id	sid	tid	token	lemma	pos
cord-291950-9gtsqyfj	1	1	key	key	JJ
cord-291950-9gtsqyfj	1	2	:	:	:
cord-291950-9gtsqyfj	1	3	cord-291950	cord-291950	NNP
cord-291950-9gtsqyfj	1	4	-	-	HYPH
cord-291950-9gtsqyfj	1	5	9gtsqyfj	9gtsqyfj	CD
cord-291950-9gtsqyfj	1	6	authors	author	NNS
cord-291950-9gtsqyfj	1	7	:	:	:
cord-291950-9gtsqyfj	1	8	Rawlings	Rawlings	NNP
cord-291950-9gtsqyfj	1	9	,	,	,
cord-291950-9gtsqyfj	1	10	Neil	Neil	NNP
cord-291950-9gtsqyfj	1	11	D.	D.	NNP
cord-291950-9gtsqyfj	1	12	;	;	:
cord-291950-9gtsqyfj	1	13	Barrett	Barrett	NNP
cord-291950-9gtsqyfj	1	14	,	,	,
cord-291950-9gtsqyfj	1	15	Alan	Alan	NNP
cord-291950-9gtsqyfj	1	16	J.	J.	NNP
cord-291950-9gtsqyfj	1	17	title	title	NN
cord-291950-9gtsqyfj	1	18	:	:	:
cord-291950-9gtsqyfj	1	19	Introduction	introduction	NN
cord-291950-9gtsqyfj	1	20	:	:	:
cord-291950-9gtsqyfj	2	1	The	the	DT
cord-291950-9gtsqyfj	2	2	Clans	Clans	NNPS
cord-291950-9gtsqyfj	2	3	and	and	CC
cord-291950-9gtsqyfj	2	4	Families	family	NNS
cord-291950-9gtsqyfj	2	5	of	of	IN
cord-291950-9gtsqyfj	2	6	Cysteine	Cysteine	NNP
cord-291950-9gtsqyfj	2	7	Peptidases	Peptidases	NNP
cord-291950-9gtsqyfj	2	8	date	date	NN
cord-291950-9gtsqyfj	2	9	:	:	:
cord-291950-9gtsqyfj	2	10	2012	2012	CD
cord-291950-9gtsqyfj	2	11	-	-	SYM
cord-291950-9gtsqyfj	2	12	11	11	CD
cord-291950-9gtsqyfj	2	13	-	-	HYPH
cord-291950-9gtsqyfj	2	14	09	09	CD
cord-291950-9gtsqyfj	2	15	journal	journal	NN
cord-291950-9gtsqyfj	2	16	:	:	:
cord-291950-9gtsqyfj	3	1	Handbook	Handbook	NNP
cord-291950-9gtsqyfj	3	2	of	of	IN
cord-291950-9gtsqyfj	3	3	Proteolytic	Proteolytic	NNP
cord-291950-9gtsqyfj	3	4	Enzymes	enzyme	NNS
cord-291950-9gtsqyfj	4	1	DOI	DOI	NNP
cord-291950-9gtsqyfj	4	2	:	:	:
cord-291950-9gtsqyfj	5	1	10.1016	10.1016	CD
cord-291950-9gtsqyfj	5	2	/	/	SYM
cord-291950-9gtsqyfj	5	3	b978	b978	NN
cord-291950-9gtsqyfj	5	4	-	-	HYPH
cord-291950-9gtsqyfj	5	5	0	0	CD
cord-291950-9gtsqyfj	5	6	-	-	HYPH
cord-291950-9gtsqyfj	5	7	12	12	CD
cord-291950-9gtsqyfj	5	8	-	-	HYPH
cord-291950-9gtsqyfj	5	9	382219	382219	CD
cord-291950-9gtsqyfj	5	10	-	-	HYPH
cord-291950-9gtsqyfj	5	11	2.00404-x	2.00404-x	CD
cord-291950-9gtsqyfj	5	12	sha	sha	NNP
cord-291950-9gtsqyfj	5	13	:	:	:
cord-291950-9gtsqyfj	6	1	1f095b254f7775c63b8df3e68e7fddf12eae4b46	1f095b254f7775c63b8df3e68e7fddf12eae4b46	LS
cord-291950-9gtsqyfj	6	2	doc_id	doc_id	CD
cord-291950-9gtsqyfj	6	3	:	:	:
cord-291950-9gtsqyfj	7	1	291950	291950	CD
cord-291950-9gtsqyfj	7	2	cord_uid	cord_uid	NNS
cord-291950-9gtsqyfj	7	3	:	:	:
cord-291950-9gtsqyfj	8	1	9gtsqyfj	9gtsqyfj	LS
cord-291950-9gtsqyfj	9	1	The	the	DT
cord-291950-9gtsqyfj	9	2	third	third	JJ
cord-291950-9gtsqyfj	9	3	edition	edition	NN
cord-291950-9gtsqyfj	9	4	of	of	IN
cord-291950-9gtsqyfj	9	5	the	the	DT
cord-291950-9gtsqyfj	9	6	Handbook	Handbook	NNP
cord-291950-9gtsqyfj	9	7	of	of	IN
cord-291950-9gtsqyfj	9	8	Proteolytic	Proteolytic	NNP
cord-291950-9gtsqyfj	9	9	Enzymes	enzyme	NNS
cord-291950-9gtsqyfj	9	10	aims	aim	VBZ
cord-291950-9gtsqyfj	9	11	to	to	TO
cord-291950-9gtsqyfj	9	12	be	be	VB
cord-291950-9gtsqyfj	9	13	a	a	DT
cord-291950-9gtsqyfj	9	14	comprehensive	comprehensive	JJ
cord-291950-9gtsqyfj	9	15	reference	reference	NN
cord-291950-9gtsqyfj	9	16	work	work	NN
cord-291950-9gtsqyfj	9	17	for	for	IN
cord-291950-9gtsqyfj	9	18	the	the	DT
cord-291950-9gtsqyfj	9	19	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	9	20	that	that	WDT
cord-291950-9gtsqyfj	9	21	cleave	cleave	VBP
cord-291950-9gtsqyfj	9	22	proteins	protein	NNS
cord-291950-9gtsqyfj	9	23	and	and	CC
cord-291950-9gtsqyfj	9	24	peptides	peptide	NNS
cord-291950-9gtsqyfj	9	25	,	,	,
cord-291950-9gtsqyfj	9	26	and	and	CC
cord-291950-9gtsqyfj	9	27	contains	contain	VBZ
cord-291950-9gtsqyfj	9	28	over	over	IN
cord-291950-9gtsqyfj	9	29	800	800	CD
cord-291950-9gtsqyfj	9	30	chapters	chapter	NNS
cord-291950-9gtsqyfj	9	31	.	.	.
cord-291950-9gtsqyfj	10	1	Each	each	DT
cord-291950-9gtsqyfj	10	2	chapter	chapter	NN
cord-291950-9gtsqyfj	10	3	is	be	VBZ
cord-291950-9gtsqyfj	10	4	organized	organize	VBN
cord-291950-9gtsqyfj	10	5	into	into	IN
cord-291950-9gtsqyfj	10	6	sections	section	NNS
cord-291950-9gtsqyfj	10	7	describing	describe	VBG
cord-291950-9gtsqyfj	10	8	the	the	DT
cord-291950-9gtsqyfj	10	9	name	name	NN
cord-291950-9gtsqyfj	10	10	and	and	CC
cord-291950-9gtsqyfj	10	11	history	history	NN
cord-291950-9gtsqyfj	10	12	,	,	,
cord-291950-9gtsqyfj	10	13	activity	activity	NN
cord-291950-9gtsqyfj	10	14	and	and	CC
cord-291950-9gtsqyfj	10	15	specificity	specificity	NN
cord-291950-9gtsqyfj	10	16	,	,	,
cord-291950-9gtsqyfj	10	17	structural	structural	JJ
cord-291950-9gtsqyfj	10	18	chemistry	chemistry	NN
cord-291950-9gtsqyfj	10	19	,	,	,
cord-291950-9gtsqyfj	10	20	preparation	preparation	NN
cord-291950-9gtsqyfj	10	21	,	,	,
cord-291950-9gtsqyfj	10	22	biological	biological	JJ
cord-291950-9gtsqyfj	10	23	aspects	aspect	NNS
cord-291950-9gtsqyfj	10	24	,	,	,
cord-291950-9gtsqyfj	10	25	and	and	CC
cord-291950-9gtsqyfj	10	26	distinguishing	distinguishing	JJ
cord-291950-9gtsqyfj	10	27	features	feature	NNS
cord-291950-9gtsqyfj	10	28	for	for	IN
cord-291950-9gtsqyfj	10	29	a	a	DT
cord-291950-9gtsqyfj	10	30	specific	specific	JJ
cord-291950-9gtsqyfj	10	31	peptidase	peptidase	NN
cord-291950-9gtsqyfj	10	32	.	.	.
cord-291950-9gtsqyfj	11	1	The	the	DT
cord-291950-9gtsqyfj	11	2	subject	subject	NN
cord-291950-9gtsqyfj	11	3	of	of	IN
cord-291950-9gtsqyfj	11	4	Chapter	chapter	NN
cord-291950-9gtsqyfj	11	5	404	404	CD
cord-291950-9gtsqyfj	11	6	is	be	VBZ
cord-291950-9gtsqyfj	11	7	Clans	Clans	NNPS
cord-291950-9gtsqyfj	11	8	and	and	CC
cord-291950-9gtsqyfj	11	9	Families	family	NNS
cord-291950-9gtsqyfj	11	10	of	of	IN
cord-291950-9gtsqyfj	11	11	Cysteine	Cysteine	NNP
cord-291950-9gtsqyfj	11	12	Peptidases	Peptidases	NNPS
cord-291950-9gtsqyfj	11	13	.	.	.
cord-291950-9gtsqyfj	12	1	Peptidases	peptidase	NNS
cord-291950-9gtsqyfj	12	2	in	in	IN
cord-291950-9gtsqyfj	12	3	which	which	WDT
cord-291950-9gtsqyfj	12	4	the	the	DT
cord-291950-9gtsqyfj	12	5	nucleophile	nucleophile	NN
cord-291950-9gtsqyfj	12	6	that	that	WDT
cord-291950-9gtsqyfj	12	7	attacks	attack	VBZ
cord-291950-9gtsqyfj	12	8	the	the	DT
cord-291950-9gtsqyfj	12	9	scissile	scissile	NNP
cord-291950-9gtsqyfj	12	10	peptide	peptide	NNP
cord-291950-9gtsqyfj	12	11	bond	bond	NN
cord-291950-9gtsqyfj	12	12	is	be	VBZ
cord-291950-9gtsqyfj	12	13	the	the	DT
cord-291950-9gtsqyfj	12	14	sulfhydryl	sulfhydryl	NN
cord-291950-9gtsqyfj	12	15	group	group	NN
cord-291950-9gtsqyfj	12	16	of	of	IN
cord-291950-9gtsqyfj	12	17	a	a	DT
cord-291950-9gtsqyfj	12	18	cysteine	cysteine	NN
cord-291950-9gtsqyfj	12	19	residue	residue	NN
cord-291950-9gtsqyfj	12	20	are	be	VBP
cord-291950-9gtsqyfj	12	21	known	know	VBN
cord-291950-9gtsqyfj	12	22	as	as	IN
cord-291950-9gtsqyfj	12	23	cysteine	cysteine	NN
cord-291950-9gtsqyfj	12	24	-	-	HYPH
cord-291950-9gtsqyfj	12	25	type	type	NN
cord-291950-9gtsqyfj	12	26	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	12	27	.	.	.
cord-291950-9gtsqyfj	13	1	The	the	DT
cord-291950-9gtsqyfj	13	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	13	3	mechanism	mechanism	NN
cord-291950-9gtsqyfj	13	4	is	be	VBZ
cord-291950-9gtsqyfj	13	5	similar	similar	JJ
cord-291950-9gtsqyfj	13	6	to	to	IN
cord-291950-9gtsqyfj	13	7	that	that	DT
cord-291950-9gtsqyfj	13	8	of	of	IN
cord-291950-9gtsqyfj	13	9	the	the	DT
cord-291950-9gtsqyfj	13	10	serine	serine	NN
cord-291950-9gtsqyfj	13	11	-	-	HYPH
cord-291950-9gtsqyfj	13	12	type	type	NN
cord-291950-9gtsqyfj	13	13	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	13	14	in	in	IN
cord-291950-9gtsqyfj	13	15	that	that	IN
cord-291950-9gtsqyfj	13	16	a	a	DT
cord-291950-9gtsqyfj	13	17	nucleophile	nucleophile	NN
cord-291950-9gtsqyfj	13	18	and	and	CC
cord-291950-9gtsqyfj	13	19	a	a	DT
cord-291950-9gtsqyfj	13	20	proton	proton	NN
cord-291950-9gtsqyfj	13	21	donor	donor	NN
cord-291950-9gtsqyfj	13	22	/	/	SYM
cord-291950-9gtsqyfj	13	23	general	general	JJ
cord-291950-9gtsqyfj	13	24	base	base	NN
cord-291950-9gtsqyfj	13	25	are	be	VBP
cord-291950-9gtsqyfj	13	26	required	require	VBN
cord-291950-9gtsqyfj	13	27	,	,	,
cord-291950-9gtsqyfj	13	28	and	and	CC
cord-291950-9gtsqyfj	13	29	the	the	DT
cord-291950-9gtsqyfj	13	30	proton	proton	NN
cord-291950-9gtsqyfj	13	31	donor	donor	NN
cord-291950-9gtsqyfj	13	32	in	in	IN
cord-291950-9gtsqyfj	13	33	all	all	DT
cord-291950-9gtsqyfj	13	34	cysteine	cysteine	NN
cord-291950-9gtsqyfj	13	35	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	13	36	in	in	IN
cord-291950-9gtsqyfj	13	37	which	which	WDT
cord-291950-9gtsqyfj	13	38	it	-PRON-	PRP
cord-291950-9gtsqyfj	13	39	has	have	VBZ
cord-291950-9gtsqyfj	13	40	been	be	VBN
cord-291950-9gtsqyfj	13	41	identified	identify	VBN
cord-291950-9gtsqyfj	13	42	is	be	VBZ
cord-291950-9gtsqyfj	13	43	a	a	DT
cord-291950-9gtsqyfj	13	44	histidine	histidine	NN
cord-291950-9gtsqyfj	13	45	residue	residue	NN
cord-291950-9gtsqyfj	13	46	,	,	,
cord-291950-9gtsqyfj	13	47	as	as	IN
cord-291950-9gtsqyfj	13	48	in	in	IN
cord-291950-9gtsqyfj	13	49	the	the	DT
cord-291950-9gtsqyfj	13	50	majority	majority	NN
cord-291950-9gtsqyfj	13	51	of	of	IN
cord-291950-9gtsqyfj	13	52	serine	serine	NN
cord-291950-9gtsqyfj	13	53	-	-	HYPH
cord-291950-9gtsqyfj	13	54	type	type	NN
cord-291950-9gtsqyfj	13	55	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	13	56	.	.	.
cord-291950-9gtsqyfj	14	1	In	in	IN
cord-291950-9gtsqyfj	14	2	some	some	DT
cord-291950-9gtsqyfj	14	3	families	family	NNS
cord-291950-9gtsqyfj	14	4	only	only	RB
cord-291950-9gtsqyfj	14	5	the	the	DT
cord-291950-9gtsqyfj	14	6	dyad	dyad	NN
cord-291950-9gtsqyfj	14	7	of	of	IN
cord-291950-9gtsqyfj	14	8	Cys	Cys	NNP
cord-291950-9gtsqyfj	14	9	and	and	CC
cord-291950-9gtsqyfj	14	10	His	-PRON-	PRP$
cord-291950-9gtsqyfj	14	11	seems	seem	VBZ
cord-291950-9gtsqyfj	14	12	to	to	TO
cord-291950-9gtsqyfj	14	13	be	be	VB
cord-291950-9gtsqyfj	14	14	essential	essential	JJ
cord-291950-9gtsqyfj	14	15	for	for	IN
cord-291950-9gtsqyfj	14	16	catalysis	catalysis	NN
cord-291950-9gtsqyfj	14	17	,	,	,
cord-291950-9gtsqyfj	14	18	whereas	whereas	IN
cord-291950-9gtsqyfj	14	19	in	in	IN
cord-291950-9gtsqyfj	14	20	others	other	NNS
cord-291950-9gtsqyfj	14	21	there	there	EX
cord-291950-9gtsqyfj	14	22	is	be	VBZ
cord-291950-9gtsqyfj	14	23	evidence	evidence	NN
cord-291950-9gtsqyfj	14	24	that	that	IN
cord-291950-9gtsqyfj	14	25	a	a	DT
cord-291950-9gtsqyfj	14	26	third	third	JJ
cord-291950-9gtsqyfj	14	27	residue	residue	NN
cord-291950-9gtsqyfj	14	28	is	be	VBZ
cord-291950-9gtsqyfj	14	29	required	require	VBN
cord-291950-9gtsqyfj	14	30	to	to	TO
cord-291950-9gtsqyfj	14	31	orientate	orientate	VB
cord-291950-9gtsqyfj	14	32	the	the	DT
cord-291950-9gtsqyfj	14	33	imidazolium	imidazolium	NN
cord-291950-9gtsqyfj	14	34	ring	ring	NN
cord-291950-9gtsqyfj	14	35	of	of	IN
cord-291950-9gtsqyfj	14	36	the	the	DT
cord-291950-9gtsqyfj	14	37	His	His	NNP
cord-291950-9gtsqyfj	14	38	(	(	-LRB-
cord-291950-9gtsqyfj	14	39	a	a	DT
cord-291950-9gtsqyfj	14	40	role	role	NN
cord-291950-9gtsqyfj	14	41	analogous	analogous	JJ
cord-291950-9gtsqyfj	14	42	to	to	IN
cord-291950-9gtsqyfj	14	43	that	that	DT
cord-291950-9gtsqyfj	14	44	of	of	IN
cord-291950-9gtsqyfj	14	45	the	the	DT
cord-291950-9gtsqyfj	14	46	essential	essential	JJ
cord-291950-9gtsqyfj	14	47	aspartate	aspartate	NN
cord-291950-9gtsqyfj	14	48	in	in	IN
cord-291950-9gtsqyfj	14	49	some	some	DT
cord-291950-9gtsqyfj	14	50	serine	serine	NN
cord-291950-9gtsqyfj	14	51	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	14	52	)	)	-RRB-
cord-291950-9gtsqyfj	14	53	.	.	.
cord-291950-9gtsqyfj	15	1	The	the	DT
cord-291950-9gtsqyfj	15	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	15	3	mechanisms	mechanism	NNS
cord-291950-9gtsqyfj	15	4	of	of	IN
cord-291950-9gtsqyfj	15	5	cysteine	cysteine	NN
cord-291950-9gtsqyfj	15	6	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	15	7	are	be	VBP
cord-291950-9gtsqyfj	15	8	described	describe	VBN
cord-291950-9gtsqyfj	15	9	fully	fully	RB
cord-291950-9gtsqyfj	15	10	in	in	IN
cord-291950-9gtsqyfj	15	11	Chapter	chapter	NN
cord-291950-9gtsqyfj	15	12	405	405	CD
cord-291950-9gtsqyfj	15	13	.	.	.
cord-291950-9gtsqyfj	16	1	The	the	DT
cord-291950-9gtsqyfj	16	2	clans	clan	NNS
cord-291950-9gtsqyfj	16	3	and	and	CC
cord-291950-9gtsqyfj	16	4	families	family	NNS
cord-291950-9gtsqyfj	16	5	of	of	IN
cord-291950-9gtsqyfj	16	6	cysteine	cysteine	NN
cord-291950-9gtsqyfj	16	7	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	16	8	are	be	VBP
cord-291950-9gtsqyfj	16	9	listed	list	VBN
cord-291950-9gtsqyfj	16	10	in	in	IN
cord-291950-9gtsqyfj	16	11	Table	Table	NNP
cord-291950-9gtsqyfj	16	12	404	404	CD
cord-291950-9gtsqyfj	16	13	.1	.1	.
cord-291950-9gtsqyfj	16	14	.	.	.
cord-291950-9gtsqyfj	17	1	The	the	DT
cord-291950-9gtsqyfj	17	2	first	first	JJ
cord-291950-9gtsqyfj	17	3	clearly	clearly	RB
cord-291950-9gtsqyfj	17	4	recognized	recognize	VBN
cord-291950-9gtsqyfj	17	5	cysteine	cysteine	NN
cord-291950-9gtsqyfj	17	6	peptidase	peptidase	NN
cord-291950-9gtsqyfj	17	7	was	be	VBD
cord-291950-9gtsqyfj	17	8	papain	papain	NN
cord-291950-9gtsqyfj	17	9	(	(	-LRB-
cord-291950-9gtsqyfj	17	10	Chapter	chapter	NN
cord-291950-9gtsqyfj	17	11	418	418	CD
cord-291950-9gtsqyfj	17	12	)	)	-RRB-
cord-291950-9gtsqyfj	17	13	,	,	,
cord-291950-9gtsqyfj	17	14	and	and	CC
cord-291950-9gtsqyfj	17	15	this	this	DT
cord-291950-9gtsqyfj	17	16	forms	form	VBZ
cord-291950-9gtsqyfj	17	17	the	the	DT
cord-291950-9gtsqyfj	17	18	foundation	foundation	NN
cord-291950-9gtsqyfj	17	19	of	of	IN
cord-291950-9gtsqyfj	17	20	clan	clan	NNP
cord-291950-9gtsqyfj	17	21	CA	CA	NNP
cord-291950-9gtsqyfj	17	22	.	.	.
cord-291950-9gtsqyfj	18	1	The	the	DT
cord-291950-9gtsqyfj	18	2	crystal	crystal	NN
cord-291950-9gtsqyfj	18	3	structure	structure	NN
cord-291950-9gtsqyfj	18	4	(	(	-LRB-
cord-291950-9gtsqyfj	18	5	Figure	figure	NN
cord-291950-9gtsqyfj	18	6	404.1	404.1	CD
cord-291950-9gtsqyfj	18	7	)	)	-RRB-
cord-291950-9gtsqyfj	18	8	shows	show	VBZ
cord-291950-9gtsqyfj	18	9	two	two	CD
cord-291950-9gtsqyfj	18	10	structural	structural	JJ
cord-291950-9gtsqyfj	18	11	domains	domain	NNS
cord-291950-9gtsqyfj	18	12	separated	separate	VBN
cord-291950-9gtsqyfj	18	13	by	by	IN
cord-291950-9gtsqyfj	18	14	the	the	DT
cord-291950-9gtsqyfj	18	15	active	active	JJ
cord-291950-9gtsqyfj	18	16	site	site	NN
cord-291950-9gtsqyfj	18	17	cleft	cleft	NN
cord-291950-9gtsqyfj	18	18	.	.	.
cord-291950-9gtsqyfj	19	1	The	the	DT
cord-291950-9gtsqyfj	19	2	N	n	CD
cord-291950-9gtsqyfj	19	3	-	-	HYPH
cord-291950-9gtsqyfj	19	4	terminal	terminal	NN
cord-291950-9gtsqyfj	19	5	domain	domain	NN
cord-291950-9gtsqyfj	19	6	consists	consist	VBZ
cord-291950-9gtsqyfj	19	7	largely	largely	RB
cord-291950-9gtsqyfj	19	8	of	of	IN
cord-291950-9gtsqyfj	19	9	a	a	DT
cord-291950-9gtsqyfj	19	10	bundle	bundle	NN
cord-291950-9gtsqyfj	19	11	of	of	IN
cord-291950-9gtsqyfj	19	12	α	α	NN
cord-291950-9gtsqyfj	19	13	-	-	HYPH
cord-291950-9gtsqyfj	19	14	helices	helix	NNS
cord-291950-9gtsqyfj	19	15	whereas	whereas	IN
cord-291950-9gtsqyfj	19	16	the	the	DT
cord-291950-9gtsqyfj	19	17	C	c	NN
cord-291950-9gtsqyfj	19	18	-	-	HYPH
cord-291950-9gtsqyfj	19	19	terminal	terminal	NN
cord-291950-9gtsqyfj	19	20	domain	domain	NN
cord-291950-9gtsqyfj	19	21	contains	contain	VBZ
cord-291950-9gtsqyfj	19	22	a	a	DT
cord-291950-9gtsqyfj	19	23	β	β	NN
cord-291950-9gtsqyfj	19	24	-	-	HYPH
cord-291950-9gtsqyfj	19	25	barrel	barrel	NN
cord-291950-9gtsqyfj	19	26	.	.	.
cord-291950-9gtsqyfj	20	1	A	a	DT
cord-291950-9gtsqyfj	20	2	long	long	JJ
cord-291950-9gtsqyfj	20	3	helix	helix	NN
cord-291950-9gtsqyfj	20	4	runs	run	NNS
cord-291950-9gtsqyfj	20	5	through	through	IN
cord-291950-9gtsqyfj	20	6	the	the	DT
cord-291950-9gtsqyfj	20	7	middle	middle	NN
cord-291950-9gtsqyfj	20	8	of	of	IN
cord-291950-9gtsqyfj	20	9	the	the	DT
cord-291950-9gtsqyfj	20	10	molecule	molecule	NN
cord-291950-9gtsqyfj	20	11	,	,	,
cord-291950-9gtsqyfj	20	12	and	and	CC
cord-291950-9gtsqyfj	20	13	the	the	DT
cord-291950-9gtsqyfj	20	14	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	20	15	cysteine	cysteine	NN
cord-291950-9gtsqyfj	20	16	is	be	VBZ
cord-291950-9gtsqyfj	20	17	at	at	IN
cord-291950-9gtsqyfj	20	18	the	the	DT
cord-291950-9gtsqyfj	20	19	start	start	NN
cord-291950-9gtsqyfj	20	20	of	of	IN
cord-291950-9gtsqyfj	20	21	this	this	DT
cord-291950-9gtsqyfj	20	22	.	.	.
cord-291950-9gtsqyfj	21	1	Clan	Clan	NNP
cord-291950-9gtsqyfj	21	2	CA	CA	NNP
cord-291950-9gtsqyfj	21	3	contains	contain	VBZ
cord-291950-9gtsqyfj	21	4	over	over	IN
cord-291950-9gtsqyfj	21	5	20	20	CD
cord-291950-9gtsqyfj	21	6	families	family	NNS
cord-291950-9gtsqyfj	21	7	(	(	-LRB-
cord-291950-9gtsqyfj	21	8	see	see	VB
cord-291950-9gtsqyfj	21	9	Table	table	NN
cord-291950-9gtsqyfj	21	10	404	404	CD
cord-291950-9gtsqyfj	21	11	.1	.1	CD
cord-291950-9gtsqyfj	21	12	)	)	-RRB-
cord-291950-9gtsqyfj	21	13	.	.	.
cord-291950-9gtsqyfj	22	1	Almost	almost	RB
cord-291950-9gtsqyfj	22	2	all	all	DT
cord-291950-9gtsqyfj	22	3	of	of	IN
cord-291950-9gtsqyfj	22	4	these	these	DT
cord-291950-9gtsqyfj	22	5	have	have	VBP
cord-291950-9gtsqyfj	22	6	been	be	VBN
cord-291950-9gtsqyfj	22	7	brought	bring	VBN
cord-291950-9gtsqyfj	22	8	into	into	IN
cord-291950-9gtsqyfj	22	9	the	the	DT
cord-291950-9gtsqyfj	22	10	clan	clan	NN
cord-291950-9gtsqyfj	22	11	on	on	IN
cord-291950-9gtsqyfj	22	12	the	the	DT
cord-291950-9gtsqyfj	22	13	basis	basis	NN
cord-291950-9gtsqyfj	22	14	of	of	IN
cord-291950-9gtsqyfj	22	15	structures	structure	NNS
cord-291950-9gtsqyfj	22	16	that	that	WDT
cord-291950-9gtsqyfj	22	17	are	be	VBP
cord-291950-9gtsqyfj	22	18	known	know	VBN
cord-291950-9gtsqyfj	22	19	from	from	IN
cord-291950-9gtsqyfj	22	20	crystallographic	crystallographic	JJ
cord-291950-9gtsqyfj	22	21	data	datum	NNS
cord-291950-9gtsqyfj	22	22	to	to	TO
cord-291950-9gtsqyfj	22	23	be	be	VB
cord-291950-9gtsqyfj	22	24	similar	similar	JJ
cord-291950-9gtsqyfj	22	25	.	.	.
cord-291950-9gtsqyfj	23	1	The	the	DT
cord-291950-9gtsqyfj	23	2	other	other	JJ
cord-291950-9gtsqyfj	23	3	families	family	NNS
cord-291950-9gtsqyfj	23	4	are	be	VBP
cord-291950-9gtsqyfj	23	5	assigned	assign	VBN
cord-291950-9gtsqyfj	23	6	to	to	TO
cord-291950-9gtsqyfj	23	7	clan	clan	VB
cord-291950-9gtsqyfj	23	8	CA	CA	NNP
cord-291950-9gtsqyfj	23	9	because	because	IN
cord-291950-9gtsqyfj	23	10	they	-PRON-	PRP
cord-291950-9gtsqyfj	23	11	contain	contain	VBP
cord-291950-9gtsqyfj	23	12	similar	similar	JJ
cord-291950-9gtsqyfj	23	13	sequence	sequence	NN
cord-291950-9gtsqyfj	23	14	motifs	motif	NNS
cord-291950-9gtsqyfj	23	15	around	around	IN
cord-291950-9gtsqyfj	23	16	the	the	DT
cord-291950-9gtsqyfj	23	17	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	23	18	residues	residue	NNS
cord-291950-9gtsqyfj	23	19	(	(	-LRB-
cord-291950-9gtsqyfj	23	20	Figures	figure	NNS
cord-291950-9gtsqyfj	23	21	404.2À404.7	404.2à404.7	CD
cord-291950-9gtsqyfj	23	22	)	)	-RRB-
cord-291950-9gtsqyfj	23	23	.	.	.
cord-291950-9gtsqyfj	24	1	Besides	besides	IN
cord-291950-9gtsqyfj	24	2	Cys158	cys158	CD
cord-291950-9gtsqyfj	24	3	and	and	CC
cord-291950-9gtsqyfj	24	4	His292	his292	DT
cord-291950-9gtsqyfj	24	5	of	of	IN
cord-291950-9gtsqyfj	24	6	the	the	DT
cord-291950-9gtsqyfj	24	7	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	24	8	dyad	dyad	NN
cord-291950-9gtsqyfj	24	9	,	,	,
cord-291950-9gtsqyfj	24	10	two	two	CD
cord-291950-9gtsqyfj	24	11	other	other	JJ
cord-291950-9gtsqyfj	24	12	residues	residue	NNS
cord-291950-9gtsqyfj	24	13	are	be	VBP
cord-291950-9gtsqyfj	24	14	important	important	JJ
cord-291950-9gtsqyfj	24	15	for	for	IN
cord-291950-9gtsqyfj	24	16	catalysis	catalysis	NN
cord-291950-9gtsqyfj	24	17	in	in	IN
cord-291950-9gtsqyfj	24	18	papain	papain	NN
cord-291950-9gtsqyfj	24	19	and	and	CC
cord-291950-9gtsqyfj	24	20	its	-PRON-	PRP$
cord-291950-9gtsqyfj	24	21	relatives	relative	NNS
cord-291950-9gtsqyfj	24	22	(	(	-LRB-
cord-291950-9gtsqyfj	24	23	numbering	number	VBG
cord-291950-9gtsqyfj	24	24	as	as	IN
cord-291950-9gtsqyfj	24	25	in	in	IN
cord-291950-9gtsqyfj	24	26	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	24	27	database	database	NN
cord-291950-9gtsqyfj	24	28	)	)	-RRB-
cord-291950-9gtsqyfj	24	29	.	.	.
cord-291950-9gtsqyfj	25	1	These	these	DT
cord-291950-9gtsqyfj	25	2	are	be	VBP
cord-291950-9gtsqyfj	25	3	a	a	DT
cord-291950-9gtsqyfj	25	4	Gln152	gln152	NN
cord-291950-9gtsqyfj	25	5	that	that	WDT
cord-291950-9gtsqyfj	25	6	helps	help	VBZ
cord-291950-9gtsqyfj	25	7	in	in	IN
cord-291950-9gtsqyfj	25	8	the	the	DT
cord-291950-9gtsqyfj	25	9	formation	formation	NN
cord-291950-9gtsqyfj	25	10	of	of	IN
cord-291950-9gtsqyfj	25	11	the	the	DT
cord-291950-9gtsqyfj	25	12	'	'	``
cord-291950-9gtsqyfj	25	13	oxyanion	oxyanion	NN
cord-291950-9gtsqyfj	25	14	hole	hole	NN
cord-291950-9gtsqyfj	25	15	'	'	''
cord-291950-9gtsqyfj	25	16	,	,	,
cord-291950-9gtsqyfj	25	17	an	an	DT
cord-291950-9gtsqyfj	25	18	electrophilic	electrophilic	JJ
cord-291950-9gtsqyfj	25	19	center	center	NN
cord-291950-9gtsqyfj	25	20	that	that	WDT
cord-291950-9gtsqyfj	25	21	stabilizes	stabilize	VBZ
cord-291950-9gtsqyfj	25	22	the	the	DT
cord-291950-9gtsqyfj	25	23	tetrahedral	tetrahedral	JJ
cord-291950-9gtsqyfj	25	24	intermediate	intermediate	NN
cord-291950-9gtsqyfj	25	25	,	,	,
cord-291950-9gtsqyfj	25	26	and	and	CC
cord-291950-9gtsqyfj	25	27	Asn308	Asn308	.
cord-291950-9gtsqyfj	26	1	(	(	-LRB-
cord-291950-9gtsqyfj	26	2	sometimes	sometimes	RB
cord-291950-9gtsqyfj	26	3	Asp	Asp	NNP
cord-291950-9gtsqyfj	26	4	in	in	IN
cord-291950-9gtsqyfj	26	5	families	family	NNS
cord-291950-9gtsqyfj	26	6	C12	C12	NNP
cord-291950-9gtsqyfj	26	7	,	,	,
cord-291950-9gtsqyfj	26	8	C28	C28	NNP
cord-291950-9gtsqyfj	26	9	and	and	CC
cord-291950-9gtsqyfj	26	10	C39	C39	NNP
cord-291950-9gtsqyfj	26	11	)	)	-RRB-
cord-291950-9gtsqyfj	26	12	,	,	,
cord-291950-9gtsqyfj	26	13	which	which	WDT
cord-291950-9gtsqyfj	26	14	is	be	VBZ
cord-291950-9gtsqyfj	26	15	thought	think	VBN
cord-291950-9gtsqyfj	26	16	to	to	TO
cord-291950-9gtsqyfj	26	17	orientate	orientate	VB
cord-291950-9gtsqyfj	26	18	the	the	DT
cord-291950-9gtsqyfj	26	19	imidazolium	imidazolium	NN
cord-291950-9gtsqyfj	26	20	ring	ring	NN
cord-291950-9gtsqyfj	26	21	of	of	IN
cord-291950-9gtsqyfj	26	22	the	the	DT
cord-291950-9gtsqyfj	26	23	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	26	24	His	His	NNP
cord-291950-9gtsqyfj	26	25	(	(	-LRB-
cord-291950-9gtsqyfj	26	26	Chapter	chapter	NN
cord-291950-9gtsqyfj	26	27	405	405	CD
cord-291950-9gtsqyfj	26	28	)	)	-RRB-
cord-291950-9gtsqyfj	26	29	.	.	.
cord-291950-9gtsqyfj	27	1	The	the	DT
cord-291950-9gtsqyfj	27	2	order	order	NN
cord-291950-9gtsqyfj	27	3	of	of	IN
cord-291950-9gtsqyfj	27	4	these	these	DT
cord-291950-9gtsqyfj	27	5	residues	residue	NNS
cord-291950-9gtsqyfj	27	6	in	in	IN
cord-291950-9gtsqyfj	27	7	the	the	DT
cord-291950-9gtsqyfj	27	8	sequence	sequence	NN
cord-291950-9gtsqyfj	27	9	is	be	VBZ
cord-291950-9gtsqyfj	27	10	Gln	Gln	NNP
cord-291950-9gtsqyfj	27	11	,	,	,
cord-291950-9gtsqyfj	27	12	Cys	Cys	NNP
cord-291950-9gtsqyfj	27	13	,	,	,
cord-291950-9gtsqyfj	27	14	His	-PRON-	PRP$
cord-291950-9gtsqyfj	27	15	,	,	,
cord-291950-9gtsqyfj	27	16	Asn	Asn	NNP
cord-291950-9gtsqyfj	27	17	/	/	SYM
cord-291950-9gtsqyfj	27	18	Asp	Asp	NNP
cord-291950-9gtsqyfj	27	19	,	,	,
cord-291950-9gtsqyfj	27	20	and	and	CC
cord-291950-9gtsqyfj	27	21	in	in	IN
cord-291950-9gtsqyfj	27	22	mature	mature	JJ
cord-291950-9gtsqyfj	27	23	papain	papain	NN
cord-291950-9gtsqyfj	27	24	,	,	,
cord-291950-9gtsqyfj	27	25	the	the	DT
cord-291950-9gtsqyfj	27	26	numbering	numbering	NN
cord-291950-9gtsqyfj	27	27	is	be	VBZ
cord-291950-9gtsqyfj	27	28	Gln19	Gln19	NNP
cord-291950-9gtsqyfj	27	29	,	,	,
cord-291950-9gtsqyfj	27	30	Cys25	Cys25	NNP
cord-291950-9gtsqyfj	27	31	,	,	,
cord-291950-9gtsqyfj	27	32	His159	His159	NNP
cord-291950-9gtsqyfj	27	33	and	and	CC
cord-291950-9gtsqyfj	27	34	Asn175	Asn175	NNP
cord-291950-9gtsqyfj	27	35	.	.	.
cord-291950-9gtsqyfj	28	1	In	in	IN
cord-291950-9gtsqyfj	28	2	family	family	NN
cord-291950-9gtsqyfj	28	3	C19	C19	NNP
cord-291950-9gtsqyfj	28	4	,	,	,
cord-291950-9gtsqyfj	28	5	asparagine	asparagine	NN
cord-291950-9gtsqyfj	28	6	serves	serve	VBZ
cord-291950-9gtsqyfj	28	7	the	the	DT
cord-291950-9gtsqyfj	28	8	same	same	JJ
cord-291950-9gtsqyfj	28	9	function	function	NN
cord-291950-9gtsqyfj	28	10	as	as	IN
cord-291950-9gtsqyfj	28	11	Gln152	gln152	ADD
cord-291950-9gtsqyfj	28	12	.	.	.
cord-291950-9gtsqyfj	29	1	No	no	DT
cord-291950-9gtsqyfj	29	2	equivalent	equivalent	NN
cord-291950-9gtsqyfj	29	3	of	of	IN
cord-291950-9gtsqyfj	29	4	Gln152	gln152	NN
cord-291950-9gtsqyfj	29	5	has	have	VBZ
cord-291950-9gtsqyfj	29	6	been	be	VBN
cord-291950-9gtsqyfj	29	7	identified	identify	VBN
cord-291950-9gtsqyfj	29	8	in	in	IN
cord-291950-9gtsqyfj	29	9	the	the	DT
cord-291950-9gtsqyfj	29	10	foot	foot	NN
cord-291950-9gtsqyfj	29	11	-	-	HYPH
cord-291950-9gtsqyfj	29	12	and	and	CC
cord-291950-9gtsqyfj	29	13	-	-	HYPH
cord-291950-9gtsqyfj	29	14	mouth	mouth	NN
cord-291950-9gtsqyfj	29	15	disease	disease	NN
cord-291950-9gtsqyfj	29	16	virus	virus	NN
cord-291950-9gtsqyfj	29	17	L	l	NN
cord-291950-9gtsqyfj	29	18	-	-	HYPH
cord-291950-9gtsqyfj	29	19	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	29	20	.	.	.
cord-291950-9gtsqyfj	30	1	The	the	DT
cord-291950-9gtsqyfj	30	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	30	3	cysteine	cysteine	NN
cord-291950-9gtsqyfj	30	4	is	be	VBZ
cord-291950-9gtsqyfj	30	5	usually	usually	RB
cord-291950-9gtsqyfj	30	6	followed	follow	VBN
cord-291950-9gtsqyfj	30	7	by	by	IN
cord-291950-9gtsqyfj	30	8	an	an	DT
cord-291950-9gtsqyfj	30	9	aromatic	aromatic	JJ
cord-291950-9gtsqyfj	30	10	,	,	,
cord-291950-9gtsqyfj	30	11	hydrophobic	hydrophobic	JJ
cord-291950-9gtsqyfj	30	12	amino	amino	NN
cord-291950-9gtsqyfj	30	13	acid	acid	NN
cord-291950-9gtsqyfj	30	14	,	,	,
cord-291950-9gtsqyfj	30	15	but	but	CC
cord-291950-9gtsqyfj	30	16	glycine	glycine	NN
cord-291950-9gtsqyfj	30	17	occupies	occupy	VBZ
cord-291950-9gtsqyfj	30	18	this	this	DT
cord-291950-9gtsqyfj	30	19	position	position	NN
cord-291950-9gtsqyfj	30	20	in	in	IN
cord-291950-9gtsqyfj	30	21	some	some	DT
cord-291950-9gtsqyfj	30	22	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	30	23	of	of	IN
cord-291950-9gtsqyfj	30	24	family	family	NN
cord-291950-9gtsqyfj	30	25	C2	C2	NNP
cord-291950-9gtsqyfj	30	26	and	and	CC
cord-291950-9gtsqyfj	30	27	all	all	PDT
cord-291950-9gtsqyfj	30	28	those	those	DT
cord-291950-9gtsqyfj	30	29	of	of	IN
cord-291950-9gtsqyfj	30	30	family	family	NN
cord-291950-9gtsqyfj	30	31	C12	C12	NNP
cord-291950-9gtsqyfj	30	32	.	.	.
cord-291950-9gtsqyfj	31	1	Figure	figure	NN
cord-291950-9gtsqyfj	31	2	404	404	CD
cord-291950-9gtsqyfj	31	3	.8	.8	NFP
cord-291950-9gtsqyfj	31	4	shows	show	VBZ
cord-291950-9gtsqyfj	31	5	secondary	secondary	JJ
cord-291950-9gtsqyfj	31	6	structure	structure	NN
cord-291950-9gtsqyfj	31	7	diagrams	diagram	NNS
cord-291950-9gtsqyfj	31	8	of	of	IN
cord-291950-9gtsqyfj	31	9	example	example	NN
cord-291950-9gtsqyfj	31	10	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	31	11	from	from	IN
cord-291950-9gtsqyfj	31	12	the	the	DT
cord-291950-9gtsqyfj	31	13	clan	clan	NN
cord-291950-9gtsqyfj	31	14	.	.	.
cord-291950-9gtsqyfj	32	1	All	all	PDT
cord-291950-9gtsqyfj	32	2	the	the	DT
cord-291950-9gtsqyfj	32	3	examples	example	NNS
cord-291950-9gtsqyfj	32	4	shown	show	VBN
cord-291950-9gtsqyfj	32	5	are	be	VBP
cord-291950-9gtsqyfj	32	6	α	α	NN
cord-291950-9gtsqyfj	32	7	/	/	SYM
cord-291950-9gtsqyfj	32	8	β	β	NN
cord-291950-9gtsqyfj	32	9	proteins	protein	NNS
cord-291950-9gtsqyfj	32	10	,	,	,
cord-291950-9gtsqyfj	32	11	and	and	CC
cord-291950-9gtsqyfj	32	12	all	all	DT
cord-291950-9gtsqyfj	32	13	have	have	VBP
cord-291950-9gtsqyfj	32	14	the	the	DT
cord-291950-9gtsqyfj	32	15	nucleophilic	nucleophilic	JJ
cord-291950-9gtsqyfj	32	16	Cys	Cys	NNP
cord-291950-9gtsqyfj	32	17	at	at	IN
cord-291950-9gtsqyfj	32	18	the	the	DT
cord-291950-9gtsqyfj	32	19	start	start	NN
cord-291950-9gtsqyfj	32	20	of	of	IN
cord-291950-9gtsqyfj	32	21	a	a	DT
cord-291950-9gtsqyfj	32	22	helix	helix	NN
cord-291950-9gtsqyfj	32	23	and	and	CC
cord-291950-9gtsqyfj	32	24	the	the	DT
cord-291950-9gtsqyfj	32	25	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	33	1	His	-PRON-	PRP$
cord-291950-9gtsqyfj	33	2	at	at	IN
cord-291950-9gtsqyfj	33	3	the	the	DT
cord-291950-9gtsqyfj	33	4	start	start	NN
cord-291950-9gtsqyfj	33	5	of	of	IN
cord-291950-9gtsqyfj	33	6	a	a	DT
cord-291950-9gtsqyfj	33	7	β	β	NN
cord-291950-9gtsqyfj	33	8	-	-	HYPH
cord-291950-9gtsqyfj	33	9	sheet	sheet	NN
cord-291950-9gtsqyfj	33	10	.	.	.
cord-291950-9gtsqyfj	34	1	Inhibitors	inhibitor	NNS
cord-291950-9gtsqyfj	34	2	are	be	VBP
cord-291950-9gtsqyfj	34	3	of	of	IN
cord-291950-9gtsqyfj	34	4	some	some	DT
cord-291950-9gtsqyfj	34	5	use	use	NN
cord-291950-9gtsqyfj	34	6	in	in	IN
cord-291950-9gtsqyfj	34	7	identifying	identify	VBG
cord-291950-9gtsqyfj	34	8	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	34	9	of	of	IN
cord-291950-9gtsqyfj	34	10	clan	clan	NN
cord-291950-9gtsqyfj	34	11	CA	CA	NNP
cord-291950-9gtsqyfj	34	12	.	.	.
cord-291950-9gtsqyfj	35	1	Many	many	JJ
cord-291950-9gtsqyfj	35	2	members	member	NNS
cord-291950-9gtsqyfj	35	3	of	of	IN
cord-291950-9gtsqyfj	35	4	the	the	DT
cord-291950-9gtsqyfj	35	5	clan	clan	NN
cord-291950-9gtsqyfj	35	6	are	be	VBP
cord-291950-9gtsqyfj	35	7	irreversibly	irreversibly	RB
cord-291950-9gtsqyfj	35	8	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	35	9	by	by	IN
cord-291950-9gtsqyfj	35	10	compound	compound	NN
cord-291950-9gtsqyfj	35	11	E-64	E-64	NNP
cord-291950-9gtsqyfj	35	12	,	,	,
cord-291950-9gtsqyfj	35	13	but	but	CC
cord-291950-9gtsqyfj	35	14	reversible	reversible	JJ
cord-291950-9gtsqyfj	35	15	inhibition	inhibition	NN
cord-291950-9gtsqyfj	35	16	by	by	IN
cord-291950-9gtsqyfj	35	17	the	the	DT
cord-291950-9gtsqyfj	35	18	arginine	arginine	NN
cord-291950-9gtsqyfj	35	19	-	-	HYPH
cord-291950-9gtsqyfj	35	20	like	like	JJ
cord-291950-9gtsqyfj	35	21	side	side	NN
cord-291950-9gtsqyfj	35	22	chain	chain	NN
cord-291950-9gtsqyfj	35	23	of	of	IN
cord-291950-9gtsqyfj	35	24	E-64	E-64	NNP
cord-291950-9gtsqyfj	35	25	is	be	VBZ
cord-291950-9gtsqyfj	35	26	not	not	RB
cord-291950-9gtsqyfj	35	27	significant	significant	JJ
cord-291950-9gtsqyfj	35	28	and	and	CC
cord-291950-9gtsqyfj	35	29	should	should	MD
cord-291950-9gtsqyfj	35	30	be	be	VB
cord-291950-9gtsqyfj	35	31	ignored	ignore	VBN
cord-291950-9gtsqyfj	35	32	.	.	.
cord-291950-9gtsqyfj	36	1	Proteins	protein	NNS
cord-291950-9gtsqyfj	36	2	of	of	IN
cord-291950-9gtsqyfj	36	3	the	the	DT
cord-291950-9gtsqyfj	36	4	cystatin	cystatin	JJ
cord-291950-9gtsqyfj	36	5	family	family	NN
cord-291950-9gtsqyfj	36	6	also	also	RB
cord-291950-9gtsqyfj	36	7	inhibit	inhibit	VBP
cord-291950-9gtsqyfj	36	8	many	many	JJ
cord-291950-9gtsqyfj	36	9	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	36	10	in	in	IN
cord-291950-9gtsqyfj	36	11	clan	clan	NN
cord-291950-9gtsqyfj	36	12	CA	CA	NNP
cord-291950-9gtsqyfj	36	13	,	,	,
cord-291950-9gtsqyfj	36	14	but	but	CC
cord-291950-9gtsqyfj	36	15	it	-PRON-	PRP
cord-291950-9gtsqyfj	36	16	should	should	MD
cord-291950-9gtsqyfj	36	17	be	be	VB
cord-291950-9gtsqyfj	36	18	noted	note	VBN
cord-291950-9gtsqyfj	36	19	that	that	IN
cord-291950-9gtsqyfj	36	20	some	some	DT
cord-291950-9gtsqyfj	36	21	cystatins	cystatin	NNS
cord-291950-9gtsqyfj	36	22	have	have	VBP
cord-291950-9gtsqyfj	36	23	a	a	DT
cord-291950-9gtsqyfj	36	24	second	second	JJ
cord-291950-9gtsqyfj	36	25	reactive	reactive	JJ
cord-291950-9gtsqyfj	36	26	site	site	NN
cord-291950-9gtsqyfj	36	27	that	that	WDT
cord-291950-9gtsqyfj	36	28	can	can	MD
cord-291950-9gtsqyfj	36	29	inhibit	inhibit	VB
cord-291950-9gtsqyfj	36	30	legumain	legumain	NN
cord-291950-9gtsqyfj	36	31	,	,	,
cord-291950-9gtsqyfj	36	32	a	a	DT
cord-291950-9gtsqyfj	36	33	clan	clan	NN
cord-291950-9gtsqyfj	36	34	CD	cd	NN
cord-291950-9gtsqyfj	36	35	peptidase	peptidase	NN
cord-291950-9gtsqyfj	36	36	[	[	-LRB-
cord-291950-9gtsqyfj	36	37	1	1	CD
cord-291950-9gtsqyfj	36	38	]	]	-RRB-
cord-291950-9gtsqyfj	36	39	,	,	,
cord-291950-9gtsqyfj	36	40	and	and	CC
cord-291950-9gtsqyfj	36	41	some	some	DT
cord-291950-9gtsqyfj	36	42	cystatins	cystatin	NNS
cord-291950-9gtsqyfj	36	43	can	can	MD
cord-291950-9gtsqyfj	36	44	inhibit	inhibit	VB
cord-291950-9gtsqyfj	36	45	metallopeptidases	metallopeptidase	NNS
cord-291950-9gtsqyfj	36	46	[	[	-LRB-
cord-291950-9gtsqyfj	36	47	2	2	CD
cord-291950-9gtsqyfj	36	48	]	]	-RRB-
cord-291950-9gtsqyfj	36	49	.	.	.
cord-291950-9gtsqyfj	37	1	Family	family	NN
cord-291950-9gtsqyfj	37	2	C1	C1	NNP
cord-291950-9gtsqyfj	37	3	.	.	.
cord-291950-9gtsqyfj	38	1	The	the	DT
cord-291950-9gtsqyfj	38	2	evolutionary	evolutionary	JJ
cord-291950-9gtsqyfj	38	3	tree	tree	NN
cord-291950-9gtsqyfj	38	4	(	(	-LRB-
cord-291950-9gtsqyfj	38	5	see	see	VB
cord-291950-9gtsqyfj	38	6	the	the	DT
cord-291950-9gtsqyfj	38	7	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	38	8	database	database	NN
cord-291950-9gtsqyfj	38	9	)	)	-RRB-
cord-291950-9gtsqyfj	38	10	shows	show	VBZ
cord-291950-9gtsqyfj	38	11	that	that	IN
cord-291950-9gtsqyfj	38	12	the	the	DT
cord-291950-9gtsqyfj	38	13	family	family	NN
cord-291950-9gtsqyfj	38	14	is	be	VBZ
cord-291950-9gtsqyfj	38	15	divided	divide	VBN
cord-291950-9gtsqyfj	38	16	into	into	IN
cord-291950-9gtsqyfj	38	17	two	two	CD
cord-291950-9gtsqyfj	38	18	subfamilies	subfamily	NNS
cord-291950-9gtsqyfj	38	19	,	,	,
cord-291950-9gtsqyfj	38	20	C1A	c1a	NN
cord-291950-9gtsqyfj	38	21	(	(	-LRB-
cord-291950-9gtsqyfj	38	22	or	or	CC
cord-291950-9gtsqyfj	38	23	papain	papain	NN
cord-291950-9gtsqyfj	38	24	subfamily	subfamily	NN
cord-291950-9gtsqyfj	38	25	)	)	-RRB-
cord-291950-9gtsqyfj	38	26	and	and	CC
cord-291950-9gtsqyfj	38	27	C1B	c1b	NN
cord-291950-9gtsqyfj	38	28	(	(	-LRB-
cord-291950-9gtsqyfj	38	29	or	or	CC
cord-291950-9gtsqyfj	38	30	bleomycin	bleomycin	VB
cord-291950-9gtsqyfj	38	31	hydrolase	hydrolase	NNP
cord-291950-9gtsqyfj	38	32	subfamily	subfamily	NN
cord-291950-9gtsqyfj	38	33	)	)	-RRB-
cord-291950-9gtsqyfj	38	34	.	.	.
cord-291950-9gtsqyfj	39	1	It	-PRON-	PRP
cord-291950-9gtsqyfj	39	2	may	may	MD
cord-291950-9gtsqyfj	39	3	well	well	RB
cord-291950-9gtsqyfj	39	4	be	be	VB
cord-291950-9gtsqyfj	39	5	that	that	IN
cord-291950-9gtsqyfj	39	6	a	a	DT
cord-291950-9gtsqyfj	39	7	peptidase	peptidase	NN
cord-291950-9gtsqyfj	39	8	of	of	IN
cord-291950-9gtsqyfj	39	9	family	family	NN
cord-291950-9gtsqyfj	39	10	C1	C1	NNP
cord-291950-9gtsqyfj	39	11	was	be	VBD
cord-291950-9gtsqyfj	39	12	present	present	JJ
cord-291950-9gtsqyfj	39	13	in	in	IN
cord-291950-9gtsqyfj	39	14	the	the	DT
cord-291950-9gtsqyfj	39	15	universal	universal	JJ
cord-291950-9gtsqyfj	39	16	ancestor	ancestor	NN
cord-291950-9gtsqyfj	39	17	of	of	IN
cord-291950-9gtsqyfj	39	18	all	all	DT
cord-291950-9gtsqyfj	39	19	organisms	organism	NNS
cord-291950-9gtsqyfj	39	20	,	,	,
cord-291950-9gtsqyfj	39	21	and	and	CC
cord-291950-9gtsqyfj	39	22	that	that	IN
cord-291950-9gtsqyfj	39	23	this	this	DT
cord-291950-9gtsqyfj	39	24	evolved	evolve	VBD
cord-291950-9gtsqyfj	39	25	into	into	IN
cord-291950-9gtsqyfj	39	26	a	a	DT
cord-291950-9gtsqyfj	39	27	subfamily	subfamily	NN
cord-291950-9gtsqyfj	39	28	C1A	c1a	NN
cord-291950-9gtsqyfj	39	29	-	-	HYPH
cord-291950-9gtsqyfj	39	30	type	type	NN
cord-291950-9gtsqyfj	39	31	protein	protein	NN
cord-291950-9gtsqyfj	39	32	in	in	IN
cord-291950-9gtsqyfj	39	33	early	early	JJ
cord-291950-9gtsqyfj	39	34	archaea	archaea	NNS
cord-291950-9gtsqyfj	39	35	and	and	CC
cord-291950-9gtsqyfj	39	36	a	a	DT
cord-291950-9gtsqyfj	39	37	subfamily	subfamily	NN
cord-291950-9gtsqyfj	39	38	C1B	c1b	NN
cord-291950-9gtsqyfj	39	39	-	-	HYPH
cord-291950-9gtsqyfj	39	40	type	type	NN
cord-291950-9gtsqyfj	39	41	protein	protein	NN
cord-291950-9gtsqyfj	39	42	in	in	IN
cord-291950-9gtsqyfj	39	43	early	early	JJ
cord-291950-9gtsqyfj	39	44	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	39	45	.	.	.
cord-291950-9gtsqyfj	40	1	Further	further	JJ
cord-291950-9gtsqyfj	40	2	divergence	divergence	NN
cord-291950-9gtsqyfj	40	3	would	would	MD
cord-291950-9gtsqyfj	40	4	have	have	VB
cord-291950-9gtsqyfj	40	5	occurred	occur	VBN
cord-291950-9gtsqyfj	40	6	in	in	IN
cord-291950-9gtsqyfj	40	7	the	the	DT
cord-291950-9gtsqyfj	40	8	separate	separate	JJ
cord-291950-9gtsqyfj	40	9	groups	group	NNS
cord-291950-9gtsqyfj	40	10	of	of	IN
cord-291950-9gtsqyfj	40	11	organisms	organism	NNS
cord-291950-9gtsqyfj	40	12	,	,	,
cord-291950-9gtsqyfj	40	13	and	and	CC
cord-291950-9gtsqyfj	40	14	horizontal	horizontal	JJ
cord-291950-9gtsqyfj	40	15	transfers	transfer	NNS
cord-291950-9gtsqyfj	40	16	can	can	MD
cord-291950-9gtsqyfj	40	17	explain	explain	VB
cord-291950-9gtsqyfj	40	18	the	the	DT
cord-291950-9gtsqyfj	40	19	presence	presence	NN
cord-291950-9gtsqyfj	40	20	of	of	IN
cord-291950-9gtsqyfj	40	21	a	a	DT
cord-291950-9gtsqyfj	40	22	C1A	c1a	NN
cord-291950-9gtsqyfj	40	23	homolog	homolog	NN
cord-291950-9gtsqyfj	40	24	in	in	IN
cord-291950-9gtsqyfj	40	25	Clostridium	clostridium	NN
cord-291950-9gtsqyfj	40	26	and	and	CC
cord-291950-9gtsqyfj	40	27	of	of	IN
cord-291950-9gtsqyfj	40	28	bleomycin	bleomycin	NN
cord-291950-9gtsqyfj	40	29	hydrolase	hydrolase	NN
cord-291950-9gtsqyfj	40	30	in	in	IN
cord-291950-9gtsqyfj	40	31	eukaryotes	eukaryote	NNS
cord-291950-9gtsqyfj	40	32	.	.	.
cord-291950-9gtsqyfj	41	1	Subfamily	Subfamily	NNP
cord-291950-9gtsqyfj	41	2	C1A	c1a	NN
cord-291950-9gtsqyfj	41	3	is	be	VBZ
cord-291950-9gtsqyfj	41	4	the	the	DT
cord-291950-9gtsqyfj	41	5	larger	large	JJR
cord-291950-9gtsqyfj	41	6	of	of	IN
cord-291950-9gtsqyfj	41	7	these	these	DT
cord-291950-9gtsqyfj	41	8	subunits	subunit	NNS
cord-291950-9gtsqyfj	41	9	,	,	,
cord-291950-9gtsqyfj	41	10	and	and	CC
cord-291950-9gtsqyfj	41	11	consists	consist	VBZ
cord-291950-9gtsqyfj	41	12	of	of	IN
cord-291950-9gtsqyfj	41	13	secreted	secrete	VBN
cord-291950-9gtsqyfj	41	14	and	and	CC
cord-291950-9gtsqyfj	41	15	lysosomal	lysosomal	JJ
cord-291950-9gtsqyfj	41	16	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	41	17	.	.	.
cord-291950-9gtsqyfj	42	1	Subfamily	Subfamily	NNP
cord-291950-9gtsqyfj	42	2	C1A	c1a	NN
cord-291950-9gtsqyfj	42	3	contains	contain	VBZ
cord-291950-9gtsqyfj	42	4	mainly	mainly	RB
cord-291950-9gtsqyfj	42	5	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	42	6	from	from	IN
cord-291950-9gtsqyfj	42	7	DNA	dna	NN
cord-291950-9gtsqyfj	42	8	viruses	virus	NNS
cord-291950-9gtsqyfj	42	9	,	,	,
cord-291950-9gtsqyfj	42	10	protozoa	protozoan	NNS
cord-291950-9gtsqyfj	42	11	,	,	,
cord-291950-9gtsqyfj	42	12	plants	plant	NNS
cord-291950-9gtsqyfj	42	13	and	and	CC
cord-291950-9gtsqyfj	42	14	animals	animal	NNS
cord-291950-9gtsqyfj	42	15	,	,	,
cord-291950-9gtsqyfj	42	16	and	and	CC
cord-291950-9gtsqyfj	42	17	exopeptidases	exopeptidase	NNS
cord-291950-9gtsqyfj	42	18	from	from	IN
cord-291950-9gtsqyfj	42	19	gram	gram	NN
cord-291950-9gtsqyfj	42	20	-	-	HYPH
cord-291950-9gtsqyfj	42	21	positive	positive	JJ
cord-291950-9gtsqyfj	42	22	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	42	23	,	,	,
cord-291950-9gtsqyfj	42	24	fungi	fungus	NNS
cord-291950-9gtsqyfj	42	25	and	and	CC
cord-291950-9gtsqyfj	42	26	animals	animal	NNS
cord-291950-9gtsqyfj	42	27	.	.	.
cord-291950-9gtsqyfj	43	1	Members	member	NNS
cord-291950-9gtsqyfj	43	2	but	but	CC
cord-291950-9gtsqyfj	43	3	the	the	DT
cord-291950-9gtsqyfj	43	4	majority	majority	NN
cord-291950-9gtsqyfj	43	5	of	of	IN
cord-291950-9gtsqyfj	43	6	completed	complete	VBN
cord-291950-9gtsqyfj	43	7	archaean	archaean	JJ
cord-291950-9gtsqyfj	43	8	genomes	genome	NNS
cord-291950-9gtsqyfj	43	9	lack	lack	VBP
cord-291950-9gtsqyfj	43	10	C1A	c1a	NN
cord-291950-9gtsqyfj	43	11	homologs	homolog	NNS
cord-291950-9gtsqyfj	43	12	.	.	.
cord-291950-9gtsqyfj	44	1	Homologs	Homologs	NNP
cord-291950-9gtsqyfj	44	2	are	be	VBP
cord-291950-9gtsqyfj	44	3	patchily	patchily	RB
cord-291950-9gtsqyfj	44	4	distributed	distribute	VBN
cord-291950-9gtsqyfj	44	5	in	in	IN
cord-291950-9gtsqyfj	44	6	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	44	7	,	,	,
cord-291950-9gtsqyfj	44	8	with	with	IN
cord-291950-9gtsqyfj	44	9	most	most	JJS
cord-291950-9gtsqyfj	44	10	genomes	genome	NNS
cord-291950-9gtsqyfj	44	11	lacking	lack	VBG
cord-291950-9gtsqyfj	44	12	a	a	DT
cord-291950-9gtsqyfj	44	13	homolog	homolog	NN
cord-291950-9gtsqyfj	44	14	.	.	.
cord-291950-9gtsqyfj	45	1	Most	Most	JJS
cord-291950-9gtsqyfj	45	2	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	45	3	homologs	homolog	NNS
cord-291950-9gtsqyfj	45	4	are	be	VBP
cord-291950-9gtsqyfj	45	5	from	from	IN
cord-291950-9gtsqyfj	45	6	members	member	NNS
cord-291950-9gtsqyfj	45	7	of	of	IN
cord-291950-9gtsqyfj	45	8	the	the	DT
cord-291950-9gtsqyfj	45	9	phyla	phylum	NNS
cord-291950-9gtsqyfj	45	10	Bacteroidetes	Bacteroidetes	NNPS
cord-291950-9gtsqyfj	45	11	and	and	CC
cord-291950-9gtsqyfj	45	12	Chloroflexi	Chloroflexi	NNP
cord-291950-9gtsqyfj	45	13	.	.	.
cord-291950-9gtsqyfj	46	1	Even	even	RB
cord-291950-9gtsqyfj	46	2	within	within	IN
cord-291950-9gtsqyfj	46	3	a	a	DT
cord-291950-9gtsqyfj	46	4	genus	genus	NN
cord-291950-9gtsqyfj	46	5	,	,	,
cord-291950-9gtsqyfj	46	6	some	some	DT
cord-291950-9gtsqyfj	46	7	species	specie	NNS
cord-291950-9gtsqyfj	46	8	will	will	MD
cord-291950-9gtsqyfj	46	9	possess	possess	VB
cord-291950-9gtsqyfj	46	10	a	a	DT
cord-291950-9gtsqyfj	46	11	homolog	homolog	NN
cord-291950-9gtsqyfj	46	12	and	and	CC
cord-291950-9gtsqyfj	46	13	some	some	DT
cord-291950-9gtsqyfj	46	14	will	will	MD
cord-291950-9gtsqyfj	46	15	not	not	RB
cord-291950-9gtsqyfj	46	16	;	;	:
cord-291950-9gtsqyfj	46	17	for	for	IN
cord-291950-9gtsqyfj	46	18	example	example	NN
cord-291950-9gtsqyfj	46	19	,	,	,
cord-291950-9gtsqyfj	46	20	half	half	NN
cord-291950-9gtsqyfj	46	21	of	of	IN
cord-291950-9gtsqyfj	46	22	the	the	DT
cord-291950-9gtsqyfj	46	23	Mycoplasma	Mycoplasma	NNP
cord-291950-9gtsqyfj	46	24	species	specie	NNS
cord-291950-9gtsqyfj	46	25	with	with	IN
cord-291950-9gtsqyfj	46	26	completed	complete	VBN
cord-291950-9gtsqyfj	46	27	genomes	genome	NNS
cord-291950-9gtsqyfj	46	28	have	have	VBP
cord-291950-9gtsqyfj	46	29	homologs	homolog	NNS
cord-291950-9gtsqyfj	46	30	.	.	.
cord-291950-9gtsqyfj	47	1	The	the	DT
cord-291950-9gtsqyfj	47	2	subfamily	subfamily	NN
cord-291950-9gtsqyfj	47	3	includes	include	VBZ
cord-291950-9gtsqyfj	47	4	the	the	DT
cord-291950-9gtsqyfj	47	5	plant	plant	NN
cord-291950-9gtsqyfj	47	6	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	47	7	papain	papain	NN
cord-291950-9gtsqyfj	47	8	,	,	,
cord-291950-9gtsqyfj	47	9	chymopapain	chymopapain	NNP
cord-291950-9gtsqyfj	47	10	and	and	CC
cord-291950-9gtsqyfj	47	11	actinidain	actinidain	NNP
cord-291950-9gtsqyfj	47	12	,	,	,
cord-291950-9gtsqyfj	47	13	and	and	CC
cord-291950-9gtsqyfj	47	14	the	the	DT
cord-291950-9gtsqyfj	47	15	animal	animal	NN
cord-291950-9gtsqyfj	47	16	lysosomal	lysosomal	NN
cord-291950-9gtsqyfj	47	17	enzymes	enzymes	VBP
cord-291950-9gtsqyfj	47	18	cathepsins	cathepsin	NNS
cord-291950-9gtsqyfj	47	19	B	B	NNP
cord-291950-9gtsqyfj	47	20	,	,	,
cord-291950-9gtsqyfj	47	21	H	H	NNP
cord-291950-9gtsqyfj	47	22	and	and	CC
cord-291950-9gtsqyfj	47	23	L.	L.	NNP
cord-291950-9gtsqyfj	47	24	Figure	Figure	NNP
cord-291950-9gtsqyfj	47	25	404	404	CD
cord-291950-9gtsqyfj	47	26	.1	.1	NNS
cord-291950-9gtsqyfj	47	27	shows	show	VBZ
cord-291950-9gtsqyfj	47	28	the	the	DT
cord-291950-9gtsqyfj	47	29	three	three	CD
cord-291950-9gtsqyfj	47	30	-	-	HYPH
cord-291950-9gtsqyfj	47	31	dimensional	dimensional	JJ
cord-291950-9gtsqyfj	47	32	structure	structure	NN
cord-291950-9gtsqyfj	47	33	of	of	IN
cord-291950-9gtsqyfj	47	34	papain	papain	NN
cord-291950-9gtsqyfj	47	35	.	.	.
cord-291950-9gtsqyfj	48	1	There	there	EX
cord-291950-9gtsqyfj	48	2	is	be	VBZ
cord-291950-9gtsqyfj	48	3	a	a	DT
cord-291950-9gtsqyfj	48	4	clear	clear	JJ
cord-291950-9gtsqyfj	48	5	division	division	NN
cord-291950-9gtsqyfj	48	6	within	within	IN
cord-291950-9gtsqyfj	48	7	the	the	DT
cord-291950-9gtsqyfj	48	8	subfamily	subfamily	NN
cord-291950-9gtsqyfj	48	9	between	between	IN
cord-291950-9gtsqyfj	48	10	the	the	DT
cord-291950-9gtsqyfj	48	11	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	48	12	B	b	NN
cord-291950-9gtsqyfj	48	13	-	-	HYPH
cord-291950-9gtsqyfj	48	14	like	like	JJ
cord-291950-9gtsqyfj	48	15	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	48	16	and	and	CC
cord-291950-9gtsqyfj	48	17	the	the	DT
cord-291950-9gtsqyfj	48	18	papain	papain	NN
cord-291950-9gtsqyfj	48	19	-	-	HYPH
cord-291950-9gtsqyfj	48	20	like	like	JJ
cord-291950-9gtsqyfj	48	21	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	48	22	.	.	.
cord-291950-9gtsqyfj	49	1	Among	among	IN
cord-291950-9gtsqyfj	49	2	the	the	DT
cord-291950-9gtsqyfj	49	3	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	49	4	B	b	NN
cord-291950-9gtsqyfj	49	5	-	-	HYPH
cord-291950-9gtsqyfj	49	6	like	like	JJ
cord-291950-9gtsqyfj	49	7	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	49	8	are	be	VBP
cord-291950-9gtsqyfj	49	9	dipeptidyl	dipeptidyl	JJ
cord-291950-9gtsqyfj	49	10	-	-	HYPH
cord-291950-9gtsqyfj	49	11	peptidase	peptidase	NN
cord-291950-9gtsqyfj	49	12	I	I	NNP
cord-291950-9gtsqyfj	49	13	,	,	,
cord-291950-9gtsqyfj	49	14	and	and	CC
cord-291950-9gtsqyfj	49	15	the	the	DT
cord-291950-9gtsqyfj	49	16	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	49	17	from	from	IN
cord-291950-9gtsqyfj	49	18	Giardia	Giardia	NNP
cord-291950-9gtsqyfj	49	19	.	.	.
cord-291950-9gtsqyfj	50	1	Included	include	VBN
cord-291950-9gtsqyfj	50	2	among	among	IN
cord-291950-9gtsqyfj	50	3	the	the	DT
cord-291950-9gtsqyfj	50	4	papain	papain	NN
cord-291950-9gtsqyfj	50	5	-	-	HYPH
cord-291950-9gtsqyfj	50	6	like	like	JJ
cord-291950-9gtsqyfj	50	7	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	50	8	are	be	VBP
cord-291950-9gtsqyfj	51	1	cathepsins	cathepsins	NNP
cord-291950-9gtsqyfj	51	2	O	O	NNP
cord-291950-9gtsqyfj	51	3	,	,	,
cord-291950-9gtsqyfj	51	4	H	H	NNP
cord-291950-9gtsqyfj	51	5	,	,	,
cord-291950-9gtsqyfj	51	6	L	L	NNP
cord-291950-9gtsqyfj	51	7	,	,	,
cord-291950-9gtsqyfj	51	8	K	K	NNP
cord-291950-9gtsqyfj	51	9	and	and	CC
cord-291950-9gtsqyfj	51	10	S.	S.	NNP
cord-291950-9gtsqyfj	51	11	Cathepsin	Cathepsin	NNP
cord-291950-9gtsqyfj	52	1	O	o	UH
cord-291950-9gtsqyfj	52	2	is	be	VBZ
cord-291950-9gtsqyfj	52	3	very	very	RB
cord-291950-9gtsqyfj	52	4	divergent	divergent	JJ
cord-291950-9gtsqyfj	52	5	,	,	,
cord-291950-9gtsqyfj	52	6	whereas	whereas	IN
cord-291950-9gtsqyfj	52	7	the	the	DT
cord-291950-9gtsqyfj	52	8	others	other	NNS
cord-291950-9gtsqyfj	52	9	are	be	VBP
cord-291950-9gtsqyfj	52	10	more	more	RBR
cord-291950-9gtsqyfj	52	11	closely	closely	RB
cord-291950-9gtsqyfj	52	12	related	related	JJ
cord-291950-9gtsqyfj	52	13	.	.	.
cord-291950-9gtsqyfj	53	1	The	the	DT
cord-291950-9gtsqyfj	53	2	close	close	JJ
cord-291950-9gtsqyfj	53	3	relationship	relationship	NN
cord-291950-9gtsqyfj	53	4	between	between	IN
cord-291950-9gtsqyfj	53	5	mammalian	mammalian	JJ
cord-291950-9gtsqyfj	53	6	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	53	7	H	h	NN
cord-291950-9gtsqyfj	53	8	and	and	CC
cord-291950-9gtsqyfj	53	9	plant	plant	NN
cord-291950-9gtsqyfj	53	10	aleurain	aleurain	NNP
cord-291950-9gtsqyfj	53	11	is	be	VBZ
cord-291950-9gtsqyfj	53	12	apparent	apparent	JJ
cord-291950-9gtsqyfj	53	13	.	.	.
cord-291950-9gtsqyfj	54	1	The	the	DT
cord-291950-9gtsqyfj	54	2	distinction	distinction	NN
cord-291950-9gtsqyfj	54	3	between	between	IN
cord-291950-9gtsqyfj	54	4	exopeptidases	exopeptidase	NNS
cord-291950-9gtsqyfj	54	5	and	and	CC
cord-291950-9gtsqyfj	54	6	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	54	7	is	be	VBZ
cord-291950-9gtsqyfj	54	8	blurred	blur	VBN
cord-291950-9gtsqyfj	54	9	for	for	IN
cord-291950-9gtsqyfj	54	10	some	some	DT
cord-291950-9gtsqyfj	54	11	members	member	NNS
cord-291950-9gtsqyfj	54	12	of	of	IN
cord-291950-9gtsqyfj	54	13	subfamily	subfamily	NN
cord-291950-9gtsqyfj	54	14	C1A.	C1A.	VBN
cord-291950-9gtsqyfj	54	15	Dipeptidyl	Dipeptidyl	NNP
cord-291950-9gtsqyfj	54	16	-	-	HYPH
cord-291950-9gtsqyfj	54	17	peptidase	peptidase	NN
cord-291950-9gtsqyfj	54	18	I	i	NN
cord-291950-9gtsqyfj	54	19	(	(	-LRB-
cord-291950-9gtsqyfj	54	20	Chapter	chapter	NN
cord-291950-9gtsqyfj	54	21	447	447	CD
cord-291950-9gtsqyfj	54	22	)	)	-RRB-
cord-291950-9gtsqyfj	54	23	acts	act	VBZ
cord-291950-9gtsqyfj	54	24	principally	principally	RB
cord-291950-9gtsqyfj	54	25	as	as	IN
cord-291950-9gtsqyfj	54	26	an	an	DT
cord-291950-9gtsqyfj	54	27	exopeptidase	exopeptidase	NN
cord-291950-9gtsqyfj	54	28	,	,	,
cord-291950-9gtsqyfj	54	29	removing	remove	VBG
cord-291950-9gtsqyfj	54	30	N	n	CD
cord-291950-9gtsqyfj	54	31	-	-	HYPH
cord-291950-9gtsqyfj	54	32	terminal	terminal	NN
cord-291950-9gtsqyfj	54	33	dipeptides	dipeptide	NNS
cord-291950-9gtsqyfj	54	34	,	,	,
cord-291950-9gtsqyfj	54	35	but	but	CC
cord-291950-9gtsqyfj	54	36	may	may	MD
cord-291950-9gtsqyfj	54	37	have	have	VB
cord-291950-9gtsqyfj	54	38	limited	limited	JJ
cord-291950-9gtsqyfj	54	39	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	54	40	activity	activity	NN
cord-291950-9gtsqyfj	54	41	.	.	.
cord-291950-9gtsqyfj	55	1	Cathepsins	Cathepsins	NNPS
cord-291950-9gtsqyfj	55	2	B	B	NNP
cord-291950-9gtsqyfj	55	3	and	and	CC
cord-291950-9gtsqyfj	55	4	H	H	NNP
cord-291950-9gtsqyfj	55	5	(	(	-LRB-
cord-291950-9gtsqyfj	55	6	Chapters	chapter	NNS
cord-291950-9gtsqyfj	55	7	406	406	CD
cord-291950-9gtsqyfj	55	8	and	and	CC
cord-291950-9gtsqyfj	55	9	408	408	CD
cord-291950-9gtsqyfj	55	10	)	)	-RRB-
cord-291950-9gtsqyfj	55	11	both	both	DT
cord-291950-9gtsqyfj	55	12	possess	possess	VBP
cord-291950-9gtsqyfj	55	13	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	55	14	activity	activity	NN
cord-291950-9gtsqyfj	55	15	,	,	,
cord-291950-9gtsqyfj	55	16	but	but	CC
cord-291950-9gtsqyfj	55	17	arguably	arguably	RB
cord-291950-9gtsqyfj	55	18	are	be	VBP
cord-291950-9gtsqyfj	55	19	more	more	RBR
cord-291950-9gtsqyfj	55	20	important	important	JJ
cord-291950-9gtsqyfj	55	21	for	for	IN
cord-291950-9gtsqyfj	55	22	their	-PRON-	PRP$
cord-291950-9gtsqyfj	55	23	exopeptidase	exopeptidase	JJ
cord-291950-9gtsqyfj	55	24	activities	activity	NNS
cord-291950-9gtsqyfj	55	25	.	.	.
cord-291950-9gtsqyfj	56	1	Cathepsin	Cathepsin	NNP
cord-291950-9gtsqyfj	56	2	B	B	NNP
cord-291950-9gtsqyfj	56	3	acts	act	VBZ
cord-291950-9gtsqyfj	56	4	as	as	IN
cord-291950-9gtsqyfj	56	5	a	a	DT
cord-291950-9gtsqyfj	56	6	peptidyldipeptidase	peptidyldipeptidase	NN
cord-291950-9gtsqyfj	56	7	,	,	,
cord-291950-9gtsqyfj	56	8	releasing	release	VBG
cord-291950-9gtsqyfj	56	9	C	c	NN
cord-291950-9gtsqyfj	56	10	-	-	HYPH
cord-291950-9gtsqyfj	56	11	terminal	terminal	NN
cord-291950-9gtsqyfj	56	12	dipeptides	dipeptide	NNS
cord-291950-9gtsqyfj	56	13	,	,	,
cord-291950-9gtsqyfj	56	14	and	and	CC
cord-291950-9gtsqyfj	56	15	this	this	DT
cord-291950-9gtsqyfj	56	16	activity	activity	NN
cord-291950-9gtsqyfj	56	17	is	be	VBZ
cord-291950-9gtsqyfj	56	18	attributable	attributable	JJ
cord-291950-9gtsqyfj	56	19	to	to	IN
cord-291950-9gtsqyfj	56	20	the	the	DT
cord-291950-9gtsqyfj	56	21	existence	existence	NN
cord-291950-9gtsqyfj	56	22	of	of	IN
cord-291950-9gtsqyfj	56	23	an	an	DT
cord-291950-9gtsqyfj	56	24	extended	extended	JJ
cord-291950-9gtsqyfj	56	25	loop	loop	NN
cord-291950-9gtsqyfj	56	26	that	that	WDT
cord-291950-9gtsqyfj	56	27	forms	form	VBZ
cord-291950-9gtsqyfj	56	28	a	a	DT
cord-291950-9gtsqyfj	56	29	cap	cap	NN
cord-291950-9gtsqyfj	56	30	to	to	IN
cord-291950-9gtsqyfj	56	31	the	the	DT
cord-291950-9gtsqyfj	56	32	active	active	JJ
cord-291950-9gtsqyfj	56	33	-	-	HYPH
cord-291950-9gtsqyfj	56	34	site	site	NN
cord-291950-9gtsqyfj	56	35	cleft	cleft	NN
cord-291950-9gtsqyfj	56	36	,	,	,
cord-291950-9gtsqyfj	56	37	and	and	CC
cord-291950-9gtsqyfj	56	38	carries	carry	VBZ
cord-291950-9gtsqyfj	56	39	a	a	DT
cord-291950-9gtsqyfj	56	40	pair	pair	NN
cord-291950-9gtsqyfj	56	41	of	of	IN
cord-291950-9gtsqyfj	56	42	His	-PRON-	PRP$
cord-291950-9gtsqyfj	56	43	residues	residue	NNS
cord-291950-9gtsqyfj	56	44	that	that	WDT
cord-291950-9gtsqyfj	56	45	are	be	VBP
cord-291950-9gtsqyfj	56	46	thought	think	VBN
cord-291950-9gtsqyfj	56	47	to	to	TO
cord-291950-9gtsqyfj	56	48	bind	bind	VB
cord-291950-9gtsqyfj	56	49	the	the	DT
cord-291950-9gtsqyfj	56	50	C	c	NN
cord-291950-9gtsqyfj	56	51	-	-	HYPH
cord-291950-9gtsqyfj	56	52	terminal	terminal	NN
cord-291950-9gtsqyfj	56	53	carboxylate	carboxylate	NN
cord-291950-9gtsqyfj	56	54	of	of	IN
cord-291950-9gtsqyfj	56	55	the	the	DT
cord-291950-9gtsqyfj	56	56	substrate	substrate	NN
cord-291950-9gtsqyfj	56	57	(	(	-LRB-
cord-291950-9gtsqyfj	56	58	Figure	figure	NN
cord-291950-9gtsqyfj	56	59	404.9	404.9	CD
cord-291950-9gtsqyfj	56	60	)	)	-RRB-
cord-291950-9gtsqyfj	56	61	.	.	.
cord-291950-9gtsqyfj	57	1	Cathepsin	Cathepsin	NNP
cord-291950-9gtsqyfj	57	2	X	X	NNP
cord-291950-9gtsqyfj	57	3	is	be	VBZ
cord-291950-9gtsqyfj	57	4	a	a	DT
cord-291950-9gtsqyfj	57	5	rather	rather	RB
cord-291950-9gtsqyfj	57	6	specific	specific	JJ
cord-291950-9gtsqyfj	57	7	carboxypeptidase	carboxypeptidase	NN
cord-291950-9gtsqyfj	57	8	(	(	-LRB-
cord-291950-9gtsqyfj	57	9	Chapter	chapter	NN
cord-291950-9gtsqyfj	57	10	415	415	CD
cord-291950-9gtsqyfj	57	11	)	)	-RRB-
cord-291950-9gtsqyfj	57	12	.	.	.
cord-291950-9gtsqyfj	58	1	The	the	DT
cord-291950-9gtsqyfj	58	2	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	58	3	that	that	WDT
cord-291950-9gtsqyfj	58	4	enter	enter	VBP
cord-291950-9gtsqyfj	58	5	the	the	DT
cord-291950-9gtsqyfj	58	6	secretory	secretory	JJ
cord-291950-9gtsqyfj	58	7	pathway	pathway	NN
cord-291950-9gtsqyfj	58	8	,	,	,
cord-291950-9gtsqyfj	58	9	destined	destine	VBN
cord-291950-9gtsqyfj	58	10	either	either	CC
cord-291950-9gtsqyfj	58	11	for	for	IN
cord-291950-9gtsqyfj	58	12	secretion	secretion	NN
cord-291950-9gtsqyfj	58	13	or	or	CC
cord-291950-9gtsqyfj	58	14	for	for	IN
cord-291950-9gtsqyfj	58	15	the	the	DT
cord-291950-9gtsqyfj	58	16	lysosomal	lysosomal	JJ
cord-291950-9gtsqyfj	58	17	system	system	NN
cord-291950-9gtsqyfj	58	18	,	,	,
cord-291950-9gtsqyfj	58	19	are	be	VBP
cord-291950-9gtsqyfj	58	20	synthesized	synthesize	VBN
cord-291950-9gtsqyfj	58	21	as	as	IN
cord-291950-9gtsqyfj	58	22	precursors	precursor	NNS
cord-291950-9gtsqyfj	58	23	,	,	,
cord-291950-9gtsqyfj	58	24	with	with	IN
cord-291950-9gtsqyfj	58	25	N	n	CD
cord-291950-9gtsqyfj	58	26	-	-	HYPH
cord-291950-9gtsqyfj	58	27	terminal	terminal	NN
cord-291950-9gtsqyfj	58	28	propeptides	propeptide	NNS
cord-291950-9gtsqyfj	58	29	as	as	RB
cord-291950-9gtsqyfj	58	30	well	well	RB
cord-291950-9gtsqyfj	58	31	as	as	IN
cord-291950-9gtsqyfj	58	32	the	the	DT
cord-291950-9gtsqyfj	58	33	signal	signal	NN
cord-291950-9gtsqyfj	58	34	peptides	peptide	NNS
cord-291950-9gtsqyfj	58	35	.	.	.
cord-291950-9gtsqyfj	59	1	Most	Most	JJS
cord-291950-9gtsqyfj	59	2	members	member	NNS
cord-291950-9gtsqyfj	59	3	of	of	IN
cord-291950-9gtsqyfj	59	4	family	family	NN
cord-291950-9gtsqyfj	59	5	C1	C1	NNP
cord-291950-9gtsqyfj	59	6	have	have	VBP
cord-291950-9gtsqyfj	59	7	propeptides	propeptide	NNS
cord-291950-9gtsqyfj	59	8	homologous	homologous	JJ
cord-291950-9gtsqyfj	59	9	to	to	IN
cord-291950-9gtsqyfj	59	10	that	that	DT
cord-291950-9gtsqyfj	59	11	of	of	IN
cord-291950-9gtsqyfj	59	12	papain	papain	NN
cord-291950-9gtsqyfj	59	13	,	,	,
cord-291950-9gtsqyfj	59	14	but	but	CC
cord-291950-9gtsqyfj	59	15	the	the	DT
cord-291950-9gtsqyfj	59	16	propeptide	propeptide	NN
cord-291950-9gtsqyfj	59	17	of	of	IN
cord-291950-9gtsqyfj	59	18	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	59	19	B	B	NNP
cord-291950-9gtsqyfj	59	20	is	be	VBZ
cord-291950-9gtsqyfj	59	21	much	much	RB
cord-291950-9gtsqyfj	59	22	shorter	short	JJR
cord-291950-9gtsqyfj	59	23	and	and	CC
cord-291950-9gtsqyfj	59	24	very	very	RB
cord-291950-9gtsqyfj	59	25	different	different	JJ
cord-291950-9gtsqyfj	59	26	in	in	IN
cord-291950-9gtsqyfj	59	27	sequence	sequence	NN
cord-291950-9gtsqyfj	59	28	.	.	.
cord-291950-9gtsqyfj	60	1	However	however	RB
cord-291950-9gtsqyfj	60	2	,	,	,
cord-291950-9gtsqyfj	60	3	the	the	DT
cord-291950-9gtsqyfj	60	4	propeptides	propeptide	NNS
cord-291950-9gtsqyfj	60	5	of	of	IN
cord-291950-9gtsqyfj	60	6	both	both	DT
cord-291950-9gtsqyfj	60	7	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	60	8	B	b	NN
cord-291950-9gtsqyfj	60	9	and	and	CC
cord-291950-9gtsqyfj	60	10	papain	papain	NN
cord-291950-9gtsqyfj	60	11	are	be	VBP
cord-291950-9gtsqyfj	60	12	thought	think	VBN
cord-291950-9gtsqyfj	60	13	to	to	TO
cord-291950-9gtsqyfj	60	14	act	act	VB
cord-291950-9gtsqyfj	60	15	in	in	IN
cord-291950-9gtsqyfj	60	16	the	the	DT
cord-291950-9gtsqyfj	60	17	same	same	JJ
cord-291950-9gtsqyfj	60	18	way	way	NN
cord-291950-9gtsqyfj	60	19	in	in	IN
cord-291950-9gtsqyfj	60	20	the	the	DT
cord-291950-9gtsqyfj	60	21	proenzymes	proenzyme	NNS
cord-291950-9gtsqyfj	60	22	,	,	,
cord-291950-9gtsqyfj	60	23	blocking	block	VBG
cord-291950-9gtsqyfj	60	24	the	the	DT
cord-291950-9gtsqyfj	60	25	active	active	JJ
cord-291950-9gtsqyfj	60	26	site	site	NN
cord-291950-9gtsqyfj	60	27	by	by	IN
cord-291950-9gtsqyfj	60	28	being	be	VBG
cord-291950-9gtsqyfj	60	29	bound	bind	VBN
cord-291950-9gtsqyfj	60	30	in	in	IN
cord-291950-9gtsqyfj	60	31	the	the	DT
cord-291950-9gtsqyfj	60	32	reverse	reverse	JJ
cord-291950-9gtsqyfj	60	33	orientation	orientation	NN
cord-291950-9gtsqyfj	60	34	to	to	IN
cord-291950-9gtsqyfj	60	35	a	a	DT
cord-291950-9gtsqyfj	60	36	substrate	substrate	NN
cord-291950-9gtsqyfj	60	37	,	,	,
cord-291950-9gtsqyfj	60	38	as	as	IN
cord-291950-9gtsqyfj	60	39	can	can	MD
cord-291950-9gtsqyfj	60	40	be	be	VB
cord-291950-9gtsqyfj	60	41	seen	see	VBN
cord-291950-9gtsqyfj	60	42	from	from	IN
cord-291950-9gtsqyfj	60	43	the	the	DT
cord-291950-9gtsqyfj	60	44	structure	structure	NN
cord-291950-9gtsqyfj	60	45	of	of	IN
cord-291950-9gtsqyfj	60	46	procathepsin	procathepsin	NNP
cord-291950-9gtsqyfj	60	47	B	B	NNP
cord-291950-9gtsqyfj	60	48	(	(	-LRB-
cord-291950-9gtsqyfj	60	49	Figure	Figure	NNP
cord-291950-9gtsqyfj	60	50	404	404	CD
cord-291950-9gtsqyfj	60	51	.10	.10	CD
cord-291950-9gtsqyfj	60	52	)	)	-RRB-
cord-291950-9gtsqyfj	60	53	.	.	.
cord-291950-9gtsqyfj	61	1	Papain	papain	NN
cord-291950-9gtsqyfj	61	2	-	-	HYPH
cord-291950-9gtsqyfj	61	3	like	like	JJ
cord-291950-9gtsqyfj	61	4	propeptides	propeptide	NNS
cord-291950-9gtsqyfj	61	5	may	may	MD
cord-291950-9gtsqyfj	61	6	be	be	VB
cord-291950-9gtsqyfj	61	7	identified	identify	VBN
cord-291950-9gtsqyfj	61	8	from	from	IN
cord-291950-9gtsqyfj	61	9	the	the	DT
cord-291950-9gtsqyfj	61	10	presence	presence	NN
cord-291950-9gtsqyfj	61	11	of	of	IN
cord-291950-9gtsqyfj	61	12	the	the	DT
cord-291950-9gtsqyfj	61	13	ERFNIN	ERFNIN	NNP
cord-291950-9gtsqyfj	61	14	motif	motif	NN
cord-291950-9gtsqyfj	61	15	,	,	,
cord-291950-9gtsqyfj	61	16	in	in	IN
cord-291950-9gtsqyfj	61	17	which	which	WDT
cord-291950-9gtsqyfj	61	18	some	some	DT
cord-291950-9gtsqyfj	61	19	of	of	IN
cord-291950-9gtsqyfj	61	20	the	the	DT
cord-291950-9gtsqyfj	61	21	following	follow	VBG
cord-291950-9gtsqyfj	61	22	residues	residue	NNS
cord-291950-9gtsqyfj	61	23	(	(	-LRB-
cord-291950-9gtsqyfj	61	24	numbered	number	VBN
cord-291950-9gtsqyfj	61	25	according	accord	VBG
cord-291950-9gtsqyfj	61	26	to	to	IN
cord-291950-9gtsqyfj	61	27	the	the	DT
cord-291950-9gtsqyfj	61	28	papain	papain	NN
cord-291950-9gtsqyfj	61	29	propeptide	propeptide	NN
cord-291950-9gtsqyfj	61	30	)	)	-RRB-
cord-291950-9gtsqyfj	61	31	are	be	VBP
cord-291950-9gtsqyfj	61	32	conserved	conserve	VBN
cord-291950-9gtsqyfj	61	33	:	:	:
cord-291950-9gtsqyfj	61	34	Glu64	Glu64	NNP
cord-291950-9gtsqyfj	61	35	,	,	,
cord-291950-9gtsqyfj	61	36	Arg68	Arg68	NNP
cord-291950-9gtsqyfj	61	37	,	,	,
cord-291950-9gtsqyfj	61	38	Phe72	Phe72	NNP
cord-291950-9gtsqyfj	61	39	,	,	,
cord-291950-9gtsqyfj	61	40	Asn75	Asn75	NNP
cord-291950-9gtsqyfj	61	41	,	,	,
cord-291950-9gtsqyfj	61	42	Asn83	Asn83	NNP
cord-291950-9gtsqyfj	61	43	,	,	,
cord-291950-9gtsqyfj	61	44	Phe96	Phe96	NNP
cord-291950-9gtsqyfj	61	45	,	,	,
cord-291950-9gtsqyfj	61	46	Asp98	Asp98	NNP
cord-291950-9gtsqyfj	61	47	and	and	CC
cord-291950-9gtsqyfj	61	48	Glu103	Glu103	NNP
cord-291950-9gtsqyfj	61	49	.	.	.
cord-291950-9gtsqyfj	62	1	The	the	DT
cord-291950-9gtsqyfj	62	2	papain	papain	NN
cord-291950-9gtsqyfj	62	3	propeptide	propeptide	NN
cord-291950-9gtsqyfj	62	4	is	be	VBZ
cord-291950-9gtsqyfj	62	5	homologous	homologous	JJ
cord-291950-9gtsqyfj	62	6	to	to	IN
cord-291950-9gtsqyfj	62	7	proteins	protein	NNS
cord-291950-9gtsqyfj	62	8	CTLA-2α	ctla-2α	CD
cord-291950-9gtsqyfj	62	9	and	and	CC
cord-291950-9gtsqyfj	62	10	CTLA-2β	CTLA-2β	NNP
cord-291950-9gtsqyfj	62	11	of	of	IN
cord-291950-9gtsqyfj	62	12	activated	activate	VBN
cord-291950-9gtsqyfj	62	13	T	T	NNP
cord-291950-9gtsqyfj	62	14	cells	cell	NNS
cord-291950-9gtsqyfj	62	15	,	,	,
cord-291950-9gtsqyfj	62	16	which	which	WDT
cord-291950-9gtsqyfj	62	17	have	have	VBP
cord-291950-9gtsqyfj	62	18	been	be	VBN
cord-291950-9gtsqyfj	62	19	shown	show	VBN
cord-291950-9gtsqyfj	62	20	to	to	TO
cord-291950-9gtsqyfj	62	21	be	be	VB
cord-291950-9gtsqyfj	62	22	cysteine	cysteine	JJ
cord-291950-9gtsqyfj	62	23	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	62	24	inhibitors	inhibitor	NNS
cord-291950-9gtsqyfj	62	25	[	[	-LRB-
cord-291950-9gtsqyfj	62	26	3	3	CD
cord-291950-9gtsqyfj	62	27	]	]	-RRB-
cord-291950-9gtsqyfj	62	28	.	.	.
cord-291950-9gtsqyfj	63	1	It	-PRON-	PRP
cord-291950-9gtsqyfj	63	2	is	be	VBZ
cord-291950-9gtsqyfj	63	3	notable	notable	JJ
cord-291950-9gtsqyfj	63	4	that	that	IN
cord-291950-9gtsqyfj	63	5	residue	residue	NN
cord-291950-9gtsqyfj	63	6	Pro2	Pro2	NNP
cord-291950-9gtsqyfj	63	7	is	be	VBZ
cord-291950-9gtsqyfj	63	8	often	often	RB
cord-291950-9gtsqyfj	63	9	conserved	conserve	VBN
cord-291950-9gtsqyfj	63	10	in	in	IN
cord-291950-9gtsqyfj	63	11	the	the	DT
cord-291950-9gtsqyfj	63	12	mature	mature	JJ
cord-291950-9gtsqyfj	63	13	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	63	14	of	of	IN
cord-291950-9gtsqyfj	63	15	family	family	NN
cord-291950-9gtsqyfj	63	16	C1	C1	NNP
cord-291950-9gtsqyfj	63	17	(	(	-LRB-
cord-291950-9gtsqyfj	63	18	see	see	VB
cord-291950-9gtsqyfj	63	19	the	the	DT
cord-291950-9gtsqyfj	63	20	alignment	alignment	NN
cord-291950-9gtsqyfj	63	21	in	in	IN
cord-291950-9gtsqyfj	63	22	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	63	23	)	)	-RRB-
cord-291950-9gtsqyfj	63	24	,	,	,
cord-291950-9gtsqyfj	63	25	and	and	CC
cord-291950-9gtsqyfj	63	26	this	this	DT
cord-291950-9gtsqyfj	63	27	may	may	MD
cord-291950-9gtsqyfj	63	28	prevent	prevent	VB
cord-291950-9gtsqyfj	63	29	attack	attack	NN
cord-291950-9gtsqyfj	63	30	by	by	IN
cord-291950-9gtsqyfj	63	31	aminopeptidases	aminopeptidase	NNS
cord-291950-9gtsqyfj	63	32	,	,	,
cord-291950-9gtsqyfj	63	33	since	since	IN
cord-291950-9gtsqyfj	63	34	the	the	DT
cord-291950-9gtsqyfj	63	35	Xaa	Xaa	NNP
cord-291950-9gtsqyfj	63	36	-	-	HYPH
cord-291950-9gtsqyfj	63	37	Pro	pro	JJ
cord-291950-9gtsqyfj	63	38	bond	bond	NN
cord-291950-9gtsqyfj	63	39	is	be	VBZ
cord-291950-9gtsqyfj	63	40	resistant	resistant	JJ
cord-291950-9gtsqyfj	63	41	to	to	IN
cord-291950-9gtsqyfj	63	42	many	many	JJ
cord-291950-9gtsqyfj	63	43	such	such	JJ
cord-291950-9gtsqyfj	63	44	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	63	45	.	.	.
cord-291950-9gtsqyfj	64	1	Most	Most	JJS
cord-291950-9gtsqyfj	64	2	members	member	NNS
cord-291950-9gtsqyfj	64	3	of	of	IN
cord-291950-9gtsqyfj	64	4	subfamily	subfamily	NN
cord-291950-9gtsqyfj	64	5	C1A	c1a	NN
cord-291950-9gtsqyfj	64	6	are	be	VBP
cord-291950-9gtsqyfj	64	7	monomeric	monomeric	JJ
cord-291950-9gtsqyfj	64	8	,	,	,
cord-291950-9gtsqyfj	64	9	but	but	CC
cord-291950-9gtsqyfj	64	10	dipeptidyl	dipeptidyl	JJ
cord-291950-9gtsqyfj	64	11	-	-	HYPH
cord-291950-9gtsqyfj	64	12	peptidase	peptidase	NN
cord-291950-9gtsqyfj	64	13	I	-PRON-	PRP
cord-291950-9gtsqyfj	64	14	is	be	VBZ
cord-291950-9gtsqyfj	64	15	a	a	DT
cord-291950-9gtsqyfj	64	16	homotetramer	homotetramer	NN
cord-291950-9gtsqyfj	64	17	in	in	IN
cord-291950-9gtsqyfj	64	18	which	which	WDT
cord-291950-9gtsqyfj	64	19	each	each	DT
cord-291950-9gtsqyfj	64	20	FIGURE	figure	NN
cord-291950-9gtsqyfj	64	21	404.5	404.5	CD
cord-291950-9gtsqyfj	64	22	Richardson	Richardson	NNP
cord-291950-9gtsqyfj	64	23	diagram	diagram	NN
cord-291950-9gtsqyfj	64	24	of	of	IN
cord-291950-9gtsqyfj	64	25	foot	foot	NN
cord-291950-9gtsqyfj	64	26	-	-	HYPH
cord-291950-9gtsqyfj	64	27	and	and	CC
cord-291950-9gtsqyfj	64	28	-	-	HYPH
cord-291950-9gtsqyfj	64	29	mouth	mouth	NN
cord-291950-9gtsqyfj	64	30	disease	disease	NN
cord-291950-9gtsqyfj	64	31	virus	virus	NN
cord-291950-9gtsqyfj	64	32	L	l	NN
cord-291950-9gtsqyfj	64	33	-	-	HYPH
cord-291950-9gtsqyfj	64	34	peptidase	peptidase	NN
cord-291950-9gtsqyfj	64	35	.	.	.
cord-291950-9gtsqyfj	65	1	The	the	DT
cord-291950-9gtsqyfj	65	2	image	image	NN
cord-291950-9gtsqyfj	65	3	was	be	VBD
cord-291950-9gtsqyfj	65	4	prepared	prepare	VBN
cord-291950-9gtsqyfj	65	5	from	from	IN
cord-291950-9gtsqyfj	65	6	the	the	DT
cord-291950-9gtsqyfj	65	7	Protein	Protein	NNP
cord-291950-9gtsqyfj	65	8	Data	Data	NNP
cord-291950-9gtsqyfj	65	9	Bank	Bank	NNP
cord-291950-9gtsqyfj	65	10	entry	entry	NN
cord-291950-9gtsqyfj	65	11	(	(	-LRB-
cord-291950-9gtsqyfj	65	12	1QMY	1QMY	NNP
cord-291950-9gtsqyfj	65	13	)	)	-RRB-
cord-291950-9gtsqyfj	65	14	as	as	IN
cord-291950-9gtsqyfj	65	15	described	describe	VBN
cord-291950-9gtsqyfj	65	16	in	in	IN
cord-291950-9gtsqyfj	65	17	the	the	DT
cord-291950-9gtsqyfj	65	18	Introduction	introduction	NN
cord-291950-9gtsqyfj	65	19	(	(	-LRB-
cord-291950-9gtsqyfj	65	20	p.	p.	NN
cord-291950-9gtsqyfj	65	21	li	li	NNP
cord-291950-9gtsqyfj	65	22	)	)	-RRB-
cord-291950-9gtsqyfj	65	23	.	.	.
cord-291950-9gtsqyfj	66	1	One	one	CD
cord-291950-9gtsqyfj	66	2	molecule	molecule	NN
cord-291950-9gtsqyfj	66	3	of	of	IN
cord-291950-9gtsqyfj	66	4	the	the	DT
cord-291950-9gtsqyfj	66	5	trimer	trimer	NN
cord-291950-9gtsqyfj	66	6	is	be	VBZ
cord-291950-9gtsqyfj	66	7	shown	show	VBN
cord-291950-9gtsqyfj	66	8	.	.	.
cord-291950-9gtsqyfj	67	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	67	2	residues	residue	NNS
cord-291950-9gtsqyfj	67	3	are	be	VBP
cord-291950-9gtsqyfj	67	4	shown	show	VBN
cord-291950-9gtsqyfj	67	5	in	in	IN
cord-291950-9gtsqyfj	67	6	ball	ball	NN
cord-291950-9gtsqyfj	67	7	-	-	HYPH
cord-291950-9gtsqyfj	67	8	and	and	CC
cord-291950-9gtsqyfj	67	9	-	-	HYPH
cord-291950-9gtsqyfj	67	10	stick	stick	NN
cord-291950-9gtsqyfj	67	11	representation	representation	NN
cord-291950-9gtsqyfj	67	12	:	:	:
cord-291950-9gtsqyfj	67	13	Cys51	Cys51	NNP
cord-291950-9gtsqyfj	67	14	(	(	-LRB-
cord-291950-9gtsqyfj	67	15	engineered	engineer	VBN
cord-291950-9gtsqyfj	67	16	to	to	TO
cord-291950-9gtsqyfj	67	17	be	be	VB
cord-291950-9gtsqyfj	67	18	Ala	Ala	NNP
cord-291950-9gtsqyfj	67	19	)	)	-RRB-
cord-291950-9gtsqyfj	67	20	,	,	,
cord-291950-9gtsqyfj	67	21	His148	His148	NNS
cord-291950-9gtsqyfj	67	22	and	and	CC
cord-291950-9gtsqyfj	67	23	Asp163	Asp163	.
cord-291950-9gtsqyfj	67	24	(	(	-LRB-
cord-291950-9gtsqyfj	67	25	numbering	number	VBG
cord-291950-9gtsqyfj	67	26	as	as	IN
cord-291950-9gtsqyfj	67	27	in	in	IN
cord-291950-9gtsqyfj	67	28	PDB	PDB	NNP
cord-291950-9gtsqyfj	67	29	entry	entry	NN
cord-291950-9gtsqyfj	67	30	)	)	-RRB-
cord-291950-9gtsqyfj	67	31	.	.	.
cord-291950-9gtsqyfj	68	1	The	the	DT
cord-291950-9gtsqyfj	68	2	image	image	NN
cord-291950-9gtsqyfj	68	3	was	be	VBD
cord-291950-9gtsqyfj	68	4	prepared	prepare	VBN
cord-291950-9gtsqyfj	68	5	from	from	IN
cord-291950-9gtsqyfj	68	6	the	the	DT
cord-291950-9gtsqyfj	68	7	Protein	Protein	NNP
cord-291950-9gtsqyfj	68	8	Data	Data	NNP
cord-291950-9gtsqyfj	68	9	Bank	Bank	NNP
cord-291950-9gtsqyfj	68	10	entry	entry	NN
cord-291950-9gtsqyfj	68	11	(	(	-LRB-
cord-291950-9gtsqyfj	68	12	1CV8	1cv8	CD
cord-291950-9gtsqyfj	68	13	)	)	-RRB-
cord-291950-9gtsqyfj	68	14	as	as	IN
cord-291950-9gtsqyfj	68	15	described	describe	VBN
cord-291950-9gtsqyfj	68	16	in	in	IN
cord-291950-9gtsqyfj	68	17	the	the	DT
cord-291950-9gtsqyfj	68	18	Introduction	introduction	NN
cord-291950-9gtsqyfj	68	19	(	(	-LRB-
cord-291950-9gtsqyfj	68	20	p.	p.	NN
cord-291950-9gtsqyfj	68	21	li	li	NNP
cord-291950-9gtsqyfj	68	22	)	)	-RRB-
cord-291950-9gtsqyfj	68	23	.	.	.
cord-291950-9gtsqyfj	69	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	69	2	residues	residue	NNS
cord-291950-9gtsqyfj	69	3	are	be	VBP
cord-291950-9gtsqyfj	69	4	shown	show	VBN
cord-291950-9gtsqyfj	69	5	in	in	IN
cord-291950-9gtsqyfj	69	6	balland	balland	JJ
cord-291950-9gtsqyfj	69	7	-	-	HYPH
cord-291950-9gtsqyfj	69	8	stick	stick	NN
cord-291950-9gtsqyfj	69	9	representation	representation	NN
cord-291950-9gtsqyfj	69	10	:	:	:
cord-291950-9gtsqyfj	69	11	Cys24	Cys24	NNP
cord-291950-9gtsqyfj	69	12	,	,	,
cord-291950-9gtsqyfj	69	13	His120	His120	.
cord-291950-9gtsqyfj	70	1	and	and	CC
cord-291950-9gtsqyfj	70	2	Asn141	Asn141	NFP
cord-291950-9gtsqyfj	70	3	(	(	-LRB-
cord-291950-9gtsqyfj	70	4	numbering	number	VBG
cord-291950-9gtsqyfj	70	5	as	as	IN
cord-291950-9gtsqyfj	70	6	in	in	IN
cord-291950-9gtsqyfj	70	7	PDB	PDB	NNP
cord-291950-9gtsqyfj	70	8	entry	entry	NN
cord-291950-9gtsqyfj	70	9	)	)	-RRB-
cord-291950-9gtsqyfj	70	10	.	.	.
cord-291950-9gtsqyfj	71	1	E-64	E-64	NNP
cord-291950-9gtsqyfj	71	2	is	be	VBZ
cord-291950-9gtsqyfj	71	3	shown	show	VBN
cord-291950-9gtsqyfj	71	4	in	in	IN
cord-291950-9gtsqyfj	71	5	gray	gray	NN
cord-291950-9gtsqyfj	71	6	in	in	IN
cord-291950-9gtsqyfj	71	7	ball	ball	NN
cord-291950-9gtsqyfj	71	8	-	-	HYPH
cord-291950-9gtsqyfj	71	9	and	and	CC
cord-291950-9gtsqyfj	71	10	-	-	HYPH
cord-291950-9gtsqyfj	71	11	stick	stick	NN
cord-291950-9gtsqyfj	71	12	representation	representation	NN
cord-291950-9gtsqyfj	71	13	.	.	.
cord-291950-9gtsqyfj	72	1	monomer	monomer	NN
cord-291950-9gtsqyfj	72	2	consists	consist	VBZ
cord-291950-9gtsqyfj	72	3	of	of	IN
cord-291950-9gtsqyfj	72	4	three	three	CD
cord-291950-9gtsqyfj	72	5	chains	chain	NNS
cord-291950-9gtsqyfj	72	6	as	as	IN
cord-291950-9gtsqyfj	72	7	a	a	DT
cord-291950-9gtsqyfj	72	8	result	result	NN
cord-291950-9gtsqyfj	72	9	of	of	IN
cord-291950-9gtsqyfj	72	10	proteolytic	proteolytic	JJ
cord-291950-9gtsqyfj	72	11	processing	processing	NN
cord-291950-9gtsqyfj	72	12	.	.	.
cord-291950-9gtsqyfj	73	1	Some	some	DT
cord-291950-9gtsqyfj	73	2	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	73	3	of	of	IN
cord-291950-9gtsqyfj	73	4	subfamily	subfamily	NN
cord-291950-9gtsqyfj	73	5	C1A	c1a	NN
cord-291950-9gtsqyfj	73	6	have	have	VBP
cord-291950-9gtsqyfj	73	7	C	c	NN
cord-291950-9gtsqyfj	73	8	-	-	HYPH
cord-291950-9gtsqyfj	73	9	terminal	terminal	NN
cord-291950-9gtsqyfj	73	10	extensions	extension	NNS
cord-291950-9gtsqyfj	73	11	relative	relative	JJ
cord-291950-9gtsqyfj	73	12	to	to	IN
cord-291950-9gtsqyfj	73	13	papain	papain	NN
cord-291950-9gtsqyfj	73	14	.	.	.
cord-291950-9gtsqyfj	74	1	Among	among	IN
cord-291950-9gtsqyfj	74	2	the	the	DT
cord-291950-9gtsqyfj	74	3	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	74	4	from	from	IN
cord-291950-9gtsqyfj	74	5	plants	plant	NNS
cord-291950-9gtsqyfj	74	6	,	,	,
cord-291950-9gtsqyfj	74	7	the	the	DT
cord-291950-9gtsqyfj	74	8	extensions	extension	NNS
cord-291950-9gtsqyfj	74	9	at	at	IN
cord-291950-9gtsqyfj	74	10	the	the	DT
cord-291950-9gtsqyfj	74	11	C	C	NNP
cord-291950-9gtsqyfj	74	12	-	-	HYPH
cord-291950-9gtsqyfj	74	13	terminus	terminus	NN
cord-291950-9gtsqyfj	74	14	of	of	IN
cord-291950-9gtsqyfj	74	15	oryzains	oryzains	NNP
cord-291950-9gtsqyfj	74	16	α	α	NNP
cord-291950-9gtsqyfj	74	17	and	and	CC
cord-291950-9gtsqyfj	74	18	β	β	NN
cord-291950-9gtsqyfj	74	19	,	,	,
cord-291950-9gtsqyfj	74	20	and	and	CC
cord-291950-9gtsqyfj	74	21	cysteine	cysteine	NN
cord-291950-9gtsqyfj	74	22	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	74	23	from	from	IN
cord-291950-9gtsqyfj	74	24	tomato	tomato	NN
cord-291950-9gtsqyfj	74	25	(	(	-LRB-
cord-291950-9gtsqyfj	74	26	UniProt	UniProt	NNP
cord-291950-9gtsqyfj	74	27	P20721	P20721	NNP
cord-291950-9gtsqyfj	74	28	)	)	-RRB-
cord-291950-9gtsqyfj	74	29	,	,	,
cord-291950-9gtsqyfj	74	30	Arabidopsis	Arabidopsis	NNP
cord-291950-9gtsqyfj	74	31	thaliana	thaliana	NN
cord-291950-9gtsqyfj	74	32	(	(	-LRB-
cord-291950-9gtsqyfj	74	33	UniProt	UniProt	NNP
cord-291950-9gtsqyfj	74	34	:	:	:
cord-291950-9gtsqyfj	74	35	P43297	P43297	NNP
cord-291950-9gtsqyfj	74	36	)	)	-RRB-
cord-291950-9gtsqyfj	74	37	,	,	,
cord-291950-9gtsqyfj	74	38	Douglas	Douglas	NNP
cord-291950-9gtsqyfj	74	39	fir	fir	NN
cord-291950-9gtsqyfj	74	40	(	(	-LRB-
cord-291950-9gtsqyfj	74	41	UniProt	UniProt	NNP
cord-291950-9gtsqyfj	74	42	:	:	:
cord-291950-9gtsqyfj	74	43	Q40922	Q40922	NNP
cord-291950-9gtsqyfj	74	44	)	)	-RRB-
cord-291950-9gtsqyfj	74	45	,	,	,
cord-291950-9gtsqyfj	74	46	carnation	carnation	NN
cord-291950-9gtsqyfj	74	47	(	(	-LRB-
cord-291950-9gtsqyfj	74	48	UniProt	UniProt	NNP
cord-291950-9gtsqyfj	74	49	:	:	:
cord-291950-9gtsqyfj	74	50	Q43423	Q43423	NNP
cord-291950-9gtsqyfj	74	51	)	)	-RRB-
cord-291950-9gtsqyfj	74	52	and	and	CC
cord-291950-9gtsqyfj	74	53	pea	pea	NN
cord-291950-9gtsqyfj	74	54	(	(	-LRB-
cord-291950-9gtsqyfj	74	55	UniProt	UniProt	NNP
cord-291950-9gtsqyfj	74	56	:	:	:
cord-291950-9gtsqyfj	74	57	Q41064	Q41064	NNP
cord-291950-9gtsqyfj	74	58	)	)	-RRB-
cord-291950-9gtsqyfj	74	59	are	be	VBP
cord-291950-9gtsqyfj	74	60	homologous	homologous	JJ
cord-291950-9gtsqyfj	74	61	.	.	.
cord-291950-9gtsqyfj	75	1	The	the	DT
cord-291950-9gtsqyfj	75	2	C	c	NN
cord-291950-9gtsqyfj	75	3	-	-	HYPH
cord-291950-9gtsqyfj	75	4	terminal	terminal	NN
cord-291950-9gtsqyfj	75	5	extensions	extension	NNS
cord-291950-9gtsqyfj	75	6	found	find	VBN
cord-291950-9gtsqyfj	75	7	in	in	IN
cord-291950-9gtsqyfj	75	8	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	75	9	from	from	IN
cord-291950-9gtsqyfj	75	10	Trypanosoma	Trypanosoma	NNP
cord-291950-9gtsqyfj	75	11	and	and	CC
cord-291950-9gtsqyfj	75	12	Leishmania	Leishmania	NNP
cord-291950-9gtsqyfj	75	13	are	be	VBP
cord-291950-9gtsqyfj	75	14	unique	unique	JJ
cord-291950-9gtsqyfj	75	15	in	in	IN
cord-291950-9gtsqyfj	75	16	the	the	DT
cord-291950-9gtsqyfj	75	17	family	family	NN
cord-291950-9gtsqyfj	75	18	.	.	.
cord-291950-9gtsqyfj	76	1	Inserts	insert	NNS
cord-291950-9gtsqyfj	76	2	relative	relative	JJ
cord-291950-9gtsqyfj	76	3	to	to	IN
cord-291950-9gtsqyfj	76	4	papain	papain	NN
cord-291950-9gtsqyfj	76	5	occur	occur	VBP
cord-291950-9gtsqyfj	76	6	within	within	IN
cord-291950-9gtsqyfj	76	7	the	the	DT
cord-291950-9gtsqyfj	76	8	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	76	9	domain	domain	NN
cord-291950-9gtsqyfj	76	10	in	in	IN
cord-291950-9gtsqyfj	76	11	other	other	JJ
cord-291950-9gtsqyfj	76	12	members	member	NNS
cord-291950-9gtsqyfj	76	13	of	of	IN
cord-291950-9gtsqyfj	76	14	the	the	DT
cord-291950-9gtsqyfj	76	15	family	family	NN
cord-291950-9gtsqyfj	76	16	.	.	.
cord-291950-9gtsqyfj	77	1	In	in	IN
cord-291950-9gtsqyfj	77	2	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	77	3	B	b	NN
cord-291950-9gtsqyfj	77	4	,	,	,
cord-291950-9gtsqyfj	77	5	the	the	DT
cord-291950-9gtsqyfj	77	6	'	'	``
cord-291950-9gtsqyfj	77	7	occluding	occlude	VBG
cord-291950-9gtsqyfj	77	8	loop	loop	NN
cord-291950-9gtsqyfj	77	9	'	'	''
cord-291950-9gtsqyfj	77	10	that	that	WDT
cord-291950-9gtsqyfj	77	11	carries	carry	VBZ
cord-291950-9gtsqyfj	77	12	the	the	DT
cord-291950-9gtsqyfj	77	13	histidine	histidine	NN
cord-291950-9gtsqyfj	77	14	residues	residue	NNS
cord-291950-9gtsqyfj	77	15	important	important	JJ
cord-291950-9gtsqyfj	77	16	for	for	IN
cord-291950-9gtsqyfj	77	17	peptidyl	peptidyl	JJ
cord-291950-9gtsqyfj	77	18	-	-	HYPH
cord-291950-9gtsqyfj	77	19	dipeptidase	dipeptidase	NN
cord-291950-9gtsqyfj	77	20	activity	activity	NN
cord-291950-9gtsqyfj	77	21	is	be	VBZ
cord-291950-9gtsqyfj	77	22	inserted	insert	VBN
cord-291950-9gtsqyfj	77	23	between	between	IN
cord-291950-9gtsqyfj	77	24	the	the	DT
cord-291950-9gtsqyfj	77	25	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	77	26	Cys	Cys	NNP
cord-291950-9gtsqyfj	77	27	and	and	CC
cord-291950-9gtsqyfj	77	28	His	-PRON-	PRP$
cord-291950-9gtsqyfj	77	29	residues	residue	NNS
cord-291950-9gtsqyfj	77	30	.	.	.
cord-291950-9gtsqyfj	78	1	This	this	DT
cord-291950-9gtsqyfj	78	2	loop	loop	NN
cord-291950-9gtsqyfj	78	3	is	be	VBZ
cord-291950-9gtsqyfj	78	4	not	not	RB
cord-291950-9gtsqyfj	78	5	present	present	JJ
cord-291950-9gtsqyfj	78	6	in	in	IN
cord-291950-9gtsqyfj	78	7	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	78	8	from	from	IN
cord-291950-9gtsqyfj	78	9	Giardia	Giardia	NNP
cord-291950-9gtsqyfj	78	10	[	[	-LRB-
cord-291950-9gtsqyfj	78	11	4	4	LS
cord-291950-9gtsqyfj	78	12	]	]	-RRB-
cord-291950-9gtsqyfj	78	13	that	that	WDT
cord-291950-9gtsqyfj	78	14	are	be	VBP
cord-291950-9gtsqyfj	78	15	the	the	DT
cord-291950-9gtsqyfj	78	16	most	most	RBS
cord-291950-9gtsqyfj	78	17	divergent	divergent	JJ
cord-291950-9gtsqyfj	78	18	of	of	IN
cord-291950-9gtsqyfj	78	19	the	the	DT
cord-291950-9gtsqyfj	78	20	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	78	21	B	b	NN
cord-291950-9gtsqyfj	78	22	-	-	HYPH
cord-291950-9gtsqyfj	78	23	like	like	JJ
cord-291950-9gtsqyfj	78	24	proteins	protein	NNS
cord-291950-9gtsqyfj	78	25	and	and	CC
cord-291950-9gtsqyfj	78	26	probably	probably	RB
cord-291950-9gtsqyfj	78	27	represent	represent	VBP
cord-291950-9gtsqyfj	78	28	the	the	DT
cord-291950-9gtsqyfj	78	29	primitive	primitive	JJ
cord-291950-9gtsqyfj	78	30	state	state	NN
cord-291950-9gtsqyfj	78	31	.	.	.
cord-291950-9gtsqyfj	79	1	Some	some	DT
cord-291950-9gtsqyfj	79	2	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	79	3	from	from	IN
cord-291950-9gtsqyfj	79	4	Dictyostelium	Dictyostelium	NNP
cord-291950-9gtsqyfj	79	5	possess	possess	VBP
cord-291950-9gtsqyfj	79	6	glycine	glycine	NN
cord-291950-9gtsqyfj	79	7	-	-	HYPH
cord-291950-9gtsqyfj	79	8	and	and	CC
cord-291950-9gtsqyfj	79	9	serine	serine	NN
cord-291950-9gtsqyfj	79	10	-	-	HYPH
cord-291950-9gtsqyfj	79	11	rich	rich	JJ
cord-291950-9gtsqyfj	79	12	inserts	insert	NNS
cord-291950-9gtsqyfj	79	13	between	between	IN
cord-291950-9gtsqyfj	79	14	the	the	DT
cord-291950-9gtsqyfj	79	15	active	active	JJ
cord-291950-9gtsqyfj	79	16	site	site	NN
cord-291950-9gtsqyfj	79	17	His	-PRON-	PRP$
cord-291950-9gtsqyfj	79	18	and	and	CC
cord-291950-9gtsqyfj	79	19	Asn	Asn	NNP
cord-291950-9gtsqyfj	79	20	.	.	.
cord-291950-9gtsqyfj	80	1	The	the	DT
cord-291950-9gtsqyfj	80	2	specificity	specificity	NN
cord-291950-9gtsqyfj	80	3	subsite	subsite	NN
cord-291950-9gtsqyfj	80	4	that	that	WDT
cord-291950-9gtsqyfj	80	5	is	be	VBZ
cord-291950-9gtsqyfj	80	6	dominant	dominant	JJ
cord-291950-9gtsqyfj	80	7	in	in	IN
cord-291950-9gtsqyfj	80	8	most	most	JJS
cord-291950-9gtsqyfj	80	9	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	80	10	of	of	IN
cord-291950-9gtsqyfj	80	11	subfamily	subfamily	NN
cord-291950-9gtsqyfj	80	12	C1A	c1a	NN
cord-291950-9gtsqyfj	80	13	is	be	VBZ
cord-291950-9gtsqyfj	80	14	S2	S2	NNP
cord-291950-9gtsqyfj	80	15	,	,	,
cord-291950-9gtsqyfj	80	16	which	which	WDT
cord-291950-9gtsqyfj	80	17	commonly	commonly	RB
cord-291950-9gtsqyfj	80	18	displays	display	VBZ
cord-291950-9gtsqyfj	80	19	a	a	DT
cord-291950-9gtsqyfj	80	20	preference	preference	NN
cord-291950-9gtsqyfj	80	21	for	for	IN
cord-291950-9gtsqyfj	80	22	occupation	occupation	NN
cord-291950-9gtsqyfj	80	23	by	by	IN
cord-291950-9gtsqyfj	80	24	a	a	DT
cord-291950-9gtsqyfj	80	25	bulky	bulky	JJ
cord-291950-9gtsqyfj	80	26	hydrophobic	hydrophobic	JJ
cord-291950-9gtsqyfj	80	27	side	side	NN
cord-291950-9gtsqyfj	80	28	chain	chain	NN
cord-291950-9gtsqyfj	80	29	,	,	,
cord-291950-9gtsqyfj	80	30	and	and	CC
cord-291950-9gtsqyfj	80	31	not	not	RB
cord-291950-9gtsqyfj	80	32	a	a	DT
cord-291950-9gtsqyfj	80	33	charged	charge	VBN
cord-291950-9gtsqyfj	80	34	one	one	CD
cord-291950-9gtsqyfj	80	35	.	.	.
cord-291950-9gtsqyfj	81	1	Unusually	unusually	RB
cord-291950-9gtsqyfj	81	2	,	,	,
cord-291950-9gtsqyfj	81	3	the	the	DT
cord-291950-9gtsqyfj	81	4	S2	s2	NN
cord-291950-9gtsqyfj	81	5	subsite	subsite	NN
cord-291950-9gtsqyfj	81	6	of	of	IN
cord-291950-9gtsqyfj	81	7	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	81	8	B	B	NNP
cord-291950-9gtsqyfj	81	9	readily	readily	RB
cord-291950-9gtsqyfj	81	10	accepts	accept	VBZ
cord-291950-9gtsqyfj	81	11	Arg	arg	NN
cord-291950-9gtsqyfj	81	12	,	,	,
cord-291950-9gtsqyfj	81	13	however	however	RB
cord-291950-9gtsqyfj	81	14	,	,	,
cord-291950-9gtsqyfj	81	15	so	so	IN
cord-291950-9gtsqyfj	81	16	that	that	IN
cord-291950-9gtsqyfj	81	17	Z	z	NN
cord-291950-9gtsqyfj	81	18	-	-	HYPH
cord-291950-9gtsqyfj	81	19	Arg	arg	NN
cord-291950-9gtsqyfj	81	20	-	-	HYPH
cord-291950-9gtsqyfj	81	21	ArgkNHMec	ArgkNHMec	NNP
cord-291950-9gtsqyfj	81	22	is	be	VBZ
cord-291950-9gtsqyfj	81	23	a	a	DT
cord-291950-9gtsqyfj	81	24	good	good	JJ
cord-291950-9gtsqyfj	81	25	selective	selective	JJ
cord-291950-9gtsqyfj	81	26	substrate	substrate	NN
cord-291950-9gtsqyfj	81	27	for	for	IN
cord-291950-9gtsqyfj	81	28	the	the	DT
cord-291950-9gtsqyfj	81	29	enzyme	enzyme	NN
cord-291950-9gtsqyfj	81	30	.	.	.
cord-291950-9gtsqyfj	82	1	This	this	DT
cord-291950-9gtsqyfj	82	2	distinctive	distinctive	JJ
cord-291950-9gtsqyfj	82	3	specificity	specificity	NN
cord-291950-9gtsqyfj	82	4	of	of	IN
cord-291950-9gtsqyfj	82	5	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	82	6	B	b	NN
cord-291950-9gtsqyfj	82	7	can	can	MD
cord-291950-9gtsqyfj	82	8	be	be	VB
cord-291950-9gtsqyfj	82	9	explained	explain	VBN
cord-291950-9gtsqyfj	82	10	by	by	IN
cord-291950-9gtsqyfj	82	11	the	the	DT
cord-291950-9gtsqyfj	82	12	residue	residue	NN
cord-291950-9gtsqyfj	82	13	lying	lie	VBG
cord-291950-9gtsqyfj	82	14	at	at	IN
cord-291950-9gtsqyfj	82	15	the	the	DT
cord-291950-9gtsqyfj	82	16	bottom	bottom	NN
cord-291950-9gtsqyfj	82	17	of	of	IN
cord-291950-9gtsqyfj	82	18	the	the	DT
cord-291950-9gtsqyfj	82	19	S2	S2	NNP
cord-291950-9gtsqyfj	82	20	pocket	pocket	NN
cord-291950-9gtsqyfj	82	21	,	,	,
cord-291950-9gtsqyfj	82	22	which	which	WDT
cord-291950-9gtsqyfj	82	23	in	in	IN
cord-291950-9gtsqyfj	82	24	papain	papain	NN
cord-291950-9gtsqyfj	82	25	is	be	VBZ
cord-291950-9gtsqyfj	82	26	Ser338	ser338	CD
cord-291950-9gtsqyfj	82	27	,	,	,
cord-291950-9gtsqyfj	82	28	but	but	CC
cord-291950-9gtsqyfj	82	29	in	in	IN
cord-291950-9gtsqyfj	82	30	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	82	31	B	b	NN
cord-291950-9gtsqyfj	82	32	is	be	VBZ
cord-291950-9gtsqyfj	82	33	Glu	Glu	NNP
cord-291950-9gtsqyfj	82	34	(	(	-LRB-
cord-291950-9gtsqyfj	82	35	numbering	number	VBG
cord-291950-9gtsqyfj	82	36	as	as	IN
cord-291950-9gtsqyfj	82	37	in	in	IN
cord-291950-9gtsqyfj	82	38	the	the	DT
cord-291950-9gtsqyfj	82	39	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	82	40	C1	C1	NNP
cord-291950-9gtsqyfj	82	41	alignment	alignment	NN
cord-291950-9gtsqyfj	82	42	)	)	-RRB-
cord-291950-9gtsqyfj	82	43	.	.	.
cord-291950-9gtsqyfj	83	1	Glu338	Glu338	NNS
cord-291950-9gtsqyfj	83	2	also	also	RB
cord-291950-9gtsqyfj	83	3	occurs	occur	VBZ
cord-291950-9gtsqyfj	83	4	in	in	IN
cord-291950-9gtsqyfj	83	5	cysteine	cysteine	JJ
cord-291950-9gtsqyfj	83	6	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	83	7	from	from	IN
cord-291950-9gtsqyfj	83	8	Figure	figure	NN
cord-291950-9gtsqyfj	83	9	404	404	CD
cord-291950-9gtsqyfj	83	10	.4	.4	NFP
cord-291950-9gtsqyfj	83	11	)	)	-RRB-
cord-291950-9gtsqyfj	83	12	contains	contain	VBZ
cord-291950-9gtsqyfj	83	13	several	several	JJ
cord-291950-9gtsqyfj	83	14	soluble	soluble	JJ
cord-291950-9gtsqyfj	83	15	,	,	,
cord-291950-9gtsqyfj	83	16	intracellular	intracellular	JJ
cord-291950-9gtsqyfj	83	17	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	83	18	.	.	.
cord-291950-9gtsqyfj	84	1	These	these	DT
cord-291950-9gtsqyfj	84	2	are	be	VBP
cord-291950-9gtsqyfj	84	3	aminopeptidases	aminopeptidase	NNS
cord-291950-9gtsqyfj	84	4	that	that	WDT
cord-291950-9gtsqyfj	84	5	commonly	commonly	RB
cord-291950-9gtsqyfj	84	6	show	show	VBP
cord-291950-9gtsqyfj	84	7	selectivity	selectivity	NN
cord-291950-9gtsqyfj	84	8	for	for	IN
cord-291950-9gtsqyfj	84	9	release	release	NN
cord-291950-9gtsqyfj	84	10	of	of	IN
cord-291950-9gtsqyfj	84	11	N	n	CD
cord-291950-9gtsqyfj	84	12	-	-	HYPH
cord-291950-9gtsqyfj	84	13	terminal	terminal	NN
cord-291950-9gtsqyfj	84	14	Arg	arg	NN
cord-291950-9gtsqyfj	84	15	residues	residue	NNS
cord-291950-9gtsqyfj	84	16	,	,	,
cord-291950-9gtsqyfj	84	17	and	and	CC
cord-291950-9gtsqyfj	84	18	include	include	VBP
cord-291950-9gtsqyfj	84	19	aminopeptidase	aminopeptidase	NN
cord-291950-9gtsqyfj	84	20	C	c	NN
cord-291950-9gtsqyfj	84	21	(	(	-LRB-
cord-291950-9gtsqyfj	84	22	PepC	PepC	NNP
cord-291950-9gtsqyfj	84	23	)	)	-RRB-
cord-291950-9gtsqyfj	84	24	from	from	IN
cord-291950-9gtsqyfj	84	25	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	84	26	(	(	-LRB-
cord-291950-9gtsqyfj	84	27	Chapter	chapter	NN
cord-291950-9gtsqyfj	84	28	451	451	CD
cord-291950-9gtsqyfj	84	29	)	)	-RRB-
cord-291950-9gtsqyfj	84	30	,	,	,
cord-291950-9gtsqyfj	84	31	and	and	CC
cord-291950-9gtsqyfj	84	32	bleomycin	bleomycin	NN
cord-291950-9gtsqyfj	84	33	hydrolase	hydrolase	NNP
cord-291950-9gtsqyfj	84	34	(	(	-LRB-
cord-291950-9gtsqyfj	84	35	Chapter	chapter	NN
cord-291950-9gtsqyfj	84	36	449	449	CD
cord-291950-9gtsqyfj	84	37	)	)	-RRB-
cord-291950-9gtsqyfj	84	38	from	from	IN
cord-291950-9gtsqyfj	84	39	eukaryotes	eukaryote	NNS
cord-291950-9gtsqyfj	84	40	.	.	.
cord-291950-9gtsqyfj	85	1	Note	note	VB
cord-291950-9gtsqyfj	85	2	that	that	DT
cord-291950-9gtsqyfj	86	1	no	no	DT
cord-291950-9gtsqyfj	86	2	bleomycin	bleomycin	RB
cord-291950-9gtsqyfj	86	3	hydrolase	hydrolase	NN
cord-291950-9gtsqyfj	86	4	homolog	homolog	NN
cord-291950-9gtsqyfj	86	5	is	be	VBZ
cord-291950-9gtsqyfj	86	6	The	the	DT
cord-291950-9gtsqyfj	86	7	aminopeptidase	aminopeptidase	NN
cord-291950-9gtsqyfj	86	8	C	c	NN
cord-291950-9gtsqyfj	86	9	-	-	HYPH
cord-291950-9gtsqyfj	86	10	like	like	JJ
cord-291950-9gtsqyfj	86	11	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	86	12	are	be	VBP
cord-291950-9gtsqyfj	86	13	oligomeric	oligomeric	JJ
cord-291950-9gtsqyfj	86	14	.	.	.
cord-291950-9gtsqyfj	87	1	The	the	DT
cord-291950-9gtsqyfj	87	2	yeast	yeast	NN
cord-291950-9gtsqyfj	87	3	bleomycin	bleomycin	VBZ
cord-291950-9gtsqyfj	87	4	hydrolase	hydrolase	NN
cord-291950-9gtsqyfj	87	5	is	be	VBZ
cord-291950-9gtsqyfj	87	6	probably	probably	RB
cord-291950-9gtsqyfj	87	7	representative	representative	JJ
cord-291950-9gtsqyfj	87	8	,	,	,
cord-291950-9gtsqyfj	87	9	and	and	CC
cord-291950-9gtsqyfj	87	10	is	be	VBZ
cord-291950-9gtsqyfj	87	11	a	a	DT
cord-291950-9gtsqyfj	87	12	homohexamer	homohexamer	NN
cord-291950-9gtsqyfj	87	13	,	,	,
cord-291950-9gtsqyfj	87	14	with	with	IN
cord-291950-9gtsqyfj	87	15	the	the	DT
cord-291950-9gtsqyfj	87	16	active	active	JJ
cord-291950-9gtsqyfj	87	17	sites	site	NNS
cord-291950-9gtsqyfj	87	18	arranged	arrange	VBN
cord-291950-9gtsqyfj	87	19	on	on	IN
cord-291950-9gtsqyfj	87	20	the	the	DT
cord-291950-9gtsqyfj	87	21	inner	inner	JJ
cord-291950-9gtsqyfj	87	22	face	face	NN
cord-291950-9gtsqyfj	87	23	of	of	IN
cord-291950-9gtsqyfj	87	24	the	the	DT
cord-291950-9gtsqyfj	87	25	central	central	JJ
cord-291950-9gtsqyfj	87	26	channel	channel	NN
cord-291950-9gtsqyfj	87	27	,	,	,
cord-291950-9gtsqyfj	87	28	in	in	IN
cord-291950-9gtsqyfj	87	29	an	an	DT
cord-291950-9gtsqyfj	87	30	arrangement	arrangement	NN
cord-291950-9gtsqyfj	87	31	reminiscent	reminiscent	JJ
cord-291950-9gtsqyfj	87	32	of	of	IN
cord-291950-9gtsqyfj	87	33	that	that	DT
cord-291950-9gtsqyfj	87	34	in	in	IN
cord-291950-9gtsqyfj	87	35	the	the	DT
cord-291950-9gtsqyfj	87	36	proteasome	proteasome	NN
cord-291950-9gtsqyfj	87	37	.	.	.
cord-291950-9gtsqyfj	88	1	This	this	DT
cord-291950-9gtsqyfj	88	2	arrangement	arrangement	NN
cord-291950-9gtsqyfj	88	3	evidently	evidently	RB
cord-291950-9gtsqyfj	88	4	allows	allow	VBZ
cord-291950-9gtsqyfj	88	5	only	only	RB
cord-291950-9gtsqyfj	88	6	small	small	JJ
cord-291950-9gtsqyfj	88	7	molecules	molecule	NNS
cord-291950-9gtsqyfj	88	8	to	to	TO
cord-291950-9gtsqyfj	88	9	interact	interact	VB
cord-291950-9gtsqyfj	88	10	with	with	IN
cord-291950-9gtsqyfj	88	11	the	the	DT
cord-291950-9gtsqyfj	88	12	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	88	13	site	site	NN
cord-291950-9gtsqyfj	88	14	.	.	.
cord-291950-9gtsqyfj	89	1	Unlike	unlike	IN
cord-291950-9gtsqyfj	89	2	papain	papain	NN
cord-291950-9gtsqyfj	89	3	and	and	CC
cord-291950-9gtsqyfj	89	4	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	89	5	B	b	NN
cord-291950-9gtsqyfj	89	6	,	,	,
cord-291950-9gtsqyfj	89	7	the	the	DT
cord-291950-9gtsqyfj	89	8	aminopeptidases	aminopeptidase	NNS
cord-291950-9gtsqyfj	89	9	of	of	IN
cord-291950-9gtsqyfj	89	10	family	family	NN
cord-291950-9gtsqyfj	89	11	C1B	c1b	NN
cord-291950-9gtsqyfj	89	12	do	do	VBP
cord-291950-9gtsqyfj	89	13	not	not	RB
cord-291950-9gtsqyfj	89	14	contain	contain	VB
cord-291950-9gtsqyfj	89	15	disulfide	disulfide	JJ
cord-291950-9gtsqyfj	89	16	bonds	bond	NNS
cord-291950-9gtsqyfj	89	17	and	and	CC
cord-291950-9gtsqyfj	89	18	are	be	VBP
cord-291950-9gtsqyfj	89	19	synthesized	synthesize	VBN
cord-291950-9gtsqyfj	89	20	without	without	IN
cord-291950-9gtsqyfj	89	21	propeptides	propeptide	NNS
cord-291950-9gtsqyfj	89	22	.	.	.
cord-291950-9gtsqyfj	90	1	As	as	IN
cord-291950-9gtsqyfj	90	2	is	be	VBZ
cord-291950-9gtsqyfj	90	3	discussed	discuss	VBN
cord-291950-9gtsqyfj	90	4	in	in	IN
cord-291950-9gtsqyfj	90	5	Chapter	chapter	NN
cord-291950-9gtsqyfj	90	6	449	449	CD
cord-291950-9gtsqyfj	90	7	,	,	,
cord-291950-9gtsqyfj	90	8	the	the	DT
cord-291950-9gtsqyfj	90	9	mature	mature	JJ
cord-291950-9gtsqyfj	90	10	bleomycin	bleomycin	NN
cord-291950-9gtsqyfj	90	11	hydrolase	hydrolase	NNP
cord-291950-9gtsqyfj	90	12	subunit	subunit	NN
cord-291950-9gtsqyfj	90	13	consists	consist	VBZ
cord-291950-9gtsqyfj	90	14	of	of	IN
cord-291950-9gtsqyfj	90	15	three	three	CD
cord-291950-9gtsqyfj	90	16	domains	domain	NNS
cord-291950-9gtsqyfj	90	17	,	,	,
cord-291950-9gtsqyfj	90	18	the	the	DT
cord-291950-9gtsqyfj	90	19	peptidase	peptidase	NN
cord-291950-9gtsqyfj	90	20	domain	domain	NN
cord-291950-9gtsqyfj	90	21	,	,	,
cord-291950-9gtsqyfj	90	22	an	an	DT
cord-291950-9gtsqyfj	90	23	oligomerization	oligomerization	NN
cord-291950-9gtsqyfj	90	24	(	(	-LRB-
cord-291950-9gtsqyfj	90	25	or	or	CC
cord-291950-9gtsqyfj	90	26	'	'	``
cord-291950-9gtsqyfj	90	27	hook	hook	NN
cord-291950-9gtsqyfj	90	28	'	'	''
cord-291950-9gtsqyfj	90	29	)	)	-RRB-
cord-291950-9gtsqyfj	90	30	domain	domain	NN
cord-291950-9gtsqyfj	90	31	,	,	,
cord-291950-9gtsqyfj	90	32	and	and	CC
cord-291950-9gtsqyfj	90	33	a	a	DT
cord-291950-9gtsqyfj	90	34	helical	helical	JJ
cord-291950-9gtsqyfj	90	35	domain	domain	NN
cord-291950-9gtsqyfj	90	36	.	.	.
cord-291950-9gtsqyfj	91	1	Half	half	NN
cord-291950-9gtsqyfj	91	2	of	of	IN
cord-291950-9gtsqyfj	91	3	the	the	DT
cord-291950-9gtsqyfj	91	4	hook	hook	NN
cord-291950-9gtsqyfj	91	5	domain	domain	NN
cord-291950-9gtsqyfj	91	6	is	be	VBZ
cord-291950-9gtsqyfj	91	7	N	n	CD
cord-291950-9gtsqyfj	91	8	-	-	NN
cord-291950-9gtsqyfj	91	9	terminal	terminal	NN
cord-291950-9gtsqyfj	91	10	to	to	IN
cord-291950-9gtsqyfj	91	11	the	the	DT
cord-291950-9gtsqyfj	91	12	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	91	13	domain	domain	NN
cord-291950-9gtsqyfj	91	14	,	,	,
cord-291950-9gtsqyfj	91	15	but	but	CC
cord-291950-9gtsqyfj	91	16	the	the	DT
cord-291950-9gtsqyfj	91	17	other	other	JJ
cord-291950-9gtsqyfj	91	18	half	half	NN
cord-291950-9gtsqyfj	91	19	is	be	VBZ
cord-291950-9gtsqyfj	91	20	an	an	DT
cord-291950-9gtsqyfj	91	21	insert	insert	NN
cord-291950-9gtsqyfj	91	22	(	(	-LRB-
cord-291950-9gtsqyfj	91	23	relative	relative	JJ
cord-291950-9gtsqyfj	91	24	to	to	IN
cord-291950-9gtsqyfj	91	25	papain	papain	NN
cord-291950-9gtsqyfj	91	26	)	)	-RRB-
cord-291950-9gtsqyfj	91	27	preceding	precede	VBG
cord-291950-9gtsqyfj	91	28	the	the	DT
cord-291950-9gtsqyfj	91	29	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	91	30	His	His	NNP
cord-291950-9gtsqyfj	91	31	.	.	.
cord-291950-9gtsqyfj	92	1	The	the	DT
cord-291950-9gtsqyfj	92	2	helical	helical	JJ
cord-291950-9gtsqyfj	92	3	domain	domain	NN
cord-291950-9gtsqyfj	92	4	corresponds	correspond	VBZ
cord-291950-9gtsqyfj	92	5	to	to	IN
cord-291950-9gtsqyfj	92	6	two	two	CD
cord-291950-9gtsqyfj	92	7	inserts	insert	NNS
cord-291950-9gtsqyfj	92	8	in	in	IN
cord-291950-9gtsqyfj	92	9	the	the	DT
cord-291950-9gtsqyfj	92	10	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	92	11	domain	domain	NN
cord-291950-9gtsqyfj	92	12	with	with	IN
cord-291950-9gtsqyfj	92	13	respect	respect	NN
cord-291950-9gtsqyfj	92	14	to	to	IN
cord-291950-9gtsqyfj	92	15	papain	papain	NN
cord-291950-9gtsqyfj	92	16	.	.	.
cord-291950-9gtsqyfj	93	1	Figure	figure	NN
cord-291950-9gtsqyfj	93	2	404	404	CD
cord-291950-9gtsqyfj	93	3	.11	.11	NFP
cord-291950-9gtsqyfj	93	4	shows	show	VBZ
cord-291950-9gtsqyfj	93	5	the	the	DT
cord-291950-9gtsqyfj	93	6	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	93	7	structure	structure	NN
cord-291950-9gtsqyfj	93	8	of	of	IN
cord-291950-9gtsqyfj	93	9	the	the	DT
cord-291950-9gtsqyfj	93	10	yeast	yeast	NN
cord-291950-9gtsqyfj	93	11	bleomycin	bleomycin	NN
cord-291950-9gtsqyfj	93	12	hydrolase	hydrolase	NNP
cord-291950-9gtsqyfj	93	13	subunit	subunit	NN
cord-291950-9gtsqyfj	93	14	.	.	.
cord-291950-9gtsqyfj	94	1	There	there	EX
cord-291950-9gtsqyfj	94	2	are	be	VBP
cord-291950-9gtsqyfj	94	3	a	a	DT
cord-291950-9gtsqyfj	94	4	number	number	NN
cord-291950-9gtsqyfj	94	5	of	of	IN
cord-291950-9gtsqyfj	94	6	proteins	protein	NNS
cord-291950-9gtsqyfj	94	7	homologous	homologous	JJ
cord-291950-9gtsqyfj	94	8	to	to	IN
cord-291950-9gtsqyfj	94	9	papain	papain	NN
cord-291950-9gtsqyfj	94	10	that	that	WDT
cord-291950-9gtsqyfj	94	11	lack	lack	VBP
cord-291950-9gtsqyfj	94	12	peptidase	peptidase	NN
cord-291950-9gtsqyfj	94	13	activity	activity	NN
cord-291950-9gtsqyfj	94	14	because	because	IN
cord-291950-9gtsqyfj	94	15	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	94	16	residues	residue	NNS
cord-291950-9gtsqyfj	94	17	have	have	VBP
cord-291950-9gtsqyfj	94	18	been	be	VBN
cord-291950-9gtsqyfj	94	19	replaced	replace	VBN
cord-291950-9gtsqyfj	94	20	.	.	.
cord-291950-9gtsqyfj	95	1	These	these	DT
cord-291950-9gtsqyfj	95	2	include	include	VBP
cord-291950-9gtsqyfj	95	3	an	an	DT
cord-291950-9gtsqyfj	95	4	oil	oil	NN
cord-291950-9gtsqyfj	95	5	-	-	HYPH
cord-291950-9gtsqyfj	95	6	bodyassociated	bodyassociate	VBN
cord-291950-9gtsqyfj	95	7	protein	protein	NN
cord-291950-9gtsqyfj	95	8	from	from	IN
cord-291950-9gtsqyfj	95	9	soybean	soybean	NN
cord-291950-9gtsqyfj	95	10	(	(	-LRB-
cord-291950-9gtsqyfj	95	11	UniProt	UniProt	NNP
cord-291950-9gtsqyfj	95	12	:	:	:
cord-291950-9gtsqyfj	95	13	P22895	P22895	NNP
cord-291950-9gtsqyfj	95	14	)	)	-RRB-
cord-291950-9gtsqyfj	95	15	in	in	IN
cord-291950-9gtsqyfj	95	16	which	which	WDT
cord-291950-9gtsqyfj	95	17	the	the	DT
cord-291950-9gtsqyfj	95	18	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	95	19	Cys	Cys	NNP
cord-291950-9gtsqyfj	95	20	is	be	VBZ
cord-291950-9gtsqyfj	95	21	replaced	replace	VBN
cord-291950-9gtsqyfj	95	22	by	by	IN
cord-291950-9gtsqyfj	95	23	Gly	Gly	NNP
cord-291950-9gtsqyfj	95	24	,	,	,
cord-291950-9gtsqyfj	95	25	a	a	DT
cord-291950-9gtsqyfj	95	26	surface	surface	NN
cord-291950-9gtsqyfj	95	27	protective	protective	JJ
cord-291950-9gtsqyfj	95	28	protein	protein	NN
cord-291950-9gtsqyfj	95	29	from	from	IN
cord-291950-9gtsqyfj	95	30	Plasmodium	Plasmodium	NNP
cord-291950-9gtsqyfj	95	31	(	(	-LRB-
cord-291950-9gtsqyfj	95	32	UniProt	UniProt	NNP
cord-291950-9gtsqyfj	95	33	:	:	:
cord-291950-9gtsqyfj	95	34	P08676	p08676	NN
cord-291950-9gtsqyfj	95	35	)	)	-RRB-
cord-291950-9gtsqyfj	95	36	and	and	CC
cord-291950-9gtsqyfj	95	37	a	a	DT
cord-291950-9gtsqyfj	95	38	protein	protein	NN
cord-291950-9gtsqyfj	95	39	from	from	IN
cord-291950-9gtsqyfj	95	40	Schistosoma	Schistosoma	NNP
cord-291950-9gtsqyfj	95	41	japonicum	japonicum	NN
cord-291950-9gtsqyfj	95	42	(	(	-LRB-
cord-291950-9gtsqyfj	95	43	GenBank	genbank	NN
cord-291950-9gtsqyfj	95	44	:	:	:
cord-291950-9gtsqyfj	95	45	X70969	X70969	NNP
cord-291950-9gtsqyfj	95	46	)	)	-RRB-
cord-291950-9gtsqyfj	95	47	in	in	IN
cord-291950-9gtsqyfj	95	48	which	which	WDT
cord-291950-9gtsqyfj	95	49	the	the	DT
cord-291950-9gtsqyfj	95	50	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	95	51	Cys	Cys	NNP
cord-291950-9gtsqyfj	95	52	has	have	VBZ
cord-291950-9gtsqyfj	95	53	been	be	VBN
cord-291950-9gtsqyfj	95	54	replaced	replace	VBN
cord-291950-9gtsqyfj	95	55	by	by	IN
cord-291950-9gtsqyfj	95	56	Ser	Ser	NNP
cord-291950-9gtsqyfj	95	57	.	.	.
cord-291950-9gtsqyfj	96	1	In	in	IN
cord-291950-9gtsqyfj	96	2	mammals	mammal	NNS
cord-291950-9gtsqyfj	96	3	,	,	,
cord-291950-9gtsqyfj	96	4	non	non	JJ
cord-291950-9gtsqyfj	96	5	-	-	JJ
cord-291950-9gtsqyfj	96	6	peptidase	peptidase	JJ
cord-291950-9gtsqyfj	96	7	homologs	homolog	NNS
cord-291950-9gtsqyfj	96	8	include	include	VBP
cord-291950-9gtsqyfj	96	9	FIGURE	figure	NN
cord-291950-9gtsqyfj	96	10	404.9	404.9	CD
cord-291950-9gtsqyfj	96	11	Richardson	Richardson	NNP
cord-291950-9gtsqyfj	96	12	diagram	diagram	NN
cord-291950-9gtsqyfj	96	13	of	of	IN
cord-291950-9gtsqyfj	96	14	the	the	DT
cord-291950-9gtsqyfj	96	15	human	human	JJ
cord-291950-9gtsqyfj	96	16	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	96	17	B	B	NNP
cord-291950-9gtsqyfj	96	18	/	/	SYM
cord-291950-9gtsqyfj	96	19	CA030	CA030	NNP
cord-291950-9gtsqyfj	96	20	complex	complex	JJ
cord-291950-9gtsqyfj	96	21	.	.	.
cord-291950-9gtsqyfj	97	1	The	the	DT
cord-291950-9gtsqyfj	97	2	image	image	NN
cord-291950-9gtsqyfj	97	3	was	be	VBD
cord-291950-9gtsqyfj	97	4	prepared	prepare	VBN
cord-291950-9gtsqyfj	97	5	from	from	IN
cord-291950-9gtsqyfj	97	6	the	the	DT
cord-291950-9gtsqyfj	97	7	Protein	Protein	NNP
cord-291950-9gtsqyfj	97	8	Data	Data	NNP
cord-291950-9gtsqyfj	97	9	Bank	Bank	NNP
cord-291950-9gtsqyfj	97	10	entry	entry	NN
cord-291950-9gtsqyfj	97	11	(	(	-LRB-
cord-291950-9gtsqyfj	97	12	1CSB	1csb	JJ
cord-291950-9gtsqyfj	97	13	)	)	-RRB-
cord-291950-9gtsqyfj	97	14	as	as	IN
cord-291950-9gtsqyfj	97	15	described	describe	VBN
cord-291950-9gtsqyfj	97	16	in	in	IN
cord-291950-9gtsqyfj	97	17	the	the	DT
cord-291950-9gtsqyfj	97	18	Introduction	introduction	NN
cord-291950-9gtsqyfj	97	19	(	(	-LRB-
cord-291950-9gtsqyfj	97	20	p.	p.	NN
cord-291950-9gtsqyfj	97	21	li	li	NNP
cord-291950-9gtsqyfj	97	22	)	)	-RRB-
cord-291950-9gtsqyfj	97	23	.	.	.
cord-291950-9gtsqyfj	98	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	98	2	residues	residue	NNS
cord-291950-9gtsqyfj	98	3	are	be	VBP
cord-291950-9gtsqyfj	98	4	shown	show	VBN
cord-291950-9gtsqyfj	98	5	in	in	IN
cord-291950-9gtsqyfj	98	6	ball	ball	NN
cord-291950-9gtsqyfj	98	7	-	-	HYPH
cord-291950-9gtsqyfj	98	8	and	and	CC
cord-291950-9gtsqyfj	98	9	-	-	HYPH
cord-291950-9gtsqyfj	98	10	stick	stick	NN
cord-291950-9gtsqyfj	98	11	representation	representation	NN
cord-291950-9gtsqyfj	98	12	:	:	:
cord-291950-9gtsqyfj	98	13	Cys29	Cys29	NNP
cord-291950-9gtsqyfj	98	14	,	,	,
cord-291950-9gtsqyfj	98	15	His199	his199	CD
cord-291950-9gtsqyfj	98	16	and	and	CC
cord-291950-9gtsqyfj	98	17	Asn219	Asn219	.
cord-291950-9gtsqyfj	98	18	(	(	-LRB-
cord-291950-9gtsqyfj	98	19	numbering	number	VBG
cord-291950-9gtsqyfj	98	20	as	as	IN
cord-291950-9gtsqyfj	98	21	in	in	IN
cord-291950-9gtsqyfj	98	22	PDB	PDB	NNP
cord-291950-9gtsqyfj	98	23	entry	entry	NN
cord-291950-9gtsqyfj	98	24	)	)	-RRB-
cord-291950-9gtsqyfj	98	25	.	.	.
cord-291950-9gtsqyfj	99	1	One	one	CD
cord-291950-9gtsqyfj	99	2	of	of	IN
cord-291950-9gtsqyfj	99	3	the	the	DT
cord-291950-9gtsqyfj	99	4	pair	pair	NN
cord-291950-9gtsqyfj	99	5	of	of	IN
cord-291950-9gtsqyfj	99	6	histidines	histidines	NNP
cord-291950-9gtsqyfj	99	7	(	(	-LRB-
cord-291950-9gtsqyfj	99	8	His110	his110	CD
cord-291950-9gtsqyfj	99	9	)	)	-RRB-
cord-291950-9gtsqyfj	99	10	on	on	IN
cord-291950-9gtsqyfj	99	11	the	the	DT
cord-291950-9gtsqyfj	99	12	occluding	occlude	VBG
cord-291950-9gtsqyfj	99	13	loop	loop	NN
cord-291950-9gtsqyfj	99	14	is	be	VBZ
cord-291950-9gtsqyfj	99	15	also	also	RB
cord-291950-9gtsqyfj	99	16	shown	show	VBN
cord-291950-9gtsqyfj	99	17	in	in	IN
cord-291950-9gtsqyfj	99	18	ball	ball	NN
cord-291950-9gtsqyfj	99	19	-	-	HYPH
cord-291950-9gtsqyfj	99	20	and	and	CC
cord-291950-9gtsqyfj	99	21	-	-	HYPH
cord-291950-9gtsqyfj	99	22	stick	stick	NN
cord-291950-9gtsqyfj	99	23	representation	representation	NN
cord-291950-9gtsqyfj	99	24	.	.	.
cord-291950-9gtsqyfj	100	1	FIGURE	figure	NN
cord-291950-9gtsqyfj	100	2	404.10	404.10	CD
cord-291950-9gtsqyfj	100	3	Richardson	Richardson	NNP
cord-291950-9gtsqyfj	100	4	diagram	diagram	NN
cord-291950-9gtsqyfj	100	5	of	of	IN
cord-291950-9gtsqyfj	100	6	rat	rat	NNP
cord-291950-9gtsqyfj	100	7	procathepsin	procathepsin	NNP
cord-291950-9gtsqyfj	100	8	B.	B.	NNP
cord-291950-9gtsqyfj	101	1	The	the	DT
cord-291950-9gtsqyfj	101	2	image	image	NN
cord-291950-9gtsqyfj	101	3	was	be	VBD
cord-291950-9gtsqyfj	101	4	prepared	prepare	VBN
cord-291950-9gtsqyfj	101	5	from	from	IN
cord-291950-9gtsqyfj	101	6	the	the	DT
cord-291950-9gtsqyfj	101	7	Protein	Protein	NNP
cord-291950-9gtsqyfj	101	8	Data	Data	NNP
cord-291950-9gtsqyfj	101	9	Bank	Bank	NNP
cord-291950-9gtsqyfj	101	10	entry	entry	NN
cord-291950-9gtsqyfj	101	11	(	(	-LRB-
cord-291950-9gtsqyfj	101	12	1MIR	1mir	LS
cord-291950-9gtsqyfj	101	13	)	)	-RRB-
cord-291950-9gtsqyfj	101	14	as	as	IN
cord-291950-9gtsqyfj	101	15	described	describe	VBN
cord-291950-9gtsqyfj	101	16	in	in	IN
cord-291950-9gtsqyfj	101	17	the	the	DT
cord-291950-9gtsqyfj	101	18	Introduction	introduction	NN
cord-291950-9gtsqyfj	101	19	(	(	-LRB-
cord-291950-9gtsqyfj	101	20	p.	p.	NN
cord-291950-9gtsqyfj	101	21	li	li	NNP
cord-291950-9gtsqyfj	101	22	)	)	-RRB-
cord-291950-9gtsqyfj	101	23	.	.	.
cord-291950-9gtsqyfj	102	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	102	2	residues	residue	NNS
cord-291950-9gtsqyfj	102	3	are	be	VBP
cord-291950-9gtsqyfj	102	4	shown	show	VBN
cord-291950-9gtsqyfj	102	5	in	in	IN
cord-291950-9gtsqyfj	102	6	ball	ball	NN
cord-291950-9gtsqyfj	102	7	-	-	HYPH
cord-291950-9gtsqyfj	102	8	and	and	CC
cord-291950-9gtsqyfj	102	9	-	-	HYPH
cord-291950-9gtsqyfj	102	10	stick	stick	NN
cord-291950-9gtsqyfj	102	11	representation	representation	NN
cord-291950-9gtsqyfj	102	12	:	:	:
cord-291950-9gtsqyfj	102	13	Cys29	Cys29	NNP
cord-291950-9gtsqyfj	102	14	(	(	-LRB-
cord-291950-9gtsqyfj	102	15	engineered	engineer	VBN
cord-291950-9gtsqyfj	102	16	to	to	TO
cord-291950-9gtsqyfj	102	17	be	be	VB
cord-291950-9gtsqyfj	102	18	serine	serine	NN
cord-291950-9gtsqyfj	102	19	)	)	-RRB-
cord-291950-9gtsqyfj	102	20	,	,	,
cord-291950-9gtsqyfj	102	21	His199	his199	CD
cord-291950-9gtsqyfj	102	22	and	and	CC
cord-291950-9gtsqyfj	102	23	Asn219	Asn219	.
cord-291950-9gtsqyfj	102	24	(	(	-LRB-
cord-291950-9gtsqyfj	102	25	numbering	number	VBG
cord-291950-9gtsqyfj	102	26	as	as	IN
cord-291950-9gtsqyfj	102	27	in	in	IN
cord-291950-9gtsqyfj	102	28	PDB	PDB	NNP
cord-291950-9gtsqyfj	102	29	entry	entry	NN
cord-291950-9gtsqyfj	102	30	)	)	-RRB-
cord-291950-9gtsqyfj	102	31	.	.	.
cord-291950-9gtsqyfj	103	1	One	one	CD
cord-291950-9gtsqyfj	103	2	of	of	IN
cord-291950-9gtsqyfj	103	3	the	the	DT
cord-291950-9gtsqyfj	103	4	pair	pair	NN
cord-291950-9gtsqyfj	103	5	of	of	IN
cord-291950-9gtsqyfj	103	6	histidines	histidines	NNP
cord-291950-9gtsqyfj	103	7	(	(	-LRB-
cord-291950-9gtsqyfj	103	8	His110	his110	CD
cord-291950-9gtsqyfj	103	9	)	)	-RRB-
cord-291950-9gtsqyfj	103	10	on	on	IN
cord-291950-9gtsqyfj	103	11	the	the	DT
cord-291950-9gtsqyfj	103	12	occluding	occlude	VBG
cord-291950-9gtsqyfj	103	13	loop	loop	NN
cord-291950-9gtsqyfj	103	14	is	be	VBZ
cord-291950-9gtsqyfj	103	15	also	also	RB
cord-291950-9gtsqyfj	103	16	shown	show	VBN
cord-291950-9gtsqyfj	103	17	in	in	IN
cord-291950-9gtsqyfj	103	18	ball	ball	NN
cord-291950-9gtsqyfj	103	19	-	-	HYPH
cord-291950-9gtsqyfj	103	20	and	and	CC
cord-291950-9gtsqyfj	103	21	-	-	HYPH
cord-291950-9gtsqyfj	103	22	stick	stick	NN
cord-291950-9gtsqyfj	103	23	representation	representation	NN
cord-291950-9gtsqyfj	103	24	.	.	.
cord-291950-9gtsqyfj	104	1	The	the	DT
cord-291950-9gtsqyfj	104	2	propeptide	propeptide	NN
cord-291950-9gtsqyfj	104	3	is	be	VBZ
cord-291950-9gtsqyfj	104	4	shown	show	VBN
cord-291950-9gtsqyfj	104	5	in	in	IN
cord-291950-9gtsqyfj	104	6	gray	gray	JJ
cord-291950-9gtsqyfj	104	7	.	.	.
cord-291950-9gtsqyfj	105	1	testin	testin	NNP
cord-291950-9gtsqyfj	105	2	,	,	,
cord-291950-9gtsqyfj	105	3	which	which	WDT
cord-291950-9gtsqyfj	105	4	is	be	VBZ
cord-291950-9gtsqyfj	105	5	secreted	secrete	VBN
cord-291950-9gtsqyfj	105	6	by	by	IN
cord-291950-9gtsqyfj	105	7	Sertoli	Sertoli	NNP
cord-291950-9gtsqyfj	105	8	cells	cell	NNS
cord-291950-9gtsqyfj	105	9	of	of	IN
cord-291950-9gtsqyfj	105	10	the	the	DT
cord-291950-9gtsqyfj	105	11	testis	testis	NN
cord-291950-9gtsqyfj	105	12	but	but	CC
cord-291950-9gtsqyfj	105	13	has	have	VBZ
cord-291950-9gtsqyfj	105	14	no	no	DT
cord-291950-9gtsqyfj	105	15	known	know	VBN
cord-291950-9gtsqyfj	105	16	function	function	NN
cord-291950-9gtsqyfj	105	17	,	,	,
cord-291950-9gtsqyfj	105	18	and	and	CC
cord-291950-9gtsqyfj	105	19	tubulointerstitial	tubulointerstitial	JJ
cord-291950-9gtsqyfj	105	20	nephritis	nephritis	NN
cord-291950-9gtsqyfj	105	21	antigen	antigen	NNP
cord-291950-9gtsqyfj	105	22	,	,	,
cord-291950-9gtsqyfj	105	23	an	an	DT
cord-291950-9gtsqyfj	105	24	extracellular	extracellular	JJ
cord-291950-9gtsqyfj	105	25	matrix	matrix	NN
cord-291950-9gtsqyfj	105	26	basement	basement	NN
cord-291950-9gtsqyfj	105	27	protein	protein	NN
cord-291950-9gtsqyfj	105	28	that	that	WDT
cord-291950-9gtsqyfj	105	29	is	be	VBZ
cord-291950-9gtsqyfj	105	30	a	a	DT
cord-291950-9gtsqyfj	105	31	target	target	NN
cord-291950-9gtsqyfj	105	32	for	for	IN
cord-291950-9gtsqyfj	105	33	antibody	antibody	NN
cord-291950-9gtsqyfj	105	34	-	-	HYPH
cord-291950-9gtsqyfj	105	35	mediated	mediate	VBN
cord-291950-9gtsqyfj	105	36	interstitial	interstitial	JJ
cord-291950-9gtsqyfj	105	37	nephritis	nephritis	NN
cord-291950-9gtsqyfj	105	38	[	[	-LRB-
cord-291950-9gtsqyfj	105	39	5	5	CD
cord-291950-9gtsqyfj	105	40	]	]	-RRB-
cord-291950-9gtsqyfj	105	41	.	.	.
cord-291950-9gtsqyfj	106	1	Both	both	DT
cord-291950-9gtsqyfj	106	2	mammalian	mammalian	JJ
cord-291950-9gtsqyfj	106	3	proteins	protein	NNS
cord-291950-9gtsqyfj	106	4	have	have	VBP
cord-291950-9gtsqyfj	106	5	the	the	DT
cord-291950-9gtsqyfj	106	6	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	106	7	Cys	Cys	NNP
cord-291950-9gtsqyfj	106	8	replaced	replace	VBN
cord-291950-9gtsqyfj	106	9	by	by	IN
cord-291950-9gtsqyfj	106	10	Ser	Ser	NNP
cord-291950-9gtsqyfj	106	11	.	.	.
cord-291950-9gtsqyfj	107	1	Several	several	JJ
cord-291950-9gtsqyfj	107	2	pseudogenes	pseudogene	NNS
cord-291950-9gtsqyfj	107	3	are	be	VBP
cord-291950-9gtsqyfj	107	4	known	know	VBN
cord-291950-9gtsqyfj	107	5	in	in	IN
cord-291950-9gtsqyfj	107	6	mammals	mammal	NNS
cord-291950-9gtsqyfj	107	7	,	,	,
cord-291950-9gtsqyfj	107	8	including	include	VBG
cord-291950-9gtsqyfj	107	9	a	a	DT
cord-291950-9gtsqyfj	107	10	human	human	JJ
cord-291950-9gtsqyfj	107	11	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	107	12	L	l	NN
cord-291950-9gtsqyfj	107	13	-	-	HYPH
cord-291950-9gtsqyfj	107	14	like	like	JJ
cord-291950-9gtsqyfj	107	15	pseudogene	pseudogene	NN
cord-291950-9gtsqyfj	107	16	(	(	-LRB-
cord-291950-9gtsqyfj	107	17	GenBank	GenBank	NNP
cord-291950-9gtsqyfj	107	18	:	:	:
cord-291950-9gtsqyfj	107	19	L07772	L07772	NNP
cord-291950-9gtsqyfj	107	20	)	)	-RRB-
cord-291950-9gtsqyfj	107	21	.	.	.
cord-291950-9gtsqyfj	108	1	Family	family	NN
cord-291950-9gtsqyfj	108	2	C2	C2	NNP
cord-291950-9gtsqyfj	108	3	contains	contain	VBZ
cord-291950-9gtsqyfj	108	4	the	the	DT
cord-291950-9gtsqyfj	108	5	calpains	calpain	NNS
cord-291950-9gtsqyfj	108	6	.	.	.
cord-291950-9gtsqyfj	109	1	The	the	DT
cord-291950-9gtsqyfj	109	2	molecule	molecule	NN
cord-291950-9gtsqyfj	109	3	of	of	IN
cord-291950-9gtsqyfj	109	4	a	a	DT
cord-291950-9gtsqyfj	109	5	'	'	``
cord-291950-9gtsqyfj	109	6	typical	typical	JJ
cord-291950-9gtsqyfj	109	7	'	'	''
cord-291950-9gtsqyfj	109	8	calpain	calpain	NN
cord-291950-9gtsqyfj	109	9	is	be	VBZ
cord-291950-9gtsqyfj	109	10	a	a	DT
cord-291950-9gtsqyfj	109	11	heterodimer	heterodimer	NN
cord-291950-9gtsqyfj	109	12	of	of	IN
cord-291950-9gtsqyfj	109	13	a	a	DT
cord-291950-9gtsqyfj	109	14	heavy	heavy	JJ
cord-291950-9gtsqyfj	109	15	chain	chain	NN
cord-291950-9gtsqyfj	109	16	and	and	CC
cord-291950-9gtsqyfj	109	17	a	a	DT
cord-291950-9gtsqyfj	109	18	light	light	JJ
cord-291950-9gtsqyfj	109	19	chain	chain	NN
cord-291950-9gtsqyfj	109	20	(	(	-LRB-
cord-291950-9gtsqyfj	109	21	Chapters	chapter	NNS
cord-291950-9gtsqyfj	109	22	454	454	CD
cord-291950-9gtsqyfj	109	23	,	,	,
cord-291950-9gtsqyfj	109	24	456	456	CD
cord-291950-9gtsqyfj	109	25	)	)	-RRB-
cord-291950-9gtsqyfj	109	26	.	.	.
cord-291950-9gtsqyfj	110	1	The	the	DT
cord-291950-9gtsqyfj	110	2	heavy	heavy	JJ
cord-291950-9gtsqyfj	110	3	chain	chain	NN
cord-291950-9gtsqyfj	110	4	is	be	VBZ
cord-291950-9gtsqyfj	110	5	a	a	DT
cord-291950-9gtsqyfj	110	6	mosaic	mosaic	JJ
cord-291950-9gtsqyfj	110	7	protein	protein	NN
cord-291950-9gtsqyfj	110	8	containing	contain	VBG
cord-291950-9gtsqyfj	110	9	the	the	DT
cord-291950-9gtsqyfj	110	10	peptidase	peptidase	NN
cord-291950-9gtsqyfj	110	11	domain	domain	NN
cord-291950-9gtsqyfj	110	12	(	(	-LRB-
cord-291950-9gtsqyfj	110	13	domain	domain	NN
cord-291950-9gtsqyfj	110	14	II	ii	CD
cord-291950-9gtsqyfj	110	15	)	)	-RRB-
cord-291950-9gtsqyfj	111	1	(	(	-LRB-
cord-291950-9gtsqyfj	111	2	Figure	figure	NN
cord-291950-9gtsqyfj	111	3	404	404	CD
cord-291950-9gtsqyfj	111	4	.12	.12	NFP
cord-291950-9gtsqyfj	111	5	)	)	-RRB-
cord-291950-9gtsqyfj	111	6	and	and	CC
cord-291950-9gtsqyfj	111	7	also	also	RB
cord-291950-9gtsqyfj	111	8	a	a	DT
cord-291950-9gtsqyfj	111	9	C	c	NN
cord-291950-9gtsqyfj	111	10	-	-	HYPH
cord-291950-9gtsqyfj	111	11	terminal	terminal	NN
cord-291950-9gtsqyfj	111	12	domain	domain	NN
cord-291950-9gtsqyfj	111	13	(	(	-LRB-
cord-291950-9gtsqyfj	111	14	domain	domain	NN
cord-291950-9gtsqyfj	111	15	IV	IV	NNP
cord-291950-9gtsqyfj	111	16	)	)	-RRB-
cord-291950-9gtsqyfj	111	17	with	with	IN
cord-291950-9gtsqyfj	111	18	four	four	CD
cord-291950-9gtsqyfj	111	19	calcium	calcium	NN
cord-291950-9gtsqyfj	111	20	-	-	HYPH
cord-291950-9gtsqyfj	111	21	binding	bind	VBG
cord-291950-9gtsqyfj	111	22	EF	ef	NN
cord-291950-9gtsqyfj	111	23	-	-	HYPH
cord-291950-9gtsqyfj	111	24	hand	hand	NN
cord-291950-9gtsqyfj	111	25	structures	structure	NNS
cord-291950-9gtsqyfj	111	26	.	.	.
cord-291950-9gtsqyfj	112	1	The	the	DT
cord-291950-9gtsqyfj	112	2	calcium	calcium	NN
cord-291950-9gtsqyfj	112	3	-	-	HYPH
cord-291950-9gtsqyfj	112	4	binding	bind	VBG
cord-291950-9gtsqyfj	112	5	domain	domain	NN
cord-291950-9gtsqyfj	112	6	is	be	VBZ
cord-291950-9gtsqyfj	112	7	homologous	homologous	JJ
cord-291950-9gtsqyfj	112	8	to	to	IN
cord-291950-9gtsqyfj	112	9	calciumbinding	calciumbinde	VBG
cord-291950-9gtsqyfj	112	10	domains	domain	NNS
cord-291950-9gtsqyfj	112	11	in	in	IN
cord-291950-9gtsqyfj	112	12	other	other	JJ
cord-291950-9gtsqyfj	112	13	proteins	protein	NNS
cord-291950-9gtsqyfj	112	14	.	.	.
cord-291950-9gtsqyfj	113	1	The	the	DT
cord-291950-9gtsqyfj	113	2	functions	function	NNS
cord-291950-9gtsqyfj	113	3	of	of	IN
cord-291950-9gtsqyfj	113	4	heavy	heavy	JJ
cord-291950-9gtsqyfj	113	5	chain	chain	NN
cord-291950-9gtsqyfj	113	6	domains	domain	NNS
cord-291950-9gtsqyfj	113	7	I	-PRON-	PRP
cord-291950-9gtsqyfj	113	8	and	and	CC
cord-291950-9gtsqyfj	113	9	III	III	NNP
cord-291950-9gtsqyfj	113	10	are	be	VBP
cord-291950-9gtsqyfj	113	11	unknown	unknown	JJ
cord-291950-9gtsqyfj	113	12	.	.	.
cord-291950-9gtsqyfj	114	1	Crystal	crystal	NN
cord-291950-9gtsqyfj	114	2	structures	structure	NNS
cord-291950-9gtsqyfj	114	3	of	of	IN
cord-291950-9gtsqyfj	114	4	calcium	calcium	NN
cord-291950-9gtsqyfj	114	5	-	-	HYPH
cord-291950-9gtsqyfj	114	6	free	free	JJ
cord-291950-9gtsqyfj	114	7	human	human	JJ
cord-291950-9gtsqyfj	114	8	calpain	calpain	NNS
cord-291950-9gtsqyfj	114	9	have	have	VBP
cord-291950-9gtsqyfj	114	10	been	be	VBN
cord-291950-9gtsqyfj	114	11	described	describe	VBN
cord-291950-9gtsqyfj	114	12	[	[	-LRB-
cord-291950-9gtsqyfj	114	13	6	6	CD
cord-291950-9gtsqyfj	114	14	,	,	,
cord-291950-9gtsqyfj	114	15	7	7	CD
cord-291950-9gtsqyfj	114	16	]	]	-RRB-
cord-291950-9gtsqyfj	114	17	,	,	,
cord-291950-9gtsqyfj	114	18	and	and	CC
cord-291950-9gtsqyfj	114	19	they	-PRON-	PRP
cord-291950-9gtsqyfj	114	20	show	show	VBP
cord-291950-9gtsqyfj	114	21	that	that	IN
cord-291950-9gtsqyfj	114	22	in	in	IN
cord-291950-9gtsqyfj	114	23	the	the	DT
cord-291950-9gtsqyfj	114	24	absence	absence	NN
cord-291950-9gtsqyfj	114	25	of	of	IN
cord-291950-9gtsqyfj	114	26	calcium	calcium	NN
cord-291950-9gtsqyfj	114	27	the	the	DT
cord-291950-9gtsqyfj	114	28	peptidase	peptidase	NN
cord-291950-9gtsqyfj	114	29	unit	unit	NN
cord-291950-9gtsqyfj	114	30	adopts	adopt	VBZ
cord-291950-9gtsqyfj	114	31	a	a	DT
cord-291950-9gtsqyfj	114	32	conformation	conformation	NN
cord-291950-9gtsqyfj	114	33	that	that	WDT
cord-291950-9gtsqyfj	114	34	disrupts	disrupt	VBZ
cord-291950-9gtsqyfj	114	35	the	the	DT
cord-291950-9gtsqyfj	114	36	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	114	37	site	site	NN
cord-291950-9gtsqyfj	114	38	.	.	.
cord-291950-9gtsqyfj	115	1	In	in	IN
cord-291950-9gtsqyfj	115	2	most	most	JJS
cord-291950-9gtsqyfj	115	3	mammalian	mammalian	JJ
cord-291950-9gtsqyfj	115	4	cells	cell	NNS
cord-291950-9gtsqyfj	115	5	there	there	EX
cord-291950-9gtsqyfj	115	6	are	be	VBP
cord-291950-9gtsqyfj	115	7	two	two	CD
cord-291950-9gtsqyfj	115	8	calpains	calpain	NNS
cord-291950-9gtsqyfj	115	9	with	with	IN
cord-291950-9gtsqyfj	115	10	different	different	JJ
cord-291950-9gtsqyfj	115	11	calcium	calcium	NN
cord-291950-9gtsqyfj	115	12	requirements	requirement	NNS
cord-291950-9gtsqyfj	115	13	for	for	IN
cord-291950-9gtsqyfj	115	14	activity	activity	NN
cord-291950-9gtsqyfj	115	15	:	:	:
cord-291950-9gtsqyfj	115	16	calpain-1	calpain-1	NNP
cord-291950-9gtsqyfj	115	17	(	(	-LRB-
cord-291950-9gtsqyfj	115	18	Chapter	chapter	NN
cord-291950-9gtsqyfj	115	19	454	454	CD
cord-291950-9gtsqyfj	115	20	)	)	-RRB-
cord-291950-9gtsqyfj	115	21	and	and	CC
cord-291950-9gtsqyfj	115	22	calpain-2	calpain-2	NNP
cord-291950-9gtsqyfj	115	23	(	(	-LRB-
cord-291950-9gtsqyfj	115	24	Chapter	chapter	NN
cord-291950-9gtsqyfj	115	25	455	455	CD
cord-291950-9gtsqyfj	115	26	)	)	-RRB-
cord-291950-9gtsqyfj	115	27	.	.	.
cord-291950-9gtsqyfj	116	1	Calpain	Calpain	NNP
cord-291950-9gtsqyfj	116	2	3	3	CD
cord-291950-9gtsqyfj	116	3	(	(	-LRB-
cord-291950-9gtsqyfj	116	4	Chapter	chapter	NN
cord-291950-9gtsqyfj	116	5	456	456	CD
cord-291950-9gtsqyfj	116	6	)	)	-RRB-
cord-291950-9gtsqyfj	116	7	has	have	VBZ
cord-291950-9gtsqyfj	116	8	a	a	DT
cord-291950-9gtsqyfj	116	9	48	48	CD
cord-291950-9gtsqyfj	116	10	residue	residue	NN
cord-291950-9gtsqyfj	116	11	insert	insert	NN
cord-291950-9gtsqyfj	116	12	in	in	IN
cord-291950-9gtsqyfj	116	13	the	the	DT
cord-291950-9gtsqyfj	116	14	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	116	15	domain	domain	NN
cord-291950-9gtsqyfj	116	16	between	between	IN
cord-291950-9gtsqyfj	116	17	the	the	DT
cord-291950-9gtsqyfj	116	18	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	116	19	Cys	Cys	NNP
cord-291950-9gtsqyfj	116	20	and	and	CC
cord-291950-9gtsqyfj	116	21	His	-PRON-	PRP$
cord-291950-9gtsqyfj	116	22	.	.	.
cord-291950-9gtsqyfj	117	1	A	a	DT
cord-291950-9gtsqyfj	117	2	number	number	NN
cord-291950-9gtsqyfj	117	3	of	of	IN
cord-291950-9gtsqyfj	117	4	atypical	atypical	JJ
cord-291950-9gtsqyfj	117	5	calpains	calpain	NNS
cord-291950-9gtsqyfj	117	6	are	be	VBP
cord-291950-9gtsqyfj	117	7	known	know	VBN
cord-291950-9gtsqyfj	117	8	,	,	,
cord-291950-9gtsqyfj	117	9	in	in	IN
cord-291950-9gtsqyfj	117	10	which	which	WDT
cord-291950-9gtsqyfj	117	11	the	the	DT
cord-291950-9gtsqyfj	117	12	domains	domain	NNS
cord-291950-9gtsqyfj	117	13	N	N	NNP
cord-291950-9gtsqyfj	117	14	-	-	HYPH
cord-291950-9gtsqyfj	117	15	terminal	terminal	NN
cord-291950-9gtsqyfj	117	16	and	and	CC
cord-291950-9gtsqyfj	117	17	C	c	NN
cord-291950-9gtsqyfj	117	18	-	-	HYPH
cord-291950-9gtsqyfj	117	19	terminal	terminal	NN
cord-291950-9gtsqyfj	117	20	to	to	IN
cord-291950-9gtsqyfj	117	21	the	the	DT
cord-291950-9gtsqyfj	117	22	protease	protease	NN
cord-291950-9gtsqyfj	117	23	domain	domain	NN
cord-291950-9gtsqyfj	117	24	are	be	VBP
cord-291950-9gtsqyfj	117	25	different	different	JJ
cord-291950-9gtsqyfj	117	26	from	from	IN
cord-291950-9gtsqyfj	117	27	those	those	DT
cord-291950-9gtsqyfj	117	28	in	in	IN
cord-291950-9gtsqyfj	117	29	the	the	DT
cord-291950-9gtsqyfj	117	30	typical	typical	JJ
cord-291950-9gtsqyfj	117	31	calpains	calpain	NNS
cord-291950-9gtsqyfj	117	32	,	,	,
cord-291950-9gtsqyfj	117	33	and	and	CC
cord-291950-9gtsqyfj	117	34	a	a	DT
cord-291950-9gtsqyfj	117	35	small	small	JJ
cord-291950-9gtsqyfj	117	36	subunit	subunit	NN
cord-291950-9gtsqyfj	117	37	may	may	MD
cord-291950-9gtsqyfj	117	38	not	not	RB
cord-291950-9gtsqyfj	117	39	be	be	VB
cord-291950-9gtsqyfj	117	40	required	require	VBN
cord-291950-9gtsqyfj	117	41	for	for	IN
cord-291950-9gtsqyfj	117	42	activity	activity	NN
cord-291950-9gtsqyfj	117	43	.	.	.
cord-291950-9gtsqyfj	118	1	A	a	DT
cord-291950-9gtsqyfj	118	2	Drosophila	Drosophila	NNP
cord-291950-9gtsqyfj	118	3	homolog	homolog	NN
cord-291950-9gtsqyfj	118	4	of	of	IN
cord-291950-9gtsqyfj	118	5	calpain	calpain	NN
cord-291950-9gtsqyfj	118	6	possesses	possess	VBZ
cord-291950-9gtsqyfj	118	7	an	an	DT
cord-291950-9gtsqyfj	118	8	insert	insert	NN
cord-291950-9gtsqyfj	118	9	in	in	IN
cord-291950-9gtsqyfj	118	10	the	the	DT
cord-291950-9gtsqyfj	118	11	C	c	NN
cord-291950-9gtsqyfj	118	12	-	-	HYPH
cord-291950-9gtsqyfj	118	13	terminal	terminal	NN
cord-291950-9gtsqyfj	118	14	domain	domain	NN
cord-291950-9gtsqyfj	118	15	,	,	,
cord-291950-9gtsqyfj	118	16	and	and	CC
cord-291950-9gtsqyfj	118	17	there	there	EX
cord-291950-9gtsqyfj	118	18	is	be	VBZ
cord-291950-9gtsqyfj	118	19	evidence	evidence	NN
cord-291950-9gtsqyfj	118	20	that	that	IN
cord-291950-9gtsqyfj	118	21	differential	differential	JJ
cord-291950-9gtsqyfj	118	22	splicing	splicing	NN
cord-291950-9gtsqyfj	118	23	can	can	MD
cord-291950-9gtsqyfj	118	24	give	give	VB
cord-291950-9gtsqyfj	118	25	rise	rise	NN
cord-291950-9gtsqyfj	118	26	to	to	IN
cord-291950-9gtsqyfj	118	27	a	a	DT
cord-291950-9gtsqyfj	118	28	form	form	NN
cord-291950-9gtsqyfj	118	29	lacking	lack	VBG
cord-291950-9gtsqyfj	118	30	the	the	DT
cord-291950-9gtsqyfj	118	31	calcium	calcium	NN
cord-291950-9gtsqyfj	118	32	-	-	HYPH
cord-291950-9gtsqyfj	118	33	binding	bind	VBG
cord-291950-9gtsqyfj	118	34	domain	domain	NN
cord-291950-9gtsqyfj	118	35	[	[	-LRB-
cord-291950-9gtsqyfj	118	36	8	8	CD
cord-291950-9gtsqyfj	118	37	]	]	-RRB-
cord-291950-9gtsqyfj	118	38	.	.	.
cord-291950-9gtsqyfj	119	1	Another	another	DT
cord-291950-9gtsqyfj	119	2	calpain	calpain	NN
cord-291950-9gtsqyfj	119	3	homolog	homolog	NN
cord-291950-9gtsqyfj	119	4	exists	exist	VBZ
cord-291950-9gtsqyfj	119	5	in	in	IN
cord-291950-9gtsqyfj	119	6	Drosophila	Drosophila	NNP
cord-291950-9gtsqyfj	119	7	and	and	CC
cord-291950-9gtsqyfj	119	8	is	be	VBZ
cord-291950-9gtsqyfj	119	9	involved	involve	VBN
cord-291950-9gtsqyfj	119	10	in	in	IN
cord-291950-9gtsqyfj	119	11	the	the	DT
cord-291950-9gtsqyfj	119	12	development	development	NN
cord-291950-9gtsqyfj	119	13	of	of	IN
cord-291950-9gtsqyfj	119	14	the	the	DT
cord-291950-9gtsqyfj	119	15	small	small	JJ
cord-291950-9gtsqyfj	119	16	optic	optic	JJ
cord-291950-9gtsqyfj	119	17	lobe	lobe	NN
cord-291950-9gtsqyfj	119	18	.	.	.
cord-291950-9gtsqyfj	120	1	This	this	DT
cord-291950-9gtsqyfj	120	2	putative	putative	JJ
cord-291950-9gtsqyfj	120	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	120	4	is	be	VBZ
cord-291950-9gtsqyfj	120	5	the	the	DT
cord-291950-9gtsqyfj	120	6	product	product	NN
cord-291950-9gtsqyfj	120	7	of	of	IN
cord-291950-9gtsqyfj	120	8	the	the	DT
cord-291950-9gtsqyfj	120	9	sol	sol	NNP
cord-291950-9gtsqyfj	120	10	gene	gene	NN
cord-291950-9gtsqyfj	120	11	,	,	,
cord-291950-9gtsqyfj	120	12	and	and	CC
cord-291950-9gtsqyfj	120	13	the	the	DT
cord-291950-9gtsqyfj	120	14	protein	protein	NN
cord-291950-9gtsqyfj	120	15	is	be	VBZ
cord-291950-9gtsqyfj	120	16	predicted	predict	VBN
cord-291950-9gtsqyfj	120	17	to	to	TO
cord-291950-9gtsqyfj	120	18	be	be	VB
cord-291950-9gtsqyfj	120	19	multidomain	multidomain	NNP
cord-291950-9gtsqyfj	120	20	,	,	,
cord-291950-9gtsqyfj	120	21	including	include	VBG
cord-291950-9gtsqyfj	120	22	six	six	CD
cord-291950-9gtsqyfj	120	23	zinc	zinc	NN
cord-291950-9gtsqyfj	120	24	fingers	finger	NNS
cord-291950-9gtsqyfj	120	25	as	as	RB
cord-291950-9gtsqyfj	120	26	well	well	RB
cord-291950-9gtsqyfj	120	27	as	as	IN
cord-291950-9gtsqyfj	120	28	a	a	DT
cord-291950-9gtsqyfj	120	29	peptidase	peptidase	NN
cord-291950-9gtsqyfj	120	30	domain	domain	NN
cord-291950-9gtsqyfj	120	31	,	,	,
cord-291950-9gtsqyfj	120	32	but	but	CC
cord-291950-9gtsqyfj	120	33	no	no	DT
cord-291950-9gtsqyfj	120	34	calcium	calcium	NN
cord-291950-9gtsqyfj	120	35	-	-	HYPH
cord-291950-9gtsqyfj	120	36	binding	bind	VBG
cord-291950-9gtsqyfj	120	37	domain	domain	NN
cord-291950-9gtsqyfj	120	38	[	[	-LRB-
cord-291950-9gtsqyfj	120	39	9	9	CD
cord-291950-9gtsqyfj	120	40	]	]	-RRB-
cord-291950-9gtsqyfj	121	1	(	(	-LRB-
cord-291950-9gtsqyfj	121	2	Figure	figure	NN
cord-291950-9gtsqyfj	121	3	404	404	CD
cord-291950-9gtsqyfj	121	4	.12	.12	CD
cord-291950-9gtsqyfj	121	5	)	)	-RRB-
cord-291950-9gtsqyfj	121	6	.	.	.
cord-291950-9gtsqyfj	122	1	Again	again	RB
cord-291950-9gtsqyfj	122	2	,	,	,
cord-291950-9gtsqyfj	122	3	an	an	DT
cord-291950-9gtsqyfj	122	4	alternatively	alternatively	RB
cord-291950-9gtsqyfj	122	5	spliced	splice	VBN
cord-291950-9gtsqyfj	122	6	form	form	NN
cord-291950-9gtsqyfj	122	7	exists	exist	VBZ
cord-291950-9gtsqyfj	122	8	,	,	,
cord-291950-9gtsqyfj	122	9	this	this	DT
cord-291950-9gtsqyfj	122	10	time	time	NN
cord-291950-9gtsqyfj	122	11	lacking	lack	VBG
cord-291950-9gtsqyfj	122	12	the	the	DT
cord-291950-9gtsqyfj	122	13	peptidase	peptidase	NN
cord-291950-9gtsqyfj	122	14	domain	domain	NN
cord-291950-9gtsqyfj	122	15	.	.	.
cord-291950-9gtsqyfj	123	1	The	the	DT
cord-291950-9gtsqyfj	123	2	calpain	calpain	NN
cord-291950-9gtsqyfj	123	3	family	family	NN
cord-291950-9gtsqyfj	123	4	is	be	VBZ
cord-291950-9gtsqyfj	123	5	not	not	RB
cord-291950-9gtsqyfj	123	6	restricted	restrict	VBN
cord-291950-9gtsqyfj	123	7	to	to	IN
cord-291950-9gtsqyfj	123	8	animals	animal	NNS
cord-291950-9gtsqyfj	123	9	:	:	:
cord-291950-9gtsqyfj	123	10	there	there	EX
cord-291950-9gtsqyfj	123	11	are	be	VBP
cord-291950-9gtsqyfj	123	12	sequences	sequence	NNS
cord-291950-9gtsqyfj	123	13	from	from	IN
cord-291950-9gtsqyfj	123	14	fungi	fungus	NNS
cord-291950-9gtsqyfj	123	15	,	,	,
cord-291950-9gtsqyfj	123	16	including	include	VBG
cord-291950-9gtsqyfj	123	17	Aspergillus	aspergillus	NN
cord-291950-9gtsqyfj	123	18	and	and	CC
cord-291950-9gtsqyfj	123	19	Saccharomyces	Saccharomyces	NNP
cord-291950-9gtsqyfj	123	20	,	,	,
cord-291950-9gtsqyfj	123	21	the	the	DT
cord-291950-9gtsqyfj	123	22	protozoa	protozoan	NNS
cord-291950-9gtsqyfj	123	23	Trypanosoma	Trypanosoma	NNP
cord-291950-9gtsqyfj	123	24	and	and	CC
cord-291950-9gtsqyfj	123	25	Leishmania	Leishmania	NNP
cord-291950-9gtsqyfj	123	26	,	,	,
cord-291950-9gtsqyfj	123	27	the	the	DT
cord-291950-9gtsqyfj	123	28	plant	plant	NN
cord-291950-9gtsqyfj	123	29	Arabidopsis	Arabidopsis	NNP
cord-291950-9gtsqyfj	123	30	,	,	,
cord-291950-9gtsqyfj	123	31	and	and	CC
cord-291950-9gtsqyfj	123	32	the	the	DT
cord-291950-9gtsqyfj	123	33	cyanobacterium	cyanobacterium	NN
cord-291950-9gtsqyfj	123	34	Nostoc	Nostoc	NNP
cord-291950-9gtsqyfj	123	35	(	(	-LRB-
cord-291950-9gtsqyfj	123	36	but	but	CC
cord-291950-9gtsqyfj	123	37	not	not	RB
cord-291950-9gtsqyfj	123	38	Synechocystis	Synechocystis	NNP
cord-291950-9gtsqyfj	123	39	)	)	-RRB-
cord-291950-9gtsqyfj	123	40	.	.	.
cord-291950-9gtsqyfj	124	1	Homologs	Homologs	NNP
cord-291950-9gtsqyfj	124	2	are	be	VBP
cord-291950-9gtsqyfj	124	3	also	also	RB
cord-291950-9gtsqyfj	124	4	known	know	VBN
cord-291950-9gtsqyfj	124	5	from	from	IN
cord-291950-9gtsqyfj	124	6	members	member	NNS
cord-291950-9gtsqyfj	124	7	of	of	IN
cord-291950-9gtsqyfj	124	8	a	a	DT
cord-291950-9gtsqyfj	124	9	wide	wide	JJ
cord-291950-9gtsqyfj	124	10	variety	variety	NN
cord-291950-9gtsqyfj	124	11	of	of	IN
cord-291950-9gtsqyfj	124	12	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	124	13	phyla	phylum	NNS
cord-291950-9gtsqyfj	124	14	,	,	,
cord-291950-9gtsqyfj	124	15	but	but	CC
cord-291950-9gtsqyfj	124	16	homologs	homolog	NNS
cord-291950-9gtsqyfj	124	17	are	be	VBP
cord-291950-9gtsqyfj	124	18	absent	absent	JJ
cord-291950-9gtsqyfj	124	19	from	from	IN
cord-291950-9gtsqyfj	124	20	archaea	archaea	NNS
cord-291950-9gtsqyfj	124	21	.	.	.
cord-291950-9gtsqyfj	125	1	The	the	DT
cord-291950-9gtsqyfj	125	2	only	only	JJ
cord-291950-9gtsqyfj	125	3	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	125	4	homolog	homolog	NN
cord-291950-9gtsqyfj	125	5	that	that	WDT
cord-291950-9gtsqyfj	125	6	has	have	VBZ
cord-291950-9gtsqyfj	125	7	been	be	VBN
cord-291950-9gtsqyfj	125	8	characterized	characterize	VBN
cord-291950-9gtsqyfj	125	9	is	be	VBZ
cord-291950-9gtsqyfj	125	10	the	the	DT
cord-291950-9gtsqyfj	125	11	Tpr	Tpr	NNP
cord-291950-9gtsqyfj	125	12	peptidase	peptidase	NN
cord-291950-9gtsqyfj	125	13	from	from	IN
cord-291950-9gtsqyfj	125	14	Porphyromonas	Porphyromonas	NNP
cord-291950-9gtsqyfj	125	15	gingivalis	gingivalis	NNP
cord-291950-9gtsqyfj	125	16	,	,	,
cord-291950-9gtsqyfj	125	17	which	which	WDT
cord-291950-9gtsqyfj	125	18	is	be	VBZ
cord-291950-9gtsqyfj	125	19	so	so	RB
cord-291950-9gtsqyfj	125	20	dissimilar	dissimilar	JJ
cord-291950-9gtsqyfj	125	21	in	in	IN
cord-291950-9gtsqyfj	125	22	sequence	sequence	NN
cord-291950-9gtsqyfj	125	23	to	to	IN
cord-291950-9gtsqyfj	125	24	other	other	JJ
cord-291950-9gtsqyfj	125	25	members	member	NNS
cord-291950-9gtsqyfj	125	26	of	of	IN
cord-291950-9gtsqyfj	125	27	the	the	DT
cord-291950-9gtsqyfj	125	28	family	family	NN
cord-291950-9gtsqyfj	125	29	that	that	IN
cord-291950-9gtsqyfj	125	30	it	-PRON-	PRP
cord-291950-9gtsqyfj	125	31	had	have	VBD
cord-291950-9gtsqyfj	125	32	been	be	VBN
cord-291950-9gtsqyfj	125	33	considered	consider	VBN
cord-291950-9gtsqyfj	125	34	a	a	DT
cord-291950-9gtsqyfj	125	35	member	member	NN
cord-291950-9gtsqyfj	125	36	of	of	IN
cord-291950-9gtsqyfj	125	37	a	a	DT
cord-291950-9gtsqyfj	125	38	separate	separate	JJ
cord-291950-9gtsqyfj	125	39	family	family	NN
cord-291950-9gtsqyfj	125	40	,	,	,
cord-291950-9gtsqyfj	125	41	and	and	CC
cord-291950-9gtsqyfj	125	42	is	be	VBZ
cord-291950-9gtsqyfj	125	43	now	now	RB
cord-291950-9gtsqyfj	125	44	the	the	DT
cord-291950-9gtsqyfj	125	45	only	only	JJ
cord-291950-9gtsqyfj	125	46	representative	representative	NN
cord-291950-9gtsqyfj	125	47	in	in	IN
cord-291950-9gtsqyfj	125	48	subfamily	subfamily	NN
cord-291950-9gtsqyfj	125	49	C2B.	c2b.	VB
cord-291950-9gtsqyfj	126	1	The	the	DT
cord-291950-9gtsqyfj	126	2	absence	absence	NN
cord-291950-9gtsqyfj	126	3	of	of	IN
cord-291950-9gtsqyfj	126	4	homologs	homolog	NNS
cord-291950-9gtsqyfj	126	5	from	from	IN
cord-291950-9gtsqyfj	126	6	archaea	archaea	NNS
cord-291950-9gtsqyfj	126	7	and	and	CC
cord-291950-9gtsqyfj	126	8	many	many	JJ
cord-291950-9gtsqyfj	126	9	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	126	10	with	with	IN
cord-291950-9gtsqyfj	126	11	completely	completely	RB
cord-291950-9gtsqyfj	126	12	sequenced	sequence	VBN
cord-291950-9gtsqyfj	126	13	genomes	genome	NNS
cord-291950-9gtsqyfj	126	14	,	,	,
cord-291950-9gtsqyfj	126	15	implies	imply	VBZ
cord-291950-9gtsqyfj	126	16	that	that	IN
cord-291950-9gtsqyfj	126	17	horizontal	horizontal	JJ
cord-291950-9gtsqyfj	126	18	gene	gene	NN
cord-291950-9gtsqyfj	126	19	transfer	transfer	NN
cord-291950-9gtsqyfj	126	20	has	have	VBZ
cord-291950-9gtsqyfj	126	21	occurred	occur	VBN
cord-291950-9gtsqyfj	126	22	,	,	,
cord-291950-9gtsqyfj	126	23	probably	probably	RB
cord-291950-9gtsqyfj	126	24	from	from	IN
cord-291950-9gtsqyfj	126	25	a	a	DT
cord-291950-9gtsqyfj	126	26	protist	protist	NN
cord-291950-9gtsqyfj	126	27	or	or	CC
cord-291950-9gtsqyfj	126	28	fungus	fungus	NN
cord-291950-9gtsqyfj	126	29	to	to	IN
cord-291950-9gtsqyfj	126	30	a	a	DT
cord-291950-9gtsqyfj	126	31	bacterium	bacterium	NN
cord-291950-9gtsqyfj	126	32	(	(	-LRB-
cord-291950-9gtsqyfj	126	33	see	see	VB
cord-291950-9gtsqyfj	126	34	the	the	DT
cord-291950-9gtsqyfj	126	35	evolutionary	evolutionary	JJ
cord-291950-9gtsqyfj	126	36	tree	tree	NN
cord-291950-9gtsqyfj	126	37	in	in	IN
cord-291950-9gtsqyfj	126	38	the	the	DT
cord-291950-9gtsqyfj	126	39	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	126	40	database	database	NN
cord-291950-9gtsqyfj	126	41	)	)	-RRB-
cord-291950-9gtsqyfj	126	42	.	.	.
cord-291950-9gtsqyfj	127	1	Aspergillus	aspergillus	NN
cord-291950-9gtsqyfj	127	2	palB	palB	VBZ
cord-291950-9gtsqyfj	127	3	protein	protein	NN
cord-291950-9gtsqyfj	127	4	and	and	CC
cord-291950-9gtsqyfj	127	5	a	a	DT
cord-291950-9gtsqyfj	127	6	hypothetical	hypothetical	JJ
cord-291950-9gtsqyfj	127	7	protein	protein	NN
cord-291950-9gtsqyfj	127	8	from	from	IN
cord-291950-9gtsqyfj	127	9	Caenorhabditis	Caenorhabditis	NNP
cord-291950-9gtsqyfj	127	10	are	be	VBP
cord-291950-9gtsqyfj	127	11	unusual	unusual	JJ
cord-291950-9gtsqyfj	127	12	among	among	IN
cord-291950-9gtsqyfj	127	13	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	127	14	in	in	IN
cord-291950-9gtsqyfj	127	15	clan	clan	NN
cord-291950-9gtsqyfj	127	16	CA	CA	NNP
cord-291950-9gtsqyfj	127	17	in	in	IN
cord-291950-9gtsqyfj	127	18	that	that	IN
cord-291950-9gtsqyfj	127	19	the	the	DT
cord-291950-9gtsqyfj	127	20	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	127	21	Cys	Cys	NNP
cord-291950-9gtsqyfj	127	22	is	be	VBZ
cord-291950-9gtsqyfj	127	23	followed	follow	VBN
cord-291950-9gtsqyfj	127	24	by	by	IN
cord-291950-9gtsqyfj	127	25	Ser	Ser	NNP
cord-291950-9gtsqyfj	127	26	rather	rather	RB
cord-291950-9gtsqyfj	127	27	than	than	IN
cord-291950-9gtsqyfj	127	28	a	a	DT
cord-291950-9gtsqyfj	127	29	hydrophobic	hydrophobic	JJ
cord-291950-9gtsqyfj	127	30	residue	residue	NN
cord-291950-9gtsqyfj	127	31	(	(	-LRB-
cord-291950-9gtsqyfj	127	32	see	see	VB
cord-291950-9gtsqyfj	127	33	the	the	DT
cord-291950-9gtsqyfj	127	34	alignment	alignment	NN
cord-291950-9gtsqyfj	127	35	in	in	IN
cord-291950-9gtsqyfj	127	36	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	127	37	)	)	-RRB-
cord-291950-9gtsqyfj	127	38	.	.	.
cord-291950-9gtsqyfj	128	1	Both	both	DT
cord-291950-9gtsqyfj	128	2	the	the	DT
cord-291950-9gtsqyfj	128	3	Aspergillus	Aspergillus	NNP
cord-291950-9gtsqyfj	128	4	and	and	CC
cord-291950-9gtsqyfj	128	5	Caenorhabditis	Caenorhabditis	NNP
cord-291950-9gtsqyfj	128	6	proteins	protein	NNS
cord-291950-9gtsqyfj	128	7	are	be	VBP
cord-291950-9gtsqyfj	128	8	multidomain	multidomain	NN
cord-291950-9gtsqyfj	128	9	,	,	,
cord-291950-9gtsqyfj	128	10	but	but	CC
cord-291950-9gtsqyfj	128	11	show	show	VBP
cord-291950-9gtsqyfj	128	12	only	only	RB
cord-291950-9gtsqyfj	128	13	limited	limited	JJ
cord-291950-9gtsqyfj	128	14	sequence	sequence	NN
cord-291950-9gtsqyfj	128	15	similarity	similarity	NN
cord-291950-9gtsqyfj	128	16	to	to	IN
cord-291950-9gtsqyfj	128	17	domains	domain	NNS
cord-291950-9gtsqyfj	128	18	I	-PRON-	PRP
cord-291950-9gtsqyfj	128	19	and	and	CC
cord-291950-9gtsqyfj	128	20	III	iii	CD
cord-291950-9gtsqyfj	128	21	of	of	IN
cord-291950-9gtsqyfj	128	22	human	human	JJ
cord-291950-9gtsqyfj	128	23	calpain	calpain	NN
cord-291950-9gtsqyfj	128	24	.	.	.
cord-291950-9gtsqyfj	129	1	Neither	neither	DT
cord-291950-9gtsqyfj	129	2	protein	protein	NN
cord-291950-9gtsqyfj	129	3	possesses	possess	VBZ
cord-291950-9gtsqyfj	129	4	the	the	DT
cord-291950-9gtsqyfj	129	5	calcium	calcium	NN
cord-291950-9gtsqyfj	129	6	-	-	HYPH
cord-291950-9gtsqyfj	129	7	binding	bind	VBG
cord-291950-9gtsqyfj	129	8	domain	domain	NN
cord-291950-9gtsqyfj	129	9	IV	IV	NNP
cord-291950-9gtsqyfj	129	10	.	.	.
cord-291950-9gtsqyfj	130	1	A	a	DT
cord-291950-9gtsqyfj	130	2	non	non	JJ
cord-291950-9gtsqyfj	130	3	-	-	JJ
cord-291950-9gtsqyfj	130	4	peptidase	peptidase	JJ
cord-291950-9gtsqyfj	130	5	homolog	homolog	NN
cord-291950-9gtsqyfj	130	6	is	be	VBZ
cord-291950-9gtsqyfj	130	7	known	know	VBN
cord-291950-9gtsqyfj	130	8	from	from	IN
cord-291950-9gtsqyfj	130	9	Trypanosoma	Trypanosoma	NNP
cord-291950-9gtsqyfj	130	10	brucei	brucei	NNP
cord-291950-9gtsqyfj	130	11	in	in	IN
cord-291950-9gtsqyfj	130	12	which	which	WDT
cord-291950-9gtsqyfj	130	13	the	the	DT
cord-291950-9gtsqyfj	130	14	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	130	15	Cys	Cys	NNP
cord-291950-9gtsqyfj	130	16	has	have	VBZ
cord-291950-9gtsqyfj	130	17	been	be	VBN
cord-291950-9gtsqyfj	130	18	replaced	replace	VBN
cord-291950-9gtsqyfj	130	19	by	by	IN
cord-291950-9gtsqyfj	130	20	Ser	Ser	NNP
cord-291950-9gtsqyfj	130	21	.	.	.
cord-291950-9gtsqyfj	131	1	Family	Family	NNP
cord-291950-9gtsqyfj	131	2	C10	C10	NNP
cord-291950-9gtsqyfj	131	3	contains	contain	VBZ
cord-291950-9gtsqyfj	131	4	streptopain	streptopain	NNP
cord-291950-9gtsqyfj	131	5	(	(	-LRB-
cord-291950-9gtsqyfj	131	6	Chapter	chapter	NN
cord-291950-9gtsqyfj	131	7	483	483	CD
cord-291950-9gtsqyfj	131	8	)	)	-RRB-
cord-291950-9gtsqyfj	131	9	and	and	CC
cord-291950-9gtsqyfj	131	10	a	a	DT
cord-291950-9gtsqyfj	131	11	few	few	JJ
cord-291950-9gtsqyfj	131	12	similar	similar	JJ
cord-291950-9gtsqyfj	131	13	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	131	14	,	,	,
cord-291950-9gtsqyfj	131	15	all	all	DT
cord-291950-9gtsqyfj	131	16	of	of	IN
cord-291950-9gtsqyfj	131	17	which	which	WDT
cord-291950-9gtsqyfj	131	18	are	be	VBP
cord-291950-9gtsqyfj	131	19	from	from	IN
cord-291950-9gtsqyfj	131	20	gram	gram	NN
cord-291950-9gtsqyfj	131	21	-	-	HYPH
cord-291950-9gtsqyfj	131	22	positive	positive	JJ
cord-291950-9gtsqyfj	131	23	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	131	24	.	.	.
cord-291950-9gtsqyfj	132	1	Streptopain	Streptopain	NNP
cord-291950-9gtsqyfj	132	2	is	be	VBZ
cord-291950-9gtsqyfj	132	3	inactivated	inactivate	VBN
cord-291950-9gtsqyfj	132	4	by	by	IN
cord-291950-9gtsqyfj	132	5	E-64	E-64	NNP
cord-291950-9gtsqyfj	132	6	much	much	RB
cord-291950-9gtsqyfj	132	7	more	more	RBR
cord-291950-9gtsqyfj	132	8	slowly	slowly	RB
cord-291950-9gtsqyfj	132	9	than	than	IN
cord-291950-9gtsqyfj	132	10	papain	papain	NN
cord-291950-9gtsqyfj	132	11	,	,	,
cord-291950-9gtsqyfj	132	12	but	but	CC
cord-291950-9gtsqyfj	132	13	has	have	VBZ
cord-291950-9gtsqyfj	132	14	a	a	DT
cord-291950-9gtsqyfj	132	15	similar	similar	JJ
cord-291950-9gtsqyfj	132	16	specificity	specificity	NN
cord-291950-9gtsqyfj	132	17	,	,	,
cord-291950-9gtsqyfj	132	18	with	with	IN
cord-291950-9gtsqyfj	132	19	a	a	DT
cord-291950-9gtsqyfj	132	20	preference	preference	NN
cord-291950-9gtsqyfj	132	21	for	for	IN
cord-291950-9gtsqyfj	132	22	a	a	DT
cord-291950-9gtsqyfj	132	23	hydrophobic	hydrophobic	JJ
cord-291950-9gtsqyfj	132	24	residue	residue	NN
cord-291950-9gtsqyfj	132	25	at	at	IN
cord-291950-9gtsqyfj	132	26	P2	P2	NNP
cord-291950-9gtsqyfj	132	27	[	[	-LRB-
cord-291950-9gtsqyfj	132	28	10	10	CD
cord-291950-9gtsqyfj	132	29	,	,	,
cord-291950-9gtsqyfj	132	30	11	11	CD
cord-291950-9gtsqyfj	132	31	]	]	-RRB-
cord-291950-9gtsqyfj	132	32	.	.	.
cord-291950-9gtsqyfj	133	1	In	in	IN
cord-291950-9gtsqyfj	133	2	some	some	DT
cord-291950-9gtsqyfj	133	3	members	member	NNS
cord-291950-9gtsqyfj	133	4	of	of	IN
cord-291950-9gtsqyfj	133	5	the	the	DT
cord-291950-9gtsqyfj	133	6	family	family	NN
cord-291950-9gtsqyfj	133	7	,	,	,
cord-291950-9gtsqyfj	133	8	Asn308	Asn308	,
cord-291950-9gtsqyfj	133	9	(	(	-LRB-
cord-291950-9gtsqyfj	133	10	numbering	number	VBG
cord-291950-9gtsqyfj	133	11	as	as	IN
cord-291950-9gtsqyfj	133	12	in	in	IN
cord-291950-9gtsqyfj	133	13	Figure	figure	NN
cord-291950-9gtsqyfj	133	14	404	404	CD
cord-291950-9gtsqyfj	133	15	.7	.7	NFP
cord-291950-9gtsqyfj	133	16	)	)	-RRB-
cord-291950-9gtsqyfj	133	17	is	be	VBZ
cord-291950-9gtsqyfj	133	18	replaced	replace	VBN
cord-291950-9gtsqyfj	133	19	by	by	IN
cord-291950-9gtsqyfj	133	20	Asp	Asp	NNP
cord-291950-9gtsqyfj	133	21	.	.	.
cord-291950-9gtsqyfj	134	1	The	the	DT
cord-291950-9gtsqyfj	134	2	prtT	prtT	JJR
cord-291950-9gtsqyfj	134	3	peptidase	peptidase	NN
cord-291950-9gtsqyfj	134	4	from	from	IN
cord-291950-9gtsqyfj	134	5	Porphyromonas	Porphyromonas	NNP
cord-291950-9gtsqyfj	134	6	is	be	VBZ
cord-291950-9gtsqyfj	134	7	a	a	DT
cord-291950-9gtsqyfj	134	8	mosaic	mosaic	JJ
cord-291950-9gtsqyfj	134	9	protein	protein	NN
cord-291950-9gtsqyfj	134	10	with	with	IN
cord-291950-9gtsqyfj	134	11	a	a	DT
cord-291950-9gtsqyfj	134	12	C	c	NN
cord-291950-9gtsqyfj	134	13	-	-	HYPH
cord-291950-9gtsqyfj	134	14	terminal	terminal	NN
cord-291950-9gtsqyfj	134	15	hemagglutinin	hemagglutinin	NN
cord-291950-9gtsqyfj	134	16	domain	domain	NN
cord-291950-9gtsqyfj	134	17	unrelated	unrelated	JJ
cord-291950-9gtsqyfj	134	18	to	to	IN
cord-291950-9gtsqyfj	134	19	those	those	DT
cord-291950-9gtsqyfj	134	20	in	in	IN
cord-291950-9gtsqyfj	134	21	gingipains	gingipain	NNS
cord-291950-9gtsqyfj	134	22	R	R	NNP
cord-291950-9gtsqyfj	134	23	and	and	CC
cord-291950-9gtsqyfj	134	24	K	K	NNP
cord-291950-9gtsqyfj	134	25	in	in	IN
cord-291950-9gtsqyfj	134	26	family	family	NN
cord-291950-9gtsqyfj	134	27	C25	C25	NNP
cord-291950-9gtsqyfj	134	28	but	but	CC
cord-291950-9gtsqyfj	134	29	98	98	CD
cord-291950-9gtsqyfj	134	30	%	%	NN
cord-291950-9gtsqyfj	134	31	identical	identical	JJ
cord-291950-9gtsqyfj	134	32	to	to	IN
cord-291950-9gtsqyfj	134	33	the	the	DT
cord-291950-9gtsqyfj	134	34	C	C	NNP
cord-291950-9gtsqyfj	134	35	-	-	HYPH
cord-291950-9gtsqyfj	134	36	terminal	terminal	NN
cord-291950-9gtsqyfj	134	37	domain	domain	NN
cord-291950-9gtsqyfj	134	38	of	of	IN
cord-291950-9gtsqyfj	134	39	hemin	hemin	NN
cord-291950-9gtsqyfj	134	40	-	-	HYPH
cord-291950-9gtsqyfj	134	41	regulated	regulate	VBN
cord-291950-9gtsqyfj	134	42	protein	protein	NN
cord-291950-9gtsqyfj	134	43	from	from	IN
cord-291950-9gtsqyfj	134	44	Porphyromonas	Porphyromonas	NNP
cord-291950-9gtsqyfj	134	45	(	(	-LRB-
cord-291950-9gtsqyfj	134	46	UniProt	UniProt	NNP
cord-291950-9gtsqyfj	134	47	:	:	:
cord-291950-9gtsqyfj	134	48	P72198	P72198	NNP
cord-291950-9gtsqyfj	134	49	)	)	-RRB-
cord-291950-9gtsqyfj	134	50	.	.	.
cord-291950-9gtsqyfj	135	1	Surprisingly	surprisingly	RB
cord-291950-9gtsqyfj	135	2	,	,	,
cord-291950-9gtsqyfj	135	3	streptopain	streptopain	NNP
cord-291950-9gtsqyfj	135	4	homologs	homolog	NNS
cord-291950-9gtsqyfj	135	5	are	be	VBP
cord-291950-9gtsqyfj	135	6	found	find	VBN
cord-291950-9gtsqyfj	135	7	in	in	IN
cord-291950-9gtsqyfj	135	8	some	some	DT
cord-291950-9gtsqyfj	135	9	Bacteroides	Bacteroides	NNP
cord-291950-9gtsqyfj	135	10	species	specie	NNS
cord-291950-9gtsqyfj	135	11	but	but	CC
cord-291950-9gtsqyfj	135	12	not	not	RB
cord-291950-9gtsqyfj	135	13	others	other	NNS
cord-291950-9gtsqyfj	135	14	.	.	.
cord-291950-9gtsqyfj	136	1	There	there	EX
cord-291950-9gtsqyfj	136	2	are	be	VBP
cord-291950-9gtsqyfj	136	3	several	several	JJ
cord-291950-9gtsqyfj	136	4	families	family	NNS
cord-291950-9gtsqyfj	136	5	in	in	IN
cord-291950-9gtsqyfj	136	6	clan	clan	NN
cord-291950-9gtsqyfj	136	7	CA	CA	NNP
cord-291950-9gtsqyfj	136	8	in	in	IN
cord-291950-9gtsqyfj	136	9	which	which	WDT
cord-291950-9gtsqyfj	136	10	the	the	DT
cord-291950-9gtsqyfj	136	11	peptidases	peptidases	NNPS
cord-291950-9gtsqyfj	136	12	release	release	VBP
cord-291950-9gtsqyfj	136	13	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	136	14	from	from	IN
cord-291950-9gtsqyfj	136	15	conjugated	conjugated	JJ
cord-291950-9gtsqyfj	136	16	proteins	protein	NNS
cord-291950-9gtsqyfj	136	17	.	.	.
cord-291950-9gtsqyfj	137	1	Ubiquitin	Ubiquitin	NNP
cord-291950-9gtsqyfj	137	2	is	be	VBZ
cord-291950-9gtsqyfj	137	3	a	a	DT
cord-291950-9gtsqyfj	137	4	76	76	CD
cord-291950-9gtsqyfj	137	5	amino	amino	NN
cord-291950-9gtsqyfj	137	6	acid	acid	NN
cord-291950-9gtsqyfj	137	7	protein	protein	NN
cord-291950-9gtsqyfj	137	8	that	that	WDT
cord-291950-9gtsqyfj	137	9	is	be	VBZ
cord-291950-9gtsqyfj	137	10	attached	attach	VBN
cord-291950-9gtsqyfj	137	11	to	to	IN
cord-291950-9gtsqyfj	137	12	other	other	JJ
cord-291950-9gtsqyfj	137	13	proteins	protein	NNS
cord-291950-9gtsqyfj	137	14	as	as	IN
cord-291950-9gtsqyfj	137	15	a	a	DT
cord-291950-9gtsqyfj	137	16	signal	signal	NN
cord-291950-9gtsqyfj	137	17	for	for	IN
cord-291950-9gtsqyfj	137	18	intracellular	intracellular	JJ
cord-291950-9gtsqyfj	137	19	translocation	translocation	NN
cord-291950-9gtsqyfj	137	20	or	or	CC
cord-291950-9gtsqyfj	137	21	degradation	degradation	NN
cord-291950-9gtsqyfj	137	22	(	(	-LRB-
cord-291950-9gtsqyfj	137	23	usually	usually	RB
cord-291950-9gtsqyfj	137	24	mediated	mediate	VBN
cord-291950-9gtsqyfj	137	25	by	by	IN
cord-291950-9gtsqyfj	137	26	the	the	DT
cord-291950-9gtsqyfj	137	27	proteasome	proteasome	NN
cord-291950-9gtsqyfj	137	28	)	)	-RRB-
cord-291950-9gtsqyfj	137	29	.	.	.
cord-291950-9gtsqyfj	138	1	Ubiquitin	Ubiquitin	NNP
cord-291950-9gtsqyfj	138	2	is	be	VBZ
cord-291950-9gtsqyfj	138	3	attached	attach	VBN
cord-291950-9gtsqyfj	138	4	through	through	IN
cord-291950-9gtsqyfj	138	5	the	the	DT
cord-291950-9gtsqyfj	138	6	carboxyl	carboxyl	NN
cord-291950-9gtsqyfj	138	7	group	group	NN
cord-291950-9gtsqyfj	138	8	of	of	IN
cord-291950-9gtsqyfj	138	9	its	-PRON-	PRP$
cord-291950-9gtsqyfj	138	10	C	C	NNP
cord-291950-9gtsqyfj	138	11	-	-	HYPH
cord-291950-9gtsqyfj	138	12	terminal	terminal	NN
cord-291950-9gtsqyfj	138	13	glycine	glycine	NN
cord-291950-9gtsqyfj	138	14	residue	residue	NN
cord-291950-9gtsqyfj	138	15	either	either	CC
cord-291950-9gtsqyfj	138	16	to	to	IN
cord-291950-9gtsqyfj	138	17	the	the	DT
cord-291950-9gtsqyfj	138	18	N	n	NN
cord-291950-9gtsqyfj	138	19	-	-	HYPH
cord-291950-9gtsqyfj	138	20	terminus	terminus	NN
cord-291950-9gtsqyfj	138	21	of	of	IN
cord-291950-9gtsqyfj	138	22	another	another	DT
cord-291950-9gtsqyfj	138	23	polypeptide	polypeptide	NN
cord-291950-9gtsqyfj	138	24	or	or	CC
cord-291950-9gtsqyfj	138	25	to	to	IN
cord-291950-9gtsqyfj	138	26	the	the	DT
cord-291950-9gtsqyfj	138	27	α	α	NN
cord-291950-9gtsqyfj	138	28	-	-	HYPH
cord-291950-9gtsqyfj	138	29	amino	amino	NN
cord-291950-9gtsqyfj	138	30	group	group	NN
cord-291950-9gtsqyfj	138	31	of	of	IN
cord-291950-9gtsqyfj	138	32	a	a	DT
cord-291950-9gtsqyfj	138	33	lysine	lysine	NN
cord-291950-9gtsqyfj	138	34	residue	residue	NN
cord-291950-9gtsqyfj	138	35	,	,	,
cord-291950-9gtsqyfj	138	36	which	which	WDT
cord-291950-9gtsqyfj	138	37	forms	form	VBZ
cord-291950-9gtsqyfj	138	38	an	an	DT
cord-291950-9gtsqyfj	138	39	isopeptide	isopeptide	NN
cord-291950-9gtsqyfj	138	40	bond	bond	NN
cord-291950-9gtsqyfj	138	41	(	(	-LRB-
cord-291950-9gtsqyfj	138	42	Chapters	chapter	NNS
cord-291950-9gtsqyfj	138	43	460À462	460à462	CD
cord-291950-9gtsqyfj	138	44	)	)	-RRB-
cord-291950-9gtsqyfj	138	45	.	.	.
cord-291950-9gtsqyfj	139	1	Ubiquitin	Ubiquitin	NNP
cord-291950-9gtsqyfj	139	2	may	may	MD
cord-291950-9gtsqyfj	139	3	also	also	RB
cord-291950-9gtsqyfj	139	4	be	be	VB
cord-291950-9gtsqyfj	139	5	attached	attach	VBN
cord-291950-9gtsqyfj	139	6	to	to	IN
cord-291950-9gtsqyfj	139	7	another	another	DT
cord-291950-9gtsqyfj	139	8	molecule	molecule	NN
cord-291950-9gtsqyfj	139	9	of	of	IN
cord-291950-9gtsqyfj	139	10	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	139	11	,	,	,
cord-291950-9gtsqyfj	139	12	and	and	CC
cord-291950-9gtsqyfj	139	13	proteins	protein	NNS
cord-291950-9gtsqyfj	139	14	targeted	target	VBN
cord-291950-9gtsqyfj	139	15	for	for	IN
cord-291950-9gtsqyfj	139	16	degradation	degradation	NN
cord-291950-9gtsqyfj	139	17	may	may	MD
cord-291950-9gtsqyfj	139	18	be	be	VB
cord-291950-9gtsqyfj	139	19	polyubiquitinated	polyubiquitinate	VBN
cord-291950-9gtsqyfj	139	20	.	.	.
cord-291950-9gtsqyfj	140	1	In	in	IN
cord-291950-9gtsqyfj	140	2	order	order	NN
cord-291950-9gtsqyfj	140	3	for	for	IN
cord-291950-9gtsqyfj	140	4	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	140	5	to	to	TO
cord-291950-9gtsqyfj	140	6	be	be	VB
cord-291950-9gtsqyfj	140	7	recycled	recycle	VBN
cord-291950-9gtsqyfj	140	8	there	there	EX
cord-291950-9gtsqyfj	140	9	is	be	VBZ
cord-291950-9gtsqyfj	140	10	a	a	DT
cord-291950-9gtsqyfj	140	11	need	need	NN
cord-291950-9gtsqyfj	140	12	for	for	IN
cord-291950-9gtsqyfj	140	13	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	140	14	to	to	TO
cord-291950-9gtsqyfj	140	15	liberate	liberate	VB
cord-291950-9gtsqyfj	140	16	the	the	DT
cord-291950-9gtsqyfj	140	17	free	free	JJ
cord-291950-9gtsqyfj	140	18	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	140	19	by	by	IN
cord-291950-9gtsqyfj	140	20	hydrolysis	hydrolysis	NN
cord-291950-9gtsqyfj	140	21	of	of	IN
cord-291950-9gtsqyfj	140	22	the	the	DT
cord-291950-9gtsqyfj	140	23	C	C	NNP
cord-291950-9gtsqyfj	140	24	-	-	HYPH
cord-291950-9gtsqyfj	140	25	terminal	terminal	JJ
cord-291950-9gtsqyfj	140	26	glycyl	glycyl	NNP
cord-291950-9gtsqyfj	140	27	bond	bond	NNP
cord-291950-9gtsqyfj	140	28	.	.	.
cord-291950-9gtsqyfj	141	1	Peptidases	peptidase	NNS
cord-291950-9gtsqyfj	141	2	that	that	WDT
cord-291950-9gtsqyfj	141	3	release	release	VBP
cord-291950-9gtsqyfj	141	4	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	141	5	from	from	IN
cord-291950-9gtsqyfj	141	6	conjugates	conjugate	NNS
cord-291950-9gtsqyfj	141	7	are	be	VBP
cord-291950-9gtsqyfj	141	8	known	know	VBN
cord-291950-9gtsqyfj	141	9	as	as	IN
cord-291950-9gtsqyfj	141	10	'	'	``
cord-291950-9gtsqyfj	141	11	ubiquitin	ubiquitin	NNP
cord-291950-9gtsqyfj	141	12	C	c	NN
cord-291950-9gtsqyfj	141	13	-	-	HYPH
cord-291950-9gtsqyfj	141	14	terminal	terminal	NN
cord-291950-9gtsqyfj	141	15	hydrolases	hydrolase	NNS
cord-291950-9gtsqyfj	141	16	'	'	POS
cord-291950-9gtsqyfj	141	17	or	or	CC
cord-291950-9gtsqyfj	141	18	'	'	``
cord-291950-9gtsqyfj	141	19	deubiquitinylating	deubiquitinylate	VBG
cord-291950-9gtsqyfj	141	20	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	141	21	'	'	''
cord-291950-9gtsqyfj	141	22	.	.	.
cord-291950-9gtsqyfj	142	1	Because	because	IN
cord-291950-9gtsqyfj	142	2	release	release	NN
cord-291950-9gtsqyfj	142	3	of	of	IN
cord-291950-9gtsqyfj	142	4	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	142	5	may	may	MD
cord-291950-9gtsqyfj	142	6	involve	involve	VB
cord-291950-9gtsqyfj	142	7	cleavage	cleavage	NN
cord-291950-9gtsqyfj	142	8	of	of	IN
cord-291950-9gtsqyfj	142	9	an	an	DT
cord-291950-9gtsqyfj	142	10	isopeptide	isopeptide	NN
cord-291950-9gtsqyfj	142	11	bond	bond	NN
cord-291950-9gtsqyfj	142	12	,	,	,
cord-291950-9gtsqyfj	142	13	ubiquitin	ubiquitin	NNP
cord-291950-9gtsqyfj	142	14	C	c	NN
cord-291950-9gtsqyfj	142	15	-	-	HYPH
cord-291950-9gtsqyfj	142	16	terminal	terminal	NN
cord-291950-9gtsqyfj	142	17	hydrolases	hydrolase	NNS
cord-291950-9gtsqyfj	142	18	are	be	VBP
cord-291950-9gtsqyfj	142	19	not	not	RB
cord-291950-9gtsqyfj	142	20	classified	classify	VBN
cord-291950-9gtsqyfj	142	21	as	as	IN
cord-291950-9gtsqyfj	142	22	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	142	23	in	in	IN
cord-291950-9gtsqyfj	142	24	Enzyme	Enzyme	NNP
cord-291950-9gtsqyfj	142	25	Nomenclature	Nomenclature	NNP
cord-291950-9gtsqyfj	142	26	but	but	CC
cord-291950-9gtsqyfj	142	27	as	as	IN
cord-291950-9gtsqyfj	142	28	thiolester	thiolester	NN
cord-291950-9gtsqyfj	142	29	hydrolases	hydrolase	NNS
cord-291950-9gtsqyfj	142	30	.	.	.
cord-291950-9gtsqyfj	143	1	There	there	EX
cord-291950-9gtsqyfj	143	2	are	be	VBP
cord-291950-9gtsqyfj	143	3	at	at	RB
cord-291950-9gtsqyfj	143	4	least	least	RBS
cord-291950-9gtsqyfj	143	5	eight	eight	CD
cord-291950-9gtsqyfj	143	6	families	family	NNS
cord-291950-9gtsqyfj	143	7	of	of	IN
cord-291950-9gtsqyfj	143	8	deubiquitinylating	deubiquitinylate	VBG
cord-291950-9gtsqyfj	143	9	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	143	10	in	in	IN
cord-291950-9gtsqyfj	143	11	clan	clan	NN
cord-291950-9gtsqyfj	143	12	CA	CA	NNP
cord-291950-9gtsqyfj	143	13	,	,	,
cord-291950-9gtsqyfj	143	14	and	and	CC
cord-291950-9gtsqyfj	143	15	there	there	EX
cord-291950-9gtsqyfj	143	16	are	be	VBP
cord-291950-9gtsqyfj	143	17	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	143	18	in	in	IN
cord-291950-9gtsqyfj	143	19	other	other	JJ
cord-291950-9gtsqyfj	143	20	,	,	,
cord-291950-9gtsqyfj	143	21	unrelated	unrelated	JJ
cord-291950-9gtsqyfj	143	22	,	,	,
cord-291950-9gtsqyfj	143	23	families	family	NNS
cord-291950-9gtsqyfj	143	24	,	,	,
cord-291950-9gtsqyfj	143	25	including	include	VBG
cord-291950-9gtsqyfj	143	26	the	the	DT
cord-291950-9gtsqyfj	143	27	metallopeptidase	metallopeptidase	NN
cord-291950-9gtsqyfj	143	28	AMSH	AMSH	NNP
cord-291950-9gtsqyfj	143	29	(	(	-LRB-
cord-291950-9gtsqyfj	143	30	family	family	NN
cord-291950-9gtsqyfj	143	31	M67	M67	NNP
cord-291950-9gtsqyfj	143	32	)	)	-RRB-
cord-291950-9gtsqyfj	143	33	which	which	WDT
cord-291950-9gtsqyfj	143	34	is	be	VBZ
cord-291950-9gtsqyfj	143	35	a	a	DT
cord-291950-9gtsqyfj	143	36	component	component	NN
cord-291950-9gtsqyfj	143	37	of	of	IN
cord-291950-9gtsqyfj	143	38	the	the	DT
cord-291950-9gtsqyfj	143	39	26S	26S	NNP
cord-291950-9gtsqyfj	143	40	proteasome	proteasome	NN
cord-291950-9gtsqyfj	143	41	(	(	-LRB-
cord-291950-9gtsqyfj	143	42	Chapter	chapter	NN
cord-291950-9gtsqyfj	143	43	817	817	CD
cord-291950-9gtsqyfj	143	44	)	)	-RRB-
cord-291950-9gtsqyfj	143	45	.	.	.
cord-291950-9gtsqyfj	144	1	There	there	EX
cord-291950-9gtsqyfj	144	2	are	be	VBP
cord-291950-9gtsqyfj	144	3	over	over	IN
cord-291950-9gtsqyfj	144	4	100	100	CD
cord-291950-9gtsqyfj	144	5	different	different	JJ
cord-291950-9gtsqyfj	144	6	deubiquitinylating	deubiquitinylate	VBG
cord-291950-9gtsqyfj	144	7	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	144	8	in	in	IN
cord-291950-9gtsqyfj	144	9	humans	human	NNS
cord-291950-9gtsqyfj	144	10	,	,	,
cord-291950-9gtsqyfj	144	11	which	which	WDT
cord-291950-9gtsqyfj	144	12	implies	imply	VBZ
cord-291950-9gtsqyfj	144	13	a	a	DT
cord-291950-9gtsqyfj	144	14	sophisticated	sophisticated	JJ
cord-291950-9gtsqyfj	144	15	network	network	NN
cord-291950-9gtsqyfj	144	16	controlling	control	VBG
cord-291950-9gtsqyfj	144	17	translocation	translocation	NN
cord-291950-9gtsqyfj	144	18	and	and	CC
cord-291950-9gtsqyfj	144	19	degradation	degradation	NN
cord-291950-9gtsqyfj	144	20	of	of	IN
cord-291950-9gtsqyfj	144	21	proteins	protein	NNS
cord-291950-9gtsqyfj	144	22	which	which	WDT
cord-291950-9gtsqyfj	144	23	is	be	VBZ
cord-291950-9gtsqyfj	144	24	only	only	RB
cord-291950-9gtsqyfj	144	25	just	just	RB
cord-291950-9gtsqyfj	144	26	being	be	VBG
cord-291950-9gtsqyfj	144	27	understood	understand	VBN
cord-291950-9gtsqyfj	144	28	.	.	.
cord-291950-9gtsqyfj	145	1	Family	Family	NNP
cord-291950-9gtsqyfj	145	2	C12	C12	NNP
cord-291950-9gtsqyfj	145	3	includes	include	VBZ
cord-291950-9gtsqyfj	145	4	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	145	5	that	that	WDT
cord-291950-9gtsqyfj	145	6	can	can	MD
cord-291950-9gtsqyfj	145	7	hydrolyze	hydrolyze	VB
cord-291950-9gtsqyfj	145	8	the	the	DT
cord-291950-9gtsqyfj	145	9	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	145	10	-	-	HYPH
cord-291950-9gtsqyfj	145	11	conjugate	conjugate	JJ
cord-291950-9gtsqyfj	145	12	glycyl	glycyl	JJ
cord-291950-9gtsqyfj	145	13	bond	bond	NN
cord-291950-9gtsqyfj	145	14	whether	whether	IN
cord-291950-9gtsqyfj	145	15	it	-PRON-	PRP
cord-291950-9gtsqyfj	145	16	is	be	VBZ
cord-291950-9gtsqyfj	145	17	an	an	DT
cord-291950-9gtsqyfj	145	18	α	α	NN
cord-291950-9gtsqyfj	145	19	-	-	HYPH
cord-291950-9gtsqyfj	145	20	peptide	peptide	NN
cord-291950-9gtsqyfj	145	21	bond	bond	NN
cord-291950-9gtsqyfj	145	22	or	or	CC
cord-291950-9gtsqyfj	145	23	an	an	DT
cord-291950-9gtsqyfj	145	24	isopeptide	isopeptide	NN
cord-291950-9gtsqyfj	145	25	bond	bond	NN
cord-291950-9gtsqyfj	145	26	,	,	,
cord-291950-9gtsqyfj	145	27	with	with	IN
cord-291950-9gtsqyfj	145	28	various	various	JJ
cord-291950-9gtsqyfj	145	29	specificities	specificity	NNS
cord-291950-9gtsqyfj	145	30	.	.	.
cord-291950-9gtsqyfj	146	1	The	the	DT
cord-291950-9gtsqyfj	146	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	146	3	structure	structure	NN
cord-291950-9gtsqyfj	146	4	of	of	IN
cord-291950-9gtsqyfj	146	5	the	the	DT
cord-291950-9gtsqyfj	146	6	human	human	JJ
cord-291950-9gtsqyfj	146	7	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	146	8	C	C	NNP
cord-291950-9gtsqyfj	146	9	-	-	HYPH
cord-291950-9gtsqyfj	146	10	terminal	terminal	NN
cord-291950-9gtsqyfj	146	11	hydrolase	hydrolase	NN
cord-291950-9gtsqyfj	146	12	UCH	UCH	NNP
cord-291950-9gtsqyfj	146	13	-	-	HYPH
cord-291950-9gtsqyfj	146	14	L3	L3	NNP
cord-291950-9gtsqyfj	146	15	has	have	VBZ
cord-291950-9gtsqyfj	146	16	been	be	VBN
cord-291950-9gtsqyfj	146	17	solved	solve	VBN
cord-291950-9gtsqyfj	146	18	[	[	-LRB-
cord-291950-9gtsqyfj	146	19	12	12	CD
cord-291950-9gtsqyfj	146	20	]	]	-RRB-
cord-291950-9gtsqyfj	146	21	,	,	,
cord-291950-9gtsqyfj	146	22	and	and	CC
cord-291950-9gtsqyfj	146	23	is	be	VBZ
cord-291950-9gtsqyfj	146	24	shown	show	VBN
cord-291950-9gtsqyfj	146	25	in	in	IN
cord-291950-9gtsqyfj	146	26	Figure	figure	NN
cord-291950-9gtsqyfj	146	27	404	404	CD
cord-291950-9gtsqyfj	146	28	.4	.4	NFP
cord-291950-9gtsqyfj	146	29	.	.	.
cord-291950-9gtsqyfj	147	1	There	there	EX
cord-291950-9gtsqyfj	147	2	are	be	VBP
cord-291950-9gtsqyfj	147	3	many	many	JJ
cord-291950-9gtsqyfj	147	4	structural	structural	JJ
cord-291950-9gtsqyfj	147	5	similarities	similarity	NNS
cord-291950-9gtsqyfj	147	6	to	to	IN
cord-291950-9gtsqyfj	147	7	papain	papain	NN
cord-291950-9gtsqyfj	147	8	.	.	.
cord-291950-9gtsqyfj	148	1	The	the	DT
cord-291950-9gtsqyfj	148	2	molecule	molecule	NN
cord-291950-9gtsqyfj	148	3	is	be	VBZ
cord-291950-9gtsqyfj	148	4	bilobed	bilobe	VBN
cord-291950-9gtsqyfj	148	5	,	,	,
cord-291950-9gtsqyfj	148	6	one	one	CD
cord-291950-9gtsqyfj	148	7	lobe	lobe	NN
cord-291950-9gtsqyfj	148	8	consisting	consist	VBG
cord-291950-9gtsqyfj	148	9	mainly	mainly	RB
cord-291950-9gtsqyfj	148	10	of	of	IN
cord-291950-9gtsqyfj	148	11	helices	helix	NNS
cord-291950-9gtsqyfj	148	12	,	,	,
cord-291950-9gtsqyfj	148	13	the	the	DT
cord-291950-9gtsqyfj	148	14	other	other	JJ
cord-291950-9gtsqyfj	148	15	containing	contain	VBG
cord-291950-9gtsqyfj	148	16	a	a	DT
cord-291950-9gtsqyfj	148	17	β	β	NN
cord-291950-9gtsqyfj	148	18	-	-	HYPH
cord-291950-9gtsqyfj	148	19	barrel	barrel	NN
cord-291950-9gtsqyfj	148	20	surrounded	surround	VBN
cord-291950-9gtsqyfj	148	21	by	by	IN
cord-291950-9gtsqyfj	148	22	helices	helix	NNS
cord-291950-9gtsqyfj	148	23	.	.	.
cord-291950-9gtsqyfj	149	1	The	the	DT
cord-291950-9gtsqyfj	149	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	149	3	Cys	Cys	NNP
cord-291950-9gtsqyfj	149	4	is	be	VBZ
cord-291950-9gtsqyfj	149	5	at	at	IN
cord-291950-9gtsqyfj	149	6	the	the	DT
cord-291950-9gtsqyfj	149	7	start	start	NN
cord-291950-9gtsqyfj	149	8	of	of	IN
cord-291950-9gtsqyfj	149	9	one	one	CD
cord-291950-9gtsqyfj	149	10	of	of	IN
cord-291950-9gtsqyfj	149	11	the	the	DT
cord-291950-9gtsqyfj	149	12	helices	helix	NNS
cord-291950-9gtsqyfj	149	13	,	,	,
cord-291950-9gtsqyfj	149	14	and	and	CC
cord-291950-9gtsqyfj	149	15	the	the	DT
cord-291950-9gtsqyfj	149	16	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	150	1	His	-PRON-	PRP$
cord-291950-9gtsqyfj	150	2	is	be	VBZ
cord-291950-9gtsqyfj	150	3	the	the	DT
cord-291950-9gtsqyfj	150	4	start	start	NN
cord-291950-9gtsqyfj	150	5	of	of	IN
cord-291950-9gtsqyfj	150	6	a	a	DT
cord-291950-9gtsqyfj	150	7	β	β	NN
cord-291950-9gtsqyfj	150	8	strand	strand	NN
cord-291950-9gtsqyfj	150	9	.	.	.
cord-291950-9gtsqyfj	151	1	A	a	DT
cord-291950-9gtsqyfj	151	2	difference	difference	NN
cord-291950-9gtsqyfj	151	3	from	from	IN
cord-291950-9gtsqyfj	151	4	papain	papain	NN
cord-291950-9gtsqyfj	151	5	is	be	VBZ
cord-291950-9gtsqyfj	151	6	that	that	IN
cord-291950-9gtsqyfj	151	7	the	the	DT
cord-291950-9gtsqyfj	151	8	first	first	JJ
cord-291950-9gtsqyfj	151	9	strand	strand	NN
cord-291950-9gtsqyfj	151	10	of	of	IN
cord-291950-9gtsqyfj	151	11	the	the	DT
cord-291950-9gtsqyfj	151	12	β	β	NN
cord-291950-9gtsqyfj	151	13	-	-	HYPH
cord-291950-9gtsqyfj	151	14	barrel	barrel	NN
cord-291950-9gtsqyfj	151	15	precedes	precede	VBZ
cord-291950-9gtsqyfj	151	16	the	the	DT
cord-291950-9gtsqyfj	151	17	helix	helix	NN
cord-291950-9gtsqyfj	151	18	bearing	bear	VBG
cord-291950-9gtsqyfj	151	19	the	the	DT
cord-291950-9gtsqyfj	151	20	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	151	21	cysteine	cysteine	NN
cord-291950-9gtsqyfj	151	22	in	in	IN
cord-291950-9gtsqyfj	151	23	the	the	DT
cord-291950-9gtsqyfj	151	24	sequence	sequence	NN
cord-291950-9gtsqyfj	151	25	,	,	,
cord-291950-9gtsqyfj	151	26	whereas	whereas	IN
cord-291950-9gtsqyfj	151	27	in	in	IN
cord-291950-9gtsqyfj	151	28	papain	papain	NN
cord-291950-9gtsqyfj	151	29	the	the	DT
cord-291950-9gtsqyfj	151	30	helix	helix	NN
cord-291950-9gtsqyfj	151	31	precedes	precede	VBZ
cord-291950-9gtsqyfj	151	32	all	all	PDT
cord-291950-9gtsqyfj	151	33	the	the	DT
cord-291950-9gtsqyfj	151	34	strands	strand	NNS
cord-291950-9gtsqyfj	151	35	of	of	IN
cord-291950-9gtsqyfj	151	36	the	the	DT
cord-291950-9gtsqyfj	151	37	β	β	NN
cord-291950-9gtsqyfj	151	38	-	-	HYPH
cord-291950-9gtsqyfj	151	39	barrel	barrel	NN
cord-291950-9gtsqyfj	151	40	.	.	.
cord-291950-9gtsqyfj	152	1	The	the	DT
cord-291950-9gtsqyfj	152	2	spacing	spacing	NN
cord-291950-9gtsqyfj	152	3	between	between	IN
cord-291950-9gtsqyfj	152	4	Gln152	gln152	NN
cord-291950-9gtsqyfj	152	5	and	and	CC
cord-291950-9gtsqyfj	152	6	Cys158	cys158	LS
cord-291950-9gtsqyfj	152	7	(	(	-LRB-
cord-291950-9gtsqyfj	152	8	numbering	number	VBG
cord-291950-9gtsqyfj	152	9	as	as	IN
cord-291950-9gtsqyfj	152	10	in	in	IN
cord-291950-9gtsqyfj	152	11	Figure	figure	NN
cord-291950-9gtsqyfj	152	12	404	404	CD
cord-291950-9gtsqyfj	152	13	.7	.7	NFP
cord-291950-9gtsqyfj	152	14	)	)	-RRB-
cord-291950-9gtsqyfj	152	15	is	be	VBZ
cord-291950-9gtsqyfj	152	16	identical	identical	JJ
cord-291950-9gtsqyfj	152	17	to	to	IN
cord-291950-9gtsqyfj	152	18	that	that	DT
cord-291950-9gtsqyfj	152	19	in	in	IN
cord-291950-9gtsqyfj	152	20	families	family	NNS
cord-291950-9gtsqyfj	152	21	C1	C1	NNP
cord-291950-9gtsqyfj	152	22	,	,	,
cord-291950-9gtsqyfj	152	23	C2	C2	NNP
cord-291950-9gtsqyfj	152	24	and	and	CC
cord-291950-9gtsqyfj	152	25	C10	C10	NNP
cord-291950-9gtsqyfj	152	26	.	.	.
cord-291950-9gtsqyfj	153	1	Peptidases	peptidase	NNS
cord-291950-9gtsqyfj	153	2	in	in	IN
cord-291950-9gtsqyfj	153	3	family	family	NN
cord-291950-9gtsqyfj	153	4	C12	C12	NNP
cord-291950-9gtsqyfj	153	5	are	be	VBP
cord-291950-9gtsqyfj	153	6	synthesized	synthesize	VBN
cord-291950-9gtsqyfj	153	7	without	without	IN
cord-291950-9gtsqyfj	153	8	propeptides	propeptide	NNS
cord-291950-9gtsqyfj	153	9	,	,	,
cord-291950-9gtsqyfj	153	10	and	and	CC
cord-291950-9gtsqyfj	153	11	are	be	VBP
cord-291950-9gtsqyfj	153	12	intracellular	intracellular	JJ
cord-291950-9gtsqyfj	153	13	;	;	:
cord-291950-9gtsqyfj	153	14	they	-PRON-	PRP
cord-291950-9gtsqyfj	153	15	are	be	VBP
cord-291950-9gtsqyfj	153	16	known	know	VBN
cord-291950-9gtsqyfj	153	17	only	only	RB
cord-291950-9gtsqyfj	153	18	from	from	IN
cord-291950-9gtsqyfj	153	19	animals	animal	NNS
cord-291950-9gtsqyfj	153	20	,	,	,
cord-291950-9gtsqyfj	153	21	plants	plant	NNS
cord-291950-9gtsqyfj	153	22	and	and	CC
cord-291950-9gtsqyfj	153	23	fungi	fungus	NNS
cord-291950-9gtsqyfj	153	24	.	.	.
cord-291950-9gtsqyfj	154	1	Family	Family	NNP
cord-291950-9gtsqyfj	154	2	C19	C19	NNP
cord-291950-9gtsqyfj	154	3	contains	contain	VBZ
cord-291950-9gtsqyfj	154	4	the	the	DT
cord-291950-9gtsqyfj	154	5	second	second	JJ
cord-291950-9gtsqyfj	154	6	group	group	NN
cord-291950-9gtsqyfj	154	7	of	of	IN
cord-291950-9gtsqyfj	154	8	ubiquitin	ubiquitin	NNP
cord-291950-9gtsqyfj	154	9	C	C	NNP
cord-291950-9gtsqyfj	154	10	-	-	HYPH
cord-291950-9gtsqyfj	154	11	terminal	terminal	NN
cord-291950-9gtsqyfj	154	12	hydrolases	hydrolase	NNS
cord-291950-9gtsqyfj	154	13	.	.	.
cord-291950-9gtsqyfj	155	1	These	these	DT
cord-291950-9gtsqyfj	155	2	are	be	VBP
cord-291950-9gtsqyfj	155	3	also	also	RB
cord-291950-9gtsqyfj	155	4	intracellular	intracellular	JJ
cord-291950-9gtsqyfj	155	5	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	155	6	,	,	,
cord-291950-9gtsqyfj	155	7	but	but	CC
cord-291950-9gtsqyfj	155	8	are	be	VBP
cord-291950-9gtsqyfj	155	9	able	able	JJ
cord-291950-9gtsqyfj	155	10	to	to	TO
cord-291950-9gtsqyfj	155	11	release	release	VB
cord-291950-9gtsqyfj	155	12	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	155	13	from	from	IN
cord-291950-9gtsqyfj	155	14	much	much	RB
cord-291950-9gtsqyfj	155	15	larger	large	JJR
cord-291950-9gtsqyfj	155	16	peptides	peptide	NNS
cord-291950-9gtsqyfj	155	17	that	that	WDT
cord-291950-9gtsqyfj	155	18	have	have	VBP
cord-291950-9gtsqyfj	155	19	been	be	VBN
cord-291950-9gtsqyfj	155	20	polyubiquitinated	polyubiquitinate	VBN
cord-291950-9gtsqyfj	155	21	(	(	-LRB-
cord-291950-9gtsqyfj	155	22	Chapters	chapter	NNS
cord-291950-9gtsqyfj	155	23	463À473	463à473	CD
cord-291950-9gtsqyfj	155	24	)	)	-RRB-
cord-291950-9gtsqyfj	155	25	.	.	.
cord-291950-9gtsqyfj	156	1	Because	because	IN
cord-291950-9gtsqyfj	156	2	ubiquitination	ubiquitination	NN
cord-291950-9gtsqyfj	156	3	is	be	VBZ
cord-291950-9gtsqyfj	156	4	also	also	RB
cord-291950-9gtsqyfj	156	5	essential	essential	JJ
cord-291950-9gtsqyfj	156	6	for	for	IN
cord-291950-9gtsqyfj	156	7	the	the	DT
cord-291950-9gtsqyfj	156	8	assembly	assembly	NNP
cord-291950-9gtsqyfj	156	9	of	of	IN
cord-291950-9gtsqyfj	156	10	multimeric	multimeric	NNP
cord-291950-9gtsqyfj	156	11	proteins	protein	NNS
cord-291950-9gtsqyfj	156	12	,	,	,
cord-291950-9gtsqyfj	156	13	there	there	EX
cord-291950-9gtsqyfj	156	14	is	be	VBZ
cord-291950-9gtsqyfj	156	15	a	a	DT
cord-291950-9gtsqyfj	156	16	need	need	NN
cord-291950-9gtsqyfj	156	17	to	to	TO
cord-291950-9gtsqyfj	156	18	remove	remove	VB
cord-291950-9gtsqyfj	156	19	the	the	DT
cord-291950-9gtsqyfj	156	20	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	156	21	molecules	molecule	NNS
cord-291950-9gtsqyfj	156	22	from	from	IN
cord-291950-9gtsqyfj	156	23	polyubiquitinated	polyubiquitinated	JJ
cord-291950-9gtsqyfj	156	24	subunits	subunit	NNS
cord-291950-9gtsqyfj	156	25	,	,	,
cord-291950-9gtsqyfj	156	26	which	which	WDT
cord-291950-9gtsqyfj	156	27	is	be	VBZ
cord-291950-9gtsqyfj	156	28	presumably	presumably	RB
cord-291950-9gtsqyfj	156	29	one	one	CD
cord-291950-9gtsqyfj	156	30	of	of	IN
cord-291950-9gtsqyfj	156	31	the	the	DT
cord-291950-9gtsqyfj	156	32	functions	function	NNS
cord-291950-9gtsqyfj	156	33	of	of	IN
cord-291950-9gtsqyfj	156	34	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	156	35	of	of	IN
cord-291950-9gtsqyfj	156	36	family	family	NN
cord-291950-9gtsqyfj	156	37	C19	C19	NNP
cord-291950-9gtsqyfj	156	38	.	.	.
cord-291950-9gtsqyfj	157	1	Peptidases	Peptidases	NNP
cord-291950-9gtsqyfj	157	2	in	in	IN
cord-291950-9gtsqyfj	157	3	family	family	NN
cord-291950-9gtsqyfj	157	4	C19	C19	NNP
cord-291950-9gtsqyfj	157	5	have	have	VBP
cord-291950-9gtsqyfj	157	6	more	more	RBR
cord-291950-9gtsqyfj	157	7	complicated	complicated	JJ
cord-291950-9gtsqyfj	157	8	structures	structure	NNS
cord-291950-9gtsqyfj	157	9	than	than	IN
cord-291950-9gtsqyfj	157	10	those	those	DT
cord-291950-9gtsqyfj	157	11	in	in	IN
cord-291950-9gtsqyfj	157	12	C12	C12	NNP
cord-291950-9gtsqyfj	157	13	,	,	,
cord-291950-9gtsqyfj	157	14	and	and	CC
cord-291950-9gtsqyfj	157	15	many	many	JJ
cord-291950-9gtsqyfj	157	16	are	be	VBP
cord-291950-9gtsqyfj	157	17	multidomain	multidomain	NN
cord-291950-9gtsqyfj	157	18	proteins	protein	NNS
cord-291950-9gtsqyfj	157	19	.	.	.
cord-291950-9gtsqyfj	158	1	There	there	EX
cord-291950-9gtsqyfj	158	2	is	be	VBZ
cord-291950-9gtsqyfj	158	3	also	also	RB
cord-291950-9gtsqyfj	158	4	a	a	DT
cord-291950-9gtsqyfj	158	5	much	much	RB
cord-291950-9gtsqyfj	158	6	greater	great	JJR
cord-291950-9gtsqyfj	158	7	variety	variety	NN
cord-291950-9gtsqyfj	158	8	,	,	,
cord-291950-9gtsqyfj	158	9	with	with	IN
cord-291950-9gtsqyfj	158	10	Saccharomyces	saccharomyce	NNS
cord-291950-9gtsqyfj	158	11	possessing	possess	VBG
cord-291950-9gtsqyfj	158	12	at	at	RB
cord-291950-9gtsqyfj	158	13	least	least	RBS
cord-291950-9gtsqyfj	158	14	19	19	CD
cord-291950-9gtsqyfj	158	15	homologs	homolog	NNS
cord-291950-9gtsqyfj	158	16	,	,	,
cord-291950-9gtsqyfj	158	17	and	and	CC
cord-291950-9gtsqyfj	158	18	even	even	RB
cord-291950-9gtsqyfj	158	19	greater	great	JJR
cord-291950-9gtsqyfj	158	20	numbers	number	NNS
cord-291950-9gtsqyfj	158	21	in	in	IN
cord-291950-9gtsqyfj	158	22	mammals	mammal	NNS
cord-291950-9gtsqyfj	158	23	.	.	.
cord-291950-9gtsqyfj	159	1	The	the	DT
cord-291950-9gtsqyfj	159	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	159	3	structure	structure	NN
cord-291950-9gtsqyfj	159	4	of	of	IN
cord-291950-9gtsqyfj	159	5	ubiquitin	ubiquitin	JJ
cord-291950-9gtsqyfj	159	6	-	-	HYPH
cord-291950-9gtsqyfj	159	7	specific	specific	JJ
cord-291950-9gtsqyfj	159	8	peptidase	peptidase	NN
cord-291950-9gtsqyfj	159	9	7	7	CD
cord-291950-9gtsqyfj	159	10	has	have	VBZ
cord-291950-9gtsqyfj	159	11	been	be	VBN
cord-291950-9gtsqyfj	159	12	solved	solve	VBN
cord-291950-9gtsqyfj	159	13	and	and	CC
cord-291950-9gtsqyfj	159	14	a	a	DT
cord-291950-9gtsqyfj	159	15	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	159	16	triad	triad	NN
cord-291950-9gtsqyfj	159	17	consisting	consist	VBG
cord-291950-9gtsqyfj	159	18	of	of	IN
cord-291950-9gtsqyfj	159	19	Cys	Cys	NNP
cord-291950-9gtsqyfj	159	20	,	,	,
cord-291950-9gtsqyfj	159	21	His	His	NNP
cord-291950-9gtsqyfj	159	22	and	and	CC
cord-291950-9gtsqyfj	159	23	Asp	Asp	NNP
cord-291950-9gtsqyfj	159	24	was	be	VBD
cord-291950-9gtsqyfj	159	25	identified	identify	VBN
cord-291950-9gtsqyfj	159	26	(	(	-LRB-
cord-291950-9gtsqyfj	159	27	Figure	figure	NN
cord-291950-9gtsqyfj	159	28	404.13	404.13	CD
cord-291950-9gtsqyfj	159	29	;	;	:
cord-291950-9gtsqyfj	159	30	also	also	RB
cord-291950-9gtsqyfj	159	31	see	see	VB
cord-291950-9gtsqyfj	159	32	later	later	RB
cord-291950-9gtsqyfj	159	33	Figure	figure	NN
cord-291950-9gtsqyfj	159	34	404	404	CD
cord-291950-9gtsqyfj	159	35	.35	.35	CD
cord-291950-9gtsqyfj	159	36	)	)	-RRB-
cord-291950-9gtsqyfj	159	37	.	.	.
cord-291950-9gtsqyfj	160	1	The	the	DT
cord-291950-9gtsqyfj	160	2	Asp	Asp	NNP
cord-291950-9gtsqyfj	160	3	is	be	VBZ
cord-291950-9gtsqyfj	160	4	equivalent	equivalent	JJ
cord-291950-9gtsqyfj	160	5	to	to	IN
cord-291950-9gtsqyfj	160	6	the	the	DT
cord-291950-9gtsqyfj	160	7	Asn152	asn152	NN
cord-291950-9gtsqyfj	160	8	of	of	IN
cord-291950-9gtsqyfj	160	9	papain	papain	NN
cord-291950-9gtsqyfj	160	10	.	.	.
cord-291950-9gtsqyfj	161	1	The	the	DT
cord-291950-9gtsqyfj	161	2	side	side	NN
cord-291950-9gtsqyfj	161	3	chain	chain	NN
cord-291950-9gtsqyfj	161	4	of	of	IN
cord-291950-9gtsqyfj	161	5	an	an	DT
cord-291950-9gtsqyfj	161	6	asparagine	asparagine	NN
cord-291950-9gtsqyfj	161	7	stabilizes	stabilize	VBZ
cord-291950-9gtsqyfj	161	8	the	the	DT
cord-291950-9gtsqyfj	161	9	oxyanion	oxyanion	NN
cord-291950-9gtsqyfj	161	10	hole	hole	NN
cord-291950-9gtsqyfj	161	11	and	and	CC
cord-291950-9gtsqyfj	161	12	is	be	VBZ
cord-291950-9gtsqyfj	161	13	equivalent	equivalent	JJ
cord-291950-9gtsqyfj	161	14	of	of	IN
cord-291950-9gtsqyfj	161	15	Gln19	Gln19	NNP
cord-291950-9gtsqyfj	161	16	in	in	IN
cord-291950-9gtsqyfj	161	17	papain	papain	NN
cord-291950-9gtsqyfj	161	18	.	.	.
cord-291950-9gtsqyfj	162	1	The	the	DT
cord-291950-9gtsqyfj	162	2	fold	fold	NN
cord-291950-9gtsqyfj	162	3	has	have	VBZ
cord-291950-9gtsqyfj	162	4	been	be	VBN
cord-291950-9gtsqyfj	162	5	likened	liken	VBN
cord-291950-9gtsqyfj	162	6	to	to	IN
cord-291950-9gtsqyfj	162	7	that	that	DT
cord-291950-9gtsqyfj	162	8	of	of	IN
cord-291950-9gtsqyfj	162	9	an	an	DT
cord-291950-9gtsqyfj	162	10	open	open	JJ
cord-291950-9gtsqyfj	162	11	hand	hand	NN
cord-291950-9gtsqyfj	162	12	,	,	,
cord-291950-9gtsqyfj	162	13	consisting	consist	VBG
cord-291950-9gtsqyfj	162	14	of	of	IN
cord-291950-9gtsqyfj	162	15	three	three	CD
cord-291950-9gtsqyfj	162	16	subdomains	subdomain	NNS
cord-291950-9gtsqyfj	162	17	,	,	,
cord-291950-9gtsqyfj	162	18	with	with	IN
cord-291950-9gtsqyfj	162	19	the	the	DT
cord-291950-9gtsqyfj	162	20	active	active	JJ
cord-291950-9gtsqyfj	162	21	site	site	NN
cord-291950-9gtsqyfj	162	22	Cys	Cys	NNP
cord-291950-9gtsqyfj	162	23	on	on	IN
cord-291950-9gtsqyfj	162	24	the	the	DT
cord-291950-9gtsqyfj	162	25	'	'	``
cord-291950-9gtsqyfj	162	26	thumb	thumb	NN
cord-291950-9gtsqyfj	162	27	'	'	''
cord-291950-9gtsqyfj	162	28	subdomain	subdomain	NN
cord-291950-9gtsqyfj	162	29	,	,	,
cord-291950-9gtsqyfj	162	30	the	the	DT
cord-291950-9gtsqyfj	162	31	active	active	JJ
cord-291950-9gtsqyfj	162	32	site	site	NN
cord-291950-9gtsqyfj	163	1	His	-PRON-	PRP$
cord-291950-9gtsqyfj	163	2	on	on	IN
cord-291950-9gtsqyfj	163	3	the	the	DT
cord-291950-9gtsqyfj	163	4	'	'	``
cord-291950-9gtsqyfj	163	5	palm	palm	NN
cord-291950-9gtsqyfj	163	6	'	'	''
cord-291950-9gtsqyfj	163	7	and	and	CC
cord-291950-9gtsqyfj	163	8	the	the	DT
cord-291950-9gtsqyfj	163	9	active	active	JJ
cord-291950-9gtsqyfj	163	10	site	site	NN
cord-291950-9gtsqyfj	163	11	cleft	cleft	NN
cord-291950-9gtsqyfj	163	12	between	between	IN
cord-291950-9gtsqyfj	163	13	the	the	DT
cord-291950-9gtsqyfj	163	14	'	'	``
cord-291950-9gtsqyfj	163	15	thumb	thumb	NN
cord-291950-9gtsqyfj	163	16	'	'	''
cord-291950-9gtsqyfj	163	17	and	and	CC
cord-291950-9gtsqyfj	163	18	the	the	DT
cord-291950-9gtsqyfj	163	19	'	'	``
cord-291950-9gtsqyfj	163	20	palm	palm	NN
cord-291950-9gtsqyfj	163	21	.	.	.
cord-291950-9gtsqyfj	163	22	'	'	''
cord-291950-9gtsqyfj	164	1	The	the	DT
cord-291950-9gtsqyfj	164	2	'	'	``
cord-291950-9gtsqyfj	164	3	fingers	finger	NNS
cord-291950-9gtsqyfj	164	4	'	'	''
cord-291950-9gtsqyfj	164	5	interact	interact	VBP
cord-291950-9gtsqyfj	164	6	with	with	IN
cord-291950-9gtsqyfj	164	7	ubiquitin	ubiquitin	NNP
cord-291950-9gtsqyfj	164	8	[	[	-LRB-
cord-291950-9gtsqyfj	164	9	13	13	CD
cord-291950-9gtsqyfj	164	10	]	]	-RRB-
cord-291950-9gtsqyfj	164	11	.	.	.
cord-291950-9gtsqyfj	165	1	Members	member	NNS
cord-291950-9gtsqyfj	165	2	of	of	IN
cord-291950-9gtsqyfj	165	3	family	family	NN
cord-291950-9gtsqyfj	165	4	C19	C19	NNP
cord-291950-9gtsqyfj	165	5	are	be	VBP
cord-291950-9gtsqyfj	165	6	present	present	JJ
cord-291950-9gtsqyfj	165	7	in	in	IN
cord-291950-9gtsqyfj	165	8	all	all	PDT
cord-291950-9gtsqyfj	165	9	the	the	DT
cord-291950-9gtsqyfj	165	10	eukaryotic	eukaryotic	JJ
cord-291950-9gtsqyfj	165	11	genomes	genome	NNS
cord-291950-9gtsqyfj	165	12	so	so	RB
cord-291950-9gtsqyfj	165	13	far	far	RB
cord-291950-9gtsqyfj	165	14	completely	completely	RB
cord-291950-9gtsqyfj	165	15	sequenced	sequence	VBN
cord-291950-9gtsqyfj	165	16	,	,	,
cord-291950-9gtsqyfj	165	17	including	include	VBG
cord-291950-9gtsqyfj	165	18	Encephalitozoon	Encephalitozoon	NNP
cord-291950-9gtsqyfj	165	19	cuniculi	cuniculi	NNP
cord-291950-9gtsqyfj	165	20	.	.	.
cord-291950-9gtsqyfj	166	1	Family	Family	NNP
cord-291950-9gtsqyfj	166	2	C19	C19	NNP
cord-291950-9gtsqyfj	166	3	sequences	sequence	NNS
cord-291950-9gtsqyfj	166	4	are	be	VBP
cord-291950-9gtsqyfj	166	5	known	know	VBN
cord-291950-9gtsqyfj	166	6	from	from	IN
cord-291950-9gtsqyfj	166	7	several	several	JJ
cord-291950-9gtsqyfj	166	8	protozoan	protozoan	NN
cord-291950-9gtsqyfj	166	9	species	specie	NNS
cord-291950-9gtsqyfj	166	10	that	that	WDT
cord-291950-9gtsqyfj	166	11	do	do	VBP
cord-291950-9gtsqyfj	166	12	not	not	RB
cord-291950-9gtsqyfj	166	13	contain	contain	VB
cord-291950-9gtsqyfj	166	14	family	family	NN
cord-291950-9gtsqyfj	166	15	C12	C12	NNP
cord-291950-9gtsqyfj	166	16	.	.	.
cord-291950-9gtsqyfj	167	1	C19	C19	NNP
cord-291950-9gtsqyfj	167	2	homologs	homolog	NNS
cord-291950-9gtsqyfj	167	3	are	be	VBP
cord-291950-9gtsqyfj	167	4	known	know	VBN
cord-291950-9gtsqyfj	167	5	from	from	IN
cord-291950-9gtsqyfj	167	6	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	167	7	such	such	JJ
cord-291950-9gtsqyfj	167	8	as	as	IN
cord-291950-9gtsqyfj	167	9	the	the	DT
cord-291950-9gtsqyfj	167	10	pathogen	pathogen	NN
cord-291950-9gtsqyfj	167	11	Burkholderia	Burkholderia	NNP
cord-291950-9gtsqyfj	167	12	pseudomallei	pseudomallei	NN
cord-291950-9gtsqyfj	167	13	,	,	,
cord-291950-9gtsqyfj	167	14	but	but	CC
cord-291950-9gtsqyfj	167	15	the	the	DT
cord-291950-9gtsqyfj	167	16	sequences	sequence	NNS
cord-291950-9gtsqyfj	167	17	are	be	VBP
cord-291950-9gtsqyfj	167	18	shorter	short	JJR
cord-291950-9gtsqyfj	167	19	(	(	-LRB-
cord-291950-9gtsqyfj	167	20	c.	c.	NN
cord-291950-9gtsqyfj	167	21	280	280	CD
cord-291950-9gtsqyfj	167	22	residues	residue	NNS
cord-291950-9gtsqyfj	167	23	)	)	-RRB-
cord-291950-9gtsqyfj	167	24	and	and	CC
cord-291950-9gtsqyfj	167	25	lack	lack	JJ
cord-291950-9gtsqyfj	167	26	inserts	insert	NNS
cord-291950-9gtsqyfj	167	27	between	between	IN
cord-291950-9gtsqyfj	167	28	the	the	DT
cord-291950-9gtsqyfj	167	29	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	167	30	Cys	Cys	NNP
cord-291950-9gtsqyfj	167	31	and	and	CC
cord-291950-9gtsqyfj	167	32	His	-PRON-	PRP$
cord-291950-9gtsqyfj	167	33	.	.	.
cord-291950-9gtsqyfj	168	1	The	the	DT
cord-291950-9gtsqyfj	168	2	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	168	3	homologs	homolog	NNS
cord-291950-9gtsqyfj	168	4	are	be	VBP
cord-291950-9gtsqyfj	168	5	derived	derive	VBN
cord-291950-9gtsqyfj	168	6	from	from	IN
cord-291950-9gtsqyfj	168	7	the	the	DT
cord-291950-9gtsqyfj	168	8	most	most	RBS
cord-291950-9gtsqyfj	168	9	divergent	divergent	JJ
cord-291950-9gtsqyfj	168	10	branch	branch	NN
cord-291950-9gtsqyfj	168	11	in	in	IN
cord-291950-9gtsqyfj	168	12	the	the	DT
cord-291950-9gtsqyfj	168	13	evolutionary	evolutionary	JJ
cord-291950-9gtsqyfj	168	14	tree	tree	NN
cord-291950-9gtsqyfj	168	15	.	.	.
cord-291950-9gtsqyfj	169	1	The	the	DT
cord-291950-9gtsqyfj	169	2	TssM	TssM	NNP
cord-291950-9gtsqyfj	169	3	protein	protein	NN
cord-291950-9gtsqyfj	169	4	from	from	IN
cord-291950-9gtsqyfj	169	5	Burkholderia	Burkholderia	NNP
cord-291950-9gtsqyfj	169	6	mallei	mallei	NNP
cord-291950-9gtsqyfj	169	7	has	have	VBZ
cord-291950-9gtsqyfj	169	8	been	be	VBN
cord-291950-9gtsqyfj	169	9	shown	show	VBN
cord-291950-9gtsqyfj	169	10	to	to	TO
cord-291950-9gtsqyfj	169	11	be	be	VB
cord-291950-9gtsqyfj	169	12	a	a	DT
cord-291950-9gtsqyfj	169	13	deubiquitinating	deubiquitinating	NN
cord-291950-9gtsqyfj	169	14	enzyme	enzyme	NN
cord-291950-9gtsqyfj	169	15	[	[	-LRB-
cord-291950-9gtsqyfj	169	16	14	14	CD
cord-291950-9gtsqyfj	169	17	]	]	-RRB-
cord-291950-9gtsqyfj	169	18	.	.	.
cord-291950-9gtsqyfj	170	1	Other	other	JJ
cord-291950-9gtsqyfj	170	2	families	family	NNS
cord-291950-9gtsqyfj	170	3	of	of	IN
cord-291950-9gtsqyfj	170	4	deubiquitinating	deubiquitinating	NN
cord-291950-9gtsqyfj	170	5	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	170	6	were	be	VBD
cord-291950-9gtsqyfj	170	7	initially	initially	RB
cord-291950-9gtsqyfj	170	8	postulated	postulate	VBN
cord-291950-9gtsqyfj	170	9	by	by	IN
cord-291950-9gtsqyfj	170	10	Makarova	Makarova	NNP
cord-291950-9gtsqyfj	170	11	et	et	NNP
cord-291950-9gtsqyfj	170	12	al	al	NNP
cord-291950-9gtsqyfj	170	13	[	[	-LRB-
cord-291950-9gtsqyfj	170	14	15	15	CD
cord-291950-9gtsqyfj	170	15	]	]	-RRB-
cord-291950-9gtsqyfj	170	16	,	,	,
cord-291950-9gtsqyfj	170	17	which	which	WDT
cord-291950-9gtsqyfj	170	18	have	have	VBP
cord-291950-9gtsqyfj	170	19	now	now	RB
cord-291950-9gtsqyfj	170	20	been	be	VBN
cord-291950-9gtsqyfj	170	21	experimentally	experimentally	RB
cord-291950-9gtsqyfj	170	22	verified	verify	VBN
cord-291950-9gtsqyfj	170	23	.	.	.
cord-291950-9gtsqyfj	171	1	The	the	DT
cord-291950-9gtsqyfj	171	2	human	human	JJ
cord-291950-9gtsqyfj	171	3	Cezanne	Cezanne	NNP
cord-291950-9gtsqyfj	171	4	protein	protein	NN
cord-291950-9gtsqyfj	171	5	,	,	,
cord-291950-9gtsqyfj	171	6	from	from	IN
cord-291950-9gtsqyfj	171	7	family	family	NN
cord-291950-9gtsqyfj	171	8	C64	C64	NNP
cord-291950-9gtsqyfj	171	9	,	,	,
cord-291950-9gtsqyfj	171	10	was	be	VBD
cord-291950-9gtsqyfj	171	11	shown	show	VBN
cord-291950-9gtsqyfj	171	12	to	to	TO
cord-291950-9gtsqyfj	171	13	release	release	VB
cord-291950-9gtsqyfj	171	14	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	171	15	from	from	IN
cord-291950-9gtsqyfj	171	16	linear	linear	JJ
cord-291950-9gtsqyfj	171	17	or	or	CC
cord-291950-9gtsqyfj	171	18	branched	branched	JJ
cord-291950-9gtsqyfj	171	19	synthetic	synthetic	JJ
cord-291950-9gtsqyfj	171	20	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	171	21	chains	chain	NNS
cord-291950-9gtsqyfj	171	22	and	and	CC
cord-291950-9gtsqyfj	171	23	from	from	IN
cord-291950-9gtsqyfj	171	24	ubiquitinated	ubiquitinated	JJ
cord-291950-9gtsqyfj	171	25	proteins	protein	NNS
cord-291950-9gtsqyfj	171	26	[	[	-LRB-
cord-291950-9gtsqyfj	171	27	16	16	CD
cord-291950-9gtsqyfj	171	28	]	]	-RRB-
cord-291950-9gtsqyfj	171	29	,	,	,
cord-291950-9gtsqyfj	171	30	and	and	CC
cord-291950-9gtsqyfj	171	31	from	from	IN
cord-291950-9gtsqyfj	171	32	the	the	DT
cord-291950-9gtsqyfj	171	33	solved	solve	VBN
cord-291950-9gtsqyfj	171	34	structure	structure	NN
cord-291950-9gtsqyfj	171	35	of	of	IN
cord-291950-9gtsqyfj	171	36	tumor	tumor	NN
cord-291950-9gtsqyfj	171	37	necrosis	necrosis	NN
cord-291950-9gtsqyfj	171	38	factor	factor	NN
cord-291950-9gtsqyfj	171	39	α	α	NN
cord-291950-9gtsqyfj	171	40	-	-	HYPH
cord-291950-9gtsqyfj	171	41	induced	induce	VBN
cord-291950-9gtsqyfj	171	42	protein	protein	NN
cord-291950-9gtsqyfj	171	43	3	3	CD
cord-291950-9gtsqyfj	171	44	,	,	,
cord-291950-9gtsqyfj	171	45	the	the	DT
cord-291950-9gtsqyfj	171	46	fold	fold	NN
cord-291950-9gtsqyfj	171	47	was	be	VBD
cord-291950-9gtsqyfj	171	48	shown	show	VBN
cord-291950-9gtsqyfj	171	49	to	to	TO
cord-291950-9gtsqyfj	171	50	be	be	VB
cord-291950-9gtsqyfj	171	51	similar	similar	JJ
cord-291950-9gtsqyfj	171	52	to	to	IN
cord-291950-9gtsqyfj	171	53	that	that	DT
cord-291950-9gtsqyfj	171	54	of	of	IN
cord-291950-9gtsqyfj	171	55	papain	papain	NN
cord-291950-9gtsqyfj	171	56	[	[	-LRB-
cord-291950-9gtsqyfj	171	57	17	17	CD
cord-291950-9gtsqyfj	171	58	]	]	-RRB-
cord-291950-9gtsqyfj	171	59	.	.	.
cord-291950-9gtsqyfj	172	1	Family	Family	NNP
cord-291950-9gtsqyfj	172	2	C65	C65	NNP
cord-291950-9gtsqyfj	172	3	includes	include	VBZ
cord-291950-9gtsqyfj	172	4	the	the	DT
cord-291950-9gtsqyfj	172	5	otubains	otubain	NNS
cord-291950-9gtsqyfj	172	6	(	(	-LRB-
cord-291950-9gtsqyfj	172	7	see	see	VB
cord-291950-9gtsqyfj	172	8	Chapter	chapter	NN
cord-291950-9gtsqyfj	172	9	477	477	CD
cord-291950-9gtsqyfj	172	10	)	)	-RRB-
cord-291950-9gtsqyfj	172	11	.	.	.
cord-291950-9gtsqyfj	173	1	The	the	DT
cord-291950-9gtsqyfj	173	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	173	3	structure	structure	NN
cord-291950-9gtsqyfj	173	4	of	of	IN
cord-291950-9gtsqyfj	173	5	otubain-2	otubain-2	NNP
cord-291950-9gtsqyfj	173	6	has	have	VBZ
cord-291950-9gtsqyfj	173	7	been	be	VBN
cord-291950-9gtsqyfj	173	8	determined	determine	VBN
cord-291950-9gtsqyfj	173	9	and	and	CC
cord-291950-9gtsqyfj	173	10	shows	show	VBZ
cord-291950-9gtsqyfj	173	11	that	that	IN
cord-291950-9gtsqyfj	173	12	the	the	DT
cord-291950-9gtsqyfj	173	13	fold	fold	NN
cord-291950-9gtsqyfj	173	14	is	be	VBZ
cord-291950-9gtsqyfj	173	15	similar	similar	JJ
cord-291950-9gtsqyfj	173	16	to	to	IN
cord-291950-9gtsqyfj	173	17	that	that	DT
cord-291950-9gtsqyfj	173	18	of	of	IN
cord-291950-9gtsqyfj	173	19	papain	papain	NN
cord-291950-9gtsqyfj	173	20	[	[	-LRB-
cord-291950-9gtsqyfj	173	21	18	18	CD
cord-291950-9gtsqyfj	173	22	]	]	-RRB-
cord-291950-9gtsqyfj	173	23	.	.	.
cord-291950-9gtsqyfj	174	1	Otubain-1	Otubain-1	NNP
cord-291950-9gtsqyfj	174	2	has	have	VBZ
cord-291950-9gtsqyfj	174	3	been	be	VBN
cord-291950-9gtsqyfj	174	4	shown	show	VBN
cord-291950-9gtsqyfj	174	5	to	to	TO
cord-291950-9gtsqyfj	174	6	cleave	cleave	VB
cord-291950-9gtsqyfj	174	7	Lys48-linked	lys48-linke	VBN
cord-291950-9gtsqyfj	174	8	polyubiquitin	polyubiquitin	NNS
cord-291950-9gtsqyfj	174	9	[	[	-LRB-
cord-291950-9gtsqyfj	174	10	19	19	CD
cord-291950-9gtsqyfj	174	11	]	]	-RRB-
cord-291950-9gtsqyfj	174	12	.	.	.
cord-291950-9gtsqyfj	175	1	The	the	DT
cord-291950-9gtsqyfj	175	2	CylD	CylD	NNP
cord-291950-9gtsqyfj	175	3	protein	protein	NN
cord-291950-9gtsqyfj	175	4	from	from	IN
cord-291950-9gtsqyfj	175	5	family	family	NN
cord-291950-9gtsqyfj	175	6	C67	C67	NNP
cord-291950-9gtsqyfj	175	7	(	(	-LRB-
cord-291950-9gtsqyfj	175	8	see	see	VB
cord-291950-9gtsqyfj	175	9	Chapter	chapter	NN
cord-291950-9gtsqyfj	175	10	476	476	CD
cord-291950-9gtsqyfj	175	11	)	)	-RRB-
cord-291950-9gtsqyfj	175	12	has	have	VBZ
cord-291950-9gtsqyfj	175	13	been	be	VBN
cord-291950-9gtsqyfj	175	14	shown	show	VBN
cord-291950-9gtsqyfj	175	15	to	to	TO
cord-291950-9gtsqyfj	175	16	have	have	VB
cord-291950-9gtsqyfj	175	17	de	de	VBN
cord-291950-9gtsqyfj	175	18	-	-	JJ
cord-291950-9gtsqyfj	175	19	ubiquitinating	ubiquitinating	JJ
cord-291950-9gtsqyfj	175	20	activity	activity	NN
cord-291950-9gtsqyfj	175	21	that	that	WDT
cord-291950-9gtsqyfj	175	22	is	be	VBZ
cord-291950-9gtsqyfj	175	23	directed	direct	VBN
cord-291950-9gtsqyfj	175	24	towards	towards	IN
cord-291950-9gtsqyfj	175	25	non	non	JJ
cord-291950-9gtsqyfj	175	26	-	-	JJ
cord-291950-9gtsqyfj	175	27	Lys48-linked	lys48-linked	JJ
cord-291950-9gtsqyfj	175	28	polyubiquitin	polyubiquitin	NNP
cord-291950-9gtsqyfj	175	29	chains	chain	NNS
cord-291950-9gtsqyfj	175	30	[	[	-LRB-
cord-291950-9gtsqyfj	175	31	20	20	CD
cord-291950-9gtsqyfj	175	32	]	]	-RRB-
cord-291950-9gtsqyfj	175	33	.	.	.
cord-291950-9gtsqyfj	176	1	The	the	DT
cord-291950-9gtsqyfj	176	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	176	3	structure	structure	NN
cord-291950-9gtsqyfj	176	4	has	have	VBZ
cord-291950-9gtsqyfj	176	5	been	be	VBN
cord-291950-9gtsqyfj	176	6	solved	solve	VBN
cord-291950-9gtsqyfj	176	7	[	[	-LRB-
cord-291950-9gtsqyfj	176	8	21	21	CD
cord-291950-9gtsqyfj	176	9	]	]	-RRB-
cord-291950-9gtsqyfj	176	10	.	.	.
cord-291950-9gtsqyfj	177	1	Family	Family	NNP
cord-291950-9gtsqyfj	177	2	C85	C85	NNP
cord-291950-9gtsqyfj	177	3	includes	include	VBZ
cord-291950-9gtsqyfj	177	4	the	the	DT
cord-291950-9gtsqyfj	177	5	DUBA	DUBA	NNP
cord-291950-9gtsqyfj	177	6	deubiquitinylating	deubiquitinylate	VBG
cord-291950-9gtsqyfj	177	7	peptidase	peptidase	NN
cord-291950-9gtsqyfj	177	8	,	,	,
cord-291950-9gtsqyfj	177	9	which	which	WDT
cord-291950-9gtsqyfj	177	10	has	have	VBZ
cord-291950-9gtsqyfj	177	11	been	be	VBN
cord-291950-9gtsqyfj	177	12	shown	show	VBN
cord-291950-9gtsqyfj	177	13	to	to	TO
cord-291950-9gtsqyfj	177	14	cleave	cleave	VB
cord-291950-9gtsqyfj	177	15	the	the	DT
cord-291950-9gtsqyfj	177	16	lysine-63-linked	lysine-63-linked	NNP
cord-291950-9gtsqyfj	177	17	polyubiquitin	polyubiquitin	NNS
cord-291950-9gtsqyfj	177	18	chains	chain	NNS
cord-291950-9gtsqyfj	177	19	on	on	IN
cord-291950-9gtsqyfj	177	20	tumor	tumor	NN
cord-291950-9gtsqyfj	177	21	necrosis	necrosis	NN
cord-291950-9gtsqyfj	177	22	factor	factor	NN
cord-291950-9gtsqyfj	177	23	receptor	receptor	NN
cord-291950-9gtsqyfj	177	24	-	-	HYPH
cord-291950-9gtsqyfj	177	25	associated	associate	VBN
cord-291950-9gtsqyfj	177	26	factor	factor	NN
cord-291950-9gtsqyfj	177	27	3	3	CD
cord-291950-9gtsqyfj	177	28	[	[	-LRB-
cord-291950-9gtsqyfj	177	29	22	22	CD
cord-291950-9gtsqyfj	177	30	]	]	-RRB-
cord-291950-9gtsqyfj	177	31	.	.	.
cord-291950-9gtsqyfj	178	1	However	however	RB
cord-291950-9gtsqyfj	178	2	,	,	,
cord-291950-9gtsqyfj	178	3	no	no	DT
cord-291950-9gtsqyfj	178	4	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	178	5	structure	structure	NN
cord-291950-9gtsqyfj	178	6	has	have	VBZ
cord-291950-9gtsqyfj	178	7	been	be	VBN
cord-291950-9gtsqyfj	178	8	solved	solve	VBN
cord-291950-9gtsqyfj	178	9	for	for	IN
cord-291950-9gtsqyfj	178	10	any	any	DT
cord-291950-9gtsqyfj	178	11	member	member	NN
cord-291950-9gtsqyfj	178	12	of	of	IN
cord-291950-9gtsqyfj	178	13	the	the	DT
cord-291950-9gtsqyfj	178	14	family	family	NN
cord-291950-9gtsqyfj	178	15	,	,	,
cord-291950-9gtsqyfj	178	16	and	and	CC
cord-291950-9gtsqyfj	178	17	the	the	DT
cord-291950-9gtsqyfj	178	18	active	active	JJ
cord-291950-9gtsqyfj	178	19	site	site	NN
cord-291950-9gtsqyfj	178	20	residues	residue	NNS
cord-291950-9gtsqyfj	178	21	are	be	VBP
cord-291950-9gtsqyfj	178	22	predictions	prediction	NNS
cord-291950-9gtsqyfj	178	23	only	only	RB
cord-291950-9gtsqyfj	178	24	[	[	-LRB-
cord-291950-9gtsqyfj	178	25	15	15	CD
cord-291950-9gtsqyfj	178	26	]	]	-RRB-
cord-291950-9gtsqyfj	178	27	.	.	.
cord-291950-9gtsqyfj	179	1	Ataxin-3	Ataxin-3	NNP
cord-291950-9gtsqyfj	180	1	(	(	-LRB-
cord-291950-9gtsqyfj	180	2	Chapter	chapter	NN
cord-291950-9gtsqyfj	180	3	479	479	CD
cord-291950-9gtsqyfj	180	4	)	)	-RRB-
cord-291950-9gtsqyfj	180	5	is	be	VBZ
cord-291950-9gtsqyfj	180	6	yet	yet	RB
cord-291950-9gtsqyfj	180	7	another	another	DT
cord-291950-9gtsqyfj	180	8	deubiquitinating	deubiquitinating	NN
cord-291950-9gtsqyfj	180	9	enzyme	enzyme	NN
cord-291950-9gtsqyfj	180	10	and	and	CC
cord-291950-9gtsqyfj	180	11	a	a	DT
cord-291950-9gtsqyfj	180	12	member	member	NN
cord-291950-9gtsqyfj	180	13	of	of	IN
cord-291950-9gtsqyfj	180	14	family	family	NN
cord-291950-9gtsqyfj	180	15	C86	C86	NNP
cord-291950-9gtsqyfj	180	16	.	.	.
cord-291950-9gtsqyfj	181	1	The	the	DT
cord-291950-9gtsqyfj	181	2	nuclear	nuclear	JJ
cord-291950-9gtsqyfj	181	3	magnetic	magnetic	JJ
cord-291950-9gtsqyfj	181	4	resonance	resonance	NN
cord-291950-9gtsqyfj	181	5	solution	solution	NN
cord-291950-9gtsqyfj	181	6	structure	structure	NN
cord-291950-9gtsqyfj	181	7	of	of	IN
cord-291950-9gtsqyfj	181	8	the	the	DT
cord-291950-9gtsqyfj	181	9	domain	domain	NN
cord-291950-9gtsqyfj	181	10	containing	contain	VBG
cord-291950-9gtsqyfj	181	11	the	the	DT
cord-291950-9gtsqyfj	181	12	active	active	JJ
cord-291950-9gtsqyfj	181	13	site	site	NN
cord-291950-9gtsqyfj	181	14	of	of	IN
cord-291950-9gtsqyfj	181	15	ataxin-3	ataxin-3	NNP
cord-291950-9gtsqyfj	181	16	,	,	,
cord-291950-9gtsqyfj	181	17	known	know	VBN
cord-291950-9gtsqyfj	181	18	as	as	IN
cord-291950-9gtsqyfj	181	19	the	the	DT
cord-291950-9gtsqyfj	181	20	Josephin	Josephin	NNP
cord-291950-9gtsqyfj	181	21	domain	domain	NN
cord-291950-9gtsqyfj	181	22	,	,	,
cord-291950-9gtsqyfj	181	23	has	have	VBZ
cord-291950-9gtsqyfj	181	24	been	be	VBN
cord-291950-9gtsqyfj	181	25	determined	determine	VBN
cord-291950-9gtsqyfj	181	26	[	[	-LRB-
cord-291950-9gtsqyfj	181	27	23	23	CD
cord-291950-9gtsqyfj	181	28	]	]	-RRB-
cord-291950-9gtsqyfj	181	29	,	,	,
cord-291950-9gtsqyfj	181	30	and	and	CC
cord-291950-9gtsqyfj	181	31	shows	show	VBZ
cord-291950-9gtsqyfj	181	32	the	the	DT
cord-291950-9gtsqyfj	181	33	characteristics	characteristic	NNS
cord-291950-9gtsqyfj	181	34	of	of	IN
cord-291950-9gtsqyfj	181	35	a	a	DT
cord-291950-9gtsqyfj	181	36	cysteine	cysteine	JJ
cord-291950-9gtsqyfj	181	37	peptidase	peptidase	NN
cord-291950-9gtsqyfj	181	38	in	in	IN
cord-291950-9gtsqyfj	181	39	clan	clan	NN
cord-291950-9gtsqyfj	181	40	CA	CA	NNP
cord-291950-9gtsqyfj	181	41	.	.	.
cord-291950-9gtsqyfj	182	1	Family	Family	NNP
cord-291950-9gtsqyfj	182	2	C88	C88	NNP
cord-291950-9gtsqyfj	182	3	includes	include	VBZ
cord-291950-9gtsqyfj	182	4	OTU1	OTU1	NNP
cord-291950-9gtsqyfj	182	5	peptidase	peptidase	NN
cord-291950-9gtsqyfj	182	6	from	from	IN
cord-291950-9gtsqyfj	182	7	Saccharomyces	Saccharomyces	NNP
cord-291950-9gtsqyfj	182	8	cerevisiae	cerevisiae	NNS
cord-291950-9gtsqyfj	182	9	(	(	-LRB-
cord-291950-9gtsqyfj	182	10	Chapter	chapter	NN
cord-291950-9gtsqyfj	182	11	478	478	CD
cord-291950-9gtsqyfj	182	12	)	)	-RRB-
cord-291950-9gtsqyfj	182	13	which	which	WDT
cord-291950-9gtsqyfj	182	14	preferentially	preferentially	RB
cord-291950-9gtsqyfj	182	15	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	182	16	longer	long	JJR
cord-291950-9gtsqyfj	182	17	polyubiquitin	polyubiquitin	VBZ
cord-291950-9gtsqyfj	182	18	chains	chain	NNS
cord-291950-9gtsqyfj	182	19	with	with	IN
cord-291950-9gtsqyfj	182	20	Lys48	lys48	JJ
cord-291950-9gtsqyfj	182	21	linkages	linkage	NNS
cord-291950-9gtsqyfj	182	22	.	.	.
cord-291950-9gtsqyfj	183	1	The	the	DT
cord-291950-9gtsqyfj	183	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	183	3	structure	structure	NN
cord-291950-9gtsqyfj	183	4	has	have	VBZ
cord-291950-9gtsqyfj	183	5	been	be	VBN
cord-291950-9gtsqyfj	183	6	solved	solve	VBN
cord-291950-9gtsqyfj	183	7	for	for	IN
cord-291950-9gtsqyfj	183	8	the	the	DT
cord-291950-9gtsqyfj	183	9	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	183	10	domain	domain	NN
cord-291950-9gtsqyfj	183	11	,	,	,
cord-291950-9gtsqyfj	183	12	and	and	CC
cord-291950-9gtsqyfj	183	13	the	the	DT
cord-291950-9gtsqyfj	183	14	structure	structure	NN
cord-291950-9gtsqyfj	183	15	is	be	VBZ
cord-291950-9gtsqyfj	183	16	similar	similar	JJ
cord-291950-9gtsqyfj	183	17	to	to	IN
cord-291950-9gtsqyfj	183	18	that	that	DT
cord-291950-9gtsqyfj	183	19	of	of	IN
cord-291950-9gtsqyfj	183	20	other	other	JJ
cord-291950-9gtsqyfj	183	21	clan	clan	NN
cord-291950-9gtsqyfj	183	22	CA	CA	NNP
cord-291950-9gtsqyfj	183	23	members	member	NNS
cord-291950-9gtsqyfj	183	24	[	[	-LRB-
cord-291950-9gtsqyfj	183	25	24	24	CD
cord-291950-9gtsqyfj	183	26	]	]	-RRB-
cord-291950-9gtsqyfj	183	27	.	.	.
cord-291950-9gtsqyfj	184	1	Surprisingly	surprisingly	RB
cord-291950-9gtsqyfj	184	2	,	,	,
cord-291950-9gtsqyfj	184	3	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	184	4	that	that	WDT
cord-291950-9gtsqyfj	184	5	releases	release	VBZ
cord-291950-9gtsqyfj	184	6	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	184	7	from	from	IN
cord-291950-9gtsqyfj	184	8	proteins	protein	NNS
cord-291950-9gtsqyfj	184	9	have	have	VBP
cord-291950-9gtsqyfj	184	10	been	be	VBN
cord-291950-9gtsqyfj	184	11	discovered	discover	VBN
cord-291950-9gtsqyfj	184	12	in	in	IN
cord-291950-9gtsqyfj	184	13	viruses	virus	NNS
cord-291950-9gtsqyfj	184	14	.	.	.
cord-291950-9gtsqyfj	185	1	The	the	DT
cord-291950-9gtsqyfj	185	2	UL36	UL36	NNP
cord-291950-9gtsqyfj	185	3	protein	protein	NN
cord-291950-9gtsqyfj	185	4	from	from	IN
cord-291950-9gtsqyfj	185	5	herpes	herpes	NNP
cord-291950-9gtsqyfj	185	6	simplex	simplex	NNP
cord-291950-9gtsqyfj	185	7	virus	virus	NN
cord-291950-9gtsqyfj	185	8	releases	release	VBZ
cord-291950-9gtsqyfj	185	9	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	185	10	from	from	IN
cord-291950-9gtsqyfj	185	11	proteins	protein	NNS
cord-291950-9gtsqyfj	185	12	ubiquitinylated	ubiquitinylate	VBN
cord-291950-9gtsqyfj	185	13	via	via	IN
cord-291950-9gtsqyfj	185	14	Lys48	Lys48	NNP
cord-291950-9gtsqyfj	185	15	and	and	CC
cord-291950-9gtsqyfj	185	16	is	be	VBZ
cord-291950-9gtsqyfj	185	17	the	the	DT
cord-291950-9gtsqyfj	185	18	founder	founder	NN
cord-291950-9gtsqyfj	185	19	of	of	IN
cord-291950-9gtsqyfj	185	20	family	family	NN
cord-291950-9gtsqyfj	185	21	C76	C76	NNP
cord-291950-9gtsqyfj	185	22	(	(	-LRB-
cord-291950-9gtsqyfj	185	23	Chapter	chapter	NN
cord-291950-9gtsqyfj	185	24	480	480	CD
cord-291950-9gtsqyfj	185	25	)	)	-RRB-
cord-291950-9gtsqyfj	185	26	.	.	.
cord-291950-9gtsqyfj	186	1	The	the	DT
cord-291950-9gtsqyfj	186	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	186	3	structure	structure	NN
cord-291950-9gtsqyfj	186	4	has	have	VBZ
cord-291950-9gtsqyfj	186	5	been	be	VBN
cord-291950-9gtsqyfj	186	6	solved	solve	VBN
cord-291950-9gtsqyfj	186	7	,	,	,
cord-291950-9gtsqyfj	186	8	and	and	CC
cord-291950-9gtsqyfj	186	9	shows	show	VBZ
cord-291950-9gtsqyfj	186	10	a	a	DT
cord-291950-9gtsqyfj	186	11	papain	papain	NN
cord-291950-9gtsqyfj	186	12	-	-	HYPH
cord-291950-9gtsqyfj	186	13	like	like	IN
cord-291950-9gtsqyfj	186	14	fold	fold	VB
cord-291950-9gtsqyfj	186	15	[	[	-LRB-
cord-291950-9gtsqyfj	186	16	25	25	CD
cord-291950-9gtsqyfj	186	17	]	]	-RRB-
cord-291950-9gtsqyfj	186	18	.	.	.
cord-291950-9gtsqyfj	187	1	The	the	DT
cord-291950-9gtsqyfj	187	2	Crimean	Crimean	NNP
cord-291950-9gtsqyfj	187	3	-	-	HYPH
cord-291950-9gtsqyfj	187	4	Congo	Congo	NNP
cord-291950-9gtsqyfj	187	5	hemorrhagic	hemorrhagic	JJ
cord-291950-9gtsqyfj	187	6	fever	fever	NN
cord-291950-9gtsqyfj	187	7	virus	virus	NN
cord-291950-9gtsqyfj	187	8	(	(	-LRB-
cord-291950-9gtsqyfj	187	9	a	a	DT
cord-291950-9gtsqyfj	187	10	Nairovirus	Nairovirus	NNP
cord-291950-9gtsqyfj	187	11	)	)	-RRB-
cord-291950-9gtsqyfj	187	12	also	also	RB
cord-291950-9gtsqyfj	187	13	possesses	possess	VBZ
cord-291950-9gtsqyfj	187	14	a	a	DT
cord-291950-9gtsqyfj	187	15	deubiquitinating	deubiquitinating	NN
cord-291950-9gtsqyfj	187	16	enzyme	enzyme	NN
cord-291950-9gtsqyfj	187	17	which	which	WDT
cord-291950-9gtsqyfj	187	18	can	can	MD
cord-291950-9gtsqyfj	187	19	downregulate	downregulate	VB
cord-291950-9gtsqyfj	187	20	antiviral	antiviral	JJ
cord-291950-9gtsqyfj	187	21	responses	response	NNS
cord-291950-9gtsqyfj	187	22	of	of	IN
cord-291950-9gtsqyfj	187	23	the	the	DT
cord-291950-9gtsqyfj	187	24	host	host	NN
cord-291950-9gtsqyfj	187	25	by	by	IN
cord-291950-9gtsqyfj	187	26	release	release	NN
cord-291950-9gtsqyfj	187	27	of	of	IN
cord-291950-9gtsqyfj	187	28	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	187	29	and	and	CC
cord-291950-9gtsqyfj	187	30	interferon	interferon	NN
cord-291950-9gtsqyfj	187	31	-	-	HYPH
cord-291950-9gtsqyfj	187	32	stimulated	stimulate	VBN
cord-291950-9gtsqyfj	187	33	gene	gene	NN
cord-291950-9gtsqyfj	187	34	product	product	NN
cord-291950-9gtsqyfj	187	35	15	15	CD
cord-291950-9gtsqyfj	187	36	from	from	IN
cord-291950-9gtsqyfj	187	37	proteins	protein	NNS
cord-291950-9gtsqyfj	187	38	of	of	IN
cord-291950-9gtsqyfj	187	39	the	the	DT
cord-291950-9gtsqyfj	187	40	antiviral	antiviral	JJ
cord-291950-9gtsqyfj	187	41	and	and	CC
cord-291950-9gtsqyfj	187	42	inflammatory	inflammatory	JJ
cord-291950-9gtsqyfj	187	43	pathways	pathway	NNS
cord-291950-9gtsqyfj	187	44	[	[	-LRB-
cord-291950-9gtsqyfj	187	45	26	26	CD
cord-291950-9gtsqyfj	187	46	]	]	-RRB-
cord-291950-9gtsqyfj	187	47	.	.	.
cord-291950-9gtsqyfj	188	1	The	the	DT
cord-291950-9gtsqyfj	188	2	Nairovirus	Nairovirus	NNP
cord-291950-9gtsqyfj	188	3	enzyme	enzyme	NN
cord-291950-9gtsqyfj	188	4	is	be	VBZ
cord-291950-9gtsqyfj	188	5	a	a	DT
cord-291950-9gtsqyfj	188	6	member	member	NN
cord-291950-9gtsqyfj	188	7	of	of	IN
cord-291950-9gtsqyfj	188	8	family	family	NN
cord-291950-9gtsqyfj	188	9	C87	C87	NNP
cord-291950-9gtsqyfj	188	10	,	,	,
cord-291950-9gtsqyfj	188	11	and	and	CC
cord-291950-9gtsqyfj	188	12	the	the	DT
cord-291950-9gtsqyfj	188	13	order	order	NN
cord-291950-9gtsqyfj	188	14	of	of	IN
cord-291950-9gtsqyfj	188	15	active	active	JJ
cord-291950-9gtsqyfj	188	16	site	site	NN
cord-291950-9gtsqyfj	188	17	residues	residue	NNS
cord-291950-9gtsqyfj	188	18	,	,	,
cord-291950-9gtsqyfj	188	19	identified	identify	VBN
cord-291950-9gtsqyfj	188	20	by	by	IN
cord-291950-9gtsqyfj	188	21	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	188	22	[	[	-LRB-
cord-291950-9gtsqyfj	188	23	26	26	CD
cord-291950-9gtsqyfj	188	24	]	]	-RRB-
cord-291950-9gtsqyfj	188	25	,	,	,
cord-291950-9gtsqyfj	188	26	led	lead	VBD
cord-291950-9gtsqyfj	188	27	us	-PRON-	PRP
cord-291950-9gtsqyfj	188	28	to	to	TO
cord-291950-9gtsqyfj	188	29	include	include	VB
cord-291950-9gtsqyfj	188	30	the	the	DT
cord-291950-9gtsqyfj	188	31	family	family	NN
cord-291950-9gtsqyfj	188	32	in	in	IN
cord-291950-9gtsqyfj	188	33	clan	clan	NN
cord-291950-9gtsqyfj	188	34	CA	CA	NNP
cord-291950-9gtsqyfj	188	35	.	.	.
cord-291950-9gtsqyfj	189	1	Other	other	JJ
cord-291950-9gtsqyfj	189	2	proteins	protein	NNS
cord-291950-9gtsqyfj	189	3	act	act	VBP
cord-291950-9gtsqyfj	189	4	like	like	IN
cord-291950-9gtsqyfj	189	5	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	189	6	and	and	CC
cord-291950-9gtsqyfj	189	7	can	can	MD
cord-291950-9gtsqyfj	189	8	be	be	VB
cord-291950-9gtsqyfj	189	9	tagged	tag	VBN
cord-291950-9gtsqyfj	189	10	to	to	IN
cord-291950-9gtsqyfj	189	11	proteins	protein	NNS
cord-291950-9gtsqyfj	190	1	,	,	,
cord-291950-9gtsqyfj	190	2	these	these	DT
cord-291950-9gtsqyfj	190	3	include	include	VBP
cord-291950-9gtsqyfj	190	4	SUMO	SUMO	NNP
cord-291950-9gtsqyfj	190	5	and	and	CC
cord-291950-9gtsqyfj	190	6	NEDD-8	NEDD-8	NNP
cord-291950-9gtsqyfj	190	7	.	.	.
cord-291950-9gtsqyfj	191	1	Ubiquitin	Ubiquitin	NNP
cord-291950-9gtsqyfj	191	2	-	-	HYPH
cord-291950-9gtsqyfj	191	3	fold	fold	VB
cord-291950-9gtsqyfj	191	4	modifier-1	modifier-1	NNP
cord-291950-9gtsqyfj	192	1	(	(	-LRB-
cord-291950-9gtsqyfj	192	2	Ufm1	Ufm1	NNP
cord-291950-9gtsqyfj	192	3	)	)	-RRB-
cord-291950-9gtsqyfj	192	4	is	be	VBZ
cord-291950-9gtsqyfj	192	5	another	another	DT
cord-291950-9gtsqyfj	192	6	ubiquitinlike	ubiquitinlike	JJ
cord-291950-9gtsqyfj	192	7	protein	protein	NN
cord-291950-9gtsqyfj	192	8	,	,	,
cord-291950-9gtsqyfj	192	9	and	and	CC
cord-291950-9gtsqyfj	192	10	like	like	IN
cord-291950-9gtsqyfj	192	11	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	192	12	attaches	attach	VBZ
cord-291950-9gtsqyfj	192	13	to	to	IN
cord-291950-9gtsqyfj	192	14	proteins	protein	NNS
cord-291950-9gtsqyfj	192	15	via	via	IN
cord-291950-9gtsqyfj	192	16	the	the	DT
cord-291950-9gtsqyfj	192	17	C	C	NNP
cord-291950-9gtsqyfj	192	18	-	-	HYPH
cord-291950-9gtsqyfj	192	19	terminal	terminal	NN
cord-291950-9gtsqyfj	192	20	glycine	glycine	NN
cord-291950-9gtsqyfj	192	21	.	.	.
cord-291950-9gtsqyfj	193	1	The	the	DT
cord-291950-9gtsqyfj	193	2	physiological	physiological	JJ
cord-291950-9gtsqyfj	193	3	relevance	relevance	NN
cord-291950-9gtsqyfj	193	4	for	for	IN
cord-291950-9gtsqyfj	193	5	tagging	tag	VBG
cord-291950-9gtsqyfj	193	6	proteins	protein	NNS
cord-291950-9gtsqyfj	193	7	with	with	IN
cord-291950-9gtsqyfj	193	8	Ufm1	Ufm1	NNP
cord-291950-9gtsqyfj	193	9	is	be	VBZ
cord-291950-9gtsqyfj	193	10	unknown	unknown	JJ
cord-291950-9gtsqyfj	193	11	,	,	,
cord-291950-9gtsqyfj	193	12	but	but	CC
cord-291950-9gtsqyfj	193	13	tagged	tag	VBN
cord-291950-9gtsqyfj	193	14	proteins	protein	NNS
cord-291950-9gtsqyfj	193	15	are	be	VBP
cord-291950-9gtsqyfj	193	16	not	not	RB
cord-291950-9gtsqyfj	193	17	degraded	degrade	VBN
cord-291950-9gtsqyfj	193	18	.	.	.
cord-291950-9gtsqyfj	194	1	Peptidases	peptidase	NNS
cord-291950-9gtsqyfj	194	2	in	in	IN
cord-291950-9gtsqyfj	194	3	family	family	NN
cord-291950-9gtsqyfj	194	4	C78	C78	NNP
cord-291950-9gtsqyfj	194	5	,	,	,
cord-291950-9gtsqyfj	194	6	which	which	WDT
cord-291950-9gtsqyfj	194	7	includes	include	VBZ
cord-291950-9gtsqyfj	194	8	UfSP1	UfSP1	NNP
cord-291950-9gtsqyfj	194	9	peptidase	peptidase	NN
cord-291950-9gtsqyfj	194	10	(	(	-LRB-
cord-291950-9gtsqyfj	194	11	Chapter	chapter	NN
cord-291950-9gtsqyfj	194	12	481	481	CD
cord-291950-9gtsqyfj	194	13	)	)	-RRB-
cord-291950-9gtsqyfj	194	14	,	,	,
cord-291950-9gtsqyfj	194	15	release	release	VB
cord-291950-9gtsqyfj	194	16	Ufm1	Ufm1	NNP
cord-291950-9gtsqyfj	194	17	from	from	IN
cord-291950-9gtsqyfj	194	18	conjugates	conjugate	NNS
cord-291950-9gtsqyfj	194	19	and	and	CC
cord-291950-9gtsqyfj	194	20	process	process	VB
cord-291950-9gtsqyfj	194	21	the	the	DT
cord-291950-9gtsqyfj	194	22	Ufm1	Ufm1	NNP
cord-291950-9gtsqyfj	194	23	precursor	precursor	NN
cord-291950-9gtsqyfj	194	24	by	by	IN
cord-291950-9gtsqyfj	194	25	removing	remove	VBG
cord-291950-9gtsqyfj	194	26	a	a	DT
cord-291950-9gtsqyfj	194	27	C	c	NN
cord-291950-9gtsqyfj	194	28	-	-	HYPH
cord-291950-9gtsqyfj	194	29	terminal	terminal	NN
cord-291950-9gtsqyfj	194	30	dipeptide	dipeptide	NN
cord-291950-9gtsqyfj	194	31	[	[	-LRB-
cord-291950-9gtsqyfj	194	32	27	27	CD
cord-291950-9gtsqyfj	194	33	]	]	-RRB-
cord-291950-9gtsqyfj	194	34	.	.	.
cord-291950-9gtsqyfj	195	1	Once	once	RB
cord-291950-9gtsqyfj	195	2	again	again	RB
cord-291950-9gtsqyfj	195	3	,	,	,
cord-291950-9gtsqyfj	195	4	resolution	resolution	NN
cord-291950-9gtsqyfj	195	5	of	of	IN
cord-291950-9gtsqyfj	195	6	the	the	DT
cord-291950-9gtsqyfj	195	7	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	195	8	structure	structure	NN
cord-291950-9gtsqyfj	195	9	has	have	VBZ
cord-291950-9gtsqyfj	195	10	confirmed	confirm	VBN
cord-291950-9gtsqyfj	195	11	the	the	DT
cord-291950-9gtsqyfj	195	12	relationship	relationship	NN
cord-291950-9gtsqyfj	195	13	to	to	IN
cord-291950-9gtsqyfj	195	14	papain	papain	NN
cord-291950-9gtsqyfj	195	15	[	[	-LRB-
cord-291950-9gtsqyfj	195	16	28	28	CD
cord-291950-9gtsqyfj	195	17	]	]	-RRB-
cord-291950-9gtsqyfj	195	18	and	and	CC
cord-291950-9gtsqyfj	195	19	the	the	DT
cord-291950-9gtsqyfj	195	20	family	family	NN
cord-291950-9gtsqyfj	195	21	C78	C78	NNP
cord-291950-9gtsqyfj	195	22	is	be	VBZ
cord-291950-9gtsqyfj	195	23	included	include	VBN
cord-291950-9gtsqyfj	195	24	in	in	IN
cord-291950-9gtsqyfj	195	25	clan	clan	NN
cord-291950-9gtsqyfj	195	26	CA	CA	NNP
cord-291950-9gtsqyfj	195	27	.	.	.
cord-291950-9gtsqyfj	196	1	The	the	DT
cord-291950-9gtsqyfj	196	2	aspartic	aspartic	JJ
cord-291950-9gtsqyfj	196	3	acid	acid	NN
cord-291950-9gtsqyfj	196	4	that	that	WDT
cord-291950-9gtsqyfj	196	5	is	be	VBZ
cord-291950-9gtsqyfj	196	6	the	the	DT
cord-291950-9gtsqyfj	196	7	third	third	JJ
cord-291950-9gtsqyfj	196	8	member	member	NN
cord-291950-9gtsqyfj	196	9	of	of	IN
cord-291950-9gtsqyfj	196	10	the	the	DT
cord-291950-9gtsqyfj	196	11	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	196	12	triad	triad	NN
cord-291950-9gtsqyfj	196	13	unusually	unusually	RB
cord-291950-9gtsqyfj	196	14	is	be	VBZ
cord-291950-9gtsqyfj	196	15	N	n	CD
cord-291950-9gtsqyfj	196	16	-	-	HYPH
cord-291950-9gtsqyfj	196	17	terminal	terminal	NN
cord-291950-9gtsqyfj	196	18	of	of	IN
cord-291950-9gtsqyfj	196	19	the	the	DT
cord-291950-9gtsqyfj	196	20	histidine	histidine	NN
cord-291950-9gtsqyfj	196	21	,	,	,
cord-291950-9gtsqyfj	196	22	whereas	whereas	IN
cord-291950-9gtsqyfj	196	23	in	in	IN
cord-291950-9gtsqyfj	196	24	most	most	JJS
cord-291950-9gtsqyfj	196	25	papain	papain	NN
cord-291950-9gtsqyfj	196	26	-	-	HYPH
cord-291950-9gtsqyfj	196	27	like	like	JJ
cord-291950-9gtsqyfj	196	28	proteins	protein	NNS
cord-291950-9gtsqyfj	196	29	follows	follow	VBZ
cord-291950-9gtsqyfj	196	30	the	the	DT
cord-291950-9gtsqyfj	196	31	histidine	histidine	NN
cord-291950-9gtsqyfj	196	32	.	.	.
cord-291950-9gtsqyfj	197	1	The	the	DT
cord-291950-9gtsqyfj	197	2	residue	residue	NN
cord-291950-9gtsqyfj	197	3	stabilizing	stabilize	VBG
cord-291950-9gtsqyfj	197	4	the	the	DT
cord-291950-9gtsqyfj	197	5	oxyanion	oxyanion	NN
cord-291950-9gtsqyfj	197	6	hole	hole	NN
cord-291950-9gtsqyfj	197	7	is	be	VBZ
cord-291950-9gtsqyfj	197	8	a	a	DT
cord-291950-9gtsqyfj	197	9	tyrosine	tyrosine	NN
cord-291950-9gtsqyfj	197	10	(	(	-LRB-
cord-291950-9gtsqyfj	197	11	whereas	whereas	IN
cord-291950-9gtsqyfj	197	12	it	-PRON-	PRP
cord-291950-9gtsqyfj	197	13	is	be	VBZ
cord-291950-9gtsqyfj	197	14	glutamine	glutamine	NN
cord-291950-9gtsqyfj	197	15	in	in	IN
cord-291950-9gtsqyfj	197	16	papain	papain	NN
cord-291950-9gtsqyfj	197	17	)	)	-RRB-
cord-291950-9gtsqyfj	197	18	.	.	.
cord-291950-9gtsqyfj	198	1	In	in	IN
cord-291950-9gtsqyfj	198	2	both	both	PDT
cord-291950-9gtsqyfj	198	3	these	these	DT
cord-291950-9gtsqyfj	198	4	respects	respect	NNS
cord-291950-9gtsqyfj	198	5	,	,	,
cord-291950-9gtsqyfj	198	6	members	member	NNS
cord-291950-9gtsqyfj	198	7	of	of	IN
cord-291950-9gtsqyfj	198	8	family	family	NN
cord-291950-9gtsqyfj	198	9	C78	C78	NNP
cord-291950-9gtsqyfj	198	10	resemble	resemble	VBP
cord-291950-9gtsqyfj	198	11	members	member	NNS
cord-291950-9gtsqyfj	198	12	of	of	IN
cord-291950-9gtsqyfj	198	13	the	the	DT
cord-291950-9gtsqyfj	198	14	family	family	NN
cord-291950-9gtsqyfj	198	15	C54	C54	NNP
cord-291950-9gtsqyfj	198	16	.	.	.
cord-291950-9gtsqyfj	199	1	Family	Family	NNP
cord-291950-9gtsqyfj	199	2	C54	C54	NNP
cord-291950-9gtsqyfj	199	3	includes	include	VBZ
cord-291950-9gtsqyfj	199	4	the	the	DT
cord-291950-9gtsqyfj	199	5	yeast	yeast	NN
cord-291950-9gtsqyfj	199	6	peptidase	peptidase	NN
cord-291950-9gtsqyfj	199	7	Aut2	Aut2	NNP
cord-291950-9gtsqyfj	199	8	that	that	WDT
cord-291950-9gtsqyfj	199	9	is	be	VBZ
cord-291950-9gtsqyfj	199	10	responsible	responsible	JJ
cord-291950-9gtsqyfj	199	11	for	for	IN
cord-291950-9gtsqyfj	199	12	the	the	DT
cord-291950-9gtsqyfj	199	13	removal	removal	NN
cord-291950-9gtsqyfj	199	14	of	of	IN
cord-291950-9gtsqyfj	199	15	a	a	DT
cord-291950-9gtsqyfj	199	16	C	c	NN
cord-291950-9gtsqyfj	199	17	-	-	HYPH
cord-291950-9gtsqyfj	199	18	terminal	terminal	NN
cord-291950-9gtsqyfj	199	19	arginine	arginine	NN
cord-291950-9gtsqyfj	199	20	residue	residue	NN
cord-291950-9gtsqyfj	199	21	from	from	IN
cord-291950-9gtsqyfj	199	22	the	the	DT
cord-291950-9gtsqyfj	199	23	Apg8	apg8	NN
cord-291950-9gtsqyfj	199	24	(	(	-LRB-
cord-291950-9gtsqyfj	199	25	or	or	CC
cord-291950-9gtsqyfj	199	26	Aut7	Aut7	NNP
cord-291950-9gtsqyfj	199	27	)	)	-RRB-
cord-291950-9gtsqyfj	199	28	protein	protein	NN
cord-291950-9gtsqyfj	199	29	.	.	.
cord-291950-9gtsqyfj	200	1	The	the	DT
cord-291950-9gtsqyfj	200	2	Apg8FG	Apg8FG	NNP
cord-291950-9gtsqyfj	200	3	protein	protein	NN
cord-291950-9gtsqyfj	200	4	,	,	,
cord-291950-9gtsqyfj	200	5	as	as	IN
cord-291950-9gtsqyfj	200	6	the	the	DT
cord-291950-9gtsqyfj	200	7	processed	process	VBN
cord-291950-9gtsqyfj	200	8	substrate	substrate	NN
cord-291950-9gtsqyfj	200	9	is	be	VBZ
cord-291950-9gtsqyfj	200	10	known	know	VBN
cord-291950-9gtsqyfj	200	11	,	,	,
cord-291950-9gtsqyfj	200	12	is	be	VBZ
cord-291950-9gtsqyfj	200	13	then	then	RB
cord-291950-9gtsqyfj	200	14	able	able	JJ
cord-291950-9gtsqyfj	200	15	to	to	TO
cord-291950-9gtsqyfj	200	16	form	form	VB
cord-291950-9gtsqyfj	200	17	a	a	DT
cord-291950-9gtsqyfj	200	18	conjugate	conjugate	NN
cord-291950-9gtsqyfj	200	19	with	with	IN
cord-291950-9gtsqyfj	200	20	an	an	DT
cord-291950-9gtsqyfj	200	21	unidentified	unidentified	JJ
cord-291950-9gtsqyfj	200	22	protein	protein	NN
cord-291950-9gtsqyfj	200	23	via	via	IN
cord-291950-9gtsqyfj	200	24	the	the	DT
cord-291950-9gtsqyfj	200	25	newly	newly	RB
cord-291950-9gtsqyfj	200	26	exposed	expose	VBN
cord-291950-9gtsqyfj	200	27	C	c	NN
cord-291950-9gtsqyfj	200	28	-	-	HYPH
cord-291950-9gtsqyfj	200	29	terminal	terminal	NN
cord-291950-9gtsqyfj	200	30	Gly	Gly	NNP
cord-291950-9gtsqyfj	200	31	and	and	CC
cord-291950-9gtsqyfj	200	32	the	the	DT
cord-291950-9gtsqyfj	200	33	conjugate	conjugate	NN
cord-291950-9gtsqyfj	200	34	binds	bind	VBZ
cord-291950-9gtsqyfj	200	35	tightly	tightly	RB
cord-291950-9gtsqyfj	200	36	to	to	IN
cord-291950-9gtsqyfj	200	37	membranes	membrane	NNS
cord-291950-9gtsqyfj	200	38	permitting	permit	VBG
cord-291950-9gtsqyfj	200	39	the	the	DT
cord-291950-9gtsqyfj	200	40	formation	formation	NN
cord-291950-9gtsqyfj	200	41	of	of	IN
cord-291950-9gtsqyfj	200	42	the	the	DT
cord-291950-9gtsqyfj	200	43	double	double	JJ
cord-291950-9gtsqyfj	200	44	-	-	HYPH
cord-291950-9gtsqyfj	200	45	membrane	membrane	NN
cord-291950-9gtsqyfj	200	46	vesicles	vesicle	NNS
cord-291950-9gtsqyfj	200	47	required	require	VBN
cord-291950-9gtsqyfj	200	48	for	for	IN
cord-291950-9gtsqyfj	200	49	the	the	DT
cord-291950-9gtsqyfj	200	50	transport	transport	NN
cord-291950-9gtsqyfj	200	51	of	of	IN
cord-291950-9gtsqyfj	200	52	material	material	NN
cord-291950-9gtsqyfj	200	53	from	from	IN
cord-291950-9gtsqyfj	200	54	the	the	DT
cord-291950-9gtsqyfj	200	55	cytoplasm	cytoplasm	NN
cord-291950-9gtsqyfj	200	56	to	to	IN
cord-291950-9gtsqyfj	200	57	an	an	DT
cord-291950-9gtsqyfj	200	58	autophagic	autophagic	NN
cord-291950-9gtsqyfj	200	59	vesicle	vesicle	NN
cord-291950-9gtsqyfj	200	60	.	.	.
cord-291950-9gtsqyfj	201	1	Homologs	Homologs	NNP
cord-291950-9gtsqyfj	201	2	are	be	VBP
cord-291950-9gtsqyfj	201	3	known	know	VBN
cord-291950-9gtsqyfj	201	4	from	from	IN
cord-291950-9gtsqyfj	201	5	human	human	JJ
cord-291950-9gtsqyfj	201	6	,	,	,
cord-291950-9gtsqyfj	201	7	mouse	mouse	NN
cord-291950-9gtsqyfj	201	8	,	,	,
cord-291950-9gtsqyfj	201	9	Drosophila	Drosophila	NNP
cord-291950-9gtsqyfj	201	10	melanogaster	melanogaster	NN
cord-291950-9gtsqyfj	201	11	,	,	,
cord-291950-9gtsqyfj	201	12	Caenorhabditis	Caenorhabditis	NNP
cord-291950-9gtsqyfj	201	13	elegans	elegan	NNS
cord-291950-9gtsqyfj	201	14	and	and	CC
cord-291950-9gtsqyfj	201	15	Arabidopsis	Arabidopsis	NNP
cord-291950-9gtsqyfj	201	16	thaliana	thaliana	NN
cord-291950-9gtsqyfj	201	17	.	.	.
cord-291950-9gtsqyfj	202	1	Inhibition	inhibition	NN
cord-291950-9gtsqyfj	202	2	by	by	IN
cord-291950-9gtsqyfj	202	3	N	N	NNP
cord-291950-9gtsqyfj	202	4	-	-	HYPH
cord-291950-9gtsqyfj	202	5	ethylmaleimide	ethylmaleimide	NN
cord-291950-9gtsqyfj	202	6	and	and	CC
cord-291950-9gtsqyfj	202	7	site	site	NN
cord-291950-9gtsqyfj	202	8	-	-	HYPH
cord-291950-9gtsqyfj	202	9	directed	direct	VBN
cord-291950-9gtsqyfj	202	10	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	202	11	of	of	IN
cord-291950-9gtsqyfj	202	12	Cys159	Cys159	.
cord-291950-9gtsqyfj	203	1	(	(	-LRB-
cord-291950-9gtsqyfj	203	2	see	see	VB
cord-291950-9gtsqyfj	203	3	Alignment	Alignment	NNP
cord-291950-9gtsqyfj	203	4	C54	C54	NNP
cord-291950-9gtsqyfj	203	5	in	in	IN
cord-291950-9gtsqyfj	203	6	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	203	7	)	)	-RRB-
cord-291950-9gtsqyfj	203	8	has	have	VBZ
cord-291950-9gtsqyfj	203	9	shown	show	VBN
cord-291950-9gtsqyfj	203	10	that	that	IN
cord-291950-9gtsqyfj	203	11	yeast	yeast	NN
cord-291950-9gtsqyfj	203	12	peptidase	peptidase	NN
cord-291950-9gtsqyfj	203	13	Aut2	Aut2	NNP
cord-291950-9gtsqyfj	203	14	is	be	VBZ
cord-291950-9gtsqyfj	203	15	a	a	DT
cord-291950-9gtsqyfj	203	16	cysteine	cysteine	NN
cord-291950-9gtsqyfj	203	17	peptidase	peptidase	NN
cord-291950-9gtsqyfj	203	18	(	(	-LRB-
cord-291950-9gtsqyfj	203	19	Chapter	chapter	NN
cord-291950-9gtsqyfj	203	20	482	482	CD
cord-291950-9gtsqyfj	203	21	)	)	-RRB-
cord-291950-9gtsqyfj	203	22	,	,	,
cord-291950-9gtsqyfj	203	23	but	but	CC
cord-291950-9gtsqyfj	203	24	other	other	JJ
cord-291950-9gtsqyfj	203	25	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	203	26	residues	residue	NNS
cord-291950-9gtsqyfj	203	27	have	have	VBP
cord-291950-9gtsqyfj	203	28	not	not	RB
cord-291950-9gtsqyfj	203	29	been	be	VBN
cord-291950-9gtsqyfj	203	30	determined	determine	VBN
cord-291950-9gtsqyfj	203	31	.	.	.
cord-291950-9gtsqyfj	204	1	The	the	DT
cord-291950-9gtsqyfj	204	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	204	3	structure	structure	NN
cord-291950-9gtsqyfj	204	4	of	of	IN
cord-291950-9gtsqyfj	204	5	human	human	JJ
cord-291950-9gtsqyfj	204	6	autophagin-1	autophagin-1	NNP
cord-291950-9gtsqyfj	204	7	has	have	VBZ
cord-291950-9gtsqyfj	204	8	been	be	VBN
cord-291950-9gtsqyfj	204	9	solved	solve	VBN
cord-291950-9gtsqyfj	204	10	[	[	-LRB-
cord-291950-9gtsqyfj	204	11	29	29	CD
cord-291950-9gtsqyfj	204	12	,	,	,
cord-291950-9gtsqyfj	204	13	30	30	CD
cord-291950-9gtsqyfj	204	14	]	]	-RRB-
cord-291950-9gtsqyfj	204	15	,	,	,
cord-291950-9gtsqyfj	204	16	and	and	CC
cord-291950-9gtsqyfj	204	17	shows	show	VBZ
cord-291950-9gtsqyfj	204	18	an	an	DT
cord-291950-9gtsqyfj	204	19	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	204	20	triad	triad	NN
cord-291950-9gtsqyfj	204	21	consisting	consisting	NN
cord-291950-9gtsqyfj	204	22	of	of	IN
cord-291950-9gtsqyfj	204	23	Cys74	Cys74	NNP
cord-291950-9gtsqyfj	204	24	,	,	,
cord-291950-9gtsqyfj	205	1	Asp278	asp278	LS
cord-291950-9gtsqyfj	206	1	and	and	CC
cord-291950-9gtsqyfj	206	2	His280	his280	UH
cord-291950-9gtsqyfj	206	3	that	that	WDT
cord-291950-9gtsqyfj	206	4	is	be	VBZ
cord-291950-9gtsqyfj	206	5	unusual	unusual	JJ
cord-291950-9gtsqyfj	206	6	amongst	amongst	IN
cord-291950-9gtsqyfj	206	7	papain	papain	NN
cord-291950-9gtsqyfj	206	8	-	-	HYPH
cord-291950-9gtsqyfj	206	9	like	like	JJ
cord-291950-9gtsqyfj	206	10	proteins	protein	NNS
cord-291950-9gtsqyfj	206	11	,	,	,
cord-291950-9gtsqyfj	206	12	in	in	IN
cord-291950-9gtsqyfj	206	13	which	which	WDT
cord-291950-9gtsqyfj	206	14	the	the	DT
cord-291950-9gtsqyfj	206	15	third	third	JJ
cord-291950-9gtsqyfj	206	16	member	member	NN
cord-291950-9gtsqyfj	206	17	of	of	IN
cord-291950-9gtsqyfj	206	18	the	the	DT
cord-291950-9gtsqyfj	206	19	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	206	20	triad	triad	NN
cord-291950-9gtsqyfj	206	21	follows	follow	VBZ
cord-291950-9gtsqyfj	206	22	the	the	DT
cord-291950-9gtsqyfj	206	23	histidine	histidine	NN
cord-291950-9gtsqyfj	206	24	in	in	IN
cord-291950-9gtsqyfj	206	25	the	the	DT
cord-291950-9gtsqyfj	206	26	sequence	sequence	NN
cord-291950-9gtsqyfj	206	27	(	(	-LRB-
cord-291950-9gtsqyfj	206	28	see	see	VB
cord-291950-9gtsqyfj	206	29	Figure	figure	NN
cord-291950-9gtsqyfj	206	30	404	404	CD
cord-291950-9gtsqyfj	206	31	.14	.14	NFP
cord-291950-9gtsqyfj	206	32	)	)	-RRB-
cord-291950-9gtsqyfj	206	33	.	.	.
cord-291950-9gtsqyfj	207	1	Families	family	NNS
cord-291950-9gtsqyfj	207	2	C54	C54	NNP
cord-291950-9gtsqyfj	207	3	and	and	CC
cord-291950-9gtsqyfj	207	4	C78	C78	NNP
cord-291950-9gtsqyfj	207	5	are	be	VBP
cord-291950-9gtsqyfj	207	6	unique	unique	JJ
cord-291950-9gtsqyfj	207	7	in	in	IN
cord-291950-9gtsqyfj	207	8	having	have	VBG
cord-291950-9gtsqyfj	207	9	the	the	DT
cord-291950-9gtsqyfj	207	10	third	third	JJ
cord-291950-9gtsqyfj	207	11	member	member	NN
cord-291950-9gtsqyfj	207	12	(	(	-LRB-
cord-291950-9gtsqyfj	207	13	in	in	IN
cord-291950-9gtsqyfj	207	14	both	both	DT
cord-291950-9gtsqyfj	207	15	families	family	NNS
cord-291950-9gtsqyfj	207	16	an	an	DT
cord-291950-9gtsqyfj	207	17	aspartic	aspartic	JJ
cord-291950-9gtsqyfj	207	18	acid	acid	NN
cord-291950-9gtsqyfj	207	19	)	)	-RRB-
cord-291950-9gtsqyfj	207	20	preceding	precede	VBG
cord-291950-9gtsqyfj	207	21	the	the	DT
cord-291950-9gtsqyfj	207	22	histidine	histidine	NN
cord-291950-9gtsqyfj	207	23	.	.	.
cord-291950-9gtsqyfj	208	1	Members	member	NNS
cord-291950-9gtsqyfj	208	2	of	of	IN
cord-291950-9gtsqyfj	208	3	both	both	DT
cord-291950-9gtsqyfj	208	4	families	family	NNS
cord-291950-9gtsqyfj	208	5	are	be	VBP
cord-291950-9gtsqyfj	208	6	also	also	RB
cord-291950-9gtsqyfj	208	7	unique	unique	JJ
cord-291950-9gtsqyfj	208	8	in	in	IN
cord-291950-9gtsqyfj	208	9	having	have	VBG
cord-291950-9gtsqyfj	208	10	a	a	DT
cord-291950-9gtsqyfj	208	11	tyrosine	tyrosine	NN
cord-291950-9gtsqyfj	208	12	helping	help	VBG
cord-291950-9gtsqyfj	208	13	to	to	TO
cord-291950-9gtsqyfj	208	14	stabilize	stabilize	VB
cord-291950-9gtsqyfj	208	15	the	the	DT
cord-291950-9gtsqyfj	208	16	oxyanion	oxyanion	NN
cord-291950-9gtsqyfj	208	17	hole	hole	NN
cord-291950-9gtsqyfj	208	18	.	.	.
cord-291950-9gtsqyfj	209	1	Family	Family	NNP
cord-291950-9gtsqyfj	209	2	C47	C47	NNP
cord-291950-9gtsqyfj	209	3	includes	include	VBZ
cord-291950-9gtsqyfj	209	4	staphopain	staphopain	NNP
cord-291950-9gtsqyfj	209	5	(	(	-LRB-
cord-291950-9gtsqyfj	209	6	see	see	VB
cord-291950-9gtsqyfj	209	7	Chapters	chapter	NNS
cord-291950-9gtsqyfj	209	8	484	484	CD
cord-291950-9gtsqyfj	209	9	and	and	CC
cord-291950-9gtsqyfj	209	10	485	485	CD
cord-291950-9gtsqyfj	209	11	)	)	-RRB-
cord-291950-9gtsqyfj	209	12	,	,	,
cord-291950-9gtsqyfj	209	13	a	a	DT
cord-291950-9gtsqyfj	209	14	cysteine	cysteine	NN
cord-291950-9gtsqyfj	209	15	peptidase	peptidase	NN
cord-291950-9gtsqyfj	209	16	from	from	IN
cord-291950-9gtsqyfj	209	17	Staphylococcus	Staphylococcus	NNP
cord-291950-9gtsqyfj	209	18	epidermidis	epidermidi	NNS
cord-291950-9gtsqyfj	209	19	.	.	.
cord-291950-9gtsqyfj	210	1	The	the	DT
cord-291950-9gtsqyfj	210	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	210	3	structure	structure	NN
cord-291950-9gtsqyfj	210	4	has	have	VBZ
cord-291950-9gtsqyfj	210	5	been	be	VBN
cord-291950-9gtsqyfj	210	6	determined	determine	VBN
cord-291950-9gtsqyfj	210	7	and	and	CC
cord-291950-9gtsqyfj	210	8	shows	show	VBZ
cord-291950-9gtsqyfj	210	9	a	a	DT
cord-291950-9gtsqyfj	210	10	papain	papain	NN
cord-291950-9gtsqyfj	210	11	-	-	HYPH
cord-291950-9gtsqyfj	210	12	like	like	IN
cord-291950-9gtsqyfj	210	13	fold	fold	VB
cord-291950-9gtsqyfj	210	14	[	[	-LRB-
cord-291950-9gtsqyfj	210	15	31	31	CD
cord-291950-9gtsqyfj	210	16	]	]	-RRB-
cord-291950-9gtsqyfj	210	17	(	(	-LRB-
cord-291950-9gtsqyfj	210	18	see	see	VB
cord-291950-9gtsqyfj	210	19	Figure	figure	NN
cord-291950-9gtsqyfj	210	20	404	404	CD
cord-291950-9gtsqyfj	210	21	.6	.6	CD
cord-291950-9gtsqyfj	210	22	)	)	-RRB-
cord-291950-9gtsqyfj	210	23	.	.	.
cord-291950-9gtsqyfj	211	1	Staphopain	Staphopain	NNP
cord-291950-9gtsqyfj	211	2	is	be	VBZ
cord-291950-9gtsqyfj	211	3	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	211	4	by	by	IN
cord-291950-9gtsqyfj	211	5	E-64	E-64	NNP
cord-291950-9gtsqyfj	211	6	and	and	CC
cord-291950-9gtsqyfj	211	7	cystatin	cystatin	NN
cord-291950-9gtsqyfj	211	8	A.	a.	DT
cord-291950-9gtsqyfj	211	9	Family	Family	NNP
cord-291950-9gtsqyfj	211	10	C39	C39	NNP
cord-291950-9gtsqyfj	211	11	includes	include	VBZ
cord-291950-9gtsqyfj	211	12	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	211	13	that	that	WDT
cord-291950-9gtsqyfj	211	14	are	be	VBP
cord-291950-9gtsqyfj	211	15	involved	involve	VBN
cord-291950-9gtsqyfj	211	16	in	in	IN
cord-291950-9gtsqyfj	211	17	the	the	DT
cord-291950-9gtsqyfj	211	18	processing	processing	NN
cord-291950-9gtsqyfj	211	19	and	and	CC
cord-291950-9gtsqyfj	211	20	export	export	NN
cord-291950-9gtsqyfj	211	21	of	of	IN
cord-291950-9gtsqyfj	211	22	bacteriocins	bacteriocin	NNS
cord-291950-9gtsqyfj	211	23	.	.	.
cord-291950-9gtsqyfj	212	1	Bacteriocins	bacteriocin	NNS
cord-291950-9gtsqyfj	212	2	are	be	VBP
cord-291950-9gtsqyfj	212	3	antibiotic	antibiotic	JJ
cord-291950-9gtsqyfj	212	4	proteins	protein	NNS
cord-291950-9gtsqyfj	212	5	secreted	secrete	VBN
cord-291950-9gtsqyfj	212	6	by	by	IN
cord-291950-9gtsqyfj	212	7	some	some	DT
cord-291950-9gtsqyfj	212	8	species	specie	NNS
cord-291950-9gtsqyfj	212	9	of	of	IN
cord-291950-9gtsqyfj	212	10	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	212	11	that	that	WDT
cord-291950-9gtsqyfj	212	12	have	have	VBP
cord-291950-9gtsqyfj	212	13	the	the	DT
cord-291950-9gtsqyfj	212	14	effect	effect	NN
cord-291950-9gtsqyfj	212	15	of	of	IN
cord-291950-9gtsqyfj	212	16	inhibiting	inhibit	VBG
cord-291950-9gtsqyfj	212	17	the	the	DT
cord-291950-9gtsqyfj	212	18	growth	growth	NN
cord-291950-9gtsqyfj	212	19	of	of	IN
cord-291950-9gtsqyfj	212	20	other	other	JJ
cord-291950-9gtsqyfj	212	21	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	212	22	species	specie	NNS
cord-291950-9gtsqyfj	212	23	.	.	.
cord-291950-9gtsqyfj	213	1	The	the	DT
cord-291950-9gtsqyfj	213	2	bacteriocin	bacteriocin	NNS
cord-291950-9gtsqyfj	213	3	is	be	VBZ
cord-291950-9gtsqyfj	213	4	synthesized	synthesize	VBN
cord-291950-9gtsqyfj	213	5	as	as	IN
cord-291950-9gtsqyfj	213	6	a	a	DT
cord-291950-9gtsqyfj	213	7	precursor	precursor	NN
cord-291950-9gtsqyfj	213	8	with	with	IN
cord-291950-9gtsqyfj	213	9	an	an	DT
cord-291950-9gtsqyfj	213	10	N	n	CD
cord-291950-9gtsqyfj	213	11	-	-	HYPH
cord-291950-9gtsqyfj	213	12	terminal	terminal	JJ
cord-291950-9gtsqyfj	213	13	leader	leader	NN
cord-291950-9gtsqyfj	213	14	peptide	peptide	NN
cord-291950-9gtsqyfj	213	15	,	,	,
cord-291950-9gtsqyfj	213	16	and	and	CC
cord-291950-9gtsqyfj	213	17	processing	processing	NN
cord-291950-9gtsqyfj	213	18	involves	involve	VBZ
cord-291950-9gtsqyfj	213	19	removal	removal	NN
cord-291950-9gtsqyfj	213	20	of	of	IN
cord-291950-9gtsqyfj	213	21	the	the	DT
cord-291950-9gtsqyfj	213	22	leader	leader	NN
cord-291950-9gtsqyfj	213	23	peptide	peptide	NN
cord-291950-9gtsqyfj	213	24	at	at	IN
cord-291950-9gtsqyfj	213	25	a	a	DT
cord-291950-9gtsqyfj	213	26	Gly	Gly	NNP
cord-291950-9gtsqyfj	213	27	-	-	HYPH
cord-291950-9gtsqyfj	213	28	Glyk	Glyk	NNP
cord-291950-9gtsqyfj	213	29	bond	bond	NN
cord-291950-9gtsqyfj	213	30	,	,	,
cord-291950-9gtsqyfj	213	31	followed	follow	VBN
cord-291950-9gtsqyfj	213	32	by	by	IN
cord-291950-9gtsqyfj	213	33	translocation	translocation	NN
cord-291950-9gtsqyfj	213	34	of	of	IN
cord-291950-9gtsqyfj	213	35	the	the	DT
cord-291950-9gtsqyfj	213	36	mature	mature	JJ
cord-291950-9gtsqyfj	213	37	bacteriocin	bacteriocin	NNS
cord-291950-9gtsqyfj	213	38	across	across	IN
cord-291950-9gtsqyfj	213	39	the	the	DT
cord-291950-9gtsqyfj	213	40	cytoplasmic	cytoplasmic	JJ
cord-291950-9gtsqyfj	213	41	membrane	membrane	NN
cord-291950-9gtsqyfj	213	42	.	.	.
cord-291950-9gtsqyfj	214	1	The	the	DT
cord-291950-9gtsqyfj	214	2	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	214	3	serves	serve	VBZ
cord-291950-9gtsqyfj	214	4	both	both	DT
cord-291950-9gtsqyfj	214	5	functions	function	NNS
cord-291950-9gtsqyfj	214	6	,	,	,
cord-291950-9gtsqyfj	214	7	and	and	CC
cord-291950-9gtsqyfj	214	8	is	be	VBZ
cord-291950-9gtsqyfj	214	9	also	also	RB
cord-291950-9gtsqyfj	214	10	known	know	VBN
cord-291950-9gtsqyfj	214	11	as	as	IN
cord-291950-9gtsqyfj	214	12	an	an	DT
cord-291950-9gtsqyfj	214	13	ATPbinding	atpbinde	VBG
cord-291950-9gtsqyfj	214	14	cassette	cassette	NN
cord-291950-9gtsqyfj	214	15	transporter	transporter	NN
cord-291950-9gtsqyfj	214	16	or	or	CC
cord-291950-9gtsqyfj	214	17	ABC	ABC	NNP
cord-291950-9gtsqyfj	214	18	-	-	HYPH
cord-291950-9gtsqyfj	214	19	transporter	transporter	NN
cord-291950-9gtsqyfj	214	20	.	.	.
cord-291950-9gtsqyfj	215	1	The	the	DT
cord-291950-9gtsqyfj	215	2	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	215	3	are	be	VBP
cord-291950-9gtsqyfj	215	4	integral	integral	JJ
cord-291950-9gtsqyfj	215	5	membrane	membrane	NN
cord-291950-9gtsqyfj	215	6	proteins	protein	NNS
cord-291950-9gtsqyfj	215	7	containing	contain	VBG
cord-291950-9gtsqyfj	215	8	an	an	DT
cord-291950-9gtsqyfj	215	9	N	n	CD
cord-291950-9gtsqyfj	215	10	-	-	HYPH
cord-291950-9gtsqyfj	215	11	terminal	terminal	JJ
cord-291950-9gtsqyfj	215	12	peptidase	peptidase	NN
cord-291950-9gtsqyfj	215	13	domain	domain	NN
cord-291950-9gtsqyfj	215	14	followed	follow	VBN
cord-291950-9gtsqyfj	215	15	by	by	IN
cord-291950-9gtsqyfj	215	16	six	six	CD
cord-291950-9gtsqyfj	215	17	or	or	CC
cord-291950-9gtsqyfj	215	18	more	more	JJR
cord-291950-9gtsqyfj	215	19	transmembrane	transmembrane	NN
cord-291950-9gtsqyfj	215	20	domains	domain	NNS
cord-291950-9gtsqyfj	215	21	and	and	CC
cord-291950-9gtsqyfj	215	22	a	a	DT
cord-291950-9gtsqyfj	215	23	C	c	NN
cord-291950-9gtsqyfj	215	24	-	-	HYPH
cord-291950-9gtsqyfj	215	25	terminal	terminal	NN
cord-291950-9gtsqyfj	215	26	ATPbinding	atpbinding	NN
cord-291950-9gtsqyfj	215	27	domain	domain	NN
cord-291950-9gtsqyfj	215	28	.	.	.
cord-291950-9gtsqyfj	216	1	The	the	DT
cord-291950-9gtsqyfj	216	2	structure	structure	NN
cord-291950-9gtsqyfj	216	3	of	of	IN
cord-291950-9gtsqyfj	216	4	the	the	DT
cord-291950-9gtsqyfj	216	5	peptidase	peptidase	NN
cord-291950-9gtsqyfj	216	6	domain	domain	NN
cord-291950-9gtsqyfj	216	7	has	have	VBZ
cord-291950-9gtsqyfj	216	8	been	be	VBN
cord-291950-9gtsqyfj	216	9	solved	solve	VBN
cord-291950-9gtsqyfj	216	10	,	,	,
cord-291950-9gtsqyfj	216	11	and	and	CC
cord-291950-9gtsqyfj	216	12	shows	show	VBZ
cord-291950-9gtsqyfj	216	13	a	a	DT
cord-291950-9gtsqyfj	216	14	papain	papain	NN
cord-291950-9gtsqyfj	216	15	-	-	HYPH
cord-291950-9gtsqyfj	216	16	like	like	IN
cord-291950-9gtsqyfj	216	17	fold	fold	VB
cord-291950-9gtsqyfj	216	18	(	(	-LRB-
cord-291950-9gtsqyfj	216	19	see	see	VB
cord-291950-9gtsqyfj	216	20	Figure	figure	NN
cord-291950-9gtsqyfj	216	21	404	404	CD
cord-291950-9gtsqyfj	216	22	.15	.15	NFP
cord-291950-9gtsqyfj	216	23	)	)	-RRB-
cord-291950-9gtsqyfj	217	1	[	[	-LRB-
cord-291950-9gtsqyfj	217	2	32	32	CD
cord-291950-9gtsqyfj	217	3	]	]	-RRB-
cord-291950-9gtsqyfj	217	4	.	.	.
cord-291950-9gtsqyfj	218	1	The	the	DT
cord-291950-9gtsqyfj	218	2	non	non	JJ
cord-291950-9gtsqyfj	218	3	-	-	JJ
cord-291950-9gtsqyfj	218	4	peptidase	peptidase	JJ
cord-291950-9gtsqyfj	218	5	-	-	HYPH
cord-291950-9gtsqyfj	218	6	domains	domain	NNS
cord-291950-9gtsqyfj	218	7	are	be	VBP
cord-291950-9gtsqyfj	218	8	homologous	homologous	JJ
cord-291950-9gtsqyfj	218	9	to	to	IN
cord-291950-9gtsqyfj	218	10	a	a	DT
cord-291950-9gtsqyfj	218	11	variety	variety	NN
cord-291950-9gtsqyfj	218	12	of	of	IN
cord-291950-9gtsqyfj	218	13	other	other	JJ
cord-291950-9gtsqyfj	218	14	ABC	ABC	NNP
cord-291950-9gtsqyfj	218	15	-	-	HYPH
cord-291950-9gtsqyfj	218	16	transport	transport	NN
cord-291950-9gtsqyfj	218	17	proteins	protein	NNS
cord-291950-9gtsqyfj	218	18	.	.	.
cord-291950-9gtsqyfj	219	1	Peptidase	peptidase	JJ
cord-291950-9gtsqyfj	219	2	specificity	specificity	NN
cord-291950-9gtsqyfj	219	3	is	be	VBZ
cord-291950-9gtsqyfj	219	4	not	not	RB
cord-291950-9gtsqyfj	219	5	unlike	unlike	IN
cord-291950-9gtsqyfj	219	6	that	that	DT
cord-291950-9gtsqyfj	219	7	of	of	IN
cord-291950-9gtsqyfj	219	8	the	the	DT
cord-291950-9gtsqyfj	219	9	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	219	10	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	219	11	.	.	.
cord-291950-9gtsqyfj	220	1	The	the	DT
cord-291950-9gtsqyfj	220	2	complex	complex	JJ
cord-291950-9gtsqyfj	220	3	structure	structure	NN
cord-291950-9gtsqyfj	220	4	of	of	IN
cord-291950-9gtsqyfj	220	5	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	220	6	cell	cell	NN
cord-291950-9gtsqyfj	220	7	walls	wall	NNS
cord-291950-9gtsqyfj	220	8	means	mean	VBZ
cord-291950-9gtsqyfj	220	9	that	that	IN
cord-291950-9gtsqyfj	220	10	there	there	EX
cord-291950-9gtsqyfj	220	11	are	be	VBP
cord-291950-9gtsqyfj	220	12	a	a	DT
cord-291950-9gtsqyfj	220	13	large	large	JJ
cord-291950-9gtsqyfj	220	14	number	number	NN
cord-291950-9gtsqyfj	220	15	of	of	IN
cord-291950-9gtsqyfj	220	16	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	220	17	involved	involve	VBN
cord-291950-9gtsqyfj	220	18	in	in	IN
cord-291950-9gtsqyfj	220	19	cell	cell	NN
cord-291950-9gtsqyfj	220	20	wall	wall	NN
cord-291950-9gtsqyfj	220	21	processing	processing	NN
cord-291950-9gtsqyfj	220	22	and	and	CC
cord-291950-9gtsqyfj	220	23	lysis	lysis	NN
cord-291950-9gtsqyfj	220	24	.	.	.
cord-291950-9gtsqyfj	221	1	Newly	newly	RB
cord-291950-9gtsqyfj	221	2	synthesized	synthesize	VBN
cord-291950-9gtsqyfj	221	3	bacteriophage	bacteriophage	NN
cord-291950-9gtsqyfj	221	4	virions	virion	NNS
cord-291950-9gtsqyfj	221	5	escape	escape	VB
cord-291950-9gtsqyfj	221	6	from	from	IN
cord-291950-9gtsqyfj	221	7	the	the	DT
cord-291950-9gtsqyfj	221	8	host	host	NN
cord-291950-9gtsqyfj	221	9	cell	cell	NN
cord-291950-9gtsqyfj	221	10	by	by	IN
cord-291950-9gtsqyfj	221	11	lysing	lyse	VBG
cord-291950-9gtsqyfj	221	12	it	-PRON-	PRP
cord-291950-9gtsqyfj	221	13	,	,	,
cord-291950-9gtsqyfj	221	14	and	and	CC
cord-291950-9gtsqyfj	221	15	the	the	DT
cord-291950-9gtsqyfj	221	16	bacteriophage	bacteriophage	NN
cord-291950-9gtsqyfj	221	17	genomes	genome	NNS
cord-291950-9gtsqyfj	221	18	encode	encode	VBP
cord-291950-9gtsqyfj	221	19	a	a	DT
cord-291950-9gtsqyfj	221	20	cell	cell	NN
cord-291950-9gtsqyfj	221	21	wall	wall	NN
cord-291950-9gtsqyfj	221	22	lytic	lytic	JJ
cord-291950-9gtsqyfj	221	23	enzyme	enzyme	NN
cord-291950-9gtsqyfj	221	24	that	that	WDT
cord-291950-9gtsqyfj	221	25	acts	act	VBZ
cord-291950-9gtsqyfj	221	26	either	either	CC
cord-291950-9gtsqyfj	221	27	as	as	IN
cord-291950-9gtsqyfj	221	28	a	a	DT
cord-291950-9gtsqyfj	221	29	peptidase	peptidase	NN
cord-291950-9gtsqyfj	221	30	to	to	TO
cord-291950-9gtsqyfj	221	31	degrade	degrade	VB
cord-291950-9gtsqyfj	221	32	the	the	DT
cord-291950-9gtsqyfj	221	33	cell	cell	NN
cord-291950-9gtsqyfj	221	34	wall	wall	NN
cord-291950-9gtsqyfj	221	35	crosslinks	crosslink	NNS
cord-291950-9gtsqyfj	221	36	,	,	,
cord-291950-9gtsqyfj	221	37	or	or	CC
cord-291950-9gtsqyfj	221	38	as	as	IN
cord-291950-9gtsqyfj	221	39	an	an	DT
cord-291950-9gtsqyfj	221	40	amidase	amidase	NN
cord-291950-9gtsqyfj	221	41	to	to	TO
cord-291950-9gtsqyfj	221	42	disrupt	disrupt	VB
cord-291950-9gtsqyfj	221	43	the	the	DT
cord-291950-9gtsqyfj	221	44	acetylmuramyl	acetylmuramyl	JJ
cord-291950-9gtsqyfj	221	45	bonds	bond	NNS
cord-291950-9gtsqyfj	221	46	.	.	.
cord-291950-9gtsqyfj	222	1	Staphylococcus	Staphylococcus	NNP
cord-291950-9gtsqyfj	222	2	aureus	aureus	NN
cord-291950-9gtsqyfj	222	3	has	have	VBZ
cord-291950-9gtsqyfj	222	4	a	a	DT
cord-291950-9gtsqyfj	222	5	multi	multi	JJ
cord-291950-9gtsqyfj	222	6	-	-	JJ
cord-291950-9gtsqyfj	222	7	domain	domain	NN
cord-291950-9gtsqyfj	222	8	enzyme	enzyme	NN
cord-291950-9gtsqyfj	222	9	known	know	VBN
cord-291950-9gtsqyfj	222	10	as	as	IN
cord-291950-9gtsqyfj	222	11	autolysin	autolysin	NNP
cord-291950-9gtsqyfj	223	1	the	the	DT
cord-291950-9gtsqyfj	223	2	C	C	NNP
cord-291950-9gtsqyfj	223	3	-	-	HYPH
cord-291950-9gtsqyfj	223	4	terminal	terminal	NN
cord-291950-9gtsqyfj	223	5	domain	domain	NN
cord-291950-9gtsqyfj	223	6	of	of	IN
cord-291950-9gtsqyfj	223	7	which	which	WDT
cord-291950-9gtsqyfj	223	8	is	be	VBZ
cord-291950-9gtsqyfj	223	9	related	relate	VBN
cord-291950-9gtsqyfj	223	10	to	to	IN
cord-291950-9gtsqyfj	223	11	lysostaphin	lysostaphin	NNP
cord-291950-9gtsqyfj	223	12	(	(	-LRB-
cord-291950-9gtsqyfj	223	13	peptidase	peptidase	NN
cord-291950-9gtsqyfj	223	14	family	family	NN
cord-291950-9gtsqyfj	223	15	M37	M37	NNP
cord-291950-9gtsqyfj	223	16	)	)	-RRB-
cord-291950-9gtsqyfj	223	17	.	.	.
cord-291950-9gtsqyfj	224	1	The	the	DT
cord-291950-9gtsqyfj	224	2	autolysin	autolysin	NNP
cord-291950-9gtsqyfj	224	3	gene	gene	NN
cord-291950-9gtsqyfj	224	4	has	have	VBZ
cord-291950-9gtsqyfj	224	5	been	be	VBN
cord-291950-9gtsqyfj	224	6	acquired	acquire	VBN
cord-291950-9gtsqyfj	224	7	by	by	IN
cord-291950-9gtsqyfj	224	8	a	a	DT
cord-291950-9gtsqyfj	224	9	number	number	NN
cord-291950-9gtsqyfj	224	10	of	of	IN
cord-291950-9gtsqyfj	224	11	staphylococcal	staphylococcal	JJ
cord-291950-9gtsqyfj	224	12	phages	phage	NNS
cord-291950-9gtsqyfj	224	13	,	,	,
cord-291950-9gtsqyfj	224	14	and	and	CC
cord-291950-9gtsqyfj	224	15	in	in	IN
cord-291950-9gtsqyfj	224	16	bacteriophage	bacteriophage	NN
cord-291950-9gtsqyfj	224	17	ϕ11	ϕ11	NNP
cord-291950-9gtsqyfj	224	18	,	,	,
cord-291950-9gtsqyfj	224	19	autolysin	autolysin	NNP
cord-291950-9gtsqyfj	224	20	has	have	VBZ
cord-291950-9gtsqyfj	224	21	been	be	VBN
cord-291950-9gtsqyfj	224	22	shown	show	VBN
cord-291950-9gtsqyfj	224	23	to	to	TO
cord-291950-9gtsqyfj	224	24	cleave	cleave	VB
cord-291950-9gtsqyfj	224	25	the	the	DT
cord-291950-9gtsqyfj	224	26	cell	cell	NN
cord-291950-9gtsqyfj	224	27	wall	wall	NN
cord-291950-9gtsqyfj	224	28	cross	cross	NNP
cord-291950-9gtsqyfj	224	29	-	-	JJ
cord-291950-9gtsqyfj	224	30	linking	link	VBG
cord-291950-9gtsqyfj	224	31	peptide	peptide	NN
cord-291950-9gtsqyfj	224	32	at	at	IN
cord-291950-9gtsqyfj	224	33	D	D	NNP
cord-291950-9gtsqyfj	224	34	-	-	HYPH
cord-291950-9gtsqyfj	224	35	AlakGly	AlakGly	NNP
cord-291950-9gtsqyfj	224	36	.	.	.
cord-291950-9gtsqyfj	225	1	The	the	DT
cord-291950-9gtsqyfj	225	2	peptidase	peptidase	NN
cord-291950-9gtsqyfj	225	3	activity	activity	NN
cord-291950-9gtsqyfj	225	4	is	be	VBZ
cord-291950-9gtsqyfj	225	5	expressed	express	VBN
cord-291950-9gtsqyfj	225	6	by	by	IN
cord-291950-9gtsqyfj	225	7	the	the	DT
cord-291950-9gtsqyfj	225	8	Nterminal	Nterminal	NNP
cord-291950-9gtsqyfj	225	9	domain	domain	NN
cord-291950-9gtsqyfj	225	10	[	[	-LRB-
cord-291950-9gtsqyfj	225	11	33	33	CD
cord-291950-9gtsqyfj	225	12	]	]	-RRB-
cord-291950-9gtsqyfj	225	13	.	.	.
cord-291950-9gtsqyfj	226	1	An	an	DT
cord-291950-9gtsqyfj	226	2	alignment	alignment	NN
cord-291950-9gtsqyfj	226	3	shows	show	VBZ
cord-291950-9gtsqyfj	226	4	that	that	IN
cord-291950-9gtsqyfj	226	5	residues	residue	VBZ
cord-291950-9gtsqyfj	226	6	Gln31	Gln31	NNP
cord-291950-9gtsqyfj	226	7	,	,	,
cord-291950-9gtsqyfj	226	8	Cys32	Cys32	NNP
cord-291950-9gtsqyfj	226	9	,	,	,
cord-291950-9gtsqyfj	226	10	His95	His95	NNP
cord-291950-9gtsqyfj	226	11	and	and	CC
cord-291950-9gtsqyfj	226	12	Asn113	Asn113	NNS
cord-291950-9gtsqyfj	226	13	are	be	VBP
cord-291950-9gtsqyfj	226	14	conserved	conserve	VBN
cord-291950-9gtsqyfj	226	15	,	,	,
cord-291950-9gtsqyfj	226	16	suggesting	suggest	VBG
cord-291950-9gtsqyfj	226	17	that	that	IN
cord-291950-9gtsqyfj	226	18	the	the	DT
cord-291950-9gtsqyfj	226	19	N	n	CD
cord-291950-9gtsqyfj	226	20	-	-	HYPH
cord-291950-9gtsqyfj	226	21	terminal	terminal	NN
cord-291950-9gtsqyfj	226	22	domain	domain	NN
cord-291950-9gtsqyfj	226	23	is	be	VBZ
cord-291950-9gtsqyfj	226	24	a	a	DT
cord-291950-9gtsqyfj	226	25	cysteine	cysteine	JJ
cord-291950-9gtsqyfj	226	26	peptidase	peptidase	NN
cord-291950-9gtsqyfj	226	27	with	with	IN
cord-291950-9gtsqyfj	226	28	a	a	DT
cord-291950-9gtsqyfj	226	29	papain	papain	NN
cord-291950-9gtsqyfj	226	30	-	-	HYPH
cord-291950-9gtsqyfj	226	31	like	like	IN
cord-291950-9gtsqyfj	226	32	fold	fold	NN
cord-291950-9gtsqyfj	226	33	,	,	,
cord-291950-9gtsqyfj	226	34	which	which	WDT
cord-291950-9gtsqyfj	226	35	we	-PRON-	PRP
cord-291950-9gtsqyfj	226	36	include	include	VBP
cord-291950-9gtsqyfj	226	37	in	in	IN
cord-291950-9gtsqyfj	226	38	family	family	NN
cord-291950-9gtsqyfj	226	39	C51	C51	NNP
cord-291950-9gtsqyfj	226	40	.	.	.
cord-291950-9gtsqyfj	227	1	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	227	2	syringae	syringae	NN
cord-291950-9gtsqyfj	227	3	is	be	VBZ
cord-291950-9gtsqyfj	227	4	a	a	DT
cord-291950-9gtsqyfj	227	5	plant	plant	NN
cord-291950-9gtsqyfj	227	6	pathogen	pathogen	NN
cord-291950-9gtsqyfj	227	7	which	which	WDT
cord-291950-9gtsqyfj	227	8	secretes	secrete	VBZ
cord-291950-9gtsqyfj	227	9	disease	disease	NN
cord-291950-9gtsqyfj	227	10	-	-	HYPH
cord-291950-9gtsqyfj	227	11	causing	cause	VBG
cord-291950-9gtsqyfj	227	12	factors	factor	NNS
cord-291950-9gtsqyfj	227	13	into	into	IN
cord-291950-9gtsqyfj	227	14	the	the	DT
cord-291950-9gtsqyfj	227	15	host	host	NN
cord-291950-9gtsqyfj	227	16	cell	cell	NN
cord-291950-9gtsqyfj	227	17	via	via	IN
cord-291950-9gtsqyfj	227	18	its	-PRON-	PRP$
cord-291950-9gtsqyfj	227	19	type	type	NN
cord-291950-9gtsqyfj	227	20	III	iii	CD
cord-291950-9gtsqyfj	227	21	secretion	secretion	NN
cord-291950-9gtsqyfj	227	22	pathway	pathway	NN
cord-291950-9gtsqyfj	227	23	[	[	-LRB-
cord-291950-9gtsqyfj	227	24	34	34	CD
cord-291950-9gtsqyfj	227	25	]	]	-RRB-
cord-291950-9gtsqyfj	227	26	.	.	.
cord-291950-9gtsqyfj	228	1	The	the	DT
cord-291950-9gtsqyfj	228	2	AvrRpt2	AvrRpt2	NNP
cord-291950-9gtsqyfj	228	3	protein	protein	NN
cord-291950-9gtsqyfj	228	4	(	(	-LRB-
cord-291950-9gtsqyfj	228	5	Chapter	chapter	NN
cord-291950-9gtsqyfj	228	6	552	552	CD
cord-291950-9gtsqyfj	228	7	)	)	-RRB-
cord-291950-9gtsqyfj	228	8	is	be	VBZ
cord-291950-9gtsqyfj	228	9	one	one	CD
cord-291950-9gtsqyfj	228	10	of	of	IN
cord-291950-9gtsqyfj	228	11	these	these	DT
cord-291950-9gtsqyfj	228	12	virulence	virulence	NN
cord-291950-9gtsqyfj	228	13	factors	factor	NNS
cord-291950-9gtsqyfj	228	14	which	which	WDT
cord-291950-9gtsqyfj	228	15	activates	activate	VBZ
cord-291950-9gtsqyfj	228	16	itself	-PRON-	PRP
cord-291950-9gtsqyfj	228	17	and	and	CC
cord-291950-9gtsqyfj	228	18	probably	probably	RB
cord-291950-9gtsqyfj	228	19	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	228	20	the	the	DT
cord-291950-9gtsqyfj	228	21	RIN4	RIN4	NNP
cord-291950-9gtsqyfj	228	22	protein	protein	NN
cord-291950-9gtsqyfj	228	23	of	of	IN
cord-291950-9gtsqyfj	228	24	the	the	DT
cord-291950-9gtsqyfj	228	25	host	host	NN
cord-291950-9gtsqyfj	228	26	plant	plant	NN
cord-291950-9gtsqyfj	228	27	cell	cell	NN
cord-291950-9gtsqyfj	228	28	.	.	.
cord-291950-9gtsqyfj	229	1	By	by	IN
cord-291950-9gtsqyfj	229	2	comparison	comparison	NN
cord-291950-9gtsqyfj	229	3	with	with	IN
cord-291950-9gtsqyfj	229	4	staphopain	staphopain	NNP
cord-291950-9gtsqyfj	229	5	,	,	,
cord-291950-9gtsqyfj	229	6	AvrRpt2	AvrRpt2	NNP
cord-291950-9gtsqyfj	229	7	protein	protein	NN
cord-291950-9gtsqyfj	229	8	has	have	VBZ
cord-291950-9gtsqyfj	229	9	been	be	VBN
cord-291950-9gtsqyfj	229	10	predicted	predict	VBN
cord-291950-9gtsqyfj	229	11	to	to	TO
cord-291950-9gtsqyfj	229	12	be	be	VB
cord-291950-9gtsqyfj	229	13	a	a	DT
cord-291950-9gtsqyfj	229	14	cysteine	cysteine	JJ
cord-291950-9gtsqyfj	229	15	peptidase	peptidase	NN
cord-291950-9gtsqyfj	229	16	with	with	IN
cord-291950-9gtsqyfj	229	17	a	a	DT
cord-291950-9gtsqyfj	229	18	Cys	Cys	NNP
cord-291950-9gtsqyfj	229	19	,	,	,
cord-291950-9gtsqyfj	229	20	His	His	NNP
cord-291950-9gtsqyfj	229	21	and	and	CC
cord-291950-9gtsqyfj	229	22	Asp	Asp	NNP
cord-291950-9gtsqyfj	229	23	,	,	,
cord-291950-9gtsqyfj	229	24	papain	papain	NN
cord-291950-9gtsqyfj	229	25	-	-	HYPH
cord-291950-9gtsqyfj	229	26	like	like	JJ
cord-291950-9gtsqyfj	229	27	,	,	,
cord-291950-9gtsqyfj	229	28	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	229	29	triad	triad	NN
cord-291950-9gtsqyfj	229	30	,	,	,
cord-291950-9gtsqyfj	229	31	and	and	CC
cord-291950-9gtsqyfj	229	32	mutation	mutation	NN
cord-291950-9gtsqyfj	229	33	of	of	IN
cord-291950-9gtsqyfj	229	34	any	any	DT
cord-291950-9gtsqyfj	229	35	of	of	IN
cord-291950-9gtsqyfj	229	36	these	these	DT
cord-291950-9gtsqyfj	229	37	residues	residue	NNS
cord-291950-9gtsqyfj	229	38	prevented	prevent	VBD
cord-291950-9gtsqyfj	229	39	autoactivation	autoactivation	NN
cord-291950-9gtsqyfj	229	40	or	or	CC
cord-291950-9gtsqyfj	229	41	RIN4	RIN4	NNP
cord-291950-9gtsqyfj	229	42	digestion	digestion	NN
cord-291950-9gtsqyfj	229	43	[	[	-LRB-
cord-291950-9gtsqyfj	229	44	35	35	CD
cord-291950-9gtsqyfj	229	45	]	]	-RRB-
cord-291950-9gtsqyfj	229	46	.	.	.
cord-291950-9gtsqyfj	230	1	The	the	DT
cord-291950-9gtsqyfj	230	2	AvrRpt2	AvrRpt2	NNP
cord-291950-9gtsqyfj	230	3	protein	protein	NN
cord-291950-9gtsqyfj	230	4	is	be	VBZ
cord-291950-9gtsqyfj	230	5	included	include	VBN
cord-291950-9gtsqyfj	230	6	in	in	IN
cord-291950-9gtsqyfj	230	7	family	family	NN
cord-291950-9gtsqyfj	230	8	C70	C70	NNP
cord-291950-9gtsqyfj	230	9	.	.	.
cord-291950-9gtsqyfj	231	1	Family	Family	NNP
cord-291950-9gtsqyfj	231	2	C58	C58	NNP
cord-291950-9gtsqyfj	231	3	includes	include	VBZ
cord-291950-9gtsqyfj	231	4	the	the	DT
cord-291950-9gtsqyfj	231	5	YopT	YopT	NNP
cord-291950-9gtsqyfj	231	6	effector	effector	NN
cord-291950-9gtsqyfj	231	7	protein	protein	NN
cord-291950-9gtsqyfj	231	8	from	from	IN
cord-291950-9gtsqyfj	231	9	the	the	DT
cord-291950-9gtsqyfj	231	10	plague	plague	NN
cord-291950-9gtsqyfj	231	11	organism	organism	NN
cord-291950-9gtsqyfj	231	12	Yersinia	Yersinia	NNP
cord-291950-9gtsqyfj	231	13	pestis	pestis	NN
cord-291950-9gtsqyfj	231	14	.	.	.
cord-291950-9gtsqyfj	232	1	The	the	DT
cord-291950-9gtsqyfj	232	2	Yop	Yop	NNP
cord-291950-9gtsqyfj	232	3	effectors	effector	NNS
cord-291950-9gtsqyfj	232	4	are	be	VBP
cord-291950-9gtsqyfj	232	5	proteins	protein	NNS
cord-291950-9gtsqyfj	232	6	secreted	secrete	VBN
cord-291950-9gtsqyfj	232	7	into	into	IN
cord-291950-9gtsqyfj	232	8	host	host	NN
cord-291950-9gtsqyfj	232	9	cells	cell	NNS
cord-291950-9gtsqyfj	232	10	that	that	WDT
cord-291950-9gtsqyfj	232	11	disrupt	disrupt	VBP
cord-291950-9gtsqyfj	232	12	the	the	DT
cord-291950-9gtsqyfj	232	13	immune	immune	JJ
cord-291950-9gtsqyfj	232	14	response	response	NN
cord-291950-9gtsqyfj	232	15	;	;	:
cord-291950-9gtsqyfj	232	16	two	two	CD
cord-291950-9gtsqyfj	232	17	of	of	IN
cord-291950-9gtsqyfj	232	18	these	these	DT
cord-291950-9gtsqyfj	232	19	effectors	effector	NNS
cord-291950-9gtsqyfj	232	20	are	be	VBP
cord-291950-9gtsqyfj	232	21	now	now	RB
cord-291950-9gtsqyfj	232	22	known	know	VBN
cord-291950-9gtsqyfj	232	23	to	to	TO
cord-291950-9gtsqyfj	232	24	be	be	VB
cord-291950-9gtsqyfj	232	25	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	232	26	,	,	,
cord-291950-9gtsqyfj	232	27	YopT	YopT	NNP
cord-291950-9gtsqyfj	232	28	and	and	CC
cord-291950-9gtsqyfj	232	29	YopJ	YopJ	NNP
cord-291950-9gtsqyfj	232	30	(	(	-LRB-
cord-291950-9gtsqyfj	232	31	see	see	VB
cord-291950-9gtsqyfj	232	32	Chapter	chapter	NN
cord-291950-9gtsqyfj	232	33	488	488	CD
cord-291950-9gtsqyfj	232	34	)	)	-RRB-
cord-291950-9gtsqyfj	232	35	.	.	.
cord-291950-9gtsqyfj	233	1	The	the	DT
cord-291950-9gtsqyfj	233	2	YopT	YopT	NNP
cord-291950-9gtsqyfj	233	3	effector	effector	NN
cord-291950-9gtsqyfj	233	4	has	have	VBZ
cord-291950-9gtsqyfj	233	5	been	be	VBN
cord-291950-9gtsqyfj	233	6	shown	show	VBN
cord-291950-9gtsqyfj	233	7	to	to	TO
cord-291950-9gtsqyfj	233	8	be	be	VB
cord-291950-9gtsqyfj	233	9	a	a	DT
cord-291950-9gtsqyfj	233	10	cysteine	cysteine	NN
cord-291950-9gtsqyfj	233	11	peptidase	peptidase	NN
cord-291950-9gtsqyfj	233	12	,	,	,
cord-291950-9gtsqyfj	233	13	and	and	CC
cord-291950-9gtsqyfj	233	14	is	be	VBZ
cord-291950-9gtsqyfj	233	15	known	know	VBN
cord-291950-9gtsqyfj	233	16	to	to	TO
cord-291950-9gtsqyfj	233	17	remove	remove	VB
cord-291950-9gtsqyfj	233	18	a	a	DT
cord-291950-9gtsqyfj	233	19	C	c	NN
cord-291950-9gtsqyfj	233	20	-	-	HYPH
cord-291950-9gtsqyfj	233	21	terminal	terminal	JJ
cord-291950-9gtsqyfj	233	22	prenylated	prenylate	VBN
cord-291950-9gtsqyfj	233	23	cysteine	cysteine	NN
cord-291950-9gtsqyfj	233	24	(	(	-LRB-
cord-291950-9gtsqyfj	233	25	or	or	CC
cord-291950-9gtsqyfj	233	26	a	a	DT
cord-291950-9gtsqyfj	233	27	short	short	JJ
cord-291950-9gtsqyfj	233	28	peptide	peptide	NN
cord-291950-9gtsqyfj	233	29	containing	contain	VBG
cord-291950-9gtsqyfj	233	30	the	the	DT
cord-291950-9gtsqyfj	233	31	C	C	NNP
cord-291950-9gtsqyfj	233	32	-	-	HYPH
cord-291950-9gtsqyfj	233	33	terminal	terminal	NN
cord-291950-9gtsqyfj	233	34	cysteine	cysteine	NN
cord-291950-9gtsqyfj	233	35	)	)	-RRB-
cord-291950-9gtsqyfj	233	36	from	from	IN
cord-291950-9gtsqyfj	233	37	GTPases	gtpase	NNS
cord-291950-9gtsqyfj	233	38	.	.	.
cord-291950-9gtsqyfj	234	1	The	the	DT
cord-291950-9gtsqyfj	234	2	effect	effect	NN
cord-291950-9gtsqyfj	234	3	is	be	VBZ
cord-291950-9gtsqyfj	234	4	to	to	TO
cord-291950-9gtsqyfj	234	5	release	release	VB
cord-291950-9gtsqyfj	234	6	the	the	DT
cord-291950-9gtsqyfj	234	7	GTPase	GTPase	NNP
cord-291950-9gtsqyfj	234	8	from	from	IN
cord-291950-9gtsqyfj	234	9	the	the	DT
cord-291950-9gtsqyfj	234	10	membrane	membrane	NN
cord-291950-9gtsqyfj	234	11	.	.	.
cord-291950-9gtsqyfj	235	1	The	the	DT
cord-291950-9gtsqyfj	235	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	235	3	structure	structure	NN
cord-291950-9gtsqyfj	235	4	has	have	VBZ
cord-291950-9gtsqyfj	235	5	been	be	VBN
cord-291950-9gtsqyfj	235	6	solved	solve	VBN
cord-291950-9gtsqyfj	235	7	for	for	IN
cord-291950-9gtsqyfj	235	8	a	a	DT
cord-291950-9gtsqyfj	235	9	homolog	homolog	NN
cord-291950-9gtsqyfj	235	10	from	from	IN
cord-291950-9gtsqyfj	235	11	the	the	DT
cord-291950-9gtsqyfj	235	12	plant	plant	NN
cord-291950-9gtsqyfj	235	13	pathogen	pathogen	NN
cord-291950-9gtsqyfj	235	14	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	235	15	syringae	syringae	NN
cord-291950-9gtsqyfj	235	16	,	,	,
cord-291950-9gtsqyfj	235	17	which	which	WDT
cord-291950-9gtsqyfj	235	18	is	be	VBZ
cord-291950-9gtsqyfj	235	19	the	the	DT
cord-291950-9gtsqyfj	235	20	avirulence	avirulence	NNP
cord-291950-9gtsqyfj	235	21	protein	protein	NN
cord-291950-9gtsqyfj	235	22	AvrPphB	AvrPphB	NNP
cord-291950-9gtsqyfj	235	23	(	(	-LRB-
cord-291950-9gtsqyfj	235	24	see	see	VB
cord-291950-9gtsqyfj	235	25	Figure	Figure	NNP
cord-291950-9gtsqyfj	235	26	404	404	CD
cord-291950-9gtsqyfj	235	27	.	.	.
cord-291950-9gtsqyfj	235	28	16	16	CD
cord-291950-9gtsqyfj	235	29	)	)	-RRB-
cord-291950-9gtsqyfj	235	30	.	.	.
cord-291950-9gtsqyfj	236	1	The	the	DT
cord-291950-9gtsqyfj	236	2	only	only	JJ
cord-291950-9gtsqyfj	236	3	proteolytic	proteolytic	JJ
cord-291950-9gtsqyfj	236	4	activity	activity	NN
cord-291950-9gtsqyfj	236	5	that	that	WDT
cord-291950-9gtsqyfj	236	6	could	could	MD
cord-291950-9gtsqyfj	236	7	be	be	VB
cord-291950-9gtsqyfj	236	8	demonstrated	demonstrate	VBN
cord-291950-9gtsqyfj	236	9	was	be	VBD
cord-291950-9gtsqyfj	236	10	that	that	DT
cord-291950-9gtsqyfj	236	11	for	for	IN
cord-291950-9gtsqyfj	236	12	autocatalytic	autocatalytic	JJ
cord-291950-9gtsqyfj	236	13	activation	activation	NN
cord-291950-9gtsqyfj	236	14	of	of	IN
cord-291950-9gtsqyfj	236	15	the	the	DT
cord-291950-9gtsqyfj	236	16	precursor	precursor	NN
cord-291950-9gtsqyfj	236	17	protein	protein	NN
cord-291950-9gtsqyfj	236	18	.	.	.
cord-291950-9gtsqyfj	237	1	A	a	DT
cord-291950-9gtsqyfj	237	2	papain	papain	NN
cord-291950-9gtsqyfj	237	3	-	-	HYPH
cord-291950-9gtsqyfj	237	4	like	like	JJ
cord-291950-9gtsqyfj	237	5	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	237	6	triad	triad	NN
cord-291950-9gtsqyfj	237	7	(	(	-LRB-
cord-291950-9gtsqyfj	237	8	Cys/	Cys/	NNP
cord-291950-9gtsqyfj	237	9	His	-PRON-	PRP$
cord-291950-9gtsqyfj	237	10	/	/	SYM
cord-291950-9gtsqyfj	237	11	Asp	Asp	NNP
cord-291950-9gtsqyfj	237	12	)	)	-RRB-
cord-291950-9gtsqyfj	237	13	has	have	VBZ
cord-291950-9gtsqyfj	237	14	been	be	VBN
cord-291950-9gtsqyfj	237	15	identified	identify	VBN
cord-291950-9gtsqyfj	237	16	in	in	IN
cord-291950-9gtsqyfj	237	17	both	both	CC
cord-291950-9gtsqyfj	237	18	the	the	DT
cord-291950-9gtsqyfj	237	19	YopT	YopT	NNP
cord-291950-9gtsqyfj	237	20	effector	effector	NN
cord-291950-9gtsqyfj	237	21	and	and	CC
cord-291950-9gtsqyfj	237	22	the	the	DT
cord-291950-9gtsqyfj	237	23	AvrPphB	avrpphb	NN
cord-291950-9gtsqyfj	237	24	protein	protein	NN
cord-291950-9gtsqyfj	237	25	by	by	IN
cord-291950-9gtsqyfj	237	26	site	site	NN
cord-291950-9gtsqyfj	237	27	-	-	HYPH
cord-291950-9gtsqyfj	237	28	directed	direct	VBN
cord-291950-9gtsqyfj	237	29	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	237	30	.	.	.
cord-291950-9gtsqyfj	238	1	However	however	RB
cord-291950-9gtsqyfj	238	2	,	,	,
cord-291950-9gtsqyfj	238	3	there	there	EX
cord-291950-9gtsqyfj	238	4	does	do	VBZ
cord-291950-9gtsqyfj	238	5	not	not	RB
cord-291950-9gtsqyfj	238	6	appear	appear	VB
cord-291950-9gtsqyfj	238	7	to	to	TO
cord-291950-9gtsqyfj	238	8	be	be	VB
cord-291950-9gtsqyfj	238	9	a	a	DT
cord-291950-9gtsqyfj	238	10	conserved	conserved	JJ
cord-291950-9gtsqyfj	238	11	residue	residue	NN
cord-291950-9gtsqyfj	238	12	in	in	IN
cord-291950-9gtsqyfj	238	13	the	the	DT
cord-291950-9gtsqyfj	238	14	family	family	NN
cord-291950-9gtsqyfj	238	15	that	that	WDT
cord-291950-9gtsqyfj	238	16	would	would	MD
cord-291950-9gtsqyfj	238	17	act	act	VB
cord-291950-9gtsqyfj	238	18	like	like	IN
cord-291950-9gtsqyfj	238	19	Gln19	Gln19	NNP
cord-291950-9gtsqyfj	238	20	in	in	IN
cord-291950-9gtsqyfj	238	21	papain	papain	NN
cord-291950-9gtsqyfj	238	22	[	[	-LRB-
cord-291950-9gtsqyfj	238	23	36	36	CD
cord-291950-9gtsqyfj	238	24	]	]	-RRB-
cord-291950-9gtsqyfj	238	25	.	.	.
cord-291950-9gtsqyfj	239	1	Another	another	DT
cord-291950-9gtsqyfj	239	2	related	related	JJ
cord-291950-9gtsqyfj	239	3	peptidase	peptidase	NN
cord-291950-9gtsqyfj	239	4	from	from	IN
cord-291950-9gtsqyfj	239	5	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	239	6	syringae	syringae	NN
cord-291950-9gtsqyfj	239	7	,	,	,
cord-291950-9gtsqyfj	239	8	HopN1	HopN1	NNP
cord-291950-9gtsqyfj	239	9	is	be	VBZ
cord-291950-9gtsqyfj	239	10	a	a	DT
cord-291950-9gtsqyfj	239	11	virulence	virulence	NN
cord-291950-9gtsqyfj	239	12	factor	factor	NN
cord-291950-9gtsqyfj	239	13	and	and	CC
cord-291950-9gtsqyfj	239	14	is	be	VBZ
cord-291950-9gtsqyfj	239	15	injected	inject	VBN
cord-291950-9gtsqyfj	239	16	into	into	IN
cord-291950-9gtsqyfj	239	17	host	host	NN
cord-291950-9gtsqyfj	239	18	plant	plant	NN
cord-291950-9gtsqyfj	239	19	cells	cell	NNS
cord-291950-9gtsqyfj	239	20	by	by	IN
cord-291950-9gtsqyfj	239	21	a	a	DT
cord-291950-9gtsqyfj	239	22	type	type	NN
cord-291950-9gtsqyfj	239	23	III	iii	CD
cord-291950-9gtsqyfj	239	24	secretion	secretion	NN
cord-291950-9gtsqyfj	239	25	system	system	NN
cord-291950-9gtsqyfj	239	26	where	where	WRB
cord-291950-9gtsqyfj	239	27	is	be	VBZ
cord-291950-9gtsqyfj	239	28	suppresses	suppress	VBZ
cord-291950-9gtsqyfj	239	29	cell	cell	NN
cord-291950-9gtsqyfj	239	30	death	death	NN
cord-291950-9gtsqyfj	239	31	[	[	-LRB-
cord-291950-9gtsqyfj	239	32	37	37	CD
cord-291950-9gtsqyfj	239	33	]	]	-RRB-
cord-291950-9gtsqyfj	239	34	.	.	.
cord-291950-9gtsqyfj	240	1	The	the	DT
cord-291950-9gtsqyfj	240	2	HopN1	HopN1	NNP
cord-291950-9gtsqyfj	240	3	peptidase	peptidase	NN
cord-291950-9gtsqyfj	240	4	is	be	VBZ
cord-291950-9gtsqyfj	240	5	only	only	RB
cord-291950-9gtsqyfj	240	6	distantly	distantly	RB
cord-291950-9gtsqyfj	240	7	related	related	JJ
cord-291950-9gtsqyfj	240	8	and	and	CC
cord-291950-9gtsqyfj	240	9	consequently	consequently	RB
cord-291950-9gtsqyfj	240	10	,	,	,
cord-291950-9gtsqyfj	240	11	family	family	NN
cord-291950-9gtsqyfj	240	12	C58	C58	NNP
cord-291950-9gtsqyfj	240	13	is	be	VBZ
cord-291950-9gtsqyfj	240	14	divided	divide	VBN
cord-291950-9gtsqyfj	240	15	into	into	IN
cord-291950-9gtsqyfj	240	16	two	two	CD
cord-291950-9gtsqyfj	240	17	subfamilies	subfamily	NNS
cord-291950-9gtsqyfj	240	18	with	with	IN
cord-291950-9gtsqyfj	240	19	YopT	YopT	NNP
cord-291950-9gtsqyfj	240	20	and	and	CC
cord-291950-9gtsqyfj	240	21	AvrPphB	AvrPphB	NNP
cord-291950-9gtsqyfj	240	22	members	member	NNS
cord-291950-9gtsqyfj	240	23	of	of	IN
cord-291950-9gtsqyfj	240	24	subfamily	subfamily	NN
cord-291950-9gtsqyfj	240	25	C58A	C58A	.
cord-291950-9gtsqyfj	240	26	and	and	CC
cord-291950-9gtsqyfj	240	27	HopN1	HopN1	NNP
cord-291950-9gtsqyfj	240	28	in	in	IN
cord-291950-9gtsqyfj	240	29	C58B.	C58B.	NNS
cord-291950-9gtsqyfj	241	1	The	the	DT
cord-291950-9gtsqyfj	241	2	IdeS	IdeS	NNP
cord-291950-9gtsqyfj	241	3	peptidase	peptidase	NN
cord-291950-9gtsqyfj	241	4	(	(	-LRB-
cord-291950-9gtsqyfj	241	5	Chapter	chapter	NN
cord-291950-9gtsqyfj	241	6	489	489	CD
cord-291950-9gtsqyfj	241	7	)	)	-RRB-
cord-291950-9gtsqyfj	241	8	from	from	IN
cord-291950-9gtsqyfj	241	9	Streptococcus	streptococcus	NN
cord-291950-9gtsqyfj	241	10	pyogenes	pyogene	NNS
cord-291950-9gtsqyfj	241	11	is	be	VBZ
cord-291950-9gtsqyfj	241	12	included	include	VBN
cord-291950-9gtsqyfj	241	13	in	in	IN
cord-291950-9gtsqyfj	241	14	family	family	NN
cord-291950-9gtsqyfj	241	15	C66	C66	NNP
cord-291950-9gtsqyfj	241	16	.	.	.
cord-291950-9gtsqyfj	242	1	This	this	DT
cord-291950-9gtsqyfj	242	2	peptidase	peptidase	NN
cord-291950-9gtsqyfj	242	3	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	242	4	the	the	DT
cord-291950-9gtsqyfj	242	5	γ	γ	NN
cord-291950-9gtsqyfj	242	6	-	-	HYPH
cord-291950-9gtsqyfj	242	7	chains	chain	NNS
cord-291950-9gtsqyfj	242	8	of	of	IN
cord-291950-9gtsqyfj	242	9	human	human	NN
cord-291950-9gtsqyfj	243	1	IgG.	IgG.	NNP
cord-291950-9gtsqyfj	244	1	From	from	IN
cord-291950-9gtsqyfj	244	2	the	the	DT
cord-291950-9gtsqyfj	244	3	crystal	crystal	NN
cord-291950-9gtsqyfj	244	4	structure	structure	NN
cord-291950-9gtsqyfj	244	5	[	[	-LRB-
cord-291950-9gtsqyfj	244	6	38	38	CD
cord-291950-9gtsqyfj	244	7	]	]	-RRB-
cord-291950-9gtsqyfj	244	8	,	,	,
cord-291950-9gtsqyfj	244	9	a	a	DT
cord-291950-9gtsqyfj	244	10	papain	papain	NN
cord-291950-9gtsqyfj	244	11	-	-	HYPH
cord-291950-9gtsqyfj	244	12	like	like	JJ
cord-291950-9gtsqyfj	244	13	fold	fold	NN
cord-291950-9gtsqyfj	244	14	is	be	VBZ
cord-291950-9gtsqyfj	244	15	apparent	apparent	JJ
cord-291950-9gtsqyfj	244	16	and	and	CC
cord-291950-9gtsqyfj	244	17	a	a	DT
cord-291950-9gtsqyfj	244	18	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	244	19	triad	triad	NN
cord-291950-9gtsqyfj	244	20	consisting	consisting	NN
cord-291950-9gtsqyfj	244	21	of	of	IN
cord-291950-9gtsqyfj	244	22	Cys94	Cys94	NNP
cord-291950-9gtsqyfj	244	23	,	,	,
cord-291950-9gtsqyfj	244	24	His262	his262	CD
cord-291950-9gtsqyfj	244	25	and	and	CC
cord-291950-9gtsqyfj	244	26	Asp284	Asp284	NFP
cord-291950-9gtsqyfj	244	27	(	(	-LRB-
cord-291950-9gtsqyfj	244	28	see	see	VB
cord-291950-9gtsqyfj	244	29	Figure	Figure	NNP
cord-291950-9gtsqyfj	244	30	404	404	CD
cord-291950-9gtsqyfj	244	31	.17	.17	CD
cord-291950-9gtsqyfj	244	32	)	)	-RRB-
cord-291950-9gtsqyfj	244	33	.	.	.
cord-291950-9gtsqyfj	245	1	Family	Family	NNP
cord-291950-9gtsqyfj	245	2	C83	C83	NNP
cord-291950-9gtsqyfj	245	3	includes	include	VBZ
cord-291950-9gtsqyfj	245	4	phytochelatin	phytochelatin	NN
cord-291950-9gtsqyfj	245	5	synthases	synthase	NNS
cord-291950-9gtsqyfj	245	6	(	(	-LRB-
cord-291950-9gtsqyfj	245	7	Chapter	chapter	NN
cord-291950-9gtsqyfj	245	8	490	490	CD
cord-291950-9gtsqyfj	245	9	)	)	-RRB-
cord-291950-9gtsqyfj	245	10	,	,	,
cord-291950-9gtsqyfj	245	11	which	which	WDT
cord-291950-9gtsqyfj	245	12	are	be	VBP
cord-291950-9gtsqyfj	245	13	γ	γ	NN
cord-291950-9gtsqyfj	245	14	-	-	HYPH
cord-291950-9gtsqyfj	245	15	glutamylcysteine	glutamylcysteine	JJ
cord-291950-9gtsqyfj	245	16	dipeptidyltranspeptidases	dipeptidyltranspeptidase	NNS
cord-291950-9gtsqyfj	245	17	,	,	,
cord-291950-9gtsqyfj	245	18	from	from	IN
cord-291950-9gtsqyfj	245	19	cyanobacteria	cyanobacteria	NNS
cord-291950-9gtsqyfj	245	20	and	and	CC
cord-291950-9gtsqyfj	245	21	plants	plant	NNS
cord-291950-9gtsqyfj	245	22	.	.	.
cord-291950-9gtsqyfj	246	1	These	these	DT
cord-291950-9gtsqyfj	246	2	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	246	3	remove	remove	VBP
cord-291950-9gtsqyfj	246	4	the	the	DT
cord-291950-9gtsqyfj	246	5	C	c	NN
cord-291950-9gtsqyfj	246	6	-	-	HYPH
cord-291950-9gtsqyfj	246	7	terminal	terminal	NN
cord-291950-9gtsqyfj	246	8	Gly	Gly	NNP
cord-291950-9gtsqyfj	246	9	from	from	IN
cord-291950-9gtsqyfj	246	10	glutathione	glutathione	NN
cord-291950-9gtsqyfj	246	11	(	(	-LRB-
cord-291950-9gtsqyfj	246	12	γ	γ	NNP
cord-291950-9gtsqyfj	246	13	-	-	HYPH
cord-291950-9gtsqyfj	246	14	Glu	Glu	NNP
cord-291950-9gtsqyfj	246	15	-	-	HYPH
cord-291950-9gtsqyfj	246	16	Cys	Cys	NNP
cord-291950-9gtsqyfj	246	17	-	-	HYPH
cord-291950-9gtsqyfj	246	18	Gly	Gly	NNP
cord-291950-9gtsqyfj	246	19	)	)	-RRB-
cord-291950-9gtsqyfj	246	20	.	.	.
cord-291950-9gtsqyfj	247	1	This	this	DT
cord-291950-9gtsqyfj	247	2	is	be	VBZ
cord-291950-9gtsqyfj	247	3	in	in	IN
cord-291950-9gtsqyfj	247	4	contrast	contrast	NN
cord-291950-9gtsqyfj	247	5	to	to	IN
cord-291950-9gtsqyfj	247	6	the	the	DT
cord-291950-9gtsqyfj	247	7	action	action	NN
cord-291950-9gtsqyfj	247	8	of	of	IN
cord-291950-9gtsqyfj	247	9	the	the	DT
cord-291950-9gtsqyfj	247	10	γ	γ	NNP
cord-291950-9gtsqyfj	247	11	-	-	HYPH
cord-291950-9gtsqyfj	247	12	glutamyltransferases	glutamyltransferases	NNP
cord-291950-9gtsqyfj	247	13	(	(	-LRB-
cord-291950-9gtsqyfj	247	14	Chapter	chapter	NN
cord-291950-9gtsqyfj	247	15	820	820	CD
cord-291950-9gtsqyfj	247	16	)	)	-RRB-
cord-291950-9gtsqyfj	247	17	that	that	WDT
cord-291950-9gtsqyfj	247	18	remove	remove	VBP
cord-291950-9gtsqyfj	247	19	the	the	DT
cord-291950-9gtsqyfj	247	20	N	n	CD
cord-291950-9gtsqyfj	247	21	-	-	HYPH
cord-291950-9gtsqyfj	247	22	terminal	terminal	NN
cord-291950-9gtsqyfj	247	23	residue	residue	NN
cord-291950-9gtsqyfj	247	24	.	.	.
cord-291950-9gtsqyfj	248	1	Removal	removal	NN
cord-291950-9gtsqyfj	248	2	of	of	IN
cord-291950-9gtsqyfj	248	3	the	the	DT
cord-291950-9gtsqyfj	248	4	C	c	NN
cord-291950-9gtsqyfj	248	5	-	-	HYPH
cord-291950-9gtsqyfj	248	6	terminal	terminal	NN
cord-291950-9gtsqyfj	248	7	Gly	Gly	NNP
cord-291950-9gtsqyfj	248	8	is	be	VBZ
cord-291950-9gtsqyfj	248	9	an	an	DT
cord-291950-9gtsqyfj	248	10	important	important	JJ
cord-291950-9gtsqyfj	248	11	step	step	NN
cord-291950-9gtsqyfj	248	12	towards	towards	IN
cord-291950-9gtsqyfj	248	13	formation	formation	NN
cord-291950-9gtsqyfj	248	14	of	of	IN
cord-291950-9gtsqyfj	248	15	phytochelatin	phytochelatin	NN
cord-291950-9gtsqyfj	248	16	from	from	IN
cord-291950-9gtsqyfj	248	17	linear	linear	JJ
cord-291950-9gtsqyfj	248	18	polymers	polymer	NNS
cord-291950-9gtsqyfj	248	19	of	of	IN
cord-291950-9gtsqyfj	248	20	the	the	DT
cord-291950-9gtsqyfj	248	21	γ	γ	NNP
cord-291950-9gtsqyfj	248	22	-	-	HYPH
cord-291950-9gtsqyfj	248	23	Glu	Glu	NNP
cord-291950-9gtsqyfj	248	24	-	-	HYPH
cord-291950-9gtsqyfj	248	25	Cys	Cys	NNP
cord-291950-9gtsqyfj	248	26	,	,	,
cord-291950-9gtsqyfj	248	27	and	and	CC
cord-291950-9gtsqyfj	248	28	phytochelatin	phytochelatin	NNP
cord-291950-9gtsqyfj	248	29	is	be	VBZ
cord-291950-9gtsqyfj	248	30	important	important	JJ
cord-291950-9gtsqyfj	248	31	because	because	IN
cord-291950-9gtsqyfj	248	32	ions	ion	NNS
cord-291950-9gtsqyfj	248	33	of	of	IN
cord-291950-9gtsqyfj	248	34	heavy	heavy	JJ
cord-291950-9gtsqyfj	248	35	metal	metal	NN
cord-291950-9gtsqyfj	248	36	ions	ion	NNS
cord-291950-9gtsqyfj	248	37	such	such	JJ
cord-291950-9gtsqyfj	248	38	as	as	IN
cord-291950-9gtsqyfj	248	39	mercury	mercury	NN
cord-291950-9gtsqyfj	248	40	and	and	CC
cord-291950-9gtsqyfj	248	41	cadmium	cadmium	NN
cord-291950-9gtsqyfj	248	42	are	be	VBP
cord-291950-9gtsqyfj	248	43	rendered	render	VBN
cord-291950-9gtsqyfj	248	44	harmless	harmless	JJ
cord-291950-9gtsqyfj	248	45	by	by	IN
cord-291950-9gtsqyfj	248	46	forming	form	VBG
cord-291950-9gtsqyfj	248	47	tight	tight	JJ
cord-291950-9gtsqyfj	248	48	complexes	complex	NNS
cord-291950-9gtsqyfj	248	49	with	with	IN
cord-291950-9gtsqyfj	248	50	phytochelatin	phytochelatin	NNS
cord-291950-9gtsqyfj	248	51	.	.	.
cord-291950-9gtsqyfj	249	1	The	the	DT
cord-291950-9gtsqyfj	249	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	249	3	structure	structure	NN
cord-291950-9gtsqyfj	249	4	of	of	IN
cord-291950-9gtsqyfj	249	5	γ	γ	NN
cord-291950-9gtsqyfj	249	6	-	-	HYPH
cord-291950-9gtsqyfj	249	7	glutamylcysteine	glutamylcysteine	JJ
cord-291950-9gtsqyfj	249	8	dipeptidyltranspeptidase	dipeptidyltranspeptidase	NN
cord-291950-9gtsqyfj	249	9	from	from	IN
cord-291950-9gtsqyfj	249	10	the	the	DT
cord-291950-9gtsqyfj	249	11	cyanobacterium	cyanobacterium	NN
cord-291950-9gtsqyfj	249	12	Nostoc	Nostoc	NNP
cord-291950-9gtsqyfj	249	13	sp	sp	NN
cord-291950-9gtsqyfj	249	14	.	.	.
cord-291950-9gtsqyfj	250	1	PCC	PCC	NNP
cord-291950-9gtsqyfj	250	2	7120	7120	CD
cord-291950-9gtsqyfj	250	3	has	have	VBZ
cord-291950-9gtsqyfj	250	4	been	be	VBN
cord-291950-9gtsqyfj	250	5	solved	solve	VBN
cord-291950-9gtsqyfj	250	6	,	,	,
cord-291950-9gtsqyfj	250	7	and	and	CC
cord-291950-9gtsqyfj	250	8	shows	show	VBZ
cord-291950-9gtsqyfj	250	9	a	a	DT
cord-291950-9gtsqyfj	250	10	papain	papain	NN
cord-291950-9gtsqyfj	250	11	-	-	HYPH
cord-291950-9gtsqyfj	250	12	like	like	JJ
cord-291950-9gtsqyfj	250	13	fold	fold	NN
cord-291950-9gtsqyfj	250	14	and	and	CC
cord-291950-9gtsqyfj	250	15	an	an	DT
cord-291950-9gtsqyfj	250	16	active	active	JJ
cord-291950-9gtsqyfj	250	17	site	site	NN
cord-291950-9gtsqyfj	250	18	also	also	RB
cord-291950-9gtsqyfj	250	19	similar	similar	JJ
cord-291950-9gtsqyfj	250	20	to	to	IN
cord-291950-9gtsqyfj	250	21	that	that	DT
cord-291950-9gtsqyfj	250	22	of	of	IN
cord-291950-9gtsqyfj	250	23	papain	papain	NN
cord-291950-9gtsqyfj	250	24	,	,	,
cord-291950-9gtsqyfj	250	25	containing	contain	VBG
cord-291950-9gtsqyfj	250	26	Gln	Gln	NNP
cord-291950-9gtsqyfj	250	27	,	,	,
cord-291950-9gtsqyfj	250	28	Cys	Cys	NNP
cord-291950-9gtsqyfj	250	29	,	,	,
cord-291950-9gtsqyfj	250	30	His	His	NNP
cord-291950-9gtsqyfj	250	31	and	and	CC
cord-291950-9gtsqyfj	250	32	Asp	Asp	NNP
cord-291950-9gtsqyfj	250	33	[	[	-LRB-
cord-291950-9gtsqyfj	250	34	39	39	CD
cord-291950-9gtsqyfj	250	35	]	]	-RRB-
cord-291950-9gtsqyfj	250	36	(	(	-LRB-
cord-291950-9gtsqyfj	250	37	see	see	VB
cord-291950-9gtsqyfj	250	38	Figure	figure	NN
cord-291950-9gtsqyfj	250	39	404	404	CD
cord-291950-9gtsqyfj	250	40	.18	.18	NFP
cord-291950-9gtsqyfj	250	41	)	)	-RRB-
cord-291950-9gtsqyfj	250	42	.	.	.
cord-291950-9gtsqyfj	251	1	The	the	DT
cord-291950-9gtsqyfj	251	2	'	'	``
cord-291950-9gtsqyfj	251	3	papain	papain	NN
cord-291950-9gtsqyfj	251	4	-	-	HYPH
cord-291950-9gtsqyfj	251	5	like	like	JJ
cord-291950-9gtsqyfj	251	6	'	'	''
cord-291950-9gtsqyfj	251	7	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	251	8	of	of	IN
cord-291950-9gtsqyfj	251	9	RNA	RNA	NNP
cord-291950-9gtsqyfj	251	10	viruses	virus	NNS
cord-291950-9gtsqyfj	251	11	form	form	VBP
cord-291950-9gtsqyfj	251	12	a	a	DT
cord-291950-9gtsqyfj	251	13	large	large	JJ
cord-291950-9gtsqyfj	251	14	group	group	NN
cord-291950-9gtsqyfj	251	15	of	of	IN
cord-291950-9gtsqyfj	251	16	cysteine	cysteine	NN
cord-291950-9gtsqyfj	251	17	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	251	18	that	that	WDT
cord-291950-9gtsqyfj	251	19	contain	contain	VBP
cord-291950-9gtsqyfj	251	20	the	the	DT
cord-291950-9gtsqyfj	251	21	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	251	22	dyad	dyad	NN
cord-291950-9gtsqyfj	251	23	residues	residue	NNS
cord-291950-9gtsqyfj	251	24	in	in	IN
cord-291950-9gtsqyfj	251	25	the	the	DT
cord-291950-9gtsqyfj	251	26	order	order	NN
cord-291950-9gtsqyfj	252	1	Cys	Cys	NNP
cord-291950-9gtsqyfj	252	2	,	,	,
cord-291950-9gtsqyfj	252	3	His	-PRON-	PRP$
cord-291950-9gtsqyfj	252	4	.	.	.
cord-291950-9gtsqyfj	253	1	All	all	DT
cord-291950-9gtsqyfj	253	2	of	of	IN
cord-291950-9gtsqyfj	253	3	the	the	DT
cord-291950-9gtsqyfj	253	4	families	family	NNS
cord-291950-9gtsqyfj	253	5	had	have	VBD
cord-291950-9gtsqyfj	253	6	been	be	VBN
cord-291950-9gtsqyfj	253	7	included	include	VBN
cord-291950-9gtsqyfj	253	8	in	in	IN
cord-291950-9gtsqyfj	253	9	clan	clan	NN
cord-291950-9gtsqyfj	253	10	CA	CA	NNP
cord-291950-9gtsqyfj	253	11	,	,	,
cord-291950-9gtsqyfj	253	12	even	even	RB
cord-291950-9gtsqyfj	253	13	though	though	IN
cord-291950-9gtsqyfj	253	14	for	for	IN
cord-291950-9gtsqyfj	253	15	many	many	JJ
cord-291950-9gtsqyfj	253	16	no	no	DT
cord-291950-9gtsqyfj	253	17	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	253	18	structure	structure	NN
cord-291950-9gtsqyfj	253	19	for	for	IN
cord-291950-9gtsqyfj	253	20	any	any	DT
cord-291950-9gtsqyfj	253	21	member	member	NN
cord-291950-9gtsqyfj	253	22	had	have	VBD
cord-291950-9gtsqyfj	253	23	been	be	VBN
cord-291950-9gtsqyfj	253	24	solved	solve	VBN
cord-291950-9gtsqyfj	253	25	.	.	.
cord-291950-9gtsqyfj	254	1	When	when	WRB
cord-291950-9gtsqyfj	254	2	the	the	DT
cord-291950-9gtsqyfj	254	3	crystal	crystal	JJ
cord-291950-9gtsqyfj	254	4	structure	structure	NN
cord-291950-9gtsqyfj	254	5	of	of	IN
cord-291950-9gtsqyfj	254	6	the	the	DT
cord-291950-9gtsqyfj	254	7	nsP2	nsp2	NN
cord-291950-9gtsqyfj	254	8	(	(	-LRB-
cord-291950-9gtsqyfj	254	9	nonstructural	nonstructural	JJ
cord-291950-9gtsqyfj	254	10	protein	protein	NNP
cord-291950-9gtsqyfj	254	11	2	2	CD
cord-291950-9gtsqyfj	254	12	)	)	-RRB-
cord-291950-9gtsqyfj	254	13	from	from	IN
cord-291950-9gtsqyfj	254	14	Sindbis	Sindbis	NNP
cord-291950-9gtsqyfj	254	15	virus	virus	NN
cord-291950-9gtsqyfj	254	16	(	(	-LRB-
cord-291950-9gtsqyfj	254	17	a	a	DT
cord-291950-9gtsqyfj	254	18	member	member	NN
cord-291950-9gtsqyfj	254	19	of	of	IN
cord-291950-9gtsqyfj	254	20	family	family	NN
cord-291950-9gtsqyfj	254	21	C9	C9	NNP
cord-291950-9gtsqyfj	254	22	)	)	-RRB-
cord-291950-9gtsqyfj	254	23	was	be	VBD
cord-291950-9gtsqyfj	254	24	determined	determine	VBN
cord-291950-9gtsqyfj	254	25	,	,	,
cord-291950-9gtsqyfj	254	26	the	the	DT
cord-291950-9gtsqyfj	254	27	fold	fold	NN
cord-291950-9gtsqyfj	254	28	was	be	VBD
cord-291950-9gtsqyfj	254	29	quite	quite	RB
cord-291950-9gtsqyfj	254	30	unlike	unlike	IN
cord-291950-9gtsqyfj	254	31	that	that	DT
cord-291950-9gtsqyfj	254	32	of	of	IN
cord-291950-9gtsqyfj	254	33	papain	papain	NN
cord-291950-9gtsqyfj	254	34	,	,	,
cord-291950-9gtsqyfj	254	35	and	and	CC
cord-291950-9gtsqyfj	254	36	the	the	DT
cord-291950-9gtsqyfj	254	37	family	family	NN
cord-291950-9gtsqyfj	254	38	was	be	VBD
cord-291950-9gtsqyfj	254	39	assigned	assign	VBN
cord-291950-9gtsqyfj	254	40	to	to	IN
cord-291950-9gtsqyfj	254	41	its	-PRON-	PRP$
cord-291950-9gtsqyfj	254	42	own	own	JJ
cord-291950-9gtsqyfj	254	43	clan	clan	NN
cord-291950-9gtsqyfj	254	44	(	(	-LRB-
cord-291950-9gtsqyfj	254	45	CN	CN	NNP
cord-291950-9gtsqyfj	254	46	,	,	,
cord-291950-9gtsqyfj	254	47	see	see	VB
cord-291950-9gtsqyfj	254	48	below	below	RB
cord-291950-9gtsqyfj	254	49	)	)	-RRB-
cord-291950-9gtsqyfj	254	50	.	.	.
cord-291950-9gtsqyfj	255	1	Consequently	consequently	RB
cord-291950-9gtsqyfj	255	2	,	,	,
cord-291950-9gtsqyfj	255	3	many	many	JJ
cord-291950-9gtsqyfj	255	4	families	family	NNS
cord-291950-9gtsqyfj	255	5	of	of	IN
cord-291950-9gtsqyfj	255	6	peptidases	peptidases	NNPS
cord-291950-9gtsqyfj	255	7	from	from	IN
cord-291950-9gtsqyfj	255	8	RNA	RNA	NNP
cord-291950-9gtsqyfj	255	9	viruses	virus	NNS
cord-291950-9gtsqyfj	255	10	that	that	WDT
cord-291950-9gtsqyfj	255	11	had	have	VBD
cord-291950-9gtsqyfj	255	12	been	be	VBN
cord-291950-9gtsqyfj	255	13	included	include	VBN
cord-291950-9gtsqyfj	255	14	in	in	IN
cord-291950-9gtsqyfj	255	15	clan	clan	NN
cord-291950-9gtsqyfj	255	16	CA	CA	NNP
cord-291950-9gtsqyfj	255	17	have	have	VBP
cord-291950-9gtsqyfj	255	18	been	be	VBN
cord-291950-9gtsqyfj	255	19	removed	remove	VBN
cord-291950-9gtsqyfj	255	20	,	,	,
cord-291950-9gtsqyfj	255	21	because	because	IN
cord-291950-9gtsqyfj	255	22	until	until	IN
cord-291950-9gtsqyfj	255	23	a	a	DT
cord-291950-9gtsqyfj	255	24	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	255	25	structure	structure	NN
cord-291950-9gtsqyfj	255	26	has	have	VBZ
cord-291950-9gtsqyfj	255	27	been	be	VBN
cord-291950-9gtsqyfj	255	28	solved	solve	VBN
cord-291950-9gtsqyfj	255	29	it	-PRON-	PRP
cord-291950-9gtsqyfj	255	30	will	will	MD
cord-291950-9gtsqyfj	255	31	not	not	RB
cord-291950-9gtsqyfj	255	32	be	be	VB
cord-291950-9gtsqyfj	255	33	possible	possible	JJ
cord-291950-9gtsqyfj	255	34	from	from	IN
cord-291950-9gtsqyfj	255	35	sequence	sequence	NN
cord-291950-9gtsqyfj	255	36	alone	alone	JJ
cord-291950-9gtsqyfj	255	37	to	to	TO
cord-291950-9gtsqyfj	255	38	determine	determine	VB
cord-291950-9gtsqyfj	255	39	if	if	IN
cord-291950-9gtsqyfj	255	40	any	any	DT
cord-291950-9gtsqyfj	255	41	of	of	IN
cord-291950-9gtsqyfj	255	42	these	these	DT
cord-291950-9gtsqyfj	255	43	families	family	NNS
cord-291950-9gtsqyfj	255	44	belongs	belong	VBZ
cord-291950-9gtsqyfj	255	45	to	to	TO
cord-291950-9gtsqyfj	255	46	clan	clan	VB
cord-291950-9gtsqyfj	255	47	CA	CA	NNP
cord-291950-9gtsqyfj	255	48	or	or	CC
cord-291950-9gtsqyfj	255	49	clan	clan	NN
cord-291950-9gtsqyfj	255	50	CN	CN	NNP
cord-291950-9gtsqyfj	255	51	.	.	.
cord-291950-9gtsqyfj	256	1	The	the	DT
cord-291950-9gtsqyfj	256	2	families	family	NNS
cord-291950-9gtsqyfj	256	3	of	of	IN
cord-291950-9gtsqyfj	256	4	RNA	RNA	NNP
cord-291950-9gtsqyfj	256	5	viruses	virus	NNS
cord-291950-9gtsqyfj	256	6	retained	retain	VBN
cord-291950-9gtsqyfj	256	7	in	in	IN
cord-291950-9gtsqyfj	256	8	clan	clan	NN
cord-291950-9gtsqyfj	256	9	CA	CA	NNP
cord-291950-9gtsqyfj	256	10	,	,	,
cord-291950-9gtsqyfj	256	11	and	and	CC
cord-291950-9gtsqyfj	256	12	for	for	IN
cord-291950-9gtsqyfj	256	13	which	which	WDT
cord-291950-9gtsqyfj	256	14	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	256	15	structures	structure	NNS
cord-291950-9gtsqyfj	256	16	have	have	VBP
cord-291950-9gtsqyfj	256	17	been	be	VBN
cord-291950-9gtsqyfj	256	18	solved	solve	VBN
cord-291950-9gtsqyfj	256	19	,	,	,
cord-291950-9gtsqyfj	256	20	are	be	VBP
cord-291950-9gtsqyfj	256	21	C28	C28	NNP
cord-291950-9gtsqyfj	256	22	,	,	,
cord-291950-9gtsqyfj	256	23	C31	C31	NNP
cord-291950-9gtsqyfj	256	24	,	,	,
cord-291950-9gtsqyfj	256	25	C32	C32	NNP
cord-291950-9gtsqyfj	256	26	and	and	CC
cord-291950-9gtsqyfj	256	27	C87	C87	NNP
cord-291950-9gtsqyfj	256	28	.	.	.
cord-291950-9gtsqyfj	257	1	Each	each	DT
cord-291950-9gtsqyfj	257	2	family	family	NN
cord-291950-9gtsqyfj	257	3	contains	contain	VBZ
cord-291950-9gtsqyfj	257	4	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	257	5	from	from	IN
cord-291950-9gtsqyfj	257	6	only	only	RB
cord-291950-9gtsqyfj	257	7	one	one	CD
cord-291950-9gtsqyfj	257	8	family	family	NN
cord-291950-9gtsqyfj	257	9	of	of	IN
cord-291950-9gtsqyfj	257	10	viruses	virus	NNS
cord-291950-9gtsqyfj	257	11	.	.	.
cord-291950-9gtsqyfj	258	1	Thus	thus	RB
cord-291950-9gtsqyfj	258	2	,	,	,
cord-291950-9gtsqyfj	258	3	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	258	4	from	from	IN
cord-291950-9gtsqyfj	258	5	aphthoviruses	aphthoviruse	NNS
cord-291950-9gtsqyfj	258	6	are	be	VBP
cord-291950-9gtsqyfj	258	7	in	in	IN
cord-291950-9gtsqyfj	258	8	family	family	NN
cord-291950-9gtsqyfj	258	9	C28	c28	NN
cord-291950-9gtsqyfj	258	10	;	;	:
cord-291950-9gtsqyfj	258	11	arteriviruses	arteriviruse	NNS
cord-291950-9gtsqyfj	258	12	in	in	IN
cord-291950-9gtsqyfj	258	13	C31	C31	NNP
cord-291950-9gtsqyfj	258	14	and	and	CC
cord-291950-9gtsqyfj	258	15	C32	C32	NNP
cord-291950-9gtsqyfj	258	16	,	,	,
cord-291950-9gtsqyfj	258	17	and	and	CC
cord-291950-9gtsqyfj	258	18	nairoviruses	nairoviruse	NNS
cord-291950-9gtsqyfj	258	19	in	in	IN
cord-291950-9gtsqyfj	258	20	C87	C87	NNP
cord-291950-9gtsqyfj	258	21	.	.	.
cord-291950-9gtsqyfj	259	1	The	the	DT
cord-291950-9gtsqyfj	259	2	cleavages	cleavage	NNS
cord-291950-9gtsqyfj	259	3	mediated	mediate	VBN
cord-291950-9gtsqyfj	259	4	by	by	IN
cord-291950-9gtsqyfj	259	5	the	the	DT
cord-291950-9gtsqyfj	259	6	clan	clan	NN
cord-291950-9gtsqyfj	259	7	CA	CA	NNP
cord-291950-9gtsqyfj	259	8	viral	viral	JJ
cord-291950-9gtsqyfj	259	9	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	259	10	usually	usually	RB
cord-291950-9gtsqyfj	259	11	show	show	VBP
cord-291950-9gtsqyfj	259	12	Gly	Gly	NNP
cord-291950-9gtsqyfj	259	13	in	in	IN
cord-291950-9gtsqyfj	259	14	P1	P1	NNP
cord-291950-9gtsqyfj	259	15	(	(	-LRB-
cord-291950-9gtsqyfj	259	16	contrasting	contrast	VBG
cord-291950-9gtsqyfj	259	17	with	with	IN
cord-291950-9gtsqyfj	259	18	Gln	Gln	NNP
cord-291950-9gtsqyfj	259	19	in	in	IN
cord-291950-9gtsqyfj	259	20	P1	P1	NNP
cord-291950-9gtsqyfj	259	21	for	for	IN
cord-291950-9gtsqyfj	259	22	many	many	JJ
cord-291950-9gtsqyfj	259	23	cleavages	cleavage	NNS
cord-291950-9gtsqyfj	259	24	by	by	IN
cord-291950-9gtsqyfj	259	25	clan	clan	NN
cord-291950-9gtsqyfj	259	26	PA(C	pa(c	CD
cord-291950-9gtsqyfj	259	27	)	)	-RRB-
cord-291950-9gtsqyfj	259	28	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	259	29	)	)	-RRB-
cord-291950-9gtsqyfj	259	30	.	.	.
cord-291950-9gtsqyfj	260	1	In	in	IN
cord-291950-9gtsqyfj	260	2	most	most	JJS
cord-291950-9gtsqyfj	260	3	of	of	IN
cord-291950-9gtsqyfj	260	4	these	these	DT
cord-291950-9gtsqyfj	260	5	viruses	virus	NNS
cord-291950-9gtsqyfj	260	6	there	there	EX
cord-291950-9gtsqyfj	260	7	is	be	VBZ
cord-291950-9gtsqyfj	260	8	a	a	DT
cord-291950-9gtsqyfj	260	9	single	single	JJ
cord-291950-9gtsqyfj	260	10	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	260	11	containing	contain	VBG
cord-291950-9gtsqyfj	260	12	a	a	DT
cord-291950-9gtsqyfj	260	13	single	single	JJ
cord-291950-9gtsqyfj	260	14	peptidase	peptidase	NN
cord-291950-9gtsqyfj	260	15	,	,	,
cord-291950-9gtsqyfj	260	16	but	but	CC
cord-291950-9gtsqyfj	260	17	there	there	EX
cord-291950-9gtsqyfj	260	18	may	may	MD
cord-291950-9gtsqyfj	260	19	be	be	VB
cord-291950-9gtsqyfj	260	20	up	up	IN
cord-291950-9gtsqyfj	260	21	to	to	TO
cord-291950-9gtsqyfj	260	22	three	three	CD
cord-291950-9gtsqyfj	260	23	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	260	24	in	in	IN
cord-291950-9gtsqyfj	260	25	a	a	DT
cord-291950-9gtsqyfj	260	26	single	single	JJ
cord-291950-9gtsqyfj	260	27	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	260	28	.	.	.
cord-291950-9gtsqyfj	261	1	In	in	IN
cord-291950-9gtsqyfj	261	2	the	the	DT
cord-291950-9gtsqyfj	261	3	foot	foot	NN
cord-291950-9gtsqyfj	261	4	-	-	HYPH
cord-291950-9gtsqyfj	261	5	andmouth	andmouth	NNP
cord-291950-9gtsqyfj	261	6	disease	disease	NN
cord-291950-9gtsqyfj	261	7	virus	virus	NN
cord-291950-9gtsqyfj	261	8	,	,	,
cord-291950-9gtsqyfj	261	9	potyviruses	potyviruses	NNP
cord-291950-9gtsqyfj	261	10	and	and	CC
cord-291950-9gtsqyfj	261	11	togaviruses	togaviruses	NNP
cord-291950-9gtsqyfj	261	12	,	,	,
cord-291950-9gtsqyfj	261	13	the	the	DT
cord-291950-9gtsqyfj	261	14	other	other	JJ
cord-291950-9gtsqyfj	261	15	cysteine	cysteine	NN
cord-291950-9gtsqyfj	261	16	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	261	17	are	be	VBP
cord-291950-9gtsqyfj	261	18	not	not	RB
cord-291950-9gtsqyfj	261	19	related	relate	VBN
cord-291950-9gtsqyfj	261	20	to	to	IN
cord-291950-9gtsqyfj	261	21	papain	papain	NN
cord-291950-9gtsqyfj	261	22	(	(	-LRB-
cord-291950-9gtsqyfj	261	23	having	have	VBG
cord-291950-9gtsqyfj	261	24	the	the	DT
cord-291950-9gtsqyfj	261	25	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	261	26	dyad	dyad	NN
cord-291950-9gtsqyfj	261	27	in	in	IN
cord-291950-9gtsqyfj	261	28	the	the	DT
cord-291950-9gtsqyfj	261	29	order	order	NN
cord-291950-9gtsqyfj	261	30	His	-PRON-	PRP$
cord-291950-9gtsqyfj	261	31	,	,	,
cord-291950-9gtsqyfj	261	32	Cys	Cys	NNP
cord-291950-9gtsqyfj	261	33	)	)	-RRB-
cord-291950-9gtsqyfj	261	34	.	.	.
cord-291950-9gtsqyfj	262	1	In	in	IN
cord-291950-9gtsqyfj	262	2	the	the	DT
cord-291950-9gtsqyfj	262	3	coronaviruses	coronaviruse	NNS
cord-291950-9gtsqyfj	262	4	and	and	CC
cord-291950-9gtsqyfj	262	5	arteriviruses	arteriviruse	NNS
cord-291950-9gtsqyfj	262	6	,	,	,
cord-291950-9gtsqyfj	262	7	all	all	PDT
cord-291950-9gtsqyfj	262	8	the	the	DT
cord-291950-9gtsqyfj	262	9	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	262	10	have	have	VBP
cord-291950-9gtsqyfj	262	11	a	a	DT
cord-291950-9gtsqyfj	262	12	Cys	Cys	NNP
cord-291950-9gtsqyfj	262	13	,	,	,
cord-291950-9gtsqyfj	262	14	His	-PRON-	PRP$
cord-291950-9gtsqyfj	262	15	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	262	16	dyad	dyad	NN
cord-291950-9gtsqyfj	262	17	,	,	,
cord-291950-9gtsqyfj	262	18	suggesting	suggest	VBG
cord-291950-9gtsqyfj	262	19	papain	papain	NN
cord-291950-9gtsqyfj	262	20	-	-	HYPH
cord-291950-9gtsqyfj	262	21	like	like	JJ
cord-291950-9gtsqyfj	262	22	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	262	23	folds	fold	NNS
cord-291950-9gtsqyfj	262	24	,	,	,
cord-291950-9gtsqyfj	262	25	and	and	CC
cord-291950-9gtsqyfj	262	26	are	be	VBP
cord-291950-9gtsqyfj	262	27	probably	probably	RB
cord-291950-9gtsqyfj	262	28	derived	derive	VBN
cord-291950-9gtsqyfj	262	29	from	from	IN
cord-291950-9gtsqyfj	262	30	one	one	CD
cord-291950-9gtsqyfj	262	31	or	or	CC
cord-291950-9gtsqyfj	262	32	two	two	CD
cord-291950-9gtsqyfj	262	33	sequence	sequence	NN
cord-291950-9gtsqyfj	262	34	duplications	duplication	NNS
cord-291950-9gtsqyfj	262	35	.	.	.
cord-291950-9gtsqyfj	263	1	Such	such	JJ
cord-291950-9gtsqyfj	263	2	duplications	duplication	NNS
cord-291950-9gtsqyfj	263	3	appear	appear	VBP
cord-291950-9gtsqyfj	263	4	to	to	TO
cord-291950-9gtsqyfj	263	5	have	have	VB
cord-291950-9gtsqyfj	263	6	been	be	VBN
cord-291950-9gtsqyfj	263	7	as	as	RB
cord-291950-9gtsqyfj	263	8	ancient	ancient	JJ
cord-291950-9gtsqyfj	263	9	as	as	IN
cord-291950-9gtsqyfj	263	10	the	the	DT
cord-291950-9gtsqyfj	263	11	speciation	speciation	NN
cord-291950-9gtsqyfj	263	12	events	event	NNS
cord-291950-9gtsqyfj	263	13	that	that	WDT
cord-291950-9gtsqyfj	263	14	gave	give	VBD
cord-291950-9gtsqyfj	263	15	rise	rise	NN
cord-291950-9gtsqyfj	263	16	to	to	IN
cord-291950-9gtsqyfj	263	17	the	the	DT
cord-291950-9gtsqyfj	263	18	different	different	JJ
cord-291950-9gtsqyfj	263	19	viruses	virus	NNS
cord-291950-9gtsqyfj	263	20	,	,	,
cord-291950-9gtsqyfj	263	21	because	because	IN
cord-291950-9gtsqyfj	263	22	there	there	EX
cord-291950-9gtsqyfj	263	23	is	be	VBZ
cord-291950-9gtsqyfj	263	24	no	no	DT
cord-291950-9gtsqyfj	263	25	significant	significant	JJ
cord-291950-9gtsqyfj	263	26	sequence	sequence	NN
cord-291950-9gtsqyfj	263	27	similarity	similarity	NN
cord-291950-9gtsqyfj	263	28	,	,	,
cord-291950-9gtsqyfj	263	29	and	and	CC
cord-291950-9gtsqyfj	263	30	hence	hence	RB
cord-291950-9gtsqyfj	263	31	the	the	DT
cord-291950-9gtsqyfj	263	32	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	263	33	are	be	VBP
cord-291950-9gtsqyfj	263	34	in	in	IN
cord-291950-9gtsqyfj	263	35	different	different	JJ
cord-291950-9gtsqyfj	263	36	families	family	NNS
cord-291950-9gtsqyfj	263	37	.	.	.
cord-291950-9gtsqyfj	264	1	The	the	DT
cord-291950-9gtsqyfj	264	2	crystal	crystal	JJ
cord-291950-9gtsqyfj	264	3	structure	structure	NN
cord-291950-9gtsqyfj	264	4	of	of	IN
cord-291950-9gtsqyfj	264	5	the	the	DT
cord-291950-9gtsqyfj	264	6	L	l	NN
cord-291950-9gtsqyfj	264	7	-	-	HYPH
cord-291950-9gtsqyfj	264	8	peptidase	peptidase	NN
cord-291950-9gtsqyfj	264	9	from	from	IN
cord-291950-9gtsqyfj	264	10	the	the	DT
cord-291950-9gtsqyfj	264	11	footand	footand	NN
cord-291950-9gtsqyfj	264	12	-	-	HYPH
cord-291950-9gtsqyfj	264	13	mouth	mouth	NN
cord-291950-9gtsqyfj	264	14	disease	disease	NN
cord-291950-9gtsqyfj	264	15	virus	virus	NN
cord-291950-9gtsqyfj	264	16	(	(	-LRB-
cord-291950-9gtsqyfj	264	17	in	in	IN
cord-291950-9gtsqyfj	264	18	family	family	NN
cord-291950-9gtsqyfj	264	19	C28	c28	NN
cord-291950-9gtsqyfj	264	20	)	)	-RRB-
cord-291950-9gtsqyfj	264	21	shows	show	VBZ
cord-291950-9gtsqyfj	264	22	a	a	DT
cord-291950-9gtsqyfj	264	23	clear	clear	JJ
cord-291950-9gtsqyfj	264	24	relationship	relationship	NN
cord-291950-9gtsqyfj	264	25	to	to	IN
cord-291950-9gtsqyfj	264	26	papain	papain	NN
cord-291950-9gtsqyfj	264	27	.	.	.
cord-291950-9gtsqyfj	265	1	Although	although	IN
cord-291950-9gtsqyfj	265	2	aphthoviruses	aphthoviruse	NNS
cord-291950-9gtsqyfj	265	3	such	such	JJ
cord-291950-9gtsqyfj	265	4	as	as	IN
cord-291950-9gtsqyfj	265	5	the	the	DT
cord-291950-9gtsqyfj	265	6	foot	foot	NN
cord-291950-9gtsqyfj	265	7	-	-	HYPH
cord-291950-9gtsqyfj	265	8	and	and	CC
cord-291950-9gtsqyfj	265	9	-	-	HYPH
cord-291950-9gtsqyfj	265	10	mouth	mouth	NN
cord-291950-9gtsqyfj	265	11	disease	disease	NN
cord-291950-9gtsqyfj	265	12	virus	virus	NN
cord-291950-9gtsqyfj	265	13	possess	possess	VBP
cord-291950-9gtsqyfj	265	14	picornain	picornain	NNP
cord-291950-9gtsqyfj	265	15	3C	3C	NNP
cord-291950-9gtsqyfj	265	16	(	(	-LRB-
cord-291950-9gtsqyfj	265	17	Chapter	chapter	NN
cord-291950-9gtsqyfj	265	18	537	537	CD
cord-291950-9gtsqyfj	265	19	)	)	-RRB-
cord-291950-9gtsqyfj	265	20	as	as	IN
cord-291950-9gtsqyfj	265	21	a	a	DT
cord-291950-9gtsqyfj	265	22	general	general	JJ
cord-291950-9gtsqyfj	265	23	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	265	24	-	-	HYPH
cord-291950-9gtsqyfj	265	25	processing	processing	NN
cord-291950-9gtsqyfj	265	26	enzyme	enzyme	NN
cord-291950-9gtsqyfj	265	27	,	,	,
cord-291950-9gtsqyfj	265	28	they	-PRON-	PRP
cord-291950-9gtsqyfj	265	29	lack	lack	VBP
cord-291950-9gtsqyfj	265	30	a	a	DT
cord-291950-9gtsqyfj	265	31	picornain	picornain	NN
cord-291950-9gtsqyfj	265	32	2A	2a	NN
cord-291950-9gtsqyfj	265	33	,	,	,
cord-291950-9gtsqyfj	265	34	and	and	CC
cord-291950-9gtsqyfj	265	35	the	the	DT
cord-291950-9gtsqyfj	265	36	functions	function	NNS
cord-291950-9gtsqyfj	265	37	of	of	IN
cord-291950-9gtsqyfj	265	38	that	that	DT
cord-291950-9gtsqyfj	265	39	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	265	40	are	be	VBP
cord-291950-9gtsqyfj	265	41	performed	perform	VBN
cord-291950-9gtsqyfj	265	42	by	by	IN
cord-291950-9gtsqyfj	265	43	the	the	DT
cord-291950-9gtsqyfj	265	44	L	l	NN
cord-291950-9gtsqyfj	265	45	-	-	HYPH
cord-291950-9gtsqyfj	265	46	peptidase	peptidase	NN
cord-291950-9gtsqyfj	265	47	or	or	CC
cord-291950-9gtsqyfj	265	48	an	an	DT
cord-291950-9gtsqyfj	265	49	autolytic	autolytic	JJ
cord-291950-9gtsqyfj	265	50	activity	activity	NN
cord-291950-9gtsqyfj	265	51	(	(	-LRB-
cord-291950-9gtsqyfj	265	52	see	see	VB
cord-291950-9gtsqyfj	265	53	Chapter	chapter	NN
cord-291950-9gtsqyfj	265	54	491	491	CD
cord-291950-9gtsqyfj	265	55	)	)	-RRB-
cord-291950-9gtsqyfj	265	56	.	.	.
cord-291950-9gtsqyfj	266	1	The	the	DT
cord-291950-9gtsqyfj	266	2	L	l	NN
cord-291950-9gtsqyfj	266	3	-	-	HYPH
cord-291950-9gtsqyfj	266	4	peptidase	peptidase	NN
cord-291950-9gtsqyfj	266	5	is	be	VBZ
cord-291950-9gtsqyfj	266	6	sited	site	VBN
cord-291950-9gtsqyfj	266	7	at	at	IN
cord-291950-9gtsqyfj	266	8	the	the	DT
cord-291950-9gtsqyfj	266	9	N	n	CD
cord-291950-9gtsqyfj	266	10	-	-	HYPH
cord-291950-9gtsqyfj	266	11	terminus	terminus	NN
cord-291950-9gtsqyfj	266	12	of	of	IN
cord-291950-9gtsqyfj	266	13	the	the	DT
cord-291950-9gtsqyfj	266	14	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	266	15	,	,	,
cord-291950-9gtsqyfj	266	16	from	from	IN
cord-291950-9gtsqyfj	266	17	which	which	WDT
cord-291950-9gtsqyfj	266	18	it	-PRON-	PRP
cord-291950-9gtsqyfj	266	19	releases	release	VBZ
cord-291950-9gtsqyfj	266	20	itself	-PRON-	PRP
cord-291950-9gtsqyfj	266	21	.	.	.
cord-291950-9gtsqyfj	267	1	The	the	DT
cord-291950-9gtsqyfj	267	2	L	l	NN
cord-291950-9gtsqyfj	267	3	-	-	HYPH
cord-291950-9gtsqyfj	267	4	peptidase	peptidase	NN
cord-291950-9gtsqyfj	267	5	also	also	RB
cord-291950-9gtsqyfj	267	6	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	267	7	the	the	DT
cord-291950-9gtsqyfj	267	8	eukaryotic	eukaryotic	JJ
cord-291950-9gtsqyfj	267	9	initiation	initiation	NN
cord-291950-9gtsqyfj	267	10	factor	factor	NN
cord-291950-9gtsqyfj	267	11	eIF-4	eIF-4	NNP
cord-291950-9gtsqyfj	267	12	G	G	NNP
cord-291950-9gtsqyfj	267	13	(	(	-LRB-
cord-291950-9gtsqyfj	267	14	formerly	formerly	RB
cord-291950-9gtsqyfj	267	15	known	know	VBN
cord-291950-9gtsqyfj	267	16	as	as	IN
cord-291950-9gtsqyfj	267	17	p220	p220	NNP
cord-291950-9gtsqyfj	267	18	or	or	CC
cord-291950-9gtsqyfj	267	19	eIF-4γ	eIF-4γ	NNP
cord-291950-9gtsqyfj	267	20	)	)	-RRB-
cord-291950-9gtsqyfj	267	21	,	,	,
cord-291950-9gtsqyfj	267	22	thus	thus	RB
cord-291950-9gtsqyfj	267	23	preventing	prevent	VBG
cord-291950-9gtsqyfj	267	24	cap	cap	NN
cord-291950-9gtsqyfj	267	25	-	-	HYPH
cord-291950-9gtsqyfj	267	26	dependent	dependent	JJ
cord-291950-9gtsqyfj	267	27	synthesis	synthesis	NN
cord-291950-9gtsqyfj	267	28	of	of	IN
cord-291950-9gtsqyfj	267	29	hostcell	hostcell	NNP
cord-291950-9gtsqyfj	267	30	proteins	protein	NNS
cord-291950-9gtsqyfj	267	31	.	.	.
cord-291950-9gtsqyfj	268	1	Family	Family	NNP
cord-291950-9gtsqyfj	268	2	C16	C16	NNP
cord-291950-9gtsqyfj	268	3	contains	contain	VBZ
cord-291950-9gtsqyfj	268	4	the	the	DT
cord-291950-9gtsqyfj	268	5	mouse	mouse	NN
cord-291950-9gtsqyfj	268	6	hepatitis	hepatitis	NNP
cord-291950-9gtsqyfj	268	7	virus	virus	NN
cord-291950-9gtsqyfj	268	8	p28	p28	CD
cord-291950-9gtsqyfj	268	9	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	268	10	,	,	,
cord-291950-9gtsqyfj	268	11	which	which	WDT
cord-291950-9gtsqyfj	268	12	releases	release	VBZ
cord-291950-9gtsqyfj	268	13	itself	-PRON-	PRP
cord-291950-9gtsqyfj	268	14	from	from	IN
cord-291950-9gtsqyfj	268	15	the	the	DT
cord-291950-9gtsqyfj	268	16	N	n	CD
cord-291950-9gtsqyfj	268	17	-	-	HYPH
cord-291950-9gtsqyfj	268	18	terminus	terminus	NN
cord-291950-9gtsqyfj	268	19	of	of	IN
cord-291950-9gtsqyfj	268	20	the	the	DT
cord-291950-9gtsqyfj	268	21	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	268	22	encoded	encode	VBN
cord-291950-9gtsqyfj	268	23	by	by	IN
cord-291950-9gtsqyfj	268	24	gene	gene	NN
cord-291950-9gtsqyfj	268	25	A.	a.	NN
cord-291950-9gtsqyfj	269	1	The	the	DT
cord-291950-9gtsqyfj	269	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	269	3	dyad	dyad	NN
cord-291950-9gtsqyfj	269	4	has	have	VBZ
cord-291950-9gtsqyfj	269	5	been	be	VBN
cord-291950-9gtsqyfj	269	6	identified	identify	VBN
cord-291950-9gtsqyfj	269	7	by	by	IN
cord-291950-9gtsqyfj	269	8	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	269	9	[	[	-LRB-
cord-291950-9gtsqyfj	269	10	40	40	CD
cord-291950-9gtsqyfj	269	11	]	]	-RRB-
cord-291950-9gtsqyfj	269	12	.	.	.
cord-291950-9gtsqyfj	270	1	The	the	DT
cord-291950-9gtsqyfj	270	2	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	270	3	encoded	encode	VBN
cord-291950-9gtsqyfj	270	4	by	by	IN
cord-291950-9gtsqyfj	270	5	gene	gene	NN
cord-291950-9gtsqyfj	270	6	A	A	NNP
cord-291950-9gtsqyfj	270	7	includes	include	VBZ
cord-291950-9gtsqyfj	270	8	a	a	DT
cord-291950-9gtsqyfj	270	9	picornain	picornain	NN
cord-291950-9gtsqyfj	270	10	-	-	HYPH
cord-291950-9gtsqyfj	270	11	like	like	JJ
cord-291950-9gtsqyfj	270	12	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	270	13	and	and	CC
cord-291950-9gtsqyfj	270	14	a	a	DT
cord-291950-9gtsqyfj	270	15	putative	putative	JJ
cord-291950-9gtsqyfj	270	16	second	second	JJ
cord-291950-9gtsqyfj	270	17	papain	papain	NN
cord-291950-9gtsqyfj	270	18	-	-	HYPH
cord-291950-9gtsqyfj	270	19	like	like	JJ
cord-291950-9gtsqyfj	270	20	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	270	21	,	,	,
cord-291950-9gtsqyfj	270	22	formerly	formerly	RB
cord-291950-9gtsqyfj	270	23	assigned	assign	VBN
cord-291950-9gtsqyfj	270	24	to	to	IN
cord-291950-9gtsqyfj	270	25	a	a	DT
cord-291950-9gtsqyfj	270	26	separate	separate	JJ
cord-291950-9gtsqyfj	270	27	family	family	NN
cord-291950-9gtsqyfj	270	28	,	,	,
cord-291950-9gtsqyfj	270	29	C29	C29	NNP
cord-291950-9gtsqyfj	270	30	,	,	,
cord-291950-9gtsqyfj	270	31	but	but	CC
cord-291950-9gtsqyfj	270	32	now	now	RB
cord-291950-9gtsqyfj	270	33	considered	consider	VBN
cord-291950-9gtsqyfj	270	34	to	to	TO
cord-291950-9gtsqyfj	270	35	be	be	VB
cord-291950-9gtsqyfj	270	36	a	a	DT
cord-291950-9gtsqyfj	270	37	member	member	NN
cord-291950-9gtsqyfj	270	38	of	of	IN
cord-291950-9gtsqyfj	270	39	family	family	NN
cord-291950-9gtsqyfj	270	40	C16	C16	NNP
cord-291950-9gtsqyfj	270	41	.	.	.
cord-291950-9gtsqyfj	271	1	The	the	DT
cord-291950-9gtsqyfj	271	2	compound	compound	NN
cord-291950-9gtsqyfj	271	3	E-64c	E-64c	NNP
cord-291950-9gtsqyfj	271	4	inhibits	inhibit	VBZ
cord-291950-9gtsqyfj	271	5	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	271	6	processing	processing	NN
cord-291950-9gtsqyfj	271	7	in	in	IN
cord-291950-9gtsqyfj	271	8	the	the	DT
cord-291950-9gtsqyfj	271	9	mouse	mouse	NN
cord-291950-9gtsqyfj	271	10	hepatitis	hepatitis	NN
cord-291950-9gtsqyfj	271	11	virus	virus	NN
cord-291950-9gtsqyfj	271	12	[	[	-LRB-
cord-291950-9gtsqyfj	271	13	41	41	CD
cord-291950-9gtsqyfj	271	14	]	]	-RRB-
cord-291950-9gtsqyfj	271	15	,	,	,
cord-291950-9gtsqyfj	271	16	presumably	presumably	RB
cord-291950-9gtsqyfj	271	17	by	by	IN
cord-291950-9gtsqyfj	271	18	inhibiting	inhibit	VBG
cord-291950-9gtsqyfj	271	19	the	the	DT
cord-291950-9gtsqyfj	271	20	action	action	NN
cord-291950-9gtsqyfj	271	21	of	of	IN
cord-291950-9gtsqyfj	271	22	one	one	CD
cord-291950-9gtsqyfj	271	23	or	or	CC
cord-291950-9gtsqyfj	271	24	both	both	DT
cord-291950-9gtsqyfj	271	25	of	of	IN
cord-291950-9gtsqyfj	271	26	the	the	DT
cord-291950-9gtsqyfj	271	27	two	two	CD
cord-291950-9gtsqyfj	271	28	papain	papain	NN
cord-291950-9gtsqyfj	271	29	-	-	HYPH
cord-291950-9gtsqyfj	271	30	like	like	JJ
cord-291950-9gtsqyfj	271	31	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	271	32	.	.	.
cord-291950-9gtsqyfj	272	1	The	the	DT
cord-291950-9gtsqyfj	272	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	272	3	structure	structure	NN
cord-291950-9gtsqyfj	272	4	of	of	IN
cord-291950-9gtsqyfj	272	5	the	the	DT
cord-291950-9gtsqyfj	272	6	papain	papain	NN
cord-291950-9gtsqyfj	272	7	-	-	HYPH
cord-291950-9gtsqyfj	272	8	like	like	JJ
cord-291950-9gtsqyfj	272	9	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	272	10	from	from	IN
cord-291950-9gtsqyfj	272	11	SARS	SARS	NNP
cord-291950-9gtsqyfj	272	12	virus	virus	NN
cord-291950-9gtsqyfj	272	13	has	have	VBZ
cord-291950-9gtsqyfj	272	14	been	be	VBN
cord-291950-9gtsqyfj	272	15	solved	solve	VBN
cord-291950-9gtsqyfj	272	16	(	(	-LRB-
cord-291950-9gtsqyfj	272	17	see	see	VB
cord-291950-9gtsqyfj	272	18	Figure	Figure	NNP
cord-291950-9gtsqyfj	272	19	404	404	CD
cord-291950-9gtsqyfj	272	20	.	.	.
cord-291950-9gtsqyfj	272	21	19	19	CD
cord-291950-9gtsqyfj	272	22	)	)	-RRB-
cord-291950-9gtsqyfj	272	23	.	.	.
cord-291950-9gtsqyfj	273	1	Families	family	NNS
cord-291950-9gtsqyfj	273	2	C31	C31	NNP
cord-291950-9gtsqyfj	273	3	,	,	,
cord-291950-9gtsqyfj	273	4	C32	C32	NNP
cord-291950-9gtsqyfj	273	5	and	and	CC
cord-291950-9gtsqyfj	273	6	C33	C33	NNP
cord-291950-9gtsqyfj	273	7	include	include	VBP
cord-291950-9gtsqyfj	273	8	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	273	9	-	-	HYPH
cord-291950-9gtsqyfj	273	10	processing	process	VBG
cord-291950-9gtsqyfj	273	11	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	273	12	from	from	IN
cord-291950-9gtsqyfj	273	13	arteriviruses	arteriviruse	NNS
cord-291950-9gtsqyfj	273	14	.	.	.
cord-291950-9gtsqyfj	274	1	In	in	IN
cord-291950-9gtsqyfj	274	2	the	the	DT
cord-291950-9gtsqyfj	274	3	Lelystad	Lelystad	NNP
cord-291950-9gtsqyfj	274	4	(	(	-LRB-
cord-291950-9gtsqyfj	274	5	porcine	porcine	JJ
cord-291950-9gtsqyfj	274	6	reproductive	reproductive	JJ
cord-291950-9gtsqyfj	274	7	and	and	CC
cord-291950-9gtsqyfj	274	8	respiratory	respiratory	JJ
cord-291950-9gtsqyfj	274	9	syndrome	syndrome	NN
cord-291950-9gtsqyfj	274	10	)	)	-RRB-
cord-291950-9gtsqyfj	274	11	virus	virus	NN
cord-291950-9gtsqyfj	274	12	,	,	,
cord-291950-9gtsqyfj	274	13	the	the	DT
cord-291950-9gtsqyfj	274	14	three	three	CD
cord-291950-9gtsqyfj	274	15	papain	papain	NN
cord-291950-9gtsqyfj	274	16	-	-	HYPH
cord-291950-9gtsqyfj	274	17	like	like	JJ
cord-291950-9gtsqyfj	274	18	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	274	19	are	be	VBP
cord-291950-9gtsqyfj	274	20	consecutive	consecutive	JJ
cord-291950-9gtsqyfj	274	21	in	in	IN
cord-291950-9gtsqyfj	274	22	the	the	DT
cord-291950-9gtsqyfj	274	23	pol	pol	NN
cord-291950-9gtsqyfj	274	24	polyprotein	polyprotein	NNP
cord-291950-9gtsqyfj	274	25	,	,	,
cord-291950-9gtsqyfj	274	26	with	with	IN
cord-291950-9gtsqyfj	274	27	PCPα	PCPα	NNS
cord-291950-9gtsqyfj	274	28	at	at	IN
cord-291950-9gtsqyfj	274	29	the	the	DT
cord-291950-9gtsqyfj	274	30	N	n	CD
cord-291950-9gtsqyfj	274	31	-	-	HYPH
cord-291950-9gtsqyfj	274	32	terminus	terminus	NN
cord-291950-9gtsqyfj	274	33	,	,	,
cord-291950-9gtsqyfj	274	34	followed	follow	VBN
cord-291950-9gtsqyfj	274	35	by	by	IN
cord-291950-9gtsqyfj	274	36	PCPβ	PCPβ	NNS
cord-291950-9gtsqyfj	274	37	and	and	CC
cord-291950-9gtsqyfj	274	38	then	then	RB
cord-291950-9gtsqyfj	274	39	Nsp2	Nsp2	NNP
cord-291950-9gtsqyfj	274	40	,	,	,
cord-291950-9gtsqyfj	274	41	which	which	WDT
cord-291950-9gtsqyfj	274	42	are	be	VBP
cord-291950-9gtsqyfj	274	43	so	so	RB
cord-291950-9gtsqyfj	274	44	different	different	JJ
cord-291950-9gtsqyfj	274	45	in	in	IN
cord-291950-9gtsqyfj	274	46	sequence	sequence	NN
cord-291950-9gtsqyfj	274	47	that	that	IN
cord-291950-9gtsqyfj	274	48	they	-PRON-	PRP
cord-291950-9gtsqyfj	274	49	are	be	VBP
cord-291950-9gtsqyfj	274	50	assigned	assign	VBN
cord-291950-9gtsqyfj	274	51	to	to	IN
cord-291950-9gtsqyfj	274	52	the	the	DT
cord-291950-9gtsqyfj	274	53	separate	separate	JJ
cord-291950-9gtsqyfj	274	54	families	family	NNS
cord-291950-9gtsqyfj	274	55	C31	C31	NNP
cord-291950-9gtsqyfj	274	56	,	,	,
cord-291950-9gtsqyfj	274	57	C32	C32	NNP
cord-291950-9gtsqyfj	274	58	and	and	CC
cord-291950-9gtsqyfj	274	59	C33	C33	NNP
cord-291950-9gtsqyfj	274	60	,	,	,
cord-291950-9gtsqyfj	274	61	respectively	respectively	RB
cord-291950-9gtsqyfj	274	62	.	.	.
cord-291950-9gtsqyfj	275	1	PCPα	PCPα	NNP
cord-291950-9gtsqyfj	275	2	and	and	CC
cord-291950-9gtsqyfj	275	3	PCPβ	PCPβ	NNS
cord-291950-9gtsqyfj	275	4	together	together	RB
cord-291950-9gtsqyfj	275	5	constitute	constitute	VBP
cord-291950-9gtsqyfj	275	6	the	the	DT
cord-291950-9gtsqyfj	275	7	Nsp1	Nsp1	NNP
cord-291950-9gtsqyfj	275	8	protein	protein	NN
cord-291950-9gtsqyfj	275	9	.	.	.
cord-291950-9gtsqyfj	276	1	The	the	DT
cord-291950-9gtsqyfj	276	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	276	3	dyads	dyad	NNS
cord-291950-9gtsqyfj	276	4	have	have	VBP
cord-291950-9gtsqyfj	276	5	been	be	VBN
cord-291950-9gtsqyfj	276	6	determined	determine	VBN
cord-291950-9gtsqyfj	276	7	by	by	IN
cord-291950-9gtsqyfj	276	8	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	276	9	for	for	IN
cord-291950-9gtsqyfj	276	10	all	all	DT
cord-291950-9gtsqyfj	276	11	three	three	CD
cord-291950-9gtsqyfj	276	12	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	276	13	[	[	-LRB-
cord-291950-9gtsqyfj	276	14	42	42	CD
cord-291950-9gtsqyfj	276	15	,	,	,
cord-291950-9gtsqyfj	276	16	43	43	CD
cord-291950-9gtsqyfj	276	17	]	]	-RRB-
cord-291950-9gtsqyfj	276	18	.	.	.
cord-291950-9gtsqyfj	277	1	Besides	besides	IN
cord-291950-9gtsqyfj	277	2	the	the	DT
cord-291950-9gtsqyfj	277	3	three	three	CD
cord-291950-9gtsqyfj	277	4	papain	papain	NN
cord-291950-9gtsqyfj	277	5	-	-	HYPH
cord-291950-9gtsqyfj	277	6	like	like	JJ
cord-291950-9gtsqyfj	277	7	cysteine	cysteine	JJ
cord-291950-9gtsqyfj	277	8	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	277	9	,	,	,
cord-291950-9gtsqyfj	277	10	the	the	DT
cord-291950-9gtsqyfj	277	11	arteriviruses	arteriviruse	NNS
cord-291950-9gtsqyfj	277	12	possess	possess	VBP
cord-291950-9gtsqyfj	277	13	a	a	DT
cord-291950-9gtsqyfj	277	14	fourth	fourth	JJ
cord-291950-9gtsqyfj	277	15	,	,	,
cord-291950-9gtsqyfj	277	16	serinetype	serinetype	NN
cord-291950-9gtsqyfj	277	17	,	,	,
cord-291950-9gtsqyfj	277	18	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	277	19	(	(	-LRB-
cord-291950-9gtsqyfj	277	20	see	see	VB
cord-291950-9gtsqyfj	277	21	Chapter	chapter	NN
cord-291950-9gtsqyfj	277	22	691	691	CD
cord-291950-9gtsqyfj	277	23	)	)	-RRB-
cord-291950-9gtsqyfj	277	24	in	in	IN
cord-291950-9gtsqyfj	277	25	the	the	DT
cord-291950-9gtsqyfj	277	26	pol	pol	NNP
cord-291950-9gtsqyfj	277	27	polyprotein	polyprotein	NNP
cord-291950-9gtsqyfj	277	28	.	.	.
cord-291950-9gtsqyfj	278	1	Not	not	RB
cord-291950-9gtsqyfj	278	2	all	all	DT
cord-291950-9gtsqyfj	278	3	arteriviruses	arteriviruse	NNS
cord-291950-9gtsqyfj	278	4	require	require	VBP
cord-291950-9gtsqyfj	278	5	all	all	DT
cord-291950-9gtsqyfj	278	6	four	four	CD
cord-291950-9gtsqyfj	278	7	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	278	8	,	,	,
cord-291950-9gtsqyfj	278	9	because	because	IN
cord-291950-9gtsqyfj	278	10	in	in	IN
cord-291950-9gtsqyfj	278	11	the	the	DT
cord-291950-9gtsqyfj	278	12	equine	equine	JJ
cord-291950-9gtsqyfj	278	13	arteritis	arteritis	NN
cord-291950-9gtsqyfj	278	14	virus	virus	NN
cord-291950-9gtsqyfj	278	15	,	,	,
cord-291950-9gtsqyfj	278	16	PCPα	PCPα	NNP
cord-291950-9gtsqyfj	278	17	is	be	VBZ
cord-291950-9gtsqyfj	278	18	inactive	inactive	JJ
cord-291950-9gtsqyfj	278	19	,	,	,
cord-291950-9gtsqyfj	278	20	the	the	DT
cord-291950-9gtsqyfj	278	21	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	278	22	Cys	Cys	NNP
cord-291950-9gtsqyfj	278	23	being	be	VBG
cord-291950-9gtsqyfj	278	24	replaced	replace	VBN
cord-291950-9gtsqyfj	278	25	by	by	IN
cord-291950-9gtsqyfj	278	26	Lys	Lys	NNP
cord-291950-9gtsqyfj	278	27	.	.	.
cord-291950-9gtsqyfj	279	1	The	the	DT
cord-291950-9gtsqyfj	279	2	PCPα	PCPα	NNS
cord-291950-9gtsqyfj	279	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	279	4	releases	release	VBZ
cord-291950-9gtsqyfj	279	5	itself	-PRON-	PRP
cord-291950-9gtsqyfj	279	6	from	from	IN
cord-291950-9gtsqyfj	279	7	the	the	DT
cord-291950-9gtsqyfj	279	8	N	n	CD
cord-291950-9gtsqyfj	279	9	-	-	HYPH
cord-291950-9gtsqyfj	279	10	terminus	terminus	NN
cord-291950-9gtsqyfj	279	11	of	of	IN
cord-291950-9gtsqyfj	279	12	the	the	DT
cord-291950-9gtsqyfj	279	13	Nsp1	Nsp1	NNP
cord-291950-9gtsqyfj	279	14	protein	protein	NN
cord-291950-9gtsqyfj	279	15	[	[	-LRB-
cord-291950-9gtsqyfj	279	16	42	42	CD
cord-291950-9gtsqyfj	279	17	]	]	-RRB-
cord-291950-9gtsqyfj	279	18	.	.	.
cord-291950-9gtsqyfj	280	1	The	the	DT
cord-291950-9gtsqyfj	280	2	PCPα	PCPα	NNS
cord-291950-9gtsqyfj	280	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	280	4	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	280	5	between	between	IN
cord-291950-9gtsqyfj	280	6	the	the	DT
cord-291950-9gtsqyfj	280	7	Nsp1	Nsp1	NNP
cord-291950-9gtsqyfj	280	8	and	and	CC
cord-291950-9gtsqyfj	280	9	Nsp2	Nsp2	NNP
cord-291950-9gtsqyfj	280	10	proteins	protein	NNS
cord-291950-9gtsqyfj	280	11	in	in	IN
cord-291950-9gtsqyfj	280	12	the	the	DT
cord-291950-9gtsqyfj	280	13	pol	pol	NN
cord-291950-9gtsqyfj	280	14	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	280	15	[	[	-LRB-
cord-291950-9gtsqyfj	280	16	42	42	CD
cord-291950-9gtsqyfj	280	17	]	]	-RRB-
cord-291950-9gtsqyfj	280	18	.	.	.
cord-291950-9gtsqyfj	281	1	The	the	DT
cord-291950-9gtsqyfj	281	2	Nsp2	Nsp2	NNP
cord-291950-9gtsqyfj	281	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	281	4	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	281	5	between	between	IN
cord-291950-9gtsqyfj	281	6	the	the	DT
cord-291950-9gtsqyfj	281	7	Nsp2	Nsp2	NNP
cord-291950-9gtsqyfj	281	8	and	and	CC
cord-291950-9gtsqyfj	281	9	Nsp3	Nsp3	NNP
cord-291950-9gtsqyfj	281	10	proteins	protein	NNS
cord-291950-9gtsqyfj	281	11	,	,	,
cord-291950-9gtsqyfj	281	12	and	and	CC
cord-291950-9gtsqyfj	281	13	,	,	,
cord-291950-9gtsqyfj	282	1	unusually	unusually	RB
cord-291950-9gtsqyfj	282	2	,	,	,
cord-291950-9gtsqyfj	282	3	the	the	DT
cord-291950-9gtsqyfj	282	4	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	282	5	Cys	Cys	NNP
cord-291950-9gtsqyfj	282	6	is	be	VBZ
cord-291950-9gtsqyfj	282	7	followed	follow	VBN
cord-291950-9gtsqyfj	282	8	by	by	IN
cord-291950-9gtsqyfj	282	9	Gly	Gly	NNP
cord-291950-9gtsqyfj	282	10	.	.	.
cord-291950-9gtsqyfj	283	1	Cys	Cys	NNP
cord-291950-9gtsqyfj	283	2	-	-	HYPH
cord-291950-9gtsqyfj	283	3	Gly	Gly	NNP
cord-291950-9gtsqyfj	283	4	is	be	VBZ
cord-291950-9gtsqyfj	283	5	generally	generally	RB
cord-291950-9gtsqyfj	283	6	regarded	regard	VBN
cord-291950-9gtsqyfj	283	7	as	as	RB
cord-291950-9gtsqyfj	283	8	diagnostic	diagnostic	JJ
cord-291950-9gtsqyfj	283	9	for	for	IN
cord-291950-9gtsqyfj	283	10	the	the	DT
cord-291950-9gtsqyfj	283	11	subclan	subclan	NNP
cord-291950-9gtsqyfj	283	12	PA(C	pa(c	CD
cord-291950-9gtsqyfj	283	13	)	)	-RRB-
cord-291950-9gtsqyfj	283	14	viral	viral	JJ
cord-291950-9gtsqyfj	283	15	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	283	16	,	,	,
cord-291950-9gtsqyfj	283	17	but	but	CC
cord-291950-9gtsqyfj	283	18	it	-PRON-	PRP
cord-291950-9gtsqyfj	283	19	has	have	VBZ
cord-291950-9gtsqyfj	283	20	also	also	RB
cord-291950-9gtsqyfj	283	21	been	be	VBN
cord-291950-9gtsqyfj	283	22	seen	see	VBN
cord-291950-9gtsqyfj	283	23	in	in	IN
cord-291950-9gtsqyfj	283	24	some	some	DT
cord-291950-9gtsqyfj	283	25	calpain	calpain	NN
cord-291950-9gtsqyfj	283	26	homologs	homolog	NNS
cord-291950-9gtsqyfj	283	27	[	[	-LRB-
cord-291950-9gtsqyfj	283	28	43	43	CD
cord-291950-9gtsqyfj	283	29	]	]	-RRB-
cord-291950-9gtsqyfj	283	30	and	and	CC
cord-291950-9gtsqyfj	283	31	in	in	IN
cord-291950-9gtsqyfj	283	32	family	family	NN
cord-291950-9gtsqyfj	283	33	C12	C12	NNP
cord-291950-9gtsqyfj	283	34	.	.	.
cord-291950-9gtsqyfj	284	1	In	in	IN
cord-291950-9gtsqyfj	284	2	the	the	DT
cord-291950-9gtsqyfj	284	3	archaean	archaean	JJ
cord-291950-9gtsqyfj	284	4	Methanothermobacter	Methanothermobacter	NNP
cord-291950-9gtsqyfj	284	5	,	,	,
cord-291950-9gtsqyfj	284	6	the	the	DT
cord-291950-9gtsqyfj	284	7	cell	cell	NN
cord-291950-9gtsqyfj	284	8	wall	wall	NN
cord-291950-9gtsqyfj	284	9	is	be	VBZ
cord-291950-9gtsqyfj	284	10	analogous	analogous	JJ
cord-291950-9gtsqyfj	284	11	to	to	IN
cord-291950-9gtsqyfj	284	12	that	that	DT
cord-291950-9gtsqyfj	284	13	of	of	IN
cord-291950-9gtsqyfj	284	14	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	284	15	,	,	,
cord-291950-9gtsqyfj	284	16	but	but	CC
cord-291950-9gtsqyfj	284	17	the	the	DT
cord-291950-9gtsqyfj	284	18	crosslinking	crosslinking	NN
cord-291950-9gtsqyfj	284	19	peptide	peptide	NN
cord-291950-9gtsqyfj	284	20	contains	contain	VBZ
cord-291950-9gtsqyfj	284	21	amino	amino	NN
cord-291950-9gtsqyfj	284	22	acids	acid	NNS
cord-291950-9gtsqyfj	284	23	only	only	RB
cord-291950-9gtsqyfj	284	24	in	in	IN
cord-291950-9gtsqyfj	284	25	the	the	DT
cord-291950-9gtsqyfj	284	26	normal	normal	JJ
cord-291950-9gtsqyfj	284	27	,	,	,
cord-291950-9gtsqyfj	284	28	laevo	laevo	NNP
cord-291950-9gtsqyfj	284	29	,	,	,
cord-291950-9gtsqyfj	284	30	orientation	orientation	NN
cord-291950-9gtsqyfj	284	31	.	.	.
cord-291950-9gtsqyfj	285	1	The	the	DT
cord-291950-9gtsqyfj	285	2	crosslink	crosslink	NN
cord-291950-9gtsqyfj	285	3	is	be	VBZ
cord-291950-9gtsqyfj	285	4	made	make	VBN
cord-291950-9gtsqyfj	285	5	between	between	IN
cord-291950-9gtsqyfj	285	6	the	the	DT
cord-291950-9gtsqyfj	285	7	ε	ε	NNP
cord-291950-9gtsqyfj	285	8	-	-	HYPH
cord-291950-9gtsqyfj	285	9	amino	amino	NNP
cord-291950-9gtsqyfj	285	10	group	group	NN
cord-291950-9gtsqyfj	285	11	of	of	IN
cord-291950-9gtsqyfj	285	12	L	L	NNP
cord-291950-9gtsqyfj	285	13	-	-	HYPH
cord-291950-9gtsqyfj	285	14	Lys	Lys	NNP
cord-291950-9gtsqyfj	285	15	and	and	CC
cord-291950-9gtsqyfj	285	16	the	the	DT
cord-291950-9gtsqyfj	285	17	α	α	NN
cord-291950-9gtsqyfj	285	18	-	-	HYPH
cord-291950-9gtsqyfj	285	19	carboxyl	carboxyl	CD
cord-291950-9gtsqyfj	285	20	group	group	NN
cord-291950-9gtsqyfj	285	21	of	of	IN
cord-291950-9gtsqyfj	285	22	L	L	NNP
cord-291950-9gtsqyfj	285	23	-	-	HYPH
cord-291950-9gtsqyfj	285	24	Ala	Ala	NNP
cord-291950-9gtsqyfj	285	25	.	.	.
cord-291950-9gtsqyfj	286	1	It	-PRON-	PRP
cord-291950-9gtsqyfj	286	2	is	be	VBZ
cord-291950-9gtsqyfj	286	3	this	this	DT
cord-291950-9gtsqyfj	286	4	bond	bond	NN
cord-291950-9gtsqyfj	286	5	that	that	WDT
cord-291950-9gtsqyfj	286	6	is	be	VBZ
cord-291950-9gtsqyfj	286	7	broken	break	VBN
cord-291950-9gtsqyfj	286	8	by	by	IN
cord-291950-9gtsqyfj	286	9	the	the	DT
cord-291950-9gtsqyfj	286	10	pseudomurein	pseudomurein	NNP
cord-291950-9gtsqyfj	286	11	endoisopeptidase	endoisopeptidase	NNP
cord-291950-9gtsqyfj	286	12	(	(	-LRB-
cord-291950-9gtsqyfj	286	13	family	family	NN
cord-291950-9gtsqyfj	286	14	C71	C71	NNP
cord-291950-9gtsqyfj	286	15	)	)	-RRB-
cord-291950-9gtsqyfj	286	16	from	from	IN
cord-291950-9gtsqyfj	286	17	Methanobacterium	Methanobacterium	NNP
cord-291950-9gtsqyfj	286	18	phage	phage	NN
cord-291950-9gtsqyfj	286	19	psiM2	psim2	CD
cord-291950-9gtsqyfj	286	20	.	.	.
cord-291950-9gtsqyfj	287	1	The	the	DT
cord-291950-9gtsqyfj	287	2	enzyme	enzyme	NN
cord-291950-9gtsqyfj	287	3	can	can	MD
cord-291950-9gtsqyfj	287	4	be	be	VB
cord-291950-9gtsqyfj	287	5	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	287	6	by	by	IN
cord-291950-9gtsqyfj	287	7	EDTA	EDTA	NNP
cord-291950-9gtsqyfj	287	8	,	,	,
cord-291950-9gtsqyfj	287	9	suggesting	suggest	VBG
cord-291950-9gtsqyfj	287	10	that	that	IN
cord-291950-9gtsqyfj	287	11	metal	metal	NN
cord-291950-9gtsqyfj	287	12	ions	ion	NNS
cord-291950-9gtsqyfj	287	13	are	be	VBP
cord-291950-9gtsqyfj	287	14	important	important	JJ
cord-291950-9gtsqyfj	287	15	for	for	IN
cord-291950-9gtsqyfj	287	16	activity	activity	NN
cord-291950-9gtsqyfj	287	17	.	.	.
cord-291950-9gtsqyfj	288	1	However	however	RB
cord-291950-9gtsqyfj	288	2	,	,	,
cord-291950-9gtsqyfj	288	3	a	a	DT
cord-291950-9gtsqyfj	288	4	cysteine	cysteine	NN
cord-291950-9gtsqyfj	288	5	-	-	HYPH
cord-291950-9gtsqyfj	288	6	type	type	NN
cord-291950-9gtsqyfj	288	7	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	288	8	triad	triad	NN
cord-291950-9gtsqyfj	288	9	(	(	-LRB-
cord-291950-9gtsqyfj	288	10	Cys	Cys	NNP
cord-291950-9gtsqyfj	288	11	,	,	,
cord-291950-9gtsqyfj	288	12	His	-PRON-	PRP$
cord-291950-9gtsqyfj	288	13	,	,	,
cord-291950-9gtsqyfj	288	14	Asp	Asp	NNP
cord-291950-9gtsqyfj	288	15	)	)	-RRB-
cord-291950-9gtsqyfj	288	16	,	,	,
cord-291950-9gtsqyfj	288	17	similar	similar	JJ
cord-291950-9gtsqyfj	288	18	to	to	IN
cord-291950-9gtsqyfj	288	19	that	that	DT
cord-291950-9gtsqyfj	288	20	of	of	IN
cord-291950-9gtsqyfj	288	21	papain	papain	NN
cord-291950-9gtsqyfj	288	22	,	,	,
cord-291950-9gtsqyfj	288	23	has	have	VBZ
cord-291950-9gtsqyfj	288	24	also	also	RB
cord-291950-9gtsqyfj	288	25	been	be	VBN
cord-291950-9gtsqyfj	288	26	proposed	propose	VBN
cord-291950-9gtsqyfj	288	27	[	[	-LRB-
cord-291950-9gtsqyfj	288	28	44	44	CD
cord-291950-9gtsqyfj	288	29	]	]	-RRB-
cord-291950-9gtsqyfj	288	30	,	,	,
cord-291950-9gtsqyfj	288	31	and	and	CC
cord-291950-9gtsqyfj	288	32	family	family	NN
cord-291950-9gtsqyfj	288	33	C71	C71	NNP
cord-291950-9gtsqyfj	288	34	is	be	VBZ
cord-291950-9gtsqyfj	288	35	included	include	VBN
cord-291950-9gtsqyfj	288	36	in	in	IN
cord-291950-9gtsqyfj	288	37	clan	clan	NN
cord-291950-9gtsqyfj	288	38	CA	CA	NNP
cord-291950-9gtsqyfj	288	39	.	.	.
cord-291950-9gtsqyfj	289	1	A	a	DT
cord-291950-9gtsqyfj	289	2	second	second	JJ
cord-291950-9gtsqyfj	289	3	clan	clan	NN
cord-291950-9gtsqyfj	289	4	of	of	IN
cord-291950-9gtsqyfj	289	5	cysteine	cysteine	NN
cord-291950-9gtsqyfj	289	6	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	289	7	contains	contain	VBZ
cord-291950-9gtsqyfj	289	8	processing	processing	NN
cord-291950-9gtsqyfj	289	9	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	289	10	of	of	IN
cord-291950-9gtsqyfj	289	11	RNA	RNA	NNP
cord-291950-9gtsqyfj	289	12	viruses	virus	NNS
cord-291950-9gtsqyfj	289	13	.	.	.
cord-291950-9gtsqyfj	290	1	Formerly	formerly	RB
cord-291950-9gtsqyfj	290	2	termed	term	VBN
cord-291950-9gtsqyfj	290	3	clan	clan	NN
cord-291950-9gtsqyfj	290	4	CB	CB	NNP
cord-291950-9gtsqyfj	291	1	,	,	,
cord-291950-9gtsqyfj	291	2	this	this	DT
cord-291950-9gtsqyfj	291	3	has	have	VBZ
cord-291950-9gtsqyfj	291	4	the	the	DT
cord-291950-9gtsqyfj	291	5	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	291	6	dyad	dyad	NN
cord-291950-9gtsqyfj	291	7	in	in	IN
cord-291950-9gtsqyfj	291	8	the	the	DT
cord-291950-9gtsqyfj	291	9	order	order	NN
cord-291950-9gtsqyfj	291	10	His	-PRON-	PRP$
cord-291950-9gtsqyfj	291	11	,	,	,
cord-291950-9gtsqyfj	291	12	Cys	Cys	NNP
cord-291950-9gtsqyfj	291	13	in	in	IN
cord-291950-9gtsqyfj	291	14	the	the	DT
cord-291950-9gtsqyfj	291	15	sequence	sequence	NN
cord-291950-9gtsqyfj	291	16	.	.	.
cord-291950-9gtsqyfj	292	1	A	a	DT
cord-291950-9gtsqyfj	292	2	comparison	comparison	NN
cord-291950-9gtsqyfj	292	3	of	of	IN
cord-291950-9gtsqyfj	292	4	sequence	sequence	NN
cord-291950-9gtsqyfj	292	5	motifs	motif	NNS
cord-291950-9gtsqyfj	292	6	led	lead	VBD
cord-291950-9gtsqyfj	292	7	Bazan	Bazan	NNP
cord-291950-9gtsqyfj	292	8	and	and	CC
cord-291950-9gtsqyfj	292	9	Fletterick	Fletterick	NNP
cord-291950-9gtsqyfj	292	10	[	[	-LRB-
cord-291950-9gtsqyfj	292	11	45	45	CD
cord-291950-9gtsqyfj	292	12	]	]	-RRB-
cord-291950-9gtsqyfj	292	13	to	to	TO
cord-291950-9gtsqyfj	292	14	suggest	suggest	VB
cord-291950-9gtsqyfj	292	15	that	that	IN
cord-291950-9gtsqyfj	292	16	the	the	DT
cord-291950-9gtsqyfj	292	17	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	292	18	processing	process	VBG
cord-291950-9gtsqyfj	292	19	cysteine	cysteine	NN
cord-291950-9gtsqyfj	292	20	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	292	21	of	of	IN
cord-291950-9gtsqyfj	292	22	several	several	JJ
cord-291950-9gtsqyfj	292	23	single	single	JJ
cord-291950-9gtsqyfj	292	24	,	,	,
cord-291950-9gtsqyfj	292	25	positive	positive	JJ
cord-291950-9gtsqyfj	292	26	-	-	HYPH
cord-291950-9gtsqyfj	292	27	stranded	strand	VBN
cord-291950-9gtsqyfj	292	28	RNA	RNA	NNP
cord-291950-9gtsqyfj	292	29	viruses	virus	NNS
cord-291950-9gtsqyfj	292	30	were	be	VBD
cord-291950-9gtsqyfj	292	31	structurally	structurally	RB
cord-291950-9gtsqyfj	292	32	related	relate	VBN
cord-291950-9gtsqyfj	292	33	to	to	IN
cord-291950-9gtsqyfj	292	34	chymotrypsin	chymotrypsin	NNP
cord-291950-9gtsqyfj	292	35	,	,	,
cord-291950-9gtsqyfj	292	36	and	and	CC
cord-291950-9gtsqyfj	292	37	this	this	DT
cord-291950-9gtsqyfj	292	38	was	be	VBD
cord-291950-9gtsqyfj	292	39	confirmed	confirm	VBN
cord-291950-9gtsqyfj	292	40	when	when	WRB
cord-291950-9gtsqyfj	292	41	the	the	DT
cord-291950-9gtsqyfj	292	42	crystal	crystal	NN
cord-291950-9gtsqyfj	292	43	structures	structure	NNS
cord-291950-9gtsqyfj	292	44	of	of	IN
cord-291950-9gtsqyfj	292	45	picornains	picornains	NNP
cord-291950-9gtsqyfj	292	46	3C	3C	NNP
cord-291950-9gtsqyfj	292	47	from	from	IN
cord-291950-9gtsqyfj	292	48	human	human	JJ
cord-291950-9gtsqyfj	292	49	hepatitis	hepatitis	NNP
cord-291950-9gtsqyfj	292	50	A	A	NNP
cord-291950-9gtsqyfj	292	51	virus	virus	NN
cord-291950-9gtsqyfj	292	52	(	(	-LRB-
cord-291950-9gtsqyfj	292	53	Chapter	chapter	NN
cord-291950-9gtsqyfj	292	54	541	541	CD
cord-291950-9gtsqyfj	292	55	)	)	-RRB-
cord-291950-9gtsqyfj	292	56	(	(	-LRB-
cord-291950-9gtsqyfj	292	57	Figure	figure	NN
cord-291950-9gtsqyfj	292	58	404	404	CD
cord-291950-9gtsqyfj	292	59	.20	.20	.
cord-291950-9gtsqyfj	292	60	)	)	-RRB-
cord-291950-9gtsqyfj	292	61	and	and	CC
cord-291950-9gtsqyfj	292	62	human	human	JJ
cord-291950-9gtsqyfj	292	63	rhinovirus	rhinovirus	NN
cord-291950-9gtsqyfj	292	64	type	type	NN
cord-291950-9gtsqyfj	292	65	14	14	CD
cord-291950-9gtsqyfj	293	1	(	(	-LRB-
cord-291950-9gtsqyfj	293	2	Chapter	chapter	NN
cord-291950-9gtsqyfj	293	3	537	537	CD
cord-291950-9gtsqyfj	293	4	)	)	-RRB-
cord-291950-9gtsqyfj	293	5	were	be	VBD
cord-291950-9gtsqyfj	293	6	found	find	VBN
cord-291950-9gtsqyfj	293	7	to	to	TO
cord-291950-9gtsqyfj	293	8	share	share	VB
cord-291950-9gtsqyfj	293	9	the	the	DT
cord-291950-9gtsqyfj	293	10	two	two	CD
cord-291950-9gtsqyfj	293	11	β	β	NN
cord-291950-9gtsqyfj	293	12	-	-	HYPH
cord-291950-9gtsqyfj	293	13	barrel	barrel	NN
cord-291950-9gtsqyfj	293	14	fold	fold	NN
cord-291950-9gtsqyfj	293	15	of	of	IN
cord-291950-9gtsqyfj	293	16	chymotrypsin	chymotrypsin	NNP
cord-291950-9gtsqyfj	293	17	.	.	.
cord-291950-9gtsqyfj	294	1	There	there	EX
cord-291950-9gtsqyfj	294	2	now	now	RB
cord-291950-9gtsqyfj	294	3	seems	seem	VBZ
cord-291950-9gtsqyfj	294	4	no	no	DT
cord-291950-9gtsqyfj	294	5	doubt	doubt	NN
cord-291950-9gtsqyfj	294	6	that	that	IN
cord-291950-9gtsqyfj	294	7	these	these	DT
cord-291950-9gtsqyfj	294	8	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	294	9	have	have	VBP
cord-291950-9gtsqyfj	294	10	evolved	evolve	VBN
cord-291950-9gtsqyfj	294	11	from	from	IN
cord-291950-9gtsqyfj	294	12	a	a	DT
cord-291950-9gtsqyfj	294	13	common	common	JJ
cord-291950-9gtsqyfj	294	14	ancestor	ancestor	NN
cord-291950-9gtsqyfj	294	15	with	with	IN
cord-291950-9gtsqyfj	294	16	chymotrypsin	chymotrypsin	NNP
cord-291950-9gtsqyfj	294	17	.	.	.
cord-291950-9gtsqyfj	295	1	The	the	DT
cord-291950-9gtsqyfj	295	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	295	3	His	His	NNP
cord-291950-9gtsqyfj	295	4	of	of	IN
cord-291950-9gtsqyfj	295	5	picornain	picornain	NNP
cord-291950-9gtsqyfj	295	6	3C	3C	NNP
cord-291950-9gtsqyfj	295	7	(	(	-LRB-
cord-291950-9gtsqyfj	295	8	in	in	IN
cord-291950-9gtsqyfj	295	9	family	family	NN
cord-291950-9gtsqyfj	295	10	C3	C3	NNP
cord-291950-9gtsqyfj	295	11	)	)	-RRB-
cord-291950-9gtsqyfj	295	12	is	be	VBZ
cord-291950-9gtsqyfj	295	13	equivalent	equivalent	JJ
cord-291950-9gtsqyfj	295	14	in	in	IN
cord-291950-9gtsqyfj	295	15	position	position	NN
cord-291950-9gtsqyfj	295	16	to	to	IN
cord-291950-9gtsqyfj	295	17	His57	His57	NNP
cord-291950-9gtsqyfj	295	18	of	of	IN
cord-291950-9gtsqyfj	295	19	chymotrypsin	chymotrypsin	NNP
cord-291950-9gtsqyfj	295	20	,	,	,
cord-291950-9gtsqyfj	295	21	and	and	CC
cord-291950-9gtsqyfj	295	22	the	the	DT
cord-291950-9gtsqyfj	295	23	Cys	Cys	NNP
cord-291950-9gtsqyfj	295	24	replaces	replace	VBZ
cord-291950-9gtsqyfj	295	25	Ser195	ser195	CD
cord-291950-9gtsqyfj	295	26	(	(	-LRB-
cord-291950-9gtsqyfj	295	27	see	see	VB
cord-291950-9gtsqyfj	295	28	the	the	DT
cord-291950-9gtsqyfj	295	29	representation	representation	NN
cord-291950-9gtsqyfj	295	30	of	of	IN
cord-291950-9gtsqyfj	295	31	two	two	CD
cord-291950-9gtsqyfj	295	32	-	-	HYPH
cord-291950-9gtsqyfj	295	33	dimensional	dimensional	JJ
cord-291950-9gtsqyfj	295	34	structures	structure	NNS
cord-291950-9gtsqyfj	295	35	for	for	IN
cord-291950-9gtsqyfj	295	36	clan	clan	NN
cord-291950-9gtsqyfj	295	37	PA	PA	NNP
cord-291950-9gtsqyfj	295	38	,	,	,
cord-291950-9gtsqyfj	295	39	see	see	VB
cord-291950-9gtsqyfj	295	40	Figure	figure	NN
cord-291950-9gtsqyfj	295	41	559	559	CD
cord-291950-9gtsqyfj	295	42	.2	.2	CD
cord-291950-9gtsqyfj	295	43	)	)	-RRB-
cord-291950-9gtsqyfj	295	44	.	.	.
cord-291950-9gtsqyfj	296	1	In	in	IN
cord-291950-9gtsqyfj	296	2	rhinovirus	rhinovirus	JJ
cord-291950-9gtsqyfj	296	3	picornain	picornain	NNP
cord-291950-9gtsqyfj	296	4	2A	2A	NNP
cord-291950-9gtsqyfj	296	5	a	a	DT
cord-291950-9gtsqyfj	296	6	His	His	NNP
cord-291950-9gtsqyfj	296	7	,	,	,
cord-291950-9gtsqyfj	296	8	Asp	Asp	NNP
cord-291950-9gtsqyfj	296	9	,	,	,
cord-291950-9gtsqyfj	296	10	Cys	Cys	NNP
cord-291950-9gtsqyfj	296	11	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	296	12	triad	triad	NN
cord-291950-9gtsqyfj	296	13	is	be	VBZ
cord-291950-9gtsqyfj	296	14	seen	see	VBN
cord-291950-9gtsqyfj	296	15	[	[	-LRB-
cord-291950-9gtsqyfj	296	16	46	46	CD
cord-291950-9gtsqyfj	296	17	]	]	-RRB-
cord-291950-9gtsqyfj	296	18	,	,	,
cord-291950-9gtsqyfj	296	19	but	but	CC
cord-291950-9gtsqyfj	296	20	the	the	DT
cord-291950-9gtsqyfj	296	21	Asp	Asp	NNP
cord-291950-9gtsqyfj	296	22	is	be	VBZ
cord-291950-9gtsqyfj	296	23	replaced	replace	VBN
cord-291950-9gtsqyfj	296	24	by	by	IN
cord-291950-9gtsqyfj	296	25	Glu	Glu	NNP
cord-291950-9gtsqyfj	296	26	in	in	IN
cord-291950-9gtsqyfj	296	27	some	some	DT
cord-291950-9gtsqyfj	296	28	other	other	JJ
cord-291950-9gtsqyfj	296	29	members	member	NNS
cord-291950-9gtsqyfj	296	30	of	of	IN
cord-291950-9gtsqyfj	296	31	family	family	NN
cord-291950-9gtsqyfj	296	32	C3	c3	NN
cord-291950-9gtsqyfj	296	33	.	.	.
cord-291950-9gtsqyfj	297	1	The	the	DT
cord-291950-9gtsqyfj	297	2	viral	viral	JJ
cord-291950-9gtsqyfj	297	3	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	297	4	and	and	CC
cord-291950-9gtsqyfj	297	5	chymotrypsin	chymotrypsin	NNP
cord-291950-9gtsqyfj	297	6	clearly	clearly	RB
cord-291950-9gtsqyfj	297	7	belong	belong	VBP
cord-291950-9gtsqyfj	297	8	in	in	IN
cord-291950-9gtsqyfj	297	9	the	the	DT
cord-291950-9gtsqyfj	297	10	same	same	JJ
cord-291950-9gtsqyfj	297	11	clan	clan	NN
cord-291950-9gtsqyfj	297	12	,	,	,
cord-291950-9gtsqyfj	297	13	and	and	CC
cord-291950-9gtsqyfj	297	14	because	because	IN
cord-291950-9gtsqyfj	297	15	the	the	DT
cord-291950-9gtsqyfj	297	16	clan	clan	NN
cord-291950-9gtsqyfj	297	17	contains	contain	VBZ
cord-291950-9gtsqyfj	297	18	both	both	DT
cord-291950-9gtsqyfj	297	19	cysteine	cysteine	NN
cord-291950-9gtsqyfj	297	20	-	-	HYPH
cord-291950-9gtsqyfj	297	21	type	type	NN
cord-291950-9gtsqyfj	297	22	and	and	CC
cord-291950-9gtsqyfj	297	23	serine	serine	NN
cord-291950-9gtsqyfj	297	24	-	-	HYPH
cord-291950-9gtsqyfj	297	25	type	type	NN
cord-291950-9gtsqyfj	297	26	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	297	27	it	-PRON-	PRP
cord-291950-9gtsqyfj	297	28	has	have	VBZ
cord-291950-9gtsqyfj	297	29	been	be	VBN
cord-291950-9gtsqyfj	297	30	named	name	VBN
cord-291950-9gtsqyfj	297	31	clan	clan	NN
cord-291950-9gtsqyfj	297	32	PA	PA	NNP
cord-291950-9gtsqyfj	297	33	.	.	.
cord-291950-9gtsqyfj	298	1	The	the	DT
cord-291950-9gtsqyfj	298	2	clan	clan	NN
cord-291950-9gtsqyfj	298	3	is	be	VBZ
cord-291950-9gtsqyfj	298	4	divided	divide	VBN
cord-291950-9gtsqyfj	298	5	into	into	IN
cord-291950-9gtsqyfj	298	6	subclan	subclan	NNP
cord-291950-9gtsqyfj	298	7	PA(S	PA(S	NNP
cord-291950-9gtsqyfj	298	8	)	)	-RRB-
cord-291950-9gtsqyfj	298	9	,	,	,
cord-291950-9gtsqyfj	298	10	for	for	IN
cord-291950-9gtsqyfj	298	11	the	the	DT
cord-291950-9gtsqyfj	298	12	serine	serine	NN
cord-291950-9gtsqyfj	298	13	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	298	14	,	,	,
cord-291950-9gtsqyfj	298	15	and	and	CC
cord-291950-9gtsqyfj	298	16	subclan	subclan	NNP
cord-291950-9gtsqyfj	298	17	PA(C	pa(c	CD
cord-291950-9gtsqyfj	298	18	)	)	-RRB-
cord-291950-9gtsqyfj	298	19	for	for	IN
cord-291950-9gtsqyfj	298	20	the	the	DT
cord-291950-9gtsqyfj	298	21	cysteine	cysteine	NN
cord-291950-9gtsqyfj	298	22	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	298	23	.	.	.
cord-291950-9gtsqyfj	299	1	Families	family	NNS
cord-291950-9gtsqyfj	299	2	C4	C4	NNP
cord-291950-9gtsqyfj	299	3	,	,	,
cord-291950-9gtsqyfj	299	4	C24	C24	NNP
cord-291950-9gtsqyfj	299	5	,	,	,
cord-291950-9gtsqyfj	299	6	C30	C30	NNP
cord-291950-9gtsqyfj	299	7	,	,	,
cord-291950-9gtsqyfj	299	8	C37	C37	NNP
cord-291950-9gtsqyfj	299	9	and	and	CC
cord-291950-9gtsqyfj	299	10	C38	C38	NNP
cord-291950-9gtsqyfj	299	11	also	also	RB
cord-291950-9gtsqyfj	299	12	contain	contain	VBP
cord-291950-9gtsqyfj	299	13	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	299	14	from	from	IN
cord-291950-9gtsqyfj	299	15	RNA	RNA	NNP
cord-291950-9gtsqyfj	299	16	viruses	virus	NNS
cord-291950-9gtsqyfj	299	17	that	that	WDT
cord-291950-9gtsqyfj	299	18	are	be	VBP
cord-291950-9gtsqyfj	299	19	predicted	predict	VBN
cord-291950-9gtsqyfj	299	20	to	to	TO
cord-291950-9gtsqyfj	299	21	have	have	VB
cord-291950-9gtsqyfj	299	22	the	the	DT
cord-291950-9gtsqyfj	299	23	chymotrypsin	chymotrypsin	NN
cord-291950-9gtsqyfj	299	24	fold	fold	VB
cord-291950-9gtsqyfj	299	25	,	,	,
cord-291950-9gtsqyfj	299	26	and	and	CC
cord-291950-9gtsqyfj	299	27	are	be	VBP
cord-291950-9gtsqyfj	299	28	placed	place	VBN
cord-291950-9gtsqyfj	299	29	in	in	IN
cord-291950-9gtsqyfj	299	30	subclan	subclan	NNP
cord-291950-9gtsqyfj	299	31	PA(C	PA(C	NNP
cord-291950-9gtsqyfj	299	32	)	)	-RRB-
cord-291950-9gtsqyfj	299	33	together	together	RB
cord-291950-9gtsqyfj	299	34	with	with	IN
cord-291950-9gtsqyfj	299	35	family	family	NN
cord-291950-9gtsqyfj	299	36	C3	c3	NN
cord-291950-9gtsqyfj	299	37	.	.	.
cord-291950-9gtsqyfj	300	1	The	the	DT
cord-291950-9gtsqyfj	300	2	viral	viral	JJ
cord-291950-9gtsqyfj	300	3	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	300	4	in	in	IN
cord-291950-9gtsqyfj	300	5	subclan	subclan	NNP
cord-291950-9gtsqyfj	300	6	PA(C	pa(c	CD
cord-291950-9gtsqyfj	300	7	)	)	-RRB-
cord-291950-9gtsqyfj	300	8	contrast	contrast	NN
cord-291950-9gtsqyfj	300	9	in	in	IN
cord-291950-9gtsqyfj	300	10	several	several	JJ
cord-291950-9gtsqyfj	300	11	respects	respect	NNS
cord-291950-9gtsqyfj	300	12	with	with	IN
cord-291950-9gtsqyfj	300	13	those	those	DT
cord-291950-9gtsqyfj	300	14	in	in	IN
cord-291950-9gtsqyfj	300	15	clan	clan	NN
cord-291950-9gtsqyfj	300	16	CA	CA	NNP
cord-291950-9gtsqyfj	300	17	.	.	.
cord-291950-9gtsqyfj	301	1	In	in	IN
cord-291950-9gtsqyfj	301	2	subclan	subclan	NNP
cord-291950-9gtsqyfj	301	3	PA(C	pa(c	CD
cord-291950-9gtsqyfj	301	4	)	)	-RRB-
cord-291950-9gtsqyfj	301	5	the	the	DT
cord-291950-9gtsqyfj	301	6	active	active	JJ
cord-291950-9gtsqyfj	301	7	site	site	NN
cord-291950-9gtsqyfj	301	8	Cys	Cys	NNP
cord-291950-9gtsqyfj	301	9	is	be	VBZ
cord-291950-9gtsqyfj	301	10	followed	follow	VBN
cord-291950-9gtsqyfj	301	11	by	by	IN
cord-291950-9gtsqyfj	301	12	Gly	Gly	NNP
cord-291950-9gtsqyfj	301	13	(	(	-LRB-
cord-291950-9gtsqyfj	301	14	like	like	IN
cord-291950-9gtsqyfj	301	15	the	the	DT
cord-291950-9gtsqyfj	301	16	Ser	Ser	NNP
cord-291950-9gtsqyfj	301	17	in	in	IN
cord-291950-9gtsqyfj	301	18	chymotrypsin	chymotrypsin	NNP
cord-291950-9gtsqyfj	301	19	)	)	-RRB-
cord-291950-9gtsqyfj	301	20	whereas	whereas	IN
cord-291950-9gtsqyfj	301	21	in	in	IN
cord-291950-9gtsqyfj	301	22	clan	clan	NN
cord-291950-9gtsqyfj	301	23	CA	CA	NNP
cord-291950-9gtsqyfj	301	24	the	the	DT
cord-291950-9gtsqyfj	301	25	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	301	26	Cys	Cys	NNP
cord-291950-9gtsqyfj	301	27	is	be	VBZ
cord-291950-9gtsqyfj	301	28	generally	generally	RB
cord-291950-9gtsqyfj	301	29	followed	follow	VBN
cord-291950-9gtsqyfj	301	30	by	by	IN
cord-291950-9gtsqyfj	301	31	a	a	DT
cord-291950-9gtsqyfj	301	32	large	large	JJ
cord-291950-9gtsqyfj	301	33	hydrophobic	hydrophobic	JJ
cord-291950-9gtsqyfj	301	34	residue	residue	NN
cord-291950-9gtsqyfj	301	35	.	.	.
cord-291950-9gtsqyfj	302	1	As	as	IN
cord-291950-9gtsqyfj	302	2	regards	regard	NNS
cord-291950-9gtsqyfj	302	3	function	function	NN
cord-291950-9gtsqyfj	302	4	,	,	,
cord-291950-9gtsqyfj	302	5	the	the	DT
cord-291950-9gtsqyfj	302	6	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	302	7	of	of	IN
cord-291950-9gtsqyfj	302	8	subclan	subclan	NNP
cord-291950-9gtsqyfj	302	9	PA(C	pa(c	CD
cord-291950-9gtsqyfj	302	10	)	)	-RRB-
cord-291950-9gtsqyfj	302	11	tend	tend	VBP
cord-291950-9gtsqyfj	302	12	to	to	TO
cord-291950-9gtsqyfj	302	13	be	be	VB
cord-291950-9gtsqyfj	302	14	general	general	JJ
cord-291950-9gtsqyfj	302	15	processing	processing	NN
cord-291950-9gtsqyfj	302	16	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	302	17	,	,	,
cord-291950-9gtsqyfj	302	18	cleaving	cleave	VBG
cord-291950-9gtsqyfj	302	19	several	several	JJ
cord-291950-9gtsqyfj	302	20	bonds	bond	NNS
cord-291950-9gtsqyfj	302	21	in	in	IN
cord-291950-9gtsqyfj	302	22	the	the	DT
cord-291950-9gtsqyfj	302	23	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	302	24	,	,	,
cord-291950-9gtsqyfj	302	25	whereas	whereas	IN
cord-291950-9gtsqyfj	302	26	those	those	DT
cord-291950-9gtsqyfj	302	27	in	in	IN
cord-291950-9gtsqyfj	302	28	clan	clan	NN
cord-291950-9gtsqyfj	302	29	CA	CA	MD
cord-291950-9gtsqyfj	302	30	generally	generally	RB
cord-291950-9gtsqyfj	302	31	perform	perform	VBP
cord-291950-9gtsqyfj	302	32	only	only	RB
cord-291950-9gtsqyfj	302	33	a	a	DT
cord-291950-9gtsqyfj	302	34	single	single	JJ
cord-291950-9gtsqyfj	302	35	cleavage	cleavage	NN
cord-291950-9gtsqyfj	302	36	.	.	.
cord-291950-9gtsqyfj	303	1	There	there	EX
cord-291950-9gtsqyfj	303	2	is	be	VBZ
cord-291950-9gtsqyfj	303	3	also	also	RB
cord-291950-9gtsqyfj	303	4	a	a	DT
cord-291950-9gtsqyfj	303	5	difference	difference	NN
cord-291950-9gtsqyfj	303	6	in	in	IN
cord-291950-9gtsqyfj	303	7	P1	P1	NNP
cord-291950-9gtsqyfj	303	8	substrate	substrate	NN
cord-291950-9gtsqyfj	303	9	specificity	specificity	NN
cord-291950-9gtsqyfj	303	10	:	:	:
cord-291950-9gtsqyfj	303	11	in	in	IN
cord-291950-9gtsqyfj	303	12	subclan	subclan	NNP
cord-291950-9gtsqyfj	303	13	PA(C	pa(c	CD
cord-291950-9gtsqyfj	303	14	)	)	-RRB-
cord-291950-9gtsqyfj	303	15	cleavage	cleavage	NN
cord-291950-9gtsqyfj	303	16	is	be	VBZ
cord-291950-9gtsqyfj	303	17	commonly	commonly	RB
cord-291950-9gtsqyfj	303	18	at	at	IN
cord-291950-9gtsqyfj	303	19	a	a	DT
cord-291950-9gtsqyfj	303	20	GlnkGly	GlnkGly	NNP
cord-291950-9gtsqyfj	303	21	bond	bond	NN
cord-291950-9gtsqyfj	303	22	,	,	,
cord-291950-9gtsqyfj	303	23	whereas	whereas	IN
cord-291950-9gtsqyfj	303	24	in	in	IN
cord-291950-9gtsqyfj	303	25	clan	clan	NN
cord-291950-9gtsqyfj	303	26	CA	CA	NNP
cord-291950-9gtsqyfj	303	27	cleavage	cleavage	NN
cord-291950-9gtsqyfj	303	28	usually	usually	RB
cord-291950-9gtsqyfj	303	29	occurs	occur	VBZ
cord-291950-9gtsqyfj	303	30	at	at	IN
cord-291950-9gtsqyfj	303	31	a	a	DT
cord-291950-9gtsqyfj	303	32	GlykGly	GlykGly	NNP
cord-291950-9gtsqyfj	303	33	bond	bond	NN
cord-291950-9gtsqyfj	303	34	.	.	.
cord-291950-9gtsqyfj	304	1	The	the	DT
cord-291950-9gtsqyfj	304	2	subclan	subclan	NNP
cord-291950-9gtsqyfj	304	3	PA	PA	NNP
cord-291950-9gtsqyfj	304	4	(	(	-LRB-
cord-291950-9gtsqyfj	304	5	C	C	NNP
cord-291950-9gtsqyfj	304	6	)	)	-RRB-
cord-291950-9gtsqyfj	304	7	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	304	8	is	be	VBZ
cord-291950-9gtsqyfj	304	9	usually	usually	RB
cord-291950-9gtsqyfj	304	10	positioned	position	VBN
cord-291950-9gtsqyfj	304	11	between	between	IN
cord-291950-9gtsqyfj	304	12	the	the	DT
cord-291950-9gtsqyfj	304	13	helicase	helicase	NN
cord-291950-9gtsqyfj	304	14	and	and	CC
cord-291950-9gtsqyfj	304	15	the	the	DT
cord-291950-9gtsqyfj	304	16	RNA	RNA	NNP
cord-291950-9gtsqyfj	304	17	polymerase	polymerase	NN
cord-291950-9gtsqyfj	304	18	in	in	IN
cord-291950-9gtsqyfj	304	19	the	the	DT
cord-291950-9gtsqyfj	304	20	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	304	21	,	,	,
cord-291950-9gtsqyfj	304	22	whereas	whereas	IN
cord-291950-9gtsqyfj	304	23	the	the	DT
cord-291950-9gtsqyfj	304	24	clan	clan	NN
cord-291950-9gtsqyfj	304	25	CA	CA	NNP
cord-291950-9gtsqyfj	304	26	enzyme	enzyme	NN
cord-291950-9gtsqyfj	304	27	usually	usually	RB
cord-291950-9gtsqyfj	304	28	precedes	precede	VBZ
cord-291950-9gtsqyfj	304	29	both	both	CC
cord-291950-9gtsqyfj	304	30	the	the	DT
cord-291950-9gtsqyfj	304	31	helicase	helicase	NN
cord-291950-9gtsqyfj	304	32	and	and	CC
cord-291950-9gtsqyfj	304	33	the	the	DT
cord-291950-9gtsqyfj	304	34	RNA	RNA	NNP
cord-291950-9gtsqyfj	304	35	polymerase	polymerase	NN
cord-291950-9gtsqyfj	304	36	.	.	.
cord-291950-9gtsqyfj	305	1	Taken	take	VBN
cord-291950-9gtsqyfj	305	2	together	together	RB
cord-291950-9gtsqyfj	305	3	with	with	IN
cord-291950-9gtsqyfj	305	4	other	other	JJ
cord-291950-9gtsqyfj	305	5	indications	indication	NNS
cord-291950-9gtsqyfj	305	6	that	that	IN
cord-291950-9gtsqyfj	305	7	the	the	DT
cord-291950-9gtsqyfj	305	8	positive	positive	NN
cord-291950-9gtsqyfj	305	9	-	-	HYPH
cord-291950-9gtsqyfj	305	10	stranded	strand	VBN
cord-291950-9gtsqyfj	305	11	RNA	RNA	NNP
cord-291950-9gtsqyfj	305	12	viruses	virus	NNS
cord-291950-9gtsqyfj	305	13	are	be	VBP
cord-291950-9gtsqyfj	305	14	evolutionarily	evolutionarily	RB
cord-291950-9gtsqyfj	305	15	related	relate	VBN
cord-291950-9gtsqyfj	305	16	,	,	,
cord-291950-9gtsqyfj	305	17	the	the	DT
cord-291950-9gtsqyfj	305	18	similar	similar	JJ
cord-291950-9gtsqyfj	305	19	locations	location	NNS
cord-291950-9gtsqyfj	305	20	of	of	IN
cord-291950-9gtsqyfj	305	21	the	the	DT
cord-291950-9gtsqyfj	305	22	subclan	subclan	NNP
cord-291950-9gtsqyfj	305	23	PA	PA	NNP
cord-291950-9gtsqyfj	305	24	(	(	-LRB-
cord-291950-9gtsqyfj	305	25	C	C	NNP
cord-291950-9gtsqyfj	305	26	)	)	-RRB-
cord-291950-9gtsqyfj	305	27	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	305	28	in	in	IN
cord-291950-9gtsqyfj	305	29	the	the	DT
cord-291950-9gtsqyfj	305	30	genomes	genome	NNS
cord-291950-9gtsqyfj	305	31	is	be	VBZ
cord-291950-9gtsqyfj	305	32	entirely	entirely	RB
cord-291950-9gtsqyfj	305	33	consistent	consistent	JJ
cord-291950-9gtsqyfj	305	34	with	with	IN
cord-291950-9gtsqyfj	305	35	a	a	DT
cord-291950-9gtsqyfj	305	36	common	common	JJ
cord-291950-9gtsqyfj	305	37	evolutionary	evolutionary	JJ
cord-291950-9gtsqyfj	305	38	origin	origin	NN
cord-291950-9gtsqyfj	305	39	of	of	IN
cord-291950-9gtsqyfj	305	40	all	all	DT
cord-291950-9gtsqyfj	305	41	of	of	IN
cord-291950-9gtsqyfj	305	42	the	the	DT
cord-291950-9gtsqyfj	305	43	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	305	44	in	in	IN
cord-291950-9gtsqyfj	305	45	the	the	DT
cord-291950-9gtsqyfj	305	46	subclan	subclan	NNP
cord-291950-9gtsqyfj	305	47	.	.	.
cord-291950-9gtsqyfj	306	1	The	the	DT
cord-291950-9gtsqyfj	306	2	high	high	JJ
cord-291950-9gtsqyfj	306	3	rate	rate	NN
cord-291950-9gtsqyfj	306	4	of	of	IN
cord-291950-9gtsqyfj	306	5	mutation	mutation	NN
cord-291950-9gtsqyfj	306	6	of	of	IN
cord-291950-9gtsqyfj	306	7	RNA	RNA	NNP
cord-291950-9gtsqyfj	306	8	viruses	virus	NNS
cord-291950-9gtsqyfj	306	9	,	,	,
cord-291950-9gtsqyfj	306	10	lacking	lack	VBG
cord-291950-9gtsqyfj	306	11	proofreading	proofreading	NN
cord-291950-9gtsqyfj	306	12	in	in	IN
cord-291950-9gtsqyfj	306	13	the	the	DT
cord-291950-9gtsqyfj	306	14	replication	replication	NN
cord-291950-9gtsqyfj	306	15	of	of	IN
cord-291950-9gtsqyfj	306	16	the	the	DT
cord-291950-9gtsqyfj	306	17	genome	genome	NN
cord-291950-9gtsqyfj	306	18	,	,	,
cord-291950-9gtsqyfj	306	19	could	could	MD
cord-291950-9gtsqyfj	306	20	rapidly	rapidly	RB
cord-291950-9gtsqyfj	306	21	have	have	VB
cord-291950-9gtsqyfj	306	22	obscured	obscure	VBN
cord-291950-9gtsqyfj	306	23	sequence	sequence	NN
cord-291950-9gtsqyfj	306	24	relationships	relationship	NNS
cord-291950-9gtsqyfj	306	25	between	between	IN
cord-291950-9gtsqyfj	306	26	the	the	DT
cord-291950-9gtsqyfj	306	27	sequences	sequence	NNS
cord-291950-9gtsqyfj	306	28	.	.	.
cord-291950-9gtsqyfj	307	1	Family	family	NN
cord-291950-9gtsqyfj	307	2	C3	C3	NNP
cord-291950-9gtsqyfj	307	3	contains	contain	VBZ
cord-291950-9gtsqyfj	307	4	the	the	DT
cord-291950-9gtsqyfj	307	5	processing	processing	NN
cord-291950-9gtsqyfj	307	6	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	307	7	of	of	IN
cord-291950-9gtsqyfj	307	8	picornaviruses	picornavirus	NNS
cord-291950-9gtsqyfj	307	9	,	,	,
cord-291950-9gtsqyfj	307	10	aphthoviruses	aphthoviruses	NNPS
cord-291950-9gtsqyfj	307	11	,	,	,
cord-291950-9gtsqyfj	307	12	nepoviruses	nepoviruses	NNP
cord-291950-9gtsqyfj	307	13	and	and	CC
cord-291950-9gtsqyfj	307	14	comoviruses	comoviruse	NNS
cord-291950-9gtsqyfj	307	15	.	.	.
cord-291950-9gtsqyfj	308	1	The	the	DT
cord-291950-9gtsqyfj	308	2	first	first	JJ
cord-291950-9gtsqyfj	308	3	group	group	NN
cord-291950-9gtsqyfj	308	4	includes	include	VBZ
cord-291950-9gtsqyfj	308	5	animal	animal	NN
cord-291950-9gtsqyfj	308	6	viruses	virus	NNS
cord-291950-9gtsqyfj	308	7	such	such	JJ
cord-291950-9gtsqyfj	308	8	as	as	IN
cord-291950-9gtsqyfj	308	9	those	those	DT
cord-291950-9gtsqyfj	308	10	that	that	WDT
cord-291950-9gtsqyfj	308	11	cause	cause	VBP
cord-291950-9gtsqyfj	308	12	polio	polio	NN
cord-291950-9gtsqyfj	308	13	and	and	CC
cord-291950-9gtsqyfj	308	14	encephalomyocarditis	encephalomyocarditis	NNP
cord-291950-9gtsqyfj	308	15	.	.	.
cord-291950-9gtsqyfj	309	1	Picornaviruses	Picornaviruses	NNP
cord-291950-9gtsqyfj	309	2	encode	encode	VBP
cord-291950-9gtsqyfj	309	3	one	one	CD
cord-291950-9gtsqyfj	309	4	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	309	5	that	that	WDT
cord-291950-9gtsqyfj	309	6	contains	contain	VBZ
cord-291950-9gtsqyfj	309	7	coat	coat	NN
cord-291950-9gtsqyfj	309	8	and	and	CC
cord-291950-9gtsqyfj	309	9	core	core	NN
cord-291950-9gtsqyfj	309	10	proteins	protein	NNS
cord-291950-9gtsqyfj	309	11	,	,	,
cord-291950-9gtsqyfj	309	12	an	an	DT
cord-291950-9gtsqyfj	309	13	RNA	RNA	NNP
cord-291950-9gtsqyfj	309	14	polymerase	polymerase	NN
cord-291950-9gtsqyfj	309	15	and	and	CC
cord-291950-9gtsqyfj	309	16	two	two	CD
cord-291950-9gtsqyfj	309	17	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	309	18	that	that	WDT
cord-291950-9gtsqyfj	309	19	are	be	VBP
cord-291950-9gtsqyfj	309	20	homologous	homologous	JJ
cord-291950-9gtsqyfj	309	21	to	to	IN
cord-291950-9gtsqyfj	309	22	each	each	DT
cord-291950-9gtsqyfj	309	23	other	other	JJ
cord-291950-9gtsqyfj	309	24	and	and	CC
cord-291950-9gtsqyfj	309	25	responsible	responsible	JJ
cord-291950-9gtsqyfj	309	26	for	for	IN
cord-291950-9gtsqyfj	309	27	excising	excise	VBG
cord-291950-9gtsqyfj	309	28	the	the	DT
cord-291950-9gtsqyfj	309	29	individual	individual	JJ
cord-291950-9gtsqyfj	309	30	proteins	protein	NNS
cord-291950-9gtsqyfj	309	31	.	.	.
cord-291950-9gtsqyfj	310	1	The	the	DT
cord-291950-9gtsqyfj	310	2	larger	large	JJR
cord-291950-9gtsqyfj	310	3	of	of	IN
cord-291950-9gtsqyfj	310	4	the	the	DT
cord-291950-9gtsqyfj	310	5	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	310	6	,	,	,
cord-291950-9gtsqyfj	310	7	picornain	picornain	NNP
cord-291950-9gtsqyfj	310	8	3C	3C	NNP
cord-291950-9gtsqyfj	310	9	,	,	,
cord-291950-9gtsqyfj	310	10	is	be	VBZ
cord-291950-9gtsqyfj	310	11	responsible	responsible	JJ
cord-291950-9gtsqyfj	310	12	for	for	IN
cord-291950-9gtsqyfj	310	13	most	most	JJS
cord-291950-9gtsqyfj	310	14	of	of	IN
cord-291950-9gtsqyfj	310	15	the	the	DT
cord-291950-9gtsqyfj	310	16	cleavages	cleavage	NNS
cord-291950-9gtsqyfj	310	17	,	,	,
cord-291950-9gtsqyfj	310	18	mainly	mainly	RB
cord-291950-9gtsqyfj	310	19	at	at	IN
cord-291950-9gtsqyfj	310	20	GlnkGly	GlnkGly	NNP
cord-291950-9gtsqyfj	310	21	bonds	bond	NNS
cord-291950-9gtsqyfj	310	22	,	,	,
cord-291950-9gtsqyfj	310	23	whereas	whereas	IN
cord-291950-9gtsqyfj	310	24	the	the	DT
cord-291950-9gtsqyfj	310	25	smaller	small	JJR
cord-291950-9gtsqyfj	310	26	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	310	27	,	,	,
cord-291950-9gtsqyfj	310	28	picornain	picornain	NNP
cord-291950-9gtsqyfj	310	29	2A	2A	NNP
cord-291950-9gtsqyfj	310	30	,	,	,
cord-291950-9gtsqyfj	310	31	releases	release	VBZ
cord-291950-9gtsqyfj	310	32	itself	-PRON-	PRP
cord-291950-9gtsqyfj	310	33	by	by	IN
cord-291950-9gtsqyfj	310	34	cleavage	cleavage	NN
cord-291950-9gtsqyfj	310	35	of	of	IN
cord-291950-9gtsqyfj	310	36	a	a	DT
cord-291950-9gtsqyfj	310	37	TyrkGly	TyrkGly	NNP
cord-291950-9gtsqyfj	310	38	bond	bond	NN
cord-291950-9gtsqyfj	310	39	.	.	.
cord-291950-9gtsqyfj	311	1	Picornain	Picornain	NNP
cord-291950-9gtsqyfj	311	2	2A	2a	NN
cord-291950-9gtsqyfj	311	3	has	have	VBZ
cord-291950-9gtsqyfj	311	4	the	the	DT
cord-291950-9gtsqyfj	311	5	further	further	JJ
cord-291950-9gtsqyfj	311	6	function	function	NN
cord-291950-9gtsqyfj	311	7	of	of	IN
cord-291950-9gtsqyfj	311	8	cleaving	cleave	VBG
cord-291950-9gtsqyfj	311	9	the	the	DT
cord-291950-9gtsqyfj	311	10	eukaryote	eukaryote	NN
cord-291950-9gtsqyfj	311	11	initiation	initiation	NN
cord-291950-9gtsqyfj	311	12	factor	factor	NN
cord-291950-9gtsqyfj	311	13	4	4	CD
cord-291950-9gtsqyfj	311	14	G	g	NN
cord-291950-9gtsqyfj	311	15	of	of	IN
cord-291950-9gtsqyfj	311	16	the	the	DT
cord-291950-9gtsqyfj	311	17	host	host	NN
cord-291950-9gtsqyfj	311	18	cell	cell	NN
cord-291950-9gtsqyfj	311	19	[	[	-LRB-
cord-291950-9gtsqyfj	311	20	47	47	CD
cord-291950-9gtsqyfj	311	21	]	]	-RRB-
cord-291950-9gtsqyfj	311	22	.	.	.
cord-291950-9gtsqyfj	312	1	Picornaviruses	picornavirus	NNS
cord-291950-9gtsqyfj	312	2	are	be	VBP
cord-291950-9gtsqyfj	312	3	unusual	unusual	JJ
cord-291950-9gtsqyfj	312	4	in	in	IN
cord-291950-9gtsqyfj	312	5	possessing	possess	VBG
cord-291950-9gtsqyfj	312	6	two	two	CD
cord-291950-9gtsqyfj	312	7	homologous	homologous	JJ
cord-291950-9gtsqyfj	312	8	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	312	9	;	;	:
cord-291950-9gtsqyfj	312	10	in	in	IN
cord-291950-9gtsqyfj	312	11	aphthoviruses	aphthoviruse	NNS
cord-291950-9gtsqyfj	312	12	,	,	,
cord-291950-9gtsqyfj	312	13	for	for	IN
cord-291950-9gtsqyfj	312	14	example	example	NN
cord-291950-9gtsqyfj	312	15	,	,	,
cord-291950-9gtsqyfj	312	16	cleavage	cleavage	NN
cord-291950-9gtsqyfj	312	17	of	of	IN
cord-291950-9gtsqyfj	312	18	the	the	DT
cord-291950-9gtsqyfj	312	19	eukaryote	eukaryote	NN
cord-291950-9gtsqyfj	312	20	initiation	initiation	NN
cord-291950-9gtsqyfj	312	21	factor	factor	NN
cord-291950-9gtsqyfj	312	22	4	4	CD
cord-291950-9gtsqyfj	312	23	G	g	NN
cord-291950-9gtsqyfj	312	24	is	be	VBZ
cord-291950-9gtsqyfj	312	25	performed	perform	VBN
cord-291950-9gtsqyfj	312	26	by	by	IN
cord-291950-9gtsqyfj	312	27	an	an	DT
cord-291950-9gtsqyfj	312	28	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	312	29	unrelated	unrelated	JJ
cord-291950-9gtsqyfj	312	30	to	to	IN
cord-291950-9gtsqyfj	312	31	the	the	DT
cord-291950-9gtsqyfj	312	32	picornains	picornain	NNS
cord-291950-9gtsqyfj	312	33	,	,	,
cord-291950-9gtsqyfj	312	34	the	the	DT
cord-291950-9gtsqyfj	312	35	L	l	NN
cord-291950-9gtsqyfj	312	36	-	-	HYPH
cord-291950-9gtsqyfj	312	37	peptidase	peptidase	NN
cord-291950-9gtsqyfj	312	38	of	of	IN
cord-291950-9gtsqyfj	312	39	family	family	NN
cord-291950-9gtsqyfj	312	40	C28	c28	NN
cord-291950-9gtsqyfj	312	41	,	,	,
cord-291950-9gtsqyfj	312	42	clan	clan	NN
cord-291950-9gtsqyfj	312	43	CA	CA	NNP
cord-291950-9gtsqyfj	312	44	(	(	-LRB-
cord-291950-9gtsqyfj	312	45	Chapter	chapter	NN
cord-291950-9gtsqyfj	312	46	491	491	CD
cord-291950-9gtsqyfj	312	47	)	)	-RRB-
cord-291950-9gtsqyfj	312	48	.	.	.
cord-291950-9gtsqyfj	313	1	Although	although	IN
cord-291950-9gtsqyfj	313	2	the	the	DT
cord-291950-9gtsqyfj	313	3	picornains	picornain	NNS
cord-291950-9gtsqyfj	313	4	C3	C3	NNP
cord-291950-9gtsqyfj	313	5	and	and	CC
cord-291950-9gtsqyfj	313	6	2A	2A	NNS
cord-291950-9gtsqyfj	313	7	are	be	VBP
cord-291950-9gtsqyfj	313	8	homologous	homologous	JJ
cord-291950-9gtsqyfj	313	9	,	,	,
cord-291950-9gtsqyfj	313	10	the	the	DT
cord-291950-9gtsqyfj	313	11	sequences	sequence	NNS
cord-291950-9gtsqyfj	313	12	are	be	VBP
cord-291950-9gtsqyfj	313	13	so	so	RB
cord-291950-9gtsqyfj	313	14	different	different	JJ
cord-291950-9gtsqyfj	313	15	that	that	IN
cord-291950-9gtsqyfj	313	16	they	-PRON-	PRP
cord-291950-9gtsqyfj	313	17	are	be	VBP
cord-291950-9gtsqyfj	313	18	assigned	assign	VBN
cord-291950-9gtsqyfj	313	19	to	to	IN
cord-291950-9gtsqyfj	313	20	the	the	DT
cord-291950-9gtsqyfj	313	21	separate	separate	JJ
cord-291950-9gtsqyfj	313	22	subfamilies	subfamily	NNS
cord-291950-9gtsqyfj	313	23	C3A	c3a	NN
cord-291950-9gtsqyfj	313	24	and	and	CC
cord-291950-9gtsqyfj	313	25	C3B	c3b	NN
cord-291950-9gtsqyfj	313	26	,	,	,
cord-291950-9gtsqyfj	313	27	respectively	respectively	RB
cord-291950-9gtsqyfj	313	28	.	.	.
cord-291950-9gtsqyfj	314	1	The	the	DT
cord-291950-9gtsqyfj	314	2	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	314	3	processing	processing	NN
cord-291950-9gtsqyfj	314	4	enzyme	enzyme	NN
cord-291950-9gtsqyfj	314	5	from	from	IN
cord-291950-9gtsqyfj	314	6	aphthoviruses	aphthoviruse	NNS
cord-291950-9gtsqyfj	314	7	,	,	,
cord-291950-9gtsqyfj	314	8	which	which	WDT
cord-291950-9gtsqyfj	314	9	include	include	VBP
cord-291950-9gtsqyfj	314	10	foot	foot	NN
cord-291950-9gtsqyfj	314	11	-	-	HYPH
cord-291950-9gtsqyfj	314	12	and	and	CC
cord-291950-9gtsqyfj	314	13	-	-	HYPH
cord-291950-9gtsqyfj	314	14	mouth	mouth	NN
cord-291950-9gtsqyfj	314	15	disease	disease	NN
cord-291950-9gtsqyfj	314	16	,	,	,
cord-291950-9gtsqyfj	314	17	is	be	VBZ
cord-291950-9gtsqyfj	314	18	so	so	RB
cord-291950-9gtsqyfj	314	19	different	different	JJ
cord-291950-9gtsqyfj	314	20	in	in	IN
cord-291950-9gtsqyfj	314	21	sequence	sequence	NN
cord-291950-9gtsqyfj	314	22	from	from	IN
cord-291950-9gtsqyfj	314	23	the	the	DT
cord-291950-9gtsqyfj	314	24	picornains	picornain	NNS
cord-291950-9gtsqyfj	314	25	that	that	WDT
cord-291950-9gtsqyfj	314	26	it	-PRON-	PRP
cord-291950-9gtsqyfj	314	27	too	too	RB
cord-291950-9gtsqyfj	314	28	is	be	VBZ
cord-291950-9gtsqyfj	314	29	assigned	assign	VBN
cord-291950-9gtsqyfj	314	30	to	to	IN
cord-291950-9gtsqyfj	314	31	a	a	DT
cord-291950-9gtsqyfj	314	32	separate	separate	JJ
cord-291950-9gtsqyfj	314	33	subfamily	subfamily	NN
cord-291950-9gtsqyfj	314	34	,	,	,
cord-291950-9gtsqyfj	314	35	C3C.	C3C.	NNP
cord-291950-9gtsqyfj	315	1	The	the	DT
cord-291950-9gtsqyfj	315	2	processing	processing	NN
cord-291950-9gtsqyfj	315	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	315	4	for	for	IN
cord-291950-9gtsqyfj	315	5	the	the	DT
cord-291950-9gtsqyfj	315	6	hepatitis	hepatitis	NN
cord-291950-9gtsqyfj	315	7	A	A	NNP
cord-291950-9gtsqyfj	315	8	virus	virus	NN
cord-291950-9gtsqyfj	315	9	is	be	VBZ
cord-291950-9gtsqyfj	315	10	a	a	DT
cord-291950-9gtsqyfj	315	11	member	member	NN
cord-291950-9gtsqyfj	315	12	of	of	IN
cord-291950-9gtsqyfj	315	13	a	a	DT
cord-291950-9gtsqyfj	315	14	fourth	fourth	JJ
cord-291950-9gtsqyfj	315	15	subfamily	subfamily	NN
cord-291950-9gtsqyfj	315	16	,	,	,
cord-291950-9gtsqyfj	315	17	C3E	c3e	CD
cord-291950-9gtsqyfj	315	18	,	,	,
cord-291950-9gtsqyfj	315	19	and	and	CC
cord-291950-9gtsqyfj	315	20	a	a	DT
cord-291950-9gtsqyfj	315	21	fifth	fifth	JJ
cord-291950-9gtsqyfj	315	22	subfamily	subfamily	NN
cord-291950-9gtsqyfj	315	23	,	,	,
cord-291950-9gtsqyfj	315	24	C3F	C3F	NNP
cord-291950-9gtsqyfj	315	25	,	,	,
cord-291950-9gtsqyfj	315	26	includes	include	VBZ
cord-291950-9gtsqyfj	315	27	the	the	DT
cord-291950-9gtsqyfj	315	28	protease	protease	NN
cord-291950-9gtsqyfj	315	29	from	from	IN
cord-291950-9gtsqyfj	315	30	parechovirus	parechovirus	NNP
cord-291950-9gtsqyfj	315	31	1	1	CD
cord-291950-9gtsqyfj	315	32	.	.	.
cord-291950-9gtsqyfj	316	1	Not	not	RB
cord-291950-9gtsqyfj	316	2	all	all	DT
cord-291950-9gtsqyfj	316	3	members	member	NNS
cord-291950-9gtsqyfj	316	4	of	of	IN
cord-291950-9gtsqyfj	316	5	family	family	NN
cord-291950-9gtsqyfj	316	6	C3	C3	NNP
cord-291950-9gtsqyfj	316	7	are	be	VBP
cord-291950-9gtsqyfj	316	8	animal	animal	NN
cord-291950-9gtsqyfj	316	9	pathogens	pathogen	NNS
cord-291950-9gtsqyfj	316	10	,	,	,
cord-291950-9gtsqyfj	316	11	and	and	CC
cord-291950-9gtsqyfj	316	12	subfamily	subfamily	RB
cord-291950-9gtsqyfj	316	13	C3D	C3D	NNP
cord-291950-9gtsqyfj	316	14	includes	include	VBZ
cord-291950-9gtsqyfj	316	15	processing	processing	NN
cord-291950-9gtsqyfj	316	16	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	316	17	for	for	IN
cord-291950-9gtsqyfj	316	18	the	the	DT
cord-291950-9gtsqyfj	316	19	polyprotein	polyprotein	NNP
cord-291950-9gtsqyfj	316	20	of	of	IN
cord-291950-9gtsqyfj	316	21	cowpea	cowpea	NNP
cord-291950-9gtsqyfj	316	22	mosaic	mosaic	NNP
cord-291950-9gtsqyfj	316	23	virus	virus	NN
cord-291950-9gtsqyfj	316	24	and	and	CC
cord-291950-9gtsqyfj	316	25	other	other	JJ
cord-291950-9gtsqyfj	316	26	plant	plant	NN
cord-291950-9gtsqyfj	316	27	pathogens	pathogen	NNS
cord-291950-9gtsqyfj	316	28	.	.	.
cord-291950-9gtsqyfj	317	1	A	a	DT
cord-291950-9gtsqyfj	317	2	seventh	seventh	JJ
cord-291950-9gtsqyfj	317	3	subfamily	subfamily	NN
cord-291950-9gtsqyfj	317	4	,	,	,
cord-291950-9gtsqyfj	317	5	C3	C3	NNP
cord-291950-9gtsqyfj	317	6	G	g	NN
cord-291950-9gtsqyfj	317	7	,	,	,
cord-291950-9gtsqyfj	317	8	includes	include	VBZ
cord-291950-9gtsqyfj	317	9	a	a	DT
cord-291950-9gtsqyfj	317	10	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	317	11	processing	processing	NN
cord-291950-9gtsqyfj	317	12	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	317	13	from	from	IN
cord-291950-9gtsqyfj	317	14	rice	rice	NN
cord-291950-9gtsqyfj	317	15	tungro	tungro	NNP
cord-291950-9gtsqyfj	317	16	spherical	spherical	JJ
cord-291950-9gtsqyfj	317	17	virus	virus	NN
cord-291950-9gtsqyfj	317	18	.	.	.
cord-291950-9gtsqyfj	318	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	318	2	activity	activity	NN
cord-291950-9gtsqyfj	318	3	has	have	VBZ
cord-291950-9gtsqyfj	318	4	been	be	VBN
cord-291950-9gtsqyfj	318	5	demonstrated	demonstrate	VBN
cord-291950-9gtsqyfj	318	6	and	and	CC
cord-291950-9gtsqyfj	318	7	the	the	DT
cord-291950-9gtsqyfj	318	8	cleavage	cleavage	NN
cord-291950-9gtsqyfj	318	9	sites	site	NNS
cord-291950-9gtsqyfj	318	10	determined	determine	VBN
cord-291950-9gtsqyfj	318	11	by	by	IN
cord-291950-9gtsqyfj	318	12	site	site	NN
cord-291950-9gtsqyfj	318	13	directed	direct	VBN
cord-291950-9gtsqyfj	318	14	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	318	15	to	to	TO
cord-291950-9gtsqyfj	318	16	be	be	VB
cord-291950-9gtsqyfj	318	17	Gln2526kAsp	Gln2526kAsp	NNP
cord-291950-9gtsqyfj	318	18	and	and	CC
cord-291950-9gtsqyfj	318	19	Gln2852kAla	Gln2852kAla	NNS
cord-291950-9gtsqyfj	318	20	[	[	-LRB-
cord-291950-9gtsqyfj	318	21	48	48	CD
cord-291950-9gtsqyfj	318	22	]	]	-RRB-
cord-291950-9gtsqyfj	318	23	;	;	:
cord-291950-9gtsqyfj	318	24	the	the	DT
cord-291950-9gtsqyfj	318	25	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	318	26	residues	residue	NNS
cord-291950-9gtsqyfj	318	27	are	be	VBP
cord-291950-9gtsqyfj	318	28	predicted	predict	VBN
cord-291950-9gtsqyfj	318	29	to	to	TO
cord-291950-9gtsqyfj	318	30	be	be	VB
cord-291950-9gtsqyfj	318	31	His2680	His2680	NNP
cord-291950-9gtsqyfj	318	32	,	,	,
cord-291950-9gtsqyfj	318	33	Asp2722	Asp2722	NNP
cord-291950-9gtsqyfj	318	34	and	and	CC
cord-291950-9gtsqyfj	318	35	Cys2811	Cys2811	NNP
cord-291950-9gtsqyfj	318	36	(	(	-LRB-
cord-291950-9gtsqyfj	318	37	see	see	VB
cord-291950-9gtsqyfj	318	38	Alignment	Alignment	NNP
cord-291950-9gtsqyfj	318	39	C3	C3	NNP
cord-291950-9gtsqyfj	318	40	G	g	NN
cord-291950-9gtsqyfj	318	41	in	in	IN
cord-291950-9gtsqyfj	318	42	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	318	43	)	)	-RRB-
cord-291950-9gtsqyfj	318	44	.	.	.
cord-291950-9gtsqyfj	319	1	A	a	DT
cord-291950-9gtsqyfj	319	2	homolog	homolog	NN
cord-291950-9gtsqyfj	319	3	is	be	VBZ
cord-291950-9gtsqyfj	319	4	also	also	RB
cord-291950-9gtsqyfj	319	5	known	know	VBN
cord-291950-9gtsqyfj	319	6	from	from	IN
cord-291950-9gtsqyfj	319	7	maize	maize	NN
cord-291950-9gtsqyfj	319	8	chlorotic	chlorotic	JJ
cord-291950-9gtsqyfj	319	9	dwarf	dwarf	NN
cord-291950-9gtsqyfj	319	10	waikavirus	waikavirus	NNP
cord-291950-9gtsqyfj	319	11	.	.	.
cord-291950-9gtsqyfj	320	1	Family	family	NN
cord-291950-9gtsqyfj	320	2	C4	c4	NN
cord-291950-9gtsqyfj	320	3	contains	contain	VBZ
cord-291950-9gtsqyfj	320	4	one	one	CD
cord-291950-9gtsqyfj	320	5	of	of	IN
cord-291950-9gtsqyfj	320	6	the	the	DT
cord-291950-9gtsqyfj	320	7	three	three	CD
cord-291950-9gtsqyfj	320	8	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	320	9	processing	processing	NN
cord-291950-9gtsqyfj	320	10	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	320	11	from	from	IN
cord-291950-9gtsqyfj	320	12	potyviruses	potyviruses	NNP
cord-291950-9gtsqyfj	320	13	,	,	,
cord-291950-9gtsqyfj	320	14	which	which	WDT
cord-291950-9gtsqyfj	320	15	are	be	VBP
cord-291950-9gtsqyfj	320	16	plant	plant	NN
cord-291950-9gtsqyfj	320	17	pathogens	pathogen	NNS
cord-291950-9gtsqyfj	320	18	.	.	.
cord-291950-9gtsqyfj	321	1	The	the	DT
cord-291950-9gtsqyfj	321	2	NIa	nia	JJ
cord-291950-9gtsqyfj	321	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	321	4	has	have	VBZ
cord-291950-9gtsqyfj	321	5	been	be	VBN
cord-291950-9gtsqyfj	321	6	shown	show	VBN
cord-291950-9gtsqyfj	321	7	by	by	IN
cord-291950-9gtsqyfj	321	8	site	site	NN
cord-291950-9gtsqyfj	321	9	-	-	HYPH
cord-291950-9gtsqyfj	321	10	directed	direct	VBN
cord-291950-9gtsqyfj	321	11	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	321	12	to	to	TO
cord-291950-9gtsqyfj	321	13	have	have	VB
cord-291950-9gtsqyfj	321	14	at	at	IN
cord-291950-9gtsqyfj	321	15	least	least	JJS
cord-291950-9gtsqyfj	321	16	a	a	DT
cord-291950-9gtsqyfj	321	17	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	321	18	dyad	dyad	NN
cord-291950-9gtsqyfj	321	19	that	that	WDT
cord-291950-9gtsqyfj	321	20	is	be	VBZ
cord-291950-9gtsqyfj	321	21	in	in	IN
cord-291950-9gtsqyfj	321	22	the	the	DT
cord-291950-9gtsqyfj	321	23	order	order	NN
cord-291950-9gtsqyfj	321	24	His	-PRON-	PRP$
cord-291950-9gtsqyfj	321	25	,	,	,
cord-291950-9gtsqyfj	321	26	Cys	Cys	NNP
cord-291950-9gtsqyfj	321	27	[	[	-LRB-
cord-291950-9gtsqyfj	321	28	49	49	CD
cord-291950-9gtsqyfj	321	29	]	]	-RRB-
cord-291950-9gtsqyfj	321	30	.	.	.
cord-291950-9gtsqyfj	322	1	Another	another	DT
cord-291950-9gtsqyfj	322	2	similarity	similarity	NN
cord-291950-9gtsqyfj	322	3	with	with	IN
cord-291950-9gtsqyfj	322	4	family	family	NN
cord-291950-9gtsqyfj	322	5	C3	c3	NN
cord-291950-9gtsqyfj	322	6	is	be	VBZ
cord-291950-9gtsqyfj	322	7	the	the	DT
cord-291950-9gtsqyfj	322	8	preference	preference	NN
cord-291950-9gtsqyfj	322	9	for	for	IN
cord-291950-9gtsqyfj	322	10	cleavage	cleavage	NN
cord-291950-9gtsqyfj	322	11	of	of	IN
cord-291950-9gtsqyfj	322	12	GlnkGly	GlnkGly	NNP
cord-291950-9gtsqyfj	322	13	bonds	bond	NNS
cord-291950-9gtsqyfj	322	14	.	.	.
cord-291950-9gtsqyfj	323	1	The	the	DT
cord-291950-9gtsqyfj	323	2	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	323	3	is	be	VBZ
cord-291950-9gtsqyfj	323	4	a	a	DT
cord-291950-9gtsqyfj	323	5	multifunctional	multifunctional	JJ
cord-291950-9gtsqyfj	323	6	molecule	molecule	NN
cord-291950-9gtsqyfj	323	7	,	,	,
cord-291950-9gtsqyfj	323	8	acting	act	VBG
cord-291950-9gtsqyfj	323	9	also	also	RB
cord-291950-9gtsqyfj	323	10	as	as	IN
cord-291950-9gtsqyfj	323	11	the	the	DT
cord-291950-9gtsqyfj	323	12	Vpg	Vpg	NNP
cord-291950-9gtsqyfj	323	13	protein	protein	NN
cord-291950-9gtsqyfj	323	14	,	,	,
cord-291950-9gtsqyfj	323	15	which	which	WDT
cord-291950-9gtsqyfj	323	16	is	be	VBZ
cord-291950-9gtsqyfj	323	17	attached	attach	VBN
cord-291950-9gtsqyfj	323	18	covalently	covalently	RB
cord-291950-9gtsqyfj	323	19	to	to	IN
cord-291950-9gtsqyfj	323	20	the	the	DT
cord-291950-9gtsqyfj	323	21	viral	viral	JJ
cord-291950-9gtsqyfj	323	22	RNA	RNA	NNP
cord-291950-9gtsqyfj	323	23	[	[	-LRB-
cord-291950-9gtsqyfj	323	24	50	50	CD
cord-291950-9gtsqyfj	323	25	]	]	-RRB-
cord-291950-9gtsqyfj	323	26	.	.	.
cord-291950-9gtsqyfj	324	1	Family	Family	NNP
cord-291950-9gtsqyfj	324	2	C24	C24	NNP
cord-291950-9gtsqyfj	324	3	includes	include	VBZ
cord-291950-9gtsqyfj	324	4	the	the	DT
cord-291950-9gtsqyfj	324	5	processing	processing	NN
cord-291950-9gtsqyfj	324	6	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	324	7	from	from	IN
cord-291950-9gtsqyfj	324	8	caliciviruses	caliciviruse	NNS
cord-291950-9gtsqyfj	324	9	.	.	.
cord-291950-9gtsqyfj	325	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	325	2	residues	residue	NNS
cord-291950-9gtsqyfj	325	3	have	have	VBP
cord-291950-9gtsqyfj	325	4	been	be	VBN
cord-291950-9gtsqyfj	325	5	identified	identify	VBN
cord-291950-9gtsqyfj	325	6	in	in	IN
cord-291950-9gtsqyfj	325	7	the	the	DT
cord-291950-9gtsqyfj	325	8	rabbit	rabbit	NN
cord-291950-9gtsqyfj	325	9	hemorrhagic	hemorrhagic	JJ
cord-291950-9gtsqyfj	325	10	disease	disease	NN
cord-291950-9gtsqyfj	325	11	virus	virus	NN
cord-291950-9gtsqyfj	325	12	,	,	,
cord-291950-9gtsqyfj	325	13	and	and	CC
cord-291950-9gtsqyfj	325	14	a	a	DT
cord-291950-9gtsqyfj	325	15	His	-PRON-	PRP$
cord-291950-9gtsqyfj	325	16	,	,	,
cord-291950-9gtsqyfj	325	17	Cys	Cys	NNP
cord-291950-9gtsqyfj	325	18	dyad	dyad	NN
cord-291950-9gtsqyfj	325	19	is	be	VBZ
cord-291950-9gtsqyfj	325	20	the	the	DT
cord-291950-9gtsqyfj	325	21	most	most	RBS
cord-291950-9gtsqyfj	325	22	likely	likely	JJ
cord-291950-9gtsqyfj	325	23	order	order	NN
cord-291950-9gtsqyfj	325	24	in	in	IN
cord-291950-9gtsqyfj	325	25	the	the	DT
cord-291950-9gtsqyfj	325	26	sequence	sequence	NN
cord-291950-9gtsqyfj	325	27	,	,	,
cord-291950-9gtsqyfj	325	28	but	but	CC
cord-291950-9gtsqyfj	325	29	a	a	DT
cord-291950-9gtsqyfj	325	30	histidine	histidine	NN
cord-291950-9gtsqyfj	325	31	C	c	NN
cord-291950-9gtsqyfj	325	32	-	-	HYPH
cord-291950-9gtsqyfj	325	33	terminal	terminal	NN
cord-291950-9gtsqyfj	325	34	to	to	IN
cord-291950-9gtsqyfj	325	35	the	the	DT
cord-291950-9gtsqyfj	325	36	cysteine	cysteine	NN
cord-291950-9gtsqyfj	325	37	is	be	VBZ
cord-291950-9gtsqyfj	325	38	also	also	RB
cord-291950-9gtsqyfj	325	39	important	important	JJ
cord-291950-9gtsqyfj	325	40	,	,	,
cord-291950-9gtsqyfj	325	41	probably	probably	RB
cord-291950-9gtsqyfj	325	42	for	for	IN
cord-291950-9gtsqyfj	325	43	substrate	substrate	NN
cord-291950-9gtsqyfj	325	44	binding	bind	VBG
cord-291950-9gtsqyfj	325	45	[	[	-LRB-
cord-291950-9gtsqyfj	325	46	51	51	CD
cord-291950-9gtsqyfj	325	47	]	]	-RRB-
cord-291950-9gtsqyfj	325	48	.	.	.
cord-291950-9gtsqyfj	326	1	The	the	DT
cord-291950-9gtsqyfj	326	2	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	326	3	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	326	4	GlukGly	GlukGly	NNP
cord-291950-9gtsqyfj	326	5	bonds	bond	NNS
cord-291950-9gtsqyfj	326	6	in	in	IN
cord-291950-9gtsqyfj	326	7	the	the	DT
cord-291950-9gtsqyfj	326	8	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	326	9	[	[	-LRB-
cord-291950-9gtsqyfj	326	10	52	52	CD
cord-291950-9gtsqyfj	326	11	]	]	-RRB-
cord-291950-9gtsqyfj	326	12	.	.	.
cord-291950-9gtsqyfj	327	1	Family	family	NN
cord-291950-9gtsqyfj	327	2	C30	C30	NNP
cord-291950-9gtsqyfj	327	3	includes	include	VBZ
cord-291950-9gtsqyfj	327	4	the	the	DT
cord-291950-9gtsqyfj	327	5	processing	processing	NN
cord-291950-9gtsqyfj	327	6	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	327	7	from	from	IN
cord-291950-9gtsqyfj	327	8	coronaviruses	coronaviruse	NNS
cord-291950-9gtsqyfj	327	9	.	.	.
cord-291950-9gtsqyfj	328	1	Again	again	RB
cord-291950-9gtsqyfj	328	2	,	,	,
cord-291950-9gtsqyfj	328	3	there	there	EX
cord-291950-9gtsqyfj	328	4	is	be	VBZ
cord-291950-9gtsqyfj	328	5	a	a	DT
cord-291950-9gtsqyfj	328	6	His	His	NNP
cord-291950-9gtsqyfj	328	7	,	,	,
cord-291950-9gtsqyfj	328	8	Cys	Cys	NNP
cord-291950-9gtsqyfj	328	9	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	328	10	dyad	dyad	NN
cord-291950-9gtsqyfj	328	11	,	,	,
cord-291950-9gtsqyfj	328	12	and	and	CC
cord-291950-9gtsqyfj	328	13	cleavage	cleavage	NN
cord-291950-9gtsqyfj	328	14	is	be	VBZ
cord-291950-9gtsqyfj	328	15	preferentially	preferentially	RB
cord-291950-9gtsqyfj	328	16	at	at	IN
cord-291950-9gtsqyfj	328	17	GlnkGly	GlnkGly	NNP
cord-291950-9gtsqyfj	328	18	bonds	bond	NNS
cord-291950-9gtsqyfj	328	19	[	[	-LRB-
cord-291950-9gtsqyfj	328	20	53	53	CD
cord-291950-9gtsqyfj	328	21	]	]	-RRB-
cord-291950-9gtsqyfj	328	22	.	.	.
cord-291950-9gtsqyfj	329	1	A	a	DT
cord-291950-9gtsqyfj	329	2	representation	representation	NN
cord-291950-9gtsqyfj	329	3	of	of	IN
cord-291950-9gtsqyfj	329	4	the	the	DT
cord-291950-9gtsqyfj	329	5	three	three	CD
cord-291950-9gtsqyfj	329	6	-	-	HYPH
cord-291950-9gtsqyfj	329	7	dimensional	dimensional	JJ
cord-291950-9gtsqyfj	329	8	structure	structure	NN
cord-291950-9gtsqyfj	329	9	of	of	IN
cord-291950-9gtsqyfj	329	10	the	the	DT
cord-291950-9gtsqyfj	329	11	processing	processing	NN
cord-291950-9gtsqyfj	329	12	peptidase	peptidase	NN
cord-291950-9gtsqyfj	329	13	from	from	IN
cord-291950-9gtsqyfj	329	14	porcine	porcine	JJ
cord-291950-9gtsqyfj	329	15	transmissible	transmissible	JJ
cord-291950-9gtsqyfj	329	16	gastroenteritis	gastroenteritis	NN
cord-291950-9gtsqyfj	329	17	virus	virus	NN
cord-291950-9gtsqyfj	330	1	main	main	JJ
cord-291950-9gtsqyfj	330	2	protease	protease	NN
cord-291950-9gtsqyfj	330	3	is	be	VBZ
cord-291950-9gtsqyfj	330	4	shown	show	VBN
cord-291950-9gtsqyfj	330	5	in	in	IN
cord-291950-9gtsqyfj	330	6	Figure	figure	NN
cord-291950-9gtsqyfj	330	7	404	404	CD
cord-291950-9gtsqyfj	330	8	.	.	.
cord-291950-9gtsqyfj	331	1	21	21	CD
cord-291950-9gtsqyfj	331	2	.	.	.
cord-291950-9gtsqyfj	332	1	Family	Family	NNP
cord-291950-9gtsqyfj	332	2	C37	C37	NNP
cord-291950-9gtsqyfj	332	3	contains	contain	VBZ
cord-291950-9gtsqyfj	332	4	the	the	DT
cord-291950-9gtsqyfj	332	5	processing	processing	NN
cord-291950-9gtsqyfj	332	6	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	332	7	of	of	IN
cord-291950-9gtsqyfj	332	8	Southampton	Southampton	NNP
cord-291950-9gtsqyfj	332	9	and	and	CC
cord-291950-9gtsqyfj	332	10	Norwalk	Norwalk	NNP
cord-291950-9gtsqyfj	332	11	caliciviruses	caliciviruse	NNS
cord-291950-9gtsqyfj	332	12	.	.	.
cord-291950-9gtsqyfj	333	1	The	the	DT
cord-291950-9gtsqyfj	333	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	333	3	cysteine	cysteine	NN
cord-291950-9gtsqyfj	333	4	has	have	VBZ
cord-291950-9gtsqyfj	333	5	been	be	VBN
cord-291950-9gtsqyfj	333	6	identified	identify	VBN
cord-291950-9gtsqyfj	333	7	in	in	IN
cord-291950-9gtsqyfj	333	8	Southampton	Southampton	NNP
cord-291950-9gtsqyfj	333	9	virus	virus	NN
cord-291950-9gtsqyfj	333	10	,	,	,
cord-291950-9gtsqyfj	333	11	and	and	CC
cord-291950-9gtsqyfj	333	12	there	there	EX
cord-291950-9gtsqyfj	333	13	is	be	VBZ
cord-291950-9gtsqyfj	333	14	a	a	DT
cord-291950-9gtsqyfj	333	15	preference	preference	NN
cord-291950-9gtsqyfj	333	16	for	for	IN
cord-291950-9gtsqyfj	333	17	cleavage	cleavage	NN
cord-291950-9gtsqyfj	333	18	at	at	IN
cord-291950-9gtsqyfj	333	19	GlnkGly	GlnkGly	NNP
cord-291950-9gtsqyfj	333	20	bonds	bond	NNS
cord-291950-9gtsqyfj	333	21	[	[	-LRB-
cord-291950-9gtsqyfj	333	22	54	54	CD
cord-291950-9gtsqyfj	333	23	]	]	-RRB-
cord-291950-9gtsqyfj	333	24	.	.	.
cord-291950-9gtsqyfj	334	1	Family	Family	NNP
cord-291950-9gtsqyfj	334	2	C38	C38	NNP
cord-291950-9gtsqyfj	334	3	comprises	comprise	VBZ
cord-291950-9gtsqyfj	334	4	a	a	DT
cord-291950-9gtsqyfj	334	5	putative	putative	JJ
cord-291950-9gtsqyfj	334	6	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	334	7	from	from	IN
cord-291950-9gtsqyfj	334	8	parsnip	parsnip	NNP
cord-291950-9gtsqyfj	334	9	yellow	yellow	NNP
cord-291950-9gtsqyfj	334	10	fleck	fleck	NNP
cord-291950-9gtsqyfj	334	11	virus	virus	NN
cord-291950-9gtsqyfj	334	12	identified	identify	VBN
cord-291950-9gtsqyfj	334	13	by	by	IN
cord-291950-9gtsqyfj	334	14	comparison	comparison	NN
cord-291950-9gtsqyfj	334	15	with	with	IN
cord-291950-9gtsqyfj	334	16	the	the	DT
cord-291950-9gtsqyfj	334	17	picornavirus	picornavirus	NNP
cord-291950-9gtsqyfj	334	18	polyprotein	polyprotein	NNP
cord-291950-9gtsqyfj	334	19	[	[	-LRB-
cord-291950-9gtsqyfj	334	20	55	55	CD
cord-291950-9gtsqyfj	334	21	]	]	-RRB-
cord-291950-9gtsqyfj	334	22	.	.	.
cord-291950-9gtsqyfj	335	1	Family	Family	NNP
cord-291950-9gtsqyfj	335	2	C74	C74	NNP
cord-291950-9gtsqyfj	335	3	includes	include	VBZ
cord-291950-9gtsqyfj	335	4	the	the	DT
cord-291950-9gtsqyfj	335	5	NS2	NS2	NNP
cord-291950-9gtsqyfj	335	6	protein	protein	NN
cord-291950-9gtsqyfj	335	7	,	,	,
cord-291950-9gtsqyfj	335	8	one	one	CD
cord-291950-9gtsqyfj	335	9	of	of	IN
cord-291950-9gtsqyfj	335	10	the	the	DT
cord-291950-9gtsqyfj	335	11	three	three	CD
cord-291950-9gtsqyfj	335	12	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	335	13	processing	processing	NN
cord-291950-9gtsqyfj	335	14	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	335	15	from	from	IN
cord-291950-9gtsqyfj	335	16	pestiviruses	pestiviruse	NNS
cord-291950-9gtsqyfj	335	17	.	.	.
cord-291950-9gtsqyfj	336	1	The	the	DT
cord-291950-9gtsqyfj	336	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	336	3	triad	triad	NN
cord-291950-9gtsqyfj	336	4	has	have	VBZ
cord-291950-9gtsqyfj	336	5	been	be	VBN
cord-291950-9gtsqyfj	336	6	established	establish	VBN
cord-291950-9gtsqyfj	336	7	by	by	IN
cord-291950-9gtsqyfj	336	8	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	336	9	as	as	IN
cord-291950-9gtsqyfj	336	10	His	-PRON-	PRP$
cord-291950-9gtsqyfj	336	11	,	,	,
cord-291950-9gtsqyfj	336	12	Glu	Glu	NNP
cord-291950-9gtsqyfj	336	13	,	,	,
cord-291950-9gtsqyfj	336	14	Cys	Cys	NNP
cord-291950-9gtsqyfj	336	15	,	,	,
cord-291950-9gtsqyfj	336	16	consistent	consistent	JJ
cord-291950-9gtsqyfj	336	17	with	with	IN
cord-291950-9gtsqyfj	336	18	other	other	JJ
cord-291950-9gtsqyfj	336	19	families	family	NNS
cord-291950-9gtsqyfj	336	20	in	in	IN
cord-291950-9gtsqyfj	336	21	subclan	subclan	NNP
cord-291950-9gtsqyfj	336	22	PA(C	pa(c	CD
cord-291950-9gtsqyfj	336	23	)	)	-RRB-
cord-291950-9gtsqyfj	337	1	[	[	-LRB-
cord-291950-9gtsqyfj	337	2	56	56	CD
cord-291950-9gtsqyfj	337	3	]	]	-RRB-
cord-291950-9gtsqyfj	337	4	.	.	.
cord-291950-9gtsqyfj	338	1	Clan	Clan	NNP
cord-291950-9gtsqyfj	338	2	CD	CD	NNP
cord-291950-9gtsqyfj	338	3	contains	contain	VBZ
cord-291950-9gtsqyfj	338	4	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	338	5	in	in	IN
cord-291950-9gtsqyfj	338	6	which	which	WDT
cord-291950-9gtsqyfj	338	7	only	only	RB
cord-291950-9gtsqyfj	338	8	a	a	DT
cord-291950-9gtsqyfj	338	9	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	338	10	dyad	dyad	NN
cord-291950-9gtsqyfj	338	11	appears	appear	VBZ
cord-291950-9gtsqyfj	338	12	to	to	TO
cord-291950-9gtsqyfj	338	13	exist	exist	VB
cord-291950-9gtsqyfj	338	14	,	,	,
cord-291950-9gtsqyfj	338	15	in	in	IN
cord-291950-9gtsqyfj	338	16	the	the	DT
cord-291950-9gtsqyfj	338	17	order	order	NN
cord-291950-9gtsqyfj	338	18	His	-PRON-	PRP$
cord-291950-9gtsqyfj	338	19	,	,	,
cord-291950-9gtsqyfj	338	20	Cys	Cys	NNP
cord-291950-9gtsqyfj	338	21	in	in	IN
cord-291950-9gtsqyfj	338	22	the	the	DT
cord-291950-9gtsqyfj	338	23	sequence	sequence	NN
cord-291950-9gtsqyfj	338	24	.	.	.
cord-291950-9gtsqyfj	339	1	Chen	Chen	NNP
cord-291950-9gtsqyfj	339	2	et	et	NNP
cord-291950-9gtsqyfj	339	3	al	al	NNP
cord-291950-9gtsqyfj	339	4	.	.	.
cord-291950-9gtsqyfj	340	1	[	[	-LRB-
cord-291950-9gtsqyfj	340	2	57	57	CD
cord-291950-9gtsqyfj	340	3	]	]	-RRB-
cord-291950-9gtsqyfj	340	4	recognized	recognize	VBN
cord-291950-9gtsqyfj	340	5	that	that	DT
cord-291950-9gtsqyfj	340	6	sequence	sequence	NN
cord-291950-9gtsqyfj	340	7	motifs	motif	NNS
cord-291950-9gtsqyfj	340	8	around	around	IN
cord-291950-9gtsqyfj	340	9	the	the	DT
cord-291950-9gtsqyfj	340	10	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	340	11	residues	residue	NNS
cord-291950-9gtsqyfj	340	12	in	in	IN
cord-291950-9gtsqyfj	340	13	mammalian	mammalian	JJ
cord-291950-9gtsqyfj	340	14	legumain	legumain	NN
cord-291950-9gtsqyfj	340	15	were	be	VBD
cord-291950-9gtsqyfj	340	16	similar	similar	JJ
cord-291950-9gtsqyfj	340	17	to	to	IN
cord-291950-9gtsqyfj	340	18	those	those	DT
cord-291950-9gtsqyfj	340	19	in	in	IN
cord-291950-9gtsqyfj	340	20	the	the	DT
cord-291950-9gtsqyfj	340	21	caspases	caspase	NNS
cord-291950-9gtsqyfj	340	22	(	(	-LRB-
cord-291950-9gtsqyfj	340	23	family	family	NN
cord-291950-9gtsqyfj	340	24	C14	C14	NNP
cord-291950-9gtsqyfj	340	25	)	)	-RRB-
cord-291950-9gtsqyfj	340	26	.	.	.
cord-291950-9gtsqyfj	341	1	Moreover	moreover	RB
cord-291950-9gtsqyfj	341	2	,	,	,
cord-291950-9gtsqyfj	341	3	they	-PRON-	PRP
cord-291950-9gtsqyfj	341	4	saw	see	VBD
cord-291950-9gtsqyfj	341	5	similar	similar	JJ
cord-291950-9gtsqyfj	341	6	motifs	motif	NNS
cord-291950-9gtsqyfj	341	7	in	in	IN
cord-291950-9gtsqyfj	341	8	the	the	DT
cord-291950-9gtsqyfj	341	9	cysteine	cysteine	NN
cord-291950-9gtsqyfj	341	10	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	341	11	of	of	IN
cord-291950-9gtsqyfj	341	12	families	family	NNS
cord-291950-9gtsqyfj	341	13	C11	C11	NNP
cord-291950-9gtsqyfj	341	14	(	(	-LRB-
cord-291950-9gtsqyfj	341	15	clostripain	clostripain	NNP
cord-291950-9gtsqyfj	341	16	)	)	-RRB-
cord-291950-9gtsqyfj	341	17	and	and	CC
cord-291950-9gtsqyfj	341	18	C25	C25	NNP
cord-291950-9gtsqyfj	341	19	(	(	-LRB-
cord-291950-9gtsqyfj	341	20	gingipain	gingipain	NNP
cord-291950-9gtsqyfj	341	21	R	R	NNP
cord-291950-9gtsqyfj	341	22	)	)	-RRB-
cord-291950-9gtsqyfj	341	23	.	.	.
cord-291950-9gtsqyfj	342	1	They	-PRON-	PRP
cord-291950-9gtsqyfj	342	2	proposed	propose	VBD
cord-291950-9gtsqyfj	342	3	the	the	DT
cord-291950-9gtsqyfj	342	4	existence	existence	NN
cord-291950-9gtsqyfj	342	5	of	of	IN
cord-291950-9gtsqyfj	342	6	a	a	DT
cord-291950-9gtsqyfj	342	7	clan	clan	NN
cord-291950-9gtsqyfj	342	8	CD	cd	NN
cord-291950-9gtsqyfj	342	9	of	of	IN
cord-291950-9gtsqyfj	342	10	cysteine	cysteine	NN
cord-291950-9gtsqyfj	342	11	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	342	12	with	with	IN
cord-291950-9gtsqyfj	342	13	a	a	DT
cord-291950-9gtsqyfj	342	14	protein	protein	NN
cord-291950-9gtsqyfj	342	15	fold	fold	VBP
cord-291950-9gtsqyfj	342	16	similar	similar	JJ
cord-291950-9gtsqyfj	342	17	to	to	IN
cord-291950-9gtsqyfj	342	18	that	that	DT
cord-291950-9gtsqyfj	342	19	already	already	RB
cord-291950-9gtsqyfj	342	20	known	know	VBN
cord-291950-9gtsqyfj	342	21	for	for	IN
cord-291950-9gtsqyfj	342	22	the	the	DT
cord-291950-9gtsqyfj	342	23	caspases	caspase	NNS
cord-291950-9gtsqyfj	342	24	(	(	-LRB-
cord-291950-9gtsqyfj	342	25	family	family	NN
cord-291950-9gtsqyfj	342	26	C14	C14	NNP
cord-291950-9gtsqyfj	342	27	)	)	-RRB-
cord-291950-9gtsqyfj	342	28	.	.	.
cord-291950-9gtsqyfj	343	1	The	the	DT
cord-291950-9gtsqyfj	343	2	proposal	proposal	NN
cord-291950-9gtsqyfj	343	3	soon	soon	RB
cord-291950-9gtsqyfj	343	4	received	receive	VBD
cord-291950-9gtsqyfj	343	5	support	support	NN
cord-291950-9gtsqyfj	343	6	from	from	IN
cord-291950-9gtsqyfj	343	7	the	the	DT
cord-291950-9gtsqyfj	343	8	crystal	crystal	JJ
cord-291950-9gtsqyfj	343	9	structure	structure	NN
cord-291950-9gtsqyfj	343	10	of	of	IN
cord-291950-9gtsqyfj	343	11	gingipain	gingipain	NNP
cord-291950-9gtsqyfj	343	12	R2	R2	NNP
cord-291950-9gtsqyfj	343	13	.	.	.
cord-291950-9gtsqyfj	344	1	The	the	DT
cord-291950-9gtsqyfj	344	2	structure	structure	NN
cord-291950-9gtsqyfj	344	3	of	of	IN
cord-291950-9gtsqyfj	344	4	caspase	caspase	NN
cord-291950-9gtsqyfj	344	5	1	1	CD
cord-291950-9gtsqyfj	344	6	(	(	-LRB-
cord-291950-9gtsqyfj	344	7	see	see	VB
cord-291950-9gtsqyfj	344	8	Figure	Figure	NNP
cord-291950-9gtsqyfj	344	9	404	404	CD
cord-291950-9gtsqyfj	344	10	.22	.22	CD
cord-291950-9gtsqyfj	344	11	,	,	,
cord-291950-9gtsqyfj	344	12	Chapter	chapter	NN
cord-291950-9gtsqyfj	344	13	503	503	CD
cord-291950-9gtsqyfj	344	14	)	)	-RRB-
cord-291950-9gtsqyfj	344	15	shows	show	VBZ
cord-291950-9gtsqyfj	344	16	a	a	DT
cord-291950-9gtsqyfj	344	17	distinctive	distinctive	JJ
cord-291950-9gtsqyfj	344	18	α	α	NN
cord-291950-9gtsqyfj	344	19	/	/	SYM
cord-291950-9gtsqyfj	344	20	β	β	NN
cord-291950-9gtsqyfj	344	21	fold	fold	VB
cord-291950-9gtsqyfj	344	22	quite	quite	RB
cord-291950-9gtsqyfj	344	23	unlike	unlike	IN
cord-291950-9gtsqyfj	344	24	those	those	DT
cord-291950-9gtsqyfj	344	25	of	of	IN
cord-291950-9gtsqyfj	344	26	clans	clan	NNS
cord-291950-9gtsqyfj	344	27	CA	CA	NNP
cord-291950-9gtsqyfj	344	28	and	and	CC
cord-291950-9gtsqyfj	344	29	PA	PA	NNP
cord-291950-9gtsqyfj	344	30	.	.	.
cord-291950-9gtsqyfj	345	1	In	in	IN
cord-291950-9gtsqyfj	345	2	the	the	DT
cord-291950-9gtsqyfj	345	3	sequence	sequence	NN
cord-291950-9gtsqyfj	345	4	motif	motif	NN
cord-291950-9gtsqyfj	345	5	described	describe	VBN
cord-291950-9gtsqyfj	345	6	by	by	IN
cord-291950-9gtsqyfj	345	7	Chen	Chen	NNP
cord-291950-9gtsqyfj	345	8	et	et	NNP
cord-291950-9gtsqyfj	345	9	al	al	NNP
cord-291950-9gtsqyfj	345	10	.	.	.
cord-291950-9gtsqyfj	346	1	[	[	-LRB-
cord-291950-9gtsqyfj	346	2	57	57	CD
cord-291950-9gtsqyfj	346	3	]	]	-RRB-
cord-291950-9gtsqyfj	346	4	,	,	,
cord-291950-9gtsqyfj	346	5	the	the	DT
cord-291950-9gtsqyfj	346	6	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	346	7	histidine	histidine	NN
cord-291950-9gtsqyfj	346	8	is	be	VBZ
cord-291950-9gtsqyfj	346	9	preceded	precede	VBN
cord-291950-9gtsqyfj	346	10	by	by	IN
cord-291950-9gtsqyfj	346	11	a	a	DT
cord-291950-9gtsqyfj	346	12	block	block	NN
cord-291950-9gtsqyfj	346	13	of	of	IN
cord-291950-9gtsqyfj	346	14	hydrophobic	hydrophobic	JJ
cord-291950-9gtsqyfj	346	15	residues	residue	NNS
cord-291950-9gtsqyfj	346	16	and	and	CC
cord-291950-9gtsqyfj	346	17	a	a	DT
cord-291950-9gtsqyfj	346	18	glycine	glycine	NN
cord-291950-9gtsqyfj	346	19	,	,	,
cord-291950-9gtsqyfj	346	20	and	and	CC
cord-291950-9gtsqyfj	346	21	the	the	DT
cord-291950-9gtsqyfj	346	22	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	346	23	cysteine	cysteine	NN
cord-291950-9gtsqyfj	346	24	is	be	VBZ
cord-291950-9gtsqyfj	346	25	preceded	precede	VBN
cord-291950-9gtsqyfj	346	26	by	by	IN
cord-291950-9gtsqyfj	346	27	a	a	DT
cord-291950-9gtsqyfj	346	28	second	second	JJ
cord-291950-9gtsqyfj	346	29	block	block	NN
cord-291950-9gtsqyfj	346	30	of	of	IN
cord-291950-9gtsqyfj	346	31	hydrophobic	hydrophobic	JJ
cord-291950-9gtsqyfj	346	32	residues	residue	NNS
cord-291950-9gtsqyfj	346	33	,	,	,
cord-291950-9gtsqyfj	346	34	a	a	DT
cord-291950-9gtsqyfj	346	35	glutamine	glutamine	NN
cord-291950-9gtsqyfj	346	36	and	and	CC
cord-291950-9gtsqyfj	346	37	an	an	DT
cord-291950-9gtsqyfj	346	38	alanine	alanine	NN
cord-291950-9gtsqyfj	346	39	(	(	-LRB-
cord-291950-9gtsqyfj	346	40	see	see	VB
cord-291950-9gtsqyfj	346	41	Figures	figure	NNS
cord-291950-9gtsqyfj	346	42	404.23	404.23	CD
cord-291950-9gtsqyfj	346	43	and	and	CC
cord-291950-9gtsqyfj	346	44	404.24	404.24	CD
cord-291950-9gtsqyfj	346	45	.	.	.
cord-291950-9gtsqyfj	347	1	A	a	DT
cord-291950-9gtsqyfj	347	2	similar	similar	JJ
cord-291950-9gtsqyfj	347	3	motif	motif	NN
cord-291950-9gtsqyfj	347	4	has	have	VBZ
cord-291950-9gtsqyfj	347	5	been	be	VBN
cord-291950-9gtsqyfj	347	6	recognized	recognize	VBN
cord-291950-9gtsqyfj	347	7	in	in	IN
cord-291950-9gtsqyfj	347	8	separase	separase	NNP
cord-291950-9gtsqyfj	347	9	(	(	-LRB-
cord-291950-9gtsqyfj	347	10	family	family	NN
cord-291950-9gtsqyfj	347	11	C50	C50	NNP
cord-291950-9gtsqyfj	347	12	)	)	-RRB-
cord-291950-9gtsqyfj	347	13	,	,	,
cord-291950-9gtsqyfj	347	14	RTX	RTX	NNP
cord-291950-9gtsqyfj	347	15	selfcleaving	selfcleave	VBG
cord-291950-9gtsqyfj	347	16	toxin(family	toxin(family	RB
cord-291950-9gtsqyfj	347	17	C80	C80	NNP
cord-291950-9gtsqyfj	347	18	)	)	-RRB-
cord-291950-9gtsqyfj	347	19	and	and	CC
cord-291950-9gtsqyfj	347	20	prtH	prth	CD
cord-291950-9gtsqyfj	347	21	peptidase	peptidase	NN
cord-291950-9gtsqyfj	347	22	(	(	-LRB-
cord-291950-9gtsqyfj	347	23	family	family	NN
cord-291950-9gtsqyfj	347	24	C84	C84	NNP
cord-291950-9gtsqyfj	347	25	)	)	-RRB-
cord-291950-9gtsqyfj	347	26	,	,	,
cord-291950-9gtsqyfj	347	27	and	and	CC
cord-291950-9gtsqyfj	347	28	all	all	DT
cord-291950-9gtsqyfj	347	29	three	three	CD
cord-291950-9gtsqyfj	347	30	families	family	NNS
cord-291950-9gtsqyfj	347	31	have	have	VBP
cord-291950-9gtsqyfj	347	32	been	be	VBN
cord-291950-9gtsqyfj	347	33	added	add	VBN
cord-291950-9gtsqyfj	347	34	to	to	IN
cord-291950-9gtsqyfj	347	35	clan	clan	NN
cord-291950-9gtsqyfj	347	36	CD	CD	NNP
cord-291950-9gtsqyfj	347	37	.	.	.
cord-291950-9gtsqyfj	348	1	Similar	similar	JJ
cord-291950-9gtsqyfj	348	2	motifs	motif	NNS
cord-291950-9gtsqyfj	348	3	are	be	VBP
cord-291950-9gtsqyfj	348	4	present	present	JJ
cord-291950-9gtsqyfj	348	5	in	in	IN
cord-291950-9gtsqyfj	348	6	proteins	protein	NNS
cord-291950-9gtsqyfj	348	7	not	not	RB
cord-291950-9gtsqyfj	348	8	yet	yet	RB
cord-291950-9gtsqyfj	348	9	known	know	VBN
cord-291950-9gtsqyfj	348	10	to	to	TO
cord-291950-9gtsqyfj	348	11	be	be	VB
cord-291950-9gtsqyfj	348	12	peptidases	peptidases	NNP
cord-291950-9gtsqyfj	348	13	[	[	-LRB-
cord-291950-9gtsqyfj	348	14	58	58	CD
cord-291950-9gtsqyfj	348	15	]	]	-RRB-
cord-291950-9gtsqyfj	349	1	so	so	IN
cord-291950-9gtsqyfj	349	2	the	the	DT
cord-291950-9gtsqyfj	349	3	clan	clan	NN
cord-291950-9gtsqyfj	349	4	may	may	MD
cord-291950-9gtsqyfj	349	5	expand	expand	VB
cord-291950-9gtsqyfj	349	6	still	still	RB
cord-291950-9gtsqyfj	349	7	further	further	RB
cord-291950-9gtsqyfj	349	8	.	.	.
cord-291950-9gtsqyfj	350	1	The	the	DT
cord-291950-9gtsqyfj	350	2	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	350	3	in	in	IN
cord-291950-9gtsqyfj	350	4	clan	clan	NN
cord-291950-9gtsqyfj	350	5	CD	CD	NNP
cord-291950-9gtsqyfj	350	6	have	have	VBP
cord-291950-9gtsqyfj	350	7	some	some	DT
cord-291950-9gtsqyfj	350	8	biochemical	biochemical	JJ
cord-291950-9gtsqyfj	350	9	similarities	similarity	NNS
cord-291950-9gtsqyfj	350	10	.	.	.
cord-291950-9gtsqyfj	351	1	They	-PRON-	PRP
cord-291950-9gtsqyfj	351	2	are	be	VBP
cord-291950-9gtsqyfj	351	3	all	all	RB
cord-291950-9gtsqyfj	351	4	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	351	5	with	with	IN
cord-291950-9gtsqyfj	351	6	restricted	restrict	VBN
cord-291950-9gtsqyfj	351	7	specificity	specificity	NN
cord-291950-9gtsqyfj	351	8	dominated	dominate	VBN
cord-291950-9gtsqyfj	351	9	by	by	IN
cord-291950-9gtsqyfj	351	10	selectivity	selectivity	NN
cord-291950-9gtsqyfj	351	11	for	for	IN
cord-291950-9gtsqyfj	351	12	the	the	DT
cord-291950-9gtsqyfj	351	13	P1	P1	NNP
cord-291950-9gtsqyfj	351	14	residue	residue	NN
cord-291950-9gtsqyfj	351	15	of	of	IN
cord-291950-9gtsqyfj	351	16	the	the	DT
cord-291950-9gtsqyfj	351	17	substrate	substrate	NN
cord-291950-9gtsqyfj	351	18	.	.	.
cord-291950-9gtsqyfj	352	1	Thus	thus	RB
cord-291950-9gtsqyfj	352	2	,	,	,
cord-291950-9gtsqyfj	352	3	in	in	IN
cord-291950-9gtsqyfj	352	4	family	family	NN
cord-291950-9gtsqyfj	352	5	C14	C14	NNP
cord-291950-9gtsqyfj	352	6	cleavage	cleavage	NN
cord-291950-9gtsqyfj	352	7	occurs	occur	VBZ
cord-291950-9gtsqyfj	352	8	predominately	predominately	RB
cord-291950-9gtsqyfj	352	9	after	after	IN
cord-291950-9gtsqyfj	352	10	Asp	Asp	NNP
cord-291950-9gtsqyfj	352	11	,	,	,
cord-291950-9gtsqyfj	352	12	in	in	IN
cord-291950-9gtsqyfj	352	13	C13	C13	NNP
cord-291950-9gtsqyfj	352	14	after	after	IN
cord-291950-9gtsqyfj	352	15	Asn	Asn	NNP
cord-291950-9gtsqyfj	352	16	,	,	,
cord-291950-9gtsqyfj	352	17	in	in	IN
cord-291950-9gtsqyfj	352	18	C11	C11	NNP
cord-291950-9gtsqyfj	352	19	and	and	CC
cord-291950-9gtsqyfj	352	20	C50	C50	NNP
cord-291950-9gtsqyfj	352	21	after	after	IN
cord-291950-9gtsqyfj	352	22	Arg	Arg	NNP
cord-291950-9gtsqyfj	352	23	,	,	,
cord-291950-9gtsqyfj	352	24	and	and	CC
cord-291950-9gtsqyfj	352	25	in	in	IN
cord-291950-9gtsqyfj	352	26	C25	C25	NNP
cord-291950-9gtsqyfj	352	27	after	after	IN
cord-291950-9gtsqyfj	352	28	Arg	Arg	NNP
cord-291950-9gtsqyfj	352	29	or	or	CC
cord-291950-9gtsqyfj	352	30	Lys	Lys	NNP
cord-291950-9gtsqyfj	352	31	depending	depend	VBG
cord-291950-9gtsqyfj	352	32	on	on	IN
cord-291950-9gtsqyfj	352	33	the	the	DT
cord-291950-9gtsqyfj	352	34	peptidase	peptidase	NN
cord-291950-9gtsqyfj	352	35	.	.	.
cord-291950-9gtsqyfj	353	1	This	this	DT
cord-291950-9gtsqyfj	353	2	P1-dominated	p1-dominate	VBN
cord-291950-9gtsqyfj	353	3	type	type	NN
cord-291950-9gtsqyfj	353	4	of	of	IN
cord-291950-9gtsqyfj	353	5	specificity	specificity	NN
cord-291950-9gtsqyfj	353	6	resembles	resemble	VBZ
cord-291950-9gtsqyfj	353	7	that	that	DT
cord-291950-9gtsqyfj	353	8	of	of	IN
cord-291950-9gtsqyfj	353	9	the	the	DT
cord-291950-9gtsqyfj	353	10	unrelated	unrelated	JJ
cord-291950-9gtsqyfj	353	11	chymotrypsin	chymotrypsin	JJ
cord-291950-9gtsqyfj	353	12	-	-	HYPH
cord-291950-9gtsqyfj	353	13	like	like	JJ
cord-291950-9gtsqyfj	353	14	serine	serine	NN
cord-291950-9gtsqyfj	353	15	peptidases	peptidases	NNPS
cord-291950-9gtsqyfj	353	16	in	in	IN
cord-291950-9gtsqyfj	353	17	subclanclan	subclanclan	NNP
cord-291950-9gtsqyfj	353	18	PA(S	PA(S	NNP
cord-291950-9gtsqyfj	353	19	)	)	-RRB-
cord-291950-9gtsqyfj	353	20	,	,	,
cord-291950-9gtsqyfj	353	21	and	and	CC
cord-291950-9gtsqyfj	353	22	is	be	VBZ
cord-291950-9gtsqyfj	353	23	quite	quite	RB
cord-291950-9gtsqyfj	353	24	unlike	unlike	IN
cord-291950-9gtsqyfj	353	25	clan	clan	NN
cord-291950-9gtsqyfj	353	26	CA	CA	NNP
cord-291950-9gtsqyfj	353	27	.	.	.
cord-291950-9gtsqyfj	354	1	The	the	DT
cord-291950-9gtsqyfj	354	2	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	354	3	in	in	IN
cord-291950-9gtsqyfj	354	4	the	the	DT
cord-291950-9gtsqyfj	354	5	clan	clan	NN
cord-291950-9gtsqyfj	354	6	are	be	VBP
cord-291950-9gtsqyfj	354	7	not	not	RB
cord-291950-9gtsqyfj	354	8	irreversibly	irreversibly	RB
cord-291950-9gtsqyfj	354	9	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	354	10	by	by	IN
cord-291950-9gtsqyfj	354	11	E-64	E-64	NNP
cord-291950-9gtsqyfj	354	12	,	,	,
cord-291950-9gtsqyfj	354	13	in	in	IN
cord-291950-9gtsqyfj	354	14	contrast	contrast	NN
cord-291950-9gtsqyfj	354	15	to	to	IN
cord-291950-9gtsqyfj	354	16	most	most	JJS
cord-291950-9gtsqyfj	354	17	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	354	18	in	in	IN
cord-291950-9gtsqyfj	354	19	clan	clan	NN
cord-291950-9gtsqyfj	354	20	CA	CA	NNP
cord-291950-9gtsqyfj	354	21	.	.	.
cord-291950-9gtsqyfj	355	1	Clostripain	Clostripain	NNP
cord-291950-9gtsqyfj	355	2	and	and	CC
cord-291950-9gtsqyfj	355	3	legumain	legumain	NN
cord-291950-9gtsqyfj	355	4	react	react	VBP
cord-291950-9gtsqyfj	355	5	more	more	RBR
cord-291950-9gtsqyfj	355	6	rapidly	rapidly	RB
cord-291950-9gtsqyfj	355	7	with	with	IN
cord-291950-9gtsqyfj	355	8	iodoacetamide	iodoacetamide	NN
cord-291950-9gtsqyfj	355	9	than	than	IN
cord-291950-9gtsqyfj	355	10	with	with	IN
cord-291950-9gtsqyfj	355	11	iodoacetate	iodoacetate	NNP
cord-291950-9gtsqyfj	355	12	,	,	,
cord-291950-9gtsqyfj	355	13	whereas	whereas	IN
cord-291950-9gtsqyfj	355	14	iodoacetate	iodoacetate	NNP
cord-291950-9gtsqyfj	355	15	is	be	VBZ
cord-291950-9gtsqyfj	355	16	the	the	DT
cord-291950-9gtsqyfj	355	17	faster	fast	JJR
cord-291950-9gtsqyfj	355	18	inhibitor	inhibitor	NN
cord-291950-9gtsqyfj	355	19	for	for	IN
cord-291950-9gtsqyfj	355	20	papain	papain	NN
cord-291950-9gtsqyfj	355	21	and	and	CC
cord-291950-9gtsqyfj	355	22	other	other	JJ
cord-291950-9gtsqyfj	355	23	members	member	NNS
cord-291950-9gtsqyfj	355	24	of	of	IN
cord-291950-9gtsqyfj	355	25	family	family	NN
cord-291950-9gtsqyfj	355	26	C1	C1	NNP
cord-291950-9gtsqyfj	355	27	(	(	-LRB-
cord-291950-9gtsqyfj	355	28	Chapter	chapter	NN
cord-291950-9gtsqyfj	355	29	419	419	CD
cord-291950-9gtsqyfj	355	30	)	)	-RRB-
cord-291950-9gtsqyfj	355	31	.	.	.
cord-291950-9gtsqyfj	356	1	CrmA	CrmA	NNP
cord-291950-9gtsqyfj	356	2	,	,	,
cord-291950-9gtsqyfj	356	3	a	a	DT
cord-291950-9gtsqyfj	356	4	serpin	serpin	NN
cord-291950-9gtsqyfj	356	5	from	from	IN
cord-291950-9gtsqyfj	356	6	cowpox	cowpox	NN
cord-291950-9gtsqyfj	356	7	virus	virus	NN
cord-291950-9gtsqyfj	356	8	,	,	,
cord-291950-9gtsqyfj	356	9	is	be	VBZ
cord-291950-9gtsqyfj	356	10	an	an	DT
cord-291950-9gtsqyfj	356	11	inhibitor	inhibitor	NN
cord-291950-9gtsqyfj	356	12	of	of	IN
cord-291950-9gtsqyfj	356	13	the	the	DT
cord-291950-9gtsqyfj	356	14	caspases	caspase	NNS
cord-291950-9gtsqyfj	356	15	[	[	-LRB-
cord-291950-9gtsqyfj	356	16	59	59	CD
cord-291950-9gtsqyfj	356	17	]	]	-RRB-
cord-291950-9gtsqyfj	356	18	that	that	WDT
cord-291950-9gtsqyfj	356	19	also	also	RB
cord-291950-9gtsqyfj	356	20	inhibits	inhibit	VBZ
cord-291950-9gtsqyfj	356	21	the	the	DT
cord-291950-9gtsqyfj	356	22	serine	serine	JJ
cord-291950-9gtsqyfj	356	23	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	356	24	granzyme	granzyme	NNS
cord-291950-9gtsqyfj	356	25	B	B	NNP
cord-291950-9gtsqyfj	356	26	(	(	-LRB-
cord-291950-9gtsqyfj	356	27	Chapter	chapter	NN
cord-291950-9gtsqyfj	356	28	598	598	CD
cord-291950-9gtsqyfj	356	29	)	)	-RRB-
cord-291950-9gtsqyfj	356	30	[	[	-LRB-
cord-291950-9gtsqyfj	356	31	60	60	CD
cord-291950-9gtsqyfj	356	32	]	]	-RRB-
cord-291950-9gtsqyfj	356	33	.	.	.
cord-291950-9gtsqyfj	357	1	Rather	rather	RB
cord-291950-9gtsqyfj	357	2	than	than	IN
cord-291950-9gtsqyfj	357	3	reflecting	reflect	VBG
cord-291950-9gtsqyfj	357	4	any	any	DT
cord-291950-9gtsqyfj	357	5	structural	structural	JJ
cord-291950-9gtsqyfj	357	6	relationship	relationship	NN
cord-291950-9gtsqyfj	357	7	,	,	,
cord-291950-9gtsqyfj	357	8	however	however	RB
cord-291950-9gtsqyfj	357	9	,	,	,
cord-291950-9gtsqyfj	357	10	this	this	DT
cord-291950-9gtsqyfj	357	11	is	be	VBZ
cord-291950-9gtsqyfj	357	12	undoubtedly	undoubtedly	RB
cord-291950-9gtsqyfj	357	13	the	the	DT
cord-291950-9gtsqyfj	357	14	result	result	NN
cord-291950-9gtsqyfj	357	15	of	of	IN
cord-291950-9gtsqyfj	357	16	a	a	DT
cord-291950-9gtsqyfj	357	17	similar	similar	JJ
cord-291950-9gtsqyfj	357	18	specificity	specificity	NN
cord-291950-9gtsqyfj	357	19	of	of	IN
cord-291950-9gtsqyfj	357	20	the	the	DT
cord-291950-9gtsqyfj	357	21	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	357	22	for	for	IN
cord-291950-9gtsqyfj	357	23	aspartyl	aspartyl	NNP
cord-291950-9gtsqyfj	357	24	bonds	bond	NNS
cord-291950-9gtsqyfj	357	25	.	.	.
cord-291950-9gtsqyfj	358	1	Family	Family	NNP
cord-291950-9gtsqyfj	358	2	C14	C14	NNP
cord-291950-9gtsqyfj	358	3	comprises	comprise	VBZ
cord-291950-9gtsqyfj	358	4	a	a	DT
cord-291950-9gtsqyfj	358	5	number	number	NN
cord-291950-9gtsqyfj	358	6	of	of	IN
cord-291950-9gtsqyfj	358	7	cytosolic	cytosolic	JJ
cord-291950-9gtsqyfj	358	8	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	358	9	that	that	WDT
cord-291950-9gtsqyfj	358	10	have	have	VBP
cord-291950-9gtsqyfj	358	11	strict	strict	JJ
cord-291950-9gtsqyfj	358	12	specificity	specificity	NN
cord-291950-9gtsqyfj	358	13	for	for	IN
cord-291950-9gtsqyfj	358	14	hydrolysis	hydrolysis	NN
cord-291950-9gtsqyfj	358	15	of	of	IN
cord-291950-9gtsqyfj	358	16	aspartyl	aspartyl	NNP
cord-291950-9gtsqyfj	358	17	bonds	bond	NNS
cord-291950-9gtsqyfj	358	18	,	,	,
cord-291950-9gtsqyfj	358	19	the	the	DT
cord-291950-9gtsqyfj	358	20	best	well	RBS
cord-291950-9gtsqyfj	358	21	known	know	VBN
cord-291950-9gtsqyfj	358	22	of	of	IN
cord-291950-9gtsqyfj	358	23	which	which	WDT
cord-291950-9gtsqyfj	358	24	are	be	VBP
cord-291950-9gtsqyfj	358	25	caspase-1	caspase-1	NNP
cord-291950-9gtsqyfj	358	26	(	(	-LRB-
cord-291950-9gtsqyfj	358	27	Chapter	chapter	NN
cord-291950-9gtsqyfj	358	28	505	505	CD
cord-291950-9gtsqyfj	358	29	)	)	-RRB-
cord-291950-9gtsqyfj	358	30	and	and	CC
cord-291950-9gtsqyfj	358	31	caspase-3	caspase-3	NNP
cord-291950-9gtsqyfj	358	32	(	(	-LRB-
cord-291950-9gtsqyfj	358	33	Chapter	chapter	NN
cord-291950-9gtsqyfj	358	34	509	509	CD
cord-291950-9gtsqyfj	358	35	)	)	-RRB-
cord-291950-9gtsqyfj	358	36	.	.	.
cord-291950-9gtsqyfj	359	1	As	as	IN
cord-291950-9gtsqyfj	359	2	can	can	MD
cord-291950-9gtsqyfj	359	3	be	be	VB
cord-291950-9gtsqyfj	359	4	seen	see	VBN
cord-291950-9gtsqyfj	359	5	in	in	IN
cord-291950-9gtsqyfj	359	6	the	the	DT
cord-291950-9gtsqyfj	359	7	alignment	alignment	NN
cord-291950-9gtsqyfj	359	8	in	in	IN
cord-291950-9gtsqyfj	359	9	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	359	10	,	,	,
cord-291950-9gtsqyfj	359	11	there	there	EX
cord-291950-9gtsqyfj	359	12	is	be	VBZ
cord-291950-9gtsqyfj	359	13	a	a	DT
cord-291950-9gtsqyfj	359	14	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	359	15	dyad	dyad	NN
cord-291950-9gtsqyfj	359	16	in	in	IN
cord-291950-9gtsqyfj	359	17	the	the	DT
cord-291950-9gtsqyfj	359	18	order	order	NN
cord-291950-9gtsqyfj	359	19	His	-PRON-	PRP$
cord-291950-9gtsqyfj	359	20	,	,	,
cord-291950-9gtsqyfj	359	21	Cys	Cys	NNP
cord-291950-9gtsqyfj	359	22	in	in	IN
cord-291950-9gtsqyfj	359	23	the	the	DT
cord-291950-9gtsqyfj	359	24	sequence	sequence	NN
cord-291950-9gtsqyfj	359	25	,	,	,
cord-291950-9gtsqyfj	359	26	as	as	IN
cord-291950-9gtsqyfj	359	27	expected	expect	VBN
cord-291950-9gtsqyfj	359	28	in	in	IN
cord-291950-9gtsqyfj	359	29	clan	clan	NN
cord-291950-9gtsqyfj	359	30	CD	cd	NN
cord-291950-9gtsqyfj	359	31	.	.	.
cord-291950-9gtsqyfj	360	1	Caspase-1	Caspase-1	NNP
cord-291950-9gtsqyfj	360	2	is	be	VBZ
cord-291950-9gtsqyfj	360	3	synthesized	synthesize	VBN
cord-291950-9gtsqyfj	360	4	as	as	IN
cord-291950-9gtsqyfj	360	5	a	a	DT
cord-291950-9gtsqyfj	360	6	single	single	JJ
cord-291950-9gtsqyfj	360	7	-	-	HYPH
cord-291950-9gtsqyfj	360	8	chain	chain	NN
cord-291950-9gtsqyfj	360	9	precursor	precursor	NN
cord-291950-9gtsqyfj	360	10	,	,	,
cord-291950-9gtsqyfj	360	11	and	and	CC
cord-291950-9gtsqyfj	360	12	the	the	DT
cord-291950-9gtsqyfj	360	13	activation	activation	NN
cord-291950-9gtsqyfj	360	14	by	by	IN
cord-291950-9gtsqyfj	360	15	cleavage	cleavage	NN
cord-291950-9gtsqyfj	360	16	of	of	IN
cord-291950-9gtsqyfj	360	17	four	four	CD
cord-291950-9gtsqyfj	360	18	aspartyl	aspartyl	NNP
cord-291950-9gtsqyfj	360	19	bonds	bond	NNS
cord-291950-9gtsqyfj	360	20	is	be	VBZ
cord-291950-9gtsqyfj	360	21	presumably	presumably	RB
cord-291950-9gtsqyfj	360	22	autocatalytic	autocatalytic	JJ
cord-291950-9gtsqyfj	360	23	.	.	.
cord-291950-9gtsqyfj	361	1	The	the	DT
cord-291950-9gtsqyfj	361	2	mature	mature	JJ
cord-291950-9gtsqyfj	361	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	361	4	is	be	VBZ
cord-291950-9gtsqyfj	361	5	a	a	DT
cord-291950-9gtsqyfj	361	6	heterodimer	heterodimer	NN
cord-291950-9gtsqyfj	361	7	of	of	IN
cord-291950-9gtsqyfj	361	8	a	a	DT
cord-291950-9gtsqyfj	361	9	22	22	CD
cord-291950-9gtsqyfj	361	10	kDa	kDa	NNS
cord-291950-9gtsqyfj	361	11	heavy	heavy	JJ
cord-291950-9gtsqyfj	361	12	chain	chain	NN
cord-291950-9gtsqyfj	361	13	and	and	CC
cord-291950-9gtsqyfj	361	14	a	a	DT
cord-291950-9gtsqyfj	361	15	10	10	CD
cord-291950-9gtsqyfj	361	16	kDa	kDa	NNP
cord-291950-9gtsqyfj	361	17	light	light	NN
cord-291950-9gtsqyfj	361	18	chain	chain	NN
cord-291950-9gtsqyfj	361	19	[	[	-LRB-
cord-291950-9gtsqyfj	361	20	61	61	CD
cord-291950-9gtsqyfj	361	21	]	]	-RRB-
cord-291950-9gtsqyfj	361	22	.	.	.
cord-291950-9gtsqyfj	362	1	Caspase-1	Caspase-1	NNP
cord-291950-9gtsqyfj	362	2	also	also	RB
cord-291950-9gtsqyfj	362	3	mediates	mediate	VBZ
cord-291950-9gtsqyfj	362	4	the	the	DT
cord-291950-9gtsqyfj	362	5	processing	processing	NN
cord-291950-9gtsqyfj	362	6	of	of	IN
cord-291950-9gtsqyfj	362	7	interleukin	interleukin	NN
cord-291950-9gtsqyfj	362	8	1	1	CD
cord-291950-9gtsqyfj	362	9	β	β	NN
cord-291950-9gtsqyfj	362	10	at	at	IN
cord-291950-9gtsqyfj	362	11	aspartyl	aspartyl	NNP
cord-291950-9gtsqyfj	362	12	bonds	bonds	NNP
cord-291950-9gtsqyfj	362	13	[	[	-LRB-
cord-291950-9gtsqyfj	362	14	62	62	CD
cord-291950-9gtsqyfj	362	15	]	]	-RRB-
cord-291950-9gtsqyfj	362	16	,	,	,
cord-291950-9gtsqyfj	362	17	and	and	CC
cord-291950-9gtsqyfj	362	18	was	be	VBD
cord-291950-9gtsqyfj	362	19	formerly	formerly	RB
cord-291950-9gtsqyfj	362	20	known	know	VBN
cord-291950-9gtsqyfj	362	21	as	as	IN
cord-291950-9gtsqyfj	362	22	interleukin	interleukin	NN
cord-291950-9gtsqyfj	362	23	1	1	CD
cord-291950-9gtsqyfj	362	24	β	β	NN
cord-291950-9gtsqyfj	362	25	-	-	HYPH
cord-291950-9gtsqyfj	362	26	converting	convert	VBG
cord-291950-9gtsqyfj	362	27	enzyme	enzyme	NN
cord-291950-9gtsqyfj	362	28	(	(	-LRB-
cord-291950-9gtsqyfj	362	29	ICE	ice	NN
cord-291950-9gtsqyfj	362	30	)	)	-RRB-
cord-291950-9gtsqyfj	362	31	.	.	.
cord-291950-9gtsqyfj	363	1	The	the	DT
cord-291950-9gtsqyfj	363	2	discovery	discovery	NN
cord-291950-9gtsqyfj	363	3	that	that	IN
cord-291950-9gtsqyfj	363	4	the	the	DT
cord-291950-9gtsqyfj	363	5	product	product	NN
cord-291950-9gtsqyfj	363	6	of	of	IN
cord-291950-9gtsqyfj	363	7	the	the	DT
cord-291950-9gtsqyfj	363	8	ced3	ced3	VBN
cord-291950-9gtsqyfj	363	9	gene	gene	NN
cord-291950-9gtsqyfj	363	10	in	in	IN
cord-291950-9gtsqyfj	363	11	Caenorhabditis	Caenorhabditis	NNP
cord-291950-9gtsqyfj	363	12	elegans	elegan	NNS
cord-291950-9gtsqyfj	363	13	,	,	,
cord-291950-9gtsqyfj	363	14	which	which	WDT
cord-291950-9gtsqyfj	363	15	when	when	WRB
cord-291950-9gtsqyfj	363	16	defective	defective	JJ
cord-291950-9gtsqyfj	363	17	increases	increase	VBZ
cord-291950-9gtsqyfj	363	18	the	the	DT
cord-291950-9gtsqyfj	363	19	lifespan	lifespan	NN
cord-291950-9gtsqyfj	363	20	of	of	IN
cord-291950-9gtsqyfj	363	21	the	the	DT
cord-291950-9gtsqyfj	363	22	nematode	nematode	NN
cord-291950-9gtsqyfj	363	23	[	[	-LRB-
cord-291950-9gtsqyfj	363	24	63	63	CD
cord-291950-9gtsqyfj	363	25	]	]	-RRB-
cord-291950-9gtsqyfj	363	26	is	be	VBZ
cord-291950-9gtsqyfj	363	27	a	a	DT
cord-291950-9gtsqyfj	363	28	homolog	homolog	NN
cord-291950-9gtsqyfj	363	29	of	of	IN
cord-291950-9gtsqyfj	363	30	caspase-1	caspase-1	NNP
cord-291950-9gtsqyfj	363	31	led	lead	VBD
cord-291950-9gtsqyfj	363	32	to	to	IN
cord-291950-9gtsqyfj	363	33	the	the	DT
cord-291950-9gtsqyfj	363	34	discovery	discovery	NN
cord-291950-9gtsqyfj	363	35	of	of	IN
cord-291950-9gtsqyfj	363	36	a	a	DT
cord-291950-9gtsqyfj	363	37	proteolytic	proteolytic	JJ
cord-291950-9gtsqyfj	363	38	cascade	cascade	NN
cord-291950-9gtsqyfj	363	39	that	that	WDT
cord-291950-9gtsqyfj	363	40	leads	lead	VBZ
cord-291950-9gtsqyfj	363	41	to	to	IN
cord-291950-9gtsqyfj	363	42	apoptosis	apoptosis	NN
cord-291950-9gtsqyfj	363	43	in	in	IN
cord-291950-9gtsqyfj	363	44	mammalian	mammalian	JJ
cord-291950-9gtsqyfj	363	45	cells	cell	NNS
cord-291950-9gtsqyfj	363	46	.	.	.
cord-291950-9gtsqyfj	364	1	Apoptosis	apoptosis	NN
cord-291950-9gtsqyfj	364	2	is	be	VBZ
cord-291950-9gtsqyfj	364	3	receptor	receptor	NN
cord-291950-9gtsqyfj	364	4	mediated	mediate	VBN
cord-291950-9gtsqyfj	364	5	,	,	,
cord-291950-9gtsqyfj	364	6	and	and	CC
cord-291950-9gtsqyfj	364	7	once	once	IN
cord-291950-9gtsqyfj	364	8	the	the	DT
cord-291950-9gtsqyfj	364	9	system	system	NN
cord-291950-9gtsqyfj	364	10	is	be	VBZ
cord-291950-9gtsqyfj	364	11	activated	activate	VBN
cord-291950-9gtsqyfj	364	12	,	,	,
cord-291950-9gtsqyfj	364	13	proteins	protein	NNS
cord-291950-9gtsqyfj	364	14	associate	associate	VBP
cord-291950-9gtsqyfj	364	15	with	with	IN
cord-291950-9gtsqyfj	364	16	one	one	CD
cord-291950-9gtsqyfj	364	17	another	another	DT
cord-291950-9gtsqyfj	364	18	by	by	IN
cord-291950-9gtsqyfj	364	19	means	mean	NNS
cord-291950-9gtsqyfj	364	20	of	of	IN
cord-291950-9gtsqyfj	364	21	'	'	``
cord-291950-9gtsqyfj	364	22	death	death	NN
cord-291950-9gtsqyfj	364	23	domains	domain	NNS
cord-291950-9gtsqyfj	364	24	'	'	POS
cord-291950-9gtsqyfj	364	25	and	and	CC
cord-291950-9gtsqyfj	364	26	'	'	``
cord-291950-9gtsqyfj	364	27	deatheffector	deatheffector	NN
cord-291950-9gtsqyfj	364	28	domains	domain	NNS
cord-291950-9gtsqyfj	364	29	'	'	''
cord-291950-9gtsqyfj	364	30	.	.	.
cord-291950-9gtsqyfj	365	1	Death	death	NN
cord-291950-9gtsqyfj	365	2	-	-	HYPH
cord-291950-9gtsqyfj	365	3	effector	effector	NN
cord-291950-9gtsqyfj	365	4	domains	domain	NNS
cord-291950-9gtsqyfj	365	5	occur	occur	VBP
cord-291950-9gtsqyfj	365	6	in	in	IN
cord-291950-9gtsqyfj	365	7	a	a	DT
cord-291950-9gtsqyfj	365	8	number	number	NN
cord-291950-9gtsqyfj	365	9	of	of	IN
cord-291950-9gtsqyfj	365	10	intracellular	intracellular	JJ
cord-291950-9gtsqyfj	365	11	proteins	protein	NNS
cord-291950-9gtsqyfj	365	12	and	and	CC
cord-291950-9gtsqyfj	365	13	in	in	IN
cord-291950-9gtsqyfj	365	14	caspases-8	caspases-8	NNP
cord-291950-9gtsqyfj	366	1	and	and	CC
cord-291950-9gtsqyfj	366	2	-10	-10	IN
cord-291950-9gtsqyfj	366	3	[	[	-LRB-
cord-291950-9gtsqyfj	366	4	64	64	CD
cord-291950-9gtsqyfj	366	5	]	]	-RRB-
cord-291950-9gtsqyfj	366	6	.	.	.
cord-291950-9gtsqyfj	367	1	FLIP	FLIP	NNP
cord-291950-9gtsqyfj	367	2	,	,	,
cord-291950-9gtsqyfj	367	3	a	a	DT
cord-291950-9gtsqyfj	367	4	newly	newly	RB
cord-291950-9gtsqyfj	367	5	reported	report	VBN
cord-291950-9gtsqyfj	367	6	inhibitor	inhibitor	NN
cord-291950-9gtsqyfj	367	7	of	of	IN
cord-291950-9gtsqyfj	367	8	caspase-8	caspase-8	NNP
cord-291950-9gtsqyfj	367	9	,	,	,
cord-291950-9gtsqyfj	367	10	occurs	occur	VBZ
cord-291950-9gtsqyfj	367	11	in	in	IN
cord-291950-9gtsqyfj	367	12	two	two	CD
cord-291950-9gtsqyfj	367	13	alternatively	alternatively	RB
cord-291950-9gtsqyfj	367	14	spliced	splice	VBN
cord-291950-9gtsqyfj	367	15	forms	form	NNS
cord-291950-9gtsqyfj	367	16	,	,	,
cord-291950-9gtsqyfj	367	17	the	the	DT
cord-291950-9gtsqyfj	367	18	longer	long	JJR
cord-291950-9gtsqyfj	367	19	of	of	IN
cord-291950-9gtsqyfj	367	20	which	which	WDT
cord-291950-9gtsqyfj	367	21	,	,	,
cord-291950-9gtsqyfj	367	22	FLIP	FLIP	NNP
cord-291950-9gtsqyfj	367	23	L	L	NNP
cord-291950-9gtsqyfj	367	24	,	,	,
cord-291950-9gtsqyfj	367	25	contains	contain	VBZ
cord-291950-9gtsqyfj	367	26	two	two	CD
cord-291950-9gtsqyfj	367	27	death	death	NN
cord-291950-9gtsqyfj	367	28	-	-	HYPH
cord-291950-9gtsqyfj	367	29	effector	effector	NN
cord-291950-9gtsqyfj	367	30	domains	domain	NNS
cord-291950-9gtsqyfj	367	31	,	,	,
cord-291950-9gtsqyfj	367	32	and	and	CC
cord-291950-9gtsqyfj	367	33	a	a	DT
cord-291950-9gtsqyfj	367	34	caspase	caspase	NN
cord-291950-9gtsqyfj	367	35	-	-	HYPH
cord-291950-9gtsqyfj	367	36	like	like	JJ
cord-291950-9gtsqyfj	367	37	domain	domain	NN
cord-291950-9gtsqyfj	367	38	in	in	IN
cord-291950-9gtsqyfj	367	39	which	which	WDT
cord-291950-9gtsqyfj	367	40	the	the	DT
cord-291950-9gtsqyfj	367	41	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	367	42	Cys	Cys	NNP
cord-291950-9gtsqyfj	367	43	is	be	VBZ
cord-291950-9gtsqyfj	367	44	replaced	replace	VBN
cord-291950-9gtsqyfj	367	45	by	by	IN
cord-291950-9gtsqyfj	367	46	Tyr	Tyr	NNP
cord-291950-9gtsqyfj	367	47	,	,	,
cord-291950-9gtsqyfj	367	48	and	and	CC
cord-291950-9gtsqyfj	367	49	the	the	DT
cord-291950-9gtsqyfj	367	50	His	-PRON-	PRP$
cord-291950-9gtsqyfj	367	51	by	by	IN
cord-291950-9gtsqyfj	367	52	Arg	arg	NN
cord-291950-9gtsqyfj	367	53	(	(	-LRB-
cord-291950-9gtsqyfj	367	54	human	human	JJ
cord-291950-9gtsqyfj	367	55	)	)	-RRB-
cord-291950-9gtsqyfj	367	56	or	or	CC
cord-291950-9gtsqyfj	367	57	Leu	Leu	NNP
cord-291950-9gtsqyfj	367	58	(	(	-LRB-
cord-291950-9gtsqyfj	367	59	mouse	mouse	NN
cord-291950-9gtsqyfj	367	60	)	)	-RRB-
cord-291950-9gtsqyfj	367	61	[	[	-LRB-
cord-291950-9gtsqyfj	367	62	65	65	CD
cord-291950-9gtsqyfj	367	63	]	]	-RRB-
cord-291950-9gtsqyfj	368	1	(	(	-LRB-
cord-291950-9gtsqyfj	368	2	see	see	VB
cord-291950-9gtsqyfj	368	3	the	the	DT
cord-291950-9gtsqyfj	368	4	alignment	alignment	NN
cord-291950-9gtsqyfj	368	5	for	for	IN
cord-291950-9gtsqyfj	368	6	family	family	NN
cord-291950-9gtsqyfj	368	7	C14	C14	NNP
cord-291950-9gtsqyfj	368	8	in	in	IN
cord-291950-9gtsqyfj	368	9	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	368	10	)	)	-RRB-
cord-291950-9gtsqyfj	368	11	.	.	.
cord-291950-9gtsqyfj	369	1	The	the	DT
cord-291950-9gtsqyfj	369	2	evolutionary	evolutionary	JJ
cord-291950-9gtsqyfj	369	3	tree	tree	NN
cord-291950-9gtsqyfj	369	4	shows	show	VBZ
cord-291950-9gtsqyfj	369	5	a	a	DT
cord-291950-9gtsqyfj	369	6	pronounced	pronounce	VBN
cord-291950-9gtsqyfj	369	7	divergence	divergence	NN
cord-291950-9gtsqyfj	369	8	within	within	IN
cord-291950-9gtsqyfj	369	9	the	the	DT
cord-291950-9gtsqyfj	369	10	family	family	NN
cord-291950-9gtsqyfj	369	11	,	,	,
cord-291950-9gtsqyfj	369	12	which	which	WDT
cord-291950-9gtsqyfj	369	13	is	be	VBZ
cord-291950-9gtsqyfj	369	14	therefore	therefore	RB
cord-291950-9gtsqyfj	369	15	divided	divide	VBN
cord-291950-9gtsqyfj	369	16	into	into	IN
cord-291950-9gtsqyfj	369	17	two	two	CD
cord-291950-9gtsqyfj	369	18	subfamilies	subfamily	NNS
cord-291950-9gtsqyfj	369	19	.	.	.
cord-291950-9gtsqyfj	370	1	Subfamily	Subfamily	NNP
cord-291950-9gtsqyfj	370	2	C14A	C14A	NNP
cord-291950-9gtsqyfj	370	3	includes	include	VBZ
cord-291950-9gtsqyfj	370	4	caspases	caspase	NNS
cord-291950-9gtsqyfj	370	5	,	,	,
cord-291950-9gtsqyfj	370	6	whereas	whereas	IN
cord-291950-9gtsqyfj	370	7	subfamily	subfamily	NN
cord-291950-9gtsqyfj	370	8	C14B	C14B	NNP
cord-291950-9gtsqyfj	370	9	includes	include	VBZ
cord-291950-9gtsqyfj	370	10	metacaspases	metacaspases	NNP
cord-291950-9gtsqyfj	370	11	(	(	-LRB-
cord-291950-9gtsqyfj	370	12	see	see	VB
cord-291950-9gtsqyfj	370	13	Chapter	chapter	NN
cord-291950-9gtsqyfj	370	14	517	517	CD
cord-291950-9gtsqyfj	370	15	)	)	-RRB-
cord-291950-9gtsqyfj	370	16	and	and	CC
cord-291950-9gtsqyfj	370	17	paracaspases	paracaspase	NNS
cord-291950-9gtsqyfj	370	18	(	(	-LRB-
cord-291950-9gtsqyfj	370	19	see	see	VB
cord-291950-9gtsqyfj	370	20	Chapter	chapter	NN
cord-291950-9gtsqyfj	370	21	515	515	CD
cord-291950-9gtsqyfj	370	22	)	)	-RRB-
cord-291950-9gtsqyfj	370	23	.	.	.
cord-291950-9gtsqyfj	371	1	Paracaspase	Paracaspase	NNP
cord-291950-9gtsqyfj	371	2	is	be	VBZ
cord-291950-9gtsqyfj	371	3	known	know	VBN
cord-291950-9gtsqyfj	371	4	from	from	IN
cord-291950-9gtsqyfj	371	5	a	a	DT
cord-291950-9gtsqyfj	371	6	variety	variety	NN
cord-291950-9gtsqyfj	371	7	of	of	IN
cord-291950-9gtsqyfj	371	8	animal	animal	NN
cord-291950-9gtsqyfj	371	9	species	specie	NNS
cord-291950-9gtsqyfj	371	10	,	,	,
cord-291950-9gtsqyfj	371	11	including	include	VBG
cord-291950-9gtsqyfj	371	12	human	human	JJ
cord-291950-9gtsqyfj	371	13	,	,	,
cord-291950-9gtsqyfj	371	14	and	and	CC
cord-291950-9gtsqyfj	371	15	provides	provide	VBZ
cord-291950-9gtsqyfj	371	16	an	an	DT
cord-291950-9gtsqyfj	371	17	important	important	JJ
cord-291950-9gtsqyfj	371	18	link	link	NN
cord-291950-9gtsqyfj	371	19	to	to	IN
cord-291950-9gtsqyfj	371	20	a	a	DT
cord-291950-9gtsqyfj	371	21	number	number	NN
cord-291950-9gtsqyfj	371	22	of	of	IN
cord-291950-9gtsqyfj	371	23	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	371	24	species	specie	NNS
cord-291950-9gtsqyfj	371	25	,	,	,
cord-291950-9gtsqyfj	371	26	including	include	VBG
cord-291950-9gtsqyfj	371	27	homologs	homolog	NNS
cord-291950-9gtsqyfj	371	28	in	in	IN
cord-291950-9gtsqyfj	371	29	the	the	DT
cord-291950-9gtsqyfj	371	30	completed	complete	VBN
cord-291950-9gtsqyfj	371	31	genomes	genome	NNS
cord-291950-9gtsqyfj	371	32	of	of	IN
cord-291950-9gtsqyfj	371	33	Nostoc	Nostoc	NNP
cord-291950-9gtsqyfj	371	34	,	,	,
cord-291950-9gtsqyfj	371	35	Mesorhizobium	Mesorhizobium	NNP
cord-291950-9gtsqyfj	371	36	loti	loti	NNP
cord-291950-9gtsqyfj	371	37	and	and	CC
cord-291950-9gtsqyfj	372	1	Xylella	Xylella	NNP
cord-291950-9gtsqyfj	372	2	fastidiosa	fastidiosa	RB
cord-291950-9gtsqyfj	372	3	[	[	-LRB-
cord-291950-9gtsqyfj	372	4	58	58	CD
cord-291950-9gtsqyfj	372	5	]	]	-RRB-
cord-291950-9gtsqyfj	372	6	.	.	.
cord-291950-9gtsqyfj	373	1	The	the	DT
cord-291950-9gtsqyfj	373	2	family	family	NN
cord-291950-9gtsqyfj	373	3	is	be	VBZ
cord-291950-9gtsqyfj	373	4	generally	generally	RB
cord-291950-9gtsqyfj	373	5	absent	absent	JJ
cord-291950-9gtsqyfj	373	6	from	from	IN
cord-291950-9gtsqyfj	373	7	archaea	archaea	NNS
cord-291950-9gtsqyfj	373	8	,	,	,
cord-291950-9gtsqyfj	373	9	but	but	CC
cord-291950-9gtsqyfj	373	10	homologs	homolog	NNS
cord-291950-9gtsqyfj	373	11	have	have	VBP
cord-291950-9gtsqyfj	373	12	been	be	VBN
cord-291950-9gtsqyfj	373	13	detected	detect	VBN
cord-291950-9gtsqyfj	373	14	in	in	IN
cord-291950-9gtsqyfj	373	15	the	the	DT
cord-291950-9gtsqyfj	373	16	proteomes	proteome	NNS
cord-291950-9gtsqyfj	373	17	of	of	IN
cord-291950-9gtsqyfj	373	18	Methanosarcina	Methanosarcina	NNP
cord-291950-9gtsqyfj	373	19	barkeri	barkeri	NNP
cord-291950-9gtsqyfj	373	20	,	,	,
cord-291950-9gtsqyfj	373	21	Methanothermus	Methanothermus	NNP
cord-291950-9gtsqyfj	373	22	fervidus	fervidus	NNP
cord-291950-9gtsqyfj	373	23	and	and	CC
cord-291950-9gtsqyfj	373	24	Thermococcus	Thermococcus	NNP
cord-291950-9gtsqyfj	373	25	onnurineus	onnurineu	NNS
cord-291950-9gtsqyfj	373	26	,	,	,
cord-291950-9gtsqyfj	373	27	which	which	WDT
cord-291950-9gtsqyfj	373	28	are	be	VBP
cord-291950-9gtsqyfj	373	29	presumably	presumably	RB
cord-291950-9gtsqyfj	373	30	derived	derive	VBN
cord-291950-9gtsqyfj	373	31	from	from	IN
cord-291950-9gtsqyfj	373	32	horizontal	horizontal	JJ
cord-291950-9gtsqyfj	373	33	gene	gene	NN
cord-291950-9gtsqyfj	373	34	transfers	transfer	NNS
cord-291950-9gtsqyfj	373	35	.	.	.
cord-291950-9gtsqyfj	374	1	There	there	EX
cord-291950-9gtsqyfj	374	2	are	be	VBP
cord-291950-9gtsqyfj	374	3	also	also	RB
cord-291950-9gtsqyfj	374	4	homologs	homolog	NNS
cord-291950-9gtsqyfj	374	5	in	in	IN
cord-291950-9gtsqyfj	374	6	two	two	CD
cord-291950-9gtsqyfj	374	7	insect	insect	NN
cord-291950-9gtsqyfj	374	8	ascoviruses	ascoviruse	NNS
cord-291950-9gtsqyfj	374	9	,	,	,
cord-291950-9gtsqyfj	374	10	which	which	WDT
cord-291950-9gtsqyfj	374	11	are	be	VBP
cord-291950-9gtsqyfj	374	12	double	double	RB
cord-291950-9gtsqyfj	374	13	-	-	HYPH
cord-291950-9gtsqyfj	374	14	stranded	strand	VBN
cord-291950-9gtsqyfj	374	15	DNA	dna	NN
cord-291950-9gtsqyfj	374	16	viruses	virus	NNS
cord-291950-9gtsqyfj	374	17	.	.	.
cord-291950-9gtsqyfj	375	1	Family	Family	NNP
cord-291950-9gtsqyfj	375	2	C13	C13	NNP
cord-291950-9gtsqyfj	375	3	includes	include	VBZ
cord-291950-9gtsqyfj	375	4	a	a	DT
cord-291950-9gtsqyfj	375	5	number	number	NN
cord-291950-9gtsqyfj	375	6	of	of	IN
cord-291950-9gtsqyfj	375	7	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	375	8	that	that	WDT
cord-291950-9gtsqyfj	375	9	specifically	specifically	RB
cord-291950-9gtsqyfj	375	10	cleave	cleave	VBP
cord-291950-9gtsqyfj	375	11	asparaginyl	asparaginyl	NN
cord-291950-9gtsqyfj	375	12	bonds	bond	NNS
cord-291950-9gtsqyfj	375	13	.	.	.
cord-291950-9gtsqyfj	376	1	An	an	DT
cord-291950-9gtsqyfj	376	2	asparaginyl	asparaginyl	NN
cord-291950-9gtsqyfj	376	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	376	4	was	be	VBD
cord-291950-9gtsqyfj	376	5	first	first	RB
cord-291950-9gtsqyfj	376	6	identified	identify	VBN
cord-291950-9gtsqyfj	376	7	in	in	IN
cord-291950-9gtsqyfj	376	8	seeds	seed	NNS
cord-291950-9gtsqyfj	376	9	of	of	IN
cord-291950-9gtsqyfj	376	10	leguminous	leguminous	JJ
cord-291950-9gtsqyfj	376	11	plants	plant	NNS
cord-291950-9gtsqyfj	376	12	and	and	CC
cord-291950-9gtsqyfj	376	13	was	be	VBD
cord-291950-9gtsqyfj	376	14	named	name	VBN
cord-291950-9gtsqyfj	376	15	'	'	``
cord-291950-9gtsqyfj	376	16	legumain	legumain	NN
cord-291950-9gtsqyfj	376	17	'	'	''
cord-291950-9gtsqyfj	376	18	[	[	-LRB-
cord-291950-9gtsqyfj	376	19	66	66	CD
cord-291950-9gtsqyfj	376	20	]	]	-RRB-
cord-291950-9gtsqyfj	376	21	.	.	.
cord-291950-9gtsqyfj	377	1	The	the	DT
cord-291950-9gtsqyfj	377	2	legumain	legumain	NN
cord-291950-9gtsqyfj	377	3	of	of	IN
cord-291950-9gtsqyfj	377	4	plant	plant	NN
cord-291950-9gtsqyfj	377	5	seeds	seed	NNS
cord-291950-9gtsqyfj	377	6	has	have	VBZ
cord-291950-9gtsqyfj	377	7	now	now	RB
cord-291950-9gtsqyfj	377	8	been	be	VBN
cord-291950-9gtsqyfj	377	9	found	find	VBN
cord-291950-9gtsqyfj	377	10	in	in	IN
cord-291950-9gtsqyfj	377	11	a	a	DT
cord-291950-9gtsqyfj	377	12	wide	wide	JJ
cord-291950-9gtsqyfj	377	13	variety	variety	NN
cord-291950-9gtsqyfj	377	14	of	of	IN
cord-291950-9gtsqyfj	377	15	dicotyledonous	dicotyledonous	JJ
cord-291950-9gtsqyfj	377	16	plants	plant	NNS
cord-291950-9gtsqyfj	377	17	and	and	CC
cord-291950-9gtsqyfj	377	18	is	be	VBZ
cord-291950-9gtsqyfj	377	19	proposed	propose	VBN
cord-291950-9gtsqyfj	377	20	to	to	TO
cord-291950-9gtsqyfj	377	21	be	be	VB
cord-291950-9gtsqyfj	377	22	responsible	responsible	JJ
cord-291950-9gtsqyfj	377	23	for	for	IN
cord-291950-9gtsqyfj	377	24	the	the	DT
cord-291950-9gtsqyfj	377	25	post	post	JJ
cord-291950-9gtsqyfj	377	26	-	-	JJ
cord-291950-9gtsqyfj	377	27	translational	translational	JJ
cord-291950-9gtsqyfj	377	28	processing	processing	NN
cord-291950-9gtsqyfj	377	29	of	of	IN
cord-291950-9gtsqyfj	377	30	seed	seed	NN
cord-291950-9gtsqyfj	377	31	proteins	protein	NNS
cord-291950-9gtsqyfj	377	32	prior	prior	RB
cord-291950-9gtsqyfj	377	33	to	to	IN
cord-291950-9gtsqyfj	377	34	storage	storage	NN
cord-291950-9gtsqyfj	377	35	[	[	-LRB-
cord-291950-9gtsqyfj	377	36	67	67	CD
cord-291950-9gtsqyfj	377	37	]	]	-RRB-
cord-291950-9gtsqyfj	377	38	.	.	.
cord-291950-9gtsqyfj	378	1	The	the	DT
cord-291950-9gtsqyfj	378	2	processing	processing	NN
cord-291950-9gtsqyfj	378	3	of	of	IN
cord-291950-9gtsqyfj	378	4	a	a	DT
cord-291950-9gtsqyfj	378	5	few	few	JJ
cord-291950-9gtsqyfj	378	6	of	of	IN
cord-291950-9gtsqyfj	378	7	these	these	DT
cord-291950-9gtsqyfj	378	8	proteins	protein	NNS
cord-291950-9gtsqyfj	378	9	,	,	,
cord-291950-9gtsqyfj	378	10	such	such	JJ
cord-291950-9gtsqyfj	378	11	as	as	IN
cord-291950-9gtsqyfj	378	12	concanavalin	concanavalin	NNP
cord-291950-9gtsqyfj	378	13	A	A	NNP
cord-291950-9gtsqyfj	378	14	,	,	,
cord-291950-9gtsqyfj	378	15	also	also	RB
cord-291950-9gtsqyfj	378	16	involves	involve	VBZ
cord-291950-9gtsqyfj	378	17	protein	protein	NN
cord-291950-9gtsqyfj	378	18	splicing	splice	VBG
cord-291950-9gtsqyfj	378	19	at	at	IN
cord-291950-9gtsqyfj	378	20	asparaginyl	asparaginyl	NNP
cord-291950-9gtsqyfj	378	21	bonds	bond	NNS
cord-291950-9gtsqyfj	378	22	,	,	,
cord-291950-9gtsqyfj	378	23	and	and	CC
cord-291950-9gtsqyfj	378	24	this	this	DT
cord-291950-9gtsqyfj	378	25	transamidase	transamidase	NN
cord-291950-9gtsqyfj	378	26	reaction	reaction	NN
cord-291950-9gtsqyfj	378	27	also	also	RB
cord-291950-9gtsqyfj	378	28	can	can	MD
cord-291950-9gtsqyfj	378	29	be	be	VB
cord-291950-9gtsqyfj	378	30	mediated	mediate	VBN
cord-291950-9gtsqyfj	378	31	by	by	IN
cord-291950-9gtsqyfj	378	32	legumain	legumain	NN
cord-291950-9gtsqyfj	378	33	[	[	-LRB-
cord-291950-9gtsqyfj	378	34	68	68	CD
cord-291950-9gtsqyfj	378	35	]	]	-RRB-
cord-291950-9gtsqyfj	378	36	.	.	.
cord-291950-9gtsqyfj	379	1	Homologous	homologous	JJ
cord-291950-9gtsqyfj	379	2	asparaginyl	asparaginyl	NN
cord-291950-9gtsqyfj	379	3	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	379	4	have	have	VBP
cord-291950-9gtsqyfj	379	5	been	be	VBN
cord-291950-9gtsqyfj	379	6	characterized	characterize	VBN
cord-291950-9gtsqyfj	379	7	from	from	IN
cord-291950-9gtsqyfj	379	8	the	the	DT
cord-291950-9gtsqyfj	379	9	blood	blood	NN
cord-291950-9gtsqyfj	379	10	flukes	fluke	NNS
cord-291950-9gtsqyfj	379	11	Schistosoma	Schistosoma	NNP
cord-291950-9gtsqyfj	379	12	mansoni	mansoni	NNP
cord-291950-9gtsqyfj	379	13	and	and	CC
cord-291950-9gtsqyfj	379	14	S.	S.	NNP
cord-291950-9gtsqyfj	379	15	japonicum	japonicum	NN
cord-291950-9gtsqyfj	379	16	;	;	:
cord-291950-9gtsqyfj	379	17	they	-PRON-	PRP
cord-291950-9gtsqyfj	379	18	were	be	VBD
cord-291950-9gtsqyfj	379	19	initially	initially	RB
cord-291950-9gtsqyfj	379	20	thought	think	VBN
cord-291950-9gtsqyfj	379	21	to	to	TO
cord-291950-9gtsqyfj	379	22	be	be	VB
cord-291950-9gtsqyfj	379	23	responsible	responsible	JJ
cord-291950-9gtsqyfj	379	24	for	for	IN
cord-291950-9gtsqyfj	379	25	hemoglobin	hemoglobin	NN
cord-291950-9gtsqyfj	379	26	breakdown	breakdown	NN
cord-291950-9gtsqyfj	379	27	and	and	CC
cord-291950-9gtsqyfj	379	28	were	be	VBD
cord-291950-9gtsqyfj	379	29	termed	term	VBN
cord-291950-9gtsqyfj	379	30	'	'	``
cord-291950-9gtsqyfj	379	31	hemoglobinases	hemoglobinase	NNS
cord-291950-9gtsqyfj	379	32	'	'	''
cord-291950-9gtsqyfj	379	33	but	but	CC
cord-291950-9gtsqyfj	379	34	this	this	DT
cord-291950-9gtsqyfj	379	35	name	name	NN
cord-291950-9gtsqyfj	379	36	is	be	VBZ
cord-291950-9gtsqyfj	379	37	no	no	DT
cord-291950-9gtsqyfj	379	38	longer	long	RBR
cord-291950-9gtsqyfj	379	39	appropriate	appropriate	JJ
cord-291950-9gtsqyfj	379	40	.	.	.
cord-291950-9gtsqyfj	380	1	Mammalian	mammalian	JJ
cord-291950-9gtsqyfj	380	2	legumain	legumain	NN
cord-291950-9gtsqyfj	380	3	has	have	VBZ
cord-291950-9gtsqyfj	380	4	been	be	VBN
cord-291950-9gtsqyfj	380	5	characterized	characterize	VBN
cord-291950-9gtsqyfj	380	6	and	and	CC
cord-291950-9gtsqyfj	380	7	shown	show	VBN
cord-291950-9gtsqyfj	380	8	to	to	TO
cord-291950-9gtsqyfj	380	9	be	be	VB
cord-291950-9gtsqyfj	380	10	a	a	DT
cord-291950-9gtsqyfj	380	11	lysosomal	lysosomal	JJ
cord-291950-9gtsqyfj	380	12	enzyme	enzyme	NN
cord-291950-9gtsqyfj	380	13	[	[	-LRB-
cord-291950-9gtsqyfj	380	14	69	69	CD
cord-291950-9gtsqyfj	380	15	]	]	-RRB-
cord-291950-9gtsqyfj	380	16	.	.	.
cord-291950-9gtsqyfj	381	1	Legumain	Legumain	NNP
cord-291950-9gtsqyfj	381	2	is	be	VBZ
cord-291950-9gtsqyfj	381	3	not	not	RB
cord-291950-9gtsqyfj	381	4	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	381	5	by	by	IN
cord-291950-9gtsqyfj	381	6	compound	compound	NN
cord-291950-9gtsqyfj	381	7	E-64	E-64	NNP
cord-291950-9gtsqyfj	381	8	and	and	CC
cord-291950-9gtsqyfj	381	9	like	like	IN
cord-291950-9gtsqyfj	381	10	clostripain	clostripain	NNP
cord-291950-9gtsqyfj	381	11	it	-PRON-	PRP
cord-291950-9gtsqyfj	381	12	reacts	react	VBZ
cord-291950-9gtsqyfj	381	13	more	more	RBR
cord-291950-9gtsqyfj	381	14	rapidly	rapidly	RB
cord-291950-9gtsqyfj	381	15	with	with	IN
cord-291950-9gtsqyfj	381	16	iodoacetamide	iodoacetamide	NN
cord-291950-9gtsqyfj	381	17	than	than	IN
cord-291950-9gtsqyfj	381	18	with	with	IN
cord-291950-9gtsqyfj	381	19	iodoacetate	iodoacetate	NNP
cord-291950-9gtsqyfj	381	20	.	.	.
cord-291950-9gtsqyfj	382	1	The	the	DT
cord-291950-9gtsqyfj	382	2	enzyme	enzyme	NN
cord-291950-9gtsqyfj	382	3	is	be	VBZ
cord-291950-9gtsqyfj	382	4	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	382	5	by	by	IN
cord-291950-9gtsqyfj	382	6	egg	egg	NN
cord-291950-9gtsqyfj	382	7	-	-	HYPH
cord-291950-9gtsqyfj	382	8	white	white	JJ
cord-291950-9gtsqyfj	382	9	cystatin	cystatin	NN
cord-291950-9gtsqyfj	382	10	,	,	,
cord-291950-9gtsqyfj	382	11	which	which	WDT
cord-291950-9gtsqyfj	382	12	is	be	VBZ
cord-291950-9gtsqyfj	382	13	also	also	RB
cord-291950-9gtsqyfj	382	14	an	an	DT
cord-291950-9gtsqyfj	382	15	inhibitor	inhibitor	NN
cord-291950-9gtsqyfj	382	16	of	of	IN
cord-291950-9gtsqyfj	382	17	peptidases	peptidases	NNPS
cord-291950-9gtsqyfj	382	18	in	in	IN
cord-291950-9gtsqyfj	382	19	family	family	NN
cord-291950-9gtsqyfj	382	20	C1	C1	NNP
cord-291950-9gtsqyfj	382	21	(	(	-LRB-
cord-291950-9gtsqyfj	382	22	clan	clan	NN
cord-291950-9gtsqyfj	382	23	CA	CA	NNP
cord-291950-9gtsqyfj	382	24	)	)	-RRB-
cord-291950-9gtsqyfj	382	25	,	,	,
cord-291950-9gtsqyfj	382	26	but	but	CC
cord-291950-9gtsqyfj	382	27	it	-PRON-	PRP
cord-291950-9gtsqyfj	382	28	has	have	VBZ
cord-291950-9gtsqyfj	382	29	been	be	VBN
cord-291950-9gtsqyfj	382	30	found	find	VBN
cord-291950-9gtsqyfj	382	31	that	that	IN
cord-291950-9gtsqyfj	382	32	cystatin	cystatin	NN
cord-291950-9gtsqyfj	382	33	possesses	possess	VBZ
cord-291950-9gtsqyfj	382	34	two	two	CD
cord-291950-9gtsqyfj	382	35	reactive	reactive	JJ
cord-291950-9gtsqyfj	382	36	sites	site	NNS
cord-291950-9gtsqyfj	382	37	,	,	,
cord-291950-9gtsqyfj	382	38	one	one	CD
cord-291950-9gtsqyfj	382	39	for	for	IN
cord-291950-9gtsqyfj	382	40	legumain	legumain	NN
cord-291950-9gtsqyfj	382	41	and	and	CC
cord-291950-9gtsqyfj	382	42	one	one	CD
cord-291950-9gtsqyfj	382	43	for	for	IN
cord-291950-9gtsqyfj	382	44	the	the	DT
cord-291950-9gtsqyfj	382	45	papain	papain	NN
cord-291950-9gtsqyfj	382	46	-	-	HYPH
cord-291950-9gtsqyfj	382	47	like	like	JJ
cord-291950-9gtsqyfj	382	48	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	382	49	,	,	,
cord-291950-9gtsqyfj	382	50	and	and	CC
cord-291950-9gtsqyfj	382	51	is	be	VBZ
cord-291950-9gtsqyfj	382	52	able	able	JJ
cord-291950-9gtsqyfj	382	53	to	to	TO
cord-291950-9gtsqyfj	382	54	inhibit	inhibit	VB
cord-291950-9gtsqyfj	382	55	both	both	DT
cord-291950-9gtsqyfj	382	56	simultaneously	simultaneously	RB
cord-291950-9gtsqyfj	382	57	and	and	CC
cord-291950-9gtsqyfj	382	58	independently	independently	RB
cord-291950-9gtsqyfj	382	59	[	[	-LRB-
cord-291950-9gtsqyfj	382	60	1	1	CD
cord-291950-9gtsqyfj	382	61	]	]	-RRB-
cord-291950-9gtsqyfj	382	62	(	(	-LRB-
cord-291950-9gtsqyfj	382	63	Chapter	chapter	NN
cord-291950-9gtsqyfj	382	64	518	518	CD
cord-291950-9gtsqyfj	382	65	)	)	-RRB-
cord-291950-9gtsqyfj	382	66	.	.	.
cord-291950-9gtsqyfj	383	1	Not	not	RB
cord-291950-9gtsqyfj	383	2	a	a	DT
cord-291950-9gtsqyfj	383	3	conventional	conventional	JJ
cord-291950-9gtsqyfj	383	4	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	383	5	,	,	,
cord-291950-9gtsqyfj	383	6	but	but	CC
cord-291950-9gtsqyfj	383	7	also	also	RB
cord-291950-9gtsqyfj	383	8	in	in	IN
cord-291950-9gtsqyfj	383	9	the	the	DT
cord-291950-9gtsqyfj	383	10	legumain	legumain	NN
cord-291950-9gtsqyfj	383	11	family	family	NN
cord-291950-9gtsqyfj	383	12	,	,	,
cord-291950-9gtsqyfj	383	13	is	be	VBZ
cord-291950-9gtsqyfj	383	14	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NNP
cord-291950-9gtsqyfj	383	15	:	:	:
cord-291950-9gtsqyfj	383	16	protein	protein	NN
cord-291950-9gtsqyfj	383	17	transamidase	transamidase	NNP
cord-291950-9gtsqyfj	383	18	.	.	.
cord-291950-9gtsqyfj	384	1	This	this	DT
cord-291950-9gtsqyfj	384	2	has	have	VBZ
cord-291950-9gtsqyfj	384	3	been	be	VBN
cord-291950-9gtsqyfj	384	4	identified	identify	VBN
cord-291950-9gtsqyfj	384	5	in	in	IN
cord-291950-9gtsqyfj	384	6	Saccharomyces	saccharomyce	NNS
cord-291950-9gtsqyfj	384	7	and	and	CC
cord-291950-9gtsqyfj	384	8	humans	human	NNS
cord-291950-9gtsqyfj	384	9	,	,	,
cord-291950-9gtsqyfj	384	10	and	and	CC
cord-291950-9gtsqyfj	384	11	is	be	VBZ
cord-291950-9gtsqyfj	384	12	responsible	responsible	JJ
cord-291950-9gtsqyfj	384	13	for	for	IN
cord-291950-9gtsqyfj	384	14	attaching	attach	VBG
cord-291950-9gtsqyfj	384	15	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NNP
cord-291950-9gtsqyfj	384	16	(	(	-LRB-
cord-291950-9gtsqyfj	384	17	GPI	GPI	NNP
cord-291950-9gtsqyfj	384	18	)	)	-RRB-
cord-291950-9gtsqyfj	384	19	anchors	anchor	NNS
cord-291950-9gtsqyfj	384	20	to	to	IN
cord-291950-9gtsqyfj	384	21	the	the	DT
cord-291950-9gtsqyfj	384	22	C	C	NNP
cord-291950-9gtsqyfj	384	23	-	-	HYPH
cord-291950-9gtsqyfj	384	24	termini	termini	NNP
cord-291950-9gtsqyfj	384	25	of	of	IN
cord-291950-9gtsqyfj	384	26	newly	newly	RB
cord-291950-9gtsqyfj	384	27	synthesized	synthesize	VBN
cord-291950-9gtsqyfj	384	28	proteins	protein	NNS
cord-291950-9gtsqyfj	384	29	in	in	IN
cord-291950-9gtsqyfj	384	30	the	the	DT
cord-291950-9gtsqyfj	384	31	endoplasmic	endoplasmic	NN
cord-291950-9gtsqyfj	384	32	reticulum	reticulum	NN
cord-291950-9gtsqyfj	384	33	.	.	.
cord-291950-9gtsqyfj	385	1	A	a	DT
cord-291950-9gtsqyfj	385	2	C	c	NN
cord-291950-9gtsqyfj	385	3	-	-	HYPH
cord-291950-9gtsqyfj	385	4	terminal	terminal	NN
cord-291950-9gtsqyfj	385	5	peptide	peptide	NN
cord-291950-9gtsqyfj	385	6	is	be	VBZ
cord-291950-9gtsqyfj	385	7	removed	remove	VBN
cord-291950-9gtsqyfj	385	8	before	before	IN
cord-291950-9gtsqyfj	385	9	the	the	DT
cord-291950-9gtsqyfj	385	10	preformed	preformed	JJ
cord-291950-9gtsqyfj	385	11	GPI	GPI	NNP
cord-291950-9gtsqyfj	385	12	anchor	anchor	NN
cord-291950-9gtsqyfj	385	13	is	be	VBZ
cord-291950-9gtsqyfj	385	14	attached	attach	VBN
cord-291950-9gtsqyfj	385	15	,	,	,
cord-291950-9gtsqyfj	385	16	apparently	apparently	RB
cord-291950-9gtsqyfj	385	17	in	in	IN
cord-291950-9gtsqyfj	385	18	a	a	DT
cord-291950-9gtsqyfj	385	19	single	single	JJ
cord-291950-9gtsqyfj	385	20	reaction	reaction	NN
cord-291950-9gtsqyfj	385	21	.	.	.
cord-291950-9gtsqyfj	386	1	The	the	DT
cord-291950-9gtsqyfj	386	2	transamidase	transamidase	NN
cord-291950-9gtsqyfj	386	3	differs	differ	VBZ
cord-291950-9gtsqyfj	386	4	considerably	considerably	RB
cord-291950-9gtsqyfj	386	5	in	in	IN
cord-291950-9gtsqyfj	386	6	sequence	sequence	NN
cord-291950-9gtsqyfj	386	7	from	from	IN
cord-291950-9gtsqyfj	386	8	the	the	DT
cord-291950-9gtsqyfj	386	9	legumains	legumain	NNS
cord-291950-9gtsqyfj	386	10	,	,	,
cord-291950-9gtsqyfj	386	11	and	and	CC
cord-291950-9gtsqyfj	386	12	the	the	DT
cord-291950-9gtsqyfj	386	13	Cys	Cys	NNP
cord-291950-9gtsqyfj	386	14	residue	residue	NN
cord-291950-9gtsqyfj	386	15	that	that	WDT
cord-291950-9gtsqyfj	386	16	had	have	VBD
cord-291950-9gtsqyfj	386	17	been	be	VBN
cord-291950-9gtsqyfj	386	18	predicted	predict	VBN
cord-291950-9gtsqyfj	386	19	to	to	TO
cord-291950-9gtsqyfj	386	20	be	be	VB
cord-291950-9gtsqyfj	386	21	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	386	22	in	in	IN
cord-291950-9gtsqyfj	386	23	Schistosoma	Schistosoma	NNP
cord-291950-9gtsqyfj	386	24	legumain	legumain	NN
cord-291950-9gtsqyfj	386	25	[	[	-LRB-
cord-291950-9gtsqyfj	386	26	70	70	CD
cord-291950-9gtsqyfj	386	27	]	]	-RRB-
cord-291950-9gtsqyfj	386	28	is	be	VBZ
cord-291950-9gtsqyfj	386	29	replaced	replace	VBN
cord-291950-9gtsqyfj	386	30	by	by	IN
cord-291950-9gtsqyfj	386	31	Leu	Leu	NNP
cord-291950-9gtsqyfj	386	32	.	.	.
cord-291950-9gtsqyfj	387	1	The	the	DT
cord-291950-9gtsqyfj	387	2	evolutionary	evolutionary	JJ
cord-291950-9gtsqyfj	387	3	tree	tree	NN
cord-291950-9gtsqyfj	387	4	demonstrates	demonstrate	VBZ
cord-291950-9gtsqyfj	387	5	the	the	DT
cord-291950-9gtsqyfj	387	6	marked	marked	JJ
cord-291950-9gtsqyfj	387	7	difference	difference	NN
cord-291950-9gtsqyfj	387	8	between	between	IN
cord-291950-9gtsqyfj	387	9	the	the	DT
cord-291950-9gtsqyfj	387	10	forms	form	NNS
cord-291950-9gtsqyfj	387	11	of	of	IN
cord-291950-9gtsqyfj	387	12	legumain	legumain	NN
cord-291950-9gtsqyfj	387	13	and	and	CC
cord-291950-9gtsqyfj	387	14	the	the	DT
cord-291950-9gtsqyfj	387	15	GPI8	GPI8	NNP
cord-291950-9gtsqyfj	387	16	transamidase	transamidase	NN
cord-291950-9gtsqyfj	387	17	(	(	-LRB-
cord-291950-9gtsqyfj	387	18	Chapter	chapter	NN
cord-291950-9gtsqyfj	387	19	520	520	CD
cord-291950-9gtsqyfj	387	20	)	)	-RRB-
cord-291950-9gtsqyfj	387	21	.	.	.
cord-291950-9gtsqyfj	388	1	Members	member	NNS
cord-291950-9gtsqyfj	388	2	of	of	IN
cord-291950-9gtsqyfj	388	3	family	family	NN
cord-291950-9gtsqyfj	388	4	C13	C13	NNP
cord-291950-9gtsqyfj	388	5	are	be	VBP
cord-291950-9gtsqyfj	388	6	known	know	VBN
cord-291950-9gtsqyfj	388	7	principally	principally	RB
cord-291950-9gtsqyfj	388	8	from	from	IN
cord-291950-9gtsqyfj	388	9	animals	animal	NNS
cord-291950-9gtsqyfj	388	10	,	,	,
cord-291950-9gtsqyfj	388	11	plants	plant	NNS
cord-291950-9gtsqyfj	388	12	and	and	CC
cord-291950-9gtsqyfj	388	13	fungi	fungus	NNS
cord-291950-9gtsqyfj	388	14	:	:	:
cord-291950-9gtsqyfj	388	15	the	the	DT
cord-291950-9gtsqyfj	388	16	family	family	NN
cord-291950-9gtsqyfj	388	17	is	be	VBZ
cord-291950-9gtsqyfj	388	18	absent	absent	JJ
cord-291950-9gtsqyfj	388	19	from	from	IN
cord-291950-9gtsqyfj	388	20	the	the	DT
cord-291950-9gtsqyfj	388	21	genome	genome	NN
cord-291950-9gtsqyfj	388	22	of	of	IN
cord-291950-9gtsqyfj	388	23	the	the	DT
cord-291950-9gtsqyfj	388	24	microsporidian	microsporidian	NNP
cord-291950-9gtsqyfj	388	25	Encephalitozoon	Encephalitozoon	NNP
cord-291950-9gtsqyfj	388	26	cuniculi	cuniculi	NNP
cord-291950-9gtsqyfj	388	27	and	and	CC
cord-291950-9gtsqyfj	388	28	not	not	RB
cord-291950-9gtsqyfj	388	29	known	know	VBN
cord-291950-9gtsqyfj	388	30	from	from	IN
cord-291950-9gtsqyfj	388	31	any	any	DT
cord-291950-9gtsqyfj	388	32	other	other	JJ
cord-291950-9gtsqyfj	388	33	protozoa	protozoan	NNS
cord-291950-9gtsqyfj	388	34	.	.	.
cord-291950-9gtsqyfj	389	1	However	however	RB
cord-291950-9gtsqyfj	389	2	,	,	,
cord-291950-9gtsqyfj	389	3	despite	despite	IN
cord-291950-9gtsqyfj	389	4	generally	generally	RB
cord-291950-9gtsqyfj	389	5	being	be	VBG
cord-291950-9gtsqyfj	389	6	absent	absent	JJ
cord-291950-9gtsqyfj	389	7	from	from	IN
cord-291950-9gtsqyfj	389	8	prokaryotes	prokaryote	NNS
cord-291950-9gtsqyfj	389	9	,	,	,
cord-291950-9gtsqyfj	389	10	homologs	homolog	NNS
cord-291950-9gtsqyfj	389	11	are	be	VBP
cord-291950-9gtsqyfj	389	12	present	present	JJ
cord-291950-9gtsqyfj	389	13	in	in	IN
cord-291950-9gtsqyfj	389	14	the	the	DT
cord-291950-9gtsqyfj	389	15	gram	gram	NN
cord-291950-9gtsqyfj	389	16	-	-	HYPH
cord-291950-9gtsqyfj	389	17	negative	negative	JJ
cord-291950-9gtsqyfj	389	18	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	389	19	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	389	20	aeruginosa	aeruginosa	NN
cord-291950-9gtsqyfj	389	21	and	and	CC
cord-291950-9gtsqyfj	389	22	Caulobacter	Caulobacter	NNP
cord-291950-9gtsqyfj	389	23	crescentus	crescentus	NN
cord-291950-9gtsqyfj	389	24	.	.	.
cord-291950-9gtsqyfj	390	1	The	the	DT
cord-291950-9gtsqyfj	390	2	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	390	3	homolog	homolog	NN
cord-291950-9gtsqyfj	390	4	is	be	VBZ
cord-291950-9gtsqyfj	390	5	the	the	DT
cord-291950-9gtsqyfj	390	6	most	most	RBS
cord-291950-9gtsqyfj	390	7	divergent	divergent	JJ
cord-291950-9gtsqyfj	390	8	member	member	NN
cord-291950-9gtsqyfj	390	9	of	of	IN
cord-291950-9gtsqyfj	390	10	the	the	DT
cord-291950-9gtsqyfj	390	11	family	family	NN
cord-291950-9gtsqyfj	390	12	appears	appear	VBZ
cord-291950-9gtsqyfj	390	13	to	to	TO
cord-291950-9gtsqyfj	390	14	be	be	VB
cord-291950-9gtsqyfj	390	15	derived	derive	VBN
cord-291950-9gtsqyfj	390	16	from	from	IN
cord-291950-9gtsqyfj	390	17	a	a	DT
cord-291950-9gtsqyfj	390	18	divergence	divergence	NN
cord-291950-9gtsqyfj	390	19	that	that	WDT
cord-291950-9gtsqyfj	390	20	predates	predate	VBZ
cord-291950-9gtsqyfj	390	21	that	that	DT
cord-291950-9gtsqyfj	390	22	of	of	IN
cord-291950-9gtsqyfj	390	23	legumain	legumain	NN
cord-291950-9gtsqyfj	390	24	and	and	CC
cord-291950-9gtsqyfj	390	25	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NNP
cord-291950-9gtsqyfj	390	26	:	:	:
cord-291950-9gtsqyfj	390	27	protein	protein	NNP
cord-291950-9gtsqyfj	390	28	transamidase	transamidase	NNP
cord-291950-9gtsqyfj	390	29	.	.	.
cord-291950-9gtsqyfj	391	1	Family	Family	NNP
cord-291950-9gtsqyfj	391	2	C11	C11	NNP
cord-291950-9gtsqyfj	391	3	contains	contain	VBZ
cord-291950-9gtsqyfj	391	4	only	only	RB
cord-291950-9gtsqyfj	391	5	clostripain	clostripain	NNP
cord-291950-9gtsqyfj	391	6	(	(	-LRB-
cord-291950-9gtsqyfj	391	7	Chapter	chapter	NN
cord-291950-9gtsqyfj	391	8	521	521	CD
cord-291950-9gtsqyfj	391	9	)	)	-RRB-
cord-291950-9gtsqyfj	391	10	.	.	.
cord-291950-9gtsqyfj	392	1	This	this	DT
cord-291950-9gtsqyfj	392	2	is	be	VBZ
cord-291950-9gtsqyfj	392	3	an	an	DT
cord-291950-9gtsqyfj	392	4	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	392	5	discovered	discover	VBN
cord-291950-9gtsqyfj	392	6	in	in	IN
cord-291950-9gtsqyfj	392	7	Clostridium	Clostridium	NNP
cord-291950-9gtsqyfj	392	8	histolyticum	histolyticum	NN
cord-291950-9gtsqyfj	392	9	that	that	WDT
cord-291950-9gtsqyfj	392	10	has	have	VBZ
cord-291950-9gtsqyfj	392	11	a	a	DT
cord-291950-9gtsqyfj	392	12	preference	preference	NN
cord-291950-9gtsqyfj	392	13	for	for	IN
cord-291950-9gtsqyfj	392	14	hydrolysis	hydrolysis	NN
cord-291950-9gtsqyfj	392	15	of	of	IN
cord-291950-9gtsqyfj	392	16	arginyl	arginyl	NN
cord-291950-9gtsqyfj	392	17	bonds	bond	NNS
cord-291950-9gtsqyfj	392	18	.	.	.
cord-291950-9gtsqyfj	393	1	Clostripain	Clostripain	NNP
cord-291950-9gtsqyfj	393	2	is	be	VBZ
cord-291950-9gtsqyfj	393	3	synthesized	synthesize	VBN
cord-291950-9gtsqyfj	393	4	as	as	IN
cord-291950-9gtsqyfj	393	5	a	a	DT
cord-291950-9gtsqyfj	393	6	proprotein	proprotein	NN
cord-291950-9gtsqyfj	393	7	,	,	,
cord-291950-9gtsqyfj	393	8	and	and	CC
cord-291950-9gtsqyfj	393	9	activation	activation	NN
cord-291950-9gtsqyfj	393	10	requires	require	VBZ
cord-291950-9gtsqyfj	393	11	loss	loss	NN
cord-291950-9gtsqyfj	393	12	of	of	IN
cord-291950-9gtsqyfj	393	13	a	a	DT
cord-291950-9gtsqyfj	393	14	23	23	CD
cord-291950-9gtsqyfj	393	15	residue	residue	NN
cord-291950-9gtsqyfj	393	16	propeptide	propeptide	NN
cord-291950-9gtsqyfj	393	17	and	and	CC
cord-291950-9gtsqyfj	393	18	autolytic	autolytic	JJ
cord-291950-9gtsqyfj	393	19	removal	removal	NN
cord-291950-9gtsqyfj	393	20	of	of	IN
cord-291950-9gtsqyfj	393	21	an	an	DT
cord-291950-9gtsqyfj	393	22	internal	internal	JJ
cord-291950-9gtsqyfj	393	23	nonapeptide	nonapeptide	NN
cord-291950-9gtsqyfj	393	24	to	to	TO
cord-291950-9gtsqyfj	393	25	produce	produce	VB
cord-291950-9gtsqyfj	393	26	a	a	DT
cord-291950-9gtsqyfj	393	27	heterodimer	heterodimer	NN
cord-291950-9gtsqyfj	393	28	consisting	consist	VBG
cord-291950-9gtsqyfj	393	29	of	of	IN
cord-291950-9gtsqyfj	393	30	a	a	DT
cord-291950-9gtsqyfj	393	31	131-residue	131-residue	CD
cord-291950-9gtsqyfj	393	32	light	light	JJ
cord-291950-9gtsqyfj	393	33	chain	chain	NN
cord-291950-9gtsqyfj	393	34	and	and	CC
cord-291950-9gtsqyfj	393	35	a	a	DT
cord-291950-9gtsqyfj	393	36	336-residue	336-residue	CD
cord-291950-9gtsqyfj	393	37	heavy	heavy	JJ
cord-291950-9gtsqyfj	393	38	chain	chain	NN
cord-291950-9gtsqyfj	393	39	that	that	WDT
cord-291950-9gtsqyfj	393	40	contains	contain	VBZ
cord-291950-9gtsqyfj	393	41	the	the	DT
cord-291950-9gtsqyfj	393	42	residues	residue	NNS
cord-291950-9gtsqyfj	393	43	of	of	IN
cord-291950-9gtsqyfj	393	44	the	the	DT
cord-291950-9gtsqyfj	393	45	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	393	46	dyad	dyad	NN
cord-291950-9gtsqyfj	393	47	.	.	.
cord-291950-9gtsqyfj	394	1	Clostripain	Clostripain	NNP
cord-291950-9gtsqyfj	394	2	differs	differ	VBZ
cord-291950-9gtsqyfj	394	3	from	from	IN
cord-291950-9gtsqyfj	394	4	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	394	5	of	of	IN
cord-291950-9gtsqyfj	394	6	the	the	DT
cord-291950-9gtsqyfj	394	7	papain	papain	NN
cord-291950-9gtsqyfj	394	8	family	family	NN
cord-291950-9gtsqyfj	394	9	in	in	IN
cord-291950-9gtsqyfj	394	10	a	a	DT
cord-291950-9gtsqyfj	394	11	number	number	NN
cord-291950-9gtsqyfj	394	12	of	of	IN
cord-291950-9gtsqyfj	394	13	respects	respect	NNS
cord-291950-9gtsqyfj	394	14	:	:	:
cord-291950-9gtsqyfj	395	1	it	-PRON-	PRP
cord-291950-9gtsqyfj	395	2	is	be	VBZ
cord-291950-9gtsqyfj	395	3	calcium	calcium	NN
cord-291950-9gtsqyfj	395	4	dependent	dependent	JJ
cord-291950-9gtsqyfj	395	5	,	,	,
cord-291950-9gtsqyfj	395	6	it	-PRON-	PRP
cord-291950-9gtsqyfj	395	7	is	be	VBZ
cord-291950-9gtsqyfj	395	8	more	more	RBR
cord-291950-9gtsqyfj	395	9	rapidly	rapidly	RB
cord-291950-9gtsqyfj	395	10	inactivated	inactivate	VBN
cord-291950-9gtsqyfj	395	11	by	by	IN
cord-291950-9gtsqyfj	395	12	iodoacetamide	iodoacetamide	NN
cord-291950-9gtsqyfj	395	13	than	than	IN
cord-291950-9gtsqyfj	395	14	by	by	IN
cord-291950-9gtsqyfj	395	15	iodoacetate	iodoacetate	NNP
cord-291950-9gtsqyfj	395	16	,	,	,
cord-291950-9gtsqyfj	395	17	and	and	CC
cord-291950-9gtsqyfj	395	18	E-64	E-64	NNP
cord-291950-9gtsqyfj	395	19	gives	give	VBZ
cord-291950-9gtsqyfj	395	20	only	only	RB
cord-291950-9gtsqyfj	395	21	reversible	reversible	JJ
cord-291950-9gtsqyfj	395	22	inhibition	inhibition	NN
cord-291950-9gtsqyfj	395	23	attributable	attributable	JJ
cord-291950-9gtsqyfj	395	24	to	to	IN
cord-291950-9gtsqyfj	395	25	the	the	DT
cord-291950-9gtsqyfj	395	26	presence	presence	NN
cord-291950-9gtsqyfj	395	27	of	of	IN
cord-291950-9gtsqyfj	395	28	an	an	DT
cord-291950-9gtsqyfj	395	29	arginine	arginine	NN
cord-291950-9gtsqyfj	395	30	-	-	HYPH
cord-291950-9gtsqyfj	395	31	like	like	JJ
cord-291950-9gtsqyfj	395	32	sidechain	sidechain	NN
cord-291950-9gtsqyfj	395	33	in	in	IN
cord-291950-9gtsqyfj	395	34	the	the	DT
cord-291950-9gtsqyfj	395	35	compound	compound	NN
cord-291950-9gtsqyfj	395	36	.	.	.
cord-291950-9gtsqyfj	396	1	Forms	form	NNS
cord-291950-9gtsqyfj	396	2	of	of	IN
cord-291950-9gtsqyfj	396	3	clostripain	clostripain	NNP
cord-291950-9gtsqyfj	396	4	are	be	VBP
cord-291950-9gtsqyfj	396	5	known	know	VBN
cord-291950-9gtsqyfj	396	6	from	from	IN
cord-291950-9gtsqyfj	396	7	Clostridium	clostridium	NN
cord-291950-9gtsqyfj	396	8	perfringens	perfringen	NNS
cord-291950-9gtsqyfj	396	9	and	and	CC
cord-291950-9gtsqyfj	396	10	Thermotoga	thermotoga	JJ
cord-291950-9gtsqyfj	396	11	maritima	maritima	NN
cord-291950-9gtsqyfj	396	12	.	.	.
cord-291950-9gtsqyfj	397	1	Family	Family	NNP
cord-291950-9gtsqyfj	397	2	C25	C25	NNP
cord-291950-9gtsqyfj	397	3	is	be	VBZ
cord-291950-9gtsqyfj	397	4	represented	represent	VBN
cord-291950-9gtsqyfj	397	5	by	by	IN
cord-291950-9gtsqyfj	397	6	gingipains	gingipain	NNS
cord-291950-9gtsqyfj	397	7	R	R	NNP
cord-291950-9gtsqyfj	397	8	and	and	CC
cord-291950-9gtsqyfj	397	9	K	K	NNP
cord-291950-9gtsqyfj	397	10	(	(	-LRB-
cord-291950-9gtsqyfj	397	11	Chapters	chapter	NNS
cord-291950-9gtsqyfj	397	12	522	522	CD
cord-291950-9gtsqyfj	397	13	and	and	CC
cord-291950-9gtsqyfj	397	14	523	523	CD
cord-291950-9gtsqyfj	397	15	)	)	-RRB-
cord-291950-9gtsqyfj	397	16	,	,	,
cord-291950-9gtsqyfj	397	17	secreted	secrete	VBD
cord-291950-9gtsqyfj	397	18	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	397	19	from	from	IN
cord-291950-9gtsqyfj	397	20	the	the	DT
cord-291950-9gtsqyfj	397	21	pathogenic	pathogenic	JJ
cord-291950-9gtsqyfj	397	22	bacterium	bacterium	NN
cord-291950-9gtsqyfj	397	23	Porphyromonas	Porphyromonas	NNP
cord-291950-9gtsqyfj	397	24	gingivalis	gingivalis	NNP
cord-291950-9gtsqyfj	397	25	.	.	.
cord-291950-9gtsqyfj	398	1	Gingipain	Gingipain	NNP
cord-291950-9gtsqyfj	398	2	is	be	VBZ
cord-291950-9gtsqyfj	398	3	a	a	DT
cord-291950-9gtsqyfj	398	4	multidomain	multidomain	NN
cord-291950-9gtsqyfj	398	5	protein	protein	NN
cord-291950-9gtsqyfj	398	6	,	,	,
cord-291950-9gtsqyfj	398	7	containing	contain	VBG
cord-291950-9gtsqyfj	398	8	not	not	RB
cord-291950-9gtsqyfj	398	9	only	only	RB
cord-291950-9gtsqyfj	398	10	a	a	DT
cord-291950-9gtsqyfj	398	11	peptidase	peptidase	NN
cord-291950-9gtsqyfj	398	12	unit	unit	NN
cord-291950-9gtsqyfj	398	13	but	but	CC
cord-291950-9gtsqyfj	398	14	also	also	RB
cord-291950-9gtsqyfj	398	15	a	a	DT
cord-291950-9gtsqyfj	398	16	C	c	NN
cord-291950-9gtsqyfj	398	17	-	-	HYPH
cord-291950-9gtsqyfj	398	18	terminal	terminal	NN
cord-291950-9gtsqyfj	398	19	hemagglutinin	hemagglutinin	NN
cord-291950-9gtsqyfj	398	20	domain	domain	NN
cord-291950-9gtsqyfj	398	21	(	(	-LRB-
cord-291950-9gtsqyfj	398	22	Figure	figure	NN
cord-291950-9gtsqyfj	398	23	404.25	404.25	CD
cord-291950-9gtsqyfj	398	24	)	)	-RRB-
cord-291950-9gtsqyfj	398	25	.	.	.
cord-291950-9gtsqyfj	399	1	Gingipain	Gingipain	NNP
cord-291950-9gtsqyfj	399	2	R	r	NN
cord-291950-9gtsqyfj	399	3	has	have	VBZ
cord-291950-9gtsqyfj	399	4	specificity	specificity	NN
cord-291950-9gtsqyfj	399	5	for	for	IN
cord-291950-9gtsqyfj	399	6	arginyl	arginyl	NN
cord-291950-9gtsqyfj	399	7	bonds	bond	NNS
cord-291950-9gtsqyfj	399	8	,	,	,
cord-291950-9gtsqyfj	399	9	whereas	whereas	IN
cord-291950-9gtsqyfj	399	10	gingipain	gingipain	NNP
cord-291950-9gtsqyfj	399	11	K	K	NNP
cord-291950-9gtsqyfj	399	12	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	399	13	after	after	IN
cord-291950-9gtsqyfj	399	14	lysine	lysine	NN
cord-291950-9gtsqyfj	399	15	residues	residue	NNS
cord-291950-9gtsqyfj	399	16	.	.	.
cord-291950-9gtsqyfj	400	1	Both	both	DT
cord-291950-9gtsqyfj	400	2	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	400	3	are	be	VBP
cord-291950-9gtsqyfj	400	4	thought	think	VBN
cord-291950-9gtsqyfj	400	5	to	to	TO
cord-291950-9gtsqyfj	400	6	contribute	contribute	VB
cord-291950-9gtsqyfj	400	7	to	to	IN
cord-291950-9gtsqyfj	400	8	the	the	DT
cord-291950-9gtsqyfj	400	9	disease	disease	NN
cord-291950-9gtsqyfj	400	10	processes	process	NNS
cord-291950-9gtsqyfj	400	11	in	in	IN
cord-291950-9gtsqyfj	400	12	gingivitis	gingivitis	NN
cord-291950-9gtsqyfj	400	13	.	.	.
cord-291950-9gtsqyfj	401	1	Family	Family	NNP
cord-291950-9gtsqyfj	401	2	C50	C50	NNP
cord-291950-9gtsqyfj	401	3	contains	contain	VBZ
cord-291950-9gtsqyfj	401	4	separase	separase	NN
cord-291950-9gtsqyfj	401	5	(	(	-LRB-
cord-291950-9gtsqyfj	401	6	Chapter	chapter	NN
cord-291950-9gtsqyfj	401	7	524	524	CD
cord-291950-9gtsqyfj	401	8	)	)	-RRB-
cord-291950-9gtsqyfj	401	9	,	,	,
cord-291950-9gtsqyfj	401	10	an	an	DT
cord-291950-9gtsqyfj	401	11	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	401	12	that	that	WDT
cord-291950-9gtsqyfj	401	13	is	be	VBZ
cord-291950-9gtsqyfj	401	14	involved	involve	VBN
cord-291950-9gtsqyfj	401	15	in	in	IN
cord-291950-9gtsqyfj	401	16	the	the	DT
cord-291950-9gtsqyfj	401	17	separation	separation	NN
cord-291950-9gtsqyfj	401	18	of	of	IN
cord-291950-9gtsqyfj	401	19	sister	sister	NN
cord-291950-9gtsqyfj	401	20	chromatids	chromatid	NNS
cord-291950-9gtsqyfj	401	21	during	during	IN
cord-291950-9gtsqyfj	401	22	the	the	DT
cord-291950-9gtsqyfj	401	23	anaphase	anaphase	JJ
cord-291950-9gtsqyfj	401	24	periods	period	NNS
cord-291950-9gtsqyfj	401	25	of	of	IN
cord-291950-9gtsqyfj	401	26	mitosis	mitosis	NN
cord-291950-9gtsqyfj	401	27	or	or	CC
cord-291950-9gtsqyfj	401	28	meiosis	meiosis	NN
cord-291950-9gtsqyfj	401	29	.	.	.
cord-291950-9gtsqyfj	402	1	In	in	IN
cord-291950-9gtsqyfj	402	2	mitosis	mitosis	NN
cord-291950-9gtsqyfj	402	3	,	,	,
cord-291950-9gtsqyfj	402	4	the	the	DT
cord-291950-9gtsqyfj	402	5	chromatids	chromatid	NNS
cord-291950-9gtsqyfj	402	6	are	be	VBP
cord-291950-9gtsqyfj	402	7	bound	bind	VBN
cord-291950-9gtsqyfj	402	8	together	together	RB
cord-291950-9gtsqyfj	402	9	by	by	IN
cord-291950-9gtsqyfj	402	10	the	the	DT
cord-291950-9gtsqyfj	402	11	multi	multi	JJ
cord-291950-9gtsqyfj	402	12	-	-	JJ
cord-291950-9gtsqyfj	402	13	subunit	subunit	JJ
cord-291950-9gtsqyfj	402	14	protein	protein	NN
cord-291950-9gtsqyfj	402	15	cohesin	cohesin	NNS
cord-291950-9gtsqyfj	402	16	,	,	,
cord-291950-9gtsqyfj	402	17	and	and	CC
cord-291950-9gtsqyfj	402	18	cleavage	cleavage	NN
cord-291950-9gtsqyfj	402	19	of	of	IN
cord-291950-9gtsqyfj	402	20	the	the	DT
cord-291950-9gtsqyfj	402	21	Scc1	Scc1	NNP
cord-291950-9gtsqyfj	402	22	subunit	subunit	NN
cord-291950-9gtsqyfj	402	23	of	of	IN
cord-291950-9gtsqyfj	402	24	cohesion	cohesion	NN
cord-291950-9gtsqyfj	402	25	by	by	IN
cord-291950-9gtsqyfj	402	26	separase	separase	NNP
cord-291950-9gtsqyfj	402	27	promotes	promote	VBZ
cord-291950-9gtsqyfj	402	28	chromatid	chromatid	JJ
cord-291950-9gtsqyfj	402	29	separation	separation	NN
cord-291950-9gtsqyfj	402	30	.	.	.
cord-291950-9gtsqyfj	403	1	Cleavage	cleavage	NN
cord-291950-9gtsqyfj	403	2	occurs	occur	VBZ
cord-291950-9gtsqyfj	403	3	at	at	IN
cord-291950-9gtsqyfj	403	4	the	the	DT
cord-291950-9gtsqyfj	403	5	Arg180kArg	Arg180kArg	NNPS
cord-291950-9gtsqyfj	403	6	and	and	CC
cord-291950-9gtsqyfj	403	7	Arg268kArg	Arg268kArg	NNP
cord-291950-9gtsqyfj	403	8	bonds	bond	NNS
cord-291950-9gtsqyfj	403	9	of	of	IN
cord-291950-9gtsqyfj	403	10	the	the	DT
cord-291950-9gtsqyfj	403	11	Scc1	Scc1	NNP
cord-291950-9gtsqyfj	403	12	subunit	subunit	NN
cord-291950-9gtsqyfj	403	13	.	.	.
cord-291950-9gtsqyfj	404	1	Separase	Separase	NNP
cord-291950-9gtsqyfj	404	2	also	also	RB
cord-291950-9gtsqyfj	404	3	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	404	4	the	the	DT
cord-291950-9gtsqyfj	404	5	kinetochore	kinetochore	NN
cord-291950-9gtsqyfj	404	6	-	-	HYPH
cord-291950-9gtsqyfj	404	7	associated	associate	VBN
cord-291950-9gtsqyfj	404	8	protein	protein	NN
cord-291950-9gtsqyfj	404	9	Slk19	Slk19	NNP
cord-291950-9gtsqyfj	404	10	at	at	IN
cord-291950-9gtsqyfj	404	11	the	the	DT
cord-291950-9gtsqyfj	404	12	start	start	NN
cord-291950-9gtsqyfj	404	13	of	of	IN
cord-291950-9gtsqyfj	404	14	anaphase	anaphase	NN
cord-291950-9gtsqyfj	404	15	,	,	,
cord-291950-9gtsqyfj	404	16	which	which	WDT
cord-291950-9gtsqyfj	404	17	is	be	VBZ
cord-291950-9gtsqyfj	404	18	necessary	necessary	JJ
cord-291950-9gtsqyfj	404	19	for	for	IN
cord-291950-9gtsqyfj	404	20	the	the	DT
cord-291950-9gtsqyfj	404	21	development	development	NN
cord-291950-9gtsqyfj	404	22	of	of	IN
cord-291950-9gtsqyfj	404	23	a	a	DT
cord-291950-9gtsqyfj	404	24	stable	stable	JJ
cord-291950-9gtsqyfj	404	25	spindle	spindle	NN
cord-291950-9gtsqyfj	404	26	.	.	.
cord-291950-9gtsqyfj	405	1	In	in	IN
cord-291950-9gtsqyfj	405	2	meiosis	meiosis	NN
cord-291950-9gtsqyfj	405	3	,	,	,
cord-291950-9gtsqyfj	405	4	the	the	DT
cord-291950-9gtsqyfj	405	5	Rec8	Rec8	NNP
cord-291950-9gtsqyfj	405	6	protein	protein	NN
cord-291950-9gtsqyfj	405	7	performs	perform	VBZ
cord-291950-9gtsqyfj	405	8	the	the	DT
cord-291950-9gtsqyfj	405	9	same	same	JJ
cord-291950-9gtsqyfj	405	10	role	role	NN
cord-291950-9gtsqyfj	405	11	as	as	IN
cord-291950-9gtsqyfj	405	12	cohesin	cohesin	NNP
cord-291950-9gtsqyfj	405	13	and	and	CC
cord-291950-9gtsqyfj	405	14	is	be	VBZ
cord-291950-9gtsqyfj	405	15	also	also	RB
cord-291950-9gtsqyfj	405	16	susceptible	susceptible	JJ
cord-291950-9gtsqyfj	405	17	to	to	IN
cord-291950-9gtsqyfj	405	18	cleavage	cleavage	NN
cord-291950-9gtsqyfj	405	19	by	by	IN
cord-291950-9gtsqyfj	405	20	separase	separase	NNP
cord-291950-9gtsqyfj	405	21	.	.	.
cord-291950-9gtsqyfj	406	1	A	a	DT
cord-291950-9gtsqyfj	406	2	simple	simple	JJ
cord-291950-9gtsqyfj	406	3	consensus	consensus	NN
cord-291950-9gtsqyfj	406	4	for	for	IN
cord-291950-9gtsqyfj	406	5	cleavage	cleavage	NN
cord-291950-9gtsqyfj	406	6	is	be	VBZ
cord-291950-9gtsqyfj	406	7	an	an	DT
cord-291950-9gtsqyfj	406	8	acidic	acidic	JJ
cord-291950-9gtsqyfj	406	9	residue	residue	NN
cord-291950-9gtsqyfj	406	10	at	at	IN
cord-291950-9gtsqyfj	406	11	P4	P4	NNP
cord-291950-9gtsqyfj	406	12	,	,	,
cord-291950-9gtsqyfj	406	13	Gly	Gly	NNP
cord-291950-9gtsqyfj	406	14	in	in	IN
cord-291950-9gtsqyfj	406	15	P2	P2	NNP
cord-291950-9gtsqyfj	406	16	,	,	,
cord-291950-9gtsqyfj	406	17	Arg	Arg	NNP
cord-291950-9gtsqyfj	406	18	in	in	IN
cord-291950-9gtsqyfj	406	19	P1	P1	NNP
cord-291950-9gtsqyfj	406	20	and	and	CC
cord-291950-9gtsqyfj	406	21	Arg	Arg	NNP
cord-291950-9gtsqyfj	406	22	,	,	,
cord-291950-9gtsqyfj	406	23	Lys	Lys	NNP
cord-291950-9gtsqyfj	406	24	or	or	CC
cord-291950-9gtsqyfj	406	25	Ser	Ser	NNP
cord-291950-9gtsqyfj	406	26	in	in	IN
cord-291950-9gtsqyfj	406	27	P1	P1	NNP
cord-291950-9gtsqyfj	406	28	0	0	CD
cord-291950-9gtsqyfj	406	29	.	.	.
cord-291950-9gtsqyfj	407	1	Members	member	NNS
cord-291950-9gtsqyfj	407	2	of	of	IN
cord-291950-9gtsqyfj	407	3	family	family	NN
cord-291950-9gtsqyfj	407	4	C50	C50	NNP
cord-291950-9gtsqyfj	407	5	are	be	VBP
cord-291950-9gtsqyfj	407	6	known	know	VBN
cord-291950-9gtsqyfj	407	7	only	only	RB
cord-291950-9gtsqyfj	407	8	from	from	IN
cord-291950-9gtsqyfj	407	9	eukaryotes	eukaryote	NNS
cord-291950-9gtsqyfj	407	10	,	,	,
cord-291950-9gtsqyfj	407	11	and	and	CC
cord-291950-9gtsqyfj	407	12	are	be	VBP
cord-291950-9gtsqyfj	407	13	found	find	VBN
cord-291950-9gtsqyfj	407	14	in	in	IN
cord-291950-9gtsqyfj	407	15	every	every	DT
cord-291950-9gtsqyfj	407	16	eukaryote	eukaryote	NN
cord-291950-9gtsqyfj	407	17	genome	genome	NN
cord-291950-9gtsqyfj	407	18	that	that	WDT
cord-291950-9gtsqyfj	407	19	has	have	VBZ
cord-291950-9gtsqyfj	407	20	so	so	RB
cord-291950-9gtsqyfj	407	21	far	far	RB
cord-291950-9gtsqyfj	407	22	been	be	VBN
cord-291950-9gtsqyfj	407	23	completely	completely	RB
cord-291950-9gtsqyfj	407	24	sequenced	sequence	VBN
cord-291950-9gtsqyfj	407	25	.	.	.
cord-291950-9gtsqyfj	408	1	Family	family	NN
cord-291950-9gtsqyfj	408	2	C80	C80	NNP
cord-291950-9gtsqyfj	408	3	contains	contain	VBZ
cord-291950-9gtsqyfj	408	4	self	self	NN
cord-291950-9gtsqyfj	408	5	-	-	HYPH
cord-291950-9gtsqyfj	408	6	cleaving	cleave	VBG
cord-291950-9gtsqyfj	408	7	proteins	protein	NNS
cord-291950-9gtsqyfj	408	8	that	that	WDT
cord-291950-9gtsqyfj	408	9	are	be	VBP
cord-291950-9gtsqyfj	408	10	precursors	precursor	NNS
cord-291950-9gtsqyfj	408	11	of	of	IN
cord-291950-9gtsqyfj	408	12	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	408	13	toxins	toxin	NNS
cord-291950-9gtsqyfj	408	14	,	,	,
cord-291950-9gtsqyfj	408	15	including	include	VBG
cord-291950-9gtsqyfj	408	16	Vibrio	Vibrio	NNP
cord-291950-9gtsqyfj	408	17	cholera	cholera	NN
cord-291950-9gtsqyfj	408	18	RTX	rtx	NN
cord-291950-9gtsqyfj	408	19	toxin	toxin	NN
cord-291950-9gtsqyfj	408	20	(	(	-LRB-
cord-291950-9gtsqyfj	408	21	Chapter	chapter	NN
cord-291950-9gtsqyfj	408	22	525	525	CD
cord-291950-9gtsqyfj	408	23	)	)	-RRB-
cord-291950-9gtsqyfj	408	24	,	,	,
cord-291950-9gtsqyfj	408	25	and	and	CC
cord-291950-9gtsqyfj	408	26	Clostridium	clostridium	NN
cord-291950-9gtsqyfj	408	27	difficile	difficile	NN
cord-291950-9gtsqyfj	408	28	toxins	toxin	VBZ
cord-291950-9gtsqyfj	408	29	A	A	NNP
cord-291950-9gtsqyfj	408	30	and	and	CC
cord-291950-9gtsqyfj	408	31	B.	B.	NNP
cord-291950-9gtsqyfj	409	1	However	however	RB
cord-291950-9gtsqyfj	409	2	,	,	,
cord-291950-9gtsqyfj	409	3	peptidase	peptidase	NN
cord-291950-9gtsqyfj	409	4	activity	activity	NN
cord-291950-9gtsqyfj	409	5	is	be	VBZ
cord-291950-9gtsqyfj	409	6	not	not	RB
cord-291950-9gtsqyfj	409	7	restricted	restrict	VBN
cord-291950-9gtsqyfj	409	8	to	to	IN
cord-291950-9gtsqyfj	409	9	self	self	NN
cord-291950-9gtsqyfj	409	10	-	-	HYPH
cord-291950-9gtsqyfj	409	11	cleavage	cleavage	NN
cord-291950-9gtsqyfj	409	12	and	and	CC
cord-291950-9gtsqyfj	409	13	the	the	DT
cord-291950-9gtsqyfj	409	14	mature	mature	JJ
cord-291950-9gtsqyfj	409	15	RTX	rtx	NN
cord-291950-9gtsqyfj	409	16	toxin	toxin	NN
cord-291950-9gtsqyfj	409	17	has	have	VBZ
cord-291950-9gtsqyfj	409	18	been	be	VBN
cord-291950-9gtsqyfj	409	19	shown	show	VBN
cord-291950-9gtsqyfj	409	20	to	to	TO
cord-291950-9gtsqyfj	409	21	degrade	degrade	VB
cord-291950-9gtsqyfj	409	22	the	the	DT
cord-291950-9gtsqyfj	409	23	leucine	leucine	NN
cord-291950-9gtsqyfj	409	24	-	-	HYPH
cord-291950-9gtsqyfj	409	25	rich	rich	JJ
cord-291950-9gtsqyfj	409	26	protein	protein	NN
cord-291950-9gtsqyfj	409	27	YopM	YopM	NNP
cord-291950-9gtsqyfj	409	28	[	[	-LRB-
cord-291950-9gtsqyfj	409	29	71	71	CD
cord-291950-9gtsqyfj	409	30	]	]	-RRB-
cord-291950-9gtsqyfj	409	31	.	.	.
cord-291950-9gtsqyfj	410	1	The	the	DT
cord-291950-9gtsqyfj	410	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	410	3	structure	structure	NN
cord-291950-9gtsqyfj	410	4	of	of	IN
cord-291950-9gtsqyfj	410	5	the	the	DT
cord-291950-9gtsqyfj	410	6	cholera	cholera	NN
cord-291950-9gtsqyfj	410	7	RTX	rtx	NN
cord-291950-9gtsqyfj	410	8	toxin	toxin	NN
cord-291950-9gtsqyfj	410	9	has	have	VBZ
cord-291950-9gtsqyfj	410	10	been	be	VBN
cord-291950-9gtsqyfj	410	11	solved	solve	VBN
cord-291950-9gtsqyfj	410	12	[	[	-LRB-
cord-291950-9gtsqyfj	410	13	72	72	CD
cord-291950-9gtsqyfj	410	14	]	]	-RRB-
cord-291950-9gtsqyfj	410	15	and	and	CC
cord-291950-9gtsqyfj	410	16	shows	show	VBZ
cord-291950-9gtsqyfj	410	17	a	a	DT
cord-291950-9gtsqyfj	410	18	structure	structure	NN
cord-291950-9gtsqyfj	410	19	similar	similar	JJ
cord-291950-9gtsqyfj	410	20	to	to	IN
cord-291950-9gtsqyfj	410	21	that	that	DT
cord-291950-9gtsqyfj	410	22	of	of	IN
cord-291950-9gtsqyfj	410	23	caspase-1	caspase-1	NNP
cord-291950-9gtsqyfj	410	24	(	(	-LRB-
cord-291950-9gtsqyfj	410	25	see	see	VB
cord-291950-9gtsqyfj	410	26	Figure	figure	NN
cord-291950-9gtsqyfj	410	27	404	404	CD
cord-291950-9gtsqyfj	410	28	.26	.26	NFP
cord-291950-9gtsqyfj	410	29	)	)	-RRB-
cord-291950-9gtsqyfj	410	30	.	.	.
cord-291950-9gtsqyfj	411	1	Family	family	NN
cord-291950-9gtsqyfj	411	2	C80	C80	NNP
cord-291950-9gtsqyfj	411	3	is	be	VBZ
cord-291950-9gtsqyfj	411	4	therefore	therefore	RB
cord-291950-9gtsqyfj	411	5	included	include	VBN
cord-291950-9gtsqyfj	411	6	in	in	IN
cord-291950-9gtsqyfj	411	7	clan	clan	NN
cord-291950-9gtsqyfj	411	8	CD	cd	NN
cord-291950-9gtsqyfj	411	9	.	.	.
cord-291950-9gtsqyfj	412	1	The	the	DT
cord-291950-9gtsqyfj	412	2	PrtH	PrtH	NNP
cord-291950-9gtsqyfj	412	3	protein	protein	NN
cord-291950-9gtsqyfj	412	4	,	,	,
cord-291950-9gtsqyfj	412	5	a	a	DT
cord-291950-9gtsqyfj	412	6	virulence	virulence	NN
cord-291950-9gtsqyfj	412	7	factor	factor	NN
cord-291950-9gtsqyfj	412	8	from	from	IN
cord-291950-9gtsqyfj	412	9	Tannerella	Tannerella	NNP
cord-291950-9gtsqyfj	412	10	(	(	-LRB-
cord-291950-9gtsqyfj	412	11	formerly	formerly	RB
cord-291950-9gtsqyfj	412	12	Bacteroides	Bacteroides	NNP
cord-291950-9gtsqyfj	412	13	)	)	-RRB-
cord-291950-9gtsqyfj	412	14	forsythensis	forsythensis	NN
cord-291950-9gtsqyfj	412	15	,	,	,
cord-291950-9gtsqyfj	412	16	is	be	VBZ
cord-291950-9gtsqyfj	412	17	the	the	DT
cord-291950-9gtsqyfj	412	18	only	only	RB
cord-291950-9gtsqyfj	412	19	characterized	characterize	VBN
cord-291950-9gtsqyfj	412	20	peptidase	peptidase	NN
cord-291950-9gtsqyfj	412	21	in	in	IN
cord-291950-9gtsqyfj	412	22	family	family	NN
cord-291950-9gtsqyfj	412	23	C84	C84	NNP
cord-291950-9gtsqyfj	412	24	.	.	.
cord-291950-9gtsqyfj	413	1	However	however	RB
cord-291950-9gtsqyfj	413	2	,	,	,
cord-291950-9gtsqyfj	413	3	very	very	RB
cord-291950-9gtsqyfj	413	4	little	little	JJ
cord-291950-9gtsqyfj	413	5	is	be	VBZ
cord-291950-9gtsqyfj	413	6	known	know	VBN
cord-291950-9gtsqyfj	413	7	about	about	IN
cord-291950-9gtsqyfj	413	8	PrtH	PrtH	NNP
cord-291950-9gtsqyfj	413	9	,	,	,
cord-291950-9gtsqyfj	413	10	except	except	IN
cord-291950-9gtsqyfj	413	11	that	that	IN
cord-291950-9gtsqyfj	413	12	it	-PRON-	PRP
cord-291950-9gtsqyfj	413	13	hydrolyzes	hydrolyze	VBZ
cord-291950-9gtsqyfj	413	14	Bz	Bz	NNP
cord-291950-9gtsqyfj	413	15	-	-	HYPH
cord-291950-9gtsqyfj	413	16	Val	Val	NNP
cord-291950-9gtsqyfj	413	17	-	-	HYPH
cord-291950-9gtsqyfj	413	18	Gly	Gly	NNP
cord-291950-9gtsqyfj	413	19	-	-	HYPH
cord-291950-9gtsqyfj	413	20	Arg	arg	NN
cord-291950-9gtsqyfj	413	21	-	-	HYPH
cord-291950-9gtsqyfj	413	22	p	p	NN
cord-291950-9gtsqyfj	413	23	-	-	HYPH
cord-291950-9gtsqyfj	413	24	nitroanilide	nitroanilide	NN
cord-291950-9gtsqyfj	413	25	,	,	,
cord-291950-9gtsqyfj	413	26	which	which	WDT
cord-291950-9gtsqyfj	413	27	can	can	MD
cord-291950-9gtsqyfj	413	28	be	be	VB
cord-291950-9gtsqyfj	413	29	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	413	30	by	by	IN
cord-291950-9gtsqyfj	413	31	standard	standard	JJ
cord-291950-9gtsqyfj	413	32	cysteine	cysteine	NN
cord-291950-9gtsqyfj	413	33	peptidase	peptidase	NN
cord-291950-9gtsqyfj	413	34	inhibitors	inhibitor	NNS
cord-291950-9gtsqyfj	413	35	and	and	CC
cord-291950-9gtsqyfj	413	36	the	the	DT
cord-291950-9gtsqyfj	413	37	metal	metal	NN
cord-291950-9gtsqyfj	413	38	chelator	chelator	NN
cord-291950-9gtsqyfj	413	39	EDTA	EDTA	NNP
cord-291950-9gtsqyfj	413	40	[	[	-LRB-
cord-291950-9gtsqyfj	413	41	73	73	CD
cord-291950-9gtsqyfj	413	42	]	]	-RRB-
cord-291950-9gtsqyfj	413	43	.	.	.
cord-291950-9gtsqyfj	414	1	The	the	DT
cord-291950-9gtsqyfj	414	2	prtH	prth	CD
cord-291950-9gtsqyfj	414	3	gene	gene	NN
cord-291950-9gtsqyfj	414	4	is	be	VBZ
cord-291950-9gtsqyfj	414	5	associated	associate	VBN
cord-291950-9gtsqyfj	414	6	with	with	IN
cord-291950-9gtsqyfj	414	7	the	the	DT
cord-291950-9gtsqyfj	414	8	transition	transition	NN
cord-291950-9gtsqyfj	414	9	from	from	IN
cord-291950-9gtsqyfj	414	10	a	a	DT
cord-291950-9gtsqyfj	414	11	commensal	commensal	NN
cord-291950-9gtsqyfj	414	12	to	to	IN
cord-291950-9gtsqyfj	414	13	pathogenic	pathogenic	JJ
cord-291950-9gtsqyfj	414	14	organism	organism	NN
cord-291950-9gtsqyfj	414	15	,	,	,
cord-291950-9gtsqyfj	414	16	and	and	CC
cord-291950-9gtsqyfj	414	17	increased	increase	VBN
cord-291950-9gtsqyfj	414	18	levels	level	NNS
cord-291950-9gtsqyfj	414	19	are	be	VBP
cord-291950-9gtsqyfj	414	20	associated	associate	VBN
cord-291950-9gtsqyfj	414	21	with	with	IN
cord-291950-9gtsqyfj	414	22	release	release	NN
cord-291950-9gtsqyfj	414	23	of	of	IN
cord-291950-9gtsqyfj	414	24	cells	cell	NNS
cord-291950-9gtsqyfj	414	25	from	from	IN
cord-291950-9gtsqyfj	414	26	the	the	DT
cord-291950-9gtsqyfj	414	27	substratum	substratum	NN
cord-291950-9gtsqyfj	414	28	[	[	-LRB-
cord-291950-9gtsqyfj	414	29	74	74	CD
cord-291950-9gtsqyfj	414	30	]	]	-RRB-
cord-291950-9gtsqyfj	414	31	.	.	.
cord-291950-9gtsqyfj	415	1	Although	although	IN
cord-291950-9gtsqyfj	415	2	there	there	EX
cord-291950-9gtsqyfj	415	3	is	be	VBZ
cord-291950-9gtsqyfj	415	4	no	no	DT
cord-291950-9gtsqyfj	415	5	information	information	NN
cord-291950-9gtsqyfj	415	6	about	about	IN
cord-291950-9gtsqyfj	415	7	structure	structure	NN
cord-291950-9gtsqyfj	415	8	or	or	CC
cord-291950-9gtsqyfj	415	9	active	active	JJ
cord-291950-9gtsqyfj	415	10	site	site	NN
cord-291950-9gtsqyfj	415	11	residues	residue	NNS
cord-291950-9gtsqyfj	415	12	,	,	,
cord-291950-9gtsqyfj	415	13	a	a	DT
cord-291950-9gtsqyfj	415	14	caspases	caspases	NN
cord-291950-9gtsqyfj	415	15	-	-	HYPH
cord-291950-9gtsqyfj	415	16	like	like	JJ
cord-291950-9gtsqyfj	415	17	structure	structure	NN
cord-291950-9gtsqyfj	415	18	has	have	VBZ
cord-291950-9gtsqyfj	415	19	been	be	VBN
cord-291950-9gtsqyfj	415	20	predicted	predict	VBN
cord-291950-9gtsqyfj	415	21	along	along	IN
cord-291950-9gtsqyfj	415	22	with	with	IN
cord-291950-9gtsqyfj	415	23	a	a	DT
cord-291950-9gtsqyfj	415	24	His	His	NNP
cord-291950-9gtsqyfj	415	25	,	,	,
cord-291950-9gtsqyfj	415	26	Cys	Cys	NNP
cord-291950-9gtsqyfj	415	27	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	415	28	dyad	dyad	NN
cord-291950-9gtsqyfj	415	29	.	.	.
cord-291950-9gtsqyfj	416	1	The	the	DT
cord-291950-9gtsqyfj	416	2	His	His	NNP
cord-291950-9gtsqyfj	416	3	and	and	CC
cord-291950-9gtsqyfj	416	4	Cys	Cys	NNP
cord-291950-9gtsqyfj	416	5	residues	residue	NNS
cord-291950-9gtsqyfj	416	6	occur	occur	VBP
cord-291950-9gtsqyfj	416	7	in	in	IN
cord-291950-9gtsqyfj	416	8	motifs	motif	NNS
cord-291950-9gtsqyfj	416	9	similar	similar	JJ
cord-291950-9gtsqyfj	416	10	to	to	IN
cord-291950-9gtsqyfj	416	11	those	those	DT
cord-291950-9gtsqyfj	416	12	around	around	IN
cord-291950-9gtsqyfj	416	13	the	the	DT
cord-291950-9gtsqyfj	416	14	active	active	JJ
cord-291950-9gtsqyfj	416	15	site	site	NN
cord-291950-9gtsqyfj	416	16	residues	residue	NNS
cord-291950-9gtsqyfj	416	17	of	of	IN
cord-291950-9gtsqyfj	416	18	caspases	caspase	NNS
cord-291950-9gtsqyfj	416	19	and	and	CC
cord-291950-9gtsqyfj	416	20	legumains	legumain	NNS
cord-291950-9gtsqyfj	416	21	[	[	-LRB-
cord-291950-9gtsqyfj	416	22	75	75	CD
cord-291950-9gtsqyfj	416	23	]	]	-RRB-
cord-291950-9gtsqyfj	416	24	.	.	.
cord-291950-9gtsqyfj	417	1	Clan	Clan	NNP
cord-291950-9gtsqyfj	417	2	CE	CE	NNP
cord-291950-9gtsqyfj	417	3	contains	contain	VBZ
cord-291950-9gtsqyfj	417	4	four	four	CD
cord-291950-9gtsqyfj	417	5	families	family	NNS
cord-291950-9gtsqyfj	417	6	:	:	:
cord-291950-9gtsqyfj	417	7	C5	C5	NNP
cord-291950-9gtsqyfj	417	8	,	,	,
cord-291950-9gtsqyfj	417	9	C48	C48	NNP
cord-291950-9gtsqyfj	417	10	,	,	,
cord-291950-9gtsqyfj	417	11	C55	C55	NNP
cord-291950-9gtsqyfj	417	12	and	and	CC
cord-291950-9gtsqyfj	417	13	C57	C57	NNP
cord-291950-9gtsqyfj	417	14	.	.	.
cord-291950-9gtsqyfj	418	1	Three	three	CD
cord-291950-9gtsqyfj	418	2	-	-	HYPH
cord-291950-9gtsqyfj	418	3	dimensional	dimensional	JJ
cord-291950-9gtsqyfj	418	4	structures	structure	NNS
cord-291950-9gtsqyfj	418	5	have	have	VBP
cord-291950-9gtsqyfj	418	6	been	be	VBN
cord-291950-9gtsqyfj	418	7	solved	solve	VBN
cord-291950-9gtsqyfj	418	8	for	for	IN
cord-291950-9gtsqyfj	418	9	adenain	adenain	NNP
cord-291950-9gtsqyfj	418	10	(	(	-LRB-
cord-291950-9gtsqyfj	418	11	Chapter	chapter	NN
cord-291950-9gtsqyfj	418	12	526	526	CD
cord-291950-9gtsqyfj	418	13	)	)	-RRB-
cord-291950-9gtsqyfj	418	14	in	in	IN
cord-291950-9gtsqyfj	418	15	family	family	NN
cord-291950-9gtsqyfj	418	16	C5	C5	NNP
cord-291950-9gtsqyfj	418	17	and	and	CC
cord-291950-9gtsqyfj	418	18	the	the	DT
cord-291950-9gtsqyfj	418	19	Ulp1	Ulp1	NNP
cord-291950-9gtsqyfj	418	20	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	418	21	(	(	-LRB-
cord-291950-9gtsqyfj	418	22	Chapter	chapter	NN
cord-291950-9gtsqyfj	418	23	527	527	CD
cord-291950-9gtsqyfj	418	24	)	)	-RRB-
cord-291950-9gtsqyfj	418	25	in	in	IN
cord-291950-9gtsqyfj	418	26	family	family	NN
cord-291950-9gtsqyfj	418	27	C48	C48	NNP
cord-291950-9gtsqyfj	418	28	.	.	.
cord-291950-9gtsqyfj	419	1	The	the	DT
cord-291950-9gtsqyfj	419	2	families	family	NNS
cord-291950-9gtsqyfj	419	3	C55	C55	NNP
cord-291950-9gtsqyfj	419	4	,	,	,
cord-291950-9gtsqyfj	419	5	containing	contain	VBG
cord-291950-9gtsqyfj	419	6	the	the	DT
cord-291950-9gtsqyfj	419	7	YopJ	YopJ	NNP
cord-291950-9gtsqyfj	419	8	protease	protease	NN
cord-291950-9gtsqyfj	419	9	from	from	IN
cord-291950-9gtsqyfj	419	10	Yersinia	Yersinia	NNP
cord-291950-9gtsqyfj	419	11	,	,	,
cord-291950-9gtsqyfj	419	12	and	and	CC
cord-291950-9gtsqyfj	419	13	C57	C57	NNP
cord-291950-9gtsqyfj	419	14	,	,	,
cord-291950-9gtsqyfj	419	15	containing	contain	VBG
cord-291950-9gtsqyfj	419	16	the	the	DT
cord-291950-9gtsqyfj	419	17	vaccinia	vaccinia	NN
cord-291950-9gtsqyfj	419	18	virus	virus	NN
cord-291950-9gtsqyfj	419	19	I7	I7	NNP
cord-291950-9gtsqyfj	419	20	protein	protein	NN
cord-291950-9gtsqyfj	419	21	,	,	,
cord-291950-9gtsqyfj	419	22	are	be	VBP
cord-291950-9gtsqyfj	419	23	included	include	VBN
cord-291950-9gtsqyfj	419	24	in	in	IN
cord-291950-9gtsqyfj	419	25	clan	clan	NN
cord-291950-9gtsqyfj	419	26	CE	CE	NNP
cord-291950-9gtsqyfj	419	27	because	because	IN
cord-291950-9gtsqyfj	419	28	the	the	DT
cord-291950-9gtsqyfj	419	29	order	order	NN
cord-291950-9gtsqyfj	419	30	of	of	IN
cord-291950-9gtsqyfj	419	31	putative	putative	JJ
cord-291950-9gtsqyfj	419	32	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	419	33	residues	residue	NNS
cord-291950-9gtsqyfj	419	34	(	(	-LRB-
cord-291950-9gtsqyfj	419	35	His	-PRON-	PRP$
cord-291950-9gtsqyfj	419	36	,	,	,
cord-291950-9gtsqyfj	419	37	Glu	Glu	NNP
cord-291950-9gtsqyfj	419	38	or	or	CC
cord-291950-9gtsqyfj	419	39	Asp	Asp	NNP
cord-291950-9gtsqyfj	419	40	,	,	,
cord-291950-9gtsqyfj	419	41	Gln	Gln	NNP
cord-291950-9gtsqyfj	419	42	,	,	,
cord-291950-9gtsqyfj	419	43	Cys	Cys	NNP
cord-291950-9gtsqyfj	419	44	)	)	-RRB-
cord-291950-9gtsqyfj	419	45	is	be	VBZ
cord-291950-9gtsqyfj	419	46	the	the	DT
cord-291950-9gtsqyfj	419	47	same	same	JJ
cord-291950-9gtsqyfj	419	48	in	in	IN
cord-291950-9gtsqyfj	419	49	each	each	DT
cord-291950-9gtsqyfj	419	50	.	.	.
cord-291950-9gtsqyfj	420	1	Several	several	JJ
cord-291950-9gtsqyfj	420	2	of	of	IN
cord-291950-9gtsqyfj	420	3	the	the	DT
cord-291950-9gtsqyfj	420	4	peptidases	peptidases	NNPS
cord-291950-9gtsqyfj	420	5	in	in	IN
cord-291950-9gtsqyfj	420	6	clan	clan	NN
cord-291950-9gtsqyfj	420	7	CE	CE	NNP
cord-291950-9gtsqyfj	420	8	show	show	VBP
cord-291950-9gtsqyfj	420	9	specificity	specificity	NN
cord-291950-9gtsqyfj	420	10	for	for	IN
cord-291950-9gtsqyfj	420	11	cleavage	cleavage	NN
cord-291950-9gtsqyfj	420	12	in	in	IN
cord-291950-9gtsqyfj	420	13	the	the	DT
cord-291950-9gtsqyfj	420	14	Gly	Gly	NNP
cord-291950-9gtsqyfj	420	15	-	-	HYPH
cord-291950-9gtsqyfj	420	16	GlykXaa	GlykXaa	NNP
cord-291950-9gtsqyfj	420	17	motif	motif	NN
cord-291950-9gtsqyfj	420	18	.	.	.
cord-291950-9gtsqyfj	421	1	An	an	DT
cord-291950-9gtsqyfj	421	2	alignment	alignment	NN
cord-291950-9gtsqyfj	421	3	showing	show	VBG
cord-291950-9gtsqyfj	421	4	conservation	conservation	NN
cord-291950-9gtsqyfj	421	5	of	of	IN
cord-291950-9gtsqyfj	421	6	sequence	sequence	NN
cord-291950-9gtsqyfj	421	7	around	around	IN
cord-291950-9gtsqyfj	421	8	the	the	DT
cord-291950-9gtsqyfj	421	9	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	421	10	residues	residue	NNS
cord-291950-9gtsqyfj	421	11	is	be	VBZ
cord-291950-9gtsqyfj	421	12	shown	show	VBN
cord-291950-9gtsqyfj	421	13	in	in	IN
cord-291950-9gtsqyfj	421	14	Figure	Figure	NNP
cord-291950-9gtsqyfj	421	15	404	404	CD
cord-291950-9gtsqyfj	421	16	.27	.27	CD
cord-291950-9gtsqyfj	421	17	,	,	,
cord-291950-9gtsqyfj	421	18	and	and	CC
cord-291950-9gtsqyfj	421	19	secondary	secondary	JJ
cord-291950-9gtsqyfj	421	20	structures	structure	NNS
cord-291950-9gtsqyfj	421	21	are	be	VBP
cord-291950-9gtsqyfj	421	22	compared	compare	VBN
cord-291950-9gtsqyfj	421	23	in	in	IN
cord-291950-9gtsqyfj	421	24	Figure	figure	NN
cord-291950-9gtsqyfj	421	25	404	404	CD
cord-291950-9gtsqyfj	421	26	.	.	.
cord-291950-9gtsqyfj	422	1	28	28	CD
cord-291950-9gtsqyfj	422	2	.	.	.
cord-291950-9gtsqyfj	423	1	Family	Family	NNP
cord-291950-9gtsqyfj	423	2	C5	C5	NNP
cord-291950-9gtsqyfj	423	3	contains	contain	VBZ
cord-291950-9gtsqyfj	423	4	adenain	adenain	NN
cord-291950-9gtsqyfj	423	5	,	,	,
cord-291950-9gtsqyfj	423	6	an	an	DT
cord-291950-9gtsqyfj	423	7	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	423	8	from	from	IN
cord-291950-9gtsqyfj	423	9	adenoviruses	adenovirus	NNS
cord-291950-9gtsqyfj	423	10	.	.	.
cord-291950-9gtsqyfj	424	1	Adenoviruses	adenovirus	NNS
cord-291950-9gtsqyfj	424	2	are	be	VBP
cord-291950-9gtsqyfj	424	3	double	double	RB
cord-291950-9gtsqyfj	424	4	-	-	HYPH
cord-291950-9gtsqyfj	424	5	stranded	strand	VBN
cord-291950-9gtsqyfj	424	6	DNA	dna	NN
cord-291950-9gtsqyfj	424	7	viruses	virus	NNS
cord-291950-9gtsqyfj	424	8	that	that	WDT
cord-291950-9gtsqyfj	424	9	do	do	VBP
cord-291950-9gtsqyfj	424	10	not	not	RB
cord-291950-9gtsqyfj	424	11	encode	encode	VB
cord-291950-9gtsqyfj	424	12	polyproteins	polyprotein	NNS
cord-291950-9gtsqyfj	424	13	but	but	CC
cord-291950-9gtsqyfj	424	14	have	have	VBP
cord-291950-9gtsqyfj	424	15	a	a	DT
cord-291950-9gtsqyfj	424	16	separate	separate	JJ
cord-291950-9gtsqyfj	424	17	gene	gene	NN
cord-291950-9gtsqyfj	424	18	for	for	IN
cord-291950-9gtsqyfj	424	19	each	each	DT
cord-291950-9gtsqyfj	424	20	protein	protein	NN
cord-291950-9gtsqyfj	424	21	.	.	.
cord-291950-9gtsqyfj	425	1	Activation	activation	NN
cord-291950-9gtsqyfj	425	2	of	of	IN
cord-291950-9gtsqyfj	425	3	the	the	DT
cord-291950-9gtsqyfj	425	4	proteins	protein	NNS
cord-291950-9gtsqyfj	425	5	involves	involve	VBZ
cord-291950-9gtsqyfj	425	6	processing	processing	NN
cord-291950-9gtsqyfj	425	7	at	at	IN
cord-291950-9gtsqyfj	425	8	the	the	DT
cord-291950-9gtsqyfj	425	9	N	n	CD
cord-291950-9gtsqyfj	425	10	-	-	HYPH
cord-291950-9gtsqyfj	425	11	terminus	terminus	NN
cord-291950-9gtsqyfj	425	12	to	to	TO
cord-291950-9gtsqyfj	425	13	remove	remove	VB
cord-291950-9gtsqyfj	425	14	a	a	DT
cord-291950-9gtsqyfj	425	15	propeptide	propeptide	NN
cord-291950-9gtsqyfj	425	16	,	,	,
cord-291950-9gtsqyfj	425	17	and	and	CC
cord-291950-9gtsqyfj	425	18	it	-PRON-	PRP
cord-291950-9gtsqyfj	425	19	is	be	VBZ
cord-291950-9gtsqyfj	425	20	the	the	DT
cord-291950-9gtsqyfj	425	21	adenovirus	adenovirus	NN
cord-291950-9gtsqyfj	425	22	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	425	23	that	that	WDT
cord-291950-9gtsqyfj	425	24	is	be	VBZ
cord-291950-9gtsqyfj	425	25	responsible	responsible	JJ
cord-291950-9gtsqyfj	425	26	for	for	IN
cord-291950-9gtsqyfj	425	27	this	this	DT
cord-291950-9gtsqyfj	425	28	[	[	-LRB-
cord-291950-9gtsqyfj	425	29	76	76	CD
cord-291950-9gtsqyfj	425	30	]	]	-RRB-
cord-291950-9gtsqyfj	425	31	.	.	.
cord-291950-9gtsqyfj	426	1	The	the	DT
cord-291950-9gtsqyfj	426	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	426	3	structure	structure	NN
cord-291950-9gtsqyfj	426	4	of	of	IN
cord-291950-9gtsqyfj	426	5	adenain	adenain	NNP
cord-291950-9gtsqyfj	426	6	from	from	IN
cord-291950-9gtsqyfj	426	7	human	human	JJ
cord-291950-9gtsqyfj	426	8	adenovirus	adenovirus	NN
cord-291950-9gtsqyfj	426	9	type	type	NN
cord-291950-9gtsqyfj	426	10	2	2	CD
cord-291950-9gtsqyfj	427	1	(	(	-LRB-
cord-291950-9gtsqyfj	427	2	Figure	figure	NN
cord-291950-9gtsqyfj	427	3	404	404	CD
cord-291950-9gtsqyfj	427	4	.29	.29	NFP
cord-291950-9gtsqyfj	427	5	)	)	-RRB-
cord-291950-9gtsqyfj	427	6	shows	show	VBZ
cord-291950-9gtsqyfj	428	1	an	an	DT
cord-291950-9gtsqyfj	428	2	α	α	NN
cord-291950-9gtsqyfj	428	3	/	/	SYM
cord-291950-9gtsqyfj	428	4	β	β	NN
cord-291950-9gtsqyfj	428	5	fold	fold	VB
cord-291950-9gtsqyfj	428	6	with	with	IN
cord-291950-9gtsqyfj	428	7	some	some	DT
cord-291950-9gtsqyfj	428	8	remarkable	remarkable	JJ
cord-291950-9gtsqyfj	428	9	similarities	similarity	NNS
cord-291950-9gtsqyfj	428	10	to	to	IN
cord-291950-9gtsqyfj	428	11	that	that	DT
cord-291950-9gtsqyfj	428	12	of	of	IN
cord-291950-9gtsqyfj	428	13	papain	papain	NN
cord-291950-9gtsqyfj	428	14	but	but	CC
cord-291950-9gtsqyfj	428	15	with	with	IN
cord-291950-9gtsqyfj	428	16	the	the	DT
cord-291950-9gtsqyfj	428	17	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	428	18	residues	residue	NNS
cord-291950-9gtsqyfj	428	19	in	in	IN
cord-291950-9gtsqyfj	428	20	the	the	DT
cord-291950-9gtsqyfj	428	21	order	order	NN
cord-291950-9gtsqyfj	428	22	His	-PRON-	PRP$
cord-291950-9gtsqyfj	428	23	,	,	,
cord-291950-9gtsqyfj	428	24	Cys	Cys	NNP
cord-291950-9gtsqyfj	428	25	in	in	IN
cord-291950-9gtsqyfj	428	26	the	the	DT
cord-291950-9gtsqyfj	428	27	sequence	sequence	NN
cord-291950-9gtsqyfj	428	28	.	.	.
cord-291950-9gtsqyfj	429	1	The	the	DT
cord-291950-9gtsqyfj	429	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	429	3	dyad	dyad	NN
cord-291950-9gtsqyfj	429	4	is	be	VBZ
cord-291950-9gtsqyfj	429	5	complemented	complement	VBN
cord-291950-9gtsqyfj	429	6	by	by	IN
cord-291950-9gtsqyfj	429	7	two	two	CD
cord-291950-9gtsqyfj	429	8	other	other	JJ
cord-291950-9gtsqyfj	429	9	residues	residue	NNS
cord-291950-9gtsqyfj	429	10	:	:	:
cord-291950-9gtsqyfj	429	11	Glu71	glu71	UH
cord-291950-9gtsqyfj	429	12	(	(	-LRB-
cord-291950-9gtsqyfj	429	13	most	most	RBS
cord-291950-9gtsqyfj	429	14	commonly	commonly	RB
cord-291950-9gtsqyfj	429	15	Asp	Asp	NNP
cord-291950-9gtsqyfj	429	16	,	,	,
cord-291950-9gtsqyfj	429	17	in	in	IN
cord-291950-9gtsqyfj	429	18	the	the	DT
cord-291950-9gtsqyfj	429	19	clan	clan	NN
cord-291950-9gtsqyfj	429	20	as	as	IN
cord-291950-9gtsqyfj	429	21	a	a	DT
cord-291950-9gtsqyfj	429	22	whole	whole	NN
cord-291950-9gtsqyfj	429	23	;	;	:
cord-291950-9gtsqyfj	429	24	numbering	number	VBG
cord-291950-9gtsqyfj	429	25	as	as	IN
cord-291950-9gtsqyfj	429	26	in	in	IN
cord-291950-9gtsqyfj	429	27	Figure	figure	NN
cord-291950-9gtsqyfj	429	28	404	404	CD
cord-291950-9gtsqyfj	429	29	.28	.28	NFP
cord-291950-9gtsqyfj	429	30	)	)	-RRB-
cord-291950-9gtsqyfj	429	31	,	,	,
cord-291950-9gtsqyfj	429	32	which	which	WDT
cord-291950-9gtsqyfj	429	33	has	have	VBZ
cord-291950-9gtsqyfj	429	34	the	the	DT
cord-291950-9gtsqyfj	429	35	same	same	JJ
cord-291950-9gtsqyfj	429	36	role	role	NN
cord-291950-9gtsqyfj	429	37	of	of	IN
cord-291950-9gtsqyfj	429	38	orientating	orientate	VBG
cord-291950-9gtsqyfj	429	39	the	the	DT
cord-291950-9gtsqyfj	429	40	imidazolium	imidazolium	NN
cord-291950-9gtsqyfj	429	41	ring	ring	NN
cord-291950-9gtsqyfj	429	42	of	of	IN
cord-291950-9gtsqyfj	429	43	the	the	DT
cord-291950-9gtsqyfj	429	44	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	429	45	His54	His54	NNP
cord-291950-9gtsqyfj	429	46	as	as	IN
cord-291950-9gtsqyfj	429	47	does	do	VBZ
cord-291950-9gtsqyfj	429	48	Asn308	Asn308	.
cord-291950-9gtsqyfj	429	49	of	of	IN
cord-291950-9gtsqyfj	429	50	papain	papain	NN
cord-291950-9gtsqyfj	429	51	,	,	,
cord-291950-9gtsqyfj	429	52	and	and	CC
cord-291950-9gtsqyfj	429	53	Gln115	gln115	CD
cord-291950-9gtsqyfj	429	54	,	,	,
cord-291950-9gtsqyfj	429	55	which	which	WDT
cord-291950-9gtsqyfj	429	56	helps	help	VBZ
cord-291950-9gtsqyfj	429	57	form	form	VB
cord-291950-9gtsqyfj	429	58	the	the	DT
cord-291950-9gtsqyfj	429	59	oxyanion	oxyanion	NN
cord-291950-9gtsqyfj	429	60	hole	hole	NN
cord-291950-9gtsqyfj	429	61	,	,	,
cord-291950-9gtsqyfj	429	62	similarly	similarly	RB
cord-291950-9gtsqyfj	429	63	to	to	IN
cord-291950-9gtsqyfj	429	64	Gln152	gln152	CD
cord-291950-9gtsqyfj	429	65	of	of	IN
cord-291950-9gtsqyfj	429	66	papain	papain	NN
cord-291950-9gtsqyfj	429	67	.	.	.
cord-291950-9gtsqyfj	430	1	The	the	DT
cord-291950-9gtsqyfj	430	2	catalytic	catalytic	NN
cord-291950-9gtsqyfj	430	3	Cys122	Cys122	NFP
cord-291950-9gtsqyfj	430	4	is	be	VBZ
cord-291950-9gtsqyfj	430	5	also	also	RB
cord-291950-9gtsqyfj	430	6	positioned	position	VBN
cord-291950-9gtsqyfj	430	7	at	at	IN
cord-291950-9gtsqyfj	430	8	the	the	DT
cord-291950-9gtsqyfj	430	9	start	start	NN
cord-291950-9gtsqyfj	430	10	of	of	IN
cord-291950-9gtsqyfj	430	11	a	a	DT
cord-291950-9gtsqyfj	430	12	long	long	JJ
cord-291950-9gtsqyfj	430	13	helix	helix	NN
cord-291950-9gtsqyfj	430	14	,	,	,
cord-291950-9gtsqyfj	430	15	as	as	IN
cord-291950-9gtsqyfj	430	16	in	in	IN
cord-291950-9gtsqyfj	430	17	papain	papain	NN
cord-291950-9gtsqyfj	430	18	[	[	-LRB-
cord-291950-9gtsqyfj	430	19	77	77	CD
cord-291950-9gtsqyfj	430	20	]	]	-RRB-
cord-291950-9gtsqyfj	430	21	.	.	.
cord-291950-9gtsqyfj	431	1	However	however	RB
cord-291950-9gtsqyfj	431	2	,	,	,
cord-291950-9gtsqyfj	431	3	the	the	DT
cord-291950-9gtsqyfj	431	4	structures	structure	NNS
cord-291950-9gtsqyfj	431	5	are	be	VBP
cord-291950-9gtsqyfj	431	6	so	so	RB
cord-291950-9gtsqyfj	431	7	different	different	JJ
cord-291950-9gtsqyfj	431	8	that	that	IN
cord-291950-9gtsqyfj	431	9	we	-PRON-	PRP
cord-291950-9gtsqyfj	431	10	conclude	conclude	VBP
cord-291950-9gtsqyfj	431	11	that	that	IN
cord-291950-9gtsqyfj	431	12	they	-PRON-	PRP
cord-291950-9gtsqyfj	431	13	have	have	VBP
cord-291950-9gtsqyfj	431	14	resulted	result	VBN
cord-291950-9gtsqyfj	431	15	from	from	IN
cord-291950-9gtsqyfj	431	16	convergent	convergent	JJ
cord-291950-9gtsqyfj	431	17	evolution	evolution	NN
cord-291950-9gtsqyfj	431	18	.	.	.
cord-291950-9gtsqyfj	432	1	The	the	DT
cord-291950-9gtsqyfj	432	2	adenovirus	adenovirus	NN
cord-291950-9gtsqyfj	432	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	432	4	is	be	VBZ
cord-291950-9gtsqyfj	432	5	synthesized	synthesize	VBN
cord-291950-9gtsqyfj	432	6	as	as	IN
cord-291950-9gtsqyfj	432	7	an	an	DT
cord-291950-9gtsqyfj	432	8	active	active	JJ
cord-291950-9gtsqyfj	432	9	enzyme	enzyme	NN
cord-291950-9gtsqyfj	432	10	without	without	IN
cord-291950-9gtsqyfj	432	11	a	a	DT
cord-291950-9gtsqyfj	432	12	propeptide	propeptide	NN
cord-291950-9gtsqyfj	432	13	.	.	.
cord-291950-9gtsqyfj	433	1	The	the	DT
cord-291950-9gtsqyfj	433	2	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	433	3	is	be	VBZ
cord-291950-9gtsqyfj	433	4	highly	highly	RB
cord-291950-9gtsqyfj	433	5	selective	selective	JJ
cord-291950-9gtsqyfj	433	6	for	for	IN
cord-291950-9gtsqyfj	433	7	Xaa	Xaa	NNP
cord-291950-9gtsqyfj	433	8	-	-	HYPH
cord-291950-9gtsqyfj	433	9	Xbb	Xbb	NNP
cord-291950-9gtsqyfj	433	10	-	-	HYPH
cord-291950-9gtsqyfj	433	11	Gly	Gly	NNP
cord-291950-9gtsqyfj	433	12	-	-	HYPH
cord-291950-9gtsqyfj	433	13	XbbkXbb	XbbkXbb	NNP
cord-291950-9gtsqyfj	433	14	bonds	bond	NNS
cord-291950-9gtsqyfj	433	15	,	,	,
cord-291950-9gtsqyfj	433	16	in	in	IN
cord-291950-9gtsqyfj	433	17	which	which	WDT
cord-291950-9gtsqyfj	433	18	Xaa	Xaa	NNP
cord-291950-9gtsqyfj	433	19	is	be	VBZ
cord-291950-9gtsqyfj	433	20	either	either	CC
cord-291950-9gtsqyfj	433	21	Met	Met	NNP
cord-291950-9gtsqyfj	433	22	,	,	,
cord-291950-9gtsqyfj	433	23	Leu	Leu	NNP
cord-291950-9gtsqyfj	433	24	or	or	CC
cord-291950-9gtsqyfj	433	25	Ile	Ile	NNP
cord-291950-9gtsqyfj	433	26	,	,	,
cord-291950-9gtsqyfj	433	27	and	and	CC
cord-291950-9gtsqyfj	433	28	Xbb	Xbb	NNP
cord-291950-9gtsqyfj	433	29	is	be	VBZ
cord-291950-9gtsqyfj	433	30	any	any	DT
cord-291950-9gtsqyfj	433	31	amino	amino	NN
cord-291950-9gtsqyfj	433	32	acid	acid	NN
cord-291950-9gtsqyfj	433	33	.	.	.
cord-291950-9gtsqyfj	434	1	A	a	DT
cord-291950-9gtsqyfj	434	2	virally	virally	RB
cord-291950-9gtsqyfj	434	3	encoded	encode	VBN
cord-291950-9gtsqyfj	434	4	,	,	,
cord-291950-9gtsqyfj	434	5	eleven	eleven	CD
cord-291950-9gtsqyfj	434	6	residue	residue	NN
cord-291950-9gtsqyfj	434	7	cofactor	cofactor	NN
cord-291950-9gtsqyfj	434	8	is	be	VBZ
cord-291950-9gtsqyfj	434	9	also	also	RB
cord-291950-9gtsqyfj	434	10	required	require	VBN
cord-291950-9gtsqyfj	434	11	for	for	IN
cord-291950-9gtsqyfj	434	12	activity	activity	NN
cord-291950-9gtsqyfj	434	13	[	[	-LRB-
cord-291950-9gtsqyfj	434	14	78	78	CD
cord-291950-9gtsqyfj	434	15	]	]	-RRB-
cord-291950-9gtsqyfj	434	16	,	,	,
cord-291950-9gtsqyfj	434	17	and	and	CC
cord-291950-9gtsqyfj	434	18	the	the	DT
cord-291950-9gtsqyfj	434	19	enzyme	enzyme	NN
cord-291950-9gtsqyfj	434	20	is	be	VBZ
cord-291950-9gtsqyfj	434	21	apparently	apparently	RB
cord-291950-9gtsqyfj	434	22	further	further	RB
cord-291950-9gtsqyfj	434	23	activated	activate	VBN
cord-291950-9gtsqyfj	434	24	by	by	IN
cord-291950-9gtsqyfj	434	25	interaction	interaction	NN
cord-291950-9gtsqyfj	434	26	with	with	IN
cord-291950-9gtsqyfj	434	27	DNA	DNA	NNP
cord-291950-9gtsqyfj	434	28	.	.	.
cord-291950-9gtsqyfj	435	1	In	in	IN
cord-291950-9gtsqyfj	435	2	Family	Family	NNP
cord-291950-9gtsqyfj	435	3	C48	C48	NNP
cord-291950-9gtsqyfj	435	4	the	the	DT
cord-291950-9gtsqyfj	435	5	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	435	6	structure	structure	NN
cord-291950-9gtsqyfj	435	7	of	of	IN
cord-291950-9gtsqyfj	435	8	the	the	DT
cord-291950-9gtsqyfj	435	9	yeast	yeast	NN
cord-291950-9gtsqyfj	435	10	Ulp1	Ulp1	NNP
cord-291950-9gtsqyfj	435	11	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	435	12	(	(	-LRB-
cord-291950-9gtsqyfj	435	13	Chapter	chapter	NN
cord-291950-9gtsqyfj	435	14	527	527	CD
cord-291950-9gtsqyfj	435	15	)	)	-RRB-
cord-291950-9gtsqyfj	435	16	shows	show	VBZ
cord-291950-9gtsqyfj	435	17	a	a	DT
cord-291950-9gtsqyfj	435	18	similar	similar	JJ
cord-291950-9gtsqyfj	435	19	protein	protein	NN
cord-291950-9gtsqyfj	435	20	fold	fold	RB
cord-291950-9gtsqyfj	435	21	to	to	IN
cord-291950-9gtsqyfj	435	22	adenain	adenain	NNP
cord-291950-9gtsqyfj	436	1	(	(	-LRB-
cord-291950-9gtsqyfj	436	2	Figure	figure	NN
cord-291950-9gtsqyfj	436	3	404	404	CD
cord-291950-9gtsqyfj	436	4	.30	.30	CD
cord-291950-9gtsqyfj	436	5	)	)	-RRB-
cord-291950-9gtsqyfj	436	6	.	.	.
cord-291950-9gtsqyfj	437	1	The	the	DT
cord-291950-9gtsqyfj	437	2	Ulp1	Ulp1	NNP
cord-291950-9gtsqyfj	437	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	437	4	is	be	VBZ
cord-291950-9gtsqyfj	437	5	responsible	responsible	JJ
cord-291950-9gtsqyfj	437	6	for	for	IN
cord-291950-9gtsqyfj	437	7	the	the	DT
cord-291950-9gtsqyfj	437	8	release	release	NN
cord-291950-9gtsqyfj	437	9	of	of	IN
cord-291950-9gtsqyfj	437	10	the	the	DT
cord-291950-9gtsqyfj	437	11	Smt3	Smt3	NNP
cord-291950-9gtsqyfj	437	12	proteins	protein	NNS
cord-291950-9gtsqyfj	437	13	.	.	.
cord-291950-9gtsqyfj	438	1	Smt3	Smt3	NNS
cord-291950-9gtsqyfj	438	2	and	and	CC
cord-291950-9gtsqyfj	438	3	the	the	DT
cord-291950-9gtsqyfj	438	4	animal	animal	NN
cord-291950-9gtsqyfj	438	5	equivalent	equivalent	JJ
cord-291950-9gtsqyfj	438	6	SUMO-1	SUMO-1	NNP
cord-291950-9gtsqyfj	438	7	(	(	-LRB-
cord-291950-9gtsqyfj	438	8	also	also	RB
cord-291950-9gtsqyfj	438	9	known	know	VBN
cord-291950-9gtsqyfj	438	10	as	as	IN
cord-291950-9gtsqyfj	438	11	sentrin	sentrin	NNP
cord-291950-9gtsqyfj	438	12	)	)	-RRB-
cord-291950-9gtsqyfj	438	13	are	be	VBP
cord-291950-9gtsqyfj	438	14	proteins	protein	NNS
cord-291950-9gtsqyfj	438	15	that	that	WDT
cord-291950-9gtsqyfj	438	16	target	target	VBP
cord-291950-9gtsqyfj	438	17	other	other	JJ
cord-291950-9gtsqyfj	438	18	proteins	protein	NNS
cord-291950-9gtsqyfj	438	19	for	for	IN
cord-291950-9gtsqyfj	438	20	export	export	NN
cord-291950-9gtsqyfj	438	21	from	from	IN
cord-291950-9gtsqyfj	438	22	the	the	DT
cord-291950-9gtsqyfj	438	23	nucleus	nucleus	NN
cord-291950-9gtsqyfj	438	24	via	via	IN
cord-291950-9gtsqyfj	438	25	the	the	DT
cord-291950-9gtsqyfj	438	26	nuclear	nuclear	JJ
cord-291950-9gtsqyfj	438	27	pore	pore	NN
cord-291950-9gtsqyfj	438	28	complex	complex	NN
cord-291950-9gtsqyfj	438	29	protein	protein	NN
cord-291950-9gtsqyfj	438	30	RANBP2	RANBP2	NNP
cord-291950-9gtsqyfj	438	31	.	.	.
cord-291950-9gtsqyfj	439	1	Smt3	Smt3	NNS
cord-291950-9gtsqyfj	439	2	and	and	CC
cord-291950-9gtsqyfj	439	3	SUMO-1	SUMO-1	NNP
cord-291950-9gtsqyfj	439	4	are	be	VBP
cord-291950-9gtsqyfj	439	5	distantly	distantly	RB
cord-291950-9gtsqyfj	439	6	related	relate	VBN
cord-291950-9gtsqyfj	439	7	to	to	IN
cord-291950-9gtsqyfj	439	8	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	439	9	,	,	,
cord-291950-9gtsqyfj	439	10	and	and	CC
cord-291950-9gtsqyfj	439	11	like	like	IN
cord-291950-9gtsqyfj	439	12	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	439	13	possess	possess	VBP
cord-291950-9gtsqyfj	439	14	C	c	NN
cord-291950-9gtsqyfj	439	15	-	-	HYPH
cord-291950-9gtsqyfj	439	16	terminal	terminal	NN
cord-291950-9gtsqyfj	439	17	glycine	glycine	NN
cord-291950-9gtsqyfj	439	18	residues	residue	NNS
cord-291950-9gtsqyfj	439	19	that	that	WDT
cord-291950-9gtsqyfj	439	20	can	can	MD
cord-291950-9gtsqyfj	439	21	be	be	VB
cord-291950-9gtsqyfj	439	22	linked	link	VBN
cord-291950-9gtsqyfj	439	23	in	in	IN
cord-291950-9gtsqyfj	439	24	isopeptide	isopeptide	NN
cord-291950-9gtsqyfj	439	25	bonds	bond	NNS
cord-291950-9gtsqyfj	439	26	.	.	.
cord-291950-9gtsqyfj	440	1	Unlike	unlike	IN
cord-291950-9gtsqyfj	440	2	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	440	3	,	,	,
cord-291950-9gtsqyfj	440	4	Smt3	Smt3	NNP
cord-291950-9gtsqyfj	440	5	and	and	CC
cord-291950-9gtsqyfj	440	6	SUMO-1	SUMO-1	NNP
cord-291950-9gtsqyfj	440	7	do	do	VBP
cord-291950-9gtsqyfj	440	8	not	not	RB
cord-291950-9gtsqyfj	440	9	target	target	VB
cord-291950-9gtsqyfj	440	10	proteins	protein	NNS
cord-291950-9gtsqyfj	440	11	for	for	IN
cord-291950-9gtsqyfj	440	12	degradation	degradation	NN
cord-291950-9gtsqyfj	440	13	,	,	,
cord-291950-9gtsqyfj	440	14	and	and	CC
cord-291950-9gtsqyfj	440	15	do	do	VBP
cord-291950-9gtsqyfj	440	16	not	not	RB
cord-291950-9gtsqyfj	440	17	form	form	VB
cord-291950-9gtsqyfj	440	18	homopolymers	homopolymer	NNS
cord-291950-9gtsqyfj	440	19	,	,	,
cord-291950-9gtsqyfj	440	20	because	because	IN
cord-291950-9gtsqyfj	440	21	the	the	DT
cord-291950-9gtsqyfj	440	22	lysine	lysine	NN
cord-291950-9gtsqyfj	440	23	essential	essential	JJ
cord-291950-9gtsqyfj	440	24	to	to	IN
cord-291950-9gtsqyfj	440	25	that	that	DT
cord-291950-9gtsqyfj	440	26	process	process	NN
cord-291950-9gtsqyfj	440	27	is	be	VBZ
cord-291950-9gtsqyfj	440	28	not	not	RB
cord-291950-9gtsqyfj	440	29	present	present	JJ
cord-291950-9gtsqyfj	440	30	.	.	.
cord-291950-9gtsqyfj	441	1	The	the	DT
cord-291950-9gtsqyfj	441	2	Ulp1	Ulp1	NNP
cord-291950-9gtsqyfj	441	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	441	4	releases	release	VBZ
cord-291950-9gtsqyfj	441	5	Smt3	Smt3	NNP
cord-291950-9gtsqyfj	441	6	from	from	IN
cord-291950-9gtsqyfj	441	7	its	-PRON-	PRP$
cord-291950-9gtsqyfj	441	8	precursor	precursor	NN
cord-291950-9gtsqyfj	441	9	by	by	IN
cord-291950-9gtsqyfj	441	10	removing	remove	VBG
cord-291950-9gtsqyfj	441	11	three	three	CD
cord-291950-9gtsqyfj	441	12	C	c	NN
cord-291950-9gtsqyfj	441	13	-	-	HYPH
cord-291950-9gtsqyfj	441	14	terminal	terminal	NN
cord-291950-9gtsqyfj	441	15	residues	residue	NNS
cord-291950-9gtsqyfj	441	16	to	to	TO
cord-291950-9gtsqyfj	441	17	expose	expose	VB
cord-291950-9gtsqyfj	441	18	the	the	DT
cord-291950-9gtsqyfj	441	19	-Gly	-Gly	:
cord-291950-9gtsqyfj	441	20	-	-	HYPH
cord-291950-9gtsqyfj	441	21	Gly	Gly	NNP
cord-291950-9gtsqyfj	441	22	C	c	NN
cord-291950-9gtsqyfj	441	23	-	-	HYPH
cord-291950-9gtsqyfj	441	24	terminus	terminus	NN
cord-291950-9gtsqyfj	441	25	;	;	.
cord-291950-9gtsqyfj	442	1	the	the	DT
cord-291950-9gtsqyfj	442	2	mammalian	mammalian	JJ
cord-291950-9gtsqyfj	442	3	equivalent	equivalent	NN
cord-291950-9gtsqyfj	442	4	,	,	,
cord-291950-9gtsqyfj	442	5	SENP1-endopeptidase	SENP1-endopeptidase	NNP
cord-291950-9gtsqyfj	442	6	,	,	,
cord-291950-9gtsqyfj	442	7	removes	remove	VBZ
cord-291950-9gtsqyfj	442	8	four	four	CD
cord-291950-9gtsqyfj	442	9	C	c	NN
cord-291950-9gtsqyfj	442	10	-	-	HYPH
cord-291950-9gtsqyfj	442	11	terminal	terminal	NN
cord-291950-9gtsqyfj	442	12	residues	residue	NNS
cord-291950-9gtsqyfj	442	13	.	.	.
cord-291950-9gtsqyfj	443	1	Ulp1	Ulp1	NNP
cord-291950-9gtsqyfj	443	2	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	443	3	can	can	MD
cord-291950-9gtsqyfj	443	4	also	also	RB
cord-291950-9gtsqyfj	443	5	release	release	VB
cord-291950-9gtsqyfj	443	6	Smt3	Smt3	NNP
cord-291950-9gtsqyfj	443	7	from	from	IN
cord-291950-9gtsqyfj	443	8	targeted	target	VBN
cord-291950-9gtsqyfj	443	9	proteins	protein	NNS
cord-291950-9gtsqyfj	443	10	.	.	.
cord-291950-9gtsqyfj	444	1	The	the	DT
cord-291950-9gtsqyfj	444	2	enzyme	enzyme	NN
cord-291950-9gtsqyfj	444	3	is	be	VBZ
cord-291950-9gtsqyfj	444	4	normally	normally	RB
cord-291950-9gtsqyfj	444	5	localized	localize	VBN
cord-291950-9gtsqyfj	444	6	to	to	IN
cord-291950-9gtsqyfj	444	7	the	the	DT
cord-291950-9gtsqyfj	444	8	periphery	periphery	NN
cord-291950-9gtsqyfj	444	9	of	of	IN
cord-291950-9gtsqyfj	444	10	the	the	DT
cord-291950-9gtsqyfj	444	11	nucleus	nucleus	NN
cord-291950-9gtsqyfj	444	12	,	,	,
cord-291950-9gtsqyfj	444	13	but	but	CC
cord-291950-9gtsqyfj	444	14	is	be	VBZ
cord-291950-9gtsqyfj	444	15	found	find	VBN
cord-291950-9gtsqyfj	444	16	within	within	IN
cord-291950-9gtsqyfj	444	17	the	the	DT
cord-291950-9gtsqyfj	444	18	nucleus	nucleus	NN
cord-291950-9gtsqyfj	444	19	during	during	IN
cord-291950-9gtsqyfj	444	20	mitotic	mitotic	JJ
cord-291950-9gtsqyfj	444	21	anaphase	anaphase	NN
cord-291950-9gtsqyfj	444	22	.	.	.
cord-291950-9gtsqyfj	445	1	Family	Family	NNP
cord-291950-9gtsqyfj	445	2	C55	C55	NNP
cord-291950-9gtsqyfj	445	3	is	be	VBZ
cord-291950-9gtsqyfj	445	4	that	that	DT
cord-291950-9gtsqyfj	445	5	of	of	IN
cord-291950-9gtsqyfj	445	6	the	the	DT
cord-291950-9gtsqyfj	445	7	YopJ	YopJ	NNP
cord-291950-9gtsqyfj	445	8	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	445	9	from	from	IN
cord-291950-9gtsqyfj	445	10	Yersinia	Yersinia	NNP
cord-291950-9gtsqyfj	445	11	(	(	-LRB-
cord-291950-9gtsqyfj	445	12	Chapter	chapter	NN
cord-291950-9gtsqyfj	445	13	69	69	CD
cord-291950-9gtsqyfj	445	14	)	)	-RRB-
cord-291950-9gtsqyfj	445	15	.	.	.
cord-291950-9gtsqyfj	446	1	The	the	DT
cord-291950-9gtsqyfj	446	2	YopJ	YopJ	NNP
cord-291950-9gtsqyfj	446	3	protein	protein	NN
cord-291950-9gtsqyfj	446	4	contributes	contribute	VBZ
cord-291950-9gtsqyfj	446	5	to	to	IN
cord-291950-9gtsqyfj	446	6	the	the	DT
cord-291950-9gtsqyfj	446	7	disease	disease	NN
cord-291950-9gtsqyfj	446	8	process	process	NN
cord-291950-9gtsqyfj	446	9	by	by	IN
cord-291950-9gtsqyfj	446	10	causing	cause	VBG
cord-291950-9gtsqyfj	446	11	host	host	NN
cord-291950-9gtsqyfj	446	12	macrophages	macrophage	NNS
cord-291950-9gtsqyfj	446	13	to	to	TO
cord-291950-9gtsqyfj	446	14	undergo	undergo	VB
cord-291950-9gtsqyfj	446	15	apoptosis	apoptosis	NN
cord-291950-9gtsqyfj	446	16	and	and	CC
cord-291950-9gtsqyfj	446	17	suppressing	suppress	VBG
cord-291950-9gtsqyfj	446	18	the	the	DT
cord-291950-9gtsqyfj	446	19	action	action	NN
cord-291950-9gtsqyfj	446	20	of	of	IN
cord-291950-9gtsqyfj	446	21	cytokines	cytokine	NNS
cord-291950-9gtsqyfj	446	22	such	such	JJ
cord-291950-9gtsqyfj	446	23	as	as	IN
cord-291950-9gtsqyfj	446	24	TNFα	TNFα	NNS
cord-291950-9gtsqyfj	446	25	and	and	CC
cord-291950-9gtsqyfj	446	26	NF	nf	NN
cord-291950-9gtsqyfj	446	27	-	-	HYPH
cord-291950-9gtsqyfj	446	28	κB.	κb.	NN
cord-291950-9gtsqyfj	446	29	YopJ	YopJ	NNP
cord-291950-9gtsqyfj	446	30	is	be	VBZ
cord-291950-9gtsqyfj	446	31	thought	think	VBN
cord-291950-9gtsqyfj	446	32	to	to	TO
cord-291950-9gtsqyfj	446	33	act	act	VB
cord-291950-9gtsqyfj	446	34	by	by	IN
cord-291950-9gtsqyfj	446	35	cleaving	cleave	VBG
cord-291950-9gtsqyfj	446	36	the	the	DT
cord-291950-9gtsqyfj	446	37	Bid	Bid	NNP
cord-291950-9gtsqyfj	446	38	protein	protein	NN
cord-291950-9gtsqyfj	446	39	,	,	,
cord-291950-9gtsqyfj	446	40	which	which	WDT
cord-291950-9gtsqyfj	446	41	then	then	RB
cord-291950-9gtsqyfj	446	42	induces	induce	VBZ
cord-291950-9gtsqyfj	446	43	apoptosis	apoptosis	NN
cord-291950-9gtsqyfj	446	44	by	by	IN
cord-291950-9gtsqyfj	446	45	translocating	translocate	VBG
cord-291950-9gtsqyfj	446	46	to	to	IN
cord-291950-9gtsqyfj	446	47	the	the	DT
cord-291950-9gtsqyfj	446	48	mitochondrion	mitochondrion	NN
cord-291950-9gtsqyfj	446	49	,	,	,
cord-291950-9gtsqyfj	446	50	causing	cause	VBG
cord-291950-9gtsqyfj	446	51	the	the	DT
cord-291950-9gtsqyfj	446	52	release	release	NN
cord-291950-9gtsqyfj	446	53	of	of	IN
cord-291950-9gtsqyfj	446	54	cytochrome	cytochrome	NN
cord-291950-9gtsqyfj	446	55	c	c	NN
cord-291950-9gtsqyfj	446	56	and	and	CC
cord-291950-9gtsqyfj	446	57	the	the	DT
cord-291950-9gtsqyfj	446	58	activation	activation	NN
cord-291950-9gtsqyfj	446	59	of	of	IN
cord-291950-9gtsqyfj	446	60	caspases	caspase	NNS
cord-291950-9gtsqyfj	446	61	9	9	CD
cord-291950-9gtsqyfj	446	62	,	,	,
cord-291950-9gtsqyfj	446	63	3	3	CD
cord-291950-9gtsqyfj	446	64	and	and	CC
cord-291950-9gtsqyfj	446	65	7	7	CD
cord-291950-9gtsqyfj	446	66	[	[	-LRB-
cord-291950-9gtsqyfj	446	67	79	79	CD
cord-291950-9gtsqyfj	446	68	]	]	-RRB-
cord-291950-9gtsqyfj	446	69	.	.	.
cord-291950-9gtsqyfj	447	1	YopJ	YopJ	NNP
cord-291950-9gtsqyfj	447	2	is	be	VBZ
cord-291950-9gtsqyfj	447	3	an	an	DT
cord-291950-9gtsqyfj	447	4	outer	outer	JJ
cord-291950-9gtsqyfj	447	5	membrane	membrane	NN
cord-291950-9gtsqyfj	447	6	protein	protein	NN
cord-291950-9gtsqyfj	447	7	that	that	WDT
cord-291950-9gtsqyfj	447	8	is	be	VBZ
cord-291950-9gtsqyfj	447	9	encoded	encode	VBN
cord-291950-9gtsqyfj	447	10	on	on	IN
cord-291950-9gtsqyfj	447	11	a	a	DT
cord-291950-9gtsqyfj	447	12	plasmid	plasmid	NN
cord-291950-9gtsqyfj	447	13	.	.	.
cord-291950-9gtsqyfj	448	1	There	there	EX
cord-291950-9gtsqyfj	448	2	are	be	VBP
cord-291950-9gtsqyfj	448	3	a	a	DT
cord-291950-9gtsqyfj	448	4	number	number	NN
cord-291950-9gtsqyfj	448	5	of	of	IN
cord-291950-9gtsqyfj	448	6	homologs	homolog	NNS
cord-291950-9gtsqyfj	448	7	in	in	IN
cord-291950-9gtsqyfj	448	8	this	this	DT
cord-291950-9gtsqyfj	448	9	family	family	NN
cord-291950-9gtsqyfj	448	10	that	that	WDT
cord-291950-9gtsqyfj	448	11	are	be	VBP
cord-291950-9gtsqyfj	448	12	not	not	RB
cord-291950-9gtsqyfj	448	13	known	know	VBN
cord-291950-9gtsqyfj	448	14	to	to	TO
cord-291950-9gtsqyfj	448	15	be	be	VB
cord-291950-9gtsqyfj	448	16	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	448	17	(	(	-LRB-
cord-291950-9gtsqyfj	448	18	even	even	RB
cord-291950-9gtsqyfj	448	19	though	though	IN
cord-291950-9gtsqyfj	448	20	all	all	PDT
cord-291950-9gtsqyfj	448	21	the	the	DT
cord-291950-9gtsqyfj	448	22	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	448	23	residues	residue	NNS
cord-291950-9gtsqyfj	448	24	are	be	VBP
cord-291950-9gtsqyfj	448	25	conserved	conserve	VBN
cord-291950-9gtsqyfj	448	26	)	)	-RRB-
cord-291950-9gtsqyfj	448	27	including	include	VBG
cord-291950-9gtsqyfj	448	28	avirulence	avirulence	NN
cord-291950-9gtsqyfj	448	29	protein	protein	NN
cord-291950-9gtsqyfj	448	30	AvrBsT	AvrBsT	NNP
cord-291950-9gtsqyfj	448	31	from	from	IN
cord-291950-9gtsqyfj	448	32	Xanthomonas	Xanthomonas	NNP
cord-291950-9gtsqyfj	448	33	.	.	.
cord-291950-9gtsqyfj	449	1	The	the	DT
cord-291950-9gtsqyfj	449	2	family	family	NN
cord-291950-9gtsqyfj	449	3	is	be	VBZ
cord-291950-9gtsqyfj	449	4	known	know	VBN
cord-291950-9gtsqyfj	449	5	only	only	RB
cord-291950-9gtsqyfj	449	6	from	from	IN
cord-291950-9gtsqyfj	449	7	Proteobacteria	Proteobacteria	NNP
cord-291950-9gtsqyfj	449	8	.	.	.
cord-291950-9gtsqyfj	450	1	Although	although	IN
cord-291950-9gtsqyfj	450	2	no	no	DT
cord-291950-9gtsqyfj	450	3	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	450	4	residues	residue	NNS
cord-291950-9gtsqyfj	450	5	have	have	VBP
cord-291950-9gtsqyfj	450	6	been	be	VBN
cord-291950-9gtsqyfj	450	7	identified	identify	VBN
cord-291950-9gtsqyfj	450	8	for	for	IN
cord-291950-9gtsqyfj	450	9	any	any	DT
cord-291950-9gtsqyfj	450	10	member	member	NN
cord-291950-9gtsqyfj	450	11	of	of	IN
cord-291950-9gtsqyfj	450	12	the	the	DT
cord-291950-9gtsqyfj	450	13	family	family	NN
cord-291950-9gtsqyfj	450	14	,	,	,
cord-291950-9gtsqyfj	450	15	they	-PRON-	PRP
cord-291950-9gtsqyfj	450	16	are	be	VBP
cord-291950-9gtsqyfj	450	17	predicted	predict	VBN
cord-291950-9gtsqyfj	450	18	to	to	TO
cord-291950-9gtsqyfj	450	19	occur	occur	VB
cord-291950-9gtsqyfj	450	20	in	in	IN
cord-291950-9gtsqyfj	450	21	the	the	DT
cord-291950-9gtsqyfj	450	22	order	order	NN
cord-291950-9gtsqyfj	450	23	His	-PRON-	PRP$
cord-291950-9gtsqyfj	450	24	,	,	,
cord-291950-9gtsqyfj	450	25	Glu	Glu	NNP
cord-291950-9gtsqyfj	450	26	,	,	,
cord-291950-9gtsqyfj	450	27	Gln	Gln	NNP
cord-291950-9gtsqyfj	450	28	,	,	,
cord-291950-9gtsqyfj	450	29	Cys	Cys	NNP
cord-291950-9gtsqyfj	450	30	.	.	.
cord-291950-9gtsqyfj	451	1	Family	Family	NNP
cord-291950-9gtsqyfj	451	2	C57	C57	NNP
cord-291950-9gtsqyfj	451	3	contains	contain	VBZ
cord-291950-9gtsqyfj	451	4	the	the	DT
cord-291950-9gtsqyfj	451	5	I7	I7	NNP
cord-291950-9gtsqyfj	451	6	protein	protein	NN
cord-291950-9gtsqyfj	451	7	from	from	IN
cord-291950-9gtsqyfj	451	8	the	the	DT
cord-291950-9gtsqyfj	451	9	vaccinia	vaccinia	NN
cord-291950-9gtsqyfj	451	10	virus	virus	NN
cord-291950-9gtsqyfj	451	11	(	(	-LRB-
cord-291950-9gtsqyfj	451	12	Chapter	chapter	NN
cord-291950-9gtsqyfj	451	13	535	535	CD
cord-291950-9gtsqyfj	451	14	)	)	-RRB-
cord-291950-9gtsqyfj	451	15	,	,	,
cord-291950-9gtsqyfj	451	16	which	which	WDT
cord-291950-9gtsqyfj	451	17	is	be	VBZ
cord-291950-9gtsqyfj	451	18	believed	believe	VBN
cord-291950-9gtsqyfj	451	19	to	to	TO
cord-291950-9gtsqyfj	451	20	be	be	VB
cord-291950-9gtsqyfj	451	21	a	a	DT
cord-291950-9gtsqyfj	451	22	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	451	23	processing	processing	NN
cord-291950-9gtsqyfj	451	24	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	451	25	.	.	.
cord-291950-9gtsqyfj	452	1	Although	although	IN
cord-291950-9gtsqyfj	452	2	no	no	DT
cord-291950-9gtsqyfj	452	3	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	452	4	residues	residue	NNS
cord-291950-9gtsqyfj	452	5	have	have	VBP
cord-291950-9gtsqyfj	452	6	been	be	VBN
cord-291950-9gtsqyfj	452	7	identified	identify	VBN
cord-291950-9gtsqyfj	452	8	for	for	IN
cord-291950-9gtsqyfj	452	9	any	any	DT
cord-291950-9gtsqyfj	452	10	member	member	NN
cord-291950-9gtsqyfj	452	11	of	of	IN
cord-291950-9gtsqyfj	452	12	the	the	DT
cord-291950-9gtsqyfj	452	13	family	family	NN
cord-291950-9gtsqyfj	452	14	,	,	,
cord-291950-9gtsqyfj	452	15	they	-PRON-	PRP
cord-291950-9gtsqyfj	452	16	are	be	VBP
cord-291950-9gtsqyfj	452	17	predicted	predict	VBN
cord-291950-9gtsqyfj	452	18	to	to	TO
cord-291950-9gtsqyfj	452	19	occur	occur	VB
cord-291950-9gtsqyfj	452	20	in	in	IN
cord-291950-9gtsqyfj	452	21	the	the	DT
cord-291950-9gtsqyfj	452	22	order	order	NN
cord-291950-9gtsqyfj	453	1	His	-PRON-	PRP$
cord-291950-9gtsqyfj	453	2	,	,	,
cord-291950-9gtsqyfj	453	3	Asp	Asp	NNP
cord-291950-9gtsqyfj	453	4	/	/	SYM
cord-291950-9gtsqyfj	453	5	Asn	Asn	NNP
cord-291950-9gtsqyfj	453	6	,	,	,
cord-291950-9gtsqyfj	453	7	Gln	Gln	NNP
cord-291950-9gtsqyfj	453	8	,	,	,
cord-291950-9gtsqyfj	453	9	Cys	Cys	NNP
cord-291950-9gtsqyfj	453	10	.	.	.
cord-291950-9gtsqyfj	454	1	The	the	DT
cord-291950-9gtsqyfj	454	2	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	454	3	processing	processing	NN
cord-291950-9gtsqyfj	454	4	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	454	5	present	present	JJ
cord-291950-9gtsqyfj	454	6	in	in	IN
cord-291950-9gtsqyfj	454	7	the	the	DT
cord-291950-9gtsqyfj	454	8	African	african	JJ
cord-291950-9gtsqyfj	454	9	swine	swine	NN
cord-291950-9gtsqyfj	454	10	fever	fever	NN
cord-291950-9gtsqyfj	454	11	virus	virus	NN
cord-291950-9gtsqyfj	454	12	(	(	-LRB-
cord-291950-9gtsqyfj	454	13	Chapter	chapter	NN
cord-291950-9gtsqyfj	454	14	534	534	CD
cord-291950-9gtsqyfj	454	15	)	)	-RRB-
cord-291950-9gtsqyfj	454	16	is	be	VBZ
cord-291950-9gtsqyfj	454	17	included	include	VBN
cord-291950-9gtsqyfj	454	18	in	in	IN
cord-291950-9gtsqyfj	454	19	family	family	NN
cord-291950-9gtsqyfj	454	20	C63	C63	NNP
cord-291950-9gtsqyfj	454	21	.	.	.
cord-291950-9gtsqyfj	455	1	Although	although	IN
cord-291950-9gtsqyfj	455	2	no	no	DT
cord-291950-9gtsqyfj	455	3	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	455	4	structure	structure	NN
cord-291950-9gtsqyfj	455	5	has	have	VBZ
cord-291950-9gtsqyfj	455	6	been	be	VBN
cord-291950-9gtsqyfj	455	7	solved	solve	VBN
cord-291950-9gtsqyfj	455	8	,	,	,
cord-291950-9gtsqyfj	455	9	the	the	DT
cord-291950-9gtsqyfj	455	10	order	order	NN
cord-291950-9gtsqyfj	455	11	of	of	IN
cord-291950-9gtsqyfj	455	12	active	active	JJ
cord-291950-9gtsqyfj	455	13	site	site	NN
cord-291950-9gtsqyfj	455	14	residues	residue	NNS
cord-291950-9gtsqyfj	455	15	(	(	-LRB-
cord-291950-9gtsqyfj	455	16	His	-PRON-	PRP$
cord-291950-9gtsqyfj	455	17	,	,	,
cord-291950-9gtsqyfj	455	18	Asn	Asn	NNP
cord-291950-9gtsqyfj	455	19	,	,	,
cord-291950-9gtsqyfj	455	20	Gln	Gln	NNP
cord-291950-9gtsqyfj	455	21	,	,	,
cord-291950-9gtsqyfj	455	22	Cys	Cys	NNP
cord-291950-9gtsqyfj	455	23	)	)	-RRB-
cord-291950-9gtsqyfj	455	24	is	be	VBZ
cord-291950-9gtsqyfj	455	25	consistent	consistent	JJ
cord-291950-9gtsqyfj	455	26	with	with	IN
cord-291950-9gtsqyfj	455	27	membership	membership	NN
cord-291950-9gtsqyfj	455	28	of	of	IN
cord-291950-9gtsqyfj	455	29	clan	clan	NN
cord-291950-9gtsqyfj	455	30	CE	CE	NNP
cord-291950-9gtsqyfj	455	31	,	,	,
cord-291950-9gtsqyfj	455	32	as	as	IN
cord-291950-9gtsqyfj	455	33	is	be	VBZ
cord-291950-9gtsqyfj	455	34	the	the	DT
cord-291950-9gtsqyfj	455	35	restricted	restricted	JJ
cord-291950-9gtsqyfj	455	36	specificity	specificity	NN
cord-291950-9gtsqyfj	455	37	for	for	IN
cord-291950-9gtsqyfj	455	38	Gly	Gly	NNP
cord-291950-9gtsqyfj	455	39	-	-	HYPH
cord-291950-9gtsqyfj	455	40	GlykXaa	GlykXaa	NNP
cord-291950-9gtsqyfj	455	41	bonds	bond	NNS
cord-291950-9gtsqyfj	455	42	[	[	-LRB-
cord-291950-9gtsqyfj	455	43	80	80	CD
cord-291950-9gtsqyfj	455	44	]	]	-RRB-
cord-291950-9gtsqyfj	455	45	.	.	.
cord-291950-9gtsqyfj	456	1	Bacterial	bacterial	JJ
cord-291950-9gtsqyfj	456	2	homologs	homolog	NNS
cord-291950-9gtsqyfj	456	3	are	be	VBP
cord-291950-9gtsqyfj	456	4	known	know	VBN
cord-291950-9gtsqyfj	456	5	from	from	IN
cord-291950-9gtsqyfj	456	6	Chlamydia	Chlamydia	NNP
cord-291950-9gtsqyfj	456	7	,	,	,
cord-291950-9gtsqyfj	456	8	Xanthomonas	Xanthomonas	NNP
cord-291950-9gtsqyfj	456	9	,	,	,
cord-291950-9gtsqyfj	456	10	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	456	11	and	and	CC
cord-291950-9gtsqyfj	456	12	Mesorhizobium	Mesorhizobium	NNP
cord-291950-9gtsqyfj	456	13	but	but	CC
cord-291950-9gtsqyfj	456	14	have	have	VBP
cord-291950-9gtsqyfj	456	15	low	low	JJ
cord-291950-9gtsqyfj	456	16	similarity	similarity	NN
cord-291950-9gtsqyfj	456	17	to	to	IN
cord-291950-9gtsqyfj	456	18	the	the	DT
cord-291950-9gtsqyfj	456	19	eukaryotic	eukaryotic	JJ
cord-291950-9gtsqyfj	456	20	sequences	sequence	NNS
cord-291950-9gtsqyfj	456	21	.	.	.
cord-291950-9gtsqyfj	457	1	The	the	DT
cord-291950-9gtsqyfj	457	2	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	457	3	and	and	CC
cord-291950-9gtsqyfj	457	4	Mesorhizobium	Mesorhizobium	NNP
cord-291950-9gtsqyfj	457	5	homologs	homolog	NNS
cord-291950-9gtsqyfj	457	6	are	be	VBP
cord-291950-9gtsqyfj	457	7	multidomain	multidomain	NNP
cord-291950-9gtsqyfj	457	8	,	,	,
cord-291950-9gtsqyfj	457	9	mosaic	mosaic	JJ
cord-291950-9gtsqyfj	457	10	proteins	protein	NNS
cord-291950-9gtsqyfj	457	11	.	.	.
cord-291950-9gtsqyfj	458	1	No	no	DT
cord-291950-9gtsqyfj	458	2	peptidase	peptidase	NN
cord-291950-9gtsqyfj	458	3	activity	activity	NN
cord-291950-9gtsqyfj	458	4	has	have	VBZ
cord-291950-9gtsqyfj	458	5	yet	yet	RB
cord-291950-9gtsqyfj	458	6	been	be	VBN
cord-291950-9gtsqyfj	458	7	demonstrated	demonstrate	VBN
cord-291950-9gtsqyfj	458	8	for	for	IN
cord-291950-9gtsqyfj	458	9	any	any	DT
cord-291950-9gtsqyfj	458	10	of	of	IN
cord-291950-9gtsqyfj	458	11	the	the	DT
cord-291950-9gtsqyfj	458	12	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	458	13	homologs	homolog	NNS
cord-291950-9gtsqyfj	458	14	,	,	,
cord-291950-9gtsqyfj	458	15	but	but	CC
cord-291950-9gtsqyfj	458	16	the	the	DT
cord-291950-9gtsqyfj	458	17	gene	gene	NN
cord-291950-9gtsqyfj	458	18	has	have	VBZ
cord-291950-9gtsqyfj	458	19	been	be	VBN
cord-291950-9gtsqyfj	458	20	shown	show	VBN
cord-291950-9gtsqyfj	458	21	to	to	TO
cord-291950-9gtsqyfj	458	22	be	be	VB
cord-291950-9gtsqyfj	458	23	encoded	encode	VBN
cord-291950-9gtsqyfj	458	24	on	on	IN
cord-291950-9gtsqyfj	458	25	a	a	DT
cord-291950-9gtsqyfj	458	26	plasmid	plasmid	NN
cord-291950-9gtsqyfj	458	27	and	and	CC
cord-291950-9gtsqyfj	458	28	essential	essential	JJ
cord-291950-9gtsqyfj	458	29	for	for	IN
cord-291950-9gtsqyfj	458	30	virulence	virulence	NN
cord-291950-9gtsqyfj	458	31	in	in	IN
cord-291950-9gtsqyfj	458	32	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	458	33	[	[	-LRB-
cord-291950-9gtsqyfj	458	34	81	81	CD
cord-291950-9gtsqyfj	458	35	]	]	-RRB-
cord-291950-9gtsqyfj	458	36	.	.	.
cord-291950-9gtsqyfj	459	1	No	no	DT
cord-291950-9gtsqyfj	459	2	homologs	homolog	NNS
cord-291950-9gtsqyfj	459	3	are	be	VBP
cord-291950-9gtsqyfj	459	4	known	know	VBN
cord-291950-9gtsqyfj	459	5	from	from	IN
cord-291950-9gtsqyfj	459	6	archaea	archaea	NNS
cord-291950-9gtsqyfj	459	7	.	.	.
cord-291950-9gtsqyfj	460	1	Not	not	RB
cord-291950-9gtsqyfj	460	2	all	all	DT
cord-291950-9gtsqyfj	460	3	deubiquitinating	deubiquitinating	NN
cord-291950-9gtsqyfj	460	4	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	460	5	are	be	VBP
cord-291950-9gtsqyfj	460	6	proteins	protein	NNS
cord-291950-9gtsqyfj	460	7	with	with	IN
cord-291950-9gtsqyfj	460	8	a	a	DT
cord-291950-9gtsqyfj	460	9	papain	papain	NN
cord-291950-9gtsqyfj	460	10	-	-	HYPH
cord-291950-9gtsqyfj	460	11	like	like	IN
cord-291950-9gtsqyfj	460	12	fold	fold	NN
cord-291950-9gtsqyfj	460	13	.	.	.
cord-291950-9gtsqyfj	461	1	The	the	DT
cord-291950-9gtsqyfj	461	2	ElaD	ElaD	NNP
cord-291950-9gtsqyfj	461	3	peptidase	peptidase	NN
cord-291950-9gtsqyfj	461	4	from	from	IN
cord-291950-9gtsqyfj	461	5	Escherichia	Escherichia	NNP
cord-291950-9gtsqyfj	461	6	coli	coli	NNS
cord-291950-9gtsqyfj	461	7	is	be	VBZ
cord-291950-9gtsqyfj	461	8	able	able	JJ
cord-291950-9gtsqyfj	461	9	to	to	TO
cord-291950-9gtsqyfj	461	10	release	release	VB
cord-291950-9gtsqyfj	461	11	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	461	12	from	from	IN
cord-291950-9gtsqyfj	461	13	synthetic	synthetic	JJ
cord-291950-9gtsqyfj	461	14	constructs	construct	NNS
cord-291950-9gtsqyfj	461	15	with	with	IN
cord-291950-9gtsqyfj	461	16	a	a	DT
cord-291950-9gtsqyfj	461	17	preference	preference	NN
cord-291950-9gtsqyfj	461	18	for	for	IN
cord-291950-9gtsqyfj	461	19	Lys63-linked	lys63-linked	NN
cord-291950-9gtsqyfj	461	20	ubiquitin	ubiquitin	JJ
cord-291950-9gtsqyfj	461	21	chains	chain	NNS
cord-291950-9gtsqyfj	461	22	,	,	,
cord-291950-9gtsqyfj	461	23	but	but	CC
cord-291950-9gtsqyfj	461	24	also	also	RB
cord-291950-9gtsqyfj	461	25	cleaving	cleave	VBG
cord-291950-9gtsqyfj	461	26	at	at	IN
cord-291950-9gtsqyfj	461	27	Lys-48	Lys-48	NNP
cord-291950-9gtsqyfj	461	28	[	[	-LRB-
cord-291950-9gtsqyfj	461	29	82	82	CD
cord-291950-9gtsqyfj	461	30	,	,	,
cord-291950-9gtsqyfj	461	31	83	83	CD
cord-291950-9gtsqyfj	461	32	]	]	-RRB-
cord-291950-9gtsqyfj	461	33	.	.	.
cord-291950-9gtsqyfj	462	1	This	this	DT
cord-291950-9gtsqyfj	462	2	peptidase	peptidase	NN
cord-291950-9gtsqyfj	462	3	is	be	VBZ
cord-291950-9gtsqyfj	462	4	included	include	VBN
cord-291950-9gtsqyfj	462	5	in	in	IN
cord-291950-9gtsqyfj	462	6	family	family	NN
cord-291950-9gtsqyfj	462	7	C79	C79	NNP
cord-291950-9gtsqyfj	462	8	.	.	.
cord-291950-9gtsqyfj	463	1	This	this	DT
cord-291950-9gtsqyfj	463	2	family	family	NN
cord-291950-9gtsqyfj	463	3	is	be	VBZ
cord-291950-9gtsqyfj	463	4	included	include	VBN
cord-291950-9gtsqyfj	463	5	in	in	IN
cord-291950-9gtsqyfj	463	6	clan	clan	NN
cord-291950-9gtsqyfj	463	7	CE	CE	NNP
cord-291950-9gtsqyfj	463	8	because	because	IN
cord-291950-9gtsqyfj	463	9	we	-PRON-	PRP
cord-291950-9gtsqyfj	463	10	propose	propose	VBP
cord-291950-9gtsqyfj	463	11	a	a	DT
cord-291950-9gtsqyfj	463	12	His	His	NNP
cord-291950-9gtsqyfj	463	13	,	,	,
cord-291950-9gtsqyfj	463	14	Cys	Cys	NNP
cord-291950-9gtsqyfj	463	15	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	463	16	dyad	dyad	NN
cord-291950-9gtsqyfj	463	17	(	(	-LRB-
cord-291950-9gtsqyfj	463	18	see	see	VB
cord-291950-9gtsqyfj	463	19	the	the	DT
cord-291950-9gtsqyfj	463	20	alignment	alignment	NN
cord-291950-9gtsqyfj	463	21	in	in	IN
cord-291950-9gtsqyfj	463	22	MEROPS	MEROPS	NNP
cord-291950-9gtsqyfj	463	23	)	)	-RRB-
cord-291950-9gtsqyfj	463	24	.	.	.
cord-291950-9gtsqyfj	464	1	Clan	Clan	NNP
cord-291950-9gtsqyfj	464	2	CF	CF	NNP
cord-291950-9gtsqyfj	464	3	,	,	,
cord-291950-9gtsqyfj	464	4	family	family	NN
cord-291950-9gtsqyfj	464	5	C15	C15	NNP
cord-291950-9gtsqyfj	464	6	.	.	.
cord-291950-9gtsqyfj	465	1	The	the	DT
cord-291950-9gtsqyfj	465	2	crystal	crystal	JJ
cord-291950-9gtsqyfj	465	3	structure	structure	NN
cord-291950-9gtsqyfj	465	4	of	of	IN
cord-291950-9gtsqyfj	465	5	pyroglutamyl	pyroglutamyl	JJ
cord-291950-9gtsqyfj	465	6	-	-	HYPH
cord-291950-9gtsqyfj	465	7	peptidase	peptidase	NN
cord-291950-9gtsqyfj	465	8	I	-PRON-	PRP
cord-291950-9gtsqyfj	465	9	from	from	IN
cord-291950-9gtsqyfj	465	10	Thermococcus	Thermococcus	NNP
cord-291950-9gtsqyfj	466	1	(	(	-LRB-
cord-291950-9gtsqyfj	466	2	Figure	figure	NN
cord-291950-9gtsqyfj	466	3	404	404	CD
cord-291950-9gtsqyfj	466	4	.	.	.
cord-291950-9gtsqyfj	466	5	31	31	CD
cord-291950-9gtsqyfj	466	6	)	)	-RRB-
cord-291950-9gtsqyfj	466	7	shows	show	VBZ
cord-291950-9gtsqyfj	466	8	a	a	DT
cord-291950-9gtsqyfj	466	9	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	466	10	triad	triad	NN
cord-291950-9gtsqyfj	466	11	with	with	IN
cord-291950-9gtsqyfj	466	12	the	the	DT
cord-291950-9gtsqyfj	466	13	residues	residue	NNS
cord-291950-9gtsqyfj	466	14	in	in	IN
cord-291950-9gtsqyfj	466	15	the	the	DT
cord-291950-9gtsqyfj	466	16	order	order	NN
cord-291950-9gtsqyfj	466	17	Glu	Glu	NNP
cord-291950-9gtsqyfj	466	18	,	,	,
cord-291950-9gtsqyfj	466	19	Cys	Cys	NNP
cord-291950-9gtsqyfj	466	20	,	,	,
cord-291950-9gtsqyfj	467	1	His	-PRON-	PRP$
cord-291950-9gtsqyfj	467	2	in	in	IN
cord-291950-9gtsqyfj	467	3	the	the	DT
cord-291950-9gtsqyfj	467	4	sequence	sequence	NN
cord-291950-9gtsqyfj	467	5	,	,	,
cord-291950-9gtsqyfj	467	6	which	which	WDT
cord-291950-9gtsqyfj	467	7	is	be	VBZ
cord-291950-9gtsqyfj	467	8	different	different	JJ
cord-291950-9gtsqyfj	467	9	to	to	IN
cord-291950-9gtsqyfj	467	10	any	any	DT
cord-291950-9gtsqyfj	467	11	other	other	JJ
cord-291950-9gtsqyfj	467	12	clan	clan	NN
cord-291950-9gtsqyfj	467	13	of	of	IN
cord-291950-9gtsqyfj	467	14	cysteine	cysteine	NN
cord-291950-9gtsqyfj	467	15	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	467	16	.	.	.
cord-291950-9gtsqyfj	468	1	The	the	DT
cord-291950-9gtsqyfj	468	2	enzyme	enzyme	NN
cord-291950-9gtsqyfj	468	3	is	be	VBZ
cord-291950-9gtsqyfj	468	4	an	an	DT
cord-291950-9gtsqyfj	468	5	intracellular	intracellular	JJ
cord-291950-9gtsqyfj	468	6	omega	omega	NN
cord-291950-9gtsqyfj	468	7	peptidase	peptidase	NN
cord-291950-9gtsqyfj	468	8	that	that	WDT
cord-291950-9gtsqyfj	468	9	removes	remove	VBZ
cord-291950-9gtsqyfj	468	10	an	an	DT
cord-291950-9gtsqyfj	468	11	N	n	CD
cord-291950-9gtsqyfj	468	12	-	-	HYPH
cord-291950-9gtsqyfj	468	13	terminal	terminal	NN
cord-291950-9gtsqyfj	468	14	pyroglutamyl	pyroglutamyl	NN
cord-291950-9gtsqyfj	468	15	residue	residue	NN
cord-291950-9gtsqyfj	468	16	from	from	IN
cord-291950-9gtsqyfj	468	17	a	a	DT
cord-291950-9gtsqyfj	468	18	polypeptide	polypeptide	NN
cord-291950-9gtsqyfj	468	19	.	.	.
cord-291950-9gtsqyfj	469	1	Cys144	Cys144	.
cord-291950-9gtsqyfj	470	1	and	and	CC
cord-291950-9gtsqyfj	470	2	His166	his166	CD
cord-291950-9gtsqyfj	470	3	have	have	VBP
cord-291950-9gtsqyfj	470	4	been	be	VBN
cord-291950-9gtsqyfj	470	5	identified	identify	VBN
cord-291950-9gtsqyfj	470	6	as	as	IN
cord-291950-9gtsqyfj	470	7	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	470	8	residues	residue	NNS
cord-291950-9gtsqyfj	470	9	[	[	-LRB-
cord-291950-9gtsqyfj	470	10	84	84	CD
cord-291950-9gtsqyfj	470	11	]	]	-RRB-
cord-291950-9gtsqyfj	470	12	.	.	.
cord-291950-9gtsqyfj	471	1	Human	human	JJ
cord-291950-9gtsqyfj	471	2	pyroglutamyl	pyroglutamyl	NN
cord-291950-9gtsqyfj	471	3	-	-	HYPH
cord-291950-9gtsqyfj	471	4	peptidase	peptidase	NN
cord-291950-9gtsqyfj	472	1	I	-PRON-	PRP
cord-291950-9gtsqyfj	472	2	has	have	VBZ
cord-291950-9gtsqyfj	472	3	been	be	VBN
cord-291950-9gtsqyfj	472	4	cloned	clone	VBN
cord-291950-9gtsqyfj	472	5	and	and	CC
cord-291950-9gtsqyfj	472	6	expressed	express	VBN
cord-291950-9gtsqyfj	472	7	[	[	-LRB-
cord-291950-9gtsqyfj	472	8	85	85	CD
cord-291950-9gtsqyfj	472	9	]	]	-RRB-
cord-291950-9gtsqyfj	472	10	;	;	:
cord-291950-9gtsqyfj	473	1	(	(	-LRB-
cord-291950-9gtsqyfj	473	2	Chapter	chapter	NN
cord-291950-9gtsqyfj	473	3	548	548	CD
cord-291950-9gtsqyfj	473	4	)	)	-RRB-
cord-291950-9gtsqyfj	473	5	,	,	,
cord-291950-9gtsqyfj	473	6	and	and	CC
cord-291950-9gtsqyfj	473	7	appears	appear	VBZ
cord-291950-9gtsqyfj	473	8	to	to	TO
cord-291950-9gtsqyfj	473	9	be	be	VB
cord-291950-9gtsqyfj	473	10	structurally	structurally	RB
cord-291950-9gtsqyfj	473	11	very	very	RB
cord-291950-9gtsqyfj	473	12	similar	similar	JJ
cord-291950-9gtsqyfj	473	13	to	to	IN
cord-291950-9gtsqyfj	473	14	the	the	DT
cord-291950-9gtsqyfj	473	15	archaean	archaean	JJ
cord-291950-9gtsqyfj	473	16	and	and	CC
cord-291950-9gtsqyfj	473	17	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	473	18	forms	form	NNS
cord-291950-9gtsqyfj	473	19	of	of	IN
cord-291950-9gtsqyfj	473	20	the	the	DT
cord-291950-9gtsqyfj	473	21	enzyme	enzyme	NN
cord-291950-9gtsqyfj	473	22	.	.	.
cord-291950-9gtsqyfj	474	1	Family	Family	NNP
cord-291950-9gtsqyfj	474	2	C46	C46	NNP
cord-291950-9gtsqyfj	474	3	contains	contain	VBZ
cord-291950-9gtsqyfj	474	4	the	the	DT
cord-291950-9gtsqyfj	474	5	Hedgehog	Hedgehog	NNP
cord-291950-9gtsqyfj	474	6	proteins	protein	NNS
cord-291950-9gtsqyfj	474	7	.	.	.
cord-291950-9gtsqyfj	475	1	The	the	DT
cord-291950-9gtsqyfj	475	2	Hedgehog	Hedgehog	NNP
cord-291950-9gtsqyfj	475	3	proteins	protein	NNS
cord-291950-9gtsqyfj	475	4	are	be	VBP
cord-291950-9gtsqyfj	475	5	formed	form	VBN
cord-291950-9gtsqyfj	475	6	of	of	IN
cord-291950-9gtsqyfj	475	7	two	two	CD
cord-291950-9gtsqyfj	475	8	structural	structural	JJ
cord-291950-9gtsqyfj	475	9	domains	domain	NNS
cord-291950-9gtsqyfj	475	10	,	,	,
cord-291950-9gtsqyfj	475	11	and	and	CC
cord-291950-9gtsqyfj	475	12	the	the	DT
cord-291950-9gtsqyfj	475	13	only	only	JJ
cord-291950-9gtsqyfj	475	14	peptidase	peptidase	NN
cord-291950-9gtsqyfj	475	15	activity	activity	NN
cord-291950-9gtsqyfj	475	16	is	be	VBZ
cord-291950-9gtsqyfj	475	17	an	an	DT
cord-291950-9gtsqyfj	475	18	autolytic	autolytic	JJ
cord-291950-9gtsqyfj	475	19	reaction	reaction	NN
cord-291950-9gtsqyfj	475	20	that	that	WDT
cord-291950-9gtsqyfj	475	21	separates	separate	VBZ
cord-291950-9gtsqyfj	475	22	the	the	DT
cord-291950-9gtsqyfj	475	23	two	two	CD
cord-291950-9gtsqyfj	475	24	domains	domain	NNS
cord-291950-9gtsqyfj	475	25	.	.	.
cord-291950-9gtsqyfj	476	1	The	the	DT
cord-291950-9gtsqyfj	476	2	reaction	reaction	NN
cord-291950-9gtsqyfj	476	3	is	be	VBZ
cord-291950-9gtsqyfj	476	4	cleavage	cleavage	NN
cord-291950-9gtsqyfj	476	5	of	of	IN
cord-291950-9gtsqyfj	476	6	a	a	DT
cord-291950-9gtsqyfj	476	7	conserved	conserved	JJ
cord-291950-9gtsqyfj	476	8	Gly258kCys259	gly258kcys259	JJ
cord-291950-9gtsqyfj	476	9	bond	bond	NN
cord-291950-9gtsqyfj	476	10	,	,	,
cord-291950-9gtsqyfj	476	11	and	and	CC
cord-291950-9gtsqyfj	476	12	a	a	DT
cord-291950-9gtsqyfj	476	13	cholesterol	cholesterol	NN
cord-291950-9gtsqyfj	476	14	moiety	moiety	NN
cord-291950-9gtsqyfj	476	15	is	be	VBZ
cord-291950-9gtsqyfj	476	16	simultaneously	simultaneously	RB
cord-291950-9gtsqyfj	476	17	attached	attach	VBN
cord-291950-9gtsqyfj	476	18	to	to	IN
cord-291950-9gtsqyfj	476	19	the	the	DT
cord-291950-9gtsqyfj	476	20	new	new	JJ
cord-291950-9gtsqyfj	476	21	C	C	NNP
cord-291950-9gtsqyfj	476	22	-	-	HYPH
cord-291950-9gtsqyfj	476	23	terminal	terminal	JJ
cord-291950-9gtsqyfj	476	24	glycyl	glycyl	NN
cord-291950-9gtsqyfj	476	25	residue	residue	NN
cord-291950-9gtsqyfj	476	26	of	of	IN
cord-291950-9gtsqyfj	476	27	the	the	DT
cord-291950-9gtsqyfj	476	28	N	n	CD
cord-291950-9gtsqyfj	476	29	-	-	HYPH
cord-291950-9gtsqyfj	476	30	terminal	terminal	NN
cord-291950-9gtsqyfj	476	31	domain	domain	NN
cord-291950-9gtsqyfj	476	32	.	.	.
cord-291950-9gtsqyfj	477	1	The	the	DT
cord-291950-9gtsqyfj	477	2	18-kDa	18-kda	CD
cord-291950-9gtsqyfj	477	3	Nterminal	Nterminal	NNP
cord-291950-9gtsqyfj	477	4	domain	domain	NN
cord-291950-9gtsqyfj	477	5	is	be	VBZ
cord-291950-9gtsqyfj	477	6	structurally	structurally	RB
cord-291950-9gtsqyfj	477	7	related	relate	VBN
cord-291950-9gtsqyfj	477	8	to	to	IN
cord-291950-9gtsqyfj	477	9	a	a	DT
cord-291950-9gtsqyfj	477	10	zinc	zinc	NN
cord-291950-9gtsqyfj	477	11	D	d	NN
cord-291950-9gtsqyfj	477	12	-	-	HYPH
cord-291950-9gtsqyfj	477	13	Ala	ala	NN
cord-291950-9gtsqyfj	477	14	-	-	HYPH
cord-291950-9gtsqyfj	477	15	D	D	NNP
cord-291950-9gtsqyfj	477	16	-	-	HYPH
cord-291950-9gtsqyfj	477	17	Ala	Ala	NNP
cord-291950-9gtsqyfj	477	18	carboxypeptidase	carboxypeptidase	NN
cord-291950-9gtsqyfj	477	19	in	in	IN
cord-291950-9gtsqyfj	477	20	clan	clan	NN
cord-291950-9gtsqyfj	477	21	MD	MD	NNP
cord-291950-9gtsqyfj	477	22	;	;	:
cord-291950-9gtsqyfj	477	23	it	-PRON-	PRP
cord-291950-9gtsqyfj	477	24	is	be	VBZ
cord-291950-9gtsqyfj	477	25	not	not	RB
cord-291950-9gtsqyfj	477	26	known	know	VBN
cord-291950-9gtsqyfj	477	27	to	to	TO
cord-291950-9gtsqyfj	477	28	have	have	VB
cord-291950-9gtsqyfj	477	29	any	any	DT
cord-291950-9gtsqyfj	477	30	peptidase	peptidase	NN
cord-291950-9gtsqyfj	477	31	activity	activity	NN
cord-291950-9gtsqyfj	477	32	but	but	CC
cord-291950-9gtsqyfj	477	33	has	have	VBZ
cord-291950-9gtsqyfj	477	34	a	a	DT
cord-291950-9gtsqyfj	477	35	function	function	NN
cord-291950-9gtsqyfj	477	36	in	in	IN
cord-291950-9gtsqyfj	477	37	the	the	DT
cord-291950-9gtsqyfj	477	38	embryological	embryological	JJ
cord-291950-9gtsqyfj	477	39	development	development	NN
cord-291950-9gtsqyfj	477	40	of	of	IN
cord-291950-9gtsqyfj	477	41	dorsal	dorsal	JJ
cord-291950-9gtsqyfj	477	42	-	-	HYPH
cord-291950-9gtsqyfj	477	43	ventral	ventral	JJ
cord-291950-9gtsqyfj	477	44	patterning	patterning	NN
cord-291950-9gtsqyfj	477	45	.	.	.
cord-291950-9gtsqyfj	478	1	Mutational	Mutational	NNP
cord-291950-9gtsqyfj	478	2	studies	study	NNS
cord-291950-9gtsqyfj	478	3	have	have	VBP
cord-291950-9gtsqyfj	478	4	shown	show	VBN
cord-291950-9gtsqyfj	478	5	that	that	IN
cord-291950-9gtsqyfj	478	6	residues	residue	NNS
cord-291950-9gtsqyfj	478	7	Cys258	cys258	CD
cord-291950-9gtsqyfj	478	8	and	and	CC
cord-291950-9gtsqyfj	478	9	His329	his329	NN
cord-291950-9gtsqyfj	478	10	in	in	IN
cord-291950-9gtsqyfj	478	11	the	the	DT
cord-291950-9gtsqyfj	478	12	25-kDa	25-kda	CD
cord-291950-9gtsqyfj	478	13	C	c	NN
cord-291950-9gtsqyfj	478	14	-	-	HYPH
cord-291950-9gtsqyfj	478	15	terminal	terminal	NN
cord-291950-9gtsqyfj	478	16	domain	domain	NN
cord-291950-9gtsqyfj	478	17	are	be	VBP
cord-291950-9gtsqyfj	478	18	essential	essential	JJ
cord-291950-9gtsqyfj	478	19	for	for	IN
cord-291950-9gtsqyfj	478	20	the	the	DT
cord-291950-9gtsqyfj	478	21	autolytic	autolytic	JJ
cord-291950-9gtsqyfj	478	22	cleavage	cleavage	NN
cord-291950-9gtsqyfj	478	23	[	[	-LRB-
cord-291950-9gtsqyfj	478	24	86	86	CD
cord-291950-9gtsqyfj	478	25	]	]	-RRB-
cord-291950-9gtsqyfj	478	26	.	.	.
cord-291950-9gtsqyfj	479	1	The	the	DT
cord-291950-9gtsqyfj	479	2	reaction	reaction	NN
cord-291950-9gtsqyfj	479	3	is	be	VBZ
cord-291950-9gtsqyfj	479	4	not	not	RB
cord-291950-9gtsqyfj	479	5	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	479	6	by	by	IN
cord-291950-9gtsqyfj	479	7	any	any	DT
cord-291950-9gtsqyfj	479	8	standard	standard	JJ
cord-291950-9gtsqyfj	479	9	peptidase	peptidase	NN
cord-291950-9gtsqyfj	479	10	inhibitors	inhibitor	NNS
cord-291950-9gtsqyfj	479	11	,	,	,
cord-291950-9gtsqyfj	479	12	but	but	CC
cord-291950-9gtsqyfj	479	13	requires	require	VBZ
cord-291950-9gtsqyfj	479	14	DTT	DTT	NNP
cord-291950-9gtsqyfj	479	15	in	in	IN
cord-291950-9gtsqyfj	479	16	vitro	vitro	FW
cord-291950-9gtsqyfj	479	17	.	.	.
cord-291950-9gtsqyfj	480	1	The	the	DT
cord-291950-9gtsqyfj	480	2	cleavage	cleavage	NN
cord-291950-9gtsqyfj	480	3	mechanism	mechanism	NN
cord-291950-9gtsqyfj	480	4	is	be	VBZ
cord-291950-9gtsqyfj	480	5	believed	believe	VBN
cord-291950-9gtsqyfj	480	6	to	to	TO
cord-291950-9gtsqyfj	480	7	be	be	VB
cord-291950-9gtsqyfj	480	8	similar	similar	JJ
cord-291950-9gtsqyfj	480	9	to	to	IN
cord-291950-9gtsqyfj	480	10	that	that	DT
cord-291950-9gtsqyfj	480	11	of	of	IN
cord-291950-9gtsqyfj	480	12	the	the	DT
cord-291950-9gtsqyfj	480	13	activation	activation	NN
cord-291950-9gtsqyfj	480	14	of	of	IN
cord-291950-9gtsqyfj	480	15	prohistidine	prohistidine	JJ
cord-291950-9gtsqyfj	480	16	decarboxylase	decarboxylase	NN
cord-291950-9gtsqyfj	480	17	[	[	-LRB-
cord-291950-9gtsqyfj	480	18	87	87	CD
cord-291950-9gtsqyfj	480	19	]	]	-RRB-
cord-291950-9gtsqyfj	480	20	,	,	,
cord-291950-9gtsqyfj	480	21	involving	involve	VBG
cord-291950-9gtsqyfj	480	22	activation	activation	NN
cord-291950-9gtsqyfj	480	23	of	of	IN
cord-291950-9gtsqyfj	480	24	Cys258	cys258	CD
cord-291950-9gtsqyfj	480	25	by	by	IN
cord-291950-9gtsqyfj	480	26	His329	His329	NNS
cord-291950-9gtsqyfj	480	27	for	for	IN
cord-291950-9gtsqyfj	480	28	a	a	DT
cord-291950-9gtsqyfj	480	29	nucleophilic	nucleophilic	JJ
cord-291950-9gtsqyfj	480	30	attack	attack	NN
cord-291950-9gtsqyfj	480	31	on	on	IN
cord-291950-9gtsqyfj	480	32	the	the	DT
cord-291950-9gtsqyfj	480	33	carbonyl	carbonyl	NN
cord-291950-9gtsqyfj	480	34	of	of	IN
cord-291950-9gtsqyfj	480	35	Gly257	Gly257	NNS
cord-291950-9gtsqyfj	480	36	.	.	.
cord-291950-9gtsqyfj	481	1	There	there	EX
cord-291950-9gtsqyfj	481	2	is	be	VBZ
cord-291950-9gtsqyfj	481	3	a	a	DT
cord-291950-9gtsqyfj	481	4	motif	motif	NN
cord-291950-9gtsqyfj	481	5	around	around	IN
cord-291950-9gtsqyfj	481	6	the	the	DT
cord-291950-9gtsqyfj	481	7	cleavage	cleavage	NN
cord-291950-9gtsqyfj	481	8	site	site	NN
cord-291950-9gtsqyfj	481	9	that	that	WDT
cord-291950-9gtsqyfj	481	10	is	be	VBZ
cord-291950-9gtsqyfj	481	11	similar	similar	JJ
cord-291950-9gtsqyfj	481	12	to	to	IN
cord-291950-9gtsqyfj	481	13	that	that	DT
cord-291950-9gtsqyfj	481	14	found	find	VBN
cord-291950-9gtsqyfj	481	15	at	at	IN
cord-291950-9gtsqyfj	481	16	the	the	DT
cord-291950-9gtsqyfj	481	17	N	n	CD
cord-291950-9gtsqyfj	481	18	-	-	HYPH
cord-291950-9gtsqyfj	481	19	terminal	terminal	JJ
cord-291950-9gtsqyfj	481	20	splice	splice	NN
cord-291950-9gtsqyfj	481	21	junction	junction	NN
cord-291950-9gtsqyfj	481	22	of	of	IN
cord-291950-9gtsqyfj	481	23	self	self	NN
cord-291950-9gtsqyfj	481	24	-	-	HYPH
cord-291950-9gtsqyfj	481	25	splicing	splice	VBG
cord-291950-9gtsqyfj	481	26	proteins	protein	NNS
cord-291950-9gtsqyfj	481	27	(	(	-LRB-
cord-291950-9gtsqyfj	481	28	Chapter	chapter	NN
cord-291950-9gtsqyfj	481	29	76	76	CD
cord-291950-9gtsqyfj	481	30	)	)	-RRB-
cord-291950-9gtsqyfj	481	31	,	,	,
cord-291950-9gtsqyfj	481	32	and	and	CC
cord-291950-9gtsqyfj	481	33	splicing	splicing	NN
cord-291950-9gtsqyfj	481	34	may	may	MD
cord-291950-9gtsqyfj	481	35	involve	involve	VB
cord-291950-9gtsqyfj	481	36	a	a	DT
cord-291950-9gtsqyfj	481	37	thioester	thioester	NN
cord-291950-9gtsqyfj	481	38	intermediate	intermediate	JJ
cord-291950-9gtsqyfj	481	39	[	[	-LRB-
cord-291950-9gtsqyfj	481	40	88	88	CD
cord-291950-9gtsqyfj	481	41	]	]	-RRB-
cord-291950-9gtsqyfj	481	42	.	.	.
cord-291950-9gtsqyfj	482	1	The	the	DT
cord-291950-9gtsqyfj	482	2	crystal	crystal	JJ
cord-291950-9gtsqyfj	482	3	structure	structure	NN
cord-291950-9gtsqyfj	482	4	of	of	IN
cord-291950-9gtsqyfj	482	5	the	the	DT
cord-291950-9gtsqyfj	482	6	Sonic	sonic	JJ
cord-291950-9gtsqyfj	482	7	hedgehog	hedgehog	NN
cord-291950-9gtsqyfj	482	8	C	c	NN
cord-291950-9gtsqyfj	482	9	-	-	HYPH
cord-291950-9gtsqyfj	482	10	terminal	terminal	NN
cord-291950-9gtsqyfj	482	11	domain	domain	NN
cord-291950-9gtsqyfj	482	12	(	(	-LRB-
cord-291950-9gtsqyfj	482	13	Figure	figure	NN
cord-291950-9gtsqyfj	482	14	404	404	CD
cord-291950-9gtsqyfj	482	15	.32	.32	NFP
cord-291950-9gtsqyfj	482	16	)	)	-RRB-
cord-291950-9gtsqyfj	482	17	shows	show	VBZ
cord-291950-9gtsqyfj	482	18	that	that	IN
cord-291950-9gtsqyfj	482	19	it	-PRON-	PRP
cord-291950-9gtsqyfj	482	20	consists	consist	VBZ
cord-291950-9gtsqyfj	482	21	of	of	IN
cord-291950-9gtsqyfj	482	22	two	two	CD
cord-291950-9gtsqyfj	482	23	tandem	tandem	JJ
cord-291950-9gtsqyfj	482	24	intein	intein	NNP
cord-291950-9gtsqyfj	482	25	-	-	HYPH
cord-291950-9gtsqyfj	482	26	like	like	JJ
cord-291950-9gtsqyfj	482	27	repeats	repeat	VBZ
cord-291950-9gtsqyfj	482	28	[	[	-LRB-
cord-291950-9gtsqyfj	482	29	89	89	CD
cord-291950-9gtsqyfj	482	30	]	]	-RRB-
cord-291950-9gtsqyfj	482	31	,	,	,
cord-291950-9gtsqyfj	482	32	and	and	CC
cord-291950-9gtsqyfj	483	1	family	family	NN
cord-291950-9gtsqyfj	483	2	C46	C46	NNP
cord-291950-9gtsqyfj	483	3	is	be	VBZ
cord-291950-9gtsqyfj	483	4	now	now	RB
cord-291950-9gtsqyfj	483	5	included	include	VBN
cord-291950-9gtsqyfj	483	6	in	in	IN
cord-291950-9gtsqyfj	483	7	a	a	DT
cord-291950-9gtsqyfj	483	8	clan	clan	NN
cord-291950-9gtsqyfj	483	9	of	of	IN
cord-291950-9gtsqyfj	483	10	mixed	mixed	JJ
cord-291950-9gtsqyfj	483	11	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	483	12	types	type	NNS
cord-291950-9gtsqyfj	483	13	,	,	,
cord-291950-9gtsqyfj	483	14	PD	PD	NNP
cord-291950-9gtsqyfj	483	15	,	,	,
cord-291950-9gtsqyfj	483	16	along	along	IN
cord-291950-9gtsqyfj	483	17	with	with	IN
cord-291950-9gtsqyfj	483	18	the	the	DT
cord-291950-9gtsqyfj	483	19	three	three	CD
cord-291950-9gtsqyfj	483	20	intein	intein	NNP
cord-291950-9gtsqyfj	483	21	families	family	NNS
cord-291950-9gtsqyfj	483	22	(	(	-LRB-
cord-291950-9gtsqyfj	483	23	see	see	VB
cord-291950-9gtsqyfj	483	24	Chapter	chapter	NN
cord-291950-9gtsqyfj	483	25	76	76	CD
cord-291950-9gtsqyfj	483	26	)	)	-RRB-
cord-291950-9gtsqyfj	484	1	[	[	-LRB-
cord-291950-9gtsqyfj	484	2	90	90	CD
cord-291950-9gtsqyfj	484	3	]	]	-RRB-
cord-291950-9gtsqyfj	484	4	.	.	.
cord-291950-9gtsqyfj	485	1	Peptidases	Peptidases	NNP
cord-291950-9gtsqyfj	485	2	within	within	IN
cord-291950-9gtsqyfj	485	3	clan	clan	NN
cord-291950-9gtsqyfj	485	4	CL	CL	NNP
cord-291950-9gtsqyfj	485	5	have	have	VBP
cord-291950-9gtsqyfj	485	6	active	active	JJ
cord-291950-9gtsqyfj	485	7	site	site	NN
cord-291950-9gtsqyfj	485	8	residues	residue	NNS
cord-291950-9gtsqyfj	485	9	in	in	IN
cord-291950-9gtsqyfj	485	10	the	the	DT
cord-291950-9gtsqyfj	485	11	order	order	NN
cord-291950-9gtsqyfj	485	12	His	-PRON-	PRP$
cord-291950-9gtsqyfj	485	13	,	,	,
cord-291950-9gtsqyfj	485	14	Cys	Cys	NNP
cord-291950-9gtsqyfj	485	15	in	in	IN
cord-291950-9gtsqyfj	485	16	the	the	DT
cord-291950-9gtsqyfj	485	17	sequence	sequence	NN
cord-291950-9gtsqyfj	485	18	,	,	,
cord-291950-9gtsqyfj	485	19	and	and	CC
cord-291950-9gtsqyfj	485	20	a	a	DT
cord-291950-9gtsqyfj	485	21	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	485	22	fold	fold	NN
cord-291950-9gtsqyfj	485	23	consisting	consisting	NN
cord-291950-9gtsqyfj	485	24	of	of	IN
cord-291950-9gtsqyfj	485	25	a	a	DT
cord-291950-9gtsqyfj	485	26	closed	closed	JJ
cord-291950-9gtsqyfj	485	27	β	β	NN
cord-291950-9gtsqyfj	485	28	-	-	HYPH
cord-291950-9gtsqyfj	485	29	barrel	barrel	NN
cord-291950-9gtsqyfj	485	30	surrounded	surround	VBN
cord-291950-9gtsqyfj	485	31	by	by	IN
cord-291950-9gtsqyfj	485	32	helices	helix	NNS
cord-291950-9gtsqyfj	485	33	(	(	-LRB-
cord-291950-9gtsqyfj	485	34	see	see	VB
cord-291950-9gtsqyfj	485	35	Figure	Figure	NNP
cord-291950-9gtsqyfj	485	36	404	404	CD
cord-291950-9gtsqyfj	485	37	.33	.33	CD
cord-291950-9gtsqyfj	485	38	)	)	-RRB-
cord-291950-9gtsqyfj	485	39	.	.	.
cord-291950-9gtsqyfj	486	1	The	the	DT
cord-291950-9gtsqyfj	486	2	active	active	JJ
cord-291950-9gtsqyfj	486	3	site	site	NN
cord-291950-9gtsqyfj	486	4	is	be	VBZ
cord-291950-9gtsqyfj	486	5	at	at	IN
cord-291950-9gtsqyfj	486	6	the	the	DT
cord-291950-9gtsqyfj	486	7	end	end	NN
cord-291950-9gtsqyfj	486	8	of	of	IN
cord-291950-9gtsqyfj	486	9	the	the	DT
cord-291950-9gtsqyfj	486	10	barrel	barrel	NN
cord-291950-9gtsqyfj	486	11	.	.	.
cord-291950-9gtsqyfj	487	1	The	the	DT
cord-291950-9gtsqyfj	487	2	fold	fold	NN
cord-291950-9gtsqyfj	487	3	is	be	VBZ
cord-291950-9gtsqyfj	487	4	similar	similar	JJ
cord-291950-9gtsqyfj	487	5	to	to	IN
cord-291950-9gtsqyfj	487	6	that	that	DT
cord-291950-9gtsqyfj	487	7	of	of	IN
cord-291950-9gtsqyfj	487	8	the	the	DT
cord-291950-9gtsqyfj	487	9	ykuD	ykud	NN
cord-291950-9gtsqyfj	487	10	transpeptidase	transpeptidase	NN
cord-291950-9gtsqyfj	487	11	from	from	IN
cord-291950-9gtsqyfj	487	12	Bacillus	bacillus	NN
cord-291950-9gtsqyfj	487	13	subtilis	subtili	NNS
cord-291950-9gtsqyfj	487	14	[	[	-LRB-
cord-291950-9gtsqyfj	487	15	91	91	CD
cord-291950-9gtsqyfj	487	16	]	]	-RRB-
cord-291950-9gtsqyfj	487	17	.	.	.
cord-291950-9gtsqyfj	488	1	Members	member	NNS
cord-291950-9gtsqyfj	488	2	of	of	IN
cord-291950-9gtsqyfj	488	3	the	the	DT
cord-291950-9gtsqyfj	488	4	clan	clan	NN
cord-291950-9gtsqyfj	488	5	are	be	VBP
cord-291950-9gtsqyfj	488	6	involved	involve	VBN
cord-291950-9gtsqyfj	488	7	in	in	IN
cord-291950-9gtsqyfj	488	8	hydrolysis	hydrolysis	NN
cord-291950-9gtsqyfj	488	9	of	of	IN
cord-291950-9gtsqyfj	488	10	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	488	11	cell	cell	NN
cord-291950-9gtsqyfj	488	12	wall	wall	NN
cord-291950-9gtsqyfj	488	13	peptides	peptide	NNS
cord-291950-9gtsqyfj	488	14	.	.	.
cord-291950-9gtsqyfj	489	1	Family	Family	NNP
cord-291950-9gtsqyfj	489	2	C60	C60	NNP
cord-291950-9gtsqyfj	489	3	includes	include	VBZ
cord-291950-9gtsqyfj	489	4	peptidases	peptidases	NNP
cord-291950-9gtsqyfj	489	5	known	know	VBN
cord-291950-9gtsqyfj	489	6	as	as	IN
cord-291950-9gtsqyfj	489	7	sortases	sortases	NNPS
cord-291950-9gtsqyfj	489	8	(	(	-LRB-
cord-291950-9gtsqyfj	489	9	Chapter	chapter	NN
cord-291950-9gtsqyfj	489	10	551	551	CD
cord-291950-9gtsqyfj	489	11	)	)	-RRB-
cord-291950-9gtsqyfj	489	12	from	from	IN
cord-291950-9gtsqyfj	489	13	Gram	gram	NN
cord-291950-9gtsqyfj	489	14	-	-	HYPH
cord-291950-9gtsqyfj	489	15	positive	positive	JJ
cord-291950-9gtsqyfj	489	16	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	489	17	,	,	,
cord-291950-9gtsqyfj	489	18	and	and	CC
cord-291950-9gtsqyfj	489	19	sortase	sortase	NNP
cord-291950-9gtsqyfj	489	20	A	a	NN
cord-291950-9gtsqyfj	489	21	from	from	IN
cord-291950-9gtsqyfj	489	22	Staphylococcus	Staphylococcus	NNP
cord-291950-9gtsqyfj	489	23	aureus	aureus	NN
cord-291950-9gtsqyfj	489	24	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	489	25	proteins	protein	NNS
cord-291950-9gtsqyfj	489	26	at	at	IN
cord-291950-9gtsqyfj	489	27	a	a	DT
cord-291950-9gtsqyfj	489	28	Leu	Leu	NNP
cord-291950-9gtsqyfj	489	29	-	-	HYPH
cord-291950-9gtsqyfj	489	30	Pro	Pro	NNP
cord-291950-9gtsqyfj	489	31	-	-	HYPH
cord-291950-9gtsqyfj	489	32	Xaa	Xaa	NNP
cord-291950-9gtsqyfj	489	33	-	-	HYPH
cord-291950-9gtsqyfj	489	34	ThrkGly	ThrkGly	NNP
cord-291950-9gtsqyfj	489	35	motif	motif	NN
cord-291950-9gtsqyfj	489	36	,	,	,
cord-291950-9gtsqyfj	489	37	and	and	CC
cord-291950-9gtsqyfj	489	38	then	then	RB
cord-291950-9gtsqyfj	489	39	catalyzes	catalyze	VBZ
cord-291950-9gtsqyfj	489	40	the	the	DT
cord-291950-9gtsqyfj	489	41	formation	formation	NN
cord-291950-9gtsqyfj	489	42	of	of	IN
cord-291950-9gtsqyfj	489	43	an	an	DT
cord-291950-9gtsqyfj	489	44	amide	amide	NN
cord-291950-9gtsqyfj	489	45	bond	bond	NN
cord-291950-9gtsqyfj	489	46	between	between	IN
cord-291950-9gtsqyfj	489	47	the	the	DT
cord-291950-9gtsqyfj	489	48	newly	newly	RB
cord-291950-9gtsqyfj	489	49	exposed	expose	VBN
cord-291950-9gtsqyfj	489	50	C	c	NN
cord-291950-9gtsqyfj	489	51	-	-	HYPH
cord-291950-9gtsqyfj	489	52	terminal	terminal	NN
cord-291950-9gtsqyfj	489	53	Thr	Thr	NNP
cord-291950-9gtsqyfj	489	54	and	and	CC
cord-291950-9gtsqyfj	489	55	the	the	DT
cord-291950-9gtsqyfj	489	56	cross	cross	NN
cord-291950-9gtsqyfj	489	57	-	-	JJ
cord-291950-9gtsqyfj	489	58	linking	link	VBG
cord-291950-9gtsqyfj	489	59	pentapeptide	pentapeptide	NN
cord-291950-9gtsqyfj	489	60	of	of	IN
cord-291950-9gtsqyfj	489	61	the	the	DT
cord-291950-9gtsqyfj	489	62	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	489	63	cell	cell	NN
cord-291950-9gtsqyfj	489	64	wall	wall	NN
cord-291950-9gtsqyfj	489	65	[	[	-LRB-
cord-291950-9gtsqyfj	489	66	91	91	CD
cord-291950-9gtsqyfj	489	67	]	]	-RRB-
cord-291950-9gtsqyfj	489	68	.	.	.
cord-291950-9gtsqyfj	490	1	The	the	DT
cord-291950-9gtsqyfj	490	2	proteins	protein	NNS
cord-291950-9gtsqyfj	490	3	that	that	WDT
cord-291950-9gtsqyfj	490	4	are	be	VBP
cord-291950-9gtsqyfj	490	5	attached	attach	VBN
cord-291950-9gtsqyfj	490	6	in	in	IN
cord-291950-9gtsqyfj	490	7	this	this	DT
cord-291950-9gtsqyfj	490	8	way	way	NN
cord-291950-9gtsqyfj	490	9	to	to	IN
cord-291950-9gtsqyfj	490	10	the	the	DT
cord-291950-9gtsqyfj	490	11	exterior	exterior	NN
cord-291950-9gtsqyfj	490	12	of	of	IN
cord-291950-9gtsqyfj	490	13	the	the	DT
cord-291950-9gtsqyfj	490	14	cell	cell	NN
cord-291950-9gtsqyfj	490	15	wall	wall	NN
cord-291950-9gtsqyfj	490	16	can	can	MD
cord-291950-9gtsqyfj	490	17	be	be	VB
cord-291950-9gtsqyfj	490	18	virulence	virulence	NN
cord-291950-9gtsqyfj	490	19	factors	factor	NNS
cord-291950-9gtsqyfj	490	20	,	,	,
cord-291950-9gtsqyfj	490	21	and	and	CC
cord-291950-9gtsqyfj	490	22	inhibition	inhibition	NN
cord-291950-9gtsqyfj	490	23	of	of	IN
cord-291950-9gtsqyfj	490	24	sortases	sortase	NNS
cord-291950-9gtsqyfj	490	25	has	have	VBZ
cord-291950-9gtsqyfj	490	26	been	be	VBN
cord-291950-9gtsqyfj	490	27	shown	show	VBN
cord-291950-9gtsqyfj	490	28	to	to	TO
cord-291950-9gtsqyfj	490	29	decrease	decrease	VB
cord-291950-9gtsqyfj	490	30	virulence	virulence	NN
cord-291950-9gtsqyfj	490	31	.	.	.
cord-291950-9gtsqyfj	491	1	Surprisingly	surprisingly	RB
cord-291950-9gtsqyfj	491	2	,	,	,
cord-291950-9gtsqyfj	491	3	given	give	VBN
cord-291950-9gtsqyfj	491	4	a	a	DT
cord-291950-9gtsqyfj	491	5	lack	lack	NN
cord-291950-9gtsqyfj	491	6	of	of	IN
cord-291950-9gtsqyfj	491	7	structural	structural	JJ
cord-291950-9gtsqyfj	491	8	relationship	relationship	NN
cord-291950-9gtsqyfj	491	9	to	to	IN
cord-291950-9gtsqyfj	491	10	members	member	NNS
cord-291950-9gtsqyfj	491	11	of	of	IN
cord-291950-9gtsqyfj	491	12	clan	clan	NN
cord-291950-9gtsqyfj	491	13	CA	CA	NNP
cord-291950-9gtsqyfj	491	14	,	,	,
cord-291950-9gtsqyfj	491	15	sortases	sortase	NNS
cord-291950-9gtsqyfj	491	16	are	be	VBP
cord-291950-9gtsqyfj	491	17	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	491	18	by	by	IN
cord-291950-9gtsqyfj	491	19	E-64	E-64	NNP
cord-291950-9gtsqyfj	491	20	.	.	.
cord-291950-9gtsqyfj	492	1	The	the	DT
cord-291950-9gtsqyfj	492	2	evolutionary	evolutionary	JJ
cord-291950-9gtsqyfj	492	3	tree	tree	NN
cord-291950-9gtsqyfj	492	4	shows	show	VBZ
cord-291950-9gtsqyfj	492	5	a	a	DT
cord-291950-9gtsqyfj	492	6	deep	deep	JJ
cord-291950-9gtsqyfj	492	7	divergence	divergence	NN
cord-291950-9gtsqyfj	492	8	within	within	IN
cord-291950-9gtsqyfj	492	9	the	the	DT
cord-291950-9gtsqyfj	492	10	family	family	NN
cord-291950-9gtsqyfj	492	11	,	,	,
cord-291950-9gtsqyfj	492	12	which	which	WDT
cord-291950-9gtsqyfj	492	13	is	be	VBZ
cord-291950-9gtsqyfj	492	14	divided	divide	VBN
cord-291950-9gtsqyfj	492	15	into	into	IN
cord-291950-9gtsqyfj	492	16	two	two	CD
cord-291950-9gtsqyfj	492	17	subfamilies	subfamily	NNS
cord-291950-9gtsqyfj	492	18	.	.	.
cord-291950-9gtsqyfj	493	1	Subfamily	Subfamily	NNP
cord-291950-9gtsqyfj	493	2	C60A	C60A	NNP
cord-291950-9gtsqyfj	493	3	includes	include	VBZ
cord-291950-9gtsqyfj	493	4	sortase	sortase	NNP
cord-291950-9gtsqyfj	493	5	A	A	NNP
cord-291950-9gtsqyfj	493	6	,	,	,
cord-291950-9gtsqyfj	493	7	whereas	whereas	IN
cord-291950-9gtsqyfj	493	8	C60B	c60b	NN
cord-291950-9gtsqyfj	493	9	includes	include	VBZ
cord-291950-9gtsqyfj	493	10	sortase	sortase	NNP
cord-291950-9gtsqyfj	493	11	B.	B.	NNP
cord-291950-9gtsqyfj	493	12	Sortase	Sortase	NNP
cord-291950-9gtsqyfj	493	13	B	B	NNP
cord-291950-9gtsqyfj	493	14	,	,	,
cord-291950-9gtsqyfj	493	15	also	also	RB
cord-291950-9gtsqyfj	493	16	from	from	IN
cord-291950-9gtsqyfj	493	17	Staphylococcus	Staphylococcus	NNP
cord-291950-9gtsqyfj	493	18	aureus	aureus	NN
cord-291950-9gtsqyfj	493	19	,	,	,
cord-291950-9gtsqyfj	493	20	recognizes	recognize	VBZ
cord-291950-9gtsqyfj	493	21	a	a	DT
cord-291950-9gtsqyfj	493	22	different	different	JJ
cord-291950-9gtsqyfj	493	23	cleavage	cleavage	NN
cord-291950-9gtsqyfj	493	24	motif	motif	NN
cord-291950-9gtsqyfj	493	25	to	to	IN
cord-291950-9gtsqyfj	493	26	that	that	DT
cord-291950-9gtsqyfj	493	27	of	of	IN
cord-291950-9gtsqyfj	493	28	sortase	sortase	NNP
cord-291950-9gtsqyfj	493	29	A	A	NNP
cord-291950-9gtsqyfj	493	30	[	[	-LRB-
cord-291950-9gtsqyfj	493	31	92	92	CD
cord-291950-9gtsqyfj	493	32	]	]	-RRB-
cord-291950-9gtsqyfj	493	33	.	.	.
cord-291950-9gtsqyfj	494	1	The	the	DT
cord-291950-9gtsqyfj	494	2	only	only	JJ
cord-291950-9gtsqyfj	494	3	other	other	JJ
cord-291950-9gtsqyfj	494	4	family	family	NN
cord-291950-9gtsqyfj	494	5	in	in	IN
cord-291950-9gtsqyfj	494	6	clan	clan	NN
cord-291950-9gtsqyfj	494	7	CL	CL	NNP
cord-291950-9gtsqyfj	494	8	is	be	VBZ
cord-291950-9gtsqyfj	494	9	C82	C82	NNP
cord-291950-9gtsqyfj	494	10	.	.	.
cord-291950-9gtsqyfj	495	1	This	this	DT
cord-291950-9gtsqyfj	495	2	also	also	RB
cord-291950-9gtsqyfj	495	3	includes	include	VBZ
cord-291950-9gtsqyfj	495	4	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	495	5	involved	involve	VBN
cord-291950-9gtsqyfj	495	6	in	in	IN
cord-291950-9gtsqyfj	495	7	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	495	8	cell	cell	NN
cord-291950-9gtsqyfj	495	9	wall	wall	NN
cord-291950-9gtsqyfj	495	10	metabolism	metabolism	NN
cord-291950-9gtsqyfj	495	11	.	.	.
cord-291950-9gtsqyfj	496	1	The	the	DT
cord-291950-9gtsqyfj	496	2	L	l	NN
cord-291950-9gtsqyfj	496	3	,	,	,
cord-291950-9gtsqyfj	496	4	D	D	NNP
cord-291950-9gtsqyfj	496	5	-	-	HYPH
cord-291950-9gtsqyfj	496	6	transpeptidase	transpeptidase	NN
cord-291950-9gtsqyfj	496	7	from	from	IN
cord-291950-9gtsqyfj	496	8	Enterococcus	Enterococcus	NNP
cord-291950-9gtsqyfj	496	9	faecium	faecium	NN
cord-291950-9gtsqyfj	496	10	(	(	-LRB-
cord-291950-9gtsqyfj	496	11	Chapter	chapter	NN
cord-291950-9gtsqyfj	496	12	552	552	CD
cord-291950-9gtsqyfj	496	13	)	)	-RRB-
cord-291950-9gtsqyfj	496	14	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	496	15	the	the	DT
cord-291950-9gtsqyfj	496	16	L	L	NNP
cord-291950-9gtsqyfj	496	17	-	-	HYPH
cord-291950-9gtsqyfj	496	18	LyskD	LyskD	NNP
cord-291950-9gtsqyfj	496	19	-	-	HYPH
cord-291950-9gtsqyfj	496	20	Ala	Ala	NNP
cord-291950-9gtsqyfj	496	21	bonds	bond	NNS
cord-291950-9gtsqyfj	496	22	from	from	IN
cord-291950-9gtsqyfj	496	23	the	the	DT
cord-291950-9gtsqyfj	496	24	crosslinking	crosslinke	VBG
cord-291950-9gtsqyfj	496	25	tetra	tetra	NN
cord-291950-9gtsqyfj	496	26	-	-	HYPH
cord-291950-9gtsqyfj	496	27	and	and	CC
cord-291950-9gtsqyfj	496	28	pentapeptides	pentapeptide	NNS
cord-291950-9gtsqyfj	496	29	,	,	,
cord-291950-9gtsqyfj	496	30	and	and	CC
cord-291950-9gtsqyfj	496	31	also	also	RB
cord-291950-9gtsqyfj	496	32	possesses	possess	VBZ
cord-291950-9gtsqyfj	496	33	cell	cell	NN
cord-291950-9gtsqyfj	496	34	-	-	HYPH
cord-291950-9gtsqyfj	496	35	wall	wall	NN
cord-291950-9gtsqyfj	496	36	crosslinking	crosslinking	NN
cord-291950-9gtsqyfj	496	37	activity	activity	NN
cord-291950-9gtsqyfj	496	38	[	[	-LRB-
cord-291950-9gtsqyfj	496	39	93	93	CD
cord-291950-9gtsqyfj	496	40	]	]	-RRB-
cord-291950-9gtsqyfj	496	41	.	.	.
cord-291950-9gtsqyfj	497	1	The	the	DT
cord-291950-9gtsqyfj	497	2	structure	structure	NN
cord-291950-9gtsqyfj	497	3	of	of	IN
cord-291950-9gtsqyfj	497	4	a	a	DT
cord-291950-9gtsqyfj	497	5	fragment	fragment	NN
cord-291950-9gtsqyfj	497	6	of	of	IN
cord-291950-9gtsqyfj	497	7	the	the	DT
cord-291950-9gtsqyfj	497	8	peptidase	peptidase	NN
cord-291950-9gtsqyfj	497	9	has	have	VBZ
cord-291950-9gtsqyfj	497	10	been	be	VBN
cord-291950-9gtsqyfj	497	11	solved	solve	VBN
cord-291950-9gtsqyfj	497	12	and	and	CC
cord-291950-9gtsqyfj	497	13	shows	show	VBZ
cord-291950-9gtsqyfj	497	14	a	a	DT
cord-291950-9gtsqyfj	497	15	fold	fold	NN
cord-291950-9gtsqyfj	497	16	similar	similar	JJ
cord-291950-9gtsqyfj	497	17	to	to	IN
cord-291950-9gtsqyfj	497	18	that	that	DT
cord-291950-9gtsqyfj	497	19	of	of	IN
cord-291950-9gtsqyfj	497	20	sortases	sortase	NNS
cord-291950-9gtsqyfj	497	21	[	[	-LRB-
cord-291950-9gtsqyfj	497	22	94	94	CD
cord-291950-9gtsqyfj	497	23	]	]	-RRB-
cord-291950-9gtsqyfj	497	24	.	.	.
cord-291950-9gtsqyfj	498	1	The	the	DT
cord-291950-9gtsqyfj	498	2	hepatitis	hepatitis	NN
cord-291950-9gtsqyfj	498	3	C	C	NNP
cord-291950-9gtsqyfj	498	4	polyprotein	polyprotein	NNP
cord-291950-9gtsqyfj	498	5	is	be	VBZ
cord-291950-9gtsqyfj	498	6	processed	process	VBN
cord-291950-9gtsqyfj	498	7	by	by	IN
cord-291950-9gtsqyfj	498	8	virally	virally	RB
cord-291950-9gtsqyfj	498	9	encoded	encode	VBN
cord-291950-9gtsqyfj	498	10	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	498	11	as	as	RB
cord-291950-9gtsqyfj	498	12	well	well	RB
cord-291950-9gtsqyfj	498	13	as	as	IN
cord-291950-9gtsqyfj	498	14	by	by	IN
cord-291950-9gtsqyfj	498	15	host	host	NN
cord-291950-9gtsqyfj	498	16	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	498	17	.	.	.
cord-291950-9gtsqyfj	499	1	Most	Most	JJS
cord-291950-9gtsqyfj	499	2	of	of	IN
cord-291950-9gtsqyfj	499	3	the	the	DT
cord-291950-9gtsqyfj	499	4	cleavages	cleavage	NNS
cord-291950-9gtsqyfj	499	5	are	be	VBP
cord-291950-9gtsqyfj	499	6	performed	perform	VBN
cord-291950-9gtsqyfj	499	7	by	by	IN
cord-291950-9gtsqyfj	499	8	hepacivirin	hepacivirin	NNP
cord-291950-9gtsqyfj	499	9	(	(	-LRB-
cord-291950-9gtsqyfj	499	10	Chapter	chapter	NN
cord-291950-9gtsqyfj	499	11	688	688	CD
cord-291950-9gtsqyfj	499	12	)	)	-RRB-
cord-291950-9gtsqyfj	499	13	,	,	,
cord-291950-9gtsqyfj	499	14	which	which	WDT
cord-291950-9gtsqyfj	499	15	is	be	VBZ
cord-291950-9gtsqyfj	499	16	a	a	DT
cord-291950-9gtsqyfj	499	17	serine	serine	JJ
cord-291950-9gtsqyfj	499	18	-	-	HYPH
cord-291950-9gtsqyfj	499	19	type	type	NN
cord-291950-9gtsqyfj	499	20	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	499	21	with	with	IN
cord-291950-9gtsqyfj	499	22	a	a	DT
cord-291950-9gtsqyfj	499	23	trypsin	trypsin	NN
cord-291950-9gtsqyfj	499	24	-	-	HYPH
cord-291950-9gtsqyfj	499	25	like	like	JJ
cord-291950-9gtsqyfj	499	26	fold	fold	NN
cord-291950-9gtsqyfj	499	27	.	.	.
cord-291950-9gtsqyfj	500	1	Cleavage	cleavage	NN
cord-291950-9gtsqyfj	500	2	of	of	IN
cord-291950-9gtsqyfj	500	3	the	the	DT
cord-291950-9gtsqyfj	500	4	NS2/3	NS2/3	NNP
cord-291950-9gtsqyfj	500	5	site	site	NN
cord-291950-9gtsqyfj	500	6	at	at	IN
cord-291950-9gtsqyfj	500	7	a	a	DT
cord-291950-9gtsqyfj	500	8	LeukAla	LeukAla	NNP
cord-291950-9gtsqyfj	500	9	bond	bond	NN
cord-291950-9gtsqyfj	500	10	is	be	VBZ
cord-291950-9gtsqyfj	500	11	mediated	mediate	VBN
cord-291950-9gtsqyfj	500	12	by	by	IN
cord-291950-9gtsqyfj	500	13	the	the	DT
cord-291950-9gtsqyfj	500	14	second	second	JJ
cord-291950-9gtsqyfj	500	15	virally	virally	RB
cord-291950-9gtsqyfj	500	16	encoded	encode	VBN
cord-291950-9gtsqyfj	500	17	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	500	18	,	,	,
cord-291950-9gtsqyfj	500	19	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	500	20	2	2	CD
cord-291950-9gtsqyfj	500	21	,	,	,
cord-291950-9gtsqyfj	500	22	often	often	RB
cord-291950-9gtsqyfj	500	23	termed	term	VBD
cord-291950-9gtsqyfj	500	24	the	the	DT
cord-291950-9gtsqyfj	500	25	'	'	``
cord-291950-9gtsqyfj	500	26	NS2	NS2	NNP
cord-291950-9gtsqyfj	500	27	-	-	HYPH
cord-291950-9gtsqyfj	500	28	3	3	CD
cord-291950-9gtsqyfj	500	29	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	500	30	'	'	''
cord-291950-9gtsqyfj	500	31	,	,	,
cord-291950-9gtsqyfj	500	32	not	not	RB
cord-291950-9gtsqyfj	500	33	because	because	IN
cord-291950-9gtsqyfj	500	34	of	of	IN
cord-291950-9gtsqyfj	500	35	the	the	DT
cord-291950-9gtsqyfj	500	36	cleavage	cleavage	NN
cord-291950-9gtsqyfj	500	37	site	site	NN
cord-291950-9gtsqyfj	500	38	but	but	CC
cord-291950-9gtsqyfj	500	39	because	because	IN
cord-291950-9gtsqyfj	500	40	the	the	DT
cord-291950-9gtsqyfj	500	41	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	500	42	consists	consist	VBZ
cord-291950-9gtsqyfj	500	43	of	of	IN
cord-291950-9gtsqyfj	500	44	the	the	DT
cord-291950-9gtsqyfj	500	45	NS2	NS2	NNP
cord-291950-9gtsqyfj	500	46	protein	protein	NN
cord-291950-9gtsqyfj	500	47	and	and	CC
cord-291950-9gtsqyfj	500	48	one	one	CD
cord-291950-9gtsqyfj	500	49	-	-	HYPH
cord-291950-9gtsqyfj	500	50	third	third	NN
cord-291950-9gtsqyfj	500	51	of	of	IN
cord-291950-9gtsqyfj	500	52	the	the	DT
cord-291950-9gtsqyfj	500	53	NS3	ns3	RB
cord-291950-9gtsqyfj	500	54	protein	protein	NN
cord-291950-9gtsqyfj	500	55	(	(	-LRB-
cord-291950-9gtsqyfj	500	56	Chapter	chapter	NN
cord-291950-9gtsqyfj	500	57	554	554	CD
cord-291950-9gtsqyfj	500	58	)	)	-RRB-
cord-291950-9gtsqyfj	500	59	.	.	.
cord-291950-9gtsqyfj	501	1	Endopeptidase	Endopeptidase	NNP
cord-291950-9gtsqyfj	501	2	2	2	CD
cord-291950-9gtsqyfj	501	3	is	be	VBZ
cord-291950-9gtsqyfj	501	4	included	include	VBN
cord-291950-9gtsqyfj	501	5	in	in	IN
cord-291950-9gtsqyfj	501	6	family	family	NN
cord-291950-9gtsqyfj	501	7	C18	C18	NNP
cord-291950-9gtsqyfj	501	8	.	.	.
cord-291950-9gtsqyfj	502	1	Site	site	NN
cord-291950-9gtsqyfj	502	2	-	-	HYPH
cord-291950-9gtsqyfj	502	3	directed	direct	VBN
cord-291950-9gtsqyfj	502	4	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	502	5	had	have	VBD
cord-291950-9gtsqyfj	502	6	identified	identify	VBN
cord-291950-9gtsqyfj	502	7	His952	his952	CD
cord-291950-9gtsqyfj	502	8	and	and	CC
cord-291950-9gtsqyfj	502	9	Cys993	cys993	NN
cord-291950-9gtsqyfj	502	10	as	as	IN
cord-291950-9gtsqyfj	502	11	the	the	DT
cord-291950-9gtsqyfj	502	12	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	502	13	dyad	dyad	NN
cord-291950-9gtsqyfj	502	14	[	[	-LRB-
cord-291950-9gtsqyfj	502	15	95	95	CD
cord-291950-9gtsqyfj	502	16	]	]	-RRB-
cord-291950-9gtsqyfj	502	17	.	.	.
cord-291950-9gtsqyfj	503	1	However	however	RB
cord-291950-9gtsqyfj	503	2	,	,	,
cord-291950-9gtsqyfj	503	3	evidence	evidence	NN
cord-291950-9gtsqyfj	503	4	that	that	IN
cord-291950-9gtsqyfj	503	5	the	the	DT
cord-291950-9gtsqyfj	503	6	NS2	NS2	NNP
cord-291950-9gtsqyfj	503	7	-	-	HYPH
cord-291950-9gtsqyfj	503	8	3	3	CD
cord-291950-9gtsqyfj	503	9	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	503	10	is	be	VBZ
cord-291950-9gtsqyfj	503	11	zinc	zinc	NN
cord-291950-9gtsqyfj	503	12	dependent	dependent	JJ
cord-291950-9gtsqyfj	503	13	,	,	,
cord-291950-9gtsqyfj	503	14	including	include	VBG
cord-291950-9gtsqyfj	503	15	inhibition	inhibition	NN
cord-291950-9gtsqyfj	503	16	by	by	IN
cord-291950-9gtsqyfj	503	17	EDTA	EDTA	NNP
cord-291950-9gtsqyfj	503	18	and	and	CC
cord-291950-9gtsqyfj	503	19	increased	increase	VBN
cord-291950-9gtsqyfj	503	20	activity	activity	NN
cord-291950-9gtsqyfj	503	21	with	with	IN
cord-291950-9gtsqyfj	503	22	the	the	DT
cord-291950-9gtsqyfj	503	23	addition	addition	NN
cord-291950-9gtsqyfj	503	24	of	of	IN
cord-291950-9gtsqyfj	503	25	zinc	zinc	NN
cord-291950-9gtsqyfj	503	26	[	[	-LRB-
cord-291950-9gtsqyfj	503	27	96	96	CD
cord-291950-9gtsqyfj	503	28	]	]	-RRB-
cord-291950-9gtsqyfj	503	29	,	,	,
cord-291950-9gtsqyfj	503	30	had	have	VBD
cord-291950-9gtsqyfj	503	31	cast	cast	VBN
cord-291950-9gtsqyfj	503	32	doubt	doubt	NN
cord-291950-9gtsqyfj	503	33	on	on	IN
cord-291950-9gtsqyfj	503	34	the	the	DT
cord-291950-9gtsqyfj	503	35	identification	identification	NN
cord-291950-9gtsqyfj	503	36	of	of	IN
cord-291950-9gtsqyfj	503	37	the	the	DT
cord-291950-9gtsqyfj	503	38	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	503	39	type	type	NN
cord-291950-9gtsqyfj	503	40	.	.	.
cord-291950-9gtsqyfj	504	1	The	the	DT
cord-291950-9gtsqyfj	504	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	504	3	structure	structure	NN
cord-291950-9gtsqyfj	504	4	has	have	VBZ
cord-291950-9gtsqyfj	504	5	been	be	VBN
cord-291950-9gtsqyfj	504	6	determined	determine	VBN
cord-291950-9gtsqyfj	504	7	,	,	,
cord-291950-9gtsqyfj	504	8	and	and	CC
cord-291950-9gtsqyfj	504	9	shows	show	VBZ
cord-291950-9gtsqyfj	504	10	a	a	DT
cord-291950-9gtsqyfj	504	11	fold	fold	NN
cord-291950-9gtsqyfj	504	12	unrelated	unrelated	JJ
cord-291950-9gtsqyfj	504	13	to	to	IN
cord-291950-9gtsqyfj	504	14	that	that	DT
cord-291950-9gtsqyfj	504	15	of	of	IN
cord-291950-9gtsqyfj	504	16	any	any	DT
cord-291950-9gtsqyfj	504	17	other	other	JJ
cord-291950-9gtsqyfj	504	18	peptidase	peptidase	NN
cord-291950-9gtsqyfj	504	19	,	,	,
cord-291950-9gtsqyfj	504	20	hence	hence	RB
cord-291950-9gtsqyfj	504	21	family	family	NN
cord-291950-9gtsqyfj	504	22	C18	C18	NNP
cord-291950-9gtsqyfj	504	23	is	be	VBZ
cord-291950-9gtsqyfj	504	24	the	the	DT
cord-291950-9gtsqyfj	504	25	only	only	JJ
cord-291950-9gtsqyfj	504	26	family	family	NN
cord-291950-9gtsqyfj	504	27	in	in	IN
cord-291950-9gtsqyfj	504	28	clan	clan	NN
cord-291950-9gtsqyfj	504	29	CM	CM	NNP
cord-291950-9gtsqyfj	504	30	(	(	-LRB-
cord-291950-9gtsqyfj	504	31	see	see	VB
cord-291950-9gtsqyfj	504	32	Figure	figure	NN
cord-291950-9gtsqyfj	504	33	404	404	CD
cord-291950-9gtsqyfj	504	34	.34	.34	CD
cord-291950-9gtsqyfj	504	35	)	)	-RRB-
cord-291950-9gtsqyfj	504	36	.	.	.
cord-291950-9gtsqyfj	505	1	The	the	DT
cord-291950-9gtsqyfj	505	2	active	active	JJ
cord-291950-9gtsqyfj	505	3	peptidase	peptidase	NN
cord-291950-9gtsqyfj	505	4	is	be	VBZ
cord-291950-9gtsqyfj	505	5	a	a	DT
cord-291950-9gtsqyfj	505	6	homodimer	homodimer	JJ
cord-291950-9gtsqyfj	505	7	,	,	,
cord-291950-9gtsqyfj	505	8	and	and	CC
cord-291950-9gtsqyfj	505	9	each	each	DT
cord-291950-9gtsqyfj	505	10	monomer	monomer	NN
cord-291950-9gtsqyfj	505	11	comprises	comprise	VBZ
cord-291950-9gtsqyfj	505	12	an	an	DT
cord-291950-9gtsqyfj	505	13	N	n	CD
cord-291950-9gtsqyfj	505	14	-	-	HYPH
cord-291950-9gtsqyfj	505	15	terminal	terminal	NN
cord-291950-9gtsqyfj	505	16	,	,	,
cord-291950-9gtsqyfj	505	17	helical	helical	JJ
cord-291950-9gtsqyfj	505	18	subdomain	subdomain	NN
cord-291950-9gtsqyfj	505	19	,	,	,
cord-291950-9gtsqyfj	505	20	a	a	DT
cord-291950-9gtsqyfj	505	21	C	c	NN
cord-291950-9gtsqyfj	505	22	-	-	HYPH
cord-291950-9gtsqyfj	505	23	terminal	terminal	NN
cord-291950-9gtsqyfj	505	24	subdomain	subdomain	NN
cord-291950-9gtsqyfj	505	25	with	with	IN
cord-291950-9gtsqyfj	505	26	a	a	DT
cord-291950-9gtsqyfj	505	27	β	β	NN
cord-291950-9gtsqyfj	505	28	-	-	HYPH
cord-291950-9gtsqyfj	505	29	sheet	sheet	NN
cord-291950-9gtsqyfj	505	30	and	and	CC
cord-291950-9gtsqyfj	505	31	an	an	DT
cord-291950-9gtsqyfj	505	32	extended	extended	JJ
cord-291950-9gtsqyfj	505	33	linker	linker	NN
cord-291950-9gtsqyfj	505	34	region	region	NN
cord-291950-9gtsqyfj	505	35	.	.	.
cord-291950-9gtsqyfj	506	1	The	the	DT
cord-291950-9gtsqyfj	506	2	active	active	JJ
cord-291950-9gtsqyfj	506	3	site	site	NN
cord-291950-9gtsqyfj	507	1	His	-PRON-	PRP$
cord-291950-9gtsqyfj	507	2	and	and	CC
cord-291950-9gtsqyfj	507	3	Glu	Glu	NNP
cord-291950-9gtsqyfj	507	4	are	be	VBP
cord-291950-9gtsqyfj	507	5	situated	situate	VBN
cord-291950-9gtsqyfj	507	6	in	in	IN
cord-291950-9gtsqyfj	507	7	the	the	DT
cord-291950-9gtsqyfj	507	8	N	n	CD
cord-291950-9gtsqyfj	507	9	-	-	HYPH
cord-291950-9gtsqyfj	507	10	terminal	terminal	NN
cord-291950-9gtsqyfj	507	11	domain	domain	NN
cord-291950-9gtsqyfj	507	12	and	and	CC
cord-291950-9gtsqyfj	507	13	the	the	DT
cord-291950-9gtsqyfj	507	14	Cys	Cys	NNP
cord-291950-9gtsqyfj	507	15	in	in	IN
cord-291950-9gtsqyfj	507	16	the	the	DT
cord-291950-9gtsqyfj	507	17	Cterminal	Cterminal	NNP
cord-291950-9gtsqyfj	507	18	domain	domain	NN
cord-291950-9gtsqyfj	507	19	.	.	.
cord-291950-9gtsqyfj	508	1	An	an	DT
cord-291950-9gtsqyfj	508	2	active	active	JJ
cord-291950-9gtsqyfj	508	3	site	site	NN
cord-291950-9gtsqyfj	508	4	is	be	VBZ
cord-291950-9gtsqyfj	508	5	only	only	RB
cord-291950-9gtsqyfj	508	6	formed	form	VBN
cord-291950-9gtsqyfj	508	7	in	in	IN
cord-291950-9gtsqyfj	508	8	the	the	DT
cord-291950-9gtsqyfj	508	9	dimer	dimer	NN
cord-291950-9gtsqyfj	508	10	,	,	,
cord-291950-9gtsqyfj	508	11	when	when	WRB
cord-291950-9gtsqyfj	508	12	the	the	DT
cord-291950-9gtsqyfj	508	13	His	His	NNP
cord-291950-9gtsqyfj	508	14	and	and	CC
cord-291950-9gtsqyfj	508	15	Glu	Glu	NNP
cord-291950-9gtsqyfj	508	16	from	from	IN
cord-291950-9gtsqyfj	508	17	one	one	CD
cord-291950-9gtsqyfj	508	18	monomer	monomer	NN
cord-291950-9gtsqyfj	508	19	oppose	oppose	VBP
cord-291950-9gtsqyfj	508	20	the	the	DT
cord-291950-9gtsqyfj	508	21	Cys	Cys	NNP
cord-291950-9gtsqyfj	508	22	from	from	IN
cord-291950-9gtsqyfj	508	23	the	the	DT
cord-291950-9gtsqyfj	508	24	other	other	JJ
cord-291950-9gtsqyfj	508	25	,	,	,
cord-291950-9gtsqyfj	508	26	thus	thus	RB
cord-291950-9gtsqyfj	508	27	the	the	DT
cord-291950-9gtsqyfj	508	28	NS2	NS2	NNP
cord-291950-9gtsqyfj	508	29	dimer	dimer	NN
cord-291950-9gtsqyfj	508	30	has	have	VBZ
cord-291950-9gtsqyfj	508	31	two	two	CD
cord-291950-9gtsqyfj	508	32	active	active	JJ
cord-291950-9gtsqyfj	508	33	sites	site	NNS
cord-291950-9gtsqyfj	508	34	[	[	-LRB-
cord-291950-9gtsqyfj	508	35	97	97	CD
cord-291950-9gtsqyfj	508	36	]	]	-RRB-
cord-291950-9gtsqyfj	508	37	.	.	.
cord-291950-9gtsqyfj	509	1	The	the	DT
cord-291950-9gtsqyfj	509	2	formation	formation	NN
cord-291950-9gtsqyfj	509	3	of	of	IN
cord-291950-9gtsqyfj	509	4	an	an	DT
cord-291950-9gtsqyfj	509	5	active	active	JJ
cord-291950-9gtsqyfj	509	6	site	site	NN
cord-291950-9gtsqyfj	509	7	between	between	IN
cord-291950-9gtsqyfj	509	8	different	different	JJ
cord-291950-9gtsqyfj	509	9	subunits	subunit	NNS
cord-291950-9gtsqyfj	509	10	in	in	IN
cord-291950-9gtsqyfj	509	11	a	a	DT
cord-291950-9gtsqyfj	509	12	dimer	dimer	NN
cord-291950-9gtsqyfj	509	13	is	be	VBZ
cord-291950-9gtsqyfj	509	14	unusual	unusual	JJ
cord-291950-9gtsqyfj	509	15	amongst	amongst	IN
cord-291950-9gtsqyfj	509	16	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	509	17	,	,	,
cord-291950-9gtsqyfj	509	18	but	but	CC
cord-291950-9gtsqyfj	509	19	does	do	VBZ
cord-291950-9gtsqyfj	509	20	happen	happen	VB
cord-291950-9gtsqyfj	509	21	with	with	IN
cord-291950-9gtsqyfj	509	22	retropepsins	retropepsin	NNS
cord-291950-9gtsqyfj	509	23	(	(	-LRB-
cord-291950-9gtsqyfj	509	24	see	see	VB
cord-291950-9gtsqyfj	509	25	Chapter	chapter	NN
cord-291950-9gtsqyfj	509	26	44	44	CD
cord-291950-9gtsqyfj	509	27	)	)	-RRB-
cord-291950-9gtsqyfj	509	28	and	and	CC
cord-291950-9gtsqyfj	509	29	has	have	VBZ
cord-291950-9gtsqyfj	509	30	been	be	VBN
cord-291950-9gtsqyfj	509	31	proposed	propose	VBN
cord-291950-9gtsqyfj	509	32	for	for	IN
cord-291950-9gtsqyfj	509	33	the	the	DT
cord-291950-9gtsqyfj	509	34	Pyrococcus	Pyrococcus	NNP
cord-291950-9gtsqyfj	509	35	furiosus	furiosus	NN
cord-291950-9gtsqyfj	509	36	protease	protease	NN
cord-291950-9gtsqyfj	509	37	1	1	CD
cord-291950-9gtsqyfj	509	38	(	(	-LRB-
cord-291950-9gtsqyfj	509	39	see	see	VB
cord-291950-9gtsqyfj	509	40	Chapter	chapter	NN
cord-291950-9gtsqyfj	509	41	549	549	CD
cord-291950-9gtsqyfj	509	42	)	)	-RRB-
cord-291950-9gtsqyfj	509	43	.	.	.
cord-291950-9gtsqyfj	510	1	The	the	DT
cord-291950-9gtsqyfj	510	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	510	3	structure	structure	NN
cord-291950-9gtsqyfj	510	4	of	of	IN
cord-291950-9gtsqyfj	510	5	the	the	DT
cord-291950-9gtsqyfj	510	6	NS2	NS2	NNP
cord-291950-9gtsqyfj	510	7	dimer	dimer	NN
cord-291950-9gtsqyfj	510	8	also	also	RB
cord-291950-9gtsqyfj	510	9	revealed	reveal	VBD
cord-291950-9gtsqyfj	510	10	the	the	DT
cord-291950-9gtsqyfj	510	11	presence	presence	NN
cord-291950-9gtsqyfj	510	12	of	of	IN
cord-291950-9gtsqyfj	510	13	a	a	DT
cord-291950-9gtsqyfj	510	14	structural	structural	JJ
cord-291950-9gtsqyfj	510	15	zinc	zinc	NN
cord-291950-9gtsqyfj	510	16	ion	ion	NN
cord-291950-9gtsqyfj	510	17	,	,	,
cord-291950-9gtsqyfj	510	18	which	which	WDT
cord-291950-9gtsqyfj	510	19	explains	explain	VBZ
cord-291950-9gtsqyfj	510	20	the	the	DT
cord-291950-9gtsqyfj	510	21	metal	metal	NN
cord-291950-9gtsqyfj	510	22	-	-	HYPH
cord-291950-9gtsqyfj	510	23	dependence	dependence	NN
cord-291950-9gtsqyfj	510	24	.	.	.
cord-291950-9gtsqyfj	511	1	Family	Family	NNP
cord-291950-9gtsqyfj	511	2	C9	C9	NNP
cord-291950-9gtsqyfj	511	3	includes	include	VBZ
cord-291950-9gtsqyfj	511	4	the	the	DT
cord-291950-9gtsqyfj	511	5	non	non	JJ
cord-291950-9gtsqyfj	511	6	-	-	JJ
cord-291950-9gtsqyfj	511	7	structural	structural	JJ
cord-291950-9gtsqyfj	511	8	polyproteinprocessing	polyproteinprocesse	VBG
cord-291950-9gtsqyfj	511	9	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	511	10	from	from	IN
cord-291950-9gtsqyfj	511	11	togaviruses	togaviruses	NNP
cord-291950-9gtsqyfj	511	12	,	,	,
cord-291950-9gtsqyfj	511	13	the	the	DT
cord-291950-9gtsqyfj	511	14	nsP2	nsP2	NNP
cord-291950-9gtsqyfj	511	15	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	511	16	.	.	.
cord-291950-9gtsqyfj	512	1	The	the	DT
cord-291950-9gtsqyfj	512	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	512	3	dyad	dyad	NN
cord-291950-9gtsqyfj	512	4	has	have	VBZ
cord-291950-9gtsqyfj	512	5	been	be	VBN
cord-291950-9gtsqyfj	512	6	identified	identify	VBN
cord-291950-9gtsqyfj	512	7	by	by	IN
cord-291950-9gtsqyfj	512	8	site	site	NN
cord-291950-9gtsqyfj	512	9	-	-	HYPH
cord-291950-9gtsqyfj	512	10	specific	specific	JJ
cord-291950-9gtsqyfj	512	11	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	512	12	[	[	-LRB-
cord-291950-9gtsqyfj	512	13	98	98	CD
cord-291950-9gtsqyfj	512	14	]	]	-RRB-
cord-291950-9gtsqyfj	512	15	,	,	,
cord-291950-9gtsqyfj	512	16	and	and	CC
cord-291950-9gtsqyfj	512	17	the	the	DT
cord-291950-9gtsqyfj	512	18	nsP2	nsp2	JJ
cord-291950-9gtsqyfj	512	19	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	512	20	is	be	VBZ
cord-291950-9gtsqyfj	512	21	a	a	DT
cord-291950-9gtsqyfj	512	22	bifunctional	bifunctional	JJ
cord-291950-9gtsqyfj	512	23	molecule	molecule	NN
cord-291950-9gtsqyfj	512	24	with	with	IN
cord-291950-9gtsqyfj	512	25	the	the	DT
cord-291950-9gtsqyfj	512	26	peptidase	peptidase	NN
cord-291950-9gtsqyfj	512	27	unit	unit	NN
cord-291950-9gtsqyfj	512	28	at	at	IN
cord-291950-9gtsqyfj	512	29	the	the	DT
cord-291950-9gtsqyfj	512	30	C	C	NNP
cord-291950-9gtsqyfj	512	31	-	-	HYPH
cord-291950-9gtsqyfj	512	32	terminus	terminus	NN
cord-291950-9gtsqyfj	512	33	and	and	CC
cord-291950-9gtsqyfj	512	34	an	an	DT
cord-291950-9gtsqyfj	512	35	N	n	CD
cord-291950-9gtsqyfj	512	36	-	-	HYPH
cord-291950-9gtsqyfj	512	37	terminal	terminal	JJ
cord-291950-9gtsqyfj	512	38	unit	unit	NN
cord-291950-9gtsqyfj	512	39	that	that	WDT
cord-291950-9gtsqyfj	512	40	is	be	VBZ
cord-291950-9gtsqyfj	512	41	probably	probably	RB
cord-291950-9gtsqyfj	512	42	involved	involve	VBN
cord-291950-9gtsqyfj	512	43	in	in	IN
cord-291950-9gtsqyfj	512	44	RNA	RNA	NNP
cord-291950-9gtsqyfj	512	45	-	-	HYPH
cord-291950-9gtsqyfj	512	46	binding	bind	VBG
cord-291950-9gtsqyfj	512	47	during	during	IN
cord-291950-9gtsqyfj	512	48	replication	replication	NN
cord-291950-9gtsqyfj	512	49	.	.	.
cord-291950-9gtsqyfj	513	1	The	the	DT
cord-291950-9gtsqyfj	513	2	N	n	CD
cord-291950-9gtsqyfj	513	3	-	-	HYPH
cord-291950-9gtsqyfj	513	4	terminal	terminal	NN
cord-291950-9gtsqyfj	513	5	domain	domain	NN
cord-291950-9gtsqyfj	513	6	is	be	VBZ
cord-291950-9gtsqyfj	513	7	homologous	homologous	JJ
cord-291950-9gtsqyfj	513	8	to	to	IN
cord-291950-9gtsqyfj	513	9	a	a	DT
cord-291950-9gtsqyfj	513	10	similarly	similarly	RB
cord-291950-9gtsqyfj	513	11	located	locate	VBN
cord-291950-9gtsqyfj	513	12	domain	domain	NN
cord-291950-9gtsqyfj	513	13	in	in	IN
cord-291950-9gtsqyfj	513	14	the	the	DT
cord-291950-9gtsqyfj	513	15	cucumber	cucumber	NN
cord-291950-9gtsqyfj	513	16	green	green	JJ
cord-291950-9gtsqyfj	513	17	mottle	mottle	NN
cord-291950-9gtsqyfj	513	18	mosaic	mosaic	NNP
cord-291950-9gtsqyfj	513	19	tobamovirus	tobamovirus	NNP
cord-291950-9gtsqyfj	513	20	.	.	.
cord-291950-9gtsqyfj	514	1	The	the	DT
cord-291950-9gtsqyfj	514	2	crystal	crystal	JJ
cord-291950-9gtsqyfj	514	3	structure	structure	NN
cord-291950-9gtsqyfj	514	4	of	of	IN
cord-291950-9gtsqyfj	514	5	the	the	DT
cord-291950-9gtsqyfj	514	6	nsP2	nsp2	JJ
cord-291950-9gtsqyfj	514	7	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	514	8	from	from	IN
cord-291950-9gtsqyfj	514	9	Venezuelan	venezuelan	JJ
cord-291950-9gtsqyfj	514	10	equine	equine	NN
cord-291950-9gtsqyfj	514	11	encephalitis	encephalitis	NN
cord-291950-9gtsqyfj	514	12	virus	virus	NN
cord-291950-9gtsqyfj	514	13	has	have	VBZ
cord-291950-9gtsqyfj	514	14	been	be	VBN
cord-291950-9gtsqyfj	514	15	solved	solve	VBN
cord-291950-9gtsqyfj	514	16	,	,	,
cord-291950-9gtsqyfj	514	17	and	and	CC
cord-291950-9gtsqyfj	514	18	shows	show	VBZ
cord-291950-9gtsqyfj	514	19	a	a	DT
cord-291950-9gtsqyfj	514	20	fold	fold	NN
cord-291950-9gtsqyfj	514	21	unrelated	unrelated	JJ
cord-291950-9gtsqyfj	514	22	to	to	IN
cord-291950-9gtsqyfj	514	23	that	that	DT
cord-291950-9gtsqyfj	514	24	of	of	IN
cord-291950-9gtsqyfj	514	25	any	any	DT
cord-291950-9gtsqyfj	514	26	other	other	JJ
cord-291950-9gtsqyfj	514	27	peptidase	peptidase	NN
cord-291950-9gtsqyfj	514	28	[	[	-LRB-
cord-291950-9gtsqyfj	514	29	99	99	CD
cord-291950-9gtsqyfj	514	30	]	]	-RRB-
cord-291950-9gtsqyfj	514	31	(	(	-LRB-
cord-291950-9gtsqyfj	514	32	see	see	VB
cord-291950-9gtsqyfj	514	33	Figure	figure	NN
cord-291950-9gtsqyfj	514	34	404	404	CD
cord-291950-9gtsqyfj	514	35	.35	.35	CD
cord-291950-9gtsqyfj	514	36	)	)	-RRB-
cord-291950-9gtsqyfj	514	37	.	.	.
cord-291950-9gtsqyfj	515	1	Hence	hence	RB
cord-291950-9gtsqyfj	515	2	C9	C9	NNP
cord-291950-9gtsqyfj	515	3	is	be	VBZ
cord-291950-9gtsqyfj	515	4	the	the	DT
cord-291950-9gtsqyfj	515	5	only	only	JJ
cord-291950-9gtsqyfj	515	6	family	family	NN
cord-291950-9gtsqyfj	515	7	in	in	IN
cord-291950-9gtsqyfj	515	8	clan	clan	NN
cord-291950-9gtsqyfj	515	9	CN	CN	NNP
cord-291950-9gtsqyfj	515	10	.	.	.
cord-291950-9gtsqyfj	516	1	Until	until	IN
cord-291950-9gtsqyfj	516	2	the	the	DT
cord-291950-9gtsqyfj	516	3	structure	structure	NN
cord-291950-9gtsqyfj	516	4	was	be	VBD
cord-291950-9gtsqyfj	516	5	solved	solve	VBN
cord-291950-9gtsqyfj	516	6	,	,	,
cord-291950-9gtsqyfj	516	7	it	-PRON-	PRP
cord-291950-9gtsqyfj	516	8	had	have	VBD
cord-291950-9gtsqyfj	516	9	been	be	VBN
cord-291950-9gtsqyfj	516	10	expected	expect	VBN
cord-291950-9gtsqyfj	516	11	that	that	IN
cord-291950-9gtsqyfj	516	12	members	member	NNS
cord-291950-9gtsqyfj	516	13	of	of	IN
cord-291950-9gtsqyfj	516	14	family	family	NN
cord-291950-9gtsqyfj	516	15	C9	C9	NNP
cord-291950-9gtsqyfj	516	16	would	would	MD
cord-291950-9gtsqyfj	516	17	have	have	VB
cord-291950-9gtsqyfj	516	18	a	a	DT
cord-291950-9gtsqyfj	516	19	fold	fold	NN
cord-291950-9gtsqyfj	516	20	similar	similar	JJ
cord-291950-9gtsqyfj	516	21	to	to	IN
cord-291950-9gtsqyfj	516	22	that	that	DT
cord-291950-9gtsqyfj	516	23	of	of	IN
cord-291950-9gtsqyfj	516	24	papain	papain	NN
cord-291950-9gtsqyfj	516	25	.	.	.
cord-291950-9gtsqyfj	517	1	Clan	Clan	NNP
cord-291950-9gtsqyfj	517	2	PC	PC	NNP
cord-291950-9gtsqyfj	517	3	is	be	VBZ
cord-291950-9gtsqyfj	517	4	another	another	DT
cord-291950-9gtsqyfj	517	5	clan	clan	NN
cord-291950-9gtsqyfj	517	6	containing	contain	VBG
cord-291950-9gtsqyfj	517	7	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	517	8	of	of	IN
cord-291950-9gtsqyfj	517	9	different	different	JJ
cord-291950-9gtsqyfj	517	10	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	517	11	types	type	NNS
cord-291950-9gtsqyfj	517	12	,	,	,
cord-291950-9gtsqyfj	517	13	and	and	CC
cord-291950-9gtsqyfj	517	14	subclan	subclan	NNP
cord-291950-9gtsqyfj	517	15	PC(C	PC(C	NNS
cord-291950-9gtsqyfj	517	16	)	)	-RRB-
cord-291950-9gtsqyfj	517	17	contains	contain	VBZ
cord-291950-9gtsqyfj	517	18	the	the	DT
cord-291950-9gtsqyfj	517	19	cysteinetype	cysteinetype	NN
cord-291950-9gtsqyfj	517	20	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	517	21	in	in	IN
cord-291950-9gtsqyfj	517	22	the	the	DT
cord-291950-9gtsqyfj	517	23	clan	clan	NN
cord-291950-9gtsqyfj	517	24	.	.	.
cord-291950-9gtsqyfj	518	1	Members	member	NNS
cord-291950-9gtsqyfj	518	2	of	of	IN
cord-291950-9gtsqyfj	518	3	the	the	DT
cord-291950-9gtsqyfj	518	4	clan	clan	NN
cord-291950-9gtsqyfj	518	5	have	have	VBP
cord-291950-9gtsqyfj	518	6	a	a	DT
cord-291950-9gtsqyfj	518	7	The	the	DT
cord-291950-9gtsqyfj	518	8	image	image	NN
cord-291950-9gtsqyfj	518	9	was	be	VBD
cord-291950-9gtsqyfj	518	10	prepared	prepare	VBN
cord-291950-9gtsqyfj	518	11	from	from	IN
cord-291950-9gtsqyfj	518	12	the	the	DT
cord-291950-9gtsqyfj	518	13	Protein	Protein	NNP
cord-291950-9gtsqyfj	518	14	Data	Data	NNP
cord-291950-9gtsqyfj	518	15	Bank	Bank	NNP
cord-291950-9gtsqyfj	518	16	entry	entry	NN
cord-291950-9gtsqyfj	518	17	(	(	-LRB-
cord-291950-9gtsqyfj	518	18	2HD0	2hd0	CD
cord-291950-9gtsqyfj	518	19	)	)	-RRB-
cord-291950-9gtsqyfj	518	20	as	as	IN
cord-291950-9gtsqyfj	518	21	described	describe	VBN
cord-291950-9gtsqyfj	518	22	in	in	IN
cord-291950-9gtsqyfj	518	23	the	the	DT
cord-291950-9gtsqyfj	518	24	Introduction	introduction	NN
cord-291950-9gtsqyfj	518	25	(	(	-LRB-
cord-291950-9gtsqyfj	518	26	p.	p.	NN
cord-291950-9gtsqyfj	518	27	li	li	NNP
cord-291950-9gtsqyfj	518	28	)	)	-RRB-
cord-291950-9gtsqyfj	518	29	.	.	.
cord-291950-9gtsqyfj	519	1	One	one	CD
cord-291950-9gtsqyfj	519	2	homodimer	homodimer	NN
cord-291950-9gtsqyfj	519	3	is	be	VBZ
cord-291950-9gtsqyfj	519	4	shown	show	VBN
cord-291950-9gtsqyfj	519	5	.	.	.
cord-291950-9gtsqyfj	520	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	520	2	residues	residue	NNS
cord-291950-9gtsqyfj	520	3	are	be	VBP
cord-291950-9gtsqyfj	520	4	shown	show	VBN
cord-291950-9gtsqyfj	520	5	in	in	IN
cord-291950-9gtsqyfj	520	6	ball	ball	NN
cord-291950-9gtsqyfj	520	7	-	-	HYPH
cord-291950-9gtsqyfj	520	8	and	and	CC
cord-291950-9gtsqyfj	520	9	-	-	HYPH
cord-291950-9gtsqyfj	520	10	stick	stick	NN
cord-291950-9gtsqyfj	520	11	representation	representation	NN
cord-291950-9gtsqyfj	520	12	for	for	IN
cord-291950-9gtsqyfj	520	13	each	each	DT
cord-291950-9gtsqyfj	520	14	monomer	monomer	NN
cord-291950-9gtsqyfj	520	15	:	:	:
cord-291950-9gtsqyfj	521	1	His952	his952	UH
cord-291950-9gtsqyfj	521	2	in	in	IN
cord-291950-9gtsqyfj	521	3	purple	purple	NN
cord-291950-9gtsqyfj	521	4	,	,	,
cord-291950-9gtsqyfj	521	5	Glu972	Glu972	NNS
cord-291950-9gtsqyfj	521	6	in	in	IN
cord-291950-9gtsqyfj	521	7	blue	blue	NN
cord-291950-9gtsqyfj	521	8	and	and	CC
cord-291950-9gtsqyfj	521	9	Cys993	cys993	NN
cord-291950-9gtsqyfj	521	10	in	in	IN
cord-291950-9gtsqyfj	521	11	yellow	yellow	JJ
cord-291950-9gtsqyfj	521	12	(	(	-LRB-
cord-291950-9gtsqyfj	521	13	numbering	number	VBG
cord-291950-9gtsqyfj	521	14	as	as	IN
cord-291950-9gtsqyfj	521	15	in	in	IN
cord-291950-9gtsqyfj	521	16	PDB	PDB	NNP
cord-291950-9gtsqyfj	521	17	entry	entry	NN
cord-291950-9gtsqyfj	521	18	)	)	-RRB-
cord-291950-9gtsqyfj	521	19	.	.	.
cord-291950-9gtsqyfj	522	1	fold	fold	VB
cord-291950-9gtsqyfj	522	2	similar	similar	JJ
cord-291950-9gtsqyfj	522	3	to	to	IN
cord-291950-9gtsqyfj	522	4	that	that	DT
cord-291950-9gtsqyfj	522	5	of	of	IN
cord-291950-9gtsqyfj	522	6	class	class	NN
cord-291950-9gtsqyfj	522	7	I	-PRON-	PRP
cord-291950-9gtsqyfj	522	8	glutamine	glutamine	VBP
cord-291950-9gtsqyfj	522	9	amidotransferase	amidotransferase	NN
cord-291950-9gtsqyfj	522	10	,	,	,
cord-291950-9gtsqyfj	522	11	which	which	WDT
cord-291950-9gtsqyfj	522	12	consists	consist	VBZ
cord-291950-9gtsqyfj	522	13	of	of	IN
cord-291950-9gtsqyfj	522	14	an	an	DT
cord-291950-9gtsqyfj	522	15	α	α	NN
cord-291950-9gtsqyfj	522	16	/	/	SYM
cord-291950-9gtsqyfj	522	17	β	β	NN
cord-291950-9gtsqyfj	522	18	/	/	SYM
cord-291950-9gtsqyfj	522	19	α	α	NNP
cord-291950-9gtsqyfj	522	20	sandwich	sandwich	NN
cord-291950-9gtsqyfj	522	21	.	.	.
cord-291950-9gtsqyfj	523	1	The	the	DT
cord-291950-9gtsqyfj	523	2	nucleophile	nucleophile	NN
cord-291950-9gtsqyfj	523	3	can	can	MD
cord-291950-9gtsqyfj	523	4	be	be	VB
cord-291950-9gtsqyfj	523	5	either	either	CC
cord-291950-9gtsqyfj	523	6	a	a	DT
cord-291950-9gtsqyfj	523	7	cysteine	cysteine	NN
cord-291950-9gtsqyfj	523	8	or	or	CC
cord-291950-9gtsqyfj	523	9	a	a	DT
cord-291950-9gtsqyfj	523	10	serine	serine	NN
cord-291950-9gtsqyfj	523	11	,	,	,
cord-291950-9gtsqyfj	523	12	and	and	CC
cord-291950-9gtsqyfj	523	13	these	these	DT
cord-291950-9gtsqyfj	523	14	are	be	VBP
cord-291950-9gtsqyfj	523	15	in	in	IN
cord-291950-9gtsqyfj	523	16	equivalent	equivalent	JJ
cord-291950-9gtsqyfj	523	17	positions	position	NNS
cord-291950-9gtsqyfj	523	18	.	.	.
cord-291950-9gtsqyfj	524	1	Family	Family	NNP
cord-291950-9gtsqyfj	524	2	C26	C26	NNP
cord-291950-9gtsqyfj	524	3	,	,	,
cord-291950-9gtsqyfj	524	4	contains	contain	VBZ
cord-291950-9gtsqyfj	524	5	γ	γ	NN
cord-291950-9gtsqyfj	524	6	-	-	HYPH
cord-291950-9gtsqyfj	524	7	glutamyl	glutamyl	NNP
cord-291950-9gtsqyfj	524	8	hydrolase	hydrolase	NNP
cord-291950-9gtsqyfj	524	9	(	(	-LRB-
cord-291950-9gtsqyfj	524	10	Chapter	chapter	NN
cord-291950-9gtsqyfj	524	11	550	550	CD
cord-291950-9gtsqyfj	524	12	)	)	-RRB-
cord-291950-9gtsqyfj	524	13	.	.	.
cord-291950-9gtsqyfj	525	1	The	the	DT
cord-291950-9gtsqyfj	525	2	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	525	3	structure	structure	NN
cord-291950-9gtsqyfj	525	4	of	of	IN
cord-291950-9gtsqyfj	525	5	human	human	JJ
cord-291950-9gtsqyfj	525	6	γ	γ	NN
cord-291950-9gtsqyfj	525	7	-	-	HYPH
cord-291950-9gtsqyfj	525	8	glutamyl	glutamyl	NNP
cord-291950-9gtsqyfj	525	9	hydrolase	hydrolase	NN
cord-291950-9gtsqyfj	525	10	(	(	-LRB-
cord-291950-9gtsqyfj	525	11	Figure	figure	NN
cord-291950-9gtsqyfj	525	12	404	404	CD
cord-291950-9gtsqyfj	525	13	.36	.36	NFP
cord-291950-9gtsqyfj	525	14	)	)	-RRB-
cord-291950-9gtsqyfj	525	15	shows	show	VBZ
cord-291950-9gtsqyfj	525	16	a	a	DT
cord-291950-9gtsqyfj	525	17	homotetramer	homotetramer	NN
cord-291950-9gtsqyfj	525	18	.	.	.
cord-291950-9gtsqyfj	526	1	A	a	DT
cord-291950-9gtsqyfj	526	2	Cys	Cys	NNP
cord-291950-9gtsqyfj	526	3	,	,	,
cord-291950-9gtsqyfj	526	4	His	-PRON-	PRP$
cord-291950-9gtsqyfj	526	5	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	526	6	dyad	dyad	NN
cord-291950-9gtsqyfj	526	7	is	be	VBZ
cord-291950-9gtsqyfj	526	8	evident	evident	JJ
cord-291950-9gtsqyfj	526	9	,	,	,
cord-291950-9gtsqyfj	526	10	and	and	CC
cord-291950-9gtsqyfj	526	11	the	the	DT
cord-291950-9gtsqyfj	526	12	histidine	histidine	NN
cord-291950-9gtsqyfj	526	13	is	be	VBZ
cord-291950-9gtsqyfj	526	14	hydrogenbonded	hydrogenbonde	VBN
cord-291950-9gtsqyfj	526	15	to	to	IN
cord-291950-9gtsqyfj	526	16	a	a	DT
cord-291950-9gtsqyfj	526	17	glutamate	glutamate	NN
cord-291950-9gtsqyfj	526	18	and	and	CC
cord-291950-9gtsqyfj	526	19	a	a	DT
cord-291950-9gtsqyfj	526	20	tyrosine	tyrosine	NN
cord-291950-9gtsqyfj	526	21	,	,	,
cord-291950-9gtsqyfj	526	22	either	either	DT
cord-291950-9gtsqyfj	526	23	of	of	IN
cord-291950-9gtsqyfj	526	24	which	which	WDT
cord-291950-9gtsqyfj	526	25	could	could	MD
cord-291950-9gtsqyfj	526	26	be	be	VB
cord-291950-9gtsqyfj	526	27	a	a	DT
cord-291950-9gtsqyfj	526	28	third	third	JJ
cord-291950-9gtsqyfj	526	29	member	member	NN
cord-291950-9gtsqyfj	526	30	of	of	IN
cord-291950-9gtsqyfj	526	31	a	a	DT
cord-291950-9gtsqyfj	526	32	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	526	33	triad	triad	NN
cord-291950-9gtsqyfj	526	34	[	[	-LRB-
cord-291950-9gtsqyfj	526	35	100	100	CD
cord-291950-9gtsqyfj	526	36	]	]	-RRB-
cord-291950-9gtsqyfj	526	37	.	.	.
cord-291950-9gtsqyfj	527	1	Family	Family	NNP
cord-291950-9gtsqyfj	527	2	C56	C56	NNP
cord-291950-9gtsqyfj	527	3	contains	contain	VBZ
cord-291950-9gtsqyfj	527	4	only	only	RB
cord-291950-9gtsqyfj	527	5	protease	protease	NN
cord-291950-9gtsqyfj	527	6	I	-PRON-	PRP
cord-291950-9gtsqyfj	527	7	from	from	IN
cord-291950-9gtsqyfj	527	8	Pyrococcus	Pyrococcus	NNP
cord-291950-9gtsqyfj	527	9	(	(	-LRB-
cord-291950-9gtsqyfj	527	10	see	see	VB
cord-291950-9gtsqyfj	527	11	Chapter	chapter	NN
cord-291950-9gtsqyfj	527	12	549	549	CD
cord-291950-9gtsqyfj	527	13	)	)	-RRB-
cord-291950-9gtsqyfj	527	14	.	.	.
cord-291950-9gtsqyfj	528	1	Although	although	IN
cord-291950-9gtsqyfj	528	2	the	the	DT
cord-291950-9gtsqyfj	528	3	crystal	crystal	NN
cord-291950-9gtsqyfj	528	4	structure	structure	NN
cord-291950-9gtsqyfj	528	5	has	have	VBZ
cord-291950-9gtsqyfj	528	6	been	be	VBN
cord-291950-9gtsqyfj	528	7	solved	solve	VBN
cord-291950-9gtsqyfj	528	8	(	(	-LRB-
cord-291950-9gtsqyfj	528	9	Figure	figure	NN
cord-291950-9gtsqyfj	528	10	404.37	404.37	CD
cord-291950-9gtsqyfj	528	11	)	)	-RRB-
cord-291950-9gtsqyfj	528	12	,	,	,
cord-291950-9gtsqyfj	528	13	the	the	DT
cord-291950-9gtsqyfj	528	14	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	528	15	mechanism	mechanism	NN
cord-291950-9gtsqyfj	528	16	is	be	VBZ
cord-291950-9gtsqyfj	528	17	not	not	RB
cord-291950-9gtsqyfj	528	18	known	know	VBN
cord-291950-9gtsqyfj	528	19	with	with	IN
cord-291950-9gtsqyfj	528	20	certainty	certainty	NN
cord-291950-9gtsqyfj	528	21	.	.	.
cord-291950-9gtsqyfj	529	1	The	the	DT
cord-291950-9gtsqyfj	529	2	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	529	3	is	be	VBZ
cord-291950-9gtsqyfj	529	4	a	a	DT
cord-291950-9gtsqyfj	529	5	homotrimer	homotrimer	NN
cord-291950-9gtsqyfj	529	6	,	,	,
cord-291950-9gtsqyfj	529	7	and	and	CC
cord-291950-9gtsqyfj	529	8	Cys100	cys100	NN
cord-291950-9gtsqyfj	529	9	and	and	CC
cord-291950-9gtsqyfj	529	10	His101	His101	,
cord-291950-9gtsqyfj	529	11	have	have	VBP
cord-291950-9gtsqyfj	529	12	been	be	VBN
cord-291950-9gtsqyfj	529	13	implicated	implicate	VBN
cord-291950-9gtsqyfj	529	14	in	in	IN
cord-291950-9gtsqyfj	529	15	the	the	DT
cord-291950-9gtsqyfj	529	16	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	529	17	mechanism	mechanism	NN
cord-291950-9gtsqyfj	529	18	,	,	,
cord-291950-9gtsqyfj	529	19	with	with	IN
cord-291950-9gtsqyfj	529	20	the	the	DT
cord-291950-9gtsqyfj	529	21	suggestion	suggestion	NN
cord-291950-9gtsqyfj	529	22	that	that	IN
cord-291950-9gtsqyfj	529	23	a	a	DT
cord-291950-9gtsqyfj	529	24	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	529	25	triad	triad	NN
cord-291950-9gtsqyfj	529	26	is	be	VBZ
cord-291950-9gtsqyfj	529	27	formed	form	VBN
cord-291950-9gtsqyfj	529	28	between	between	IN
cord-291950-9gtsqyfj	529	29	residues	residue	NNS
cord-291950-9gtsqyfj	529	30	from	from	IN
cord-291950-9gtsqyfj	529	31	opposing	oppose	VBG
cord-291950-9gtsqyfj	529	32	monomers	monomer	NNS
cord-291950-9gtsqyfj	529	33	,	,	,
cord-291950-9gtsqyfj	529	34	with	with	IN
cord-291950-9gtsqyfj	529	35	Glu74	Glu74	NNP
cord-291950-9gtsqyfj	529	36	completing	complete	VBG
cord-291950-9gtsqyfj	529	37	the	the	DT
cord-291950-9gtsqyfj	529	38	active	active	JJ
cord-291950-9gtsqyfj	529	39	site	site	NN
cord-291950-9gtsqyfj	529	40	.	.	.
cord-291950-9gtsqyfj	530	1	This	this	DT
cord-291950-9gtsqyfj	530	2	would	would	MD
cord-291950-9gtsqyfj	530	3	be	be	VB
cord-291950-9gtsqyfj	530	4	a	a	DT
cord-291950-9gtsqyfj	530	5	unique	unique	JJ
cord-291950-9gtsqyfj	530	6	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	530	7	mechanism	mechanism	NN
cord-291950-9gtsqyfj	530	8	amongst	amongst	IN
cord-291950-9gtsqyfj	530	9	the	the	DT
cord-291950-9gtsqyfj	530	10	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	530	11	.	.	.
cord-291950-9gtsqyfj	531	1	His101	His101	NNP
cord-291950-9gtsqyfj	531	2	is	be	VBZ
cord-291950-9gtsqyfj	531	3	poorly	poorly	RB
cord-291950-9gtsqyfj	531	4	conserved	conserve	VBN
cord-291950-9gtsqyfj	531	5	,	,	,
cord-291950-9gtsqyfj	531	6	however	however	RB
cord-291950-9gtsqyfj	531	7	,	,	,
cord-291950-9gtsqyfj	531	8	which	which	WDT
cord-291950-9gtsqyfj	531	9	may	may	MD
cord-291950-9gtsqyfj	531	10	mean	mean	VB
cord-291950-9gtsqyfj	531	11	that	that	IN
cord-291950-9gtsqyfj	531	12	very	very	RB
cord-291950-9gtsqyfj	531	13	few	few	JJ
cord-291950-9gtsqyfj	531	14	members	member	NNS
cord-291950-9gtsqyfj	531	15	of	of	IN
cord-291950-9gtsqyfj	531	16	the	the	DT
cord-291950-9gtsqyfj	531	17	protein	protein	NN
cord-291950-9gtsqyfj	531	18	family	family	NN
cord-291950-9gtsqyfj	531	19	are	be	VBP
cord-291950-9gtsqyfj	531	20	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	531	21	.	.	.
cord-291950-9gtsqyfj	532	1	His101	His101	NFP
cord-291950-9gtsqyfj	532	2	is	be	VBZ
cord-291950-9gtsqyfj	532	3	also	also	RB
cord-291950-9gtsqyfj	532	4	not	not	RB
cord-291950-9gtsqyfj	532	5	in	in	IN
cord-291950-9gtsqyfj	532	6	an	an	DT
cord-291950-9gtsqyfj	532	7	equivalent	equivalent	JJ
cord-291950-9gtsqyfj	532	8	position	position	NN
cord-291950-9gtsqyfj	532	9	to	to	IN
cord-291950-9gtsqyfj	532	10	His220	his220	RB
cord-291950-9gtsqyfj	532	11	from	from	IN
cord-291950-9gtsqyfj	532	12	γ	γ	NN
cord-291950-9gtsqyfj	532	13	-	-	HYPH
cord-291950-9gtsqyfj	532	14	glutamyl	glutamyl	NNP
cord-291950-9gtsqyfj	532	15	hydrolase	hydrolase	NNP
cord-291950-9gtsqyfj	532	16	.	.	.
cord-291950-9gtsqyfj	533	1	The	the	DT
cord-291950-9gtsqyfj	533	2	image	image	NN
cord-291950-9gtsqyfj	533	3	was	be	VBD
cord-291950-9gtsqyfj	533	4	prepared	prepare	VBN
cord-291950-9gtsqyfj	533	5	from	from	IN
cord-291950-9gtsqyfj	533	6	the	the	DT
cord-291950-9gtsqyfj	533	7	Protein	Protein	NNP
cord-291950-9gtsqyfj	533	8	Data	Data	NNP
cord-291950-9gtsqyfj	533	9	Bank	Bank	NNP
cord-291950-9gtsqyfj	533	10	entry	entry	NN
cord-291950-9gtsqyfj	533	11	(	(	-LRB-
cord-291950-9gtsqyfj	533	12	1L9X	1l9x	CD
cord-291950-9gtsqyfj	533	13	)	)	-RRB-
cord-291950-9gtsqyfj	533	14	as	as	IN
cord-291950-9gtsqyfj	533	15	described	describe	VBN
cord-291950-9gtsqyfj	533	16	in	in	IN
cord-291950-9gtsqyfj	533	17	the	the	DT
cord-291950-9gtsqyfj	533	18	Introduction	introduction	NN
cord-291950-9gtsqyfj	533	19	(	(	-LRB-
cord-291950-9gtsqyfj	533	20	p.	p.	NN
cord-291950-9gtsqyfj	533	21	li	li	NNP
cord-291950-9gtsqyfj	533	22	)	)	-RRB-
cord-291950-9gtsqyfj	533	23	.	.	.
cord-291950-9gtsqyfj	534	1	One	one	CD
cord-291950-9gtsqyfj	534	2	monomer	monomer	NN
cord-291950-9gtsqyfj	534	3	of	of	IN
cord-291950-9gtsqyfj	534	4	the	the	DT
cord-291950-9gtsqyfj	534	5	tetramer	tetramer	NN
cord-291950-9gtsqyfj	534	6	is	be	VBZ
cord-291950-9gtsqyfj	534	7	shown	show	VBN
cord-291950-9gtsqyfj	534	8	.	.	.
cord-291950-9gtsqyfj	535	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	535	2	residues	residue	NNS
cord-291950-9gtsqyfj	535	3	are	be	VBP
cord-291950-9gtsqyfj	535	4	shown	show	VBN
cord-291950-9gtsqyfj	535	5	in	in	IN
cord-291950-9gtsqyfj	535	6	ball	ball	NN
cord-291950-9gtsqyfj	535	7	-	-	HYPH
cord-291950-9gtsqyfj	535	8	and	and	CC
cord-291950-9gtsqyfj	535	9	-	-	HYPH
cord-291950-9gtsqyfj	535	10	stick	stick	NN
cord-291950-9gtsqyfj	535	11	representation	representation	NN
cord-291950-9gtsqyfj	535	12	:	:	:
cord-291950-9gtsqyfj	535	13	Cys110	cys110	ADD
cord-291950-9gtsqyfj	536	1	and	and	CC
cord-291950-9gtsqyfj	536	2	His220	his220	RB
cord-291950-9gtsqyfj	537	1	(	(	-LRB-
cord-291950-9gtsqyfj	537	2	numbering	number	VBG
cord-291950-9gtsqyfj	537	3	as	as	IN
cord-291950-9gtsqyfj	537	4	in	in	IN
cord-291950-9gtsqyfj	537	5	PDB	PDB	NNP
cord-291950-9gtsqyfj	537	6	entry	entry	NN
cord-291950-9gtsqyfj	537	7	)	)	-RRB-
cord-291950-9gtsqyfj	537	8	.	.	.
cord-291950-9gtsqyfj	538	1	FIGURE	figure	NN
cord-291950-9gtsqyfj	538	2	404.37	404.37	CD
cord-291950-9gtsqyfj	539	1	Richardson	Richardson	NNP
cord-291950-9gtsqyfj	539	2	diagram	diagram	NN
cord-291950-9gtsqyfj	539	3	of	of	IN
cord-291950-9gtsqyfj	539	4	Pyrococcus	Pyrococcus	NNP
cord-291950-9gtsqyfj	539	5	horikoshii	horikoshii	NNP
cord-291950-9gtsqyfj	539	6	PfpI	PfpI	NNP
cord-291950-9gtsqyfj	539	7	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	539	8	.	.	.
cord-291950-9gtsqyfj	540	1	The	the	DT
cord-291950-9gtsqyfj	540	2	image	image	NN
cord-291950-9gtsqyfj	540	3	was	be	VBD
cord-291950-9gtsqyfj	540	4	prepared	prepare	VBN
cord-291950-9gtsqyfj	540	5	from	from	IN
cord-291950-9gtsqyfj	540	6	the	the	DT
cord-291950-9gtsqyfj	540	7	Protein	Protein	NNP
cord-291950-9gtsqyfj	540	8	Data	Data	NNP
cord-291950-9gtsqyfj	540	9	Bank	Bank	NNP
cord-291950-9gtsqyfj	540	10	entry	entry	NN
cord-291950-9gtsqyfj	540	11	(	(	-LRB-
cord-291950-9gtsqyfj	540	12	1G2I	1g2i	CD
cord-291950-9gtsqyfj	540	13	)	)	-RRB-
cord-291950-9gtsqyfj	540	14	as	as	IN
cord-291950-9gtsqyfj	540	15	described	describe	VBN
cord-291950-9gtsqyfj	540	16	in	in	IN
cord-291950-9gtsqyfj	540	17	the	the	DT
cord-291950-9gtsqyfj	540	18	Introduction	introduction	NN
cord-291950-9gtsqyfj	540	19	(	(	-LRB-
cord-291950-9gtsqyfj	540	20	p.	p.	NN
cord-291950-9gtsqyfj	540	21	li	li	NNP
cord-291950-9gtsqyfj	540	22	)	)	-RRB-
cord-291950-9gtsqyfj	540	23	.	.	.
cord-291950-9gtsqyfj	541	1	One	one	CD
cord-291950-9gtsqyfj	541	2	monomer	monomer	NN
cord-291950-9gtsqyfj	541	3	of	of	IN
cord-291950-9gtsqyfj	541	4	the	the	DT
cord-291950-9gtsqyfj	541	5	homotrimer	homotrimer	NN
cord-291950-9gtsqyfj	541	6	is	be	VBZ
cord-291950-9gtsqyfj	541	7	shown	show	VBN
cord-291950-9gtsqyfj	541	8	.	.	.
cord-291950-9gtsqyfj	542	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	542	2	residues	residue	NNS
cord-291950-9gtsqyfj	542	3	are	be	VBP
cord-291950-9gtsqyfj	542	4	shown	show	VBN
cord-291950-9gtsqyfj	542	5	in	in	IN
cord-291950-9gtsqyfj	542	6	ball	ball	NN
cord-291950-9gtsqyfj	542	7	-	-	HYPH
cord-291950-9gtsqyfj	542	8	and	and	CC
cord-291950-9gtsqyfj	542	9	-	-	HYPH
cord-291950-9gtsqyfj	542	10	stick	stick	NN
cord-291950-9gtsqyfj	542	11	representation	representation	NN
cord-291950-9gtsqyfj	542	12	:	:	:
cord-291950-9gtsqyfj	543	1	Cys100	Cys100	NFP
cord-291950-9gtsqyfj	544	1	and	and	CC
cord-291950-9gtsqyfj	544	2	His101	His101	.
cord-291950-9gtsqyfj	545	1	(	(	-LRB-
cord-291950-9gtsqyfj	545	2	numbering	number	VBG
cord-291950-9gtsqyfj	545	3	as	as	IN
cord-291950-9gtsqyfj	545	4	in	in	IN
cord-291950-9gtsqyfj	545	5	PDB	PDB	NNP
cord-291950-9gtsqyfj	545	6	entry	entry	NN
cord-291950-9gtsqyfj	545	7	)	)	-RRB-
cord-291950-9gtsqyfj	545	8	.	.	.
cord-291950-9gtsqyfj	546	1	Family	Family	NNP
cord-291950-9gtsqyfj	546	2	C40	C40	NNP
cord-291950-9gtsqyfj	546	3	contains	contain	VBZ
cord-291950-9gtsqyfj	546	4	dipeptidyl	dipeptidyl	JJ
cord-291950-9gtsqyfj	546	5	-	-	HYPH
cord-291950-9gtsqyfj	546	6	peptidase	peptidase	NN
cord-291950-9gtsqyfj	546	7	VI	vi	NN
cord-291950-9gtsqyfj	546	8	from	from	IN
cord-291950-9gtsqyfj	546	9	Bacillus	Bacillus	NNP
cord-291950-9gtsqyfj	546	10	sphaericus	sphaericus	NNP
cord-291950-9gtsqyfj	546	11	.	.	.
cord-291950-9gtsqyfj	547	1	This	this	DT
cord-291950-9gtsqyfj	547	2	is	be	VBZ
cord-291950-9gtsqyfj	547	3	an	an	DT
cord-291950-9gtsqyfj	547	4	enzyme	enzyme	NN
cord-291950-9gtsqyfj	547	5	that	that	WDT
cord-291950-9gtsqyfj	547	6	is	be	VBZ
cord-291950-9gtsqyfj	547	7	expressed	express	VBN
cord-291950-9gtsqyfj	547	8	during	during	IN
cord-291950-9gtsqyfj	547	9	sporulation	sporulation	NN
cord-291950-9gtsqyfj	547	10	,	,	,
cord-291950-9gtsqyfj	547	11	and	and	CC
cord-291950-9gtsqyfj	547	12	is	be	VBZ
cord-291950-9gtsqyfj	547	13	responsible	responsible	JJ
cord-291950-9gtsqyfj	547	14	for	for	IN
cord-291950-9gtsqyfj	547	15	degradation	degradation	NN
cord-291950-9gtsqyfj	547	16	of	of	IN
cord-291950-9gtsqyfj	547	17	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	547	18	cell	cell	NN
cord-291950-9gtsqyfj	547	19	wall	wall	NN
cord-291950-9gtsqyfj	547	20	components	component	NNS
cord-291950-9gtsqyfj	547	21	.	.	.
cord-291950-9gtsqyfj	548	1	Because	because	IN
cord-291950-9gtsqyfj	548	2	the	the	DT
cord-291950-9gtsqyfj	548	3	enzyme	enzyme	NN
cord-291950-9gtsqyfj	548	4	is	be	VBZ
cord-291950-9gtsqyfj	548	5	cytoplasmic	cytoplasmic	JJ
cord-291950-9gtsqyfj	548	6	and	and	CC
cord-291950-9gtsqyfj	548	7	is	be	VBZ
cord-291950-9gtsqyfj	548	8	synthesized	synthesize	VBN
cord-291950-9gtsqyfj	548	9	without	without	IN
cord-291950-9gtsqyfj	548	10	signal	signal	NN
cord-291950-9gtsqyfj	548	11	and	and	CC
cord-291950-9gtsqyfj	548	12	propeptides	propeptide	NNS
cord-291950-9gtsqyfj	548	13	,	,	,
cord-291950-9gtsqyfj	548	14	it	-PRON-	PRP
cord-291950-9gtsqyfj	548	15	is	be	VBZ
cord-291950-9gtsqyfj	548	16	presumably	presumably	RB
cord-291950-9gtsqyfj	548	17	acting	act	VBG
cord-291950-9gtsqyfj	548	18	at	at	IN
cord-291950-9gtsqyfj	548	19	a	a	DT
cord-291950-9gtsqyfj	548	20	late	late	JJ
cord-291950-9gtsqyfj	548	21	stage	stage	NN
cord-291950-9gtsqyfj	548	22	in	in	IN
cord-291950-9gtsqyfj	548	23	cell	cell	NN
cord-291950-9gtsqyfj	548	24	wall	wall	NN
cord-291950-9gtsqyfj	548	25	component	component	NN
cord-291950-9gtsqyfj	548	26	turnover	turnover	NN
cord-291950-9gtsqyfj	548	27	.	.	.
cord-291950-9gtsqyfj	549	1	There	there	EX
cord-291950-9gtsqyfj	549	2	are	be	VBP
cord-291950-9gtsqyfj	549	3	a	a	DT
cord-291950-9gtsqyfj	549	4	number	number	NN
cord-291950-9gtsqyfj	549	5	of	of	IN
cord-291950-9gtsqyfj	549	6	homologs	homolog	NNS
cord-291950-9gtsqyfj	549	7	of	of	IN
cord-291950-9gtsqyfj	549	8	the	the	DT
cord-291950-9gtsqyfj	549	9	Bacillus	Bacillus	NNP
cord-291950-9gtsqyfj	549	10	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	549	11	,	,	,
cord-291950-9gtsqyfj	549	12	but	but	CC
cord-291950-9gtsqyfj	549	13	similarity	similarity	NN
cord-291950-9gtsqyfj	549	14	is	be	VBZ
cord-291950-9gtsqyfj	549	15	restricted	restrict	VBN
cord-291950-9gtsqyfj	549	16	to	to	IN
cord-291950-9gtsqyfj	549	17	a	a	DT
cord-291950-9gtsqyfj	549	18	C	c	NN
cord-291950-9gtsqyfj	549	19	-	-	HYPH
cord-291950-9gtsqyfj	549	20	terminal	terminal	NN
cord-291950-9gtsqyfj	549	21	domain	domain	NN
cord-291950-9gtsqyfj	549	22	of	of	IN
cord-291950-9gtsqyfj	549	23	110	110	CD
cord-291950-9gtsqyfj	549	24	residues	residue	NNS
cord-291950-9gtsqyfj	549	25	.	.	.
cord-291950-9gtsqyfj	550	1	These	these	DT
cord-291950-9gtsqyfj	550	2	include	include	VBP
cord-291950-9gtsqyfj	550	3	nlpC	nlpC	NNP
cord-291950-9gtsqyfj	550	4	lipoprotein	lipoprotein	NN
cord-291950-9gtsqyfj	550	5	from	from	IN
cord-291950-9gtsqyfj	550	6	Escherichia	Escherichia	NNP
cord-291950-9gtsqyfj	550	7	coli	coli	NNS
cord-291950-9gtsqyfj	550	8	,	,	,
cord-291950-9gtsqyfj	550	9	invasion	invasion	NN
cord-291950-9gtsqyfj	550	10	-	-	HYPH
cord-291950-9gtsqyfj	550	11	associated	associate	VBN
cord-291950-9gtsqyfj	550	12	protein	protein	NN
cord-291950-9gtsqyfj	550	13	p60	p60	NN
cord-291950-9gtsqyfj	550	14	from	from	IN
cord-291950-9gtsqyfj	550	15	Listeria	Listeria	NNP
cord-291950-9gtsqyfj	550	16	species	specie	NNS
cord-291950-9gtsqyfj	550	17	,	,	,
cord-291950-9gtsqyfj	550	18	a	a	DT
cord-291950-9gtsqyfj	550	19	starch	starch	NN
cord-291950-9gtsqyfj	550	20	-	-	HYPH
cord-291950-9gtsqyfj	550	21	degrading	degrade	VBG
cord-291950-9gtsqyfj	550	22	enzyme	enzyme	NN
cord-291950-9gtsqyfj	550	23	from	from	IN
cord-291950-9gtsqyfj	550	24	Clostridium	Clostridium	NNP
cord-291950-9gtsqyfj	550	25	acetobutylicum	acetobutylicum	NNP
cord-291950-9gtsqyfj	550	26	,	,	,
cord-291950-9gtsqyfj	550	27	and	and	CC
cord-291950-9gtsqyfj	550	28	a	a	DT
cord-291950-9gtsqyfj	550	29	phosphatase	phosphatase	NN
cord-291950-9gtsqyfj	550	30	-	-	HYPH
cord-291950-9gtsqyfj	550	31	associated	associate	VBN
cord-291950-9gtsqyfj	550	32	protein	protein	NN
cord-291950-9gtsqyfj	550	33	from	from	IN
cord-291950-9gtsqyfj	550	34	Bacillus	bacillus	NN
cord-291950-9gtsqyfj	550	35	subtilis	subtili	NNS
cord-291950-9gtsqyfj	550	36	.	.	.
cord-291950-9gtsqyfj	551	1	There	there	EX
cord-291950-9gtsqyfj	551	2	are	be	VBP
cord-291950-9gtsqyfj	551	3	single	single	JJ
cord-291950-9gtsqyfj	551	4	conserved	conserve	VBN
cord-291950-9gtsqyfj	551	5	Cys	Cys	NNP
cord-291950-9gtsqyfj	551	6	and	and	CC
cord-291950-9gtsqyfj	551	7	His	-PRON-	PRP$
cord-291950-9gtsqyfj	551	8	residues	residue	NNS
cord-291950-9gtsqyfj	551	9	)	)	-RRB-
cord-291950-9gtsqyfj	551	10	.	.	.
cord-291950-9gtsqyfj	552	1	The	the	DT
cord-291950-9gtsqyfj	552	2	crystal	crystal	NN
cord-291950-9gtsqyfj	552	3	structures	structure	NNS
cord-291950-9gtsqyfj	552	4	of	of	IN
cord-291950-9gtsqyfj	552	5	several	several	JJ
cord-291950-9gtsqyfj	552	6	members	member	NNS
cord-291950-9gtsqyfj	552	7	of	of	IN
cord-291950-9gtsqyfj	552	8	the	the	DT
cord-291950-9gtsqyfj	552	9	family	family	NN
cord-291950-9gtsqyfj	552	10	have	have	VBP
cord-291950-9gtsqyfj	552	11	been	be	VBN
cord-291950-9gtsqyfj	552	12	solved	solve	VBN
cord-291950-9gtsqyfj	552	13	,	,	,
cord-291950-9gtsqyfj	552	14	and	and	CC
cord-291950-9gtsqyfj	552	15	the	the	DT
cord-291950-9gtsqyfj	552	16	fold	fold	NN
cord-291950-9gtsqyfj	552	17	has	have	VBZ
cord-291950-9gtsqyfj	552	18	been	be	VBN
cord-291950-9gtsqyfj	552	19	described	describe	VBN
cord-291950-9gtsqyfj	552	20	as	as	IN
cord-291950-9gtsqyfj	552	21	'	'	``
cord-291950-9gtsqyfj	552	22	papain	papain	NN
cord-291950-9gtsqyfj	552	23	-	-	HYPH
cord-291950-9gtsqyfj	552	24	like	like	JJ
cord-291950-9gtsqyfj	552	25	'	'	''
cord-291950-9gtsqyfj	552	26	but	but	CC
cord-291950-9gtsqyfj	552	27	primitive	primitive	JJ
cord-291950-9gtsqyfj	552	28	[	[	-LRB-
cord-291950-9gtsqyfj	552	29	101	101	CD
cord-291950-9gtsqyfj	552	30	]	]	-RRB-
cord-291950-9gtsqyfj	552	31	.	.	.
cord-291950-9gtsqyfj	553	1	However	however	RB
cord-291950-9gtsqyfj	553	2	,	,	,
cord-291950-9gtsqyfj	553	3	unlike	unlike	IN
cord-291950-9gtsqyfj	553	4	papain	papain	NN
cord-291950-9gtsqyfj	553	5	where	where	WRB
cord-291950-9gtsqyfj	553	6	the	the	DT
cord-291950-9gtsqyfj	553	7	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	553	8	Cys	Cys	NNP
cord-291950-9gtsqyfj	553	9	is	be	VBZ
cord-291950-9gtsqyfj	553	10	at	at	IN
cord-291950-9gtsqyfj	553	11	the	the	DT
cord-291950-9gtsqyfj	553	12	N	n	CD
cord-291950-9gtsqyfj	553	13	-	-	HYPH
cord-291950-9gtsqyfj	553	14	terminus	terminus	NN
cord-291950-9gtsqyfj	553	15	of	of	IN
cord-291950-9gtsqyfj	553	16	a	a	DT
cord-291950-9gtsqyfj	553	17	helix	helix	NN
cord-291950-9gtsqyfj	553	18	,	,	,
cord-291950-9gtsqyfj	553	19	in	in	IN
cord-291950-9gtsqyfj	553	20	the	the	DT
cord-291950-9gtsqyfj	553	21	structures	structure	NNS
cord-291950-9gtsqyfj	553	22	from	from	IN
cord-291950-9gtsqyfj	553	23	family	family	NN
cord-291950-9gtsqyfj	553	24	C40	C40	NNP
cord-291950-9gtsqyfj	554	1	the	the	DT
cord-291950-9gtsqyfj	554	2	active	active	JJ
cord-291950-9gtsqyfj	554	3	site	site	NN
cord-291950-9gtsqyfj	554	4	Cys	Cys	NNP
cord-291950-9gtsqyfj	554	5	is	be	VBZ
cord-291950-9gtsqyfj	554	6	at	at	IN
cord-291950-9gtsqyfj	554	7	the	the	DT
cord-291950-9gtsqyfj	554	8	C	c	NN
cord-291950-9gtsqyfj	554	9	-	-	HYPH
cord-291950-9gtsqyfj	554	10	terminus	terminus	NN
cord-291950-9gtsqyfj	554	11	of	of	IN
cord-291950-9gtsqyfj	554	12	a	a	DT
cord-291950-9gtsqyfj	554	13	helix	helix	NN
cord-291950-9gtsqyfj	554	14	,	,	,
cord-291950-9gtsqyfj	554	15	which	which	WDT
cord-291950-9gtsqyfj	554	16	means	mean	VBZ
cord-291950-9gtsqyfj	554	17	the	the	DT
cord-291950-9gtsqyfj	554	18	sequence	sequence	NN
cord-291950-9gtsqyfj	554	19	must	must	MD
cord-291950-9gtsqyfj	554	20	run	run	VB
cord-291950-9gtsqyfj	554	21	in	in	IN
cord-291950-9gtsqyfj	554	22	the	the	DT
cord-291950-9gtsqyfj	554	23	opposite	opposite	JJ
cord-291950-9gtsqyfj	554	24	direction	direction	NN
cord-291950-9gtsqyfj	554	25	to	to	IN
cord-291950-9gtsqyfj	554	26	that	that	DT
cord-291950-9gtsqyfj	554	27	in	in	IN
cord-291950-9gtsqyfj	554	28	papain	papain	NN
cord-291950-9gtsqyfj	554	29	(	(	-LRB-
cord-291950-9gtsqyfj	554	30	see	see	VB
cord-291950-9gtsqyfj	554	31	Figure	Figure	NNP
cord-291950-9gtsqyfj	554	32	404	404	CD
cord-291950-9gtsqyfj	554	33	.	.	.
cord-291950-9gtsqyfj	554	34	38	38	CD
cord-291950-9gtsqyfj	554	35	)	)	-RRB-
cord-291950-9gtsqyfj	554	36	.	.	.
cord-291950-9gtsqyfj	555	1	No	no	DT
cord-291950-9gtsqyfj	555	2	similarity	similarity	NN
cord-291950-9gtsqyfj	555	3	between	between	IN
cord-291950-9gtsqyfj	555	4	the	the	DT
cord-291950-9gtsqyfj	555	5	structures	structure	NNS
cord-291950-9gtsqyfj	555	6	can	can	MD
cord-291950-9gtsqyfj	555	7	be	be	VB
cord-291950-9gtsqyfj	555	8	detected	detect	VBN
cord-291950-9gtsqyfj	555	9	using	use	VBG
cord-291950-9gtsqyfj	555	10	the	the	DT
cord-291950-9gtsqyfj	555	11	DALI	DALI	NNP
cord-291950-9gtsqyfj	555	12	algorithm	algorithm	NN
cord-291950-9gtsqyfj	555	13	[	[	-LRB-
cord-291950-9gtsqyfj	555	14	102	102	CD
cord-291950-9gtsqyfj	555	15	]	]	-RRB-
cord-291950-9gtsqyfj	555	16	.	.	.
cord-291950-9gtsqyfj	556	1	The	the	DT
cord-291950-9gtsqyfj	556	2	structural	structural	JJ
cord-291950-9gtsqyfj	556	3	resemblances	resemblance	NNS
cord-291950-9gtsqyfj	556	4	are	be	VBP
cord-291950-9gtsqyfj	556	5	therefore	therefore	RB
cord-291950-9gtsqyfj	556	6	assumed	assume	VBN
cord-291950-9gtsqyfj	556	7	to	to	TO
cord-291950-9gtsqyfj	556	8	be	be	VB
cord-291950-9gtsqyfj	556	9	derived	derive	VBN
cord-291950-9gtsqyfj	556	10	from	from	IN
cord-291950-9gtsqyfj	556	11	convergent	convergent	JJ
cord-291950-9gtsqyfj	556	12	rather	rather	RB
cord-291950-9gtsqyfj	556	13	than	than	IN
cord-291950-9gtsqyfj	556	14	divergent	divergent	JJ
cord-291950-9gtsqyfj	556	15	evolution	evolution	NN
cord-291950-9gtsqyfj	556	16	,	,	,
cord-291950-9gtsqyfj	556	17	and	and	CC
cord-291950-9gtsqyfj	556	18	proteins	protein	NNS
cord-291950-9gtsqyfj	556	19	in	in	IN
cord-291950-9gtsqyfj	556	20	C40	C40	NNP
cord-291950-9gtsqyfj	556	21	are	be	VBP
cord-291950-9gtsqyfj	556	22	assigned	assign	VBN
cord-291950-9gtsqyfj	556	23	to	to	IN
cord-291950-9gtsqyfj	556	24	the	the	DT
cord-291950-9gtsqyfj	556	25	clan	clan	NN
cord-291950-9gtsqyfj	556	26	CO	CO	NNP
cord-291950-9gtsqyfj	556	27	.	.	.
cord-291950-9gtsqyfj	557	1	All	all	DT
cord-291950-9gtsqyfj	557	2	members	member	NNS
cord-291950-9gtsqyfj	557	3	of	of	IN
cord-291950-9gtsqyfj	557	4	this	this	DT
cord-291950-9gtsqyfj	557	5	family	family	NN
cord-291950-9gtsqyfj	557	6	have	have	VBP
cord-291950-9gtsqyfj	557	7	either	either	CC
cord-291950-9gtsqyfj	557	8	a	a	DT
cord-291950-9gtsqyfj	557	9	signal	signal	NN
cord-291950-9gtsqyfj	557	10	peptide	peptide	NN
cord-291950-9gtsqyfj	557	11	or	or	CC
cord-291950-9gtsqyfj	557	12	a	a	DT
cord-291950-9gtsqyfj	557	13	transmembrane	transmembrane	NN
cord-291950-9gtsqyfj	557	14	region	region	NN
cord-291950-9gtsqyfj	557	15	,	,	,
cord-291950-9gtsqyfj	557	16	indicating	indicate	VBG
cord-291950-9gtsqyfj	557	17	a	a	DT
cord-291950-9gtsqyfj	557	18	cell	cell	NN
cord-291950-9gtsqyfj	557	19	-	-	HYPH
cord-291950-9gtsqyfj	557	20	surface	surface	NN
cord-291950-9gtsqyfj	557	21	location	location	NN
cord-291950-9gtsqyfj	557	22	.	.	.
cord-291950-9gtsqyfj	558	1	Clan	Clan	NNP
cord-291950-9gtsqyfj	558	2	PB	PB	NNP
cord-291950-9gtsqyfj	558	3	contains	contain	VBZ
cord-291950-9gtsqyfj	558	4	N	n	CD
cord-291950-9gtsqyfj	558	5	-	-	HYPH
cord-291950-9gtsqyfj	558	6	terminal	terminal	NN
cord-291950-9gtsqyfj	558	7	nucleophile	nucleophile	NN
cord-291950-9gtsqyfj	558	8	hydrolases	hydrolase	NNS
cord-291950-9gtsqyfj	558	9	,	,	,
cord-291950-9gtsqyfj	558	10	amongst	amongst	IN
cord-291950-9gtsqyfj	558	11	which	which	WDT
cord-291950-9gtsqyfj	558	12	the	the	DT
cord-291950-9gtsqyfj	558	13	most	most	RBS
cord-291950-9gtsqyfj	558	14	important	important	JJ
cord-291950-9gtsqyfj	558	15	peptidase	peptidase	NN
cord-291950-9gtsqyfj	558	16	is	be	VBZ
cord-291950-9gtsqyfj	558	17	the	the	DT
cord-291950-9gtsqyfj	558	18	proteasome	proteasome	NN
cord-291950-9gtsqyfj	558	19	.	.	.
cord-291950-9gtsqyfj	559	1	In	in	IN
cord-291950-9gtsqyfj	559	2	the	the	DT
cord-291950-9gtsqyfj	559	3	proteasome	proteasome	NN
cord-291950-9gtsqyfj	559	4	the	the	DT
cord-291950-9gtsqyfj	559	5	N	n	CD
cord-291950-9gtsqyfj	559	6	-	-	HYPH
cord-291950-9gtsqyfj	559	7	terminal	terminal	NN
cord-291950-9gtsqyfj	559	8	nucleophile	nucleophile	NN
cord-291950-9gtsqyfj	559	9	is	be	VBZ
cord-291950-9gtsqyfj	559	10	threonine	threonine	NN
cord-291950-9gtsqyfj	559	11	,	,	,
cord-291950-9gtsqyfj	559	12	but	but	CC
cord-291950-9gtsqyfj	559	13	there	there	EX
cord-291950-9gtsqyfj	559	14	are	be	VBP
cord-291950-9gtsqyfj	559	15	members	member	NNS
cord-291950-9gtsqyfj	559	16	of	of	IN
cord-291950-9gtsqyfj	559	17	the	the	DT
cord-291950-9gtsqyfj	559	18	clan	clan	NN
cord-291950-9gtsqyfj	559	19	in	in	IN
cord-291950-9gtsqyfj	559	20	which	which	WDT
cord-291950-9gtsqyfj	559	21	the	the	DT
cord-291950-9gtsqyfj	559	22	nucleophile	nucleophile	NN
cord-291950-9gtsqyfj	559	23	is	be	VBZ
cord-291950-9gtsqyfj	559	24	cysteine	cysteine	NN
cord-291950-9gtsqyfj	559	25	.	.	.
cord-291950-9gtsqyfj	560	1	These	these	DT
cord-291950-9gtsqyfj	560	2	are	be	VBP
cord-291950-9gtsqyfj	560	3	exclusively	exclusively	RB
cord-291950-9gtsqyfj	560	4	self	self	NN
cord-291950-9gtsqyfj	560	5	-	-	HYPH
cord-291950-9gtsqyfj	560	6	processing	processing	NN
cord-291950-9gtsqyfj	560	7	proenzymes	proenzyme	NNS
cord-291950-9gtsqyfj	560	8	that	that	WDT
cord-291950-9gtsqyfj	560	9	carry	carry	VBP
cord-291950-9gtsqyfj	560	10	out	out	RP
cord-291950-9gtsqyfj	560	11	a	a	DT
cord-291950-9gtsqyfj	560	12	single	single	JJ
cord-291950-9gtsqyfj	560	13	peptide	peptide	NN
cord-291950-9gtsqyfj	560	14	bond	bond	NN
cord-291950-9gtsqyfj	560	15	cleavage	cleavage	NN
cord-291950-9gtsqyfj	560	16	to	to	TO
cord-291950-9gtsqyfj	560	17	form	form	VB
cord-291950-9gtsqyfj	560	18	the	the	DT
cord-291950-9gtsqyfj	560	19	active	active	JJ
cord-291950-9gtsqyfj	560	20	enzyme	enzyme	NN
cord-291950-9gtsqyfj	560	21	,	,	,
cord-291950-9gtsqyfj	560	22	but	but	CC
cord-291950-9gtsqyfj	560	23	in	in	IN
cord-291950-9gtsqyfj	560	24	contrast	contrast	NN
cord-291950-9gtsqyfj	560	25	to	to	IN
cord-291950-9gtsqyfj	560	26	the	the	DT
cord-291950-9gtsqyfj	560	27	proteasome	proteasome	NN
cord-291950-9gtsqyfj	560	28	,	,	,
cord-291950-9gtsqyfj	560	29	the	the	DT
cord-291950-9gtsqyfj	560	30	enzyme	enzyme	NN
cord-291950-9gtsqyfj	560	31	that	that	WDT
cord-291950-9gtsqyfj	560	32	is	be	VBZ
cord-291950-9gtsqyfj	560	33	formed	form	VBN
cord-291950-9gtsqyfj	560	34	is	be	VBZ
cord-291950-9gtsqyfj	560	35	not	not	RB
cord-291950-9gtsqyfj	560	36	a	a	DT
cord-291950-9gtsqyfj	560	37	peptidase	peptidase	NN
cord-291950-9gtsqyfj	560	38	.	.	.
cord-291950-9gtsqyfj	561	1	The	the	DT
cord-291950-9gtsqyfj	561	2	cysteinetype	cysteinetype	NN
cord-291950-9gtsqyfj	561	3	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	561	4	of	of	IN
cord-291950-9gtsqyfj	561	5	clan	clan	NN
cord-291950-9gtsqyfj	561	6	PB	PB	NNP
cord-291950-9gtsqyfj	561	7	form	form	VBP
cord-291950-9gtsqyfj	561	8	a	a	DT
cord-291950-9gtsqyfj	561	9	subclan	subclan	NN
cord-291950-9gtsqyfj	561	10	PB(C	pb(c	NN
cord-291950-9gtsqyfj	561	11	)	)	-RRB-
cord-291950-9gtsqyfj	561	12	,	,	,
cord-291950-9gtsqyfj	561	13	and	and	CC
cord-291950-9gtsqyfj	561	14	are	be	VBP
cord-291950-9gtsqyfj	561	15	discussed	discuss	VBN
cord-291950-9gtsqyfj	561	16	more	more	RBR
cord-291950-9gtsqyfj	561	17	fully	fully	RB
cord-291950-9gtsqyfj	561	18	in	in	IN
cord-291950-9gtsqyfj	561	19	Chapter	chapter	NN
cord-291950-9gtsqyfj	561	20	808	808	CD
cord-291950-9gtsqyfj	561	21	.	.	.
cord-291950-9gtsqyfj	562	1	There	there	EX
cord-291950-9gtsqyfj	562	2	are	be	VBP
cord-291950-9gtsqyfj	562	3	a	a	DT
cord-291950-9gtsqyfj	562	4	few	few	JJ
cord-291950-9gtsqyfj	562	5	other	other	JJ
cord-291950-9gtsqyfj	562	6	families	family	NNS
cord-291950-9gtsqyfj	562	7	of	of	IN
cord-291950-9gtsqyfj	562	8	cysteine	cysteine	NN
cord-291950-9gtsqyfj	562	9	peptidases	peptidase	NNS
cord-291950-9gtsqyfj	562	10	for	for	IN
cord-291950-9gtsqyfj	562	11	which	which	WDT
cord-291950-9gtsqyfj	562	12	no	no	DT
cord-291950-9gtsqyfj	562	13	tertiary	tertiary	JJ
cord-291950-9gtsqyfj	562	14	structures	structure	NNS
cord-291950-9gtsqyfj	562	15	are	be	VBP
cord-291950-9gtsqyfj	562	16	available	available	JJ
cord-291950-9gtsqyfj	562	17	and	and	CC
cord-291950-9gtsqyfj	562	18	too	too	RB
cord-291950-9gtsqyfj	562	19	little	little	JJ
cord-291950-9gtsqyfj	562	20	is	be	VBZ
cord-291950-9gtsqyfj	562	21	known	know	VBN
cord-291950-9gtsqyfj	562	22	about	about	IN
cord-291950-9gtsqyfj	562	23	the	the	DT
cord-291950-9gtsqyfj	562	24	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	562	25	machinery	machinery	NN
cord-291950-9gtsqyfj	562	26	to	to	TO
cord-291950-9gtsqyfj	562	27	permit	permit	VB
cord-291950-9gtsqyfj	562	28	any	any	DT
cord-291950-9gtsqyfj	562	29	conclusions	conclusion	NNS
cord-291950-9gtsqyfj	562	30	about	about	IN
cord-291950-9gtsqyfj	562	31	their	-PRON-	PRP$
cord-291950-9gtsqyfj	562	32	relationships	relationship	NNS
cord-291950-9gtsqyfj	562	33	.	.	.
cord-291950-9gtsqyfj	563	1	Family	Family	NNP
cord-291950-9gtsqyfj	563	2	C6	C6	NNP
cord-291950-9gtsqyfj	563	3	contains	contain	VBZ
cord-291950-9gtsqyfj	563	4	one	one	CD
cord-291950-9gtsqyfj	563	5	of	of	IN
cord-291950-9gtsqyfj	563	6	the	the	DT
cord-291950-9gtsqyfj	563	7	two	two	CD
cord-291950-9gtsqyfj	563	8	cysteine	cysteine	NN
cord-291950-9gtsqyfj	563	9	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	563	10	found	find	VBN
cord-291950-9gtsqyfj	563	11	in	in	IN
cord-291950-9gtsqyfj	563	12	potyviruses	potyviruses	NNP
cord-291950-9gtsqyfj	563	13	,	,	,
cord-291950-9gtsqyfj	563	14	the	the	DT
cord-291950-9gtsqyfj	563	15	helper	helper	NN
cord-291950-9gtsqyfj	563	16	-	-	HYPH
cord-291950-9gtsqyfj	563	17	component	component	NN
cord-291950-9gtsqyfj	563	18	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	563	19	.	.	.
cord-291950-9gtsqyfj	564	1	(	(	-LRB-
cord-291950-9gtsqyfj	564	2	The	the	DT
cord-291950-9gtsqyfj	564	3	second	second	JJ
cord-291950-9gtsqyfj	564	4	is	be	VBZ
cord-291950-9gtsqyfj	564	5	the	the	DT
cord-291950-9gtsqyfj	564	6	NIa	nia	JJ
cord-291950-9gtsqyfj	564	7	peptidase	peptidase	NN
cord-291950-9gtsqyfj	564	8	,	,	,
cord-291950-9gtsqyfj	564	9	Chapter	chapter	NN
cord-291950-9gtsqyfj	564	10	544	544	CD
cord-291950-9gtsqyfj	564	11	)	)	-RRB-
cord-291950-9gtsqyfj	565	1	The	the	DT
cord-291950-9gtsqyfj	565	2	only	only	JJ
cord-291950-9gtsqyfj	565	3	cleavage	cleavage	NN
cord-291950-9gtsqyfj	565	4	performed	perform	VBN
cord-291950-9gtsqyfj	565	5	by	by	IN
cord-291950-9gtsqyfj	565	6	the	the	DT
cord-291950-9gtsqyfj	565	7	helper	helper	NN
cord-291950-9gtsqyfj	565	8	-	-	HYPH
cord-291950-9gtsqyfj	565	9	component	component	NN
cord-291950-9gtsqyfj	565	10	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	565	11	is	be	VBZ
cord-291950-9gtsqyfj	565	12	its	-PRON-	PRP$
cord-291950-9gtsqyfj	565	13	own	own	JJ
cord-291950-9gtsqyfj	565	14	release	release	NN
cord-291950-9gtsqyfj	565	15	from	from	IN
cord-291950-9gtsqyfj	565	16	the	the	DT
cord-291950-9gtsqyfj	565	17	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	565	18	by	by	IN
cord-291950-9gtsqyfj	565	19	cleavage	cleavage	NN
cord-291950-9gtsqyfj	565	20	of	of	IN
cord-291950-9gtsqyfj	565	21	a	a	DT
cord-291950-9gtsqyfj	565	22	GlykGly	GlykGly	NNP
cord-291950-9gtsqyfj	565	23	bond	bond	NN
cord-291950-9gtsqyfj	565	24	;	;	:
cord-291950-9gtsqyfj	565	25	further	further	JJ
cord-291950-9gtsqyfj	565	26	processing	processing	NN
cord-291950-9gtsqyfj	565	27	is	be	VBZ
cord-291950-9gtsqyfj	565	28	performed	perform	VBN
cord-291950-9gtsqyfj	565	29	by	by	IN
cord-291950-9gtsqyfj	565	30	the	the	DT
cord-291950-9gtsqyfj	565	31	serine	serine	NN
cord-291950-9gtsqyfj	565	32	-	-	HYPH
cord-291950-9gtsqyfj	565	33	type	type	NN
cord-291950-9gtsqyfj	565	34	P1	P1	NNP
cord-291950-9gtsqyfj	565	35	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	565	36	(	(	-LRB-
cord-291950-9gtsqyfj	565	37	Chapter	chapter	NN
cord-291950-9gtsqyfj	565	38	689	689	CD
cord-291950-9gtsqyfj	565	39	)	)	-RRB-
cord-291950-9gtsqyfj	565	40	.	.	.
cord-291950-9gtsqyfj	566	1	The	the	DT
cord-291950-9gtsqyfj	566	2	helper	helper	NN
cord-291950-9gtsqyfj	566	3	-	-	HYPH
cord-291950-9gtsqyfj	566	4	component	component	NN
cord-291950-9gtsqyfj	566	5	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	566	6	is	be	VBZ
cord-291950-9gtsqyfj	566	7	a	a	DT
cord-291950-9gtsqyfj	566	8	two	two	CD
cord-291950-9gtsqyfj	566	9	-	-	HYPH
cord-291950-9gtsqyfj	566	10	part	part	NN
cord-291950-9gtsqyfj	566	11	molecule	molecule	NN
cord-291950-9gtsqyfj	566	12	with	with	IN
cord-291950-9gtsqyfj	566	13	the	the	DT
cord-291950-9gtsqyfj	566	14	peptidase	peptidase	NN
cord-291950-9gtsqyfj	566	15	unit	unit	NN
cord-291950-9gtsqyfj	566	16	at	at	IN
cord-291950-9gtsqyfj	566	17	the	the	DT
cord-291950-9gtsqyfj	566	18	C	C	NNP
cord-291950-9gtsqyfj	566	19	-	-	HYPH
cord-291950-9gtsqyfj	566	20	terminus	terminus	NN
cord-291950-9gtsqyfj	566	21	,	,	,
cord-291950-9gtsqyfj	566	22	and	and	CC
cord-291950-9gtsqyfj	566	23	the	the	DT
cord-291950-9gtsqyfj	566	24	helper	helper	NN
cord-291950-9gtsqyfj	566	25	component	component	NN
cord-291950-9gtsqyfj	566	26	,	,	,
cord-291950-9gtsqyfj	566	27	required	require	VBN
cord-291950-9gtsqyfj	566	28	for	for	IN
cord-291950-9gtsqyfj	566	29	virus	virus	NN
cord-291950-9gtsqyfj	566	30	transmission	transmission	NN
cord-291950-9gtsqyfj	566	31	from	from	IN
cord-291950-9gtsqyfj	566	32	plant	plant	NN
cord-291950-9gtsqyfj	566	33	to	to	TO
cord-291950-9gtsqyfj	566	34	plant	plant	VB
cord-291950-9gtsqyfj	566	35	by	by	IN
cord-291950-9gtsqyfj	566	36	aphids	aphid	NNS
cord-291950-9gtsqyfj	566	37	,	,	,
cord-291950-9gtsqyfj	566	38	at	at	IN
cord-291950-9gtsqyfj	566	39	the	the	DT
cord-291950-9gtsqyfj	566	40	N	n	CD
cord-291950-9gtsqyfj	566	41	-	-	HYPH
cord-291950-9gtsqyfj	566	42	terminus	terminus	NN
cord-291950-9gtsqyfj	566	43	.	.	.
cord-291950-9gtsqyfj	567	1	The	the	DT
cord-291950-9gtsqyfj	567	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	567	3	residues	residue	NNS
cord-291950-9gtsqyfj	567	4	have	have	VBP
cord-291950-9gtsqyfj	567	5	been	be	VBN
cord-291950-9gtsqyfj	567	6	identified	identify	VBN
cord-291950-9gtsqyfj	567	7	by	by	IN
cord-291950-9gtsqyfj	567	8	site	site	NN
cord-291950-9gtsqyfj	567	9	-	-	HYPH
cord-291950-9gtsqyfj	567	10	directed	direct	VBN
cord-291950-9gtsqyfj	567	11	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	567	12	in	in	IN
cord-291950-9gtsqyfj	567	13	tobacco	tobacco	NN
cord-291950-9gtsqyfj	567	14	etch	etch	NN
cord-291950-9gtsqyfj	567	15	virus	virus	NN
cord-291950-9gtsqyfj	567	16	[	[	-LRB-
cord-291950-9gtsqyfj	567	17	103	103	CD
cord-291950-9gtsqyfj	567	18	]	]	-RRB-
cord-291950-9gtsqyfj	567	19	.	.	.
cord-291950-9gtsqyfj	568	1	Families	family	NNS
cord-291950-9gtsqyfj	568	2	C7	C7	NNP
cord-291950-9gtsqyfj	568	3	and	and	CC
cord-291950-9gtsqyfj	568	4	C8	C8	NNP
cord-291950-9gtsqyfj	568	5	contain	contain	VBP
cord-291950-9gtsqyfj	568	6	the	the	DT
cord-291950-9gtsqyfj	568	7	chestnut	chestnut	NN
cord-291950-9gtsqyfj	568	8	blight	blight	NN
cord-291950-9gtsqyfj	568	9	hypovirus	hypovirus	NNP
cord-291950-9gtsqyfj	568	10	endopeptidases	endopeptidases	NNPS
cord-291950-9gtsqyfj	568	11	p29	p29	NNP
cord-291950-9gtsqyfj	568	12	and	and	CC
cord-291950-9gtsqyfj	568	13	p48	p48	NN
cord-291950-9gtsqyfj	568	14	.	.	.
cord-291950-9gtsqyfj	569	1	Chestnut	chestnut	NN
cord-291950-9gtsqyfj	569	2	blight	blight	NN
cord-291950-9gtsqyfj	569	3	is	be	VBZ
cord-291950-9gtsqyfj	569	4	caused	cause	VBN
cord-291950-9gtsqyfj	569	5	by	by	IN
cord-291950-9gtsqyfj	569	6	the	the	DT
cord-291950-9gtsqyfj	569	7	fungus	fungus	NN
cord-291950-9gtsqyfj	569	8	Cryphonectria	Cryphonectria	NNP
cord-291950-9gtsqyfj	569	9	parasitica	parasitica	NNP
cord-291950-9gtsqyfj	569	10	,	,	,
cord-291950-9gtsqyfj	569	11	but	but	CC
cord-291950-9gtsqyfj	569	12	the	the	DT
cord-291950-9gtsqyfj	569	13	symptoms	symptom	NNS
cord-291950-9gtsqyfj	569	14	are	be	VBP
cord-291950-9gtsqyfj	569	15	reduced	reduce	VBN
cord-291950-9gtsqyfj	569	16	if	if	IN
cord-291950-9gtsqyfj	569	17	the	the	DT
cord-291950-9gtsqyfj	569	18	fungus	fungus	NN
cord-291950-9gtsqyfj	569	19	is	be	VBZ
cord-291950-9gtsqyfj	569	20	infected	infect	VBN
cord-291950-9gtsqyfj	569	21	by	by	IN
cord-291950-9gtsqyfj	569	22	the	the	DT
cord-291950-9gtsqyfj	569	23	double	double	RB
cord-291950-9gtsqyfj	569	24	-	-	HYPH
cord-291950-9gtsqyfj	569	25	stranded	strand	VBN
cord-291950-9gtsqyfj	569	26	RNA	RNA	NNP
cord-291950-9gtsqyfj	569	27	hypovirus	hypovirus	NNP
cord-291950-9gtsqyfj	569	28	.	.	.
cord-291950-9gtsqyfj	570	1	The	the	DT
cord-291950-9gtsqyfj	570	2	virus	virus	NN
cord-291950-9gtsqyfj	570	3	encodes	encode	VBZ
cord-291950-9gtsqyfj	570	4	two	two	CD
cord-291950-9gtsqyfj	570	5	polyproteins	polyprotein	NNS
cord-291950-9gtsqyfj	570	6	,	,	,
cord-291950-9gtsqyfj	570	7	and	and	CC
cord-291950-9gtsqyfj	570	8	the	the	DT
cord-291950-9gtsqyfj	570	9	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	570	10	responsible	responsible	JJ
cord-291950-9gtsqyfj	570	11	for	for	IN
cord-291950-9gtsqyfj	570	12	their	-PRON-	PRP$
cord-291950-9gtsqyfj	570	13	processing	processing	NN
cord-291950-9gtsqyfj	570	14	constitute	constitute	VBP
cord-291950-9gtsqyfj	570	15	the	the	DT
cord-291950-9gtsqyfj	570	16	smaller	small	JJR
cord-291950-9gtsqyfj	570	17	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	570	18	.	.	.
cord-291950-9gtsqyfj	571	1	The	the	DT
cord-291950-9gtsqyfj	571	2	p29	p29	NN
cord-291950-9gtsqyfj	571	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	571	4	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	571	5	a	a	DT
cord-291950-9gtsqyfj	571	6	single	single	JJ
cord-291950-9gtsqyfj	571	7	GlykGly	GlykGly	NNP
cord-291950-9gtsqyfj	571	8	bond	bond	NN
cord-291950-9gtsqyfj	571	9	in	in	IN
cord-291950-9gtsqyfj	571	10	the	the	DT
cord-291950-9gtsqyfj	571	11	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	571	12	to	to	TO
cord-291950-9gtsqyfj	571	13	release	release	VB
cord-291950-9gtsqyfj	571	14	itself	-PRON-	PRP
cord-291950-9gtsqyfj	571	15	and	and	CC
cord-291950-9gtsqyfj	571	16	the	the	DT
cord-291950-9gtsqyfj	571	17	p48	p48	NN
cord-291950-9gtsqyfj	571	18	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	571	19	[	[	-LRB-
cord-291950-9gtsqyfj	571	20	104	104	CD
cord-291950-9gtsqyfj	571	21	]	]	-RRB-
cord-291950-9gtsqyfj	571	22	.	.	.
cord-291950-9gtsqyfj	572	1	The	the	DT
cord-291950-9gtsqyfj	572	2	p48	p48	NN
cord-291950-9gtsqyfj	572	3	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	572	4	cleaves	cleave	VBZ
cord-291950-9gtsqyfj	572	5	a	a	DT
cord-291950-9gtsqyfj	572	6	single	single	JJ
cord-291950-9gtsqyfj	572	7	GlykAla	GlykAla	NNP
cord-291950-9gtsqyfj	572	8	bond	bond	NN
cord-291950-9gtsqyfj	572	9	in	in	IN
cord-291950-9gtsqyfj	572	10	the	the	DT
cord-291950-9gtsqyfj	572	11	larger	large	JJR
cord-291950-9gtsqyfj	572	12	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	572	13	[	[	-LRB-
cord-291950-9gtsqyfj	572	14	105	105	CD
cord-291950-9gtsqyfj	572	15	]	]	-RRB-
cord-291950-9gtsqyfj	572	16	.	.	.
cord-291950-9gtsqyfj	573	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	573	2	residues	residue	NNS
cord-291950-9gtsqyfj	573	3	have	have	VBP
cord-291950-9gtsqyfj	573	4	been	be	VBN
cord-291950-9gtsqyfj	573	5	identified	identify	VBN
cord-291950-9gtsqyfj	573	6	by	by	IN
cord-291950-9gtsqyfj	573	7	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	573	8	for	for	IN
cord-291950-9gtsqyfj	573	9	both	both	DT
cord-291950-9gtsqyfj	573	10	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	573	11	[	[	-LRB-
cord-291950-9gtsqyfj	573	12	105	105	CD
cord-291950-9gtsqyfj	573	13	,	,	,
cord-291950-9gtsqyfj	573	14	106	106	CD
cord-291950-9gtsqyfj	573	15	]	]	-RRB-
cord-291950-9gtsqyfj	573	16	.	.	.
cord-291950-9gtsqyfj	574	1	The	the	DT
cord-291950-9gtsqyfj	574	2	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	574	3	show	show	VBP
cord-291950-9gtsqyfj	574	4	no	no	DT
cord-291950-9gtsqyfj	574	5	significant	significant	JJ
cord-291950-9gtsqyfj	574	6	sequence	sequence	NN
cord-291950-9gtsqyfj	574	7	similarity	similarity	NN
cord-291950-9gtsqyfj	574	8	to	to	IN
cord-291950-9gtsqyfj	574	9	any	any	DT
cord-291950-9gtsqyfj	574	10	other	other	JJ
cord-291950-9gtsqyfj	574	11	peptidase	peptidase	NN
cord-291950-9gtsqyfj	574	12	,	,	,
cord-291950-9gtsqyfj	574	13	and	and	CC
cord-291950-9gtsqyfj	574	14	each	each	DT
cord-291950-9gtsqyfj	574	15	is	be	VBZ
cord-291950-9gtsqyfj	574	16	considered	consider	VBN
cord-291950-9gtsqyfj	574	17	a	a	DT
cord-291950-9gtsqyfj	574	18	representative	representative	NN
cord-291950-9gtsqyfj	574	19	of	of	IN
cord-291950-9gtsqyfj	574	20	a	a	DT
cord-291950-9gtsqyfj	574	21	distinct	distinct	JJ
cord-291950-9gtsqyfj	574	22	family	family	NN
cord-291950-9gtsqyfj	574	23	,	,	,
cord-291950-9gtsqyfj	574	24	although	although	IN
cord-291950-9gtsqyfj	574	25	there	there	EX
cord-291950-9gtsqyfj	574	26	is	be	VBZ
cord-291950-9gtsqyfj	574	27	conservation	conservation	NN
cord-291950-9gtsqyfj	574	28	of	of	IN
cord-291950-9gtsqyfj	574	29	a	a	DT
cord-291950-9gtsqyfj	574	30	Gly	Gly	NNP
cord-291950-9gtsqyfj	574	31	-	-	HYPH
cord-291950-9gtsqyfj	574	32	Tyr	Tyr	NNP
cord-291950-9gtsqyfj	574	33	-	-	HYPH
cord-291950-9gtsqyfj	574	34	Cys	Cys	NNP
cord-291950-9gtsqyfj	574	35	-	-	HYPH
cord-291950-9gtsqyfj	574	36	Tyr	Tyr	NNP
cord-291950-9gtsqyfj	574	37	motif	motif	NN
cord-291950-9gtsqyfj	574	38	containing	contain	VBG
cord-291950-9gtsqyfj	574	39	the	the	DT
cord-291950-9gtsqyfj	574	40	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	574	41	Cys	Cys	NNP
cord-291950-9gtsqyfj	574	42	between	between	IN
cord-291950-9gtsqyfj	574	43	the	the	DT
cord-291950-9gtsqyfj	574	44	p29	p29	NNP
cord-291950-9gtsqyfj	574	45	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	574	46	(	(	-LRB-
cord-291950-9gtsqyfj	574	47	family	family	NN
cord-291950-9gtsqyfj	574	48	C7	C7	NNP
cord-291950-9gtsqyfj	574	49	)	)	-RRB-
cord-291950-9gtsqyfj	574	50	and	and	CC
cord-291950-9gtsqyfj	574	51	family	family	NN
cord-291950-9gtsqyfj	574	52	C6	c6	NN
cord-291950-9gtsqyfj	574	53	.	.	.
cord-291950-9gtsqyfj	575	1	Family	Family	NNP
cord-291950-9gtsqyfj	575	2	C21	C21	NNP
cord-291950-9gtsqyfj	575	3	contains	contain	VBZ
cord-291950-9gtsqyfj	575	4	the	the	DT
cord-291950-9gtsqyfj	575	5	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	575	6	-	-	HYPH
cord-291950-9gtsqyfj	575	7	processing	process	VBG
cord-291950-9gtsqyfj	575	8	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	575	9	from	from	IN
cord-291950-9gtsqyfj	575	10	tymoviruses	tymoviruse	NNS
cord-291950-9gtsqyfj	575	11	.	.	.
cord-291950-9gtsqyfj	576	1	The	the	DT
cord-291950-9gtsqyfj	576	2	206	206	CD
cord-291950-9gtsqyfj	576	3	kDa	kDa	NNP
cord-291950-9gtsqyfj	576	4	polyprotein	polyprotein	NNP
cord-291950-9gtsqyfj	576	5	is	be	VBZ
cord-291950-9gtsqyfj	576	6	cleaved	cleave	VBN
cord-291950-9gtsqyfj	576	7	at	at	IN
cord-291950-9gtsqyfj	576	8	an	an	DT
cord-291950-9gtsqyfj	576	9	AlakThr	AlakThr	NNP
cord-291950-9gtsqyfj	576	10	bond	bond	NN
cord-291950-9gtsqyfj	576	11	[	[	-LRB-
cord-291950-9gtsqyfj	576	12	107	107	CD
cord-291950-9gtsqyfj	576	13	]	]	-RRB-
cord-291950-9gtsqyfj	576	14	to	to	TO
cord-291950-9gtsqyfj	576	15	release	release	VB
cord-291950-9gtsqyfj	576	16	the	the	DT
cord-291950-9gtsqyfj	576	17	70	70	CD
cord-291950-9gtsqyfj	576	18	kDa	kDa	NNP
cord-291950-9gtsqyfj	576	19	polymerase	polymerase	NN
cord-291950-9gtsqyfj	576	20	from	from	IN
cord-291950-9gtsqyfj	576	21	the	the	DT
cord-291950-9gtsqyfj	576	22	C	C	NNP
cord-291950-9gtsqyfj	576	23	-	-	HYPH
cord-291950-9gtsqyfj	576	24	terminus	terminus	NN
cord-291950-9gtsqyfj	576	25	and	and	CC
cord-291950-9gtsqyfj	576	26	a	a	DT
cord-291950-9gtsqyfj	576	27	150	150	CD
cord-291950-9gtsqyfj	576	28	kDa	kda	NN
cord-291950-9gtsqyfj	576	29	protein	protein	NN
cord-291950-9gtsqyfj	576	30	FIGURE	figure	NN
cord-291950-9gtsqyfj	576	31	404.38	404.38	CD
cord-291950-9gtsqyfj	576	32	Richardson	Richardson	NNP
cord-291950-9gtsqyfj	576	33	diagram	diagram	NN
cord-291950-9gtsqyfj	576	34	of	of	IN
cord-291950-9gtsqyfj	576	35	the	the	DT
cord-291950-9gtsqyfj	576	36	NLP	NLP	NNP
cord-291950-9gtsqyfj	576	37	/	/	SYM
cord-291950-9gtsqyfj	576	38	P60-like	P60-like	NNP
cord-291950-9gtsqyfj	576	39	putative	putative	JJ
cord-291950-9gtsqyfj	576	40	peptidase	peptidase	NN
cord-291950-9gtsqyfj	576	41	from	from	IN
cord-291950-9gtsqyfj	576	42	Nostoc	Nostoc	NNP
cord-291950-9gtsqyfj	576	43	punctiforme	punctiforme	NNP
cord-291950-9gtsqyfj	576	44	.	.	.
cord-291950-9gtsqyfj	577	1	The	the	DT
cord-291950-9gtsqyfj	577	2	image	image	NN
cord-291950-9gtsqyfj	577	3	was	be	VBD
cord-291950-9gtsqyfj	577	4	prepared	prepare	VBN
cord-291950-9gtsqyfj	577	5	from	from	IN
cord-291950-9gtsqyfj	577	6	the	the	DT
cord-291950-9gtsqyfj	577	7	Protein	Protein	NNP
cord-291950-9gtsqyfj	577	8	Data	Data	NNP
cord-291950-9gtsqyfj	577	9	Bank	Bank	NNP
cord-291950-9gtsqyfj	577	10	entry	entry	NN
cord-291950-9gtsqyfj	577	11	(	(	-LRB-
cord-291950-9gtsqyfj	577	12	2EVR	2evr	LS
cord-291950-9gtsqyfj	577	13	)	)	-RRB-
cord-291950-9gtsqyfj	577	14	as	as	IN
cord-291950-9gtsqyfj	577	15	described	describe	VBN
cord-291950-9gtsqyfj	577	16	in	in	IN
cord-291950-9gtsqyfj	577	17	the	the	DT
cord-291950-9gtsqyfj	577	18	Introduction	introduction	NN
cord-291950-9gtsqyfj	577	19	(	(	-LRB-
cord-291950-9gtsqyfj	577	20	p.	p.	NN
cord-291950-9gtsqyfj	577	21	li	li	NNP
cord-291950-9gtsqyfj	577	22	)	)	-RRB-
cord-291950-9gtsqyfj	577	23	.	.	.
cord-291950-9gtsqyfj	578	1	Catalytic	catalytic	JJ
cord-291950-9gtsqyfj	578	2	residues	residue	NNS
cord-291950-9gtsqyfj	578	3	are	be	VBP
cord-291950-9gtsqyfj	578	4	shown	show	VBN
cord-291950-9gtsqyfj	578	5	in	in	IN
cord-291950-9gtsqyfj	578	6	ball	ball	NN
cord-291950-9gtsqyfj	578	7	-	-	HYPH
cord-291950-9gtsqyfj	578	8	and	and	CC
cord-291950-9gtsqyfj	578	9	-	-	HYPH
cord-291950-9gtsqyfj	578	10	stick	stick	NN
cord-291950-9gtsqyfj	578	11	representation	representation	NN
cord-291950-9gtsqyfj	578	12	:	:	:
cord-291950-9gtsqyfj	578	13	His184	his184	CD
cord-291950-9gtsqyfj	578	14	and	and	CC
cord-291950-9gtsqyfj	578	15	His196	his196	ADD
cord-291950-9gtsqyfj	578	16	in	in	IN
cord-291950-9gtsqyfj	578	17	purple	purple	NN
cord-291950-9gtsqyfj	578	18	and	and	CC
cord-291950-9gtsqyfj	578	19	Cys134	cys134	DT
cord-291950-9gtsqyfj	578	20	in	in	IN
cord-291950-9gtsqyfj	578	21	yellow	yellow	JJ
cord-291950-9gtsqyfj	578	22	(	(	-LRB-
cord-291950-9gtsqyfj	578	23	numbering	number	VBG
cord-291950-9gtsqyfj	578	24	as	as	IN
cord-291950-9gtsqyfj	578	25	in	in	IN
cord-291950-9gtsqyfj	578	26	PDB	PDB	NNP
cord-291950-9gtsqyfj	578	27	entry	entry	NN
cord-291950-9gtsqyfj	578	28	)	)	-RRB-
cord-291950-9gtsqyfj	578	29	.	.	.
cord-291950-9gtsqyfj	579	1	that	that	DT
cord-291950-9gtsqyfj	579	2	includes	include	VBZ
cord-291950-9gtsqyfj	579	3	the	the	DT
cord-291950-9gtsqyfj	579	4	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	579	5	and	and	CC
cord-291950-9gtsqyfj	579	6	a	a	DT
cord-291950-9gtsqyfj	579	7	helicase	helicase	NN
cord-291950-9gtsqyfj	579	8	from	from	IN
cord-291950-9gtsqyfj	579	9	the	the	DT
cord-291950-9gtsqyfj	579	10	N	N	NNP
cord-291950-9gtsqyfj	579	11	-	-	HYPH
cord-291950-9gtsqyfj	579	12	terminus	terminus	NN
cord-291950-9gtsqyfj	579	13	.	.	.
cord-291950-9gtsqyfj	580	1	The	the	DT
cord-291950-9gtsqyfj	580	2	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	580	3	residues	residue	NNS
cord-291950-9gtsqyfj	580	4	have	have	VBP
cord-291950-9gtsqyfj	580	5	been	be	VBN
cord-291950-9gtsqyfj	580	6	identified	identify	VBN
cord-291950-9gtsqyfj	580	7	by	by	IN
cord-291950-9gtsqyfj	580	8	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	580	9	[	[	-LRB-
cord-291950-9gtsqyfj	580	10	108	108	CD
cord-291950-9gtsqyfj	580	11	]	]	-RRB-
cord-291950-9gtsqyfj	580	12	.	.	.
cord-291950-9gtsqyfj	581	1	Family	Family	NNP
cord-291950-9gtsqyfj	581	2	C23	C23	NNP
cord-291950-9gtsqyfj	581	3	includes	include	VBZ
cord-291950-9gtsqyfj	581	4	the	the	DT
cord-291950-9gtsqyfj	581	5	p223	p223	NNP
cord-291950-9gtsqyfj	581	6	polyprotein	polyprotein	NNP
cord-291950-9gtsqyfj	581	7	processing	processing	NN
cord-291950-9gtsqyfj	581	8	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	581	9	from	from	IN
cord-291950-9gtsqyfj	581	10	the	the	DT
cord-291950-9gtsqyfj	581	11	blueberry	blueberry	NN
cord-291950-9gtsqyfj	581	12	scorch	scorch	VBP
cord-291950-9gtsqyfj	581	13	virus	virus	NN
cord-291950-9gtsqyfj	581	14	.	.	.
cord-291950-9gtsqyfj	582	1	Cleavage	cleavage	NN
cord-291950-9gtsqyfj	582	2	is	be	VBZ
cord-291950-9gtsqyfj	582	3	at	at	IN
cord-291950-9gtsqyfj	582	4	a	a	DT
cord-291950-9gtsqyfj	582	5	single	single	JJ
cord-291950-9gtsqyfj	582	6	GlykAla	GlykAla	NNP
cord-291950-9gtsqyfj	582	7	bond	bond	NN
cord-291950-9gtsqyfj	582	8	,	,	,
cord-291950-9gtsqyfj	582	9	and	and	CC
cord-291950-9gtsqyfj	582	10	site	site	NN
cord-291950-9gtsqyfj	582	11	-	-	HYPH
cord-291950-9gtsqyfj	582	12	directed	direct	VBN
cord-291950-9gtsqyfj	582	13	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	582	14	has	have	VBZ
cord-291950-9gtsqyfj	582	15	been	be	VBN
cord-291950-9gtsqyfj	582	16	used	use	VBN
cord-291950-9gtsqyfj	582	17	to	to	TO
cord-291950-9gtsqyfj	582	18	identify	identify	VB
cord-291950-9gtsqyfj	582	19	the	the	DT
cord-291950-9gtsqyfj	582	20	potential	potential	JJ
cord-291950-9gtsqyfj	582	21	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	582	22	residues	residue	NNS
cord-291950-9gtsqyfj	582	23	[	[	-LRB-
cord-291950-9gtsqyfj	582	24	109	109	CD
cord-291950-9gtsqyfj	582	25	]	]	-RRB-
cord-291950-9gtsqyfj	582	26	.	.	.
cord-291950-9gtsqyfj	583	1	Family	Family	NNP
cord-291950-9gtsqyfj	583	2	C27	C27	NNP
cord-291950-9gtsqyfj	583	3	includes	include	VBZ
cord-291950-9gtsqyfj	583	4	the	the	DT
cord-291950-9gtsqyfj	583	5	non	non	JJ
cord-291950-9gtsqyfj	583	6	-	-	JJ
cord-291950-9gtsqyfj	583	7	structural	structural	JJ
cord-291950-9gtsqyfj	583	8	polyproteinprocessing	polyproteinprocesse	VBG
cord-291950-9gtsqyfj	583	9	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	583	10	from	from	IN
cord-291950-9gtsqyfj	583	11	rubella	rubella	NN
cord-291950-9gtsqyfj	583	12	virus	virus	NN
cord-291950-9gtsqyfj	583	13	.	.	.
cord-291950-9gtsqyfj	584	1	Processing	processing	NN
cord-291950-9gtsqyfj	584	2	occurs	occur	VBZ
cord-291950-9gtsqyfj	584	3	at	at	IN
cord-291950-9gtsqyfj	584	4	a	a	DT
cord-291950-9gtsqyfj	584	5	single	single	JJ
cord-291950-9gtsqyfj	584	6	GlykGly	GlykGly	NNP
cord-291950-9gtsqyfj	584	7	bond	bond	NN
cord-291950-9gtsqyfj	584	8	,	,	,
cord-291950-9gtsqyfj	584	9	and	and	CC
cord-291950-9gtsqyfj	584	10	the	the	DT
cord-291950-9gtsqyfj	584	11	Cys	Cys	NNP
cord-291950-9gtsqyfj	584	12	,	,	,
cord-291950-9gtsqyfj	584	13	His	-PRON-	PRP$
cord-291950-9gtsqyfj	584	14	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	584	15	dyad	dyad	NN
cord-291950-9gtsqyfj	584	16	has	have	VBZ
cord-291950-9gtsqyfj	584	17	been	be	VBN
cord-291950-9gtsqyfj	584	18	identified	identify	VBN
cord-291950-9gtsqyfj	584	19	[	[	-LRB-
cord-291950-9gtsqyfj	584	20	110	110	CD
cord-291950-9gtsqyfj	584	21	]	]	-RRB-
cord-291950-9gtsqyfj	584	22	.	.	.
cord-291950-9gtsqyfj	585	1	Family	Family	NNP
cord-291950-9gtsqyfj	585	2	C36	C36	NNP
cord-291950-9gtsqyfj	585	3	is	be	VBZ
cord-291950-9gtsqyfj	585	4	represented	represent	VBN
cord-291950-9gtsqyfj	585	5	by	by	IN
cord-291950-9gtsqyfj	585	6	a	a	DT
cord-291950-9gtsqyfj	585	7	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	585	8	processing	processing	NN
cord-291950-9gtsqyfj	585	9	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	585	10	beet	beet	NN
cord-291950-9gtsqyfj	585	11	necrotic	necrotic	JJ
cord-291950-9gtsqyfj	585	12	yellow	yellow	JJ
cord-291950-9gtsqyfj	585	13	vein	vein	NN
cord-291950-9gtsqyfj	585	14	virus	virus	NN
cord-291950-9gtsqyfj	585	15	[	[	-LRB-
cord-291950-9gtsqyfj	585	16	111	111	CD
cord-291950-9gtsqyfj	585	17	]	]	-RRB-
cord-291950-9gtsqyfj	585	18	.	.	.
cord-291950-9gtsqyfj	586	1	Family	Family	NNP
cord-291950-9gtsqyfj	586	2	C42	C42	NNP
cord-291950-9gtsqyfj	586	3	includes	include	VBZ
cord-291950-9gtsqyfj	586	4	a	a	DT
cord-291950-9gtsqyfj	586	5	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	586	6	-	-	HYPH
cord-291950-9gtsqyfj	586	7	processing	process	VBG
cord-291950-9gtsqyfj	586	8	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	586	9	from	from	IN
cord-291950-9gtsqyfj	586	10	the	the	DT
cord-291950-9gtsqyfj	586	11	beet	beet	NN
cord-291950-9gtsqyfj	586	12	yellows	yellow	NNS
cord-291950-9gtsqyfj	586	13	closterovirus	closterovirus	NNP
cord-291950-9gtsqyfj	586	14	.	.	.
cord-291950-9gtsqyfj	587	1	Processing	processing	NN
cord-291950-9gtsqyfj	587	2	occurs	occur	VBZ
cord-291950-9gtsqyfj	587	3	at	at	IN
cord-291950-9gtsqyfj	587	4	a	a	DT
cord-291950-9gtsqyfj	587	5	single	single	JJ
cord-291950-9gtsqyfj	587	6	GlykGly	GlykGly	NNP
cord-291950-9gtsqyfj	587	7	bond	bond	NN
cord-291950-9gtsqyfj	587	8	,	,	,
cord-291950-9gtsqyfj	587	9	and	and	CC
cord-291950-9gtsqyfj	587	10	the	the	DT
cord-291950-9gtsqyfj	587	11	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	587	12	dyad	dyad	NN
cord-291950-9gtsqyfj	587	13	has	have	VBZ
cord-291950-9gtsqyfj	587	14	been	be	VBN
cord-291950-9gtsqyfj	587	15	identified	identify	VBN
cord-291950-9gtsqyfj	587	16	by	by	IN
cord-291950-9gtsqyfj	587	17	site	site	NN
cord-291950-9gtsqyfj	587	18	-	-	HYPH
cord-291950-9gtsqyfj	587	19	directed	direct	VBN
cord-291950-9gtsqyfj	587	20	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	587	21	[	[	-LRB-
cord-291950-9gtsqyfj	587	22	112	112	CD
cord-291950-9gtsqyfj	587	23	]	]	-RRB-
cord-291950-9gtsqyfj	587	24	.	.	.
cord-291950-9gtsqyfj	588	1	Family	Family	NNP
cord-291950-9gtsqyfj	588	2	C53	C53	NNP
cord-291950-9gtsqyfj	588	3	contains	contain	VBZ
cord-291950-9gtsqyfj	588	4	the	the	DT
cord-291950-9gtsqyfj	588	5	NPro	NPro	NNP
cord-291950-9gtsqyfj	588	6	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	588	7	of	of	IN
cord-291950-9gtsqyfj	588	8	pestiviruses	pestiviruse	NNS
cord-291950-9gtsqyfj	588	9	(	(	-LRB-
cord-291950-9gtsqyfj	588	10	Chapter	chapter	NN
cord-291950-9gtsqyfj	588	11	557	557	CD
cord-291950-9gtsqyfj	588	12	)	)	-RRB-
cord-291950-9gtsqyfj	588	13	.	.	.
cord-291950-9gtsqyfj	589	1	Pestiviruses	pestiviruse	NNS
cord-291950-9gtsqyfj	589	2	possess	possess	VBP
cord-291950-9gtsqyfj	589	3	two	two	CD
cord-291950-9gtsqyfj	589	4	polyprotein	polyprotein	JJ
cord-291950-9gtsqyfj	589	5	-	-	HYPH
cord-291950-9gtsqyfj	589	6	processing	processing	NN
cord-291950-9gtsqyfj	589	7	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	589	8	:	:	:
cord-291950-9gtsqyfj	589	9	the	the	DT
cord-291950-9gtsqyfj	589	10	serine	serine	NN
cord-291950-9gtsqyfj	589	11	-	-	HYPH
cord-291950-9gtsqyfj	589	12	type	type	NN
cord-291950-9gtsqyfj	589	13	NS2	NS2	NNP
cord-291950-9gtsqyfj	589	14	-	-	HYPH
cord-291950-9gtsqyfj	589	15	3	3	CD
cord-291950-9gtsqyfj	589	16	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	589	17	(	(	-LRB-
cord-291950-9gtsqyfj	589	18	Chapter	chapter	NN
cord-291950-9gtsqyfj	589	19	554	554	CD
cord-291950-9gtsqyfj	589	20	)	)	-RRB-
cord-291950-9gtsqyfj	589	21	,	,	,
cord-291950-9gtsqyfj	589	22	which	which	WDT
cord-291950-9gtsqyfj	589	23	is	be	VBZ
cord-291950-9gtsqyfj	589	24	the	the	DT
cord-291950-9gtsqyfj	589	25	more	more	RBR
cord-291950-9gtsqyfj	589	26	general	general	JJ
cord-291950-9gtsqyfj	589	27	processing	processing	NN
cord-291950-9gtsqyfj	589	28	activity	activity	NN
cord-291950-9gtsqyfj	589	29	;	;	:
cord-291950-9gtsqyfj	589	30	and	and	CC
cord-291950-9gtsqyfj	589	31	the	the	DT
cord-291950-9gtsqyfj	589	32	NPro	NPro	NNP
cord-291950-9gtsqyfj	589	33	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	589	34	,	,	,
cord-291950-9gtsqyfj	589	35	which	which	WDT
cord-291950-9gtsqyfj	589	36	is	be	VBZ
cord-291950-9gtsqyfj	589	37	the	the	DT
cord-291950-9gtsqyfj	589	38	N	n	CD
cord-291950-9gtsqyfj	589	39	-	-	HYPH
cord-291950-9gtsqyfj	589	40	terminal	terminal	NN
cord-291950-9gtsqyfj	589	41	protein	protein	NN
cord-291950-9gtsqyfj	589	42	and	and	CC
cord-291950-9gtsqyfj	589	43	releases	release	VBZ
cord-291950-9gtsqyfj	589	44	itself	-PRON-	PRP
cord-291950-9gtsqyfj	589	45	from	from	IN
cord-291950-9gtsqyfj	589	46	the	the	DT
cord-291950-9gtsqyfj	589	47	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	589	48	by	by	IN
cord-291950-9gtsqyfj	589	49	autolytic	autolytic	JJ
cord-291950-9gtsqyfj	589	50	cleavage	cleavage	NN
cord-291950-9gtsqyfj	589	51	of	of	IN
cord-291950-9gtsqyfj	589	52	a	a	DT
cord-291950-9gtsqyfj	589	53	CyskSer	CyskSer	NNP
cord-291950-9gtsqyfj	589	54	bond	bond	NN
cord-291950-9gtsqyfj	589	55	.	.	.
cord-291950-9gtsqyfj	590	1	The	the	DT
cord-291950-9gtsqyfj	590	2	residue	residue	NN
cord-291950-9gtsqyfj	590	3	Cys69	Cys69	NNP
cord-291950-9gtsqyfj	590	4	has	have	VBZ
cord-291950-9gtsqyfj	590	5	now	now	RB
cord-291950-9gtsqyfj	590	6	been	be	VBN
cord-291950-9gtsqyfj	590	7	identified	identify	VBN
cord-291950-9gtsqyfj	590	8	as	as	IN
cord-291950-9gtsqyfj	590	9	a	a	DT
cord-291950-9gtsqyfj	590	10	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	590	11	residue	residue	NN
cord-291950-9gtsqyfj	590	12	[	[	-LRB-
cord-291950-9gtsqyfj	590	13	113	113	CD
cord-291950-9gtsqyfj	590	14	]	]	-RRB-
cord-291950-9gtsqyfj	590	15	.	.	.
cord-291950-9gtsqyfj	591	1	Family	Family	NNP
cord-291950-9gtsqyfj	591	2	C75	C75	NNP
cord-291950-9gtsqyfj	591	3	includes	include	VBZ
cord-291950-9gtsqyfj	591	4	the	the	DT
cord-291950-9gtsqyfj	591	5	AgrB	AgrB	NNP
cord-291950-9gtsqyfj	591	6	protein	protein	NN
cord-291950-9gtsqyfj	591	7	from	from	IN
cord-291950-9gtsqyfj	591	8	Staphylococcus	Staphylococcus	NNP
cord-291950-9gtsqyfj	591	9	aureus	aureus	NN
cord-291950-9gtsqyfj	591	10	.	.	.
cord-291950-9gtsqyfj	592	1	The	the	DT
cord-291950-9gtsqyfj	592	2	agr	agr	NNP
cord-291950-9gtsqyfj	592	3	operon	operon	NN
cord-291950-9gtsqyfj	592	4	includes	include	VBZ
cord-291950-9gtsqyfj	592	5	four	four	CD
cord-291950-9gtsqyfj	592	6	genes	gene	NNS
cord-291950-9gtsqyfj	592	7	whose	whose	WP$
cord-291950-9gtsqyfj	592	8	products	product	NNS
cord-291950-9gtsqyfj	592	9	are	be	VBP
cord-291950-9gtsqyfj	592	10	involved	involve	VBN
cord-291950-9gtsqyfj	592	11	in	in	IN
cord-291950-9gtsqyfj	592	12	quorum	quorum	NN
cord-291950-9gtsqyfj	592	13	sensing	sensing	NN
cord-291950-9gtsqyfj	592	14	.	.	.
cord-291950-9gtsqyfj	593	1	The	the	DT
cord-291950-9gtsqyfj	593	2	ArgA	ArgA	NNP
cord-291950-9gtsqyfj	593	3	protein	protein	NN
cord-291950-9gtsqyfj	593	4	is	be	VBZ
cord-291950-9gtsqyfj	593	5	a	a	DT
cord-291950-9gtsqyfj	593	6	response	response	NN
cord-291950-9gtsqyfj	593	7	regulator	regulator	NN
cord-291950-9gtsqyfj	593	8	,	,	,
cord-291950-9gtsqyfj	593	9	ArgC	ArgC	NNP
cord-291950-9gtsqyfj	593	10	is	be	VBZ
cord-291950-9gtsqyfj	593	11	a	a	DT
cord-291950-9gtsqyfj	593	12	sensor	sensor	NN
cord-291950-9gtsqyfj	593	13	kinase	kinase	NN
cord-291950-9gtsqyfj	593	14	and	and	CC
cord-291950-9gtsqyfj	593	15	AgrD	AgrD	NNP
cord-291950-9gtsqyfj	594	1	is	be	VBZ
cord-291950-9gtsqyfj	594	2	a	a	DT
cord-291950-9gtsqyfj	594	3	polypeptide	polypeptide	NN
cord-291950-9gtsqyfj	594	4	that	that	WDT
cord-291950-9gtsqyfj	594	5	is	be	VBZ
cord-291950-9gtsqyfj	594	6	integrated	integrate	VBN
cord-291950-9gtsqyfj	594	7	into	into	IN
cord-291950-9gtsqyfj	594	8	the	the	DT
cord-291950-9gtsqyfj	594	9	cytoplasmic	cytoplasmic	JJ
cord-291950-9gtsqyfj	594	10	membrane	membrane	NN
cord-291950-9gtsqyfj	594	11	via	via	IN
cord-291950-9gtsqyfj	594	12	its	-PRON-	PRP$
cord-291950-9gtsqyfj	594	13	N	n	CD
cord-291950-9gtsqyfj	594	14	-	-	HYPH
cord-291950-9gtsqyfj	594	15	terminal	terminal	NN
cord-291950-9gtsqyfj	594	16	region	region	NN
cord-291950-9gtsqyfj	594	17	,	,	,
cord-291950-9gtsqyfj	594	18	and	and	CC
cord-291950-9gtsqyfj	594	19	is	be	VBZ
cord-291950-9gtsqyfj	594	20	the	the	DT
cord-291950-9gtsqyfj	594	21	precursor	precursor	NN
cord-291950-9gtsqyfj	594	22	for	for	IN
cord-291950-9gtsqyfj	594	23	an	an	DT
cord-291950-9gtsqyfj	594	24	autoinducing	autoinducing	NN
cord-291950-9gtsqyfj	594	25	peptide	peptide	NN
cord-291950-9gtsqyfj	594	26	(	(	-LRB-
cord-291950-9gtsqyfj	594	27	AIP	AIP	NNP
cord-291950-9gtsqyfj	594	28	)	)	-RRB-
cord-291950-9gtsqyfj	594	29	that	that	WDT
cord-291950-9gtsqyfj	594	30	is	be	VBZ
cord-291950-9gtsqyfj	594	31	the	the	DT
cord-291950-9gtsqyfj	594	32	ligand	ligand	NN
cord-291950-9gtsqyfj	594	33	for	for	IN
cord-291950-9gtsqyfj	594	34	AgrC.	AgrC.	NNP
cord-291950-9gtsqyfj	595	1	The	the	DT
cord-291950-9gtsqyfj	595	2	AgrB	AgrB	NNP
cord-291950-9gtsqyfj	595	3	protein	protein	NN
cord-291950-9gtsqyfj	595	4	is	be	VBZ
cord-291950-9gtsqyfj	595	5	the	the	DT
cord-291950-9gtsqyfj	595	6	peptidase	peptidase	NN
cord-291950-9gtsqyfj	595	7	that	that	WDT
cord-291950-9gtsqyfj	595	8	releases	release	VBZ
cord-291950-9gtsqyfj	595	9	AIP	AIP	NNP
cord-291950-9gtsqyfj	595	10	from	from	IN
cord-291950-9gtsqyfj	595	11	AgrD	AgrD	NNP
cord-291950-9gtsqyfj	595	12	[	[	-LRB-
cord-291950-9gtsqyfj	595	13	114	114	CD
cord-291950-9gtsqyfj	595	14	]	]	-RRB-
cord-291950-9gtsqyfj	595	15	,	,	,
cord-291950-9gtsqyfj	595	16	following	follow	VBG
cord-291950-9gtsqyfj	595	17	the	the	DT
cord-291950-9gtsqyfj	595	18	removal	removal	NN
cord-291950-9gtsqyfj	595	19	of	of	IN
cord-291950-9gtsqyfj	595	20	an	an	DT
cord-291950-9gtsqyfj	595	21	N	n	CD
cord-291950-9gtsqyfj	595	22	-	-	HYPH
cord-291950-9gtsqyfj	595	23	terminal	terminal	NN
cord-291950-9gtsqyfj	595	24	peptide	peptide	NN
cord-291950-9gtsqyfj	595	25	by	by	IN
cord-291950-9gtsqyfj	595	26	type	type	NN
cord-291950-9gtsqyfj	595	27	I	-PRON-	PRP
cord-291950-9gtsqyfj	595	28	signal	signal	VBP
cord-291950-9gtsqyfj	595	29	peptidase	peptidase	NN
cord-291950-9gtsqyfj	595	30	[	[	-LRB-
cord-291950-9gtsqyfj	595	31	115	115	CD
cord-291950-9gtsqyfj	595	32	]	]	-RRB-
cord-291950-9gtsqyfj	595	33	.	.	.
cord-291950-9gtsqyfj	596	1	The	the	DT
cord-291950-9gtsqyfj	596	2	active	active	JJ
cord-291950-9gtsqyfj	596	3	site	site	NN
cord-291950-9gtsqyfj	596	4	residues	residue	NNS
cord-291950-9gtsqyfj	596	5	His77	His77	NNP
cord-291950-9gtsqyfj	596	6	and	and	CC
cord-291950-9gtsqyfj	596	7	Cys84	Cys84	NNP
cord-291950-9gtsqyfj	596	8	were	be	VBD
cord-291950-9gtsqyfj	596	9	identified	identify	VBN
cord-291950-9gtsqyfj	596	10	in	in	IN
cord-291950-9gtsqyfj	596	11	Staphylococcus	Staphylococcus	NNP
cord-291950-9gtsqyfj	596	12	aureus	aureus	NN
cord-291950-9gtsqyfj	596	13	AgrB	AgrB	NNP
cord-291950-9gtsqyfj	596	14	by	by	IN
cord-291950-9gtsqyfj	596	15	[	[	-LRB-
cord-291950-9gtsqyfj	596	16	114	114	CD
cord-291950-9gtsqyfj	596	17	]	]	-RRB-
cord-291950-9gtsqyfj	596	18	.	.	.
cord-291950-9gtsqyfj	597	1	AgrB	AgrB	NNP
cord-291950-9gtsqyfj	597	2	is	be	VBZ
cord-291950-9gtsqyfj	597	3	an	an	DT
cord-291950-9gtsqyfj	597	4	integral	integral	JJ
cord-291950-9gtsqyfj	597	5	membrane	membrane	NN
cord-291950-9gtsqyfj	597	6	protein	protein	NN
cord-291950-9gtsqyfj	597	7	,	,	,
cord-291950-9gtsqyfj	597	8	with	with	IN
cord-291950-9gtsqyfj	597	9	the	the	DT
cord-291950-9gtsqyfj	597	10	active	active	JJ
cord-291950-9gtsqyfj	597	11	site	site	NN
cord-291950-9gtsqyfj	597	12	close	close	RB
cord-291950-9gtsqyfj	597	13	to	to	IN
cord-291950-9gtsqyfj	597	14	the	the	DT
cord-291950-9gtsqyfj	597	15	cytoplasm	cytoplasm	NN
cord-291950-9gtsqyfj	597	16	[	[	-LRB-
cord-291950-9gtsqyfj	597	17	116	116	CD
cord-291950-9gtsqyfj	597	18	]	]	-RRB-
cord-291950-9gtsqyfj	597	19	.	.	.
cord-291950-9gtsqyfj	598	1	Inhibition	inhibition	NN
cord-291950-9gtsqyfj	598	2	of	of	IN
cord-291950-9gtsqyfj	598	3	mammalian	mammalian	JJ
cord-291950-9gtsqyfj	598	4	legumain	legumain	NN
cord-291950-9gtsqyfj	598	5	by	by	IN
cord-291950-9gtsqyfj	598	6	some	some	DT
cord-291950-9gtsqyfj	598	7	cystatins	cystatin	NNS
cord-291950-9gtsqyfj	598	8	is	be	VBZ
cord-291950-9gtsqyfj	598	9	due	due	JJ
cord-291950-9gtsqyfj	598	10	to	to	IN
cord-291950-9gtsqyfj	598	11	a	a	DT
cord-291950-9gtsqyfj	598	12	novel	novel	JJ
cord-291950-9gtsqyfj	598	13	second	second	JJ
cord-291950-9gtsqyfj	598	14	reactive	reactive	JJ
cord-291950-9gtsqyfj	598	15	site	site	NN
cord-291950-9gtsqyfj	598	16	BJ46a	BJ46a	NNS
cord-291950-9gtsqyfj	598	17	,	,	,
cord-291950-9gtsqyfj	598	18	a	a	DT
cord-291950-9gtsqyfj	598	19	snake	snake	NN
cord-291950-9gtsqyfj	598	20	venom	venom	NN
cord-291950-9gtsqyfj	598	21	metalloproteinase	metalloproteinase	NN
cord-291950-9gtsqyfj	598	22	inhibitor	inhibitor	NN
cord-291950-9gtsqyfj	598	23	.	.	.
cord-291950-9gtsqyfj	599	1	Isolation	isolation	NN
cord-291950-9gtsqyfj	599	2	,	,	,
cord-291950-9gtsqyfj	599	3	characterization	characterization	NN
cord-291950-9gtsqyfj	599	4	,	,	,
cord-291950-9gtsqyfj	599	5	cloning	cloning	NN
cord-291950-9gtsqyfj	599	6	and	and	CC
cord-291950-9gtsqyfj	599	7	insights	insight	NNS
cord-291950-9gtsqyfj	599	8	into	into	IN
cord-291950-9gtsqyfj	599	9	its	-PRON-	PRP$
cord-291950-9gtsqyfj	599	10	mechanism	mechanism	NN
cord-291950-9gtsqyfj	599	11	of	of	IN
cord-291950-9gtsqyfj	599	12	action	action	NN
cord-291950-9gtsqyfj	599	13	Inhibition	Inhibition	NNP
cord-291950-9gtsqyfj	599	14	of	of	IN
cord-291950-9gtsqyfj	599	15	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	599	16	L	l	NN
cord-291950-9gtsqyfj	599	17	-	-	HYPH
cord-291950-9gtsqyfj	599	18	like	like	JJ
cord-291950-9gtsqyfj	599	19	cysteine	cysteine	NN
cord-291950-9gtsqyfj	599	20	proteases	protease	NNS
cord-291950-9gtsqyfj	599	21	by	by	IN
cord-291950-9gtsqyfj	599	22	cytotoxic	cytotoxic	JJ
cord-291950-9gtsqyfj	599	23	T	t	NN
cord-291950-9gtsqyfj	599	24	-	-	HYPH
cord-291950-9gtsqyfj	599	25	lymphocyte	lymphocyte	NN
cord-291950-9gtsqyfj	600	1	antigen-2	antigen-2	.
cord-291950-9gtsqyfj	600	2	beta	beta	NN
cord-291950-9gtsqyfj	601	1	A	a	DT
cord-291950-9gtsqyfj	601	2	primitive	primitive	JJ
cord-291950-9gtsqyfj	601	3	enzyme	enzyme	NN
cord-291950-9gtsqyfj	601	4	for	for	IN
cord-291950-9gtsqyfj	601	5	a	a	DT
cord-291950-9gtsqyfj	601	6	primitive	primitive	JJ
cord-291950-9gtsqyfj	601	7	cell	cell	NN
cord-291950-9gtsqyfj	602	1	:	:	:
cord-291950-9gtsqyfj	602	2	the	the	DT
cord-291950-9gtsqyfj	602	3	protease	protease	NN
cord-291950-9gtsqyfj	602	4	required	require	VBN
cord-291950-9gtsqyfj	602	5	for	for	IN
cord-291950-9gtsqyfj	602	6	excystation	excystation	NN
cord-291950-9gtsqyfj	602	7	of	of	IN
cord-291950-9gtsqyfj	602	8	Giardia	Giardia	NNP
cord-291950-9gtsqyfj	602	9	Molecular	Molecular	NNP
cord-291950-9gtsqyfj	602	10	cloning	cloning	NN
cord-291950-9gtsqyfj	602	11	,	,	,
cord-291950-9gtsqyfj	602	12	expression	expression	NN
cord-291950-9gtsqyfj	602	13	,	,	,
cord-291950-9gtsqyfj	602	14	and	and	CC
cord-291950-9gtsqyfj	602	15	chromosomal	chromosomal	JJ
cord-291950-9gtsqyfj	602	16	localization	localization	NN
cord-291950-9gtsqyfj	602	17	of	of	IN
cord-291950-9gtsqyfj	602	18	a	a	DT
cord-291950-9gtsqyfj	602	19	human	human	JJ
cord-291950-9gtsqyfj	602	20	tubulointerstitial	tubulointerstitial	JJ
cord-291950-9gtsqyfj	602	21	nephritis	nephritis	NN
cord-291950-9gtsqyfj	602	22	antigen	antigen	NNP
cord-291950-9gtsqyfj	602	23	Crystal	Crystal	NNP
cord-291950-9gtsqyfj	602	24	structure	structure	NN
cord-291950-9gtsqyfj	602	25	of	of	IN
cord-291950-9gtsqyfj	602	26	calpain	calpain	NN
cord-291950-9gtsqyfj	602	27	reveals	reveal	VBZ
cord-291950-9gtsqyfj	602	28	the	the	DT
cord-291950-9gtsqyfj	602	29	structural	structural	JJ
cord-291950-9gtsqyfj	602	30	basis	basis	NN
cord-291950-9gtsqyfj	602	31	for	for	IN
cord-291950-9gtsqyfj	602	32	Ca	Ca	NNP
cord-291950-9gtsqyfj	602	33	21	21	CD
cord-291950-9gtsqyfj	602	34	-dependent	-dependent	JJ
cord-291950-9gtsqyfj	602	35	protease	protease	NN
cord-291950-9gtsqyfj	602	36	activity	activity	NN
cord-291950-9gtsqyfj	602	37	and	and	CC
cord-291950-9gtsqyfj	602	38	a	a	DT
cord-291950-9gtsqyfj	602	39	novel	novel	JJ
cord-291950-9gtsqyfj	602	40	mode	mode	NN
cord-291950-9gtsqyfj	602	41	of	of	IN
cord-291950-9gtsqyfj	602	42	enzyme	enzyme	NN
cord-291950-9gtsqyfj	602	43	activation	activation	NN
cord-291950-9gtsqyfj	602	44	The	the	DT
cord-291950-9gtsqyfj	602	45	crystal	crystal	JJ
cord-291950-9gtsqyfj	602	46	structure	structure	NN
cord-291950-9gtsqyfj	602	47	of	of	IN
cord-291950-9gtsqyfj	602	48	calcium	calcium	NN
cord-291950-9gtsqyfj	602	49	-	-	HYPH
cord-291950-9gtsqyfj	602	50	free	free	JJ
cord-291950-9gtsqyfj	602	51	human	human	JJ
cord-291950-9gtsqyfj	602	52	m	m	NN
cord-291950-9gtsqyfj	602	53	-	-	HYPH
cord-291950-9gtsqyfj	602	54	calpain	calpain	NNP
cord-291950-9gtsqyfj	602	55	suggests	suggest	VBZ
cord-291950-9gtsqyfj	602	56	an	an	DT
cord-291950-9gtsqyfj	602	57	electrostatic	electrostatic	JJ
cord-291950-9gtsqyfj	602	58	switch	switch	NN
cord-291950-9gtsqyfj	602	59	mechanism	mechanism	NN
cord-291950-9gtsqyfj	602	60	for	for	IN
cord-291950-9gtsqyfj	602	61	activation	activation	NN
cord-291950-9gtsqyfj	602	62	by	by	IN
cord-291950-9gtsqyfj	602	63	calcium	calcium	NN
cord-291950-9gtsqyfj	602	64	CalpA	CalpA	NNP
cord-291950-9gtsqyfj	602	65	,	,	,
cord-291950-9gtsqyfj	602	66	a	a	DT
cord-291950-9gtsqyfj	602	67	Drosophila	Drosophila	NNP
cord-291950-9gtsqyfj	602	68	calpain	calpain	NN
cord-291950-9gtsqyfj	602	69	homolog	homolog	NN
cord-291950-9gtsqyfj	602	70	specifically	specifically	RB
cord-291950-9gtsqyfj	602	71	expressed	express	VBN
cord-291950-9gtsqyfj	602	72	in	in	IN
cord-291950-9gtsqyfj	602	73	a	a	DT
cord-291950-9gtsqyfj	602	74	small	small	JJ
cord-291950-9gtsqyfj	602	75	set	set	NN
cord-291950-9gtsqyfj	602	76	of	of	IN
cord-291950-9gtsqyfj	602	77	nerve	nerve	NN
cord-291950-9gtsqyfj	602	78	,	,	,
cord-291950-9gtsqyfj	602	79	midgut	midgut	NN
cord-291950-9gtsqyfj	602	80	,	,	,
cord-291950-9gtsqyfj	602	81	and	and	CC
cord-291950-9gtsqyfj	602	82	blood	blood	NN
cord-291950-9gtsqyfj	602	83	cells	cell	NNS
cord-291950-9gtsqyfj	603	1	Molecular	molecular	JJ
cord-291950-9gtsqyfj	603	2	cloning	cloning	NN
cord-291950-9gtsqyfj	603	3	and	and	CC
cord-291950-9gtsqyfj	603	4	analysis	analysis	NN
cord-291950-9gtsqyfj	603	5	of	of	IN
cord-291950-9gtsqyfj	603	6	small	small	JJ
cord-291950-9gtsqyfj	603	7	optic	optic	JJ
cord-291950-9gtsqyfj	603	8	lobes	lobe	NNS
cord-291950-9gtsqyfj	603	9	,	,	,
cord-291950-9gtsqyfj	603	10	a	a	DT
cord-291950-9gtsqyfj	603	11	structural	structural	JJ
cord-291950-9gtsqyfj	603	12	brain	brain	NN
cord-291950-9gtsqyfj	603	13	gene	gene	NN
cord-291950-9gtsqyfj	603	14	of	of	IN
cord-291950-9gtsqyfj	603	15	Drosophila	Drosophila	NNP
cord-291950-9gtsqyfj	603	16	melanogaster	melanogaster	NN
cord-291950-9gtsqyfj	603	17	On	on	IN
cord-291950-9gtsqyfj	603	18	the	the	DT
cord-291950-9gtsqyfj	603	19	mechanism	mechanism	NN
cord-291950-9gtsqyfj	603	20	of	of	IN
cord-291950-9gtsqyfj	603	21	action	action	NN
cord-291950-9gtsqyfj	603	22	of	of	IN
cord-291950-9gtsqyfj	603	23	streptococcal	streptococcal	JJ
cord-291950-9gtsqyfj	603	24	proteinase	proteinase	NN
cord-291950-9gtsqyfj	603	25	.	.	.
cord-291950-9gtsqyfj	604	1	II	II	NNP
cord-291950-9gtsqyfj	604	2	.	.	.
cord-291950-9gtsqyfj	605	1	Comparison	comparison	NN
cord-291950-9gtsqyfj	605	2	of	of	IN
cord-291950-9gtsqyfj	605	3	the	the	DT
cord-291950-9gtsqyfj	605	4	kinetics	kinetic	NNS
cord-291950-9gtsqyfj	605	5	of	of	IN
cord-291950-9gtsqyfj	605	6	proteinase	proteinase	NN
cord-291950-9gtsqyfj	605	7	-	-	HYPH
cord-291950-9gtsqyfj	605	8	and	and	CC
cord-291950-9gtsqyfj	605	9	papain	papain	NN
cord-291950-9gtsqyfj	605	10	-	-	HYPH
cord-291950-9gtsqyfj	605	11	catalyzed	catalyze	VBN
cord-291950-9gtsqyfj	605	12	hydrolysis	hydrolysis	NN
cord-291950-9gtsqyfj	605	13	of	of	IN
cord-291950-9gtsqyfj	605	14	N	n	CD
cord-291950-9gtsqyfj	605	15	-	-	HYPH
cord-291950-9gtsqyfj	605	16	acylamino	acylamino	NN
cord-291950-9gtsqyfj	605	17	acid	acid	NN
cord-291950-9gtsqyfj	605	18	esters	ester	NNS
cord-291950-9gtsqyfj	605	19	L	l	NN
cord-291950-9gtsqyfj	605	20	-	-	HYPH
cord-291950-9gtsqyfj	605	21	trans	trans	NNP
cord-291950-9gtsqyfj	605	22	-	-	NNP
cord-291950-9gtsqyfj	605	23	Epoxysuccinyl	Epoxysuccinyl	NNP
cord-291950-9gtsqyfj	605	24	-	-	HYPH
cord-291950-9gtsqyfj	605	25	leucylamido(4-guanidino)butane	leucylamido(4-guanidino)butane	NNP
cord-291950-9gtsqyfj	605	26	(	(	-LRB-
cord-291950-9gtsqyfj	605	27	E-64	E-64	NNP
cord-291950-9gtsqyfj	605	28	)	)	-RRB-
cord-291950-9gtsqyfj	605	29	and	and	CC
cord-291950-9gtsqyfj	605	30	its	-PRON-	PRP$
cord-291950-9gtsqyfj	605	31	analogues	analogue	NNS
cord-291950-9gtsqyfj	605	32	as	as	IN
cord-291950-9gtsqyfj	605	33	inhibitors	inhibitor	NNS
cord-291950-9gtsqyfj	605	34	of	of	IN
cord-291950-9gtsqyfj	605	35	cysteine	cysteine	NN
cord-291950-9gtsqyfj	605	36	proteinases	proteinase	NNS
cord-291950-9gtsqyfj	605	37	including	include	VBG
cord-291950-9gtsqyfj	605	38	cathepsins	cathepsin	NNS
cord-291950-9gtsqyfj	605	39	B	B	NNP
cord-291950-9gtsqyfj	605	40	,	,	,
cord-291950-9gtsqyfj	605	41	H	H	NNP
cord-291950-9gtsqyfj	605	42	and	and	CC
cord-291950-9gtsqyfj	605	43	L	L	NNP
cord-291950-9gtsqyfj	605	44	Crystal	Crystal	NNP
cord-291950-9gtsqyfj	605	45	structure	structure	NN
cord-291950-9gtsqyfj	605	46	of	of	IN
cord-291950-9gtsqyfj	605	47	a	a	DT
cord-291950-9gtsqyfj	605	48	deubiquitinating	deubiquitinating	NN
cord-291950-9gtsqyfj	605	49	enzyme	enzyme	NN
cord-291950-9gtsqyfj	605	50	(	(	-LRB-
cord-291950-9gtsqyfj	605	51	human	human	JJ
cord-291950-9gtsqyfj	605	52	UCH	UCH	NNP
cord-291950-9gtsqyfj	605	53	-	-	HYPH
cord-291950-9gtsqyfj	605	54	L3	L3	NNP
cord-291950-9gtsqyfj	605	55	)	)	-RRB-
cord-291950-9gtsqyfj	605	56	at	at	IN
cord-291950-9gtsqyfj	605	57	1.8Å	1.8Å	NNP
cord-291950-9gtsqyfj	605	58	resolution	resolution	NN
cord-291950-9gtsqyfj	605	59	Crystal	Crystal	NNP
cord-291950-9gtsqyfj	605	60	structure	structure	NN
cord-291950-9gtsqyfj	605	61	of	of	IN
cord-291950-9gtsqyfj	605	62	a	a	DT
cord-291950-9gtsqyfj	605	63	UBP	UBP	NNP
cord-291950-9gtsqyfj	605	64	-	-	HYPH
cord-291950-9gtsqyfj	605	65	family	family	NN
cord-291950-9gtsqyfj	605	66	deubiquitinating	deubiquitinating	NN
cord-291950-9gtsqyfj	605	67	enzyme	enzyme	NN
cord-291950-9gtsqyfj	605	68	in	in	IN
cord-291950-9gtsqyfj	605	69	isolation	isolation	NN
cord-291950-9gtsqyfj	605	70	and	and	CC
cord-291950-9gtsqyfj	605	71	in	in	IN
cord-291950-9gtsqyfj	605	72	complex	complex	NN
cord-291950-9gtsqyfj	605	73	with	with	IN
cord-291950-9gtsqyfj	605	74	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	605	75	aldehyde	aldehyde	NN
cord-291950-9gtsqyfj	605	76	Burkholderia	Burkholderia	NNP
cord-291950-9gtsqyfj	605	77	mallei	mallei	NNP
cord-291950-9gtsqyfj	605	78	tssM	tssm	PRP
cord-291950-9gtsqyfj	605	79	encodes	encode	VBZ
cord-291950-9gtsqyfj	605	80	a	a	DT
cord-291950-9gtsqyfj	605	81	putative	putative	JJ
cord-291950-9gtsqyfj	605	82	deubiquitinase	deubiquitinase	NN
cord-291950-9gtsqyfj	605	83	that	that	WDT
cord-291950-9gtsqyfj	605	84	is	be	VBZ
cord-291950-9gtsqyfj	605	85	secreted	secrete	VBN
cord-291950-9gtsqyfj	605	86	and	and	CC
cord-291950-9gtsqyfj	605	87	expressed	express	VBN
cord-291950-9gtsqyfj	605	88	inside	inside	IN
cord-291950-9gtsqyfj	605	89	infected	infect	VBN
cord-291950-9gtsqyfj	605	90	RAW	raw	JJ
cord-291950-9gtsqyfj	605	91	264.7	264.7	CD
cord-291950-9gtsqyfj	605	92	murine	murine	NN
cord-291950-9gtsqyfj	605	93	macrophages	macrophage	NNS
cord-291950-9gtsqyfj	605	94	A	a	DT
cord-291950-9gtsqyfj	605	95	novel	novel	JJ
cord-291950-9gtsqyfj	605	96	superfamily	superfamily	NN
cord-291950-9gtsqyfj	605	97	of	of	IN
cord-291950-9gtsqyfj	605	98	predicted	predict	VBN
cord-291950-9gtsqyfj	605	99	cysteine	cysteine	NN
cord-291950-9gtsqyfj	605	100	proteases	protease	NNS
cord-291950-9gtsqyfj	605	101	from	from	IN
cord-291950-9gtsqyfj	605	102	eukaryotes	eukaryote	NNS
cord-291950-9gtsqyfj	605	103	,	,	,
cord-291950-9gtsqyfj	605	104	viruses	virus	NNS
cord-291950-9gtsqyfj	605	105	and	and	CC
cord-291950-9gtsqyfj	605	106	Chlamydia	Chlamydia	NNP
cord-291950-9gtsqyfj	605	107	pneumoniae	pneumoniae	NN
cord-291950-9gtsqyfj	606	1	A	a	DT
cord-291950-9gtsqyfj	606	2	novel	novel	JJ
cord-291950-9gtsqyfj	606	3	type	type	NN
cord-291950-9gtsqyfj	606	4	of	of	IN
cord-291950-9gtsqyfj	606	5	deubiquitinating	deubiquitinating	NN
cord-291950-9gtsqyfj	606	6	enzyme	enzyme	NN
cord-291950-9gtsqyfj	606	7	Structure	Structure	NNP
cord-291950-9gtsqyfj	606	8	of	of	IN
cord-291950-9gtsqyfj	606	9	the	the	DT
cord-291950-9gtsqyfj	606	10	A20	A20	NNP
cord-291950-9gtsqyfj	606	11	OTU	OTU	NNP
cord-291950-9gtsqyfj	606	12	domain	domain	NN
cord-291950-9gtsqyfj	606	13	and	and	CC
cord-291950-9gtsqyfj	606	14	mechanistic	mechanistic	JJ
cord-291950-9gtsqyfj	606	15	insights	insight	NNS
cord-291950-9gtsqyfj	606	16	into	into	IN
cord-291950-9gtsqyfj	606	17	deubiquitination	deubiquitination	NNP
cord-291950-9gtsqyfj	606	18	Crystal	Crystal	NNP
cord-291950-9gtsqyfj	606	19	structure	structure	NN
cord-291950-9gtsqyfj	606	20	of	of	IN
cord-291950-9gtsqyfj	606	21	human	human	JJ
cord-291950-9gtsqyfj	606	22	otubain	otubain	NN
cord-291950-9gtsqyfj	606	23	2	2	CD
cord-291950-9gtsqyfj	606	24	Evidence	evidence	NN
cord-291950-9gtsqyfj	606	25	for	for	IN
cord-291950-9gtsqyfj	606	26	bidentate	bidentate	JJ
cord-291950-9gtsqyfj	606	27	substrate	substrate	NN
cord-291950-9gtsqyfj	606	28	binding	bind	VBG
cord-291950-9gtsqyfj	606	29	as	as	IN
cord-291950-9gtsqyfj	606	30	the	the	DT
cord-291950-9gtsqyfj	606	31	basis	basis	NN
cord-291950-9gtsqyfj	606	32	for	for	IN
cord-291950-9gtsqyfj	606	33	the	the	DT
cord-291950-9gtsqyfj	606	34	K48	K48	NNP
cord-291950-9gtsqyfj	606	35	linkage	linkage	NN
cord-291950-9gtsqyfj	606	36	specificity	specificity	NN
cord-291950-9gtsqyfj	606	37	of	of	IN
cord-291950-9gtsqyfj	606	38	otubain	otubain	NN
cord-291950-9gtsqyfj	606	39	1	1	CD
cord-291950-9gtsqyfj	607	1	The	the	DT
cord-291950-9gtsqyfj	607	2	tumour	tumour	NN
cord-291950-9gtsqyfj	607	3	suppressor	suppressor	NN
cord-291950-9gtsqyfj	607	4	CYLD	CYLD	NNP
cord-291950-9gtsqyfj	607	5	negatively	negatively	RB
cord-291950-9gtsqyfj	607	6	regulates	regulate	VBZ
cord-291950-9gtsqyfj	607	7	NF	NF	NNP
cord-291950-9gtsqyfj	607	8	-	-	HYPH
cord-291950-9gtsqyfj	607	9	kappaB	kappaB	NNP
cord-291950-9gtsqyfj	607	10	signalling	signal	VBG
cord-291950-9gtsqyfj	607	11	by	by	IN
cord-291950-9gtsqyfj	607	12	deubiquitination	deubiquitination	NN
cord-291950-9gtsqyfj	608	1	The	the	DT
cord-291950-9gtsqyfj	608	2	structure	structure	NN
cord-291950-9gtsqyfj	608	3	of	of	IN
cord-291950-9gtsqyfj	608	4	the	the	DT
cord-291950-9gtsqyfj	608	5	CYLD	CYLD	NNP
cord-291950-9gtsqyfj	608	6	USP	USP	NNP
cord-291950-9gtsqyfj	608	7	domain	domain	NN
cord-291950-9gtsqyfj	608	8	explains	explain	VBZ
cord-291950-9gtsqyfj	608	9	its	-PRON-	PRP$
cord-291950-9gtsqyfj	608	10	specificity	specificity	NN
cord-291950-9gtsqyfj	608	11	for	for	IN
cord-291950-9gtsqyfj	608	12	Lys63-linked	Lys63-linked	NNP
cord-291950-9gtsqyfj	608	13	polyubiquitin	polyubiquitin	NNS
cord-291950-9gtsqyfj	608	14	and	and	CC
cord-291950-9gtsqyfj	608	15	reveals	reveal	VBZ
cord-291950-9gtsqyfj	608	16	a	a	DT
cord-291950-9gtsqyfj	608	17	B	B	NNP
cord-291950-9gtsqyfj	608	18	Box	Box	NNP
cord-291950-9gtsqyfj	608	19	module	module	NN
cord-291950-9gtsqyfj	608	20	DUBA	DUBA	NNP
cord-291950-9gtsqyfj	608	21	:	:	:
cord-291950-9gtsqyfj	608	22	a	a	DT
cord-291950-9gtsqyfj	608	23	deubiquitinase	deubiquitinase	NN
cord-291950-9gtsqyfj	608	24	that	that	WDT
cord-291950-9gtsqyfj	608	25	regulates	regulate	VBZ
cord-291950-9gtsqyfj	608	26	type	type	NN
cord-291950-9gtsqyfj	609	1	I	-PRON-	PRP
cord-291950-9gtsqyfj	609	2	interferon	interferon	VBD
cord-291950-9gtsqyfj	609	3	production	production	NN
cord-291950-9gtsqyfj	610	1	The	the	DT
cord-291950-9gtsqyfj	610	2	solution	solution	NN
cord-291950-9gtsqyfj	610	3	structure	structure	NN
cord-291950-9gtsqyfj	610	4	of	of	IN
cord-291950-9gtsqyfj	610	5	the	the	DT
cord-291950-9gtsqyfj	610	6	Josephin	Josephin	NNP
cord-291950-9gtsqyfj	610	7	domain	domain	NN
cord-291950-9gtsqyfj	610	8	of	of	IN
cord-291950-9gtsqyfj	610	9	ataxin-3	ataxin-3	NN
cord-291950-9gtsqyfj	610	10	:	:	:
cord-291950-9gtsqyfj	610	11	structural	structural	JJ
cord-291950-9gtsqyfj	610	12	determinants	determinant	NNS
cord-291950-9gtsqyfj	610	13	for	for	IN
cord-291950-9gtsqyfj	610	14	molecular	molecular	JJ
cord-291950-9gtsqyfj	610	15	recognition	recognition	NN
cord-291950-9gtsqyfj	610	16	Structural	structural	JJ
cord-291950-9gtsqyfj	610	17	basis	basis	NN
cord-291950-9gtsqyfj	610	18	for	for	IN
cord-291950-9gtsqyfj	610	19	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	610	20	recognition	recognition	NN
cord-291950-9gtsqyfj	610	21	by	by	IN
cord-291950-9gtsqyfj	610	22	the	the	DT
cord-291950-9gtsqyfj	610	23	OTU1	OTU1	NNP
cord-291950-9gtsqyfj	610	24	ovarian	ovarian	JJ
cord-291950-9gtsqyfj	610	25	tumor	tumor	NN
cord-291950-9gtsqyfj	610	26	domain	domain	NN
cord-291950-9gtsqyfj	610	27	protein	protein	NN
cord-291950-9gtsqyfj	610	28	Structure	Structure	NNP
cord-291950-9gtsqyfj	610	29	of	of	IN
cord-291950-9gtsqyfj	610	30	a	a	DT
cord-291950-9gtsqyfj	610	31	herpesvirusencoded	herpesvirusencode	VBN
cord-291950-9gtsqyfj	610	32	cysteine	cysteine	NN
cord-291950-9gtsqyfj	610	33	protease	protease	NN
cord-291950-9gtsqyfj	610	34	reveals	reveal	VBZ
cord-291950-9gtsqyfj	610	35	a	a	DT
cord-291950-9gtsqyfj	610	36	unique	unique	JJ
cord-291950-9gtsqyfj	610	37	class	class	NN
cord-291950-9gtsqyfj	610	38	of	of	IN
cord-291950-9gtsqyfj	610	39	deubiquitinating	deubiquitinating	NN
cord-291950-9gtsqyfj	610	40	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	610	41	Ovarian	ovarian	JJ
cord-291950-9gtsqyfj	610	42	tumor	tumor	NN
cord-291950-9gtsqyfj	610	43	domain	domain	NN
cord-291950-9gtsqyfj	610	44	-	-	HYPH
cord-291950-9gtsqyfj	610	45	containing	contain	VBG
cord-291950-9gtsqyfj	610	46	viral	viral	JJ
cord-291950-9gtsqyfj	610	47	proteases	protease	NNS
cord-291950-9gtsqyfj	610	48	evade	evade	VBP
cord-291950-9gtsqyfj	610	49	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	610	50	-	-	:
cord-291950-9gtsqyfj	610	51	and	and	CC
cord-291950-9gtsqyfj	610	52	ISG15-dependent	isg15-dependent	CD
cord-291950-9gtsqyfj	610	53	innate	innate	JJ
cord-291950-9gtsqyfj	610	54	immune	immune	JJ
cord-291950-9gtsqyfj	610	55	responses	response	NNS
cord-291950-9gtsqyfj	610	56	Two	two	CD
cord-291950-9gtsqyfj	610	57	novel	novel	NN
cord-291950-9gtsqyfj	610	58	ubiquitin	ubiquitin	NN
cord-291950-9gtsqyfj	610	59	-	-	HYPH
cord-291950-9gtsqyfj	610	60	fold	fold	JJ
cord-291950-9gtsqyfj	610	61	modifier	modifier	NN
cord-291950-9gtsqyfj	610	62	1	1	CD
cord-291950-9gtsqyfj	611	1	(	(	-LRB-
cord-291950-9gtsqyfj	611	2	Ufm1)-specific	ufm1)-specific	IN
cord-291950-9gtsqyfj	611	3	proteases	protease	NNS
cord-291950-9gtsqyfj	611	4	,	,	,
cord-291950-9gtsqyfj	611	5	UfSP1	UfSP1	NNP
cord-291950-9gtsqyfj	611	6	and	and	CC
cord-291950-9gtsqyfj	611	7	UfSP2	UfSP2	NNP
cord-291950-9gtsqyfj	611	8	Structural	structural	JJ
cord-291950-9gtsqyfj	611	9	basis	basis	NN
cord-291950-9gtsqyfj	611	10	for	for	IN
cord-291950-9gtsqyfj	611	11	Ufm1	ufm1	JJ
cord-291950-9gtsqyfj	611	12	processing	processing	NN
cord-291950-9gtsqyfj	611	13	by	by	IN
cord-291950-9gtsqyfj	611	14	UfSP1	UfSP1	NNP
cord-291950-9gtsqyfj	612	1	The	the	DT
cord-291950-9gtsqyfj	612	2	crystal	crystal	JJ
cord-291950-9gtsqyfj	612	3	structure	structure	NN
cord-291950-9gtsqyfj	612	4	of	of	IN
cord-291950-9gtsqyfj	612	5	human	human	NN
cord-291950-9gtsqyfj	612	6	Atg4b	Atg4b	NNP
cord-291950-9gtsqyfj	612	7	,	,	,
cord-291950-9gtsqyfj	612	8	a	a	DT
cord-291950-9gtsqyfj	612	9	processing	processing	NN
cord-291950-9gtsqyfj	612	10	and	and	CC
cord-291950-9gtsqyfj	612	11	de	de	JJ
cord-291950-9gtsqyfj	612	12	-	-	JJ
cord-291950-9gtsqyfj	612	13	conjugating	conjugate	VBG
cord-291950-9gtsqyfj	612	14	enzyme	enzyme	NN
cord-291950-9gtsqyfj	612	15	for	for	IN
cord-291950-9gtsqyfj	612	16	autophagosome	autophagosome	NN
cord-291950-9gtsqyfj	612	17	-	-	HYPH
cord-291950-9gtsqyfj	612	18	forming	form	VBG
cord-291950-9gtsqyfj	612	19	modifiers	modifier	NNS
cord-291950-9gtsqyfj	612	20	Structural	structural	JJ
cord-291950-9gtsqyfj	612	21	basis	basis	NN
cord-291950-9gtsqyfj	612	22	for	for	IN
cord-291950-9gtsqyfj	612	23	the	the	DT
cord-291950-9gtsqyfj	612	24	specificity	specificity	NN
cord-291950-9gtsqyfj	612	25	and	and	CC
cord-291950-9gtsqyfj	612	26	catalysis	catalysis	NN
cord-291950-9gtsqyfj	612	27	of	of	IN
cord-291950-9gtsqyfj	612	28	human	human	NN
cord-291950-9gtsqyfj	612	29	Atg4B	Atg4B	.
cord-291950-9gtsqyfj	612	30	responsible	responsible	JJ
cord-291950-9gtsqyfj	612	31	for	for	IN
cord-291950-9gtsqyfj	612	32	mammalian	mammalian	JJ
cord-291950-9gtsqyfj	612	33	autophagy	autophagy	NN
cord-291950-9gtsqyfj	612	34	Crystal	Crystal	NNP
cord-291950-9gtsqyfj	612	35	structure	structure	NN
cord-291950-9gtsqyfj	612	36	of	of	IN
cord-291950-9gtsqyfj	612	37	a	a	DT
cord-291950-9gtsqyfj	612	38	thiol	thiol	NN
cord-291950-9gtsqyfj	612	39	proteinase	proteinase	NN
cord-291950-9gtsqyfj	612	40	from	from	IN
cord-291950-9gtsqyfj	612	41	Staphylococcus	Staphylococcus	NNP
cord-291950-9gtsqyfj	612	42	aureus	aureus	NN
cord-291950-9gtsqyfj	612	43	V8	V8	NNP
cord-291950-9gtsqyfj	612	44	in	in	IN
cord-291950-9gtsqyfj	612	45	the	the	DT
cord-291950-9gtsqyfj	612	46	E-64	E-64	NNP
cord-291950-9gtsqyfj	612	47	inhibitor	inhibitor	NN
cord-291950-9gtsqyfj	612	48	complex	complex	NN
cord-291950-9gtsqyfj	612	49	Crystal	Crystal	NNP
cord-291950-9gtsqyfj	612	50	structure	structure	NN
cord-291950-9gtsqyfj	612	51	of	of	IN
cord-291950-9gtsqyfj	612	52	the	the	DT
cord-291950-9gtsqyfj	612	53	peptidase	peptidase	NN
cord-291950-9gtsqyfj	612	54	domain	domain	NN
cord-291950-9gtsqyfj	612	55	of	of	IN
cord-291950-9gtsqyfj	612	56	streptococcus	streptococcus	NN
cord-291950-9gtsqyfj	612	57	ComA	ComA	NNP
cord-291950-9gtsqyfj	612	58	,	,	,
cord-291950-9gtsqyfj	612	59	a	a	DT
cord-291950-9gtsqyfj	612	60	bifunctional	bifunctional	JJ
cord-291950-9gtsqyfj	612	61	ATP	ATP	NNP
cord-291950-9gtsqyfj	612	62	-	-	HYPH
cord-291950-9gtsqyfj	612	63	binding	bind	VBG
cord-291950-9gtsqyfj	612	64	cassette	cassette	NN
cord-291950-9gtsqyfj	612	65	transporter	transporter	NN
cord-291950-9gtsqyfj	612	66	involved	involve	VBN
cord-291950-9gtsqyfj	612	67	in	in	IN
cord-291950-9gtsqyfj	612	68	the	the	DT
cord-291950-9gtsqyfj	612	69	quorum	quorum	NN
cord-291950-9gtsqyfj	612	70	-	-	HYPH
cord-291950-9gtsqyfj	612	71	sensing	sense	VBG
cord-291950-9gtsqyfj	612	72	pathway	pathway	NN
cord-291950-9gtsqyfj	612	73	Multiple	multiple	JJ
cord-291950-9gtsqyfj	612	74	enzymatic	enzymatic	JJ
cord-291950-9gtsqyfj	612	75	activities	activity	NNS
cord-291950-9gtsqyfj	612	76	of	of	IN
cord-291950-9gtsqyfj	612	77	the	the	DT
cord-291950-9gtsqyfj	612	78	murein	murein	NNP
cord-291950-9gtsqyfj	612	79	hydrolase	hydrolase	NN
cord-291950-9gtsqyfj	612	80	from	from	IN
cord-291950-9gtsqyfj	612	81	staphylococcal	staphylococcal	JJ
cord-291950-9gtsqyfj	612	82	phage	phage	NN
cord-291950-9gtsqyfj	612	83	phi11	phi11	NNS
cord-291950-9gtsqyfj	612	84	.	.	.
cord-291950-9gtsqyfj	613	1	Identification	identification	NN
cord-291950-9gtsqyfj	613	2	of	of	IN
cord-291950-9gtsqyfj	613	3	a	a	DT
cord-291950-9gtsqyfj	613	4	D	d	NN
cord-291950-9gtsqyfj	613	5	-	-	HYPH
cord-291950-9gtsqyfj	613	6	alanyl	alanyl	JJ
cord-291950-9gtsqyfj	613	7	-	-	HYPH
cord-291950-9gtsqyfj	613	8	glycine	glycine	NN
cord-291950-9gtsqyfj	613	9	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	613	10	activity	activity	NN
cord-291950-9gtsqyfj	613	11	Cysteine	Cysteine	NNP
cord-291950-9gtsqyfj	613	12	proteases	protease	NNS
cord-291950-9gtsqyfj	613	13	in	in	IN
cord-291950-9gtsqyfj	613	14	phytopathogenic	phytopathogenic	JJ
cord-291950-9gtsqyfj	613	15	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	613	16	:	:	:
cord-291950-9gtsqyfj	613	17	identification	identification	NN
cord-291950-9gtsqyfj	613	18	of	of	IN
cord-291950-9gtsqyfj	613	19	plant	plant	NN
cord-291950-9gtsqyfj	613	20	targets	target	NNS
cord-291950-9gtsqyfj	613	21	and	and	CC
cord-291950-9gtsqyfj	613	22	activation	activation	NN
cord-291950-9gtsqyfj	613	23	of	of	IN
cord-291950-9gtsqyfj	613	24	innate	innate	JJ
cord-291950-9gtsqyfj	613	25	immunity	immunity	NN
cord-291950-9gtsqyfj	613	26	Initiation	Initiation	NNP
cord-291950-9gtsqyfj	613	27	of	of	IN
cord-291950-9gtsqyfj	613	28	RPS2-specified	RPS2-specified	NNP
cord-291950-9gtsqyfj	613	29	disease	disease	NN
cord-291950-9gtsqyfj	613	30	resistance	resistance	NN
cord-291950-9gtsqyfj	613	31	in	in	IN
cord-291950-9gtsqyfj	613	32	Arabidopsis	Arabidopsis	NNP
cord-291950-9gtsqyfj	613	33	is	be	VBZ
cord-291950-9gtsqyfj	613	34	coupled	couple	VBN
cord-291950-9gtsqyfj	613	35	to	to	IN
cord-291950-9gtsqyfj	613	36	the	the	DT
cord-291950-9gtsqyfj	613	37	AvrRpt2-directed	avrrpt2-directe	VBN
cord-291950-9gtsqyfj	613	38	elimination	elimination	NN
cord-291950-9gtsqyfj	613	39	of	of	IN
cord-291950-9gtsqyfj	613	40	RIN4	RIN4	NNP
cord-291950-9gtsqyfj	613	41	A	A	NNP
cord-291950-9gtsqyfj	613	42	Yersinia	Yersinia	NNP
cord-291950-9gtsqyfj	613	43	effector	effector	NN
cord-291950-9gtsqyfj	613	44	and	and	CC
cord-291950-9gtsqyfj	613	45	a	a	DT
cord-291950-9gtsqyfj	613	46	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	613	47	avirulence	avirulence	NN
cord-291950-9gtsqyfj	613	48	protein	protein	NN
cord-291950-9gtsqyfj	613	49	define	define	VBP
cord-291950-9gtsqyfj	613	50	a	a	DT
cord-291950-9gtsqyfj	613	51	family	family	NN
cord-291950-9gtsqyfj	613	52	of	of	IN
cord-291950-9gtsqyfj	613	53	cysteine	cysteine	NN
cord-291950-9gtsqyfj	613	54	proteases	protease	NNS
cord-291950-9gtsqyfj	613	55	functioning	function	VBG
cord-291950-9gtsqyfj	613	56	in	in	IN
cord-291950-9gtsqyfj	613	57	bacterial	bacterial	JJ
cord-291950-9gtsqyfj	613	58	pathogenesis	pathogenesis	NN
cord-291950-9gtsqyfj	613	59	HopPtoN	hoppton	NN
cord-291950-9gtsqyfj	614	1	is	be	VBZ
cord-291950-9gtsqyfj	614	2	a	a	DT
cord-291950-9gtsqyfj	614	3	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	614	4	syringae	syringae	NN
cord-291950-9gtsqyfj	614	5	Hrp	Hrp	NNP
cord-291950-9gtsqyfj	614	6	(	(	-LRB-
cord-291950-9gtsqyfj	614	7	type	type	NN
cord-291950-9gtsqyfj	614	8	III	iii	CD
cord-291950-9gtsqyfj	614	9	secretion	secretion	NN
cord-291950-9gtsqyfj	614	10	system	system	NN
cord-291950-9gtsqyfj	614	11	)	)	-RRB-
cord-291950-9gtsqyfj	615	1	cysteine	cysteine	NN
cord-291950-9gtsqyfj	615	2	protease	protease	NN
cord-291950-9gtsqyfj	615	3	effector	effector	NN
cord-291950-9gtsqyfj	615	4	that	that	WDT
cord-291950-9gtsqyfj	615	5	suppresses	suppress	VBZ
cord-291950-9gtsqyfj	615	6	pathogeninduced	pathogeninduced	JJ
cord-291950-9gtsqyfj	615	7	necrosis	necrosis	NN
cord-291950-9gtsqyfj	615	8	associated	associate	VBN
cord-291950-9gtsqyfj	615	9	with	with	IN
cord-291950-9gtsqyfj	615	10	both	both	CC
cord-291950-9gtsqyfj	615	11	compatible	compatible	JJ
cord-291950-9gtsqyfj	615	12	and	and	CC
cord-291950-9gtsqyfj	615	13	incompatible	incompatible	JJ
cord-291950-9gtsqyfj	615	14	plant	plant	NN
cord-291950-9gtsqyfj	615	15	interactions	interaction	NNS
cord-291950-9gtsqyfj	615	16	Structure	Structure	NNP
cord-291950-9gtsqyfj	615	17	of	of	IN
cord-291950-9gtsqyfj	615	18	the	the	DT
cord-291950-9gtsqyfj	615	19	streptococcal	streptococcal	JJ
cord-291950-9gtsqyfj	615	20	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	615	21	IdeS	IdeS	NNP
cord-291950-9gtsqyfj	615	22	,	,	,
cord-291950-9gtsqyfj	615	23	a	a	DT
cord-291950-9gtsqyfj	615	24	cysteine	cysteine	NN
cord-291950-9gtsqyfj	615	25	proteinase	proteinase	NN
cord-291950-9gtsqyfj	615	26	with	with	IN
cord-291950-9gtsqyfj	615	27	strict	strict	JJ
cord-291950-9gtsqyfj	615	28	specificity	specificity	NN
cord-291950-9gtsqyfj	615	29	for	for	IN
cord-291950-9gtsqyfj	615	30	IgG	IgG	NNP
cord-291950-9gtsqyfj	615	31	A	a	DT
cord-291950-9gtsqyfj	615	32	papain	papain	NN
cord-291950-9gtsqyfj	615	33	-	-	HYPH
cord-291950-9gtsqyfj	615	34	like	like	JJ
cord-291950-9gtsqyfj	615	35	enzyme	enzyme	NN
cord-291950-9gtsqyfj	615	36	at	at	IN
cord-291950-9gtsqyfj	615	37	work	work	NN
cord-291950-9gtsqyfj	615	38	:	:	:
cord-291950-9gtsqyfj	616	1	native	native	JJ
cord-291950-9gtsqyfj	616	2	and	and	CC
cord-291950-9gtsqyfj	616	3	acyl	acyl	NN
cord-291950-9gtsqyfj	616	4	-	-	HYPH
cord-291950-9gtsqyfj	616	5	enzyme	enzyme	NN
cord-291950-9gtsqyfj	616	6	intermediate	intermediate	JJ
cord-291950-9gtsqyfj	616	7	structures	structure	NNS
cord-291950-9gtsqyfj	616	8	in	in	IN
cord-291950-9gtsqyfj	616	9	phytochelatin	phytochelatin	NNP
cord-291950-9gtsqyfj	616	10	synthesis	synthesis	NN
cord-291950-9gtsqyfj	616	11	Identification	identification	NN
cord-291950-9gtsqyfj	616	12	of	of	IN
cord-291950-9gtsqyfj	616	13	the	the	DT
cord-291950-9gtsqyfj	616	14	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	616	15	sites	site	NNS
cord-291950-9gtsqyfj	616	16	of	of	IN
cord-291950-9gtsqyfj	616	17	a	a	DT
cord-291950-9gtsqyfj	616	18	papain	papain	NN
cord-291950-9gtsqyfj	616	19	-	-	HYPH
cord-291950-9gtsqyfj	616	20	like	like	JJ
cord-291950-9gtsqyfj	616	21	cysteine	cysteine	NN
cord-291950-9gtsqyfj	616	22	proteinase	proteinase	NN
cord-291950-9gtsqyfj	616	23	of	of	IN
cord-291950-9gtsqyfj	616	24	murine	murine	JJ
cord-291950-9gtsqyfj	616	25	coronavirus	coronavirus	NN
cord-291950-9gtsqyfj	616	26	Coronavirus	Coronavirus	NNP
cord-291950-9gtsqyfj	616	27	protein	protein	NN
cord-291950-9gtsqyfj	616	28	processing	processing	NN
cord-291950-9gtsqyfj	616	29	and	and	CC
cord-291950-9gtsqyfj	616	30	RNA	RNA	NNP
cord-291950-9gtsqyfj	616	31	synthesis	synthesis	NN
cord-291950-9gtsqyfj	616	32	is	be	VBZ
cord-291950-9gtsqyfj	616	33	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	616	34	by	by	IN
cord-291950-9gtsqyfj	616	35	the	the	DT
cord-291950-9gtsqyfj	616	36	cysteine	cysteine	NN
cord-291950-9gtsqyfj	616	37	proteinase	proteinase	NN
cord-291950-9gtsqyfj	616	38	inhibitor	inhibitor	NN
cord-291950-9gtsqyfj	616	39	E64d	e64d	NN
cord-291950-9gtsqyfj	616	40	Processing	processing	NN
cord-291950-9gtsqyfj	616	41	and	and	CC
cord-291950-9gtsqyfj	616	42	evolution	evolution	NN
cord-291950-9gtsqyfj	616	43	of	of	IN
cord-291950-9gtsqyfj	616	44	the	the	DT
cord-291950-9gtsqyfj	616	45	N	n	CD
cord-291950-9gtsqyfj	616	46	-	-	HYPH
cord-291950-9gtsqyfj	616	47	terminal	terminal	JJ
cord-291950-9gtsqyfj	616	48	region	region	NN
cord-291950-9gtsqyfj	616	49	of	of	IN
cord-291950-9gtsqyfj	616	50	the	the	DT
cord-291950-9gtsqyfj	616	51	arterivirus	arterivirus	NNP
cord-291950-9gtsqyfj	616	52	replicase	replicase	NNP
cord-291950-9gtsqyfj	616	53	ORF1a	ORF1a	NNP
cord-291950-9gtsqyfj	616	54	protein	protein	NN
cord-291950-9gtsqyfj	616	55	:	:	:
cord-291950-9gtsqyfj	616	56	identification	identification	NN
cord-291950-9gtsqyfj	616	57	of	of	IN
cord-291950-9gtsqyfj	616	58	two	two	CD
cord-291950-9gtsqyfj	616	59	papain	papain	NN
cord-291950-9gtsqyfj	616	60	-	-	HYPH
cord-291950-9gtsqyfj	616	61	like	like	JJ
cord-291950-9gtsqyfj	616	62	cysteine	cysteine	NN
cord-291950-9gtsqyfj	616	63	proteases	protease	NNS
cord-291950-9gtsqyfj	616	64	The	the	DT
cord-291950-9gtsqyfj	616	65	arterivirus	arterivirus	NN
cord-291950-9gtsqyfj	616	66	Nsp2	Nsp2	NNP
cord-291950-9gtsqyfj	616	67	protease	protease	NN
cord-291950-9gtsqyfj	616	68	.	.	.
cord-291950-9gtsqyfj	617	1	An	an	DT
cord-291950-9gtsqyfj	617	2	unusual	unusual	JJ
cord-291950-9gtsqyfj	617	3	cysteine	cysteine	NN
cord-291950-9gtsqyfj	617	4	protease	protease	NN
cord-291950-9gtsqyfj	617	5	with	with	IN
cord-291950-9gtsqyfj	617	6	primary	primary	JJ
cord-291950-9gtsqyfj	617	7	structure	structure	NN
cord-291950-9gtsqyfj	617	8	similarities	similarity	NNS
cord-291950-9gtsqyfj	617	9	to	to	IN
cord-291950-9gtsqyfj	617	10	both	both	CC
cord-291950-9gtsqyfj	617	11	papain	papain	NN
cord-291950-9gtsqyfj	617	12	-	-	HYPH
cord-291950-9gtsqyfj	617	13	like	like	JJ
cord-291950-9gtsqyfj	617	14	and	and	CC
cord-291950-9gtsqyfj	617	15	chymotrypsin	chymotrypsin	JJ
cord-291950-9gtsqyfj	617	16	-	-	HYPH
cord-291950-9gtsqyfj	617	17	like	like	JJ
cord-291950-9gtsqyfj	617	18	proteases	protease	NNS
cord-291950-9gtsqyfj	618	1	Pseudomurein	Pseudomurein	NNP
cord-291950-9gtsqyfj	618	2	endoisopeptidases	endoisopeptidase	VBZ
cord-291950-9gtsqyfj	618	3	PeiW	PeiW	NNP
cord-291950-9gtsqyfj	618	4	and	and	CC
cord-291950-9gtsqyfj	618	5	PeiP	PeiP	NNP
cord-291950-9gtsqyfj	618	6	,	,	,
cord-291950-9gtsqyfj	618	7	two	two	CD
cord-291950-9gtsqyfj	618	8	moderately	moderately	RB
cord-291950-9gtsqyfj	618	9	related	related	JJ
cord-291950-9gtsqyfj	618	10	members	member	NNS
cord-291950-9gtsqyfj	618	11	of	of	IN
cord-291950-9gtsqyfj	618	12	a	a	DT
cord-291950-9gtsqyfj	618	13	novel	novel	JJ
cord-291950-9gtsqyfj	618	14	family	family	NN
cord-291950-9gtsqyfj	618	15	of	of	IN
cord-291950-9gtsqyfj	618	16	proteases	protease	NNS
cord-291950-9gtsqyfj	618	17	produced	produce	VBN
cord-291950-9gtsqyfj	618	18	in	in	IN
cord-291950-9gtsqyfj	618	19	Methanothermobacter	Methanothermobacter	NNP
cord-291950-9gtsqyfj	618	20	strains	strain	VBZ
cord-291950-9gtsqyfj	618	21	Viral	viral	JJ
cord-291950-9gtsqyfj	618	22	cysteine	cysteine	NN
cord-291950-9gtsqyfj	618	23	proteases	protease	NNS
cord-291950-9gtsqyfj	618	24	are	be	VBP
cord-291950-9gtsqyfj	618	25	homologous	homologous	JJ
cord-291950-9gtsqyfj	618	26	to	to	IN
cord-291950-9gtsqyfj	618	27	the	the	DT
cord-291950-9gtsqyfj	618	28	trypsin	trypsin	NN
cord-291950-9gtsqyfj	618	29	-	-	HYPH
cord-291950-9gtsqyfj	618	30	like	like	JJ
cord-291950-9gtsqyfj	618	31	family	family	NN
cord-291950-9gtsqyfj	618	32	of	of	IN
cord-291950-9gtsqyfj	618	33	serine	serine	NN
cord-291950-9gtsqyfj	618	34	proteases	protease	NNS
cord-291950-9gtsqyfj	618	35	:	:	:
cord-291950-9gtsqyfj	618	36	structural	structural	JJ
cord-291950-9gtsqyfj	618	37	and	and	CC
cord-291950-9gtsqyfj	618	38	functional	functional	JJ
cord-291950-9gtsqyfj	618	39	implications	implication	NNS
cord-291950-9gtsqyfj	619	1	The	the	DT
cord-291950-9gtsqyfj	619	2	structure	structure	NN
cord-291950-9gtsqyfj	619	3	of	of	IN
cord-291950-9gtsqyfj	619	4	the	the	DT
cord-291950-9gtsqyfj	619	5	2A	2a	CD
cord-291950-9gtsqyfj	619	6	proteinase	proteinase	NN
cord-291950-9gtsqyfj	619	7	from	from	IN
cord-291950-9gtsqyfj	619	8	a	a	DT
cord-291950-9gtsqyfj	619	9	common	common	JJ
cord-291950-9gtsqyfj	619	10	cold	cold	JJ
cord-291950-9gtsqyfj	619	11	virus	virus	NN
cord-291950-9gtsqyfj	619	12	:	:	:
cord-291950-9gtsqyfj	619	13	a	a	DT
cord-291950-9gtsqyfj	619	14	proteinase	proteinase	NN
cord-291950-9gtsqyfj	619	15	responsible	responsible	JJ
cord-291950-9gtsqyfj	619	16	for	for	IN
cord-291950-9gtsqyfj	619	17	the	the	DT
cord-291950-9gtsqyfj	619	18	shut	shut	NN
cord-291950-9gtsqyfj	619	19	-	-	HYPH
cord-291950-9gtsqyfj	619	20	off	off	NN
cord-291950-9gtsqyfj	619	21	of	of	IN
cord-291950-9gtsqyfj	619	22	host	host	NN
cord-291950-9gtsqyfj	619	23	-	-	HYPH
cord-291950-9gtsqyfj	619	24	cell	cell	NN
cord-291950-9gtsqyfj	619	25	protein	protein	NN
cord-291950-9gtsqyfj	619	26	synthesis	synthesis	NN
cord-291950-9gtsqyfj	620	1	A	a	DT
cord-291950-9gtsqyfj	620	2	single	single	JJ
cord-291950-9gtsqyfj	620	3	amino	amino	NN
cord-291950-9gtsqyfj	620	4	acid	acid	NN
cord-291950-9gtsqyfj	620	5	change	change	NN
cord-291950-9gtsqyfj	620	6	in	in	IN
cord-291950-9gtsqyfj	620	7	protein	protein	NN
cord-291950-9gtsqyfj	620	8	synthesis	synthesis	NN
cord-291950-9gtsqyfj	620	9	initiation	initiation	NN
cord-291950-9gtsqyfj	620	10	factor	factor	NN
cord-291950-9gtsqyfj	620	11	4	4	CD
cord-291950-9gtsqyfj	620	12	G	g	NN
cord-291950-9gtsqyfj	620	13	renders	render	VBZ
cord-291950-9gtsqyfj	620	14	cap	cap	NN
cord-291950-9gtsqyfj	620	15	-	-	HYPH
cord-291950-9gtsqyfj	620	16	dependent	dependent	JJ
cord-291950-9gtsqyfj	620	17	translation	translation	NN
cord-291950-9gtsqyfj	620	18	resistant	resistant	JJ
cord-291950-9gtsqyfj	620	19	to	to	IN
cord-291950-9gtsqyfj	620	20	picornaviral	picornaviral	NNP
cord-291950-9gtsqyfj	620	21	2A	2a	CD
cord-291950-9gtsqyfj	620	22	proteases	protease	NNS
cord-291950-9gtsqyfj	621	1	Rice	Rice	NNP
cord-291950-9gtsqyfj	621	2	tungro	tungro	NNP
cord-291950-9gtsqyfj	621	3	spherical	spherical	JJ
cord-291950-9gtsqyfj	621	4	virus	virus	NN
cord-291950-9gtsqyfj	621	5	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	621	6	processing	processing	NN
cord-291950-9gtsqyfj	621	7	:	:	:
cord-291950-9gtsqyfj	621	8	identification	identification	NN
cord-291950-9gtsqyfj	621	9	of	of	IN
cord-291950-9gtsqyfj	621	10	a	a	DT
cord-291950-9gtsqyfj	621	11	virus	virus	NN
cord-291950-9gtsqyfj	621	12	-	-	HYPH
cord-291950-9gtsqyfj	621	13	encoded	encode	VBN
cord-291950-9gtsqyfj	621	14	protease	protease	NN
cord-291950-9gtsqyfj	621	15	and	and	CC
cord-291950-9gtsqyfj	621	16	mutational	mutational	JJ
cord-291950-9gtsqyfj	621	17	analysis	analysis	NN
cord-291950-9gtsqyfj	621	18	of	of	IN
cord-291950-9gtsqyfj	621	19	putative	putative	JJ
cord-291950-9gtsqyfj	621	20	cleavage	cleavage	NN
cord-291950-9gtsqyfj	621	21	sites	site	NNS
cord-291950-9gtsqyfj	621	22	Characterization	characterization	NN
cord-291950-9gtsqyfj	621	23	of	of	IN
cord-291950-9gtsqyfj	621	24	the	the	DT
cord-291950-9gtsqyfj	621	25	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	621	26	residues	residue	NNS
cord-291950-9gtsqyfj	621	27	of	of	IN
cord-291950-9gtsqyfj	621	28	the	the	DT
cord-291950-9gtsqyfj	621	29	tobacco	tobacco	NN
cord-291950-9gtsqyfj	621	30	etch	etch	NN
cord-291950-9gtsqyfj	621	31	virus	virus	NN
cord-291950-9gtsqyfj	621	32	49-kDa	49-kda	CD
cord-291950-9gtsqyfj	621	33	proteinase	proteinase	NN
cord-291950-9gtsqyfj	621	34	Autocatalytic	autocatalytic	JJ
cord-291950-9gtsqyfj	621	35	activity	activity	NN
cord-291950-9gtsqyfj	621	36	of	of	IN
cord-291950-9gtsqyfj	621	37	the	the	DT
cord-291950-9gtsqyfj	621	38	tobacco	tobacco	NN
cord-291950-9gtsqyfj	621	39	etch	etch	NN
cord-291950-9gtsqyfj	621	40	virus	virus	NN
cord-291950-9gtsqyfj	621	41	NIa	nia	JJ
cord-291950-9gtsqyfj	621	42	proteinase	proteinase	NN
cord-291950-9gtsqyfj	621	43	in	in	IN
cord-291950-9gtsqyfj	621	44	viral	viral	JJ
cord-291950-9gtsqyfj	621	45	and	and	CC
cord-291950-9gtsqyfj	621	46	foreign	foreign	JJ
cord-291950-9gtsqyfj	621	47	protein	protein	NN
cord-291950-9gtsqyfj	621	48	sequences	sequence	NNS
cord-291950-9gtsqyfj	621	49	Identification	identification	NN
cord-291950-9gtsqyfj	621	50	and	and	CC
cord-291950-9gtsqyfj	621	51	characterization	characterization	NN
cord-291950-9gtsqyfj	621	52	of	of	IN
cord-291950-9gtsqyfj	621	53	a	a	DT
cord-291950-9gtsqyfj	621	54	3C	3c	NN
cord-291950-9gtsqyfj	621	55	-	-	HYPH
cord-291950-9gtsqyfj	621	56	like	like	JJ
cord-291950-9gtsqyfj	621	57	protease	protease	NN
cord-291950-9gtsqyfj	621	58	from	from	IN
cord-291950-9gtsqyfj	621	59	rabbit	rabbit	NN
cord-291950-9gtsqyfj	621	60	hemorrhagic	hemorrhagic	JJ
cord-291950-9gtsqyfj	621	61	disease	disease	NN
cord-291950-9gtsqyfj	621	62	virus	virus	NN
cord-291950-9gtsqyfj	621	63	3C	3c	NN
cord-291950-9gtsqyfj	621	64	-	-	HYPH
cord-291950-9gtsqyfj	621	65	like	like	JJ
cord-291950-9gtsqyfj	621	66	protease	protease	NN
cord-291950-9gtsqyfj	621	67	of	of	IN
cord-291950-9gtsqyfj	621	68	rabbit	rabbit	NN
cord-291950-9gtsqyfj	621	69	hemorrhagic	hemorrhagic	JJ
cord-291950-9gtsqyfj	621	70	disease	disease	NN
cord-291950-9gtsqyfj	621	71	virus	virus	NN
cord-291950-9gtsqyfj	621	72	:	:	:
cord-291950-9gtsqyfj	621	73	identification	identification	NN
cord-291950-9gtsqyfj	621	74	of	of	IN
cord-291950-9gtsqyfj	621	75	cleavage	cleavage	NN
cord-291950-9gtsqyfj	621	76	sites	site	NNS
cord-291950-9gtsqyfj	621	77	in	in	IN
cord-291950-9gtsqyfj	621	78	the	the	DT
cord-291950-9gtsqyfj	621	79	ORF1	ORF1	NNP
cord-291950-9gtsqyfj	621	80	polyprotein	polyprotein	NN
cord-291950-9gtsqyfj	621	81	and	and	CC
cord-291950-9gtsqyfj	621	82	analysis	analysis	NN
cord-291950-9gtsqyfj	621	83	of	of	IN
cord-291950-9gtsqyfj	621	84	cleavage	cleavage	NN
cord-291950-9gtsqyfj	621	85	specificity	specificity	NN
cord-291950-9gtsqyfj	621	86	Characterisation	Characterisation	NNP
cord-291950-9gtsqyfj	621	87	and	and	CC
cord-291950-9gtsqyfj	621	88	mutational	mutational	JJ
cord-291950-9gtsqyfj	621	89	analysis	analysis	NN
cord-291950-9gtsqyfj	621	90	of	of	IN
cord-291950-9gtsqyfj	621	91	an	an	DT
cord-291950-9gtsqyfj	621	92	ORF	ORF	NNP
cord-291950-9gtsqyfj	621	93	1a	1a	NN
cord-291950-9gtsqyfj	621	94	-	-	HYPH
cord-291950-9gtsqyfj	621	95	encoding	encode	VBG
cord-291950-9gtsqyfj	621	96	proteinase	proteinase	NN
cord-291950-9gtsqyfj	621	97	domain	domain	NN
cord-291950-9gtsqyfj	621	98	responsible	responsible	JJ
cord-291950-9gtsqyfj	621	99	for	for	IN
cord-291950-9gtsqyfj	621	100	proteolytic	proteolytic	JJ
cord-291950-9gtsqyfj	621	101	processing	processing	NN
cord-291950-9gtsqyfj	621	102	of	of	IN
cord-291950-9gtsqyfj	621	103	the	the	DT
cord-291950-9gtsqyfj	621	104	infectious	infectious	JJ
cord-291950-9gtsqyfj	621	105	bronchitis	bronchitis	NN
cord-291950-9gtsqyfj	621	106	virus	virus	NN
cord-291950-9gtsqyfj	621	107	1a/1b	1a/1b	CD
cord-291950-9gtsqyfj	621	108	polyprotein	polyprotein	NNP
cord-291950-9gtsqyfj	621	109	Polyprotein	Polyprotein	NNP
cord-291950-9gtsqyfj	621	110	processing	processing	NN
cord-291950-9gtsqyfj	621	111	in	in	IN
cord-291950-9gtsqyfj	621	112	Southampton	Southampton	NNP
cord-291950-9gtsqyfj	621	113	virus	virus	NN
cord-291950-9gtsqyfj	621	114	:	:	:
cord-291950-9gtsqyfj	621	115	identification	identification	NN
cord-291950-9gtsqyfj	621	116	of	of	IN
cord-291950-9gtsqyfj	621	117	3C	3c	NN
cord-291950-9gtsqyfj	621	118	-	-	HYPH
cord-291950-9gtsqyfj	621	119	like	like	JJ
cord-291950-9gtsqyfj	621	120	protease	protease	NN
cord-291950-9gtsqyfj	621	121	cleavage	cleavage	NN
cord-291950-9gtsqyfj	621	122	sites	site	NNS
cord-291950-9gtsqyfj	621	123	by	by	IN
cord-291950-9gtsqyfj	621	124	in	in	FW
cord-291950-9gtsqyfj	621	125	vitro	vitro	FW
cord-291950-9gtsqyfj	621	126	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	621	127	Sequence	sequence	NN
cord-291950-9gtsqyfj	621	128	analysis	analysis	NN
cord-291950-9gtsqyfj	621	129	of	of	IN
cord-291950-9gtsqyfj	621	130	the	the	DT
cord-291950-9gtsqyfj	621	131	parsnip	parsnip	NNP
cord-291950-9gtsqyfj	621	132	yellow	yellow	NNP
cord-291950-9gtsqyfj	621	133	fleck	fleck	NNP
cord-291950-9gtsqyfj	621	134	virus	virus	NNP
cord-291950-9gtsqyfj	621	135	polyprotein	polyprotein	NNP
cord-291950-9gtsqyfj	621	136	:	:	:
cord-291950-9gtsqyfj	621	137	evidence	evidence	NN
cord-291950-9gtsqyfj	621	138	of	of	IN
cord-291950-9gtsqyfj	621	139	affinities	affinity	NNS
cord-291950-9gtsqyfj	621	140	with	with	IN
cord-291950-9gtsqyfj	621	141	picornaviruses	picornaviruses	NNP
cord-291950-9gtsqyfj	621	142	Temporal	Temporal	NNP
cord-291950-9gtsqyfj	621	143	modulation	modulation	NN
cord-291950-9gtsqyfj	621	144	of	of	IN
cord-291950-9gtsqyfj	621	145	an	an	DT
cord-291950-9gtsqyfj	621	146	autoprotease	autoprotease	NN
cord-291950-9gtsqyfj	621	147	is	be	VBZ
cord-291950-9gtsqyfj	621	148	crucial	crucial	JJ
cord-291950-9gtsqyfj	621	149	for	for	IN
cord-291950-9gtsqyfj	621	150	replication	replication	NN
cord-291950-9gtsqyfj	621	151	and	and	CC
cord-291950-9gtsqyfj	621	152	pathogenicity	pathogenicity	NN
cord-291950-9gtsqyfj	621	153	of	of	IN
cord-291950-9gtsqyfj	621	154	an	an	DT
cord-291950-9gtsqyfj	621	155	RNA	RNA	NNP
cord-291950-9gtsqyfj	621	156	virus	virus	NN
cord-291950-9gtsqyfj	621	157	Identification	identification	NN
cord-291950-9gtsqyfj	621	158	of	of	IN
cord-291950-9gtsqyfj	621	159	the	the	DT
cord-291950-9gtsqyfj	621	160	active	active	JJ
cord-291950-9gtsqyfj	621	161	site	site	NN
cord-291950-9gtsqyfj	621	162	of	of	IN
cord-291950-9gtsqyfj	621	163	legumain	legumain	NN
cord-291950-9gtsqyfj	622	1	links	link	VBZ
cord-291950-9gtsqyfj	622	2	it	-PRON-	PRP
cord-291950-9gtsqyfj	622	3	to	to	IN
cord-291950-9gtsqyfj	622	4	caspases	caspase	NNS
cord-291950-9gtsqyfj	622	5	,	,	,
cord-291950-9gtsqyfj	622	6	clostripain	clostripain	NNP
cord-291950-9gtsqyfj	622	7	and	and	CC
cord-291950-9gtsqyfj	622	8	gingipains	gingipain	NNS
cord-291950-9gtsqyfj	622	9	in	in	IN
cord-291950-9gtsqyfj	622	10	a	a	DT
cord-291950-9gtsqyfj	622	11	new	new	JJ
cord-291950-9gtsqyfj	622	12	clan	clan	NN
cord-291950-9gtsqyfj	622	13	of	of	IN
cord-291950-9gtsqyfj	622	14	cysteine	cysteine	NN
cord-291950-9gtsqyfj	622	15	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	622	16	Classification	Classification	NNP
cord-291950-9gtsqyfj	622	17	of	of	IN
cord-291950-9gtsqyfj	622	18	the	the	DT
cord-291950-9gtsqyfj	622	19	caspasehemoglobinase	caspasehemoglobinase	NNP
cord-291950-9gtsqyfj	622	20	fold	fold	NN
cord-291950-9gtsqyfj	622	21	:	:	:
cord-291950-9gtsqyfj	622	22	detection	detection	NN
cord-291950-9gtsqyfj	622	23	of	of	IN
cord-291950-9gtsqyfj	622	24	new	new	JJ
cord-291950-9gtsqyfj	622	25	families	family	NNS
cord-291950-9gtsqyfj	622	26	and	and	CC
cord-291950-9gtsqyfj	622	27	implications	implication	NNS
cord-291950-9gtsqyfj	622	28	for	for	IN
cord-291950-9gtsqyfj	622	29	the	the	DT
cord-291950-9gtsqyfj	622	30	origin	origin	NN
cord-291950-9gtsqyfj	622	31	of	of	IN
cord-291950-9gtsqyfj	622	32	the	the	DT
cord-291950-9gtsqyfj	622	33	eukaryotic	eukaryotic	JJ
cord-291950-9gtsqyfj	622	34	separins	separin	NNS
cord-291950-9gtsqyfj	622	35	Viral	viral	JJ
cord-291950-9gtsqyfj	622	36	inhibition	inhibition	NN
cord-291950-9gtsqyfj	622	37	of	of	IN
cord-291950-9gtsqyfj	622	38	inflammation	inflammation	NN
cord-291950-9gtsqyfj	622	39	:	:	:
cord-291950-9gtsqyfj	623	1	cowpox	cowpox	NN
cord-291950-9gtsqyfj	623	2	virus	virus	NN
cord-291950-9gtsqyfj	623	3	encodes	encode	VBZ
cord-291950-9gtsqyfj	623	4	an	an	DT
cord-291950-9gtsqyfj	623	5	inhibitor	inhibitor	NN
cord-291950-9gtsqyfj	623	6	of	of	IN
cord-291950-9gtsqyfj	623	7	the	the	DT
cord-291950-9gtsqyfj	623	8	interleukin-1	interleukin-1	NN
cord-291950-9gtsqyfj	623	9	beta	beta	NN
cord-291950-9gtsqyfj	623	10	converting	convert	VBG
cord-291950-9gtsqyfj	623	11	enzyme	enzyme	NN
cord-291950-9gtsqyfj	623	12	Granzyme	Granzyme	NNP
cord-291950-9gtsqyfj	623	13	B	B	NNP
cord-291950-9gtsqyfj	623	14	is	be	VBZ
cord-291950-9gtsqyfj	623	15	inhibited	inhibit	VBN
cord-291950-9gtsqyfj	623	16	by	by	IN
cord-291950-9gtsqyfj	623	17	the	the	DT
cord-291950-9gtsqyfj	623	18	cowpox	cowpox	NN
cord-291950-9gtsqyfj	623	19	virus	virus	NN
cord-291950-9gtsqyfj	623	20	serpin	serpin	NNP
cord-291950-9gtsqyfj	623	21	cytokine	cytokine	NN
cord-291950-9gtsqyfj	623	22	response	response	NN
cord-291950-9gtsqyfj	623	23	modifier	modifier	NN
cord-291950-9gtsqyfj	623	24	A	a	DT
cord-291950-9gtsqyfj	623	25	Activation	activation	NN
cord-291950-9gtsqyfj	623	26	of	of	IN
cord-291950-9gtsqyfj	623	27	the	the	DT
cord-291950-9gtsqyfj	623	28	native	native	JJ
cord-291950-9gtsqyfj	623	29	45-kDa	45-kda	CD
cord-291950-9gtsqyfj	623	30	precursor	precursor	NN
cord-291950-9gtsqyfj	623	31	form	form	NN
cord-291950-9gtsqyfj	623	32	of	of	IN
cord-291950-9gtsqyfj	623	33	interleukin-1-converting	interleukin-1-converting	NNP
cord-291950-9gtsqyfj	623	34	enzyme	enzyme	NN
cord-291950-9gtsqyfj	623	35	Interleukin-1β	interleukin-1β	NN
cord-291950-9gtsqyfj	623	36	converting	convert	VBG
cord-291950-9gtsqyfj	623	37	enzyme	enzyme	NN
cord-291950-9gtsqyfj	623	38	:	:	:
cord-291950-9gtsqyfj	624	1	A	a	DT
cord-291950-9gtsqyfj	624	2	novel	novel	JJ
cord-291950-9gtsqyfj	624	3	cysteine	cysteine	NN
cord-291950-9gtsqyfj	624	4	protease	protease	NN
cord-291950-9gtsqyfj	624	5	required	require	VBN
cord-291950-9gtsqyfj	624	6	for	for	IN
cord-291950-9gtsqyfj	624	7	IL-1β	IL-1β	JJR
cord-291950-9gtsqyfj	624	8	production	production	NN
cord-291950-9gtsqyfj	624	9	and	and	CC
cord-291950-9gtsqyfj	624	10	implicated	implicate	VBN
cord-291950-9gtsqyfj	624	11	in	in	IN
cord-291950-9gtsqyfj	624	12	programmed	programmed	JJ
cord-291950-9gtsqyfj	624	13	cell	cell	NN
cord-291950-9gtsqyfj	624	14	death	death	NN
cord-291950-9gtsqyfj	625	1	The	the	DT
cord-291950-9gtsqyfj	625	2	Caenorhabditis	Caenorhabditis	NNP
cord-291950-9gtsqyfj	625	3	elegans	elegan	NNS
cord-291950-9gtsqyfj	625	4	cell	cell	NN
cord-291950-9gtsqyfj	625	5	-	-	HYPH
cord-291950-9gtsqyfj	625	6	death	death	NN
cord-291950-9gtsqyfj	625	7	protein	protein	NN
cord-291950-9gtsqyfj	625	8	CED-3	CED-3	NNP
cord-291950-9gtsqyfj	625	9	is	be	VBZ
cord-291950-9gtsqyfj	625	10	a	a	DT
cord-291950-9gtsqyfj	625	11	cysteine	cysteine	NN
cord-291950-9gtsqyfj	625	12	protease	protease	NN
cord-291950-9gtsqyfj	625	13	with	with	IN
cord-291950-9gtsqyfj	625	14	substrate	substrate	NN
cord-291950-9gtsqyfj	625	15	specificities	specificity	NNS
cord-291950-9gtsqyfj	625	16	similar	similar	JJ
cord-291950-9gtsqyfj	625	17	to	to	IN
cord-291950-9gtsqyfj	625	18	those	those	DT
cord-291950-9gtsqyfj	625	19	of	of	IN
cord-291950-9gtsqyfj	625	20	the	the	DT
cord-291950-9gtsqyfj	625	21	human	human	JJ
cord-291950-9gtsqyfj	625	22	CPP32	cpp32	NN
cord-291950-9gtsqyfj	625	23	protease	protease	NN
cord-291950-9gtsqyfj	625	24	Apoptosis	Apoptosis	NNP
cord-291950-9gtsqyfj	625	25	.	.	.
cord-291950-9gtsqyfj	626	1	Placing	place	VBG
cord-291950-9gtsqyfj	626	2	death	death	NN
cord-291950-9gtsqyfj	626	3	under	under	IN
cord-291950-9gtsqyfj	626	4	control	control	NN
cord-291950-9gtsqyfj	626	5	Inhibition	inhibition	NN
cord-291950-9gtsqyfj	626	6	of	of	IN
cord-291950-9gtsqyfj	626	7	death	death	NN
cord-291950-9gtsqyfj	626	8	receptor	receptor	NN
cord-291950-9gtsqyfj	626	9	signals	signal	NNS
cord-291950-9gtsqyfj	626	10	by	by	IN
cord-291950-9gtsqyfj	626	11	cellular	cellular	JJ
cord-291950-9gtsqyfj	626	12	FLIP	flip	NN
cord-291950-9gtsqyfj	627	1	The	the	DT
cord-291950-9gtsqyfj	627	2	two	two	CD
cord-291950-9gtsqyfj	627	3	cysteine	cysteine	NN
cord-291950-9gtsqyfj	627	4	endopeptidases	endopeptidase	NNS
cord-291950-9gtsqyfj	627	5	of	of	IN
cord-291950-9gtsqyfj	627	6	legume	legume	JJ
cord-291950-9gtsqyfj	627	7	seeds	seed	NNS
cord-291950-9gtsqyfj	627	8	:	:	:
cord-291950-9gtsqyfj	627	9	purification	purification	NN
cord-291950-9gtsqyfj	627	10	and	and	CC
cord-291950-9gtsqyfj	627	11	characterization	characterization	NN
cord-291950-9gtsqyfj	627	12	by	by	IN
cord-291950-9gtsqyfj	627	13	use	use	NN
cord-291950-9gtsqyfj	627	14	of	of	IN
cord-291950-9gtsqyfj	627	15	specific	specific	JJ
cord-291950-9gtsqyfj	627	16	fluorometric	fluorometric	JJ
cord-291950-9gtsqyfj	627	17	assays	assay	NNS
cord-291950-9gtsqyfj	627	18	Vacuolar	Vacuolar	NNP
cord-291950-9gtsqyfj	627	19	processing	processing	NN
cord-291950-9gtsqyfj	627	20	enzyme	enzyme	NN
cord-291950-9gtsqyfj	627	21	responsible	responsible	JJ
cord-291950-9gtsqyfj	627	22	for	for	IN
cord-291950-9gtsqyfj	627	23	maturation	maturation	NN
cord-291950-9gtsqyfj	627	24	of	of	IN
cord-291950-9gtsqyfj	627	25	seed	seed	NN
cord-291950-9gtsqyfj	627	26	proteins	protein	NNS
cord-291950-9gtsqyfj	628	1	In	in	IN
cord-291950-9gtsqyfj	628	2	vitro	vitro	FW
cord-291950-9gtsqyfj	628	3	splicing	splicing	NN
cord-291950-9gtsqyfj	628	4	of	of	IN
cord-291950-9gtsqyfj	628	5	concanavalin	concanavalin	NNP
cord-291950-9gtsqyfj	629	1	A	a	DT
cord-291950-9gtsqyfj	629	2	is	be	VBZ
cord-291950-9gtsqyfj	629	3	catalyzed	catalyze	VBN
cord-291950-9gtsqyfj	629	4	by	by	IN
cord-291950-9gtsqyfj	629	5	asparaginyl	asparaginyl	NNP
cord-291950-9gtsqyfj	629	6	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	629	7	Cloning	cloning	NN
cord-291950-9gtsqyfj	629	8	,	,	,
cord-291950-9gtsqyfj	629	9	isolation	isolation	NN
cord-291950-9gtsqyfj	629	10	,	,	,
cord-291950-9gtsqyfj	629	11	and	and	CC
cord-291950-9gtsqyfj	629	12	characterization	characterization	NN
cord-291950-9gtsqyfj	629	13	of	of	IN
cord-291950-9gtsqyfj	629	14	mammalian	mammalian	JJ
cord-291950-9gtsqyfj	629	15	legumain	legumain	NN
cord-291950-9gtsqyfj	629	16	,	,	,
cord-291950-9gtsqyfj	629	17	an	an	DT
cord-291950-9gtsqyfj	629	18	asparaginyl	asparaginyl	NN
cord-291950-9gtsqyfj	629	19	endopeptidase	endopeptidase	NN
cord-291950-9gtsqyfj	629	20	Expression	expression	NN
cord-291950-9gtsqyfj	629	21	and	and	CC
cord-291950-9gtsqyfj	629	22	partial	partial	JJ
cord-291950-9gtsqyfj	629	23	characterization	characterization	NN
cord-291950-9gtsqyfj	629	24	of	of	IN
cord-291950-9gtsqyfj	629	25	a	a	DT
cord-291950-9gtsqyfj	629	26	cathepsin	cathepsin	NN
cord-291950-9gtsqyfj	629	27	B	b	NN
cord-291950-9gtsqyfj	629	28	-	-	HYPH
cord-291950-9gtsqyfj	629	29	like	like	JJ
cord-291950-9gtsqyfj	629	30	enzyme	enzyme	NN
cord-291950-9gtsqyfj	629	31	(	(	-LRB-
cord-291950-9gtsqyfj	629	32	Sm31	Sm31	NNP
cord-291950-9gtsqyfj	629	33	)	)	-RRB-
cord-291950-9gtsqyfj	629	34	and	and	CC
cord-291950-9gtsqyfj	629	35	a	a	DT
cord-291950-9gtsqyfj	629	36	proposed	propose	VBN
cord-291950-9gtsqyfj	629	37	'	'	``
cord-291950-9gtsqyfj	629	38	haemoglobinase	haemoglobinase	NNP
cord-291950-9gtsqyfj	629	39	'	'	''
cord-291950-9gtsqyfj	629	40	(	(	-LRB-
cord-291950-9gtsqyfj	629	41	Sm32	Sm32	NNP
cord-291950-9gtsqyfj	629	42	)	)	-RRB-
cord-291950-9gtsqyfj	629	43	from	from	IN
cord-291950-9gtsqyfj	629	44	Schistosoma	Schistosoma	NNP
cord-291950-9gtsqyfj	629	45	mansoni	mansoni	NNP
cord-291950-9gtsqyfj	629	46	Structural	structural	JJ
cord-291950-9gtsqyfj	629	47	and	and	CC
cord-291950-9gtsqyfj	629	48	molecular	molecular	JJ
cord-291950-9gtsqyfj	629	49	mechanism	mechanism	NN
cord-291950-9gtsqyfj	629	50	for	for	IN
cord-291950-9gtsqyfj	629	51	autoprocessing	autoprocessing	NN
cord-291950-9gtsqyfj	629	52	of	of	IN
cord-291950-9gtsqyfj	629	53	MARTX	MARTX	NNP
cord-291950-9gtsqyfj	629	54	toxin	toxin	NN
cord-291950-9gtsqyfj	629	55	of	of	IN
cord-291950-9gtsqyfj	629	56	Vibrio	Vibrio	NNP
cord-291950-9gtsqyfj	629	57	cholerae	cholerae	NN
cord-291950-9gtsqyfj	629	58	at	at	IN
cord-291950-9gtsqyfj	629	59	multiple	multiple	JJ
cord-291950-9gtsqyfj	629	60	sites	site	NNS
cord-291950-9gtsqyfj	629	61	Small	small	JJ
cord-291950-9gtsqyfj	629	62	molecule	molecule	NN
cord-291950-9gtsqyfj	629	63	-	-	HYPH
cord-291950-9gtsqyfj	629	64	induced	induce	VBN
cord-291950-9gtsqyfj	629	65	allosteric	allosteric	JJ
cord-291950-9gtsqyfj	629	66	activation	activation	NN
cord-291950-9gtsqyfj	629	67	of	of	IN
cord-291950-9gtsqyfj	629	68	the	the	DT
cord-291950-9gtsqyfj	629	69	Vibrio	Vibrio	NNP
cord-291950-9gtsqyfj	629	70	cholerae	cholerae	NN
cord-291950-9gtsqyfj	629	71	RTX	RTX	NNP
cord-291950-9gtsqyfj	629	72	cysteine	cysteine	NN
cord-291950-9gtsqyfj	629	73	protease	protease	NN
cord-291950-9gtsqyfj	629	74	domain	domain	NN
cord-291950-9gtsqyfj	629	75	Cloning	cloning	NN
cord-291950-9gtsqyfj	629	76	,	,	,
cord-291950-9gtsqyfj	629	77	expression	expression	NN
cord-291950-9gtsqyfj	629	78	,	,	,
cord-291950-9gtsqyfj	629	79	and	and	CC
cord-291950-9gtsqyfj	629	80	sequencing	sequencing	NN
cord-291950-9gtsqyfj	629	81	of	of	IN
cord-291950-9gtsqyfj	629	82	a	a	DT
cord-291950-9gtsqyfj	629	83	protease	protease	NN
cord-291950-9gtsqyfj	629	84	gene	gene	NN
cord-291950-9gtsqyfj	629	85	from	from	IN
cord-291950-9gtsqyfj	629	86	Bacteroides	Bacteroides	NNP
cord-291950-9gtsqyfj	629	87	forsythus	forsythus	NN
cord-291950-9gtsqyfj	629	88	ATCC	ATCC	NNP
cord-291950-9gtsqyfj	629	89	43037	43037	CD
cord-291950-9gtsqyfj	629	90	in	in	IN
cord-291950-9gtsqyfj	629	91	Escherichia	Escherichia	NNP
cord-291950-9gtsqyfj	629	92	coli	coli	NNS
cord-291950-9gtsqyfj	630	1	A	a	DT
cord-291950-9gtsqyfj	630	2	5-year	5-year	CD
cord-291950-9gtsqyfj	630	3	longitudinal	longitudinal	JJ
cord-291950-9gtsqyfj	630	4	study	study	NN
cord-291950-9gtsqyfj	630	5	of	of	IN
cord-291950-9gtsqyfj	630	6	Tannerella	Tannerella	NNP
cord-291950-9gtsqyfj	630	7	forsythia	forsythia	NN
cord-291950-9gtsqyfj	630	8	prtH	prth	SYM
cord-291950-9gtsqyfj	630	9	genotype	genotype	NNP
cord-291950-9gtsqyfj	630	10	:	:	:
cord-291950-9gtsqyfj	630	11	association	association	NN
cord-291950-9gtsqyfj	630	12	with	with	IN
cord-291950-9gtsqyfj	630	13	loss	loss	NN
cord-291950-9gtsqyfj	630	14	of	of	IN
cord-291950-9gtsqyfj	630	15	attachment	attachment	NN
cord-291950-9gtsqyfj	630	16	Prediction	Prediction	NNP
cord-291950-9gtsqyfj	630	17	of	of	IN
cord-291950-9gtsqyfj	630	18	a	a	DT
cord-291950-9gtsqyfj	630	19	caspase	caspase	NN
cord-291950-9gtsqyfj	630	20	-	-	HYPH
cord-291950-9gtsqyfj	630	21	like	like	JJ
cord-291950-9gtsqyfj	630	22	fold	fold	NN
cord-291950-9gtsqyfj	630	23	in	in	IN
cord-291950-9gtsqyfj	630	24	Tannerella	tannerella	NN
cord-291950-9gtsqyfj	630	25	forsythia	forsythia	NN
cord-291950-9gtsqyfj	630	26	virulence	virulence	NN
cord-291950-9gtsqyfj	630	27	factor	factor	NN
cord-291950-9gtsqyfj	630	28	PrtH	PrtH	NNP
cord-291950-9gtsqyfj	630	29	Adenovirus	Adenovirus	NNP
cord-291950-9gtsqyfj	630	30	endopeptidases	endopeptidase	VBZ
cord-291950-9gtsqyfj	630	31	Crystal	Crystal	NNP
cord-291950-9gtsqyfj	630	32	structure	structure	NN
cord-291950-9gtsqyfj	630	33	of	of	IN
cord-291950-9gtsqyfj	630	34	the	the	DT
cord-291950-9gtsqyfj	630	35	human	human	JJ
cord-291950-9gtsqyfj	630	36	adenovirus	adenovirus	NN
cord-291950-9gtsqyfj	630	37	proteinase	proteinase	NN
cord-291950-9gtsqyfj	630	38	with	with	IN
cord-291950-9gtsqyfj	630	39	its	-PRON-	PRP$
cord-291950-9gtsqyfj	630	40	11	11	CD
cord-291950-9gtsqyfj	630	41	amino	amino	NN
cord-291950-9gtsqyfj	630	42	acid	acid	NN
cord-291950-9gtsqyfj	630	43	cofactor	cofactor	NN
cord-291950-9gtsqyfj	630	44	Activation	activation	NN
cord-291950-9gtsqyfj	630	45	of	of	IN
cord-291950-9gtsqyfj	630	46	adenovirus	adenovirus	NN
cord-291950-9gtsqyfj	630	47	-	-	HYPH
cord-291950-9gtsqyfj	630	48	coded	code	VBN
cord-291950-9gtsqyfj	630	49	protease	protease	NN
cord-291950-9gtsqyfj	630	50	and	and	CC
cord-291950-9gtsqyfj	630	51	processing	processing	NN
cord-291950-9gtsqyfj	630	52	of	of	IN
cord-291950-9gtsqyfj	630	53	preterminal	preterminal	JJ
cord-291950-9gtsqyfj	630	54	protein	protein	NN
cord-291950-9gtsqyfj	630	55	Yersinia	Yersinia	NNP
cord-291950-9gtsqyfj	630	56	enterocolitica	enterocolitica	NNP
cord-291950-9gtsqyfj	631	1	YopP	yopp	NN
cord-291950-9gtsqyfj	631	2	-	-	HYPH
cord-291950-9gtsqyfj	631	3	induced	induce	VBN
cord-291950-9gtsqyfj	631	4	apoptosis	apoptosis	NN
cord-291950-9gtsqyfj	631	5	of	of	IN
cord-291950-9gtsqyfj	631	6	macrophages	macrophage	NNS
cord-291950-9gtsqyfj	631	7	involves	involve	VBZ
cord-291950-9gtsqyfj	631	8	the	the	DT
cord-291950-9gtsqyfj	631	9	apoptotic	apoptotic	JJ
cord-291950-9gtsqyfj	631	10	signaling	signal	VBG
cord-291950-9gtsqyfj	631	11	cascade	cascade	NN
cord-291950-9gtsqyfj	631	12	upstream	upstream	RB
cord-291950-9gtsqyfj	631	13	of	of	IN
cord-291950-9gtsqyfj	631	14	bid	bid	NN
cord-291950-9gtsqyfj	631	15	Gly	Gly	NNP
cord-291950-9gtsqyfj	631	16	-	-	HYPH
cord-291950-9gtsqyfj	631	17	Gly	Gly	NNP
cord-291950-9gtsqyfj	631	18	-	-	HYPH
cord-291950-9gtsqyfj	631	19	X	X	NNP
cord-291950-9gtsqyfj	631	20	,	,	,
cord-291950-9gtsqyfj	631	21	a	a	DT
cord-291950-9gtsqyfj	631	22	novel	novel	JJ
cord-291950-9gtsqyfj	631	23	consensus	consensus	NN
cord-291950-9gtsqyfj	631	24	sequence	sequence	NN
cord-291950-9gtsqyfj	631	25	for	for	IN
cord-291950-9gtsqyfj	631	26	the	the	DT
cord-291950-9gtsqyfj	631	27	proteolytic	proteolytic	JJ
cord-291950-9gtsqyfj	631	28	processing	processing	NN
cord-291950-9gtsqyfj	631	29	of	of	IN
cord-291950-9gtsqyfj	631	30	viral	viral	JJ
cord-291950-9gtsqyfj	631	31	and	and	CC
cord-291950-9gtsqyfj	631	32	cellular	cellular	JJ
cord-291950-9gtsqyfj	631	33	proteins	protein	NNS
cord-291950-9gtsqyfj	631	34	Isolation	isolation	NN
cord-291950-9gtsqyfj	631	35	and	and	CC
cord-291950-9gtsqyfj	631	36	characterization	characterization	NN
cord-291950-9gtsqyfj	631	37	of	of	IN
cord-291950-9gtsqyfj	631	38	virulence	virulence	NN
cord-291950-9gtsqyfj	631	39	gene	gene	NN
cord-291950-9gtsqyfj	631	40	psvA	psva	JJ
cord-291950-9gtsqyfj	631	41	on	on	IN
cord-291950-9gtsqyfj	631	42	a	a	DT
cord-291950-9gtsqyfj	631	43	plasmid	plasmid	NN
cord-291950-9gtsqyfj	631	44	of	of	IN
cord-291950-9gtsqyfj	631	45	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	631	46	syringae	syringae	NN
cord-291950-9gtsqyfj	631	47	pv	pv	NN
cord-291950-9gtsqyfj	631	48	.	.	.
cord-291950-9gtsqyfj	632	1	eriobotryae	eriobotryae	NNP
cord-291950-9gtsqyfj	632	2	ElaD	ElaD	NNP
cord-291950-9gtsqyfj	632	3	,	,	,
cord-291950-9gtsqyfj	632	4	a	a	DT
cord-291950-9gtsqyfj	632	5	deubiquitinating	deubiquitinating	NN
cord-291950-9gtsqyfj	632	6	protease	protease	NN
cord-291950-9gtsqyfj	632	7	expressed	express	VBN
cord-291950-9gtsqyfj	632	8	by	by	IN
cord-291950-9gtsqyfj	632	9	E.	E.	NNP
cord-291950-9gtsqyfj	632	10	coli	coli	NNS
cord-291950-9gtsqyfj	632	11	SseL	SseL	NNP
cord-291950-9gtsqyfj	632	12	,	,	,
cord-291950-9gtsqyfj	632	13	a	a	DT
cord-291950-9gtsqyfj	632	14	Salmonella	Salmonella	NNP
cord-291950-9gtsqyfj	632	15	deubiquitinase	deubiquitinase	NN
cord-291950-9gtsqyfj	632	16	required	require	VBN
cord-291950-9gtsqyfj	632	17	for	for	IN
cord-291950-9gtsqyfj	632	18	macrophage	macrophage	NN
cord-291950-9gtsqyfj	632	19	killing	killing	NN
cord-291950-9gtsqyfj	632	20	and	and	CC
cord-291950-9gtsqyfj	632	21	virulence	virulence	NN
cord-291950-9gtsqyfj	632	22	Mutational	Mutational	NNP
cord-291950-9gtsqyfj	632	23	analysis	analysis	NN
cord-291950-9gtsqyfj	632	24	of	of	IN
cord-291950-9gtsqyfj	632	25	the	the	DT
cord-291950-9gtsqyfj	632	26	active	active	JJ
cord-291950-9gtsqyfj	632	27	site	site	NN
cord-291950-9gtsqyfj	632	28	of	of	IN
cord-291950-9gtsqyfj	632	29	Pseudomonas	Pseudomonas	NNP
cord-291950-9gtsqyfj	632	30	fluorescens	fluorescen	VBD
cord-291950-9gtsqyfj	632	31	pyrrolidone	pyrrolidone	NNP
cord-291950-9gtsqyfj	632	32	carboxyl	carboxyl	NN
cord-291950-9gtsqyfj	632	33	peptidase	peptidase	NN
cord-291950-9gtsqyfj	632	34	Pyroglutamyl	Pyroglutamyl	NNP
cord-291950-9gtsqyfj	632	35	-	-	HYPH
cord-291950-9gtsqyfj	632	36	peptidase	peptidase	NN
cord-291950-9gtsqyfj	632	37	I	i	NN
cord-291950-9gtsqyfj	632	38	:	:	:
cord-291950-9gtsqyfj	632	39	cloning	clone	VBG
cord-291950-9gtsqyfj	632	40	,	,	,
cord-291950-9gtsqyfj	632	41	sequencing	sequencing	NN
cord-291950-9gtsqyfj	632	42	,	,	,
cord-291950-9gtsqyfj	632	43	and	and	CC
cord-291950-9gtsqyfj	632	44	characterisation	characterisation	NN
cord-291950-9gtsqyfj	632	45	of	of	IN
cord-291950-9gtsqyfj	632	46	the	the	DT
cord-291950-9gtsqyfj	632	47	recombinant	recombinant	JJ
cord-291950-9gtsqyfj	632	48	human	human	JJ
cord-291950-9gtsqyfj	632	49	enzyme	enzyme	NN
cord-291950-9gtsqyfj	632	50	Autoproteolysis	Autoproteolysis	NNP
cord-291950-9gtsqyfj	632	51	in	in	IN
cord-291950-9gtsqyfj	632	52	hedgehog	hedgehog	NN
cord-291950-9gtsqyfj	632	53	protein	protein	NN
cord-291950-9gtsqyfj	632	54	biogenesis	biogenesis	NN
cord-291950-9gtsqyfj	633	1	Sitedirected	sitedirected	JJ
cord-291950-9gtsqyfj	633	2	alteration	alteration	NN
cord-291950-9gtsqyfj	633	3	of	of	IN
cord-291950-9gtsqyfj	633	4	serine	serine	JJ
cord-291950-9gtsqyfj	633	5	82	82	CD
cord-291950-9gtsqyfj	633	6	causes	cause	NNS
cord-291950-9gtsqyfj	633	7	nonproductive	nonproductive	JJ
cord-291950-9gtsqyfj	633	8	chain	chain	NN
cord-291950-9gtsqyfj	633	9	cleavage	cleavage	NN
cord-291950-9gtsqyfj	633	10	in	in	IN
cord-291950-9gtsqyfj	633	11	prohistidine	prohistidine	JJ
cord-291950-9gtsqyfj	633	12	decarboxylase	decarboxylase	NN
cord-291950-9gtsqyfj	634	1	The	the	DT
cord-291950-9gtsqyfj	634	2	product	product	NN
cord-291950-9gtsqyfj	634	3	of	of	IN
cord-291950-9gtsqyfj	634	4	hedgehog	hedgehog	NNP
cord-291950-9gtsqyfj	634	5	autoproteolytic	autoproteolytic	NNP
cord-291950-9gtsqyfj	634	6	cleavage	cleavage	NN
cord-291950-9gtsqyfj	634	7	active	active	JJ
cord-291950-9gtsqyfj	634	8	in	in	IN
cord-291950-9gtsqyfj	634	9	local	local	JJ
cord-291950-9gtsqyfj	634	10	and	and	CC
cord-291950-9gtsqyfj	634	11	long	long	JJ
cord-291950-9gtsqyfj	634	12	-	-	HYPH
cord-291950-9gtsqyfj	634	13	range	range	NN
cord-291950-9gtsqyfj	634	14	signalling	signal	VBG
cord-291950-9gtsqyfj	634	15	Crystal	Crystal	NNP
cord-291950-9gtsqyfj	634	16	structure	structure	NN
cord-291950-9gtsqyfj	634	17	of	of	IN
cord-291950-9gtsqyfj	634	18	a	a	DT
cord-291950-9gtsqyfj	634	19	hedgehog	hedgehog	NN
cord-291950-9gtsqyfj	634	20	autoprocessing	autoprocesse	VBG
cord-291950-9gtsqyfj	634	21	domain	domain	NN
cord-291950-9gtsqyfj	634	22	:	:	:
cord-291950-9gtsqyfj	634	23	homology	homology	NN
cord-291950-9gtsqyfj	634	24	between	between	IN
cord-291950-9gtsqyfj	634	25	hedgehog	hedgehog	NN
cord-291950-9gtsqyfj	634	26	and	and	CC
cord-291950-9gtsqyfj	634	27	self	self	NN
cord-291950-9gtsqyfj	634	28	-	-	HYPH
cord-291950-9gtsqyfj	634	29	splicing	splice	VBG
cord-291950-9gtsqyfj	634	30	proteins	protein	NNS
cord-291950-9gtsqyfj	634	31	Asparagine	asparagine	IN
cord-291950-9gtsqyfj	634	32	peptide	peptide	NN
cord-291950-9gtsqyfj	634	33	lyases	lyase	NNS
cord-291950-9gtsqyfj	634	34	:	:	:
cord-291950-9gtsqyfj	635	1	a	a	DT
cord-291950-9gtsqyfj	635	2	seventh	seventh	JJ
cord-291950-9gtsqyfj	635	3	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	635	4	type	type	NN
cord-291950-9gtsqyfj	635	5	of	of	IN
cord-291950-9gtsqyfj	635	6	proteolytic	proteolytic	JJ
cord-291950-9gtsqyfj	635	7	enzymes	enzyme	NNS
cord-291950-9gtsqyfj	635	8	Crystal	Crystal	NNP
cord-291950-9gtsqyfj	635	9	structures	structure	NNS
cord-291950-9gtsqyfj	635	10	of	of	IN
cord-291950-9gtsqyfj	635	11	Staphylococcus	Staphylococcus	NNP
cord-291950-9gtsqyfj	635	12	aureus	aureus	NN
cord-291950-9gtsqyfj	635	13	sortase	sortase	NNP
cord-291950-9gtsqyfj	635	14	A	A	NNP
cord-291950-9gtsqyfj	635	15	and	and	CC
cord-291950-9gtsqyfj	635	16	its	-PRON-	PRP$
cord-291950-9gtsqyfj	635	17	substrate	substrate	NN
cord-291950-9gtsqyfj	635	18	complex	complex	JJ
cord-291950-9gtsqyfj	636	1	An	an	DT
cord-291950-9gtsqyfj	636	2	iron	iron	NN
cord-291950-9gtsqyfj	636	3	-	-	HYPH
cord-291950-9gtsqyfj	636	4	regulated	regulate	VBN
cord-291950-9gtsqyfj	636	5	sortase	sortase	NNP
cord-291950-9gtsqyfj	636	6	anchors	anchor	NNS
cord-291950-9gtsqyfj	636	7	a	a	DT
cord-291950-9gtsqyfj	636	8	class	class	NN
cord-291950-9gtsqyfj	636	9	of	of	IN
cord-291950-9gtsqyfj	636	10	surface	surface	NN
cord-291950-9gtsqyfj	636	11	protein	protein	NN
cord-291950-9gtsqyfj	636	12	during	during	IN
cord-291950-9gtsqyfj	636	13	Staphylococcus	Staphylococcus	NNP
cord-291950-9gtsqyfj	636	14	aureus	aureus	NN
cord-291950-9gtsqyfj	636	15	pathogenesis	pathogenesis	NN
cord-291950-9gtsqyfj	636	16	Specificity	Specificity	NNP
cord-291950-9gtsqyfj	636	17	of	of	IN
cord-291950-9gtsqyfj	636	18	L	L	NNP
cord-291950-9gtsqyfj	636	19	,	,	,
cord-291950-9gtsqyfj	636	20	D	D	NNP
cord-291950-9gtsqyfj	636	21	-	-	HYPH
cord-291950-9gtsqyfj	636	22	transpeptidases	transpeptidases	NNP
cord-291950-9gtsqyfj	636	23	from	from	IN
cord-291950-9gtsqyfj	636	24	gram	gram	NN
cord-291950-9gtsqyfj	636	25	-	-	HYPH
cord-291950-9gtsqyfj	636	26	positive	positive	JJ
cord-291950-9gtsqyfj	636	27	bacteria	bacteria	NNS
cord-291950-9gtsqyfj	636	28	producing	produce	VBG
cord-291950-9gtsqyfj	636	29	different	different	JJ
cord-291950-9gtsqyfj	636	30	peptidoglycan	peptidoglycan	NN
cord-291950-9gtsqyfj	636	31	chemotypes	chemotypes	NNP
cord-291950-9gtsqyfj	636	32	Crystal	Crystal	NNP
cord-291950-9gtsqyfj	636	33	structure	structure	NN
cord-291950-9gtsqyfj	636	34	of	of	IN
cord-291950-9gtsqyfj	636	35	a	a	DT
cord-291950-9gtsqyfj	636	36	novel	novel	NN
cord-291950-9gtsqyfj	636	37	β	β	NN
cord-291950-9gtsqyfj	636	38	-	-	HYPH
cord-291950-9gtsqyfj	636	39	lactam	lactam	NNP
cord-291950-9gtsqyfj	636	40	-	-	HYPH
cord-291950-9gtsqyfj	636	41	insensitive	insensitive	JJ
cord-291950-9gtsqyfj	636	42	peptidoglycan	peptidoglycan	NN
cord-291950-9gtsqyfj	636	43	transpeptidase	transpeptidase	NN
cord-291950-9gtsqyfj	637	1	A	a	DT
cord-291950-9gtsqyfj	637	2	second	second	JJ
cord-291950-9gtsqyfj	637	3	hepatitis	hepatitis	NN
cord-291950-9gtsqyfj	637	4	C	c	NN
cord-291950-9gtsqyfj	637	5	virus	virus	NN
cord-291950-9gtsqyfj	637	6	-	-	HYPH
cord-291950-9gtsqyfj	637	7	encoded	encode	VBN
cord-291950-9gtsqyfj	637	8	proteinase	proteinase	NN
cord-291950-9gtsqyfj	637	9	Two	two	CD
cord-291950-9gtsqyfj	637	10	distinct	distinct	JJ
cord-291950-9gtsqyfj	637	11	proteinase	proteinase	NN
cord-291950-9gtsqyfj	637	12	activities	activity	NNS
cord-291950-9gtsqyfj	637	13	required	require	VBN
cord-291950-9gtsqyfj	637	14	for	for	IN
cord-291950-9gtsqyfj	637	15	the	the	DT
cord-291950-9gtsqyfj	637	16	processing	processing	NN
cord-291950-9gtsqyfj	637	17	of	of	IN
cord-291950-9gtsqyfj	637	18	a	a	DT
cord-291950-9gtsqyfj	637	19	putative	putative	JJ
cord-291950-9gtsqyfj	637	20	nonstructural	nonstructural	JJ
cord-291950-9gtsqyfj	637	21	precursor	precursor	NN
cord-291950-9gtsqyfj	637	22	protein	protein	NN
cord-291950-9gtsqyfj	637	23	of	of	IN
cord-291950-9gtsqyfj	637	24	hepatitis	hepatitis	NNP
cord-291950-9gtsqyfj	637	25	C	C	NNP
cord-291950-9gtsqyfj	637	26	virus	virus	NN
cord-291950-9gtsqyfj	637	27	Structure	Structure	NNP
cord-291950-9gtsqyfj	637	28	of	of	IN
cord-291950-9gtsqyfj	637	29	the	the	DT
cord-291950-9gtsqyfj	637	30	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	637	31	domain	domain	NN
cord-291950-9gtsqyfj	637	32	of	of	IN
cord-291950-9gtsqyfj	637	33	the	the	DT
cord-291950-9gtsqyfj	637	34	hepatitis	hepatitis	NN
cord-291950-9gtsqyfj	637	35	C	C	NNP
cord-291950-9gtsqyfj	637	36	virus	virus	NN
cord-291950-9gtsqyfj	637	37	NS2	NS2	NNP
cord-291950-9gtsqyfj	637	38	-	-	HYPH
cord-291950-9gtsqyfj	637	39	3	3	CD
cord-291950-9gtsqyfj	637	40	protease	protease	NN
cord-291950-9gtsqyfj	637	41	Identification	identification	NN
cord-291950-9gtsqyfj	637	42	of	of	IN
cord-291950-9gtsqyfj	637	43	the	the	DT
cord-291950-9gtsqyfj	637	44	active	active	JJ
cord-291950-9gtsqyfj	637	45	site	site	NN
cord-291950-9gtsqyfj	637	46	residues	residue	NNS
cord-291950-9gtsqyfj	637	47	in	in	IN
cord-291950-9gtsqyfj	637	48	the	the	DT
cord-291950-9gtsqyfj	637	49	nsP2	nsp2	NN
cord-291950-9gtsqyfj	637	50	proteinase	proteinase	NN
cord-291950-9gtsqyfj	637	51	of	of	IN
cord-291950-9gtsqyfj	637	52	sindbis	sindbis	NNP
cord-291950-9gtsqyfj	637	53	virus	virus	NN
cord-291950-9gtsqyfj	638	1	The	the	DT
cord-291950-9gtsqyfj	638	2	crystal	crystal	JJ
cord-291950-9gtsqyfj	638	3	structure	structure	NN
cord-291950-9gtsqyfj	638	4	of	of	IN
cord-291950-9gtsqyfj	638	5	the	the	DT
cord-291950-9gtsqyfj	638	6	Venezuelan	venezuelan	JJ
cord-291950-9gtsqyfj	638	7	equine	equine	NN
cord-291950-9gtsqyfj	638	8	encephalitis	encephalitis	RB
cord-291950-9gtsqyfj	638	9	alphavirus	alphavirus	NN
cord-291950-9gtsqyfj	639	1	nsP2	nsP2	NNP
cord-291950-9gtsqyfj	639	2	protease	protease	NNP
cord-291950-9gtsqyfj	639	3	Threedimensional	Threedimensional	NNP
cord-291950-9gtsqyfj	639	4	structure	structure	NN
cord-291950-9gtsqyfj	639	5	of	of	IN
cord-291950-9gtsqyfj	639	6	human	human	JJ
cord-291950-9gtsqyfj	639	7	γ	γ	NN
cord-291950-9gtsqyfj	639	8	-	-	HYPH
cord-291950-9gtsqyfj	639	9	glutamyl	glutamyl	NNP
cord-291950-9gtsqyfj	639	10	hydrolase	hydrolase	NNP
cord-291950-9gtsqyfj	639	11	.	.	.
cord-291950-9gtsqyfj	640	1	A	a	DT
cord-291950-9gtsqyfj	640	2	class	class	NN
cord-291950-9gtsqyfj	640	3	I	-PRON-	PRP
cord-291950-9gtsqyfj	640	4	glutamine	glutamine	VBP
cord-291950-9gtsqyfj	640	5	amidotransferase	amidotransferase	NN
cord-291950-9gtsqyfj	640	6	adapted	adapt	VBD
cord-291950-9gtsqyfj	640	7	for	for	IN
cord-291950-9gtsqyfj	640	8	a	a	DT
cord-291950-9gtsqyfj	640	9	complex	complex	JJ
cord-291950-9gtsqyfj	640	10	substrate	substrate	NN
cord-291950-9gtsqyfj	640	11	Dali	Dali	NNP
cord-291950-9gtsqyfj	640	12	:	:	:
cord-291950-9gtsqyfj	641	1	a	a	DT
cord-291950-9gtsqyfj	641	2	network	network	NN
cord-291950-9gtsqyfj	641	3	tool	tool	NN
cord-291950-9gtsqyfj	641	4	for	for	IN
cord-291950-9gtsqyfj	641	5	protein	protein	NN
cord-291950-9gtsqyfj	641	6	structure	structure	NN
cord-291950-9gtsqyfj	641	7	comparison	comparison	NN
cord-291950-9gtsqyfj	641	8	Identification	identification	NN
cord-291950-9gtsqyfj	641	9	of	of	IN
cord-291950-9gtsqyfj	641	10	essential	essential	JJ
cord-291950-9gtsqyfj	641	11	residues	residue	NNS
cord-291950-9gtsqyfj	641	12	in	in	IN
cord-291950-9gtsqyfj	641	13	potyvirus	potyvirus	JJ
cord-291950-9gtsqyfj	641	14	proteinase	proteinase	NN
cord-291950-9gtsqyfj	641	15	HC	HC	NNP
cord-291950-9gtsqyfj	641	16	-	-	HYPH
cord-291950-9gtsqyfj	641	17	Pro	Pro	NNP
cord-291950-9gtsqyfj	641	18	by	by	IN
cord-291950-9gtsqyfj	641	19	site	site	NN
cord-291950-9gtsqyfj	641	20	-	-	HYPH
cord-291950-9gtsqyfj	641	21	directed	direct	VBN
cord-291950-9gtsqyfj	641	22	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	641	23	Cotranslational	Cotranslational	NNP
cord-291950-9gtsqyfj	641	24	autoproteolysis	autoproteolysis	NN
cord-291950-9gtsqyfj	641	25	involved	involve	VBN
cord-291950-9gtsqyfj	641	26	in	in	IN
cord-291950-9gtsqyfj	641	27	gene	gene	NN
cord-291950-9gtsqyfj	641	28	expression	expression	NN
cord-291950-9gtsqyfj	641	29	from	from	IN
cord-291950-9gtsqyfj	641	30	a	a	DT
cord-291950-9gtsqyfj	641	31	double	double	RB
cord-291950-9gtsqyfj	641	32	-	-	HYPH
cord-291950-9gtsqyfj	641	33	stranded	strand	VBN
cord-291950-9gtsqyfj	641	34	RNA	RNA	NNP
cord-291950-9gtsqyfj	641	35	genetic	genetic	JJ
cord-291950-9gtsqyfj	641	36	element	element	NN
cord-291950-9gtsqyfj	641	37	associated	associate	VBN
cord-291950-9gtsqyfj	641	38	with	with	IN
cord-291950-9gtsqyfj	641	39	hypovirulence	hypovirulence	NN
cord-291950-9gtsqyfj	641	40	of	of	IN
cord-291950-9gtsqyfj	641	41	the	the	DT
cord-291950-9gtsqyfj	641	42	chestnut	chestnut	NN
cord-291950-9gtsqyfj	641	43	blight	blight	NN
cord-291950-9gtsqyfj	641	44	fungus	fungus	NN
cord-291950-9gtsqyfj	641	45	Gene	Gene	NNP
cord-291950-9gtsqyfj	641	46	expression	expression	NN
cord-291950-9gtsqyfj	641	47	by	by	IN
cord-291950-9gtsqyfj	641	48	a	a	DT
cord-291950-9gtsqyfj	641	49	hypovirulence	hypovirulence	NN
cord-291950-9gtsqyfj	641	50	-	-	HYPH
cord-291950-9gtsqyfj	641	51	associated	associate	VBN
cord-291950-9gtsqyfj	641	52	virus	virus	NN
cord-291950-9gtsqyfj	641	53	of	of	IN
cord-291950-9gtsqyfj	641	54	the	the	DT
cord-291950-9gtsqyfj	641	55	chestnut	chestnut	NN
cord-291950-9gtsqyfj	641	56	blight	blight	NN
cord-291950-9gtsqyfj	641	57	fungus	fungus	NN
cord-291950-9gtsqyfj	641	58	involves	involve	VBZ
cord-291950-9gtsqyfj	641	59	two	two	CD
cord-291950-9gtsqyfj	641	60	papain	papain	NN
cord-291950-9gtsqyfj	641	61	-	-	HYPH
cord-291950-9gtsqyfj	641	62	like	like	JJ
cord-291950-9gtsqyfj	641	63	protease	protease	NN
cord-291950-9gtsqyfj	641	64	activities	activity	NNS
cord-291950-9gtsqyfj	641	65	.	.	.
cord-291950-9gtsqyfj	642	1	Essential	essential	JJ
cord-291950-9gtsqyfj	642	2	residues	residue	NNS
cord-291950-9gtsqyfj	642	3	and	and	CC
cord-291950-9gtsqyfj	642	4	cleavage	cleavage	NN
cord-291950-9gtsqyfj	642	5	site	site	NN
cord-291950-9gtsqyfj	642	6	requirements	requirement	NNS
cord-291950-9gtsqyfj	642	7	for	for	IN
cord-291950-9gtsqyfj	642	8	p48	p48	NNP
cord-291950-9gtsqyfj	642	9	autoproteolysis	autoproteolysis	NNP
cord-291950-9gtsqyfj	643	1	The	the	DT
cord-291950-9gtsqyfj	643	2	autocatalytic	autocatalytic	JJ
cord-291950-9gtsqyfj	643	3	protease	protease	NN
cord-291950-9gtsqyfj	643	4	p29	p29	NN
cord-291950-9gtsqyfj	643	5	encoded	encode	VBN
cord-291950-9gtsqyfj	643	6	by	by	IN
cord-291950-9gtsqyfj	643	7	a	a	DT
cord-291950-9gtsqyfj	643	8	hypovirulence	hypovirulence	NN
cord-291950-9gtsqyfj	643	9	-	-	HYPH
cord-291950-9gtsqyfj	643	10	associated	associate	VBN
cord-291950-9gtsqyfj	643	11	virus	virus	NN
cord-291950-9gtsqyfj	643	12	of	of	IN
cord-291950-9gtsqyfj	643	13	the	the	DT
cord-291950-9gtsqyfj	643	14	chestnut	chestnut	NN
cord-291950-9gtsqyfj	643	15	blight	blight	NN
cord-291950-9gtsqyfj	643	16	fungus	fungus	NN
cord-291950-9gtsqyfj	643	17	resembles	resemble	VBZ
cord-291950-9gtsqyfj	643	18	the	the	DT
cord-291950-9gtsqyfj	643	19	potyvirus	potyvirus	NN
cord-291950-9gtsqyfj	643	20	-	-	HYPH
cord-291950-9gtsqyfj	643	21	encoded	encode	VBN
cord-291950-9gtsqyfj	643	22	protease	protease	NN
cord-291950-9gtsqyfj	643	23	HC	HC	NNP
cord-291950-9gtsqyfj	643	24	-	-	HYPH
cord-291950-9gtsqyfj	643	25	Pro	Pro	NNP
cord-291950-9gtsqyfj	643	26	Identification	identification	NN
cord-291950-9gtsqyfj	643	27	of	of	IN
cord-291950-9gtsqyfj	643	28	the	the	DT
cord-291950-9gtsqyfj	643	29	cleavage	cleavage	NN
cord-291950-9gtsqyfj	643	30	site	site	NN
cord-291950-9gtsqyfj	643	31	recognized	recognize	VBN
cord-291950-9gtsqyfj	643	32	by	by	IN
cord-291950-9gtsqyfj	643	33	the	the	DT
cord-291950-9gtsqyfj	643	34	turnip	turnip	NN
cord-291950-9gtsqyfj	643	35	yellow	yellow	JJ
cord-291950-9gtsqyfj	643	36	mosaic	mosaic	NNP
cord-291950-9gtsqyfj	643	37	virus	virus	NN
cord-291950-9gtsqyfj	643	38	protease	protease	NN
cord-291950-9gtsqyfj	643	39	Identification	identification	NN
cord-291950-9gtsqyfj	643	40	of	of	IN
cord-291950-9gtsqyfj	643	41	the	the	DT
cord-291950-9gtsqyfj	643	42	essential	essential	JJ
cord-291950-9gtsqyfj	643	43	cysteine	cysteine	NN
cord-291950-9gtsqyfj	643	44	and	and	CC
cord-291950-9gtsqyfj	643	45	histidine	histidine	NN
cord-291950-9gtsqyfj	643	46	residues	residue	NNS
cord-291950-9gtsqyfj	643	47	of	of	IN
cord-291950-9gtsqyfj	643	48	the	the	DT
cord-291950-9gtsqyfj	643	49	turnip	turnip	NN
cord-291950-9gtsqyfj	643	50	yellow	yellow	JJ
cord-291950-9gtsqyfj	643	51	mosaic	mosaic	NNP
cord-291950-9gtsqyfj	643	52	virus	virus	NN
cord-291950-9gtsqyfj	643	53	protease	protease	NN
cord-291950-9gtsqyfj	643	54	Autocatalytic	autocatalytic	JJ
cord-291950-9gtsqyfj	643	55	processing	processing	NN
cord-291950-9gtsqyfj	643	56	of	of	IN
cord-291950-9gtsqyfj	643	57	the	the	DT
cord-291950-9gtsqyfj	643	58	223-kDa	223-kda	JJ
cord-291950-9gtsqyfj	643	59	protein	protein	NN
cord-291950-9gtsqyfj	643	60	of	of	IN
cord-291950-9gtsqyfj	643	61	Blueberry	Blueberry	NNP
cord-291950-9gtsqyfj	643	62	scorch	scorch	VBP
cord-291950-9gtsqyfj	643	63	carlavirus	carlavirus	NNP
cord-291950-9gtsqyfj	643	64	by	by	IN
cord-291950-9gtsqyfj	643	65	a	a	DT
cord-291950-9gtsqyfj	643	66	papain	papain	NN
cord-291950-9gtsqyfj	643	67	-	-	HYPH
cord-291950-9gtsqyfj	643	68	like	like	JJ
cord-291950-9gtsqyfj	643	69	proteinase	proteinase	NN
cord-291950-9gtsqyfj	643	70	Characterization	characterization	NN
cord-291950-9gtsqyfj	643	71	of	of	IN
cord-291950-9gtsqyfj	643	72	the	the	DT
cord-291950-9gtsqyfj	643	73	rubella	rubella	NN
cord-291950-9gtsqyfj	643	74	virus	virus	NN
cord-291950-9gtsqyfj	643	75	nonstructural	nonstructural	JJ
cord-291950-9gtsqyfj	643	76	protease	protease	NN
cord-291950-9gtsqyfj	643	77	domain	domain	NN
cord-291950-9gtsqyfj	643	78	and	and	CC
cord-291950-9gtsqyfj	643	79	its	-PRON-	PRP$
cord-291950-9gtsqyfj	643	80	cleavage	cleavage	NN
cord-291950-9gtsqyfj	643	81	site	site	NN
cord-291950-9gtsqyfj	643	82	Evidence	evidence	NN
cord-291950-9gtsqyfj	643	83	for	for	IN
cord-291950-9gtsqyfj	643	84	in	in	IN
cord-291950-9gtsqyfj	643	85	vitro	vitro	FW
cord-291950-9gtsqyfj	643	86	and	and	CC
cord-291950-9gtsqyfj	643	87	in	in	IN
cord-291950-9gtsqyfj	643	88	vivo	vivo	NN
cord-291950-9gtsqyfj	643	89	autocatalytic	autocatalytic	JJ
cord-291950-9gtsqyfj	643	90	processing	processing	NN
cord-291950-9gtsqyfj	643	91	of	of	IN
cord-291950-9gtsqyfj	643	92	the	the	DT
cord-291950-9gtsqyfj	643	93	primary	primary	JJ
cord-291950-9gtsqyfj	643	94	translation	translation	NN
cord-291950-9gtsqyfj	643	95	product	product	NN
cord-291950-9gtsqyfj	643	96	of	of	IN
cord-291950-9gtsqyfj	643	97	beet	beet	NN
cord-291950-9gtsqyfj	643	98	necrotic	necrotic	JJ
cord-291950-9gtsqyfj	643	99	yellow	yellow	JJ
cord-291950-9gtsqyfj	643	100	vein	vein	NN
cord-291950-9gtsqyfj	643	101	virus	virus	NN
cord-291950-9gtsqyfj	643	102	RNA	RNA	NNP
cord-291950-9gtsqyfj	643	103	1	1	CD
cord-291950-9gtsqyfj	643	104	by	by	IN
cord-291950-9gtsqyfj	643	105	a	a	DT
cord-291950-9gtsqyfj	643	106	papain	papain	NN
cord-291950-9gtsqyfj	643	107	-	-	HYPH
cord-291950-9gtsqyfj	643	108	like	like	JJ
cord-291950-9gtsqyfj	643	109	proteinase	proteinase	NN
cord-291950-9gtsqyfj	643	110	Beet	beet	NN
cord-291950-9gtsqyfj	643	111	yellows	yellow	NNS
cord-291950-9gtsqyfj	643	112	closterovirus	closterovirus	NNP
cord-291950-9gtsqyfj	643	113	:	:	:
cord-291950-9gtsqyfj	643	114	complete	complete	JJ
cord-291950-9gtsqyfj	643	115	genome	genome	NN
cord-291950-9gtsqyfj	643	116	structure	structure	NN
cord-291950-9gtsqyfj	643	117	and	and	CC
cord-291950-9gtsqyfj	643	118	identification	identification	NN
cord-291950-9gtsqyfj	643	119	of	of	IN
cord-291950-9gtsqyfj	643	120	a	a	DT
cord-291950-9gtsqyfj	643	121	leader	leader	NN
cord-291950-9gtsqyfj	643	122	papain	papain	NN
cord-291950-9gtsqyfj	643	123	-	-	HYPH
cord-291950-9gtsqyfj	643	124	like	like	JJ
cord-291950-9gtsqyfj	643	125	thiol	thiol	NN
cord-291950-9gtsqyfj	643	126	protease	protease	NN
cord-291950-9gtsqyfj	643	127	Nterminal	nterminal	JJ
cord-291950-9gtsqyfj	643	128	protease	protease	NN
cord-291950-9gtsqyfj	643	129	of	of	IN
cord-291950-9gtsqyfj	643	130	pestiviruses	pestiviruse	NNS
cord-291950-9gtsqyfj	643	131	:	:	:
cord-291950-9gtsqyfj	643	132	identification	identification	NN
cord-291950-9gtsqyfj	643	133	of	of	IN
cord-291950-9gtsqyfj	643	134	putative	putative	JJ
cord-291950-9gtsqyfj	643	135	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	643	136	residues	residue	NNS
cord-291950-9gtsqyfj	643	137	by	by	IN
cord-291950-9gtsqyfj	643	138	site	site	NN
cord-291950-9gtsqyfj	643	139	-	-	HYPH
cord-291950-9gtsqyfj	643	140	directed	direct	VBN
cord-291950-9gtsqyfj	643	141	mutagenesis	mutagenesis	NN
cord-291950-9gtsqyfj	643	142	Identification	identification	NN
cord-291950-9gtsqyfj	643	143	of	of	IN
cord-291950-9gtsqyfj	643	144	the	the	DT
cord-291950-9gtsqyfj	643	145	putative	putative	JJ
cord-291950-9gtsqyfj	643	146	staphylococcal	staphylococcal	JJ
cord-291950-9gtsqyfj	643	147	AgrB	AgrB	NNP
cord-291950-9gtsqyfj	643	148	catalytic	catalytic	JJ
cord-291950-9gtsqyfj	643	149	residues	residue	NNS
cord-291950-9gtsqyfj	643	150	involving	involve	VBG
cord-291950-9gtsqyfj	643	151	the	the	DT
cord-291950-9gtsqyfj	643	152	proteolytic	proteolytic	JJ
cord-291950-9gtsqyfj	643	153	cleavage	cleavage	NN
cord-291950-9gtsqyfj	643	154	of	of	IN
cord-291950-9gtsqyfj	643	155	AgrD	AgrD	NNP
cord-291950-9gtsqyfj	643	156	to	to	TO
cord-291950-9gtsqyfj	643	157	generate	generate	VB
cord-291950-9gtsqyfj	643	158	autoinducing	autoinducing	NN
cord-291950-9gtsqyfj	643	159	peptide	peptide	JJ
cord-291950-9gtsqyfj	643	160	A	a	DT
cord-291950-9gtsqyfj	643	161	role	role	NN
cord-291950-9gtsqyfj	643	162	for	for	IN
cord-291950-9gtsqyfj	643	163	type	type	NN
cord-291950-9gtsqyfj	644	1	I	-PRON-	PRP
cord-291950-9gtsqyfj	644	2	signal	signal	VBP
cord-291950-9gtsqyfj	644	3	peptidase	peptidase	NN
cord-291950-9gtsqyfj	644	4	in	in	IN
cord-291950-9gtsqyfj	644	5	Staphylococcus	Staphylococcus	NNP
cord-291950-9gtsqyfj	644	6	aureus	aureus	NN
cord-291950-9gtsqyfj	644	7	quorum	quorum	VBP
cord-291950-9gtsqyfj	644	8	sensing	sense	VBG
cord-291950-9gtsqyfj	644	9	Identification	identification	NN
cord-291950-9gtsqyfj	644	10	of	of	IN
cord-291950-9gtsqyfj	644	11	a	a	DT
cord-291950-9gtsqyfj	644	12	staphylococcal	staphylococcal	JJ
cord-291950-9gtsqyfj	644	13	AgrB	AgrB	NNP
cord-291950-9gtsqyfj	644	14	segment(s	segment(s	NNP
cord-291950-9gtsqyfj	644	15	)	)	-RRB-
cord-291950-9gtsqyfj	644	16	responsible	responsible	JJ
cord-291950-9gtsqyfj	644	17	for	for	IN
cord-291950-9gtsqyfj	644	18	group	group	NN
cord-291950-9gtsqyfj	644	19	-	-	HYPH
cord-291950-9gtsqyfj	644	20	specific	specific	JJ
cord-291950-9gtsqyfj	644	21	processing	processing	NN
cord-291950-9gtsqyfj	644	22	of	of	IN
cord-291950-9gtsqyfj	644	23	AgrD	AgrD	NNP
cord-291950-9gtsqyfj	644	24	by	by	IN
cord-291950-9gtsqyfj	644	25	gene	gene	NN
cord-291950-9gtsqyfj	644	26	swapping	swap	VBG
cord-291950-9gtsqyfj	644	27	Rawlings	Rawlings	NNP
cord-291950-9gtsqyfj	645	1	The	the	DT
cord-291950-9gtsqyfj	645	2	Wellcome	Wellcome	NNP
cord-291950-9gtsqyfj	645	3	Trust	Trust	NNP
cord-291950-9gtsqyfj	645	4	Sanger	Sanger	NNP
cord-291950-9gtsqyfj	645	5	Institute	Institute	NNP
cord-291950-9gtsqyfj	645	6	Email	email	NN
cord-291950-9gtsqyfj	645	7	:	:	:
cord-291950-9gtsqyfj	645	8	ab9@sanger.ac.uk	ab9@sanger.ac.uk	NNP
cord-291950-9gtsqyfj	646	1	Handbook	Handbook	NNP
cord-291950-9gtsqyfj	646	2	of	of	IN
cord-291950-9gtsqyfj	646	3	Proteolytic	Proteolytic	NNP
cord-291950-9gtsqyfj	646	4	Enzymes	Enzymes	NNPS
cord-291950-9gtsqyfj	646	5	,	,	,
cord-291950-9gtsqyfj	646	6	3rd	3rd	JJ
cord-291950-9gtsqyfj	646	7	Edn	Edn	NNP
cord-291950-9gtsqyfj	647	1	©	©	NN