm4zbcx 69 14 nucleotide nucleotide JJ cord-285335-agm4zbcx 69 15 sequence sequence NN cord-285335-agm4zbcx 69 16 alignments alignment NNS cord-285335-agm4zbcx 69 17 . . . cord-285335-agm4zbcx 70 1 The the DT cord-285335-agm4zbcx 70 2 two two CD cord-285335-agm4zbcx 70 3 distinct distinct JJ cord-285335-agm4zbcx 70 4 variants variant NNS cord-285335-agm4zbcx 70 5 are be VBP cord-285335-agm4zbcx 70 6 clearly clearly RB cord-285335-agm4zbcx 70 7 delineated delineate VBN cord-285335-agm4zbcx 70 8 . . . cord-285335-agm4zbcx 71 1 The the DT cord-285335-agm4zbcx 71 2 deletion deletion NN cord-285335-agm4zbcx 71 3 mutants mutant NNS cord-285335-agm4zbcx 71 4 show show VBP cord-285335-agm4zbcx 71 5 a a DT cord-285335-agm4zbcx 71 6 very very RB cord-285335-agm4zbcx 71 7 close close JJ cord-285335-agm4zbcx 71 8 similarity similarity NN cord-285335-agm4zbcx 71 9 to to IN cord-285335-agm4zbcx 71 10 one one CD cord-285335-agm4zbcx 71 11 another another DT cord-285335-agm4zbcx 71 12 and and CC cord-285335-agm4zbcx 71 13 form form VB cord-285335-agm4zbcx 71 14 a a DT cord-285335-agm4zbcx 71 15 closely closely RB cord-285335-agm4zbcx 71 16 related related JJ cord-285335-agm4zbcx 71 17 cluster cluster NN cord-285335-agm4zbcx 71 18 . . . cord-285335-agm4zbcx 72 1 We -PRON- PRP cord-285335-agm4zbcx 72 2 have have VBP cord-285335-agm4zbcx 72 3 characterized characterize VBN cord-285335-agm4zbcx 72 4 the the DT cord-285335-agm4zbcx 72 5 7a/7b 7a/7b CD cord-285335-agm4zbcx 72 6 ORF ORF NNP cord-285335-agm4zbcx 72 7 of of IN cord-285335-agm4zbcx 72 8 FCoV FCoV NNP cord-285335-agm4zbcx 72 9 variants variant NNS cord-285335-agm4zbcx 72 10 in in IN cord-285335-agm4zbcx 72 11 a a DT cord-285335-agm4zbcx 72 12 population population NN cord-285335-agm4zbcx 72 13 experiencing experience VBG cord-285335-agm4zbcx 72 14 an an DT cord-285335-agm4zbcx 72 15 epidemic epidemic NN cord-285335-agm4zbcx 72 16 of of IN cord-285335-agm4zbcx 72 17 FIP FIP NNP cord-285335-agm4zbcx 72 18 . . . cord-285335-agm4zbcx 73 1 One one CD cord-285335-agm4zbcx 73 2 variant variant NN cord-285335-agm4zbcx 73 3 had have VBD cord-285335-agm4zbcx 73 4 an an DT cord-285335-agm4zbcx 73 5 intact intact JJ cord-285335-agm4zbcx 73 6 7a/7b 7a/7b CD cord-285335-agm4zbcx 73 7 ORF ORF NNP cord-285335-agm4zbcx 73 8 , , , cord-285335-agm4zbcx 73 9 while while IN cord-285335-agm4zbcx 73 10 another another DT cord-285335-agm4zbcx 73 11 had have VBD cord-285335-agm4zbcx 73 12 two two CD cord-285335-agm4zbcx 73 13 major major JJ cord-285335-agm4zbcx 73 14 deletions deletion NNS cord-285335-agm4zbcx 73 15 in in IN cord-285335-agm4zbcx 73 16 the the DT cord-285335-agm4zbcx 73 17 7a 7a NN cord-285335-agm4zbcx 73 18 ORF ORF NNP cord-285335-agm4zbcx 73 19 . . . cord-285335-agm4zbcx 74 1 The the DT cord-285335-agm4zbcx 74 2 latter latter JJ cord-285335-agm4zbcx 74 3 group group NN cord-285335-agm4zbcx 74 4 appears appear VBZ cord-285335-agm4zbcx 74 5 to to TO cord-285335-agm4zbcx 74 6 be be VB cord-285335-agm4zbcx 74 7 very very RB cord-285335-agm4zbcx 74 8 closely closely RB cord-285335-agm4zbcx 74 9 related related JJ cord-285335-agm4zbcx 74 10 , , , cord-285335-agm4zbcx 74 11 and and CC cord-285335-agm4zbcx 74 12 probably probably RB cord-285335-agm4zbcx 74 13 arose arise VBD cord-285335-agm4zbcx 74 14 from from IN cord-285335-agm4zbcx 74 15 a a DT cord-285335-agm4zbcx 74 16 single single JJ cord-285335-agm4zbcx 74 17 mutant mutant JJ cord-285335-agm4zbcx 74 18 strain strain NN cord-285335-agm4zbcx 74 19 . . . cord-285335-agm4zbcx 75 1 The the DT cord-285335-agm4zbcx 75 2 first first JJ cord-285335-agm4zbcx 75 3 deletion deletion NN cord-285335-agm4zbcx 75 4 resulted result VBD cord-285335-agm4zbcx 75 5 in in IN cord-285335-agm4zbcx 75 6 no no DT cord-285335-agm4zbcx 75 7 change change NN cord-285335-agm4zbcx 75 8 in in IN cord-285335-agm4zbcx 75 9 the the DT cord-285335-agm4zbcx 75 10 reading reading NN cord-285335-agm4zbcx 75 11 frame frame NN cord-285335-agm4zbcx 75 12 , , , cord-285335-agm4zbcx 75 13 but but CC cord-285335-agm4zbcx 75 14 the the DT cord-285335-agm4zbcx 75 15 second second JJ cord-285335-agm4zbcx 75 16 deletion deletion NN cord-285335-agm4zbcx 75 17 led lead VBD cord-285335-agm4zbcx 75 18 to to IN cord-285335-agm4zbcx 75 19 an an DT cord-285335-agm4zbcx 75 20 alteration alteration NN cord-285335-agm4zbcx 75 21 of of IN cord-285335-agm4zbcx 75 22 the the DT cord-285335-agm4zbcx 75 23 reading reading NN cord-285335-agm4zbcx 75 24 frame frame NN cord-285335-agm4zbcx 75 25 by by IN cord-285335-agm4zbcx 75 26 one one CD cord-285335-agm4zbcx 75 27 nucleotide nucleotide NN cord-285335-agm4zbcx 75 28 leading lead VBG cord-285335-agm4zbcx 75 29 to to IN cord-285335-agm4zbcx 75 30 an an DT cord-285335-agm4zbcx 75 31 altered alter VBN cord-285335-agm4zbcx 75 32 amino amino NN cord-285335-agm4zbcx 75 33 acid acid NN cord-285335-agm4zbcx 75 34 sequence sequence NN cord-285335-agm4zbcx 75 35 in in IN cord-285335-agm4zbcx 75 36 the the DT cord-285335-agm4zbcx 75 37 predicted predict VBN cord-285335-agm4zbcx 75 38 protein protein NN cord-285335-agm4zbcx 75 39 . . . cord-285335-agm4zbcx 76 1 We -PRON- PRP cord-285335-agm4zbcx 76 2 speculate speculate VBP cord-285335-agm4zbcx 76 3 that that IN cord-285335-agm4zbcx 76 4 these these DT cord-285335-agm4zbcx 76 5 deletions deletion NNS cord-285335-agm4zbcx 76 6 arose arise VBD cord-285335-agm4zbcx 76 7 from from IN cord-285335-agm4zbcx 76 8 ' ' '' cord-285335-agm4zbcx 76 9 ' ' `` cord-285335-agm4zbcx 76 10 looping loop VBG cord-285335-agm4zbcx 76 11 out out RP cord-285335-agm4zbcx 76 12 ' ' '' cord-285335-agm4zbcx 76 13 ' ' '' cord-285335-agm4zbcx 76 14 of of IN cord-285335-agm4zbcx 76 15 RNA RNA NNP cord-285335-agm4zbcx 76 16 regions region NNS cord-285335-agm4zbcx 76 17 due due JJ cord-285335-agm4zbcx 76 18 to to IN cord-285335-agm4zbcx 76 19 the the DT cord-285335-agm4zbcx 76 20 predicted predict VBN cord-285335-agm4zbcx 76 21 secondary secondary JJ cord-285335-agm4zbcx 76 22 structure structure NN cord-285335-agm4zbcx 76 23 of of IN cord-285335-agm4zbcx 76 24 the the DT cord-285335-agm4zbcx 76 25 single single JJ cord-285335-agm4zbcx 76 26 stranded strand VBN cord-285335-agm4zbcx 76 27 RNA RNA NNP cord-285335-agm4zbcx 76 28 genome genome NN cord-285335-agm4zbcx 76 29 in in IN cord-285335-agm4zbcx 76 30 this this DT cord-285335-agm4zbcx 76 31 region region NN cord-285335-agm4zbcx 76 32 ( ( -LRB- cord-285335-agm4zbcx 76 33 data datum NNS cord-285335-agm4zbcx 76 34 not not RB cord-285335-agm4zbcx 76 35 shown show VBN cord-285335-agm4zbcx 76 36 ) ) -RRB- cord-285335-agm4zbcx 76 37 . . . cord-285335-agm4zbcx 77 1 This this DT cord-285335-agm4zbcx 77 2 may may MD cord-285335-agm4zbcx 77 3 result result VB cord-285335-agm4zbcx 77 4 in in IN cord-285335-agm4zbcx 77 5 the the DT cord-285335-agm4zbcx 77 6 viral viral JJ cord-285335-agm4zbcx 77 7 RNA RNA NNP cord-285335-agm4zbcx 77 8 polymerase polymerase NN cord-285335-agm4zbcx 77 9 ' ' '' cord-285335-agm4zbcx 77 10 ' ' '' cord-285335-agm4zbcx 77 11 skipping skip VBG cord-285335-agm4zbcx 77 12 ' ' '' cord-285335-agm4zbcx 77 13 ' ' '' cord-285335-agm4zbcx 77 14 certain certain JJ cord-285335-agm4zbcx 77 15 regions region NNS cord-285335-agm4zbcx 77 16 during during IN cord-285335-agm4zbcx 77 17 transcription transcription NN cord-285335-agm4zbcx 77 18 . . . cord-285335-agm4zbcx 78 1 It -PRON- PRP cord-285335-agm4zbcx 78 2 is be VBZ cord-285335-agm4zbcx 78 3 not not RB cord-285335-agm4zbcx 78 4 known know VBN cord-285335-agm4zbcx 78 5 if if IN cord-285335-agm4zbcx 78 6 the the DT cord-285335-agm4zbcx 78 7 7a 7a NN cord-285335-agm4zbcx 78 8 protein protein NN cord-285335-agm4zbcx 78 9 is be VBZ cord-285335-agm4zbcx 78 10 expressed express VBN cord-285335-agm4zbcx 78 11 in in IN cord-285335-agm4zbcx 78 12 the the DT cord-285335-agm4zbcx 78 13 mutant mutant JJ cord-285335-agm4zbcx 78 14 virus virus NN cord-285335-agm4zbcx 78 15 . . . cord-285335-agm4zbcx 79 1 The the DT cord-285335-agm4zbcx 79 2 first first JJ cord-285335-agm4zbcx 79 3 18 18 CD cord-285335-agm4zbcx 79 4 nucleotides nucleotide NNS cord-285335-agm4zbcx 79 5 of of IN cord-285335-agm4zbcx 79 6 the the DT cord-285335-agm4zbcx 79 7 cDNA cdna NN cord-285335-agm4zbcx 79 8 sequence sequence NN cord-285335-agm4zbcx 79 9 , , , cord-285335-agm4zbcx 79 10 which which WDT cord-285335-agm4zbcx 79 11 corresponded correspond VBD cord-285335-agm4zbcx 79 12 to to IN cord-285335-agm4zbcx 79 13 nucleotides nucleotide NNS cord-285335-agm4zbcx 79 14 1 1 CD cord-285335-agm4zbcx 79 15 - - SYM cord-285335-agm4zbcx 79 16 18 18 CD cord-285335-agm4zbcx 79 17 of of IN cord-285335-agm4zbcx 79 18 the the DT cord-285335-agm4zbcx 79 19 7a 7a NN cord-285335-agm4zbcx 79 20 gene gene NN cord-285335-agm4zbcx 79 21 and and CC cord-285335-agm4zbcx 79 22 included include VBD cord-285335-agm4zbcx 79 23 the the DT cord-285335-agm4zbcx 79 24 start start NN cord-285335-agm4zbcx 79 25 codon codon NN cord-285335-agm4zbcx 79 26 , , , cord-285335-agm4zbcx 79 27 corresponded correspond VBD cord-285335-agm4zbcx 79 28 to to IN cord-285335-agm4zbcx 79 29 the the DT cord-285335-agm4zbcx 79 30 upstream upstream JJ cord-285335-agm4zbcx 79 31 internal internal JJ cord-285335-agm4zbcx 79 32 primer primer NN cord-285335-agm4zbcx 79 33 . . . cord-285335-agm4zbcx 80 1 Some some DT cord-285335-agm4zbcx 80 2 of of IN cord-285335-agm4zbcx 80 3 these these DT cord-285335-agm4zbcx 80 4 nucleotides nucleotide NNS cord-285335-agm4zbcx 80 5 must must MD cord-285335-agm4zbcx 80 6 be be VB cord-285335-agm4zbcx 80 7 present present JJ cord-285335-agm4zbcx 80 8 in in IN cord-285335-agm4zbcx 80 9 the the DT cord-285335-agm4zbcx 80 10 viral viral JJ cord-285335-agm4zbcx 80 11 template template NN cord-285335-agm4zbcx 80 12 in in IN cord-285335-agm4zbcx 80 13 order order NN cord-285335-agm4zbcx 80 14 for for IN cord-285335-agm4zbcx 80 15 hybridization hybridization NN cord-285335-agm4zbcx 80 16 of of IN cord-285335-agm4zbcx 80 17 primer primer NN cord-285335-agm4zbcx 80 18 to to IN cord-285335-agm4zbcx 80 19 template template NN cord-285335-agm4zbcx 80 20 to to TO cord-285335-agm4zbcx 80 21 occur occur VB cord-285335-agm4zbcx 80 22 but but CC cord-285335-agm4zbcx 80 23 it -PRON- PRP cord-285335-agm4zbcx 80 24 is be VBZ cord-285335-agm4zbcx 80 25 not not RB cord-285335-agm4zbcx 80 26 known know VBN cord-285335-agm4zbcx 80 27 how how WRB cord-285335-agm4zbcx 80 28 many many JJ cord-285335-agm4zbcx 80 29 of of IN cord-285335-agm4zbcx 80 30 nucleotides nucleotide NNS cord-285335-agm4zbcx 80 31 1 1 CD cord-285335-agm4zbcx 80 32 - - SYM cord-285335-agm4zbcx 80 33 18 18 CD cord-285335-agm4zbcx 80 34 are be VBP cord-285335-agm4zbcx 80 35 present present JJ cord-285335-agm4zbcx 80 36 in in IN cord-285335-agm4zbcx 80 37 the the DT cord-285335-agm4zbcx 80 38 virus virus NN cord-285335-agm4zbcx 80 39 . . . cord-285335-agm4zbcx 81 1 Thus thus RB cord-285335-agm4zbcx 81 2 , , , cord-285335-agm4zbcx 81 3 it -PRON- PRP cord-285335-agm4zbcx 81 4 is be VBZ cord-285335-agm4zbcx 81 5 unclear unclear JJ cord-285335-agm4zbcx 81 6 if if IN cord-285335-agm4zbcx 81 7 this this DT cord-285335-agm4zbcx 81 8 start start NN cord-285335-agm4zbcx 81 9 codon codon NN cord-285335-agm4zbcx 81 10 is be VBZ cord-285335-agm4zbcx 81 11 present present JJ cord-285335-agm4zbcx 81 12 . . . cord-285335-agm4zbcx 82 1 If if IN cord-285335-agm4zbcx 82 2 it -PRON- PRP cord-285335-agm4zbcx 82 3 is be VBZ cord-285335-agm4zbcx 82 4 , , , cord-285335-agm4zbcx 82 5 translation translation NN cord-285335-agm4zbcx 82 6 of of IN cord-285335-agm4zbcx 82 7 the the DT cord-285335-agm4zbcx 82 8 7a 7a NN cord-285335-agm4zbcx 82 9 ORF ORF NNP cord-285335-agm4zbcx 82 10 in in IN cord-285335-agm4zbcx 82 11 the the DT cord-285335-agm4zbcx 82 12 deletion deletion NN cord-285335-agm4zbcx 82 13 mutant mutant NN cord-285335-agm4zbcx 82 14 would would MD cord-285335-agm4zbcx 82 15 result result VB cord-285335-agm4zbcx 82 16 in in IN cord-285335-agm4zbcx 82 17 a a DT cord-285335-agm4zbcx 82 18 predicted predict VBN cord-285335-agm4zbcx 82 19 protein protein NN cord-285335-agm4zbcx 82 20 that that WDT cord-285335-agm4zbcx 82 21 is be VBZ cord-285335-agm4zbcx 82 22 nearly nearly RB cord-285335-agm4zbcx 82 23 half half PDT cord-285335-agm4zbcx 82 24 the the DT cord-285335-agm4zbcx 82 25 size size NN cord-285335-agm4zbcx 82 26 of of IN cord-285335-agm4zbcx 82 27 the the DT cord-285335-agm4zbcx 82 28 native native JJ cord-285335-agm4zbcx 82 29 protein protein NN cord-285335-agm4zbcx 82 30 ( ( -LRB- cord-285335-agm4zbcx 82 31 58 58 CD cord-285335-agm4zbcx 82 32 amino amino JJ cord-285335-agm4zbcx 82 33 acids acid NNS cord-285335-agm4zbcx 82 34 in in IN cord-285335-agm4zbcx 82 35 deletion deletion NN cord-285335-agm4zbcx 82 36 mutant mutant NN cord-285335-agm4zbcx 82 37 versus versus IN cord-285335-agm4zbcx 82 38 108 108 CD cord-285335-agm4zbcx 82 39 amino amino JJ cord-285335-agm4zbcx 82 40 acids acid NNS cord-285335-agm4zbcx 82 41 residues residue NNS cord-285335-agm4zbcx 82 42 in in IN cord-285335-agm4zbcx 82 43 the the DT cord-285335-agm4zbcx 82 44 native native JJ cord-285335-agm4zbcx 82 45 virus virus NN cord-285335-agm4zbcx 82 46 ) ) -RRB- cord-285335-agm4zbcx 82 47 . . . cord-285335-agm4zbcx 83 1 The the DT cord-285335-agm4zbcx 83 2 sire sire NN cord-285335-agm4zbcx 83 3 of of IN cord-285335-agm4zbcx 83 4 the the DT cord-285335-agm4zbcx 83 5 majority majority NN cord-285335-agm4zbcx 83 6 of of IN cord-285335-agm4zbcx 83 7 FIP FIP NNP cord-285335-agm4zbcx 83 8 kittens kitten NNS cord-285335-agm4zbcx 83 9 was be VBD cord-285335-agm4zbcx 83 10 dually dually RB cord-285335-agm4zbcx 83 11 infected infect VBN cord-285335-agm4zbcx 83 12 with with IN cord-285335-agm4zbcx 83 13 both both DT cord-285335-agm4zbcx 83 14 virus virus NN cord-285335-agm4zbcx 83 15 variants variant NNS cord-285335-agm4zbcx 83 16 as as IN cord-285335-agm4zbcx 83 17 revealed reveal VBN cord-285335-agm4zbcx 83 18 by by IN cord-285335-agm4zbcx 83 19 sequence sequence NN cord-285335-agm4zbcx 83 20 analysis analysis NN cord-285335-agm4zbcx 83 21 of of IN cord-285335-agm4zbcx 83 22 cloned clone VBN cord-285335-agm4zbcx 83 23 7a/7b 7a/7b CD cord-285335-agm4zbcx 83 24 genes gene NNS cord-285335-agm4zbcx 83 25 from from IN cord-285335-agm4zbcx 83 26 this this DT cord-285335-agm4zbcx 83 27 cat cat NN cord-285335-agm4zbcx 83 28 . . . cord-285335-agm4zbcx 84 1 Other other JJ cord-285335-agm4zbcx 84 2 cats cat NNS cord-285335-agm4zbcx 84 3 in in IN cord-285335-agm4zbcx 84 4 this this DT cord-285335-agm4zbcx 84 5 study study NN cord-285335-agm4zbcx 84 6 may may MD cord-285335-agm4zbcx 84 7 have have VB cord-285335-agm4zbcx 84 8 also also RB cord-285335-agm4zbcx 84 9 been be VBN cord-285335-agm4zbcx 84 10 dually dually RB cord-285335-agm4zbcx 84 11 infected infect VBN cord-285335-agm4zbcx 84 12 with with IN cord-285335-agm4zbcx 84 13 both both DT cord-285335-agm4zbcx 84 14 virus virus NN cord-285335-agm4zbcx 84 15 variants variant NNS cord-285335-agm4zbcx 84 16 , , , cord-285335-agm4zbcx 84 17 however however RB cord-285335-agm4zbcx 84 18 , , , cord-285335-agm4zbcx 84 19 only only RB cord-285335-agm4zbcx 84 20 one one CD cord-285335-agm4zbcx 84 21 virus virus NN cord-285335-agm4zbcx 84 22 variant variant NN cord-285335-agm4zbcx 84 23 was be VBD cord-285335-agm4zbcx 84 24 identified identify VBN cord-285335-agm4zbcx 84 25 by by IN cord-285335-agm4zbcx 84 26 PCR PCR NNP cord-285335-agm4zbcx 84 27 in in IN cord-285335-agm4zbcx 84 28 each each DT cord-285335-agm4zbcx 84 29 of of IN cord-285335-agm4zbcx 84 30 the the DT cord-285335-agm4zbcx 84 31 remaining remain VBG cord-285335-agm4zbcx 84 32 cats cat NNS cord-285335-agm4zbcx 84 33 tested test VBN cord-285335-agm4zbcx 84 34 . . . cord-285335-agm4zbcx 85 1 This this DT cord-285335-agm4zbcx 85 2 may may MD cord-285335-agm4zbcx 85 3 be be VB cord-285335-agm4zbcx 85 4 due due JJ cord-285335-agm4zbcx 85 5 to to IN cord-285335-agm4zbcx 85 6 a a DT cord-285335-agm4zbcx 85 7 quantitative quantitative JJ cord-285335-agm4zbcx 85 8 difference difference NN cord-285335-agm4zbcx 85 9 in in IN cord-285335-agm4zbcx 85 10 the the DT cord-285335-agm4zbcx 85 11 amount amount NN cord-285335-agm4zbcx 85 12 of of IN cord-285335-agm4zbcx 85 13 each each DT cord-285335-agm4zbcx 85 14 virus virus NN cord-285335-agm4zbcx 85 15 variant variant NN cord-285335-agm4zbcx 85 16 in in IN cord-285335-agm4zbcx 85 17 each each DT cord-285335-agm4zbcx 85 18 cat cat NN cord-285335-agm4zbcx 85 19 tested test VBN cord-285335-agm4zbcx 85 20 . . . cord-285335-agm4zbcx 86 1 Both both DT cord-285335-agm4zbcx 86 2 variants variant NNS cord-285335-agm4zbcx 86 3 were be VBD cord-285335-agm4zbcx 86 4 circulating circulate VBG cord-285335-agm4zbcx 86 5 as as IN cord-285335-agm4zbcx 86 6 every every DT cord-285335-agm4zbcx 86 7 cat cat NN cord-285335-agm4zbcx 86 8 tested test VBN cord-285335-agm4zbcx 86 9 was be VBD cord-285335-agm4zbcx 86 10 infected infect VBN cord-285335-agm4zbcx 86 11 with with IN cord-285335-agm4zbcx 86 12 one one CD cord-285335-agm4zbcx 86 13 of of IN cord-285335-agm4zbcx 86 14 the the DT cord-285335-agm4zbcx 86 15 virus virus NN cord-285335-agm4zbcx 86 16 variants variant NNS cord-285335-agm4zbcx 86 17 . . . cord-285335-agm4zbcx 87 1 Some some DT cord-285335-agm4zbcx 87 2 infected infect VBN cord-285335-agm4zbcx 87 3 with with IN cord-285335-agm4zbcx 87 4 the the DT cord-285335-agm4zbcx 87 5 intact intact JJ cord-285335-agm4zbcx 87 6 7a/7b 7a/7b CD cord-285335-agm4zbcx 87 7 ORF ORF NNP cord-285335-agm4zbcx 87 8 variant variant NN cord-285335-agm4zbcx 87 9 were be VBD cord-285335-agm4zbcx 87 10 ill ill JJ cord-285335-agm4zbcx 87 11 and and CC cord-285335-agm4zbcx 87 12 some some DT cord-285335-agm4zbcx 87 13 infected infect VBN cord-285335-agm4zbcx 87 14 with with IN cord-285335-agm4zbcx 87 15 the the DT cord-285335-agm4zbcx 87 16 deletion deletion NN cord-285335-agm4zbcx 87 17 mutant mutant NN cord-285335-agm4zbcx 87 18 were be VBD cord-285335-agm4zbcx 87 19 ill ill JJ cord-285335-agm4zbcx 87 20 . . . cord-285335-agm4zbcx 88 1 However however RB cord-285335-agm4zbcx 88 2 , , , cord-285335-agm4zbcx 88 3 as as IN cord-285335-agm4zbcx 88 4 both both DT cord-285335-agm4zbcx 88 5 variants variant NNS cord-285335-agm4zbcx 88 6 were be VBD cord-285335-agm4zbcx 88 7 circulating circulate VBG cord-285335-agm4zbcx 88 8 and and CC cord-285335-agm4zbcx 88 9 thus thus RB cord-285335-agm4zbcx 88 10 , , , cord-285335-agm4zbcx 88 11 every every DT cord-285335-agm4zbcx 88 12 cat cat NN cord-285335-agm4zbcx 88 13 was be VBD cord-285335-agm4zbcx 88 14 exposed expose VBN cord-285335-agm4zbcx 88 15 to to IN cord-285335-agm4zbcx 88 16 both both DT cord-285335-agm4zbcx 88 17 variants variant NNS cord-285335-agm4zbcx 88 18 , , , cord-285335-agm4zbcx 88 19 there there EX cord-285335-agm4zbcx 88 20 may may MD cord-285335-agm4zbcx 88 21 be be VB cord-285335-agm4zbcx 88 22 a a DT cord-285335-agm4zbcx 88 23 causal causal JJ cord-285335-agm4zbcx 88 24 relationship relationship NN cord-285335-agm4zbcx 88 25 between between IN cord-285335-agm4zbcx 88 26 the the DT cord-285335-agm4zbcx 88 27 mutation mutation NN cord-285335-agm4zbcx 88 28 that that WDT cord-285335-agm4zbcx 88 29 occurred occur VBD cord-285335-agm4zbcx 88 30 and and CC cord-285335-agm4zbcx 88 31 the the DT cord-285335-agm4zbcx 88 32 increased increase VBN cord-285335-agm4zbcx 88 33 incidence incidence NN cord-285335-agm4zbcx 88 34 of of IN cord-285335-agm4zbcx 88 35 disease disease NN cord-285335-agm4zbcx 88 36 seen see VBN cord-285335-agm4zbcx 88 37 in in IN cord-285335-agm4zbcx 88 38 this this DT cord-285335-agm4zbcx 88 39 population population NN cord-285335-agm4zbcx 88 40 . . . cord-285335-agm4zbcx 89 1 The the DT cord-285335-agm4zbcx 89 2 variation variation NN cord-285335-agm4zbcx 89 3 in in IN cord-285335-agm4zbcx 89 4 disease disease NN cord-285335-agm4zbcx 89 5 may may MD cord-285335-agm4zbcx 89 6 be be VB cord-285335-agm4zbcx 89 7 related relate VBN cord-285335-agm4zbcx 89 8 to to IN cord-285335-agm4zbcx 89 9 host host NN cord-285335-agm4zbcx 89 10 factors factor NNS cord-285335-agm4zbcx 89 11 , , , cord-285335-agm4zbcx 89 12 such such JJ cord-285335-agm4zbcx 89 13 as as IN cord-285335-agm4zbcx 89 14 generation generation NN cord-285335-agm4zbcx 89 15 of of IN cord-285335-agm4zbcx 89 16 an an DT cord-285335-agm4zbcx 89 17 effective effective JJ cord-285335-agm4zbcx 89 18 immune immune JJ cord-285335-agm4zbcx 89 19 response response NN cord-285335-agm4zbcx 89 20 , , , cord-285335-agm4zbcx 89 21 rather rather RB cord-285335-agm4zbcx 89 22 than than IN cord-285335-agm4zbcx 89 23 solely solely RB cord-285335-agm4zbcx 89 24 to to IN cord-285335-agm4zbcx 89 25 the the DT cord-285335-agm4zbcx 89 26 virus virus NN cord-285335-agm4zbcx 89 27 itself -PRON- PRP cord-285335-agm4zbcx 89 28 . . . cord-285335-agm4zbcx 90 1 Alternatively alternatively RB cord-285335-agm4zbcx 90 2 , , , cord-285335-agm4zbcx 90 3 mutations mutation NNS cord-285335-agm4zbcx 90 4 in in IN cord-285335-agm4zbcx 90 5 other other JJ cord-285335-agm4zbcx 90 6 genomic genomic JJ cord-285335-agm4zbcx 90 7 regions region NNS cord-285335-agm4zbcx 90 8 may may MD cord-285335-agm4zbcx 90 9 be be VB cord-285335-agm4zbcx 90 10 responsible responsible JJ cord-285335-agm4zbcx 90 11 for for IN cord-285335-agm4zbcx 90 12 the the DT cord-285335-agm4zbcx 90 13 variation variation NN cord-285335-agm4zbcx 90 14 in in IN cord-285335-agm4zbcx 90 15 virulence virulence NN cord-285335-agm4zbcx 90 16 observed observe VBN cord-285335-agm4zbcx 90 17 with with IN cord-285335-agm4zbcx 90 18 these these DT cord-285335-agm4zbcx 90 19 isolates isolate NNS cord-285335-agm4zbcx 90 20 . . . cord-285335-agm4zbcx 91 1 Host host NN cord-285335-agm4zbcx 91 2 factors factor NNS cord-285335-agm4zbcx 91 3 may may MD cord-285335-agm4zbcx 91 4 play play VB cord-285335-agm4zbcx 91 5 an an DT cord-285335-agm4zbcx 91 6 important important JJ cord-285335-agm4zbcx 91 7 role role NN cord-285335-agm4zbcx 91 8 in in IN cord-285335-agm4zbcx 91 9 the the DT cord-285335-agm4zbcx 91 10 virulence virulence NN cord-285335-agm4zbcx 91 11 of of IN cord-285335-agm4zbcx 91 12 FCoV. fcov. NN cord-285335-agm4zbcx 91 13 Increased increase VBN cord-285335-agm4zbcx 91 14 incidence incidence NN cord-285335-agm4zbcx 91 15 of of IN cord-285335-agm4zbcx 91 16 FIP fip NN cord-285335-agm4zbcx 91 17 in in IN cord-285335-agm4zbcx 91 18 purebred purebred JJ cord-285335-agm4zbcx 91 19 cats cat NNS cord-285335-agm4zbcx 91 20 , , , cord-285335-agm4zbcx 91 21 as as RB cord-285335-agm4zbcx 91 22 well well RB cord-285335-agm4zbcx 91 23 as as IN cord-285335-agm4zbcx 91 24 in in IN cord-285335-agm4zbcx 91 25 cheetahs cheetah NNS cord-285335-agm4zbcx 91 26 , , , cord-285335-agm4zbcx 91 27 which which WDT cord-285335-agm4zbcx 91 28 are be VBP cord-285335-agm4zbcx 91 29 relatively relatively RB cord-285335-agm4zbcx 91 30 genetically genetically RB cord-285335-agm4zbcx 91 31 homologous homologous JJ cord-285335-agm4zbcx 91 32 , , , cord-285335-agm4zbcx 91 33 is be VBZ cord-285335-agm4zbcx 91 34 known know VBN cord-285335-agm4zbcx 91 35 to to TO cord-285335-agm4zbcx 91 36 occur occur VB cord-285335-agm4zbcx 92 1 ( ( -LRB- cord-285335-agm4zbcx 92 2 O'Brien O'Brien NNP cord-285335-agm4zbcx 92 3 et et NNP cord-285335-agm4zbcx 92 4 al al NNP cord-285335-agm4zbcx 92 5 . . . cord-285335-agm4zbcx 93 1 , , , cord-285335-agm4zbcx 93 2 1985 1985 CD cord-285335-agm4zbcx 93 3 ; ; : cord-285335-agm4zbcx 93 4 Foley Foley NNP cord-285335-agm4zbcx 93 5 and and CC cord-285335-agm4zbcx 93 6 Pedersen Pedersen NNP cord-285335-agm4zbcx 93 7 , , , cord-285335-agm4zbcx 93 8 1996 1996 CD cord-285335-agm4zbcx 93 9 ) ) -RRB- cord-285335-agm4zbcx 93 10 . . . cord-285335-agm4zbcx 94 1 In in IN cord-285335-agm4zbcx 94 2 this this DT cord-285335-agm4zbcx 94 3 investigation investigation NN cord-285335-agm4zbcx 94 4 , , , cord-285335-agm4zbcx 94 5 all all DT cord-285335-agm4zbcx 94 6 of of IN cord-285335-agm4zbcx 94 7 the the DT cord-285335-agm4zbcx 94 8 FIP FIP NNP cord-285335-agm4zbcx 94 9 victims victim NNS cord-285335-agm4zbcx 94 10 were be VBD cord-285335-agm4zbcx 94 11 genetically genetically RB cord-285335-agm4zbcx 94 12 related relate VBN cord-285335-agm4zbcx 94 13 through through IN cord-285335-agm4zbcx 94 14 the the DT cord-285335-agm4zbcx 94 15 sire sire NN cord-285335-agm4zbcx 94 16 . . . cord-285335-agm4zbcx 95 1 Those those DT cord-285335-agm4zbcx 95 2 related related JJ cord-285335-agm4zbcx 95 3 to to IN cord-285335-agm4zbcx 95 4 him -PRON- PRP cord-285335-agm4zbcx 95 5 through through IN cord-285335-agm4zbcx 95 6 both both CC cord-285335-agm4zbcx 95 7 the the DT cord-285335-agm4zbcx 95 8 queen queen NN cord-285335-agm4zbcx 95 9 and and CC cord-285335-agm4zbcx 95 10 sire sire NN cord-285335-agm4zbcx 95 11 had have VBD cord-285335-agm4zbcx 95 12 the the DT cord-285335-agm4zbcx 95 13 highest high JJS cord-285335-agm4zbcx 95 14 morbidity morbidity NN cord-285335-agm4zbcx 95 15 while while IN cord-285335-agm4zbcx 95 16 those those DT cord-285335-agm4zbcx 95 17 related relate VBN cord-285335-agm4zbcx 95 18 to to IN cord-285335-agm4zbcx 95 19 him -PRON- PRP cord-285335-agm4zbcx 95 20 through through IN cord-285335-agm4zbcx 95 21 the the DT cord-285335-agm4zbcx 95 22 queen queen NN cord-285335-agm4zbcx 95 23 or or CC cord-285335-agm4zbcx 95 24 sire sire NN cord-285335-agm4zbcx 95 25 only only RB cord-285335-agm4zbcx 95 26 had have VBD cord-285335-agm4zbcx 95 27 lower low JJR cord-285335-agm4zbcx 95 28 morbidity morbidity NN cord-285335-agm4zbcx 95 29 . . . cord-285335-agm4zbcx 96 1 This this DT cord-285335-agm4zbcx 96 2 would would MD cord-285335-agm4zbcx 96 3 support support VB cord-285335-agm4zbcx 96 4 the the DT cord-285335-agm4zbcx 96 5 belief belief NN cord-285335-agm4zbcx 96 6 that that IN cord-285335-agm4zbcx 96 7 susceptibility susceptibility NN cord-285335-agm4zbcx 96 8 to to IN cord-285335-agm4zbcx 96 9 FIP fip NN cord-285335-agm4zbcx 96 10 following follow VBG cord-285335-agm4zbcx 96 11 infection infection NN cord-285335-agm4zbcx 96 12 with with IN cord-285335-agm4zbcx 96 13 FCoV FCoV NNP cord-285335-agm4zbcx 96 14 has have VBZ cord-285335-agm4zbcx 96 15 a a DT cord-285335-agm4zbcx 96 16 host host NN cord-285335-agm4zbcx 96 17 genetic genetic JJ cord-285335-agm4zbcx 96 18 component component NN cord-285335-agm4zbcx 96 19 . . . cord-285335-agm4zbcx 97 1 Genetic genetic JJ cord-285335-agm4zbcx 97 2 detection detection NN cord-285335-agm4zbcx 97 3 targeting target VBG cord-285335-agm4zbcx 97 4 the the DT cord-285335-agm4zbcx 97 5 7a/7b 7a/7b CD cord-285335-agm4zbcx 97 6 ORF ORF NNP cord-285335-agm4zbcx 97 7 of of IN cord-285335-agm4zbcx 97 8 FCoV FCoV NNP cord-285335-agm4zbcx 97 9 was be VBD cord-285335-agm4zbcx 97 10 not not RB cord-285335-agm4zbcx 97 11 successful successful JJ cord-285335-agm4zbcx 97 12 in in IN cord-285335-agm4zbcx 97 13 all all DT cord-285335-agm4zbcx 97 14 FIP fip NN cord-285335-agm4zbcx 97 15 victims victim NNS cord-285335-agm4zbcx 97 16 . . . cord-285335-agm4zbcx 98 1 The the DT cord-285335-agm4zbcx 98 2 deletions deletion NNS cord-285335-agm4zbcx 98 3 we -PRON- PRP cord-285335-agm4zbcx 98 4 have have VBP cord-285335-agm4zbcx 98 5 characterized characterize VBN cord-285335-agm4zbcx 98 6 in in IN cord-285335-agm4zbcx 98 7 the the DT cord-285335-agm4zbcx 98 8 7a 7a NN cord-285335-agm4zbcx 98 9 ORF ORF NNP cord-285335-agm4zbcx 98 10 occurred occur VBD cord-285335-agm4zbcx 98 11 near near RB cord-285335-agm4zbcx 98 12 or or CC cord-285335-agm4zbcx 98 13 within within IN cord-285335-agm4zbcx 98 14 the the DT cord-285335-agm4zbcx 98 15 binding binding NN cord-285335-agm4zbcx 98 16 site site NN cord-285335-agm4zbcx 98 17 of of IN cord-285335-agm4zbcx 98 18 the the DT cord-285335-agm4zbcx 98 19 internal internal JJ cord-285335-agm4zbcx 98 20 upstream upstream JJ cord-285335-agm4zbcx 98 21 primer primer NN cord-285335-agm4zbcx 98 22 . . . cord-285335-agm4zbcx 99 1 As as IN cord-285335-agm4zbcx 99 2 the the DT cord-285335-agm4zbcx 99 3 virus virus NN cord-285335-agm4zbcx 99 4 has have VBZ cord-285335-agm4zbcx 99 5 persisted persist VBN cord-285335-agm4zbcx 99 6 in in IN cord-285335-agm4zbcx 99 7 this this DT cord-285335-agm4zbcx 99 8 population population NN cord-285335-agm4zbcx 99 9 , , , cord-285335-agm4zbcx 99 10 we -PRON- PRP cord-285335-agm4zbcx 99 11 postulate postulate VBP cord-285335-agm4zbcx 99 12 that that IN cord-285335-agm4zbcx 99 13 this this DT cord-285335-agm4zbcx 99 14 primer primer NN cord-285335-agm4zbcx 99 15 - - HYPH cord-285335-agm4zbcx 99 16 binding bind VBG cord-285335-agm4zbcx 99 17 site site NN cord-285335-agm4zbcx 99 18 may may MD cord-285335-agm4zbcx 99 19 have have VB cord-285335-agm4zbcx 99 20 been be VBN cord-285335-agm4zbcx 99 21 lost lose VBN cord-285335-agm4zbcx 99 22 due due IN cord-285335-agm4zbcx 99 23 to to IN cord-285335-agm4zbcx 99 24 the the DT cord-285335-agm4zbcx 99 25 occurrence occurrence NN cord-285335-agm4zbcx 99 26 of of IN cord-285335-agm4zbcx 99 27 additional additional JJ cord-285335-agm4zbcx 99 28 deletions deletion NNS cord-285335-agm4zbcx 99 29 in in IN cord-285335-agm4zbcx 99 30 the the DT cord-285335-agm4zbcx 99 31 7a 7a NN cord-285335-agm4zbcx 99 32 viral viral JJ cord-285335-agm4zbcx 99 33 gene gene NN cord-285335-agm4zbcx 99 34 . . . cord-285335-agm4zbcx 100 1 Mutation mutation NN cord-285335-agm4zbcx 100 2 of of IN cord-285335-agm4zbcx 100 3 FCoV FCoV NNP cord-285335-agm4zbcx 100 4 in in IN cord-285335-agm4zbcx 100 5 some some DT cord-285335-agm4zbcx 100 6 cats cat NNS cord-285335-agm4zbcx 100 7 may may MD cord-285335-agm4zbcx 100 8 lead lead VB cord-285335-agm4zbcx 100 9 to to IN cord-285335-agm4zbcx 100 10 changes change NNS cord-285335-agm4zbcx 100 11 in in IN cord-285335-agm4zbcx 100 12 virulence virulence NN cord-285335-agm4zbcx 100 13 ultimately ultimately RB cord-285335-agm4zbcx 100 14 resulting result VBG cord-285335-agm4zbcx 100 15 in in IN cord-285335-agm4zbcx 100 16 FIP FIP NNP cord-285335-agm4zbcx 100 17 . . . cord-285335-agm4zbcx 101 1 Point point NN cord-285335-agm4zbcx 101 2 mutations mutation NNS cord-285335-agm4zbcx 101 3 , , , cord-285335-agm4zbcx 101 4 recombination recombination NN cord-285335-agm4zbcx 101 5 , , , cord-285335-agm4zbcx 101 6 and and CC cord-285335-agm4zbcx 101 7 deletions deletion NNS cord-285335-agm4zbcx 101 8 have have VBP cord-285335-agm4zbcx 101 9 been be VBN cord-285335-agm4zbcx 101 10 observed observe VBN cord-285335-agm4zbcx 101 11 ( ( -LRB- cord-285335-agm4zbcx 101 12 Poland Poland NNP cord-285335-agm4zbcx 101 13 et et NNP cord-285335-agm4zbcx 101 14 al al NNP cord-285335-agm4zbcx 101 15 . . . cord-285335-agm4zbcx 102 1 , , , cord-285335-agm4zbcx 102 2 1996 1996 CD cord-285335-agm4zbcx 102 3 ; ; : cord-285335-agm4zbcx 102 4 Herrewegh Herrewegh NNP cord-285335-agm4zbcx 102 5 et et NNP cord-285335-agm4zbcx 102 6 al al NNP cord-285335-agm4zbcx 102 7 . . NNP cord-285335-agm4zbcx 102 8 , , , cord-285335-agm4zbcx 102 9 1995 1995 CD cord-285335-agm4zbcx 102 10 ) ) -RRB- cord-285335-agm4zbcx 102 11 . . . cord-285335-agm4zbcx 103 1 Mutations mutation NNS cord-285335-agm4zbcx 103 2 are be VBP cord-285335-agm4zbcx 103 3 more more RBR cord-285335-agm4zbcx 103 4 likely likely JJ cord-285335-agm4zbcx 103 5 to to TO cord-285335-agm4zbcx 103 6 occur occur VB cord-285335-agm4zbcx 103 7 if if IN cord-285335-agm4zbcx 103 8 virus virus NN cord-285335-agm4zbcx 103 9 is be VBZ cord-285335-agm4zbcx 103 10 not not RB cord-285335-agm4zbcx 103 11 cleared clear VBN cord-285335-agm4zbcx 103 12 from from IN cord-285335-agm4zbcx 103 13 a a DT cord-285335-agm4zbcx 103 14 host host NN cord-285335-agm4zbcx 103 15 population population NN cord-285335-agm4zbcx 103 16 and and CC cord-285335-agm4zbcx 103 17 viral viral JJ cord-285335-agm4zbcx 103 18 replication replication NN cord-285335-agm4zbcx 103 19 continues continue VBZ cord-285335-agm4zbcx 103 20 at at IN cord-285335-agm4zbcx 103 21 a a DT cord-285335-agm4zbcx 103 22 significant significant JJ cord-285335-agm4zbcx 103 23 level level NN cord-285335-agm4zbcx 103 24 . . . cord-285335-agm4zbcx 104 1 It -PRON- PRP cord-285335-agm4zbcx 104 2 is be VBZ cord-285335-agm4zbcx 104 3 not not RB cord-285335-agm4zbcx 104 4 known know VBN cord-285335-agm4zbcx 104 5 if if IN cord-285335-agm4zbcx 104 6 two two CD cord-285335-agm4zbcx 104 7 virus virus NN cord-285335-agm4zbcx 104 8 variants variant NNS cord-285335-agm4zbcx 104 9 entered enter VBD cord-285335-agm4zbcx 104 10 this this DT cord-285335-agm4zbcx 104 11 population population NN cord-285335-agm4zbcx 104 12 or or CC cord-285335-agm4zbcx 104 13 if if IN cord-285335-agm4zbcx 104 14 one one CD cord-285335-agm4zbcx 104 15 variant variant NN cord-285335-agm4zbcx 104 16 is be VBZ cord-285335-agm4zbcx 104 17 a a DT cord-285335-agm4zbcx 104 18 mutant mutant NN cord-285335-agm4zbcx 104 19 of of IN cord-285335-agm4zbcx 104 20 the the DT cord-285335-agm4zbcx 104 21 other other JJ cord-285335-agm4zbcx 104 22 . . . cord-285335-agm4zbcx 105 1 The the DT cord-285335-agm4zbcx 105 2 latter latter JJ cord-285335-agm4zbcx 105 3 may may MD cord-285335-agm4zbcx 105 4 be be VB cord-285335-agm4zbcx 105 5 more more RBR cord-285335-agm4zbcx 105 6 likely likely JJ cord-285335-agm4zbcx 105 7 , , , cord-285335-agm4zbcx 105 8 as as IN cord-285335-agm4zbcx 105 9 the the DT cord-285335-agm4zbcx 105 10 cats cat NNS cord-285335-agm4zbcx 105 11 in in IN cord-285335-agm4zbcx 105 12 this this DT cord-285335-agm4zbcx 105 13 population population NN cord-285335-agm4zbcx 105 14 have have VBP cord-285335-agm4zbcx 105 15 remained remain VBN cord-285335-agm4zbcx 105 16 virus virus NN cord-285335-agm4zbcx 105 17 - - HYPH cord-285335-agm4zbcx 105 18 infected infect VBN cord-285335-agm4zbcx 105 19 for for IN cord-285335-agm4zbcx 105 20 an an DT cord-285335-agm4zbcx 105 21 extensive extensive JJ cord-285335-agm4zbcx 105 22 period period NN cord-285335-agm4zbcx 105 23 increasing increase VBG cord-285335-agm4zbcx 105 24 the the DT cord-285335-agm4zbcx 105 25 likelihood likelihood NN cord-285335-agm4zbcx 105 26 of of IN cord-285335-agm4zbcx 105 27 genetic genetic JJ cord-285335-agm4zbcx 105 28 mutation mutation NN cord-285335-agm4zbcx 105 29 . . . cord-285335-agm4zbcx 106 1 Deletions deletion NNS cord-285335-agm4zbcx 106 2 have have VBP cord-285335-agm4zbcx 106 3 been be VBN cord-285335-agm4zbcx 106 4 noted note VBN cord-285335-agm4zbcx 106 5 in in IN cord-285335-agm4zbcx 106 6 the the DT cord-285335-agm4zbcx 106 7 7b 7b JJ cord-285335-agm4zbcx 106 8 ORF ORF NNP cord-285335-agm4zbcx 106 9 from from IN cord-285335-agm4zbcx 106 10 previous previous JJ cord-285335-agm4zbcx 106 11 studies study NNS cord-285335-agm4zbcx 106 12 ( ( -LRB- cord-285335-agm4zbcx 106 13 Vennema Vennema NNP cord-285335-agm4zbcx 106 14 et et FW cord-285335-agm4zbcx 106 15 al al NNP cord-285335-agm4zbcx 106 16 . . NNP cord-285335-agm4zbcx 106 17 , , , cord-285335-agm4zbcx 106 18 1995 1995 CD cord-285335-agm4zbcx 106 19 ) ) -RRB- cord-285335-agm4zbcx 106 20 . . . cord-285335-agm4zbcx 107 1 This this DT cord-285335-agm4zbcx 107 2 is be VBZ cord-285335-agm4zbcx 107 3 the the DT cord-285335-agm4zbcx 107 4 first first JJ cord-285335-agm4zbcx 107 5 report report NN cord-285335-agm4zbcx 107 6 of of IN cord-285335-agm4zbcx 107 7 a a DT cord-285335-agm4zbcx 107 8 deletion deletion NN cord-285335-agm4zbcx 107 9 occurring occur VBG cord-285335-agm4zbcx 107 10 in in IN cord-285335-agm4zbcx 107 11 the the DT cord-285335-agm4zbcx 107 12 7a 7a NN cord-285335-agm4zbcx 107 13 ORF ORF NNP cord-285335-agm4zbcx 107 14 in in IN cord-285335-agm4zbcx 107 15 a a DT cord-285335-agm4zbcx 107 16 natural natural JJ cord-285335-agm4zbcx 107 17 infection infection NN cord-285335-agm4zbcx 107 18 of of IN cord-285335-agm4zbcx 107 19 a a DT cord-285335-agm4zbcx 107 20 cat cat NN cord-285335-agm4zbcx 107 21 population population NN cord-285335-agm4zbcx 107 22 . . . cord-285335-agm4zbcx 108 1 Other other JJ cord-285335-agm4zbcx 108 2 virus virus NN cord-285335-agm4zbcx 108 3 mutations mutation NNS cord-285335-agm4zbcx 108 4 in in IN cord-285335-agm4zbcx 108 5 addition addition NN cord-285335-agm4zbcx 108 6 to to IN cord-285335-agm4zbcx 108 7 those those DT cord-285335-agm4zbcx 108 8 which which WDT cord-285335-agm4zbcx 108 9 we -PRON- PRP cord-285335-agm4zbcx 108 10 have have VBP cord-285335-agm4zbcx 108 11 characterized characterize VBN cord-285335-agm4zbcx 108 12 may may MD cord-285335-agm4zbcx 108 13 have have VB cord-285335-agm4zbcx 108 14 occurred occur VBN cord-285335-agm4zbcx 108 15 in in IN cord-285335-agm4zbcx 108 16 the the DT cord-285335-agm4zbcx 108 17 FCoV FCoV NNP cord-285335-agm4zbcx 108 18 from from IN cord-285335-agm4zbcx 108 19 this this DT cord-285335-agm4zbcx 108 20 population population NN cord-285335-agm4zbcx 108 21 and and CC cord-285335-agm4zbcx 108 22 may may MD cord-285335-agm4zbcx 108 23 correlate correlate VB cord-285335-agm4zbcx 108 24 directly directly RB cord-285335-agm4zbcx 108 25 with with IN cord-285335-agm4zbcx 108 26 virulence virulence NN cord-285335-agm4zbcx 108 27 . . . cord-285335-agm4zbcx 109 1 Further further JJ cord-285335-agm4zbcx 109 2 analysis analysis NN cord-285335-agm4zbcx 109 3 of of IN cord-285335-agm4zbcx 109 4 additional additional JJ cord-285335-agm4zbcx 109 5 genomic genomic JJ cord-285335-agm4zbcx 109 6 regions region NNS cord-285335-agm4zbcx 109 7 of of IN cord-285335-agm4zbcx 109 8 these these DT cord-285335-agm4zbcx 109 9 FCoVs FCoVs NNP cord-285335-agm4zbcx 109 10 is be VBZ cord-285335-agm4zbcx 109 11 required require VBN cord-285335-agm4zbcx 109 12 to to TO cord-285335-agm4zbcx 109 13 completely completely RB cord-285335-agm4zbcx 109 14 explain explain VB cord-285335-agm4zbcx 109 15 the the DT cord-285335-agm4zbcx 109 16 increased increase VBN cord-285335-agm4zbcx 109 17 occurrence occurrence NN cord-285335-agm4zbcx 109 18 of of IN cord-285335-agm4zbcx 109 19 FIP fip NN cord-285335-agm4zbcx 109 20 in in IN cord-285335-agm4zbcx 109 21 this this DT cord-285335-agm4zbcx 109 22 population population NN cord-285335-agm4zbcx 109 23 . . . cord-285335-agm4zbcx 110 1 The the DT cord-285335-agm4zbcx 110 2 inheritance inheritance NN cord-285335-agm4zbcx 110 3 of of IN cord-285335-agm4zbcx 110 4 susceptibility susceptibility NN cord-285335-agm4zbcx 110 5 to to IN cord-285335-agm4zbcx 110 6 feline feline JJ cord-285335-agm4zbcx 110 7 infectious infectious JJ cord-285335-agm4zbcx 110 8 peritonitis peritonitis NN cord-285335-agm4zbcx 110 9 in in IN cord-285335-agm4zbcx 110 10 purebred purebred JJ cord-285335-agm4zbcx 110 11 catteries catterie NNS cord-285335-agm4zbcx 111 1 The the DT cord-285335-agm4zbcx 111 2 molecular molecular JJ cord-285335-agm4zbcx 111 3 genetics genetic NNS cord-285335-agm4zbcx 111 4 of of IN cord-285335-agm4zbcx 111 5 feline feline JJ cord-285335-agm4zbcx 111 6 coronavirus coronavirus NN cord-285335-agm4zbcx 111 7 : : : cord-285335-agm4zbcx 111 8 comparative comparative JJ cord-285335-agm4zbcx 111 9 sequence sequence NN cord-285335-agm4zbcx 111 10 analysis analysis NN cord-285335-agm4zbcx 111 11 of of IN cord-285335-agm4zbcx 111 12 the the DT cord-285335-agm4zbcx 111 13 ORF ORF NNP cord-285335-agm4zbcx 111 14 7a/7b 7a/7b CD cord-285335-agm4zbcx 111 15 transcription transcription NN cord-285335-agm4zbcx 111 16 unit unit NN cord-285335-agm4zbcx 111 17 of of IN cord-285335-agm4zbcx 111 18 different different JJ cord-285335-agm4zbcx 111 19 biotypes biotype NNS cord-285335-agm4zbcx 111 20 Perspectives perspective NNS cord-285335-agm4zbcx 111 21 on on IN cord-285335-agm4zbcx 111 22 feline feline JJ cord-285335-agm4zbcx 111 23 coronavirus coronavirus NN cord-285335-agm4zbcx 111 24 evolution evolution NN cord-285335-agm4zbcx 111 25 Veterinary Veterinary NNP cord-285335-agm4zbcx 111 26 Clinics Clinics NNPS cord-285335-agm4zbcx 111 27 of of IN cord-285335-agm4zbcx 111 28 North North NNP cord-285335-agm4zbcx 111 29 America America NNP cord-285335-agm4zbcx 111 30 : : : cord-285335-agm4zbcx 111 31 Small Small NNP cord-285335-agm4zbcx 111 32 Animal Animal NNP cord-285335-agm4zbcx 111 33 Practice Practice NNP cord-285335-agm4zbcx 111 34 Correlation correlation NN cord-285335-agm4zbcx 111 35 of of IN cord-285335-agm4zbcx 111 36 genomic genomic JJ cord-285335-agm4zbcx 111 37 detection detection NN cord-285335-agm4zbcx 111 38 of of IN cord-285335-agm4zbcx 111 39 feline feline JJ cord-285335-agm4zbcx 111 40 coronavirus coronavirus NN cord-285335-agm4zbcx 111 41 with with IN cord-285335-agm4zbcx 111 42 various various JJ cord-285335-agm4zbcx 111 43 diagnostic diagnostic JJ cord-285335-agm4zbcx 111 44 assays assay NNS cord-285335-agm4zbcx 111 45 for for IN cord-285335-agm4zbcx 111 46 feline feline JJ cord-285335-agm4zbcx 111 47 infectious infectious JJ cord-285335-agm4zbcx 111 48 peritonitis peritonitis NN cord-285335-agm4zbcx 111 49 Genetic genetic JJ cord-285335-agm4zbcx 111 50 basis basis NN cord-285335-agm4zbcx 111 51 for for IN cord-285335-agm4zbcx 111 52 species species NN cord-285335-agm4zbcx 111 53 vulnerability vulnerability NN cord-285335-agm4zbcx 111 54 in in IN cord-285335-agm4zbcx 111 55 the the DT cord-285335-agm4zbcx 111 56 cheetah cheetah NN cord-285335-agm4zbcx 111 57 Virologic Virologic NNP cord-285335-agm4zbcx 111 58 and and CC cord-285335-agm4zbcx 111 59 immunologic immunologic JJ cord-285335-agm4zbcx 111 60 aspects aspect NNS cord-285335-agm4zbcx 111 61 of of IN cord-285335-agm4zbcx 111 62 feline feline JJ cord-285335-agm4zbcx 111 63 infectious infectious JJ cord-285335-agm4zbcx 111 64 peritonitis peritonitis NN cord-285335-agm4zbcx 111 65 virus virus NN cord-285335-agm4zbcx 111 66 infection infection NN cord-285335-agm4zbcx 112 1 An an DT cord-285335-agm4zbcx 112 2 overview overview NN cord-285335-agm4zbcx 112 3 of of IN cord-285335-agm4zbcx 112 4 feline feline JJ cord-285335-agm4zbcx 112 5 enteric enteric JJ cord-285335-agm4zbcx 112 6 coronavirus coronavirus NN cord-285335-agm4zbcx 112 7 and and CC cord-285335-agm4zbcx 112 8 infectious infectious JJ cord-285335-agm4zbcx 112 9 peritonitis peritonitis NN cord-285335-agm4zbcx 112 10 virus virus NN cord-285335-agm4zbcx 112 11 infections infection NNS cord-285335-agm4zbcx 112 12 Two two CD cord-285335-agm4zbcx 112 13 related related JJ cord-285335-agm4zbcx 112 14 strains strain NNS cord-285335-agm4zbcx 112 15 of of IN cord-285335-agm4zbcx 112 16 feline feline JJ cord-285335-agm4zbcx 112 17 infectious infectious JJ cord-285335-agm4zbcx 112 18 peritonitis peritonitis NN cord-285335-agm4zbcx 112 19 virus virus NN cord-285335-agm4zbcx 112 20 isolated isolate VBN cord-285335-agm4zbcx 112 21 from from IN cord-285335-agm4zbcx 112 22 immunocompromised immunocompromised JJ cord-285335-agm4zbcx 112 23 cats cat NNS cord-285335-agm4zbcx 112 24 infected infect VBN cord-285335-agm4zbcx 112 25 with with IN cord-285335-agm4zbcx 112 26 a a DT cord-285335-agm4zbcx 112 27 feline feline JJ cord-285335-agm4zbcx 112 28 enteric enteric JJ cord-285335-agm4zbcx 112 29 coronavirus coronavirus NN cord-285335-agm4zbcx 112 30 Evaluation Evaluation NNP cord-285335-agm4zbcx 112 31 of of IN cord-285335-agm4zbcx 112 32 the the DT cord-285335-agm4zbcx 112 33 safety safety NN cord-285335-agm4zbcx 112 34 and and CC cord-285335-agm4zbcx 112 35 efficacy efficacy NN cord-285335-agm4zbcx 112 36 of of IN cord-285335-agm4zbcx 112 37 Primucell Primucell NNP cord-285335-agm4zbcx 112 38 - - HYPH cord-285335-agm4zbcx 112 39 FIP FIP NNP cord-285335-agm4zbcx 112 40 vaccine vaccine NN cord-285335-agm4zbcx 112 41 Genomic Genomic NNP cord-285335-agm4zbcx 112 42 organization organization NN cord-285335-agm4zbcx 112 43 and and CC cord-285335-agm4zbcx 112 44 expression expression NN cord-285335-agm4zbcx 112 45 of of IN cord-285335-agm4zbcx 112 46 the the DT cord-285335-agm4zbcx 112 47 3 3 CD cord-285335-agm4zbcx 112 48 0 0 CD cord-285335-agm4zbcx 112 49 -end -end : cord-285335-agm4zbcx 112 50 of of IN cord-285335-agm4zbcx 112 51 the the DT cord-285335-agm4zbcx 112 52 canine canine JJ cord-285335-agm4zbcx 112 53 and and CC cord-285335-agm4zbcx 112 54 feline feline JJ cord-285335-agm4zbcx 112 55 enteric enteric JJ cord-285335-agm4zbcx 112 56 coronaviruses coronaviruse NNS cord-285335-agm4zbcx 112 57 Feline feline JJ cord-285335-agm4zbcx 112 58 infectious infectious JJ cord-285335-agm4zbcx 112 59 peritonitis peritonitis NN cord-285335-agm4zbcx 112 60 viruses virus NNS cord-285335-agm4zbcx 112 61 arise arise VBP cord-285335-agm4zbcx 112 62 by by IN cord-285335-agm4zbcx 112 63 mutation mutation NN cord-285335-agm4zbcx 112 64 from from IN cord-285335-agm4zbcx 112 65 endemic endemic JJ cord-285335-agm4zbcx 112 66 feline feline JJ cord-285335-agm4zbcx 112 67 enteric enteric JJ cord-285335-agm4zbcx 112 68 coronaviruses coronaviruse NNS cord-285335-agm4zbcx 113 1 The the DT cord-285335-agm4zbcx 113 2 impact impact NN cord-285335-agm4zbcx 113 3 of of IN cord-285335-agm4zbcx 113 4 feline feline JJ cord-285335-agm4zbcx 113 5 infectious infectious JJ cord-285335-agm4zbcx 113 6 peritonitis peritonitis NN cord-285335-agm4zbcx 113 7 on on IN cord-285335-agm4zbcx 113 8 catteries catterie NNS cord-285335-agm4zbcx 113 9 We -PRON- PRP cord-285335-agm4zbcx 113 10 gratefully gratefully RB cord-285335-agm4zbcx 113 11 acknowledge acknowledge VBP cord-285335-agm4zbcx 113 12 and and CC cord-285335-agm4zbcx 113 13 thank thank VBP cord-285335-agm4zbcx 113 14 Morris Morris NNP cord-285335-agm4zbcx 113 15 animal animal NN cord-285335-agm4zbcx 113 16 Foundation Foundation NNP cord-285335-agm4zbcx 113 17 for for IN cord-285335-agm4zbcx 113 18 its -PRON- PRP$ cord-285335-agm4zbcx 113 19 financial financial JJ cord-285335-agm4zbcx 113 20 , , , cord-285335-agm4zbcx 113 21 technical technical JJ cord-285335-agm4zbcx 113 22 , , , cord-285335-agm4zbcx 113 23 and and CC cord-285335-agm4zbcx 113 24 administrative administrative JJ cord-285335-agm4zbcx 113 25 assistance assistance NN cord-285335-agm4zbcx 113 26 in in IN cord-285335-agm4zbcx 113 27 funding fund VBG cord-285335-agm4zbcx 113 28 and and CC cord-285335-agm4zbcx 113 29 managing manage VBG cord-285335-agm4zbcx 113 30 the the DT cord-285335-agm4zbcx 113 31 research research NN cord-285335-agm4zbcx 113 32 through through IN cord-285335-agm4zbcx 113 33 which which WDT cord-285335-agm4zbcx 113 34 this this DT cord-285335-agm4zbcx 113 35 information information NN cord-285335-agm4zbcx 113 36 was be VBD cord-285335-agm4zbcx 113 37 discovered discover VBN cord-285335-agm4zbcx 113 38 . . . cord-285335-agm4zbcx 114 1 We -PRON- PRP cord-285335-agm4zbcx 114 2 would would MD cord-285335-agm4zbcx 114 3 also also RB cord-285335-agm4zbcx 114 4 like like VB cord-285335-agm4zbcx 114 5 to to TO cord-285335-agm4zbcx 114 6 thank thank VB cord-285335-agm4zbcx 114 7 Dr. Dr. NNP cord-285335-agm4zbcx 114 8 Michael Michael NNP cord-285335-agm4zbcx 114 9 Kiningham Kiningham NNP cord-285335-agm4zbcx 114 10 for for IN cord-285335-agm4zbcx 114 11 his -PRON- PRP$ cord-285335-agm4zbcx 114 12 assistance assistance NN cord-285335-agm4zbcx 114 13 in in IN cord-285335-agm4zbcx 114 14 this this DT cord-285335-agm4zbcx 114 15 investigation investigation NN cord-285335-agm4zbcx 114 16 . . .